0 11 Association Association NNP 12 19 between between IN 20 30 expression expression NN 31 33 of of IN 34 47 intercellular intercellular JJ 48 56 adhesion adhesion NN 57 67 molecule-1 molecule-1 NN 68 71 and and CC 72 83 integration integration NN 84 86 of of IN 87 92 human human JJ 93 108 T-cell-leukemia t-cell-leukemia JJ 109 114 virus virus NN 115 119 type type NN 120 121 1 1 CD 122 124 in in IN 125 130 adult adult JJ 131 137 T-cell t-cell NN 138 146 leukemia leukemia NN 147 152 cells cell NNS 152 153 . . . 155 157 It it PRP 158 160 is be VBZ 161 166 known know VBN 167 171 that that IN 172 175 the the DT 176 186 expression expression NN 187 193 levels level NNS 194 196 of of IN 197 210 intercellular intercellular JJ 211 219 adhesion adhesion NN 220 230 molecule-1 molecule-1 NN 231 232 ( ( ( 232 238 ICAM-1 icam-1 NN 238 239 ) ) ) 240 242 in in IN 243 248 adult adult JJ 249 250 T t NN 251 255 cell cell NN 256 269 leukemia(ATL) leukemia(atl) NN 270 275 cells cell NNS 276 279 are be VBP 280 284 high high JJ 284 285 , , , 286 293 whereas whereas IN 294 299 those those DT 300 302 in in IN 303 313 T-lymphoid t-lymphoid NN 314 319 cells cell NNS 320 323 are be VBP 324 327 not not RB 327 328 . . . 329 331 In in IN 332 337 order order NN 338 340 to to TO 341 352 investigate investigate VB 353 356 the the DT 357 364 factors factor NNS 365 369 that that WDT 370 379 influence influence VBP 380 383 the the DT 384 393 induction induction NN 394 396 of of IN 397 403 ICAM-1 icam-1 NN 404 413 molecules molecule NNS 413 414 , , , 415 423 Northern northern NN 424 428 blot blot NN 429 437 analysis analysis NN 438 440 to to TO 441 448 measure measure VB 449 452 the the DT 453 463 expression expression NN 464 469 level level NN 470 472 of of IN 473 479 ICAM-1 icam-1 NN 480 485 mRNAs mrna NNS 486 489 and and CC 490 498 Southern southern JJ 499 503 blot blot NN 504 517 hybridization hybridization NN 518 520 to to TO 521 528 analyze analyze VB 529 532 the the DT 533 544 integration integration NN 545 547 of of IN 548 553 human human JJ 554 569 T-cell-leukemia t-cell-leukemia JJ 570 575 virus virus NN 576 580 type type NN 581 582 1 1 CD 583 584 ( ( ( 584 590 HTLV-1 htlv-1 NN 590 591 ) ) ) 592 600 provirus provirus NN 601 605 were be VBD 606 610 done do VBN 610 611 . . . 612 615 The the DT 616 622 levels level NNS 623 625 of of IN 626 632 ICAM-1 icam-1 NN 633 637 mRNA mrna NN 638 648 expression expression NN 649 651 of of IN 652 655 ATL ATL NNP 656 661 cells cell NNS 662 666 were be VBD 667 676 generally generally RB 677 683 higher high JJR 684 688 than than IN 689 694 those those DT 695 697 of of IN 698 708 T-lymphoid t-lymphoid NN 709 714 cells cell NNS 714 715 . . . 716 723 However however RB 723 724 , , , 725 732 ILT-mat ILT-mat NNP 733 738 cells cell NNS 739 742 and and CC 743 752 ATL16T(-) atl16t(-) JJ 753 758 cells cell NNS 758 759 , , , 760 768 although although IN 769 773 they they PRP 774 778 were be VBD 779 782 ATL atl NN 783 788 cells cell NNS 788 789 , , , 790 796 showed show VBD 797 803 rather rather RB 804 807 low low JJ 808 815 surface surface NN 816 822 ICAM-1 icam-1 NN 823 833 expression expression NN 834 837 and and CC 838 844 ICAM-1 icam-1 NN 845 849 mRNA mrna NN 850 860 expression expression NN 860 861 . . . 862 870 Southern Southern NNP 871 875 blot blot NN 876 889 hybridization hybridization NN 890 896 showed show VBD 897 901 that that IN 902 906 only only RB 907 910 two two CD 911 914 and and CC 915 919 four four CD 920 925 bands band NNS 926 930 were be VBD 931 936 found find VBN 937 939 in in IN 940 947 ILT-mat ILT-mat NNP 948 951 and and CC 952 961 ATL16T(-) atl16t(-) NN 962 967 cells cell NNS 967 968 , , , 969 981 respectively respectively RB 981 982 , , , 983 990 whereas whereas IN 991 992 > > JJR 993 995 10 10 CD 996 1001 bands band NNS 1002 1006 were be VBD 1007 1015 detected detect VBN 1016 1018 in in IN 1019 1024 other other JJ 1025 1028 ATL ATL NNP 1029 1034 cells cell NNS 1034 1035 . . . 1036 1041 These these DT 1042 1049 results result NNS 1050 1057 suggest suggest VBP 1058 1062 that that IN 1063 1073 monoclonal monoclonal JJ 1074 1085 integration integration NN 1086 1088 of of IN 1089 1095 HTLV-1 htlv-1 NN 1096 1104 provirus provirus NN 1105 1107 to to TO 1108 1111 the the DT 1112 1118 genome genome NN 1119 1121 of of IN 1122 1123 T t NN 1124 1128 cell cell NN 1128 1129 , , , 1130 1140 especially especially RB 1141 1144 the the DT 1145 1151 number number NN 1152 1154 of of IN 1155 1166 integration integration NN 1167 1172 sites site NNS 1172 1173 , , , 1174 1176 is be VBZ 1177 1180 one one CD 1181 1183 of of IN 1184 1187 the the DT 1188 1195 factors factor NNS 1196 1199 for for IN 1200 1209 induction induction NN 1210 1212 of of IN 1213 1219 ICAM-1 icam-1 NN 1220 1229 molecules molecule NNS 1229 1230 . . .