0	1	A	a	DT
2	10	critical	critical	JJ
11	15	role	role	NN
16	18	of	of	IN
19	22	the	the	DT
23	26	p75	p75	NN
27	32	tumor	tumor	NN
33	41	necrosis	necrosis	NN
42	48	factor	factor	NN
49	57	receptor	receptor	NN
58	59	(	(	(
59	67	p75TNF-R	p75TNF-R	NNP
67	68	)	)	)
69	71	in	in	IN
72	77	organ	organ	NN
78	90	inflammation	inflammation	NN
91	102	independent	independent	JJ
103	105	of	of	IN
106	109	TNF	TNF	NNP
109	110	,	,	,
111	122	lymphotoxin	lymphotoxin	NN
123	128	alpha	alpha	NN
128	129	,	,	,
130	132	or	or	CC
133	136	the	the	DT
137	145	p55TNF-R	p55TNF-R	NNP
145	146	.	.	.

148	155	Despite	despite	IN
156	168	overwhelming	overwhelming	JJ
169	177	evidence	evidence	NN
178	182	that	that	IN
183	191	enhanced	enhance	VBN
192	202	production	production	NN
203	205	of	of	IN
206	209	the	the	DT
210	213	p75	p75	NN
214	219	tumor	tumor	NN
220	228	necrosis	necrosis	NN
229	235	factor	factor	NN
236	244	receptor	receptor	NN
245	246	(	(	(
246	254	p75TNF-R	p75TNF-R	NNP
254	255	)	)	)
256	267	accompanies	accompany	VBZ
268	279	development	development	NN
280	282	of	of	IN
283	291	specific	specific	JJ
292	297	human	human	JJ
298	310	inflammatory	inflammatory	JJ
311	322	pathologies	pathology	NNS
323	327	such	such	JJ
328	330	as	as	IN
331	342	multi-organ	multi-organ	JJ
343	350	failure	failure	NN
351	357	during	during	IN
358	364	sepsis	sepsis	NN
364	365	,	,	,
366	378	inflammatory	inflammatory	JJ
379	384	liver	liver	NN
385	392	disease	disease	NN
392	393	,	,	,
394	406	pancreatitis	pancreatitis	NNP
406	407	,	,	,
408	419	respiratory	respiratory	JJ
420	428	distress	distress	NN
429	437	syndrome	syndrome	NN
437	438	,	,	,
439	441	or	or	CC
442	446	AIDS	AIDS	NNP
446	447	,	,	,
448	451	the	the	DT
452	460	function	function	NN
461	463	of	of	IN
464	468	this	this	DT
469	477	receptor	receptor	NN
478	485	remains	remain	VBZ
486	492	poorly	poorly	RB
493	500	defined	define	VBN
501	503	in	in	FW
504	508	vivo	vivo	FW
508	509	.	.	.

510	512	We	we	PRP
513	517	show	show	VBP
518	522	here	here	RB
523	527	that	that	IN
528	530	at	at	IN
531	537	levels	level	NNS
538	546	relevant	relevant	JJ
547	549	to	to	TO
550	555	human	human	JJ
556	563	disease	disease	NN
563	564	,	,	,
565	575	production	production	NN
576	578	of	of	IN
579	582	the	the	DT
583	588	human	human	JJ
589	597	p75TNF-R	p75TNF-R	NNP
598	600	in	in	IN
601	611	transgenic	transgenic	JJ
612	616	mice	mouse	NNS
617	624	results	result	VBZ
625	627	in	in	IN
628	629	a	a	DT
630	636	severe	severe	JJ
637	649	inflammatory	inflammatory	JJ
650	658	syndrome	syndrome	NN
659	668	involving	involve	VBG
669	675	mainly	mainly	RB
676	679	the	the	DT
680	688	pancreas	pancreas	NN
688	689	,	,	,
690	695	liver	liver	NN
695	696	,	,	,
697	703	kidney	kidney	NN
703	704	,	,	,
705	708	and	and	CC
709	713	lung	lung	NN
713	714	,	,	,
715	718	and	and	CC
719	732	characterized	characterize	VBN
733	735	by	by	IN
736	750	constitutively	constitutively	RB
751	760	increased	increase	VBN
761	770	NF-kappaB	NF-kappaB	NNP
771	779	activity	activity	NN
780	782	in	in	IN
783	786	the	the	DT
787	797	peripheral	peripheral	JJ
798	803	blood	blood	NN
804	815	mononuclear	mononuclear	JJ
816	820	cell	cell	NN
821	832	compartment	compartment	NN
832	833	.	.	.

834	838	This	this	DT
839	846	process	process	NN
847	849	is	be	VBZ
850	855	shown	show	VBN
856	858	to	to	TO
859	865	evolve	evolve	VB
866	879	independently	independently	RB
880	882	of	of	IN
883	886	the	the	DT
887	895	presence	presence	NN
896	898	of	of	IN
899	902	TNF	TNF	NNP
902	903	,	,	,
904	915	lymphotoxin	lymphotoxin	NN
916	921	alpha	alpha	NN
921	922	,	,	,
923	925	or	or	CC
926	929	the	the	DT
930	938	p55TNF-R	p55TNF-R	NNP
938	939	,	,	,
940	948	although	although	IN
949	961	coexpression	coexpression	NN
962	964	of	of	IN
965	966	a	a	DT
967	972	human	human	JJ
973	976	TNF	tnf	NN
977	986	transgene	transgene	NN
987	998	accelerated	accelerate	VBD
999	1008	pathology	pathology	NN
1008	1009	.	.	.

1010	1015	These	these	DT
1016	1023	results	result	NNS
1024	1033	establish	establish	VBP
1034	1036	an	an	DT
1037	1048	independent	independent	JJ
1049	1053	role	role	NN
1054	1057	for	for	IN
1058	1066	enhanced	enhance	VBN
1067	1075	p75TNF-R	p75TNF-R	NNP
1076	1086	production	production	NN
1087	1089	in	in	IN
1090	1093	the	the	DT
1094	1106	pathogenesis	pathogenesis	NN
1107	1109	of	of	IN
1110	1122	inflammatory	inflammatory	JJ
1123	1130	disease	disease	NN
1131	1134	and	and	CC
1135	1144	implicate	implicate	VBP
1145	1148	the	the	DT
1149	1155	direct	direct	JJ
1156	1167	involvement	involvement	NN
1168	1170	of	of	IN
1171	1175	this	this	DT
1176	1184	receptor	receptor	NN
1185	1187	in	in	IN
1188	1189	a	a	DT
1190	1194	wide	wide	JJ
1195	1200	range	range	NN
1201	1203	of	of	IN
1204	1209	human	human	JJ
1210	1222	inflammatory	inflammatory	JJ
1223	1234	pathologies	pathology	NNS
1234	1235	.	.	.