0	11	Cyclosporin	Cyclosporin	NNP
12	13	A	A	NNP
14	24	interferes	interfere	VBZ
25	29	with	with	IN
30	33	the	the	DT
34	43	inducible	inducible	JJ
44	55	degradation	degradation	NN
56	58	of	of	IN
59	67	NF-kappa	NF-kappa	NNP
68	69	B	B	NNP
70	80	inhibitors	inhibitor	NNS
80	81	,	,	,
82	85	but	but	CC
86	89	not	not	RB
90	94	with	with	IN
95	98	the	the	DT
99	109	processing	processing	NN
110	112	of	of	IN
113	126	p105/NF-kappa	p105/nf-kappa	NN
127	129	B1	b1	NN
130	132	in	in	IN
133	134	T	t	NN
135	140	cells	cell	NNS
140	141	.	.	.

143	146	The	the	DT
147	160	transcription	transcription	NN
161	167	factor	factor	NN
168	176	NF-kappa	NF-kappa	NNP
177	178	B	B	NNP
179	187	controls	control	VBZ
188	191	the	the	DT
192	201	induction	induction	NN
202	204	of	of	IN
205	213	numerous	numerous	JJ
214	222	cytokine	cytokine	NN
223	232	promoters	promoter	NNS
233	239	during	during	IN
240	243	the	the	DT
244	254	activation	activation	NN
255	257	of	of	IN
258	259	T	t	NN
260	271	lymphocytes	lymphocyte	NNS
271	272	.	.	.

273	283	Inhibition	Inhibition	NNP
284	286	of	of	IN
287	288	T	t	NN
289	293	cell	cell	NN
294	304	activation	activation	NN
305	307	by	by	IN
308	311	the	the	DT
312	330	immunosuppressants	immunosuppressant	NNS
331	342	cyclosporin	cyclosporin	NN
343	344	A	a	NN
345	346	(	(	(
346	349	CsA	CsA	NNP
349	350	)	)	)
351	354	and	and	CC
355	360	FK506	FK506	NNP
361	367	exerts	exert	VBZ
368	369	a	a	DT
370	381	suppressive	suppressive	JJ
382	388	effect	effect	NN
389	391	on	on	IN
392	395	the	the	DT
396	405	induction	induction	NN
406	408	of	of	IN
409	414	these	these	DT
415	423	NF-kappa	NF-kappa	NNP
424	436	B-controlled	b-controlled	JJ
437	445	cytokine	cytokine	NN
446	455	promoters	promoter	NNS
455	456	.	.	.

457	459	We	we	PRP
460	464	show	show	VBP
465	468	for	for	IN
469	474	human	human	JJ
475	481	Jurkat	Jurkat	NNP
482	483	T	t	NN
484	492	leukemia	leukemia	NN
493	498	cells	cell	NNS
498	499	,	,	,
500	502	as	as	RB
503	507	well	well	RB
508	510	as	as	IN
511	516	human	human	JJ
517	520	and	and	CC
521	526	mouse	mouse	NN
527	534	primary	primary	JJ
535	536	T	t	NN
537	548	lymphocytes	lymphocyte	NNS
548	549	,	,	,
550	554	that	that	IN
555	559	this	this	DT
560	570	inhibitory	inhibitory	JJ
571	577	effect	effect	NN
578	580	is	be	VBZ
581	592	accompanied	accompany	VBN
593	595	by	by	IN
596	598	an	an	DT
599	607	impaired	impaired	JJ
608	615	nuclear	nuclear	JJ
616	629	translocation	translocation	NN
630	632	of	of	IN
633	636	the	the	DT
637	640	Rel	Rel	NNP
641	649	proteins	protein	NNS
650	655	c-Rel	c-rel	NN
655	656	,	,	,
657	665	RelA/p65	RelA/p65	NNP
666	669	and	and	CC
670	678	NF-kappa	NF-kappa	NNP
679	685	B1/p50	B1/p50	NNP
685	686	,	,	,
687	694	whereas	whereas	IN
695	698	the	the	DT
699	706	nuclear	nuclear	JJ
707	717	appearance	appearance	NN
718	720	of	of	IN
721	725	RelB	RelB	NNP
726	733	remains	remain	VBZ
734	744	unaffected	unaffected	JJ
744	745	.	.	.

746	749	CsA	CsA	NNP
750	754	does	do	VBZ
755	758	not	not	RB
759	768	interfere	interfere	VB
769	773	with	with	IN
774	777	the	the	DT
778	787	synthesis	synthesis	NN
788	790	of	of	IN
791	794	Rel	Rel	NNP
795	803	proteins	protein	NNS
803	804	,	,	,
805	808	but	but	CC
809	817	prevents	prevent	VBZ
818	821	the	the	DT
822	831	inducible	inducible	JJ
832	843	degradation	degradation	NN
844	846	of	of	IN
847	856	cytosolic	cytosolic	JJ
857	865	NF-kappa	NF-kappa	NNP
866	867	B	B	NNP
868	878	inhibitors	inhibitor	NNS
879	880	I	i	NN
881	886	kappa	kappa	NN
887	888	B	B	NNP
889	894	alpha	alpha	NN
895	898	and	and	CC
899	900	I	i	NN
901	906	kappa	kappa	NN
907	908	B	B	NNP
909	913	beta	beta	NN
914	918	upon	upon	IN
919	920	T	t	NN
921	925	cell	cell	NN
926	936	activation	activation	NN
936	937	.	.	.

938	941	CsA	CsA	NNP
942	949	neither	neither	CC
950	958	inhibits	inhibit	VBZ
959	962	the	the	DT
963	973	processing	processing	NN
974	976	of	of	IN
977	980	the	the	DT
981	989	NF-kappa	NF-kappa	NNP
990	992	B1	B1	NNP
993	1002	precursor	precursor	NN
1003	1007	p105	p105	NN
1008	1010	to	to	TO
1011	1014	p50	p50	NN
1014	1015	,	,	,
1016	1019	nor	nor	CC
1020	1024	does	do	VBZ
1025	1027	it	it	PRP
1028	1029	“	``	``
1029	1038	stabilize	stabilize	VB
1038	1039	”	''	''
1040	1043	the	the	DT
1044	1054	C-terminal	c-terminal	JJ
1055	1062	portion	portion	NN
1063	1065	of	of	IN
1066	1070	p105	p105	NN
1070	1071	,	,	,
1072	1073	I	i	NN
1074	1079	kappa	kappa	NN
1080	1081	B	B	NNP
1082	1087	gamma	gamma	NN
1087	1088	,	,	,
1089	1094	which	which	WDT
1095	1097	is	be	VBZ
1098	1106	degraded	degrade	VBN
1107	1113	during	during	IN
1114	1118	p105	p105	NN
1119	1129	processing	processing	NN
1130	1132	to	to	TO
1133	1139	mature	mature	JJ
1140	1143	p50	p50	NN
1143	1144	.	.	.

1145	1150	These	these	DT
1151	1158	results	result	NNS
1159	1167	indicate	indicate	VBP
1168	1172	that	that	IN
1173	1176	CsA	CsA	NNP
1177	1187	interferes	interfere	VBZ
1188	1192	with	with	IN
1193	1194	a	a	DT
1195	1203	specific	specific	JJ
1204	1209	event	event	NN
1210	1212	in	in	IN
1213	1216	the	the	DT
1217	1231	signal-induced	signal-induced	JJ
1232	1243	degradation	degradation	NN
1244	1246	of	of	IN
1247	1248	I	i	NN
1249	1254	kappa	kappa	NN
1255	1256	B	B	NNP
1257	1262	alpha	alpha	NN
1263	1266	and	and	CC
1267	1268	I	i	NN
1269	1274	kappa	kappa	NN
1275	1276	B	B	NNP
1277	1281	beta	beta	NN
1281	1282	,	,	,
1283	1286	but	but	CC
1287	1291	does	do	VBZ
1292	1295	not	not	RB
1296	1302	affect	affect	VB
1303	1306	the	the	DT
1307	1317	processing	processing	NN
1318	1320	of	of	IN
1321	1329	NF-kappa	NF-kappa	NNP
1330	1337	B1/p105	b1/p105	NN
1338	1340	to	to	TO
1341	1344	p50	p50	NN
1344	1345	.	.	.