0	7	Altered	alter	VBN
8	19	DNA-binding	dna-binding	JJ
20	31	specificity	specificity	NN
32	39	mutants	mutant	NNS
40	42	of	of	IN
43	47	EKLF	EKLF	NNP
48	51	and	and	CC
52	55	Sp1	sp1	NN
56	60	show	show	VBP
61	65	that	that	IN
66	70	EKLF	eklf	NN
71	73	is	be	VBZ
74	76	an	an	DT
77	86	activator	activator	NN
87	89	of	of	IN
90	93	the	the	DT
94	105	beta-globin	beta-globin	NN
106	111	locus	locus	NN
112	119	control	control	NN
120	126	region	region	NN
127	129	in	in	FW
130	134	vivo	vivo	FW
134	135	.	.	.

137	140	The	the	DT
141	146	locus	locus	NN
147	154	control	control	NN
155	161	region	region	NN
162	164	of	of	IN
165	168	the	the	DT
169	180	beta-globin	beta-globin	NN
181	188	cluster	cluster	NN
189	197	contains	contain	VBZ
198	202	five	five	CD
203	208	DNase	DNase	NNP
209	210	I	i	CD
211	225	hypersensitive	hypersensitive	JJ
226	231	sites	site	NNS
232	233	(	(	(
233	240	5’HS1-5	5'hs1-5	NN
240	241	)	)	)
242	250	required	require	VBN
251	254	for	for	IN
255	260	locus	locus	NN
261	271	activation	activation	NN
271	272	.	.	.

273	278	5’HS3	5'hs3	NN
279	287	contains	contain	VBZ
288	291	six	six	CD
292	298	G-rich	g-rich	JJ
299	305	motifs	motif	NNS
306	310	that	that	WDT
311	314	are	be	VBP
315	324	essential	essential	JJ
325	328	for	for	IN
329	332	its	its	PRP$
333	341	activity	activity	NN
341	342	.	.	.

343	350	Members	member	NNS
351	353	of	of	IN
354	355	a	a	DT
356	363	protein	protein	NN
364	370	family	family	NN
370	371	,	,	,
372	385	characterized	characterize	VBN
386	388	by	by	IN
389	394	three	three	CD
395	399	zinc	zinc	NN
400	407	fingers	finger	NNS
408	414	highly	highly	RB
415	425	homologous	homologous	JJ
426	428	to	to	TO
429	434	those	those	DT
435	440	found	find	VBN
441	443	in	in	IN
444	457	transcription	transcription	NN
458	464	factor	factor	NN
465	468	Sp1	sp1	NN
468	469	,	,	,
470	478	interact	interact	VBP
479	483	with	with	IN
484	489	these	these	DT
490	496	motifs	motif	NNS
496	497	.	.	.

498	505	Because	because	IN
506	511	point	point	NN
512	523	mutagenesis	mutagenesis	NN
524	530	cannot	cannot	MD
531	542	distinguish	distinguish	VB
543	550	between	between	IN
551	557	family	family	NN
558	565	members	member	NNS
565	566	,	,	,
567	569	it	it	PRP
570	572	is	be	VBZ
573	576	not	not	RB
577	582	known	know	VBN
583	588	which	which	WDT
589	596	protein	protein	NN
597	606	activates	activate	VBZ
607	612	5’HS3	5'hs3	NN
612	613	.	.	.

614	616	We	we	PRP
617	621	show	show	VBP
622	626	that	that	IN
627	630	the	the	DT
631	639	function	function	NN
640	642	of	of	IN
643	647	such	such	JJ
648	655	closely	closely	RB
656	663	related	related	JJ
664	672	proteins	protein	NNS
673	676	can	can	MD
677	679	be	be	VB
680	693	distinguished	distinguish	VBN
694	696	in	in	FW
697	701	vivo	vivo	FW
702	704	by	by	IN
705	713	matching	match	VBG
714	719	point	point	NN
720	729	mutations	mutation	NNS
730	732	in	in	IN
733	738	5’HS3	5'hs3	NN
739	743	with	with	IN
744	749	amino	amino	JJ
750	754	acid	acid	NN
755	762	changes	change	NNS
763	765	in	in	IN
766	769	the	the	DT
770	774	zinc	zinc	NN
775	782	fingers	finger	NNS
783	785	of	of	IN
786	789	Sp1	Sp1	NNP
790	793	and	and	CC
794	798	EKLF	EKLF	NNP
798	799	.	.	.

800	807	Testing	test	VBG
808	813	their	their	PRP$
814	822	activity	activity	NN
823	825	in	in	IN
826	836	transgenic	transgenic	JJ
837	841	mice	mouse	NNS
842	847	shows	show	VBZ
848	852	that	that	IN
853	857	EKLF	eklf	NN
858	860	is	be	VBZ
861	862	a	a	DT
863	869	direct	direct	JJ
870	879	activator	activator	NN
880	882	of	of	IN
883	888	5’HS3	5'hs3	NN
888	889	.	.	.