0 10 Regulation regulation NN 11 13 of of IN 14 24 fas-ligand fas-ligand NN 25 35 expression expression NN 36 42 during during IN 43 61 activation-induced activation-induced JJ 62 66 cell cell NN 67 72 death death NN 73 75 in in IN 76 77 T t NN 78 89 lymphocytes lymphocyte NNS 90 93 via via IN 94 101 nuclear nuclear JJ 102 108 factor factor NN 109 115 kappaB kappab NN 115 116 . . . 118 119 T t NN 120 124 cell cell NN 125 133 receptor receptor NN 134 144 engagement engagement NN 145 154 activates activate VBZ 155 168 transcription transcription NN 169 176 factors factor NNS 177 186 important important JJ 187 190 for for IN 191 199 cytokine cytokine NN 200 204 gene gene NN 205 215 regulation regulation NN 215 216 . . . 217 229 Additionally additionally RB 229 230 , , , 231 235 this this DT 236 245 signaling signaling NN 246 253 pathway pathway NN 254 258 also also RB 259 264 leads lead VBZ 265 267 to to TO 268 286 activation-induced activation-induced JJ 287 296 apoptosis apoptosis NN 297 299 in in IN 300 301 T t NN 302 313 lymphocytes lymphocyte NNS 314 318 that that WDT 319 321 is be VBZ 322 331 dependent dependent JJ 332 334 on on IN 335 339 FasL FasL NNP 340 353 transcription transcription NN 354 357 and and CC 358 368 expression expression NN 368 369 . . . 370 374 Here here RB 375 377 we we PRP 378 389 demonstrate demonstrate VBP 390 394 that that IN 395 402 nuclear nuclear JJ 403 409 factor factor NN 410 416 kappaB kappaB NNP 417 418 ( ( ( 418 427 NF-kappaB NF-kappaB NNP 427 428 ) ) ) 428 429 , , , 430 435 which which WDT 436 438 is be VBZ 439 447 involved involve VBN 448 450 in in IN 451 454 the the DT 455 470 transcriptional transcriptional JJ 471 481 regulation regulation NN 482 484 of of IN 485 489 many many JJ 490 498 cytokine cytokine NN 499 504 genes gene NNS 505 514 expressed express VBN 515 517 in in IN 518 527 activated activate VBN 528 539 lymphocytes lymphocyte NNS 539 540 , , , 541 545 also also RB 546 551 plays play VBZ 552 553 a a DT 554 558 role role NN 559 561 in in IN 562 563 T t NN 564 568 cell cell NN 569 587 activation-induced activation-induced JJ 588 592 FasL FasL NNP 593 603 expression expression NN 603 604 . . . 605 615 Inhibition Inhibition NNP 616 618 of of IN 619 628 NF-kappaB NF-kappaB NNP 629 637 activity activity NN 638 640 in in IN 641 642 a a DT 643 644 T t NN 645 649 cell cell NN 650 659 hybridoma hybridoma NN 660 665 leads lead VBZ 666 668 to to TO 669 678 decreased decrease VBN 679 683 FasL fasl NN 684 694 expression expression NN 695 698 and and CC 699 708 apoptosis apoptosis NN 709 713 upon upon IN 714 715 T t NN 716 720 cell cell NN 721 729 receptor receptor NN 730 741 stimulation stimulation NN 741 742 . . . 743 745 We we PRP 746 756 identified identify VBD 757 760 the the DT 761 770 NF-kappaB NF-kappaB NNP 771 775 site site NN 776 778 in in IN 779 782 the the DT 783 787 FasL FasL NNP 788 796 promoter promoter NN 797 801 that that WDT 802 813 contributes contribute VBZ 814 816 to to TO 817 821 such such JJ 822 832 regulation regulation NN 832 833 . . . 834 847 Co-expression Co-expression NNP 848 850 of of IN 851 854 p65 p65 NN 855 856 ( ( ( 856 859 Rel Rel NNP 860 861 A A NNP 861 862 ) ) ) 863 867 with with IN 868 871 the the DT 872 876 FasL FasL NNP 877 885 promoter promoter NN 886 894 enhanced enhance VBD 895 898 its its PRP$ 899 907 activity activity NN 907 908 , , , 909 912 and and CC 913 926 co-expression co-expression NN 927 929 of of IN 930 937 IkappaB IkappaB NNP 938 950 dramatically dramatically RB 951 960 inhibited inhibit VBD 961 964 the the DT 965 974 inducible inducible JJ 975 983 promoter promoter NN 984 992 activity activity NN 992 993 . . . 994 996 In in IN 997 1005 contrast contrast NN 1005 1006 , , , 1007 1010 the the DT 1011 1024 transcription transcription NN 1025 1031 factor factor NN 1032 1036 AP-1 ap-1 NN 1037 1039 is be VBZ 1040 1043 not not RB 1044 1052 required require VBN 1053 1056 for for IN 1057 1075 activation-induced activation-induced JJ 1076 1080 FasL FasL NNP 1081 1089 promoter promoter NN 1090 1098 activity activity NN 1098 1099 . . . 1100 1105 These these DT 1106 1113 results result NNS 1114 1120 define define VBP 1121 1122 a a DT 1123 1127 role role NN 1128 1131 for for IN 1132 1141 NF-kappaB NF-kappaB NNP 1142 1144 in in IN 1145 1154 mediating mediate VBG 1155 1159 FasL fasl NN 1160 1170 expression expression NN 1171 1177 during during IN 1178 1179 T t NN 1180 1184 cell cell NN 1185 1195 activation activation NN 1195 1196 . . .