0 10 Expression expression NN 11 13 of of IN 14 27 transcription transcription NN 28 34 factor factor NN 35 40 genes gene NNS 41 46 after after IN 47 56 influenza influenza NN 57 58 A a NN 59 64 virus virus NN 65 74 infection infection NN 74 75 . . . 77 86 Infection infection NN 87 89 of of IN 90 95 human human JJ 96 105 monocytes monocyte NNS 106 110 with with IN 111 120 influenza influenza NN 121 122 A a NN 123 128 virus virus NN 129 136 induces induce VBZ 137 138 a a DT 139 144 broad broad JJ 145 150 range range NN 151 153 of of IN 154 169 proinflammatory proinflammatory JJ 170 179 cytokines cytokine NNS 180 183 and and CC 184 195 mononuclear mononuclear JJ 196 200 cell cell NN 201 211 attracting attract VBG 212 222 chemokines chemokine NNS 223 229 before before IN 230 233 the the DT 234 242 infected infected JJ 243 248 cells cell NNS 249 256 undergo undergo VBP 257 266 apoptosis apoptosis NN 266 267 . . . 268 271 The the DT 272 282 underlying underlie VBG 283 293 mechanisms mechanism NNS 294 296 by by IN 297 302 which which WDT 303 306 the the DT 307 320 corresponding corresponding JJ 321 326 genes gene NNS 327 330 are be VBP 331 348 transcriptionally transcriptionally RB 349 358 initiated initiate VBN 359 364 after after IN 365 370 virus virus NN 371 380 infection infection NN 381 384 are be VBP 385 390 still still RB 391 397 poorly poorly RB 398 408 understood understand VBN 408 409 . . . 410 420 Activation Activation NNP 421 423 of of IN 424 432 NF-kappa NF-kappa NNP 433 434 B B NNP 435 440 seems seem VBZ 441 443 to to TO 444 448 play play VB 449 451 an an DT 452 461 important important JJ 462 466 role role NN 467 469 in in IN 470 473 the the DT 474 484 regulation regulation NN 485 487 of of IN 488 492 many many JJ 493 508 proinflammatory proinflammatory JJ 509 517 cytokine cytokine NN 518 523 genes gene NNS 523 524 , , , 525 528 but but CC 529 535 cannot cannot MD 536 538 be be VB 539 542 the the DT 543 547 only only JJ 548 557 mechanism mechanism NN 557 558 , , , 559 564 since since IN 565 572 several several JJ 573 581 cytokine cytokine NN 582 587 genes gene NNS 588 592 lack lack VBP 593 603 respective respective JJ 604 611 binding bind VBG 612 617 sites site NNS 618 620 in in IN 621 626 their their PRP$ 627 635 promoter promoter NN 636 643 regions region NNS 643 644 . . . 645 654 Therefore therefore RB 654 655 , , , 656 658 we we PRP 659 671 additionally additionally RB 672 684 investigated investigate VBD 685 690 other other JJ 691 704 transcription transcription NN 705 712 factors factor NNS 713 715 of of IN 716 724 possible possible JJ 725 735 importance importance NN 736 740 such such JJ 741 743 as as IN 744 748 CREB CREB NNP 748 749 , , , 750 753 CTF CTF NNP 753 754 , , , 755 760 OTF-1 OTF-1 NNP 760 761 , , , 762 765 and and CC 766 771 OTF-2 otf-2 NN 771 772 . . . 773 775 To to TO 776 783 explore explore VB 784 793 long-term long-term JJ 794 804 regulatory regulatory JJ 805 815 mechanisms mechanism NNS 815 816 , , , 817 819 we we PRP 820 832 investigated investigate VBD 833 836 the the DT 837 846 induction induction NN 847 849 of of IN 850 863 transcription transcription NN 864 871 factors factor NNS 872 874 on on IN 875 878 the the DT 879 883 gene gene NN 884 894 expression expression NN 895 900 level level NN 901 906 which which WDT 907 910 may may MD 911 913 be be VB 914 923 important important JJ 924 926 to to TO 927 937 substitute substitute VB 938 941 for for IN 942 953 metabolized metabolize VBN 954 967 transcription transcription NN 968 974 factor factor NN 975 983 proteins protein NNS 984 989 after after IN 990 995 their their PRP$ 996 1006 activation activation NN 1006 1007 . . . 1008 1010 We we PRP 1011 1021 identified identify VBD 1022 1023 a a DT 1024 1042 cell-type-specific cell-type-specific JJ 1043 1055 differential differential JJ 1056 1064 response response NN 1064 1065 : : : 1066 1070 CREB CREB NNP 1070 1071 , , , 1072 1075 CTF CTF NNP 1075 1076 , , , 1077 1082 OTF-1 OTF-1 NNP 1082 1083 , , , 1084 1089 OFT-2 OFT-2 NNP 1089 1090 , , , 1091 1094 and and CC 1095 1103 NF-kappa NF-kappa NNP 1104 1105 B B NNP 1106 1111 genes gene NNS 1112 1116 were be VBD 1117 1125 strongly strongly RB 1126 1133 induced induce VBN 1134 1135 1 1 CD 1136 1138 to to TO 1139 1140 4 4 CD 1141 1146 hours hour NNS 1147 1152 after after IN 1153 1162 influenza influenza NN 1163 1164 A a NN 1165 1170 virus virus NN 1171 1180 infection infection NN 1181 1183 in in IN 1184 1187 the the DT 1188 1197 monocytic monocytic JJ 1198 1202 cell cell NN 1203 1207 line line NN 1208 1212 Mono Mono NNP 1213 1216 Mac Mac NNP 1217 1218 6 6 CD 1218 1219 , , , 1220 1225 while while IN 1226 1228 in in IN 1229 1236 freshly freshly RB 1237 1245 prepared prepare VBN 1246 1251 human human JJ 1252 1261 monocytes monocyte NNS 1262 1264 no no DT 1265 1276 significant significant JJ 1277 1284 changes change NNS 1285 1289 were be VBD 1290 1298 detected detect VBN 1298 1299 . . . 1300 1302 In in IN 1303 1311 infected infected JJ 1312 1321 monocytes monocyte NNS 1321 1322 , , , 1323 1328 which which WDT 1329 1332 die die VBP 1333 1335 by by IN 1336 1345 apoptosis apoptosis NN 1345 1346 , , , 1347 1350 the the DT 1351 1361 expression expression NN 1362 1364 of of IN 1365 1369 CREB CREB NNP 1369 1370 , , , 1371 1374 CTF CTF NNP 1374 1375 , , , 1376 1379 and and CC 1380 1385 OTF-2 otf-2 NN 1386 1389 was be VBD 1390 1396 rather rather RB 1397 1407 suppressed suppress VBN 1408 1409 8 8 CD 1410 1415 hours hour NNS 1416 1421 after after IN 1422 1431 infection infection NN 1431 1432 . . . 1433 1435 In in IN 1436 1446 conclusion conclusion NN 1446 1447 , , , 1448 1451 the the DT 1452 1461 long-term long-term JJ 1462 1472 regulation regulation NN 1473 1475 of of IN 1476 1489 transcription transcription NN 1490 1496 factor factor NN 1497 1501 gene gene NN 1502 1512 expression expression NN 1513 1515 in in IN 1516 1533 non-proliferating non-proliferating JJ 1534 1539 cells cell NNS 1540 1545 seems seem VBZ 1546 1548 to to TO 1549 1551 be be VB 1552 1554 of of IN 1555 1560 minor minor JJ 1561 1571 importance importance NN 1572 1577 after after IN 1578 1587 influenza influenza NN 1588 1597 infection infection NN 1598 1603 since since IN 1604 1606 in in IN 1607 1621 apoptosisprone apoptosisprone JJ 1622 1627 cells cell NNS 1628 1630 an an DT 1631 1640 immediate immediate JJ 1641 1653 availability availability NN 1654 1656 of of IN 1657 1670 transcription transcription NN 1671 1677 factor factor NN 1678 1686 proteins protein NNS 1687 1689 is be VBZ 1690 1698 required require VBN 1698 1699 . . .