0 12 Interactions interaction NNS 13 20 between between IN 21 24 the the DT 25 30 class class NN 31 33 II ii CD 34 48 transactivator transactivator NN 49 52 and and CC 53 57 CREB CREB NNP 58 65 binding binding NN 66 73 protein protein NN 74 82 increase increase VBP 83 96 transcription transcription NN 97 99 of of IN 100 105 major major JJ 106 124 histocompatibility histocompatibility NN 125 132 complex complex NN 133 138 class class NN 139 141 II ii CD 142 147 genes gene NNS 147 148 . . . 150 155 Class Class NNP 156 158 II ii CD 159 164 major major JJ 165 183 histocompatibility histocompatibility NN 184 185 ( ( ( 185 190 class class NN 191 193 II ii CD 193 194 ) ) ) 195 200 genes gene NNS 201 204 are be VBP 205 214 regulated regulate VBN 215 217 in in IN 218 219 a a DT 220 235 B-cell-specific b-cell-specific JJ 236 239 and and CC 240 245 gamma gamma NN 246 266 interferon-inducible interferon-inducible JJ 267 274 fashion fashion NN 274 275 . . . 276 279 The the DT 280 286 master master NN 287 293 switch switch NN 294 297 for for IN 298 301 the the DT 302 312 expression expression NN 313 315 of of IN 316 321 these these DT 322 327 genes gene NNS 328 330 is be VBZ 331 334 the the DT 335 340 class class NN 341 343 II ii CD 344 358 transactivator transactivator NN 359 360 ( ( ( 360 365 CIITA CIITA NNP 365 366 ) ) ) 366 367 . . . 368 370 In in IN 371 375 this this DT 376 382 report report NN 382 383 , , , 384 386 we we PRP 387 398 demonstrate demonstrate VBP 399 403 that that IN 404 407 one one CD 408 410 of of IN 411 414 the the DT 415 424 functions function NNS 425 427 of of IN 428 433 CIITA CIITA NNP 434 436 is be VBZ 437 439 to to TO 440 447 recruit recruit VB 448 451 the the DT 452 456 CREB CREB NNP 457 464 binding binding NN 465 472 protein protein NN 473 474 ( ( ( 474 477 CBP CBP NNP 477 478 ) ) ) 479 481 to to TO 482 487 class class NN 488 490 II ii CD 491 500 promoters promoter NNS 500 501 . . . 502 505 Not not RB 506 510 only only RB 511 521 functional functional JJ 522 525 but but CC 526 530 also also RB 531 539 specific specific JJ 540 547 binding binding NN 548 560 interactions interaction NNS 561 568 between between IN 569 574 CIITA CIITA NNP 575 578 and and CC 579 582 CBP CBP NNP 583 587 were be VBD 588 600 demonstrated demonstrate VBN 600 601 . . . 602 610 Moreover moreover RB 610 611 , , , 612 613 a a DT 614 622 dominant dominant JJ 623 631 negative negative JJ 632 636 form form NN 637 639 of of IN 640 643 CBP CBP NNP 644 653 decreased decrease VBD 654 657 the the DT 658 666 activity activity NN 667 669 of of IN 670 675 class class NN 676 678 II ii CD 679 688 promoters promoter NNS 689 692 and and CC 693 699 levels level NNS 700 702 of of IN 703 708 class class NN 709 711 II ii CD 712 724 determinants determinant NNS 725 727 on on IN 728 731 the the DT 732 739 surface surface NN 740 742 of of IN 743 748 cells cell NNS 748 749 . . . 750 757 Finally finally RB 757 758 , , , 759 762 the the DT 763 773 inhibition inhibition NN 774 776 of of IN 777 782 class class NN 783 785 II ii CD 786 790 gene gene NN 791 801 expression expression NN 802 804 by by IN 805 808 the the DT 809 823 glucocorticoid glucocorticoid NN 824 831 hormone hormone NN 832 837 could could MD 838 840 be be VB 841 851 attributed attribute VBN 852 854 to to TO 855 858 the the DT 859 869 squelching squelching NN 870 872 of of IN 873 876 CBP CBP NNP 877 879 by by IN 880 883 the the DT 884 898 glucocorticoid glucocorticoid NN 899 907 receptor receptor NN 907 908 . . . 909 911 We we PRP 912 920 conclude conclude VBP 921 925 that that IN 926 929 CBP CBP NNP 929 930 , , , 931 932 a a DT 933 940 histone histone NN 941 958 acetyltransferase acetyltransferase NN 958 959 , , , 960 965 plays play VBZ 966 968 an an DT 969 978 important important JJ 979 983 role role NN 984 986 in in IN 987 990 the the DT 991 1004 transcription transcription NN 1005 1007 of of IN 1008 1013 class class NN 1014 1016 II ii CD 1017 1022 genes gene NNS 1022 1023 . . .