0 18 Oxidant-regulation oxidant-regulation NN 19 21 of of IN 22 26 gene gene NN 27 37 expression expression NN 38 40 in in IN 41 44 the the DT 45 56 chronically chronically RB 57 65 inflamed inflamed JJ 66 75 intestine intestine NN 75 76 . . . 78 80 It it PRP 81 83 is be VBZ 84 92 becoming become VBG 93 105 increasingly increasingly RB 106 114 apparent apparent JJ 115 119 that that IN 120 123 the the DT 124 131 chronic chronic JJ 132 135 gut gut NN 136 148 inflammation inflammation NN 149 157 observed observe VBN 158 160 in in IN 161 164 the the DT 165 175 idiopathic idiopathic JJ 176 188 inflammatory inflammatory JJ 189 194 bowel bowel NN 195 203 diseases disease NNS 204 205 ( ( ( 205 209 e.g. e.g. FW 210 220 ulcerative ulcerative JJ 221 228 colitis colitis NN 228 229 , , , 230 235 Crohn Crohn NNP 235 237 ’s 's POS 238 245 disease disease NN 245 246 ) ) ) 247 249 is be VBZ 250 260 associated associate VBN 261 265 with with IN 266 274 enhanced enhance VBN 275 285 production production NN 286 288 of of IN 289 306 leukocyte-derived leukocyte-derived JJ 307 315 oxidants oxidant NNS 315 316 . . . 317 325 Oxidants oxidant NNS 326 330 such such JJ 331 333 as as IN 334 342 hydrogen hydrogen NN 343 351 peroxide peroxide NN 352 355 are be VBP 356 361 known know VBN 362 364 to to TO 365 373 activate activate VB 374 381 certain certain JJ 382 395 transcription transcription NN 396 403 factors factor NNS 404 408 such such JJ 409 411 as as IN 412 419 nuclear nuclear JJ 420 433 transcription transcription NN 434 440 factor factor NN 441 446 kappa kappa NN 447 451 beta beta NN 451 452 . . . 453 460 Nuclear nuclear JJ 461 474 transcription transcription NN 475 481 factor factor NN 482 484 kB kB NNP 485 486 ( ( ( 486 494 NF-kappa NF-kappa NNP 495 496 B B NNP 496 497 ) ) ) 498 500 is be VBZ 501 502 a a DT 503 513 ubiquitous ubiquitous JJ 514 527 transcription transcription NN 528 534 factor factor NN 535 538 and and CC 539 550 pleiotropic pleiotropic JJ 551 560 regulator regulator NN 561 563 of of IN 564 572 numerous numerous JJ 573 578 genes gene NNS 579 587 involved involve VBN 588 590 in in IN 591 594 the the DT 595 601 immune immune JJ 602 605 and and CC 606 618 inflammatory inflammatory JJ 619 628 responses response NNS 628 629 . . . 630 634 This this DT 635 648 transcription transcription NN 649 655 factor factor NN 656 658 is be VBZ 659 668 activated activate VBN 669 672 via via IN 673 676 the the DT 677 686 selective selective JJ 687 702 phosphorylation phosphorylation NN 702 703 , , , 704 716 ubiquination ubiquination NN 717 720 and and CC 721 732 degradation degradation NN 733 735 of of IN 736 739 its its PRP$ 740 749 inhibitor inhibitor NN 750 757 protein protein NN 758 762 I-kB i-kb NN 763 770 thereby thereby RB 771 779 allowing allow VBG 780 793 translocation translocation NN 794 796 of of IN 797 805 NF-kappa NF-kappa NNP 806 807 B B NNP 808 812 into into IN 813 816 the the DT 817 824 nucleus nucleus NN 825 830 where where WRB 831 833 it it PRP 834 845 upregulates upregulate VBZ 846 849 the the DT 850 863 transcription transcription NN 864 866 of of IN 867 868 a a DT 869 876 variety variety NN 877 879 of of IN 880 888 adhesion adhesion NN 889 898 molecules molecule NNS 899 900 ( ( ( 900 904 e.g. e.g. FW 905 911 ICAM-1 ICAM-1 NNP 911 912 , , , 913 919 VCAM-1 VCAM-1 NNP 919 920 ) ) ) 920 921 , , , 922 931 cytokines cytokine NNS 932 933 ( ( ( 933 936 TNF TNF NNP 936 937 , , , 938 942 IL-1 IL-1 NNP 942 943 , , , 944 948 IL-6 IL-6 NNP 948 949 ) ) ) 950 953 and and CC 954 961 enzymes enzyme NNS 962 963 ( ( ( 963 967 iNOS inos NN 967 968 ) ) ) 968 969 . . . 970 973 The the DT 974 985 proteolytic proteolytic JJ 986 997 degradation degradation NN 998 1000 of of IN 1001 1004 the the DT 1005 1025 post-translationally post-translationally RB 1026 1034 modified modify VBN 1035 1042 I-kappa I-kappa NNP 1043 1044 B B NNP 1045 1047 is be VBZ 1048 1053 known know VBN 1054 1056 to to TO 1057 1059 be be VB 1060 1068 mediated mediate VBN 1069 1071 by by IN 1072 1075 the the DT 1076 1079 26S 26s NN 1080 1090 proteasome proteasome NN 1091 1098 complex complex NN 1098 1099 . . . 1100 1105 Based base VBN 1106 1110 upon upon IN 1111 1115 work work NN 1116 1120 from from IN 1121 1124 our our PRP$ 1125 1135 laboratory laboratory NN 1135 1136 , , , 1137 1139 we we PRP 1140 1147 propose propose VBP 1148 1152 that that IN 1153 1163 inhibition inhibition NN 1164 1166 of of IN 1167 1175 NF-kappa NF-kappa NNP 1176 1177 B B NNP 1178 1188 activation activation NN 1189 1197 produces produce VBZ 1198 1209 significant significant JJ 1210 1214 anti anti JJ 1215 1227 inflammatory inflammatory JJ 1228 1236 activity activity NN 1237 1242 which which WDT 1243 1246 may may MD 1247 1249 be be VB 1250 1258 mediated mediate VBN 1259 1261 by by IN 1262 1265 the the DT 1266 1276 inhibition inhibition NN 1277 1279 of of IN 1280 1293 transcription transcription NN 1294 1296 of of IN 1297 1304 certain certain JJ 1305 1321 pro-inflammatory pro-inflammatory JJ 1322 1331 mediators mediator NNS 1332 1335 and and CC 1336 1344 adhesion adhesion NN 1345 1354 molecules molecule NNS 1354 1355 . . .