0 6 Rescue rescue NN 7 9 by by IN 10 19 cytokines cytokine NNS 20 22 of of IN 23 32 apoptotic apoptotic JJ 33 37 cell cell NN 38 43 death death NN 44 51 induced induce VBN 52 54 by by IN 55 59 IL-2 il-2 NN 60 71 deprivation deprivation NN 72 74 of of IN 75 80 human human JJ 81 97 antigen-specific antigen-specific JJ 98 99 T t NN 100 104 cell cell NN 105 111 clones clone NNS 111 112 . . . 114 117 The the DT 118 125 control control NN 126 128 of of IN 129 133 cell cell NN 134 142 survival survival NN 143 146 and and CC 147 151 cell cell NN 152 157 death death NN 158 160 is be VBZ 161 163 of of IN 164 171 central central JJ 172 182 importance importance NN 183 185 in in IN 186 193 tissues tissue NNS 194 198 with with IN 199 203 high high JJ 204 208 cell cell NN 209 217 turnover turnover NN 218 222 such such JJ 223 225 as as IN 226 229 the the DT 230 238 lymphoid lymphoid JJ 239 245 system system NN 245 246 . . . 247 249 We we PRP 250 254 have have VBP 255 263 examined examine VBN 264 267 the the DT 268 274 effect effect NN 275 277 of of IN 278 287 cytokines cytokine NNS 288 290 on on IN 291 295 IL-2 il-2 NN 296 315 deprivation-induced deprivation-induced JJ 316 325 apoptosis apoptosis NN 326 328 of of IN 329 334 human human JJ 335 351 antigen-specific antigen-specific JJ 352 353 T t NN 354 360 helper helper NN 361 367 clones clone NNS 368 372 with with IN 373 382 different different JJ 383 391 cytokine cytokine NN 392 402 production production NN 403 411 profiles profile NNS 411 412 . . . 413 415 We we PRP 416 421 found find VBD 422 426 that that IN 427 431 IL-2 il-2 NN 431 432 , , , 433 449 interferon-alpha interferon-alpha NN 450 451 ( ( ( 451 460 IFN-alpha IFN-alpha NNP 460 461 ) ) ) 461 462 , , , 463 466 and and CC 467 475 IFN-beta IFN-beta NNP 476 485 inhibited inhibit VBD 486 490 IL-2 il-2 NN 491 502 deprivation deprivation NN 503 512 apoptosis apoptosis NN 513 515 in in IN 516 519 Th0 Th0 NNP 519 520 , , , 521 524 Th1 Th1 NNP 524 525 , , , 526 529 and and CC 530 533 Th2 th2 NN 534 540 clones clone NNS 540 541 . . . 542 544 We we PRP 545 549 also also RB 550 555 found find VBD 556 560 that that IN 561 565 IL-2 il-2 NN 566 574 protects protect VBZ 575 576 T t NN 577 581 cell cell NN 582 588 clones clone NNS 589 593 from from IN 594 598 IL-2 il-2 NN 599 610 deprivation deprivation NN 611 620 apoptosis apoptosis NN 621 633 accompanying accompany VBG 634 640 active active JJ 641 654 proliferation proliferation NN 655 658 and and CC 659 667 enhanced enhance VBN 668 678 expression expression NN 679 681 of of IN 682 685 P53 P53 NNP 685 686 , , , 687 689 Rb Rb NNP 690 693 and and CC 694 700 Bcl-xL Bcl-xL NNP 701 709 proteins protein NNS 709 710 . . . 711 713 In in IN 714 722 contrast contrast NN 722 723 , , , 724 738 IFN-alpha/beta IFN-alpha/beta NNP 739 746 rescued rescue VBD 747 748 T t NN 749 753 cell cell NN 754 760 clones clone NNS 761 765 from from IN 766 775 apoptosis apoptosis NN 776 783 without without IN 784 790 active active JJ 791 804 proliferation proliferation NN 804 805 , , , 806 809 and and CC 810 820 expression expression NN 821 823 of of IN 824 844 apoptosis-associated apoptosis-associated JJ 845 853 proteins protein NNS 854 860 tested test VBN 861 863 so so RB 864 867 far far RB 868 871 was be VBD 872 882 unaffected unaffected JJ 882 883 . . . 884 888 This this DT 889 892 may may MD 893 895 be be VB 896 899 due due JJ 900 902 to to TO 903 906 the the DT 907 911 fact fact NN 912 916 that that IN 917 918 T t NN 919 924 cells cell NNS 925 932 treated treat VBN 933 937 with with IN 938 942 IL-2 il-2 NN 943 952 contained contain VBD 953 958 those those DT 959 966 located located JJ 967 969 in in IN 970 971 S S NNP 972 973 + + SYM 974 978 G2/M G2/M NNP 979 985 phases phase NNS 986 988 of of IN 989 992 the the DT 993 997 cell cell NN 998 1003 cycle cycle NN 1003 1004 , , , 1005 1012 whereas whereas IN 1013 1016 the the DT 1017 1021 vast vast JJ 1022 1030 majority majority NN 1031 1033 of of IN 1034 1035 T t NN 1036 1041 cells cell NNS 1042 1049 treated treat VBN 1050 1054 with with IN 1055 1069 IFN-alpha/beta IFN-alpha/beta NNP 1070 1074 were be VBD 1075 1082 located locate VBN 1083 1085 in in IN 1086 1091 G0/G1 g0/g1 NN 1092 1097 phase phase NN 1097 1098 . . . 1099 1113 IFN-alpha/beta IFN-alpha/beta NNP 1114 1126 specifically specifically RB 1127 1134 induced induce VBD 1135 1143 tyrosine tyrosine NN 1144 1159 phosphorylation phosphorylation NN 1160 1163 and and CC 1164 1177 translocation translocation NN 1178 1182 into into IN 1183 1190 nucleus nucleus NN 1191 1193 of of IN 1194 1200 signal signal NN 1201 1212 transducers transducer NNS 1213 1216 and and CC 1217 1227 activators activator NNS 1228 1230 of of IN 1231 1244 transcription transcription NN 1245 1246 ( ( ( 1246 1250 STAT STAT NNP 1250 1251 ) ) ) 1252 1253 2 2 CD 1254 1261 protein protein NN 1262 1264 in in IN 1265 1268 the the DT 1269 1270 T t NN 1271 1275 cell cell NN 1276 1282 clones clone NNS 1282 1283 . . . 1284 1286 In in IN 1287 1295 addition addition NN 1295 1296 , , , 1297 1312 over-expression over-expression NN 1313 1315 of of IN 1316 1321 STAT2 stat2 NN 1322 1324 by by IN 1325 1337 transfection transfection NN 1338 1340 of of IN 1341 1344 the the DT 1345 1349 cDNA cdna NN 1350 1359 prevented prevent VBD 1360 1369 apoptosis apoptosis NN 1370 1372 of of IN 1373 1376 the the DT 1377 1378 T t NN 1379 1383 cell cell NN 1384 1390 clones clone NNS 1390 1391 . . . 1392 1395 Our our PRP$ 1396 1403 present present JJ 1404 1409 study study NN 1410 1415 shows show VBZ 1416 1420 that that IN 1421 1430 IFN-alpha IFN-alpha NNP 1431 1434 and and CC 1435 1440 -beta -beta NN 1441 1448 mediate mediate VBP 1449 1463 anti-apoptotic anti-apoptotic JJ 1464 1470 effect effect NN 1471 1478 through through IN 1479 1484 other other JJ 1485 1493 pathways pathway NNS 1494 1498 than than IN 1499 1503 that that DT 1504 1506 of of IN 1507 1511 IL-2 il-2 NN 1512 1514 in in IN 1515 1521 growth growth NN 1522 1528 factor factor NN 1529 1540 deprivation deprivation NN 1541 1550 apoptosis apoptosis NN 1550 1551 . . .