0	20	Phosphatidylinositol	Phosphatidylinositol	NNP
21	29	3-kinase	3-kinase	NNP
30	37	couples	couple	VBZ
38	41	the	the	DT
42	55	interleukin-2	interleukin-2	NN
56	64	receptor	receptor	NN
65	67	to	to	TO
68	71	the	the	DT
72	76	cell	cell	NN
77	82	cycle	cycle	NN
83	92	regulator	regulator	NN
93	97	E2F.	E2F.	NNP
99	103	Cell	Cell	NNP
104	109	cycle	cycle	NN
110	121	progression	progression	NN
122	131	initiated	initiate	VBN
132	134	by	by	IN
135	148	interleukin-2	interleukin-2	NN
149	150	(	(	(
150	154	IL-2	il-2	NN
154	155	)	)	)
156	158	in	in	IN
159	160	T	t	NN
161	166	cells	cell	NNS
167	169	is	be	VBZ
170	178	critical	critical	JJ
179	182	for	for	IN
183	202	lymphoproliferation	lymphoproliferation	NN
203	206	and	and	CC
207	209	an	an	DT
210	216	immune	immune	JJ
217	225	response	response	NN
225	226	.	.	.

227	239	Phosphatidyl	Phosphatidyl	NNP
240	248	inositol	inositol	NN
249	257	3-kinase	3-kinase	NNP
258	259	(	(	(
259	263	PI3K	PI3K	NNP
263	264	)	)	)
265	267	is	be	VBZ
268	277	activated	activate	VBN
278	280	by	by	IN
281	285	IL-2	il-2	NN
285	286	.	.	.

287	294	However	however	RB
294	295	,	,	,
296	303	nuclear	nuclear	JJ
304	311	targets	target	NNS
312	315	for	for	IN
316	320	PI3K	PI3K	NNP
321	324	are	be	VBP
325	328	not	not	RB
329	334	known	know	VBN
334	335	.	.	.

336	340	Here	here	RB
341	343	we	we	PRP
344	352	identify	identify	VBP
353	356	the	the	DT
357	361	cell	cell	NN
362	367	cycle	cycle	NN
368	377	regulator	regulator	NN
378	381	E2F	e2f	NN
382	384	as	as	IN
385	387	an	an	DT
388	392	IL-2	il-2	NN
393	399	target	target	NN
400	402	in	in	IN
403	404	T	t	NN
405	416	lymphocytes	lymphocyte	NNS
417	420	and	and	CC
421	425	PI3K	pi3k	NN
426	428	as	as	IN
429	432	the	the	DT
433	441	critical	critical	JJ
442	451	signaling	signaling	NN
452	459	pathway	pathway	NN
459	460	.	.	.

461	463	We	we	PRP
464	473	eliminate	eliminate	VBP
474	478	both	both	CC
479	484	Stat5	stat5	NN
485	488	and	and	CC
489	496	Raf/MEK	Raf/MEK	NNP
497	505	pathways	pathway	NNS
506	510	from	from	IN
511	514	E2F	E2F	NNP
515	525	regulation	regulation	NN
525	526	.	.	.

527	534	Protein	protein	NN
535	541	kinase	kinase	NNP
542	543	B	B	NNP
544	545	(	(	(
545	548	PKB	PKB	NNP
548	549	)	)	)
550	552	is	be	VBZ
553	562	activated	activate	VBN
563	565	by	by	IN
566	570	IL-2	il-2	NN
571	574	via	via	IN
575	580	PI3K.	PI3K.	NNP
581	584	The	the	DT
585	595	expression	expression	NN
596	598	of	of	IN
599	601	an	an	DT
602	608	active	active	JJ
609	612	PKB	pkb	NN
613	615	is	be	VBZ
616	626	sufficient	sufficient	JJ
627	629	to	to	TO
630	636	induce	induce	VB
637	640	E2F	E2F	NNP
641	649	activity	activity	NN
649	650	.	.	.

651	661	Inhibition	Inhibition	NNP
662	664	of	of	IN
665	669	PI3K	PI3K	NNP
670	678	inhibits	inhibit	VBZ
679	694	phosphorylation	phosphorylation	NN
695	697	of	of	IN
698	700	Rb	Rb	NNP
700	701	,	,	,
702	711	induction	induction	NN
712	714	of	of	IN
715	721	cyclin	cyclin	NN
722	724	D3	d3	NN
724	725	,	,	,
726	729	and	and	CC
730	741	degradation	degradation	NN
742	744	of	of	IN
745	752	p27kip1	p27kip1	NN
752	753	.	.	.

754	759	These	these	DT
760	767	results	result	NNS
768	777	establish	establish	VBP
778	779	a	a	DT
780	787	crucial	crucial	JJ
788	805	PI3K/PKB-mediated	pi3k/pkb-mediated	JJ
806	810	link	link	NN
811	818	between	between	IN
819	822	the	the	DT
823	827	IL-2	il-2	NN
828	836	teceptor	teceptor	NN
837	840	and	and	CC
841	844	the	the	DT
845	849	cell	cell	NN
850	855	cycle	cycle	NN
856	865	machinery	machinery	NN
865	866	.	.	.