0	10	Activation	Activation	NNP
11	13	of	of	IN
14	17	the	the	DT
18	23	human	human	JJ
24	36	delta-globin	delta-globin	NN
37	41	gene	gene	NN
42	50	promoter	promoter	NN
51	53	in	in	IN
54	61	primary	primary	JJ
62	67	adult	adult	JJ
68	77	erythroid	erythroid	JJ
78	83	cells	cell	NNS
83	84	.	.	.

86	97	Restoration	Restoration	NNP
98	100	of	of	IN
101	104	the	the	DT
105	110	CCAAT	CCAAT	NNP
111	114	box	box	NN
115	117	or	or	CC
118	127	insertion	insertion	NN
128	130	of	of	IN
131	133	an	an	DT
134	143	erythroid	erythroid	JJ
144	156	Kruppel-like	kruppel-like	JJ
157	163	factor	factor	NN
164	165	(	(	(
165	169	EKLF	EKLF	NNP
169	170	)	)	)
171	178	binding	binding	NN
179	183	site	site	NN
184	186	in	in	IN
187	190	the	the	DT
191	196	delta	delta	NN
197	205	promoter	promoter	NN
206	215	activates	activate	VBZ
216	219	its	its	PRP$
220	230	expression	expression	NN
231	233	in	in	IN
234	241	several	several	JJ
242	251	erythroid	erythroid	JJ
252	256	cell	cell	NN
257	262	lines	line	NNS
262	263	.	.	.

264	266	We	we	PRP
267	275	extended	extend	VBD
276	281	these	these	DT
282	289	studies	study	NNS
290	295	using	use	VBG
296	297	a	a	DT
298	303	novel	novel	JJ
304	311	primary	primary	JJ
312	317	human	human	JJ
318	323	adult	adult	JJ
324	333	erythroid	erythroid	JJ
334	338	cell	cell	NN
339	340	(	(	(
340	344	hAEC	haec	NN
344	345	)	)	)
346	352	system	system	NN
353	355	to	to	TO
356	367	investigate	investigate	VB
368	373	these	these	DT
374	381	effects	effect	NNS
382	384	at	at	IN
385	388	the	the	DT
389	393	late	late	JJ
394	406	erythroblast	erythroblast	NN
407	412	stage	stage	NN
412	413	.	.	.

414	425	Restoration	Restoration	NNP
426	428	of	of	IN
429	432	the	the	DT
433	438	CCAAT	ccaat	NN
439	442	box	box	NN
443	445	at	at	IN
446	449	-70	-70	CD
450	452	bp	bp	NN
452	453	,	,	,
454	456	or	or	CC
457	466	insertion	insertion	NN
467	469	of	of	IN
470	472	an	an	DT
473	477	EKLF	EKLF	NNP
478	485	binding	binding	NN
486	490	site	site	NN
491	493	at	at	IN
494	497	-85	-85	CD
498	500	bp	bp	NN
501	503	or	or	CC
504	507	-95	-95	CD
508	510	bp	bp	NN
511	513	in	in	IN
514	517	the	the	DT
518	526	promoter	promoter	NN
527	540	significantly	significantly	RB
541	550	increased	increase	VBD
551	556	delta	delta	NN
557	563	globin	globin	NN
564	568	gene	gene	NN
569	579	expression	expression	NN
580	582	in	in	IN
583	587	hAEC	haec	NN
587	588	.	.	.

589	592	Our	our	PRP$
593	600	results	result	NNS
601	612	demonstrate	demonstrate	VBP
613	617	that	that	IN
618	621	the	the	DT
622	629	altered	alter	VBN
630	635	CCAAT	ccaat	NN
636	639	box	box	NN
640	641	(	(	(
641	646	CCAAC	CCAAC	NNP
646	647	)	)	)
648	651	and	and	CC
652	655	the	the	DT
656	660	lack	lack	NN
661	663	of	of	IN
664	666	an	an	DT
667	671	EKLF	EKLF	NNP
672	679	binding	binding	NN
680	684	site	site	NN
685	687	in	in	IN
688	700	delta-globin	delta-globin	NN
701	711	contribute	contribute	VBP
712	714	to	to	TO
715	718	its	its	PRP$
719	722	low	low	JJ
723	728	level	level	NN
729	731	of	of	IN
732	742	expression	expression	NN
743	745	in	in	IN
746	749	the	the	DT
750	754	hAEC	haec	NN
755	760	model	model	NN
761	763	as	as	RB
764	768	well	well	RB
768	769	.	.	.