0	8	Distinct	distinct	JJ
9	19	mechanisms	mechanism	NNS
20	23	for	for	IN
24	40	N-acetylcysteine	N-acetylcysteine	NNP
41	51	inhibition	inhibition	NN
52	54	of	of	IN
55	71	cytokine-induced	cytokine-induced	JJ
72	82	E-selectin	E-selectin	NNP
83	86	and	and	CC
87	93	VCAM-1	vcam-1	NN
94	104	expression	expression	NN
104	105	.	.	.

107	109	We	we	PRP
110	114	have	have	VBP
115	123	examined	examine	VBN
124	127	the	the	DT
128	135	effects	effect	NNS
136	138	of	of	IN
139	158	N-acetyl-L-cysteine	N-acetyl-L-cysteine	NNP
159	160	(	(	(
160	163	NAC	NAC	NNP
163	164	)	)	)
164	165	,	,	,
166	167	a	a	DT
168	186	well-characterized	well-characterized	JJ
186	187	,	,	,
188	204	thiol-containing	thiol-containing	JJ
205	216	antioxidant	antioxidant	NN
216	217	,	,	,
218	220	on	on	IN
221	236	agonist-induced	agonist-induced	JJ
237	246	monocytic	monocytic	JJ
247	251	cell	cell	NN
252	260	adhesion	adhesion	NN
261	263	to	to	TO
264	275	endothelial	endothelial	JJ
276	281	cells	cell	NNS
282	283	(	(	(
283	287	EC).	EC).	NNP
288	291	NAC	NAC	NNP
292	301	inhibited	inhibit	VBD
302	315	interleukin-1	interleukin-1	NN
316	317	(	(	(
317	321	IL-1	il-1	NN
322	335	beta)-induced	beta)-induced	JJ
335	336	,	,	,
337	340	but	but	CC
341	344	not	not	RB
345	350	basal	basal	JJ
350	351	,	,	,
352	360	adhesion	adhesion	NN
361	365	with	with	IN
366	368	50	50	CD
368	369	%	%	NN
370	380	inhibition	inhibition	NN
381	383	at	at	IN
384	397	approximately	approximately	RB
398	400	20	20	CD
401	403	mM	mm	NN
403	404	.	.	.

405	414	Monocytic	monocytic	JJ
415	419	cell	cell	NN
420	428	adhesion	adhesion	NN
429	431	to	to	TO
432	434	EC	EC	NNP
435	437	in	in	IN
438	446	response	response	NN
447	449	to	to	TO
450	455	tumor	tumor	NN
456	464	necrosis	necrosis	NN
465	477	factor-alpha	factor-alpha	NN
478	479	(	(	(
479	488	TNF-alpha	TNF-alpha	NNP
488	489	)	)	)
489	490	,	,	,
491	509	lipopolysaccharide	lipopolysaccharide	NN
510	511	(	(	(
511	514	LPS	LPS	NNP
514	515	)	)	)
515	516	,	,	,
517	531	alpha-thrombin	alpha-thrombin	NN
531	532	,	,	,
533	535	or	or	CC
536	543	phorbol	phorbol	NN
544	556	12-myristate	12-myristate	NN
557	567	13-acetate	13-acetate	NN
568	569	(	(	(
569	572	PMA	PMA	NNP
572	573	)	)	)
574	577	was	be	VBD
578	587	similarly	similarly	RB
588	597	inhibited	inhibit	VBN
598	600	by	by	IN
601	604	NAC	NAC	NNP
604	605	.	.	.

606	612	Unlike	unlike	IN
613	622	published	publish	VBN
623	630	studies	study	NNS
631	635	with	with	IN
636	662	pyrrolidinedithiocarbamate	pyrrolidinedithiocarbamate	NN
662	663	,	,	,
664	669	which	which	WDT
670	682	specifically	specifically	RB
683	692	inhibited	inhibit	VBD
693	701	vascular	vascular	JJ
702	706	cell	cell	NN
707	715	adhesion	adhesion	NN
716	724	molecule	molecule	NN
725	726	1	1	CD
727	728	(	(	(
728	734	VCAM-1	vcam-1	NN
734	735	)	)	)
735	736	,	,	,
737	740	NAC	NAC	NNP
741	750	inhibited	inhibit	VBD
751	755	IL-1	il-1	NN
756	768	beta-induced	beta-induced	JJ
769	773	mRNA	mrna	NN
774	777	and	and	CC
778	782	cell	cell	NN
783	790	surface	surface	NN
791	801	expression	expression	NN
802	804	of	of	IN
805	809	both	both	CC
810	820	E-selectin	E-selectin	NNP
821	824	and	and	CC
825	831	VCAM-1	VCAM-1	NNP
831	832	.	.	.

833	836	NAC	NAC	NNP
837	840	had	have	VBD
841	843	no	no	DT
844	850	effect	effect	NN
851	853	on	on	IN
854	857	the	the	DT
858	867	half-life	half-life	NN
868	870	of	of	IN
871	881	E-selectin	E-selectin	NNP
882	884	or	or	CC
885	891	VCAM-1	VCAM-1	NNP
892	896	mRNA	mRNA	NNP
896	897	.	.	.

898	906	Although	although	IN
907	910	NAC	NAC	NNP
911	918	reduced	reduce	VBD
919	926	nuclear	nuclear	JJ
927	939	factor-kappa	factor-kappa	NN
940	941	B	B	NNP
942	943	(	(	(
943	951	NF-kappa	NF-kappa	NNP
952	953	B	B	NNP
953	954	)	)	)
955	965	activation	activation	NN
966	968	in	in	IN
969	971	EC	EC	NNP
972	974	as	as	IN
975	983	measured	measure	VBN
984	986	by	by	IN
987	996	gel-shift	gel-shift	JJ
997	1003	assays	assay	NNS
1004	1009	using	use	VBG
1010	1012	an	an	DT
1013	1028	oligonucleotide	oligonucleotide	NN
1029	1034	probe	probe	NN
1035	1048	corresponding	correspond	VBG
1049	1051	to	to	TO
1052	1055	the	the	DT
1056	1065	consensus	consensus	NN
1066	1074	NF-kappa	NF-kappa	NNP
1075	1076	B	B	NNP
1077	1084	binding	binding	NN
1085	1090	sites	site	NNS
1091	1093	of	of	IN
1094	1097	the	the	DT
1098	1104	VCAM-1	vcam-1	NN
1105	1109	gene	gene	NN
1110	1111	(	(	(
1111	1124	VCAM-NF-kappa	VCAM-NF-kappa	NNP
1125	1126	B	B	NNP
1126	1127	)	)	)
1127	1128	,	,	,
1129	1132	the	the	DT
1133	1144	antioxidant	antioxidant	NN
1145	1148	had	have	VBD
1149	1151	no	no	DT
1152	1163	appreciable	appreciable	JJ
1164	1170	effect	effect	NN
1171	1175	when	when	WRB
1176	1178	an	an	DT
1179	1187	oligomer	oligomer	NN
1188	1201	corresponding	correspond	VBG
1202	1204	to	to	TO
1205	1208	the	the	DT
1209	1218	consensus	consensus	NN
1219	1227	NF-kappa	NF-kappa	NNP
1228	1229	B	B	NNP
1230	1237	binding	binding	NN
1238	1242	site	site	NN
1243	1245	of	of	IN
1246	1249	the	the	DT
1250	1260	E-selectin	E-selectin	NNP
1261	1265	gene	gene	NN
1266	1267	(	(	(
1267	1286	E-selectin-NF-kappa	E-selectin-NF-kappa	NNP
1287	1288	B	B	NNP
1288	1289	)	)	)
1290	1293	was	be	VBD
1294	1298	used	use	VBN
1298	1299	.	.	.

1300	1307	Because	because	IN
1308	1316	NF-kappa	NF-kappa	NNP
1317	1318	B	B	NNP
1319	1322	has	have	VBZ
1323	1327	been	be	VBN
1328	1336	reported	report	VBN
1337	1339	to	to	TO
1340	1342	be	be	VB
1343	1348	redox	redox	NN
1349	1358	sensitive	sensitive	JJ
1358	1359	,	,	,
1360	1362	we	we	PRP
1363	1370	studied	study	VBD
1371	1374	the	the	DT
1375	1382	effects	effect	NNS
1383	1385	of	of	IN
1386	1389	NAC	NAC	NNP
1390	1392	on	on	IN
1393	1396	the	the	DT
1397	1399	EC	EC	NNP
1400	1405	redox	redox	NN
1406	1417	environment	environment	NN
1417	1418	.	.	.

1419	1422	NAC	NAC	NNP
1423	1429	caused	cause	VBD
1430	1432	an	an	DT
1433	1441	expected	expect	VBN
1442	1450	dramatic	dramatic	JJ
1451	1459	increase	increase	NN
1460	1462	in	in	IN
1463	1466	the	the	DT
1467	1474	reduced	reduce	VBN
1475	1486	glutathione	glutathione	NN
1487	1488	(	(	(
1488	1491	GSH	GSH	NNP
1491	1492	)	)	)
1493	1499	levels	level	NNS
1500	1502	in	in	IN
1503	1505	EC	EC	NNP
1505	1506	.	.	.

1507	1509	In	in	FW
1510	1515	vitro	vitro	FW
1516	1523	studies	study	NNS
1524	1536	demonstrated	demonstrate	VBD
1537	1541	that	that	IN
1542	1549	whereas	whereas	IN
1550	1553	the	the	DT
1554	1561	binding	binding	NN
1562	1570	affinity	affinity	NN
1571	1573	of	of	IN
1574	1582	NF-kappa	NF-kappa	NNP
1583	1584	B	B	NNP
1585	1587	to	to	TO
1588	1591	the	the	DT
1592	1605	VCAM-NF-kappa	VCAM-NF-kappa	NNP
1606	1607	B	B	NNP
1608	1616	oligomer	oligomer	NN
1617	1623	peaked	peak	VBD
1624	1626	at	at	IN
1627	1628	a	a	DT
1629	1644	GSH-to-oxidized	gsh-to-oxidized	JJ
1645	1656	glutathione	glutathione	NN
1657	1658	(	(	(
1658	1662	GSSG	GSSG	NNP
1662	1663	)	)	)
1664	1669	ratio	ratio	NN
1670	1672	of	of	IN
1673	1686	approximately	approximately	RB
1687	1690	200	200	CD
1691	1694	and	and	CC
1695	1704	decreased	decrease	VBD
1705	1707	at	at	IN
1708	1714	higher	high	JJR
1715	1721	ratios	ratio	NNS
1721	1722	,	,	,
1723	1726	the	the	DT
1727	1734	binding	binding	NN
1735	1737	to	to	TO
1738	1741	the	the	DT
1742	1761	E-selectin-NF-kappa	E-selectin-NF-kappa	NNP
1762	1763	B	B	NNP
1764	1772	oligomer	oligomer	NN
1773	1781	appeared	appear	VBD
1782	1792	relatively	relatively	RB
1793	1803	unaffected	unaffected	JJ
1804	1808	even	even	RB
1809	1811	at	at	IN
1812	1818	ratios	ratio	NNS
1819	1820	>	>	SYM
1821	1824	400	400	CD
1824	1825	,	,	,
1826	1830	i.e.	i.e.	FW
1830	1831	,	,	,
1832	1837	those	those	DT
1838	1846	achieved	achieve	VBN
1847	1849	in	in	IN
1850	1852	EC	EC	NNP
1853	1860	treated	treat	VBN
1861	1865	with	with	IN
1866	1868	40	40	CD
1869	1871	mM	mM	NNP
1872	1875	NAC	NAC	NNP
1875	1876	.	.	.

1877	1882	These	these	DT
1883	1890	results	result	NNS
1891	1898	suggest	suggest	VBP
1899	1903	that	that	IN
1904	1912	NF-kappa	NF-kappa	NNP
1913	1914	B	B	NNP
1915	1922	binding	bind	VBG
1923	1925	to	to	TO
1926	1929	its	its	PRP$
1930	1939	consensus	consensus	NN
1940	1949	sequences	sequence	NNS
1950	1952	in	in	IN
1953	1956	the	the	DT
1957	1963	VCAM-1	VCAM-1	NNP
1964	1967	and	and	CC
1968	1978	E-selectin	E-selectin	NNP
1979	1983	gene	gene	NN
1984	1992	exhibits	exhibit	VBZ
1993	1999	marked	marked	JJ
2000	2011	differences	difference	NNS
2012	2014	in	in	IN
2015	2020	redox	redox	NN
2021	2032	sensitivity	sensitivity	NN
2032	2033	,	,	,
2034	2042	allowing	allow	VBG
2043	2046	for	for	IN
2047	2059	differential	differential	JJ
2060	2064	gene	gene	NN
2065	2075	expression	expression	NN
2076	2085	regulated	regulate	VBN
2086	2088	by	by	IN
2089	2092	the	the	DT
2093	2097	same	same	JJ
2098	2111	transcription	transcription	NN
2112	2118	factor	factor	NN
2118	2119	.	.	.

2120	2123	Our	our	PRP$
2124	2128	data	datum	NNS
2129	2133	also	also	RB
2134	2145	demonstrate	demonstrate	VBP
2146	2150	that	that	IN
2151	2154	NAC	NAC	NNP
2155	2164	increases	increase	VBZ
2165	2168	the	the	DT
2169	2180	GSH-to-GSSG	GSH-to-GSSG	NNP
2181	2186	ratio	ratio	NN
2187	2193	within	within	IN
2194	2197	the	the	DT
2198	2200	EC	EC	NNP
2201	2211	suggesting	suggest	VBG
2212	2215	one	one	CD
2216	2224	possible	possible	JJ
2225	2234	mechanism	mechanism	NN
2235	2242	through	through	IN
2243	2248	which	which	WDT
2249	2253	this	this	DT
2254	2265	antioxidant	antioxidant	NN
2266	2274	inhibits	inhibit	VBZ
2275	2290	agonist-induced	agonist-induced	JJ
2291	2299	monocyte	monocyte	NN
2300	2308	adhesion	adhesion	NN
2309	2311	to	to	TO
2312	2314	EC	EC	NNP
2314	2315	.	.	.