0	8	Biphasic	biphasic	JJ
9	16	control	control	NN
17	19	of	of	IN
20	28	NF-kappa	NF-kappa	NNP
29	30	B	B	NNP
31	41	activation	activation	NN
42	49	induced	induce	VBN
50	52	by	by	IN
53	56	the	the	DT
57	67	triggering	triggering	NN
68	70	of	of	IN
71	77	HLA-DR	HLA-DR	NNP
78	86	antigens	antigen	NNS
87	96	expressed	express	VBN
97	99	on	on	IN
100	101	B	B	NNP
102	107	cells	cell	NNS
107	108	.	.	.

110	113	The	the	DT
114	124	regulation	regulation	NN
125	127	of	of	IN
128	136	NF-kappa	NF-kappa	NNP
137	138	B	B	NNP
139	149	activation	activation	NN
150	159	following	follow	VBG
160	163	the	the	DT
164	174	triggering	triggering	NN
175	177	of	of	IN
178	184	HLA-DR	HLA-DR	NNP
185	193	antigens	antigen	NNS
194	196	by	by	IN
197	200	mAb	mab	NN
201	205	L243	l243	NN
206	209	has	have	VBZ
210	214	been	be	VBN
215	222	studied	study	VBN
223	225	at	at	IN
226	233	various	various	JJ
234	239	times	time	NNS
240	242	in	in	IN
243	247	Raji	Raji	NNP
248	253	cells	cell	NNS
253	254	.	.	.

255	270	Electrophoretic	electrophoretic	JJ
271	279	mobility	mobility	NN
280	285	shift	shift	NN
286	292	assays	assay	NNS
293	305	demonstrated	demonstrate	VBD
306	307	a	a	DT
308	314	strong	strong	JJ
315	323	increase	increase	NN
324	326	of	of	IN
327	335	NF-kappa	NF-kappa	NNP
336	337	B	B	NNP
338	341	DNA	DNA	NNP
342	349	binding	binding	NN
350	355	after	after	IN
356	366	triggering	triggering	NN
367	369	of	of	IN
370	376	HLA-DR	HLA-DR	NNP
377	385	antigens	antigen	NNS
385	386	.	.	.

387	392	Using	use	VBG
393	411	TNF-alpha-activity	tnf-alpha-activity	NN
412	424	neutralizing	neutralize	VBG
425	435	antibodies	antibody	NNS
435	436	,	,	,
437	440	the	the	DT
441	448	authors	author	NNS
449	461	demonstrated	demonstrate	VBD
462	466	that	that	IN
467	470	the	the	DT
471	483	upregulation	upregulation	NN
484	486	of	of	IN
487	495	NF-kappa	NF-kappa	NNP
496	497	B	B	NNP
498	501	was	be	VBD
502	507	found	find	VBN
508	510	to	to	TO
511	517	depend	depend	VB
517	518	,	,	,
519	521	at	at	IN
522	527	later	late	JJR
528	532	time	time	NN
533	538	point	point	NN
538	539	,	,	,
540	542	on	on	IN
543	545	an	an	DT
546	555	autocrine	autocrine	JJ
556	562	effect	effect	NN
563	565	of	of	IN
566	575	TNF-alpha	TNF-alpha	NNP
576	584	secreted	secrete	VBN
585	594	following	follow	VBG
595	605	triggering	triggering	NN
606	608	of	of	IN
609	615	HLA-DR	HLA-DR	NNP
616	624	antigens	antigen	NNS
624	625	.	.	.

626	628	In	in	IN
629	637	contrast	contrast	NN
637	638	,	,	,
639	641	it	it	PRP
642	645	was	be	VBD
646	651	found	find	VBN
652	654	to	to	TO
655	657	be	be	VB
658	667	TNF-alpha	TNF-alpha	NNP
668	679	independent	independent	JJ
680	682	in	in	IN
683	686	the	the	DT
687	692	early	early	JJ
693	697	time	time	NN
698	703	point	point	NN
703	704	.	.	.

705	713	Moreover	moreover	RB
713	714	,	,	,
715	718	the	the	DT
719	731	upregulation	upregulation	NN
732	734	of	of	IN
735	743	NF-kappa	NF-kappa	NNP
744	745	B	B	NNP
746	753	binding	binding	NN
754	762	activity	activity	NN
763	765	is	be	VBZ
766	775	regulated	regulate	VBN
776	778	by	by	IN
779	782	the	the	DT
783	793	triggering	triggering	NN
794	796	of	of	IN
797	805	selected	select	VBN
806	814	epitopes	epitope	NNS
815	817	of	of	IN
818	824	HLA-DR	HLA-DR	NNP
825	833	antigens	antigen	NNS
833	834	.	.	.

835	837	In	in	IN
838	842	fact	fact	NN
842	843	,	,	,
844	847	mAb	mab	NN
848	852	L243	l243	NN
853	856	but	but	CC
857	860	not	not	RB
861	864	the	the	DT
865	879	staphylococcal	staphylococcal	JJ
880	893	superantigens	superantigen	NNS
893	894	,	,	,
895	909	staphylococcal	staphylococcal	JJ
910	918	exotoxin	exotoxin	NN
919	924	toxic	toxic	JJ
925	930	shock	shock	NN
931	939	syndrome	syndrome	NN
940	947	toxin-I	toxin-i	NN
948	950	or	or	CC
951	965	staphylococcal	staphylococcal	JJ
966	977	enterotoxin	enterotoxin	NN
978	979	B	B	NNP
979	980	,	,	,
981	989	regulate	regulate	VBP
990	993	the	the	DT
994	1002	NF-kappa	NF-kappa	NNP
1003	1004	B	B	NNP
1005	1012	binding	binding	NN
1013	1021	activity	activity	NN
1021	1022	.	.	.