0 5 NF-AT NF-AT NNP 6 16 activation activation NN 17 24 induced induce VBN 25 27 by by IN 28 29 a a DT 30 46 CAML-interacting caml-interacting JJ 47 53 member member NN 54 56 of of IN 57 60 the the DT 61 66 tumor tumor NN 67 75 necrosis necrosis NN 76 82 factor factor NN 83 91 receptor receptor NN 92 103 superfamily superfamily NN 103 104 . . . 106 116 Activation Activation NNP 117 119 of of IN 120 123 the the DT 124 131 nuclear nuclear JJ 132 138 factor factor NN 139 141 of of IN 142 151 activated activate VBN 152 153 T t NN 154 159 cells cell NNS 160 173 transcription transcription NN 174 180 factor factor NN 181 182 ( ( ( 182 187 NF-AT NF-AT NNP 187 188 ) ) ) 189 191 is be VBZ 192 193 a a DT 194 197 key key JJ 198 203 event event NN 204 214 underlying underlie VBG 215 225 lymphocyte lymphocyte NN 226 232 action action NN 232 233 . . . 234 237 The the DT 238 242 CAML CAML NNP 243 244 ( ( ( 244 261 calcium-modulator calcium-modulator NN 262 265 and and CC 266 277 cyclophilin cyclophilin NN 278 284 ligand ligand NN 284 285 ) ) ) 286 293 protein protein NN 294 296 is be VBZ 297 298 a a DT 299 308 coinducer coinducer NN 309 311 of of IN 312 317 NF-AT NF-AT NNP 318 328 activation activation NN 329 333 when when WRB 334 347 overexpressed overexpresse VBN 348 350 in in IN 351 357 Jurkat Jurkat NNP 358 359 T t NN 360 365 cells cell NNS 365 366 . . . 367 368 A a DT 369 375 member member NN 376 378 of of IN 379 382 the the DT 383 388 tumor tumor NN 389 397 necrosis necrosis NN 398 404 factor factor NN 405 413 receptor receptor NN 414 425 superfamily superfamily NN 426 429 was be VBD 430 438 isolated isolate VBN 439 441 by by IN 442 448 virtue virtue NN 449 451 of of IN 452 455 its its PRP$ 456 464 affinity affinity NN 465 468 for for IN 469 473 CAML CAML NNP 473 474 . . . 475 488 Cross-linking cross-linking NN 489 491 of of IN 492 496 this this DT 497 516 lymphocyte-specific lymphocyte-specific JJ 517 524 protein protein NN 524 525 , , , 526 536 designated designate VBN 537 541 TACI TACI NNP 542 543 ( ( ( 543 556 transmembrane transmembrane JJ 557 566 activator activator NN 567 570 and and CC 571 586 CAML-interactor CAML-interactor NNP 586 587 ) ) ) 587 588 , , , 589 591 on on IN 592 595 the the DT 596 603 surface surface NN 604 606 of of IN 607 618 transfected transfecte VBN 619 625 Jurkat Jurkat NNP 626 631 cells cell NNS 632 636 with with IN 637 650 TACI-specific taci-specific JJ 651 661 antibodies antibody NNS 662 665 led lead VBD 666 668 to to TO 669 679 activation activation NN 680 682 of of IN 683 686 the the DT 687 700 transcription transcription NN 701 708 factors factor NNS 709 714 NF-AT NF-AT NNP 714 715 , , , 716 720 AP-1 ap-1 NN 720 721 , , , 722 725 and and CC 726 734 NFkappaB NFkappaB NNP 734 735 . . . 736 748 TACI-induced taci-induced JJ 749 759 activation activation NN 760 762 of of IN 763 768 NF-AT NF-AT NNP 769 772 was be VBD 773 785 specifically specifically RB 786 793 blocked block VBN 794 796 by by IN 797 798 a a DT 799 816 dominant-negative dominant-negative JJ 817 821 CAML caml NN 822 828 mutant mutant NN 828 829 , , , 830 834 thus thus RB 835 846 implicating implicate VBG 847 851 CAML CAML NNP 852 854 as as IN 855 856 a a DT 857 866 signaling signaling NN 867 879 intermediate intermediate NN 879 880 . . .