0	8	Targeted	target	VBN
9	19	disruption	disruption	NN
20	22	of	of	IN
23	26	the	the	DT
27	32	MyD88	myd88	NN
33	37	gene	gene	NN
38	45	results	result	VBZ
46	48	in	in	IN
49	53	loss	loss	NN
54	56	of	of	IN
57	62	IL-1-	IL-1-	NNP
63	66	and	and	CC
67	81	IL-18-mediated	il-18-mediated	JJ
82	90	function	function	NN
90	91	.	.	.

93	98	MyD88	myd88	NN
98	99	,	,	,
100	110	originally	originally	RB
111	119	isolated	isolate	VBN
120	122	as	as	IN
123	124	a	a	DT
125	132	myeloid	myeloid	JJ
133	148	differentiation	differentiation	NN
149	156	primary	primary	JJ
157	165	response	response	NN
166	170	gene	gene	NN
170	171	,	,	,
172	174	is	be	VBZ
175	180	shown	show	VBN
181	183	to	to	TO
184	187	act	act	VB
188	190	as	as	IN
191	193	an	an	DT
194	201	adaptor	adaptor	NN
202	204	in	in	IN
205	218	interleukin-1	interleukin-1	NN
219	220	(	(	(
220	224	IL-1	il-1	NN
224	225	)	)	)
226	235	signaling	signaling	NN
236	238	by	by	IN
239	250	interacting	interact	VBG
251	255	with	with	IN
256	260	both	both	CC
261	264	the	the	DT
265	269	IL-1	il-1	NN
270	278	receptor	receptor	NN
279	286	complex	complex	NN
287	290	and	and	CC
291	295	IL-1	il-1	NN
296	315	receptor-associated	receptor-associated	JJ
316	322	kinase	kinase	NNP
323	324	(	(	(
324	328	IRAK	IRAK	NNP
328	329	)	)	)
329	330	.	.	.

331	335	Mice	mouse	NNS
336	345	generated	generate	VBN
346	348	by	by	IN
349	353	gene	gene	NN
354	363	targeting	targeting	NN
364	366	to	to	TO
367	371	lack	lack	VB
372	377	MyD88	myd88	NN
378	382	have	have	VBP
383	390	defects	defect	NNS
391	393	in	in	IN
394	395	T	t	NN
396	400	cell	cell	NN
401	414	proliferation	proliferation	NN
415	417	as	as	RB
418	422	well	well	RB
423	425	as	as	IN
426	435	induction	induction	NN
436	438	of	of	IN
439	444	acute	acute	JJ
445	450	phase	phase	NN
451	459	proteins	protein	NNS
460	463	and	and	CC
464	473	cytokines	cytokine	NNS
474	476	in	in	IN
477	485	response	response	NN
486	488	to	to	TO
489	493	IL-1	il-1	NN
493	494	.	.	.

495	504	Increases	increase	NNS
505	507	in	in	IN
508	524	interferon-gamma	interferon-gamma	NN
525	535	production	production	NN
536	539	and	and	CC
540	547	natural	natural	JJ
548	554	killer	killer	NN
555	559	cell	cell	NN
560	568	activity	activity	NN
569	571	in	in	IN
572	580	response	response	NN
581	583	to	to	TO
584	589	IL-18	il-18	NN
590	593	are	be	VBP
594	603	abrogated	abrogate	VBN
603	604	.	.	.

605	607	In	in	FW
608	612	vivo	vivo	FW
613	616	Th1	th1	NN
617	625	response	response	NN
626	628	is	be	VBZ
629	633	also	also	RB
634	642	impaired	impaired	JJ
642	643	.	.	.

644	655	Furthermore	furthermore	RB
655	656	,	,	,
657	670	IL-18-induced	il-18-induced	JJ
671	681	activation	activation	NN
682	684	of	of	IN
685	694	NF-kappaB	NF-kappaB	NNP
695	698	and	and	CC
699	704	c-Jun	c-jun	NN
705	715	N-terminal	n-terminal	JJ
716	722	kinase	kinase	NNP
723	724	(	(	(
724	727	JNK	JNK	NNP
727	728	)	)	)
729	731	is	be	VBZ
732	739	blocked	block	VBN
740	742	in	in	IN
743	751	MyD88-/-	myd88-/-	JJ
752	766	Th1-developing	th1-developing	NN
767	772	cells	cell	NNS
772	773	.	.	.

774	779	Taken	take	VBN
780	788	together	together	RB
788	789	,	,	,
790	795	these	these	DT
796	803	results	result	NNS
804	815	demonstrate	demonstrate	VBP
816	820	that	that	IN
821	826	MyD88	myd88	NN
827	829	is	be	VBZ
830	831	a	a	DT
832	840	critical	critical	JJ
841	850	component	component	NN
851	853	in	in	IN
854	857	the	the	DT
858	867	signaling	signaling	NN
868	875	cascade	cascade	NN
876	880	that	that	WDT
881	883	is	be	VBZ
884	892	mediated	mediate	VBN
893	895	by	by	IN
896	900	IL-1	il-1	NN
901	909	receptor	receptor	NN
910	912	as	as	RB
913	917	well	well	RB
918	920	as	as	IN
921	926	IL-18	il-18	NN
927	935	receptor	receptor	NN
935	936	.	.	.