0	10	Regulation	regulation	NN
11	13	of	of	IN
14	19	human	human	JJ
20	27	epsilon	epsilon	NN
28	36	germline	germline	NN
37	50	transcription	transcription	NN
50	51	:	:	:
52	56	role	role	NN
57	59	of	of	IN
60	75	B-cell-specific	b-cell-specific	JJ
76	85	activator	activator	NN
86	93	protein	protein	NN
93	94	.	.	.

96	104	Germline	Germline	NNP
105	116	transcripts	transcript	NNS
117	125	initiate	initiate	VBP
126	130	from	from	IN
131	140	promoters	promoter	NNS
141	149	upstream	upstream	RB
150	152	of	of	IN
153	156	the	the	DT
157	171	immunoglobulin	immunoglobulin	NN
172	178	switch	switch	NN
179	185	region	region	NN
185	186	,	,	,
187	190	and	and	CC
191	194	are	be	VBP
195	204	necessary	necessary	JJ
205	207	to	to	TO
208	214	target	target	VB
215	218	the	the	DT
219	230	appropriate	appropriate	JJ
231	237	switch	switch	NN
238	244	region	region	NN
245	248	for	for	IN
249	262	recombination	recombination	NN
263	266	and	and	CC
267	276	switching	switching	NN
276	277	.	.	.

278	287	Different	different	JJ
288	297	cytokines	cytokine	NNS
298	306	activate	activate	VBP
307	320	transcription	transcription	NN
321	323	at	at	IN
324	327	the	the	DT
328	339	appropriate	appropriate	JJ
340	348	germline	germline	NN
349	357	promoter	promoter	NN
357	358	.	.	.

359	366	Because	because	IN
367	374	binding	bind	VBG
375	380	sites	site	NNS
381	384	for	for	IN
385	400	B-cell-specific	b-cell-specific	JJ
401	410	activator	activator	NN
411	418	protein	protein	NN
419	420	(	(	(
420	424	BSAP	BSAP	NNP
424	425	)	)	)
426	429	are	be	VBP
430	437	located	located	JJ
438	446	upstream	upstream	RB
447	449	of	of	IN
450	457	several	several	JJ
458	464	switch	switch	NN
465	472	regions	region	NNS
473	475	in	in	IN
476	479	the	the	DT
480	494	immunoglobulin	immunoglobulin	NN
495	500	heavy	heavy	JJ
501	506	chain	chain	NN
507	511	gene	gene	NN
512	519	cluster	cluster	NN
519	520	,	,	,
521	525	BSAP	BSAP	NNP
526	531	might	might	MD
532	536	play	play	VB
537	538	a	a	DT
539	543	role	role	NN
544	546	in	in	IN
547	550	the	the	DT
551	561	regulation	regulation	NN
562	564	of	of	IN
565	573	germline	germline	NN
574	587	transcription	transcription	NN
588	591	and	and	CC
592	599	isotype	isotype	NN
600	609	switching	switching	NN
609	610	.	.	.

611	613	We	we	PRP
614	626	investigated	investigate	VBD
627	634	whether	whether	IN
635	639	BSAP	BSAP	NNP
640	645	plays	play	VBZ
646	647	a	a	DT
648	652	role	role	NN
653	655	in	in	IN
656	659	the	the	DT
660	675	transcriptional	transcriptional	JJ
676	686	regulation	regulation	NN
687	689	of	of	IN
690	693	the	the	DT
694	701	epsilon	epsilon	NN
702	710	germline	germline	NN
711	719	promoter	promoter	NN
720	722	in	in	IN
723	728	human	human	JJ
729	730	B	B	NNP
731	736	cells	cell	NNS
736	737	.	.	.

738	741	Our	our	PRP$
742	749	results	result	NNS
750	756	showed	show	VBD
757	761	that	that	IN
762	766	BSAP	BSAP	NNP
767	772	plays	play	VBZ
773	774	a	a	DT
775	779	role	role	NN
780	782	in	in	IN
783	787	both	both	CC
788	802	IL-4-dependent	il-4-dependent	JJ
803	812	induction	induction	NN
813	816	and	and	CC
817	830	CD40-mediated	cd40-mediated	JJ
831	843	upregulation	upregulation	NN
844	846	of	of	IN
847	852	human	human	JJ
853	860	epsilon	epsilon	NN
861	869	germline	germline	NN
870	883	transcription	transcription	NN
883	884	.	.	.

885	889	BSAP	BSAP	NNP
890	892	is	be	VBZ
893	899	unique	unique	JJ
900	905	among	among	IN
906	909	the	the	DT
910	923	transcription	transcription	NN
924	931	factors	factor	NNS
932	936	that	that	WDT
937	945	regulate	regulate	VBP
946	953	epsilon	epsilon	NN
954	962	germline	germline	NN
963	973	expression	expression	NN
973	974	,	,	,
975	982	because	because	IN
983	985	it	it	PRP
986	988	is	be	VBZ
989	990	B	B	NNP
991	995	cell	cell	NN
996	1004	specific	specific	JJ
1004	1005	,	,	,
1006	1009	and	and	CC
1010	1012	is	be	VBZ
1013	1015	at	at	IN
1016	1019	the	the	DT
1020	1027	merging	merging	JJ
1028	1033	point	point	NN
1034	1036	of	of	IN
1037	1040	two	two	CD
1041	1051	signalling	signalling	NN
1052	1060	pathways	pathway	NNS
1061	1065	that	that	WDT
1066	1069	are	be	VBP
1070	1078	critical	critical	JJ
1079	1082	for	for	IN
1083	1086	IgE	IgE	NNP
1087	1096	switching	switching	NN
1096	1097	.	.	.