0 11 Suppression suppression NN 12 14 by by IN 15 25 azelastine azelastine NN 26 39 hydrochloride hydrochloride NN 40 42 of of IN 43 51 NF-kappa NF-kappa NNP 52 53 B B NNP 54 64 activation activation NN 65 73 involved involve VBN 74 76 in in IN 77 87 generation generation NN 88 90 of of IN 91 100 cytokines cytokine NNS 101 104 and and CC 105 111 nitric nitric JJ 112 117 oxide oxide NN 117 118 . . . 120 123 The the DT 124 133 influence influence NN 134 136 of of IN 137 140 the the DT 141 153 anti-allergy anti-allergy JJ 154 159 agent agent NN 160 170 azelastine azelastine NN 171 184 hydrochloride hydrochloride NN 185 186 ( ( ( 186 193 Azeptin Azeptin NNP 193 194 ) ) ) 195 197 on on IN 198 206 NF-kappa NF-kappa NNP 207 208 B B NNP 209 219 activation activation NN 220 230 associated associate VBN 231 235 with with IN 236 239 the the DT 240 250 generation generation NN 251 253 of of IN 254 263 cytokines cytokine NNS 264 267 and and CC 268 274 nitric nitric JJ 275 280 oxide oxide NN 281 282 ( ( ( 282 284 NO no NN 284 285 ) ) ) 286 289 was be VBD 290 302 investigated investigate VBN 303 305 in in IN 306 313 various various JJ 314 319 kinds kind NNS 320 322 of of IN 323 328 human human JJ 329 332 and and CC 333 338 mouse mouse NN 339 344 cells cell NNS 344 345 . . . 346 353 Azeptin Azeptin NNP 354 370 dose-dependently dose-dependently RB 371 381 suppressed suppress VBD 382 386 both both CC 387 390 DNA dna NN 391 394 and and CC 395 402 protein protein NN 403 412 synthesis synthesis NN 413 415 in in IN 416 421 human human JJ 422 430 gingival gingival JJ 431 442 fibroblasts fibroblast NNS 443 444 ( ( ( 444 446 HF HF NNP 446 447 ) ) ) 448 451 and and CC 452 456 also also RB 457 467 suppressed suppress VBD 468 481 blastogenesis blastogenesis NN 482 484 of of IN 485 490 human human JJ 491 501 peripheral peripheral JJ 502 507 blood blood NN 508 519 lymphocytes lymphocyte NNS 520 521 ( ( ( 521 524 PBL PBL NNP 524 525 ) ) ) 525 526 . . . 527 537 Generation Generation NNP 538 540 of of IN 541 546 tumor tumor NN 547 555 necrosis necrosis NN 556 568 factor-alpha factor-alpha NN 568 569 , , , 570 581 interleukin interleukin NN 582 588 1-beta 1-beta NN 588 589 , , , 590 612 granulocyte-macrophage granulocyte-macrophage JJ 613 631 colony-stimulating colony-stimulating JJ 632 638 factor factor NN 639 642 and and CC 643 656 interleukin-6 interleukin-6 NN 657 661 from from IN 662 668 10(-5) 10(-5) CD 669 670 M M NNP 671 686 Azeptin-treated azeptin-treated JJ 687 690 PBL pbl NN 691 694 and and CC 695 700 human human JJ 701 710 monocytes monocyte NNS 711 712 ( ( ( 712 714 HM HM NNP 714 715 ) ) ) 716 719 was be VBD 720 729 decreased decrease VBN 730 732 to to TO 733 746 approximately approximately RB 747 750 1/3 1/3 CD 751 753 to to TO 754 757 2/3 2/3 CD 758 760 of of IN 761 764 the the DT 765 772 control control NN 773 779 levels level NNS 779 780 . . . 781 783 In in IN 784 792 parallel parallel NN 793 797 with with IN 798 801 the the DT 802 811 decreased decrease VBN 812 820 cytokine cytokine NN 821 831 generation generation NN 831 832 , , , 833 837 each each DT 838 846 cytokine cytokine NN 847 851 mRNA mrna NN 852 855 was be VBD 856 860 less less RBR 861 870 expressed express VBN 871 873 in in IN 874 877 the the DT 878 886 presence presence NN 887 889 of of IN 890 896 10(-5) 10(-5) CD 897 898 M M NNP 899 906 Azeptin Azeptin NNP 906 907 . . . 908 910 In in IN 911 919 addition addition NN 919 920 , , , 921 925 both both DT 926 935 inducible inducible JJ 936 942 nitric nitric JJ 943 948 oxide oxide NN 949 962 synthase-mRNA synthase-mrna NN 963 968 level level NN 969 972 and and CC 973 975 NO no NN 976 986 generation generation NN 987 989 in in IN 990 995 mouse mouse NN 996 1006 peritoneal peritoneal JJ 1007 1018 macrophages macrophage NNS 1019 1023 were be VBD 1024 1034 suppressed suppress VBN 1035 1037 by by IN 1038 1044 10(-5) 10(-5) CD 1045 1046 M M NNP 1047 1054 Azeptin Azeptin NNP 1054 1055 . . . 1056 1061 Being be VBG 1062 1072 compatible compatible JJ 1073 1077 with with IN 1078 1083 those those DT 1084 1091 results result NNS 1091 1092 , , , 1093 1100 Azeptin Azeptin NNP 1101 1102 ( ( ( 1102 1108 10(-5) 10(-5) CD 1109 1110 M M NNP 1110 1111 ) ) ) 1112 1122 suppressed suppress VBD 1123 1133 activation activation NN 1134 1136 of of IN 1137 1145 NF-kappa NF-kappa NNP 1146 1147 B B NNP 1148 1150 in in IN 1151 1154 PBL PBL NNP 1154 1155 , , , 1156 1158 HM HM NNP 1159 1162 and and CC 1163 1165 HF HF NNP 1165 1166 . . . 1167 1172 These these DT 1173 1180 results result NNS 1181 1187 appear appear VBP 1188 1190 to to TO 1191 1199 indicate indicate VB 1200 1204 that that IN 1205 1216 suppression suppression NN 1217 1219 of of IN 1220 1228 cytokine cytokine NN 1229 1232 and and CC 1233 1235 NO no NN 1236 1246 generation generation NN 1247 1249 by by IN 1250 1257 Azeptin Azeptin NNP 1258 1265 results result NNS 1266 1268 at at IN 1269 1274 least least JJS 1275 1284 partially partially RB 1285 1289 from from IN 1290 1293 the the DT 1294 1304 inhibition inhibition NN 1305 1307 of of IN 1308 1316 NF-kappa NF-kappa NNP 1317 1318 B B NNP 1319 1329 activation activation NN 1329 1330 . . .