0 9 Oxidative oxidative JJ 10 16 stress stress NN 17 27 suppresses suppress VBZ 28 41 transcription transcription NN 42 48 factor factor NN 49 59 activities activity NNS 60 62 in in IN 63 73 stimulated stimulate VBN 74 85 lymphocytes lymphocyte NNS 85 86 . . . 88 95 Effects Effect NNPS 96 98 of of IN 99 108 oxidative oxidative JJ 109 115 stress stress NN 116 118 on on IN 119 140 stimulation-dependent stimulation-dependent JJ 141 147 signal signal NN 148 160 transduction transduction NN 160 161 , , , 162 169 leading lead VBG 170 172 to to TO 173 177 IL-2 il-2 NN 178 188 expression expression NN 188 189 , , , 190 194 were be VBD 195 202 studied study VBN 202 203 . . . 204 212 Purified purify VBN 213 222 quiescent quiescent JJ 223 228 human human JJ 229 234 blood blood NN 235 236 T t NN 237 248 lymphocytes lymphocyte NNS 249 253 were be VBD 254 263 subjected subject VBN 264 266 to to TO 266 267 : : : 268 269 ( ( ( 269 270 i i LS 270 271 ) ) ) 272 277 acute acute JJ 278 286 exposure exposure NN 287 289 to to TO 290 298 hydrogen hydrogen NN 299 307 peroxide peroxide NN 307 308 ; ; : 309 310 ( ( ( 310 312 ii ii LS 312 313 ) ) ) 314 321 chronic chronic JJ 322 330 exposure exposure NN 331 333 to to TO 334 342 hydrogen hydrogen NN 343 351 peroxide peroxide NN 351 352 ; ; : 353 356 and and CC 357 358 ( ( ( 358 361 iii iii LS 361 362 ) ) ) 363 368 acute acute JJ 369 377 exposure exposure NN 378 380 to to TO 381 389 ionizing ionize VBG 390 399 radiation radiation NN 399 400 . . . 401 404 The the DT 405 410 cells cell NNS 411 415 were be VBD 416 420 then then RB 421 431 stimulated stimulate VBN 432 435 for for IN 436 437 6 6 CD 438 440 h. h. NN 441 452 DNA-binding dna-binding JJ 453 463 activities activity NNS 464 465 ( ( ( 465 475 determined determine VBN 476 478 by by IN 479 482 the the DT 483 498 electrophoretic electrophoretic JJ 499 507 mobility mobility NN 508 513 shift shift NN 514 519 assay assay NN 519 520 ) ) ) 521 523 of of IN 524 529 three three CD 530 543 transcription transcription NN 544 551 factors factor NNS 551 552 : : : 553 561 NFkappaB NFkappaB NNP 561 562 , , , 563 567 AP-1 AP-1 NNP 568 571 and and CC 572 576 NFAT NFAT NNP 576 577 , , , 578 582 were be VBD 583 592 abolished abolish VBN 593 595 in in IN 596 599 the the DT 600 611 lymphocytes lymphocyte NNS 612 614 by by IN 615 618 all all DT 619 624 three three CD 625 630 modes mode NNS 631 633 of of IN 634 643 oxidative oxidative JJ 644 650 stress stress NN 650 651 . . . 652 655 The the DT 656 667 lymphocytes lymphocyte NNS 668 677 exhibited exhibit VBD 678 683 lipid lipid NN 684 696 peroxidation peroxidation NN 697 701 only only RB 702 706 upon upon IN 707 715 exposure exposure NN 716 718 to to TO 719 722 the the DT 723 729 lowest low JJS 730 735 level level NN 736 738 of of IN 739 747 hydrogen hydrogen NN 748 756 peroxide peroxide NN 757 761 used use VBN 762 763 ( ( ( 763 765 20 20 CD 766 772 microM microM NNP 772 773 ) ) ) 773 774 . . . 775 778 All all DT 779 784 three three CD 785 790 modes mode NNS 791 793 of of IN 794 803 oxidative oxidative JJ 804 810 stress stress NN 811 818 induced induce VBD 819 827 catalase catalase NN 828 836 activity activity NN 837 839 in in IN 840 843 the the DT 844 855 lymphocytes lymphocyte NNS 855 856 . . . 857 860 The the DT 861 865 only only JJ 866 875 exception exception NN 876 879 was be VBD 880 888 hydrogen hydrogen NN 889 897 peroxide peroxide NN 898 900 at at IN 901 903 20 20 CD 904 910 microM microM NNP 910 911 , , , 912 917 which which WDT 918 921 did do VBD 922 925 not not RB 926 932 induce induce VB 933 941 catalase catalase NN 942 950 activity activity NN 950 951 . . . 952 954 We we PRP 955 963 conclude conclude VBP 964 968 that that IN 968 969 : : : 970 971 ( ( ( 971 972 i i LS 972 973 ) ) ) 974 985 suppression suppression NN 986 988 of of IN 989 997 specific specific JJ 998 1011 transcription transcription NN 1012 1018 factor factor NN 1019 1028 functions function NNS 1029 1032 can can MD 1033 1044 potentially potentially RB 1045 1050 serve serve VB 1051 1053 as as IN 1054 1055 a a DT 1056 1062 marker marker NN 1063 1065 of of IN 1066 1074 exposure exposure NN 1075 1077 to to TO 1078 1087 oxidative oxidative JJ 1088 1094 stress stress NN 1095 1098 and and CC 1099 1102 its its PRP$ 1103 1110 effects effect NNS 1111 1113 on on IN 1114 1119 human human JJ 1120 1131 lymphocytes lymphocyte NNS 1131 1132 ; ; : 1133 1134 ( ( ( 1134 1136 ii ii LS 1136 1137 ) ) ) 1138 1143 lipid lipid NN 1144 1156 peroxidation peroxidation NN 1157 1159 is be VBZ 1160 1164 only only RB 1165 1175 detectable detectable JJ 1176 1178 in in IN 1179 1184 human human JJ 1185 1196 lymphocytes lymphocyte NNS 1197 1201 upon upon IN 1202 1210 exposure exposure NN 1211 1213 to to TO 1214 1218 weak weak JJ 1219 1228 oxidative oxidative JJ 1229 1235 stress stress NN 1236 1241 which which WDT 1242 1246 does do VBZ 1247 1250 not not RB 1251 1257 induce induce VB 1258 1266 catalase catalase NN 1267 1275 activity activity NN 1275 1276 ; ; : 1277 1278 ( ( ( 1278 1281 iii iii LS 1281 1282 ) ) ) 1283 1292 therefore therefore RB 1292 1293 , , , 1294 1307 transcription transcription NN 1308 1314 factor factor NN 1315 1326 DNA-binding dna-binding JJ 1327 1337 activities activity NNS 1338 1341 are be VBP 1342 1346 more more RBR 1347 1356 sensitive sensitive JJ 1357 1359 to to TO 1360 1369 oxidative oxidative JJ 1370 1376 stress stress NN 1377 1381 than than IN 1382 1387 lipid lipid NN 1388 1400 peroxidation peroxidation NN 1400 1401 . . .