0	3	The	the	DT
4	5	T	t	NN
6	10	cell	cell	NN
11	21	activation	activation	NN
22	28	factor	factor	NN
29	35	NF-ATc	NF-ATc	NNP
36	46	positively	positively	RB
47	56	regulates	regulate	VBZ
57	62	HIV-1	HIV-1	NNP
63	74	replication	replication	NN
75	78	and	and	CC
79	83	gene	gene	NN
84	94	expression	expression	NN
95	97	in	in	IN
98	99	T	t	NN
100	105	cells	cell	NNS
105	106	.	.	.

108	116	Clinical	clinical	JJ
117	130	deterioration	deterioration	NN
131	133	in	in	IN
134	139	human	human	JJ
140	156	immunodeficiency	immunodeficiency	NN
157	162	virus	virus	NN
163	167	type	type	NN
168	169	1	1	CD
170	171	(	(	(
171	176	HIV-1	HIV-1	NNP
176	177	)	)	)
178	187	infection	infection	NN
188	190	is	be	VBZ
191	201	associated	associate	VBN
202	206	with	with	IN
207	216	increased	increase	VBN
217	223	levels	level	NNS
224	226	of	of	IN
227	232	viral	viral	JJ
233	244	replication	replication	NN
245	248	and	and	CC
249	255	burden	burden	NN
256	258	in	in	IN
259	262	the	the	DT
263	273	peripheral	peripheral	JJ
274	279	blood	blood	NN
280	283	and	and	CC
284	292	lymphoid	lymphoid	JJ
293	299	organs	organ	NNS
299	300	.	.	.

301	302	T	t	NN
303	307	cell	cell	NN
308	318	activation	activation	NN
319	322	and	and	CC
323	330	ensuing	ensue	VBG
331	339	cellular	cellular	JJ
340	344	gene	gene	NN
345	355	activation	activation	NN
356	359	can	can	MD
360	362	be	be	VB
363	371	critical	critical	JJ
372	375	for	for	IN
376	381	HIV-1	HIV-1	NNP
382	393	replication	replication	NN
393	394	.	.	.

395	398	The	the	DT
399	409	hypothesis	hypothesis	NN
410	414	that	that	IN
415	418	the	the	DT
419	426	nuclear	nuclear	JJ
427	433	factor	factor	NN
434	436	of	of	IN
437	446	activated	activate	VBN
447	448	T	t	NN
449	454	cells	cell	NNS
455	456	(	(	(
456	461	NF-AT	NF-AT	NNP
461	462	)	)	)
463	466	may	may	MD
467	476	influence	influence	VB
477	482	HIV-1	HIV-1	NNP
483	494	replication	replication	NN
495	497	is	be	VBZ
498	507	therefore	therefore	RB
508	518	compelling	compelling	JJ
519	524	given	give	VBN
525	528	the	the	DT
529	534	tight	tight	JJ
535	546	correlation	correlation	NN
547	549	of	of	IN
550	555	HIV-1	HIV-1	NNP
556	571	transcriptional	transcriptional	JJ
572	581	induction	induction	NN
582	584	to	to	TO
585	586	T	t	NN
587	591	cell	cell	NN
592	602	activation	activation	NN
602	603	.	.	.

604	606	We	we	PRP
607	613	report	report	VBP
614	618	that	that	IN
619	626	certain	certain	JJ
627	637	NF-AT(Rel)	nf-at(rel)	NN
638	644	family	family	NN
645	652	members	member	NNS
653	665	productively	productively	RB
666	670	bind	bind	VBP
671	674	the	the	DT
675	681	kappaB	kappab	NN
682	692	regulatory	regulatory	JJ
693	701	elements	element	NNS
701	702	,	,	,
703	712	synergize	synergize	VBP
713	717	with	with	IN
718	727	NF-kappaB	NF-kappaB	NNP
728	731	and	and	CC
732	735	Tat	Tat	NNP
736	738	in	in	IN
739	754	transcriptional	transcriptional	JJ
755	765	activation	activation	NN
766	768	of	of	IN
769	774	HIV-1	HIV-1	NNP
774	775	,	,	,
776	779	and	and	CC
780	787	enhance	enhance	VBP
788	793	HIV-1	HIV-1	NNP
794	805	replication	replication	NN
806	808	in	in	IN
809	810	T	t	NN
811	816	cells	cell	NNS
816	817	.	.	.

818	823	These	these	DT
824	831	results	result	NNS
832	836	link	link	VBP
837	847	regulatory	regulatory	JJ
848	855	factors	factor	NNS
856	864	critical	critical	JJ
865	867	to	to	TO
868	869	T	t	NN
870	874	cell	cell	NN
875	885	commitment	commitment	NN
886	894	directly	directly	RB
895	897	to	to	TO
898	903	HIV-1	HIV-1	NNP
904	915	replication	replication	NN
915	916	.	.	.