0	10	Inhibition	Inhibition	NNP
11	13	of	of	IN
14	22	NF-kappa	NF-kappa	NNP
23	24	B	B	NNP
25	35	activation	activation	NN
36	38	in	in	FW
39	44	vitro	vitro	FW
45	48	and	and	CC
49	51	in	in	FW
52	56	vivo	vivo	FW
56	57	:	:	:
58	62	role	role	NN
63	65	of	of	IN
66	69	26S	26s	NN
70	80	proteasome	proteasome	NN
80	81	.	.	.

83	85	It	it	PRP
86	88	is	be	VBZ
89	97	becoming	become	VBG
98	110	increasingly	increasingly	RB
111	119	apparent	apparent	JJ
120	124	that	that	IN
125	133	NF-kappa	NF-kappa	NNP
134	135	B	B	NNP
136	141	plays	play	VBZ
142	143	a	a	DT
144	152	critical	critical	JJ
153	157	role	role	NN
158	160	in	in	IN
161	171	regulating	regulate	VBG
172	175	the	the	DT
176	188	inflammatory	inflammatory	JJ
189	197	response	response	NN
197	198	.	.	.

199	203	Data	Datum	NNP
204	212	obtained	obtain	VBN
213	217	from	from	IN
218	225	studies	study	NNS
226	228	in	in	IN
229	232	our	our	PRP$
233	245	laboratories	laboratory	NNS
246	257	demonstrate	demonstrate	VBP
258	262	that	that	IN
263	266	the	the	DT
267	277	proteasome	proteasome	NN
278	283	plays	play	VBZ
284	286	an	an	DT
287	296	important	important	JJ
297	301	role	role	NN
302	304	in	in	IN
305	308	the	the	DT
309	321	inflammatory	inflammatory	JJ
322	329	cascade	cascade	NN
330	332	by	by	IN
333	343	regulating	regulate	VBG
344	347	the	the	DT
348	358	activation	activation	NN
359	361	of	of	IN
362	370	NF-kappa	NF-kappa	NNP
371	373	B.	B.	NNP
374	380	Indeed	indeed	RB
380	381	,	,	,
382	385	the	the	DT
386	398	availability	availability	NN
399	401	of	of	IN
402	411	selective	selective	JJ
412	415	and	and	CC
416	422	orally	orally	RB
423	429	active	active	JJ
430	440	proteasome	proteasome	NN
441	451	inhibitors	inhibitor	NNS
452	458	should	should	MD
459	464	prove	prove	VB
465	471	useful	useful	JJ
472	474	in	in	IN
475	486	delineating	delineate	VBG
487	490	the	the	DT
491	496	roles	role	NNS
497	499	of	of	IN
500	503	the	the	DT
504	514	proteasome	proteasome	NN
515	518	and	and	CC
519	527	NF-kappa	NF-kappa	NNP
528	529	B	B	NNP
530	532	in	in	IN
533	538	other	other	JJ
539	557	pathophysiological	pathophysiological	JJ
558	568	conditions	condition	NNS
569	573	such	such	JJ
574	576	as	as	IN
577	583	cancer	cancer	NN
584	587	and	and	CC
588	593	heart	heart	NN
594	601	disease	disease	NN
601	602	.	.	.