0	3	The	the	DT
4	11	control	control	NN
12	14	of	of	IN
15	20	lytic	lytic	JJ
21	32	replication	replication	NN
33	35	of	of	IN
36	48	Epstein-Barr	epstein-barr	JJ
49	54	virus	virus	NN
55	57	in	in	IN
58	59	B	B	NNP
60	71	lymphocytes	lymphocyte	NNS
72	73	(	(	(
73	79	Review	Review	NNP
79	80	)	)	)
80	81	.	.	.

83	95	Uncontrolled	uncontrolled	JJ
96	107	replication	replication	NN
108	110	of	of	IN
111	112	a	a	DT
113	118	virus	virus	NN
118	119	,	,	,
120	125	which	which	WDT
126	128	is	be	VBZ
129	136	harmful	harmful	JJ
137	139	to	to	TO
140	143	the	the	DT
144	148	host	host	NN
149	151	is	be	VBZ
152	156	also	also	RB
157	172	disadvantageous	disadvantageous	JJ
173	175	to	to	TO
176	179	the	the	DT
180	185	virus	virus	NN
185	186	.	.	.

187	191	Most	most	JJS
192	199	viruses	virus	NNS
200	206	cannot	cannot	MD
207	214	compete	compete	VB
215	219	with	with	IN
220	223	the	the	DT
224	231	various	various	JJ
232	238	immune	immune	JJ
239	249	mechanisms	mechanism	NNS
250	253	and	and	CC
254	260	become	become	VBP
261	271	eliminated	eliminate	VBN
272	274	in	in	IN
275	278	the	the	DT
279	285	course	course	NN
286	288	of	of	IN
289	298	infection	infection	NN
298	299	.	.	.

300	309	Therefore	therefore	RB
309	310	,	,	,
311	315	only	only	RB
316	319	the	the	DT
320	324	time	time	NN
325	332	between	between	IN
333	342	infection	infection	NN
343	346	and	and	CC
347	358	eradication	eradication	NN
359	366	remains	remain	VBZ
367	370	for	for	IN
371	376	these	these	DT
377	384	viruses	virus	NNS
385	387	to	to	TO
388	399	proliferate	proliferate	VB
399	400	.	.	.

401	402	A	a	DT
403	406	few	few	JJ
407	414	viruses	virus	NNS
414	415	,	,	,
416	420	like	like	IN
421	424	the	the	DT
425	438	Herpesviruses	Herpesvirus	NNPS
439	441	or	or	CC
442	445	the	the	DT
446	462	papillomaviruses	papillomavirus	NNS
462	463	,	,	,
464	471	however	however	RB
471	472	,	,	,
473	477	have	have	VBP
478	487	developed	develop	VBN
488	489	a	a	DT
490	503	sophisticated	sophisticated	JJ
504	512	strategy	strategy	NN
513	516	for	for	IN
517	527	persisting	persist	VBG
528	536	lifelong	lifelong	NN
536	537	,	,	,
538	545	usually	usually	RB
546	562	asymptomatically	asymptomatically	RB
563	565	in	in	IN
566	569	the	the	DT
570	574	host	host	NN
574	575	,	,	,
576	582	hiding	hide	VBG
583	587	from	from	IN
588	591	the	the	DT
592	598	immune	immune	JJ
599	605	system	system	NN
606	609	and	and	CC
610	619	producing	produce	VBG
620	630	infectious	infectious	JJ
631	638	progeny	progeny	NN
639	641	at	at	IN
642	645	the	the	DT
646	650	same	same	JJ
651	655	time	time	NN
655	656	.	.	.

657	661	This	this	DT
662	670	strategy	strategy	NN
671	678	depends	depend	VBZ
679	681	on	on	IN
682	683	a	a	DT
684	694	separation	separation	NN
695	697	of	of	IN
698	705	latency	latency	NN
706	709	and	and	CC
710	713	the	the	DT
714	719	lytic	lytic	JJ
720	731	replication	replication	NN
731	732	,	,	,
733	739	either	either	CC
740	742	by	by	IN
743	747	time	time	NN
748	751	due	due	JJ
752	754	to	to	TO
755	780	differentiation-dependent	differentiation-dependent	JJ
781	791	mechanisms	mechanism	NNS
792	794	or	or	CC
795	797	by	by	IN
798	805	spatial	spatial	JJ
806	816	separation	separation	NN
817	819	as	as	IN
820	823	the	the	DT
824	830	result	result	NN
831	833	of	of	IN
834	843	different	different	JJ
844	848	host	host	NN
849	853	cell	cell	NN
854	859	types	type	NNS
859	860	.	.	.

861	865	Both	both	DT
866	869	are	be	VBP
870	874	true	true	JJ
875	878	for	for	IN
879	882	the	the	DT
883	895	Epstein-Barr	epstein-barr	JJ
896	901	virus	virus	NN
902	903	(	(	(
903	906	EBV	EBV	NNP
906	907	)	)	)
907	908	.	.	.

909	910	B	B	NNP
911	916	cells	cell	NNS
917	920	and	and	CC
921	931	epithelial	epithelial	JJ
932	937	cells	cell	NNS
938	942	have	have	VBP
943	944	a	a	DT
945	952	pivotal	pivotal	JJ
953	957	role	role	NN
958	960	in	in	IN
961	964	the	the	DT
965	969	life	life	NN
970	975	cycle	cycle	NN
976	978	of	of	IN
979	982	the	the	DT
983	988	virus	virus	NN
988	989	.	.	.

990	993	The	the	DT
994	1000	former	former	NN
1001	1004	can	can	MD
1005	1011	become	become	VB
1012	1020	latently	latently	RB
1021	1029	infected	infected	JJ
1030	1033	and	and	CC
1034	1037	are	be	VBP
1038	1045	thought	think	VBN
1046	1048	to	to	TO
1049	1051	be	be	VB
1052	1055	the	the	DT
1056	1061	virus	virus	NN
1062	1071	reservoir	reservoir	NN
1072	1074	in	in	FW
1075	1079	vivo	vivo	FW
1079	1080	,	,	,
1081	1088	whereas	whereas	IN
1089	1092	the	the	DT
1093	1099	latter	latter	JJ
1100	1104	were	be	VBD
1105	1110	shown	show	VBN
1111	1113	to	to	TO
1114	1116	be	be	VB
1117	1127	permissive	permissive	JJ
1128	1131	for	for	IN
1132	1137	lytic	lytic	JJ
1138	1149	replication	replication	NN
1149	1150	.	.	.

1151	1158	However	however	RB
1158	1159	,	,	,
1160	1171	replication	replication	NN
1172	1174	of	of	IN
1175	1178	EBV	EBV	NNP
1179	1181	in	in	FW
1182	1186	vivo	vivo	FW
1187	1189	is	be	VBZ
1190	1200	controlled	control	VBN
1201	1210	primarily	primarily	RB
1211	1213	by	by	IN
1214	1218	host	host	NN
1219	1225	immune	immune	JJ
1226	1236	mechanisms	mechanism	NNS
1237	1246	selecting	select	VBG
1247	1250	for	for	IN
1251	1256	cells	cell	NNS
1257	1261	that	that	WDT
1262	1265	are	be	VBP
1266	1269	not	not	RB
1270	1280	permissive	permissive	JJ
1281	1284	for	for	IN
1285	1290	viral	viral	JJ
1291	1302	replication	replication	NN
1303	1305	as	as	IN
1306	1309	the	the	DT
1310	1316	result	result	NN
1317	1319	of	of	IN
1320	1321	a	a	DT
1322	1332	particular	particular	JJ
1333	1336	set	set	NN
1337	1339	of	of	IN
1340	1353	transcription	transcription	NN
1354	1361	factors	factor	NNS
1361	1362	.	.	.

1363	1368	These	these	DT
1369	1376	factors	factor	NNS
1377	1384	control	control	VBP
1385	1388	the	the	DT
1389	1397	activity	activity	NN
1398	1400	of	of	IN
1401	1404	the	the	DT
1405	1415	regulatory	regulatory	JJ
1416	1431	immediate-early	immediate-early	JJ
1432	1437	genes	gene	NNS
1438	1441	and	and	CC
1441	1442	,	,	,
1443	1445	in	in	IN
1446	1454	addition	addition	NN
1454	1455	,	,	,
1456	1461	lytic	lytic	JJ
1462	1465	and	and	CC
1466	1472	latent	latent	JJ
1473	1478	cycle	cycle	NN
1479	1489	regulatory	regulatory	JJ
1490	1495	genes	gene	NNS
1496	1506	negatively	negatively	RB
1507	1516	interfere	interfere	VBP
1517	1521	with	with	IN
1522	1526	each	each	DT
1527	1532	other	other	JJ
1533	1536	and	and	CC
1537	1541	thus	thus	RB
1542	1546	link	link	VBP
1547	1555	cellular	cellular	JJ
1556	1559	and	and	CC
1560	1565	viral	viral	JJ
1566	1570	gene	gene	NN
1571	1581	regulatory	regulatory	JJ
1582	1592	mechanisms	mechanism	NNS
1592	1593	.	.	.

1594	1605	Disturbance	disturbance	NN
1606	1608	of	of	IN
1609	1613	both	both	CC
1614	1617	the	the	DT
1618	1624	immune	immune	JJ
1625	1637	surveillance	surveillance	NN
1638	1640	as	as	RB
1641	1645	well	well	RB
1646	1648	as	as	IN
1649	1654	viral	viral	JJ
1655	1659	gene	gene	NN
1660	1670	regulation	regulation	NN
1671	1674	may	may	MD
1675	1681	result	result	VB
1682	1684	in	in	IN
1685	1699	EBV-associated	ebv-associated	JJ
1700	1707	disease	disease	NN
1707	1708	.	.	.