0 9 Induction Induction NNP 10 12 of of IN 13 18 human human JJ 19 35 immunodeficiency immunodeficiency NN 36 41 virus virus NN 42 46 type type NN 47 48 1 1 CD 49 59 expression expression NN 60 62 in in IN 63 72 monocytic monocytic JJ 73 78 cells cell NNS 79 81 by by IN 82 94 Cryptococcus cryptococcus FW 95 105 neoformans neoformans FW 106 109 and and CC 110 117 Candida Candida NNP 118 126 albicans albicans NNP 126 127 . . . 129 136 Because because IN 137 148 candidiasis candidiasis NN 149 152 and and CC 153 167 cryptococcosis cryptococcosis NN 168 171 are be VBP 172 178 common common JJ 179 181 in in IN 182 187 human human JJ 188 204 immunodeficiency immunodeficiency NN 205 210 virus virus NN 211 212 ( ( ( 212 225 HIV)-infected hiv)-infected JJ 226 233 persons person NNS 233 234 , , , 235 238 the the DT 239 245 effect effect NN 246 248 of of IN 249 261 Cryptococcus cryptococcus FW 262 272 neoformans neoformans FW 273 276 and and CC 277 284 Candida candida FW 285 293 albicans albicans FW 294 296 on on IN 297 300 HIV HIV NNP 301 311 expression expression NN 312 314 in in IN 315 324 monocytic monocytic JJ 325 330 cells cell NNS 331 334 was be VBD 335 343 examined examine VBN 343 344 . . . 345 356 Stimulation stimulation NN 357 359 of of IN 360 363 the the DT 364 372 latently latently RB 373 385 HIV-infected hiv-infected JJ 386 400 myelomonocytic myelomonocytic JJ 401 405 cell cell NN 406 410 line line NN 411 418 OM-10.1 om-10.1 NN 419 423 with with IN 424 426 C. c. FW 427 437 neoformans neoformans FW 438 441 and and CC 442 444 C. c. FW 445 453 albicans albicans FW 454 456 in in IN 457 460 the the DT 461 469 presence presence NN 470 472 of of IN 473 479 pooled pool VBN 480 485 human human JJ 486 491 serum serum NN 492 498 caused cause VBD 499 500 a a DT 501 516 ratio-dependent ratio-dependent JJ 517 525 increase increase NN 526 528 in in IN 529 532 HIV HIV NNP 533 543 production production NN 543 544 . . . 545 554 Induction Induction NNP 555 557 of of IN 558 561 HIV HIV NNP 562 564 by by IN 565 567 C. c. FW 568 578 neoformans neoformans FW 579 582 was be VBD 583 591 enhanced enhance VBN 592 594 by by IN 595 608 anti-capsular anti-capsular JJ 609 617 antibody antibody NN 617 618 , , , 619 624 while while IN 625 634 induction induction NN 635 637 by by IN 638 642 both both DT 643 652 organisms organism NNS 653 656 was be VBD 657 666 inhibited inhibit VBN 667 669 by by IN 670 684 anti-TNF-alpha anti-tnf-alpha JJ 685 693 antibody antibody NN 693 694 . . . 695 697 In in IN 698 703 THP-1 thp-1 NN 704 709 cells cell NNS 710 721 transfected transfecte VBN 722 726 with with IN 727 730 HIV HIV NNP 731 738 plasmid plasmid NN 739 749 constructs construct NNS 749 750 , , , 751 755 both both DT 756 765 organisms organism NNS 766 773 induced induce VBD 774 787 transcription transcription NN 788 792 from from IN 793 796 the the DT 797 800 HIV HIV NNP 801 805 long long JJ 806 814 terminal terminal JJ 815 821 repeat repeat NN 822 826 that that WDT 827 830 was be VBD 831 840 dependent dependent JJ 841 843 on on IN 844 850 intact intact JJ 851 860 NF-kappaB NF-kappaB NNP 861 868 binding binding NN 869 878 sequences sequence NNS 878 879 . . . 880 884 Thus thus RB 884 885 , , , 886 888 C. c. FW 889 899 neoformans neoformans FW 900 903 and and CC 904 906 C. c. FW 907 915 albicans albicans FW 916 923 enhance enhance VBP 924 927 HIV HIV NNP 928 938 expression expression NN 939 941 in in IN 942 951 monocytic monocytic JJ 952 957 cells cell NNS 958 965 through through IN 966 967 a a DT 968 978 TNF-alpha- TNF-alpha- NNP 979 982 and and CC 983 1002 NF-kappaB-dependent nf-kappab-dependent JJ 1003 1012 mechanism mechanism NN 1012 1013 . . . 1014 1016 In in IN 1017 1029 HIV-infected hiv-infected JJ 1030 1038 patients patient NNS 1038 1039 , , , 1040 1044 such such JJ 1045 1056 enhancement enhancement NN 1057 1060 may may MD 1061 1068 further further RB 1069 1075 impair impair VB 1076 1080 host host NN 1081 1089 immunity immunity NN 1090 1093 and and CC 1094 1099 could could MD 1100 1110 accelerate accelerate VB 1111 1114 the the DT 1115 1121 course course NN 1122 1124 of of IN 1125 1128 HIV HIV NNP 1129 1136 disease disease NN 1136 1137 . . .