0 10 Activation Activation NNP 11 13 of of IN 14 27 transcription transcription NN 28 34 factor factor NN 35 43 NF-kappa NF-kappa NNP 44 45 B B NNP 46 48 by by IN 49 59 phagocytic phagocytic JJ 60 67 stimuli stimulus NNS 68 70 in in IN 71 76 human human JJ 77 88 neutrophils neutrophil NNS 88 89 . . . 91 103 Phagocytosis Phagocytosis NNP 104 114 represents represent VBZ 115 117 an an DT 118 127 important important JJ 128 141 physiological physiological JJ 142 149 trigger trigger NN 150 153 for for IN 154 157 the the DT 158 167 inducible inducible JJ 168 178 expression expression NN 179 181 of of IN 182 189 several several JJ 190 195 genes gene NNS 196 198 in in IN 199 204 human human JJ 205 216 neutrophils neutrophil NNS 216 217 . . . 218 222 Here here RB 222 223 , , , 224 226 we we PRP 227 233 report report VBP 234 238 that that IN 239 240 a a DT 241 252 DNA-binding dna-binding JJ 253 261 activity activity NN 262 271 primarily primarily RB 272 282 consisting consist VBG 283 285 of of IN 286 289 the the DT 290 299 classical classical JJ 300 308 NF-kappa NF-kappa NNP 309 310 B B NNP 311 322 heterodimer heterodimer NN 322 323 , , , 324 332 p50/RelA p50/RelA NNP 332 333 , , , 334 336 is be VBZ 337 344 induced induce VBN 345 347 in in IN 348 361 phagocytosing phagocytose VBG 362 373 neutrophils neutrophil NNS 373 374 . . . 375 380 Under under IN 381 386 these these DT 387 397 conditions condition NNS 397 398 , , , 399 407 NF-kappa NF-kappa NNP 408 409 B B NNP 410 420 activation activation NN 421 424 was be VBD 425 430 found find VBN 431 433 to to TO 434 436 be be VB 437 438 a a DT 439 444 rapid rapid JJ 445 448 and and CC 449 458 transient transient JJ 459 467 response response NN 467 468 , , , 469 477 reaching reach VBG 478 479 a a DT 480 487 maximum maximum NN 488 490 by by IN 491 496 10-15 10-15 CD 497 500 min min NN 500 501 , , , 502 505 and and CC 506 515 returning return VBG 516 518 to to TO 519 529 near-basal near-basal JJ 530 536 levels level NNS 537 539 by by IN 540 542 30 30 CD 543 546 min min NN 546 547 . . . 548 550 In in IN 551 562 neutrophils neutrophil NNS 563 573 undergoing undergo VBG 574 577 the the DT 578 590 phagocytosis phagocytosis NN 591 593 of of IN 594 603 opsonized opsonize VBN 604 610 yeasts yeast NNS 610 611 , , , 612 615 the the DT 616 621 onset onset NN 622 624 of of IN 625 633 NF-kappa NF-kappa NNP 634 635 B B NNP 636 646 activation activation NN 647 650 was be VBD 651 661 paralleled parallel VBN 662 664 by by IN 665 666 a a DT 667 674 decline decline NN 675 677 in in IN 678 692 immunoreactive immunoreactive JJ 693 694 I i NN 695 700 kappa kappa NN 701 708 B-alpha B-alpha NNP 709 716 protein protein NN 717 723 levels level NNS 723 724 , , , 725 728 and and CC 729 732 the the DT 733 741 cellular cellular JJ 742 743 I i NN 744 749 kappa kappa NN 750 757 B-alpha B-alpha NNP 758 762 pool pool NN 763 766 was be VBD 767 778 replenished replenish VBN 779 781 by by IN 782 784 30 30 CD 785 788 min min NN 788 789 , , , 790 792 in in IN 793 802 agreement agreement NN 803 807 with with IN 808 811 our our PRP$ 812 815 gel gel NN 816 821 shift shift NN 822 826 data datum NNS 826 827 . . . 828 830 We we PRP 831 839 conclude conclude VBP 840 844 that that IN 845 853 NF-kappa NF-kappa NNP 854 855 B B NNP 856 866 activation activation NN 867 872 could could MD 873 883 constitute constitute VB 884 887 one one CD 888 890 of of IN 891 894 the the DT 895 905 mechanisms mechanism NNS 906 913 whereby whereby WRB 914 917 the the DT 918 928 expression expression NN 929 931 of of IN 932 937 kappa kappa NN 938 950 B-responsive b-responsive JJ 951 956 genes gene NNS 957 959 is be VBZ 960 968 enhanced enhance VBN 969 971 in in IN 972 985 phagocytosing phagocytose VBG 986 997 neutrophils neutrophil NNS 997 998 . . . 999 1001 To to TO 1002 1005 our our PRP$ 1006 1015 knowledge knowledge NN 1015 1016 , , , 1017 1021 this this DT 1022 1032 represents represent VBZ 1033 1036 the the DT 1037 1042 first first JJ 1043 1056 demonstration demonstration NN 1057 1061 that that IN 1062 1072 phagocytic phagocytic JJ 1073 1080 stimuli stimulus NNS 1081 1084 can can MD 1085 1091 induce induce VB 1092 1100 NF-kappa NF-kappa NNP 1101 1102 B B NNP 1103 1113 activation activation NN 1114 1116 in in IN 1117 1122 human human JJ 1123 1134 neutrophils neutrophil NNS 1134 1135 . . .