0 13 T-lymphocytes t-lymphocyte NNS 14 18 from from IN 19 30 individuals individual NNS 31 35 with with IN 36 44 filarial filarial JJ 45 57 inflammatory inflammatory JJ 58 65 disease disease NN 66 70 have have VBP 71 80 increased increase VBN 81 97 transendothelial transendothelial JJ 98 107 migration migration NN 108 110 in in FW 111 116 vitro vitro FW 116 117 . . . 119 122 The the DT 123 125 in in FW 126 131 vitro vitro FW 132 148 transendothelial transendothelial JJ 149 158 migration migration NN 159 161 of of IN 162 173 circulating circulate VBG 174 182 filarial filarial JJ 183 199 antigen-specific antigen-specific JJ 200 207 T-cells t-cell NNS 208 211 was be VBD 212 220 examined examine VBN 221 223 in in IN 224 234 Wuchereria Wuchereria NNP 235 244 banerofti banerofti NN 245 254 infection infection NN 254 255 . . . 256 267 Circulating circulate VBG 268 275 T-cells t-cell NNS 276 280 from from IN 281 292 individuals individual NNS 293 297 with with IN 298 313 filaria-induced filaria-induced JJ 314 323 lymphatic lymphatic JJ 324 333 pathology pathology NN 334 335 ( ( ( 335 337 LP LP NNP 337 338 ) ) ) 339 342 had have VBD 343 356 significantly significantly RB 357 364 greater great JJR 365 374 migration migration NN 375 382 through through IN 383 395 unstimulated unstimulated JJ 396 401 HUVEC HUVEC NNP 402 412 monolayers monolayer NNS 413 417 than than IN 418 421 did do VBD 422 429 T-cells t-cell NNS 430 434 from from IN 435 447 asymptomatic asymptomatic JJ 448 456 infected infected JJ 457 458 ( ( ( 458 460 MF mf JJ 460 461 ) ) ) 462 473 individuals individual NNS 474 475 ( ( ( 475 476 P p NN 477 478 = = SYM 479 483 0.04 0.04 CD 483 484 ) ) ) 484 485 . . . 486 488 In in IN 489 497 contrast contrast NN 498 500 to to TO 501 504 the the DT 505 507 MF MF NNP 508 519 individuals individual NNS 520 525 where where WRB 526 528 no no DT 529 535 effect effect NN 536 539 was be VBD 540 544 seen see VBN 544 545 , , , 546 562 transendothelial transendothelial JJ 563 572 migration migration NN 573 575 of of IN 576 581 48-hr 48-hr JJ 582 590 filarial filarial JJ 591 598 antigen antigen NN 599 609 stimulated stimulated JJ 610 617 T-cells T-cell NNP 618 622 from from IN 623 625 LP LP NNP 626 637 individuals individual NNS 638 641 was be VBD 642 655 significantly significantly RB 656 657 ( ( ( 657 658 P p NN 659 660 = = SYM 661 665 0.01 0.01 CD 665 666 ) ) ) 667 674 greater great JJR 675 679 than than IN 680 689 migration migration NN 690 692 of of IN 693 698 48-hr 48-hr JJ 699 715 media-stimulated media-stimulated JJ 716 723 T-cells t-cell NNS 723 724 . . . 725 727 In in IN 728 731 six six CD 732 734 of of IN 735 740 seven seven CD 741 749 patients patient NNS 750 758 examined examine VBN 758 759 , , , 760 770 inhibition inhibition NN 771 773 of of IN 774 777 the the DT 778 790 VLA-4/VCAM-1 vla-4/vcam-1 NN 791 798 pathway pathway NN 799 807 resulted result VBD 808 810 in in IN 811 818 greater great JJR 819 823 than than IN 824 826 50 50 CD 826 827 % % NN 828 838 inhibition inhibition NN 839 841 of of IN 842 858 transendothelial transendothelial JJ 859 868 migration migration NN 869 871 of of IN 872 879 T-cells T-cell NNP 879 880 . . .