0	13	Interleukin-7	Interleukin-7	NNP
14	25	upregulates	upregulate	VBZ
26	29	the	the	DT
30	48	interleukin-2-gene	interleukin-2-gene	JJ
49	59	expression	expression	NN
60	62	in	in	IN
63	72	activated	activate	VBN
73	78	human	human	JJ
79	80	T	t	NN
81	92	lymphocytes	lymphocyte	NNS
93	95	at	at	IN
96	99	the	the	DT
100	115	transcriptional	transcriptional	JJ
116	121	level	level	NN
122	124	by	by	IN
125	134	enhancing	enhance	VBG
135	138	the	the	DT
139	142	DNA	dna	NN
143	150	binding	binding	NN
151	161	activities	activity	NNS
162	164	of	of	IN
165	169	both	both	CC
170	177	nuclear	nuclear	JJ
178	184	factor	factor	NN
185	187	of	of	IN
188	197	activated	activate	VBN
198	199	T	t	NN
200	205	cells	cell	NNS
206	209	and	and	CC
210	219	activator	activator	NN
220	229	protein-1	protein-1	NN
229	230	.	.	.

232	234	In	in	IN
235	238	the	the	DT
239	246	present	present	JJ
247	253	report	report	NN
253	254	,	,	,
255	257	we	we	PRP
258	265	studied	study	VBD
266	269	the	the	DT
270	274	role	role	NN
275	277	of	of	IN
278	281	the	the	DT
282	297	stromal-derived	stromal-derived	JJ
298	306	cytokine	cytokine	NN
307	320	interleukin-7	interleukin-7	NN
321	322	(	(	(
322	326	IL-7	il-7	NN
326	327	)	)	)
328	330	in	in	IN
331	334	the	the	DT
335	344	IL-2-gene	il-2-gene	JJ
345	355	regulation	regulation	NN
356	358	in	in	IN
359	368	activated	activate	VBN
369	370	T	t	NN
371	382	lymphocytes	lymphocyte	NNS
382	383	.	.	.

384	394	Production	production	NN
395	397	of	of	IN
398	402	IL-2	il-2	NN
403	411	requires	require	VBZ
412	415	the	the	DT
416	425	formation	formation	NN
426	428	of	of	IN
429	442	transcription	transcription	NN
443	450	factors	factor	NNS
451	459	involved	involve	VBN
460	462	in	in	IN
463	466	the	the	DT
467	476	IL-2-gene	il-2-gene	JJ
477	487	regulation	regulation	NN
487	488	.	.	.

489	495	T-cell	t-cell	NN
496	504	receptor	receptor	NN
505	506	(	(	(
506	514	TCR)/CD3	tcr)/cd3	NN
515	525	engagement	engagement	NN
526	533	results	result	VBZ
534	536	in	in	IN
537	540	the	the	DT
541	551	activation	activation	NN
552	554	of	of	IN
555	562	nuclear	nuclear	JJ
563	569	factor	factor	NN
570	572	of	of	IN
573	582	activated	activate	VBN
583	584	T	t	NN
585	590	cells	cell	NNS
591	592	(	(	(
592	596	NFAT	NFAT	NNP
596	597	)	)	)
597	598	,	,	,
599	608	activator	activator	NN
609	618	protein-1	protein-1	NN
619	620	(	(	(
620	624	AP-1	ap-1	NN
624	625	)	)	)
625	626	,	,	,
627	630	and	and	CC
631	638	nuclear	nuclear	JJ
639	645	factor	factor	NN
646	652	kappaB	kappaB	NNP
653	654	(	(	(
654	662	NFkappaB	NFkappaB	NNP
662	663	)	)	)
663	664	,	,	,
665	672	whereas	whereas	IN
673	676	the	the	DT
677	681	CD28	cd28	NN
682	692	responsive	responsive	JJ
693	700	complex	complex	NN
701	702	(	(	(
702	708	CD28RC	CD28RC	NNP
708	709	)	)	)
710	712	is	be	VBZ
713	722	activated	activate	VBN
723	725	in	in	IN
726	734	response	response	NN
735	737	to	to	TO
738	741	the	the	DT
742	746	CD28	cd28	NN
747	753	signal	signal	NN
753	754	.	.	.

755	768	Costimulation	costimulation	NN
769	771	of	of	IN
772	800	phytohemagglutinin/anti-CD28	phytohemagglutinin/anti-cd28	NN
801	810	activated	activate	VBN
811	812	T	t	NN
813	824	lymphocytes	lymphocyte	NNS
825	829	with	with	IN
830	834	IL-7	IL-7	NNP
835	842	induces	induce	VBZ
843	844	a	a	DT
845	853	fivefold	fivefold	RB
854	862	enhanced	enhance	VBN
863	872	IL-2-mRNA	IL-2-mRNA	NNP
873	885	accumulation	accumulation	NN
886	889	and	and	CC
890	891	a	a	DT
892	900	2.5-fold	2.5-fold	RB
901	909	enhanced	enhance	VBN
910	917	protein	protein	NN
918	927	secretion	secretion	NN
927	928	.	.	.

929	932	The	the	DT
933	942	IL-2-gene	il-2-gene	JJ
943	956	transcription	transcription	NN
957	961	rate	rate	NN
962	964	is	be	VBZ
965	974	increased	increase	VBN
975	983	3.4-fold	3.4-fold	RB
983	984	,	,	,
985	995	indicating	indicate	VBG
996	1000	that	that	IN
1001	1004	the	the	DT
1005	1011	effect	effect	NN
1012	1014	of	of	IN
1015	1019	IL-7	IL-7	NNP
1020	1022	is	be	VBZ
1023	1025	in	in	IN
1026	1030	part	part	NN
1031	1039	mediated	mediate	VBN
1040	1042	at	at	IN
1043	1046	the	the	DT
1047	1062	transcriptional	transcriptional	JJ
1063	1068	level	level	NN
1068	1069	.	.	.

1070	1073	The	the	DT
1074	1083	molecular	molecular	JJ
1084	1094	mechanisms	mechanism	NNS
1095	1105	underlying	underlie	VBG
1106	1109	the	the	DT
1110	1114	IL-7	il-7	NN
1115	1121	effect	effect	NN
1122	1129	involve	involve	VBP
1130	1133	the	the	DT
1134	1146	upregulation	upregulation	NN
1147	1149	of	of	IN
1150	1153	the	the	DT
1154	1157	DNA	dna	NN
1158	1165	binding	binding	NN
1166	1174	activity	activity	NN
1175	1177	of	of	IN
1178	1182	NFAT	NFAT	NNP
1183	1184	(	(	(
1184	1186	60	60	CD
1186	1187	%	%	NN
1187	1188	)	)	)
1189	1192	and	and	CC
1193	1197	AP-1	ap-1	NN
1198	1199	(	(	(
1199	1202	120	120	CD
1202	1203	%	%	NN
1203	1204	)	)	)
1204	1205	,	,	,
1206	1213	without	without	IN
1214	1223	affecting	affect	VBG
1224	1227	the	the	DT
1228	1238	activities	activity	NNS
1239	1241	of	of	IN
1242	1250	NFkappaB	NFkappaB	NNP
1251	1254	and	and	CC
1255	1261	CD28RC	CD28RC	NNP
1261	1262	,	,	,
1263	1268	which	which	WDT
1269	1272	was	be	VBD
1273	1282	confirmed	confirm	VBN
1283	1285	by	by	IN
1286	1298	transfection	transfection	NN
1299	1305	assays	assay	NNS
1305	1306	.	.	.

1307	1309	We	we	PRP
1310	1314	also	also	RB
1315	1319	show	show	VBP
1320	1324	that	that	IN
1325	1328	the	the	DT
1329	1341	IL-7-induced	il-7-induced	JJ
1342	1353	enhancement	enhancement	NN
1354	1356	of	of	IN
1357	1360	the	the	DT
1361	1369	AP-1-DNA	AP-1-DNA	NNP
1370	1377	binding	binding	NN
1378	1386	activity	activity	NN
1387	1389	is	be	VBZ
1390	1393	not	not	RB
1394	1405	cyclosporin	cyclosporin	NN
1406	1417	A-sensitive	a-sensitive	JJ
1417	1418	.	.	.

1419	1424	Since	since	IN
1425	1429	AP-1	ap-1	NN
1430	1432	is	be	VBZ
1433	1437	part	part	NN
1438	1440	of	of	IN
1441	1444	the	the	DT
1445	1449	NFAT	NFAT	NNP
1450	1457	complex	complex	NN
1457	1458	,	,	,
1459	1461	we	we	PRP
1462	1470	conclude	conclude	VBP
1471	1475	that	that	IN
1476	1479	the	the	DT
1480	1494	IL-7-signaling	il-7-signaling	JJ
1495	1502	pathway	pathway	NN
1503	1505	is	be	VBZ
1506	1514	involved	involve	VBN
1515	1517	in	in	IN
1518	1521	the	the	DT
1522	1532	activation	activation	NN
1533	1535	of	of	IN
1536	1539	the	the	DT
1540	1543	fos	fos	NN
1544	1547	and	and	CC
1548	1551	jun	jun	NN
1552	1560	proteins	protein	NNS
1561	1563	of	of	IN
1564	1569	which	which	WDT
1570	1574	AP-1	ap-1	NN
1575	1583	consists	consist	VBZ
1583	1584	.	.	.