0 12 Reactivation Reactivation NNP 13 15 of of IN 16 22 Kaposi Kaposi NNP 22 24 ’s 's POS 25 43 sarcoma-associated sarcoma-associated JJ 44 55 herpesvirus herpesvirus NN 56 65 infection infection NN 66 70 from from IN 71 78 latency latency NN 79 81 by by IN 82 92 expression expression NN 93 95 of of IN 96 99 the the DT 100 103 ORF ORF NNP 104 106 50 50 CD 107 121 transactivator transactivator NN 121 122 , , , 123 124 a a DT 125 132 homolog homolog NN 133 135 of of IN 136 139 the the DT 140 143 EBV EBV NNP 144 145 R r NN 146 153 protein protein NN 153 154 . . . 156 162 Kaposi Kaposi NNP 162 164 ’s 's POS 165 172 sarcoma sarcoma NN 173 174 ( ( ( 174 188 KS)-associated ks)-associated JJ 189 200 herpesvirus herpesvirus NN 201 202 ( ( ( 202 206 KSHV KSHV NNP 206 207 ) ) ) 207 208 , , , 209 211 or or CC 212 217 human human JJ 218 229 herpesvirus herpesvirus NN 230 231 8 8 CD 231 232 , , , 233 235 is be VBZ 236 237 a a DT 238 250 lymphotropic lymphotropic JJ 251 256 virus virus NN 257 265 strongly strongly RB 266 272 linked link VBN 273 275 to to TO 276 283 several several JJ 284 296 AIDS-related aids-related JJ 297 306 neoplasms neoplasm NNS 306 307 . . . 308 311 The the DT 312 319 primary primary JJ 320 329 reservoir reservoir NN 330 332 of of IN 333 342 infection infection NN 343 351 consists consist VBZ 352 354 of of IN 355 363 latently latently RB 364 372 infected infected JJ 373 374 B B NNP 375 386 lymphocytes lymphocyte NNS 387 390 and and CC 391 399 possibly possibly RB 400 405 other other JJ 406 417 mononuclear mononuclear JJ 418 423 cells cell NNS 423 424 . . . 425 430 Viral viral JJ 431 443 reactivation reactivation NN 444 448 from from IN 449 456 latency latency NN 457 460 and and CC 461 467 spread spread NN 468 472 from from IN 473 477 this this DT 478 486 lymphoid lymphoid JJ 487 496 reservoir reservoir NN 497 499 is be VBZ 500 510 presumably presumably RB 511 519 required require VBN 520 523 for for IN 524 535 development development NN 536 538 of of IN 539 550 nonlymphoid nonlymphoid JJ 551 557 tumors tumor NNS 558 562 like like IN 563 565 KS ks NN 565 566 . . . 567 571 Here here RB 572 574 we we PRP 575 579 show show VBP 580 584 that that IN 585 596 deregulated deregulate VBN 597 607 expression expression NN 608 610 of of IN 611 612 a a DT 613 619 single single JJ 620 625 viral viral JJ 626 630 gene gene NN 630 631 , , , 632 635 ORF ORF NNP 636 638 50 50 CD 638 639 , , , 640 645 which which WDT 646 653 encodes encode VBZ 654 655 a a DT 656 670 transactivator transactivator NN 671 675 able able JJ 676 678 to to TO 679 690 selectively selectively RB 691 701 upregulate upregulate VB 702 715 delayed-early delayed-early JJ 716 721 viral viral JJ 722 727 genes gene NNS 727 728 , , , 729 737 suffices suffice NNS 738 740 to to TO 741 748 disrupt disrupt VB 749 756 latency latency NN 757 760 and and CC 761 767 induce induce VB 768 771 the the DT 772 777 lytic lytic JJ 778 782 gene gene NN 783 790 cascade cascade NN 791 793 in in IN 794 802 latently latently RB 803 811 infected infected JJ 812 813 B B NNP 814 819 cells cell NNS 819 820 . . . 821 824 The the DT 825 839 identification identification NN 840 842 of of IN 843 847 this this DT 848 852 gene gene NN 853 858 opens open VBZ 859 862 the the DT 863 866 way way NN 867 869 to to TO 870 877 studies study NNS 878 880 of of IN 881 884 the the DT 885 896 physiologic physiologic JJ 897 907 mechanisms mechanism NNS 908 919 controlling control VBG 920 931 reactvation reactvation NN 932 934 of of IN 935 939 KSHV KSHV NNP 940 944 from from IN 945 952 latency latency NN 952 953 . . . 954 963 Copyright Copyright NNP 964 968 1998 1998 CD 969 977 Academic Academic NNP 978 983 Press Press NNP 983 984 . . .