0 7 Tobacco Tobacco NNP 8 13 smoke smoke NN 14 21 induces induce VBZ 22 32 coordinate coordinate JJ 33 43 activation activation NN 44 46 of of IN 47 50 HSF HSF NNP 51 54 and and CC 55 65 inhibition inhibition NN 66 68 of of IN 69 77 NFkappaB NFkappaB NNP 78 80 in in IN 81 86 human human JJ 87 96 monocytes monocyte NNS 96 97 : : : 98 105 effects effect NNS 106 108 on on IN 109 117 TNFalpha TNFalpha NNP 118 125 release release NN 125 126 . . . 128 135 Tobacco Tobacco NNP 136 141 smoke smoke NN 142 143 ( ( ( 143 145 TS TS NNP 145 146 ) ) ) 147 155 exposure exposure NN 156 158 is be VBZ 159 160 a a DT 161 166 major major JJ 167 171 risk risk NN 172 178 factor factor NN 179 182 for for IN 183 188 human human JJ 189 196 disease disease NN 196 197 , , , 198 201 and and CC 202 213 macrophages macrophage NNS 214 216 of of IN 217 224 healthy healthy JJ 225 232 smokers smoker NNS 233 237 have have VBP 238 239 a a DT 240 249 depressed depress VBN 250 258 capacity capacity NN 259 261 to to TO 262 269 release release VB 270 279 cytokines cytokine NNS 279 280 , , , 281 290 including include VBG 291 296 tumor tumor NN 297 305 necrosis necrosis NN 306 312 factor factor NN 313 314 ( ( ( 314 323 TNF)alpha TNF)alpha NNP 323 324 . . . 325 327 TS TS NNP 328 335 induces induce VBZ 336 339 the the DT 340 349 synthesis synthesis NN 350 352 of of IN 353 357 heat heat NN 358 363 shock shock NN 364 365 ( ( ( 365 375 HS)/stress HS)/stress NNP 376 384 proteins protein NNS 385 386 ( ( ( 386 389 HSP HSP NNP 389 390 ) ) ) 390 391 , , , 392 395 and and CC 395 396 , , , 397 399 in in IN 400 410 particular particular JJ 410 411 , , , 412 414 of of IN 415 420 Hsp70 Hsp70 NNP 420 421 . . . 422 424 We we PRP 425 435 determined determine VBD 436 443 whether whether IN 444 449 Hsp70 hsp70 NN 450 459 induction induction NN 460 462 by by IN 463 465 TS ts NN 466 469 was be VBD 470 478 mediated mediate VBN 479 481 by by IN 482 485 the the DT 486 496 activation activation NN 497 499 of of IN 500 503 the the DT 504 506 HS HS NNP 507 520 transcription transcription NN 521 527 factor factor NN 527 528 , , , 529 532 HSF HSF NNP 532 533 . . . 534 537 HSF HSF NNP 538 548 activation activation NN 549 552 has have VBZ 553 557 been be VBN 558 563 shown show VBN 564 566 to to TO 567 574 inhibit inhibit VB 575 583 NFkappaB NFkappaB NNP 583 584 . . . 585 589 Thus thus RB 589 590 , , , 591 593 we we PRP 594 598 also also RB 599 609 determined determine VBD 610 613 the the DT 614 621 effects effect NNS 622 624 of of IN 625 627 TS ts NN 628 630 on on IN 631 639 NFkappaB NFkappaB NNP 639 640 . . . 641 645 U937 u937 NN 646 651 cells cell NNS 652 655 and and CC 656 661 human human JJ 662 672 peripheral peripheral JJ 673 678 blood blood NN 679 688 monocytes monocyte NNS 689 693 were be VBD 694 701 exposed expose VBN 702 704 to to TO 705 707 TS ts NN 707 708 , , , 709 716 binding binding NN 717 727 activities activity NNS 728 730 of of IN 731 734 the the DT 735 745 respective respective JJ 746 759 transcription transcription NN 760 767 factors factor NNS 768 772 were be VBD 773 781 analyzed analyze VBN 781 782 , , , 783 786 and and CC 787 792 Hsp70 hsp70 NN 793 803 expression expression NN 804 807 and and CC 808 816 TNFalpha TNFalpha NNP 817 824 release release NN 825 829 were be VBD 830 840 determined determine VBN 841 843 in in IN 844 852 parallel parallel NN 852 853 . . . 854 856 TS ts NN 857 866 activated activate VBD 867 870 HSF HSF NNP 870 871 , , , 872 877 which which WDT 878 881 was be VBD 882 892 associated associate VBN 893 897 with with IN 898 903 Hsp70 hsp70 NN 904 918 overexpression overexpression NN 919 922 and and CC 923 933 inhibition inhibition NN 934 936 of of IN 937 945 NFkappaB NFkappaB NNP 946 953 binding binding NN 954 962 activity activity NN 963 966 and and CC 967 975 TNFalpha TNFalpha NNP 976 983 release release NN 983 984 . . . 985 988 The the DT 989 996 altered altered JJ 997 1005 cytokine cytokine NN 1006 1013 profile profile NN 1014 1022 observed observe VBN 1023 1025 in in IN 1026 1033 smokers smoker NNS 1034 1037 may may MD 1038 1044 relate relate VB 1045 1047 to to TO 1048 1050 an an DT 1051 1069 HSF/Hsp70-mediated hsf/hsp70-mediated JJ 1070 1080 inhibition inhibition NN 1081 1083 of of IN 1084 1092 NFkappaB NFkappaB NNP 1093 1101 activity activity NN 1101 1102 . . . 1103 1112 Copyright Copyright NNP 1113 1117 1998 1998 CD 1118 1126 Academic Academic NNP 1127 1132 Press Press NNP 1132 1133 . . .