0	4	TAL1	tal1	NN
5	8	and	and	CC
9	17	LIM-only	lim-only	JJ
18	26	proteins	protein	NNS
27	42	synergistically	synergistically	RB
43	49	induce	induce	VBP
50	63	retinaldehyde	retinaldehyde	NN
64	77	dehydrogenase	dehydrogenase	NN
78	79	2	2	CD
80	90	expression	expression	NN
91	93	in	in	IN
94	100	T-cell	t-cell	NN
101	106	acute	acute	JJ
107	120	lymphoblastic	lymphoblastic	JJ
121	129	leukemia	leukemia	NN
130	132	by	by	IN
133	139	acting	act	VBG
140	142	as	as	IN
143	152	cofactors	cofactor	NNS
153	156	for	for	IN
157	162	GATA3	GATA3	NNP
162	163	.	.	.

165	175	Previously	previously	RB
175	176	,	,	,
177	179	we	we	PRP
180	184	have	have	VBP
185	190	shown	show	VBN
191	195	that	that	IN
196	200	TAL1	TAL1	NNP
201	204	and	and	CC
205	208	the	the	DT
209	217	LIM-only	lim-only	JJ
218	225	protein	protein	NN
226	230	gene	gene	NN
231	232	(	(	(
232	235	LMO	LMO	NNP
235	236	)	)	)
237	240	are	be	VBP
241	250	regularly	regularly	RB
251	262	coactivated	coactivate	VBN
263	265	in	in	IN
266	272	T-cell	t-cell	NN
273	278	acute	acute	JJ
279	292	lymphoblastic	lymphoblastic	JJ
293	301	leukemia	leukemia	NN
302	303	(	(	(
303	308	T-ALL	T-ALL	NNP
308	309	)	)	)
309	310	.	.	.

311	315	This	this	DT
316	327	observation	observation	NN
328	330	is	be	VBZ
331	337	likely	likely	JJ
338	340	to	to	TO
341	347	relate	relate	VB
348	350	to	to	TO
351	354	the	the	DT
355	363	findings	finding	NNS
364	368	that	that	IN
369	373	TAL1	TAL1	NNP
374	377	and	and	CC
378	381	LMO	LMO	NNP
382	385	are	be	VBP
386	392	highly	highly	RB
393	404	synergistic	synergistic	JJ
405	407	in	in	IN
408	414	T-cell	t-cell	NN
415	428	tumorigenesis	tumorigenesis	NN
429	431	in	in	IN
432	449	double-transgenic	double-transgenic	JJ
450	454	mice	mouse	NNS
454	455	.	.	.

456	458	To	to	TO
459	469	understand	understand	VB
470	473	the	the	DT
474	483	molecular	molecular	JJ
484	494	mechanisms	mechanism	NNS
495	497	of	of	IN
498	508	functional	functional	JJ
509	516	synergy	synergy	NN
517	524	between	between	IN
525	529	TAL1	TAL1	NNP
530	533	and	and	CC
534	537	LMO	LMO	NNP
538	540	in	in	IN
541	554	tumorigenesis	tumorigenesis	NN
555	558	and	and	CC
559	574	transcriptional	transcriptional	JJ
575	585	regulation	regulation	NN
585	586	,	,	,
587	589	we	we	PRP
590	595	tried	try	VBD
596	598	to	to	TO
599	607	identify	identify	VB
608	618	downstream	downstream	JJ
619	625	target	target	NN
626	631	genes	gene	NNS
632	641	regulated	regulate	VBN
642	644	by	by	IN
645	649	TAL1	TAL1	NNP
650	653	and	and	CC
654	657	LMO	LMO	NNP
658	660	by	by	IN
661	662	a	a	DT
663	674	subtractive	subtractive	JJ
675	678	PCR	pcr	NN
679	685	method	method	NN
685	686	.	.	.

687	690	One	one	CD
691	693	of	of	IN
694	697	the	the	DT
698	706	isolated	isolate	VBN
707	712	genes	gene	NNS
712	713	,	,	,
714	718	that	that	IN
719	722	for	for	IN
723	736	retinaldehyde	retinaldehyde	NN
737	750	dehydrogenase	dehydrogenase	NN
751	752	2	2	CD
753	754	(	(	(
754	760	RALDH2	raldh2	NN
760	761	)	)	)
761	762	,	,	,
763	766	was	be	VBD
767	776	regularly	regularly	RB
777	786	expressed	express	VBN
787	789	in	in	IN
790	794	most	most	JJS
795	797	of	of	IN
798	801	the	the	DT
802	807	T-ALL	T-ALL	NNP
808	812	cell	cell	NN
813	818	lines	line	NNS
819	823	that	that	WDT
824	835	coexpressed	coexpresse	VBD
836	840	TAL1	tal1	NN
841	844	and	and	CC
845	848	LMO	LMO	NNP
848	849	.	.	.

850	861	Exogenously	exogenously	RB
862	873	transfected	transfecte	VBN
874	878	TAL1	TAL1	NNP
879	882	and	and	CC
883	886	LMO	LMO	NNP
886	887	,	,	,
888	891	but	but	CC
892	895	not	not	RB
896	902	either	either	DT
903	908	alone	alone	RB
908	909	,	,	,
910	917	induced	induce	VBD
918	924	RALDH2	raldh2	NN
925	935	expression	expression	NN
936	938	in	in	IN
939	940	a	a	DT
941	946	T-ALL	T-ALL	NNP
947	951	cell	cell	NN
952	956	line	line	NN
956	957	,	,	,
958	965	HPB-ALL	HPB-ALL	NNP
965	966	,	,	,
967	970	not	not	RB
971	981	expressing	express	VBG
982	993	endogeneous	endogeneous	JJ
994	998	TAL1	tal1	NN
999	1001	or	or	CC
1002	1005	LMO	LMO	NNP
1005	1006	.	.	.

1007	1010	The	the	DT
1011	1017	RALDH2	raldh2	NN
1018	1029	transcripts	transcript	NNS
1030	1032	in	in	IN
1033	1038	T-ALL	T-ALL	NNP
1039	1043	were	be	VBD
1043	1044	,	,	,
1045	1052	however	however	RB
1052	1053	,	,	,
1054	1060	mostly	mostly	RB
1061	1070	initiated	initiate	VBN
1071	1077	within	within	IN
1078	1081	the	the	DT
1082	1088	second	second	JJ
1089	1095	intron	intron	NN
1095	1096	.	.	.

1097	1105	Promoter	promoter	NN
1106	1114	analysis	analysis	NN
1115	1123	revealed	reveal	VBD
1124	1128	that	that	IN
1129	1130	a	a	DT
1131	1135	GATA	GATA	NNP
1136	1140	site	site	NN
1141	1143	in	in	IN
1144	1145	a	a	DT
1146	1153	cryptic	cryptic	JJ
1154	1162	promoter	promoter	NN
1163	1165	in	in	IN
1166	1169	the	the	DT
1170	1176	second	second	JJ
1177	1183	intron	intron	NN
1184	1187	was	be	VBD
1188	1197	essential	essential	JJ
1198	1201	and	and	CC
1202	1212	sufficient	sufficient	JJ
1213	1216	for	for	IN
1217	1220	the	the	DT
1221	1226	TAL1-	TAL1-	NNP
1227	1230	and	and	CC
1231	1244	LMO-dependent	lmo-dependent	JJ
1245	1260	transcriptional	transcriptional	JJ
1261	1271	activation	activation	NN
1271	1272	,	,	,
1273	1276	and	and	CC
1277	1282	GATA3	gata3	NN
1283	1288	binds	bind	VBZ
1289	1291	to	to	TO
1292	1296	this	this	DT
1297	1301	site	site	NN
1301	1302	.	.	.

1303	1305	In	in	IN
1306	1314	addition	addition	NN
1314	1315	,	,	,
1316	1322	forced	force	VBN
1323	1333	expression	expression	NN
1334	1336	of	of	IN
1337	1342	GATA3	gata3	NN
1343	1354	potentiated	potentiate	VBD
1355	1358	the	the	DT
1359	1368	induction	induction	NN
1369	1371	of	of	IN
1372	1378	RALDH2	raldh2	NN
1379	1381	by	by	IN
1382	1386	TAL1	TAL1	NNP
1387	1390	and	and	CC
1391	1394	LMO	LMO	NNP
1394	1395	,	,	,
1396	1399	and	and	CC
1400	1405	these	these	DT
1406	1411	three	three	CD
1412	1419	factors	factor	NNS
1420	1426	formed	form	VBD
1427	1428	a	a	DT
1429	1436	complex	complex	NN
1437	1439	in	in	FW
1440	1444	vivo	vivo	FW
1444	1445	.	.	.

1446	1457	Furthermore	furthermore	RB
1457	1458	,	,	,
1459	1460	a	a	DT
1461	1465	TAL1	tal1	NN
1466	1472	mutant	mutant	NN
1473	1476	not	not	RB
1477	1484	binding	bind	VBG
1485	1487	to	to	TO
1488	1491	DNA	DNA	NNP
1492	1496	also	also	RB
1497	1506	activated	activate	VBD
1507	1510	the	the	DT
1511	1524	transcription	transcription	NN
1525	1527	of	of	IN
1528	1534	RALDH2	raldh2	NN
1535	1537	in	in	IN
1538	1541	the	the	DT
1542	1550	presence	presence	NN
1551	1553	of	of	IN
1554	1557	LMO	LMO	NNP
1558	1561	and	and	CC
1562	1567	GATA3	GATA3	NNP
1567	1568	.	.	.

1569	1581	Collectively	collectively	RB
1581	1582	,	,	,
1583	1585	we	we	PRP
1586	1590	have	have	VBP
1591	1601	identified	identify	VBN
1602	1605	the	the	DT
1606	1612	RALDH2	raldh2	NN
1613	1617	gene	gene	NN
1618	1620	as	as	IN
1621	1622	a	a	DT
1623	1628	first	first	JJ
1629	1636	example	example	NN
1637	1639	of	of	IN
1640	1646	direct	direct	JJ
1647	1662	transcriptional	transcriptional	JJ
1663	1669	target	target	NN
1670	1675	genes	gene	NNS
1676	1685	regulated	regulate	VBN
1686	1688	by	by	IN
1689	1693	TAL1	TAL1	NNP
1694	1697	and	and	CC
1698	1701	LMO	LMO	NNP
1702	1704	in	in	IN
1705	1710	T-ALL	T-ALL	NNP
1710	1711	.	.	.

1712	1714	In	in	IN
1715	1719	this	this	DT
1720	1724	case	case	NN
1724	1725	,	,	,
1726	1730	TAL1	TAL1	NNP
1731	1734	and	and	CC
1735	1738	LMO	LMO	NNP
1739	1742	act	act	VBP
1743	1745	as	as	IN
1746	1755	cofactors	cofactor	NNS
1756	1759	for	for	IN
1760	1765	GATA3	gata3	NN
1766	1768	to	to	TO
1769	1777	activate	activate	VB
1778	1781	the	the	DT
1782	1795	transcription	transcription	NN
1796	1798	of	of	IN
1799	1805	RALDH2	raldh2	NN
1805	1806	.	.	.