0 1 [ [ ( 1 19 Molecular-biologic molecular-biologic JJ 20 27 aspects aspect NNS 28 30 of of IN 31 42 interaction interaction NN 43 50 between between IN 51 58 nervous nervous JJ 59 62 and and CC 63 69 immune immune JJ 70 77 systems system NNS 77 78 ] ] ) 80 83 The the DT 84 91 problem problem NN 92 94 of of IN 95 98 the the DT 99 111 neuro-immuno neuro-immuno JJ 112 124 interactions interaction NNS 125 127 on on IN 128 131 the the DT 132 137 level level NN 138 140 of of IN 141 144 the the DT 145 152 protein protein NN 153 166 trans-factors trans-factor NNS 166 167 , , , 168 179 stimulating stimulate VBG 180 193 interleukin-2 interleukin-2 NN 194 195 ( ( ( 195 199 IL-2 il-2 NN 199 200 ) ) ) 201 205 gene gene NN 206 216 expression expression NN 217 220 was be VBD 221 230 discussed discuss VBN 230 231 . . . 232 235 The the DT 236 252 physico-chemical physico-chemical JJ 253 256 and and CC 257 267 functional functional JJ 268 278 parameters parameter NNS 279 281 of of IN 282 285 the the DT 286 289 low low JJ 290 299 molecular molecular JJ 300 307 nuclear nuclear JJ 308 316 proteins protein NNS 317 318 ( ( ( 318 320 SP SP NNP 321 324 and and CC 325 328 BP- BP- NNP 329 331 14 14 CD 331 332 , , , 333 335 18 18 CD 335 336 , , , 337 339 19 19 CD 340 343 kDs kd NNS 343 344 ) ) ) 345 353 isolated isolate VBN 354 358 from from IN 359 366 splenic splenic JJ 367 370 and and CC 371 376 brain brain NN 377 382 cells cell NNS 383 385 of of IN 386 395 immunized immunize VBN 396 400 rats rat NNS 401 405 were be VBD 406 413 studied study VBN 413 414 . . . 415 418 The the DT 419 426 binding binding NN 427 429 of of IN 430 435 these these DT 436 444 proteins protein NNS 445 447 to to TO 448 451 the the DT 452 462 regulatory regulatory JJ 463 469 region region NN 470 472 of of IN 473 477 IL-2 il-2 NN 478 482 gene gene NN 483 485 in in FW 486 491 vitro vitro FW 492 495 and and CC 496 507 stimulation stimulation NN 508 510 of of IN 511 514 the the DT 515 523 IL-2mRNA IL-2mRNA NNP 524 533 synthesis synthesis NN 534 536 in in IN 537 544 splenic splenic JJ 545 558 T-lymphocytes t-lymphocyte NNS 559 566 culture culture NN 567 569 in in IN 570 576 normal normal JJ 577 587 conditions condition NNS 588 592 were be VBD 593 598 shown show VBN 598 599 . . . 600 603 The the DT 604 614 protective protective JJ 615 621 effect effect NN 622 624 of of IN 625 627 SP SP NNP 628 631 and and CC 632 634 BP BP NNP 635 637 on on IN 638 641 the the DT 642 650 IL-2mRNA IL-2mRNA NNP 651 660 synthesis synthesis NN 661 663 in in IN 664 673 stressful stressful JJ 674 684 conditions condition NNS 685 688 and and CC 689 691 by by IN 692 695 the the DT 696 703 T-cells T-cell NNP 704 713 treatment treatment NN 714 718 with with IN 719 722 the the DT 723 726 CsA CsA NNP 727 730 was be VBD 731 743 demonstrated demonstrate VBN 743 744 . . .