0 10 Activation Activation NNP 11 13 of of IN 14 15 a a DT 16 21 novel novel JJ 22 26 gene gene NN 27 29 in in IN 30 34 3q21 3q21 NN 35 38 and and CC 39 53 identification identification NN 54 56 of of IN 57 67 intergenic intergenic JJ 68 74 fusion fusion NN 75 86 transcripts transcript NNS 87 91 with with IN 92 101 ecotropic ecotropic JJ 102 107 viral viral JJ 108 117 insertion insertion NN 118 122 site site NN 123 124 I i CD 125 127 in in IN 128 136 leukemia leukemia NN 136 137 . . . 139 141 We we PRP 142 146 have have VBP 147 157 identified identify VBN 158 159 a a DT 160 165 novel novel JJ 166 170 gene gene NN 170 171 , , , 172 175 GR6 GR6 NNP 175 176 , , , 177 184 located located JJ 185 191 within within IN 192 195 the the DT 196 204 leukemia leukemia NN 205 215 breakpoint breakpoint NN 216 222 region region NN 223 225 of of IN 226 230 3q21 3q21 NN 230 231 , , , 232 236 that that WDT 237 239 is be VBZ 240 248 normally normally RB 249 258 expressed express VBN 259 261 in in IN 262 267 early early JJ 268 273 fetal fetal JJ 274 285 development development NN 286 289 but but CC 290 293 not not RB 294 296 in in IN 297 302 adult adult JJ 303 313 peripheral peripheral JJ 314 319 blood blood NN 319 320 . . . 321 324 GR6 GR6 NNP 325 327 is be VBZ 328 337 activated activate VBN 338 340 in in IN 341 344 the the DT 345 354 UCSD-AML1 ucsd-aml1 NN 355 359 cell cell NN 360 364 line line NN 365 368 and and CC 369 371 in in IN 372 373 a a DT 374 382 leukemic leukemic JJ 383 389 sample sample NN 389 390 , , , 391 395 both both DT 396 398 of of IN 399 404 which which WDT 405 410 carry carry VBP 411 412 a a DT 413 428 t(3;3)(q21;q26) t(3;3)(q21;q26) NN 428 429 . . . 430 432 In in IN 433 442 UCSD-AML1 UCSD-AML1 NNP 442 443 , , , 444 446 we we PRP 447 451 have have VBP 452 456 also also RB 457 467 identified identify VBN 468 474 fusion fusion NN 475 486 transcripts transcript NNS 487 494 between between IN 495 498 the the DT 499 508 ecotropic ecotropic JJ 509 514 viral viral JJ 515 524 insertion insertion NN 525 529 site site NN 530 531 I i CD 532 533 ( ( ( 533 537 EVI1 EVI1 NNP 537 538 ) ) ) 539 543 gene gene NN 544 546 in in IN 547 551 3q26 3q26 NN 552 555 and and CC 556 559 GR6 GR6 NNP 560 563 and and CC 564 571 between between IN 572 576 EVI1 EVI1 NNP 577 580 and and CC 581 591 Ribophorin Ribophorin NNP 592 593 I i CD 594 598 that that WDT 599 603 maps map VBZ 604 606 30 30 CD 607 609 kb kb NN 610 619 telomeric telomeric JJ 620 622 to to TO 623 626 GR6 GR6 NNP 627 629 in in IN 630 634 3q21 3q21 NN 634 635 . . . 636 639 All all DT 640 647 fusions fusion NNS 648 654 splice splice VBP 655 658 the the DT 659 660 5 5 CD 660 661 ’ ' SYM 662 666 ends end NNS 667 669 of of IN 670 673 the the DT 674 678 3q21 3q21 NN 679 684 genes gene NNS 685 689 into into IN 690 694 exon exon NN 695 696 2 2 CD 697 699 of of IN 700 703 the the DT 704 708 EVI1 evi1 NN 709 713 gene gene NN 713 714 , , , 715 717 an an DT 718 723 event event NN 724 728 that that WDT 729 731 is be VBZ 732 739 similar similar JJ 740 742 to to TO 743 746 the the DT 747 753 normal normal JJ 754 764 intergenic intergenic JJ 765 773 splicing splicing NN 774 776 of of IN 777 786 MDS1-EVI1 MDS1-EVI1 NNP 787 790 and and CC 791 793 to to TO 794 799 those those DT 800 810 previously previously RB 811 821 documented document VBN 822 824 in in IN 825 834 leukemias leukemia NNS 835 839 with with IN 840 847 t(3;21) t(3;21) NNP 848 851 and and CC 852 859 t(3;12) t(3;12) NNP 859 860 , , , 861 863 in in IN 864 869 which which WDT 870 875 acute acute JJ 876 887 myelogenous myelogenous JJ 888 896 leukemia leukemia NN 897 903 1-EVI1 1-evi1 NN 904 911 fusions fusion NNS 912 915 and and CC 916 925 ETV6-EVI1 etv6-evi1 NN 926 933 fusions fusion NNS 933 934 , , , 935 947 respectively respectively RB 947 948 , , , 949 954 occur occur VBP 954 955 . . . 956 959 The the DT 960 970 Ribophorin Ribophorin NNP 971 977 I-EVI1 i-evi1 NN 978 984 fusion fusion NN 985 987 in in IN 988 998 particular particular JJ 999 1002 may may MD 1003 1005 be be VB 1006 1007 a a DT 1008 1014 common common JJ 1015 1025 occurrence occurrence NN 1026 1028 in in IN 1029 1035 t(3;3) t(3;3) NNP 1035 1036 . . .