0	3	LPS	LPS	NNP
4	13	tolerance	tolerance	NN
14	16	in	in	IN
17	38	monocytes/macrophages	monocytes/macrophage	NNS
38	39	:	:	:
40	45	three	three	CD
46	47	3	3	CD
47	48	’	'	SYM
49	57	cytosins	cytosin	NNS
58	61	are	be	VBP
62	70	required	require	VBN
71	73	in	in	IN
74	77	the	the	DT
78	81	DNA	dna	NN
82	89	binding	binding	NN
90	95	motif	motif	NN
96	99	for	for	IN
100	109	detection	detection	NN
110	112	of	of	IN
113	124	upregulated	upregulate	VBN
125	133	NF-kappa	NF-kappa	NNP
134	135	B	B	NNP
136	139	p50	p50	NN
140	150	homodimers	homodimer	NNS
150	151	.	.	.

153	157	When	when	WRB
158	167	monocytes	monocyte	NNS
168	171	are	be	VBP
172	182	stimulated	stimulate	VBN
183	187	with	with	IN
188	191	LPS	LPS	NNP
192	193	(	(	(
193	211	lipopolysaccharide	lipopolysaccharide	NN
211	212	)	)	)
213	223	repeatedly	repeatedly	RB
224	228	then	then	RB
229	232	the	the	DT
233	242	initially	initially	RB
243	247	high	high	JJ
248	258	expression	expression	NN
259	261	of	of	IN
262	265	the	the	DT
266	269	TNF	TNF	NNP
270	271	(	(	(
271	276	tumor	tumor	NN
277	285	necrosis	necrosis	NN
286	292	factor	factor	NN
292	293	)	)	)
294	298	gene	gene	NN
299	301	is	be	VBZ
302	306	only	only	RB
307	311	very	very	RB
312	315	low	low	JJ
315	316	,	,	,
317	321	i.e.	i.e.	FW
322	325	the	the	DT
326	331	cells	cell	NNS
332	335	are	be	VBP
336	344	tolerant	tolerant	JJ
345	347	to	to	TO
348	351	LPS	lps	NN
351	352	.	.	.

353	361	Tolerant	tolerant	JJ
362	367	cells	cell	NNS
368	373	still	still	RB
374	381	express	express	VBP
382	385	the	the	DT
386	390	CD14	cd14	NN
391	399	receptor	receptor	NN
400	403	and	and	CC
404	408	they	they	PRP
409	412	can	can	MD
413	418	still	still	RB
419	421	be	be	VB
422	431	activated	activate	VBN
432	434	to	to	TO
435	443	mobilize	mobilize	VB
444	452	NF-kappa	NF-kappa	NNP
453	454	B	B	NNP
455	459	into	into	IN
460	467	nucleus	nucleus	NN
467	468	.	.	.

469	477	Analysis	Analysis	NNP
478	480	of	of	IN
481	484	the	the	DT
485	492	binding	binding	NN
493	501	proteins	protein	NNS
502	511	employing	employ	VBG
512	515	the	the	DT
516	520	-605	-605	CD
521	526	motif	motif	NN
527	529	of	of	IN
530	533	the	the	DT
534	539	human	human	JJ
540	543	TNF	tnf	NN
544	552	promoter	promoter	NN
553	554	(	(	(
554	565	GGGGCTGTCCC	GGGGCTGTCCC	NNP
565	566	)	)	)
567	575	revealed	reveal	VBD
576	580	that	that	IN
581	583	in	in	IN
584	592	tolerant	tolerant	JJ
593	598	cells	cell	NNS
599	601	of	of	IN
602	605	the	the	DT
606	611	human	human	JJ
612	621	monocytic	monocytic	JJ
622	626	cell	cell	NN
627	631	line	line	NN
632	636	Mono	Mono	NNP
637	640	Mac	Mac	NNP
641	642	6	6	CD
643	648	there	there	EX
649	651	is	be	VBZ
652	653	a	a	DT
654	666	predominance	predominance	NN
667	669	of	of	IN
670	676	p50p50	p50p50	NN
677	679	of	of	IN
680	688	NF-kappa	NF-kappa	NNP
689	691	B.	B.	NNP
692	694	We	we	PRP
695	698	now	now	RB
699	703	show	show	VBP
704	708	that	that	IN
709	710	a	a	DT
711	717	mutant	mutant	JJ
718	723	motif	motif	NN
724	728	that	that	WDT
729	738	exchanges	exchange	VBZ
739	742	the	the	DT
743	751	terminal	terminal	JJ
752	753	3	3	CD
753	754	’	'	SYM
755	756	C	C	NNP
757	760	for	for	IN
761	762	a	a	DT
763	764	G	G	NNP
765	770	fails	fail	VBZ
771	773	to	to	TO
774	778	bind	bind	VB
779	782	the	the	DT
783	786	p50	p50	NN
787	796	homodimer	homodimer	NN
797	801	that	that	WDT
802	804	is	be	VBZ
805	816	upregulated	upregulate	VBN
817	819	in	in	IN
820	823	LPS	LPS	NNP
824	829	toler	toler	NN
830	833	ant	ant	JJ
834	839	human	human	JJ
840	844	Mono	Mono	NNP
845	848	Mac	Mac	NNP
849	850	6	6	CD
851	856	cells	cell	NNS
856	857	.	.	.

858	861	The	the	DT
862	866	same	same	JJ
867	869	is	be	VBZ
870	874	true	true	JJ
875	878	for	for	IN
879	886	nuclear	nuclear	JJ
887	895	extracts	extract	NNS
896	901	taken	take	VBN
902	906	from	from	IN
907	910	the	the	DT
911	917	murine	murine	JJ
918	924	P388D1	p388d1	NN
925	935	macrophage	macrophage	NN
936	940	cell	cell	NN
941	945	line	line	NN
946	950	when	when	WRB
951	957	tested	test	VBN
958	962	with	with	IN
963	966	the	the	DT
967	971	-516	-516	CD
972	977	motif	motif	NN
978	980	of	of	IN
981	984	the	the	DT
985	991	murine	murine	JJ
992	995	TNF	tnf	NN
996	1004	promoter	promoter	NN
1005	1006	(	(	(
1006	1018	GGGGGCTTTCCC	GGGGGCTTTCCC	NNP
1018	1019	)	)	)
1019	1020	.	.	.

1021	1025	Here	here	RB
1026	1029	the	the	DT
1030	1034	wild	wild	JJ
1035	1039	type	type	NN
1040	1045	motif	motif	NN
1046	1051	gives	give	VBZ
1052	1061	efficient	efficient	JJ
1062	1069	binding	binding	NN
1070	1072	of	of	IN
1073	1079	p50p50	p50p50	NN
1080	1084	that	that	WDT
1085	1090	again	again	RB
1091	1093	is	be	VBZ
1094	1105	upregulated	upregulate	VBN
1106	1108	in	in	IN
1109	1117	tolerant	tolerant	JJ
1118	1123	cells	cell	NNS
1124	1131	whereas	whereas	IN
1132	1133	a	a	DT
1134	1140	mutant	mutant	NN
1141	1145	with	with	IN
1146	1147	a	a	DT
1148	1149	3	3	CD
1149	1150	’	'	SYM
1151	1152	G	G	NNP
1153	1158	shows	show	VBZ
1159	1165	hardly	hardly	RB
1166	1169	any	any	DT
1170	1177	binding	binding	NN
1178	1180	of	of	IN
1181	1187	p50p50	p50p50	NN
1187	1188	.	.	.

1189	1199	Conversely	conversely	RB
1199	1200	,	,	,
1201	1204	the	the	DT
1205	1211	murine	murine	JJ
1212	1217	kappa	kappa	NN
1218	1223	light	light	JJ
1224	1229	chain	chain	NN
1230	1238	enhancer	enhancer	NN
1239	1244	motif	motif	NN
1245	1246	(	(	(
1246	1258	GGGGACTTTCCG	GGGGACTTTCCG	NNP
1258	1259	)	)	)
1260	1264	does	do	VBZ
1265	1268	not	not	RB
1269	1280	efficiently	efficiently	RB
1281	1285	bind	bind	VB
1286	1289	the	the	DT
1290	1297	nuclear	nuclear	JJ
1298	1304	p50p50	p50p50	NN
1305	1309	from	from	IN
1310	1318	tolerant	tolerant	JJ
1319	1325	murine	murine	JJ
1326	1330	P388	p388	NN
1331	1342	macrophages	macrophage	NNS
1342	1343	.	.	.

1344	1351	Binding	binding	NN
1352	1354	is	be	VBZ
1354	1355	,	,	,
1356	1363	however	however	RB
1363	1364	,	,	,
1365	1372	readily	readily	RB
1373	1381	detected	detect	VBN
1382	1386	when	when	WRB
1387	1390	the	the	DT
1391	1392	3	3	CD
1392	1393	’	'	SYM
1394	1395	G	G	NNP
1396	1398	is	be	VBZ
1399	1407	replaced	replace	VBN
1408	1410	by	by	IN
1411	1412	a	a	DT
1413	1414	C	C	NNP
1414	1415	.	.	.

1416	1421	These	these	DT
1422	1426	data	datum	NNS
1427	1431	show	show	VBP
1432	1436	that	that	IN
1437	1440	the	the	DT
1441	1450	detection	detection	NN
1451	1453	of	of	IN
1454	1465	upregulated	upregulate	VBN
1466	1469	p50	p50	NN
1470	1480	homodimers	homodimer	NNS
1481	1483	in	in	IN
1484	1487	LPS	LPS	NNP
1488	1496	tolerant	tolerant	JJ
1497	1502	cells	cell	NNS
1503	1505	is	be	VBZ
1506	1515	dependent	dependent	JJ
1516	1518	on	on	IN
1519	1525	subtle	subtle	JJ
1526	1537	differences	difference	NNS
1538	1540	in	in	IN
1541	1544	the	the	DT
1545	1553	sequence	sequence	NN
1554	1556	of	of	IN
1557	1560	the	the	DT
1561	1564	DNA	DNA	NNP
1565	1572	binding	binding	NN
1573	1578	motif	motif	NN
1578	1579	.	.	.