0 7 Nuclear nuclear JJ 8 20 accumulation accumulation NN 21 23 of of IN 24 29 NFAT4 nfat4 NN 30 37 opposed oppose VBN 38 40 by by IN 41 44 the the DT 45 48 JNK JNK NNP 49 55 signal signal NN 56 68 transduction transduction NN 69 76 pathway pathway NN 76 77 . . . 79 82 The the DT 83 90 nuclear nuclear JJ 91 97 factor factor NN 98 100 of of IN 101 110 activated activate VBN 111 112 T t NN 113 118 cells cell NNS 119 120 ( ( ( 120 124 NFAT NFAT NNP 124 125 ) ) ) 126 131 group group NN 132 134 of of IN 135 148 transcription transcription NN 149 156 factors factor NNS 157 159 is be VBZ 160 168 retained retain VBN 169 171 in in IN 172 175 the the DT 176 185 cytoplasm cytoplasm NN 186 188 of of IN 189 198 quiescent quiescent JJ 199 204 cells cell NNS 204 205 . . . 206 210 NFAT NFAT NNP 211 221 activation activation NN 222 224 is be VBZ 225 233 mediated mediate VBN 234 236 in in IN 237 241 part part NN 242 244 by by IN 245 252 induced induce VBN 253 260 nuclear nuclear JJ 261 267 import import NN 267 268 . . . 269 273 This this DT 274 281 process process NN 282 290 requires require VBZ 291 308 calcium-dependent calcium-dependent JJ 309 326 dephosphorylation dephosphorylation NN 327 329 of of IN 330 334 NFAT NFAT NNP 335 341 caused cause VBN 342 344 by by IN 345 348 the the DT 349 360 phosphatase phosphatase NN 361 372 calcineurin calcineurin NN 372 373 . . . 374 377 The the DT 378 383 c-Jun c-jun NN 384 398 amino-terminal amino-terminal JJ 399 405 kinase kinase NNP 406 407 ( ( ( 407 410 JNK JNK NNP 410 411 ) ) ) 412 426 phosphorylates phosphorylate VBZ 427 432 NFAT4 nfat4 NN 433 435 on on IN 436 439 two two CD 440 445 sites site NNS 445 446 . . . 447 457 Mutational mutational JJ 458 465 removal removal NN 466 468 of of IN 469 472 the the DT 473 476 JNK JNK NNP 477 492 phosphorylation phosphorylation NN 493 498 sites site NNS 499 505 caused cause VBD 506 518 constitutive constitutive JJ 519 526 nuclear nuclear JJ 527 539 localization localization NN 540 542 of of IN 543 548 NFAT4 nfat4 NN 548 549 . . . 550 552 In in IN 553 561 contrast contrast NN 561 562 , , , 563 566 JNK JNK NNP 567 577 activation activation NN 578 580 in in IN 581 603 calcineurin-stimulated calcineurin-stimulated JJ 604 609 cells cell NNS 610 616 caused cause VBD 617 624 nuclear nuclear JJ 625 634 exclusion exclusion NN 635 637 of of IN 638 643 NFAT4 nfat4 NN 643 644 . . . 645 650 These these DT 651 659 findings finding NNS 660 664 show show VBP 665 669 that that IN 670 673 the the DT 674 681 nuclear nuclear JJ 682 694 accumulation accumulation NN 695 697 of of IN 698 703 NFAT4 nfat4 NN 704 712 promoted promote VBN 713 715 by by IN 716 727 calcineurin calcineurin NN 728 730 is be VBZ 731 738 opposed oppose VBN 739 741 by by IN 742 745 the the DT 746 749 JNK JNK NNP 750 756 signal signal NN 757 769 transduction transduction NN 770 777 pathway pathway NN 777 778 . . .