0 12 Phenylarsine Phenylarsine NNP 13 18 oxide oxide NN 19 27 inhibits inhibit VBZ 28 30 ex ex FW 31 35 vivo vivo FW 36 41 HIV-1 HIV-1 NNP 42 52 expression expression NN 52 53 . . . 55 67 Phenylarsine Phenylarsine NNP 68 73 oxide oxide NN 74 75 ( ( ( 75 78 PAO PAO NNP 78 79 ) ) ) 79 80 , , , 81 86 which which WDT 87 89 is be VBZ 90 99 described describe VBN 100 102 as as IN 103 105 an an DT 106 115 inhibitor inhibitor NN 116 118 of of IN 119 127 tyrosine tyrosine NN 128 139 phosphatase phosphatase NN 140 148 activity activity NN 148 149 , , , 150 158 inhibits inhibit VBZ 159 163 H2O2 h2o2 NN 164 171 release release NN 172 176 from from IN 177 182 human human JJ 183 193 peripheral peripheral JJ 194 199 blood blood NN 200 211 mononuclear mononuclear JJ 212 217 cells cell NNS 218 219 ( ( ( 219 224 PBMCs PBMC NNP 224 225 ) ) ) 226 228 as as IN 229 237 measured measure VBN 238 240 by by IN 241 257 electrochemistry electrochemistry NN 257 258 . . . 259 264 Since since IN 265 270 human human JJ 271 287 immunodeficiency immunodeficiency NN 288 293 virus virus NN 294 298 type type NN 299 300 1 1 CD 301 302 ( ( ( 302 307 HIV-1 HIV-1 NNP 307 308 ) ) ) 309 320 replication replication NN 321 323 is be VBZ 324 329 known know VBN 330 332 to to TO 333 335 be be VB 336 343 favored favor VBN 344 349 under under IN 350 359 oxidative oxidative JJ 360 366 stress stress NN 367 377 conditions condition NNS 377 378 , , , 379 381 ex ex FW 382 386 vivo vivo FW 387 398 experiments experiment NNS 399 404 using use VBG 405 415 uninfected uninfected JJ 416 421 PBMCs pbmc NNS 421 422 , , , 423 430 primary primary JJ 431 440 monocytes monocyte NNS 441 443 or or CC 444 445 a a DT 446 454 latently latently RB 455 463 infected infected JJ 464 476 promonocytic promonocytic JJ 477 479 U1 u1 NN 480 484 cell cell NN 485 489 line line NN 490 494 show show VBP 495 499 that that IN 500 505 HIV-1 HIV-1 NNP 506 517 replication replication NN 518 521 and and CC 522 534 reactivation reactivation NN 534 535 , , , 536 545 monitored monitor VBN 546 548 by by IN 549 552 p24 p24 NN 553 560 antigen antigen NN 561 572 measurement measurement NN 572 573 , , , 574 577 are be VBP 578 587 inhibited inhibit VBN 588 590 by by IN 591 594 PAO PAO NNP 595 597 in in IN 598 599 a a DT 600 605 time- time- NN 606 609 and and CC 610 633 concentration-dependent concentration-dependent JJ 634 640 manner manner NN 640 641 . . . 642 647 These these DT 648 660 observations observation NNS 661 664 can can MD 665 667 be be VB 668 674 linked link VBN 675 679 with with IN 680 683 the the DT 684 694 inhibition inhibition NN 695 697 of of IN 698 706 NF-kappa NF-kappa NNP 707 708 B B NNP 709 719 activation activation NN 720 724 when when WRB 725 735 uninfected uninfected JJ 736 745 monocytes monocyte NNS 746 749 are be VBP 750 757 induced induce VBN 758 760 by by IN 761 767 either either CC 768 773 tumor tumor NN 774 782 necrosis necrosis NN 783 789 factor factor NN 790 795 alpha alpha NN 796 797 ( ( ( 797 806 TNF-alpha TNF-alpha NNP 806 807 ) ) ) 808 815 phorbol phorbol NN 816 828 12-myristate 12-myristate NN 829 839 13-acetate 13-acetate NN 840 841 ( ( ( 841 844 PMA PMA NNP 844 845 ) ) ) 846 848 or or CC 849 867 lipopolysaccharide lipopolysaccharide NN 868 869 ( ( ( 869 872 LPS LPS NNP 872 873 ) ) ) 873 874 . . .