0 12 Rel/NF-kappa Rel/NF-kappa NNP 13 14 B B NNP 15 28 transcription transcription NN 29 36 factors factor NNS 37 40 and and CC 41 44 the the DT 45 52 control control NN 53 55 of of IN 56 65 apoptosis apoptosis NN 65 66 . . . 68 71 The the DT 72 79 process process NN 80 82 of of IN 83 92 apoptosis apoptosis NN 93 95 is be VBZ 96 100 used use VBN 101 103 to to TO 104 113 eliminate eliminate VB 114 122 unwanted unwanted JJ 123 128 cells cell NNS 129 133 from from IN 134 135 a a DT 136 140 wide wide JJ 141 148 variety variety NN 149 151 of of IN 152 161 organisms organism NNS 161 162 . . . 163 170 Various various JJ 171 184 extracellular extracellular JJ 185 192 signals signal NNS 192 193 , , , 194 199 often often RB 200 210 converging converge VBG 211 213 in in IN 214 220 common common JJ 221 234 intracellular intracellular JJ 235 243 pathways pathway NNS 243 244 , , , 245 248 can can MD 249 255 induce induce VB 256 265 apoptosis apoptosis NN 266 268 in in IN 269 270 a a DT 271 289 cell-type-specific cell-type-specific JJ 290 297 fashion fashion NN 297 298 . . . 299 305 Recent recent JJ 306 310 work work NN 311 315 from from IN 316 323 several several JJ 324 336 laboratories laboratory NNS 337 340 has have VBZ 341 353 demonstrated demonstrate VBN 354 358 that that IN 359 371 Rel/NF-kappa Rel/NF-kappa NNP 372 373 B B NNP 374 387 transcription transcription NN 388 395 factors factor NNS 396 404 regulate regulate VBP 405 414 apoptosis apoptosis NN 415 417 in in IN 418 422 many many JJ 423 427 cell cell NN 428 433 types type NNS 433 434 . . . 435 437 In in IN 438 442 most most JJS 443 448 cells cell NNS 448 449 , , , 450 462 Rel/NF-kappa Rel/NF-kappa NNP 463 464 B B NNP 465 478 transcription transcription NN 479 486 factors factor NNS 487 493 appear appear VBP 494 496 to to TO 497 504 mediate mediate VB 505 513 survival survival NN 514 521 signals signal NNS 522 526 that that WDT 527 534 protect protect VBP 535 540 cells cell NNS 541 545 from from IN 546 555 apoptosis apoptosis NN 555 556 ; ; : 557 564 however however RB 564 565 , , , 566 571 under under IN 572 576 some some DT 577 590 circumstances circumstance NNS 590 591 , , , 592 602 activation activation NN 603 605 of of IN 606 611 these these DT 612 619 factors factor NNS 620 623 may may MD 624 628 also also RB 629 636 promote promote VB 637 646 apoptosis apoptosis NN 646 647 . . .