0 3 The the DT 4 8 role role NN 9 11 of of IN 12 24 Rel/NF-kappa Rel/NF-kappa NNP 25 26 B B NNP 27 35 proteins protein NNS 36 38 in in IN 39 44 viral viral JJ 45 56 oncogenesis oncogenesis NN 57 60 and and CC 61 64 the the DT 65 75 regulation regulation NN 76 78 of of IN 79 84 viral viral JJ 85 98 transcription transcription NN 98 99 . . . 101 113 Rel/NF-kappa Rel/NF-kappa NNP 114 115 B B NNP 116 118 is be VBZ 119 120 a a DT 121 131 ubiquitous ubiquitous JJ 132 145 transcription transcription NN 146 152 factor factor NN 153 157 that that WDT 158 166 consists consist VBZ 167 169 of of IN 170 178 multiple multiple JJ 179 190 polypeptide polypeptide NN 191 199 subunits subunit NNS 199 200 , , , 201 204 and and CC 205 207 is be VBZ 208 215 subject subject JJ 216 218 to to TO 219 226 complex complex JJ 227 237 regulatory regulatory JJ 238 248 mechanisms mechanism NNS 249 253 that that WDT 254 261 involve involve VBP 262 277 protein-protein protein-protein JJ 278 290 interactions interaction NNS 290 291 , , , 292 307 phosphorylation phosphorylation NN 307 308 , , , 309 323 ubiquitination ubiquitination NN 323 324 , , , 325 336 proteolytic proteolytic JJ 337 348 degradation degradation NN 348 349 , , , 350 353 and and CC 354 371 nucleocytoplasmic nucleocytoplasmic JJ 372 385 translocation translocation NN 385 386 . . . 387 390 The the DT 391 404 sophisticated sophisticated JJ 405 412 control control NN 413 415 of of IN 416 428 Rel/NF-kappa Rel/NF-kappa NNP 429 430 B B NNP 431 439 activity activity NN 440 442 is be VBZ 443 446 not not RB 447 457 surprising surprising JJ 458 463 since since IN 464 468 this this DT 469 482 transcription transcription NN 483 489 factor factor NN 490 492 is be VBZ 493 501 involved involve VBN 502 504 in in IN 505 506 a a DT 507 511 wide wide JJ 512 517 array array NN 518 520 of of IN 521 529 cellular cellular JJ 530 539 responses response NNS 540 542 to to TO 543 556 extracellular extracellular JJ 557 561 cues cue NNS 561 562 , , , 563 573 associated associate VBN 574 578 with with IN 579 585 growth growth NN 585 586 , , , 587 598 development development NN 598 599 , , , 600 609 apoptosis apoptosis NN 609 610 , , , 611 614 and and CC 615 623 pathogen pathogen NN 624 632 invasion invasion NN 632 633 . . . 634 638 Thus thus RB 638 639 , , , 640 642 it it PRP 643 645 is be VBZ 646 649 not not RB 650 660 unexpected unexpected JJ 661 665 that that IN 666 670 this this DT 671 680 versatile versatile JJ 681 689 cellular cellular JJ 690 701 homeostatic homeostatic JJ 702 708 switch switch NN 709 714 would would MD 715 717 be be VB 718 726 affected affect VBN 727 729 by by IN 730 731 a a DT 732 739 variety variety NN 740 742 of of IN 743 748 viral viral JJ 749 758 pathogens pathogen NNS 758 759 , , , 760 765 which which WDT 766 770 have have VBP 771 778 evolved evolve VBN 779 789 mechanisms mechanism NNS 790 792 to to TO 793 800 utilize utilize VB 801 808 various various JJ 809 816 aspects aspect NNS 817 819 of of IN 820 832 Rel/NF-kappa Rel/NF-kappa NNP 833 834 B B NNP 835 843 activity activity NN 844 846 to to TO 847 857 facilitate facilitate VB 858 863 their their PRP$ 864 875 replication replication NN 875 876 , , , 877 881 cell cell NN 882 890 survival survival NN 891 894 and and CC 895 903 possibly possibly RB 904 911 evasion evasion NN 912 914 of of IN 915 921 immune immune JJ 922 931 responses response NNS 931 932 . . . 933 937 This this DT 938 944 review review NN 945 949 will will MD 950 955 cover cover VB 956 959 the the DT 960 969 molecular molecular JJ 970 980 mechanisms mechanism NNS 981 985 that that WDT 986 989 are be VBP 990 998 utilized utilize VBN 999 1001 by by IN 1002 1011 mammalian mammalian JJ 1012 1021 oncogenic oncogenic JJ 1022 1029 viruses virus NNS 1030 1032 to to TO 1033 1039 affect affect VB 1040 1043 the the DT 1044 1052 activity activity NN 1053 1055 of of IN 1056 1068 Rel/NF-kappa Rel/NF-kappa NNP 1069 1070 B B NNP 1071 1084 transcription transcription NN 1085 1092 factors factor NNS 1093 1096 and and CC 1097 1100 the the DT 1101 1105 role role NN 1106 1108 of of IN 1109 1121 Rel/NF-kappa Rel/NF-kappa NNP 1122 1123 B B NNP 1124 1126 in in IN 1127 1130 the the DT 1131 1141 regulation regulation NN 1142 1144 of of IN 1145 1150 viral viral JJ 1151 1155 gene gene NN 1156 1166 expression expression NN 1167 1170 and and CC 1171 1182 replication replication NN 1182 1183 . . .