0	5	TRAMP	tramp	NN
5	6	,	,	,
7	8	a	a	DT
9	14	novel	novel	JJ
15	34	apoptosis-mediating	apoptosis-mediating	JJ
35	43	receptor	receptor	NN
44	48	with	with	IN
49	57	sequence	sequence	NN
58	66	homology	homology	NN
67	69	to	to	TO
70	75	tumor	tumor	NN
76	84	necrosis	necrosis	NN
85	91	factor	factor	NN
92	100	receptor	receptor	NN
101	102	1	1	CD
103	106	and	and	CC
107	122	Fas(Apo-1/CD95)	fas(apo-1/cd95)	NN
122	123	.	.	.

125	126	A	a	DT
127	132	novel	novel	JJ
133	139	member	member	NN
140	142	of	of	IN
143	146	the	the	DT
147	152	tumor	tumor	NN
153	161	necrosis	necrosis	NN
162	168	factor	factor	NN
169	170	(	(	(
170	173	TNF	TNF	NNP
173	174	)	)	)
175	183	receptor	receptor	NN
184	190	family	family	NN
190	191	,	,	,
192	202	designated	designate	VBN
203	208	TRAMP	TRAMP	NNP
208	209	,	,	,
210	213	has	have	VBZ
214	218	been	be	VBN
219	229	identified	identify	VBN
229	230	.	.	.

231	234	The	the	DT
235	245	structural	structural	JJ
246	258	organization	organization	NN
259	261	of	of	IN
262	265	the	the	DT
266	269	393	393	CD
270	275	amino	amino	NN
276	280	acid	acid	NN
281	285	long	long	JJ
286	291	human	human	JJ
292	297	TRAMP	tramp	NN
298	300	is	be	VBZ
301	305	most	most	RBS
306	316	homologous	homologous	JJ
317	319	to	to	TO
320	323	TNF	TNF	NNP
324	332	receptor	receptor	NN
333	334	1	1	CD
334	335	.	.	.

336	341	TRAMP	tramp	NN
342	344	is	be	VBZ
345	355	abundantly	abundantly	RB
356	365	expressed	express	VBN
366	368	on	on	IN
369	379	thymocytes	thymocyte	NNS
380	383	and	and	CC
384	395	lymphocytes	lymphocyte	NNS
395	396	.	.	.

397	400	Its	its	PRP$
401	414	extracellular	extracellular	JJ
415	421	domain	domain	NN
422	424	is	be	VBZ
425	433	composed	compose	VBN
434	436	of	of	IN
437	441	four	four	CD
442	455	cysteine-rich	cysteine-rich	JJ
456	463	domains	domain	NNS
463	464	,	,	,
465	468	and	and	CC
469	472	the	the	DT
473	484	cytoplasmic	cytoplasmic	JJ
485	491	region	region	NN
492	500	contains	contain	VBZ
501	502	a	a	DT
503	508	death	death	NN
509	515	domain	domain	NN
516	521	known	know	VBN
522	524	to	to	TO
525	531	signal	signal	NN
532	541	apoptosis	apoptosis	NN
541	542	.	.	.

543	557	Overexpression	Overexpression	NNP
558	560	of	of	IN
561	566	TRAMP	TRAMP	NNP
567	572	leads	lead	VBZ
573	575	to	to	TO
576	579	two	two	CD
580	585	major	major	JJ
586	595	responses	response	NNS
595	596	,	,	,
597	606	NF-kappaB	NF-kappaB	NNP
607	617	activation	activation	NN
618	621	and	and	CC
622	631	apoptosis	apoptosis	NN
631	632	.	.	.

633	646	TRAMP-induced	tramp-induced	JJ
647	651	cell	cell	NN
652	657	death	death	NN
658	660	is	be	VBZ
661	670	inhibited	inhibit	VBN
671	673	by	by	IN
674	676	an	an	DT
677	686	inhibitor	inhibitor	NN
687	689	of	of	IN
690	698	ICE-like	ice-like	JJ
699	708	proteases	protease	NNS
708	709	,	,	,
710	713	but	but	CC
714	717	not	not	RB
718	720	by	by	IN
721	726	Bcl-2	bcl-2	NN
726	727	.	.	.

728	730	In	in	IN
731	739	addition	addition	NN
739	740	,	,	,
741	746	TRAMP	TRAMP	NNP
747	751	does	do	VBZ
752	755	not	not	RB
756	762	appear	appear	VB
763	765	to	to	TO
766	774	interact	interact	VB
775	779	with	with	IN
780	783	any	any	DT
784	786	of	of	IN
787	790	the	the	DT
791	796	known	known	JJ
797	815	apoptosis-inducing	apoptosis-inducing	JJ
816	823	ligands	ligand	NNS
824	826	of	of	IN
827	830	the	the	DT
831	834	TNF	TNF	NNP
835	841	family	family	NN
841	842	.	.	.