0 14 Monochloramine Monochloramine NNP 15 23 inhibits inhibit VBZ 24 31 phorbol phorbol NN 32 47 ester-inducible ester-inducible JJ 48 58 neutrophil neutrophil NN 59 70 respiratory respiratory JJ 71 76 burst burst NN 77 87 activation activation NN 88 91 and and CC 92 93 T t NN 94 98 cell cell NN 99 112 interleukin-2 interleukin-2 NN 113 121 receptor receptor NN 122 132 expression expression NN 133 135 by by IN 136 146 inhibiting inhibit VBG 147 156 inducible inducible JJ 157 164 protein protein NN 165 171 kinase kinase NNP 172 173 C C NNP 174 182 activity activity NN 182 183 . . . 185 199 Monochloramine Monochloramine NNP 200 211 derivatives derivative NNS 212 215 are be VBP 216 220 long long JJ 221 226 lived lived JJ 227 240 physiological physiological JJ 241 249 oxidants oxidant NNS 250 258 produced produce VBN 259 261 by by IN 262 273 neutrophils neutrophil NNS 274 280 during during IN 281 284 the the DT 285 296 respiratory respiratory JJ 297 302 burst burst NN 302 303 . . . 304 307 The the DT 308 315 effects effect NNS 316 318 of of IN 319 329 chemically chemically RB 330 338 prepared prepare VBN 339 353 monochloramine monochloramine NN 354 355 ( ( ( 355 360 NH2Cl NH2Cl NNP 360 361 ) ) ) 362 364 on on IN 365 372 protein protein NN 373 379 kinase kinase NNP 380 381 C C NNP 382 383 ( ( ( 383 386 PKC PKC NNP 386 387 ) ) ) 388 391 and and CC 392 404 PKC-mediated pkc-mediated JJ 405 413 cellular cellular JJ 414 423 responses response NNS 424 428 were be VBD 429 436 studied study VBN 437 439 in in IN 440 448 elicited elicit VBN 449 452 rat rat NN 453 463 peritoneal peritoneal JJ 464 475 neutrophils neutrophil NNS 476 479 and and CC 480 485 human human JJ 486 492 Jurkat Jurkat NNP 493 494 T t NN 495 500 cells cell NNS 500 501 . . . 502 513 Neutrophils neutrophil NNS 514 524 pretreated pretreate VBN 525 529 with with IN 530 535 NH2Cl NH2Cl NNP 536 537 ( ( ( 537 542 30-50 30-50 CD 543 549 microM microM NNP 549 550 ) ) ) 551 557 showed show VBD 558 559 a a DT 560 566 marked marked JJ 567 575 decrease decrease NN 576 578 in in IN 579 582 the the DT 583 594 respiratory respiratory JJ 595 600 burst burst NN 601 609 activity activity NN 610 617 induced induce VBN 618 620 by by IN 621 628 phorbol phorbol NN 629 641 12-myristate 12-myristate NN 642 652 13-acetate 13-acetate NN 653 654 ( ( ( 654 657 PMA PMA NNP 657 658 ) ) ) 658 659 , , , 660 665 which which WDT 666 668 is be VBZ 669 670 a a DT 671 677 potent potent JJ 678 681 PKC PKC NNP 682 691 activator activator NN 691 692 . . . 693 698 These these DT 699 704 cells cell NNS 704 705 , , , 706 713 however however RB 713 714 , , , 715 719 were be VBD 720 726 viable viable JJ 727 730 and and CC 731 737 showed show VBD 738 739 a a DT 740 748 complete complete JJ 749 760 respiratory respiratory JJ 761 766 burst burst NN 767 771 upon upon IN 772 783 arachidonic arachidonic JJ 784 788 acid acid NN 789 800 stimulation stimulation NN 800 801 , , , 802 807 which which WDT 808 815 induces induce VBZ 816 819 the the DT 820 831 respiratory respiratory JJ 832 837 burst burst NN 838 840 by by IN 841 842 a a DT 843 858 PKC-independent pkc-independent JJ 859 868 mechanism mechanism NN 868 869 . . . 870 873 The the DT 874 887 NH2Cl-treated nh2cl-treated JJ 888 899 neutrophils neutrophil NNS 900 906 showed show VBD 907 908 a a DT 909 917 decrease decrease NN 918 920 in in IN 921 925 both both CC 926 929 PKC PKC NNP 930 938 activity activity NN 939 942 and and CC 943 954 PMA-induced pma-induced JJ 955 970 phosphorylation phosphorylation NN 971 973 of of IN 974 975 a a DT 976 982 47-kDa 47-kda JJ 983 990 protein protein NN 990 991 , , , 992 997 which which WDT 998 1009 corresponds correspond VBZ 1010 1012 to to TO 1013 1016 the the DT 1017 1026 cytosolic cytosolic JJ 1027 1033 factor factor NN 1034 1036 of of IN 1037 1042 NADPH NADPH NNP 1043 1050 oxidase oxidase NN 1050 1051 , , , 1052 1061 p47(phox) p47(phox) NNP 1061 1062 . . . 1063 1069 Jurkat Jurkat NNP 1070 1071 T t NN 1072 1077 cells cell NNS 1078 1088 pretreated pretreate VBN 1089 1093 with with IN 1094 1099 NH2Cl NH2Cl NNP 1100 1101 ( ( ( 1101 1106 20-70 20-70 CD 1107 1113 microM microM NNP 1113 1114 ) ) ) 1115 1121 showed show VBD 1122 1123 a a DT 1124 1132 decrease decrease NN 1133 1135 in in IN 1136 1139 the the DT 1140 1150 expression expression NN 1151 1153 of of IN 1154 1157 the the DT 1158 1171 interleukin-2 interleukin-2 NN 1172 1180 receptor receptor NN 1181 1186 alpha alpha NN 1187 1192 chain chain NN 1193 1202 following follow VBG 1203 1206 PMA PMA NNP 1207 1218 stimulation stimulation NN 1218 1219 . . . 1220 1224 This this DT 1225 1228 was be VBD 1229 1233 also also RB 1234 1245 accompanied accompany VBN 1246 1248 by by IN 1249 1250 a a DT 1251 1259 decrease decrease NN 1260 1262 in in IN 1263 1267 both both CC 1268 1271 PKC PKC NNP 1272 1280 activity activity NN 1281 1284 and and CC 1285 1292 nuclear nuclear JJ 1293 1306 transcription transcription NN 1307 1320 factor-kappaB factor-kappab NN 1321 1331 activation activation NN 1331 1332 , , , 1333 1337 also also RB 1338 1345 without without IN 1346 1350 loss loss NN 1351 1353 of of IN 1354 1358 cell cell NN 1359 1368 viability viability NN 1368 1369 . . . 1370 1375 These these DT 1376 1383 results result NNS 1384 1388 show show VBP 1389 1393 that that IN 1394 1399 NH2Cl NH2Cl NNP 1400 1408 inhibits inhibit VBZ 1409 1421 PKC-mediated pkc-mediated JJ 1422 1430 cellular cellular JJ 1431 1440 responses response NNS 1441 1448 through through IN 1449 1459 inhibition inhibition NN 1460 1462 of of IN 1463 1466 the the DT 1467 1476 inducible inducible JJ 1477 1480 PKC PKC NNP 1481 1489 activity activity NN 1489 1490 . . .