0	28	Anoxia/reoxygenation-induced	anoxia/reoxygenation-induced	JJ
29	38	tolerance	tolerance	NN
39	43	with	with	IN
44	51	respect	respect	NN
52	54	to	to	TO
55	72	polymorphonuclear	polymorphonuclear	JJ
73	82	leukocyte	leukocyte	NN
83	91	adhesion	adhesion	NN
92	94	to	to	TO
95	103	cultured	culture	VBN
104	115	endothelial	endothelial	JJ
116	121	cells	cell	NNS
121	122	.	.	.

123	124	A	a	DT
125	132	nuclear	nuclear	JJ
133	155	factor-kappaB-mediated	factor-kappab-mediated	JJ
156	166	phenomenon	phenomenon	NN
166	167	.	.	.

169	177	Exposing	expose	VBG
178	183	human	human	JJ
184	193	umbilical	umbilical	JJ
194	198	vein	vein	NN
199	210	endothelial	endothelial	JJ
211	216	cells	cell	NNS
217	218	(	(	(
218	224	HUVECs	HUVEC	NNP
224	225	)	)	)
226	228	to	to	TO
229	249	anoxia/reoxygenation	anoxia/reoxygenation	NN
250	251	(	(	(
251	254	A/R	A/R	NNP
254	255	)	)	)
256	263	results	result	VBZ
264	266	in	in	IN
267	269	an	an	DT
270	278	increase	increase	NN
279	281	in	in	IN
282	299	polymorphonuclear	polymorphonuclear	JJ
300	309	leukocyte	leukocyte	NN
310	311	(	(	(
311	314	PMN	PMN	NNP
314	315	)	)	)
316	324	adhesion	adhesion	NN
325	327	to	to	TO
328	334	HUVECs	huvec	NNS
334	335	.	.	.

336	340	This	this	DT
341	352	A/R-induced	a/r-induced	JJ
353	366	hyperadhesion	hyperadhesion	NN
367	369	is	be	VBZ
370	380	completely	completely	RB
381	390	prevented	prevent	VBN
391	393	by	by	IN
394	395	a	a	DT
396	404	previous	previous	JJ
405	406	(	(	(
406	408	24	24	CD
409	414	hours	hour	NNS
415	422	earlier	earlier	RBR
422	423	)	)	)
424	432	exposure	exposure	NN
433	435	of	of	IN
436	442	HUVECs	huvec	NNS
443	445	to	to	TO
446	449	A/R	A/R	NNP
449	450	.	.	.

451	455	This	this	DT
456	466	phenomenon	phenomenon	NN
467	470	has	have	VBZ
471	475	been	be	VBN
476	482	termed	term	VBN
483	484	“	``	``
484	487	A/R	a/r	NN
488	497	tolerance	tolerance	NN
497	498	.	.	.
498	499	”	''	''

500	508	Exposing	expose	VBG
509	515	HUVECs	huvec	NNS
516	518	to	to	TO
519	522	A/R	A/R	NNP
523	530	induces	induce	VBZ
531	533	an	an	DT
534	542	increase	increase	NN
543	545	in	in	IN
546	553	nuclear	nuclear	JJ
554	560	factor	factor	NN
561	567	kappaB	kappaB	NNP
568	569	(	(	(
569	578	NF-kappaB	NF-kappaB	NNP
578	579	)	)	)
580	582	in	in	IN
583	588	HUVEC	HUVEC	NNP
589	595	nuclei	nucleus	NNS
596	602	within	within	IN
603	604	4	4	CD
605	610	hours	hour	NNS
610	611	.	.	.

612	623	Interfering	interfere	VBG
624	628	with	with	IN
629	635	either	either	CC
636	645	NF-kappaB	NF-kappaB	NNP
646	656	activation	activation	NN
657	658	(	(	(
658	668	proteasome	proteasome	NN
669	678	inhibitor	inhibitor	NN
678	679	)	)	)
680	682	or	or	CC
683	696	translocation	translocation	NN
697	698	(	(	(
698	713	double-stranded	double-stranded	JJ
714	730	oligonucleotides	oligonucleotide	NNS
731	741	containing	contain	VBG
742	751	NF-kappaB	NF-kappaB	NNP
752	759	binding	binding	NN
760	768	sequence	sequence	NN
768	769	)	)	)
770	778	prevents	prevent	VBZ
779	782	the	the	DT
783	794	development	development	NN
795	797	of	of	IN
798	801	A/R	A/R	NNP
802	811	tolerance	tolerance	NN
812	813	(	(	(
813	815	ie	ie	FW
815	816	,	,	,
817	820	the	the	DT
821	829	increase	increase	NN
830	832	in	in	IN
833	844	A/R-induced	a/r-induced	JJ
845	848	PMN	PMN	NNP
849	857	adhesion	adhesion	NN
858	860	to	to	TO
861	867	HUVECs	HUVEC	NNP
868	870	is	be	VBZ
871	874	the	the	DT
875	879	same	same	JJ
880	885	after	after	IN
886	889	the	the	DT
890	895	first	first	JJ
896	899	and	and	CC
900	906	second	second	JJ
907	910	A/R	a/r	NN
911	921	challenges	challenge	NNS
921	922	)	)	)
922	923	.	.	.

924	926	NO	no	NN
927	937	production	production	NN
938	940	by	by	IN
941	947	HUVECs	HUVEC	NNP
948	950	is	be	VBZ
951	960	increased	increase	VBN
961	966	after	after	IN
967	970	the	the	DT
971	977	second	second	JJ
978	981	A/R	a/r	NN
982	991	challenge	challenge	NN
991	992	,	,	,
993	996	but	but	CC
997	1000	not	not	RB
1001	1006	after	after	IN
1007	1010	the	the	DT
1011	1016	first	first	JJ
1017	1020	A/R	a/r	NN
1021	1030	challenge	challenge	NN
1030	1031	.	.	.

1032	1042	Inhibition	Inhibition	NNP
1043	1045	of	of	IN
1046	1048	NO	no	NN
1049	1057	synthase	synthase	NN
1058	1059	(	(	(
1059	1062	NOS	nos	NN
1062	1063	)	)	)
1064	1070	during	during	IN
1071	1074	the	the	DT
1075	1081	second	second	JJ
1082	1085	A/R	a/r	NN
1086	1095	challenge	challenge	NN
1096	1104	prevents	prevent	VBZ
1105	1108	the	the	DT
1109	1120	development	development	NN
1121	1123	of	of	IN
1124	1127	A/R	A/R	NNP
1128	1137	tolerance	tolerance	NN
1138	1142	with	with	IN
1143	1150	respect	respect	NN
1151	1153	to	to	TO
1154	1157	PMN	pmn	NN
1158	1166	adhesion	adhesion	NN
1166	1167	.	.	.

1168	1175	However	however	RB
1175	1176	,	,	,
1177	1182	while	while	IN
1183	1189	HUVECs	HUVEC	NNP
1190	1199	contained	contain	VBD
1200	1211	endothelial	endothelial	JJ
1212	1215	NOS	nos	NN
1216	1223	protein	protein	NN
1223	1224	,	,	,
1225	1227	no	no	DT
1228	1237	inducible	inducible	JJ
1238	1241	NOS	nos	NN
1242	1245	was	be	VBD
1246	1254	detected	detect	VBN
1255	1257	in	in	IN
1258	1264	either	either	CC
1265	1273	tolerant	tolerant	JJ
1274	1276	or	or	CC
1277	1288	nontolerant	nontolerant	JJ
1289	1294	cells	cell	NNS
1294	1295	.	.	.

1296	1303	Further	further	JJ
1304	1311	studies	study	NNS
1312	1321	indicated	indicate	VBD
1322	1326	that	that	IN
1327	1337	inhibition	inhibition	NN
1338	1340	of	of	IN
1341	1359	GTP-cyclohydrolase	GTP-cyclohydrolase	NNP
1360	1361	I	i	CD
1362	1363	(	(	(
1363	1365	an	an	DT
1366	1372	enzyme	enzyme	NN
1373	1381	involved	involve	VBN
1382	1384	in	in	IN
1385	1387	de	de	FW
1388	1392	novo	novo	FW
1393	1402	synthesis	synthesis	NN
1403	1405	of	of	IN
1406	1408	an	an	DT
1409	1418	important	important	JJ
1419	1427	cofactor	cofactor	NN
1428	1431	for	for	IN
1432	1435	NOS	NOS	NNP
1436	1444	activity	activity	NN
1444	1445	,	,	,
1446	1465	tetrahydrobiopterin	tetrahydrobiopterin	NN
1465	1466	)	)	)
1467	1476	prevented	prevent	VBD
1477	1480	the	the	DT
1481	1491	generation	generation	NN
1492	1494	of	of	IN
1495	1497	NO	no	NN
1498	1500	in	in	IN
1501	1513	A/R-tolerant	a/r-tolerant	JJ
1514	1519	cells	cell	NNS
1519	1520	.	.	.

1521	1534	Extracellular	extracellular	JJ
1535	1545	generation	generation	NN
1546	1548	of	of	IN
1549	1551	NO	no	NN
1552	1553	(	(	(
1553	1555	NO	no	NN
1556	1561	donor	donor	NN
1561	1562	)	)	)
1563	1566	did	do	VBD
1567	1570	not	not	RB
1571	1577	effect	effect	VB
1578	1581	the	the	DT
1582	1595	hyperadhesion	hyperadhesion	NN
1596	1604	response	response	NN
1605	1612	induced	induce	VBN
1613	1615	by	by	IN
1616	1619	the	the	DT
1620	1627	initial	initial	JJ
1628	1631	A/R	a/r	NN
1632	1641	challenge	challenge	NN
1641	1642	.	.	.

1643	1646	A/R	A/R	NNP
1647	1651	also	also	RB
1652	1659	induced	induce	VBD
1660	1662	an	an	DT
1663	1670	oxidant	oxidant	JJ
1671	1677	stress	stress	NN
1678	1680	in	in	IN
1681	1686	naive	naive	JJ
1687	1693	HUVECs	huvec	NNS
1693	1694	,	,	,
1695	1698	but	but	CC
1699	1702	not	not	RB
1703	1705	in	in	IN
1706	1718	A/R-tolerant	a/r-tolerant	JJ
1719	1725	HUVECs	HUVEC	NNP
1725	1726	.	.	.

1727	1737	Inhibition	Inhibition	NNP
1738	1740	of	of	IN
1741	1744	NOS	NOS	NNP
1745	1751	during	during	IN
1752	1755	the	the	DT
1756	1762	second	second	JJ
1763	1766	A/R	a/r	NN
1767	1773	insult	insult	NN
1774	1781	results	result	VBZ
1782	1784	in	in	IN
1785	1788	the	the	DT
1789	1799	generation	generation	NN
1800	1802	of	of	IN
1803	1805	an	an	DT
1806	1813	oxidant	oxidant	JJ
1814	1820	stress	stress	NN
1821	1828	similar	similar	JJ
1829	1831	to	to	TO
1832	1836	that	that	DT
1837	1845	observed	observe	VBN
1846	1851	after	after	IN
1852	1855	the	the	DT
1856	1861	first	first	JJ
1862	1865	A/R	a/r	NN
1866	1875	challenge	challenge	NN
1875	1876	.	.	.

1877	1882	Taken	take	VBN
1883	1891	together	together	RB
1891	1892	,	,	,
1893	1896	the	the	DT
1897	1905	findings	finding	NNS
1906	1908	of	of	IN
1909	1912	the	the	DT
1913	1920	present	present	JJ
1921	1926	study	study	NN
1927	1930	are	be	VBP
1931	1941	consistent	consistent	JJ
1942	1946	with	with	IN
1947	1948	a	a	DT
1949	1953	role	role	NN
1954	1957	for	for	IN
1958	1967	NF-kappaB	NF-kappaB	NNP
1968	1970	in	in	IN
1971	1974	the	the	DT
1975	1986	development	development	NN
1987	1989	of	of	IN
1990	1993	A/R	A/R	NNP
1994	2003	tolerance	tolerance	NN
2004	2005	(	(	(
2005	2009	with	with	IN
2010	2017	respect	respect	NN
2018	2020	to	to	TO
2021	2024	PMN	pmn	NN
2025	2033	adhesion	adhesion	NN
2033	2034	)	)	)
2034	2035	,	,	,
2036	2043	perhaps	perhaps	RB
2044	2046	by	by	IN
2047	2062	transcriptional	transcriptional	JJ
2063	2073	regulation	regulation	NN
2074	2076	of	of	IN
2077	2095	GTP-cyclohydrolase	GTP-cyclohydrolase	NNP
2095	2096	.	.	.

2097	2100	The	the	DT
2101	2110	increased	increase	VBN
2111	2113	NO	no	NN
2114	2124	production	production	NN
2125	2131	during	during	IN
2132	2135	the	the	DT
2136	2142	second	second	JJ
2143	2146	A/R	a/r	NN
2147	2153	insult	insult	NN
2154	2161	reduces	reduce	VBZ
2162	2165	PMN	pmn	NN
2166	2174	adhesion	adhesion	NN
2175	2179	most	most	RBS
2180	2186	likely	likely	RB
2187	2189	by	by	IN
2190	2198	reducing	reduce	VBG
2199	2202	the	the	DT
2203	2216	intracellular	intracellular	JJ
2217	2224	oxidant	oxidant	JJ
2225	2231	stress	stress	NN
2232	2239	induced	induce	VBN
2240	2242	by	by	IN
2243	2246	A/R	A/R	NNP
2246	2247	.	.	.