0 8 Lineage- lineage- NN 9 12 and and CC 13 27 stage-specific stage-specific JJ 28 38 expression expression NN 39 41 of of IN 42 46 runt runt NN 47 50 box box NN 51 63 polypeptides polypeptide NNS 64 66 in in IN 67 76 primitive primitive JJ 77 80 and and CC 81 91 definitive definitive JJ 92 105 hematopoiesis hematopoiesis NN 105 106 . . . 108 122 Translocations translocation NNS 123 132 involving involve VBG 133 136 the the DT 137 142 human human JJ 143 148 CBFA2 cbfa2 NN 149 154 locus locus NN 155 159 have have VBP 160 164 been be VBN 165 175 associated associate VBN 176 180 with with IN 181 189 leukemia leukemia NN 189 190 . . . 191 195 This this DT 196 200 gene gene NN 200 201 , , , 202 212 originally originally RB 213 218 named name VBN 219 223 AML1 aml1 NN 223 224 , , , 225 227 is be VBZ 228 229 a a DT 230 235 human human JJ 236 245 homologue homologue NN 246 248 of of IN 249 252 the the DT 253 263 Drosophila Drosophila NNP 264 268 gene gene NN 269 273 runt runt NN 274 278 that that WDT 279 287 controls control VBZ 288 293 early early JJ 294 300 events event NNS 301 303 in in IN 304 307 fly fly NN 308 321 embryogenesis embryogenesis NN 321 322 . . . 323 325 To to TO 326 333 clarify clarify VB 334 337 the the DT 338 342 role role NN 343 345 of of IN 346 355 mammalian mammalian JJ 356 360 runt runt NN 361 369 products product NNS 370 372 in in IN 373 379 normal normal JJ 380 383 and and CC 384 392 leukemic leukemic JJ 393 406 hematopoiesis hematopoiesis NN 406 407 , , , 408 410 we we PRP 411 415 have have VBP 416 423 studied study VBN 424 429 their their PRP$ 430 437 pattern pattern NN 438 440 of of IN 441 451 expression expression NN 452 454 in in IN 455 460 mouse mouse NN 461 474 hematopoietic hematopoietic JJ 475 482 tissues tissue NNS 483 485 in in IN 486 489 the the DT 490 495 adult adult NN 496 499 and and CC 500 506 during during IN 507 515 ontogeny ontogeny NN 516 521 using use VBG 522 524 an an DT 525 534 anti-runt anti-runt JJ 535 538 box box NN 539 548 antiserum antiserum NN 548 549 . . . 550 552 In in IN 553 556 the the DT 557 562 adult adult JJ 563 567 bone bone NN 568 574 marrow marrow NN 574 575 , , , 576 578 we we PRP 579 584 found find VBD 585 595 expression expression NN 596 598 of of IN 599 603 runt runt NN 604 616 polypeptides polypeptide NNS 617 619 in in IN 620 635 differentiating differentiate VBG 636 643 myeloid myeloid JJ 644 649 cells cell NNS 650 653 and and CC 654 656 in in IN 657 658 B B NNP 659 670 lymphocytes lymphocyte NNS 670 671 . . . 672 678 Within within IN 679 682 the the DT 683 692 erythroid erythroid JJ 693 700 lineage lineage NN 700 701 , , , 702 706 runt runt NN 707 717 expression expression NN 718 720 is be VBZ 721 729 biphasic biphasic JJ 729 730 , , , 731 738 clearly clearly RB 739 746 present present JJ 747 749 in in IN 750 753 the the DT 754 767 erythroblasts erythroblast NNS 768 770 of of IN 771 776 early early JJ 777 782 blood blood NN 783 790 islands island NNS 791 794 and and CC 795 797 of of IN 798 801 the the DT 802 807 fetal fetal JJ 808 813 liver liver NN 813 814 , , , 815 818 but but CC 819 825 absent absent JJ 826 828 in in IN 829 832 the the DT 833 838 adult adult NN 838 839 . . . 840 851 Biochemical biochemical JJ 852 860 analysis analysis NN 861 863 by by IN 864 871 Western western JJ 872 880 blotting blotting NN 881 883 of of IN 884 889 fetal fetal JJ 890 893 and and CC 894 899 adult adult JJ 900 913 hematopoietic hematopoietic JJ 914 925 populations population NNS 926 931 shows show VBZ 932 939 several several JJ 940 944 runt runt NN 945 953 isoforms isoform NNS 953 954 . . . 955 957 At at IN 958 963 least least JJS 964 967 one one CD 968 970 of of IN 971 975 them them PRP 976 983 appears appear VBZ 984 986 to to TO 987 989 be be VB 990 997 myeloid myeloid JJ 998 1006 specific specific JJ 1006 1007 . . .