0 13 Transcription transcription NN 14 21 factors factor NNS 22 24 in in IN 25 40 immune-mediated immune-mediated JJ 41 48 disease disease NN 48 49 . . . 51 52 A a DT 53 58 large large JJ 59 65 amount amount NN 66 68 of of IN 69 77 detailed detailed JJ 78 89 information information NN 90 95 about about IN 96 99 the the DT 100 113 intracellular intracellular JJ 114 122 proteins protein NNS 123 133 regulating regulate VBG 134 142 NF-kappa NF-kappa NNP 143 144 B B NNP 145 155 activation activation NN 156 159 and and CC 160 163 the the DT 164 172 cellular cellular JJ 173 181 response response NN 182 184 to to TO 185 193 NF-kappa NF-kappa NNP 194 195 B B NNP 196 206 activation activation NN 207 210 has have VBZ 211 218 emerged emerge VBN 219 227 recently recently RB 227 228 . . . 229 236 Several several JJ 237 242 small small JJ 243 252 molecules molecule NNS 252 253 , , , 254 256 an an DT 257 266 antisense antisense JJ 267 282 oligonucleotide oligonucleotide NN 282 283 , , , 284 287 and and CC 288 292 gene gene NN 293 304 therapeutic therapeutic JJ 305 311 agents agent NNS 312 316 that that WDT 317 324 inhibit inhibit VBP 325 333 NF-kappa NF-kappa NNP 334 335 b b NN 336 346 activation activation NN 347 351 have have VBP 352 356 been be VBN 357 366 described describe VBN 366 367 . . . 368 375 Despite despite IN 376 380 this this DT 380 381 , , , 382 387 there there EX 388 391 are be VBP 392 397 still still RB 398 409 significant significant JJ 410 414 gaps gap NNS 415 417 in in IN 418 421 our our PRP$ 422 435 understanding understanding NN 436 438 of of IN 439 443 this this DT 444 451 process process NN 452 455 and and CC 456 459 its its PRP$ 460 472 consequences consequence NNS 472 473 . . . 474 476 In in IN 477 485 contrast contrast NN 485 486 , , , 487 490 the the DT 491 507 characterization characterization NN 508 510 of of IN 511 524 transcription transcription NN 525 532 factors factor NNS 533 544 selectively selectively RB 545 555 regulating regulate VBG 556 564 cytokine cytokine NN 565 575 production production NN 576 578 by by IN 579 583 CD4+ cd4+ JJ 584 585 T t NN 586 590 cell cell NN 591 598 subsets subset NNS 599 601 is be VBZ 602 604 at at IN 605 606 a a DT 607 611 very very RB 612 617 early early JJ 618 623 stage stage NN 623 624 . . . 625 630 Three three CD 631 642 interacting interact VBG 643 651 proteins protein NNS 652 656 have have VBP 657 665 recently recently RB 666 670 been be VBN 671 676 shown show VBN 677 679 to to TO 680 690 contribute contribute VB 691 693 to to TO 694 711 subset-restricted subset-restricted JJ 712 722 expression expression NN 723 725 of of IN 726 729 the the DT 730 734 IL-4 il-4 NN 735 739 gene gene NN 739 740 . . . 741 746 There there EX 747 750 are be VBP 751 756 other other JJ 757 765 elements element NNS 766 776 regulating regulate VBG 777 781 IL-4 il-4 NN 782 786 gene gene NN 787 797 expression expression NN 797 798 , , , 799 806 however however RB 806 807 , , , 808 811 and and CC 812 815 the the DT 816 824 relative relative JJ 825 835 importance importance NN 836 838 of of IN 839 844 these these DT 845 853 recently recently RB 854 864 identified identify VBN 865 873 proteins protein NNS 874 877 has have VBZ 878 881 yet yet RB 882 884 to to TO 885 887 be be VB 888 898 determined determine VBN 898 899 . . .