0 15 Transcriptional transcriptional JJ 16 26 regulation regulation NN 27 33 during during IN 34 46 myelopoiesis myelopoiesis NN 46 47 . . . 49 52 The the DT 53 64 coordinated coordinate VBN 65 75 production production NN 76 78 of of IN 79 82 all all DT 83 88 blood blood NN 89 94 cells cell NNS 95 99 from from IN 100 101 a a DT 102 108 common common JJ 109 113 stem stem NN 114 118 cell cell NN 119 121 is be VBZ 122 123 a a DT 124 130 highly highly RB 131 140 regulated regulate VBN 141 148 process process NN 149 158 involving involve VBG 159 169 successive successive JJ 170 176 stages stage NNS 177 179 of of IN 180 190 commitment commitment NN 191 194 and and CC 195 210 differentiation differentiation NN 210 211 . . . 212 216 From from IN 217 225 analyses analysis NNS 226 228 of of IN 229 233 mice mouse NNS 234 243 deficient deficient JJ 244 246 in in IN 247 260 transcription transcription NN 261 267 factor factor NN 268 273 genes gene NNS 274 277 and and CC 278 282 from from IN 283 286 the the DT 287 304 characterizations characterization NNS 305 307 of of IN 308 318 chromosome chromosome NN 319 330 breakpoints breakpoint NNS 331 333 in in IN 334 339 human human JJ 340 349 leukemias leukemia NNS 349 350 , , , 351 353 it it PRP 354 357 has have VBZ 358 364 become become VBN 365 372 evident evident JJ 373 377 that that IN 378 391 transcription transcription NN 392 399 factors factor NNS 400 403 are be VBP 404 413 important important JJ 414 424 regulators regulator NNS 425 427 of of IN 428 441 hematopoiesis hematopoiesis NN 441 442 . . . 443 449 During during IN 450 462 myelopoiesis myelopoiesis NN 462 463 , , , 464 469 which which WDT 470 478 includes include VBZ 479 482 the the DT 483 494 development development NN 495 497 of of IN 498 510 granulocytic granulocytic JJ 511 514 and and CC 515 524 monocytic monocytic JJ 525 533 lineages lineage NNS 533 534 , , , 535 548 transcription transcription NN 549 556 factors factor NNS 557 561 from from IN 562 569 several several JJ 570 578 families family NNS 579 582 are be VBP 583 589 active active JJ 589 590 , , , 591 600 including include VBG 601 609 AML1/CBF AML1/CBF NNP 610 614 beta beta NN 614 615 , , , 616 621 C/EBP C/EBP NNP 621 622 , , , 623 626 Ets Ets NNP 626 627 , , , 628 633 c-Myb c-myb NN 633 634 , , , 635 638 HOX HOX NNP 638 639 , , , 640 643 and and CC 644 649 MZF-1 MZF-1 NNP 649 650 . . . 651 654 Few few JJ 655 657 of of IN 658 663 these these DT 664 671 factors factor NNS 672 675 are be VBP 676 685 expressed express VBN 686 697 exclusively exclusively RB 698 700 in in IN 701 708 myeloid myeloid JJ 709 714 cells cell NNS 714 715 ; ; : 716 723 instead instead RB 724 726 it it PRP 727 734 appears appear VBZ 735 739 that that IN 740 744 they they PRP 745 758 cooperatively cooperatively RB 759 767 regulate regulate VBP 768 781 transcription transcription NN 782 784 of of IN 785 801 myeloid-specific myeloid-specific JJ 802 807 genes gene NNS 807 808 . . . 809 813 Here here RB 814 816 we we PRP 817 824 discuss discuss VBP 825 831 recent recent JJ 832 840 advances advance NNS 841 843 in in IN 844 859 transcriptional transcriptional JJ 860 870 regulation regulation NN 871 877 during during IN 878 890 myelopoiesis myelopoiesis NN 890 891 . . .