0	3	Tap	tap	NN
3	4	:	:	:
5	6	a	a	DT
7	12	novel	novel	JJ
13	21	cellular	cellular	JJ
22	29	protein	protein	NN
30	34	that	that	WDT
35	44	interacts	interact	VBZ
45	49	with	with	IN
50	53	tip	tip	NN
54	56	of	of	IN
57	68	herpesvirus	herpesvirus	NN
69	76	saimiri	saimiri	NN
77	80	and	and	CC
81	88	induces	induce	VBZ
89	99	lymphocyte	lymphocyte	NN
100	111	aggregation	aggregation	NN
111	112	.	.	.

114	117	Tip	Tip	NNP
118	120	of	of	IN
121	132	herpesvirus	herpesvirus	NN
133	140	saimiri	saimiri	NN
141	151	associates	associate	VBZ
152	156	with	with	IN
157	160	Lck	Lck	NNP
161	164	and	and	CC
165	179	down-regulates	down-regulate	VBZ
180	192	Lck-mediated	lck-mediated	JJ
193	203	activation	activation	NN
203	204	.	.	.

205	207	We	we	PRP
208	218	identified	identify	VBD
219	220	a	a	DT
221	226	novel	novel	JJ
227	235	cellular	cellular	JJ
236	250	Tip-associated	tip-associated	JJ
251	258	protein	protein	NN
259	260	(	(	(
260	263	Tap	tap	NN
263	264	)	)	)
265	267	by	by	IN
268	269	a	a	DT
270	275	yeast	yeast	NN
276	286	two-hybrid	two-hybrid	JJ
287	293	screen	screen	NN
293	294	.	.	.

295	298	Tap	tap	NN
299	309	associated	associate	VBN
310	314	with	with	IN
315	318	Tip	Tip	NNP
319	328	following	follow	VBG
329	338	transient	transient	JJ
339	349	expression	expression	NN
350	352	in	in	IN
353	358	COS-1	cos-1	NN
359	364	cells	cell	NNS
365	368	and	and	CC
369	375	stable	stable	JJ
376	386	expression	expression	NN
387	389	in	in	IN
390	395	human	human	JJ
396	404	Jurkat-T	jurkat-t	NN
405	410	cells	cell	NNS
410	411	.	.	.

412	422	Expression	expression	NN
423	425	of	of	IN
426	429	Tip	Tip	NNP
430	433	and	and	CC
434	437	Tap	tap	NN
438	440	in	in	IN
441	449	Jurkat-T	Jurkat-T	NNP
450	455	cells	cell	NNS
456	463	induced	induce	VBD
464	472	dramatic	dramatic	JJ
473	477	cell	cell	NN
478	489	aggregation	aggregation	NN
489	490	.	.	.

491	502	Aggregation	Aggregation	NNP
503	506	was	be	VBD
507	513	likely	likely	RB
514	520	caused	cause	VBN
521	523	by	by	IN
524	527	the	the	DT
528	540	up-regulated	up-regulate	VBN
541	548	surface	surface	NN
549	559	expression	expression	NN
560	562	of	of	IN
563	571	adhesion	adhesion	NN
572	581	molecules	molecule	NNS
582	591	including	include	VBG
592	600	integrin	integrin	NN
601	606	alpha	alpha	NN
606	607	,	,	,
608	618	L-selectin	L-selectin	NNP
618	619	,	,	,
620	626	ICAM-3	ICAM-3	NNP
626	627	,	,	,
628	631	and	and	CC
632	637	H-CAM	H-CAM	NNP
637	638	.	.	.

639	650	Furthermore	furthermore	RB
650	651	,	,	,
652	661	NF-kappaB	NF-kappaB	NNP
662	677	transcriptional	transcriptional	JJ
678	684	factor	factor	NN
685	687	of	of	IN
688	698	aggregated	aggregated	JJ
699	704	cells	cell	NNS
705	708	had	have	VBD
709	722	approximately	approximately	RB
723	730	40-fold	40-fold	RB
731	737	higher	high	JJR
738	746	activity	activity	NN
747	751	than	than	IN
752	756	that	that	DT
757	759	of	of	IN
760	768	parental	parental	JJ
769	774	cells	cell	NNS
774	775	.	.	.

776	780	Thus	thus	RB
780	781	,	,	,
782	785	Tap	tap	NN
786	788	is	be	VBZ
789	795	likely	likely	JJ
796	798	to	to	TO
799	801	be	be	VB
802	804	an	an	DT
805	814	important	important	JJ
815	823	cellular	cellular	JJ
824	832	mediator	mediator	NN
833	835	of	of	IN
836	839	Tip	Tip	NNP
840	848	function	function	NN
849	851	in	in	IN
852	853	T	t	NN
854	858	cell	cell	NN
859	873	transformation	transformation	NN
874	876	by	by	IN
877	888	herpesvirus	herpesvirus	NN
889	896	saimiri	saimiri	NN
896	897	.	.	.