0 2 In in FW 3 8 vitro vitro FW 9 20 suppression suppression NN 21 23 of of IN 24 34 programmed program VBN 35 39 cell cell NN 40 45 death death NN 46 48 of of IN 49 50 B B NNP 51 56 cells cell NNS 57 59 by by IN 60 66 tissue tissue NN 67 76 inhibitor inhibitor NN 77 79 of of IN 80 100 metalloproteinases-1 metalloproteinases-1 NN 100 101 . . . 103 111 Cellular cellular JJ 112 120 pathways pathway NNS 121 124 for for IN 125 134 induction induction NN 135 137 of of IN 138 148 programmed program VBN 149 153 cell cell NN 154 159 death death NN 160 161 ( ( ( 161 164 PCD PCD NNP 164 165 ) ) ) 166 170 have have VBP 171 175 been be VBN 176 186 identified identify VBN 186 187 , , , 188 191 but but CC 192 198 little little JJ 199 201 is be VBZ 202 207 known know VBN 208 213 about about IN 214 222 specific specific JJ 223 236 extracellular extracellular JJ 237 243 matrix matrix NN 244 253 processes process NNS 254 258 that that WDT 259 262 may may MD 263 269 affect affect VB 270 279 apoptosis apoptosis NN 280 285 along along IN 286 291 those those DT 292 300 pathways pathway NNS 300 301 . . . 302 304 In in IN 305 309 this this DT 310 315 study study NN 315 316 , , , 317 318 a a DT 319 325 series series NN 326 328 of of IN 329 336 Burkitt Burkitt NNP 336 338 ’s 's POS 339 347 lymphoma lymphoma NN 348 349 ( ( ( 349 351 BL BL NNP 351 352 ) ) ) 353 357 cell cell NN 358 363 lines line NNS 364 368 were be VBD 369 376 assayed assay VBN 377 380 for for IN 381 386 their their PRP$ 387 397 expression expression NN 398 400 of of IN 401 407 tissue tissue NN 408 417 inhibitor inhibitor NN 418 420 of of IN 421 439 metalloproteinases metalloproteinas NNS 440 441 ( ( ( 441 448 TIMP)-1 TIMP)-1 NNP 448 449 . . . 450 457 Results result NNS 458 466 indicate indicate VBP 467 471 that that IN 472 487 TIMP-1-positive timp-1-positive JJ 488 490 BL BL NNP 491 496 lines line NNS 497 501 show show VBP 502 512 resistance resistance NN 513 515 to to TO 516 534 cold-shock-induced cold-shock-induced JJ 535 544 apoptosis apoptosis NN 544 545 . . . 546 557 Furthermore furthermore RB 557 558 , , , 559 570 recombinant recombinant JJ 571 577 TIMP-1 timp-1 NN 577 578 , , , 579 582 but but CC 583 586 not not RB 587 593 TIMP-2 timp-2 NN 594 596 or or CC 597 598 a a DT 599 608 synthetic synthetic JJ 609 626 metalloproteinase metalloproteinase NN 627 636 inhibitor inhibitor NN 637 638 ( ( ( 638 643 BB-94 bb-94 NN 643 644 ) ) ) 644 645 , , , 646 653 confers confer VBZ 654 664 resistance resistance NN 665 667 to to TO 668 677 apoptosis apoptosis NN 678 685 induced induce VBN 686 688 by by IN 689 693 both both CC 694 708 CD95-dependent cd95-dependent JJ 709 712 and and CC 713 725 -independent -independent JJ 726 727 ( ( ( 727 731 cold cold JJ 732 737 shock shock NN 737 738 , , , 739 744 serum serum NN 745 756 deprivation deprivation NN 756 757 , , , 758 761 and and CC 762 777 gamma-radiation gamma-radiation NN 777 778 ) ) ) 779 787 pathways pathway NNS 788 790 in in IN 791 806 TIMP-1-negative timp-1-negative JJ 807 809 BL BL NNP 810 815 lines line NNS 815 816 . . . 817 823 TIMP-1 timp-1 NN 824 835 suppression suppression NN 836 838 of of IN 839 842 PCD PCD NNP 843 845 is be VBZ 846 849 not not RB 850 853 due due JJ 854 856 to to TO 857 874 metalloproteinase metalloproteinase NN 875 885 inhibition inhibition NN 885 886 , , , 887 889 as as IN 890 899 reduction reduction NN 900 903 and and CC 904 914 alkylation alkylation NN 915 917 of of IN 918 921 the the DT 922 928 TIMP-1 timp-1 NN 929 932 did do VBD 933 936 not not RB 937 944 abolish abolish VB 945 949 this this DT 950 958 activity activity NN 958 959 . . . 960 970 Retroviral retroviral JJ 971 980 induction induction NN 981 983 of of IN 984 990 TIMP-1 timp-1 NN 991 994 not not RB 995 999 only only RB 1000 1008 resulted result VBD 1009 1011 in in IN 1012 1016 cell cell NN 1017 1025 survival survival NN 1026 1029 but but CC 1030 1034 also also RB 1035 1037 in in IN 1038 1047 continued continued JJ 1048 1051 DNA dna NN 1052 1061 synthesis synthesis NN 1062 1065 for for IN 1066 1068 up up RB 1069 1071 to to TO 1072 1073 5 5 CD 1074 1075 d d NN 1076 1078 in in IN 1079 1082 the the DT 1083 1090 absence absence NN 1091 1093 of of IN 1094 1099 serum serum NN 1099 1100 , , , 1101 1106 while while IN 1107 1115 controls control NNS 1116 1125 underwent undergo VBD 1126 1135 apoptosis apoptosis NN 1135 1136 . . . 1137 1141 This this DT 1142 1152 resistance resistance NN 1153 1155 to to TO 1156 1165 apoptosis apoptosis NN 1166 1168 is be VBZ 1169 1177 reversed reverse VBN 1178 1180 by by IN 1181 1192 anti-TIMP-1 anti-timp-1 JJ 1193 1203 antibodies antibody NNS 1203 1204 , , , 1205 1218 demonstrating demonstrate VBG 1219 1223 that that IN 1224 1232 secreted secrete VBN 1233 1239 TIMP-1 timp-1 NN 1240 1242 is be VBZ 1243 1249 active active JJ 1250 1252 in in IN 1253 1261 blocking block VBG 1262 1271 apoptosis apoptosis NN 1271 1272 . . . 1273 1284 Furthermore furthermore RB 1284 1285 , , , 1286 1292 TIMP-1 timp-1 NN 1293 1305 upregulation upregulation NN 1306 1313 induced induce VBD 1314 1324 expression expression NN 1325 1327 of of IN 1328 1334 Bcl-XL Bcl-XL NNP 1335 1338 but but CC 1339 1342 not not RB 1343 1348 Bcl-2 bcl-2 NN 1349 1351 as as RB 1352 1356 well well RB 1357 1359 as as IN 1360 1369 decreased decrease VBN 1370 1379 NF-kappaB NF-kappaB NNP 1380 1388 activity activity NN 1389 1391 as as IN 1392 1400 compared compare VBN 1401 1405 with with IN 1406 1414 controls control NNS 1414 1415 . . . 1416 1421 These these DT 1422 1429 results result NNS 1430 1441 demonstrate demonstrate VBP 1442 1446 that that IN 1447 1453 TIMP-1 timp-1 NN 1454 1464 suppresses suppress VBZ 1465 1474 apoptosis apoptosis NN 1475 1477 in in IN 1478 1479 B B NNP 1480 1485 cells cell NNS 1486 1489 and and CC 1490 1498 suggests suggest VBZ 1499 1500 a a DT 1501 1506 novel novel JJ 1507 1515 activity activity NN 1516 1519 for for IN 1520 1526 TIMP-1 timp-1 NN 1527 1529 in in IN 1530 1536 tissue tissue NN 1537 1548 homeostasis homeostasis NN 1548 1549 . . .