0 10 Expression expression NN 11 13 of of IN 14 23 LAZ3/BCL6 laz3/bcl6 NN 24 26 in in IN 27 37 follicular follicular JJ 38 44 center center NN 45 46 ( ( ( 46 48 FC FC NNP 48 49 ) ) ) 50 51 B B NNP 52 57 cells cell NNS 58 60 of of IN 61 69 reactive reactive JJ 70 75 lymph lymph NN 76 81 nodes node NNS 82 85 and and CC 86 96 FC-derived fc-derived JJ 97 108 non-Hodgkin non-hodgkin JJ 109 118 lymphomas lymphoma NNS 118 119 . . . 121 132 Chromosomal chromosomal JJ 133 146 translocation translocation NN 147 156 resulting result VBG 157 159 in in IN 160 168 abnormal abnormal JJ 169 179 expression expression NN 180 182 of of IN 183 186 the the DT 187 196 LAZ3/BCL6 LAZ3/BCL6 NNP 197 201 gene gene NN 202 204 in in IN 205 206 B B NNP 207 212 cells cell NNS 213 216 has have VBZ 217 221 been be VBN 222 232 implicated implicate VBN 233 235 in in IN 236 239 the the DT 240 253 tumorigenesis tumorigenesis NN 254 256 of of IN 257 268 non-Hodgkin non-hodgkin JJ 269 277 lymphoma lymphoma NN 278 279 ( ( ( 279 282 NHL NHL NNP 282 283 ) ) ) 283 284 . . . 285 294 Therefore therefore RB 295 297 we we PRP 298 305 studied study VBD 306 309 the the DT 310 320 expression expression NN 321 328 pattern pattern NN 329 331 of of IN 332 341 LAZ3/BCL6 LAZ3/BCL6 NNP 342 344 by by IN 345 347 in in FW 348 352 situ situ FW 353 366 hybridization hybridization NN 367 371 with with IN 372 381 synthetic synthetic JJ 382 397 oligonucleotide oligonucleotide NN 398 404 probes probe NNS 405 407 in in IN 408 414 frozen frozen JJ 415 421 tissue tissue NN 422 430 sections section NNS 431 435 from from IN 436 440 five five CD 441 449 reactive reactive JJ 450 455 lymph lymph NN 456 461 nodes node NNS 462 465 and and CC 466 468 38 38 CD 469 470 B B NNP 471 475 cell cell NN 476 479 and and CC 480 485 non-B non-b JJ 486 489 NHL nhl NN 489 490 . . . 491 493 In in IN 494 502 addition addition NN 502 503 , , , 504 506 we we PRP 507 519 investigated investigate VBD 520 523 the the DT 524 534 expression expression NN 535 537 of of IN 538 547 LAZ3/BCL6 LAZ3/BCL6 NNP 548 550 by by IN 551 559 Northern Northern NNP 560 564 blot blot NN 565 573 analysis analysis NN 574 576 on on IN 577 585 multiple multiple JJ 586 591 human human JJ 592 599 tissues tissue NNS 599 600 . . . 601 604 The the DT 605 614 LAZ3/BCL6 LAZ3/BCL6 NNP 615 625 transcript transcript NN 626 629 was be VBD 630 635 found find VBN 636 638 in in IN 639 640 a a DT 641 648 variety variety NN 649 651 of of IN 652 659 tissues tissue NNS 659 660 , , , 661 670 including include VBG 671 679 skeletal skeletal JJ 680 686 muscle muscle NN 686 687 , , , 688 698 peripheral peripheral JJ 699 704 blood blood NN 705 715 leukocytes leukocyte NNS 715 716 , , , 717 720 and and CC 721 727 weakly weakly RB 728 730 in in IN 731 737 normal normal JJ 738 743 lymph lymph NN 744 749 nodes node NNS 749 750 . . . 751 753 In in IN 754 757 the the DT 758 763 tumor tumor NN 764 771 samples sample NNS 771 772 , , , 773 783 expression expression NN 784 786 of of IN 787 796 LAZ3/BCL6 LAZ3/BCL6 NNP 797 800 was be VBD 801 809 observed observe VBN 810 812 in in IN 813 815 68 68 CD 815 816 % % NN 817 819 of of IN 820 823 all all DT 824 825 B B NNP 826 830 cell cell NN 831 834 NHL nhl NN 835 838 and and CC 839 843 none none NN 844 846 of of IN 847 850 the the DT 851 856 non-B non-b JJ 857 866 lymphomas lymphoma NNS 866 867 . . . 868 871 All all DT 872 877 cases case NNS 878 880 of of IN 881 891 follicular follicular JJ 891 892 , , , 893 898 mixed mixed JJ 899 904 small small JJ 905 908 and and CC 909 914 large large JJ 915 919 cell cell NN 920 929 lymphomas lymphoma NNS 930 936 showed show VBD 937 946 LAZ3/BCL6 laz3/bcl6 NN 947 957 expression expression NN 958 966 confined confine VBN 967 969 to to TO 970 973 the the DT 974 984 neoplastic neoplastic JJ 985 994 follicles follicle NNS 994 995 . . . 996 997 A a DT 998 1008 follicular follicular JJ 1009 1019 expression expression NN 1020 1027 pattern pattern NN 1028 1031 was be VBD 1032 1036 also also RB 1037 1042 found find VBN 1043 1045 in in IN 1046 1049 all all DT 1050 1063 non-malignant non-malignant JJ 1064 1072 reactive reactive JJ 1073 1078 lymph lymph NN 1079 1084 nodes node NNS 1084 1085 . . . 1086 1091 Hence hence RB 1091 1092 , , , 1093 1096 the the DT 1097 1107 expression expression NN 1108 1110 of of IN 1111 1120 LAZ3/BCL6 LAZ3/BCL6 NNP 1121 1125 does do VBZ 1126 1129 not not RB 1130 1139 correlate correlate VB 1140 1142 to to TO 1143 1153 malignancy malignancy NN 1153 1154 , , , 1155 1158 but but CC 1159 1167 reflects reflect VBZ 1168 1171 the the DT 1172 1178 origin origin NN 1179 1181 of of IN 1182 1183 B B NNP 1184 1189 cells cell NNS 1190 1194 from from IN 1195 1198 the the DT 1199 1207 germinal germinal JJ 1208 1215 centers center NNS 1215 1216 . . .