0	5	Human	human	JJ
6	12	T-cell	T-cell	NNP
13	21	leukemia	leukemia	NN
22	27	virus	virus	NN
28	32	type	type	NN
33	34	1	1	CD
35	38	tax	tax	NN
39	46	protein	protein	NN
47	56	abrogates	abrogate	VBZ
57	70	interleukin-2	interleukin-2	NN
71	81	dependence	dependence	NN
82	84	in	in	IN
85	86	a	a	DT
87	92	mouse	mouse	NN
93	99	T-cell	t-cell	NN
100	104	line	line	NN
104	105	.	.	.

107	112	Human	human	JJ
113	119	T-cell	T-cell	NNP
120	128	leukemia	leukemia	NN
129	134	virus	virus	NN
135	139	type	type	NN
140	141	1	1	CD
142	143	(	(	(
143	149	HTLV-1	htlv-1	NN
149	150	)	)	)
151	153	is	be	VBZ
154	157	the	the	DT
158	167	etiologic	etiologic	JJ
168	173	agent	agent	NN
174	176	of	of	IN
177	182	adult	adult	JJ
183	189	T-cell	t-cell	NN
190	198	leukemia	leukemia	NN
198	199	.	.	.

200	203	Tax	Tax	NNP
203	204	,	,	,
205	208	the	the	DT
209	214	viral	viral	JJ
215	222	protein	protein	NN
222	223	,	,	,
224	226	is	be	VBZ
227	234	thought	think	VBN
235	237	to	to	TO
238	240	be	be	VB
241	248	crucial	crucial	JJ
249	251	in	in	IN
252	255	the	the	DT
256	267	development	development	NN
268	270	of	of	IN
271	274	the	the	DT
275	282	disease	disease	NN
282	283	,	,	,
284	289	since	since	IN
290	292	it	it	PRP
293	303	transforms	transform	VBZ
304	311	healthy	healthy	JJ
312	313	T	t	NN
314	319	cells	cell	NNS
320	322	in	in	FW
323	328	vitro	vitro	FW
329	332	and	and	CC
333	340	induces	induce	VBZ
341	347	tumors	tumor	NNS
348	350	in	in	IN
351	361	transgenic	transgenic	JJ
362	369	animals	animal	NNS
369	370	.	.	.

371	373	We	we	PRP
374	382	examined	examine	VBD
383	386	the	the	DT
387	393	effect	effect	NN
394	396	of	of	IN
397	400	Tax	Tax	NNP
401	409	activity	activity	NN
410	412	on	on	IN
413	416	the	the	DT
417	423	growth	growth	NN
424	426	of	of	IN
427	430	the	the	DT
431	444	interleukin-2	interleukin-2	NN
445	446	(	(	(
446	461	IL-2)-dependent	il-2)-dependent	JJ
462	468	T-cell	T-cell	NNP
469	473	line	line	NN
474	480	CTLL-2	ctll-2	NN
480	481	.	.	.

482	488	Stable	stable	JJ
489	499	expression	expression	NN
500	502	of	of	IN
503	506	Tax	Tax	NNP
507	509	in	in	IN
510	516	CTLL-2	ctll-2	NN
517	528	transformed	transform	VBD
529	533	cell	cell	NN
534	540	growth	growth	NN
541	545	from	from	IN
546	551	being	be	VBG
552	556	IL-2	il-2	NN
557	566	dependent	dependent	JJ
567	569	to	to	TO
570	574	IL-2	il-2	NN
575	586	independent	independent	JJ
586	587	.	.	.

588	591	Tax	Tax	NNP
592	602	stimulated	stimulate	VBD
603	616	transcription	transcription	NN
617	624	through	through	IN
625	634	NF-kappaB	NF-kappaB	NNP
635	638	and	and	CC
639	642	the	the	DT
643	649	cyclic	cyclic	JJ
650	664	AMP-responsive	amp-responsive	JJ
665	677	element-like	element-like	JJ
678	686	sequence	sequence	NN
687	689	in	in	IN
690	693	the	the	DT
694	700	HTLV-1	htlv-1	NN
701	709	promoter	promoter	NN
709	710	.	.	.

711	714	The	the	DT
715	722	finding	finding	NN
723	725	of	of	IN
726	729	Tax	Tax	NNP
730	737	mutants	mutant	NNS
738	749	segregating	segregate	VBG
750	755	these	these	DT
756	759	two	two	CD
760	768	pathways	pathway	NNS
769	778	suggested	suggest	VBD
779	783	that	that	IN
784	787	the	the	DT
788	797	NF-kappaB	NF-kappaB	NNP
798	805	pathway	pathway	NN
806	809	was	be	VBD
810	819	essential	essential	JJ
820	823	for	for	IN
824	840	IL-2-independent	il-2-independent	JJ
841	847	growth	growth	NN
848	850	of	of	IN
851	857	CTLL-2	ctll-2	NN
858	863	cells	cell	NNS
864	869	while	while	IN
870	873	the	the	DT
874	877	CRE	CRE	NNP
878	885	pathway	pathway	NN
886	889	was	be	VBD
890	901	unnecessary	unnecessary	JJ
901	902	.	.	.

903	910	However	however	RB
910	911	,	,	,
912	916	both	both	DT
917	925	pathways	pathway	NNS
926	930	were	be	VBD
931	940	necessary	necessary	JJ
941	944	for	for	IN
945	952	another	another	DT
953	975	transformation-related	transformation-related	JJ
976	984	activity	activity	NN
985	986	(	(	(
986	992	colony	colony	NN
993	1002	formation	formation	NN
1003	1005	in	in	IN
1006	1010	soft	soft	JJ
1011	1015	agar	agar	NN
1015	1016	)	)	)
1017	1019	of	of	IN
1020	1030	CTLL-2/Tax	CTLL-2/Tax	NNP
1030	1031	.	.	.

1032	1035	Our	our	PRP$
1036	1043	results	result	NNS
1044	1048	show	show	VBP
1049	1053	that	that	IN
1054	1057	Tax	Tax	NNP
1058	1061	has	have	VBZ
1062	1064	at	at	IN
1065	1070	least	least	JJS
1071	1074	two	two	CD
1075	1083	distinct	distinct	JJ
1084	1094	activities	activity	NNS
1095	1097	on	on	IN
1098	1099	T	t	NN
1100	1105	cells	cell	NNS
1105	1106	,	,	,
1107	1110	and	and	CC
1111	1118	suggest	suggest	VBP
1119	1123	that	that	IN
1124	1127	Tax	Tax	NNP
1128	1133	plays	play	VBZ
1134	1135	a	a	DT
1136	1143	crucial	crucial	JJ
1144	1148	role	role	NN
1149	1151	in	in	IN
1152	1168	IL-2-independent	il-2-independent	JJ
1169	1175	T-cell	T-cell	NNP
1176	1190	transformation	transformation	NN
1191	1198	induced	induce	VBN
1199	1201	by	by	IN
1202	1208	HTLV-1	HTLV-1	NNP
1208	1209	,	,	,
1210	1212	in	in	IN
1213	1221	addition	addition	NN
1222	1224	to	to	TO
1225	1228	its	its	PRP$
1229	1239	well-known	well-known	JJ
1240	1254	IL-2-dependent	il-2-dependent	JJ
1255	1259	cell	cell	NN
1260	1274	transformation	transformation	NN
1274	1275	.	.	.