# newdoc id = events.txt
# newpar
# sent_id = 1
# text = Decreased IL-12 production and Th1 cell development by acetyl salicylic acid-mediated inhibition of NF-kappaB.
1	Decreased	Decrease	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
2	IL	Il	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
3	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
4	12	12	NUM	CD	NumType=Card	_	_	_	_
5	production	production	NOUN	NN	Number=Sing	_	_	_	_
6	and	and	CCONJ	CC	_	_	_	_	_
7	Th1	th1	NUM	CD	NumType=Card	_	_	_	_
8	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
9	development	development	NOUN	NN	Number=Sing	_	_	_	_
10	by	by	ADP	IN	_	_	_	_	_
11	acetyl	acetyl	ADJ	JJ	Degree=Pos	_	_	_	_
12	salicylic	salicylic	ADJ	JJ	Degree=Pos	_	_	_	_
13	acid	acid	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
14	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
15	mediated	mediate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
16	inhibition	inhibition	NOUN	NN	Number=Sing	_	_	_	_
17	of	of	ADP	IN	_	_	_	_	_
18	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
19	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
20	kappaB	kappaB	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
21	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 2
# text = IL-12 is a 75-kDa heterodimeric cytokine composed of two covalently linked p35 and p40 chains.
1	IL	Il	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
2	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
3	12	12	NUM	CD	NumType=Card	_	_	_	_
4	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
5	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
6	75	75	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
7	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
8	kDa	kDa	NOUN	NN	Number=Sing	_	_	_	_
9	heterodimeric	heterodimeric	ADJ	JJ	Degree=Pos	_	_	_	_
10	cytokine	cytokine	NOUN	NN	Number=Sing	_	_	_	_
11	composed	compose	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
12	of	of	ADP	IN	_	_	_	_	_
13	two	two	NUM	CD	NumType=Card	_	_	_	_
14	covalently	covalently	ADV	RB	_	_	_	_	_
15	linked	link	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
16	p35	p35	NUM	CD	NumType=Card	_	_	_	_
17	and	and	CCONJ	CC	_	_	_	_	_
18	p40	p40	NUM	CD	NumType=Card	_	_	_	_
19	chains	chain	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
20	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3
# text = This pro-inflammatory cytokine plays a prominent role in the development of Th1 cell-mediated immune responses.
1	This	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
2	pro-inflammatory	pro-inflammatory	ADJ	JJ	Degree=Pos	_	_	_	_
3	cytokine	cytokine	NOUN	NN	Number=Sing	_	_	_	_
4	plays	play	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
5	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
6	prominent	prominent	ADJ	JJ	Degree=Pos	_	_	_	_
7	role	role	NOUN	NN	Number=Sing	_	_	_	_
8	in	in	ADP	IN	_	_	_	_	_
9	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
10	development	development	NOUN	NN	Number=Sing	_	_	_	_
11	of	of	ADP	IN	_	_	_	_	_
12	Th1	Th1	NUM	CD	NumType=Card	_	_	_	_
13	cell	cell	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
14	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
15	mediated	mediate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
16	immune	immune	ADJ	JJ	Degree=Pos	_	_	_	_
17	responses	response	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
18	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 4
# text = Th1 cell-mediated immune responses have been implicated in the pathogenesis of chronic inflammatory autoimmune diseases.
1	Th1	Th1	NUM	CD	NumType=Card	_	_	_	_
2	cell	cell	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
3	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
4	mediated	mediate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
5	immune	immune	ADJ	JJ	Degree=Pos	_	_	_	_
6	responses	response	NOUN	NNS	Number=Plur	_	_	_	_
7	have	have	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
8	been	be	AUX	VBN	Tense=Past|VerbForm=Part	_	_	_	_
9	implicated	implicate	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
10	in	in	ADP	IN	_	_	_	_	_
11	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
12	pathogenesis	pathogenesis	NOUN	NN	Number=Sing	_	_	_	_
13	of	of	ADP	IN	_	_	_	_	_
14	chronic	chronic	ADJ	JJ	Degree=Pos	_	_	_	_
15	inflammatory	inflammatory	ADJ	JJ	Degree=Pos	_	_	_	_
16	autoimmune	autoimmune	NOUN	NN	Number=Sing	_	_	_	_
17	diseases	disease	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
18	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 5
# text = Thus, IL-12 appears to be a critical factor in the generation and maintenance of chronic inflammatory conditions.
1	Thus	thus	ADV	RB	_	_	_	_	SpaceAfter=No
2	,	,	PUNCT	,	_	_	_	_	_
3	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
4	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
5	12	12	NUM	CD	NumType=Card	_	_	_	_
6	appears	appear	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
7	to	to	PART	TO	_	_	_	_	_
8	be	be	AUX	VB	VerbForm=Inf	_	_	_	_
9	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
10	critical	critical	ADJ	JJ	Degree=Pos	_	_	_	_
11	factor	factor	NOUN	NN	Number=Sing	_	_	_	_
12	in	in	ADP	IN	_	_	_	_	_
13	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
14	generation	generation	NOUN	NN	Number=Sing	_	_	_	_
15	and	and	CCONJ	CC	_	_	_	_	_
16	maintenance	maintenance	NOUN	NN	Number=Sing	_	_	_	_
17	of	of	ADP	IN	_	_	_	_	_
18	chronic	chronic	ADJ	JJ	Degree=Pos	_	_	_	_
19	inflammatory	inflammatory	ADJ	JJ	Degree=Pos	_	_	_	_
20	conditions	condition	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
21	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 6
# text = In this study, we investigated the effects of a commonly prescribed anti-inflammatory drug, acetyl salicylic acid (ASA), on IL-12 production and Th1 cell development.
1	In	in	ADP	IN	_	_	_	_	_
2	this	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
3	study	study	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
4	,	,	PUNCT	,	_	_	_	_	_
5	we	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
6	investigated	investigate	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
7	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
8	effects	effect	NOUN	NNS	Number=Plur	_	_	_	_
9	of	of	ADP	IN	_	_	_	_	_
10	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
11	commonly	commonly	ADV	RB	_	_	_	_	_
12	prescribed	prescri	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
13	anti-inflammatory	anti-inflammatory	ADJ	JJ	Degree=Pos	_	_	_	_
14	drug	drug	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
15	,	,	PUNCT	,	_	_	_	_	_
16	acetyl	acetyl	ADJ	JJ	Degree=Pos	_	_	_	_
17	salicylic	salicylic	ADJ	JJ	Degree=Pos	_	_	_	_
18	acid	acid	NOUN	NN	Number=Sing	_	_	_	_
19	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
20	ASA	ASA	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
21	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
22	,	,	PUNCT	,	_	_	_	_	_
23	on	on	ADP	IN	_	_	_	_	_
24	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
25	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
26	12	12	NUM	CD	NumType=Card	_	_	_	_
27	production	production	NOUN	NN	Number=Sing	_	_	_	_
28	and	and	CCONJ	CC	_	_	_	_	_
29	Th1	th1	NUM	CD	NumType=Card	_	_	_	_
30	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
31	development	development	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
32	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 7
# text = ASA was found to inhibit secretion of the IL-12 heterodimer as well as p40 monomer by human monocytic cells.
1	ASA	ASa	PROPN	NNP	Number=Sing	_	_	_	_
2	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
3	found	find	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
4	to	to	PART	TO	_	_	_	_	_
5	inhibit	inhibit	VERB	VB	VerbForm=Inf	_	_	_	_
6	secretion	secretion	NOUN	NN	Number=Sing	_	_	_	_
7	of	of	ADP	IN	_	_	_	_	_
8	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
9	IL	Il	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
10	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
11	12	12	NUM	CD	NumType=Card	_	_	_	_
12	heterodimer	heterodimer	NOUN	NN	Number=Sing	_	_	_	_
13	as	as	ADV	RB	_	_	_	_	_
14	well	well	ADV	RB	Degree=Pos	_	_	_	_
15	as	as	ADP	IN	_	_	_	_	_
16	p40	p40	NUM	CD	NumType=Card	_	_	_	_
17	monomer	monomer	NOUN	NN	Number=Sing	_	_	_	_
18	by	by	ADP	IN	_	_	_	_	_
19	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
20	monocytic	monocytic	ADJ	JJ	Degree=Pos	_	_	_	_
21	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
22	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 8
# text = This was associated with the down-regulation of IL-12p40 mRNA expression.
1	This	this	PRON	DT	Number=Sing|PronType=Dem	_	_	_	_
2	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
3	associated	associate	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
4	with	with	ADP	IN	_	_	_	_	_
5	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
6	down	down	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
7	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
8	regulation	regulation	NOUN	NN	Number=Sing	_	_	_	_
9	of	of	ADP	IN	_	_	_	_	_
10	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
11	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
12	12p40	12p40	NUM	CD	NumType=Card	_	_	_	_
13	mRNA	mRNa	NOUN	NN	Number=Sing	_	_	_	_
14	expression	expression	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
15	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 9
# text = Analysis of the regulation of the p40 gene promoter revealed that ASA inhibited NF-kappaB activation and binding to the p40-kappaB site in the p40 promoter, leading to transcriptional repression of the p40 gene.
1	Analysis	analysis	NOUN	NN	Number=Sing	_	_	_	_
2	of	of	ADP	IN	_	_	_	_	_
3	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
4	regulation	regulation	NOUN	NN	Number=Sing	_	_	_	_
5	of	of	ADP	IN	_	_	_	_	_
6	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
7	p40	p40	NUM	CD	NumType=Card	_	_	_	_
8	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
9	promoter	promoter	NOUN	NN	Number=Sing	_	_	_	_
10	revealed	reveal	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
11	that	that	SCONJ	IN	_	_	_	_	_
12	ASA	ASA	PROPN	NNP	Number=Sing	_	_	_	_
13	inhibited	inhibit	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
14	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
15	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
16	kappaB	kappaB	PROPN	NNP	Number=Sing	_	_	_	_
17	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
18	and	and	CCONJ	CC	_	_	_	_	_
19	binding	bind	VERB	VBG	VerbForm=Ger	_	_	_	_
20	to	to	ADP	IN	_	_	_	_	_
21	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
22	p40	p40	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
23	-kappaB	-kappab	NOUN	NN	Number=Sing	_	_	_	_
24	site	site	NOUN	NN	Number=Sing	_	_	_	_
25	in	in	ADP	IN	_	_	_	_	_
26	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
27	p40	p40	NOUN	NN	Number=Sing	_	_	_	_
28	promoter	promoter	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
29	,	,	PUNCT	,	_	_	_	_	_
30	leading	lead	VERB	VBG	VerbForm=Ger	_	_	_	_
31	to	to	ADP	IN	_	_	_	_	_
32	transcriptional	transcriptional	ADJ	JJ	Degree=Pos	_	_	_	_
33	repression	repression	NOUN	NN	Number=Sing	_	_	_	_
34	of	of	ADP	IN	_	_	_	_	_
35	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
36	p40	p40	NOUN	NN	Number=Sing	_	_	_	_
37	gene	gene	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
38	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 10
# text = Addition of ASA to an in vitro T helper cell differentiation system, at concentrations compatible with plasma levels reached during anti-inflammatory therapy, resulted in reduced development of Th1 cells.
1	Addition	Addition	PROPN	NNP	Number=Sing	_	_	_	_
2	of	of	ADP	IN	_	_	_	_	_
3	ASA	ASA	PROPN	NNP	Number=Sing	_	_	_	_
4	to	to	ADP	IN	_	_	_	_	_
5	an	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
6	in	in	ADP	IN	_	_	_	_	_
7	vitro	vitro	ADJ	JJ	Degree=Pos	_	_	_	_
8	T	T	PROPN	NNP	Number=Sing	_	_	_	_
9	helper	helper	NOUN	NN	Number=Sing	_	_	_	_
10	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
11	differentiation	differentiation	NOUN	NN	Number=Sing	_	_	_	_
12	system	system	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
13	,	,	PUNCT	,	_	_	_	_	_
14	at	at	ADP	IN	_	_	_	_	_
15	concentrations	concentration	NOUN	NNS	Number=Plur	_	_	_	_
16	compatible	compatible	ADJ	JJ	Degree=Pos	_	_	_	_
17	with	with	ADP	IN	_	_	_	_	_
18	plasma	plasma	NOUN	NN	Number=Sing	_	_	_	_
19	levels	level	NOUN	NNS	Number=Plur	_	_	_	_
20	reached	reach	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
21	during	during	ADP	IN	_	_	_	_	_
22	anti-inflammatory	anti-inflammatory	ADJ	JJ	Degree=Pos	_	_	_	_
23	therapy	therapy	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
24	,	,	PUNCT	,	_	_	_	_	_
25	resulted	result	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
26	in	in	ADP	IN	_	_	_	_	_
27	reduced	reduce	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
28	development	development	NOUN	NN	Number=Sing	_	_	_	_
29	of	of	ADP	IN	_	_	_	_	_
30	Th1	Th1	NUM	CD	NumType=Card	_	_	_	_
31	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
32	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 11
# text = These results suggest that the inhibition of NF-kappaB activation by ASA leads to down-regulation of IL-12 production and inhibition of Th1 cell development.
1	These	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
2	results	result	NOUN	NNS	Number=Plur	_	_	_	_
3	suggest	suggest	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
4	that	that	SCONJ	IN	_	_	_	_	_
5	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
6	inhibition	inhibition	NOUN	NN	Number=Sing	_	_	_	_
7	of	of	ADP	IN	_	_	_	_	_
8	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
9	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
10	kappaB	kappaB	PROPN	NNP	Number=Sing	_	_	_	_
11	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
12	by	by	ADP	IN	_	_	_	_	_
13	ASA	ASa	PROPN	NNP	Number=Sing	_	_	_	_
14	leads	lead	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
15	to	to	ADP	IN	_	_	_	_	_
16	down	down	ADV	RB	_	_	_	_	SpaceAfter=No
17	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
18	regulation	regulation	NOUN	NN	Number=Sing	_	_	_	_
19	of	of	ADP	IN	_	_	_	_	_
20	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
21	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
22	12	12	NUM	CD	NumType=Card	_	_	_	_
23	production	production	NOUN	NN	Number=Sing	_	_	_	_
24	and	and	CCONJ	CC	_	_	_	_	_
25	inhibition	inhibition	NOUN	NN	Number=Sing	_	_	_	_
26	of	of	ADP	IN	_	_	_	_	_
27	Th1	Th1	NUM	CD	NumType=Card	_	_	_	_
28	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
29	development	development	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
30	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 12
# text = Document 0030020 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	0030020	0030020	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 13
# text = NF-kappa B controls expression of inhibitor
1	NF	Nf	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
2	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
3	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_
4	B	b	NOUN	NN	Number=Sing	_	_	_	_
5	controls	controls	NOUN	NN	Number=Sing	_	_	_	_
6	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
7	of	of	ADP	IN	_	_	_	_	_
8	inhibitor	inhibitor	NOUN	NN	Number=Sing	_	_	_	_

# sent_id = 14
# text = I kappa
1	I	I	PRON	PRP	Case=Nom|Number=Sing|Person=1|PronType=Prs	_	_	_	_
2	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_

# sent_id = 15
# text = B alpha:
1	B	b	NOUN	NN	Number=Sing	_	_	_	_
2	alpha	alpha	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
3	:	:	PUNCT	:	_	_	_	_	_

# sent_id = 16
# text = evidence for an inducible autoregulatory pathway.
1	evidence	evidence	NOUN	NN	Number=Sing	_	_	_	_
2	for	for	ADP	IN	_	_	_	_	_
3	an	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
4	inducible	inducible	ADJ	JJ	Degree=Pos	_	_	_	_
5	autoregulatory	autoregulatory	ADJ	JJ	Degree=Pos	_	_	_	_
6	pathway	pathway	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
7	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 17
# text = The eukaryotic transcription factor nuclear factor-kappa B (NF-kappa B) participates in many parts of the genetic program mediating T lymphocyte activation and growth.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	eukaryotic	eukaryotic	ADJ	JJ	Degree=Pos	_	_	_	_
3	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
4	factor	factor	NOUN	NN	Number=Sing	_	_	_	_
5	nuclear	nuclear	ADJ	JJ	Degree=Pos	_	_	_	_
6	factor	factor	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
7	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
8	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_
9	B	b	NOUN	NN	Number=Sing	_	_	_	_
10	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
11	NF	Nf	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
12	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
13	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_
14	B	b	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
15	)	)	PUNCT	-RRB-	_	_	_	_	_
16	participates	participate	NOUN	NNS	Number=Plur	_	_	_	_
17	in	in	ADP	IN	_	_	_	_	_
18	many	many	ADJ	JJ	Degree=Pos	_	_	_	_
19	parts	part	NOUN	NNS	Number=Plur	_	_	_	_
20	of	of	ADP	IN	_	_	_	_	_
21	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
22	genetic	genetic	ADJ	JJ	Degree=Pos	_	_	_	_
23	program	program	NOUN	NN	Number=Sing	_	_	_	_
24	mediating	mediat	VERB	VBG	VerbForm=Ger	_	_	_	_
25	T	t	PROPN	NNP	Number=Sing	_	_	_	_
26	lymphocyte	lymphocyte	NOUN	NN	Number=Sing	_	_	_	_
27	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
28	and	and	CCONJ	CC	_	_	_	_	_
29	growth	growth	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
30	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 18
# text = Nuclear expression of NF-kappa B occurs after its induced dissociation from its cytoplasmic inhibitor
1	Nuclear	nuclear	ADJ	JJ	Degree=Pos	_	_	_	_
2	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
3	of	of	ADP	IN	_	_	_	_	_
4	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
5	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
6	kappa	kappa	PROPN	NNP	Number=Sing	_	_	_	_
7	B	b	PROPN	NNP	Number=Sing	_	_	_	_
8	occurs	occur	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
9	after	after	ADP	IN	_	_	_	_	_
10	its	its	PRON	PRP$	Gender=Neut|Number=Sing|Person=3|Poss=Yes|PronType=Prs	_	_	_	_
11	induced	induce	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
12	dissociation	dissociation	NOUN	NN	Number=Sing	_	_	_	_
13	from	from	ADP	IN	_	_	_	_	_
14	its	its	PRON	PRP$	Gender=Neut|Number=Sing|Person=3|Poss=Yes|PronType=Prs	_	_	_	_
15	cytoplasmic	cytoplasmic	ADJ	JJ	Degree=Pos	_	_	_	_
16	inhibitor	inhibitor	NOUN	NN	Number=Sing	_	_	_	_

# sent_id = 19
# text = I kappa B alpha.
1	I	I	PRON	PRP	Case=Nom|Number=Sing|Person=1|PronType=Prs	_	_	_	_
2	kappa	kappa	X	FW	Foreign=Yes	_	_	_	_
3	B	b	ADJ	JJ	Degree=Pos	_	_	_	_
4	alpha	alpha	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
5	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 20
# text = Phorbol ester and tumor necrosis factor-alpha induction of nuclear NF-kappa B is associated with both the degradation of performed I kappa B alpha and the activation of I kappa B alpha gene expression.
1	Phorbol	Phorbol	NOUN	NN	Number=Sing	_	_	_	_
2	ester	ester	NOUN	NN	Number=Sing	_	_	_	_
3	and	and	CCONJ	CC	_	_	_	_	_
4	tumor	tumor	NOUN	NN	Number=Sing	_	_	_	_
5	necrosis	necrosis	NOUN	NN	Number=Sing	_	_	_	_
6	factor	factor	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
7	-alpha	-alpha	NOUN	NN	Number=Sing	_	_	_	_
8	induction	induction	NOUN	NN	Number=Sing	_	_	_	_
9	of	of	ADP	IN	_	_	_	_	_
10	nuclear	nuclear	ADJ	JJ	Degree=Pos	_	_	_	_
11	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
12	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
13	kappa	kappa	PROPN	NNP	Number=Sing	_	_	_	_
14	B	b	PROPN	NNP	Number=Sing	_	_	_	_
15	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
16	associated	associate	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
17	with	with	ADP	IN	_	_	_	_	_
18	both	both	CCONJ	CC	_	_	_	_	_
19	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
20	degradation	degradation	NOUN	NN	Number=Sing	_	_	_	_
21	of	of	ADP	IN	_	_	_	_	_
22	performed	perform	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
23	I	I	PRON	PRP	Case=Nom|Number=Sing|Person=1|PronType=Prs	_	_	_	_
24	kappa	kappa	PROPN	NNP	Number=Sing	_	_	_	_
25	B	b	PROPN	NNP	Number=Sing	_	_	_	_
26	alpha	alpha	PROPN	NNP	Number=Sing	_	_	_	_
27	and	and	CCONJ	CC	_	_	_	_	_
28	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
29	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
30	of	of	ADP	IN	_	_	_	_	_
31	I	I	PRON	PRP	Case=Nom|Number=Sing|Person=1|PronType=Prs	_	_	_	_
32	kappa	kappa	PROPN	NNP	Number=Sing	_	_	_	_
33	B	B	PROPN	NNP	Number=Sing	_	_	_	_
34	alpha	alpha	ADV	RB	_	_	_	_	_
35	gene	gene	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
36	expression	expression	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
37	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 21
# text = Transfection studies indicate that the I kappa B alpha gene is specifically induced by the 65-kilodalton transactivating subunit of NF-kappa B.
1	Transfection	Transfection	NOUN	NN	Number=Sing	_	_	_	_
2	studies	study	NOUN	NNS	Number=Plur	_	_	_	_
3	indicate	indicate	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
4	that	that	SCONJ	IN	_	_	_	_	_
5	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
6	I	I	PRON	PRP	Case=Nom|Number=Sing|Person=1|PronType=Prs	_	_	_	_
7	kappa	kappa	X	GW	_	_	_	_	_
8	B	b	X	GW	_	_	_	_	_
9	alpha	alpha	X	GW	_	_	_	_	_
10	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
11	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
12	specifically	specifically	ADV	RB	_	_	_	_	_
13	induced	induce	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
14	by	by	ADP	IN	_	_	_	_	_
15	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
16	65	65	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
17	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
18	kilodalton	kilodalton	NOUN	NN	Number=Sing	_	_	_	_
19	transactivating	transactivat	VERB	VBG	VerbForm=Ger	_	_	_	_
20	subunit	subunit	NOUN	NN	Number=Sing	_	_	_	_
21	of	of	ADP	IN	_	_	_	_	_
22	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
23	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
24	kappa	kappa	PROPN	NNP	Number=Sing	_	_	_	_
25	B.	B.	PROPN	NNP	Number=Sing	_	_	_	_

# sent_id = 22
# text = Association of the newly synthesized I kappa B alpha with p65 restores intracellular inhibition of NF-kappa B DNA binding activity and prolongs the survival of this labile inhibitor.
1	Association	Association	NOUN	NN	Number=Sing	_	_	_	_
2	of	of	ADP	IN	_	_	_	_	_
3	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
4	newly	newly	ADV	RB	_	_	_	_	_
5	synthesized	synthesize	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
6	I	I	PRON	PRP	Case=Nom|Number=Sing|Person=1|PronType=Prs	_	_	_	_
7	kappa	kappa	X	FW	Foreign=Yes	_	_	_	_
8	B	b	ADJ	JJ	Degree=Pos	_	_	_	_
9	alpha	alpha	NOUN	NN	Number=Sing	_	_	_	_
10	with	with	ADP	IN	_	_	_	_	_
11	p65	p65	NUM	CD	NumType=Card	_	_	_	_
12	restores	restore	NOUN	NNS	Number=Plur	_	_	_	_
13	intracellular	intracellular	ADJ	JJ	Degree=Pos	_	_	_	_
14	inhibition	inhibition	NOUN	NN	Number=Sing	_	_	_	_
15	of	of	ADP	IN	_	_	_	_	_
16	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
17	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
18	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_
19	B	b	NOUN	NN	Number=Sing	_	_	_	_
20	DNA	dna	NOUN	NN	Number=Sing	_	_	_	_
21	binding	binde	VERB	VBG	VerbForm=Ger	_	_	_	_
22	activity	activity	NOUN	NN	Number=Sing	_	_	_	_
23	and	and	CCONJ	CC	_	_	_	_	_
24	prolongs	prolong	VERB	VB	VerbForm=Inf	_	_	_	_
25	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
26	survival	survival	NOUN	NN	Number=Sing	_	_	_	_
27	of	of	ADP	IN	_	_	_	_	_
28	this	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
29	labile	labile	NOUN	NN	Number=Sing	_	_	_	_
30	inhibitor	inhibitor	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
31	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 23
# text = Together, these results show that NF-kappa B controls the expression of I kappa B alpha by means of an inducible autoregulatory pathway.
1	Together	together	ADV	RB	_	_	_	_	SpaceAfter=No
2	,	,	PUNCT	,	_	_	_	_	_
3	these	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
4	results	result	NOUN	NNS	Number=Plur	_	_	_	_
5	show	show	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
6	that	that	SCONJ	IN	_	_	_	_	_
7	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
8	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
9	kappa	kappa	PROPN	NNP	Number=Sing	_	_	_	_
10	B	b	PROPN	NNP	Number=Sing	_	_	_	_
11	controls	control	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
12	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
13	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
14	of	of	ADP	IN	_	_	_	_	_
15	I	I	PRON	PRP	Case=Nom|Number=Sing|Person=1|PronType=Prs	_	_	_	_
16	kappa	kappa	PROPN	NNP	Number=Sing	_	_	_	_
17	B	b	PROPN	NNP	Number=Sing	_	_	_	_
18	alpha	alpha	ADV	RB	_	_	_	_	_
19	by	by	ADP	IN	_	_	_	_	_
20	means	means	NOUN	NNS	Number=Plur	_	_	_	_
21	of	of	ADP	IN	_	_	_	_	_
22	an	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
23	inducible	inducible	ADJ	JJ	Degree=Pos	_	_	_	_
24	autoregulatory	autoregulatory	ADJ	JJ	Degree=Pos	_	_	_	_
25	pathway	pathway	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
26	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 24
# text = Document 00300212 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	00300212	00300212	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 25
# text = Activation of the NF-kappaB transcription factor in a T-lymphocytic cell line by hypochlorous acid.
1	Activation	Activation	NOUN	NN	Number=Sing	_	_	_	_
2	of	of	ADP	IN	_	_	_	_	_
3	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
4	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
5	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
6	kappaB	kappaB	PROPN	NNP	Number=Sing	_	_	_	_
7	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
8	factor	factor	NOUN	NN	Number=Sing	_	_	_	_
9	in	in	ADP	IN	_	_	_	_	_
10	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
11	T-	T-	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
12	lymphocytic	lymphocytic	ADJ	JJ	Degree=Pos	_	_	_	_
13	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
14	line	line	NOUN	NN	Number=Sing	_	_	_	_
15	by	by	ADP	IN	_	_	_	_	_
16	hypochlorous	hypochlorous	ADJ	JJ	Degree=Pos	_	_	_	_
17	acid	acid	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
18	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 26
# text = Reactive oxygen species (ROS) such as hydrogen peroxide serve as second messengers in the induction of the transcription factor NF-kappaB, and hence in the activation and replication of human immunodeficiency virus type 1 (HIV-1) in human cells.
1	Reactive	Reactive	ADJ	JJ	Degree=Pos	_	_	_	_
2	oxygen	oxygen	NOUN	NN	Number=Sing	_	_	_	_
3	species	species	NOUN	NNS	Number=Plur	_	_	_	_
4	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
5	ROS	Ro	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
6	)	)	PUNCT	-RRB-	_	_	_	_	_
7	such	such	ADJ	JJ	Degree=Pos	_	_	_	_
8	as	as	ADP	IN	_	_	_	_	_
9	hydrogen	hydrogen	NUM	CD	NumType=Card	_	_	_	_
10	peroxide	peroxide	NOUN	NN	Number=Sing	_	_	_	_
11	serve	serve	VERB	VB	VerbForm=Inf	_	_	_	_
12	as	as	ADP	IN	_	_	_	_	_
13	second	second	ADJ	JJ	Degree=Pos|NumType=Ord	_	_	_	_
14	messengers	messenger	NOUN	NNS	Number=Plur	_	_	_	_
15	in	in	ADP	IN	_	_	_	_	_
16	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
17	induction	induction	NOUN	NN	Number=Sing	_	_	_	_
18	of	of	ADP	IN	_	_	_	_	_
19	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
20	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
21	factor	factor	NOUN	NN	Number=Sing	_	_	_	_
22	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
23	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
24	kappaB	kappaB	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
25	,	,	PUNCT	,	_	_	_	_	_
26	and	and	CCONJ	CC	_	_	_	_	_
27	hence	hence	ADV	RB	_	_	_	_	_
28	in	in	ADP	IN	_	_	_	_	_
29	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
30	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
31	and	and	CCONJ	CC	_	_	_	_	_
32	replication	replication	NOUN	NN	Number=Sing	_	_	_	_
33	of	of	ADP	IN	_	_	_	_	_
34	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
35	immunodeficiency	immunodeficiency	NOUN	NN	Number=Sing	_	_	_	_
36	virus	virus	NOUN	NN	Number=Sing	_	_	_	_
37	type	type	NOUN	NN	Number=Sing	_	_	_	_
38	1	1	NUM	CD	NumType=Card	_	_	_	_
39	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
40	HIV	Hiv	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
41	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
42	1	1	X	LS	_	_	_	_	SpaceAfter=No
43	)	)	PUNCT	-RRB-	_	_	_	_	_
44	in	in	ADP	IN	_	_	_	_	_
45	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
46	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
47	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 27
# text = During inflammatory reactions, many oxidative species are produced, one of which is hypochlorous acid (HOCl), which is responsible for the microbicidal effects of activated human polymorphonuclear leukocytes.
1	During	during	ADP	IN	_	_	_	_	_
2	inflammatory	inflammatory	ADJ	JJ	Degree=Pos	_	_	_	_
3	reactions	reaction	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	,	,	PUNCT	,	_	_	_	_	_
5	many	many	ADJ	JJ	Degree=Pos	_	_	_	_
6	oxidative	oxidative	ADJ	JJ	Degree=Pos	_	_	_	_
7	species	species	NOUN	NNS	Number=Plur	_	_	_	_
8	are	be	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
9	produced	produce	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	SpaceAfter=No
10	,	,	PUNCT	,	_	_	_	_	_
11	one	one	NUM	CD	NumType=Card	_	_	_	_
12	of	of	ADP	IN	_	_	_	_	_
13	which	which	PRON	WDT	PronType=Int	_	_	_	_
14	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
15	hypochlorous	hypochlorous	ADV	RB	_	_	_	_	_
16	acid	acid	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
17	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
18	HOCl	HOCl	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
19	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
20	,	,	PUNCT	,	_	_	_	_	_
21	which	which	PRON	WDT	PronType=Rel	_	_	_	_
22	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
23	responsible	responsible	ADJ	JJ	Degree=Pos	_	_	_	_
24	for	for	ADP	IN	_	_	_	_	_
25	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
26	microbicidal	microbicidal	ADJ	JJ	Degree=Pos	_	_	_	_
27	effects	effect	NOUN	NNS	Number=Plur	_	_	_	_
28	of	of	ADP	IN	_	_	_	_	_
29	activated	activate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
30	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
31	polymorphonuclear	polymorphonuclear	NOUN	NN	Number=Sing	_	_	_	_
32	leukocytes	leukocyte	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
33	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 28
# text = Treatment of a T-lymphocytic cell line with micromolar concentrations of
1	Treatment	treatment	NOUN	NN	Number=Sing	_	_	_	_
2	of	of	ADP	IN	_	_	_	_	_
3	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
4	T-	T-	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
5	lymphocytic	lymphocytic	ADJ	JJ	Degree=Pos	_	_	_	_
6	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
7	line	line	NOUN	NN	Number=Sing	_	_	_	_
8	with	with	ADP	IN	_	_	_	_	_
9	micromolar	micromolar	ADJ	JJ	Degree=Pos	_	_	_	_
10	concentrations	concentration	NOUN	NNS	Number=Plur	_	_	_	_
11	of	of	ADP	IN	_	_	_	_	_

# sent_id = 29
# text = HOCl promoted the appearance of transcription factor NF-kappaB (the heterodimer p50/p65) in the nucleus of the cells, even in the absence of de novo protein synthesis.
1	HOCl	HOCl	PROPN	NNP	Number=Sing	_	_	_	_
2	promoted	promote	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
3	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
4	appearance	appearance	NOUN	NN	Number=Sing	_	_	_	_
5	of	of	ADP	IN	_	_	_	_	_
6	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
7	factor	factor	NOUN	NN	Number=Sing	_	_	_	_
8	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
9	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
10	kappaB	kappaB	PROPN	NNP	Number=Sing	_	_	_	_
11	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
12	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
13	heterodimer	heterodimer	NOUN	NN	Number=Sing	_	_	_	_
14	p50	p50	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
15	/	/	PUNCT	,	_	_	_	_	SpaceAfter=No
16	p65	p65	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
17	)	)	PUNCT	-RRB-	_	_	_	_	_
18	in	in	ADP	IN	_	_	_	_	_
19	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
20	nucleus	nucleus	NOUN	NN	Number=Sing	_	_	_	_
21	of	of	ADP	IN	_	_	_	_	_
22	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
23	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
24	,	,	PUNCT	,	_	_	_	_	_
25	even	even	ADV	RB	_	_	_	_	_
26	in	in	ADP	IN	_	_	_	_	_
27	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
28	absence	absence	NOUN	NN	Number=Sing	_	_	_	_
29	of	of	ADP	IN	_	_	_	_	_
30	de	de	NOUN	NN	Number=Sing	_	_	_	_
31	novo	novo	NOUN	NN	Number=Sing	_	_	_	_
32	protein	protein	NOUN	NN	Number=Sing	_	_	_	_
33	synthesis	synthesis	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
34	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 30
# text = Western blot analysis of the NF-kappaB inhibitory subunits (IkappaB) demonstrated that both IkappaB-alpha proteolysis and p105 processing were induced by the treatment.
1	Western	western	ADJ	JJ	Degree=Pos	_	_	_	_
2	blot	blot	NOUN	NN	Number=Sing	_	_	_	_
3	analysis	analysis	NOUN	NN	Number=Sing	_	_	_	_
4	of	of	ADP	IN	_	_	_	_	_
5	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
6	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
7	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
8	kappaB	kappaB	PROPN	NNP	Number=Sing	_	_	_	_
9	inhibitory	inhibitory	NOUN	NN	Number=Sing	_	_	_	_
10	subunits	subunit	NOUN	NNS	Number=Plur	_	_	_	_
11	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
12	IkappaB	IkappaB	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
13	)	)	PUNCT	-RRB-	_	_	_	_	_
14	demonstrated	demonstrate	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
15	that	that	SCONJ	IN	_	_	_	_	_
16	both	both	DET	DT	_	_	_	_	_
17	IkappaB	Ikappab	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
18	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
19	alpha	alpha	NOUN	NN	Number=Sing	_	_	_	_
20	proteolysis	proteolysis	NOUN	NN	Number=Sing	_	_	_	_
21	and	and	CCONJ	CC	_	_	_	_	_
22	p105	p105	NUM	CD	NumType=Card	_	_	_	_
23	processing	processing	NOUN	NN	Number=Sing	_	_	_	_
24	were	be	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
25	induced	induce	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
26	by	by	ADP	IN	_	_	_	_	_
27	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
28	treatment	treatment	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
29	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 31
# text = NF-kappaB activation was very effective when cells were subjected to hyperthermia before being treated with HOCl.
1	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
2	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
3	kappaB	kappaB	PROPN	NNP	Number=Sing	_	_	_	_
4	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
5	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
6	very	very	ADV	RB	_	_	_	_	_
7	effective	effective	ADJ	JJ	Degree=Pos	_	_	_	_
8	when	when	ADV	WRB	PronType=Int	_	_	_	_
9	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
10	were	be	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
11	subjected	subject	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
12	to	to	ADP	IN	_	_	_	_	_
13	hyperthermia	hyperthermia	NOUN	NN	Number=Sing	_	_	_	_
14	before	before	SCONJ	IN	_	_	_	_	_
15	being	be	AUX	VBG	VerbForm=Ger	_	_	_	_
16	treated	treat	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
17	with	with	ADP	IN	_	_	_	_	_
18	HOCl	HOCl	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
19	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 32
# text = Various antioxidants, such as pyrrolidine dithiocarbamate, p-bromophenacyl-bromide and nordihydroguaiaretic acid could strongly reduce NF-kappaB translocation, demonstrating the importance of oxidative species in the transduction mechanism.
1	Various	various	ADJ	JJ	Degree=Pos	_	_	_	_
2	antioxidants	antioxidant	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
3	,	,	PUNCT	,	_	_	_	_	_
4	such	such	ADJ	JJ	Degree=Pos	_	_	_	_
5	as	as	ADP	IN	_	_	_	_	_
6	pyrrolidine	pyrrolidine	ADJ	JJ	Degree=Pos	_	_	_	_
7	dithiocarbamate	dithiocarbamate	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
8	,	,	PUNCT	,	_	_	_	_	_
9	p-bromophenacyl-bromide	p-bromophenacyl-bromide	ADJ	JJ	Degree=Pos	_	_	_	_
10	and	and	CCONJ	CC	_	_	_	_	_
11	nordihydroguaiaretic	nordihydroguaiaretic	ADJ	JJ	Degree=Pos	_	_	_	_
12	acid	acid	NOUN	NN	Number=Sing	_	_	_	_
13	could	could	AUX	MD	VerbForm=Fin	_	_	_	_
14	strongly	strongly	ADV	RB	_	_	_	_	_
15	reduce	reduce	VERB	VB	VerbForm=Inf	_	_	_	_
16	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
17	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
18	kappaB	kappaB	PROPN	NNP	Number=Sing	_	_	_	_
19	translocation	translocation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
20	,	,	PUNCT	,	_	_	_	_	_
21	demonstrating	demonstrat	VERB	VBG	VerbForm=Ger	_	_	_	_
22	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
23	importance	importance	NOUN	NN	Number=Sing	_	_	_	_
24	of	of	ADP	IN	_	_	_	_	_
25	oxidative	oxidative	ADJ	JJ	Degree=Pos	_	_	_	_
26	species	species	NOUN	NNS	Number=Plur	_	_	_	_
27	in	in	ADP	IN	_	_	_	_	_
28	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
29	transduction	transduction	NOUN	NN	Number=Sing	_	_	_	_
30	mechanism	mechanism	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
31	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 33
# text = Moreover, ACH-2 cells treated with HOCl or H2O2 released tumour necrosis factor-alpha (TNF-alpha) in the supernatants.
1	Moreover	moreover	ADV	RB	_	_	_	_	SpaceAfter=No
2	,	,	PUNCT	,	_	_	_	_	_
3	ACH	ACH	DET	DT	_	_	_	_	SpaceAfter=No
4	-	-	SYM	SYM	_	_	_	_	SpaceAfter=No
5	2	2	NUM	CD	NumType=Card	_	_	_	_
6	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
7	treated	treat	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
8	with	with	ADP	IN	_	_	_	_	_
9	HOCl	HOCl	PROPN	NNP	Number=Sing	_	_	_	_
10	or	or	CCONJ	CC	_	_	_	_	_
11	H2O2	H2O2	PART	TO	Abbr=Yes	_	_	_	_
12	released	release	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
13	tumour	tumour	NOUN	NN	Number=Sing	_	_	_	_
14	necrosis	necrosis	NOUN	NN	Number=Sing	_	_	_	_
15	factor	factor	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
16	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
17	alpha	alpha	NOUN	NN	Number=Sing	_	_	_	_
18	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
19	TNF	Tnf	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
20	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
21	alpha	alpha	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
22	)	)	PUNCT	-RRB-	_	_	_	_	_
23	in	in	ADP	IN	_	_	_	_	_
24	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
25	supernatants	supernatant	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
26	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 34
# text = The importance of TNF-alpha release in NF-kappaB induction by HOCl or H2O2 was demonstrated by the fact that: (1) the nuclear appearance of NF-kappaB was promoted in untreated cells; and (2) synergism between TNF-alpha and HOCl was detected.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	importance	importance	NOUN	NN	Number=Sing	_	_	_	_
3	of	of	ADP	IN	_	_	_	_	_
4	TNF	TNF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
5	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
6	alpha	alpha	NOUN	NN	Number=Sing	_	_	_	_
7	release	release	NOUN	NN	Number=Sing	_	_	_	_
8	in	in	ADP	IN	_	_	_	_	_
9	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
10	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
11	kappaB	kappaB	PROPN	NNP	Number=Sing	_	_	_	_
12	induction	induction	NOUN	NN	Number=Sing	_	_	_	_
13	by	by	ADP	IN	_	_	_	_	_
14	HOCl	HOCl	PROPN	NNP	Number=Sing	_	_	_	_
15	or	or	CCONJ	CC	_	_	_	_	_
16	H2O2	H2O2	NOUN	NN	Number=Sing	_	_	_	_
17	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
18	demonstrated	demonstrate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
19	by	by	ADP	IN	_	_	_	_	_
20	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
21	fact	fact	NOUN	NN	Number=Sing	_	_	_	_
22	that	that	SCONJ	IN	_	_	_	_	SpaceAfter=No
23	:	:	PUNCT	:	_	_	_	_	_
24	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
25	1	1	X	LS	_	_	_	_	SpaceAfter=No
26	)	)	PUNCT	-RRB-	_	_	_	_	_
27	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
28	nuclear	nuclear	ADJ	JJ	Degree=Pos	_	_	_	_
29	appearance	appearance	NOUN	NN	Number=Sing	_	_	_	_
30	of	of	ADP	IN	_	_	_	_	_
31	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
32	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
33	kappaB	kappaB	PROPN	NNP	Number=Sing	_	_	_	_
34	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
35	promoted	promote	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
36	in	in	ADP	IN	_	_	_	_	_
37	untreated	untreated	ADJ	JJ	Degree=Pos	_	_	_	_
38	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
39	;	;	PUNCT	,	_	_	_	_	_
40	and	and	CCONJ	CC	_	_	_	_	_
41	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
42	2	2	X	LS	_	_	_	_	SpaceAfter=No
43	)	)	PUNCT	-RRB-	_	_	_	_	_
44	synergism	synergism	NOUN	NN	Number=Sing	_	_	_	_
45	between	between	ADP	IN	_	_	_	_	_
46	TNF	TNF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
47	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
48	alpha	alpha	PROPN	NNP	Number=Sing	_	_	_	_
49	and	and	CCONJ	CC	_	_	_	_	_
50	HOCl	HOCl	PROPN	NNP	Number=Sing	_	_	_	_
51	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
52	detected	detect	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	SpaceAfter=No
53	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 35
# text = Collectively, these results suggest that HOCl should be considered as an oxidative species capable of inducing NF-kappaB in a T-lymphocytic cell line through a transduction mechanism involving ROS, and having a long-distance effect through subsequent TNF-alpha release.
1	Collectively	collectively	ADV	RB	_	_	_	_	SpaceAfter=No
2	,	,	PUNCT	,	_	_	_	_	_
3	these	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
4	results	result	NOUN	NNS	Number=Plur	_	_	_	_
5	suggest	suggest	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
6	that	that	SCONJ	IN	_	_	_	_	_
7	HOCl	HOCl	PROPN	NNP	Number=Sing	_	_	_	_
8	should	should	AUX	MD	VerbForm=Fin	_	_	_	_
9	be	be	AUX	VB	VerbForm=Inf	_	_	_	_
10	considered	consider	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
11	as	as	ADP	IN	_	_	_	_	_
12	an	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
13	oxidative	oxidative	ADJ	JJ	Degree=Pos	_	_	_	_
14	species	species	NOUN	NNS	Number=Plur	_	_	_	_
15	capable	capable	ADJ	JJ	Degree=Pos	_	_	_	_
16	of	of	SCONJ	IN	_	_	_	_	_
17	inducing	induce	VERB	VBG	VerbForm=Ger	_	_	_	_
18	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
19	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
20	kappaB	kappaB	PROPN	NNP	Number=Sing	_	_	_	_
21	in	in	ADP	IN	_	_	_	_	_
22	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
23	T-	t-	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
24	lymphocytic	lymphocytic	ADJ	JJ	Degree=Pos	_	_	_	_
25	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
26	line	line	NOUN	NN	Number=Sing	_	_	_	_
27	through	through	ADP	IN	_	_	_	_	_
28	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
29	transduction	transduction	NOUN	NN	Number=Sing	_	_	_	_
30	mechanism	mechanism	NOUN	NN	Number=Sing	_	_	_	_
31	involving	involve	VERB	VBG	VerbForm=Ger	_	_	_	_
32	ROS	Ro	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
33	,	,	PUNCT	,	_	_	_	_	_
34	and	and	CCONJ	CC	_	_	_	_	_
35	having	have	VERB	VBG	VerbForm=Ger	_	_	_	_
36	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
37	long	long	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
38	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
39	distance	distance	NOUN	NN	Number=Sing	_	_	_	_
40	effect	effect	NOUN	NN	Number=Sing	_	_	_	_
41	through	through	ADP	IN	_	_	_	_	_
42	subsequent	subsequent	ADJ	JJ	Degree=Pos	_	_	_	_
43	TNF	Tnf	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
44	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
45	alpha	alpha	NOUN	NN	Number=Sing	_	_	_	_
46	release	release	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
47	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 36
# text = Document 00300215 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	00300215	00300215	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 37
# text = Human interferon regulatory factor 2 gene.
1	Human	human	ADJ	JJ	Degree=Pos	_	_	_	_
2	interferon	interferon	ADP	IN	_	_	_	_	_
3	regulatory	regulatory	ADJ	JJ	Degree=Pos	_	_	_	_
4	factor	factor	NOUN	NN	Number=Sing	_	_	_	_
5	2	2	NUM	CD	NumType=Card	_	_	_	_
6	gene	gene	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
7	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 38
# text = Intron-exon organization and functional analysis of 5'-flanking region.
1	Intron-exon	Intron-exon	ADP	IN	_	_	_	_	_
2	organization	organization	NOUN	NN	Number=Sing	_	_	_	_
3	and	and	CCONJ	CC	_	_	_	_	_
4	functional	functional	ADJ	JJ	Degree=Pos	_	_	_	_
5	analysis	analysis	NOUN	NN	Number=Sing	_	_	_	_
6	of	of	ADP	IN	_	_	_	_	_
7	5	5	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
8	'	'	PUNCT	''	_	_	_	_	SpaceAfter=No
9	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
10	flanking	flanking	VERB	VBG	VerbForm=Ger	_	_	_	_
11	region	region	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
12	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 39
# text = Interferon regulatory factor 2 (IRF-2) is a transcriptional regulatory protein that terminates interferon beta expression initiated by interferon regulatory factor
1	Interferon	Interferon	PROPN	NNP	Number=Sing	_	_	_	_
2	regulatory	regulatory	ADJ	JJ	Degree=Pos	_	_	_	_
3	factor	factor	NOUN	NN	Number=Sing	_	_	_	_
4	2	2	NUM	CD	NumType=Card	_	_	_	_
5	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
6	IRF	Irf	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
7	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
8	2	2	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
9	)	)	PUNCT	-RRB-	_	_	_	_	_
10	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
11	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
12	transcriptional	transcriptional	ADJ	JJ	Degree=Pos	_	_	_	_
13	regulatory	regulatory	ADJ	JJ	Degree=Pos	_	_	_	_
14	protein	protein	NOUN	NN	Number=Sing	_	_	_	_
15	that	that	PRON	WDT	PronType=Rel	_	_	_	_
16	terminates	terminate	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
17	interferon	interferon	ADP	IN	_	_	_	_	_
18	beta	beta	NOUN	NN	Number=Sing	_	_	_	_
19	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
20	initiated	initiate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
21	by	by	ADP	IN	_	_	_	_	_
22	interferon	interferon	ADJ	JJ	Degree=Pos	_	_	_	_
23	regulatory	regulatory	ADJ	JJ	Degree=Pos	_	_	_	_
24	factor	factor	NOUN	NN	Number=Sing	_	_	_	_

# sent_id = 40
# text = 1.
1	1	1	X	LS	_	_	_	_	SpaceAfter=No
2	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 41
# text = In this study, we isolated the genomic DNA for human IRF-2 gene, determined the intron-exon structure of the human IRF-2 gene, mapped the major transcription initiation site, identified a number of potential regulatory elements in the 5'-flanking region, and localized the IRF-2 gene on human chromosome 4.
1	In	in	ADP	IN	_	_	_	_	_
2	this	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
3	study	study	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
4	,	,	PUNCT	,	_	_	_	_	_
5	we	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
6	isolated	isolate	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
7	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
8	genomic	genomic	ADJ	JJ	Degree=Pos	_	_	_	_
9	DNA	dna	NOUN	NN	Number=Sing	_	_	_	_
10	for	for	ADP	IN	_	_	_	_	_
11	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
12	IRF	IRF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
13	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
14	2	2	NUM	CD	NumType=Card	_	_	_	_
15	gene	gene	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
16	,	,	PUNCT	,	_	_	_	_	_
17	determined	determine	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
18	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
19	intron	intron	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
20	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
21	exon	exon	NOUN	NN	Number=Sing	_	_	_	_
22	structure	structure	NOUN	NN	Number=Sing	_	_	_	_
23	of	of	ADP	IN	_	_	_	_	_
24	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
25	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
26	IRF	Irf	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
27	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
28	2	2	NUM	CD	NumType=Card	_	_	_	_
29	gene	gene	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
30	,	,	PUNCT	,	_	_	_	_	_
31	mapped	map	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
32	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
33	major	major	ADJ	JJ	Degree=Pos	_	_	_	_
34	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
35	initiation	initiation	NOUN	NN	Number=Sing	_	_	_	_
36	site	site	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
37	,	,	PUNCT	,	_	_	_	_	_
38	identified	identify	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
39	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
40	number	number	NOUN	NN	Number=Sing	_	_	_	_
41	of	of	ADP	IN	_	_	_	_	_
42	potential	potential	ADJ	JJ	Degree=Pos	_	_	_	_
43	regulatory	regulatory	ADJ	JJ	Degree=Pos	_	_	_	_
44	elements	element	NOUN	NNS	Number=Plur	_	_	_	_
45	in	in	ADP	IN	_	_	_	_	_
46	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
47	5	5	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
48	'	'	PUNCT	``	_	_	_	_	SpaceAfter=No
49	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
50	flanking	flank	VERB	VBG	VerbForm=Ger	_	_	_	_
51	region	region	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
52	,	,	PUNCT	,	_	_	_	_	_
53	and	and	CCONJ	CC	_	_	_	_	_
54	localized	localize	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
55	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
56	IRF	IRF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
57	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
58	2	2	NUM	CD	NumType=Card	_	_	_	_
59	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
60	on	on	ADP	IN	_	_	_	_	_
61	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
62	chromosome	chromosome	NOUN	NN	Number=Sing	_	_	_	_
63	4	4	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
64	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 42
# text = The IRF-2 promoter region contains a CpG island, with several GC boxes, a putative NF-kappa B-binding site, and a CAAT box, but no TATA box.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	IRF	IRF	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
3	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
4	2	2	NUM	CD	NumType=Card	_	_	_	_
5	promoter	promoter	NOUN	NN	Number=Sing	_	_	_	_
6	region	region	NOUN	NN	Number=Sing	_	_	_	_
7	contains	contain	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
8	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
9	CpG	CpG	PROPN	NNP	Number=Sing	_	_	_	_
10	island	island	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
11	,	,	PUNCT	,	_	_	_	_	_
12	with	with	ADP	IN	_	_	_	_	_
13	several	several	ADJ	JJ	Degree=Pos	_	_	_	_
14	GC	Gc	NOUN	NN	Number=Sing	_	_	_	_
15	boxes	box	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
16	,	,	PUNCT	,	_	_	_	_	_
17	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
18	putative	putative	ADJ	JJ	Degree=Pos	_	_	_	_
19	NF	Nf	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
20	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
21	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_
22	B	b	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
23	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
24	binding	binding	VERB	VBG	VerbForm=Ger	_	_	_	_
25	site	site	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
26	,	,	PUNCT	,	_	_	_	_	_
27	and	and	CCONJ	CC	_	_	_	_	_
28	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
29	CAAT	Caat	NOUN	NN	Number=Sing	_	_	_	_
30	box	box	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
31	,	,	PUNCT	,	_	_	_	_	_
32	but	but	CCONJ	CC	_	_	_	_	_
33	no	no	DET	DT	_	_	_	_	_
34	TATA	TATa	NOUN	NN	Number=Sing	_	_	_	_
35	box	box	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
36	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 43
# text = When the promoter region was linked with a heterologous reporter gene, we found that the promoter region is inducible by both interferons (interferon-alpha and -gamma) and interferon regulatory factor
1	When	when	ADV	WRB	PronType=Int	_	_	_	_
2	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
3	promoter	promoter	NOUN	NN	Number=Sing	_	_	_	_
4	region	region	NOUN	NN	Number=Sing	_	_	_	_
5	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
6	linked	link	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
7	with	with	ADP	IN	_	_	_	_	_
8	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
9	heterologous	heterologous	ADJ	JJ	Degree=Pos	_	_	_	_
10	reporter	reporter	NOUN	NN	Number=Sing	_	_	_	_
11	gene	gene	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
12	,	,	PUNCT	,	_	_	_	_	_
13	we	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
14	found	find	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
15	that	that	SCONJ	IN	_	_	_	_	_
16	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
17	promoter	promoter	NOUN	NN	Number=Sing	_	_	_	_
18	region	region	NOUN	NN	Number=Sing	_	_	_	_
19	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
20	inducible	inducible	ADJ	JJ	Degree=Pos	_	_	_	_
21	by	by	ADP	IN	_	_	_	_	_
22	both	both	CCONJ	CC	_	_	_	_	_
23	interferons	interferon	NOUN	NNS	Number=Plur	_	_	_	_
24	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
25	interferon	interferon	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
26	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
27	alpha	alpha	NOUN	NN	Number=Sing	_	_	_	_
28	and	and	CCONJ	CC	_	_	_	_	_
29	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
30	gamma	gamma	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
31	)	)	PUNCT	-RRB-	_	_	_	_	_
32	and	and	CCONJ	CC	_	_	_	_	_
33	interferon	interferon	ADP	IN	_	_	_	_	_
34	regulatory	regulatory	ADJ	JJ	Degree=Pos	_	_	_	_
35	factor	factor	NOUN	NN	Number=Sing	_	_	_	_

# sent_id = 44
# text = 1.
1	1	1	X	LS	_	_	_	_	SpaceAfter=No
2	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 45
# text = The region which induced these inductions was identified as being confined to 40 nucleotides 5' to the major transcriptional initiation site by testing a series of clones with truncated promoter of IRF-2.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	region	region	NOUN	NN	Number=Sing	_	_	_	_
3	which	which	PRON	WDT	PronType=Rel	_	_	_	_
4	induced	induce	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
5	these	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
6	inductions	induction	NOUN	NNS	Number=Plur	_	_	_	_
7	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
8	identified	identify	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
9	as	as	SCONJ	IN	_	_	_	_	_
10	being	be	AUX	VBG	VerbForm=Ger	_	_	_	_
11	confined	confine	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
12	to	to	ADP	IN	_	_	_	_	_
13	40	40	NUM	CD	NumType=Card	_	_	_	_
14	nucleotides	nucleotide	NOUN	NNS	Number=Plur	_	_	_	_
15	5	5	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
16	'	'	NOUN	NNS	Number=Plur	_	_	_	_
17	to	to	ADP	IN	_	_	_	_	_
18	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
19	major	major	ADJ	JJ	Degree=Pos	_	_	_	_
20	transcriptional	transcriptional	ADJ	JJ	Degree=Pos	_	_	_	_
21	initiation	initiation	NOUN	NN	Number=Sing	_	_	_	_
22	site	site	NOUN	NN	Number=Sing	_	_	_	_
23	by	by	SCONJ	IN	_	_	_	_	_
24	testing	teste	VERB	VBG	VerbForm=Ger	_	_	_	_
25	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
26	series	series	NOUN	NN	Number=Sing	_	_	_	_
27	of	of	ADP	IN	_	_	_	_	_
28	clones	clone	NOUN	NNS	Number=Plur	_	_	_	_
29	with	with	ADP	IN	_	_	_	_	_
30	truncated	truncate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
31	promoter	promoter	NOUN	NN	Number=Sing	_	_	_	_
32	of	of	ADP	IN	_	_	_	_	_
33	IRF	IRF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
34	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
35	2	2	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
36	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 46
# text = This region contains elements which are shared with the transcriptional enhancers of other genes including interferon regulatory factor 1, interferon beta, and interferon-inducible genes.
1	This	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
2	region	region	NOUN	NN	Number=Sing	_	_	_	_
3	contains	contain	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
4	elements	element	NOUN	NNS	Number=Plur	_	_	_	_
5	which	which	PRON	WDT	PronType=Rel	_	_	_	_
6	are	be	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
7	shared	share	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
8	with	with	ADP	IN	_	_	_	_	_
9	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
10	transcriptional	transcriptional	ADJ	JJ	Degree=Pos	_	_	_	_
11	enhancers	enhancer	NOUN	NNS	Number=Plur	_	_	_	_
12	of	of	ADP	IN	_	_	_	_	_
13	other	other	ADJ	JJ	Degree=Pos	_	_	_	_
14	genes	gene	NOUN	NNS	Number=Plur	_	_	_	_
15	including	include	VERB	VBG	VerbForm=Ger	_	_	_	_
16	interferon	interferon	ADP	IN	_	_	_	_	_
17	regulatory	regulatory	ADJ	JJ	Degree=Pos	_	_	_	_
18	factor	factor	NOUN	NN	Number=Sing	_	_	_	_
19	1	1	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
20	,	,	PUNCT	,	_	_	_	_	_
21	interferon	interferon	ADP	IN	_	_	_	_	_
22	beta	beta	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
23	,	,	PUNCT	,	_	_	_	_	_
24	and	and	CCONJ	CC	_	_	_	_	_
25	interferon	interferon	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
26	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
27	inducible	inducible	ADJ	JJ	Degree=Pos	_	_	_	_
28	genes	gene	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
29	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 47
# text = These data suggest that interferon regulatory factor 1 not only triggers the activation of the interferon signal transduction pathway, but also may play a role in limiting the duration of this response by activating the transcription of IRF-2.
1	These	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
2	data	data	NOUN	NN	Number=Sing	_	_	_	_
3	suggest	suggest	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
4	that	that	PRON	DT	Number=Sing|PronType=Dem	_	_	_	_
5	interferon	interferon	ADP	IN	_	_	_	_	_
6	regulatory	regulatory	ADJ	JJ	Degree=Pos	_	_	_	_
7	factor	factor	NOUN	NN	Number=Sing	_	_	_	_
8	1	1	NUM	CD	NumType=Card	_	_	_	_
9	not	not	ADV	RB	_	_	_	_	_
10	only	only	ADV	RB	_	_	_	_	_
11	triggers	trigger	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
12	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
13	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
14	of	of	ADP	IN	_	_	_	_	_
15	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
16	interferon	interferon	ADJ	JJ	Degree=Pos	_	_	_	_
17	signal	signal	NOUN	NN	Number=Sing	_	_	_	_
18	transduction	transduction	NOUN	NN	Number=Sing	_	_	_	_
19	pathway	pathway	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
20	,	,	PUNCT	,	_	_	_	_	_
21	but	but	CCONJ	CC	_	_	_	_	_
22	also	also	ADV	RB	_	_	_	_	_
23	may	may	AUX	MD	VerbForm=Fin	_	_	_	_
24	play	play	VERB	VB	VerbForm=Inf	_	_	_	_
25	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
26	role	role	NOUN	NN	Number=Sing	_	_	_	_
27	in	in	SCONJ	IN	_	_	_	_	_
28	limiting	limite	VERB	VBG	VerbForm=Ger	_	_	_	_
29	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
30	duration	duration	NOUN	NN	Number=Sing	_	_	_	_
31	of	of	ADP	IN	_	_	_	_	_
32	this	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
33	response	response	NOUN	NN	Number=Sing	_	_	_	_
34	by	by	SCONJ	IN	_	_	_	_	_
35	activating	activate	VERB	VBG	VerbForm=Ger	_	_	_	_
36	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
37	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
38	of	of	ADP	IN	_	_	_	_	_
39	IRF	IRF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
40	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
41	2	2	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
42	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 48
# text = Document 00300221 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	00300221	00300221	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 49
# text = IL-10 inhibits nuclear factor-kappa B/Rel nuclear activity in CD3-stimulated human peripheral T lymphocytes.
1	IL	Il	INTJ	UH	_	_	_	_	SpaceAfter=No
2	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
3	10	10	NUM	CD	NumType=Card	_	_	_	_
4	inhibits	inhibit	NOUN	NNS	Number=Plur	_	_	_	_
5	nuclear	nuclear	ADJ	JJ	Degree=Pos	_	_	_	_
6	factor	factor	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
7	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
8	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_
9	B	b	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
10	/	/	PUNCT	,	_	_	_	_	SpaceAfter=No
11	Rel	Rel	PROPN	NNP	Number=Sing	_	_	_	_
12	nuclear	nuclear	ADJ	JJ	Degree=Pos	_	_	_	_
13	activity	activity	NOUN	NN	Number=Sing	_	_	_	_
14	in	in	ADP	IN	_	_	_	_	_
15	CD3	CD3	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
16	-	-	PUNCT	:	_	_	_	_	SpaceAfter=No
17	stimulated	stimulate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
18	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
19	peripheral	peripheral	ADJ	JJ	Degree=Pos	_	_	_	_
20	T	t	PROPN	NNP	Number=Sing	_	_	_	_
21	lymphocytes	lymphocyte	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
22	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 50
# text = IL-10 markedly reduces nuclear factor (NF)-kappa B/Rel nuclear activity induced in PBMC by stimulation with the anti-CD3 mAb OKT3.
1	IL	Il	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
2	-	-	SYM	SYM	_	_	_	_	SpaceAfter=No
3	10	10	NUM	CD	NumType=Card	_	_	_	_
4	markedly	markedly	ADV	RB	_	_	_	_	_
5	reduces	reduce	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
6	nuclear	nuclear	ADJ	JJ	Degree=Pos	_	_	_	_
7	factor	factor	NOUN	NN	Number=Sing	_	_	_	_
8	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
9	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
10	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
11	-	-	PUNCT	:	_	_	_	_	SpaceAfter=No
12	kappa	kappa	PROPN	NNP	Number=Sing	_	_	_	_
13	B	B	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
14	/	/	PUNCT	,	_	_	_	_	SpaceAfter=No
15	Rel	Rel	PROPN	NNP	Number=Sing	_	_	_	_
16	nuclear	nuclear	ADJ	JJ	Degree=Pos	_	_	_	_
17	activity	activity	NOUN	NN	Number=Sing	_	_	_	_
18	induced	induce	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
19	in	in	ADP	IN	_	_	_	_	_
20	PBMC	PBMC	PROPN	NNP	Number=Sing	_	_	_	_
21	by	by	ADP	IN	_	_	_	_	_
22	stimulation	stimulation	NOUN	NN	Number=Sing	_	_	_	_
23	with	with	ADP	IN	_	_	_	_	_
24	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
25	anti-CD3	anti-CD3	NOUN	NN	Number=Sing	_	_	_	_
26	mAb	mAb	NOUN	NN	Number=Sing	_	_	_	_
27	OKT3	OKT3	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
28	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 51
# text = The inhibition is exerted specifically on the NF-kappa B/Rel activation induced by mAb OKT3, and not that produced by PMA.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	inhibition	inhibition	NOUN	NN	Number=Sing	_	_	_	_
3	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
4	exerted	exert	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
5	specifically	specifically	ADV	RB	_	_	_	_	_
6	on	on	ADP	IN	_	_	_	_	_
7	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
8	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
9	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
10	kappa	kappa	PROPN	NNP	Number=Sing	_	_	_	_
11	B	b	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
12	/	/	PUNCT	,	_	_	_	_	SpaceAfter=No
13	Rel	Rel	PROPN	NNP	Number=Sing	_	_	_	_
14	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
15	induced	induce	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
16	by	by	ADP	IN	_	_	_	_	_
17	mAb	mAb	PROPN	NNP	Number=Sing	_	_	_	_
18	OKT3	OKT3	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
19	,	,	PUNCT	,	_	_	_	_	_
20	and	and	CCONJ	CC	_	_	_	_	_
21	not	not	ADV	RB	_	_	_	_	_
22	that	that	SCONJ	IN	_	_	_	_	_
23	produced	produce	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
24	by	by	ADP	IN	_	_	_	_	_
25	PMA	PMA	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
26	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 52
# text = As judged by supershifting the DNA-protein complexes with Abs recognizing specific components of the NF-kappa B/Rel protein family, the p50/p65 (Rel A) heterodimeric form of NF-kappa B is primarily affected.
1	As	as	SCONJ	IN	_	_	_	_	_
2	judged	judge	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
3	by	by	SCONJ	IN	_	_	_	_	_
4	supershifting	supershift	VERB	VBG	VerbForm=Ger	_	_	_	_
5	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
6	DNA	dna	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
7	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
8	protein	protein	NOUN	NN	Number=Sing	_	_	_	_
9	complexes	complex	NOUN	NNS	Number=Plur	_	_	_	_
10	with	with	ADP	IN	_	_	_	_	_
11	Abs	Abs	PROPN	NNPS	Number=Plur	_	_	_	_
12	recognizing	recognize	VERB	VBG	VerbForm=Ger	_	_	_	_
13	specific	specific	ADJ	JJ	Degree=Pos	_	_	_	_
14	components	component	NOUN	NNS	Number=Plur	_	_	_	_
15	of	of	ADP	IN	_	_	_	_	_
16	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
17	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
18	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
19	kappa	kappa	PROPN	NNP	Number=Sing	_	_	_	_
20	B	b	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
21	/	/	PUNCT	,	_	_	_	_	SpaceAfter=No
22	Rel	Rel	PROPN	NNP	Number=Sing	_	_	_	_
23	protein	protein	NOUN	NN	Number=Sing	_	_	_	_
24	family	family	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
25	,	,	PUNCT	,	_	_	_	_	_
26	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
27	p50	p50	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
28	/	/	PUNCT	,	_	_	_	_	SpaceAfter=No
29	p65	p65	NOUN	NN	Number=Sing	_	_	_	_
30	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
31	Rel	Rel	NOUN	NN	Number=Sing	_	_	_	_
32	A	a	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
33	)	)	PUNCT	-RRB-	_	_	_	_	_
34	heterodimeric	heterodimeric	ADJ	JJ	Degree=Pos	_	_	_	_
35	form	form	NOUN	NN	Number=Sing	_	_	_	_
36	of	of	ADP	IN	_	_	_	_	_
37	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
38	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
39	kappa	kappa	PROPN	NNP	Number=Sing	_	_	_	_
40	B	b	PROPN	NNP	Number=Sing	_	_	_	_
41	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
42	primarily	primarily	ADV	RB	_	_	_	_	_
43	affected	affect	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	SpaceAfter=No
44	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 53
# text = The maximal effect is observed at the IL-10 concentration of 20 U/ml.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	maximal	maximal	ADJ	JJ	Degree=Pos	_	_	_	_
3	effect	effect	NOUN	NN	Number=Sing	_	_	_	_
4	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
5	observed	observe	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
6	at	at	ADP	IN	_	_	_	_	_
7	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
8	IL	Il	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
9	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
10	10	10	NUM	CD	NumType=Card	_	_	_	_
11	concentration	concentration	NOUN	NN	Number=Sing	_	_	_	_
12	of	of	ADP	IN	_	_	_	_	_
13	20	20	NUM	CD	NumType=Card	_	_	_	_
14	U/ml	u/ml	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
15	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 54
# text = IL-10 inhibitory activity is exerted on T lymphocytes and is mediated by monocytes.
1	IL	Il	INTJ	UH	_	_	_	_	SpaceAfter=No
2	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
3	10	10	NUM	CD	NumType=Card	_	_	_	_
4	inhibitory	inhibitory	NOUN	NN	Number=Sing	_	_	_	_
5	activity	activity	NOUN	NN	Number=Sing	_	_	_	_
6	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
7	exerted	exert	VERB	VBN	Tense=Past|Typo=Yes|VerbForm=Part|Voice=Pass	_	_	_	_
8	on	on	ADP	IN	_	_	_	_	_
9	T	t	PROPN	NNP	Number=Sing	_	_	_	_
10	lymphocytes	lymphocyte	NOUN	NNS	Number=Plur	_	_	_	_
11	and	and	CCONJ	CC	_	_	_	_	_
12	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
13	mediated	mediate	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
14	by	by	ADP	IN	_	_	_	_	_
15	monocytes	monocyte	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
16	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 55
# text = Indeed, monocytes pretreated with IL-10 are able so inhibit NF-kappa B nuclear activity in purified T lymphocytes stimulated with OKT3.
1	Indeed	indeed	ADV	RB	_	_	_	_	SpaceAfter=No
2	,	,	PUNCT	,	_	_	_	_	_
3	monocytes	monocyte	NOUN	NNS	Number=Plur	_	_	_	_
4	pretreated	pretreate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
5	with	with	ADP	IN	_	_	_	_	_
6	IL	Il	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
7	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
8	10	10	NUM	CD	NumType=Card	_	_	_	_
9	are	be	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
10	able	able	ADJ	JJ	Degree=Pos	_	_	_	_
11	so	so	ADV	RB	_	_	_	_	_
12	inhibit	inhibit	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
13	NF	Nf	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
14	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
15	kappa	kappa	PROPN	NNP	Number=Sing	_	_	_	_
16	B	b	PROPN	NNP	Number=Sing	_	_	_	_
17	nuclear	nuclear	ADJ	JJ	Degree=Pos	_	_	_	_
18	activity	activity	NOUN	NN	Number=Sing	_	_	_	_
19	in	in	ADP	IN	_	_	_	_	_
20	purified	purified	ADJ	JJ	Degree=Pos	_	_	_	_
21	T	t	PROPN	NNP	Number=Sing	_	_	_	_
22	lymphocytes	lymphocyte	NOUN	NNS	Number=Plur	_	_	_	_
23	stimulated	stimulate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
24	with	with	ADP	IN	_	_	_	_	_
25	OKT3	OKT3	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
26	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 56
# text = Soluble factors do not appear to be involved in the mechanism of inhibition.
1	Soluble	Soluble	ADJ	JJ	Degree=Pos	_	_	_	_
2	factors	factor	NOUN	NNS	Number=Plur	_	_	_	_
3	do	do	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
4	not	not	PART	RB	_	_	_	_	_
5	appear	appear	VERB	VB	VerbForm=Inf	_	_	_	_
6	to	to	PART	TO	_	_	_	_	_
7	be	be	AUX	VB	VerbForm=Inf	_	_	_	_
8	involved	involved	ADJ	JJ	Degree=Pos	_	_	_	_
9	in	in	ADP	IN	_	_	_	_	_
10	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
11	mechanism	mechanism	NOUN	NN	Number=Sing	_	_	_	_
12	of	of	ADP	IN	_	_	_	_	_
13	inhibition	inhibition	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
14	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 57
# text = On the other hand, the up-regulation of CD80
1	On	on	ADP	IN	_	_	_	_	_
2	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
3	other	other	ADJ	JJ	Degree=Pos	_	_	_	_
4	hand	hand	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
5	,	,	PUNCT	,	_	_	_	_	_
6	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
7	up	up	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
8	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
9	regulation	regulation	NOUN	NN	Number=Sing	_	_	_	_
10	of	of	ADP	IN	_	_	_	_	_
11	CD80	CD80	PROPN	NNP	Number=Sing	_	_	_	_

# sent_id = 58
# text = Ag, found on monocytes obtained from PBMC incubated with OKT3, is not detected after addition of IL-10, and the anti-CD28 mAb CLB-CD28/1 restores the NF-kappa B/Rel nuclear activity in IL-10-inhibited lymphocytes.
1	Ag	ag	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
2	,	,	PUNCT	,	_	_	_	_	_
3	found	find	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
4	on	on	ADP	IN	_	_	_	_	_
5	monocytes	monocyte	NOUN	NNS	Number=Plur	_	_	_	_
6	obtained	obtaine	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
7	from	from	ADP	IN	_	_	_	_	_
8	PBMC	PBMC	PROPN	NNP	Number=Sing	_	_	_	_
9	incubated	incubate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
10	with	with	ADP	IN	_	_	_	_	_
11	OKT3	OKT3	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
12	,	,	PUNCT	,	_	_	_	_	_
13	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
14	not	not	PART	RB	_	_	_	_	_
15	detected	detect	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
16	after	after	ADP	IN	_	_	_	_	_
17	addition	addition	NOUN	NN	Number=Sing	_	_	_	_
18	of	of	ADP	IN	_	_	_	_	_
19	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
20	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
21	10	10	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
22	,	,	PUNCT	,	_	_	_	_	_
23	and	and	CCONJ	CC	_	_	_	_	_
24	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
25	anti-CD28	anti-CD28	PROPN	NNP	Number=Sing	_	_	_	_
26	mAb	mAb	PROPN	NNP	Number=Sing	_	_	_	_
27	CLB	CLB	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
28	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
29	CD28/1	CD28/1	PROPN	NNP	Number=Sing	_	_	_	_
30	restores	restore	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
31	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
32	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
33	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
34	kappa	kappa	PROPN	NNP	Number=Sing	_	_	_	_
35	B	b	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
36	/	/	PUNCT	,	_	_	_	_	SpaceAfter=No
37	Rel	Rel	PROPN	NNP	Number=Sing	_	_	_	_
38	nuclear	nuclear	ADJ	JJ	Degree=Pos	_	_	_	_
39	activity	activity	NOUN	NN	Number=Sing	_	_	_	_
40	in	in	ADP	IN	_	_	_	_	_
41	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
42	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
43	10	10	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
44	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
45	inhibited	inhibit	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
46	lymphocytes	lymphocyte	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
47	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 59
# text = Therefore, the NF-kappa B/Rel inhibition might be ascribed to a lack of cooperation between accessory cells and T lymphocytes, resulting from down-regulation of a costimulatory molecule, such as CD80, produced by IL-10 on activated monocytes.
1	Therefore	therefore	ADV	RB	_	_	_	_	SpaceAfter=No
2	,	,	PUNCT	,	_	_	_	_	_
3	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
4	NF	NF	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
5	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
6	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_
7	B	b	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
8	/	/	PUNCT	,	_	_	_	_	SpaceAfter=No
9	Rel	Rel	NOUN	NN	Number=Sing	_	_	_	_
10	inhibition	inhibition	NOUN	NN	Number=Sing	_	_	_	_
11	might	might	AUX	MD	VerbForm=Fin	_	_	_	_
12	be	be	AUX	VB	VerbForm=Inf	_	_	_	_
13	ascribed	ascribe	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
14	to	to	ADP	IN	_	_	_	_	_
15	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
16	lack	lack	NOUN	NN	Number=Sing	_	_	_	_
17	of	of	ADP	IN	_	_	_	_	_
18	cooperation	cooperation	NOUN	NN	Number=Sing	_	_	_	_
19	between	between	ADP	IN	_	_	_	_	_
20	accessory	accessory	ADJ	JJ	Degree=Pos	_	_	_	_
21	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
22	and	and	CCONJ	CC	_	_	_	_	_
23	T	t	NOUN	NN	Number=Sing	_	_	_	_
24	lymphocytes	lymphocyte	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
25	,	,	PUNCT	,	_	_	_	_	_
26	resulting	result	VERB	VBG	VerbForm=Ger	_	_	_	_
27	from	from	ADP	IN	_	_	_	_	_
28	down	down	ADV	RB	_	_	_	_	SpaceAfter=No
29	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
30	regulation	regulation	NOUN	NN	Number=Sing	_	_	_	_
31	of	of	ADP	IN	_	_	_	_	_
32	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
33	costimulatory	costimulatory	ADJ	JJ	Degree=Pos	_	_	_	_
34	molecule	molecule	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
35	,	,	PUNCT	,	_	_	_	_	_
36	such	such	ADJ	JJ	Degree=Pos	_	_	_	_
37	as	as	ADP	IN	_	_	_	_	_
38	CD80	CD80	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
39	,	,	PUNCT	,	_	_	_	_	_
40	produced	produce	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
41	by	by	ADP	IN	_	_	_	_	_
42	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
43	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
44	10	10	NUM	CD	NumType=Card	_	_	_	_
45	on	on	ADP	IN	_	_	_	_	_
46	activated	activate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
47	monocytes	monocyte	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
48	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 60
# text = Our results demonstrate that IL-10 can inhibit the induction of NF-kappa B/Rel nuclear activity in CD3-stimulated T lymphocytes.
1	Our	we	PRON	PRP$	Number=Plur|Person=1|Poss=Yes|PronType=Prs	_	_	_	_
2	results	result	NOUN	NNS	Number=Plur	_	_	_	_
3	demonstrate	demonstrate	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
4	that	that	SCONJ	IN	_	_	_	_	_
5	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
6	-	-	SYM	SYM	_	_	_	_	SpaceAfter=No
7	10	10	NUM	CD	NumType=Card	_	_	_	_
8	can	can	AUX	MD	VerbForm=Fin	_	_	_	_
9	inhibit	inhibit	VERB	VB	VerbForm=Inf	_	_	_	_
10	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
11	induction	induction	NOUN	NN	Number=Sing	_	_	_	_
12	of	of	ADP	IN	_	_	_	_	_
13	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
14	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
15	kappa	kappa	PROPN	NNP	Number=Sing	_	_	_	_
16	B	b	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
17	/	/	PUNCT	,	_	_	_	_	SpaceAfter=No
18	Rel	Rel	PROPN	NNP	Number=Sing	_	_	_	_
19	nuclear	nuclear	ADJ	JJ	Degree=Pos	_	_	_	_
20	activity	activity	NOUN	NN	Number=Sing	_	_	_	_
21	in	in	ADP	IN	_	_	_	_	_
22	CD3	CD3	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
23	-	-	PUNCT	:	_	_	_	_	SpaceAfter=No
24	stimulated	stimulate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
25	T	t	PROPN	NNP	Number=Sing	_	_	_	_
26	lymphocytes	lymphocyte	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
27	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 61
# text = Since inappropriate activation of kappa B-driven genes has a physiopathologic role in a number of diseases, such as HIV infection, our findings support the possibility of using this cytokine to suppress an undesirable activation of these transcription factors.
1	Since	since	ADP	IN	_	_	_	_	_
2	inappropriate	inappropriate	ADJ	JJ	Degree=Pos	_	_	_	_
3	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
4	of	of	ADP	IN	_	_	_	_	_
5	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_
6	B	b	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
7	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
8	driven	drive	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
9	genes	gene	NOUN	NNS	Number=Plur	_	_	_	_
10	has	have	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
11	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
12	physiopathologic	physiopathologic	ADJ	JJ	Degree=Pos	_	_	_	_
13	role	role	NOUN	NN	Number=Sing	_	_	_	_
14	in	in	ADP	IN	_	_	_	_	_
15	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
16	number	number	NOUN	NN	Number=Sing	_	_	_	_
17	of	of	ADP	IN	_	_	_	_	_
18	diseases	disease	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
19	,	,	PUNCT	,	_	_	_	_	_
20	such	such	ADJ	JJ	Degree=Pos	_	_	_	_
21	as	as	ADP	IN	_	_	_	_	_
22	HIV	Hiv	NOUN	NN	Number=Sing	_	_	_	_
23	infection	infection	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
24	,	,	PUNCT	,	_	_	_	_	_
25	our	we	PRON	PRP$	Number=Plur|Person=1|Poss=Yes|PronType=Prs	_	_	_	_
26	findings	finding	NOUN	NNS	Number=Plur	_	_	_	_
27	support	support	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
28	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
29	possibility	possibility	NOUN	NN	Number=Sing	_	_	_	_
30	of	of	SCONJ	IN	_	_	_	_	_
31	using	use	VERB	VBG	VerbForm=Ger	_	_	_	_
32	this	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
33	cytokine	cytokine	NOUN	NN	Number=Sing	_	_	_	_
34	to	to	PART	TO	_	_	_	_	_
35	suppress	suppress	VERB	VB	VerbForm=Inf	_	_	_	_
36	an	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
37	undesirable	undesirable	ADJ	JJ	Degree=Pos	_	_	_	_
38	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
39	of	of	ADP	IN	_	_	_	_	_
40	these	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
41	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
42	factors	factor	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
43	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 62
# text = Document 00300223 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	00300223	00300223	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 63
# text = TNFalpha cooperates with the protein kinase A pathway to synergistically increase HIV-1 LTR transcription via downstream TRE-like cAMP response elements.
1	TNFalpha	TNFalpha	PROPN	NNP	Number=Sing	_	_	_	_
2	cooperates	cooperate	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
3	with	with	ADP	IN	_	_	_	_	_
4	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
5	protein	protein	NOUN	NN	Number=Sing	_	_	_	_
6	kinase	kinase	NOUN	NN	Number=Sing	_	_	_	_
7	A	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
8	pathway	pathway	NOUN	NN	Number=Sing	_	_	_	_
9	to	to	PART	TO	_	_	_	_	_
10	synergistically	synergistically	ADV	RB	_	_	_	_	_
11	increase	increase	VERB	VB	VerbForm=Inf	_	_	_	_
12	HIV	Hiv	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
13	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
14	1	1	NUM	CD	NumType=Card	_	_	_	_
15	LTR	Ltr	NOUN	NN	Number=Sing	_	_	_	_
16	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
17	via	via	ADP	IN	_	_	_	_	_
18	downstream	downstream	ADJ	JJ	Degree=Pos	_	_	_	_
19	TRE	tre	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
20	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
21	like	like	ADJ	JJ	Degree=Pos	_	_	_	_
22	cAMP	camp	NOUN	NN	Number=Sing	_	_	_	_
23	response	response	NOUN	NN	Number=Sing	_	_	_	_
24	elements	element	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
25	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 64
# text = Activating protein-1 (AP-1) binding TPA responsive elements (TRE) are located downstream of the transcription initiation site in the U5 region of the HIV-1 long terminal repeat (LTR).
1	Activating	Activat	VERB	VBG	VerbForm=Ger	_	_	_	_
2	protein	protein	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
3	-1	-1	NUM	CD	NumType=Card	_	_	_	_
4	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
5	AP	ap	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
6	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
7	1	1	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
8	)	)	PUNCT	-RRB-	_	_	_	_	_
9	binding	bind	VERB	VBG	VerbForm=Ger	_	_	_	_
10	TPA	Tpa	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
11	responsive	responsive	ADJ	JJ	Degree=Pos	_	_	_	_
12	elements	element	NOUN	NNS	Number=Plur	_	_	_	_
13	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
14	TRE	Tre	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
15	)	)	PUNCT	-RRB-	_	_	_	_	_
16	are	be	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
17	located	locate	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
18	downstream	downstream	NOUN	NN	Number=Sing	_	_	_	_
19	of	of	ADP	IN	_	_	_	_	_
20	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
21	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
22	initiation	initiation	NOUN	NN	Number=Sing	_	_	_	_
23	site	site	NOUN	NN	Number=Sing	_	_	_	_
24	in	in	ADP	IN	_	_	_	_	_
25	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
26	U5	U5	PROPN	NNP	Number=Sing	_	_	_	_
27	region	region	NOUN	NN	Number=Sing	_	_	_	_
28	of	of	ADP	IN	_	_	_	_	_
29	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
30	HIV	Hiv	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
31	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
32	1	1	NUM	CD	NumType=Card	_	_	_	_
33	long	long	ADJ	JJ	Degree=Pos	_	_	_	_
34	terminal	terminal	NOUN	NN	Number=Sing	_	_	_	_
35	repeat	repeat	NOUN	NN	Number=Sing	_	_	_	_
36	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
37	LTR	LTR	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
38	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
39	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 65
# text = These downstream sequence elements, termed DSE, can bind both AP-1 and CREB/ATF transcription factors.
1	These	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
2	downstream	downstream	ADJ	JJ	Degree=Pos	_	_	_	_
3	sequence	sequence	NOUN	NN	Number=Sing	_	_	_	_
4	elements	element	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
5	,	,	PUNCT	,	_	_	_	_	_
6	termed	term	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
7	DSE	Dse	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
8	,	,	PUNCT	,	_	_	_	_	_
9	can	can	AUX	MD	VerbForm=Fin	_	_	_	_
10	bind	bind	VERB	VB	VerbForm=Inf	_	_	_	_
11	both	both	CCONJ	CC	_	_	_	_	_
12	AP	ap	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
13	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
14	1	1	NUM	CD	NumType=Card	_	_	_	_
15	and	and	CCONJ	CC	_	_	_	_	_
16	CREB	Creb	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
17	/	/	PUNCT	,	_	_	_	_	SpaceAfter=No
18	ATF	Atf	PROPN	NNP	Number=Sing	_	_	_	_
19	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
20	factors	factor	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
21	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 66
# text = Recently, we demonstrated that the DSE are also cAMP-responsive elements (CRE), since they mediated activation signals elicited by cholera toxin (Ctx), a potent activator of the cAMP-dependent protein kinase A (PKA) signal transduction pathway.
1	Recently	recently	ADV	RB	_	_	_	_	SpaceAfter=No
2	,	,	PUNCT	,	_	_	_	_	_
3	we	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
4	demonstrated	demonstrate	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
5	that	that	SCONJ	IN	_	_	_	_	_
6	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
7	DSE	Dse	NOUN	NN	Number=Sing	_	_	_	_
8	are	be	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
9	also	also	ADV	RB	_	_	_	_	_
10	cAMP	camp	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
11	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
12	responsive	responsive	ADJ	JJ	Degree=Pos	_	_	_	_
13	elements	element	NOUN	NNS	Number=Plur	_	_	_	_
14	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
15	CRE	CRE	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
16	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
17	,	,	PUNCT	,	_	_	_	_	_
18	since	since	SCONJ	IN	_	_	_	_	_
19	they	they	PRON	PRP	Case=Nom|Number=Plur|Person=3|PronType=Prs	_	_	_	_
20	mediated	mediate	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
21	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
22	signals	signal	NOUN	NNS	Number=Plur	_	_	_	_
23	elicited	elicit	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
24	by	by	ADP	IN	_	_	_	_	_
25	cholera	cholera	NOUN	NN	Number=Sing	_	_	_	_
26	toxin	toxin	NOUN	NN	Number=Sing	_	_	_	_
27	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
28	Ctx	Ctx	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
29	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
30	,	,	PUNCT	,	_	_	_	_	_
31	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
32	potent	potent	ADJ	JJ	Degree=Pos	_	_	_	_
33	activator	activator	NOUN	NN	Number=Sing	_	_	_	_
34	of	of	ADP	IN	_	_	_	_	_
35	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
36	cAMP	camp	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
37	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
38	dependent	dependent	ADJ	JJ	Degree=Pos	_	_	_	_
39	protein	protein	NOUN	NN	Number=Sing	_	_	_	_
40	kinase	kinase	NOUN	NN	Number=Sing	_	_	_	_
41	A	A	PROPN	NNP	Number=Sing	_	_	_	_
42	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
43	PKA	PKA	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
44	)	)	PUNCT	-RRB-	_	_	_	_	_
45	signal	signal	NOUN	NN	Number=Sing	_	_	_	_
46	transduction	transduction	NOUN	NN	Number=Sing	_	_	_	_
47	pathway	pathway	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
48	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 67
# text = In the present study, we demonstrate that the HIV-1 DSE can mediate the transcriptional synergy elicited by the combination of Ctx and TNFalpha.
1	In	in	ADP	IN	_	_	_	_	_
2	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
3	present	present	ADJ	JJ	Degree=Pos	_	_	_	_
4	study	study	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
5	,	,	PUNCT	,	_	_	_	_	_
6	we	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
7	demonstrate	demonstrate	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
8	that	that	SCONJ	IN	_	_	_	_	_
9	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
10	HIV	Hiv	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
11	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
12	1	1	NUM	CD	NumType=Card	_	_	_	_
13	DSE	Dse	NOUN	NN	Number=Sing	_	_	_	_
14	can	can	AUX	MD	VerbForm=Fin	_	_	_	_
15	mediate	mediate	VERB	VB	VerbForm=Inf	_	_	_	_
16	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
17	transcriptional	transcriptional	ADJ	JJ	Degree=Pos	_	_	_	_
18	synergy	synergy	NOUN	NN	Number=Sing	_	_	_	_
19	elicited	elicit	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
20	by	by	ADP	IN	_	_	_	_	_
21	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
22	combination	combination	NOUN	NN	Number=Sing	_	_	_	_
23	of	of	ADP	IN	_	_	_	_	_
24	Ctx	Ctx	PROPN	NNP	Number=Sing	_	_	_	_
25	and	and	CCONJ	CC	_	_	_	_	_
26	TNFalpha	TNFalpha	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
27	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 68
# text = Ctx combined with TNFalpha or IL-1beta to produce a synergistic increase in p24 antigen production in U1 promonocytic cells.
1	Ctx	Ctx	NOUN	NN	Number=Sing	_	_	_	_
2	combined	combine	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
3	with	with	ADP	IN	_	_	_	_	_
4	TNFalpha	TNFalpha	PROPN	NNP	Number=Sing	_	_	_	_
5	or	or	CCONJ	CC	_	_	_	_	_
6	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
7	-1	-1	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
8	beta	beta	NOUN	NN	Number=Sing	_	_	_	_
9	to	to	PART	TO	_	_	_	_	_
10	produce	produce	VERB	VB	VerbForm=Inf	_	_	_	_
11	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
12	synergistic	synergistic	ADJ	JJ	Degree=Pos	_	_	_	_
13	increase	increase	NOUN	NN	Number=Sing	_	_	_	_
14	in	in	ADP	IN	_	_	_	_	_
15	p24	p24	NUM	CD	NumType=Card	_	_	_	_
16	antigen	antigen	ADJ	JJ	Degree=Pos	_	_	_	_
17	production	production	NOUN	NN	Number=Sing	_	_	_	_
18	in	in	ADP	IN	_	_	_	_	_
19	U1	U1	NUM	CD	NumType=Card	_	_	_	_
20	promonocytic	promonocytic	ADJ	JJ	Degree=Pos	_	_	_	_
21	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
22	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 69
# text = Transfection studies of LTR reporter constructs indicated that mutation of the DSE sites abrogated the LTR-mediated synergy induced by Ctx and TNFalpha, whereas the synergy induced by Ctx and IL-1beta was unaffected, suggesting TNFalpha and IL-1beta cooperate differently with the cAMP/PKA activation pathway to induce HIV-1 expression in U1 cells.
1	Transfection	Transfection	NOUN	NN	Number=Sing	_	_	_	_
2	studies	study	NOUN	NNS	Number=Plur	_	_	_	_
3	of	of	ADP	IN	_	_	_	_	_
4	LTR	Ltr	ADJ	JJ	Degree=Pos	_	_	_	_
5	reporter	reporter	NOUN	NN	Number=Sing	_	_	_	_
6	constructs	construct	NOUN	NNS	Number=Plur	_	_	_	_
7	indicated	indicate	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
8	that	that	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
9	mutation	mutation	NOUN	NN	Number=Sing	_	_	_	_
10	of	of	ADP	IN	_	_	_	_	_
11	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
12	DSE	DSE	PROPN	NNP	Number=Sing	_	_	_	_
13	sites	site	NOUN	NNS	Number=Plur	_	_	_	_
14	abrogated	abrogate	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
15	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
16	LTR-	ltr-	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
17	mediated	mediate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
18	synergy	synergy	NOUN	NN	Number=Sing	_	_	_	_
19	induced	induce	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
20	by	by	ADP	IN	_	_	_	_	_
21	Ctx	Ctx	PROPN	NNP	Number=Sing	_	_	_	_
22	and	and	CCONJ	CC	_	_	_	_	_
23	TNFalpha	TNFalpha	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
24	,	,	PUNCT	,	_	_	_	_	_
25	whereas	whereas	SCONJ	IN	_	_	_	_	_
26	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
27	synergy	synergy	NOUN	NN	Number=Sing	_	_	_	_
28	induced	induce	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
29	by	by	ADP	IN	_	_	_	_	_
30	Ctx	Ctx	PROPN	NNP	Number=Sing	_	_	_	_
31	and	and	CCONJ	CC	_	_	_	_	_
32	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
33	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
34	1	1	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
35	beta	beta	NOUN	NN	Number=Sing	_	_	_	_
36	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
37	unaffected	unaffected	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
38	,	,	PUNCT	,	_	_	_	_	_
39	suggesting	suggest	VERB	VBG	VerbForm=Ger	_	_	_	_
40	TNFalpha	TNFalpha	PROPN	NNP	Number=Sing	_	_	_	_
41	and	and	CCONJ	CC	_	_	_	_	_
42	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
43	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
44	1	1	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
45	beta	beta	NOUN	NN	Number=Sing	_	_	_	_
46	cooperate	cooperate	NOUN	NN	Number=Sing	_	_	_	_
47	differently	differently	ADV	RB	_	_	_	_	_
48	with	with	ADP	IN	_	_	_	_	_
49	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
50	cAMP	camp	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
51	/	/	PUNCT	,	_	_	_	_	SpaceAfter=No
52	PKA	PKa	NOUN	NN	Number=Sing	_	_	_	_
53	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
54	pathway	pathway	NOUN	NN	Number=Sing	_	_	_	_
55	to	to	PART	TO	_	_	_	_	_
56	induce	induce	VERB	VB	VerbForm=Inf	_	_	_	_
57	HIV	Hiv	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
58	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
59	1	1	NUM	CD	NumType=Card	_	_	_	_
60	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
61	in	in	ADP	IN	_	_	_	_	_
62	U1	U1	PROPN	NNP	Number=Sing	_	_	_	_
63	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
64	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 70
# text = Because the DSE are also TRE sites, we assessed the effect of the agonist combinations on AP-1-dependent transcription.
1	Because	because	SCONJ	IN	_	_	_	_	_
2	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
3	DSE	Dse	NOUN	NN	Number=Sing	_	_	_	_
4	are	be	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
5	also	also	ADV	RB	_	_	_	_	_
6	TRE	Tre	ADJ	JJ	Degree=Pos	_	_	_	_
7	sites	site	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
8	,	,	PUNCT	,	_	_	_	_	_
9	we	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
10	assessed	assess	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
11	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
12	effect	effect	NOUN	NN	Number=Sing	_	_	_	_
13	of	of	ADP	IN	_	_	_	_	_
14	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
15	agonist	agonist	ADJ	JJ	Degree=Pos	_	_	_	_
16	combinations	combination	NOUN	NNS	Number=Plur	_	_	_	_
17	on	on	ADP	IN	_	_	_	_	_
18	AP	ap	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
19	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
20	1	1	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
21	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
22	dependent	dependent	ADJ	JJ	Degree=Pos	_	_	_	_
23	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
24	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 71
# text = TNFalpha as well as IL-1beta cooperated with Ctx to produce a synergistic activation of AP-1-mediated transcription.
1	TNFalpha	TNFalpha	PROPN	NNP	Number=Sing	_	_	_	_
2	as	as	ADV	RB	_	_	_	_	_
3	well	well	ADV	RB	Degree=Pos	_	_	_	_
4	as	as	ADP	IN	_	_	_	_	_
5	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
6	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
7	1	1	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
8	beta	beta	NOUN	NN	Number=Sing	_	_	_	_
9	cooperated	cooperate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
10	with	with	ADP	IN	_	_	_	_	_
11	Ctx	Ctx	PROPN	NNP	Number=Sing	_	_	_	_
12	to	to	PART	TO	_	_	_	_	_
13	produce	produce	VERB	VB	VerbForm=Inf	_	_	_	_
14	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
15	synergistic	synergistic	ADJ	JJ	Degree=Pos	_	_	_	_
16	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
17	of	of	ADP	IN	_	_	_	_	_
18	AP	ap	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
19	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
20	1	1	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
21	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
22	mediated	mediate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
23	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
24	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 72
# text = These data indicate that the TRE-like cAMP-responsive DSE sites within the 5'-untranslated leader can mediate the transcriptional cooperativity between TNFalpha and the cAMP/PKA pathway.
1	These	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
2	data	data	NOUN	NN	Number=Sing	_	_	_	_
3	indicate	indicate	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
4	that	that	SCONJ	IN	_	_	_	_	_
5	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
6	TRE	Tre	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
7	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
8	like	like	ADJ	JJ	Degree=Pos	_	_	_	_
9	cAMP	camp	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
10	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
11	responsive	responsive	ADJ	JJ	Degree=Pos	_	_	_	_
12	DSE	Dse	NOUN	NN	Number=Sing	_	_	_	_
13	sites	site	NOUN	NNS	Number=Plur	_	_	_	_
14	within	within	ADP	IN	_	_	_	_	_
15	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
16	5	5	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
17	'	's	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
18	-	-	SYM	SYM	_	_	_	_	SpaceAfter=No
19	untranslated	untranslated	ADJ	JJ	Degree=Pos	_	_	_	_
20	leader	leader	NOUN	NN	Number=Sing	_	_	_	_
21	can	can	AUX	MD	VerbForm=Fin	_	_	_	_
22	mediate	mediate	VERB	VB	VerbForm=Inf	_	_	_	_
23	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
24	transcriptional	transcriptional	ADJ	JJ	Degree=Pos	_	_	_	_
25	cooperativity	cooperativity	NOUN	NN	Number=Sing	_	_	_	_
26	between	between	ADP	IN	_	_	_	_	_
27	TNFalpha	TNFalpha	PROPN	NNP	Number=Sing	_	_	_	_
28	and	and	CCONJ	CC	_	_	_	_	_
29	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
30	cAMP	camp	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
31	/	/	PUNCT	,	_	_	_	_	SpaceAfter=No
32	PKA	PKa	NOUN	NN	Number=Sing	_	_	_	_
33	pathway	pathway	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
34	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 73
# text = Since the DSE and TRE sites cannot bind CREB/ATF homodimers, we propose a mechanism in which the HIV-1 DSE bind heterodimers composed of both AP-1 and CREB/ATF proteins.
1	Since	since	SCONJ	IN	_	_	_	_	_
2	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
3	DSE	Dse	NOUN	NN	Number=Sing	_	_	_	_
4	and	and	CCONJ	CC	_	_	_	_	_
5	TRE	Tre	NOUN	NN	Number=Sing	_	_	_	_
6	sites	site	NOUN	NNS	Number=Plur	_	_	_	_
7	can	can	AUX	MD	VerbForm=Fin	_	_	_	SpaceAfter=No
8	not	not	PART	RB	_	_	_	_	_
9	bind	bind	VERB	VB	VerbForm=Inf	_	_	_	_
10	CREB	CREB	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
11	/	/	PUNCT	,	_	_	_	_	SpaceAfter=No
12	ATF	ATF	PROPN	NNP	Number=Sing	_	_	_	_
13	homodimers	homodimer	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
14	,	,	PUNCT	,	_	_	_	_	_
15	we	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
16	propose	propose	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
17	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
18	mechanism	mechanism	NOUN	NN	Number=Sing	_	_	_	_
19	in	in	ADP	IN	_	_	_	_	_
20	which	which	PRON	WDT	PronType=Rel	_	_	_	_
21	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
22	HIV	Hiv	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
23	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
24	1	1	NUM	CD	NumType=Card	_	_	_	_
25	DSE	Dse	NOUN	NN	Number=Sing	_	_	_	_
26	bind	bind	ADP	IN	_	_	_	_	_
27	heterodimers	heterodimer	NOUN	NNS	Number=Plur	_	_	_	_
28	composed	compose	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
29	of	of	ADP	IN	_	_	_	_	_
30	both	both	DET	DT	_	_	_	_	_
31	AP	ap	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
32	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
33	1	1	NUM	CD	NumType=Card	_	_	_	_
34	and	and	CCONJ	CC	_	_	_	_	_
35	CREB	CREB	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
36	/	/	PUNCT	,	_	_	_	_	SpaceAfter=No
37	ATF	ATF	PROPN	NNP	Number=Sing	_	_	_	_
38	proteins	protein	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
39	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 74
# text = Copyright 1997 Academic Press.
1	Copyright	copyright	NOUN	NN	Number=Sing	_	_	_	_
2	1997	1997	NUM	CD	NumType=Card	_	_	_	_
3	Academic	academic	PROPN	NNP	Number=Sing	_	_	_	_
4	Press.	Press.	PROPN	NNP	Number=Sing	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 75
# text = Document 00300229 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	00300229	00300229	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 76
# text = Signaling events induced by lipopolysaccharide-activated toll-like receptor
1	Signaling	signal	VERB	VBG	VerbForm=Ger	_	_	_	_
2	events	event	NOUN	NNS	Number=Plur	_	_	_	_
3	induced	induce	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
4	by	by	ADP	IN	_	_	_	_	_
5	lipopolysaccharide	lipopolysaccharide	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
6	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
7	activated	activate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
8	toll	toll	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
9	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
10	like	like	ADJ	JJ	Degree=Pos	_	_	_	_
11	receptor	receptor	NOUN	NN	Number=Sing	_	_	_	_

# sent_id = 77
# text = 2.
1	2	2	X	LS	_	_	_	_	SpaceAfter=No
2	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 78
# text = Human Toll-like receptor 2 (TLR2) is a signaling receptor that responds to LPS and activates NF-kappaB.
1	Human	human	PROPN	NNP	Number=Sing	_	_	_	_
2	Toll	toll	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
3	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
4	like	like	ADJ	JJ	Degree=Pos	_	_	_	_
5	receptor	receptor	NOUN	NN	Number=Sing	_	_	_	_
6	2	2	NUM	CD	NumType=Card	_	_	_	_
7	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
8	TLR2	TLR2	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
9	)	)	PUNCT	-RRB-	_	_	_	_	_
10	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
11	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
12	signaling	signaling	NOUN	NN	Number=Sing	_	_	_	_
13	receptor	receptor	NOUN	NN	Number=Sing	_	_	_	_
14	that	that	PRON	WDT	PronType=Rel	_	_	_	_
15	responds	respond	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
16	to	to	ADP	IN	_	_	_	_	_
17	LPS	LPS	PROPN	NNP	Number=Sing	_	_	_	_
18	and	and	CCONJ	CC	_	_	_	_	_
19	activates	activate	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
20	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
21	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
22	kappaB	kappaB	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
23	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 79
# text = Here, we investigate further the events triggered by TLR2 in response to LPS.
1	Here	here	ADV	RB	PronType=Dem	_	_	_	SpaceAfter=No
2	,	,	PUNCT	,	_	_	_	_	_
3	we	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
4	investigate	investigate	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
5	further	further	ADV	RBR	Degree=Cmp	_	_	_	_
6	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
7	events	event	NOUN	NNS	Number=Plur	_	_	_	_
8	triggered	trigger	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
9	by	by	ADP	IN	_	_	_	_	_
10	TLR2	Tlr2	NOUN	NN	Number=Sing	_	_	_	_
11	in	in	ADP	IN	_	_	_	_	_
12	response	response	NOUN	NN	Number=Sing	_	_	_	_
13	to	to	ADP	IN	_	_	_	_	_
14	LPS	LPS	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
15	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 80
# text = We show that TLR2 associates with the high-affinity LPS binding protein membrane CD14 to serve as an LPS receptor complex, and that LPS treatment enhances the oligomerization of TLR2.
1	We	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
2	show	show	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
3	that	that	SCONJ	IN	_	_	_	_	_
4	TLR2	TLR2	NUM	CD	NumType=Card	_	_	_	_
5	associates	associate	NOUN	NNS	Number=Plur	_	_	_	_
6	with	with	ADP	IN	_	_	_	_	_
7	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
8	high	high	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
9	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
10	affinity	affinity	NOUN	NN	Number=Sing	_	_	_	_
11	LPS	Lp	NOUN	NN	Number=Sing	_	_	_	_
12	binding	bind	VERB	VBG	VerbForm=Ger	_	_	_	_
13	protein	protein	NOUN	NN	Number=Sing	_	_	_	_
14	membrane	membrane	NOUN	NN	Number=Sing	_	_	_	_
15	CD14	CD14	PROPN	NNP	Number=Sing	_	_	_	_
16	to	to	PART	TO	_	_	_	_	_
17	serve	serve	VERB	VB	VerbForm=Inf	_	_	_	_
18	as	as	ADP	IN	_	_	_	_	_
19	an	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
20	LPS	LPS	PROPN	NNP	Number=Sing	_	_	_	_
21	receptor	receptor	NOUN	NN	Number=Sing	_	_	_	_
22	complex	complex	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
23	,	,	PUNCT	,	_	_	_	_	_
24	and	and	CCONJ	CC	_	_	_	_	_
25	that	that	SCONJ	IN	_	_	_	_	_
26	LPS	Lps	PROPN	NNP	Number=Sing	_	_	_	_
27	treatment	treatment	NOUN	NN	Number=Sing	_	_	_	_
28	enhances	enhance	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
29	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
30	oligomerization	oligomerization	NOUN	NN	Number=Sing	_	_	_	_
31	of	of	ADP	IN	_	_	_	_	_
32	TLR2	TLR2	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
33	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 81
# text = Concomitant with receptor oligomerization, the IL-1R-associated kinase (IRAK) is recruited to the TLR2 complex.
1	Concomitant	Concomitant	ADJ	JJ	Degree=Pos	_	_	_	_
2	with	with	ADP	IN	_	_	_	_	_
3	receptor	receptor	NOUN	NN	Number=Sing	_	_	_	_
4	oligomerization	oligomerization	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
5	,	,	PUNCT	,	_	_	_	_	_
6	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
7	IL-	Il-	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
8	1R-	1R-	PUNCT	,	_	_	_	_	SpaceAfter=No
9	associated	associate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
10	kinase	kinase	NOUN	NN	Number=Sing	_	_	_	_
11	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
12	IRAK	IRAK	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
13	)	)	PUNCT	-RRB-	_	_	_	_	_
14	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
15	recruited	recruit	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
16	to	to	ADP	IN	_	_	_	_	_
17	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
18	TLR2	Tlr2	NOUN	NN	Number=Sing	_	_	_	_
19	complex	complex	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
20	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 82
# text = Intracellular deletion variants of TLR2 lacking C-terminal 13 or 141 aa fail to recruit IRAK, which is consistent with the inability of these mutants to transmit LPS cellular signaling.
1	Intracellular	Intracelular	ADJ	JJ	Degree=Pos	_	_	_	_
2	deletion	deletion	NOUN	NN	Number=Sing	_	_	_	_
3	variants	variant	NOUN	NNS	Number=Plur	_	_	_	_
4	of	of	ADP	IN	_	_	_	_	_
5	TLR2	TLR2	NUM	CD	NumType=Card	_	_	_	_
6	lacking	lack	NOUN	NN	Number=Sing	_	_	_	_
7	C-	C-	SYM	SYM	_	_	_	_	SpaceAfter=No
8	terminal	terminal	NOUN	NN	Number=Sing	_	_	_	_
9	13	13	NUM	CD	NumType=Card	_	_	_	_
10	or	or	CCONJ	CC	_	_	_	_	_
11	141	141	NUM	CD	NumType=Card	_	_	_	_
12	aa	a	DET	DT	Typo=Yes	_	_	_	_
13	fail	fail	NOUN	NN	Number=Sing	_	_	_	_
14	to	to	PART	TO	_	_	_	_	_
15	recruit	recruit	VERB	VB	VerbForm=Inf	_	_	_	_
16	IRAK	IRAK	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
17	,	,	PUNCT	,	_	_	_	_	_
18	which	which	PRON	WDT	PronType=Rel	_	_	_	_
19	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
20	consistent	consistent	ADJ	JJ	Degree=Pos	_	_	_	_
21	with	with	ADP	IN	_	_	_	_	_
22	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
23	inability	inability	NOUN	NN	Number=Sing	_	_	_	_
24	of	of	ADP	IN	_	_	_	_	_
25	these	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
26	mutants	mutant	NOUN	NNS	Number=Plur	_	_	_	_
27	to	to	PART	TO	_	_	_	_	_
28	transmit	transmit	VERB	VB	VerbForm=Inf	_	_	_	_
29	LPS	LPS	PROPN	NNP	Number=Sing	_	_	_	_
30	cellular	celular	ADJ	JJ	Degree=Pos	_	_	_	_
31	signaling	signaling	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
32	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 83
# text = Moreover, both deletion mutants could still form complexes with wild-type TLR2 and act in a dominant-negative (DN) fashion to block TLR2-mediated signal transduction.
1	Moreover	moreover	ADV	RB	_	_	_	_	SpaceAfter=No
2	,	,	PUNCT	,	_	_	_	_	_
3	both	both	DET	DT	_	_	_	_	_
4	deletion	deletion	NOUN	NN	Number=Sing	_	_	_	_
5	mutants	mutant	NOUN	NNS	Number=Plur	_	_	_	_
6	could	could	AUX	MD	VerbForm=Fin	_	_	_	_
7	still	still	ADV	RB	_	_	_	_	_
8	form	form	VERB	VB	VerbForm=Inf	_	_	_	_
9	complexes	complexe	NOUN	NNS	Number=Plur	_	_	_	_
10	with	with	ADP	IN	_	_	_	_	_
11	wild	wild	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
12	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
13	type	type	NOUN	NN	Number=Sing	_	_	_	_
14	TLR2	Tlr2	NOUN	NN	Number=Sing	_	_	_	_
15	and	and	CCONJ	CC	_	_	_	_	_
16	act	act	NOUN	NN	Number=Sing	_	_	_	_
17	in	in	ADP	IN	_	_	_	_	_
18	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
19	dominant	dominant	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
20	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
21	negative	negative	ADJ	JJ	Degree=Pos	_	_	_	_
22	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
23	DN	DN	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
24	)	)	PUNCT	-RRB-	_	_	_	_	_
25	fashion	fashion	NOUN	NN	Number=Sing	_	_	_	_
26	to	to	PART	TO	_	_	_	_	_
27	block	block	VERB	VB	VerbForm=Inf	_	_	_	_
28	TLR2	Tlr2	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
29	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
30	mediated	mediate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
31	signal	signal	NOUN	NN	Number=Sing	_	_	_	_
32	transduction	transduction	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
33	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 84
# text = DN constructs of myeloid differentiation protein, IRAK, TNF receptor-associated factor 6, and NF-kappaB-inducing kinase, when coexpressed with TLR2, abrogate TLR2-mediated NF-kappaB activation.
1	DN	Dn	ADJ	JJ	Degree=Pos	_	_	_	_
2	constructs	construct	NOUN	NNS	Number=Plur	_	_	_	_
3	of	of	ADP	IN	_	_	_	_	_
4	myeloid	myeloid	ADJ	JJ	Degree=Pos	_	_	_	_
5	differentiation	differentiation	NOUN	NN	Number=Sing	_	_	_	_
6	protein	protein	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
7	,	,	PUNCT	,	_	_	_	_	_
8	IRAK	IRAK	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
9	,	,	PUNCT	,	_	_	_	_	_
10	TNF	TNF	PROPN	NNP	Number=Sing	_	_	_	_
11	receptor	receptor	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
12	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
13	associated	associate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
14	factor	factor	NOUN	NN	Number=Sing	_	_	_	_
15	6	6	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
16	,	,	PUNCT	,	_	_	_	_	_
17	and	and	CCONJ	CC	_	_	_	_	_
18	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
19	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
20	kappaB	kappaB	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
21	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
22	inducing	induce	VERB	VBG	VerbForm=Ger	_	_	_	_
23	kinase	kinase	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
24	,	,	PUNCT	,	_	_	_	_	_
25	when	when	ADV	WRB	PronType=Int	_	_	_	_
26	coexpressed	coexpress	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
27	with	with	ADP	IN	_	_	_	_	_
28	TLR2	Tlr2	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
29	,	,	PUNCT	,	_	_	_	_	_
30	abrogate	abrogate	ADJ	JJ	Degree=Pos	_	_	_	_
31	TLR2	Tlr2	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
32	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
33	mediated	mediate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
34	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
35	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
36	kappaB	kappaB	PROPN	NNP	Number=Sing	_	_	_	_
37	activation	activation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
38	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 85
# text = These results reveal a conserved signaling pathway for TLR2 and IL-1Rs and suggest a molecular mechanism for the inhibition of TLR2 by DN variants.
1	These	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
2	results	result	NOUN	NNS	Number=Plur	_	_	_	_
3	reveal	reveal	VERB	VB	VerbForm=Inf	_	_	_	_
4	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
5	conserved	conserve	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
6	signaling	signaling	NOUN	NN	Number=Sing	_	_	_	_
7	pathway	pathway	NOUN	NN	Number=Sing	_	_	_	_
8	for	for	ADP	IN	_	_	_	_	_
9	TLR2	Tlr2	NUM	CD	NumType=Card	_	_	_	_
10	and	and	CCONJ	CC	_	_	_	_	_
11	IL	Il	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
12	-1Rs	-1R	PROPN	NNPS	Number=Plur	_	_	_	_
13	and	and	CCONJ	CC	_	_	_	_	_
14	suggest	suggest	VERB	VB	VerbForm=Inf	_	_	_	_
15	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
16	molecular	molecular	ADJ	JJ	Degree=Pos	_	_	_	_
17	mechanism	mechanism	NOUN	NN	Number=Sing	_	_	_	_
18	for	for	ADP	IN	_	_	_	_	_
19	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
20	inhibition	inhibition	NOUN	NN	Number=Sing	_	_	_	_
21	of	of	ADP	IN	_	_	_	_	_
22	TLR2	TLR2	NUM	CD	NumType=Card	_	_	_	_
23	by	by	ADP	IN	_	_	_	_	_
24	DN	Dn	ADJ	JJ	Degree=Pos	_	_	_	_
25	variants	variant	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
26	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 86
# text = Document 00300232 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	00300232	00300232	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 87
# text = The role of p16 in the E2F-dependent thymidine kinase regulation.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	role	role	NOUN	NN	Number=Sing	_	_	_	_
3	of	of	ADP	IN	_	_	_	_	_
4	p16	p16	NUM	CD	NumType=Card	_	_	_	_
5	in	in	ADP	IN	_	_	_	_	_
6	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
7	E2F	E2F	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
8	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
9	dependent	dependent	ADJ	JJ	Degree=Pos	_	_	_	_
10	thymidine	thymidine	NOUN	NN	Number=Sing	_	_	_	_
11	kinase	kinase	NOUN	NN	Number=Sing	_	_	_	_
12	regulation	regulation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
13	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 88
# text = The role of alterations of the MTS1 tumor suppressor gene on chromosome 9p21, which encodes p16, the inhibitor of cyclin-dependent-kinase-4 and 6, in tumorigenesis is not yet clear.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	role	role	NOUN	NN	Number=Sing	_	_	_	_
3	of	of	ADP	IN	_	_	_	_	_
4	alterations	alteration	NOUN	NNS	Number=Plur	_	_	_	_
5	of	of	ADP	IN	_	_	_	_	_
6	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
7	MTS1	MTS1	PROPN	NNP	Number=Sing	_	_	_	_
8	tumor	tumor	NOUN	NN	Number=Sing	_	_	_	_
9	suppressor	suppressor	NOUN	NN	Number=Sing	_	_	_	_
10	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
11	on	on	ADP	IN	_	_	_	_	_
12	chromosome	chromosome	NOUN	NN	Number=Sing	_	_	_	_
13	9p21	9p21	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
14	,	,	PUNCT	,	_	_	_	_	_
15	which	which	PRON	WDT	PronType=Rel	_	_	_	_
16	encodes	encode	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
17	p16	p16	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
18	,	,	PUNCT	,	_	_	_	_	_
19	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
20	inhibitor	inhibitor	NOUN	NN	Number=Sing	_	_	_	_
21	of	of	ADP	IN	_	_	_	_	_
22	cyclin	cyclin	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
23	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
24	dependent	dependent	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
25	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
26	kinase	kinase	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
27	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
28	4	4	NUM	CD	NumType=Card	_	_	_	_
29	and	and	CCONJ	CC	_	_	_	_	_
30	6	6	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
31	,	,	PUNCT	,	_	_	_	_	_
32	in	in	ADP	IN	_	_	_	_	_
33	tumorigenesis	tumorigenesis	PRON	DT	Number=Sing|PronType=Dem	_	_	_	_
34	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
35	not	not	PART	RB	_	_	_	_	_
36	yet	yet	ADV	RB	_	_	_	_	_
37	clear	clear	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
38	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 89
# text = Phosphorylation of the retinoblastoma protein by cyclin-dependent kinases 4 and 6 prevents its interaction with the transcription factor E2F, which subsequently promotes the expression of S phase regulated genes, such as thymidine kinase.
1	Phosphorylation	Phosphorylation	NOUN	NN	Number=Sing	_	_	_	_
2	of	of	ADP	IN	_	_	_	_	_
3	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
4	retinoblastoma	retinoblastoma	NOUN	NN	Number=Sing	_	_	_	_
5	protein	protein	NOUN	NN	Number=Sing	_	_	_	_
6	by	by	ADP	IN	_	_	_	_	_
7	cyclin	cyclin	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
8	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
9	dependent	dependent	ADJ	JJ	Degree=Pos	_	_	_	_
10	kinases	kinase	NOUN	NNS	Number=Plur	_	_	_	_
11	4	4	NUM	CD	NumType=Card	_	_	_	_
12	and	and	CCONJ	CC	_	_	_	_	_
13	6	6	NUM	CD	NumType=Card	_	_	_	_
14	prevents	prevent	NOUN	NNS	Number=Plur	_	_	_	_
15	its	its	PRON	PRP$	Gender=Neut|Number=Sing|Person=3|Poss=Yes|PronType=Prs	_	_	_	_
16	interaction	interaction	NOUN	NN	Number=Sing	_	_	_	_
17	with	with	ADP	IN	_	_	_	_	_
18	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
19	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
20	factor	factor	NOUN	NN	Number=Sing	_	_	_	_
21	E2F	E2F	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
22	,	,	PUNCT	,	_	_	_	_	_
23	which	which	PRON	WDT	PronType=Rel	_	_	_	_
24	subsequently	subsequently	ADV	RB	_	_	_	_	_
25	promotes	promote	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
26	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
27	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
28	of	of	ADP	IN	_	_	_	_	_
29	S	s	PROPN	NNP	Number=Sing	_	_	_	_
30	phase	phase	NOUN	NN	Number=Sing	_	_	_	_
31	regulated	regulate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
32	genes	gene	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
33	,	,	PUNCT	,	_	_	_	_	_
34	such	such	ADJ	JJ	Degree=Pos	_	_	_	_
35	as	as	ADP	IN	_	_	_	_	_
36	thymidine	thymidine	PRON	PRP	_	_	_	_	_
37	kinase	kinase	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
38	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 90
# text = Although a role of p16 in this regulation has been presumed, there is no proof so far that loss of this tumor suppressor gene really affects E2F-mediated regulations.
1	Although	although	SCONJ	IN	_	_	_	_	_
2	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
3	role	role	NOUN	NN	Number=Sing	_	_	_	_
4	of	of	ADP	IN	_	_	_	_	_
5	p16	p16	NUM	CD	NumType=Card	_	_	_	_
6	in	in	ADP	IN	_	_	_	_	_
7	this	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
8	regulation	regulation	NOUN	NN	Number=Sing	_	_	_	_
9	has	have	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
10	been	be	AUX	VBN	Tense=Past|VerbForm=Part	_	_	_	_
11	presumed	presume	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	SpaceAfter=No
12	,	,	PUNCT	,	_	_	_	_	_
13	there	there	PRON	EX	_	_	_	_	_
14	is	be	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
15	no	no	DET	DT	_	_	_	_	_
16	proof	proof	ADJ	JJ	Degree=Pos	_	_	_	_
17	so	so	ADV	RB	_	_	_	_	_
18	far	far	ADV	RB	Degree=Pos	_	_	_	_
19	that	that	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
20	loss	loss	NOUN	NN	Number=Sing	_	_	_	_
21	of	of	ADP	IN	_	_	_	_	_
22	this	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
23	tumor	tumor	NOUN	NN	Number=Sing	_	_	_	_
24	suppressor	suppressor	NOUN	NN	Number=Sing	_	_	_	_
25	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
26	really	really	ADV	RB	_	_	_	_	_
27	affects	affect	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
28	E2F	E2F	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
29	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
30	mediated	mediate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
31	regulations	regulation	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
32	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 91
# text = We investigated the regulation of thymidine kinase in phytohemagglutinin-stimulated normal human lymphocytes and in the p16-negative human acute lymphoblastic leukemia cell lines, MOLT-4 and CEM.
1	We	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
2	investigated	investigate	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
3	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
4	regulation	regulation	NOUN	NN	Number=Sing	_	_	_	_
5	of	of	ADP	IN	_	_	_	_	_
6	thymidine	thymidine	PRON	PRP	_	_	_	_	_
7	kinase	kinase	NOUN	NN	Number=Sing	_	_	_	_
8	in	in	ADP	IN	_	_	_	_	_
9	phytohemagglutinin	phytohemagglutinin	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
10	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
11	stimulated	stimulate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
12	normal	normal	ADJ	JJ	Degree=Pos	_	_	_	_
13	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
14	lymphocytes	lymphocyte	NOUN	NNS	Number=Plur	_	_	_	_
15	and	and	CCONJ	CC	_	_	_	_	_
16	in	in	ADP	IN	_	_	_	_	_
17	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
18	p16	p16	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
19	-negative	-negative	ADJ	JJ	Degree=Pos	_	_	_	_
20	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
21	acute	acute	NOUN	NN	Number=Sing	_	_	_	_
22	lymphoblastic	lymphoblastic	ADJ	JJ	Degree=Pos	_	_	_	_
23	leukemia	leukemia	NOUN	NN	Number=Sing	_	_	_	_
24	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
25	lines	line	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
26	,	,	PUNCT	,	_	_	_	_	_
27	MOLT	Molt	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
28	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
29	4	4	NUM	CD	NumType=Card	_	_	_	_
30	and	and	CCONJ	CC	_	_	_	_	_
31	CEM	CEM	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
32	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 92
# text = Compared to normal lymphocytes, MOLT-4 and CEM cells exhibited an altered cell cycle regulation of thymidine kinase, a much higher intracellular activity of this enzyme, and higher thymidine kinase mRNA expression.
1	Compared	compare	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
2	to	to	ADP	IN	_	_	_	_	_
3	normal	normal	ADJ	JJ	Degree=Pos	_	_	_	_
4	lymphocytes	lymphocyte	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
5	,	,	PUNCT	,	_	_	_	_	_
6	MOLT	Molt	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
7	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
8	4	4	NUM	CD	NumType=Card	_	_	_	_
9	and	and	CCONJ	CC	_	_	_	_	_
10	CEM	CEM	PROPN	NNP	Number=Sing	_	_	_	_
11	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
12	exhibited	exhibit	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
13	an	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
14	altered	alter	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
15	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
16	cycle	cycle	NOUN	NN	Number=Sing	_	_	_	_
17	regulation	regulation	NOUN	NN	Number=Sing	_	_	_	_
18	of	of	ADP	IN	_	_	_	_	_
19	thymidine	thymidine	NOUN	NN	Number=Sing	_	_	_	_
20	kinase	kinase	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
21	,	,	PUNCT	,	_	_	_	_	_
22	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
23	much	much	ADJ	JJ	Degree=Pos	_	_	_	_
24	higher	higher	ADJ	JJR	Degree=Cmp	_	_	_	_
25	intracellular	intracellular	ADJ	JJ	Degree=Pos	_	_	_	_
26	activity	activity	NOUN	NN	Number=Sing	_	_	_	_
27	of	of	ADP	IN	_	_	_	_	_
28	this	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
29	enzyme	enzyme	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
30	,	,	PUNCT	,	_	_	_	_	_
31	and	and	CCONJ	CC	_	_	_	_	_
32	higher	higher	ADV	RBR	Degree=Cmp	_	_	_	_
33	thymidine	thymidine	PRON	PRP	_	_	_	_	_
34	kinase	kinase	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
35	mRNA	mRNa	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
36	expression	expression	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
37	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 93
# text = Transient expression of p16 in normal human lymphocytes caused arrest in G1, but was without effect on the cell growth of MOLT-4 and CEM cells, although all of them express functional retinoblastoma protein.
1	Transient	Transient	ADJ	JJ	Degree=Pos	_	_	_	_
2	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
3	of	of	ADP	IN	_	_	_	_	_
4	p16	p16	NOUN	NN	Number=Sing	_	_	_	_
5	in	in	ADP	IN	_	_	_	_	_
6	normal	normal	ADJ	JJ	Degree=Pos	_	_	_	_
7	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
8	lymphocytes	lymphocyte	NOUN	NNS	Number=Plur	_	_	_	_
9	caused	cause	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
10	arrest	arrest	NOUN	NN	Number=Sing	_	_	_	_
11	in	in	ADP	IN	_	_	_	_	_
12	G1	G1	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
13	,	,	PUNCT	,	_	_	_	_	_
14	but	but	CCONJ	CC	_	_	_	_	_
15	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
16	without	without	ADP	IN	_	_	_	_	_
17	effect	effect	NOUN	NN	Number=Sing	_	_	_	_
18	on	on	ADP	IN	_	_	_	_	_
19	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
20	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
21	growth	growth	NOUN	NN	Number=Sing	_	_	_	_
22	of	of	ADP	IN	_	_	_	_	_
23	MOLT	MOLT	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
24	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
25	4	4	NUM	CD	NumType=Card	_	_	_	_
26	and	and	CCONJ	CC	_	_	_	_	_
27	CEM	CEM	PROPN	NNP	Number=Sing	_	_	_	_
28	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
29	,	,	PUNCT	,	_	_	_	_	_
30	although	although	SCONJ	IN	_	_	_	_	_
31	all	all	DET	DT	_	_	_	_	_
32	of	of	ADP	IN	_	_	_	_	_
33	them	they	PRON	PRP	Case=Acc|Number=Plur|Person=3|PronType=Prs	_	_	_	_
34	express	express	ADJ	JJ	Degree=Pos	_	_	_	_
35	functional	functional	ADJ	JJ	Degree=Pos	_	_	_	_
36	retinoblastoma	retinoblastoma	NOUN	NN	Number=Sing	_	_	_	_
37	protein	protein	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
38	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 94
# text = Nevertheless, in the two leukemia cell lines transient overexpression of p16 reestablished the normal regulation of thymidine kinase, paralleled by an increase of the underphosphorylated form of retinoblastoma protein and decrease of free E2F bound to its motif in the thymidine kinase promoter.
1	Nevertheless	nevertheless	ADV	RB	_	_	_	_	SpaceAfter=No
2	,	,	PUNCT	,	_	_	_	_	_
3	in	in	ADP	IN	_	_	_	_	_
4	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
5	two	two	NUM	CD	NumType=Card	_	_	_	_
6	leukemia	leukemia	NOUN	NN	Number=Sing	_	_	_	_
7	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
8	lines	line	NOUN	NNS	Number=Plur	_	_	_	_
9	transient	transient	ADJ	JJ	Degree=Pos	_	_	_	_
10	overexpression	overexpression	NOUN	NN	Number=Sing	_	_	_	_
11	of	of	ADP	IN	_	_	_	_	_
12	p	p	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
13	16	16	NUM	CD	NumType=Card	_	_	_	_
14	reestablished	reestablish	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
15	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
16	normal	normal	ADJ	JJ	Degree=Pos	_	_	_	_
17	regulation	regulation	NOUN	NN	Number=Sing	_	_	_	_
18	of	of	ADP	IN	_	_	_	_	_
19	thymidine	thymidine	PRON	PRP	_	_	_	_	_
20	kinase	kinase	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
21	,	,	PUNCT	,	_	_	_	_	_
22	paralleled	parallel	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
23	by	by	ADP	IN	_	_	_	_	_
24	an	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
25	increase	increase	NOUN	NN	Number=Sing	_	_	_	_
26	of	of	ADP	IN	_	_	_	_	_
27	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
28	underphosphorylated	underphosphorylated	ADJ	JJ	Degree=Pos	_	_	_	_
29	form	form	NOUN	NN	Number=Sing	_	_	_	_
30	of	of	ADP	IN	_	_	_	_	_
31	retinoblastoma	retinoblastoma	NOUN	NN	Number=Sing	_	_	_	_
32	protein	protein	NOUN	NN	Number=Sing	_	_	_	_
33	and	and	CCONJ	CC	_	_	_	_	_
34	decrease	decrease	NOUN	NN	Number=Sing	_	_	_	_
35	of	of	ADP	IN	_	_	_	_	_
36	free	free	ADJ	JJ	Degree=Pos	_	_	_	_
37	E2	e2	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
38	F	F	PROPN	NNP	Number=Sing	_	_	_	_
39	bound	bound	ADJ	JJ	Degree=Pos	_	_	_	_
40	to	to	ADP	IN	_	_	_	_	_
41	its	its	PRON	PRP$	Gender=Neut|Number=Sing|Person=3|Poss=Yes|PronType=Prs	_	_	_	_
42	motif	motif	NOUN	NN	Number=Sing	_	_	_	_
43	in	in	ADP	IN	_	_	_	_	_
44	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
45	thymidine	thymidine	NOUN	NN	Number=Sing	_	_	_	_
46	kinase	kinase	NOUN	NN	Number=Sing	_	_	_	_
47	promoter	promoter	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
48	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 95
# text = We demonstrate that loss of p16 causes upregulation of this DNA precursor pathway enzyme via activation of E2F by a mechanism involving retinoblastoma protein.
1	We	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
2	demonstrate	demonstrate	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
3	that	that	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
4	loss	loss	NOUN	NN	Number=Sing	_	_	_	_
5	of	of	ADP	IN	_	_	_	_	_
6	p16	p16	NUM	CD	NumType=Card	_	_	_	_
7	causes	cause	NOUN	NNS	Number=Plur	_	_	_	_
8	upregulation	upregulation	NOUN	NN	Number=Sing	_	_	_	_
9	of	of	ADP	IN	_	_	_	_	_
10	this	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
11	DNA	dna	NOUN	NN	Number=Sing	_	_	_	_
12	precursor	precursor	NOUN	NN	Number=Sing	_	_	_	_
13	pathway	pathway	NOUN	NN	Number=Sing	_	_	_	_
14	enzyme	enzyme	NOUN	NN	Number=Sing	_	_	_	_
15	via	via	ADP	IN	_	_	_	_	_
16	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
17	of	of	ADP	IN	_	_	_	_	_
18	E2	E2	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
19	F	F	PROPN	NNP	Number=Sing	_	_	_	_
20	by	by	ADP	IN	_	_	_	_	_
21	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
22	mechanism	mechanism	NOUN	NN	Number=Sing	_	_	_	_
23	involving	involve	VERB	VBG	VerbForm=Ger	_	_	_	_
24	retinoblastoma	retinoblastoma	NOUN	NN	Number=Sing	_	_	_	_
25	protein	protein	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
26	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 96
# text = Document 00300233 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	00300233	00300233	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 97
# text = Modulation of endogenous IL-1 beta and IL-1 receptor antagonist results in opposing effects on HIV expression in chronically infected monocytic cells.
1	Modulation	Modulation	NOUN	NN	Number=Sing	_	_	_	_
2	of	of	ADP	IN	_	_	_	_	_
3	endogenous	endogenous	ADJ	JJ	Degree=Pos	_	_	_	_
4	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
5	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
6	1	1	NUM	CD	NumType=Card	_	_	_	_
7	beta	beta	NOUN	NN	Number=Sing	_	_	_	_
8	and	and	CCONJ	CC	_	_	_	_	_
9	IL	Il	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
10	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
11	1	1	NUM	CD	NumType=Card	_	_	_	_
12	receptor	receptor	NOUN	NN	Number=Sing	_	_	_	_
13	antagonist	antagonist	NOUN	NN	Number=Sing	_	_	_	_
14	results	result	NOUN	NNS	Number=Plur	_	_	_	_
15	in	in	ADP	IN	_	_	_	_	_
16	opposing	oppose	ADJ	JJ	Degree=Pos	_	_	_	_
17	effects	effect	NOUN	NNS	Number=Plur	_	_	_	_
18	on	on	ADP	IN	_	_	_	_	_
19	HIV	Hiv	NOUN	NN	Number=Sing	_	_	_	_
20	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
21	in	in	ADP	IN	_	_	_	_	_
22	chronically	chronically	ADV	RB	_	_	_	_	_
23	infected	infect	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
24	monocytic	monocytic	ADJ	JJ	Degree=Pos	_	_	_	_
25	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
26	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 98
# text = A proportion of HIV-infected individuals experience episodes of localized or systemic bacterial infections caused by Gram-negative bacteria.
1	A	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
2	proportion	proportion	NOUN	NN	Number=Sing	_	_	_	_
3	of	of	ADP	IN	_	_	_	_	_
4	HIV-	HIV-	PUNCT	:	_	_	_	_	SpaceAfter=No
5	infected	infect	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
6	individuals	individual	NOUN	NNS	Number=Plur	_	_	_	_
7	experience	experience	NOUN	NN	Number=Sing	_	_	_	_
8	episodes	episode	NOUN	NNS	Number=Plur	_	_	_	_
9	of	of	ADP	IN	_	_	_	_	_
10	localized	localize	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
11	or	or	CCONJ	CC	_	_	_	_	_
12	systemic	systemic	ADJ	JJ	Degree=Pos	_	_	_	_
13	bacterial	bacterial	ADJ	JJ	Degree=Pos	_	_	_	_
14	infections	infection	NOUN	NNS	Number=Plur	_	_	_	_
15	caused	cause	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
16	by	by	ADP	IN	_	_	_	_	_
17	Gram	Gram	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
18	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
19	negative	negative	ADJ	JJ	Degree=Pos	_	_	_	_
20	bacteria	bacterion	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
21	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 99
# text = Many of the clinical side effects of these infections are associated with the production of proinflammatory cytokines, which are induced primarily by LPS, a constituent of the bacterial cell wall of Gram-negative bacteria.
1	Many	many	ADJ	JJ	Degree=Pos	_	_	_	_
2	of	of	ADP	IN	_	_	_	_	_
3	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
4	clinical	clinical	ADJ	JJ	Degree=Pos	_	_	_	_
5	side	side	NOUN	NN	Number=Sing	_	_	_	_
6	effects	effect	NOUN	NNS	Number=Plur	_	_	_	_
7	of	of	ADP	IN	_	_	_	_	_
8	these	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
9	infections	infection	NOUN	NNS	Number=Plur	_	_	_	_
10	are	be	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
11	associated	associate	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
12	with	with	ADP	IN	_	_	_	_	_
13	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
14	production	production	NOUN	NN	Number=Sing	_	_	_	_
15	of	of	ADP	IN	_	_	_	_	_
16	proinflammatory	proinflammatory	ADJ	JJ	Degree=Pos	_	_	_	_
17	cytokines	cytokine	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
18	,	,	PUNCT	,	_	_	_	_	_
19	which	which	PRON	WDT	PronType=Rel	_	_	_	_
20	are	be	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
21	induced	induce	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
22	primarily	primarily	ADV	RB	_	_	_	_	_
23	by	by	ADP	IN	_	_	_	_	_
24	LPS	LPS	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
25	,	,	PUNCT	,	_	_	_	_	_
26	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
27	constituent	constituent	NOUN	NN	Number=Sing	_	_	_	_
28	of	of	ADP	IN	_	_	_	_	_
29	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
30	bacterial	bacterial	ADJ	JJ	Degree=Pos	_	_	_	_
31	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
32	wall	wall	NOUN	NN	Number=Sing	_	_	_	_
33	of	of	ADP	IN	_	_	_	_	_
34	Gram-	Gram-	SYM	NFP	_	_	_	_	SpaceAfter=No
35	negative	negative	ADJ	JJ	Degree=Pos	_	_	_	_
36	bacteria	bacteria	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
37	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 100
# text = The present study examines the mechanisms involved in LPS-mediated induction of HIV expression in U1 cells, a promonocytic cell line chronically infected with HIV.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	present	present	ADJ	JJ	Degree=Pos	_	_	_	_
3	study	study	NOUN	NN	Number=Sing	_	_	_	_
4	examines	examine	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
5	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
6	mechanisms	mechanism	NOUN	NNS	Number=Plur	_	_	_	_
7	involved	involve	ADJ	JJ	Degree=Pos	_	_	_	_
8	in	in	ADP	IN	_	_	_	_	_
9	LPS	Lps	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
10	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
11	mediated	mediate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
12	induction	induction	NOUN	NN	Number=Sing	_	_	_	_
13	of	of	ADP	IN	_	_	_	_	_
14	HIV	HIV	PROPN	NNP	Number=Sing	_	_	_	_
15	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
16	in	in	ADP	IN	_	_	_	_	_
17	U1	U1	PROPN	NNP	Number=Sing	_	_	_	_
18	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
19	,	,	PUNCT	,	_	_	_	_	_
20	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
21	promonocytic	promonocytic	ADJ	JJ	Degree=Pos	_	_	_	_
22	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
23	line	line	NOUN	NN	Number=Sing	_	_	_	_
24	chronically	chronically	ADV	RB	_	_	_	_	_
25	infected	infect	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
26	with	with	ADP	IN	_	_	_	_	_
27	HIV	HIV	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
28	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 101
# text = Stimulation of U1 cells by LPS alone induced minimal levels of HIV expression, which was significantly enhanced by granulocyte-macrophage colony-stimulating factor (GM-CSF).
1	Stimulation	Stimulation	NOUN	NN	Number=Sing	_	_	_	_
2	of	of	ADP	IN	_	_	_	_	_
3	U1	U1	NUM	CD	NumType=Card	_	_	_	_
4	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
5	by	by	ADP	IN	_	_	_	_	_
6	LPS	LPS	PROPN	NNP	Number=Sing	_	_	_	_
7	alone	alone	ADV	RB	_	_	_	_	_
8	induced	induce	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
9	minimal	minimal	ADJ	JJ	Degree=Pos	_	_	_	_
10	levels	level	NOUN	NNS	Number=Plur	_	_	_	_
11	of	of	ADP	IN	_	_	_	_	_
12	HIV	HIV	PROPN	NNP	Number=Sing	_	_	_	_
13	expression	expression	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
14	,	,	PUNCT	,	_	_	_	_	_
15	which	which	PRON	WDT	PronType=Rel	_	_	_	_
16	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
17	significantly	significantly	ADV	RB	_	_	_	_	_
18	enhanced	enhance	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
19	by	by	ADP	IN	_	_	_	_	_
20	granulocyte	granulocyte	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
21	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
22	macrophage	macrophage	NOUN	NN	Number=Sing	_	_	_	_
23	colony	colony	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
24	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
25	stimulating	stimulating	VERB	VBG	VerbForm=Ger	_	_	_	_
26	factor	factor	NOUN	NN	Number=Sing	_	_	_	_
27	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
28	GM	GM	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
29	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
30	CSF	CSF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
31	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
32	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 102
# text = Costimulation of U1 cells with LPS plus GM-CSF resulted in the accumulation of steady-state levels of HIV RNA; however, only a weak induction of HIV long terminal repeat-driven transcription, which was not associated with the activation of the cellular transcription factor nuclear factor-kappa B, was noted.
1	Costimulation	Costimulation	NOUN	NN	Number=Sing	_	_	_	_
2	of	of	ADP	IN	_	_	_	_	_
3	U1	U1	NUM	CD	NumType=Card	_	_	_	_
4	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
5	with	with	ADP	IN	_	_	_	_	_
6	LPS	LPS	PROPN	NNP	Number=Sing	_	_	_	_
7	plus	plus	CCONJ	CC	_	_	_	_	_
8	GM	GM	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
9	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
10	CSF	CSF	PROPN	NNP	Number=Sing	_	_	_	_
11	resulted	result	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
12	in	in	ADP	IN	_	_	_	_	_
13	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
14	accumulation	accumulation	NOUN	NN	Number=Sing	_	_	_	_
15	of	of	ADP	IN	_	_	_	_	_
16	steady	steady	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
17	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
18	state	state	NOUN	NN	Number=Sing	_	_	_	_
19	levels	level	NOUN	NNS	Number=Plur	_	_	_	_
20	of	of	ADP	IN	_	_	_	_	_
21	HIV	HIV	PROPN	NNP	Number=Sing	_	_	_	_
22	RNA	RNA	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
23	;	;	PUNCT	,	_	_	_	_	_
24	however	however	ADV	RB	_	_	_	_	SpaceAfter=No
25	,	,	PUNCT	,	_	_	_	_	_
26	only	only	ADV	RB	_	_	_	_	_
27	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
28	weak	weak	ADJ	JJ	Degree=Pos	_	_	_	_
29	induction	induction	NOUN	NN	Number=Sing	_	_	_	_
30	of	of	ADP	IN	_	_	_	_	_
31	HIV	HIV	PROPN	NNP	Number=Sing	_	_	_	_
32	long	long	ADJ	JJ	Degree=Pos	_	_	_	_
33	terminal	terminal	NOUN	NN	Number=Sing	_	_	_	_
34	repeat	repeat	VERB	VB	VerbForm=Inf	_	_	_	SpaceAfter=No
35	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
36	driven	drive	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
37	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
38	,	,	PUNCT	,	_	_	_	_	_
39	which	which	PRON	WDT	PronType=Rel	_	_	_	_
40	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
41	not	not	PART	RB	_	_	_	_	_
42	associated	associate	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
43	with	with	ADP	IN	_	_	_	_	_
44	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
45	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
46	of	of	ADP	IN	_	_	_	_	_
47	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
48	cellular	cellular	ADJ	JJ	Degree=Pos	_	_	_	_
49	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
50	factor	factor	NOUN	NN	Number=Sing	_	_	_	_
51	nuclear	nuclear	ADJ	JJ	Degree=Pos	_	_	_	_
52	factor	factor	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
53	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
54	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_
55	B	b	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
56	,	,	PUNCT	,	_	_	_	_	_
57	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
58	noted	note	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	SpaceAfter=No
59	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 103
# text = Costimulation of cells with LPS plus GM-CSF induced the production of proinflammatory cytokines, IL-8, IL-1 beta and IL-6, but not TNF-alpha.
1	Costimulation	Costimulation	NOUN	NN	Number=Sing	_	_	_	_
2	of	of	ADP	IN	_	_	_	_	_
3	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
4	with	with	ADP	IN	_	_	_	_	_
5	LPS	LPS	PROPN	NNP	Number=Sing	_	_	_	_
6	plus	plus	CCONJ	CC	_	_	_	_	_
7	GM	GM	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
8	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
9	CSF	CSF	PROPN	NNP	Number=Sing	_	_	_	_
10	induced	induce	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
11	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
12	production	production	NOUN	NN	Number=Sing	_	_	_	_
13	of	of	ADP	IN	_	_	_	_	_
14	proinflammatory	proinflammatory	ADJ	JJ	Degree=Pos	_	_	_	_
15	cytokines	cytokine	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
16	,	,	PUNCT	,	_	_	_	_	_
17	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
18	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
19	8	8	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
20	,	,	PUNCT	,	_	_	_	_	_
21	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
22	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
23	1	1	NUM	CD	NumType=Card	_	_	_	_
24	beta	beta	NOUN	NN	Number=Sing	_	_	_	_
25	and	and	CCONJ	CC	_	_	_	_	_
26	IL	il	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
27	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
28	6	6	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
29	,	,	PUNCT	,	_	_	_	_	_
30	but	but	CCONJ	CC	_	_	_	_	_
31	not	not	ADV	RB	_	_	_	_	_
32	TNF	TNF	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
33	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
34	alpha	alpha	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
35	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 104
# text = IL-1 receptor antagonist (ra) inhibited LPS enhancement of HIV expression in GM-CSF-stimulated cells, suggesting that endogenous IL-1 was involved in LPS-mediated viral production.
1	IL	Il	INTJ	UH	_	_	_	_	SpaceAfter=No
2	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
3	1	1	NUM	CD	NumType=Card	_	_	_	_
4	receptor	receptor	NOUN	NN	Number=Sing	_	_	_	_
5	antagonist	antagonist	NOUN	NN	Number=Sing	_	_	_	_
6	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
7	ra	ra	X	AFX	_	_	_	_	SpaceAfter=No
8	)	)	PUNCT	-RRB-	_	_	_	_	_
9	inhibited	inhibit	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
10	LPS	LPS	PROPN	NNP	Number=Sing	_	_	_	_
11	enhancement	enhancement	NOUN	NN	Number=Sing	_	_	_	_
12	of	of	ADP	IN	_	_	_	_	_
13	HIV	Hiv	PROPN	NNP	Number=Sing	_	_	_	_
14	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
15	in	in	ADP	IN	_	_	_	_	_
16	GM	GM	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
17	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
18	CSF	CSF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
19	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
20	stimulated	stimulate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
21	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
22	,	,	PUNCT	,	_	_	_	_	_
23	suggesting	suggest	VERB	VBG	VerbForm=Ger	_	_	_	_
24	that	that	SCONJ	IN	_	_	_	_	_
25	endogenous	endogenous	ADJ	JJ	Degree=Pos	_	_	_	_
26	IL	Il	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
27	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
28	1	1	NUM	CD	NumType=Card	_	_	_	_
29	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
30	involved	involved	ADJ	JJ	Degree=Pos	_	_	_	_
31	in	in	ADP	IN	_	_	_	_	_
32	LPS	LPS	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
33	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
34	mediated	mediate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
35	viral	viral	ADJ	JJ	Degree=Pos	_	_	_	_
36	production	production	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
37	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 105
# text = In this regard, anti-inflammatory cytokines inhibited LPS plus GM-CSF-stimulated HIV expression, and this effect closely correlated with inhibition of IL-1 beta release and, in particular, with up-regulation of endogenous IL-1ra production.
1	In	in	ADP	IN	_	_	_	_	_
2	this	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
3	regard	regard	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
4	,	,	PUNCT	,	_	_	_	_	_
5	anti-inflammatory	anti-inflammatory	ADJ	JJ	Degree=Pos	_	_	_	_
6	cytokines	cytokine	NOUN	NNS	Number=Plur	_	_	_	_
7	inhibited	inhibit	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
8	LPS	Lp	NOUN	NNS	Number=Plur	_	_	_	_
9	plus	plus	CCONJ	CC	_	_	_	_	_
10	GM-	GM-	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
11	CSF	CSF	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
12	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
13	stimulated	stimulate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
14	HIV	Hiv	NOUN	NN	Number=Sing	_	_	_	_
15	expression	expression	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
16	,	,	PUNCT	,	_	_	_	_	_
17	and	and	CCONJ	CC	_	_	_	_	_
18	this	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
19	effect	effect	NOUN	NN	Number=Sing	_	_	_	_
20	closely	closely	ADV	RB	_	_	_	_	_
21	correlated	correlate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
22	with	with	ADP	IN	_	_	_	_	_
23	inhibition	inhibition	NOUN	NN	Number=Sing	_	_	_	_
24	of	of	ADP	IN	_	_	_	_	_
25	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
26	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
27	1	1	NUM	CD	NumType=Card	_	_	_	_
28	beta	beta	NOUN	NN	Number=Sing	_	_	_	_
29	release	release	NOUN	NN	Number=Sing	_	_	_	_
30	and	and	CCONJ	CC	_	_	_	_	SpaceAfter=No
31	,	,	PUNCT	,	_	_	_	_	_
32	in	in	ADP	IN	_	_	_	_	_
33	particular	particular	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
34	,	,	PUNCT	,	_	_	_	_	_
35	with	with	ADP	IN	_	_	_	_	_
36	up	up	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
37	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
38	regulation	regulation	NOUN	NN	Number=Sing	_	_	_	_
39	of	of	ADP	IN	_	_	_	_	_
40	endogenous	endogenous	ADJ	JJ	Degree=Pos	_	_	_	_
41	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
42	-1	-1	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
43	ra	ra	NOUN	NN	Number=Sing	_	_	_	_
44	production	production	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
45	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 106
# text = Thus, the balance between an endogenously produced viral inducer (IL-1 beta ) and an inhibitor (IL-1ra) may represent an important pathway leading to modulation of
1	Thus	thus	ADV	RB	_	_	_	_	SpaceAfter=No
2	,	,	PUNCT	,	_	_	_	_	_
3	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
4	balance	balance	NOUN	NN	Number=Sing	_	_	_	_
5	between	between	ADP	IN	_	_	_	_	_
6	an	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
7	endogenously	endogenously	ADV	RB	_	_	_	_	_
8	produced	produce	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
9	viral	viral	ADJ	JJ	Degree=Pos	_	_	_	_
10	inducer	inducer	NOUN	NN	Number=Sing	_	_	_	_
11	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
12	IL	Il	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
13	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
14	1	1	NUM	CD	NumType=Card	_	_	_	_
15	beta	beta	NOUN	NN	Number=Sing	_	_	_	_
16	)	)	PUNCT	-RRB-	_	_	_	_	_
17	and	and	CCONJ	CC	_	_	_	_	_
18	an	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
19	inhibitor	inhibitor	NOUN	NN	Number=Sing	_	_	_	_
20	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
21	IL	Il	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
22	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
23	1ra	1ra	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
24	)	)	PUNCT	-RRB-	_	_	_	_	_
25	may	may	AUX	MD	VerbForm=Fin	_	_	_	_
26	represent	represent	VERB	VB	VerbForm=Inf	_	_	_	_
27	an	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
28	important	important	ADJ	JJ	Degree=Pos	_	_	_	_
29	pathway	pathway	NOUN	NN	Number=Sing	_	_	_	_
30	leading	lead	VERB	VBG	VerbForm=Ger	_	_	_	_
31	to	to	ADP	IN	_	_	_	_	_
32	modulation	modulation	NOUN	NN	Number=Sing	_	_	_	_
33	of	of	ADP	IN	_	_	_	_	_

# sent_id = 107
# text = HIV expression from monocytic cells.
1	HIV	Hiv	NOUN	NN	Number=Sing	_	_	_	_
2	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
3	from	from	ADP	IN	_	_	_	_	_
4	monocytic	monocytic	ADJ	JJ	Degree=Pos	_	_	_	_
5	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
6	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 108
# text = Document 00300235 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	00300235	00300235	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 109
# text = Characterization of peripheral blood T-lymphocytes transduced with HTLV-I Tax mutants with different trans-activating phenotypes.
1	Characterization	Characterization	NOUN	NN	Number=Sing	_	_	_	_
2	of	of	ADP	IN	_	_	_	_	_
3	peripheral	peripheral	ADJ	JJ	Degree=Pos	_	_	_	_
4	blood	blood	NOUN	NN	Number=Sing	_	_	_	_
5	T-	T-	PUNCT	:	_	_	_	_	SpaceAfter=No
6	lymphocytes	lymphocyte	NOUN	NNS	Number=Plur	_	_	_	_
7	transduced	transduce	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
8	with	with	ADP	IN	_	_	_	_	_
9	HTLV	HTLV	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
10	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
11	I	I	PRON	PRP	Case=Nom|Number=Sing|Person=1|PronType=Prs	_	_	_	_
12	Tax	Tax	PROPN	NNP	Number=Sing	_	_	_	_
13	mutants	mutant	NOUN	NNS	Number=Plur	_	_	_	_
14	with	with	ADP	IN	_	_	_	_	_
15	different	different	ADJ	JJ	Degree=Pos	_	_	_	_
16	trans	tran	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
17	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
18	activating	activat	VERB	VBG	VerbForm=Ger	_	_	_	_
19	phenotypes	phenotype	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
20	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 110
# text = Tax1, a transcriptional trans-activator of the Human T-cell leukemia virus type I (HTLV-I), induces the expression of many cellular genes through interaction with at least three distinct cellular transcription factors; CREB/ATF, NF-kappaB, and SRF.
1	Tax1	Tax1	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
2	,	,	PUNCT	,	_	_	_	_	_
3	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
4	transcriptional	transcriptional	ADJ	JJ	Degree=Pos	_	_	_	_
5	trans	tran	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
6	-	-	PUNCT	:	_	_	_	_	SpaceAfter=No
7	activator	activator	NOUN	NN	Number=Sing	_	_	_	_
8	of	of	ADP	IN	_	_	_	_	_
9	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
10	Human	human	ADJ	JJ	Degree=Pos	_	_	_	_
11	T-	t-	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
12	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
13	leukemia	leukemia	NOUN	NN	Number=Sing	_	_	_	_
14	virus	virus	NOUN	NN	Number=Sing	_	_	_	_
15	type	type	NOUN	NN	Number=Sing	_	_	_	_
16	I	I	PRON	PRP	Case=Nom|Number=Sing|Person=1|PronType=Prs	_	_	_	_
17	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
18	HTLV	HTLV	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
19	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
20	I	I	PRON	PRP	Case=Nom|Number=Sing|Person=1|PronType=Prs	_	_	_	SpaceAfter=No
21	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
22	,	,	PUNCT	,	_	_	_	_	_
23	induces	induce	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
24	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
25	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
26	of	of	ADP	IN	_	_	_	_	_
27	many	many	ADJ	JJ	Degree=Pos	_	_	_	_
28	cellular	cellular	ADJ	JJ	Degree=Pos	_	_	_	_
29	genes	gene	NOUN	NNS	Number=Plur	_	_	_	_
30	through	through	ADP	IN	_	_	_	_	_
31	interaction	interaction	NOUN	NN	Number=Sing	_	_	_	_
32	with	with	ADP	IN	_	_	_	_	_
33	at	at	ADV	RB	_	_	_	_	_
34	least	least	ADV	RBS	Degree=Sup	_	_	_	_
35	three	three	NUM	CD	NumType=Card	_	_	_	_
36	distinct	distinct	ADJ	JJ	Degree=Pos	_	_	_	_
37	cellular	cellular	ADJ	JJ	Degree=Pos	_	_	_	_
38	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
39	factors	factor	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
40	;	;	PUNCT	,	_	_	_	_	_
41	CREB	CREB	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
42	/	/	PUNCT	,	_	_	_	_	SpaceAfter=No
43	ATF	ATF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
44	,	,	PUNCT	,	_	_	_	_	_
45	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
46	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
47	kappaB	kappaB	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
48	,	,	PUNCT	,	_	_	_	_	_
49	and	and	CCONJ	CC	_	_	_	_	_
50	SRF	SRF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
51	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 111
# text = This Tax1-induced activation of cellular genes is considered to be a critical event in T-cell transformation by HTLV-I.
1	This	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
2	Tax1	tax1	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
3	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
4	induced	induce	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
5	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
6	of	of	ADP	IN	_	_	_	_	_
7	cellular	cellular	ADJ	JJ	Degree=Pos	_	_	_	_
8	genes	gene	NOUN	NNS	Number=Plur	_	_	_	_
9	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
10	considered	consider	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
11	to	to	PART	TO	_	_	_	_	_
12	be	be	AUX	VB	VerbForm=Inf	_	_	_	_
13	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
14	critical	critical	ADJ	JJ	Degree=Pos	_	_	_	_
15	event	event	NOUN	NN	Number=Sing	_	_	_	_
16	in	in	ADP	IN	_	_	_	_	_
17	T-	t-	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
18	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
19	transformation	transformation	NOUN	NN	Number=Sing	_	_	_	_
20	by	by	ADP	IN	_	_	_	_	_
21	HTLV	HTLV	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
22	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
23	I	I	PRON	PRP	Case=Nom|Number=Sing|Person=1|PronType=Prs	_	_	_	SpaceAfter=No
24	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 112
# text = To elucidate the role of each Tax1-inducible transcriptional pathway in T-cell transformation, we introduced Tax1 mutants with different trans-activating phenotypes into peripheral blood lymphocytes (PBL) by retroviral vectors.
1	To	to	PART	TO	_	_	_	_	_
2	elucidate	elucidate	VERB	VB	VerbForm=Inf	_	_	_	_
3	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
4	role	role	NOUN	NN	Number=Sing	_	_	_	_
5	of	of	ADP	IN	_	_	_	_	_
6	each	each	DET	DT	_	_	_	_	_
7	Tax1	tax1	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
8	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
9	inducible	inducible	ADJ	JJ	Degree=Pos	_	_	_	_
10	transcriptional	transcriptional	ADJ	JJ	Degree=Pos	_	_	_	_
11	pathway	pathway	NOUN	NN	Number=Sing	_	_	_	_
12	in	in	ADP	IN	_	_	_	_	_
13	T-	t-	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
14	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
15	transformation	transformation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
16	,	,	PUNCT	,	_	_	_	_	_
17	we	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
18	introduced	introduce	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
19	Tax1	Tax1	NUM	CD	NumType=Card	_	_	_	_
20	mutants	mutant	NOUN	NNS	Number=Plur	_	_	_	_
21	with	with	ADP	IN	_	_	_	_	_
22	different	different	ADJ	JJ	Degree=Pos	_	_	_	_
23	trans	tran	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
24	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
25	activating	activat	VERB	VBG	VerbForm=Ger	_	_	_	_
26	phenotypes	phenotype	NOUN	NNS	Number=Plur	_	_	_	_
27	into	into	ADP	IN	_	_	_	_	_
28	peripheral	peripheral	ADJ	JJ	Degree=Pos	_	_	_	_
29	blood	blood	NOUN	NN	Number=Sing	_	_	_	_
30	lymphocytes	lymphocyte	NOUN	NNS	Number=Plur	_	_	_	_
31	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
32	PBL	PBL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
33	)	)	PUNCT	-RRB-	_	_	_	_	_
34	by	by	ADP	IN	_	_	_	_	_
35	retroviral	retroviral	ADJ	JJ	Degree=Pos	_	_	_	_
36	vectors	vector	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
37	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 113
# text = Analysis of these PBLs revealed that activation of the NF-kappaB pathway is sufficient to promote the growth response to IL-2.
1	Analysis	analysis	NOUN	NN	Number=Sing	_	_	_	_
2	of	of	ADP	IN	_	_	_	_	_
3	these	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
4	PBLs	PBL	NOUN	NNS	Number=Plur	_	_	_	_
5	revealed	reveal	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
6	that	that	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
7	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
8	of	of	ADP	IN	_	_	_	_	_
9	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
10	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
11	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
12	kappaB	kappaB	PROPN	NNP	Number=Sing	_	_	_	_
13	pathway	pathway	NOUN	NN	Number=Sing	_	_	_	_
14	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
15	sufficient	sufficient	ADJ	JJ	Degree=Pos	_	_	_	_
16	to	to	PART	TO	_	_	_	_	_
17	promote	promote	VERB	VB	VerbForm=Inf	_	_	_	_
18	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
19	growth	growth	NOUN	NN	Number=Sing	_	_	_	_
20	response	response	NOUN	NN	Number=Sing	_	_	_	_
21	to	to	ADP	IN	_	_	_	_	_
22	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
23	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
24	2	2	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
25	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 114
# text = However, for the clonal expansion of CD4+ T-cells, which is a characteristic result of HTLV-I infection, activation of the CREB/ATF and SRF pathways is also required.
1	However	however	ADV	RB	_	_	_	_	SpaceAfter=No
2	,	,	PUNCT	,	_	_	_	_	_
3	for	for	ADP	IN	_	_	_	_	_
4	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
5	clonal	clonal	ADJ	JJ	Degree=Pos	_	_	_	_
6	expansion	expansion	NOUN	NN	Number=Sing	_	_	_	_
7	of	of	ADP	IN	_	_	_	_	_
8	CD4	CD4	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
9	+	+	SYM	SYM	_	_	_	_	_
10	T-	T-	SYM	SYM	_	_	_	_	SpaceAfter=No
11	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
12	,	,	PUNCT	,	_	_	_	_	_
13	which	which	PRON	WDT	PronType=Rel	_	_	_	_
14	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
15	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
16	characteristic	characteristic	ADJ	JJ	Degree=Pos	_	_	_	_
17	result	result	NOUN	NN	Number=Sing	_	_	_	_
18	of	of	ADP	IN	_	_	_	_	_
19	HTLV	HTLV	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
20	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
21	I	I	PRON	PRP	Case=Nom|Number=Sing|Person=1|PronType=Prs	_	_	_	_
22	infection	infection	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
23	,	,	PUNCT	,	_	_	_	_	_
24	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
25	of	of	ADP	IN	_	_	_	_	_
26	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
27	CREB	CREB	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
28	/	/	PUNCT	,	_	_	_	_	SpaceAfter=No
29	ATF	ATF	PROPN	NNP	Number=Sing	_	_	_	_
30	and	and	CCONJ	CC	_	_	_	_	_
31	SRF	SRF	PROPN	NNP	Number=Sing	_	_	_	_
32	pathways	pathways	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
33	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
34	also	also	ADV	RB	_	_	_	_	_
35	required	require	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	SpaceAfter=No
36	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 115
# text = Document 00300238 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	00300238	00300238	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 116
# text = Activation of the Janus kinase 3-STAT5a pathway after CD40 triggering of human monocytes but not of resting B cells.
1	Activation	Activation	NOUN	NN	Number=Sing	_	_	_	_
2	of	of	ADP	IN	_	_	_	_	_
3	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
4	Janus	Janus	PROPN	NNP	Number=Sing	_	_	_	_
5	kinase	kinase	NOUN	NN	Number=Sing	_	_	_	_
6	3	3	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
7	-	-	SYM	SYM	_	_	_	_	SpaceAfter=No
8	STAT5	STAT5	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
9	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
10	pathway	pathway	NOUN	NN	Number=Sing	_	_	_	_
11	after	after	SCONJ	IN	_	_	_	_	_
12	CD40	CD40	PROPN	NNP	Number=Sing	_	_	_	_
13	triggering	triggering	VERB	VBG	VerbForm=Ger	_	_	_	_
14	of	of	ADP	IN	_	_	_	_	_
15	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
16	monocytes	monocyte	NOUN	NNS	Number=Plur	_	_	_	_
17	but	but	CCONJ	CC	_	_	_	_	_
18	not	not	ADV	RB	_	_	_	_	_
19	of	of	SCONJ	IN	_	_	_	_	_
20	resting	rest	VERB	VBG	VerbForm=Ger	_	_	_	_
21	B	b	ADJ	JJ	Degree=Pos	_	_	_	_
22	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
23	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 117
# text = CD40/CD40 ligand interactions play a key role in the immune responses of B lymphocytes, monocytes, and dendritic cells.
1	CD40/CD40	CD40/CD40	NUM	CD	NumType=Card	_	_	_	_
2	ligand	ligand	NOUN	NN	Number=Sing	_	_	_	_
3	interactions	interaction	NOUN	NNS	Number=Plur	_	_	_	_
4	play	play	VERB	VB	VerbForm=Inf	_	_	_	_
5	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
6	key	key	ADJ	JJ	Degree=Pos	_	_	_	_
7	role	role	NOUN	NN	Number=Sing	_	_	_	_
8	in	in	ADP	IN	_	_	_	_	_
9	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
10	immune	immune	ADJ	JJ	Degree=Pos	_	_	_	_
11	responses	response	NOUN	NNS	Number=Plur	_	_	_	_
12	of	of	ADP	IN	_	_	_	_	_
13	B	b	ADJ	JJ	Degree=Pos	_	_	_	_
14	lymphocytes	lymphocyte	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
15	,	,	PUNCT	,	_	_	_	_	_
16	monocytes	monocyte	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
17	,	,	PUNCT	,	_	_	_	_	_
18	and	and	CCONJ	CC	_	_	_	_	_
19	dendritic	dendritic	ADJ	JJ	Degree=Pos	_	_	_	_
20	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
21	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 118
# text = The signal transduction events triggered by cross-linking of the CD40 receptor have been widely studied in B cell lines, but little is known about signaling following CD40 stimulation of monocytes and resting tonsillar B cells.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	signal	signal	NOUN	NN	Number=Sing	_	_	_	_
3	transduction	transduction	NOUN	NN	Number=Sing	_	_	_	_
4	events	event	NOUN	NNS	Number=Plur	_	_	_	_
5	triggered	trigger	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
6	by	by	ADP	IN	_	_	_	_	_
7	cross	cross	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
8	-linking	-linking	NOUN	NN	Number=Sing	_	_	_	_
9	of	of	ADP	IN	_	_	_	_	_
10	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
11	CD40	CD40	PROPN	NNP	Number=Sing	_	_	_	_
12	receptor	receptor	NOUN	NN	Number=Sing	_	_	_	_
13	have	have	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
14	been	be	AUX	VBN	Tense=Past|VerbForm=Part	_	_	_	_
15	widely	widely	ADV	RB	_	_	_	_	_
16	studied	study	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
17	in	in	ADP	IN	_	_	_	_	_
18	B	b	ADJ	JJ	Degree=Pos	_	_	_	_
19	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
20	lines	line	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
21	,	,	PUNCT	,	_	_	_	_	_
22	but	but	CCONJ	CC	_	_	_	_	_
23	little	little	ADJ	JJ	Degree=Pos	_	_	_	_
24	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
25	known	know	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
26	about	about	SCONJ	IN	_	_	_	_	_
27	signaling	signal	VERB	VBG	VerbForm=Ger	_	_	_	_
28	following	follow	VERB	VBG	VerbForm=Ger	_	_	_	_
29	CD40	CD40	NUM	CD	NumType=Card	_	_	_	_
30	stimulation	stimulation	NOUN	NN	Number=Sing	_	_	_	_
31	of	of	ADP	IN	_	_	_	_	_
32	monocytes	monocyte	NOUN	NNS	Number=Plur	_	_	_	_
33	and	and	CCONJ	CC	_	_	_	_	_
34	resting	rest	VERB	VBG	VerbForm=Ger	_	_	_	_
35	tonsillar	tonsillar	NOUN	NN	Number=Sing	_	_	_	_
36	B	b	ADJ	JJ	Degree=Pos	_	_	_	_
37	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
38	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 119
# text = Therefore, we studied the CD40 pathway in highly purified human monocytes and resting B cells.
1	Therefore	therefore	ADV	RB	_	_	_	_	SpaceAfter=No
2	,	,	PUNCT	,	_	_	_	_	_
3	we	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
4	studied	study	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
5	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
6	CD40	CD40	PROPN	NNP	Number=Sing	_	_	_	_
7	pathway	pathway	NOUN	NN	Number=Sing	_	_	_	_
8	in	in	ADP	IN	_	_	_	_	_
9	highly	highly	ADV	RB	_	_	_	_	_
10	purified	purified	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
11	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
12	monocytes	monocyte	NOUN	NNS	Number=Plur	_	_	_	_
13	and	and	CCONJ	CC	_	_	_	_	_
14	resting	rest	VERB	VBG	VerbForm=Ger	_	_	_	_
15	B	b	ADJ	JJ	Degree=Pos	_	_	_	_
16	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
17	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 120
# text = After CD40 triggering, a similar activation of the NF-kappaB (but not of the AP-1) transcription factor complex occurred in both cell preparations.
1	After	after	SCONJ	IN	_	_	_	_	_
2	CD40	CD40	PROPN	NNP	Number=Sing	_	_	_	_
3	triggering	triggering	VERB	VBG	VerbForm=Ger	_	_	_	SpaceAfter=No
4	,	,	PUNCT	,	_	_	_	_	_
5	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
6	similar	similar	ADJ	JJ	Degree=Pos	_	_	_	_
7	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
8	of	of	ADP	IN	_	_	_	_	_
9	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
10	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
11	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
12	kappaB	kappaB	PROPN	NNP	Number=Sing	_	_	_	_
13	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
14	but	but	CCONJ	CC	_	_	_	_	_
15	not	not	PART	RB	_	_	_	_	_
16	of	of	ADP	IN	_	_	_	_	_
17	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
18	AP	ap	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
19	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
20	1	1	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
21	)	)	PUNCT	-RRB-	_	_	_	_	_
22	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
23	factor	factor	NOUN	NN	Number=Sing	_	_	_	_
24	complex	complex	NOUN	NN	Number=Sing	_	_	_	_
25	occurred	occur	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
26	in	in	ADP	IN	_	_	_	_	_
27	both	both	DET	DT	_	_	_	_	_
28	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
29	preparations	preparation	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
30	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 121
# text = However, the components of the NF-kappaB complexes were different in monocytes and B cells, because p50 is part of the NF-kappaB complex induced by CD40 triggering in both monocytes and B cells, whereas p65 was only induced in B cells.
1	However	however	ADV	RB	_	_	_	_	SpaceAfter=No
2	,	,	PUNCT	,	_	_	_	_	_
3	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
4	components	component	NOUN	NNS	Number=Plur	_	_	_	_
5	of	of	ADP	IN	_	_	_	_	_
6	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
7	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
8	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
9	kappaB	kappaB	PROPN	NNP	Number=Sing	_	_	_	_
10	complexes	complexe	NOUN	NNS	Number=Plur	_	_	_	_
11	were	be	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
12	different	different	ADJ	JJ	Degree=Pos	_	_	_	_
13	in	in	ADP	IN	_	_	_	_	_
14	monocytes	monocyte	NOUN	NNS	Number=Plur	_	_	_	_
15	and	and	CCONJ	CC	_	_	_	_	_
16	B	b	ADJ	JJ	Degree=Pos	_	_	_	_
17	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
18	,	,	PUNCT	,	_	_	_	_	_
19	because	because	SCONJ	IN	_	_	_	_	_
20	p50	p50	NOUN	NN	Number=Sing	_	_	_	_
21	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
22	part	part	NOUN	NN	Number=Sing	_	_	_	_
23	of	of	ADP	IN	_	_	_	_	_
24	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
25	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
26	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
27	kappaB	kappaB	PROPN	NNP	Number=Sing	_	_	_	_
28	complex	complex	NOUN	NN	Number=Sing	_	_	_	_
29	induced	induce	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
30	by	by	ADP	IN	_	_	_	_	_
31	CD40	CD40	PROPN	NNP	Number=Sing	_	_	_	_
32	triggering	triggere	VERB	VBG	VerbForm=Ger	_	_	_	_
33	in	in	ADP	IN	_	_	_	_	_
34	both	both	DET	DT	_	_	_	_	_
35	monocytes	monocyte	NOUN	NNS	Number=Plur	_	_	_	_
36	and	and	CCONJ	CC	_	_	_	_	_
37	B	b	ADJ	JJ	Degree=Pos	_	_	_	_
38	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
39	,	,	PUNCT	,	_	_	_	_	_
40	whereas	whereas	SCONJ	IN	_	_	_	_	_
41	p65	p65	NOUN	NN	Number=Sing	_	_	_	_
42	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
43	only	only	ADV	RB	_	_	_	_	_
44	induced	induce	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
45	in	in	ADP	IN	_	_	_	_	_
46	B	b	ADJ	JJ	Degree=Pos	_	_	_	_
47	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
48	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 122
# text = In contrast, although the Janus kinase 3 tyrosine kinase was associated with CD40 molecules in both monocytes and resting B cells, Janus kinase 3 phosphorylation induction was observed only in CD40-activated monocytes, with subsequent induction of STAT5a DNA binding activity in the nucleus.
1	In	in	ADP	IN	_	_	_	_	_
2	contrast	contrast	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
3	,	,	PUNCT	,	_	_	_	_	_
4	although	although	SCONJ	IN	_	_	_	_	_
5	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
6	Janus	Janus	PROPN	NNP	Number=Sing	_	_	_	_
7	kinase	kinase	NOUN	NN	Number=Sing	_	_	_	_
8	3	3	NUM	CD	NumType=Card	_	_	_	_
9	tyrosine	tyrosine	NOUN	NN	Number=Sing	_	_	_	_
10	kinase	kinase	NOUN	NN	Number=Sing	_	_	_	_
11	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
12	associated	associate	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
13	with	with	ADP	IN	_	_	_	_	_
14	CD40	CD40	NUM	CD	NumType=Card	_	_	_	_
15	molecules	molecule	NOUN	NNS	Number=Plur	_	_	_	_
16	in	in	ADP	IN	_	_	_	_	_
17	both	both	DET	DT	_	_	_	_	_
18	monocytes	monocyte	NOUN	NNS	Number=Plur	_	_	_	_
19	and	and	CCONJ	CC	_	_	_	_	_
20	resting	rest	VERB	VBG	VerbForm=Ger	_	_	_	_
21	B	b	ADJ	JJ	Degree=Pos	_	_	_	_
22	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
23	,	,	PUNCT	,	_	_	_	_	_
24	Janus	Janus	PROPN	NNP	Number=Sing	_	_	_	_
25	kinase	kinase	NOUN	NN	Number=Sing	_	_	_	_
26	3	3	NUM	CD	NumType=Card	_	_	_	_
27	phosphorylation	phosphorylation	NOUN	NN	Number=Sing	_	_	_	_
28	induction	induction	NOUN	NN	Number=Sing	_	_	_	_
29	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
30	observed	observe	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
31	only	only	ADV	RB	_	_	_	_	_
32	in	in	ADP	IN	_	_	_	_	_
33	CD40	CD40	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
34	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
35	activated	activate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
36	monocytes	monocyte	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
37	,	,	PUNCT	,	_	_	_	_	_
38	with	with	ADP	IN	_	_	_	_	_
39	subsequent	subsequent	ADJ	JJ	Degree=Pos	_	_	_	_
40	induction	induction	NOUN	NN	Number=Sing	_	_	_	_
41	of	of	ADP	IN	_	_	_	_	_
42	STAT5	STAT5	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
43	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
44	DNA	dna	NOUN	NN	Number=Sing	_	_	_	_
45	binding	binde	VERB	VBG	VerbForm=Ger	_	_	_	_
46	activity	activity	NOUN	NN	Number=Sing	_	_	_	_
47	in	in	ADP	IN	_	_	_	_	_
48	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
49	nucleus	nucleus	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
50	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 123
# text = These results suggest that the activation signals in human B cells and monocytes differ following CD40 stimulation.
1	These	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
2	results	result	NOUN	NNS	Number=Plur	_	_	_	_
3	suggest	suggest	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
4	that	that	SCONJ	IN	_	_	_	_	_
5	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
6	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
7	signals	signal	NOUN	NNS	Number=Plur	_	_	_	_
8	in	in	ADP	IN	_	_	_	_	_
9	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
10	B	b	ADJ	JJ	Degree=Pos	_	_	_	_
11	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
12	and	and	CCONJ	CC	_	_	_	_	_
13	monocytes	monocyte	NOUN	NNS	Number=Plur	_	_	_	_
14	differ	differ	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
15	following	follow	VERB	VBG	VerbForm=Ger	_	_	_	_
16	CD40	CD40	NUM	CD	NumType=Card	_	_	_	_
17	stimulation	stimulation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
18	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 124
# text = This observation is consistent with the detection of normal CD40-induced monocyte activation in patients with CD40 ligand+ hyper IgM syndrome in whom a defect in CD40-induced
1	This	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
2	observation	observation	NOUN	NN	Number=Sing	_	_	_	_
3	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
4	consistent	consistent	ADJ	JJ	Degree=Pos	_	_	_	_
5	with	with	ADP	IN	_	_	_	_	_
6	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
7	detection	detection	NOUN	NN	Number=Sing	_	_	_	_
8	of	of	ADP	IN	_	_	_	_	_
9	normal	normal	ADJ	JJ	Degree=Pos	_	_	_	_
10	CD40	CD40	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
11	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
12	induced	induce	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
13	monocyte	monocyte	NOUN	NN	Number=Sing	_	_	_	_
14	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
15	in	in	ADP	IN	_	_	_	_	_
16	patients	patient	NOUN	NNS	Number=Plur	_	_	_	_
17	with	with	ADP	IN	_	_	_	_	_
18	CD40	CD40	NUM	CD	NumType=Card	_	_	_	_
19	ligand	ligand	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
20	+	+	SYM	SYM	_	_	_	_	_
21	hyper	hyper	NOUN	NN	Number=Sing	_	_	_	_
22	IgM	Igm	NOUN	NN	Number=Sing	_	_	_	_
23	syndrome	syndrome	NOUN	NN	Number=Sing	_	_	_	_
24	in	in	ADP	IN	_	_	_	_	_
25	whom	whom	PRON	WP	PronType=Rel	_	_	_	_
26	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
27	defect	defect	NOUN	NN	Number=Sing	_	_	_	_
28	in	in	ADP	IN	_	_	_	_	_
29	CD40	CD40	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
30	-induced	-induce	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_

# sent_id = 125
# text = B cell activation has been reported.
1	B	b	ADJ	JJ	Degree=Pos	_	_	_	_
2	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
3	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
4	has	have	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
5	been	be	AUX	VBN	Tense=Past|VerbForm=Part	_	_	_	_
6	reported	report	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	SpaceAfter=No
7	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 126
# text = Document 00300243 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	00300243	00300243	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 127
# text = Identification of an I kappa B alpha-associated protein kinase in a human monocytic cell line and determination of its phosphorylation sites on I kappa B alpha.
1	Identification	identification	NOUN	NN	Number=Sing	_	_	_	_
2	of	of	ADP	IN	_	_	_	_	_
3	an	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
4	I	I	PRON	PRP	Case=Nom|Number=Sing|Person=1|PronType=Prs	_	_	_	_
5	kappa	kappa	X	GW	_	_	_	_	_
6	B	B	X	GW	_	_	_	_	_
7	alpha	alpha	X	GW	_	_	_	_	SpaceAfter=No
8	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
9	associated	associate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
10	protein	protein	NOUN	NN	Number=Sing	_	_	_	_
11	kinase	kinase	NOUN	NN	Number=Sing	_	_	_	_
12	in	in	ADP	IN	_	_	_	_	_
13	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
14	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
15	monocytic	monocytic	ADJ	JJ	Degree=Pos	_	_	_	_
16	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
17	line	line	NOUN	NN	Number=Sing	_	_	_	_
18	and	and	CCONJ	CC	_	_	_	_	_
19	determination	determination	NOUN	NN	Number=Sing	_	_	_	_
20	of	of	ADP	IN	_	_	_	_	_
21	its	its	PRON	PRP$	Gender=Neut|Number=Sing|Person=3|Poss=Yes|PronType=Prs	_	_	_	_
22	phosphorylation	phosphorylation	NOUN	NN	Number=Sing	_	_	_	_
23	sites	site	NOUN	NNS	Number=Plur	_	_	_	_
24	on	on	ADP	IN	_	_	_	_	_
25	I	I	PRON	PRP	Case=Nom|Number=Sing|Person=1|PronType=Prs	_	_	_	_
26	kappa	kappa	PROPN	NNP	Number=Sing	_	_	_	_
27	B	B	PROPN	NNP	Number=Sing	_	_	_	_
28	alpha	alpha	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
29	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 128
# text = Nuclear factor kappa B (NF-kappa B) is stored in the cytoplasm as an inactive form through interaction with I kappa B. Stimulation of cells leads to a rapid phosphorylation of I kappa B alpha, which is presumed to be important for the subsequent degradation.
1	Nuclear	nuclear	ADJ	JJ	Degree=Pos	_	_	_	_
2	factor	factor	NOUN	NN	Number=Sing	_	_	_	_
3	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_
4	B	b	NOUN	NN	Number=Sing	_	_	_	_
5	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
6	NF	Nf	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
7	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
8	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_
9	B	b	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
10	)	)	PUNCT	-RRB-	_	_	_	_	_
11	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
12	stored	store	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
13	in	in	ADP	IN	_	_	_	_	_
14	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
15	cytoplasm	cytoplasm	NOUN	NN	Number=Sing	_	_	_	_
16	as	as	ADP	IN	_	_	_	_	_
17	an	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
18	inactive	inactive	ADJ	JJ	Degree=Pos	_	_	_	_
19	form	form	NOUN	NN	Number=Sing	_	_	_	_
20	through	through	ADP	IN	_	_	_	_	_
21	interaction	interaction	NOUN	NN	Number=Sing	_	_	_	_
22	with	with	ADP	IN	_	_	_	_	_
23	I	I	PRON	PRP	Case=Nom|Number=Sing|Person=1|PronType=Prs	_	_	_	_
24	kappa	kappa	PROPN	NNP	Number=Sing	_	_	_	_
25	B.	B.	PROPN	NNP	Number=Sing	_	_	_	_
26	Stimulation	Stimulation	NOUN	NN	Number=Sing	_	_	_	_
27	of	of	ADP	IN	_	_	_	_	_
28	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
29	leads	lead	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
30	to	to	ADP	IN	_	_	_	_	_
31	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
32	rapid	rapid	ADJ	JJ	Degree=Pos	_	_	_	_
33	phosphorylation	phosphorylation	NOUN	NN	Number=Sing	_	_	_	_
34	of	of	ADP	IN	_	_	_	_	_
35	I	I	PRON	PRP	Case=Nom|Number=Sing|Person=1|PronType=Prs	_	_	_	_
36	kappa	kappa	PROPN	NNP	Number=Sing	_	_	_	_
37	B	b	PROPN	NNP	Number=Sing	_	_	_	_
38	alpha	alpha	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
39	,	,	PUNCT	,	_	_	_	_	_
40	which	which	PRON	WDT	PronType=Rel	_	_	_	_
41	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
42	presumed	presume	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
43	to	to	PART	TO	_	_	_	_	_
44	be	be	AUX	VB	VerbForm=Inf	_	_	_	_
45	important	important	ADJ	JJ	Degree=Pos	_	_	_	_
46	for	for	ADP	IN	_	_	_	_	_
47	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
48	subsequent	subsequent	ADJ	JJ	Degree=Pos	_	_	_	_
49	degradation	degradation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
50	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 129
# text = We have recently reported the establishment of a lipopolysaccharide (LPS)-dependent cell-free activation system of NF-kappa B in association with the induction of I kappa B alpha phosphorylation.
1	We	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
2	have	have	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
3	recently	recently	ADV	RB	_	_	_	_	_
4	reported	report	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
5	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
6	establishment	establishment	NOUN	NN	Number=Sing	_	_	_	_
7	of	of	ADP	IN	_	_	_	_	_
8	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
9	lipopolysaccharide	lipopolysaccharide	NOUN	NN	Number=Sing	_	_	_	_
10	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
11	LPS	LPS	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
12	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
13	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
14	dependent	dependent	ADJ	JJ	Degree=Pos	_	_	_	_
15	cell	cell	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
16	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
17	free	free	ADJ	JJ	Degree=Pos	_	_	_	_
18	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
19	system	system	NOUN	NN	Number=Sing	_	_	_	_
20	of	of	ADP	IN	_	_	_	_	_
21	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
22	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
23	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_
24	B	b	NOUN	NN	Number=Sing	_	_	_	_
25	in	in	ADP	IN	_	_	_	_	_
26	association	association	NOUN	NN	Number=Sing	_	_	_	_
27	with	with	ADP	IN	_	_	_	_	_
28	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
29	induction	induction	NOUN	NN	Number=Sing	_	_	_	_
30	of	of	ADP	IN	_	_	_	_	_
31	I	I	PRON	PRP	Case=Nom|Number=Sing|Person=1|PronType=Prs	_	_	_	_
32	kappa	kappa	PROPN	NNP	Number=Sing	_	_	_	_
33	B	b	PROPN	NNP	Number=Sing	_	_	_	_
34	alpha	alpha	ADP	IN	_	_	_	_	_
35	phosphorylation	phosphorylation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
36	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 130
# text = In this study, we have identified a kinase in cell extracts from the LPS-stimulated human monocytic cell line, THP-1, that specifically binds and phosphorylates I kappa B alpha.
1	In	in	ADP	IN	_	_	_	_	_
2	this	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
3	study	study	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
4	,	,	PUNCT	,	_	_	_	_	_
5	we	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
6	have	have	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
7	identified	identify	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
8	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
9	kinase	kinase	NOUN	NN	Number=Sing	_	_	_	_
10	in	in	ADP	IN	_	_	_	_	_
11	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
12	extracts	extract	NOUN	NNS	Number=Plur	_	_	_	_
13	from	from	ADP	IN	_	_	_	_	_
14	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
15	LPS	LPS	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
16	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
17	stimulated	stimulate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
18	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
19	monocytic	monocytic	ADJ	JJ	Degree=Pos	_	_	_	_
20	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
21	line	line	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
22	,	,	PUNCT	,	_	_	_	_	_
23	THP	Thp	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
24	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
25	1	1	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
26	,	,	PUNCT	,	_	_	_	_	_
27	that	that	SCONJ	IN	_	_	_	_	_
28	specifically	specifically	ADV	RB	_	_	_	_	_
29	binds	bind	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
30	and	and	CCONJ	CC	_	_	_	_	_
31	phosphorylates	phosphorylate	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
32	I	I	PRON	PRP	Case=Nom|Number=Sing|Person=1|PronType=Prs	_	_	_	_
33	kappa	kappa	X	FW	Foreign=Yes	_	_	_	_
34	B	b	ADJ	JJ	Degree=Pos	_	_	_	_
35	alpha	alpha	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
36	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 131
# text = LPS stimulation transiently enhanced the I kappa B alpha-bound kinase activity in THP-1 cells.
1	LPS	Lps	NOUN	NN	Number=Sing	_	_	_	_
2	stimulation	stimulation	NOUN	NN	Number=Sing	_	_	_	_
3	transiently	transiently	ADV	RB	_	_	_	_	_
4	enhanced	enhance	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
5	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
6	I	I	PROPN	NNP	Number=Sing	_	_	_	_
7	kappa	kappa	PROPN	NNP	Number=Sing	_	_	_	_
8	B	b	PROPN	NNP	Number=Sing	_	_	_	_
9	alpha	alpha	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
10	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
11	bound	bound	ADJ	JJ	Degree=Pos	_	_	_	_
12	kinase	kinase	NOUN	NN	Number=Sing	_	_	_	_
13	activity	activity	NOUN	NN	Number=Sing	_	_	_	_
14	in	in	ADP	IN	_	_	_	_	_
15	THP	THP	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
16	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
17	1	1	NUM	CD	NumType=Card	_	_	_	_
18	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
19	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 132
# text = Mutational analyses of I kappa B alpha and competition experiments with the synthetic peptides identified major phosphorylation sites by the bound kinase as Ser and Thr residues in the C-terminal acidic domain of I kappa B alpha.
1	Mutational	Mutational	ADJ	JJ	Degree=Pos	_	_	_	_
2	analyses	analysis	NOUN	NNS	Number=Plur	_	_	_	_
3	of	of	ADP	IN	_	_	_	_	_
4	I	I	PRON	PRP	Case=Nom|Number=Sing|Person=1|PronType=Prs	_	_	_	_
5	kappa	kappa	X	FW	Foreign=Yes	_	_	_	_
6	B	b	ADJ	JJ	Degree=Pos	_	_	_	_
7	alpha	alpha	NOUN	NN	Number=Sing	_	_	_	_
8	and	and	CCONJ	CC	_	_	_	_	_
9	competition	competition	NOUN	NN	Number=Sing	_	_	_	_
10	experiments	experiment	NOUN	NNS	Number=Plur	_	_	_	_
11	with	with	ADP	IN	_	_	_	_	_
12	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
13	synthetic	synthetic	ADJ	JJ	Degree=Pos	_	_	_	_
14	peptides	peptide	NOUN	NNS	Number=Plur	_	_	_	_
15	identified	identify	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
16	major	major	ADJ	JJ	Degree=Pos	_	_	_	_
17	phosphorylation	phosphorylation	NOUN	NN	Number=Sing	_	_	_	_
18	sites	site	NOUN	NNS	Number=Plur	_	_	_	_
19	by	by	ADP	IN	_	_	_	_	_
20	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
21	bound	bound	ADJ	JJ	Degree=Pos	_	_	_	_
22	kinase	kinase	NOUN	NN	Number=Sing	_	_	_	_
23	as	as	ADP	IN	_	_	_	_	_
24	Ser	Ser	PROPN	NNP	Number=Sing	_	_	_	_
25	and	and	CCONJ	CC	_	_	_	_	_
26	Thr	Thr	PROPN	NNP	Number=Sing	_	_	_	_
27	residues	residue	NOUN	NNS	Number=Plur	_	_	_	_
28	in	in	ADP	IN	_	_	_	_	_
29	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
30	C-	C-	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
31	terminal	terminal	ADJ	JJ	Degree=Pos	_	_	_	_
32	acidic	acidic	ADJ	JJ	Degree=Pos	_	_	_	_
33	domain	domain	NOUN	NN	Number=Sing	_	_	_	_
34	of	of	ADP	IN	_	_	_	_	_
35	I	I	PRON	PRP	Case=Nom|Number=Sing|Person=1|PronType=Prs	_	_	_	_
36	kappa	kappa	PROPN	NNP	Number=Sing	_	_	_	_
37	B	B	PROPN	NNP	Number=Sing	_	_	_	_
38	alpha	alpha	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
39	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 133
# text = Moreover, we show that the peptide, corresponding to the C-terminal acidic domain of I kappa B alpha, blocked the LPS-induced NF-kappa B activation as well as inducible phosphorylation of endogenous I kappa B alpha in a cell-free system using THP-1 cells.
1	Moreover	moreover	ADV	RB	_	_	_	_	SpaceAfter=No
2	,	,	PUNCT	,	_	_	_	_	_
3	we	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
4	show	show	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
5	that	that	SCONJ	IN	_	_	_	_	_
6	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
7	peptide	peptide	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
8	,	,	PUNCT	,	_	_	_	_	_
9	corresponding	correspond	VERB	VBG	VerbForm=Ger	_	_	_	_
10	to	to	ADP	IN	_	_	_	_	_
11	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
12	C-	c-	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
13	terminal	terminal	ADJ	JJ	Degree=Pos	_	_	_	_
14	acidic	acidic	ADJ	JJ	Degree=Pos	_	_	_	_
15	domain	domain	NOUN	NN	Number=Sing	_	_	_	_
16	of	of	ADP	IN	_	_	_	_	_
17	I	I	PRON	PRP	Case=Nom|Number=Sing|Person=1|PronType=Prs	_	_	_	_
18	kappa	kappa	PROPN	NNP	Number=Sing	_	_	_	_
19	B	B	PROPN	NNP	Number=Sing	_	_	_	_
20	alpha	alpha	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
21	,	,	PUNCT	,	_	_	_	_	_
22	blocked	block	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
23	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
24	LPS	LPS	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
25	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
26	induced	induce	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
27	NF	Nf	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
28	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
29	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_
30	B	b	NOUN	NN	Number=Sing	_	_	_	_
31	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
32	as	as	ADV	RB	_	_	_	_	_
33	well	well	ADV	RB	Degree=Pos	_	_	_	_
34	as	as	ADP	IN	_	_	_	_	_
35	inducible	inducible	ADJ	JJ	Degree=Pos	_	_	_	_
36	phosphorylation	phosphorylation	NOUN	NN	Number=Sing	_	_	_	_
37	of	of	ADP	IN	_	_	_	_	_
38	endogenous	endogenous	ADJ	JJ	Degree=Pos	_	_	_	_
39	I	I	PRON	PRP	Case=Nom|Number=Sing|Person=1|PronType=Prs	_	_	_	_
40	kappa	kappa	PROPN	NNP	Number=Sing	_	_	_	_
41	B	b	PROPN	NNP	Number=Sing	_	_	_	_
42	alpha	alpha	NOUN	NN	Number=Sing	_	_	_	_
43	in	in	ADP	IN	_	_	_	_	_
44	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
45	cell	cell	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
46	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
47	free	free	ADJ	JJ	Degree=Pos	_	_	_	_
48	system	system	NOUN	NN	Number=Sing	_	_	_	_
49	using	using	VERB	VBG	VerbForm=Ger	_	_	_	_
50	THP	Thp	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
51	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
52	1	1	NUM	CD	NumType=Card	_	_	_	_
53	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
54	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 134
# text = These results suggested that the bound kinase is involved in the signaling pathway of LPS by inducing the phosphorylation of the C-terminal region of
1	These	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
2	results	result	NOUN	NNS	Number=Plur	_	_	_	_
3	suggested	suggest	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
4	that	that	SCONJ	IN	_	_	_	_	_
5	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
6	bound	bound	ADJ	JJ	Degree=Pos	_	_	_	_
7	kinase	kinase	NOUN	NN	Number=Sing	_	_	_	_
8	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
9	involved	involved	ADJ	JJ	Degree=Pos	_	_	_	_
10	in	in	ADP	IN	_	_	_	_	_
11	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
12	signaling	signaling	NOUN	NN	Number=Sing	_	_	_	_
13	pathway	pathway	NOUN	NN	Number=Sing	_	_	_	_
14	of	of	ADP	IN	_	_	_	_	_
15	LPS	LPS	PROPN	NNP	Number=Sing	_	_	_	_
16	by	by	SCONJ	IN	_	_	_	_	_
17	inducing	induce	VERB	VBG	VerbForm=Ger	_	_	_	_
18	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
19	phosphorylation	phosphorylation	NOUN	NN	Number=Sing	_	_	_	_
20	of	of	ADP	IN	_	_	_	_	_
21	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
22	C-	c-	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
23	terminal	terminal	NOUN	NN	Number=Sing	_	_	_	_
24	region	region	NOUN	NN	Number=Sing	_	_	_	_
25	of	of	ADP	IN	_	_	_	_	_

# sent_id = 135
# text = I kappa B alpha and subsequent dissociation of the NF-kappa B.I kappa B alpha complex.
1	I	I	PRON	PRP	Case=Nom|Number=Sing|Person=1|PronType=Prs	_	_	_	_
2	kappa	kappa	X	FW	Foreign=Yes	_	_	_	_
3	B	b	ADJ	JJ	Degree=Pos	_	_	_	_
4	alpha	alpha	NOUN	NN	Number=Sing	_	_	_	_
5	and	and	CCONJ	CC	_	_	_	_	_
6	subsequent	subsequent	ADJ	JJ	Degree=Pos	_	_	_	_
7	dissociation	dissociation	NOUN	NN	Number=Sing	_	_	_	_
8	of	of	ADP	IN	_	_	_	_	_
9	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
10	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
11	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
12	kappa	kappa	PROPN	NNP	Number=Sing	_	_	_	_
13	B.	B.	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
14	I	I	PRON	PRP	Case=Nom|Number=Sing|Person=1|PronType=Prs	_	_	_	_
15	kappa	kappa	X	FW	Foreign=Yes	_	_	_	_
16	B	b	X	LS	_	_	_	_	_
17	alpha	alpha	X	FW	Foreign=Yes	_	_	_	_
18	complex	complex	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
19	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 136
# text = Document 00300245 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	00300245	00300245	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 137
# text = MIP1 alpha nuclear protein (MNP), a novel transcription factor expressed in hematopoietic cells that is crucial for transcription of the human MIP-1 alpha gene.
1	MIP1	MIP1	X	LS	_	_	_	_	_
2	alpha	alpha	X	FW	Foreign=Yes	_	_	_	_
3	nuclear	nuclear	ADJ	JJ	Degree=Pos	_	_	_	_
4	protein	protein	NOUN	NN	Number=Sing	_	_	_	_
5	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
6	MNP	MNP	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
7	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
8	,	,	PUNCT	,	_	_	_	_	_
9	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
10	novel	novel	NOUN	NN	Number=Sing	_	_	_	_
11	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
12	factor	factor	NOUN	NN	Number=Sing	_	_	_	_
13	expressed	express	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
14	in	in	ADP	IN	_	_	_	_	_
15	hematopoietic	hematopoietic	ADJ	JJ	Degree=Pos	_	_	_	_
16	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
17	that	that	PRON	WDT	PronType=Rel	_	_	_	_
18	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
19	crucial	crucial	ADJ	JJ	Degree=Pos	_	_	_	_
20	for	for	ADP	IN	_	_	_	_	_
21	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
22	of	of	ADP	IN	_	_	_	_	_
23	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
24	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
25	MIP	Mip	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
26	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
27	1	1	NUM	CD	NumType=Card	_	_	_	_
28	alpha	alpha	NOUN	NN	Number=Sing	_	_	_	_
29	gene	gene	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
30	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 138
# text = Murine macrophage inflammatory protein 1 alpha (MIP-1 alpha) and its human equivalent (GOS19, LD78, or AT464) are members of the -C-C family of low-molecular-weight chemokines.
1	Murine	Murine	PRON	PRP	_	_	_	_	_
2	macrophage	macrophage	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
3	inflammatory	inflammatory	ADJ	JJ	Degree=Pos	_	_	_	_
4	protein	protein	NOUN	NN	Number=Sing	_	_	_	_
5	1	1	NUM	CD	NumType=Card	_	_	_	_
6	alpha	alpha	NOUN	NN	Number=Sing	_	_	_	_
7	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
8	MIP	Mip	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
9	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
10	1	1	NUM	CD	NumType=Card	_	_	_	_
11	alpha	alpha	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
12	)	)	PUNCT	-RRB-	_	_	_	_	_
13	and	and	CCONJ	CC	_	_	_	_	_
14	its	its	PRON	PRP$	Gender=Neut|Number=Sing|Person=3|Poss=Yes|PronType=Prs	_	_	_	_
15	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
16	equivalent	equivalent	NOUN	NN	Number=Sing	_	_	_	_
17	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
18	GOS19	GOS19	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
19	,	,	PUNCT	,	_	_	_	_	_
20	LD78	LD78	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
21	,	,	PUNCT	,	_	_	_	_	_
22	or	or	CCONJ	CC	_	_	_	_	_
23	AT464	At464	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
24	)	)	PUNCT	-RRB-	_	_	_	_	_
25	are	be	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
26	members	member	NOUN	NNS	Number=Plur	_	_	_	_
27	of	of	ADP	IN	_	_	_	_	_
28	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
29	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
30	C	C	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
31	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
32	C	C	PROPN	NNP	Number=Sing	_	_	_	_
33	family	family	NOUN	NN	Number=Sing	_	_	_	_
34	of	of	ADP	IN	_	_	_	_	_
35	low-	low-	SYM	NFP	_	_	_	_	SpaceAfter=No
36	molecular	molecular	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
37	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
38	weight	weight	NOUN	NN	Number=Sing	_	_	_	_
39	chemokines	chemokine	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
40	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 139
# text = Secreted from activated T cells and macrophages, bone marrow-derived MIP-1 alpha/GOS19 inhibits primitive hematopoietic stem cells and appears to be involved in the homeostatic control of stem cell proliferation.
1	Secreted	Secret	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
2	from	from	ADP	IN	_	_	_	_	_
3	activated	activate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
4	T	t	PROPN	NNP	Number=Sing	_	_	_	_
5	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
6	and	and	CCONJ	CC	_	_	_	_	_
7	macrophages	macrophage	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
8	,	,	PUNCT	,	_	_	_	_	_
9	bone	bone	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
10	marrow	marrow	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
11	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
12	derived	derive	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
13	MIP	Mip	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
14	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
15	1	1	NUM	CD	NumType=Card	_	_	_	_
16	alpha	alpha	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
17	/	/	PUNCT	,	_	_	_	_	SpaceAfter=No
18	GOS19	GOS19	NUM	CD	NumType=Card	_	_	_	_
19	inhibits	inhibit	NOUN	NNS	Number=Plur	_	_	_	_
20	primitive	primitive	ADJ	JJ	Degree=Pos	_	_	_	_
21	hematopoietic	hematopoietic	ADJ	JJ	Degree=Pos	_	_	_	_
22	stem	stem	NOUN	NN	Number=Sing	_	_	_	_
23	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
24	and	and	CCONJ	CC	_	_	_	_	_
25	appears	appear	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
26	to	to	PART	TO	_	_	_	_	_
27	be	be	AUX	VB	VerbForm=Inf	_	_	_	_
28	involved	involved	ADJ	JJ	Degree=Pos	_	_	_	_
29	in	in	ADP	IN	_	_	_	_	_
30	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
31	homeostatic	homeostatic	ADJ	JJ	Degree=Pos	_	_	_	_
32	control	control	NOUN	NN	Number=Sing	_	_	_	_
33	of	of	ADP	IN	_	_	_	_	_
34	stem	stem	NOUN	NN	Number=Sing	_	_	_	_
35	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
36	proliferation	proliferation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
37	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 140
# text = It also induces chemotaxis and inflammatory responses in mature cell types.
1	It	it	PRON	PRP	Case=Nom|Gender=Neut|Number=Sing|Person=3|PronType=Prs	_	_	_	_
2	also	also	ADV	RB	_	_	_	_	_
3	induces	induce	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
4	chemotaxis	chemotaxis	NOUN	NN	Number=Sing	_	_	_	_
5	and	and	CCONJ	CC	_	_	_	_	_
6	inflammatory	inflammatory	ADJ	JJ	Degree=Pos	_	_	_	_
7	responses	response	NOUN	NNS	Number=Plur	_	_	_	_
8	in	in	ADP	IN	_	_	_	_	_
9	mature	mature	ADJ	JJ	Degree=Pos	_	_	_	_
10	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
11	types	type	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
12	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 141
# text = Therefore, it is important to understand the mechanisms which control the expression of MIP-1 alpha/GOS19.
1	Therefore	therefore	ADV	RB	_	_	_	_	SpaceAfter=No
2	,	,	PUNCT	,	_	_	_	_	_
3	it	it	PRON	PRP	Case=Nom|Gender=Neut|Number=Sing|Person=3|PronType=Prs	_	_	_	_
4	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
5	important	important	ADJ	JJ	Degree=Pos	_	_	_	_
6	to	to	PART	TO	_	_	_	_	_
7	understand	understand	VERB	VB	VerbForm=Inf	_	_	_	_
8	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
9	mechanisms	mechanism	NOUN	NNS	Number=Plur	_	_	_	_
10	which	which	PRON	WDT	PronType=Rel	_	_	_	_
11	control	control	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
12	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
13	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
14	of	of	ADP	IN	_	_	_	_	_
15	MIP	MIP	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
16	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
17	1	1	NUM	CD	NumType=Card	_	_	_	_
18	alpha/	alpha/	SYM	SYM	_	_	_	_	SpaceAfter=No
19	GOS19	GOS19	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
20	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 142
# text = Previous work has shown that in Jurkat T cells, a set of widely expressed transcription factors (the ICK-1 family) affect the GOS19 promoter.
1	Previous	previous	ADJ	JJ	Degree=Pos	_	_	_	_
2	work	work	NOUN	NN	Number=Sing	_	_	_	_
3	has	have	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
4	shown	show	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
5	that	that	SCONJ	IN	_	_	_	_	_
6	in	in	ADP	IN	_	_	_	_	_
7	Jurkat	Jurkat	PROPN	NNP	Number=Sing	_	_	_	_
8	T	T	PROPN	NNP	Number=Sing	_	_	_	_
9	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
10	,	,	PUNCT	,	_	_	_	_	_
11	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
12	set	set	NOUN	NN	Number=Sing	_	_	_	_
13	of	of	ADP	IN	_	_	_	_	_
14	widely	widely	ADV	RB	_	_	_	_	_
15	expressed	express	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
16	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
17	factors	factor	NOUN	NNS	Number=Plur	_	_	_	_
18	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
19	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
20	ICK	ICK	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
21	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
22	1	1	NUM	CD	NumType=Card	_	_	_	_
23	family	family	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
24	)	)	PUNCT	-RRB-	_	_	_	_	_
25	affect	affect	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
26	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
27	GOS19	GOS19	NUM	CD	NumType=Card	_	_	_	_
28	promoter	promoter	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
29	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 143
# text = One member, ICK-1A, behaves as a strong negative regulator.
1	One	one	NUM	CD	NumType=Card	_	_	_	_
2	member	member	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
3	,	,	PUNCT	,	_	_	_	_	_
4	ICK	ICK	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
5	-	-	SYM	SYM	_	_	_	_	SpaceAfter=No
6	1	1	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
7	A	a	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
8	,	,	PUNCT	,	_	_	_	_	_
9	behaves	behave	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
10	as	as	ADP	IN	_	_	_	_	_
11	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
12	strong	strong	ADJ	JJ	Degree=Pos	_	_	_	_
13	negative	negative	ADJ	JJ	Degree=Pos	_	_	_	_
14	regulator	regulator	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
15	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 144
# text = In this communication, we provide evidence that the pathway of induction in the macrophage cell line U937 is different from that in Jurkat cells.
1	In	in	ADP	IN	_	_	_	_	_
2	this	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
3	communication	communication	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
4	,	,	PUNCT	,	_	_	_	_	_
5	we	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
6	provide	provide	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
7	evidence	evidence	NOUN	NN	Number=Sing	_	_	_	_
8	that	that	SCONJ	IN	_	_	_	_	_
9	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
10	pathway	pathway	NOUN	NN	Number=Sing	_	_	_	_
11	of	of	ADP	IN	_	_	_	_	_
12	induction	induction	NOUN	NN	Number=Sing	_	_	_	_
13	in	in	ADP	IN	_	_	_	_	_
14	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
15	macrophage	macrophage	NOUN	NN	Number=Sing	_	_	_	_
16	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
17	line	line	NOUN	NN	Number=Sing	_	_	_	_
18	U937	U937	NOUN	NN	Number=Sing	_	_	_	_
19	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
20	different	different	ADJ	JJ	Degree=Pos	_	_	_	_
21	from	from	ADP	IN	_	_	_	_	_
22	that	that	PRON	DT	Number=Sing|PronType=Dem	_	_	_	_
23	in	in	ADP	IN	_	_	_	_	_
24	Jurkat	Jurkat	PROPN	NNP	Number=Sing	_	_	_	_
25	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
26	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 145
# text = Furthermore, we show that the ICK-1 binding site does not confer negative regulation in U937 cells.
1	Furthermore	furthermore	ADV	RB	_	_	_	_	SpaceAfter=No
2	,	,	PUNCT	,	_	_	_	_	_
3	we	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
4	show	show	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
5	that	that	SCONJ	IN	_	_	_	_	_
6	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
7	ICK	Ick	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
8	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
9	1	1	NUM	CD	NumType=Card	_	_	_	_
10	binding	binding	NOUN	NN	Number=Sing	_	_	_	_
11	site	site	NOUN	NN	Number=Sing	_	_	_	_
12	does	do	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
13	not	not	PART	RB	_	_	_	_	_
14	confer	confer	VERB	VB	VerbForm=Inf	_	_	_	_
15	negative	negative	ADJ	JJ	Degree=Pos	_	_	_	_
16	regulation	regulation	NOUN	NN	Number=Sing	_	_	_	_
17	in	in	ADP	IN	_	_	_	_	_
18	U937	U937	NUM	CD	NumType=Card	_	_	_	_
19	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
20	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 146
# text = We provide evidence for an additional binding site, the MIP-1 alpha nuclear protein (MNP) site, which overlaps the ICK-1 site.
1	We	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
2	provide	provide	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
3	evidence	evidence	NOUN	NN	Number=Sing	_	_	_	_
4	for	for	ADP	IN	_	_	_	_	_
5	an	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
6	additional	additional	ADJ	JJ	Degree=Pos	_	_	_	_
7	binding	binding	NOUN	NN	Number=Sing	_	_	_	_
8	site	site	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
9	,	,	PUNCT	,	_	_	_	_	_
10	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
11	MIP	Mip	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
12	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
13	1	1	NUM	CD	NumType=Card	_	_	_	_
14	alpha	alpha	NOUN	NN	Number=Sing	_	_	_	_
15	nuclear	nuclear	ADJ	JJ	Degree=Pos	_	_	_	_
16	protein	protein	NOUN	NN	Number=Sing	_	_	_	_
17	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
18	MNP	MNP	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
19	)	)	PUNCT	-RRB-	_	_	_	_	_
20	site	site	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
21	,	,	PUNCT	,	_	_	_	_	_
22	which	which	PRON	WDT	PronType=Rel	_	_	_	_
23	overlaps	overlaps	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
24	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
25	ICK	ick	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
26	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
27	1	1	NUM	CD	NumType=Card	_	_	_	_
28	site	site	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
29	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 147
# text = Interaction of nuclear extracts from various cell lines and tissue with the MNP site leads to the formation of fast-migrating protein-DNA complexes with similar but distinct electrophoretic mobilities.
1	Interaction	interaction	NOUN	NN	Number=Sing	_	_	_	_
2	of	of	ADP	IN	_	_	_	_	_
3	nuclear	nuclear	ADJ	JJ	Degree=Pos	_	_	_	_
4	extracts	extract	NOUN	NNS	Number=Plur	_	_	_	_
5	from	from	ADP	IN	_	_	_	_	_
6	various	various	ADJ	JJ	Degree=Pos	_	_	_	_
7	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
8	lines	line	NOUN	NNS	Number=Plur	_	_	_	_
9	and	and	CCONJ	CC	_	_	_	_	_
10	tissue	tissue	NOUN	NN	Number=Sing	_	_	_	_
11	with	with	ADP	IN	_	_	_	_	_
12	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
13	MNP	MNP	PROPN	NNP	Number=Sing	_	_	_	_
14	site	site	NOUN	NN	Number=Sing	_	_	_	_
15	leads	lead	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
16	to	to	ADP	IN	_	_	_	_	_
17	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
18	formation	formation	NOUN	NN	Number=Sing	_	_	_	_
19	of	of	ADP	IN	_	_	_	_	_
20	fast	fast	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
21	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
22	migrating	migrating	NOUN	NN	Number=Sing	_	_	_	_
23	protein	protein	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
24	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
25	DNA	dna	NOUN	NN	Number=Sing	_	_	_	_
26	complexes	complex	NOUN	NNS	Number=Plur	_	_	_	_
27	with	with	ADP	IN	_	_	_	_	_
28	similar	similar	ADJ	JJ	Degree=Pos	_	_	_	_
29	but	but	CCONJ	CC	_	_	_	_	_
30	distinct	distinct	ADJ	JJ	Degree=Pos	_	_	_	_
31	electrophoretic	electrophoretic	ADJ	JJ	Degree=Pos	_	_	_	_
32	mobilities	mobility	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
33	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 148
# text = A mutation of the MNP site which does not abrogate ICK-1 binding inactivates the GOS19.1 promoter in U937 cells and reduces its activity by fourfold in Jurkat cells.
1	A	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
2	mutation	mutation	NOUN	NN	Number=Sing	_	_	_	_
3	of	of	ADP	IN	_	_	_	_	_
4	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
5	MNP	MNP	PROPN	NNP	Number=Sing	_	_	_	_
6	site	site	NOUN	NN	Number=Sing	_	_	_	_
7	which	which	PRON	WDT	PronType=Rel	_	_	_	_
8	does	do	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
9	not	not	PART	RB	_	_	_	_	_
10	abrogate	abrogate	VERB	VB	VerbForm=Inf	_	_	_	_
11	ICK	Ick	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
12	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
13	1	1	NUM	CD	NumType=Card	_	_	_	_
14	binding	binding	NOUN	NN	Number=Sing	_	_	_	_
15	inactivates	inactivate	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
16	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
17	GOS19.1	Gos19.1	PROPN	NNP	Number=Sing	_	_	_	_
18	promoter	promoter	NOUN	NN	Number=Sing	_	_	_	_
19	in	in	ADP	IN	_	_	_	_	_
20	U937	U937	NUM	CD	NumType=Card	_	_	_	_
21	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
22	and	and	CCONJ	CC	_	_	_	_	_
23	reduces	reduce	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
24	its	its	PRON	PRP$	Gender=Neut|Number=Sing|Person=3|Poss=Yes|PronType=Prs	_	_	_	_
25	activity	activity	NOUN	NN	Number=Sing	_	_	_	_
26	by	by	ADP	IN	_	_	_	_	_
27	fourfold	fourfold	NOUN	NN	Number=Sing	_	_	_	_
28	in	in	ADP	IN	_	_	_	_	_
29	Jurkat	Jurkat	PROPN	NNP	Number=Sing	_	_	_	_
30	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
31	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 149
# text = We propose that the MNP protein(s) binding at the MNP site constitutes a novel transcription factor(s) expressed in hematopoietic cells.
1	We	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
2	propose	propose	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
3	that	that	SCONJ	IN	_	_	_	_	_
4	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
5	MNP	Mnp	NOUN	NN	Number=Sing	_	_	_	_
6	protein	protein	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
7	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
8	s	s	X	AFX	_	_	_	_	SpaceAfter=No
9	)	)	PUNCT	-RRB-	_	_	_	_	_
10	binding	bind	VERB	VBG	VerbForm=Ger	_	_	_	_
11	at	at	ADP	IN	_	_	_	_	_
12	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
13	MNP	MNP	PROPN	NNP	Number=Sing	_	_	_	_
14	site	site	NOUN	NN	Number=Sing	_	_	_	_
15	constitutes	constitute	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
16	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
17	novel	novel	NOUN	NN	Number=Sing	_	_	_	_
18	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
19	factor	factor	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
20	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
21	s	s	X	AFX	_	_	_	_	SpaceAfter=No
22	)	)	PUNCT	-RRB-	_	_	_	_	_
23	expressed	express	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
24	in	in	ADP	IN	_	_	_	_	_
25	hematopoietic	hematopoietic	ADJ	JJ	Degree=Pos	_	_	_	_
26	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
27	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 150
# text = Document 00300247 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	00300247	00300247	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 151
# text = Interferons induce normal and aberrant retinoic-acid receptors type alpha in acute promyelocytic leukemia cells: potentiation of the induction of retinoid-dependent differentiation markers.
1	Interferons	Interferon	NOUN	NNS	Number=Plur	_	_	_	_
2	induce	induce	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
3	normal	normal	ADJ	JJ	Degree=Pos	_	_	_	_
4	and	and	CCONJ	CC	_	_	_	_	_
5	aberrant	aberrant	ADJ	JJ	Degree=Pos	_	_	_	_
6	retinoic	retinoic	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
7	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
8	acid	acid	ADJ	JJ	Degree=Pos	_	_	_	_
9	receptors	receptor	NOUN	NN	Number=Sing	_	_	_	_
10	type	type	NOUN	NN	Number=Sing	_	_	_	_
11	alpha	alpha	NOUN	NN	Number=Sing	_	_	_	_
12	in	in	ADP	IN	_	_	_	_	_
13	acute	acute	ADJ	JJ	Degree=Pos	_	_	_	_
14	promyelocytic	promyelocytic	ADJ	JJ	Degree=Pos	_	_	_	_
15	leukemia	leukemia	NOUN	NN	Number=Sing	_	_	_	_
16	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
17	:	:	PUNCT	:	_	_	_	_	_
18	potentiation	potentiation	NOUN	NN	Number=Sing	_	_	_	_
19	of	of	ADP	IN	_	_	_	_	_
20	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
21	induction	induction	NOUN	NN	Number=Sing	_	_	_	_
22	of	of	ADP	IN	_	_	_	_	_
23	retinoid	retinoid	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
24	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
25	dependent	dependent	ADJ	JJ	Degree=Pos	_	_	_	_
26	differentiation	differentiation	NOUN	NN	Number=Sing	_	_	_	_
27	markers	marker	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
28	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 152
# text = Treatment of the acute promyelocytic (APL) cell line NB4 with interferon alpha (IFN(alpha)), as well as IFN(beta) and gamma, results in an increased expression of the transcripts coding for retinoic-acid receptor type alpha (RAR(alpha)) and the leukemia-specific retinoic acid receptor PML-RAR.
1	Treatment	treatment	NOUN	NN	Number=Sing	_	_	_	_
2	of	of	ADP	IN	_	_	_	_	_
3	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
4	acute	acute	ADJ	JJ	Degree=Pos	_	_	_	_
5	promyelocytic	promyelocytic	NOUN	NN	Number=Sing	_	_	_	_
6	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
7	APL	APL	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
8	)	)	PUNCT	-RRB-	_	_	_	_	_
9	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
10	line	line	NOUN	NN	Number=Sing	_	_	_	_
11	NB4	Nb4	NOUN	NN	Number=Sing	_	_	_	_
12	with	with	ADP	IN	_	_	_	_	_
13	interferon	interferon	NOUN	NN	Number=Sing	_	_	_	_
14	alpha	alpha	NOUN	NN	Number=Sing	_	_	_	_
15	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
16	IFN	Ifn	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
17	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
18	alpha	alpha	X	FW	Foreign=Yes	_	_	_	SpaceAfter=No
19	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
20	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
21	,	,	PUNCT	,	_	_	_	_	_
22	as	as	ADV	RB	_	_	_	_	_
23	well	well	ADV	RB	Degree=Pos	_	_	_	_
24	as	as	ADP	IN	_	_	_	_	_
25	IFN	IFN	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
26	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
27	beta	beta	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
28	)	)	PUNCT	-RRB-	_	_	_	_	_
29	and	and	CCONJ	CC	_	_	_	_	_
30	gamma	gamma	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
31	,	,	PUNCT	,	_	_	_	_	_
32	results	result	NOUN	NNS	Number=Plur	_	_	_	_
33	in	in	ADP	IN	_	_	_	_	_
34	an	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
35	increased	increase	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
36	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
37	of	of	ADP	IN	_	_	_	_	_
38	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
39	transcripts	transcript	NOUN	NNS	Number=Plur	_	_	_	_
40	coding	cod	VERB	VBG	VerbForm=Ger	_	_	_	_
41	for	for	ADP	IN	_	_	_	_	_
42	retinoic	retinoic	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
43	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
44	acid	acid	ADJ	JJ	Degree=Pos	_	_	_	_
45	receptor	receptor	NOUN	NN	Number=Sing	_	_	_	_
46	type	type	NOUN	NN	Number=Sing	_	_	_	_
47	alpha	alpha	NOUN	NN	Number=Sing	_	_	_	_
48	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
49	RAR	Rar	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
50	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
51	alpha	alpha	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
52	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
53	)	)	PUNCT	-RRB-	_	_	_	_	_
54	and	and	CCONJ	CC	_	_	_	_	_
55	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
56	leukemia	leukemia	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
57	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
58	specific	specific	ADJ	JJ	Degree=Pos	_	_	_	_
59	retinoic	retinoic	ADJ	JJ	Degree=Pos	_	_	_	_
60	acid	acid	NOUN	NN	Number=Sing	_	_	_	_
61	receptor	receptor	NOUN	NN	Number=Sing	_	_	_	_
62	PML	PML	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
63	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
64	RAR	RAR	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
65	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 153
# text = Transcriptional induction of the RAR(alpha) and PML-RAR mRNAs is rapid and it is parallelled by an increase in the corresponding proteins.
1	Transcriptional	Transcriptional	ADJ	JJ	Degree=Pos	_	_	_	_
2	induction	induction	NOUN	NN	Number=Sing	_	_	_	_
3	of	of	ADP	IN	_	_	_	_	_
4	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
5	RAR	RAR	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
6	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
7	alpha	alpha	X	FW	Foreign=Yes	_	_	_	SpaceAfter=No
8	)	)	PUNCT	-RRB-	_	_	_	_	_
9	and	and	CCONJ	CC	_	_	_	_	_
10	PML	PML	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
11	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
12	RAR	RAR	PROPN	NNP	Number=Sing	_	_	_	_
13	mRNAs	mRNAs	PROPN	NNP	Number=Sing	_	_	_	_
14	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
15	rapid	rapid	ADJ	JJ	Degree=Pos	_	_	_	_
16	and	and	CCONJ	CC	_	_	_	_	_
17	it	it	PRON	PRP	Case=Nom|Gender=Neut|Number=Sing|Person=3|PronType=Prs	_	_	_	_
18	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
19	parallelled	parallell	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
20	by	by	ADP	IN	_	_	_	_	_
21	an	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
22	increase	increase	NOUN	NN	Number=Sing	_	_	_	_
23	in	in	ADP	IN	_	_	_	_	_
24	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
25	corresponding	corresponding	NOUN	NN	Number=Sing	_	_	_	_
26	proteins	protein	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
27	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 154
# text = Up-regulation of RAR(alpha) and PML-RAR gene expression by IFN(alpha) is accompanied by a strong potentiation in the induction of 2 retinoid-dependent granulocytic markers, i.e., granulocyte-colony-stimulating factor receptor mRNA and leukocyte alkaline phosphatase.
1	Up-	Up-	SYM	NFP	_	_	_	_	SpaceAfter=No
2	regulation	regulation	NOUN	NN	Number=Sing	_	_	_	_
3	of	of	ADP	IN	_	_	_	_	_
4	RAR	RAR	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
5	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
6	alpha	alpha	X	FW	Foreign=Yes	_	_	_	SpaceAfter=No
7	)	)	PUNCT	-RRB-	_	_	_	_	_
8	and	and	CCONJ	CC	_	_	_	_	_
9	PML	PML	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
10	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
11	RAR	RAR	PROPN	NNP	Number=Sing	_	_	_	_
12	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
13	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
14	by	by	ADP	IN	_	_	_	_	_
15	IFN	IFN	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
16	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
17	alpha	alpha	X	FW	Foreign=Yes	_	_	_	SpaceAfter=No
18	)	)	PUNCT	-RRB-	_	_	_	_	_
19	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
20	accompanied	accompany	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
21	by	by	ADP	IN	_	_	_	_	_
22	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
23	strong	strong	ADJ	JJ	Degree=Pos	_	_	_	_
24	potentiation	potentiation	NOUN	NN	Number=Sing	_	_	_	_
25	in	in	ADP	IN	_	_	_	_	_
26	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
27	induction	induction	NOUN	NN	Number=Sing	_	_	_	_
28	of	of	ADP	IN	_	_	_	_	_
29	2	2	NUM	CD	NumType=Card	_	_	_	_
30	retinoid	retinoid	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	SpaceAfter=No
31	-dependent	-dependent	ADJ	JJ	Degree=Pos	_	_	_	_
32	granulocytic	granulocytic	ADJ	JJ	Degree=Pos	_	_	_	_
33	markers	marker	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
34	,	,	PUNCT	,	_	_	_	_	_
35	i.e.	i.e.	X	FW	_	_	_	_	SpaceAfter=No
36	,	,	PUNCT	,	_	_	_	_	_
37	granulocyte	granulocyte	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
38	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
39	colony	colony	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
40	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
41	stimulating	stimulate	VERB	VBG	VerbForm=Ger	_	_	_	_
42	factor	factor	NOUN	NN	Number=Sing	_	_	_	_
43	receptor	receptor	NOUN	NN	Number=Sing	_	_	_	_
44	mRNA	mRNa	NOUN	NN	Number=Sing	_	_	_	_
45	and	and	CCONJ	CC	_	_	_	_	_
46	leukocyte	leukocyte	NOUN	NN	Number=Sing	_	_	_	_
47	alkaline	alkaline	NOUN	NN	Number=Sing	_	_	_	_
48	phosphatase	phosphatase	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
49	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 155
# text = However, IFN(alpha) does not have any effects on the retinoid-dependent regulation of the myeloid surface markers CD11b and CD33.
1	However	however	ADV	RB	_	_	_	_	SpaceAfter=No
2	,	,	PUNCT	,	_	_	_	_	_
3	IFN(	IFN(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
4	alpha	alpha	X	FW	Foreign=Yes	_	_	_	SpaceAfter=No
5	)	)	PUNCT	-RRB-	_	_	_	_	_
6	does	do	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
7	not	not	PART	RB	_	_	_	_	_
8	have	have	VERB	VB	VerbForm=Inf	_	_	_	_
9	any	any	DET	DT	_	_	_	_	_
10	effects	effect	NOUN	NNS	Number=Plur	_	_	_	_
11	on	on	ADP	IN	_	_	_	_	_
12	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
13	retinoid	retinoid	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
14	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
15	dependent	dependent	ADJ	JJ	Degree=Pos	_	_	_	_
16	regulation	regulation	NOUN	NN	Number=Sing	_	_	_	_
17	of	of	ADP	IN	_	_	_	_	_
18	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
19	myeloid	myeloid	ADJ	JJ	Degree=Pos	_	_	_	_
20	surface	surface	NOUN	NN	Number=Sing	_	_	_	_
21	markers	marker	NOUN	NNS	Number=Plur	_	_	_	_
22	CD	cd	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
23	11	11	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
24	b	b	NOUN	NN	Number=Sing	_	_	_	_
25	and	and	CCONJ	CC	_	_	_	_	_
26	CD33	CD33	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
27	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 156
# text = The IFN-dependent increase in RAR(alpha) levels and the enhancing effect of the cytokine on retinoid-dependent granulocytic markers expression may be a characteristic of PML-RAR positive cells, since the phenomena are not observed in HL-60 promyelocytes.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	IFN	Ifn	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
3	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
4	dependent	dependent	ADJ	JJ	Degree=Pos	_	_	_	_
5	increase	increase	NOUN	NN	Number=Sing	_	_	_	_
6	in	in	ADP	IN	_	_	_	_	_
7	RAR	RAR	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
8	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
9	alpha	alpha	X	FW	Foreign=Yes	_	_	_	SpaceAfter=No
10	)	)	PUNCT	-RRB-	_	_	_	_	_
11	levels	level	NOUN	NNS	Number=Plur	_	_	_	_
12	and	and	CCONJ	CC	_	_	_	_	_
13	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
14	enhancing	enhance	VERB	VBG	VerbForm=Ger	_	_	_	_
15	effect	effect	NOUN	NN	Number=Sing	_	_	_	_
16	of	of	ADP	IN	_	_	_	_	_
17	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
18	cytokine	cytokine	NOUN	NN	Number=Sing	_	_	_	_
19	on	on	ADP	IN	_	_	_	_	_
20	retinoid	retinoid	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
21	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
22	dependent	dependent	ADJ	JJ	Degree=Pos	_	_	_	_
23	granulocytic	granulocytic	ADJ	JJ	Degree=Pos	_	_	_	_
24	markers	marker	NOUN	NNS	Number=Plur	_	_	_	_
25	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
26	may	may	AUX	MD	VerbForm=Fin	_	_	_	_
27	be	be	AUX	VB	VerbForm=Inf	_	_	_	_
28	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
29	characteristic	characteristic	NOUN	NN	Number=Sing	_	_	_	_
30	of	of	ADP	IN	_	_	_	_	_
31	PML	PML	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
32	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
33	RAR	RAR	PROPN	NNP	Number=Sing	_	_	_	_
34	positive	positive	ADJ	JJ	Degree=Pos	_	_	_	_
35	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
36	,	,	PUNCT	,	_	_	_	_	_
37	since	since	SCONJ	IN	_	_	_	_	_
38	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
39	phenomena	phenomena	NOUN	NN	Number=Sing	_	_	_	_
40	are	be	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
41	not	not	PART	RB	_	_	_	_	_
42	observed	observe	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
43	in	in	ADP	IN	_	_	_	_	_
44	HL	HL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
45	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
46	60	60	NUM	CD	NumType=Card	_	_	_	_
47	promyelocytes	promyelocyte	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
48	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 157
# text = Interferons as well as retinoids inhibit the growth of NB4 cells, although the 2 classes of compounds do not significantly interact in terms of anti-proliferative activity.
1	Interferons	Interferon	NOUN	NNS	Number=Plur	_	_	_	_
2	as	as	ADV	RB	_	_	_	_	_
3	well	well	ADV	RB	Degree=Pos	_	_	_	_
4	as	as	ADP	IN	_	_	_	_	_
5	retinoids	retinoid	NOUN	NNS	Number=Plur	_	_	_	_
6	inhibit	inhibit	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
7	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
8	growth	growth	NOUN	NN	Number=Sing	_	_	_	_
9	of	of	ADP	IN	_	_	_	_	_
10	NB4	NB4	NUM	CD	NumType=Card	_	_	_	_
11	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
12	,	,	PUNCT	,	_	_	_	_	_
13	although	although	SCONJ	IN	_	_	_	_	_
14	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
15	2	2	NUM	CD	NumType=Card	_	_	_	_
16	classes	class	NOUN	NNS	Number=Plur	_	_	_	_
17	of	of	ADP	IN	_	_	_	_	_
18	compounds	compound	NOUN	NNS	Number=Plur	_	_	_	_
19	do	do	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
20	not	not	PART	RB	_	_	_	_	_
21	significantly	significantly	ADV	RB	_	_	_	_	_
22	interact	interact	VERB	VB	VerbForm=Inf	_	_	_	_
23	in	in	ADP	IN	_	_	_	_	_
24	terms	term	NOUN	NNS	Number=Plur	_	_	_	_
25	of	of	ADP	IN	_	_	_	_	_
26	anti-proliferative	anti-proliferative	ADJ	JJ	Degree=Pos	_	_	_	_
27	activity	activity	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
28	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 158
# text = These results suggest the possible use of combinations between IFNs and retinoic acid in the cyto-differentiating treatment of APL patients.
1	These	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
2	results	result	NOUN	NNS	Number=Plur	_	_	_	_
3	suggest	suggest	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
4	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
5	possible	possible	ADJ	JJ	Degree=Pos	_	_	_	_
6	use	use	NOUN	NN	Number=Sing	_	_	_	_
7	of	of	ADP	IN	_	_	_	_	_
8	combinations	combination	NOUN	NNS	Number=Plur	_	_	_	_
9	between	between	ADP	IN	_	_	_	_	_
10	IFNs	IFN	PROPN	NNPS	Number=Plur	_	_	_	_
11	and	and	CCONJ	CC	_	_	_	_	_
12	retinoic	retinoic	ADJ	JJ	Degree=Pos	_	_	_	_
13	acid	acid	NOUN	NN	Number=Sing	_	_	_	_
14	in	in	ADP	IN	_	_	_	_	_
15	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
16	cyto-differentiating	cyto-differentiating	ADJ	JJ	Degree=Pos	_	_	_	_
17	treatment	treatment	NOUN	NN	Number=Sing	_	_	_	_
18	of	of	ADP	IN	_	_	_	_	_
19	APL	Apl	ADJ	JJ	Degree=Pos	_	_	_	_
20	patients	patient	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
21	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 159
# text = Document 00300248 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	00300248	00300248	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 160
# text = Nuclear factor kappa B activates proenkephalin transcription in T lymphocytes.
1	Nuclear	nuclear	ADJ	JJ	Degree=Pos	_	_	_	_
2	factor	factor	NOUN	NN	Number=Sing	_	_	_	_
3	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_
4	B	b	NOUN	NN	Number=Sing	_	_	_	_
5	activates	activate	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
6	proenkephalin	proenkephalin	ADJ	JJ	Degree=Pos	_	_	_	_
7	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
8	in	in	ADP	IN	_	_	_	_	_
9	T	t	PROPN	NNP	Number=Sing	_	_	_	_
10	lymphocytes	lymphocyte	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
11	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 161
# text = Upon activation, T lymphocytes accumulate high levels of the neuropeptide enkephalin which correlate with high levels of proenkephalin mRNA in the cells.
1	Upon	upon	ADP	IN	_	_	_	_	_
2	activation	activation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
3	,	,	PUNCT	,	_	_	_	_	_
4	T	t	PROPN	NNP	Number=Sing	_	_	_	_
5	lymphocytes	lymphocyte	NOUN	NNS	Number=Plur	_	_	_	_
6	accumulate	accumulate	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
7	high	high	ADJ	JJ	Degree=Pos	_	_	_	_
8	levels	level	NOUN	NNS	Number=Plur	_	_	_	_
9	of	of	ADP	IN	_	_	_	_	_
10	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
11	neuropeptide	neuropeptide	ADJ	JJ	Degree=Pos	_	_	_	_
12	enkephalin	enkephalin	NOUN	NN	Number=Sing	_	_	_	_
13	which	which	PRON	WDT	PronType=Rel	_	_	_	_
14	correlate	correlate	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
15	with	with	ADP	IN	_	_	_	_	_
16	high	high	ADJ	JJ	Degree=Pos	_	_	_	_
17	levels	level	NOUN	NNS	Number=Plur	_	_	_	_
18	of	of	ADP	IN	_	_	_	_	_
19	proenkephalin	proenkephalin	ADJ	JJ	Degree=Pos	_	_	_	_
20	mRNA	mRNA	NOUN	NN	Number=Sing	_	_	_	_
21	in	in	ADP	IN	_	_	_	_	_
22	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
23	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
24	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 162
# text = Here we investigated the transcriptional basis for these changes.
1	Here	here	ADV	RB	PronType=Dem	_	_	_	_
2	we	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
3	investigated	investigate	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
4	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
5	transcriptional	transcriptional	ADJ	JJ	Degree=Pos	_	_	_	_
6	basis	basis	NOUN	NN	Number=Sing	_	_	_	_
7	for	for	ADP	IN	_	_	_	_	_
8	these	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
9	changes	change	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
10	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 163
# text = The proenkephalin promoter contains a sequence GGGGACGTCCCC, named B2, which is similar to the kappa B sequence GGGGACTTTCC, the binding site of the transcription factor nuclear factor (NF)-kappa B.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	proenkephalin	proenkephalin	ADJ	JJ	Degree=Pos	_	_	_	_
3	promoter	promoter	NOUN	NN	Number=Sing	_	_	_	_
4	contains	contain	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
5	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
6	sequence	sequence	NOUN	NN	Number=Sing	_	_	_	_
7	GGGGACGTCCCC	Ggggacgtcccc	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
8	,	,	PUNCT	,	_	_	_	_	_
9	named	nam	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
10	B2	b2	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
11	,	,	PUNCT	,	_	_	_	_	_
12	which	which	PRON	WDT	PronType=Rel	_	_	_	_
13	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
14	similar	similar	ADJ	JJ	Degree=Pos	_	_	_	_
15	to	to	ADP	IN	_	_	_	_	_
16	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
17	kappa	kappa	PROPN	NNP	Number=Sing	_	_	_	_
18	B	b	PROPN	NNP	Number=Sing	_	_	_	_
19	sequence	sequence	NOUN	NN	Number=Sing	_	_	_	_
20	GGGGACTTTCC	GGGGACTTTCC	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
21	,	,	PUNCT	,	_	_	_	_	_
22	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
23	binding	bind	VERB	VBG	VerbForm=Ger	_	_	_	_
24	site	site	NOUN	NN	Number=Sing	_	_	_	_
25	of	of	ADP	IN	_	_	_	_	_
26	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
27	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
28	factor	factor	NOUN	NN	Number=Sing	_	_	_	_
29	nuclear	nuclear	ADJ	JJ	Degree=Pos	_	_	_	_
30	factor	factor	NOUN	NN	Number=Sing	_	_	_	_
31	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
32	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
33	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
34	-	-	PUNCT	:	_	_	_	_	SpaceAfter=No
35	kappa	kappa	PROPN	NNP	Number=Sing	_	_	_	_
36	B.	B.	PROPN	NNP	Number=Sing	_	_	_	_

# sent_id = 164
# text = Activation of T lymphocytes induces an NF-kappa B-like binding activity to the B2 site, concomitant with activation of the proenkephalin promoter.
1	Activation	Activation	NOUN	NN	Number=Sing	_	_	_	_
2	of	of	ADP	IN	_	_	_	_	_
3	T	T	PROPN	NNP	Number=Sing	_	_	_	_
4	lymphocytes	lymphocyte	NOUN	NNS	Number=Plur	_	_	_	_
5	induces	induce	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
6	an	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
7	NF	Nf	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
8	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
9	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_
10	B	b	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
11	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
12	like	like	SCONJ	IN	_	_	_	_	_
13	binding	bind	VERB	VBG	VerbForm=Ger	_	_	_	_
14	activity	activity	NOUN	NN	Number=Sing	_	_	_	_
15	to	to	ADP	IN	_	_	_	_	_
16	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
17	B2	b2	NOUN	NN	Number=Sing	_	_	_	_
18	site	site	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
19	,	,	PUNCT	,	_	_	_	_	_
20	concomitant	concomitant	ADJ	JJ	Degree=Pos	_	_	_	_
21	with	with	ADP	IN	_	_	_	_	_
22	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
23	of	of	ADP	IN	_	_	_	_	_
24	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
25	proenkephalin	proenkephalin	ADJ	JJ	Degree=Pos	_	_	_	_
26	promoter	promoter	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
27	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 165
# text = Mutations at the B2 site abolish this transcriptional activation.
1	Mutations	Mutation	NOUN	NNS	Number=Plur	_	_	_	_
2	at	at	ADP	IN	_	_	_	_	_
3	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
4	B2	B2	NUM	CD	NumType=Card	_	_	_	_
5	site	site	NOUN	NN	Number=Sing	_	_	_	_
6	abolish	abolish	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
7	this	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
8	transcriptional	transcriptional	ADJ	JJ	Degree=Pos	_	_	_	_
9	activation	activation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
10	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 166
# text = The purified homodimer (two p50s) of the DNA-binding subunit of NF-kappa B binds the B2 site of proenkephalin relatively better than does the heterotetramer (two p65s plus two p50s) form of the factor.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	purified	purify	ADJ	JJ	Degree=Pos	_	_	_	_
3	homodimer	homodimer	NOUN	NN	Number=Sing	_	_	_	_
4	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
5	two	two	NUM	CD	NumType=Card	_	_	_	_
6	p50s	p50	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
7	)	)	PUNCT	-RRB-	_	_	_	_	_
8	of	of	ADP	IN	_	_	_	_	_
9	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
10	DNA	dna	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
11	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
12	binding	binding	VERB	VBG	VerbForm=Ger	_	_	_	_
13	subunit	subunit	NOUN	NN	Number=Sing	_	_	_	_
14	of	of	ADP	IN	_	_	_	_	_
15	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
16	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
17	kappa	kappa	PROPN	NNP	Number=Sing	_	_	_	_
18	B	B	PROPN	NNP	Number=Sing	_	_	_	_
19	binds	bind	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
20	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
21	B2	B2	NUM	CD	NumType=Card	_	_	_	_
22	site	site	NOUN	NN	Number=Sing	_	_	_	_
23	of	of	ADP	IN	_	_	_	_	_
24	proenkephalin	proenkephalin	NOUN	NN	Number=Sing	_	_	_	_
25	relatively	relatively	ADV	RB	_	_	_	_	_
26	better	better	ADJ	JJR	Degree=Cmp	_	_	_	_
27	than	than	ADP	IN	_	_	_	_	_
28	does	do	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
29	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
30	heterotetramer	heterotetramer	NOUN	NN	Number=Sing	_	_	_	_
31	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
32	two	two	NUM	CD	NumType=Card	_	_	_	_
33	p65s	p65	NOUN	NNS	Number=Plur	_	_	_	_
34	plus	plus	CCONJ	CC	_	_	_	_	_
35	two	two	NUM	CD	NumType=Card	_	_	_	_
36	p50s	p50	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
37	)	)	PUNCT	-RRB-	_	_	_	_	_
38	form	form	NOUN	NN	Number=Sing	_	_	_	_
39	of	of	ADP	IN	_	_	_	_	_
40	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
41	factor	factor	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
42	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 167
# text = Thus, it appears that the T-cell-specific activation of the proenkephalin promoter is mediated by NF-kappa B.
1	Thus	thus	ADV	RB	_	_	_	_	SpaceAfter=No
2	,	,	PUNCT	,	_	_	_	_	_
3	it	it	PRON	PRP	Case=Nom|Gender=Neut|Number=Sing|Person=3|PronType=Prs	_	_	_	_
4	appears	appear	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
5	that	that	SCONJ	IN	_	_	_	_	_
6	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
7	T-cell	T-cell	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
8	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
9	specific	specific	ADJ	JJ	Degree=Pos	_	_	_	_
10	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
11	of	of	ADP	IN	_	_	_	_	_
12	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
13	proenkephalin	proenkephalin	NOUN	NN	Number=Sing	_	_	_	_
14	promoter	promoter	NOUN	NN	Number=Sing	_	_	_	_
15	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
16	mediated	mediate	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
17	by	by	ADP	IN	_	_	_	_	_
18	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
19	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
20	kappa	kappa	PROPN	NNP	Number=Sing	_	_	_	_
21	B	b	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
22	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 168
# text = However, as NF-kappa B is ubiquitous and the transcriptional activation through the B2 site is T cell specific, yet another T-cell-specific factor which synergizes with NF-kappa B should be considered.
1	However	however	ADV	RB	_	_	_	_	SpaceAfter=No
2	,	,	PUNCT	,	_	_	_	_	_
3	as	as	ADP	IN	_	_	_	_	_
4	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
5	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
6	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_
7	B	b	NOUN	NN	Number=Sing	_	_	_	_
8	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
9	ubiquitous	ubiquitous	ADJ	JJ	Degree=Pos	_	_	_	_
10	and	and	CCONJ	CC	_	_	_	_	_
11	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
12	transcriptional	transcriptional	ADJ	JJ	Degree=Pos	_	_	_	_
13	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
14	through	through	ADP	IN	_	_	_	_	_
15	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
16	B2	b2	NOUN	NN	Number=Sing	_	_	_	_
17	site	site	NOUN	NN	Number=Sing	_	_	_	_
18	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
19	T	t	PROPN	NNP	Number=Sing	_	_	_	_
20	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
21	specific	specific	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
22	,	,	PUNCT	,	_	_	_	_	_
23	yet	yet	CCONJ	CC	_	_	_	_	_
24	another	another	DET	DT	_	_	_	_	_
25	T-	t-	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
26	cell	cell	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
27	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
28	specific	specific	ADJ	JJ	Degree=Pos	_	_	_	_
29	factor	factor	NOUN	NN	Number=Sing	_	_	_	_
30	which	which	PRON	WDT	PronType=Rel	_	_	_	_
31	synergizes	synergize	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
32	with	with	ADP	IN	_	_	_	_	_
33	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
34	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
35	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_
36	B	b	NOUN	NN	Number=Sing	_	_	_	_
37	should	should	AUX	MD	VerbForm=Fin	_	_	_	_
38	be	be	AUX	VB	VerbForm=Inf	_	_	_	_
39	considered	consider	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	SpaceAfter=No
40	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 169
# text = Document 00300253 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	00300253	00300253	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 170
# text = A hydrophobic domain of Ca2+-modulating cyclophilin ligand modulates calcium influx signaling in T lymphocytes.
1	A	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
2	hydrophobic	hydrophobic	ADJ	JJ	Degree=Pos	_	_	_	_
3	domain	domain	NOUN	NN	Number=Sing	_	_	_	_
4	of	of	ADP	IN	_	_	_	_	_
5	Ca2+-	Ca2+-	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
6	modulating	modulat	NOUN	NN	Number=Sing	_	_	_	_
7	cyclophilin	cyclophilin	NOUN	NN	Number=Sing	_	_	_	_
8	ligand	ligand	NOUN	NN	Number=Sing	_	_	_	_
9	modulates	modulate	NOUN	NNS	Number=Plur	_	_	_	_
10	calcium	calcium	NOUN	NN	Number=Sing	_	_	_	_
11	influx	influx	SYM	SYM	_	_	_	_	_
12	signaling	signale	VERB	VBG	VerbForm=Ger	_	_	_	_
13	in	in	ADP	IN	_	_	_	_	_
14	T	T	PROPN	NNP	Number=Sing	_	_	_	_
15	lymphocytes	lymphocyte	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
16	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 171
# text = Ca2+-modulating cyclophilin ligand (CAML) was originally described as a cyclophilin B-binding protein whose overexpression in T cells causes a rise in intracellular calcium, thus activating transcription factors responsible for the early immune response.
1	Ca2	Ca2	X	LS	_	_	_	_	SpaceAfter=No
2	+-modulating	+-modulat	ADJ	JJ	Degree=Pos	_	_	_	_
3	cyclophilin	cyclophilin	NOUN	NN	Number=Sing	_	_	_	_
4	ligand	ligand	NOUN	NN	Number=Sing	_	_	_	_
5	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
6	CAML	CAML	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
7	)	)	PUNCT	-RRB-	_	_	_	_	_
8	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
9	originally	originally	ADV	RB	_	_	_	_	_
10	described	describe	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
11	as	as	ADP	IN	_	_	_	_	_
12	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
13	cyclophilin	cyclophilin	NOUN	NN	Number=Sing	_	_	_	_
14	B	b	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
15	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
16	binding	bind	VERB	VBG	VerbForm=Ger	_	_	_	_
17	protein	protein	NOUN	NN	Number=Sing	_	_	_	_
18	whose	whose	PRON	WP$	Poss=Yes|PronType=Int	_	_	_	_
19	overexpression	overexpression	NOUN	NN	Number=Sing	_	_	_	_
20	in	in	ADP	IN	_	_	_	_	_
21	T	t	PROPN	NNP	Number=Sing	_	_	_	_
22	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
23	causes	cause	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
24	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
25	rise	rise	NOUN	NN	Number=Sing	_	_	_	_
26	in	in	ADP	IN	_	_	_	_	_
27	intracellular	intracellular	ADJ	JJ	Degree=Pos	_	_	_	_
28	calcium	calcium	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
29	,	,	PUNCT	,	_	_	_	_	_
30	thus	thus	ADV	RB	_	_	_	_	_
31	activating	activat	VERB	VBG	VerbForm=Ger	_	_	_	_
32	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
33	factors	factor	NOUN	NNS	Number=Plur	_	_	_	_
34	responsible	responsible	ADJ	JJ	Degree=Pos	_	_	_	_
35	for	for	ADP	IN	_	_	_	_	_
36	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
37	early	early	ADJ	JJ	Degree=Pos	_	_	_	_
38	immune	immune	ADJ	JJ	Degree=Pos	_	_	_	_
39	response	response	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
40	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 172
# text = As reported here, structure-function analysis of the CAML gene in Jurkat T cells indicates that two of CAML's putative membrane-spanning domains are necessary and sufficient for the modulation of intracellular calcium.
1	As	as	SCONJ	IN	_	_	_	_	_
2	reported	report	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
3	here	here	ADV	RB	PronType=Dem	_	_	_	SpaceAfter=No
4	,	,	PUNCT	,	_	_	_	_	_
5	structure	structure	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
6	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
7	function	function	NOUN	NN	Number=Sing	_	_	_	_
8	analysis	analysis	NOUN	NN	Number=Sing	_	_	_	_
9	of	of	ADP	IN	_	_	_	_	_
10	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
11	CAML	CAML	PROPN	NNP	Number=Sing	_	_	_	_
12	gene	gene	PROPN	NNP	Number=Sing	_	_	_	_
13	in	in	ADP	IN	_	_	_	_	_
14	Jurkat	Jurkat	PROPN	NNP	Number=Sing	_	_	_	_
15	T	T	PROPN	NNP	Number=Sing	_	_	_	_
16	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
17	indicates	indicate	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
18	that	that	SCONJ	IN	_	_	_	_	_
19	two	two	NUM	CD	NumType=Card	_	_	_	_
20	of	of	ADP	IN	_	_	_	_	_
21	CAML	CAML	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
22	's	's	PART	POS	_	_	_	_	_
23	putative	putative	ADJ	JJ	Degree=Pos	_	_	_	_
24	membrane	membrane	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
25	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
26	spanning	spanning	NOUN	NN	Number=Sing	_	_	_	_
27	domains	domain	NOUN	NNS	Number=Plur	_	_	_	_
28	are	be	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
29	necessary	necessary	ADJ	JJ	Degree=Pos	_	_	_	_
30	and	and	CCONJ	CC	_	_	_	_	_
31	sufficient	sufficient	ADJ	JJ	Degree=Pos	_	_	_	_
32	for	for	ADP	IN	_	_	_	_	_
33	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
34	modulation	modulation	NOUN	NN	Number=Sing	_	_	_	_
35	of	of	ADP	IN	_	_	_	_	_
36	intracellular	intracellular	ADJ	JJ	Degree=Pos	_	_	_	_
37	calcium	calcium	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
38	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 173
# text = We propose that the hydrophobic C-terminal tail of CAML forms its effector domain, thus implicating the N-terminal hydrophilic domain in a regulatory role.
1	We	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
2	propose	propose	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
3	that	that	SCONJ	IN	_	_	_	_	_
4	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
5	hydrophobic	hydrophobic	ADJ	JJ	Degree=Pos	_	_	_	_
6	C-	C-	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
7	terminal	terminal	NOUN	NN	Number=Sing	_	_	_	_
8	tail	tail	NOUN	NN	Number=Sing	_	_	_	_
9	of	of	ADP	IN	_	_	_	_	_
10	CAML	caml	ADJ	JJ	Degree=Pos	_	_	_	_
11	forms	form	NOUN	NNS	Number=Plur	_	_	_	_
12	its	its	PRON	PRP$	Gender=Neut|Number=Sing|Person=3|Poss=Yes|PronType=Prs	_	_	_	_
13	effector	effector	NOUN	NN	Number=Sing	_	_	_	_
14	domain	domain	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
15	,	,	PUNCT	,	_	_	_	_	_
16	thus	thus	ADV	RB	_	_	_	_	_
17	implicating	implicate	VERB	VBG	VerbForm=Ger	_	_	_	_
18	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
19	N-	n-	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
20	terminal	terminal	ADJ	JJ	Degree=Pos	_	_	_	_
21	hydrophilic	hydrophilic	ADJ	JJ	Degree=Pos	_	_	_	_
22	domain	domain	NOUN	NN	Number=Sing	_	_	_	_
23	in	in	ADP	IN	_	_	_	_	_
24	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
25	regulatory	regulatory	ADJ	JJ	Degree=Pos	_	_	_	_
26	role	role	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
27	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 174
# text = These findings define a novel protein motif that functions in intracellular calcium signaling.
1	These	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
2	findings	finding	NOUN	NNS	Number=Plur	_	_	_	_
3	define	define	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
4	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
5	novel	novel	NOUN	NN	Number=Sing	_	_	_	_
6	protein	protein	NOUN	NN	Number=Sing	_	_	_	_
7	motif	motif	SCONJ	IN	_	_	_	_	_
8	that	that	SCONJ	IN	_	_	_	_	_
9	functions	function	NOUN	NNS	Number=Plur	_	_	_	_
10	in	in	ADP	IN	_	_	_	_	_
11	intracellular	intracellular	ADJ	JJ	Degree=Pos	_	_	_	_
12	calcium	calcium	NOUN	NN	Number=Sing	_	_	_	_
13	signaling	signaling	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
14	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 175
# text = Document 00300255 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	00300255	00300255	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 176
# text = Regulation of interleukin-1beta transcription by Epstein-Barr virus involves a number of latent proteins via their interaction with RBP.
1	Regulation	regulation	NOUN	NN	Number=Sing	_	_	_	_
2	of	of	ADP	IN	_	_	_	_	_
3	interleukin	interleukin	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
4	-1	-1	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
5	beta	beta	NOUN	NN	Number=Sing	_	_	_	_
6	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
7	by	by	ADP	IN	_	_	_	_	_
8	Epstein	Epstein	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
9	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
10	Barr	Barr	PROPN	NNP	Number=Sing	_	_	_	_
11	virus	virus	NOUN	NN	Number=Sing	_	_	_	_
12	involves	involve	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
13	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
14	number	number	NOUN	NN	Number=Sing	_	_	_	_
15	of	of	ADP	IN	_	_	_	_	_
16	latent	latent	ADJ	JJ	Degree=Pos	_	_	_	_
17	proteins	protein	NOUN	NNS	Number=Plur	_	_	_	_
18	via	via	ADP	IN	_	_	_	_	_
19	their	they	PRON	PRP$	Number=Plur|Person=3|Poss=Yes|PronType=Prs	_	_	_	_
20	interaction	interaction	NOUN	NN	Number=Sing	_	_	_	_
21	with	with	ADP	IN	_	_	_	_	_
22	RBP	RBP	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
23	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 177
# text = Epstein-Barr virus (EBV) infects B cells, resulting in the outgrowth of immortalised lymphoblastoid cell lines (LCLs).
1	Epstein	Epstein	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
2	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
3	Barr	Barr	PROPN	NNP	Number=Sing	_	_	_	_
4	virus	virus	NOUN	NN	Number=Sing	_	_	_	_
5	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
6	EBV	EBV	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
7	)	)	PUNCT	-RRB-	_	_	_	_	_
8	infects	infect	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
9	B	b	ADJ	JJ	Degree=Pos	_	_	_	_
10	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
11	,	,	PUNCT	,	_	_	_	_	_
12	resulting	result	VERB	VBG	VerbForm=Ger	_	_	_	_
13	in	in	ADP	IN	_	_	_	_	_
14	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
15	outgrowth	outgrowth	NOUN	NN	Number=Sing	_	_	_	_
16	of	of	ADP	IN	_	_	_	_	_
17	immortalised	immortalise	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
18	lymphoblastoid	lymphoblastoid	NOUN	NN	Number=Sing	_	_	_	_
19	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
20	lines	line	NOUN	NNS	Number=Plur	_	_	_	_
21	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
22	LCLs	LCL	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
23	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
24	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 178
# text = Here, we demonstrate through the use of intracellular staining that interleukin-1beta (IL-1beta) is expressed in LCLs and investigate the influence of the individual latent proteins on the expression of IL-1beta.
1	Here	here	ADV	RB	PronType=Dem	_	_	_	SpaceAfter=No
2	,	,	PUNCT	,	_	_	_	_	_
3	we	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
4	demonstrate	demonstrate	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
5	through	through	ADP	IN	_	_	_	_	_
6	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
7	use	use	NOUN	NN	Number=Sing	_	_	_	_
8	of	of	ADP	IN	_	_	_	_	_
9	intracellular	intracellular	ADJ	JJ	Degree=Pos	_	_	_	_
10	staining	staining	NOUN	NN	Number=Sing	_	_	_	_
11	that	that	PRON	WDT	PronType=Rel	_	_	_	_
12	interleukin	interleukin	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	SpaceAfter=No
13	-1	-1	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
14	beta	beta	NOUN	NN	Number=Sing	_	_	_	_
15	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
16	IL	Il	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
17	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
18	1	1	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
19	beta	beta	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
20	)	)	PUNCT	-RRB-	_	_	_	_	_
21	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
22	expressed	express	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
23	in	in	ADP	IN	_	_	_	_	_
24	LCLs	LCLs	NOUN	NNS	Number=Plur	_	_	_	_
25	and	and	CCONJ	CC	_	_	_	_	_
26	investigate	investigate	VERB	VB	VerbForm=Inf	_	_	_	_
27	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
28	influence	influence	NOUN	NN	Number=Sing	_	_	_	_
29	of	of	ADP	IN	_	_	_	_	_
30	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
31	individual	individual	ADJ	JJ	Degree=Pos	_	_	_	_
32	latent	latent	ADJ	JJ	Degree=Pos	_	_	_	_
33	proteins	protein	NOUN	NNS	Number=Plur	_	_	_	_
34	on	on	ADP	IN	_	_	_	_	_
35	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
36	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
37	of	of	ADP	IN	_	_	_	_	_
38	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
39	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
40	1	1	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
41	beta	beta	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
42	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 179
# text = Using RT-PCR, IL-1beta was shown to be up-regulated in EBV-transformed LCLs as well as in group III Burkitt's lymphoma (BL) cell lines, compared with group I BL cell lines.
1	Using	use	VERB	VBG	VerbForm=Ger	_	_	_	_
2	RT	Rt	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
3	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
4	PCR	PCR	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
5	,	,	PUNCT	,	_	_	_	_	_
6	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
7	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
8	1	1	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
9	beta	beta	NOUN	NN	Number=Sing	_	_	_	_
10	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
11	shown	show	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
12	to	to	PART	TO	_	_	_	_	_
13	be	be	AUX	VB	VerbForm=Inf	_	_	_	_
14	up	up	ADP	IN	_	_	_	_	SpaceAfter=No
15	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
16	regulated	regulate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
17	in	in	ADP	IN	_	_	_	_	_
18	EBV	EBV	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
19	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
20	transformed	transform	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
21	LCLs	LCL	NOUN	NNS	Number=Plur	_	_	_	_
22	as	as	ADV	RB	_	_	_	_	_
23	well	well	ADV	RB	Degree=Pos	_	_	_	_
24	as	as	ADP	IN	_	_	_	_	_
25	in	in	ADP	IN	_	_	_	_	_
26	group	group	NOUN	NN	Number=Sing	_	_	_	_
27	III	iii	PROPN	NNP	Number=Sing	_	_	_	_
28	Burkitt	Burkitt	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
29	's	's	PART	POS	_	_	_	_	_
30	lymphoma	lymphoma	NOUN	NN	Number=Sing	_	_	_	_
31	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
32	BL	BL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
33	)	)	PUNCT	-RRB-	_	_	_	_	_
34	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
35	lines	line	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
36	,	,	PUNCT	,	_	_	_	_	_
37	compared	compare	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
38	with	with	ADP	IN	_	_	_	_	_
39	group	group	NOUN	NN	Number=Sing	_	_	_	_
40	I	I	PRON	PRP	Case=Nom|Number=Sing|Person=1|PronType=Prs	_	_	_	_
41	BL	Bl	AUX	MD	VerbForm=Fin	_	_	_	_
42	cell	cell	VERB	VB	VerbForm=Inf	_	_	_	_
43	lines	line	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
44	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 180
# text = The up-regulation of IL-1beta message could be mediated by the latent membrane protein-1, EBV nuclear proteins 2, 3, 4, and 6 genes.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	up	up	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
3	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
4	regulation	regulation	NOUN	NN	Number=Sing	_	_	_	_
5	of	of	ADP	IN	_	_	_	_	_
6	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
7	-1	-1	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
8	beta	beta	NOUN	NN	Number=Sing	_	_	_	_
9	message	message	NOUN	NN	Number=Sing	_	_	_	_
10	could	could	AUX	MD	VerbForm=Fin	_	_	_	_
11	be	be	AUX	VB	VerbForm=Inf	_	_	_	_
12	mediated	mediate	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
13	by	by	ADP	IN	_	_	_	_	_
14	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
15	latent	latent	ADJ	JJ	Degree=Pos	_	_	_	_
16	membrane	membrane	NOUN	NN	Number=Sing	_	_	_	_
17	protein	protein	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
18	-1	-1	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
19	,	,	PUNCT	,	_	_	_	_	_
20	EBV	EBV	VERB	VBP	Abbr=Yes|Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
21	nuclear	nuclear	ADJ	JJ	Degree=Pos	_	_	_	_
22	proteins	protein	NOUN	NNS	Number=Plur	_	_	_	_
23	2	2	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
24	,	,	PUNCT	,	_	_	_	_	_
25	3	3	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
26	,	,	PUNCT	,	_	_	_	_	_
27	4	4	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
28	,	,	PUNCT	,	_	_	_	_	_
29	and	and	CCONJ	CC	_	_	_	_	_
30	6	6	NUM	CD	NumType=Card	_	_	_	_
31	genes	gene	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
32	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 181
# text = Electrophoretic mobility shift assays (EMSAs) demonstrated that the -300 region of the IL-1beta promoter, which contains a nuclear factor-kappaB (NF-kappaB) binding site, contained a functional RBP binding site.
1	Electrophoretic	Electrophoretic	ADJ	JJ	Degree=Pos	_	_	_	_
2	mobility	mobility	NOUN	NN	Number=Sing	_	_	_	_
3	shift	shift	NOUN	NN	Number=Sing	_	_	_	_
4	assays	assay	NOUN	NNS	Number=Plur	_	_	_	_
5	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
6	EMSAs	EMSAs	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
7	)	)	PUNCT	-RRB-	_	_	_	_	_
8	demonstrated	demonstrate	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
9	that	that	SCONJ	IN	_	_	_	_	_
10	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
11	-	-	SYM	SYM	_	_	_	_	SpaceAfter=No
12	300	300	NUM	CD	NumType=Card	_	_	_	_
13	region	region	NOUN	NN	Number=Sing	_	_	_	_
14	of	of	ADP	IN	_	_	_	_	_
15	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
16	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
17	-1	-1	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
18	beta	beta	NOUN	NN	Number=Sing	_	_	_	_
19	promoter	promoter	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
20	,	,	PUNCT	,	_	_	_	_	_
21	which	which	PRON	WDT	PronType=Rel	_	_	_	_
22	contains	contain	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
23	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
24	nuclear	nuclear	ADJ	JJ	Degree=Pos	_	_	_	_
25	factor	factor	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
26	-kappaB	-kappaB	PROPN	NNP	Number=Sing	_	_	_	_
27	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
28	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
29	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
30	kappaB	kappaB	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
31	)	)	PUNCT	-RRB-	_	_	_	_	_
32	binding	bind	VERB	VBG	VerbForm=Ger	_	_	_	_
33	site	site	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
34	,	,	PUNCT	,	_	_	_	_	_
35	contained	contain	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
36	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
37	functional	functional	ADJ	JJ	Degree=Pos	_	_	_	_
38	RBP	Rbp	PROPN	NNP	Number=Sing	_	_	_	_
39	binding	bind	VERB	VBG	VerbForm=Ger	_	_	_	_
40	site	site	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
41	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 182
# text = Binding of RBP to this site could be inhibited by addition of EBV nuclear proteins 3 and 6, suggesting that these proteins displace RBP from its recognition sequence, removing transcriptional repression and allowing gene transcription to occur.
1	Binding	binding	NOUN	NN	Number=Sing	_	_	_	_
2	of	of	ADP	IN	_	_	_	_	_
3	RBP	RBP	PROPN	NNP	Number=Sing	_	_	_	_
4	to	to	ADP	IN	_	_	_	_	_
5	this	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
6	site	site	NOUN	NN	Number=Sing	_	_	_	_
7	could	could	AUX	MD	VerbForm=Fin	_	_	_	_
8	be	be	AUX	VB	VerbForm=Inf	_	_	_	_
9	inhibited	inhibit	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
10	by	by	ADP	IN	_	_	_	_	_
11	addition	addition	NOUN	NN	Number=Sing	_	_	_	_
12	of	of	ADP	IN	_	_	_	_	_
13	EBV	EBV	PROPN	NNP	Number=Sing	_	_	_	_
14	nuclear	nuclear	ADJ	JJ	Degree=Pos	_	_	_	_
15	proteins	protein	NOUN	NNS	Number=Plur	_	_	_	_
16	3	3	NUM	CD	NumType=Card	_	_	_	_
17	and	and	CCONJ	CC	_	_	_	_	_
18	6	6	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
19	,	,	PUNCT	,	_	_	_	_	_
20	suggesting	suggest	VERB	VBG	VerbForm=Ger	_	_	_	_
21	that	that	SCONJ	IN	_	_	_	_	_
22	these	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
23	proteins	protein	NOUN	NNS	Number=Plur	_	_	_	_
24	displace	displace	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
25	RBP	Rbp	PROPN	NNP	Number=Sing	_	_	_	_
26	from	from	ADP	IN	_	_	_	_	_
27	its	its	PRON	PRP$	Gender=Neut|Number=Sing|Person=3|Poss=Yes|PronType=Prs	_	_	_	_
28	recognition	recognition	NOUN	NN	Number=Sing	_	_	_	_
29	sequence	sequence	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
30	,	,	PUNCT	,	_	_	_	_	_
31	removing	remove	VERB	VBG	VerbForm=Ger	_	_	_	_
32	transcriptional	transcriptional	ADJ	JJ	Degree=Pos	_	_	_	_
33	repression	repression	NOUN	NN	Number=Sing	_	_	_	_
34	and	and	CCONJ	CC	_	_	_	_	_
35	allowing	allow	VERB	VBG	VerbForm=Ger	_	_	_	_
36	gene	gene	ADJ	JJ	Degree=Pos	_	_	_	_
37	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
38	to	to	PART	TO	_	_	_	_	_
39	occur	occur	VERB	VB	VerbForm=Inf	_	_	_	SpaceAfter=No
40	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 183
# text = In group I BL cells, containing low levels of NF-kappaB, only RBP binding was observed in EMSAs, whereas NF-kappaB binding could be demonstrated in EBV-transformed B cell lines containing high levels of activated NF-kappaB.
1	In	in	ADP	IN	_	_	_	_	_
2	group	group	NOUN	NN	Number=Sing	_	_	_	_
3	I	I	PRON	PRP	Case=Nom|Number=Sing|Person=1|PronType=Prs	_	_	_	_
4	BL	Bl	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
5	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
6	,	,	PUNCT	,	_	_	_	_	_
7	containing	contain	VERB	VBG	VerbForm=Ger	_	_	_	_
8	low	low	ADJ	JJ	Degree=Pos	_	_	_	_
9	levels	level	NOUN	NNS	Number=Plur	_	_	_	_
10	of	of	ADP	IN	_	_	_	_	_
11	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
12	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
13	kappaB	kappaB	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
14	,	,	PUNCT	,	_	_	_	_	_
15	only	only	ADV	RB	_	_	_	_	_
16	RBP	RBP	PROPN	NNP	Number=Sing	_	_	_	_
17	binding	binding	VERB	VBG	VerbForm=Ger	_	_	_	_
18	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
19	observed	observe	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
20	in	in	ADP	IN	_	_	_	_	_
21	EMSAs	EMSAs	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
22	,	,	PUNCT	,	_	_	_	_	_
23	whereas	whereas	SCONJ	IN	_	_	_	_	_
24	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
25	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
26	kappaB	kappaB	PROPN	NNP	Number=Sing	_	_	_	_
27	binding	binding	VERB	VBG	Tense=Pres|VerbForm=Part	_	_	_	_
28	could	could	AUX	MD	VerbForm=Fin	_	_	_	_
29	be	be	AUX	VB	VerbForm=Inf	_	_	_	_
30	demonstrated	demonstrate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
31	in	in	ADP	IN	_	_	_	_	_
32	EBV	EBV	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
33	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
34	transformed	transform	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
35	B	b	NOUN	NN	Number=Sing	_	_	_	_
36	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
37	lines	line	NOUN	NNS	Number=Plur	_	_	_	_
38	containing	contain	VERB	VBG	VerbForm=Ger	_	_	_	_
39	high	high	ADJ	JJ	Degree=Pos	_	_	_	_
40	levels	level	NOUN	NNS	Number=Plur	_	_	_	_
41	of	of	ADP	IN	_	_	_	_	_
42	activated	activate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
43	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
44	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
45	kappaB	kappaB	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
46	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 184
# text = In addition, the expression of latent membrane protein-1 led to activation of NF-kappaB that was capable of binding the IL-1beta promoter.
1	In	in	ADP	IN	_	_	_	_	_
2	addition	addition	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
3	,	,	PUNCT	,	_	_	_	_	_
4	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
5	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
6	of	of	ADP	IN	_	_	_	_	_
7	latent	latent	ADJ	JJ	Degree=Pos	_	_	_	_
8	membrane	membrane	NOUN	NN	Number=Sing	_	_	_	_
9	protein	protein	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
10	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
11	1	1	NUM	CD	NumType=Card	_	_	_	_
12	led	lead	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
13	to	to	ADP	IN	_	_	_	_	_
14	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
15	of	of	ADP	IN	_	_	_	_	_
16	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
17	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
18	kappaB	kappaB	PROPN	NNP	Number=Sing	_	_	_	_
19	that	that	PRON	WDT	PronType=Rel	_	_	_	_
20	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
21	capable	capable	ADJ	JJ	Degree=Pos	_	_	_	_
22	of	of	SCONJ	IN	_	_	_	_	_
23	binding	bind	VERB	VBG	VerbForm=Ger	_	_	_	_
24	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
25	IL	Il	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
26	-1	-1	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
27	beta	beta	NOUN	NN	Number=Sing	_	_	_	_
28	promoter	promoter	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
29	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 185
# text = The study demonstrates that EBV can up-regulate IL-1beta expression, possibly by using RBP, NF-kappaB, or both.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	study	study	NOUN	NN	Number=Sing	_	_	_	_
3	demonstrates	demonstrate	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
4	that	that	SCONJ	IN	_	_	_	_	_
5	EBV	EBV	PROPN	NNP	Number=Sing	_	_	_	_
6	can	can	AUX	MD	VerbForm=Fin	_	_	_	_
7	up	up	ADV	RB	_	_	_	_	SpaceAfter=No
8	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
9	regulate	regulate	VERB	VB	VerbForm=Inf	_	_	_	_
10	IL	Il	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
11	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
12	1	1	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
13	beta	beta	NOUN	NN	Number=Sing	_	_	_	_
14	expression	expression	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
15	,	,	PUNCT	,	_	_	_	_	_
16	possibly	possibly	ADV	RB	_	_	_	_	_
17	by	by	SCONJ	IN	_	_	_	_	_
18	using	use	VERB	VBG	VerbForm=Ger	_	_	_	_
19	RBP	RBP	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
20	,	,	PUNCT	,	_	_	_	_	_
21	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
22	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
23	kappaB	kappaB	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
24	,	,	PUNCT	,	_	_	_	_	_
25	or	or	CCONJ	CC	_	_	_	_	_
26	both	both	DET	DT	_	_	_	_	SpaceAfter=No
27	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 186
# text = Copyright 1998 Academic Press.
1	Copyright	copyright	NOUN	NN	Number=Sing	_	_	_	_
2	1998	1998	NUM	CD	NumType=Card	_	_	_	_
3	Academic	academic	PROPN	NNP	Number=Sing	_	_	_	_
4	Press	Press	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
5	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 187
# text = Document 00300256 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	00300256	00300256	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 188
# text = Essential role of alveolar macrophages in intrapulmonary activation of NF-kappaB.
1	Essential	essential	ADJ	JJ	Degree=Pos	_	_	_	_
2	role	role	NOUN	NN	Number=Sing	_	_	_	_
3	of	of	ADP	IN	_	_	_	_	_
4	alveolar	alveolar	ADJ	JJ	Degree=Pos	_	_	_	_
5	macrophages	macrophage	NOUN	NNS	Number=Plur	_	_	_	_
6	in	in	ADP	IN	_	_	_	_	_
7	intrapulmonary	intrapulmonary	ADJ	JJ	Degree=Pos	_	_	_	_
8	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
9	of	of	ADP	IN	_	_	_	_	_
10	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
11	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
12	kappaB	kappaB	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
13	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 189
# text = Acute inflammatory injury in rat lung induced by deposition of immunoglobulin G immune complexes requires expression of cytokines and chemokines as well as activation of the transcription factor nuclear factor (NF)-kappaB.
1	Acute	Acute	ADV	RB	_	_	_	_	_
2	inflammatory	inflammatory	ADJ	JJ	Degree=Pos	_	_	_	_
3	injury	injury	NOUN	NN	Number=Sing	_	_	_	_
4	in	in	ADP	IN	_	_	_	_	_
5	rat	rat	NOUN	NN	Number=Sing	_	_	_	_
6	lung	lung	NOUN	NN	Number=Sing	_	_	_	_
7	induced	induce	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
8	by	by	ADP	IN	_	_	_	_	_
9	deposition	deposition	NOUN	NN	Number=Sing	_	_	_	_
10	of	of	ADP	IN	_	_	_	_	_
11	immunoglobulin	immunoglobulin	ADJ	JJ	Degree=Pos	_	_	_	_
12	G	g	NOUN	NN	Number=Sing	_	_	_	_
13	immune	immune	PRON	PRP	_	_	_	_	_
14	complexes	complexe	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
15	requires	require	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
16	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
17	of	of	ADP	IN	_	_	_	_	_
18	cytokines	cytokine	NOUN	NNS	Number=Plur	_	_	_	_
19	and	and	CCONJ	CC	_	_	_	_	_
20	chemokines	chemokine	NOUN	NNS	Number=Plur	_	_	_	_
21	as	as	ADV	RB	_	_	_	_	_
22	well	well	ADV	RB	Degree=Pos	_	_	_	_
23	as	as	ADP	IN	_	_	_	_	_
24	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
25	of	of	ADP	IN	_	_	_	_	_
26	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
27	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
28	factor	factor	NOUN	NN	Number=Sing	_	_	_	_
29	nuclear	nuclear	ADJ	JJ	Degree=Pos	_	_	_	_
30	factor	factor	NOUN	NN	Number=Sing	_	_	_	_
31	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
32	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
33	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
34	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
35	kappaB	kappaB	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
36	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 190
# text = There is little direct evidence regarding the role of alveolar macrophages in these activation events.
1	There	there	PRON	EX	_	_	_	_	_
2	is	be	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
3	little	little	ADJ	JJ	Degree=Pos	_	_	_	_
4	direct	direct	ADJ	JJ	Degree=Pos	_	_	_	_
5	evidence	evidence	NOUN	NN	Number=Sing	_	_	_	_
6	regarding	regard	VERB	VBG	VerbForm=Ger	_	_	_	_
7	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
8	role	role	NOUN	NN	Number=Sing	_	_	_	_
9	of	of	ADP	IN	_	_	_	_	_
10	alveolar	alveolar	ADJ	JJ	Degree=Pos	_	_	_	_
11	macrophages	macrophage	NOUN	NNS	Number=Plur	_	_	_	_
12	in	in	ADP	IN	_	_	_	_	_
13	these	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
14	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
15	events	event	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
16	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 191
# text = In the present studies, rat lungs were depleted of alveolar macrophages by airway instillation of liposome-encapsulated dichloromethylene diphosphonate.
1	In	in	ADP	IN	_	_	_	_	_
2	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
3	present	present	ADJ	JJ	Degree=Pos	_	_	_	_
4	studies	study	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
5	,	,	PUNCT	,	_	_	_	_	_
6	rat	rat	NOUN	NN	Number=Sing	_	_	_	_
7	lungs	lung	NOUN	NNS	Number=Plur	_	_	_	_
8	were	be	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
9	depleted	deplet	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
10	of	of	ADP	IN	_	_	_	_	_
11	alveolar	alveolar	ADJ	JJ	Degree=Pos	_	_	_	_
12	macrophages	macrophage	NOUN	NNS	Number=Plur	_	_	_	_
13	by	by	ADP	IN	_	_	_	_	_
14	airway	airway	NOUN	NN	Number=Sing	_	_	_	_
15	instillation	instillation	NOUN	NN	Number=Sing	_	_	_	_
16	of	of	ADP	IN	_	_	_	_	_
17	liposome	liposome	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
18	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
19	encapsulated	encapsulate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
20	dichloromethylene	dichloromethylene	NOUN	NN	Number=Sing	_	_	_	_
21	diphosphonate	diphosphonate	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
22	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 192
# text = These procedures, which greatly reduced the number of retrievable alveolar macrophages, suppressed activation of lung NF-kappaB in the inflammatory model.
1	These	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
2	procedures	procedure	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
3	,	,	PUNCT	,	_	_	_	_	_
4	which	which	PRON	WDT	PronType=Rel	_	_	_	_
5	greatly	greatly	ADV	RB	_	_	_	_	_
6	reduced	reduce	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
7	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
8	number	number	NOUN	NN	Number=Sing	_	_	_	_
9	of	of	ADP	IN	_	_	_	_	_
10	retrievable	retrievable	ADJ	JJ	Degree=Pos	_	_	_	_
11	alveolar	alveolar	NOUN	NN	Number=Sing	_	_	_	_
12	macrophages	macrophage	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
13	,	,	PUNCT	,	_	_	_	_	_
14	suppressed	suppress	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
15	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
16	of	of	ADP	IN	_	_	_	_	_
17	lung	lung	NOUN	NN	Number=Sing	_	_	_	_
18	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
19	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
20	kappaB	kappaB	PROPN	NNP	Number=Sing	_	_	_	_
21	in	in	ADP	IN	_	_	_	_	_
22	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
23	inflammatory	inflammatory	ADJ	JJ	Degree=Pos	_	_	_	_
24	model	model	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
25	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 193
# text = In addition, bronchoalveolar lavage levels of tumor necrosis factor-alpha (TNF-alpha) and the CXC chemokine, macrophage inflammatory protein-2, were substantially reduced.
1	In	in	ADP	IN	_	_	_	_	_
2	addition	addition	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
3	,	,	PUNCT	,	_	_	_	_	_
4	bronchoalveolar	bronchoalveolar	ADJ	JJ	Degree=Pos	_	_	_	_
5	lavage	lavage	NOUN	NN	Number=Sing	_	_	_	_
6	levels	level	NOUN	NNS	Number=Plur	_	_	_	_
7	of	of	ADP	IN	_	_	_	_	_
8	tumor	tumor	NOUN	NN	Number=Sing	_	_	_	_
9	necrosis	necrosis	NOUN	NN	Number=Sing	_	_	_	_
10	factor	factor	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
11	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
12	alpha	alpha	NOUN	NN	Number=Sing	_	_	_	_
13	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
14	TNF	Tnf	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
15	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
16	alpha	alpha	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
17	)	)	PUNCT	-RRB-	_	_	_	_	_
18	and	and	CCONJ	CC	_	_	_	_	_
19	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
20	CXC	CXC	PROPN	NNP	Number=Sing	_	_	_	_
21	chemokine	chemokine	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
22	,	,	PUNCT	,	_	_	_	_	_
23	macrophage	macrophage	NOUN	NN	Number=Sing	_	_	_	_
24	inflammatory	inflammatory	ADJ	JJ	Degree=Pos	_	_	_	_
25	protein	protein	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
26	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
27	2	2	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
28	,	,	PUNCT	,	_	_	_	_	_
29	were	be	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
30	substantially	substantially	ADV	RB	_	_	_	_	_
31	reduced	reduce	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	SpaceAfter=No
32	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 194
# text = In parallel, upregulation of the lung vascular adhesion molecule, intercellular adhesion molecule-1, was greatly reduced by intrapulmonary instillation of phosphonate-containing liposomes.
1	In	in	ADP	IN	_	_	_	_	_
2	parallel	parallel	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
3	,	,	PUNCT	,	_	_	_	_	_
4	upregulation	upregulation	NOUN	NN	Number=Sing	_	_	_	_
5	of	of	ADP	IN	_	_	_	_	_
6	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
7	lung	lung	ADJ	JJ	Degree=Pos	_	_	_	_
8	vascular	vascular	ADJ	JJ	Degree=Pos	_	_	_	_
9	adhesion	adhesion	NOUN	NN	Number=Sing	_	_	_	_
10	molecule	molecule	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
11	,	,	PUNCT	,	_	_	_	_	_
12	intercellular	intercellular	ADJ	JJ	Degree=Pos	_	_	_	_
13	adhesion	adhesion	NOUN	NN	Number=Sing	_	_	_	_
14	molecule	molecule	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
15	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
16	1	1	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
17	,	,	PUNCT	,	_	_	_	_	_
18	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
19	greatly	greatly	ADV	RB	_	_	_	_	_
20	reduced	reduce	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
21	by	by	ADP	IN	_	_	_	_	_
22	intrapulmonary	intrapulmonary	ADJ	JJ	Degree=Pos	_	_	_	_
23	instillation	instillation	NOUN	NN	Number=Sing	_	_	_	_
24	of	of	ADP	IN	_	_	_	_	_
25	phosphonate	phosphonate	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
26	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
27	containing	contain	VERB	VBG	VerbForm=Ger	_	_	_	_
28	liposomes	liposome	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
29	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 195
# text = Neutrophil accumulation and development of lung injury were also substantially diminished.
1	Neutrophil	Neutrophil	ADJ	JJ	Degree=Pos	_	_	_	_
2	accumulation	accumulation	NOUN	NN	Number=Sing	_	_	_	_
3	and	and	CCONJ	CC	_	_	_	_	_
4	development	development	NOUN	NN	Number=Sing	_	_	_	_
5	of	of	ADP	IN	_	_	_	_	_
6	lung	lung	NOUN	NN	Number=Sing	_	_	_	_
7	injury	injury	NOUN	NN	Number=Sing	_	_	_	_
8	were	be	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
9	also	also	ADV	RB	_	_	_	_	_
10	substantially	substantially	ADV	RB	_	_	_	_	_
11	diminished	diminish	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	SpaceAfter=No
12	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 196
# text = Lung instillation of TNF-alpha in alveolar macrophage-depleted rats restored the NF-kappaB activation response in whole lung.
1	Lung	lung	ADJ	JJ	Degree=Pos	_	_	_	_
2	instillation	instillation	NOUN	NN	Number=Sing	_	_	_	_
3	of	of	ADP	IN	_	_	_	_	_
4	TNF	TNF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
5	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
6	alpha	alpha	NOUN	NN	Number=Sing	_	_	_	_
7	in	in	ADP	IN	_	_	_	_	_
8	alveolar	alveolar	ADJ	JJ	Degree=Pos	_	_	_	_
9	macrophage	macrophage	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
10	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
11	depleted	deplet	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
12	rats	rat	NOUN	NNS	Number=Plur	_	_	_	_
13	restored	restore	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
14	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
15	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
16	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
17	kappaB	kappaB	PROPN	NNP	Number=Sing	_	_	_	_
18	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
19	response	response	NOUN	NN	Number=Sing	_	_	_	_
20	in	in	ADP	IN	_	_	_	_	_
21	whole	whole	ADJ	JJ	Degree=Pos	_	_	_	_
22	lung	lung	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
23	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 197
# text = These data suggest that, in this inflammatory model, initial activation of NF-kappaB occurs in alveolar macrophages and the ensuing production of TNF-alpha may propagate NF-kappaB activation to other cell types in the lung.
1	These	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
2	data	data	NOUN	NN	Number=Sing	_	_	_	_
3	suggest	suggest	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
4	that	that	PRON	DT	Number=Sing|PronType=Dem	_	_	_	SpaceAfter=No
5	,	,	PUNCT	,	_	_	_	_	_
6	in	in	ADP	IN	_	_	_	_	_
7	this	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
8	inflammatory	inflammatory	ADJ	JJ	Degree=Pos	_	_	_	_
9	model	model	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
10	,	,	PUNCT	,	_	_	_	_	_
11	initial	initial	ADJ	JJ	Degree=Pos	_	_	_	_
12	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
13	of	of	ADP	IN	_	_	_	_	_
14	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
15	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
16	kappaB	kappaB	PROPN	NNP	Number=Sing	_	_	_	_
17	occurs	occur	NOUN	NNS	Number=Plur	_	_	_	_
18	in	in	ADP	IN	_	_	_	_	_
19	alveolar	alveolar	ADJ	JJ	Degree=Pos	_	_	_	_
20	macrophages	macrophage	NOUN	NNS	Number=Plur	_	_	_	_
21	and	and	CCONJ	CC	_	_	_	_	_
22	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
23	ensuing	ensue	VERB	VBG	VerbForm=Ger	_	_	_	_
24	production	production	NOUN	NN	Number=Sing	_	_	_	_
25	of	of	ADP	IN	_	_	_	_	_
26	TNF	TNF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
27	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
28	alpha	alpha	PROPN	NNP	Number=Sing	_	_	_	_
29	may	may	AUX	MD	VerbForm=Fin	_	_	_	_
30	propagate	propagate	VERB	VB	VerbForm=Inf	_	_	_	_
31	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
32	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
33	kappaB	kappaB	PROPN	NNP	Number=Sing	_	_	_	_
34	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
35	to	to	ADP	IN	_	_	_	_	_
36	other	other	ADJ	JJ	Degree=Pos	_	_	_	_
37	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
38	types	type	NOUN	NNS	Number=Plur	_	_	_	_
39	in	in	ADP	IN	_	_	_	_	_
40	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
41	lung	lung	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
42	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 198
# text = Document 00300258 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	00300258	00300258	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 199
# text = Suppression of MHC class II expression by human class II trans-activator constructs lacking the N-terminal domain.
1	Suppression	Suppression	NOUN	NN	Number=Sing	_	_	_	_
2	of	of	ADP	IN	_	_	_	_	_
3	MHC	MHC	PROPN	NNP	Number=Sing	_	_	_	_
4	class	class	NOUN	NN	Number=Sing	_	_	_	_
5	II	ii	NUM	CD	NumType=Card	_	_	_	_
6	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
7	by	by	ADP	IN	_	_	_	_	_
8	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
9	class	class	NOUN	NN	Number=Sing	_	_	_	_
10	II	ii	NUM	CD	NumType=Card	_	_	_	_
11	trans	tran	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
12	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
13	activator	activator	NOUN	NN	Number=Sing	_	_	_	_
14	constructs	construct	NOUN	NNS	Number=Plur	_	_	_	_
15	lacking	lack	VERB	VBG	VerbForm=Ger	_	_	_	_
16	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
17	N-	n-	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
18	terminal	terminal	NOUN	NN	Number=Sing	_	_	_	_
19	domain	domain	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
20	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 200
# text = The class II trans-activator (CIITA) is a bi- or multi-functional domain protein which plays a critical role in the expression of MHC class II genes.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	class	class	NOUN	NN	Number=Sing	_	_	_	_
3	II	ii	NUM	CD	NumType=Card	_	_	_	_
4	trans	tran	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
5	-	-	PUNCT	:	_	_	_	_	SpaceAfter=No
6	activator	activator	NOUN	NN	Number=Sing	_	_	_	_
7	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
8	CIITA	CIITA	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
9	)	)	PUNCT	-RRB-	_	_	_	_	_
10	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
11	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
12	bi	bi	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
13	-	-	PUNCT	,	_	_	_	_	_
14	or	or	CCONJ	CC	_	_	_	_	_
15	multi-functional	multi-functional	ADJ	JJ	Degree=Pos	_	_	_	_
16	domain	domain	NOUN	NN	Number=Sing	_	_	_	_
17	protein	protein	NOUN	NN	Number=Sing	_	_	_	_
18	which	which	PRON	WDT	PronType=Rel	_	_	_	_
19	plays	play	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
20	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
21	critical	critical	ADJ	JJ	Degree=Pos	_	_	_	_
22	role	role	NOUN	NN	Number=Sing	_	_	_	_
23	in	in	ADP	IN	_	_	_	_	_
24	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
25	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
26	of	of	ADP	IN	_	_	_	_	_
27	MHC	MHC	PROPN	NNP	Number=Sing	_	_	_	_
28	class	class	NOUN	NN	Number=Sing	_	_	_	_
29	II	ii	NUM	CD	NumType=Card	_	_	_	_
30	genes	gene	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
31	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 201
# text = We report that removal of the N-terminal 151 amino acids, encompassing all of the acidic domain but leaving intact the proline/serine/threonine-rich domain, results in a mutant protein with potent suppressive properties for MHC class II expression.
1	We	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
2	report	report	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
3	that	that	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
4	removal	removal	NOUN	NN	Number=Sing	_	_	_	_
5	of	of	ADP	IN	_	_	_	_	_
6	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
7	N-	n-	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
8	terminal	terminal	NOUN	NN	Number=Sing	_	_	_	_
9	151	151	NUM	CD	NumType=Card	_	_	_	_
10	amino	amino	NOUN	NN	Number=Sing	_	_	_	_
11	acids	acid	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
12	,	,	PUNCT	,	_	_	_	_	_
13	encompassing	encompasse	VERB	VBG	VerbForm=Ger	_	_	_	_
14	all	all	DET	DT	_	_	_	_	_
15	of	of	ADP	IN	_	_	_	_	_
16	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
17	acidic	acidic	ADJ	JJ	Degree=Pos	_	_	_	_
18	domain	domain	NOUN	NN	Number=Sing	_	_	_	_
19	but	but	CCONJ	CC	_	_	_	_	_
20	leaving	leave	VERB	VBG	VerbForm=Ger	_	_	_	_
21	intact	intact	ADV	RB	_	_	_	_	_
22	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
23	proline	proline	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
24	/	/	PUNCT	,	_	_	_	_	SpaceAfter=No
25	serine/threonine-rich	serine/threonine-rich	NOUN	NN	Number=Sing	_	_	_	_
26	domain	domain	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
27	,	,	PUNCT	,	_	_	_	_	_
28	results	result	NOUN	NNS	Number=Plur	_	_	_	_
29	in	in	ADP	IN	_	_	_	_	_
30	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
31	mutant	mutant	ADJ	JJ	Degree=Pos	_	_	_	_
32	protein	protein	NOUN	NN	Number=Sing	_	_	_	_
33	with	with	ADP	IN	_	_	_	_	_
34	potent	potent	NOUN	NN	Number=Sing	_	_	_	_
35	suppressive	suppressive	ADJ	JJ	Degree=Pos	_	_	_	_
36	properties	property	NOUN	NNS	Number=Plur	_	_	_	_
37	for	for	ADP	IN	_	_	_	_	_
38	MHC	MHC	PROPN	NNP	Number=Sing	_	_	_	_
39	class	class	NOUN	NN	Number=Sing	_	_	_	_
40	II	ii	NUM	CD	NumType=Card	_	_	_	_
41	expression	expression	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
42	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 202
# text = HeLa cells stably or transiently transfected with mutant CIITA constructs showed up to 99% suppression of MHC class II antigen induction by IFN-gamma and marked suppression of HLA-DRA mRNA expression.
1	HeLa	Hela	PROPN	NNP	Number=Sing	_	_	_	_
2	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
3	stably	stably	ADV	RB	_	_	_	_	_
4	or	or	CCONJ	CC	_	_	_	_	_
5	transiently	transiently	ADV	RB	_	_	_	_	_
6	transfected	transfect	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
7	with	with	ADP	IN	_	_	_	_	_
8	mutant	mutant	ADJ	JJ	Degree=Pos	_	_	_	_
9	CIITA	CIITA	PROPN	NNP	Number=Sing	_	_	_	_
10	constructs	construct	NOUN	NNS	Number=Plur	_	_	_	_
11	showed	show	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
12	up	up	ADP	RP	_	_	_	_	_
13	to	to	ADP	IN	_	_	_	_	_
14	99	99	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
15	%	%	SYM	NN	Number=Sing	_	_	_	_
16	suppression	suppression	NOUN	NN	Number=Sing	_	_	_	_
17	of	of	ADP	IN	_	_	_	_	_
18	MHC	MHC	PROPN	NNP	Number=Sing	_	_	_	_
19	class	class	NOUN	NN	Number=Sing	_	_	_	_
20	II	ii	NUM	CD	NumType=Card	_	_	_	_
21	antigen	antigen	NUM	CD	NumType=Card	_	_	_	_
22	induction	induction	NOUN	NN	Number=Sing	_	_	_	_
23	by	by	ADP	IN	_	_	_	_	_
24	IFN	IFN	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
25	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
26	gamma	gamma	NOUN	NN	Number=Sing	_	_	_	_
27	and	and	CCONJ	CC	_	_	_	_	_
28	marked	mark	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
29	suppression	suppression	NOUN	NN	Number=Sing	_	_	_	_
30	of	of	ADP	IN	_	_	_	_	_
31	HLA	HLA	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
32	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
33	DRA	DRA	PROPN	NNP	Number=Sing	_	_	_	_
34	mRNA	mRNa	PROPN	NNP	Number=Sing	_	_	_	_
35	expression	expression	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
36	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 203
# text = Transient transfection of a B lymphoma line resulted in up to 89% reduction of constitutive MHC class II expression within 5 days and suppression of HLA-DRA mRNA synthesis.
1	Transient	Transient	ADJ	JJ	Degree=Pos	_	_	_	_
2	transfection	transfection	NOUN	NN	Number=Sing	_	_	_	_
3	of	of	ADP	IN	_	_	_	_	_
4	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
5	B	b	ADJ	JJ	Degree=Pos	_	_	_	_
6	lymphoma	lymphoma	NOUN	NN	Number=Sing	_	_	_	_
7	line	line	NOUN	NN	Number=Sing	_	_	_	_
8	resulted	result	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
9	in	in	ADV	RB	_	_	_	_	_
10	up	up	ADP	IN	_	_	_	_	_
11	to	to	ADP	IN	_	_	_	_	_
12	89	89	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
13	%	%	SYM	NN	Number=Sing	_	_	_	_
14	reduction	reduction	NOUN	NN	Number=Sing	_	_	_	_
15	of	of	ADP	IN	_	_	_	_	_
16	constitutive	constitutive	ADJ	JJ	Degree=Pos	_	_	_	_
17	MHC	MHC	PROPN	NNP	Number=Sing	_	_	_	_
18	class	class	NOUN	NN	Number=Sing	_	_	_	_
19	II	ii	NUM	CD	NumType=Card	_	_	_	_
20	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
21	within	within	ADP	IN	_	_	_	_	_
22	5	5	NUM	CD	NumType=Card	_	_	_	_
23	days	day	NOUN	NNS	Number=Plur	_	_	_	_
24	and	and	CCONJ	CC	_	_	_	_	_
25	suppression	suppression	NOUN	NN	Number=Sing	_	_	_	_
26	of	of	ADP	IN	_	_	_	_	_
27	HLA	HLA	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
28	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
29	DRA	DRA	PROPN	NNP	Number=Sing	_	_	_	_
30	mRNA	mRNA	PROPN	NNP	Number=Sing	_	_	_	_
31	synthesis	synthesis	PROPN	NNPS	Number=Plur	_	_	_	SpaceAfter=No
32	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 204
# text = Document 00300264 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	00300264	00300264	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 205
# text = Regulation of jun and fos gene expression in human monocytes by the macrophage colony-stimulating factor.
1	Regulation	regulation	NOUN	NN	Number=Sing	_	_	_	_
2	of	of	ADP	IN	_	_	_	_	_
3	jun	jun	NOUN	NN	Number=Sing	_	_	_	_
4	and	and	CCONJ	CC	_	_	_	_	_
5	fos	fo	NOUN	NNS	Number=Plur	_	_	_	_
6	gene	gene	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
7	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
8	in	in	ADP	IN	_	_	_	_	_
9	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
10	monocytes	monocyte	NOUN	NNS	Number=Plur	_	_	_	_
11	by	by	ADP	IN	_	_	_	_	_
12	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
13	macrophage	macrophage	NOUN	NN	Number=Sing	_	_	_	_
14	colony	colony	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
15	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
16	stimulating	stimulating	VERB	VBG	VerbForm=Ger	_	_	_	_
17	factor	factor	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
18	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 206
# text = The macrophage colony-stimulating factor (M-CSF) is required for the growth and differentiation of mononuclear phagocytes.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	macrophage	macrophage	NOUN	NN	Number=Sing	_	_	_	_
3	colony	colony	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
4	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
5	stimulating	stimulating	NOUN	NN	Number=Sing	_	_	_	_
6	factor	factor	NOUN	NN	Number=Sing	_	_	_	_
7	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
8	M	m	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
9	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
10	CSF	Csf	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
11	)	)	PUNCT	-RRB-	_	_	_	_	_
12	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
13	required	require	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
14	for	for	ADP	IN	_	_	_	_	_
15	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
16	growth	growth	NOUN	NN	Number=Sing	_	_	_	_
17	and	and	CCONJ	CC	_	_	_	_	_
18	differentiation	differentiation	NOUN	NN	Number=Sing	_	_	_	_
19	of	of	ADP	IN	_	_	_	_	_
20	mononuclear	mononuclear	ADJ	JJ	Degree=Pos	_	_	_	_
21	phagocytes	phagocyte	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
22	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 207
# text = However, the signaling events responsible for these effects remain unclear.
1	However	however	ADV	RB	_	_	_	_	SpaceAfter=No
2	,	,	PUNCT	,	_	_	_	_	_
3	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
4	signaling	signaling	VERB	VBG	VerbForm=Ger	_	_	_	_
5	events	event	NOUN	NNS	Number=Plur	_	_	_	_
6	responsible	responsible	ADJ	JJ	Degree=Pos	_	_	_	_
7	for	for	ADP	IN	_	_	_	_	_
8	these	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
9	effects	effect	NOUN	NNS	Number=Plur	_	_	_	_
10	remain	remain	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
11	unclear	unclear	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
12	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 208
# text = The present studies have examined the effects of M-CSF on potential signaling pathways involving expression of the jun and fos early response genes.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	present	present	ADJ	JJ	Degree=Pos	_	_	_	_
3	studies	study	NOUN	NNS	Number=Plur	_	_	_	_
4	have	have	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
5	examined	examine	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
6	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
7	effects	effect	NOUN	NNS	Number=Plur	_	_	_	_
8	of	of	ADP	IN	_	_	_	_	_
9	M-	M-	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
10	CSF	CSF	NOUN	NN	Number=Sing	_	_	_	_
11	on	on	ADP	IN	_	_	_	_	_
12	potential	potential	ADJ	JJ	Degree=Pos	_	_	_	_
13	signaling	signaling	NOUN	NN	Number=Sing	_	_	_	_
14	pathways	pathway	NOUN	NNS	Number=Plur	_	_	_	_
15	involving	involve	VERB	VBG	VerbForm=Ger	_	_	_	_
16	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
17	of	of	ADP	IN	_	_	_	_	_
18	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
19	jun	jun	NOUN	NN	Number=Sing	_	_	_	_
20	and	and	CCONJ	CC	_	_	_	_	_
21	fos	fo	NOUN	NNS	Number=Plur	_	_	_	_
22	early	early	ADJ	JJ	Degree=Pos	_	_	_	_
23	response	response	NOUN	NN	Number=Sing	_	_	_	_
24	genes	gene	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
25	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 209
# text = Low levels of c-jun transcripts were detectable in resting human peripheral blood monocytes.
1	Low	low	VERB	VB	Mood=Imp|VerbForm=Fin	_	_	_	_
2	levels	level	NOUN	NNS	Number=Plur	_	_	_	_
3	of	of	ADP	IN	_	_	_	_	_
4	c-	c-	SYM	NFP	_	_	_	_	SpaceAfter=No
5	jun	jun	ADJ	JJ	Degree=Pos	_	_	_	_
6	transcripts	transcript	NOUN	NNS	Number=Plur	_	_	_	_
7	were	be	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
8	detectable	detectable	ADJ	JJ	Degree=Pos	_	_	_	_
9	in	in	SCONJ	IN	_	_	_	_	_
10	resting	rest	VERB	VBG	VerbForm=Ger	_	_	_	_
11	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
12	peripheral	peripheral	ADJ	JJ	Degree=Pos	_	_	_	_
13	blood	blood	NOUN	NN	Number=Sing	_	_	_	_
14	monocytes	monocyte	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
15	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 210
# text = Treatment of these cells with 10(3) units/ml human recombinant M-CSF was associated with rapid and transient increases in c-jun mRNA levels.
1	Treatment	treatment	NOUN	NN	Number=Sing	_	_	_	_
2	of	of	ADP	IN	_	_	_	_	_
3	these	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
4	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
5	with	with	ADP	IN	_	_	_	_	_
6	10	10	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
7	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
8	3	3	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
9	)	)	PUNCT	-RRB-	_	_	_	_	_
10	units	unit	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
11	/	/	PUNCT	,	_	_	_	_	SpaceAfter=No
12	ml	ml	ADJ	JJ	Degree=Pos	_	_	_	_
13	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
14	recombinant	recombinant	NOUN	NN	Number=Sing	_	_	_	_
15	M-	M-	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
16	CSF	CSF	PROPN	NNP	Number=Sing	_	_	_	_
17	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
18	associated	associate	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
19	with	with	ADP	IN	_	_	_	_	_
20	rapid	rapid	ADJ	JJ	Degree=Pos	_	_	_	_
21	and	and	CCONJ	CC	_	_	_	_	_
22	transient	transient	ADJ	JJ	Degree=Pos	_	_	_	_
23	increases	increase	NOUN	NNS	Number=Plur	_	_	_	_
24	in	in	ADP	IN	_	_	_	_	_
25	c-	c-	SYM	NFP	_	_	_	_	SpaceAfter=No
26	jun	jun	NOUN	NN	Number=Sing	_	_	_	_
27	mRNA	mRNa	NOUN	NN	Number=Sing	_	_	_	_
28	levels	level	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
29	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 211
# text = Nuclear run-on assays and mRNA stability studies demonstrated that M-CSF regulates c-jun expression by both an increase in transcription rate and a prolongation in the half-life of c-jun transcripts.
1	Nuclear	nuclear	ADJ	JJ	Degree=Pos	_	_	_	_
2	run	run	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	SpaceAfter=No
3	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
4	on	on	ADP	IN	_	_	_	_	_
5	assays	assay	NOUN	NNS	Number=Plur	_	_	_	_
6	and	and	CCONJ	CC	_	_	_	_	_
7	mRNA	mRNA	NOUN	NN	Number=Sing	_	_	_	_
8	stability	stability	NOUN	NN	Number=Sing	_	_	_	_
9	studies	study	NOUN	NNS	Number=Plur	_	_	_	_
10	demonstrated	demonstrate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
11	that	that	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
12	M	m	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
13	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
14	CSF	Csf	NOUN	NN	Number=Sing	_	_	_	_
15	regulates	regulate	NOUN	NNS	Number=Plur	_	_	_	_
16	c-	c-	PUNCT	,	_	_	_	_	SpaceAfter=No
17	jun	jun	ADJ	JJ	Degree=Pos	_	_	_	_
18	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
19	by	by	ADP	IN	_	_	_	_	_
20	both	both	CCONJ	CC	_	_	_	_	_
21	an	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
22	increase	increase	NOUN	NN	Number=Sing	_	_	_	_
23	in	in	ADP	IN	_	_	_	_	_
24	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
25	rate	rate	NOUN	NN	Number=Sing	_	_	_	_
26	and	and	CCONJ	CC	_	_	_	_	_
27	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
28	prolongation	prolongation	NOUN	NN	Number=Sing	_	_	_	_
29	in	in	ADP	IN	_	_	_	_	_
30	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
31	half	half	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
32	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
33	life	life	NOUN	NN	Number=Sing	_	_	_	_
34	of	of	ADP	IN	_	_	_	_	_
35	c-	c-	SYM	NFP	_	_	_	_	SpaceAfter=No
36	jun	jun	ADJ	JJ	Degree=Pos	_	_	_	_
37	transcripts	transcript	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
38	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 212
# text = M-CSF treatment was also associated with a rapid induction of the jun-B gene, although expression of this gene was prolonged compared to that of c-jun.
1	M	m	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
2	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
3	CSF	Csf	NOUN	NN	Number=Sing	_	_	_	_
4	treatment	treatment	NOUN	NN	Number=Sing	_	_	_	_
5	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
6	also	also	ADV	RB	_	_	_	_	_
7	associated	associate	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
8	with	with	ADP	IN	_	_	_	_	_
9	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
10	rapid	rapid	ADJ	JJ	Degree=Pos	_	_	_	_
11	induction	induction	NOUN	NN	Number=Sing	_	_	_	_
12	of	of	ADP	IN	_	_	_	_	_
13	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
14	jun	jun	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
15	-B	-b	NOUN	NN	Number=Sing	_	_	_	_
16	gene	gene	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
17	,	,	PUNCT	,	_	_	_	_	_
18	although	although	SCONJ	IN	_	_	_	_	_
19	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
20	of	of	ADP	IN	_	_	_	_	_
21	this	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
22	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
23	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
24	prolonged	prolonge	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
25	compared	compare	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
26	to	to	ADP	IN	_	_	_	_	_
27	that	that	PRON	DT	Number=Sing|PronType=Dem	_	_	_	_
28	of	of	ADP	IN	_	_	_	_	_
29	c-	c-	SYM	NFP	_	_	_	_	SpaceAfter=No
30	jun	jun	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
31	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 213
# text = We further demonstrate that M-CSF increases c-fos mRNA levels in human monocytes through control at both the transcriptional and posttranscriptional levels.
1	We	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
2	further	further	ADV	RB	_	_	_	_	_
3	demonstrate	demonstrate	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
4	that	that	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
5	M	m	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
6	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
7	CSF	Csf	NOUN	NN	Number=Sing	_	_	_	_
8	increases	increase	NOUN	NNS	Number=Plur	_	_	_	_
9	c-	c-	PUNCT	,	_	_	_	_	SpaceAfter=No
10	fos	fo	NOUN	NNS	Number=Plur	_	_	_	_
11	mRNA	mRNa	ADP	IN	_	_	_	_	_
12	levels	level	NOUN	NNS	Number=Plur	_	_	_	_
13	in	in	ADP	IN	_	_	_	_	_
14	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
15	monocytes	monocyte	NOUN	NNS	Number=Plur	_	_	_	_
16	through	through	ADP	IN	_	_	_	_	_
17	control	control	NOUN	NN	Number=Sing	_	_	_	_
18	at	at	ADP	IN	_	_	_	_	_
19	both	both	CCONJ	CC	_	_	_	_	_
20	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
21	transcriptional	transcriptional	ADJ	JJ	Degree=Pos	_	_	_	_
22	and	and	CCONJ	CC	_	_	_	_	_
23	posttranscriptional	posttranscriptional	ADJ	JJ	Degree=Pos	_	_	_	_
24	levels	level	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
25	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 214
# text = Maximal induction of the c-fos gene was followed by that for the fos-B gene.
1	Maximal	Maximal	ADJ	JJ	Degree=Pos	_	_	_	_
2	induction	induction	NOUN	NN	Number=Sing	_	_	_	_
3	of	of	ADP	IN	_	_	_	_	_
4	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
5	c	c	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
6	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
7	fos	fos	NOUN	NNS	Number=Plur	_	_	_	_
8	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
9	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
10	followed	follow	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
11	by	by	ADP	IN	_	_	_	_	_
12	that	that	PRON	DT	Number=Sing|PronType=Dem	_	_	_	_
13	for	for	ADP	IN	_	_	_	_	_
14	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
15	fos	fo	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
16	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
17	B	b	ADJ	JJ	Degree=Pos	_	_	_	_
18	gene	gene	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
19	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 215
# text = Moreover, M-CSF-induced expression of the fos-related gene, fra-1, was delayed compared to that for both c-fos and fos-B.
1	Moreover	moreover	ADV	RB	_	_	_	_	SpaceAfter=No
2	,	,	PUNCT	,	_	_	_	_	_
3	M-	M-	SYM	NFP	_	_	_	_	SpaceAfter=No
4	CSF	CSF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
5	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
6	induced	induce	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
7	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
8	of	of	ADP	IN	_	_	_	_	_
9	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
10	fos	fo	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
11	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
12	related	related	ADJ	JJ	Degree=Pos	_	_	_	_
13	gene	gene	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
14	,	,	PUNCT	,	_	_	_	_	_
15	fra	fra	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
16	-1	-1	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
17	,	,	PUNCT	,	_	_	_	_	_
18	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
19	delayed	delay	ADJ	JJ	Degree=Pos	_	_	_	_
20	compared	compare	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
21	to	to	ADP	IN	_	_	_	_	_
22	that	that	PRON	DT	Number=Sing|PronType=Dem	_	_	_	_
23	for	for	ADP	IN	_	_	_	_	_
24	both	both	DET	DT	_	_	_	_	_
25	c-	c-	SYM	SYM	_	_	_	_	SpaceAfter=No
26	fos	fo	NOUN	NNS	Number=Plur	_	_	_	_
27	and	and	CCONJ	CC	_	_	_	_	_
28	fos	fo	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
29	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
30	B	b	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
31	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 216
# text = Taken together, the results indicate that M-CSF treatment is associated with differential activation of multiple members of the jun/fos family and that expression of these genes could contribute to nuclear signaling mechanisms that regulate a specific program of monocyte differentiation.
1	Taken	take	PROPN	NNP	Number=Sing	_	_	_	_
2	together	together	ADV	RB	_	_	_	_	SpaceAfter=No
3	,	,	PUNCT	,	_	_	_	_	_
4	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
5	results	result	NOUN	NNS	Number=Plur	_	_	_	_
6	indicate	indicate	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
7	that	that	SCONJ	IN	_	_	_	_	_
8	M	m	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
9	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
10	CSF	Csf	NOUN	NN	Number=Sing	_	_	_	_
11	treatment	treatment	NOUN	NN	Number=Sing	_	_	_	_
12	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
13	associated	associate	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
14	with	with	ADP	IN	_	_	_	_	_
15	differential	differential	NOUN	NN	Number=Sing	_	_	_	_
16	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
17	of	of	ADP	IN	_	_	_	_	_
18	multiple	multiple	ADJ	JJ	Degree=Pos	_	_	_	_
19	members	member	NOUN	NNS	Number=Plur	_	_	_	_
20	of	of	ADP	IN	_	_	_	_	_
21	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
22	jun	jun	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
23	/	/	PUNCT	,	_	_	_	_	SpaceAfter=No
24	fos	fos	NOUN	NN	Number=Sing	_	_	_	_
25	family	family	NOUN	NN	Number=Sing	_	_	_	_
26	and	and	CCONJ	CC	_	_	_	_	_
27	that	that	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
28	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
29	of	of	ADP	IN	_	_	_	_	_
30	these	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
31	genes	gene	NOUN	NNS	Number=Plur	_	_	_	_
32	could	could	AUX	MD	VerbForm=Fin	_	_	_	_
33	contribute	contribute	VERB	VB	VerbForm=Inf	_	_	_	_
34	to	to	PART	TO	_	_	_	_	_
35	nuclear	nuclear	VERB	VB	VerbForm=Inf	_	_	_	_
36	signaling	signal	VERB	VBG	VerbForm=Ger	_	_	_	_
37	mechanisms	mechanism	NOUN	NNS	Number=Plur	_	_	_	_
38	that	that	PRON	WDT	PronType=Rel	_	_	_	_
39	regulate	regulate	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
40	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
41	specific	specific	ADJ	JJ	Degree=Pos	_	_	_	_
42	program	program	NOUN	NN	Number=Sing	_	_	_	_
43	of	of	ADP	IN	_	_	_	_	_
44	monocyte	monocyte	NOUN	NN	Number=Sing	_	_	_	_
45	differentiation	differentiation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
46	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 217
# text = Document 00300280 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	00300280	00300280	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 218
# text = Uncoupling activation-dependent HS1 phosphorylation from nuclear factor of activated T cells transcriptional activation in Jurkat T cells: differential signaling through CD3 and the costimulatory receptors CD2 and CD28. CD3, CD2, and CD28 are functionally distinct receptors on T lymphocytes.
1	Uncoupling	Uncoupl	VERB	VBG	VerbForm=Ger	_	_	_	_
2	activation	activation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
3	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
4	dependent	dependent	ADJ	JJ	Degree=Pos	_	_	_	_
5	HS1	Hs1	NOUN	NN	Number=Sing	_	_	_	_
6	phosphorylation	phosphorylation	NOUN	NN	Number=Sing	_	_	_	_
7	from	from	ADP	IN	_	_	_	_	_
8	nuclear	nuclear	ADJ	JJ	Degree=Pos	_	_	_	_
9	factor	factor	NOUN	NN	Number=Sing	_	_	_	_
10	of	of	ADP	IN	_	_	_	_	_
11	activated	activate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
12	T	t	PROPN	NNP	Number=Sing	_	_	_	_
13	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
14	transcriptional	transcriptional	ADJ	JJ	Degree=Pos	_	_	_	_
15	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
16	in	in	ADP	IN	_	_	_	_	_
17	Jurkat	Jurkat	PROPN	NNP	Number=Sing	_	_	_	_
18	T	T	PROPN	NNP	Number=Sing	_	_	_	_
19	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
20	:	:	PUNCT	:	_	_	_	_	_
21	differential	differential	ADJ	JJ	Degree=Pos	_	_	_	_
22	signaling	signaling	NOUN	NN	Number=Sing	_	_	_	_
23	through	through	ADP	IN	_	_	_	_	_
24	CD3	CD3	NOUN	NN	Number=Sing	_	_	_	_
25	and	and	CCONJ	CC	_	_	_	_	_
26	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
27	costimulatory	costimulatory	ADJ	JJ	Degree=Pos	_	_	_	_
28	receptors	receptor	NOUN	NNS	Number=Plur	_	_	_	_
29	CD2	Cd2	NOUN	NN	Number=Sing	_	_	_	_
30	and	and	CCONJ	CC	_	_	_	_	_
31	CD28.	CD28.	NOUN	NN	Number=Sing	_	_	_	SpacesAfter=\s\n
32	CD3	CD3	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
33	,	,	PUNCT	,	_	_	_	_	_
34	CD2	Cd2	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
35	,	,	PUNCT	,	_	_	_	_	_
36	and	and	CCONJ	CC	_	_	_	_	_
37	CD28	CD28	PROPN	NNP	Number=Sing	_	_	_	_
38	are	be	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
39	functionally	functionally	ADV	RB	_	_	_	_	_
40	distinct	distinct	ADJ	JJ	Degree=Pos	_	_	_	_
41	receptors	receptor	NOUN	NNS	Number=Plur	_	_	_	_
42	on	on	ADP	IN	_	_	_	_	_
43	T	t	PROPN	NNP	Number=Sing	_	_	_	_
44	lymphocytes	lymphocyte	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
45	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 219
# text = Engagement of any of these receptors induces the rapid tyrosine phosphorylation of a shared group of intracellular signaling proteins, including Vav, Cbl, p85 phosphoinositide 3-kinase, and the Src family kinases Lck and Fyn.
1	Engagement	engagement	NOUN	NN	Number=Sing	_	_	_	_
2	of	of	ADP	IN	_	_	_	_	_
3	any	any	DET	DT	_	_	_	_	_
4	of	of	ADP	IN	_	_	_	_	_
5	these	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
6	receptors	receptor	NOUN	NNS	Number=Plur	_	_	_	_
7	induces	induce	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
8	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
9	rapid	rapid	ADJ	JJ	Degree=Pos	_	_	_	_
10	tyrosine	tyrosine	NOUN	NN	Number=Sing	_	_	_	_
11	phosphorylation	phosphorylation	NOUN	NN	Number=Sing	_	_	_	_
12	of	of	ADP	IN	_	_	_	_	_
13	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
14	shared	share	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
15	group	group	NOUN	NN	Number=Sing	_	_	_	_
16	of	of	ADP	IN	_	_	_	_	_
17	intracellular	intracellular	ADJ	JJ	Degree=Pos	_	_	_	_
18	signaling	signaling	NOUN	NN	Number=Sing	_	_	_	_
19	proteins	protein	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
20	,	,	PUNCT	,	_	_	_	_	_
21	including	include	VERB	VBG	VerbForm=Ger	_	_	_	_
22	Vav	Vav	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
23	,	,	PUNCT	,	_	_	_	_	_
24	Cbl	Cbl	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
25	,	,	PUNCT	,	_	_	_	_	_
26	p85	p85	NUM	CD	NumType=Card	_	_	_	_
27	phosphoinositide	phosphoinositide	NOUN	NN	Number=Sing	_	_	_	_
28	3	3	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
29	-	-	PUNCT	:	_	_	_	_	SpaceAfter=No
30	kinase	kinase	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
31	,	,	PUNCT	,	_	_	_	_	_
32	and	and	CCONJ	CC	_	_	_	_	_
33	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
34	Src	Src	ADJ	JJ	Degree=Pos	_	_	_	_
35	family	family	NOUN	NN	Number=Sing	_	_	_	_
36	kinases	kinase	NOUN	NNS	Number=Plur	_	_	_	_
37	Lck	Lck	PROPN	NNP	Number=Sing	_	_	_	_
38	and	and	CCONJ	CC	_	_	_	_	_
39	Fyn	Fyn	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
40	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 220
# text = Ligation of CD3 also induces the tyrosine phosphorylation of HS1, a 75-kDa hematopoietic cell-specific intracellular signaling protein of unknown function.
1	Ligation	Ligation	NOUN	NN	Number=Sing	_	_	_	_
2	of	of	ADP	IN	_	_	_	_	_
3	CD3	CD3	NOUN	NN	Number=Sing	_	_	_	_
4	also	also	ADV	RB	_	_	_	_	_
5	induces	induce	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
6	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
7	tyrosine	tyrosine	NOUN	NN	Number=Sing	_	_	_	_
8	phosphorylation	phosphorylation	NOUN	NN	Number=Sing	_	_	_	_
9	of	of	ADP	IN	_	_	_	_	_
10	HS1	HS1	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
11	,	,	PUNCT	,	_	_	_	_	_
12	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
13	75	75	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
14	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
15	kDa	kDa	NOUN	NN	Number=Sing	_	_	_	_
16	hematopoietic	hematopoietic	ADJ	JJ	Degree=Pos	_	_	_	_
17	cell	cell	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
18	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
19	specific	specific	ADJ	JJ	Degree=Pos	_	_	_	_
20	intracellular	intracelular	ADJ	JJ	Degree=Pos	_	_	_	_
21	signaling	signale	NOUN	NN	Number=Sing	_	_	_	_
22	protein	protein	NOUN	NN	Number=Sing	_	_	_	_
23	of	of	ADP	IN	_	_	_	_	_
24	unknown	unknown	ADJ	JJ	Degree=Pos	_	_	_	_
25	function	function	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
26	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 221
# text = We have examined changes in HS1 phosphorylation after differential stimulation of CD3, CD2, and CD28 to elucidate its role in T cells and to further delineate the signaling pathways recruited by these receptors.
1	We	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
2	have	have	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
3	examined	examine	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
4	changes	change	NOUN	NNS	Number=Plur	_	_	_	_
5	in	in	ADP	IN	_	_	_	_	_
6	HS1	HS1	NUM	CD	NumType=Card	_	_	_	_
7	phosphorylation	phosphorylation	NOUN	NN	Number=Sing	_	_	_	_
8	after	after	ADP	IN	_	_	_	_	_
9	differential	differential	ADJ	JJ	Degree=Pos	_	_	_	_
10	stimulation	stimulation	NOUN	NN	Number=Sing	_	_	_	_
11	of	of	ADP	IN	_	_	_	_	_
12	CD3	CD3	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
13	,	,	PUNCT	,	_	_	_	_	_
14	CD2	Cd2	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
15	,	,	PUNCT	,	_	_	_	_	_
16	and	and	CCONJ	CC	_	_	_	_	_
17	CD28	CD28	PROPN	NNP	Number=Sing	_	_	_	_
18	to	to	PART	TO	_	_	_	_	_
19	elucidate	elucidate	VERB	VB	VerbForm=Inf	_	_	_	_
20	its	its	PRON	PRP$	Gender=Neut|Number=Sing|Person=3|Poss=Yes|PronType=Prs	_	_	_	_
21	role	role	NOUN	NN	Number=Sing	_	_	_	_
22	in	in	ADP	IN	_	_	_	_	_
23	T	t	PROPN	NNP	Number=Sing	_	_	_	_
24	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
25	and	and	CCONJ	CC	_	_	_	_	_
26	to	to	PART	TO	_	_	_	_	_
27	further	further	ADV	RB	_	_	_	_	_
28	delineate	delineate	VERB	VB	VerbForm=Inf	_	_	_	_
29	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
30	signaling	signal	NOUN	NN	Number=Sing	_	_	_	_
31	pathways	pathway	NOUN	NNS	Number=Plur	_	_	_	_
32	recruited	recruit	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
33	by	by	ADP	IN	_	_	_	_	_
34	these	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
35	receptors	receptor	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
36	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 222
# text = Unlike ligation of CD3, stimulation with anti-CD28 mAb or CHO cells expressing the CD28 ligands CD80 or CD86 did not lead to tyrosine phosphorylation of HS1 in Jurkat T cells.
1	Unlike	unlike	ADP	IN	_	_	_	_	_
2	ligation	ligation	NOUN	NN	Number=Sing	_	_	_	_
3	of	of	ADP	IN	_	_	_	_	_
4	CD3	CD3	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
5	,	,	PUNCT	,	_	_	_	_	_
6	stimulation	stimulation	NOUN	NN	Number=Sing	_	_	_	_
7	with	with	ADP	IN	_	_	_	_	_
8	anti-CD28	anti-CD28	NUM	CD	NumType=Card	_	_	_	_
9	mAb	mAb	NOUN	NN	Number=Sing	_	_	_	_
10	or	or	CCONJ	CC	_	_	_	_	_
11	CHO	Cho	NOUN	NN	Number=Sing	_	_	_	_
12	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
13	expressing	express	VERB	VBG	VerbForm=Ger	_	_	_	_
14	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
15	CD28	CD28	PROPN	NNP	Number=Sing	_	_	_	_
16	ligands	ligand	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
17	CD80	CD80	PROPN	NNP	Number=Sing	_	_	_	_
18	or	or	CCONJ	CC	_	_	_	_	_
19	CD86	CD86	PROPN	NNP	Number=Sing	_	_	_	_
20	did	do	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
21	not	not	PART	RB	_	_	_	_	_
22	lead	lead	VERB	VB	VerbForm=Inf	_	_	_	_
23	to	to	PART	TO	_	_	_	_	_
24	tyrosine	tyrosine	VERB	VB	VerbForm=Inf	_	_	_	_
25	phosphorylation	phosphorylation	NOUN	NN	Number=Sing	_	_	_	_
26	of	of	ADP	IN	_	_	_	_	_
27	HS1	HS1	PROPN	NNP	Number=Sing	_	_	_	_
28	in	in	ADP	IN	_	_	_	_	_
29	Jurkat	Jurkat	PROPN	NNP	Number=Sing	_	_	_	_
30	T	T	PROPN	NNP	Number=Sing	_	_	_	_
31	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
32	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 223
# text = Additionally, no tyrosine phosphorylation of HS1 was induced by mitogenic pairs of anti-CD2 mAbs capable of activating the transcription factor NFAT (nuclear factor of activated T cells).
1	Additionally	additionally	ADV	RB	_	_	_	_	SpaceAfter=No
2	,	,	PUNCT	,	_	_	_	_	_
3	no	no	DET	DT	_	_	_	_	_
4	tyrosine	tyrosine	NOUN	NN	Number=Sing	_	_	_	_
5	phosphorylation	phosphorylation	NOUN	NN	Number=Sing	_	_	_	_
6	of	of	ADP	IN	_	_	_	_	_
7	HS1	Hs1	PROPN	NNP	Number=Sing	_	_	_	_
8	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
9	induced	induce	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
10	by	by	ADP	IN	_	_	_	_	_
11	mitogenic	mitogenic	ADJ	JJ	Degree=Pos	_	_	_	_
12	pairs	pair	NOUN	NNS	Number=Plur	_	_	_	_
13	of	of	ADP	IN	_	_	_	_	_
14	anti-CD2	anti-CD2	NUM	CD	NumType=Card	_	_	_	_
15	mAbs	mAb	NOUN	NNS	Number=Plur	_	_	_	_
16	capable	capable	ADJ	JJ	Degree=Pos	_	_	_	_
17	of	of	SCONJ	IN	_	_	_	_	_
18	activating	activat	VERB	VBG	VerbForm=Ger	_	_	_	_
19	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
20	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
21	factor	factor	NOUN	NN	Number=Sing	_	_	_	_
22	NFAT	NFAT	PROPN	NNP	Number=Sing	_	_	_	_
23	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
24	nuclear	nuclear	ADJ	JJ	Degree=Pos	_	_	_	_
25	factor	factor	NOUN	NN	Number=Sing	_	_	_	_
26	of	of	ADP	IN	_	_	_	_	_
27	activated	activate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
28	T	t	PROPN	NNP	Number=Sing	_	_	_	_
29	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
30	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
31	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 224
# text = Costimulation through CD28 and/or CD2 did not modulate the CD3-dependent phosphorylation of HS1.
1	Costimulation	Costimulation	NOUN	NN	Number=Sing	_	_	_	_
2	through	through	ADP	IN	_	_	_	_	_
3	CD28	CD28	NOUN	NN	Number=Sing	_	_	_	_
4	and	and	CCONJ	CC	_	_	_	_	SpaceAfter=No
5	/	/	PUNCT	,	_	_	_	_	SpaceAfter=No
6	or	or	CCONJ	CC	_	_	_	_	_
7	CD2	CD2	NUM	CD	NumType=Card	_	_	_	_
8	did	do	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
9	not	not	PART	RB	_	_	_	_	_
10	modulate	modulate	VERB	VB	VerbForm=Inf	_	_	_	_
11	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
12	CD3	CD3	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
13	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
14	dependent	dependent	ADJ	JJ	Degree=Pos	_	_	_	_
15	phosphorylation	phosphorylation	NOUN	NN	Number=Sing	_	_	_	_
16	of	of	ADP	IN	_	_	_	_	_
17	HS1	HS1	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
18	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 225
# text = In vivo studies indicated that CD3-induced HSI phosphorylation was dependent upon both the Src family tyrosine kinase Lck and the tyrosine phosphatase CD45, did not require MEK1 kinase activity, and was regulated by protein kinase C activation.
1	In	in	ADP	IN	_	_	_	_	_
2	vivo	vivo	ADJ	JJ	Degree=Pos	_	_	_	_
3	studies	study	NOUN	NNS	Number=Plur	_	_	_	_
4	indicated	indicate	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
5	that	that	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
6	CD3	CD3	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
7	-induced	-induce	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
8	HSI	HSI	NUM	CD	NumType=Card	_	_	_	_
9	phosphorylation	phosphorylation	NOUN	NN	Number=Sing	_	_	_	_
10	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
11	dependent	dependent	ADJ	JJ	Degree=Pos	_	_	_	_
12	upon	upon	ADP	IN	_	_	_	_	_
13	both	both	CCONJ	CC	_	_	_	_	_
14	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
15	Src	Src	ADJ	JJ	Degree=Pos	_	_	_	_
16	family	family	NOUN	NN	Number=Sing	_	_	_	_
17	tyrosine	tyrosine	NOUN	NN	Number=Sing	_	_	_	_
18	kinase	kinase	NOUN	NN	Number=Sing	_	_	_	_
19	Lck	Lck	NOUN	NN	Number=Sing	_	_	_	_
20	and	and	CCONJ	CC	_	_	_	_	_
21	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
22	tyrosine	tyrosine	NOUN	NN	Number=Sing	_	_	_	_
23	phosphatase	phosphatase	NOUN	NN	Number=Sing	_	_	_	_
24	CD45	CD45	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
25	,	,	PUNCT	,	_	_	_	_	_
26	did	do	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
27	not	not	PART	RB	_	_	_	_	_
28	require	require	VERB	VB	VerbForm=Inf	_	_	_	_
29	MEK1	MEK1	NUM	CD	NumType=Card	_	_	_	_
30	kinase	kinase	NOUN	NN	Number=Sing	_	_	_	_
31	activity	activity	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
32	,	,	PUNCT	,	_	_	_	_	_
33	and	and	CCONJ	CC	_	_	_	_	_
34	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
35	regulated	regulate	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
36	by	by	ADP	IN	_	_	_	_	_
37	protein	protein	NOUN	NN	Number=Sing	_	_	_	_
38	kinase	kinase	NOUN	NN	Number=Sing	_	_	_	_
39	C	c	NOUN	NN	Number=Sing	_	_	_	_
40	activation	activation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
41	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 226
# text = Thus, although CD3, CD28, and CD2 activate many of the same signaling molecules, they differed in their capacity to induce the tyrosine phosphorylation of HSI.
1	Thus	thus	ADV	RB	_	_	_	_	SpaceAfter=No
2	,	,	PUNCT	,	_	_	_	_	_
3	although	although	SCONJ	IN	_	_	_	_	_
4	CD3	CD3	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
5	,	,	PUNCT	,	_	_	_	_	_
6	CD28	CD28	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
7	,	,	PUNCT	,	_	_	_	_	_
8	and	and	CCONJ	CC	_	_	_	_	_
9	CD2	CD2	NUM	CD	NumType=Card	_	_	_	_
10	activate	activate	NOUN	NN	Number=Sing	_	_	_	_
11	many	many	ADJ	JJ	Degree=Pos	_	_	_	_
12	of	of	ADP	IN	_	_	_	_	_
13	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
14	same	same	ADJ	JJ	Degree=Pos	_	_	_	_
15	signaling	signaling	NOUN	NN	Number=Sing	_	_	_	_
16	molecules	molecule	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
17	,	,	PUNCT	,	_	_	_	_	_
18	they	they	PRON	PRP	Case=Nom|Number=Plur|Person=3|PronType=Prs	_	_	_	_
19	differed	differ	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
20	in	in	ADP	IN	_	_	_	_	_
21	their	they	PRON	PRP$	Number=Plur|Person=3|Poss=Yes|PronType=Prs	_	_	_	_
22	capacity	capacity	NOUN	NN	Number=Sing	_	_	_	_
23	to	to	PART	TO	_	_	_	_	_
24	induce	induce	VERB	VB	VerbForm=Inf	_	_	_	_
25	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
26	tyrosine	tyrosine	NOUN	NN	Number=Sing	_	_	_	_
27	phosphorylation	phosphorylation	NOUN	NN	Number=Sing	_	_	_	_
28	of	of	ADP	IN	_	_	_	_	_
29	HSI	HSI	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
30	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 227
# text = Furthermore, activation-dependent tyrosine phosphorylation of HS1 was not required for NFAT transcriptional activation.
1	Furthermore	furthermore	ADV	RB	_	_	_	_	SpaceAfter=No
2	,	,	PUNCT	,	_	_	_	_	_
3	activation	activation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
4	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
5	dependent	dependent	ADJ	JJ	Degree=Pos	_	_	_	_
6	tyrosine	tyrosine	NOUN	NN	Number=Sing	_	_	_	_
7	phosphorylation	phosphorylation	NOUN	NN	Number=Sing	_	_	_	_
8	of	of	ADP	IN	_	_	_	_	_
9	HS1	Hs1	PROPN	NNP	Number=Sing	_	_	_	_
10	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
11	not	not	PART	RB	_	_	_	_	_
12	required	require	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
13	for	for	ADP	IN	_	_	_	_	_
14	NFAT	Nfat	PROPN	NNP	Number=Sing	_	_	_	_
15	transcriptional	transcriptional	ADJ	JJ	Degree=Pos	_	_	_	_
16	activation	activation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
17	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 228
# text = Document 00300283 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	00300283	00300283	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 229
# text = Cytokine rescue from glucocorticoid induced apoptosis in T cells is mediated through inhibition of IkappaBalpha.
1	Cytokine	Cytokine	NOUN	NN	Number=Sing	_	_	_	_
2	rescue	rescue	NOUN	NN	Number=Sing	_	_	_	_
3	from	from	ADP	IN	_	_	_	_	_
4	glucocorticoid	glucocorticoid	ADJ	JJ	Degree=Pos	_	_	_	_
5	induced	induce	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
6	apoptosis	apoptosis	NOUN	NN	Number=Sing	_	_	_	_
7	in	in	ADP	IN	_	_	_	_	_
8	T	t	PROPN	NNP	Number=Sing	_	_	_	_
9	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
10	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
11	mediated	mediate	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
12	through	through	ADP	IN	_	_	_	_	_
13	inhibition	inhibition	NOUN	NN	Number=Sing	_	_	_	_
14	of	of	ADP	IN	_	_	_	_	_
15	IkappaBalpha	IkappaBalpha	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
16	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 230
# text = We previously reported that dexamethasone (DEX), a synthetic glucocorticoid, causes apoptosis in mature
1	We	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
2	previously	previously	ADV	RB	_	_	_	_	_
3	reported	report	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
4	that	that	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
5	dexamethasone	dexamethasone	NOUN	NN	Number=Sing	_	_	_	_
6	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
7	DEX	DEX	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
8	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
9	,	,	PUNCT	,	_	_	_	_	_
10	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
11	synthetic	synthetic	ADJ	JJ	Degree=Pos	_	_	_	_
12	glucocorticoid	glucocorticoid	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
13	,	,	PUNCT	,	_	_	_	_	_
14	causes	cause	NOUN	NNS	Number=Plur	_	_	_	_
15	apoptosis	apoptosis	NOUN	NN	Number=Sing	_	_	_	_
16	in	in	ADP	IN	_	_	_	_	_
17	mature	mature	ADJ	JJ	Degree=Pos	_	_	_	_

# sent_id = 231
# text = Th cell lines, and that this induction of cell death is prevented by specific cytokines, namely, by IL-2 in Th1 cells and by IL-4 in Th2 cells.
1	Th	th	ADJ	JJ	Degree=Pos|NumType=Ord	_	_	_	_
2	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
3	lines	line	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	,	,	PUNCT	,	_	_	_	_	_
5	and	and	CCONJ	CC	_	_	_	_	_
6	that	that	SCONJ	IN	_	_	_	_	_
7	this	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
8	induction	induction	NOUN	NN	Number=Sing	_	_	_	_
9	of	of	ADP	IN	_	_	_	_	_
10	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
11	death	death	NOUN	NN	Number=Sing	_	_	_	_
12	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
13	prevented	prevent	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
14	by	by	ADP	IN	_	_	_	_	_
15	specific	specific	ADJ	JJ	Degree=Pos	_	_	_	_
16	cytokines	cytokine	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
17	,	,	PUNCT	,	_	_	_	_	_
18	namely	namely	ADV	RB	_	_	_	_	SpaceAfter=No
19	,	,	PUNCT	,	_	_	_	_	_
20	by	by	ADP	IN	_	_	_	_	_
21	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
22	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
23	2	2	NUM	CD	NumType=Card	_	_	_	_
24	in	in	ADP	IN	_	_	_	_	_
25	Th1	Th1	NUM	CD	NumType=Card	_	_	_	_
26	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
27	and	and	CCONJ	CC	_	_	_	_	_
28	by	by	ADP	IN	_	_	_	_	_
29	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
30	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
31	4	4	NUM	CD	NumType=Card	_	_	_	_
32	in	in	ADP	IN	_	_	_	_	_
33	Th2	Th2	NUM	CD	NumType=Card	_	_	_	_
34	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
35	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 232
# text = We now show that this differential rescue by specific cytokines in Th cells correlates with the level of IkappaBalpha that is regulated by DEX and cytokines.
1	We	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
2	now	now	ADV	RB	_	_	_	_	_
3	show	show	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
4	that	that	SCONJ	IN	_	_	_	_	_
5	this	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
6	differential	differential	NOUN	NN	Number=Sing	_	_	_	_
7	rescue	rescue	NOUN	NN	Number=Sing	_	_	_	_
8	by	by	ADP	IN	_	_	_	_	_
9	specific	specific	ADJ	JJ	Degree=Pos	_	_	_	_
10	cytokines	cytokine	NOUN	NNS	Number=Plur	_	_	_	_
11	in	in	ADP	IN	_	_	_	_	_
12	Th	th	ADJ	JJ	Degree=Pos	_	_	_	_
13	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
14	correlates	correlate	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
15	with	with	ADP	IN	_	_	_	_	_
16	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
17	level	level	NOUN	NN	Number=Sing	_	_	_	_
18	of	of	ADP	IN	_	_	_	_	_
19	IkappaBalpha	IkappaBalpha	PROPN	NNP	Number=Sing	_	_	_	_
20	that	that	PRON	WDT	PronType=Rel	_	_	_	_
21	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
22	regulated	regulate	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
23	by	by	ADP	IN	_	_	_	_	_
24	DEX	Dex	PROPN	NNP	Number=Sing	_	_	_	_
25	and	and	CCONJ	CC	_	_	_	_	_
26	cytokines	cytokine	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
27	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 233
# text = In both cell types the cellular levels of IkappaBalpha mRNA and protein were evaluated by DEX treatment.
1	In	in	ADP	IN	_	_	_	_	_
2	both	both	DET	DT	_	_	_	_	_
3	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
4	types	type	NOUN	NNS	Number=Plur	_	_	_	_
5	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
6	cellular	cellular	ADJ	JJ	Degree=Pos	_	_	_	_
7	levels	level	NOUN	NNS	Number=Plur	_	_	_	_
8	of	of	ADP	IN	_	_	_	_	_
9	IkappaBalpha	IkappaBalpha	PROPN	NNP	Number=Sing	_	_	_	_
10	mRNA	mRNA	PROPN	NNP	Number=Sing	_	_	_	_
11	and	and	CCONJ	CC	_	_	_	_	_
12	protein	protein	NOUN	NN	Number=Sing	_	_	_	_
13	were	be	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
14	evaluated	evaluate	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
15	by	by	ADP	IN	_	_	_	_	_
16	DEX	Dex	PROPN	NNP	Number=Sing	_	_	_	_
17	treatment	treatment	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
18	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 234
# text = Interestingly, the DEX-mediated IkappaBalpha induction was completely inhibited by IL-2, but not IL-4, in Th1 cells, while the reverse profile was seen in Th2 cells.
1	Interestingly	Interestingly	ADV	RB	_	_	_	_	SpaceAfter=No
2	,	,	PUNCT	,	_	_	_	_	_
3	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
4	DEX	DEX	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
5	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
6	mediated	mediate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
7	IkappaBalpha	IkappaBalpha	PROPN	NNP	Number=Sing	_	_	_	_
8	induction	induction	NOUN	NN	Number=Sing	_	_	_	_
9	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
10	completely	completely	ADV	RB	_	_	_	_	_
11	inhibited	inhibit	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
12	by	by	ADP	IN	_	_	_	_	_
13	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
14	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
15	2	2	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
16	,	,	PUNCT	,	_	_	_	_	_
17	but	but	CCONJ	CC	_	_	_	_	_
18	not	not	ADV	RB	_	_	_	_	_
19	IL	Il	ADV	RB	_	_	_	_	SpaceAfter=No
20	-	-	SYM	SYM	_	_	_	_	SpaceAfter=No
21	4	4	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
22	,	,	PUNCT	,	_	_	_	_	_
23	in	in	ADP	IN	_	_	_	_	_
24	Th1	Th1	NUM	CD	NumType=Card	_	_	_	_
25	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
26	,	,	PUNCT	,	_	_	_	_	_
27	while	while	SCONJ	IN	_	_	_	_	_
28	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
29	reverse	reverse	NOUN	NN	Number=Sing	_	_	_	_
30	profile	profile	NOUN	NN	Number=Sing	_	_	_	_
31	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
32	seen	see	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
33	in	in	ADP	IN	_	_	_	_	_
34	Th2	Th2	NUM	CD	NumType=Card	_	_	_	_
35	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
36	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 235
# text = In both cell types, the cytokine that inhibits the induction of IkappaBalpha by DEX, also rescues these cells from DEX-induced apoptosis, although the rescue cytokine is different in Th1 and Th2 cells.
1	In	in	ADP	IN	_	_	_	_	_
2	both	both	DET	DT	_	_	_	_	_
3	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
4	types	type	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
5	,	,	PUNCT	,	_	_	_	_	_
6	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
7	cytokine	cytokine	NOUN	NN	Number=Sing	_	_	_	_
8	that	that	PRON	WDT	PronType=Rel	_	_	_	_
9	inhibits	inhibit	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
10	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
11	induction	induction	NOUN	NN	Number=Sing	_	_	_	_
12	of	of	ADP	IN	_	_	_	_	_
13	IkappaBalpha	IkappaBalpha	PROPN	NNP	Number=Sing	_	_	_	_
14	by	by	ADP	IN	_	_	_	_	_
15	DEX	DEX	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
16	,	,	PUNCT	,	_	_	_	_	_
17	also	also	ADV	RB	_	_	_	_	_
18	rescues	rescue	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
19	these	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
20	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
21	from	from	ADP	IN	_	_	_	_	_
22	DEX	DEX	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
23	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
24	induced	induce	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
25	apoptosis	apoptosis	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
26	,	,	PUNCT	,	_	_	_	_	_
27	although	although	SCONJ	IN	_	_	_	_	_
28	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
29	rescue	rescue	NOUN	NN	Number=Sing	_	_	_	_
30	cytokine	cytokine	NOUN	NN	Number=Sing	_	_	_	_
31	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
32	different	different	ADJ	JJ	Degree=Pos	_	_	_	_
33	in	in	ADP	IN	_	_	_	_	_
34	Th1	Th1	NUM	CD	NumType=Card	_	_	_	_
35	and	and	CCONJ	CC	_	_	_	_	_
36	Th2	Th2	NUM	CD	NumType=Card	_	_	_	_
37	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
38	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 236
# text = Our results imply that T cells need to maintain a certain level of NF-kappaB transcriptional activity in order to survive; up- or down-regulation of nuclear NF kappaB through modulation of IkappaBalpha expression by cytokines or DEX may lead to cell survival or cell death, respectively.
1	Our	we	PRON	PRP$	Number=Plur|Person=1|Poss=Yes|PronType=Prs	_	_	_	_
2	results	result	NOUN	NNS	Number=Plur	_	_	_	_
3	imply	imply	ADV	RB	_	_	_	_	_
4	that	that	SCONJ	IN	_	_	_	_	_
5	T	t	PROPN	NNP	Number=Sing	_	_	_	_
6	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
7	need	need	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
8	to	to	PART	TO	_	_	_	_	_
9	maintain	maintain	VERB	VB	VerbForm=Inf	_	_	_	_
10	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
11	certain	certain	ADJ	JJ	Degree=Pos	_	_	_	_
12	level	level	NOUN	NN	Number=Sing	_	_	_	_
13	of	of	ADP	IN	_	_	_	_	_
14	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
15	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
16	kappaB	kappaB	PROPN	NNP	Number=Sing	_	_	_	_
17	transcriptional	transcriptional	ADJ	JJ	Degree=Pos	_	_	_	_
18	activity	activity	NOUN	NN	Number=Sing	_	_	_	_
19	in	in	ADP	IN	_	_	_	_	_
20	order	order	NOUN	NN	Number=Sing	_	_	_	_
21	to	to	PART	TO	_	_	_	_	_
22	survive	survive	VERB	VB	VerbForm=Inf	_	_	_	SpaceAfter=No
23	;	;	PUNCT	,	_	_	_	_	_
24	up	up	ADP	IN	_	_	_	_	SpaceAfter=No
25	-	-	PUNCT	HYPH	_	_	_	_	_
26	or	or	CCONJ	CC	_	_	_	_	_
27	down	down	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
28	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
29	regulation	regulation	NOUN	NN	Number=Sing	_	_	_	_
30	of	of	ADP	IN	_	_	_	_	_
31	nuclear	nuclear	ADJ	JJ	Degree=Pos	_	_	_	_
32	NF	NF	PROPN	NNP	Number=Sing	_	_	_	_
33	kappaB	kappaB	PROPN	NNP	Number=Sing	_	_	_	_
34	through	through	ADP	IN	_	_	_	_	_
35	modulation	modulation	NOUN	NN	Number=Sing	_	_	_	_
36	of	of	ADP	IN	_	_	_	_	_
37	IkappaBalpha	IkappaBalpha	PROPN	NNP	Number=Sing	_	_	_	_
38	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
39	by	by	ADP	IN	_	_	_	_	_
40	cytokines	cytokine	NOUN	NNS	Number=Plur	_	_	_	_
41	or	or	CCONJ	CC	_	_	_	_	_
42	DEX	DEX	PROPN	NNP	Number=Sing	_	_	_	_
43	may	may	AUX	MD	VerbForm=Fin	_	_	_	_
44	lead	lead	VERB	VB	VerbForm=Inf	_	_	_	_
45	to	to	PART	TO	_	_	_	_	_
46	cell	cell	VERB	VB	VerbForm=Inf	_	_	_	_
47	survival	survival	NOUN	NN	Number=Sing	_	_	_	_
48	or	or	CCONJ	CC	_	_	_	_	_
49	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
50	death	death	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
51	,	,	PUNCT	,	_	_	_	_	_
52	respectively	respectively	ADV	RB	_	_	_	_	SpaceAfter=No
53	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 237
# text = Document 00300291 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	00300291	00300291	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 238
# text = Tissue-specific regulation of the rabbit 15-lipoxygenase gene in erythroid cells by a transcriptional silencer.
1	Tissue-	Tissue-	SYM	NFP	_	_	_	_	SpaceAfter=No
2	specific	specific	ADJ	JJ	Degree=Pos	_	_	_	_
3	regulation	regulation	NOUN	NN	Number=Sing	_	_	_	_
4	of	of	ADP	IN	_	_	_	_	_
5	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
6	rabbit	rabbit	NOUN	NN	Number=Sing	_	_	_	_
7	15	15	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
8	-	-	PUNCT	:	_	_	_	_	SpaceAfter=No
9	lipoxygenase	lipoxygenase	NOUN	NN	Number=Sing	_	_	_	_
10	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
11	in	in	ADP	IN	_	_	_	_	_
12	erythroid	erythroid	ADJ	JJ	Degree=Pos	_	_	_	_
13	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
14	by	by	ADP	IN	_	_	_	_	_
15	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
16	transcriptional	transcriptional	ADJ	JJ	Degree=Pos	_	_	_	_
17	silencer	silencer	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
18	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 239
# text = The 15-lipoxygenase (lox) gene is expressed in a tissue-specific manner, predominantly in erythroid cells but also in airway epithelial cells and eosinophils.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	15	15	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
3	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
4	lipoxygenase	lipoxygenase	NOUN	NN	Number=Sing	_	_	_	_
5	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
6	lox	lox	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
7	)	)	PUNCT	-RRB-	_	_	_	_	_
8	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
9	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
10	expressed	express	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
11	in	in	ADP	IN	_	_	_	_	_
12	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
13	tissue-	tissue-	SYM	SYM	_	_	_	_	SpaceAfter=No
14	specific	specific	ADJ	JJ	Degree=Pos	_	_	_	_
15	manner	manner	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
16	,	,	PUNCT	,	_	_	_	_	_
17	predominantly	predominantly	ADV	RB	_	_	_	_	_
18	in	in	ADP	IN	_	_	_	_	_
19	erythroid	erythroid	ADJ	JJ	Degree=Pos	_	_	_	_
20	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
21	but	but	CCONJ	CC	_	_	_	_	_
22	also	also	ADV	RB	_	_	_	_	_
23	in	in	ADP	IN	_	_	_	_	_
24	airway	airway	ADJ	JJ	Degree=Pos	_	_	_	_
25	epithelial	epithelial	ADJ	JJ	Degree=Pos	_	_	_	_
26	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
27	and	and	CCONJ	CC	_	_	_	_	_
28	eosinophils	eosinophil	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
29	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 240
# text = We demonstrate in this report that the 5' flanking DNA of the 15-lox gene contains sequences which down-regulate its activity in a variety of non-erythroid cell lines but not in two erythroid cell lines.
1	We	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
2	demonstrate	demonstrate	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
3	in	in	ADP	IN	_	_	_	_	_
4	this	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
5	report	report	NOUN	NN	Number=Sing	_	_	_	_
6	that	that	SCONJ	IN	_	_	_	_	_
7	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
8	5	5	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
9	'	'	PUNCT	``	_	_	_	_	_
10	flanking	flank	VERB	VBG	VerbForm=Ger	_	_	_	_
11	DNA	dna	NOUN	NN	Number=Sing	_	_	_	_
12	of	of	ADP	IN	_	_	_	_	_
13	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
14	15	15	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
15	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
16	lox	lox	NOUN	NN	Number=Sing	_	_	_	_
17	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
18	contains	contain	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
19	sequences	sequence	NOUN	NNS	Number=Plur	_	_	_	_
20	which	which	PRON	WDT	PronType=Rel	_	_	_	_
21	down	down	ADV	RB	_	_	_	_	SpaceAfter=No
22	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
23	regulate	regulate	VERB	VB	VerbForm=Inf	_	_	_	_
24	its	its	PRON	PRP$	Gender=Neut|Number=Sing|Person=3|Poss=Yes|PronType=Prs	_	_	_	_
25	activity	activity	NOUN	NN	Number=Sing	_	_	_	_
26	in	in	ADP	IN	_	_	_	_	_
27	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
28	variety	variety	NOUN	NN	Number=Sing	_	_	_	_
29	of	of	ADP	IN	_	_	_	_	_
30	non-erythroid	non-erythroid	ADJ	JJ	Degree=Pos	_	_	_	_
31	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
32	lines	line	NOUN	NNS	Number=Plur	_	_	_	_
33	but	but	CCONJ	CC	_	_	_	_	_
34	not	not	PART	RB	_	_	_	_	_
35	in	in	ADP	IN	_	_	_	_	_
36	two	two	NUM	CD	NumType=Card	_	_	_	_
37	erythroid	erythroid	ADJ	JJ	Degree=Pos	_	_	_	_
38	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
39	lines	line	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
40	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 241
# text = The element has characteristics of a transcriptional 'silencer' since it functions in both orientations.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	element	element	NOUN	NN	Number=Sing	_	_	_	_
3	has	have	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
4	characteristics	characteristic	NOUN	NNS	Number=Plur	_	_	_	_
5	of	of	ADP	IN	_	_	_	_	_
6	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
7	transcriptional	transcriptional	ADJ	JJ	Degree=Pos	_	_	_	_
8	'	'	PUNCT	``	_	_	_	_	SpaceAfter=No
9	silencer	silencer	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
10	'	'	PUNCT	''	_	_	_	_	_
11	since	since	SCONJ	IN	_	_	_	_	_
12	it	it	PRON	PRP	Case=Nom|Gender=Neut|Number=Sing|Person=3|PronType=Prs	_	_	_	_
13	functions	function	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
14	in	in	ADP	IN	_	_	_	_	_
15	both	both	DET	DT	_	_	_	_	_
16	orientations	orientation	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
17	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 242
# text = The main activity of the silencer has been mapped to the first 900 bp of 5' flanking DNA, which contains nine binding sites for a nuclear factor present in non-erythroid cells but not in erythroid cells.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	main	main	ADJ	JJ	Degree=Pos	_	_	_	_
3	activity	activity	NOUN	NN	Number=Sing	_	_	_	_
4	of	of	ADP	IN	_	_	_	_	_
5	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
6	silencer	silencer	NOUN	NN	Number=Sing	_	_	_	_
7	has	have	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
8	been	be	AUX	VBN	Tense=Past|VerbForm=Part	_	_	_	_
9	mapped	map	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
10	to	to	ADP	IN	_	_	_	_	_
11	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
12	first	first	ADJ	JJ	Degree=Pos|NumType=Ord	_	_	_	_
13	900	900	NUM	CD	NumType=Card	_	_	_	_
14	bp	bp	NOUN	NN	Number=Sing	_	_	_	_
15	of	of	ADP	IN	_	_	_	_	_
16	5	5	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
17	'	'	PUNCT	``	_	_	_	_	_
18	flanking	flanking	VERB	VBG	VerbForm=Ger	_	_	_	_
19	DNA	dna	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
20	,	,	PUNCT	,	_	_	_	_	_
21	which	which	PRON	WDT	PronType=Rel	_	_	_	_
22	contains	contain	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
23	nine	nine	NUM	CD	NumType=Card	_	_	_	_
24	binding	binding	VERB	VBG	VerbForm=Ger	_	_	_	_
25	sites	site	NOUN	NNS	Number=Plur	_	_	_	_
26	for	for	ADP	IN	_	_	_	_	_
27	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
28	nuclear	nuclear	ADJ	JJ	Degree=Pos	_	_	_	_
29	factor	factor	NOUN	NN	Number=Sing	_	_	_	_
30	present	present	ADJ	JJ	Degree=Pos	_	_	_	_
31	in	in	ADP	IN	_	_	_	_	_
32	non-erythroid	non-erythroid	ADJ	JJ	Degree=Pos	_	_	_	_
33	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
34	but	but	CCONJ	CC	_	_	_	_	_
35	not	not	PART	RB	_	_	_	_	_
36	in	in	ADP	IN	_	_	_	_	_
37	erythroid	erythroid	ADJ	JJ	Degree=Pos	_	_	_	_
38	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
39	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 243
# text = These binding sites have similar sequences and multiple copies of the binding sites confer tissue-specific down-regulation when attached to a minimal lox promoter fragment.
1	These	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
2	binding	binding	ADJ	JJ	Degree=Pos	_	_	_	_
3	sites	site	NOUN	NNS	Number=Plur	_	_	_	_
4	have	have	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
5	similar	similar	ADJ	JJ	Degree=Pos	_	_	_	_
6	sequences	sequence	NOUN	NNS	Number=Plur	_	_	_	_
7	and	and	CCONJ	CC	_	_	_	_	_
8	multiple	multiple	ADJ	JJ	Degree=Pos	_	_	_	_
9	copies	copy	NOUN	NNS	Number=Plur	_	_	_	_
10	of	of	ADP	IN	_	_	_	_	_
11	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
12	binding	binding	VERB	VBG	VerbForm=Ger	_	_	_	_
13	sites	site	NOUN	NNS	Number=Plur	_	_	_	_
14	confer	confer	NOUN	NN	Number=Sing	_	_	_	_
15	tissue-	tissue-	SYM	SYM	_	_	_	_	SpaceAfter=No
16	specific	specific	ADJ	JJ	Degree=Pos	_	_	_	_
17	down	down	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
18	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
19	regulation	regulation	NOUN	NN	Number=Sing	_	_	_	_
20	when	when	ADV	WRB	PronType=Int	_	_	_	_
21	attached	attach	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
22	to	to	ADP	IN	_	_	_	_	_
23	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
24	minimal	minimal	ADJ	JJ	Degree=Pos	_	_	_	_
25	lox	lox	NOUN	NN	Number=Sing	_	_	_	_
26	promoter	promoter	NOUN	NN	Number=Sing	_	_	_	_
27	fragment	fragment	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
28	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 244
# text = The 5' flanking DNA also contains a cluster of three binding sites for the GATA family of transcription factors.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	5	5	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
3	'	'	PUNCT	``	_	_	_	_	_
4	flanking	flanking	VERB	VBG	VerbForm=Ger	_	_	_	_
5	DNA	dna	NOUN	NN	Number=Sing	_	_	_	_
6	also	also	ADV	RB	_	_	_	_	_
7	contains	contain	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
8	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
9	cluster	cluster	NOUN	NN	Number=Sing	_	_	_	_
10	of	of	ADP	IN	_	_	_	_	_
11	three	three	NUM	CD	NumType=Card	_	_	_	_
12	binding	binding	VERB	VBG	VerbForm=Ger	_	_	_	_
13	sites	site	NOUN	NNS	Number=Plur	_	_	_	_
14	for	for	ADP	IN	_	_	_	_	_
15	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
16	GATA	GATA	PROPN	NNP	Number=Sing	_	_	_	_
17	family	family	NOUN	NN	Number=Sing	_	_	_	_
18	of	of	ADP	IN	_	_	_	_	_
19	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
20	factors	factor	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
21	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 245
# text = Document 00300292 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	00300292	00300292	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 246
# text = Nuclear appearance of a factor that binds the CD28 response element within the interleukin-2 enhancer correlates with interleukin-2 production.
1	Nuclear	nuclear	ADJ	JJ	Degree=Pos	_	_	_	_
2	appearance	appearance	NOUN	NN	Number=Sing	_	_	_	_
3	of	of	ADP	IN	_	_	_	_	_
4	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
5	factor	factor	NOUN	NN	Number=Sing	_	_	_	_
6	that	that	PRON	WDT	PronType=Rel	_	_	_	_
7	binds	bind	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
8	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
9	CD28	CD28	PROPN	NNP	Number=Sing	_	_	_	_
10	response	response	NOUN	NN	Number=Sing	_	_	_	_
11	element	element	NOUN	NN	Number=Sing	_	_	_	_
12	within	within	ADP	IN	_	_	_	_	_
13	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
14	interleukin	interleukin	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
15	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
16	2	2	NUM	CD	NumType=Card	_	_	_	_
17	enhancer	enhancer	NOUN	NN	Number=Sing	_	_	_	_
18	correlates	correlate	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
19	with	with	ADP	IN	_	_	_	_	_
20	interleukin	interleukin	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
21	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
22	2	2	NUM	CD	NumType=Card	_	_	_	_
23	production	production	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
24	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 247
# text = Activation of T lymphocytes requires the combined signaling of the T cell receptor and costimulatory molecules such as CD28.
1	Activation	Activation	NOUN	NN	Number=Sing	_	_	_	_
2	of	of	ADP	IN	_	_	_	_	_
3	T	t	PROPN	NNP	Number=Sing	_	_	_	_
4	lymphocytes	lymphocyte	NOUN	NNS	Number=Plur	_	_	_	_
5	requires	require	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
6	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
7	combined	combine	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
8	signaling	signaling	NOUN	NN	Number=Sing	_	_	_	_
9	of	of	ADP	IN	_	_	_	_	_
10	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
11	T	T	PROPN	NNP	Number=Sing	_	_	_	_
12	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
13	receptor	receptor	NOUN	NN	Number=Sing	_	_	_	_
14	and	and	CCONJ	CC	_	_	_	_	_
15	costimulatory	costimulatory	ADJ	JJ	Degree=Pos	_	_	_	_
16	molecules	molecule	NOUN	NNS	Number=Plur	_	_	_	_
17	such	such	ADJ	JJ	Degree=Pos	_	_	_	_
18	as	as	ADP	IN	_	_	_	_	_
19	CD28	CD28	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
20	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 248
# text = The ability of T cells to produce interleukin-2 (IL-2) is a critical control point in T lymphocyte activation.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	ability	ability	NOUN	NN	Number=Sing	_	_	_	_
3	of	of	ADP	IN	_	_	_	_	_
4	T	t	PROPN	NNP	Number=Sing	_	_	_	_
5	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
6	to	to	PART	TO	_	_	_	_	_
7	produce	produce	VERB	VB	VerbForm=Inf	_	_	_	_
8	interleukin	interleukin	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
9	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
10	2	2	NUM	CD	NumType=Card	_	_	_	_
11	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
12	IL	Il	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
13	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
14	2	2	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
15	)	)	PUNCT	-RRB-	_	_	_	_	_
16	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
17	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
18	critical	critical	ADJ	JJ	Degree=Pos	_	_	_	_
19	control	control	NOUN	NN	Number=Sing	_	_	_	_
20	point	point	NOUN	NN	Number=Sing	_	_	_	_
21	in	in	ADP	IN	_	_	_	_	_
22	T	t	PROPN	NNP	Number=Sing	_	_	_	_
23	lymphocyte	lymphocyte	NOUN	NN	Number=Sing	_	_	_	_
24	activation	activation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
25	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 249
# text = The IL-2 enhancer contains a functional motif named CD28 response element (CD28RE) that serves a role as a target for mitogenic T cell activation signals.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	IL	Il	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
3	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
4	2	2	NUM	CD	NumType=Card	_	_	_	_
5	enhancer	enhancer	NOUN	NN	Number=Sing	_	_	_	_
6	contains	contain	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
7	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
8	functional	functional	ADJ	JJ	Degree=Pos	_	_	_	_
9	motif	motif	NOUN	NN	Number=Sing	_	_	_	_
10	named	name	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
11	CD28	CD28	NUM	CD	NumType=Card	_	_	_	_
12	response	response	NOUN	NN	Number=Sing	_	_	_	_
13	element	element	NOUN	NN	Number=Sing	_	_	_	_
14	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
15	CD28RE	CD28RE	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
16	)	)	PUNCT	-RRB-	_	_	_	_	_
17	that	that	PRON	WDT	PronType=Rel	_	_	_	_
18	serves	serve	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
19	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
20	role	role	NOUN	NN	Number=Sing	_	_	_	_
21	as	as	ADP	IN	_	_	_	_	_
22	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
23	target	target	NOUN	NN	Number=Sing	_	_	_	_
24	for	for	ADP	IN	_	_	_	_	_
25	mitogenic	mitogenic	ADJ	JJ	Degree=Pos	_	_	_	_
26	T	t	PROPN	NNP	Number=Sing	_	_	_	_
27	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
28	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
29	signals	signal	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
30	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 250
# text = The CD28RE sequence reveals similarity to the consensus kappaB binding motif.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	CD28RE	Cd28re	NOUN	NN	Number=Sing	_	_	_	_
3	sequence	sequence	NOUN	NN	Number=Sing	_	_	_	_
4	reveals	reveal	NOUN	NNS	Number=Plur	_	_	_	_
5	similarity	similarity	NOUN	NN	Number=Sing	_	_	_	_
6	to	to	ADP	IN	_	_	_	_	_
7	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
8	consensus	consensus	NOUN	NN	Number=Sing	_	_	_	_
9	kappaB	kappaB	NOUN	NN	Number=Sing	_	_	_	_
10	binding	binding	VERB	VBG	VerbForm=Ger	_	_	_	_
11	motif	motif	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
12	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 251
# text = Here we demonstrate that CD28RE binds an inducible protein with a molecular mass of approximately 35 kDa called nuclear factor of mitogenic-activated T cells (NF-MATp35) that is clearly different from the known NF- kappaB/Rel family members.
1	Here	here	ADV	RB	PronType=Dem	_	_	_	_
2	we	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
3	demonstrate	demonstrate	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
4	that	that	SCONJ	IN	_	_	_	_	_
5	CD28RE	Cd28re	PRON	EX	_	_	_	_	_
6	binds	bind	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
7	an	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
8	inducible	inducible	ADJ	JJ	Degree=Pos	_	_	_	_
9	protein	protein	NOUN	NN	Number=Sing	_	_	_	_
10	with	with	ADP	IN	_	_	_	_	_
11	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
12	molecular	molecular	ADJ	JJ	Degree=Pos	_	_	_	_
13	mass	mass	NOUN	NN	Number=Sing	_	_	_	_
14	of	of	ADP	IN	_	_	_	_	_
15	approximately	approximately	ADV	RB	_	_	_	_	_
16	35	35	NUM	CD	NumType=Card	_	_	_	_
17	kDa	kDa	PROPN	NNP	Number=Sing	_	_	_	_
18	called	call	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
19	nuclear	nuclear	ADJ	JJ	Degree=Pos	_	_	_	_
20	factor	factor	NOUN	NN	Number=Sing	_	_	_	_
21	of	of	ADP	IN	_	_	_	_	_
22	mitogenic	mitogenic	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
23	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
24	activated	activate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
25	T	T	PROPN	NNP	Number=Sing	_	_	_	_
26	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
27	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
28	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
29	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
30	MATp35	MATp35	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
31	)	)	PUNCT	-RRB-	_	_	_	_	_
32	that	that	PRON	WDT	PronType=Rel	_	_	_	_
33	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
34	clearly	clearly	ADV	RB	_	_	_	_	_
35	different	different	ADJ	JJ	Degree=Pos	_	_	_	_
36	from	from	ADP	IN	_	_	_	_	_
37	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
38	known	know	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
39	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
40	-	-	PUNCT	HYPH	_	_	_	_	_
41	kappaB	kappaB	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
42	/	/	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
43	Rel	Rel	PROPN	NNP	Number=Sing	_	_	_	_
44	family	family	NOUN	NN	Number=Sing	_	_	_	_
45	members	member	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
46	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 252
# text = Induction of NF-MATp35 was shown to depend on de novo protein synthesis and was restricted to T cells that received a mitogenic combination of T cell stimuli, not necessarily including CD28 signaling.
1	Induction	Induction	NOUN	NN	Number=Sing	_	_	_	_
2	of	of	ADP	IN	_	_	_	_	_
3	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
4	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
5	MATp35	MATp35	PROPN	NNP	Number=Sing	_	_	_	_
6	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
7	shown	show	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
8	to	to	PART	TO	_	_	_	_	_
9	depend	depend	VERB	VB	VerbForm=Inf	_	_	_	_
10	on	on	ADP	IN	_	_	_	_	_
11	de	de	NOUN	NN	Number=Sing	_	_	_	_
12	novo	novo	NOUN	NN	Number=Sing	_	_	_	_
13	protein	protein	NOUN	NN	Number=Sing	_	_	_	_
14	synthesis	synthesis	NOUN	NN	Number=Sing	_	_	_	_
15	and	and	CCONJ	CC	_	_	_	_	_
16	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=1|Tense=Past|VerbForm=Fin	_	_	_	_
17	restricted	restrict	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
18	to	to	PART	TO	_	_	_	_	_
19	T	t	VERB	VB	VerbForm=Inf	_	_	_	_
20	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
21	that	that	PRON	WDT	PronType=Rel	_	_	_	_
22	received	receive	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
23	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
24	mitogenic	mitogenic	ADJ	JJ	Degree=Pos	_	_	_	_
25	combination	combination	NOUN	NN	Number=Sing	_	_	_	_
26	of	of	ADP	IN	_	_	_	_	_
27	T	t	PROPN	NNP	Number=Sing	_	_	_	_
28	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
29	stimuli	stimuli	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
30	,	,	PUNCT	,	_	_	_	_	_
31	not	not	ADV	RB	_	_	_	_	_
32	necessarily	necessarily	ADV	RB	_	_	_	_	_
33	including	include	VERB	VBG	VerbForm=Ger	_	_	_	_
34	CD28	CD28	NUM	CD	NumType=Card	_	_	_	_
35	signaling	signaling	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
36	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 253
# text = Nonmitogenic T cell stimulation did not result in appearance of NF-MATp35.
1	Nonmitogenic	Nonmitogenic	PROPN	NNP	Number=Sing	_	_	_	_
2	T	T	PROPN	NNP	Number=Sing	_	_	_	_
3	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
4	stimulation	stimulation	NOUN	NN	Number=Sing	_	_	_	_
5	did	do	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
6	not	not	PART	RB	_	_	_	_	_
7	result	result	VERB	VB	VerbForm=Inf	_	_	_	_
8	in	in	ADP	IN	_	_	_	_	_
9	appearance	appearance	NOUN	NN	Number=Sing	_	_	_	_
10	of	of	ADP	IN	_	_	_	_	_
11	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
12	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
13	MATp35	MATp35	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
14	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 254
# text = These results indicate that mitogenic combinations of T cell activation signals are integrated at the level of NF-MATp35 induction.
1	These	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
2	results	result	NOUN	NNS	Number=Plur	_	_	_	_
3	indicate	indicate	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
4	that	that	SCONJ	IN	_	_	_	_	_
5	mitogenic	mitogenic	ADJ	JJ	Degree=Pos	_	_	_	_
6	combinations	combination	NOUN	NNS	Number=Plur	_	_	_	_
7	of	of	ADP	IN	_	_	_	_	_
8	T	t	PROPN	NNP	Number=Sing	_	_	_	_
9	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
10	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
11	signals	signal	NOUN	NNS	Number=Plur	_	_	_	_
12	are	be	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
13	integrated	integrate	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
14	at	at	ADP	IN	_	_	_	_	_
15	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
16	level	level	NOUN	NN	Number=Sing	_	_	_	_
17	of	of	ADP	IN	_	_	_	_	_
18	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
19	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
20	MATp35	MATp35	PROPN	NNP	Number=Sing	_	_	_	_
21	induction	induction	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
22	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 255
# text = Similar to its effect on IL-2 production, cyclosporin
1	Similar	similar	ADJ	JJ	Degree=Pos	_	_	_	_
2	to	to	ADP	IN	_	_	_	_	_
3	its	its	PRON	PRP$	Gender=Neut|Number=Sing|Person=3|Poss=Yes|PronType=Prs	_	_	_	_
4	effect	effect	NOUN	NN	Number=Sing	_	_	_	_
5	on	on	ADP	IN	_	_	_	_	_
6	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
7	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
8	2	2	NUM	CD	NumType=Card	_	_	_	_
9	production	production	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
10	,	,	PUNCT	,	_	_	_	_	_
11	cyclosporin	cyclosporin	NOUN	NN	Number=Sing	_	_	_	_

# sent_id = 256
# text = A inhibited the induction of NF-MATp35.
1	A	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
2	inhibited	inhibit	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
3	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
4	induction	induction	NOUN	NN	Number=Sing	_	_	_	_
5	of	of	ADP	IN	_	_	_	_	_
6	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
7	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
8	MATp35	MATp35	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
9	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 257
# text = Taken together, these data demonstrate that the nuclear appearance of NF-MATp35 shows excellent correlation with IL-2 production, which is a unique characteristic among nuclear factors implicated in the control of IL-2 gene expression.
1	Taken	take	PROPN	NNP	Number=Sing	_	_	_	_
2	together	together	ADV	RB	_	_	_	_	SpaceAfter=No
3	,	,	PUNCT	,	_	_	_	_	_
4	these	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
5	data	data	NOUN	NN	Number=Sing	_	_	_	_
6	demonstrate	demonstrate	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
7	that	that	SCONJ	IN	_	_	_	_	_
8	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
9	nuclear	nuclear	ADJ	JJ	Degree=Pos	_	_	_	_
10	appearance	appearance	NOUN	NN	Number=Sing	_	_	_	_
11	of	of	ADP	IN	_	_	_	_	_
12	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
13	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
14	MATp35	MATp35	PROPN	NNP	Number=Sing	_	_	_	_
15	shows	show	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
16	excellent	excellent	ADJ	JJ	Degree=Pos	_	_	_	_
17	correlation	correlation	NOUN	NN	Number=Sing	_	_	_	_
18	with	with	ADP	IN	_	_	_	_	_
19	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
20	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
21	2	2	NUM	CD	NumType=Card	_	_	_	_
22	production	production	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
23	,	,	PUNCT	,	_	_	_	_	_
24	which	which	PRON	WDT	PronType=Rel	_	_	_	_
25	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
26	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
27	unique	unique	ADJ	JJ	Degree=Pos	_	_	_	_
28	characteristic	characteristic	NOUN	NN	Number=Sing	_	_	_	_
29	among	among	ADP	IN	_	_	_	_	_
30	nuclear	nuclear	ADJ	JJ	Degree=Pos	_	_	_	_
31	factors	factor	NOUN	NNS	Number=Plur	_	_	_	_
32	implicated	implicate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
33	in	in	ADP	IN	_	_	_	_	_
34	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
35	control	control	NOUN	NN	Number=Sing	_	_	_	_
36	of	of	ADP	IN	_	_	_	_	_
37	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
38	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
39	2	2	NUM	CD	NumType=Card	_	_	_	_
40	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
41	expression	expression	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
42	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 258
# text = Document 00300298 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	00300298	00300298	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 259
# text = Regulation of Id3 cell cycle function by Cdk-2-dependent phosphorylation.
1	Regulation	regulation	NOUN	NN	Number=Sing	_	_	_	_
2	of	of	ADP	IN	_	_	_	_	_
3	Id3	Id3	NUM	CD	NumType=Card	_	_	_	_
4	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
5	cycle	cycle	NOUN	NN	Number=Sing	_	_	_	_
6	function	function	NOUN	NN	Number=Sing	_	_	_	_
7	by	by	ADP	IN	_	_	_	_	_
8	Cdk	Cdk	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
9	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
10	2	2	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
11	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
12	dependent	dependent	ADJ	JJ	Degree=Pos	_	_	_	_
13	phosphorylation	phosphorylation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
14	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 260
# text = The functions of basic helix-loop-helix (bHLH) transcription factors in activating differentiation-linked gene expression and in inducing G1 cell cycle arrest are negatively regulated by members of the Id family of HLH proteins.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	functions	function	NOUN	NNS	Number=Plur	_	_	_	_
3	of	of	ADP	IN	_	_	_	_	_
4	basic	basic	ADJ	JJ	Degree=Pos	_	_	_	_
5	helix-loop	helix-loop	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
6	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
7	helix	helix	NOUN	NN	Number=Sing	_	_	_	_
8	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
9	bHLH	bHLH	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
10	)	)	PUNCT	-RRB-	_	_	_	_	_
11	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
12	factors	factor	NOUN	NNS	Number=Plur	_	_	_	_
13	in	in	SCONJ	IN	_	_	_	_	_
14	activating	activate	VERB	VBG	VerbForm=Ger	_	_	_	_
15	differentiation	differentiation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
16	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
17	linked	link	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
18	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
19	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
20	and	and	CCONJ	CC	_	_	_	_	_
21	in	in	SCONJ	IN	_	_	_	_	_
22	inducing	induce	VERB	VBG	VerbForm=Ger	_	_	_	_
23	G1	G1	NUM	CD	NumType=Card	_	_	_	_
24	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
25	cycle	cycle	NOUN	NN	Number=Sing	_	_	_	_
26	arrest	arrest	NOUN	NN	Number=Sing	_	_	_	_
27	are	be	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
28	negatively	negatively	ADV	RB	_	_	_	_	_
29	regulated	regulate	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
30	by	by	ADP	IN	_	_	_	_	_
31	members	member	NOUN	NNS	Number=Plur	_	_	_	_
32	of	of	ADP	IN	_	_	_	_	_
33	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
34	Id	id	PROPN	NNP	Number=Sing	_	_	_	_
35	family	family	NOUN	NN	Number=Sing	_	_	_	_
36	of	of	ADP	IN	_	_	_	_	_
37	HLH	Hlh	DET	DT	_	_	_	_	_
38	proteins	protein	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
39	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 261
# text = These bHLH antagonists are induced during a mitogenic signalling response, and they function by sequestering their bHLH targets in inactive heterodimers that are unable to bind to specific gene regulatory (E box) sequences.
1	These	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
2	bHLH	bhlh	ADJ	JJ	Degree=Pos	_	_	_	_
3	antagonists	antagonist	NOUN	NNS	Number=Plur	_	_	_	_
4	are	be	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
5	induced	induce	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
6	during	during	ADP	IN	_	_	_	_	_
7	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
8	mitogenic	mitogenic	ADJ	JJ	Degree=Pos	_	_	_	_
9	signalling	signalling	NOUN	NN	Number=Sing	_	_	_	_
10	response	response	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
11	,	,	PUNCT	,	_	_	_	_	_
12	and	and	CCONJ	CC	_	_	_	_	_
13	they	they	PRON	PRP	Case=Nom|Number=Plur|Person=3|PronType=Prs	_	_	_	_
14	function	function	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
15	by	by	SCONJ	IN	_	_	_	_	_
16	sequestering	sequester	VERB	VBG	VerbForm=Ger	_	_	_	_
17	their	they	PRON	PRP$	Number=Plur|Person=3|Poss=Yes|PronType=Prs	_	_	_	_
18	bHLH	bHLh	NOUN	NN	Number=Sing	_	_	_	_
19	targets	target	NOUN	NNS	Number=Plur	_	_	_	_
20	in	in	ADP	IN	_	_	_	_	_
21	inactive	inactive	ADJ	JJ	Degree=Pos	_	_	_	_
22	heterodimers	heterodimer	NOUN	NNS	Number=Plur	_	_	_	_
23	that	that	PRON	WDT	PronType=Rel	_	_	_	_
24	are	be	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
25	unable	unable	ADJ	JJ	Degree=Pos	_	_	_	_
26	to	to	PART	TO	_	_	_	_	_
27	bind	bind	VERB	VB	VerbForm=Inf	_	_	_	_
28	to	to	ADP	IN	_	_	_	_	_
29	specific	specific	ADJ	JJ	Degree=Pos	_	_	_	_
30	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
31	regulatory	regulatory	ADJ	JJ	Degree=Pos	_	_	_	_
32	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
33	E	e	NOUN	NN	Number=Sing	_	_	_	_
34	box	box	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
35	)	)	PUNCT	-RRB-	_	_	_	_	_
36	sequences	sequence	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
37	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 262
# text = Recently, cyclin E-Cdk2- and cyclin A-Cdk2-dependent phosphorylation of a single conserved serine residue (Ser5) in Id2 has been shown to occur during late G1-to-S phase transition of the cell cycle, and this neutralizes the function of Id2 in abrogating E-box-dependent bHLH homo- or heterodimer complex formation in vitro (E.Hara, M.Hall, and G.Peters, EMBO J.16:332-342, 1997).
1	Recently	recently	ADV	RB	_	_	_	_	SpaceAfter=No
2	,	,	PUNCT	,	_	_	_	_	_
3	cyclin	cyclin	NOUN	NN	Number=Sing	_	_	_	_
4	E-	e-	PUNCT	:	_	_	_	_	SpaceAfter=No
5	Cdk2	cdk2	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
6	-	-	PUNCT	,	_	_	_	_	_
7	and	and	CCONJ	CC	_	_	_	_	_
8	cyclin	cyclin	NOUN	NN	Number=Sing	_	_	_	_
9	A-Cdk2	A-Cdk2	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
10	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
11	dependent	dependent	ADJ	JJ	Degree=Pos	_	_	_	_
12	phosphorylation	phosphorylation	NOUN	NN	Number=Sing	_	_	_	_
13	of	of	ADP	IN	_	_	_	_	_
14	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
15	single	single	ADJ	JJ	Degree=Pos	_	_	_	_
16	conserved	conserve	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
17	serine	serine	NOUN	NN	Number=Sing	_	_	_	_
18	residue	residue	NOUN	NN	Number=Sing	_	_	_	_
19	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
20	Ser5	Ser5	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
21	)	)	PUNCT	-RRB-	_	_	_	_	_
22	in	in	ADP	IN	_	_	_	_	_
23	Id2	id2	NOUN	NN	Number=Sing	_	_	_	_
24	has	have	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
25	been	be	AUX	VBN	Tense=Past|VerbForm=Part	_	_	_	_
26	shown	show	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
27	to	to	PART	TO	_	_	_	_	_
28	occur	occur	VERB	VB	VerbForm=Inf	_	_	_	_
29	during	during	ADP	IN	_	_	_	_	_
30	late	late	ADJ	JJ	Degree=Pos	_	_	_	_
31	G1	g1	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
32	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
33	to	to	ADP	IN	_	_	_	_	SpaceAfter=No
34	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
35	S	s	NOUN	NN	Number=Sing	_	_	_	_
36	phase	phase	NOUN	NN	Number=Sing	_	_	_	_
37	transition	transition	NOUN	NN	Number=Sing	_	_	_	_
38	of	of	ADP	IN	_	_	_	_	_
39	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
40	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
41	cycle	cycle	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
42	,	,	PUNCT	,	_	_	_	_	_
43	and	and	CCONJ	CC	_	_	_	_	_
44	this	this	PRON	DT	Number=Sing|PronType=Dem	_	_	_	_
45	neutralizes	neutralize	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
46	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
47	function	function	NOUN	NN	Number=Sing	_	_	_	_
48	of	of	ADP	IN	_	_	_	_	_
49	Id2	Id2	NUM	CD	NumType=Card	_	_	_	_
50	in	in	SCONJ	IN	_	_	_	_	_
51	abrogating	abrogat	VERB	VBG	VerbForm=Ger	_	_	_	_
52	E-	e-	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
53	box	box	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
54	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
55	dependent	dependent	ADJ	JJ	Degree=Pos	_	_	_	_
56	bHLH	bHLh	NOUN	NN	Number=Sing	_	_	_	_
57	homo	homo	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
58	-	-	PUNCT	,	_	_	_	_	_
59	or	or	CCONJ	CC	_	_	_	_	_
60	heterodimer	heterodimer	ADJ	JJR	Degree=Cmp	_	_	_	_
61	complex	complex	ADJ	JJ	Degree=Pos	_	_	_	_
62	formation	formation	NOUN	NN	Number=Sing	_	_	_	_
63	in	in	ADP	IN	_	_	_	_	_
64	vitro	vitro	PROPN	NNP	Number=Sing	_	_	_	_
65	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
66	E.Hara	E.Hara	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
67	,	,	PUNCT	,	_	_	_	_	_
68	M.Hall	M.Hall	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
69	,	,	PUNCT	,	_	_	_	_	_
70	and	and	CCONJ	CC	_	_	_	_	_
71	G.Peters	G.Peters	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
72	,	,	PUNCT	,	_	_	_	_	_
73	EMBO	EMBO	PROPN	NNP	Number=Sing	_	_	_	_
74	J.16:332-342	J.16:332-342	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
75	,	,	PUNCT	,	_	_	_	_	_
76	1997	1997	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
77	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
78	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 263
# text = We now show that an analogous cell-cycle-regulated phosphorylation of Id3 alters the specificity of Id3 for abrogating both E-box-dependent bHLH homo- or heterodimer complex formation in vitro and E-box-dependent reporter gene function in vivo.
1	We	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
2	now	now	ADV	RB	_	_	_	_	_
3	show	show	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
4	that	that	SCONJ	IN	_	_	_	_	_
5	an	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
6	analogous	analogous	ADJ	JJ	Degree=Pos	_	_	_	_
7	cell	cell	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
8	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
9	cycle-regulated	cycle-regulated	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
10	phosphorylation	phosphorylation	NOUN	NN	Number=Sing	_	_	_	_
11	of	of	ADP	IN	_	_	_	_	_
12	Id3	Id3	NUM	CD	NumType=Card	_	_	_	_
13	alters	alter	NOUN	NNS	Number=Plur	_	_	_	_
14	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
15	specificity	specificity	NOUN	NN	Number=Sing	_	_	_	_
16	of	of	ADP	IN	_	_	_	_	_
17	Id3	Id3	NOUN	NN	Number=Sing	_	_	_	_
18	for	for	SCONJ	IN	_	_	_	_	_
19	abrogating	abrogat	VERB	VBG	VerbForm=Ger	_	_	_	_
20	both	both	DET	DT	_	_	_	_	_
21	E-	e-	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
22	box	box	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
23	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
24	dependent	dependent	ADJ	JJ	Degree=Pos	_	_	_	_
25	bHLH	bHLh	NOUN	NN	Number=Sing	_	_	_	_
26	homo	homo	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
27	-	-	PUNCT	,	_	_	_	_	_
28	or	or	CCONJ	CC	_	_	_	_	_
29	heterodimer	heterodimer	ADJ	JJR	Degree=Cmp	_	_	_	_
30	complex	complex	ADJ	JJ	Degree=Pos	_	_	_	_
31	formation	formation	NOUN	NN	Number=Sing	_	_	_	_
32	in	in	ADP	IN	_	_	_	_	_
33	vitro	vitro	NOUN	NN	Number=Sing	_	_	_	_
34	and	and	CCONJ	CC	_	_	_	_	_
35	E-	e-	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
36	box	box	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
37	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
38	dependent	dependent	ADJ	JJ	Degree=Pos	_	_	_	_
39	reporter	reporter	NOUN	NN	Number=Sing	_	_	_	_
40	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
41	function	function	NOUN	NN	Number=Sing	_	_	_	_
42	in	in	ADP	IN	_	_	_	_	_
43	vivo.	vivo.	NOUN	NN	Number=Sing	_	_	_	_

# sent_id = 264
# text = Furthermore, compared with wild-type Id3, an Id3 Asp5 mutant (mimicking phosphorylation) is unable to promote cell cycle S phase entry in transfected fibroblasts, whereas an Id3 Ala5 mutant (ablating phosphorylation) displays an activity significantly greater than that of wild-type Id3 protein.
1	Furthermore	furthermore	ADV	RB	_	_	_	_	SpaceAfter=No
2	,	,	PUNCT	,	_	_	_	_	_
3	compared	compare	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
4	with	with	ADP	IN	_	_	_	_	_
5	wild	wild	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
6	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
7	type	type	NOUN	NN	Number=Sing	_	_	_	_
8	Id3	Id3	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
9	,	,	PUNCT	,	_	_	_	_	_
10	an	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
11	Id3	Id3	NUM	CD	NumType=Card	_	_	_	_
12	Asp5	asp5	NOUN	NN	Number=Sing	_	_	_	_
13	mutant	mutant	NOUN	NN	Number=Sing	_	_	_	_
14	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
15	mimicking	mimicking	NOUN	NN	Number=Sing	_	_	_	_
16	phosphorylation	phosphorylation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
17	)	)	PUNCT	-RRB-	_	_	_	_	_
18	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
19	unable	unable	ADJ	JJ	Degree=Pos	_	_	_	_
20	to	to	PART	TO	_	_	_	_	_
21	promote	promote	VERB	VB	VerbForm=Inf	_	_	_	_
22	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
23	cycle	cycle	NOUN	NN	Number=Sing	_	_	_	_
24	S	's	PART	POS	_	_	_	_	_
25	phase	phase	NOUN	NN	Number=Sing	_	_	_	_
26	entry	entry	NOUN	NN	Number=Sing	_	_	_	_
27	in	in	ADP	IN	_	_	_	_	_
28	transfected	transfect	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
29	fibroblasts	fibroblast	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
30	,	,	PUNCT	,	_	_	_	_	_
31	whereas	whereas	SCONJ	IN	_	_	_	_	_
32	an	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
33	Id3	Id3	NOUN	NN	Number=Sing	_	_	_	_
34	Ala5	ala5	NOUN	NN	Number=Sing	_	_	_	_
35	mutant	mutant	NOUN	NN	Number=Sing	_	_	_	_
36	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
37	ablating	ablat	VERB	VBG	VerbForm=Ger	_	_	_	_
38	phosphorylation	phosphorylation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
39	)	)	PUNCT	-RRB-	_	_	_	_	_
40	displays	display	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
41	an	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
42	activity	activity	NOUN	NN	Number=Sing	_	_	_	_
43	significantly	significantly	ADV	RB	_	_	_	_	_
44	greater	greater	ADJ	JJR	Degree=Cmp	_	_	_	_
45	than	than	ADP	IN	_	_	_	_	_
46	that	that	PRON	DT	Number=Sing|PronType=Dem	_	_	_	_
47	of	of	ADP	IN	_	_	_	_	_
48	wild	wild	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
49	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
50	type	type	NOUN	NN	Number=Sing	_	_	_	_
51	Id3	Id3	NUM	CD	NumType=Card	_	_	_	_
52	protein	protein	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
53	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 265
# text = Cdk2-dependent phosphorylation therefore provides a switch during late G1-to-S phase that both nullifies an early G1 cell cycle regulatory function of Id3 and modulates its target bHLH specificity.
1	Cdk2	Cdk2	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
2	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
3	dependent	dependent	ADJ	JJ	Degree=Pos	_	_	_	_
4	phosphorylation	phosphorylation	NOUN	NN	Number=Sing	_	_	_	_
5	therefore	therefore	ADV	RB	_	_	_	_	_
6	provides	provide	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
7	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
8	switch	switch	NOUN	NN	Number=Sing	_	_	_	_
9	during	during	ADP	IN	_	_	_	_	_
10	late	late	ADJ	JJ	Degree=Pos	_	_	_	_
11	G1	G1	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
12	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
13	to	to	ADP	IN	_	_	_	_	SpaceAfter=No
14	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
15	S	S	NOUN	NN	Number=Sing	_	_	_	_
16	phase	phase	NOUN	NN	Number=Sing	_	_	_	_
17	that	that	PRON	WDT	PronType=Rel	_	_	_	_
18	both	both	ADV	RB	_	_	_	_	_
19	nullifies	nullify	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
20	an	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
21	early	early	ADJ	JJ	Degree=Pos	_	_	_	_
22	G1	g1	NOUN	NN	Number=Sing	_	_	_	_
23	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
24	cycle	cycle	NOUN	NN	Number=Sing	_	_	_	_
25	regulatory	regulatory	ADJ	JJ	Degree=Pos	_	_	_	_
26	function	function	NOUN	NN	Number=Sing	_	_	_	_
27	of	of	ADP	IN	_	_	_	_	_
28	Id3	Id3	NUM	CD	NumType=Card	_	_	_	_
29	and	and	CCONJ	CC	_	_	_	_	_
30	modulates	modulate	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
31	its	its	PRON	PRP$	Gender=Neut|Number=Sing|Person=3|Poss=Yes|PronType=Prs	_	_	_	_
32	target	target	NOUN	NN	Number=Sing	_	_	_	_
33	bHLH	bHLh	NOUN	NN	Number=Sing	_	_	_	_
34	specificity	specificity	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
35	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 266
# text = These data also demonstrate that the ability of Id3 to promote cell cycle S phase entry is not simply a function of its ability to modulate bHLH heterodimer-dependent gene expression and establish a biologically important mechanism through which Cdk2 and
1	These	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
2	data	data	NOUN	NN	Number=Sing	_	_	_	_
3	also	also	ADV	RB	_	_	_	_	_
4	demonstrate	demonstrate	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
5	that	that	SCONJ	IN	_	_	_	_	_
6	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
7	ability	ability	NOUN	NN	Number=Sing	_	_	_	_
8	of	of	ADP	IN	_	_	_	_	_
9	Id3	Id3	NOUN	NN	Number=Sing	_	_	_	_
10	to	to	PART	TO	_	_	_	_	_
11	promote	promote	VERB	VB	VerbForm=Inf	_	_	_	_
12	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
13	cycle	cycle	NOUN	NN	Number=Sing	_	_	_	_
14	S	's	PART	POS	_	_	_	_	_
15	phase	phase	NOUN	NN	Number=Sing	_	_	_	_
16	entry	entry	NOUN	NN	Number=Sing	_	_	_	_
17	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
18	not	not	PART	RB	_	_	_	_	_
19	simply	simply	ADV	RB	_	_	_	_	_
20	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
21	function	function	NOUN	NN	Number=Sing	_	_	_	_
22	of	of	ADP	IN	_	_	_	_	_
23	its	its	PRON	PRP$	Gender=Neut|Number=Sing|Person=3|Poss=Yes|PronType=Prs	_	_	_	_
24	ability	ability	NOUN	NN	Number=Sing	_	_	_	_
25	to	to	PART	TO	_	_	_	_	_
26	modulate	modulate	VERB	VB	VerbForm=Inf	_	_	_	_
27	bHLH	bHLH	DET	DT	_	_	_	_	_
28	heterodimer	heterodimer	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
29	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
30	dependent	dependent	ADJ	JJ	Degree=Pos	_	_	_	_
31	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
32	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
33	and	and	CCONJ	CC	_	_	_	_	_
34	establish	establish	VERB	VB	VerbForm=Inf	_	_	_	_
35	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
36	biologically	biologically	ADV	RB	_	_	_	_	_
37	important	important	ADJ	JJ	Degree=Pos	_	_	_	_
38	mechanism	mechanism	NOUN	NN	Number=Sing	_	_	_	_
39	through	through	ADP	IN	_	_	_	_	_
40	which	which	PRON	WDT	PronType=Rel	_	_	_	_
41	Cdk2	Cdk2	NOUN	NN	Number=Sing	_	_	_	_
42	and	and	CCONJ	CC	_	_	_	_	_

# sent_id = 267
# text = Id-bHLH functions are integrated in the coordination of cell proliferation and differentiation.
1	Id	id	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
2	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
3	bHLH	bHLh	NOUN	NN	Number=Sing	_	_	_	_
4	functions	function	NOUN	NNS	Number=Plur	_	_	_	_
5	are	be	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
6	integrated	integrate	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
7	in	in	ADP	IN	_	_	_	_	_
8	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
9	coordination	coordination	NOUN	NN	Number=Sing	_	_	_	_
10	of	of	ADP	IN	_	_	_	_	_
11	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
12	proliferation	proliferation	NOUN	NN	Number=Sing	_	_	_	_
13	and	and	CCONJ	CC	_	_	_	_	_
14	differentiation	differentiation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
15	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 268
# text = Document 003002100 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	003002100	003002100	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 269
# text = Molecular and cellular analysis of human immunodeficiency virus-induced apoptosis in lymphoblastoid T-cell-line-expressing wild-type and mutated CD4 receptors.
1	Molecular	Molecular	ADJ	JJ	Degree=Pos	_	_	_	_
2	and	and	CCONJ	CC	_	_	_	_	_
3	cellular	cellular	ADJ	JJ	Degree=Pos	_	_	_	_
4	analysis	analysis	NOUN	NN	Number=Sing	_	_	_	_
5	of	of	ADP	IN	_	_	_	_	_
6	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
7	immunodeficiency	immunodeficiency	NOUN	NN	Number=Sing	_	_	_	_
8	virus	virus	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
9	-induced	-induce	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
10	apoptosis	apoptosis	NOUN	NN	Number=Sing	_	_	_	_
11	in	in	ADP	IN	_	_	_	_	_
12	lymphoblastoid	lymphoblastoid	ADJ	JJ	Degree=Pos	_	_	_	_
13	T-	t-	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
14	cell	cell	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
15	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
16	line	line	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
17	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
18	expressing	expresse	VERB	VBG	VerbForm=Ger	_	_	_	_
19	wild	wild	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
20	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
21	type	type	NOUN	NN	Number=Sing	_	_	_	_
22	and	and	CCONJ	CC	_	_	_	_	_
23	mutated	mutate	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
24	CD4	CD4	NUM	CD	NumType=Card	_	_	_	_
25	receptors	receptor	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
26	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 270
# text = We have previously shown that the presence of the CD4 cytoplasmic tail is critical for human immunodeficiency virus (HIV)-induced apoptosis (J.Corbeil, M.Tremblay, and D.D.Richman, J.Exp.Med.183:39-48, 1996).
1	We	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
2	have	have	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
3	previously	previously	ADV	RB	_	_	_	_	_
4	shown	show	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
5	that	that	SCONJ	IN	_	_	_	_	_
6	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
7	presence	presence	NOUN	NN	Number=Sing	_	_	_	_
8	of	of	ADP	IN	_	_	_	_	_
9	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
10	CD4	CD4	PROPN	NNP	Number=Sing	_	_	_	_
11	cytoplasmic	cytoplasmic	NOUN	NN	Number=Sing	_	_	_	_
12	tail	tail	NOUN	NN	Number=Sing	_	_	_	_
13	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
14	critical	critical	ADJ	JJ	Degree=Pos	_	_	_	_
15	for	for	ADP	IN	_	_	_	_	_
16	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
17	immunodeficiency	immunodeficiency	NOUN	NN	Number=Sing	_	_	_	_
18	virus	virus	NOUN	NN	Number=Sing	_	_	_	_
19	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
20	HIV	HIV	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
21	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
22	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
23	induced	induce	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
24	apoptosis	apoptosis	NOUN	NN	Number=Sing	_	_	_	_
25	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
26	J.Corbeil	J.Corbeil	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
27	,	,	PUNCT	,	_	_	_	_	_
28	M.Tremblay	M.Tremblay	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
29	,	,	PUNCT	,	_	_	_	_	_
30	and	and	CCONJ	CC	_	_	_	_	_
31	D.D.Richman	D.D.Richman	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
32	,	,	PUNCT	,	_	_	_	_	_
33	J.Exp.Med	J.Exp.Med	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
34	.183:39-48	.183:39-48	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
35	,	,	PUNCT	,	_	_	_	_	_
36	1996	1996	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
37	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
38	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 271
# text = We have pursued our investigation of the role of the CD4 transduction pathway in HIV-induced apoptosis.
1	We	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
2	have	have	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
3	pursued	pursue	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
4	our	we	PRON	PRP$	Number=Plur|Person=1|Poss=Yes|PronType=Prs	_	_	_	_
5	investigation	investigation	NOUN	NN	Number=Sing	_	_	_	_
6	of	of	ADP	IN	_	_	_	_	_
7	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
8	role	role	NOUN	NN	Number=Sing	_	_	_	_
9	of	of	ADP	IN	_	_	_	_	_
10	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
11	CD4	CD4	PROPN	NNP	Number=Sing	_	_	_	_
12	transduction	transduction	NOUN	NN	Number=Sing	_	_	_	_
13	pathway	pathway	NOUN	NN	Number=Sing	_	_	_	_
14	in	in	ADP	IN	_	_	_	_	_
15	HIV-	HIV-	SYM	NFP	_	_	_	_	SpaceAfter=No
16	induced	induce	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
17	apoptosis	apoptosis	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
18	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 272
# text = To do this, wild-type and mutant forms of the CD4 cytoplasmic tail were stably expressed in the lymphoblastoid T-cell line A2.01.
1	To	to	PART	TO	_	_	_	_	_
2	do	do	VERB	VB	VerbForm=Inf	_	_	_	_
3	this	this	PRON	DT	Number=Sing|PronType=Dem	_	_	_	SpaceAfter=No
4	,	,	PUNCT	,	_	_	_	_	_
5	wild	wild	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
6	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
7	type	type	NOUN	NN	Number=Sing	_	_	_	_
8	and	and	CCONJ	CC	_	_	_	_	_
9	mutant	mutant	ADJ	JJ	Degree=Pos	_	_	_	_
10	forms	form	NOUN	NNS	Number=Plur	_	_	_	_
11	of	of	ADP	IN	_	_	_	_	_
12	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
13	CD4	CD4	PROPN	NNP	Number=Sing	_	_	_	_
14	cytoplasmic	cytoplasmic	NOUN	NN	Number=Sing	_	_	_	_
15	tail	tail	NOUN	NN	Number=Sing	_	_	_	_
16	were	be	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
17	stably	stably	ADV	RB	_	_	_	_	_
18	expressed	express	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
19	in	in	ADP	IN	_	_	_	_	_
20	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
21	lymphoblastoid	lymphoblastoid	ADJ	JJ	Degree=Pos	_	_	_	_
22	T-	T-	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
23	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
24	line	line	NOUN	NN	Number=Sing	_	_	_	_
25	A2.01	a2.01	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
26	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 273
# text = Apoptosis was prevented when CD4 truncated at residue 402 was expressed; however, cells expressing mutated receptors that do not associate with p56(lck) (mutated at the dicysteine motif and truncated at residue 418) but which conserved proximal domains of the cytoplasmic tail underwent apoptosis like wild- type CD4.
1	Apoptosis	Apoptosis	PRON	DT	Number=Sing|PronType=Dem	_	_	_	_
2	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
3	prevented	prevent	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
4	when	when	ADV	WRB	PronType=Int	_	_	_	_
5	CD4	CD4	NUM	CD	NumType=Card	_	_	_	_
6	truncated	truncate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
7	at	at	ADP	IN	_	_	_	_	_
8	residue	residue	NOUN	NN	Number=Sing	_	_	_	_
9	402	402	NUM	CD	NumType=Card	_	_	_	_
10	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
11	expressed	express	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	SpaceAfter=No
12	;	;	PUNCT	,	_	_	_	_	_
13	however	however	ADV	RB	_	_	_	_	SpaceAfter=No
14	,	,	PUNCT	,	_	_	_	_	_
15	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
16	expressing	expresse	VERB	VBG	VerbForm=Ger	_	_	_	_
17	mutated	mutate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
18	receptors	receptor	NOUN	NNS	Number=Plur	_	_	_	_
19	that	that	PRON	WDT	PronType=Rel	_	_	_	_
20	do	do	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
21	not	not	PART	RB	_	_	_	_	_
22	associate	associate	VERB	VB	VerbForm=Inf	_	_	_	_
23	with	with	ADP	IN	_	_	_	_	_
24	p56	p56	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
25	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
26	lck	lck	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
27	)	)	PUNCT	-RRB-	_	_	_	_	_
28	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
29	mutated	mutate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
30	at	at	ADP	IN	_	_	_	_	_
31	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
32	dicysteine	dicysteine	NOUN	NN	Number=Sing	_	_	_	_
33	motif	motif	NOUN	NN	Number=Sing	_	_	_	_
34	and	and	CCONJ	CC	_	_	_	_	_
35	truncated	truncate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
36	at	at	ADP	IN	_	_	_	_	_
37	residue	residue	NOUN	NN	Number=Sing	_	_	_	_
38	418	418	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
39	)	)	PUNCT	-RRB-	_	_	_	_	_
40	but	but	CCONJ	CC	_	_	_	_	_
41	which	which	PRON	WDT	PronType=Int	_	_	_	_
42	conserved	conserve	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
43	proximal	proximal	ADJ	JJ	Degree=Pos	_	_	_	_
44	domains	domains	NOUN	NNS	Number=Plur	_	_	_	_
45	of	of	ADP	IN	_	_	_	_	_
46	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
47	cytoplasmic	cytoplasmic	ADJ	JJ	Degree=Pos	_	_	_	_
48	tail	tail	NOUN	NN	Number=Sing	_	_	_	_
49	underwent	underwent	ADJ	JJ	Degree=Pos	_	_	_	_
50	apoptosis	apoptosis	NOUN	NN	Number=Sing	_	_	_	_
51	like	like	ADP	IN	_	_	_	_	_
52	wild	wild	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
53	-	-	PUNCT	HYPH	_	_	_	_	_
54	type	type	NOUN	NN	Number=Sing	_	_	_	_
55	CD4	Cd4	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
56	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 274
# text = The differences between wild-type and mutated receptors in the induction of apoptosis were not related to levels of p56(lck) or NF- kappaB activation.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	differences	difference	NOUN	NNS	Number=Plur	_	_	_	_
3	between	between	ADP	IN	_	_	_	_	_
4	wild	wild	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
5	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
6	type	type	NOUN	NN	Number=Sing	_	_	_	_
7	and	and	CCONJ	CC	_	_	_	_	_
8	mutated	mutate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
9	receptors	receptor	NOUN	NNS	Number=Plur	_	_	_	_
10	in	in	ADP	IN	_	_	_	_	_
11	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
12	induction	induction	NOUN	NN	Number=Sing	_	_	_	_
13	of	of	ADP	IN	_	_	_	_	_
14	apoptosis	apoptosis	PRON	DT	Number=Sing|PronType=Dem	_	_	_	_
15	were	be	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
16	not	not	PART	RB	_	_	_	_	_
17	related	related	ADJ	JJ	Degree=Pos	_	_	_	_
18	to	to	ADP	IN	_	_	_	_	_
19	levels	level	NOUN	NNS	Number=Plur	_	_	_	_
20	of	of	ADP	IN	_	_	_	_	_
21	p56	p56	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
22	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
23	lck	lck	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
24	)	)	PUNCT	-RRB-	_	_	_	_	_
25	or	or	CCONJ	CC	_	_	_	_	_
26	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
27	-	-	PUNCT	HYPH	_	_	_	_	_
28	kappaB	kappaB	PROPN	NNP	Number=Sing	_	_	_	_
29	activation	activation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
30	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 275
# text = Initial signaling through the CD4 receptor played a major role in the sensitization of HIV-infected T cells to undergo apoptosis.
1	Initial	initial	ADJ	JJ	Degree=Pos	_	_	_	_
2	signaling	signaling	NOUN	NN	Number=Sing	_	_	_	_
3	through	through	ADP	IN	_	_	_	_	_
4	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
5	CD4	CD4	PROPN	NNP	Number=Sing	_	_	_	_
6	receptor	receptor	NOUN	NN	Number=Sing	_	_	_	_
7	played	play	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
8	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
9	major	major	ADJ	JJ	Degree=Pos	_	_	_	_
10	role	role	NOUN	NN	Number=Sing	_	_	_	_
11	in	in	ADP	IN	_	_	_	_	_
12	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
13	sensitization	sensitization	NOUN	NN	Number=Sing	_	_	_	_
14	of	of	ADP	IN	_	_	_	_	_
15	HIV-	HIV-	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
16	infected	infect	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
17	T	t	PROPN	NNP	Number=Sing	_	_	_	_
18	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
19	to	to	PART	TO	_	_	_	_	_
20	undergo	undergo	VERB	VB	VerbForm=Inf	_	_	_	_
21	apoptosis	apoptosis	PRON	DT	Number=Sing|PronType=Dem	_	_	_	SpaceAfter=No
22	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 276
# text = Incubation of HIV-infected cells with monoclonal antibody (MAb) 13B8-2, which binds to CD4 in a region critical for dimerization of the receptor, prevented apoptosis without inhibiting HIV replication.
1	Incubation	incubation	NOUN	NN	Number=Sing	_	_	_	_
2	of	of	ADP	IN	_	_	_	_	_
3	HIV-	HIV-	PUNCT	:	_	_	_	_	SpaceAfter=No
4	infected	infect	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
5	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
6	with	with	ADP	IN	_	_	_	_	_
7	monoclonal	monoclonal	ADJ	JJ	Degree=Pos	_	_	_	_
8	antibody	antibody	NOUN	NN	Number=Sing	_	_	_	_
9	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
10	MAb	MAb	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
11	)	)	PUNCT	-RRB-	_	_	_	_	_
12	13B8	13B8	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
13	-	-	SYM	SYM	_	_	_	_	SpaceAfter=No
14	2	2	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
15	,	,	PUNCT	,	_	_	_	_	_
16	which	which	PRON	WDT	PronType=Rel	_	_	_	_
17	binds	bind	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
18	to	to	ADP	IN	_	_	_	_	_
19	CD4	CD4	PROPN	NNP	Number=Sing	_	_	_	_
20	in	in	ADP	IN	_	_	_	_	_
21	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
22	region	region	NOUN	NN	Number=Sing	_	_	_	_
23	critical	critical	ADJ	JJ	Degree=Pos	_	_	_	_
24	for	for	ADP	IN	_	_	_	_	_
25	dimerization	dimerization	NOUN	NN	Number=Sing	_	_	_	_
26	of	of	ADP	IN	_	_	_	_	_
27	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
28	receptor	receptor	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
29	,	,	PUNCT	,	_	_	_	_	_
30	prevented	prevent	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
31	apoptosis	apoptosis	NOUN	NN	Number=Sing	_	_	_	_
32	without	without	SCONJ	IN	_	_	_	_	_
33	inhibiting	inhibit	VERB	VBG	VerbForm=Ger	_	_	_	_
34	HIV	HIV	PROPN	NNP	Number=Sing	_	_	_	_
35	replication	replication	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
36	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 277
# text = Moreover, the apoptotic process was not related to Fas-Fas ligand interaction; however, an antagonistic anti-Fas MAb (ZB-4) enhanced apoptosis in HIV-infected cells without inducing apoptosis in uninfected cells.
1	Moreover	moreover	ADV	RB	_	_	_	_	SpaceAfter=No
2	,	,	PUNCT	,	_	_	_	_	_
3	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
4	apoptotic	apoptotic	ADJ	JJ	Degree=Pos	_	_	_	_
5	process	process	NOUN	NN	Number=Sing	_	_	_	_
6	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
7	not	not	PART	RB	_	_	_	_	_
8	related	related	ADJ	JJ	Degree=Pos	_	_	_	_
9	to	to	ADP	IN	_	_	_	_	_
10	Fas	Fas	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
11	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
12	Fas	Fas	PROPN	NNP	Number=Sing	_	_	_	_
13	ligand	ligand	NOUN	NN	Number=Sing	_	_	_	_
14	interaction	interaction	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
15	;	;	PUNCT	,	_	_	_	_	_
16	however	however	ADV	RB	_	_	_	_	SpaceAfter=No
17	,	,	PUNCT	,	_	_	_	_	_
18	an	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
19	antagonistic	antagonistic	ADJ	JJ	Degree=Pos	_	_	_	_
20	anti-Fas	anti-Fas	PROPN	NNPS	Number=Plur	_	_	_	_
21	MAb	MAb	PROPN	NNP	Number=Sing	_	_	_	_
22	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
23	ZB	ZB	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
24	-	-	SYM	SYM	_	_	_	_	SpaceAfter=No
25	4	4	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
26	)	)	PUNCT	-RRB-	_	_	_	_	_
27	enhanced	enhance	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
28	apoptosis	apoptosis	NOUN	NN	Number=Sing	_	_	_	_
29	in	in	ADP	IN	_	_	_	_	_
30	HIV-	HIV-	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
31	infected	infect	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
32	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
33	without	without	SCONJ	IN	_	_	_	_	_
34	inducing	induce	VERB	VBG	VerbForm=Ger	_	_	_	_
35	apoptosis	apoptosis	NOUN	NN	Number=Sing	_	_	_	_
36	in	in	ADP	IN	_	_	_	_	_
37	uninfected	uninfected	ADJ	JJ	Degree=Pos	_	_	_	_
38	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
39	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 278
# text = These observations demonstrate that CD4 signaling mediates HIV-induced apoptosis by a mechanism independent of Fas-Fas ligand interaction, does not require p56(lck) signaling, and may involve a critical region for CD4 dimerization.
1	These	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
2	observations	observation	NOUN	NNS	Number=Plur	_	_	_	_
3	demonstrate	demonstrate	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
4	that	that	SCONJ	IN	_	_	_	_	_
5	CD4	CD4	PROPN	NNP	Number=Sing	_	_	_	_
6	signaling	signal	VERB	VBG	VerbForm=Ger	_	_	_	_
7	mediates	mediate	NOUN	NNS	Number=Plur	_	_	_	_
8	HIV-	HIV-	PUNCT	,	_	_	_	_	SpaceAfter=No
9	induced	induce	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
10	apoptosis	apoptosis	NOUN	NN	Number=Sing	_	_	_	_
11	by	by	ADP	IN	_	_	_	_	_
12	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
13	mechanism	mechanism	NOUN	NN	Number=Sing	_	_	_	_
14	independent	independent	ADJ	JJ	Degree=Pos	_	_	_	_
15	of	of	ADP	IN	_	_	_	_	_
16	Fas	Fas	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
17	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
18	Fas	Fas	PROPN	NNP	Number=Sing	_	_	_	_
19	ligand	ligand	NOUN	NN	Number=Sing	_	_	_	_
20	interaction	interaction	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
21	,	,	PUNCT	,	_	_	_	_	_
22	does	do	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
23	not	not	PART	RB	_	_	_	_	_
24	require	require	VERB	VB	VerbForm=Inf	_	_	_	_
25	p56	p56	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
26	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
27	lck	lck	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
28	)	)	PUNCT	-RRB-	_	_	_	_	_
29	signaling	signal	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
30	,	,	PUNCT	,	_	_	_	_	_
31	and	and	CCONJ	CC	_	_	_	_	_
32	may	may	AUX	MD	VerbForm=Fin	_	_	_	_
33	involve	involve	VERB	VB	VerbForm=Inf	_	_	_	_
34	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
35	critical	critical	ADJ	JJ	Degree=Pos	_	_	_	_
36	region	region	NOUN	NN	Number=Sing	_	_	_	_
37	for	for	ADP	IN	_	_	_	_	_
38	CD4	CD4	NUM	CD	NumType=Card	_	_	_	_
39	dimerization	dimerization	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
40	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 279
# text = Document 003002101 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	003002101	003002101	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 280
# text = Characterization of the human elk-1 promoter.
1	Characterization	Characterization	NOUN	NN	Number=Sing	_	_	_	_
2	of	of	ADP	IN	_	_	_	_	_
3	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
4	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
5	elk	elk	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
6	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
7	1	1	NUM	CD	NumType=Card	_	_	_	_
8	promoter	promoter	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
9	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 281
# text = Potential role of a downstream intronic sequence for elk-1 gene expression in monocytes.
1	Potential	potential	ADJ	JJ	Degree=Pos	_	_	_	_
2	role	role	NOUN	NN	Number=Sing	_	_	_	_
3	of	of	ADP	IN	_	_	_	_	_
4	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
5	downstream	downstream	ADJ	JJ	Degree=Pos	_	_	_	_
6	intronic	intronic	ADJ	JJ	Degree=Pos	_	_	_	_
7	sequence	sequence	NOUN	NN	Number=Sing	_	_	_	_
8	for	for	ADP	IN	_	_	_	_	_
9	elk	elk	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
10	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
11	1	1	NUM	CD	NumType=Card	_	_	_	_
12	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
13	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
14	in	in	ADP	IN	_	_	_	_	_
15	monocytes	monocyte	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
16	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 282
# text = To characterize the human elk-1 promoter, we mapped the transcriptional start site and isolated elk-1-specific genomic phage clones that contained extensive upstream and downstream sequences.
1	To	to	PART	TO	_	_	_	_	_
2	characterize	characterize	VERB	VB	VerbForm=Inf	_	_	_	_
3	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
4	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
5	elk	elk	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
6	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
7	1	1	NUM	CD	NumType=Card	_	_	_	_
8	promoter	promoter	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
9	,	,	PUNCT	,	_	_	_	_	_
10	we	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
11	mapped	map	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
12	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
13	transcriptional	transcriptional	ADJ	JJ	Degree=Pos	_	_	_	_
14	start	start	NOUN	NN	Number=Sing	_	_	_	_
15	site	site	NOUN	NN	Number=Sing	_	_	_	_
16	and	and	CCONJ	CC	_	_	_	_	_
17	isolated	isolate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
18	elk	elk	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
19	-1	-1	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
20	-	-	SYM	SYM	_	_	_	_	SpaceAfter=No
21	specific	specific	ADJ	JJ	Degree=Pos	_	_	_	_
22	genomic	genomic	ADJ	JJ	Degree=Pos	_	_	_	_
23	phage	phage	NOUN	NN	Number=Sing	_	_	_	_
24	clones	clone	NOUN	NNS	Number=Plur	_	_	_	_
25	that	that	PRON	WDT	PronType=Rel	_	_	_	_
26	contained	contain	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
27	extensive	extensive	ADJ	JJ	Degree=Pos	_	_	_	_
28	upstream	upstream	NOUN	NN	Number=Sing	_	_	_	_
29	and	and	CCONJ	CC	_	_	_	_	_
30	downstream	downstream	ADJ	JJ	Degree=Pos	_	_	_	_
31	sequences	sequence	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
32	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 283
# text = A TATA-like motif was identified immediately upstream of the transcriptional start site.
1	A	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
2	TATA	TATA	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
3	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
4	like	like	ADJ	JJ	Degree=Pos	_	_	_	_
5	motif	motif	NOUN	NN	Number=Sing	_	_	_	_
6	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
7	identified	identify	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
8	immediately	immediately	ADV	RB	_	_	_	_	_
9	upstream	upstream	NOUN	NN	Number=Sing	_	_	_	_
10	of	of	ADP	IN	_	_	_	_	_
11	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
12	transcriptional	transcriptional	ADJ	JJ	Degree=Pos	_	_	_	_
13	start	start	NOUN	NN	Number=Sing	_	_	_	_
14	site	site	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
15	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 284
# text = Functional analyses of DNA fragments containing the TATA element and the identification of a DNase I-hypersensitive chromatin site (HS 1) in close proximity to the TATA box suggest that the identified TATA motif is important for elk-1 transcription in vivo.
1	Functional	functional	ADJ	JJ	Degree=Pos	_	_	_	_
2	analyses	analysis	NOUN	NNS	Number=Plur	_	_	_	_
3	of	of	ADP	IN	_	_	_	_	_
4	DNA	dna	NOUN	NN	Number=Sing	_	_	_	_
5	fragments	fragment	NOUN	NNS	Number=Plur	_	_	_	_
6	containing	contain	VERB	VBG	VerbForm=Ger	_	_	_	_
7	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
8	TATA	TATa	NOUN	NN	Number=Sing	_	_	_	_
9	element	element	NOUN	NN	Number=Sing	_	_	_	_
10	and	and	CCONJ	CC	_	_	_	_	_
11	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
12	identification	identification	NOUN	NN	Number=Sing	_	_	_	_
13	of	of	ADP	IN	_	_	_	_	_
14	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
15	DNase	DNase	NOUN	NN	Number=Sing	_	_	_	_
16	I	I	PRON	PRP	Case=Nom|Number=Sing|Person=1|PronType=Prs	_	_	_	SpaceAfter=No
17	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
18	hypersensitive	hypersensitive	ADJ	JJ	Degree=Pos	_	_	_	_
19	chromatin	chromatin	NOUN	NN	Number=Sing	_	_	_	_
20	site	site	NOUN	NN	Number=Sing	_	_	_	_
21	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
22	HS	h	PROPN	NNP	Number=Sing	_	_	_	_
23	1	1	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
24	)	)	PUNCT	-RRB-	_	_	_	_	_
25	in	in	ADP	IN	_	_	_	_	_
26	close	close	ADJ	JJ	Degree=Pos	_	_	_	_
27	proximity	proximity	NOUN	NN	Number=Sing	_	_	_	_
28	to	to	ADP	IN	_	_	_	_	_
29	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
30	TATA	TATa	PROPN	NNP	Number=Sing	_	_	_	_
31	box	box	NOUN	NN	Number=Sing	_	_	_	_
32	suggest	suggest	VERB	VB	VerbForm=Inf	_	_	_	_
33	that	that	SCONJ	IN	_	_	_	_	_
34	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
35	identified	identified	ADJ	JJ	Degree=Pos	_	_	_	_
36	TATA	TATa	NOUN	NN	Number=Sing	_	_	_	_
37	motif	motif	NOUN	NN	Number=Sing	_	_	_	_
38	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
39	important	important	ADJ	JJ	Degree=Pos	_	_	_	_
40	for	for	ADP	IN	_	_	_	_	_
41	elk	elk	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
42	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
43	1	1	NUM	CD	NumType=Card	_	_	_	_
44	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
45	in	in	ADP	IN	_	_	_	_	_
46	vivo.	vivo.	NOUN	NN	Number=Sing	_	_	_	_

# sent_id = 285
# text = Sequences upstream and downstream from the TATA box were found to contribute to elk-1 promoter activity.
1	Sequences	Sequences	NOUN	NNS	Number=Plur	_	_	_	_
2	upstream	upstream	ADJ	JJ	Degree=Pos	_	_	_	_
3	and	and	CCONJ	CC	_	_	_	_	_
4	downstream	downstream	ADJ	JJ	Degree=Pos	_	_	_	_
5	from	from	ADP	IN	_	_	_	_	_
6	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
7	TATA	TATa	PROPN	NNP	Number=Sing	_	_	_	_
8	box	box	NOUN	NN	Number=Sing	_	_	_	_
9	were	be	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
10	found	find	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
11	to	to	PART	TO	_	_	_	_	_
12	contribute	contribute	VERB	VB	VerbForm=Inf	_	_	_	_
13	to	to	PART	TO	_	_	_	_	_
14	elk	elk	VERB	VB	VerbForm=Inf	_	_	_	SpaceAfter=No
15	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
16	1	1	NUM	CD	NumType=Card	_	_	_	_
17	promoter	promoter	NOUN	NN	Number=Sing	_	_	_	_
18	activity	activity	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
19	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 286
# text = A second hypersensitive site (HS 2) was identified within the first intron in pre-monocytic cells, which express Elk-1 only when differentiating to monocytes.
1	A	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
2	second	second	ADJ	JJ	Degree=Pos|NumType=Ord	_	_	_	_
3	hypersensitive	hypersensitive	ADJ	JJ	Degree=Pos	_	_	_	_
4	site	site	NOUN	NN	Number=Sing	_	_	_	_
5	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
6	HS	HS	NOUN	NN	Number=Sing	_	_	_	_
7	2	2	X	LS	_	_	_	_	SpaceAfter=No
8	)	)	PUNCT	-RRB-	_	_	_	_	_
9	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
10	identified	identify	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
11	within	within	ADP	IN	_	_	_	_	_
12	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
13	first	first	ADJ	JJ	Degree=Pos|NumType=Ord	_	_	_	_
14	intron	intron	NOUN	NN	Number=Sing	_	_	_	_
15	in	in	ADP	IN	_	_	_	_	_
16	pre-monocytic	pre-monocytic	ADJ	JJ	Degree=Pos	_	_	_	_
17	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
18	,	,	PUNCT	,	_	_	_	_	_
19	which	which	PRON	WDT	PronType=Rel	_	_	_	_
20	express	express	ADJ	JJ	Degree=Pos	_	_	_	_
21	Elk	elk	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
22	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
23	1	1	NUM	CD	NumType=Card	_	_	_	_
24	only	only	ADV	RB	_	_	_	_	_
25	when	when	ADV	WRB	PronType=Int	_	_	_	_
26	differentiating	differentiat	VERB	VBG	VerbForm=Ger	_	_	_	_
27	to	to	ADP	IN	_	_	_	_	_
28	monocytes	monocyte	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
29	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 287
# text = In a variety of other cell types, which display a constitutive Elk-1 expression, HS 2 did not exist, suggesting that inducibility of elk-1 expression is associated with the presence of HS 2. Egr-1 and the serum response factor were found to interact specifically with the intronic sequence at +265 and +448, respectively.
1	In	in	ADP	IN	_	_	_	_	_
2	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
3	variety	variety	NOUN	NN	Number=Sing	_	_	_	_
4	of	of	ADP	IN	_	_	_	_	_
5	other	other	ADJ	JJ	Degree=Pos	_	_	_	_
6	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
7	types	type	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
8	,	,	PUNCT	,	_	_	_	_	_
9	which	which	PRON	WDT	PronType=Rel	_	_	_	_
10	display	display	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
11	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
12	constitutive	constitutive	ADJ	JJ	Degree=Pos	_	_	_	_
13	Elk	elk	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
14	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
15	1	1	NUM	CD	NumType=Card	_	_	_	_
16	expression	expression	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
17	,	,	PUNCT	,	_	_	_	_	_
18	HS	HS	PROPN	NNP	Number=Sing	_	_	_	_
19	2	2	NUM	CD	NumType=Card	_	_	_	_
20	did	do	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
21	not	not	PART	RB	_	_	_	_	_
22	exist	exist	VERB	VB	VerbForm=Inf	_	_	_	SpaceAfter=No
23	,	,	PUNCT	,	_	_	_	_	_
24	suggesting	suggest	VERB	VBG	VerbForm=Ger	_	_	_	_
25	that	that	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
26	inducibility	inducibility	NOUN	NN	Number=Sing	_	_	_	_
27	of	of	ADP	IN	_	_	_	_	_
28	elk	elk	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
29	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
30	1	1	NUM	CD	NumType=Card	_	_	_	_
31	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
32	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
33	associated	associate	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
34	with	with	ADP	IN	_	_	_	_	_
35	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
36	presence	presence	NOUN	NN	Number=Sing	_	_	_	_
37	of	of	ADP	IN	_	_	_	_	_
38	HS	HS	PROPN	NNP	Number=Sing	_	_	_	_
39	2	2	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
40	.	.	PUNCT	.	_	_	_	_	_
41	Egr	Egr	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
42	-1	-1	NUM	CD	NumType=Card	_	_	_	_
43	and	and	CCONJ	CC	_	_	_	_	_
44	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
45	serum	serum	NOUN	NN	Number=Sing	_	_	_	_
46	response	response	NOUN	NN	Number=Sing	_	_	_	_
47	factor	factor	NOUN	NN	Number=Sing	_	_	_	_
48	were	be	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
49	found	find	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
50	to	to	PART	TO	_	_	_	_	_
51	interact	interact	VERB	VB	VerbForm=Inf	_	_	_	_
52	specifically	specifically	ADV	RB	_	_	_	_	_
53	with	with	ADP	IN	_	_	_	_	_
54	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
55	intronic	intronic	ADJ	JJ	Degree=Pos	_	_	_	_
56	sequence	sequence	NOUN	NN	Number=Sing	_	_	_	_
57	at	at	ADP	IN	_	_	_	_	_
58	+	+	SYM	SYM	_	_	_	_	SpaceAfter=No
59	265	265	NUM	CD	NumType=Card	_	_	_	_
60	and	and	CCONJ	CC	_	_	_	_	_
61	+	+	SYM	SYM	_	_	_	_	SpaceAfter=No
62	448	448	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
63	,	,	PUNCT	,	_	_	_	_	_
64	respectively	respectively	ADV	RB	_	_	_	_	SpaceAfter=No
65	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 288
# text = Because Egr-1 mRNA and protein levels were observed to increase significantly before induction of elk-1 expression, we propose that Egr-1 is important for the regulation of elk-1 transcription in differentiating monocytes.
1	Because	because	SCONJ	IN	_	_	_	_	_
2	Egr	Egr	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
3	-1	-1	NUM	CD	NumType=Card	_	_	_	_
4	mRNA	mRNa	NOUN	NN	Number=Sing	_	_	_	_
5	and	and	CCONJ	CC	_	_	_	_	_
6	protein	protein	NOUN	NN	Number=Sing	_	_	_	_
7	levels	level	NOUN	NNS	Number=Plur	_	_	_	_
8	were	be	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
9	observed	observe	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
10	to	to	PART	TO	_	_	_	_	_
11	increase	increase	VERB	VB	VerbForm=Inf	_	_	_	_
12	significantly	significantly	ADV	RB	_	_	_	_	_
13	before	before	ADP	IN	_	_	_	_	_
14	induction	induction	NOUN	NN	Number=Sing	_	_	_	_
15	of	of	ADP	IN	_	_	_	_	_
16	elk	elk	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
17	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
18	1	1	NUM	CD	NumType=Card	_	_	_	_
19	expression	expression	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
20	,	,	PUNCT	,	_	_	_	_	_
21	we	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
22	propose	propose	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
23	that	that	SCONJ	IN	_	_	_	_	_
24	Egr	Egr	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
25	-1	-1	NUM	CD	NumType=Card	_	_	_	_
26	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
27	important	important	ADJ	JJ	Degree=Pos	_	_	_	_
28	for	for	ADP	IN	_	_	_	_	_
29	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
30	regulation	regulation	NOUN	NN	Number=Sing	_	_	_	_
31	of	of	ADP	IN	_	_	_	_	_
32	elk	elk	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
33	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
34	1	1	NUM	CD	NumType=Card	_	_	_	_
35	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
36	in	in	ADP	IN	_	_	_	_	_
37	differentiating	differentiat	ADJ	JJ	Degree=Pos	_	_	_	_
38	monocytes	monocyte	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
39	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 289
# text = Document 003002102 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	003002102	003002102	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 290
# text = Induction of cytokine expression in leukocytes by binding of thrombin-stimulated platelets.
1	Induction	Induction	NOUN	NN	Number=Sing	_	_	_	_
2	of	of	ADP	IN	_	_	_	_	_
3	cytokine	cytokine	NOUN	NN	Number=Sing	_	_	_	_
4	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
5	in	in	ADP	IN	_	_	_	_	_
6	leukocytes	leukocyte	NOUN	NNS	Number=Plur	_	_	_	_
7	by	by	SCONJ	IN	_	_	_	_	_
8	binding	binding	VERB	VBG	VerbForm=Ger	_	_	_	_
9	of	of	ADP	IN	_	_	_	_	_
10	thrombin-	thrombin-	SYM	NFP	_	_	_	_	SpaceAfter=No
11	stimulated	stimulate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
12	platelets	platelet	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
13	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 291
# text = BACKGROUND: Activated platelets tether and activate myeloid leukocytes.
1	BACKGROUND	background	ADP	IN	_	_	_	_	SpaceAfter=No
2	:	:	PUNCT	:	_	_	_	_	_
3	Activated	activate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
4	platelets	platelet	NOUN	NNS	Number=Plur	_	_	_	_
5	tether	tether	NOUN	NN	Number=Sing	_	_	_	_
6	and	and	CCONJ	CC	_	_	_	_	_
7	activate	activate	ADJ	JJ	Degree=Pos	_	_	_	_
8	myeloid	myeloid	ADJ	JJ	Degree=Pos	_	_	_	_
9	leukocytes	leukocyte	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
10	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 292
# text = To investigate the potential relevance of this mechanism in acute myocardial infarction (AMI), we examined cytokine induction by leukocyte-platelet adhesion and the occurrence of leukocyte-platelet conjugates in patients with AMI.
1	To	to	PART	TO	_	_	_	_	_
2	investigate	investigate	VERB	VB	VerbForm=Inf	_	_	_	_
3	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
4	potential	potential	ADJ	JJ	Degree=Pos	_	_	_	_
5	relevance	relevance	NOUN	NN	Number=Sing	_	_	_	_
6	of	of	ADP	IN	_	_	_	_	_
7	this	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
8	mechanism	mechanism	NOUN	NN	Number=Sing	_	_	_	_
9	in	in	ADP	IN	_	_	_	_	_
10	acute	acute	ADJ	JJ	Degree=Pos	_	_	_	_
11	myocardial	myocardial	ADJ	JJ	Degree=Pos	_	_	_	_
12	infarction	infarction	NOUN	NN	Number=Sing	_	_	_	_
13	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
14	AMI	Ami	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
15	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
16	,	,	PUNCT	,	_	_	_	_	_
17	we	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
18	examined	examin	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
19	cytokine	cytokine	NOUN	NN	Number=Sing	_	_	_	_
20	induction	induction	NOUN	NN	Number=Sing	_	_	_	_
21	by	by	ADP	IN	_	_	_	_	_
22	leukocyte	leukocyte	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
23	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
24	platelet	platelet	NOUN	NN	Number=Sing	_	_	_	_
25	adhesion	adhesion	NOUN	NN	Number=Sing	_	_	_	_
26	and	and	CCONJ	CC	_	_	_	_	_
27	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
28	occurrence	occurrence	NOUN	NN	Number=Sing	_	_	_	_
29	of	of	ADP	IN	_	_	_	_	_
30	leukocyte	leukocyte	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
31	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
32	platelet	platelet	NOUN	NN	Number=Sing	_	_	_	_
33	conjugates	conjugate	NOUN	NNS	Number=Plur	_	_	_	_
34	in	in	ADP	IN	_	_	_	_	_
35	patients	patient	NOUN	NNS	Number=Plur	_	_	_	_
36	with	with	ADP	IN	_	_	_	_	_
37	AMI	AMI	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
38	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 293
# text = METHODS AND RESULTS:
1	METHODS	method	NOUN	NNS	Number=Plur	_	_	_	_
2	AND	and	CCONJ	CC	_	_	_	_	_
3	RESULTS	result	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	:	:	PUNCT	:	_	_	_	_	_

# sent_id = 294
# text = We obtained peripheral venous blood samples in 20 patients with AMI before and daily for 5 days after direct percutaneous transluminal coronary angioplasty (PTCA) and in 20 patients undergoing elective PTCA.
1	We	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
2	obtained	obtain	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
3	peripheral	peripheral	ADJ	JJ	Degree=Pos	_	_	_	_
4	venous	venous	ADJ	JJ	Degree=Pos	_	_	_	_
5	blood	blood	NOUN	NN	Number=Sing	_	_	_	_
6	samples	sample	NOUN	NNS	Number=Plur	_	_	_	_
7	in	in	ADP	IN	_	_	_	_	_
8	20	20	NUM	CD	NumType=Card	_	_	_	_
9	patients	patient	NOUN	NNS	Number=Plur	_	_	_	_
10	with	with	ADP	IN	_	_	_	_	_
11	AMI	AMI	PROPN	NNP	Number=Sing	_	_	_	_
12	before	before	ADV	RB	_	_	_	_	_
13	and	and	CCONJ	CC	_	_	_	_	_
14	daily	daily	ADV	RB	_	_	_	_	_
15	for	for	ADP	IN	_	_	_	_	_
16	5	5	NUM	CD	NumType=Card	_	_	_	_
17	days	day	NOUN	NNS	Number=Plur	_	_	_	_
18	after	after	ADP	IN	_	_	_	_	_
19	direct	direct	ADJ	JJ	Degree=Pos	_	_	_	_
20	percutaneous	percutaneous	ADJ	JJ	Degree=Pos	_	_	_	_
21	transluminal	transluminal	ADJ	JJ	Degree=Pos	_	_	_	_
22	coronary	coronary	NOUN	NN	Number=Sing	_	_	_	_
23	angioplasty	angioplasty	NOUN	NN	Number=Sing	_	_	_	_
24	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
25	PTCA	PTCA	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
26	)	)	PUNCT	-RRB-	_	_	_	_	_
27	and	and	CCONJ	CC	_	_	_	_	_
28	in	in	ADP	IN	_	_	_	_	_
29	20	20	NUM	CD	NumType=Card	_	_	_	_
30	patients	patient	NOUN	NNS	Number=Plur	_	_	_	_
31	undergoing	undergo	VERB	VBG	VerbForm=Ger	_	_	_	_
32	elective	elective	ADJ	JJ	Degree=Pos	_	_	_	_
33	PTCA	PTCa	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
34	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 295
# text = Throughout the study period, CD41 immunofluorescence of leukocytes (flow cytometry) revealed increased leukocyte-platelet adhesion in patients with AMI compared with control patients (mean +/- SE of fluorescence [channels] before PTCA: 77 +/- 16 versus 35 +/- 9; P = .003).
1	Throughout	throughout	ADP	IN	_	_	_	_	_
2	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
3	study	study	NOUN	NN	Number=Sing	_	_	_	_
4	period	period	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
5	,	,	PUNCT	,	_	_	_	_	_
6	CD41	CD41	NUM	CD	NumType=Card	_	_	_	_
7	immunofluorescence	immunofluorescence	NOUN	NN	Number=Sing	_	_	_	_
8	of	of	ADP	IN	_	_	_	_	_
9	leukocytes	leukocyte	NOUN	NNS	Number=Plur	_	_	_	_
10	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
11	flow	flow	NOUN	NN	Number=Sing	_	_	_	_
12	cytometry	cytometry	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
13	)	)	PUNCT	-RRB-	_	_	_	_	_
14	revealed	reveal	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
15	increased	increase	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
16	leukocyte	leukocyte	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
17	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
18	platelet	platelet	NOUN	NN	Number=Sing	_	_	_	_
19	adhesion	adhesion	NOUN	NN	Number=Sing	_	_	_	_
20	in	in	ADP	IN	_	_	_	_	_
21	patients	patient	NOUN	NNS	Number=Plur	_	_	_	_
22	with	with	ADP	IN	_	_	_	_	_
23	AMI	AMI	PROPN	NNP	Number=Sing	_	_	_	_
24	compared	compare	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
25	with	with	ADP	IN	_	_	_	_	_
26	control	control	NOUN	NN	Number=Sing	_	_	_	_
27	patients	patient	NOUN	NNS	Number=Plur	_	_	_	_
28	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
29	mean	mean	X	GW	_	_	_	_	_
30	+/-	+/-	X	GW	_	_	_	_	_
31	SE	se	NOUN	NN	Number=Sing	_	_	_	_
32	of	of	ADP	IN	_	_	_	_	_
33	fluorescence	fluorescence	NOUN	NN	Number=Sing	_	_	_	_
34	[	[	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
35	channels	channel	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
36	]	]	PUNCT	-RRB-	_	_	_	_	_
37	before	before	ADP	IN	_	_	_	_	_
38	PTCA	PTCa	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
39	:	:	PUNCT	:	_	_	_	_	_
40	77	77	NUM	CD	NumType=Card	_	_	_	_
41	+/-	+/-	SYM	SYM	_	_	_	_	_
42	16	16	NUM	CD	NumType=Card	_	_	_	_
43	versus	versus	ADP	IN	_	_	_	_	_
44	35	35	NUM	CD	NumType=Card	_	_	_	_
45	+/-	+/-	SYM	SYM	_	_	_	_	_
46	9	9	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
47	;	;	PUNCT	,	_	_	_	_	_
48	P	p	NOUN	NN	Number=Sing	_	_	_	_
49	=	=	SYM	SYM	_	_	_	_	_
50	.003	.003	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
51	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
52	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 296
# text = In vitro, thrombin-stimulated fixed platelets bound to neutrophils and monocytes.
1	In	in	ADP	IN	_	_	_	_	_
2	vitro	vitro	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
3	,	,	PUNCT	,	_	_	_	_	_
4	thrombin-	thrombin-	PUNCT	:	_	_	_	_	SpaceAfter=No
5	stimulated	stimulate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
6	fixed	fix	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
7	platelets	platelet	NOUN	NNS	Number=Plur	_	_	_	_
8	bound	bound	ADJ	JJ	Degree=Pos	_	_	_	_
9	to	to	ADP	IN	_	_	_	_	_
10	neutrophils	neutrophil	NOUN	NNS	Number=Plur	_	_	_	_
11	and	and	CCONJ	CC	_	_	_	_	_
12	monocytes	monocyte	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
13	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 297
# text = Within 2 hours, this resulted in increased mRNA for interleukin (IL),1 beta, IL-8, and monocyte chemoattractant protein (MCP)-1 in unfractionated leukocytes.
1	Within	within	ADP	IN	_	_	_	_	_
2	2	2	NUM	CD	NumType=Card	_	_	_	_
3	hours	hour	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	,	,	PUNCT	,	_	_	_	_	_
5	this	this	PRON	DT	Number=Sing|PronType=Dem	_	_	_	_
6	resulted	result	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
7	in	in	ADP	IN	_	_	_	_	_
8	increased	increase	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
9	mRNA	mRNa	NOUN	NN	Number=Sing	_	_	_	_
10	for	for	ADP	IN	_	_	_	_	_
11	interleukin	interleukin	NOUN	NN	Number=Sing	_	_	_	_
12	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
13	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
14	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
15	,1	,1	NUM	CD	NumType=Card	_	_	_	_
16	beta	beta	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
17	,	,	PUNCT	,	_	_	_	_	_
18	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
19	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
20	8	8	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
21	,	,	PUNCT	,	_	_	_	_	_
22	and	and	CCONJ	CC	_	_	_	_	_
23	monocyte	monocyte	ADJ	JJ	Degree=Pos	_	_	_	_
24	chemoattractant	chemoattractant	NOUN	NN	Number=Sing	_	_	_	_
25	protein	protein	NOUN	NN	Number=Sing	_	_	_	_
26	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
27	MCP	MCP	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
28	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
29	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
30	1	1	NUM	CD	NumType=Card	_	_	_	_
31	in	in	ADP	IN	_	_	_	_	_
32	unfractionated	unfractionated	ADJ	JJ	Degree=Pos	_	_	_	_
33	leukocytes	leukocyte	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
34	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 298
# text = After 4 hours, IL-1 beta and IL-8 concentration of the cell-free supernatant had increased by 268 +/- 36% and 210 +/- 7%, respectively, and cellular MCP-1 content had increased by 170 +/- 8%.
1	After	after	ADP	IN	_	_	_	_	_
2	4	4	NUM	CD	NumType=Card	_	_	_	_
3	hours	hour	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	,	,	PUNCT	,	_	_	_	_	_
5	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
6	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
7	1	1	NUM	CD	NumType=Card	_	_	_	_
8	beta	beta	NOUN	NN	Number=Sing	_	_	_	_
9	and	and	CCONJ	CC	_	_	_	_	_
10	IL	Il	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
11	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
12	8	8	NUM	CD	NumType=Card	_	_	_	_
13	concentration	concentration	NOUN	NN	Number=Sing	_	_	_	_
14	of	of	ADP	IN	_	_	_	_	_
15	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
16	cell	cell	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
17	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
18	free	free	ADJ	JJ	Degree=Pos	_	_	_	_
19	supernatant	supernatant	NOUN	NN	Number=Sing	_	_	_	_
20	had	have	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
21	increased	increase	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
22	by	by	ADP	IN	_	_	_	_	_
23	268	268	NUM	CD	NumType=Card	_	_	_	_
24	+/-	+/-	SYM	SYM	_	_	_	_	_
25	36	36	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
26	%	%	SYM	NN	Number=Sing	_	_	_	_
27	and	and	CCONJ	CC	_	_	_	_	_
28	210	210	NUM	CD	NumType=Card	_	_	_	_
29	+/-	+/-	SYM	SYM	_	_	_	_	_
30	7	7	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
31	%	%	SYM	NN	Number=Sing	_	_	_	SpaceAfter=No
32	,	,	PUNCT	,	_	_	_	_	_
33	respectively	respectively	ADV	RB	_	_	_	_	SpaceAfter=No
34	,	,	PUNCT	,	_	_	_	_	_
35	and	and	CCONJ	CC	_	_	_	_	_
36	cellular	cellular	ADJ	JJ	Degree=Pos	_	_	_	_
37	MCP	Mcp	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
38	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
39	1	1	NUM	CD	NumType=Card	_	_	_	_
40	content	content	NOUN	NN	Number=Sing	_	_	_	_
41	had	have	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
42	increased	increase	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
43	by	by	ADP	IN	_	_	_	_	_
44	170	170	NUM	CD	NumType=Card	_	_	_	_
45	+/-	+/-	SYM	SYM	_	_	_	_	_
46	8%	8%	SYM	NN	Number=Sing	_	_	_	SpaceAfter=No
47	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 299
# text = Addition of activated platelets to adherent monocytes had a similar effect and was associated with nuclear factor-kappa B activation.
1	Addition	Addition	NOUN	NN	Number=Sing	_	_	_	_
2	of	of	ADP	IN	_	_	_	_	_
3	activated	activate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
4	platelets	platelet	NOUN	NNS	Number=Plur	_	_	_	_
5	to	to	ADP	IN	_	_	_	_	_
6	adherent	adherent	ADJ	JJ	Degree=Pos	_	_	_	_
7	monocytes	monocyte	NOUN	NNS	Number=Plur	_	_	_	_
8	had	have	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
9	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
10	similar	similar	ADJ	JJ	Degree=Pos	_	_	_	_
11	effect	effect	NOUN	NN	Number=Sing	_	_	_	_
12	and	and	CCONJ	CC	_	_	_	_	_
13	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
14	associated	associate	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
15	with	with	ADP	IN	_	_	_	_	_
16	nuclear	nuclear	ADJ	JJ	Degree=Pos	_	_	_	_
17	factor	factor	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
18	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
19	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_
20	B	b	NOUN	NN	Number=Sing	_	_	_	_
21	activation	activation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
22	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 300
# text = Inhibition of binding by anti-P selectin antibodies reduced the effect of activated platelets on cytokine production.
1	Inhibition	Inhibition	NOUN	NN	Number=Sing	_	_	_	_
2	of	of	SCONJ	IN	_	_	_	_	_
3	binding	bind	VERB	VBG	VerbForm=Ger	_	_	_	_
4	by	by	ADP	IN	_	_	_	_	_
5	anti	anti	X	AFX	_	_	_	_	SpaceAfter=No
6	-P	-p	ADJ	JJ	Degree=Pos	_	_	_	_
7	selectin	selectin	NOUN	NN	Number=Sing	_	_	_	_
8	antibodies	antibody	NOUN	NNS	Number=Plur	_	_	_	_
9	reduced	reduce	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
10	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
11	effect	effect	NOUN	NN	Number=Sing	_	_	_	_
12	of	of	ADP	IN	_	_	_	_	_
13	activated	activated	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
14	platelets	platelet	NOUN	NNS	Number=Plur	_	_	_	_
15	on	on	ADP	IN	_	_	_	_	_
16	cytokine	cytokine	NOUN	NN	Number=Sing	_	_	_	_
17	production	production	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
18	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 301
# text = CONCLUSIONS:
1	CONCLUSIONS	conclusion	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
2	:	:	PUNCT	:	_	_	_	_	_

# sent_id = 302
# text = In patients with AMI, leukocyte-platelet adhesion is increased.
1	In	in	ADP	IN	_	_	_	_	_
2	patients	patient	NOUN	NN	Number=Sing	_	_	_	_
3	with	with	ADP	IN	_	_	_	_	_
4	AMI	AMI	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
5	,	,	PUNCT	,	_	_	_	_	_
6	leukocyte	leukocyte	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
7	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
8	platelet	platelet	NOUN	NN	Number=Sing	_	_	_	_
9	adhesion	adhesion	NOUN	NN	Number=Sing	_	_	_	_
10	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
11	increased	increased	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	SpaceAfter=No
12	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 303
# text = Binding of activated platelets induces IL-1 beta, IL-8, and MCP-1 in leukocytes.
1	Binding	binding	NOUN	NN	Number=Sing	_	_	_	_
2	of	of	ADP	IN	_	_	_	_	_
3	activated	activate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
4	platelets	platelet	NOUN	NNS	Number=Plur	_	_	_	_
5	induces	induce	NOUN	NNS	Number=Plur	_	_	_	_
6	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
7	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
8	1	1	NUM	CD	NumType=Card	_	_	_	_
9	beta	beta	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
10	,	,	PUNCT	,	_	_	_	_	_
11	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
12	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
13	8	8	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
14	,	,	PUNCT	,	_	_	_	_	_
15	and	and	CCONJ	CC	_	_	_	_	_
16	MCP	MCP	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
17	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
18	1	1	NUM	CD	NumType=Card	_	_	_	_
19	in	in	ADP	IN	_	_	_	_	_
20	leukocytes	leukocyte	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
21	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 304
# text = Our findings suggest that leukocyte-platelet adhesion contributes to the regulation of inflammatory responses in AMI.
1	Our	we	PRON	PRP$	Number=Plur|Person=1|Poss=Yes|PronType=Prs	_	_	_	_
2	findings	finding	NOUN	NNS	Number=Plur	_	_	_	_
3	suggest	suggest	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
4	that	that	SCONJ	IN	_	_	_	_	_
5	leukocyte	leukocyte	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
6	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
7	platelet	platelet	NOUN	NN	Number=Sing	_	_	_	_
8	adhesion	adhesion	NOUN	NN	Number=Sing	_	_	_	_
9	contributes	contribute	NOUN	NNS	Number=Plur	_	_	_	_
10	to	to	ADP	IN	_	_	_	_	_
11	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
12	regulation	regulation	NOUN	NN	Number=Sing	_	_	_	_
13	of	of	ADP	IN	_	_	_	_	_
14	inflammatory	inflammatory	ADJ	JJ	Degree=Pos	_	_	_	_
15	responses	response	NOUN	NNS	Number=Plur	_	_	_	_
16	in	in	ADP	IN	_	_	_	_	_
17	AMI	AMI	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
18	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 305
# text = Document 003002116 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	003002116	003002116	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 306
# text = Paternal expression of WT1 in human fibroblasts and lymphocytes.
1	Paternal	Paternal	ADJ	JJ	Degree=Pos	_	_	_	_
2	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
3	of	of	ADP	IN	_	_	_	_	_
4	WT1	wt1	NUM	CD	NumType=Card	_	_	_	_
5	in	in	ADP	IN	_	_	_	_	_
6	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
7	fibroblasts	fibroblast	NOUN	NNS	Number=Plur	_	_	_	_
8	and	and	CCONJ	CC	_	_	_	_	_
9	lymphocytes	lymphocyte	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
10	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 307
# text = The Wilms' tumor suppressor gene ( WT1 ) was previously identified as being imprinted, with frequent maternal expression in human placentae and fetal brains.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	Wilms	Wilm	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
3	'	's	PART	POS	_	_	_	_	_
4	tumor	tumor	NOUN	NN	Number=Sing	_	_	_	_
5	suppressor	suppressor	NOUN	NN	Number=Sing	_	_	_	_
6	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
7	(	(	PUNCT	-LRB-	_	_	_	_	_
8	WT1	wt1	PROPN	NNP	Number=Sing	_	_	_	_
9	)	)	PUNCT	-RRB-	_	_	_	_	_
10	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
11	previously	previously	ADV	RB	_	_	_	_	_
12	identified	identify	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
13	as	as	SCONJ	IN	_	_	_	_	_
14	being	be	AUX	VBG	VerbForm=Ger	_	_	_	_
15	imprinted	imprinted	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	SpaceAfter=No
16	,	,	PUNCT	,	_	_	_	_	_
17	with	with	ADP	IN	_	_	_	_	_
18	frequent	frequent	ADJ	JJ	Degree=Pos	_	_	_	_
19	maternal	maternal	ADJ	JJ	Degree=Pos	_	_	_	_
20	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
21	in	in	ADP	IN	_	_	_	_	_
22	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
23	placentae	placenta	NOUN	NN	Number=Sing	_	_	_	_
24	and	and	CCONJ	CC	_	_	_	_	_
25	fetal	fetal	ADJ	JJ	Degree=Pos	_	_	_	_
26	brains	brain	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
27	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 308
# text = We examined the allele-specific expression of WT1 in cultured human fibroblasts from 15 individuals.
1	We	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
2	examined	examin	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
3	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
4	allele	allele	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
5	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
6	specific	specific	ADJ	JJ	Degree=Pos	_	_	_	_
7	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
8	of	of	ADP	IN	_	_	_	_	_
9	WT1	WT1	NUM	CD	NumType=Card	_	_	_	_
10	in	in	ADP	IN	_	_	_	_	_
11	cultured	culture	ADJ	JJ	Degree=Pos	_	_	_	_
12	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
13	fibroblasts	fibroblast	NOUN	NNS	Number=Plur	_	_	_	_
14	from	from	ADP	IN	_	_	_	_	_
15	15	15	NUM	CD	NumType=Card	_	_	_	_
16	individuals	individual	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
17	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 309
# text = Seven of 15 fibroblast lines were heterozygous for polymorphic alleles, and the expression patterns were variable, i.e., equal, unequal or monoallelic paternal expression in three, two and two cases, respectively.
1	Seven	Seven	PROPN	NNP	Number=Sing	_	_	_	_
2	of	of	ADP	IN	_	_	_	_	_
3	15	15	NUM	CD	NumType=Card	_	_	_	_
4	fibroblast	fibroblast	ADJ	JJ	Degree=Pos	_	_	_	_
5	lines	line	NOUN	NNS	Number=Plur	_	_	_	_
6	were	be	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
7	heterozygous	heterozygous	ADJ	JJ	Degree=Pos	_	_	_	_
8	for	for	ADP	IN	_	_	_	_	_
9	polymorphic	polymorphic	ADJ	JJ	Degree=Pos	_	_	_	_
10	alleles	allele	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
11	,	,	PUNCT	,	_	_	_	_	_
12	and	and	CCONJ	CC	_	_	_	_	_
13	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
14	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
15	patterns	pattern	NOUN	NNS	Number=Plur	_	_	_	_
16	were	be	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
17	variable	variable	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
18	,	,	PUNCT	,	_	_	_	_	_
19	i.e.	i.e.	X	FW	_	_	_	_	SpaceAfter=No
20	,	,	PUNCT	,	_	_	_	_	_
21	equal	equal	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
22	,	,	PUNCT	,	_	_	_	_	_
23	unequal	unequal	ADJ	JJ	Degree=Pos	_	_	_	_
24	or	or	CCONJ	CC	_	_	_	_	_
25	monoallelic	monoallelic	ADJ	JJ	Degree=Pos	_	_	_	_
26	paternal	paternal	ADJ	JJ	Degree=Pos	_	_	_	_
27	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
28	in	in	ADP	IN	_	_	_	_	_
29	three	three	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
30	,	,	PUNCT	,	_	_	_	_	_
31	two	two	NUM	CD	NumType=Card	_	_	_	_
32	and	and	CCONJ	CC	_	_	_	_	_
33	two	two	NUM	CD	NumType=Card	_	_	_	_
34	cases	case	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
35	,	,	PUNCT	,	_	_	_	_	_
36	respectively	respectively	ADV	RB	_	_	_	_	SpaceAfter=No
37	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 310
# text = Exclusive paternal expression of WT1 was also shown in non-cultured peripheral lymphocytes from the latter two individuals.
1	Exclusive	Exclusive	ADJ	JJ	Degree=Pos	_	_	_	_
2	paternal	paternal	ADJ	JJ	Degree=Pos	_	_	_	_
3	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
4	of	of	ADP	IN	_	_	_	_	_
5	WT1	WT1	PROPN	NNP	Number=Sing	_	_	_	_
6	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
7	also	also	ADV	RB	_	_	_	_	_
8	shown	show	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
9	in	in	ADP	IN	_	_	_	_	_
10	non-cultured	non-cultured	ADJ	JJ	Degree=Pos	_	_	_	_
11	peripheral	peripheral	ADJ	JJ	Degree=Pos	_	_	_	_
12	lymphocytes	lymphocyte	NOUN	NNS	Number=Plur	_	_	_	_
13	from	from	ADP	IN	_	_	_	_	_
14	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
15	latter	latter	ADJ	JJ	Degree=Pos	_	_	_	_
16	two	two	NUM	CD	NumType=Card	_	_	_	_
17	individuals	individual	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
18	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 311
# text = The allele-specific expression profiles of other imprinted genes, IGF2 and H19, on human chromosome 11 were constant and consistent with those in other tissues.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	allele	allele	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
3	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
4	specific	specific	ADJ	JJ	Degree=Pos	_	_	_	_
5	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
6	profiles	profile	NOUN	NNS	Number=Plur	_	_	_	_
7	of	of	ADP	IN	_	_	_	_	_
8	other	other	ADJ	JJ	Degree=Pos	_	_	_	_
9	imprinted	imprint	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
10	genes	gene	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
11	,	,	PUNCT	,	_	_	_	_	_
12	IGF2	Igf2	NUM	CD	NumType=Card	_	_	_	_
13	and	and	CCONJ	CC	_	_	_	_	_
14	H19	h19	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
15	,	,	PUNCT	,	_	_	_	_	_
16	on	on	ADP	IN	_	_	_	_	_
17	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
18	chromosome	chromosome	NOUN	NN	Number=Sing	_	_	_	_
19	11	11	NUM	CD	NumType=Card	_	_	_	_
20	were	be	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
21	constant	constant	ADJ	JJ	Degree=Pos	_	_	_	_
22	and	and	CCONJ	CC	_	_	_	_	_
23	consistent	consistent	ADJ	JJ	Degree=Pos	_	_	_	_
24	with	with	ADP	IN	_	_	_	_	_
25	those	those	PRON	DT	Number=Plur|PronType=Dem	_	_	_	_
26	in	in	ADP	IN	_	_	_	_	_
27	other	other	ADJ	JJ	Degree=Pos	_	_	_	_
28	tissues	tissue	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
29	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 312
# text = Our unexpected observations of paternal or biallelic expression of WT1 in fibroblasts and lymphocytes, together with the previous findings of maternal or biallelic expression in placentae and brains, suggest that the allele-specific regulatory system of WT1 is unique and may be controlled by a putative tissue- and individual-specific modifier.
1	Our	we	PRON	PRP$	Number=Plur|Person=1|Poss=Yes|PronType=Prs	_	_	_	_
2	unexpected	unexpected	ADJ	JJ	Degree=Pos	_	_	_	_
3	observations	observation	NOUN	NNS	Number=Plur	_	_	_	_
4	of	of	ADP	IN	_	_	_	_	_
5	paternal	paternal	ADJ	JJ	Degree=Pos	_	_	_	_
6	or	or	CCONJ	CC	_	_	_	_	_
7	biallelic	biallelic	ADJ	JJ	Degree=Pos	_	_	_	_
8	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
9	of	of	ADP	IN	_	_	_	_	_
10	WT1	wt1	NUM	CD	NumType=Card	_	_	_	_
11	in	in	ADP	IN	_	_	_	_	_
12	fibroblasts	fibroblast	NOUN	NNS	Number=Plur	_	_	_	_
13	and	and	CCONJ	CC	_	_	_	_	_
14	lymphocytes	lymphocyte	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
15	,	,	PUNCT	,	_	_	_	_	_
16	together	together	ADV	RB	_	_	_	_	_
17	with	with	ADP	IN	_	_	_	_	_
18	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
19	previous	previous	ADJ	JJ	Degree=Pos	_	_	_	_
20	findings	finding	NOUN	NNS	Number=Plur	_	_	_	_
21	of	of	ADP	IN	_	_	_	_	_
22	maternal	maternal	ADJ	JJ	Degree=Pos	_	_	_	_
23	or	or	CCONJ	CC	_	_	_	_	_
24	biallelic	biallelic	ADJ	JJ	Degree=Pos	_	_	_	_
25	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
26	in	in	ADP	IN	_	_	_	_	_
27	placentae	placenta	NOUN	NN	Number=Sing	_	_	_	_
28	and	and	CCONJ	CC	_	_	_	_	_
29	brains	brains	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
30	,	,	PUNCT	,	_	_	_	_	_
31	suggest	suggest	VERB	VB	Mood=Imp|VerbForm=Fin	_	_	_	_
32	that	that	SCONJ	IN	_	_	_	_	_
33	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
34	allele	allele	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
35	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
36	specific	specific	ADJ	JJ	Degree=Pos	_	_	_	_
37	regulatory	regulatory	ADJ	JJ	Degree=Pos	_	_	_	_
38	system	system	NOUN	NN	Number=Sing	_	_	_	_
39	of	of	ADP	IN	_	_	_	_	_
40	WT1	wt1	NUM	CD	NumType=Card	_	_	_	_
41	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
42	unique	unique	ADJ	JJ	Degree=Pos	_	_	_	_
43	and	and	CCONJ	CC	_	_	_	_	_
44	may	may	AUX	MD	VerbForm=Fin	_	_	_	_
45	be	be	AUX	VB	VerbForm=Inf	_	_	_	_
46	controlled	controll	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
47	by	by	ADP	IN	_	_	_	_	_
48	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
49	putative	putative	ADJ	JJ	Degree=Pos	_	_	_	_
50	tissue	tissue	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
51	-	-	PUNCT	,	_	_	_	_	_
52	and	and	CCONJ	CC	_	_	_	_	_
53	individual	individual	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
54	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
55	specific	specific	ADJ	JJ	Degree=Pos	_	_	_	_
56	modifier	modifier	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
57	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 313
# text = Document 003002117 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	003002117	003002117	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 314
# text = Activation of primary human T-lymphocytes through CD2 plus CD28 adhesion molecules induces long-term nuclear expression of NF-kappa B. Stimulation of highly purified human T-cells via CD2 and CD28 adhesion molecules induces and maintains proliferation for more than 3 weeks.
1	Activation	Activation	NOUN	NN	Number=Sing	_	_	_	_
2	of	of	ADP	IN	_	_	_	_	_
3	primary	primary	ADJ	JJ	Degree=Pos	_	_	_	_
4	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
5	T-	t-	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
6	lymphocytes	lymphocyte	NOUN	NNS	Number=Plur	_	_	_	_
7	through	through	ADP	IN	_	_	_	_	_
8	CD2	CD2	NUM	CD	NumType=Card	_	_	_	_
9	plus	plus	CCONJ	CC	_	_	_	_	_
10	CD28	CD28	NUM	CD	NumType=Card	_	_	_	_
11	adhesion	adhesion	NOUN	NN	Number=Sing	_	_	_	_
12	molecules	molecule	NOUN	NNS	Number=Plur	_	_	_	_
13	induces	induce	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
14	long	long	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
15	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
16	term	term	NOUN	NN	Number=Sing	_	_	_	_
17	nuclear	nuclear	ADJ	JJ	Degree=Pos	_	_	_	_
18	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
19	of	of	ADP	IN	_	_	_	_	_
20	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
21	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
22	kappa	kappa	PROPN	NNP	Number=Sing	_	_	_	_
23	B.	B.	PROPN	NNP	Number=Sing	_	_	_	SpacesAfter=\s\n
24	Stimulation	Stimulation	NOUN	NN	Number=Sing	_	_	_	_
25	of	of	ADP	IN	_	_	_	_	_
26	highly	highly	ADV	RB	_	_	_	_	_
27	purified	purify	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
28	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
29	T-	t-	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
30	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
31	via	via	ADP	IN	_	_	_	_	_
32	CD2	Cd2	NOUN	NN	Number=Sing	_	_	_	_
33	and	and	CCONJ	CC	_	_	_	_	_
34	CD28	Cd28	NUM	CD	NumType=Card	_	_	_	_
35	adhesion	adhesion	NOUN	NN	Number=Sing	_	_	_	_
36	molecules	molecule	NOUN	NNS	Number=Plur	_	_	_	_
37	induces	induce	NOUN	NNS	Number=Plur	_	_	_	_
38	and	and	CCONJ	CC	_	_	_	_	_
39	maintains	maintain	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
40	proliferation	proliferation	NOUN	NN	Number=Sing	_	_	_	_
41	for	for	ADP	IN	_	_	_	_	_
42	more	more	ADJ	JJR	Degree=Cmp	_	_	_	_
43	than	than	ADP	IN	_	_	_	_	_
44	3	3	NUM	CD	NumType=Card	_	_	_	_
45	weeks	week	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
46	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 315
# text = This potent interleukin 2 (IL-2)-dependent activation does not require monocytes or accessory cells.
1	This	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
2	potent	potent	NOUN	NN	Number=Sing	_	_	_	_
3	interleukin	interleukin	NOUN	NN	Number=Sing	_	_	_	_
4	2	2	NUM	CD	NumType=Card	_	_	_	_
5	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
6	IL	Il	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
7	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
8	2	2	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
9	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
10	-	-	PUNCT	:	_	_	_	_	SpaceAfter=No
11	dependent	dependent	ADJ	JJ	Degree=Pos	_	_	_	_
12	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
13	does	do	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
14	not	not	PART	RB	_	_	_	_	_
15	require	require	VERB	VB	VerbForm=Inf	_	_	_	_
16	monocytes	monocyte	NOUN	NNS	Number=Plur	_	_	_	_
17	or	or	CCONJ	CC	_	_	_	_	_
18	accessory	accessory	ADJ	JJ	Degree=Pos	_	_	_	_
19	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
20	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 316
# text = Long-lasting IL-2 receptivity is associated with high-level expression of the inducible IL-2 receptor alpha chain (IL-2R alpha) gene that is regulated at both transcriptional and posttranscriptional levels.
1	Long	long	ADV	RB	Degree=Pos	_	_	_	SpaceAfter=No
2	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
3	lasting	last	VERB	VBG	VerbForm=Ger	_	_	_	_
4	IL	Il	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
5	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
6	2	2	NUM	CD	NumType=Card	_	_	_	_
7	receptivity	receptivity	NOUN	NN	Number=Sing	_	_	_	_
8	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
9	associated	associate	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
10	with	with	ADP	IN	_	_	_	_	_
11	high	high	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
12	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
13	level	level	NOUN	NN	Number=Sing	_	_	_	_
14	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
15	of	of	ADP	IN	_	_	_	_	_
16	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
17	inducible	inducible	ADJ	JJ	Degree=Pos	_	_	_	_
18	IL	Il	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
19	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
20	2	2	NUM	CD	NumType=Card	_	_	_	_
21	receptor	receptor	NOUN	NN	Number=Sing	_	_	_	_
22	alpha	alpha	NOUN	NN	Number=Sing	_	_	_	_
23	chain	chain	NOUN	NN	Number=Sing	_	_	_	_
24	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
25	IL	Il	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
26	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
27	2R	2r	NOUN	NN	Number=Sing	_	_	_	_
28	alpha	alpha	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
29	)	)	PUNCT	-RRB-	_	_	_	_	_
30	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
31	that	that	PRON	WDT	PronType=Rel	_	_	_	_
32	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
33	regulated	regulate	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
34	at	at	ADP	IN	_	_	_	_	_
35	both	both	CCONJ	CC	_	_	_	_	_
36	transcriptional	transcriptional	ADJ	JJ	Degree=Pos	_	_	_	_
37	and	and	CCONJ	CC	_	_	_	_	_
38	posttranscriptional	posttranscriptional	ADJ	JJ	Degree=Pos	_	_	_	_
39	levels	level	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
40	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 317
# text = Increase of IL-2R alpha gene transcription involves the enhanced binding of the transcription factor NF-kappa B to its consensus sequence in the 5'-regulatory region of the IL-2R alpha gene.
1	Increase	increase	NOUN	NN	Number=Sing	_	_	_	_
2	of	of	ADP	IN	_	_	_	_	_
3	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
4	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
5	2R	2R	PROPN	NNP	Number=Sing	_	_	_	_
6	alpha	alpha	NOUN	NN	Number=Sing	_	_	_	_
7	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
8	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
9	involves	involve	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
10	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
11	enhanced	enhance	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
12	binding	binding	NOUN	NN	Number=Sing	_	_	_	_
13	of	of	ADP	IN	_	_	_	_	_
14	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
15	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
16	factor	factor	NOUN	NN	Number=Sing	_	_	_	_
17	NF	Nf	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
18	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
19	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_
20	B	b	NOUN	NN	Number=Sing	_	_	_	_
21	to	to	ADP	IN	_	_	_	_	_
22	its	its	PRON	PRP$	Gender=Neut|Number=Sing|Person=3|Poss=Yes|PronType=Prs	_	_	_	_
23	consensus	consensus	NOUN	NN	Number=Sing	_	_	_	_
24	sequence	sequence	NOUN	NN	Number=Sing	_	_	_	_
25	in	in	ADP	IN	_	_	_	_	_
26	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
27	5	5	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
28	'	'	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
29	-	-	SYM	SYM	_	_	_	_	SpaceAfter=No
30	regulatory	regulatory	ADJ	JJ	Degree=Pos	_	_	_	_
31	region	region	NOUN	NN	Number=Sing	_	_	_	_
32	of	of	ADP	IN	_	_	_	_	_
33	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
34	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
35	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
36	2R	2R	PROPN	NNP	Number=Sing	_	_	_	_
37	alpha	alpha	ADP	IN	_	_	_	_	_
38	gene	gene	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
39	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 318
# text = To dissect the molecular basis for the unusually persistent transcription of the IL-2R alpha gene, we analyzed nuclear NF-kappa B binding to a radiolabeled IL-2R alpha kappa B-specific oligonucleotide probe during the time course of CD2 + CD28 activation.
1	To	to	PART	TO	_	_	_	_	_
2	dissect	dissect	VERB	VB	VerbForm=Inf	_	_	_	_
3	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
4	molecular	molecular	ADJ	JJ	Degree=Pos	_	_	_	_
5	basis	basis	NOUN	NN	Number=Sing	_	_	_	_
6	for	for	ADP	IN	_	_	_	_	_
7	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
8	unusually	unusually	ADJ	JJ	Degree=Pos	_	_	_	_
9	persistent	persistent	ADJ	JJ	Degree=Pos	_	_	_	_
10	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
11	of	of	ADP	IN	_	_	_	_	_
12	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
13	IL	Il	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
14	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
15	2R	2r	PROPN	NNP	Number=Sing	_	_	_	_
16	alpha	alpha	NOUN	NN	Number=Sing	_	_	_	_
17	gene	gene	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
18	,	,	PUNCT	,	_	_	_	_	_
19	we	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
20	analyzed	analyze	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
21	nuclear	nuclear	ADJ	JJ	Degree=Pos	_	_	_	_
22	NF	Nf	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
23	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
24	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_
25	B	b	NOUN	NN	Number=Sing	_	_	_	_
26	binding	bind	VERB	VBG	VerbForm=Ger	_	_	_	_
27	to	to	ADP	IN	_	_	_	_	_
28	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
29	radiolabeled	radiolabel	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
30	IL	Il	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
31	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
32	2R	2r	PROPN	NNP	Number=Sing	_	_	_	_
33	alpha	alpha	ADP	IN	_	_	_	_	_
34	kappa	kappa	PROPN	NNP	Number=Sing	_	_	_	_
35	B	b	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
36	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
37	specific	specific	ADJ	JJ	Degree=Pos	_	_	_	_
38	oligonucleotide	oligonucleotide	ADJ	JJ	Degree=Pos	_	_	_	_
39	probe	probe	NOUN	NN	Number=Sing	_	_	_	_
40	during	during	ADP	IN	_	_	_	_	_
41	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
42	time	time	NOUN	NN	Number=Sing	_	_	_	_
43	course	course	NOUN	NN	Number=Sing	_	_	_	_
44	of	of	ADP	IN	_	_	_	_	_
45	CD2	CD2	NUM	CD	NumType=Card	_	_	_	_
46	+	+	SYM	SYM	_	_	_	_	_
47	CD28	CD28	NUM	CD	NumType=Card	_	_	_	_
48	activation	activation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
49	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 319
# text = Resting T-cell nuclear extracts contained KBF1/p50 homodimer.
1	Resting	reste	NOUN	NN	Number=Sing	_	_	_	_
2	T-	T-	PUNCT	:	_	_	_	_	SpaceAfter=No
3	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
4	nuclear	nuclear	ADJ	JJ	Degree=Pos	_	_	_	_
5	extracts	extract	NOUN	NNS	Number=Plur	_	_	_	_
6	contained	contain	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
7	KBF1	KBF1	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
8	/	/	PUNCT	,	_	_	_	_	SpaceAfter=No
9	p50	p50	NUM	CD	NumType=Card	_	_	_	_
10	homodimer	homodimer	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
11	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 320
# text = After stimulation, two new kappa B-specific complexes were identified as NF-kappa B p50-p65 heterodimer and putative c-Rel homodimer or c-Rel-p65 heterodimer.
1	After	after	ADP	IN	_	_	_	_	_
2	stimulation	stimulation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
3	,	,	PUNCT	,	_	_	_	_	_
4	two	two	NUM	CD	NumType=Card	_	_	_	_
5	new	new	ADJ	JJ	Degree=Pos	_	_	_	_
6	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_
7	B-	B-	SYM	NFP	_	_	_	_	SpaceAfter=No
8	specific	specific	ADJ	JJ	Degree=Pos	_	_	_	_
9	complexes	complexe	NOUN	NNS	Number=Plur	_	_	_	_
10	were	be	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
11	identified	identify	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
12	as	as	ADP	IN	_	_	_	_	_
13	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
14	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
15	kappa	kappa	PROPN	NNP	Number=Sing	_	_	_	_
16	B	b	NOUN	NN	Number=Sing	_	_	_	_
17	p50	p50	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
18	-	-	SYM	SYM	_	_	_	_	SpaceAfter=No
19	p65	p65	NUM	CD	NumType=Card	_	_	_	_
20	heterodimer	heterodimer	NOUN	NN	Number=Sing	_	_	_	_
21	and	and	CCONJ	CC	_	_	_	_	_
22	putative	putative	ADJ	JJ	Degree=Pos	_	_	_	_
23	c-	c-	PUNCT	,	_	_	_	_	SpaceAfter=No
24	Rel	Rel	ADJ	JJ	Degree=Pos	_	_	_	_
25	homodimer	homodimer	NOUN	NN	Number=Sing	_	_	_	_
26	or	or	CCONJ	CC	_	_	_	_	_
27	c	c	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
28	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
29	Rel	Rel	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
30	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
31	p65	p65	NUM	CD	NumType=Card	_	_	_	_
32	heterodimer	heterodimer	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
33	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 321
# text = Both inducible complexes persisted for at least 3 weeks.
1	Both	both	DET	DT	_	_	_	_	_
2	inducible	inducible	ADJ	JJ	Degree=Pos	_	_	_	_
3	complexes	complexe	NOUN	NNS	Number=Plur	_	_	_	_
4	persisted	persist	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
5	for	for	ADP	IN	_	_	_	_	_
6	at	at	ADV	RB	_	_	_	_	_
7	least	least	ADV	RBS	Degree=Sup	_	_	_	_
8	3	3	NUM	CD	NumType=Card	_	_	_	_
9	weeks	week	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
10	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 322
# text = Their relative levels were very similar for the duration of proliferation.
1	Their	they	PRON	PRP$	Number=Plur|Person=3|Poss=Yes|PronType=Prs	_	_	_	_
2	relative	relative	ADJ	JJ	Degree=Pos	_	_	_	_
3	levels	level	NOUN	NNS	Number=Plur	_	_	_	_
4	were	be	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
5	very	very	ADV	RB	_	_	_	_	_
6	similar	similar	ADJ	JJ	Degree=Pos	_	_	_	_
7	for	for	ADP	IN	_	_	_	_	_
8	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
9	duration	duration	NOUN	NN	Number=Sing	_	_	_	_
10	of	of	ADP	IN	_	_	_	_	_
11	proliferation	proliferation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
12	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 323
# text = In parallel, CD2 + CD28 activation triggered a significant intracellular thiol decrease, suggesting that oxygen radicals are involved in the signaling pathway of adhesion molecules.
1	In	in	ADP	IN	_	_	_	_	_
2	parallel	parallel	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
3	,	,	PUNCT	,	_	_	_	_	_
4	CD2	CD2	NUM	CD	NumType=Card	_	_	_	_
5	+	+	SYM	SYM	_	_	_	_	_
6	CD28	CD28	NUM	CD	NumType=Card	_	_	_	_
7	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
8	triggered	trigger	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
9	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
10	significant	significant	ADJ	JJ	Degree=Pos	_	_	_	_
11	intracellular	intracellular	ADJ	JJ	Degree=Pos	_	_	_	_
12	thiol	thiol	NOUN	NN	Number=Sing	_	_	_	_
13	decrease	decrease	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
14	,	,	PUNCT	,	_	_	_	_	_
15	suggesting	suggest	VERB	VBG	VerbForm=Ger	_	_	_	_
16	that	that	SCONJ	IN	_	_	_	_	_
17	oxygen	oxygen	ADJ	JJ	Degree=Pos	_	_	_	_
18	radicals	radical	NOUN	NNS	Number=Plur	_	_	_	_
19	are	be	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
20	involved	involved	ADJ	JJ	Degree=Pos	_	_	_	_
21	in	in	ADP	IN	_	_	_	_	_
22	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
23	signaling	signal	NOUN	NN	Number=Sing	_	_	_	_
24	pathway	pathway	NOUN	NN	Number=Sing	_	_	_	_
25	of	of	ADP	IN	_	_	_	_	_
26	adhesion	adhesion	NOUN	NN	Number=Sing	_	_	_	_
27	molecules	molecule	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
28	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 324
# text = Finally, micromolar amounts of pyrrolidine dithiocarbamate, an oxygen radical scavenger that efficiently blocked the nuclear appearance of NF-kappa B in T-lymphocytes, also inhibited IL-2 secretion, IL-2R alpha cell surface expression, and T-cell proliferation.
1	Finally	finally	ADV	RB	_	_	_	_	SpaceAfter=No
2	,	,	PUNCT	,	_	_	_	_	_
3	micromolar	micromolar	ADJ	JJ	Degree=Pos	_	_	_	_
4	amounts	amount	NOUN	NNS	Number=Plur	_	_	_	_
5	of	of	ADP	IN	_	_	_	_	_
6	pyrrolidine	pyrrolidine	NOUN	NN	Number=Sing	_	_	_	_
7	dithiocarbamate	dithiocarbamate	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
8	,	,	PUNCT	,	_	_	_	_	_
9	an	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
10	oxygen	oxygen	ADJ	JJ	Degree=Pos	_	_	_	_
11	radical	radical	ADJ	JJ	Degree=Pos	_	_	_	_
12	scavenger	scavenger	NOUN	NN	Number=Sing	_	_	_	_
13	that	that	PRON	WDT	PronType=Rel	_	_	_	_
14	efficiently	efficiently	ADV	RB	_	_	_	_	_
15	blocked	block	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
16	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
17	nuclear	nuclear	ADJ	JJ	Degree=Pos	_	_	_	_
18	appearance	appearance	NOUN	NN	Number=Sing	_	_	_	_
19	of	of	ADP	IN	_	_	_	_	_
20	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
21	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
22	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_
23	B	b	NOUN	NN	Number=Sing	_	_	_	_
24	in	in	ADP	IN	_	_	_	_	_
25	T-	t-	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
26	lymphocytes	lymphocyte	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
27	,	,	PUNCT	,	_	_	_	_	_
28	also	also	ADV	RB	_	_	_	_	_
29	inhibited	inhibit	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
30	IL	IL	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
31	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
32	2	2	NUM	CD	NumType=Card	_	_	_	_
33	secretion	secretion	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
34	,	,	PUNCT	,	_	_	_	_	_
35	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
36	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
37	2R	2R	PROPN	NNP	Number=Sing	_	_	_	_
38	alpha	alpha	NOUN	NN	Number=Sing	_	_	_	_
39	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
40	surface	surface	NOUN	NN	Number=Sing	_	_	_	_
41	expression	expression	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
42	,	,	PUNCT	,	_	_	_	_	_
43	and	and	CCONJ	CC	_	_	_	_	_
44	T-	T-	SYM	NFP	_	_	_	_	SpaceAfter=No
45	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
46	proliferation	proliferation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
47	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 325
# text = Together, these results suggest that NF-kappa B plays an important role in long-term activation of human primary T-lymphocytes via CD2 + CD28.
1	Together	together	ADV	RB	_	_	_	_	SpaceAfter=No
2	,	,	PUNCT	,	_	_	_	_	_
3	these	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
4	results	result	NOUN	NNS	Number=Plur	_	_	_	_
5	suggest	suggest	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
6	that	that	SCONJ	IN	_	_	_	_	_
7	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
8	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
9	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_
10	B	b	NOUN	NN	Number=Sing	_	_	_	_
11	plays	play	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
12	an	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
13	important	important	ADJ	JJ	Degree=Pos	_	_	_	_
14	role	role	NOUN	NN	Number=Sing	_	_	_	_
15	in	in	ADP	IN	_	_	_	_	_
16	long	long	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
17	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
18	term	term	NOUN	NN	Number=Sing	_	_	_	_
19	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
20	of	of	ADP	IN	_	_	_	_	_
21	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
22	primary	primary	ADJ	JJ	Degree=Pos	_	_	_	_
23	T-	t-	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
24	lymphocytes	lymphocyte	NOUN	NNS	Number=Plur	_	_	_	_
25	via	via	ADP	IN	_	_	_	_	_
26	CD2	CD2	NUM	CD	NumType=Card	_	_	_	_
27	+	+	SYM	SYM	_	_	_	_	_
28	CD28	CD28	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
29	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 326
# text = Document 003002118 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	003002118	003002118	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 327
# text = Overproduction of NFKB2 (lyt-10) and c-Rel: a mechanism for HTLV-I Tax-mediated trans-activation via the NF-kappa B signalling pathway.
1	Overproduction	Overproduction	NOUN	NN	Number=Sing	_	_	_	_
2	of	of	ADP	IN	_	_	_	_	_
3	NFKB2	NFKB2	NUM	CD	NumType=Card	_	_	_	_
4	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
5	lyt	lyt	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
6	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
7	10	10	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
8	)	)	PUNCT	-RRB-	_	_	_	_	_
9	and	and	CCONJ	CC	_	_	_	_	_
10	c	class	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
11	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
12	Rel	Rel	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
13	:	:	PUNCT	:	_	_	_	_	_
14	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
15	mechanism	mechanism	NOUN	NN	Number=Sing	_	_	_	_
16	for	for	ADP	IN	_	_	_	_	_
17	HTLV	HTLV	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
18	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
19	I	I	PRON	PRP	Case=Nom|Number=Sing|Person=1|PronType=Prs	_	_	_	_
20	Tax	tax	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
21	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
22	mediated	mediate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
23	trans	tran	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
24	-activation	-activation	NOUN	NN	Number=Sing	_	_	_	_
25	via	via	ADP	IN	_	_	_	_	_
26	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
27	NF	Nf	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
28	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
29	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_
30	B	b	NOUN	NN	Number=Sing	_	_	_	_
31	signalling	signall	VERB	VBG	VerbForm=Ger	_	_	_	_
32	pathway	pathway	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
33	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 328
# text = Molecular, biochemical and epidemiological evidence implicate HTLV-I as an etiologic agent of adult T cell leukemia (ATL).
1	Molecular	Molecular	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
2	,	,	PUNCT	,	_	_	_	_	_
3	biochemical	biochemical	ADJ	JJ	Degree=Pos	_	_	_	_
4	and	and	CCONJ	CC	_	_	_	_	_
5	epidemiological	epidemiological	ADJ	JJ	Degree=Pos	_	_	_	_
6	evidence	evidence	NOUN	NN	Number=Sing	_	_	_	_
7	implicate	implicate	ADJ	JJ	Degree=Pos	_	_	_	_
8	HTLV	Htlv	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
9	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
10	I	I	PRON	PRP	Case=Nom|Number=Sing|Person=1|PronType=Prs	_	_	_	_
11	as	as	ADP	IN	_	_	_	_	_
12	an	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
13	etiologic	etiologic	ADJ	JJ	Degree=Pos	_	_	_	_
14	agent	agent	NOUN	NN	Number=Sing	_	_	_	_
15	of	of	ADP	IN	_	_	_	_	_
16	adult	adult	NOUN	NN	Number=Sing	_	_	_	_
17	T	t	PROPN	NNP	Number=Sing	_	_	_	_
18	cell	cell	PROPN	NNP	Number=Sing	_	_	_	_
19	leukemia	leukemia	PROPN	NNP	Number=Sing	_	_	_	_
20	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
21	ATL	ATL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
22	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
23	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 329
# text = The Tax protein of HTLV-I, a positive transcriptional activator of HTLV-I gene expression, is a viral oncogene that also increases transcription of cellular genes including GM-CSF, IL-2R alpha and IL-2.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	Tax	tax	NOUN	NN	Number=Sing	_	_	_	_
3	protein	protein	NOUN	NN	Number=Sing	_	_	_	_
4	of	of	ADP	IN	_	_	_	_	_
5	HTLV	HTLV	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
6	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
7	I	I	PRON	PRP	Case=Nom|Number=Sing|Person=1|PronType=Prs	_	_	_	SpaceAfter=No
8	,	,	PUNCT	,	_	_	_	_	_
9	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
10	positive	positive	ADJ	JJ	Degree=Pos	_	_	_	_
11	transcriptional	transcriptional	ADJ	JJ	Degree=Pos	_	_	_	_
12	activator	activator	NOUN	NN	Number=Sing	_	_	_	_
13	of	of	ADP	IN	_	_	_	_	_
14	HTLV	HTLV	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
15	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
16	I	I	PRON	PRP	Case=Nom|Number=Sing|Person=1|PronType=Prs	_	_	_	_
17	gene	gene	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
18	expression	expression	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
19	,	,	PUNCT	,	_	_	_	_	_
20	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
21	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
22	viral	viral	ADJ	JJ	Degree=Pos	_	_	_	_
23	oncogene	oncogene	NOUN	NN	Number=Sing	_	_	_	_
24	that	that	PRON	WDT	PronType=Rel	_	_	_	_
25	also	also	ADV	RB	_	_	_	_	_
26	increases	increase	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
27	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
28	of	of	ADP	IN	_	_	_	_	_
29	cellular	cellular	ADJ	JJ	Degree=Pos	_	_	_	_
30	genes	gene	NOUN	NNS	Number=Plur	_	_	_	_
31	including	include	VERB	VBG	VerbForm=Ger	_	_	_	_
32	GM	GM	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
33	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
34	CSF	CSF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
35	,	,	PUNCT	,	_	_	_	_	_
36	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
37	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
38	2R	2R	PROPN	NNP	Number=Sing	_	_	_	_
39	alpha	alpha	PROPN	NNP	Number=Sing	_	_	_	_
40	and	and	CCONJ	CC	_	_	_	_	_
41	IL	il	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
42	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
43	2	2	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
44	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 330
# text = One of the cellular targets of the trans-activating effects of Tax is the NF-kappa B/Rel family of transcription factors, pleiotropic regulators of immunoregulatory, cytokine and viral gene expression.
1	One	one	NUM	CD	NumType=Card	_	_	_	_
2	of	of	ADP	IN	_	_	_	_	_
3	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
4	cellular	cellular	ADJ	JJ	Degree=Pos	_	_	_	_
5	targets	target	NOUN	NNS	Number=Plur	_	_	_	_
6	of	of	ADP	IN	_	_	_	_	_
7	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
8	trans	tran	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
9	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
10	activating	activate	VERB	VBG	VerbForm=Ger	_	_	_	_
11	effects	effect	NOUN	NNS	Number=Plur	_	_	_	_
12	of	of	ADP	IN	_	_	_	_	_
13	Tax	tax	NOUN	NN	Number=Sing	_	_	_	_
14	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
15	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
16	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
17	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
18	kappa	kappa	PROPN	NNP	Number=Sing	_	_	_	_
19	B	b	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
20	/	/	PUNCT	,	_	_	_	_	SpaceAfter=No
21	Rel	Rel	PROPN	NNP	Number=Sing	_	_	_	_
22	family	family	NOUN	NN	Number=Sing	_	_	_	_
23	of	of	ADP	IN	_	_	_	_	_
24	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
25	factors	factor	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
26	,	,	PUNCT	,	_	_	_	_	_
27	pleiotropic	pleiotropic	ADJ	JJ	Degree=Pos	_	_	_	_
28	regulators	regulator	NOUN	NNS	Number=Plur	_	_	_	_
29	of	of	ADP	IN	_	_	_	_	_
30	immunoregulatory	immunoregulatory	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
31	,	,	PUNCT	,	_	_	_	_	_
32	cytokine	cytokine	ADJ	JJ	Degree=Pos	_	_	_	_
33	and	and	CCONJ	CC	_	_	_	_	_
34	viral	viral	ADJ	JJ	Degree=Pos	_	_	_	_
35	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
36	expression	expression	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
37	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 331
# text = In this report, we demonstrate that NFKB2 (lyt-10) and c-Rel are overexpressed in HTLV-I infected and Tax-expressing cells and, together, account for the majority of the constitutive NF-kappa B binding activity in these cells before and after PMA stimulation.
1	In	in	ADP	IN	_	_	_	_	_
2	this	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
3	report	report	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
4	,	,	PUNCT	,	_	_	_	_	_
5	we	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
6	demonstrate	demonstrate	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
7	that	that	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
8	NFKB2	Nfkb2	NOUN	NN	Number=Sing	_	_	_	_
9	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
10	lyt	lyt	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
11	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
12	10	10	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
13	)	)	PUNCT	-RRB-	_	_	_	_	_
14	and	and	CCONJ	CC	_	_	_	_	_
15	c	c	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
16	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
17	Rel	Rel	NOUN	NN	Number=Sing	_	_	_	_
18	are	be	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
19	overexpressed	overexpress	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
20	in	in	ADP	IN	_	_	_	_	_
21	HTLV	HTLV	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
22	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
23	I	I	PRON	PRP	Case=Nom|Number=Sing|Person=1|PronType=Prs	_	_	_	_
24	infected	infect	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
25	and	and	CCONJ	CC	_	_	_	_	_
26	Tax	tax	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
27	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
28	expressing	express	VERB	VBG	VerbForm=Ger	_	_	_	_
29	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
30	and	and	CCONJ	CC	_	_	_	_	SpaceAfter=No
31	,	,	PUNCT	,	_	_	_	_	_
32	together	together	ADV	RB	_	_	_	_	SpaceAfter=No
33	,	,	PUNCT	,	_	_	_	_	_
34	account	account	VERB	VB	Mood=Imp|VerbForm=Fin	_	_	_	_
35	for	for	ADP	IN	_	_	_	_	_
36	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
37	majority	majority	NOUN	NN	Number=Sing	_	_	_	_
38	of	of	ADP	IN	_	_	_	_	_
39	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
40	constitutive	constitutive	ADJ	JJ	Degree=Pos	_	_	_	_
41	NF	Nf	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
42	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
43	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_
44	B	b	NOUN	NN	Number=Sing	_	_	_	_
45	binding	binde	VERB	VBG	VerbForm=Ger	_	_	_	_
46	activity	activity	NOUN	NN	Number=Sing	_	_	_	_
47	in	in	ADP	IN	_	_	_	_	_
48	these	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
49	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
50	before	before	ADP	IN	_	_	_	_	_
51	and	and	CCONJ	CC	_	_	_	_	_
52	after	after	ADP	IN	_	_	_	_	_
53	PMA	Pma	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
54	stimulation	stimulation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
55	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 332
# text = Most importantly, we show a Tax-dependent correlation between expression of NFKB2(p100) and processing to the DNA binding NFKB2(p52) form, induction of c-Rel, and trans-activation of NF-kappa B-mediated gene expression.
1	Most	most	ADV	RBS	_	_	_	_	_
2	importantly	importantly	ADV	RB	_	_	_	_	SpaceAfter=No
3	,	,	PUNCT	,	_	_	_	_	_
4	we	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
5	show	show	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
6	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
7	Tax	tax	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
8	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
9	dependent	dependent	ADJ	JJ	Degree=Pos	_	_	_	_
10	correlation	correlation	NOUN	NN	Number=Sing	_	_	_	_
11	between	between	ADP	IN	_	_	_	_	_
12	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
13	of	of	ADP	IN	_	_	_	_	_
14	NFKB2	NFKB2	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
15	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
16	p100	p100	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
17	)	)	PUNCT	-RRB-	_	_	_	_	_
18	and	and	CCONJ	CC	_	_	_	_	_
19	processing	process	VERB	VBG	VerbForm=Ger	_	_	_	_
20	to	to	ADP	IN	_	_	_	_	_
21	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
22	DNA	dna	NOUN	NN	Number=Sing	_	_	_	_
23	binding	binding	VERB	VBG	VerbForm=Ger	_	_	_	_
24	NFKB2	NFKB2	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
25	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
26	p52	p52	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
27	)	)	PUNCT	-RRB-	_	_	_	_	_
28	form	form	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
29	,	,	PUNCT	,	_	_	_	_	_
30	induction	induction	NOUN	NN	Number=Sing	_	_	_	_
31	of	of	ADP	IN	_	_	_	_	_
32	c	c	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
33	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
34	Rel	Rel	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
35	,	,	PUNCT	,	_	_	_	_	_
36	and	and	CCONJ	CC	_	_	_	_	_
37	trans-	trans-	SYM	NFP	_	_	_	_	SpaceAfter=No
38	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
39	of	of	ADP	IN	_	_	_	_	_
40	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
41	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
42	kappa	kappa	PROPN	NNP	Number=Sing	_	_	_	_
43	B	b	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
44	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
45	mediated	mediate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
46	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
47	expression	expression	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
48	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 333
# text = Furthermore, the NFKB2 precursor is physically associated with c-Rel and with Tax in HTLV-I infected cells.
1	Furthermore	furthermore	ADV	RB	_	_	_	_	SpaceAfter=No
2	,	,	PUNCT	,	_	_	_	_	_
3	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
4	NFKB2	Nfkb2	NOUN	NN	Number=Sing	_	_	_	_
5	precursor	precursor	NOUN	NN	Number=Sing	_	_	_	_
6	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
7	physically	physically	ADV	RB	_	_	_	_	_
8	associated	associate	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
9	with	with	ADP	IN	_	_	_	_	_
10	c-	c-	SYM	NFP	_	_	_	_	SpaceAfter=No
11	Rel	Rel	PROPN	NNP	Number=Sing	_	_	_	_
12	and	and	CCONJ	CC	_	_	_	_	_
13	with	with	ADP	IN	_	_	_	_	_
14	Tax	tax	NOUN	NN	Number=Sing	_	_	_	_
15	in	in	ADP	IN	_	_	_	_	_
16	HTLV	HTLV	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
17	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
18	I	I	PRON	PRP	Case=Nom|Number=Sing|Person=1|PronType=Prs	_	_	_	_
19	infected	infect	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
20	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
21	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 334
# text = We propose that NFKB2 synthesis and processing allows continuous nuclear expression of an otherwise cytoplasmic protein and, in conjunction with overexpression of c-Rel, NFKB2 alters the NF-kappa B signalling pathway and contributes to leukemic transformation of T cells by HTLV-I.
1	We	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
2	propose	propose	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
3	that	that	SCONJ	IN	_	_	_	_	_
4	NFKB2	Nfkb2	NUM	CD	NumType=Card	_	_	_	_
5	synthesis	synthesis	NOUN	NN	Number=Sing	_	_	_	_
6	and	and	CCONJ	CC	_	_	_	_	_
7	processing	processing	VERB	VBG	VerbForm=Ger	_	_	_	_
8	allows	allow	NOUN	NNS	Number=Plur	_	_	_	_
9	continuous	continuous	ADJ	JJ	Degree=Pos	_	_	_	_
10	nuclear	nuclear	ADJ	JJ	Degree=Pos	_	_	_	_
11	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
12	of	of	ADP	IN	_	_	_	_	_
13	an	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
14	otherwise	otherwise	ADV	RB	_	_	_	_	_
15	cytoplasmic	cytoplasmic	ADJ	JJ	Degree=Pos	_	_	_	_
16	protein	protein	NOUN	NN	Number=Sing	_	_	_	_
17	and	and	CCONJ	CC	_	_	_	_	SpaceAfter=No
18	,	,	PUNCT	,	_	_	_	_	_
19	in	in	ADP	IN	_	_	_	_	_
20	conjunction	conjunction	NOUN	NN	Number=Sing	_	_	_	_
21	with	with	ADP	IN	_	_	_	_	_
22	overexpression	overexpression	NOUN	NN	Number=Sing	_	_	_	_
23	of	of	ADP	IN	_	_	_	_	_
24	c	c	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
25	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
26	Rel	Rel	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
27	,	,	PUNCT	,	_	_	_	_	_
28	NFKB2	NFKB2	NUM	CD	NumType=Card	_	_	_	_
29	alters	alter	NOUN	NNS	Number=Plur	_	_	_	_
30	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
31	NF	Nf	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
32	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
33	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_
34	B	b	NOUN	NN	Number=Sing	_	_	_	_
35	signalling	signall	VERB	VBG	VerbForm=Ger	_	_	_	_
36	pathway	pathway	NOUN	NN	Number=Sing	_	_	_	_
37	and	and	CCONJ	CC	_	_	_	_	_
38	contributes	contribute	NOUN	NNS	Number=Plur	_	_	_	_
39	to	to	ADP	IN	_	_	_	_	_
40	leukemic	leukemic	ADJ	JJ	Degree=Pos	_	_	_	_
41	transformation	transformation	NOUN	NN	Number=Sing	_	_	_	_
42	of	of	ADP	IN	_	_	_	_	_
43	T	t	PROPN	NNP	Number=Sing	_	_	_	_
44	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
45	by	by	ADP	IN	_	_	_	_	_
46	HTLV	HTLV	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
47	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
48	I	I	PRON	PRP	Case=Nom|Number=Sing|Person=1|PronType=Prs	_	_	_	SpaceAfter=No
49	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 335
# text = Document 003002124 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	003002124	003002124	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 336
# text = Abnormal regulation of the IL-2 promoter in lpr CD4-CD8- T lymphocytes results in constitutive expression of a novel nuclear factor of activated T cells-binding factor.
1	Abnormal	abnormal	ADJ	JJ	Degree=Pos	_	_	_	_
2	regulation	regulation	NOUN	NN	Number=Sing	_	_	_	_
3	of	of	ADP	IN	_	_	_	_	_
4	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
5	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
6	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
7	2	2	NUM	CD	NumType=Card	_	_	_	_
8	promoter	promoter	NOUN	NN	Number=Sing	_	_	_	_
9	in	in	ADP	IN	_	_	_	_	_
10	lpr	lpr	ADJ	JJ	Degree=Pos	_	_	_	_
11	CD4-CD8	CD4-CD8	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
12	-	-	PUNCT	HYPH	_	_	_	_	_
13	T	T	PROPN	NNP	Number=Sing	_	_	_	_
14	lymphocytes	lymphocyte	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
15	results	result	NOUN	NNS	Number=Plur	_	_	_	_
16	in	in	ADP	IN	_	_	_	_	_
17	constitutive	constitutive	ADJ	JJ	Degree=Pos	_	_	_	_
18	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
19	of	of	ADP	IN	_	_	_	_	_
20	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
21	novel	novel	NOUN	NN	Number=Sing	_	_	_	_
22	nuclear	nuclear	ADJ	JJ	Degree=Pos	_	_	_	_
23	factor	factor	NOUN	NN	Number=Sing	_	_	_	_
24	of	of	ADP	IN	_	_	_	_	_
25	activated	activate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
26	T	t	PROPN	NNP	Number=Sing	_	_	_	_
27	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
28	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
29	binding	bind	VERB	VBG	VerbForm=Ger	_	_	_	_
30	factor	factor	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
31	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 337
# text = The inert quality of MRL-Ipr/Ipr (Ipr) peripheral CD4-CD8- (CD4-8-) T cells manifests primarily as an inability to proliferate or produce IL-2 in response to TCR or mitogenic stimulation.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	inert	inert	ADJ	JJ	Degree=Pos	_	_	_	_
3	quality	quality	NOUN	NN	Number=Sing	_	_	_	_
4	of	of	ADP	IN	_	_	_	_	_
5	MRL	MRL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
6	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
7	Ipr	Ipr	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
8	/	/	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
9	Ipr	Ipr	PROPN	NNP	Number=Sing	_	_	_	_
10	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
11	Ipr	Ipr	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
12	)	)	PUNCT	-RRB-	_	_	_	_	_
13	peripheral	peripheral	ADJ	JJ	Degree=Pos	_	_	_	_
14	CD4-CD8	Cd4-cd8	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
15	-	-	PUNCT	,	_	_	_	_	_
16	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
17	CD4	CD4	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
18	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
19	8-)	8-)	SYM	NFP	_	_	_	_	_
20	T	t	PROPN	NNP	Number=Sing	_	_	_	_
21	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
22	manifests	manifest	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
23	primarily	primarily	ADV	RB	_	_	_	_	_
24	as	as	ADP	IN	_	_	_	_	_
25	an	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
26	inability	inability	NOUN	NN	Number=Sing	_	_	_	_
27	to	to	PART	TO	_	_	_	_	_
28	proliferate	proliferate	VERB	VB	VerbForm=Inf	_	_	_	_
29	or	or	CCONJ	CC	_	_	_	_	_
30	produce	produce	VERB	VB	VerbForm=Inf	_	_	_	_
31	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
32	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
33	2	2	NUM	CD	NumType=Card	_	_	_	_
34	in	in	ADP	IN	_	_	_	_	_
35	response	response	NOUN	NN	Number=Sing	_	_	_	_
36	to	to	ADP	IN	_	_	_	_	_
37	TCR	TCR	PROPN	NNP	Number=Sing	_	_	_	_
38	or	or	CCONJ	CC	_	_	_	_	_
39	mitogenic	mitogenic	ADJ	JJ	Degree=Pos	_	_	_	_
40	stimulation	stimulation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
41	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 338
# text = Yet these same cells do initiate early TCR-mediated signaling events, such as generation of inositol phosphates and increased intracellular calcium.
1	Yet	yet	CCONJ	CC	_	_	_	_	_
2	these	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
3	same	same	ADJ	JJ	Degree=Pos	_	_	_	_
4	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
5	do	do	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
6	initiate	initiate	VERB	VB	VerbForm=Inf	_	_	_	_
7	early	early	ADV	RB	Degree=Pos	_	_	_	_
8	TCR	TCR	ADV	RBR	Degree=Cmp	_	_	_	SpaceAfter=No
9	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
10	mediated	mediate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
11	signaling	signaling	NOUN	NN	Number=Sing	_	_	_	_
12	events	event	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
13	,	,	PUNCT	,	_	_	_	_	_
14	such	such	ADJ	JJ	Degree=Pos	_	_	_	_
15	as	as	ADP	IN	_	_	_	_	_
16	generation	generation	NOUN	NN	Number=Sing	_	_	_	_
17	of	of	ADP	IN	_	_	_	_	_
18	inositol	inositol	ADJ	JJ	Degree=Pos	_	_	_	_
19	phosphates	phosphate	NOUN	NNS	Number=Plur	_	_	_	_
20	and	and	CCONJ	CC	_	_	_	_	_
21	increased	increase	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
22	intracellular	intracellular	ADJ	JJ	Degree=Pos	_	_	_	_
23	calcium	calcium	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
24	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 339
# text = They also display constitutively high levels of p59fyn and CD3 zeta tyrosine phosphorylation.
1	They	they	PRON	PRP	Case=Nom|Number=Plur|Person=3|PronType=Prs	_	_	_	_
2	also	also	ADV	RB	_	_	_	_	_
3	display	display	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
4	constitutively	constitutively	ADV	RB	_	_	_	_	_
5	high	high	ADJ	JJ	Degree=Pos	_	_	_	_
6	levels	level	NOUN	NNS	Number=Plur	_	_	_	_
7	of	of	ADP	IN	_	_	_	_	_
8	p5	p5	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
9	9fyn	9fyn	NOUN	NN	Number=Sing	_	_	_	_
10	and	and	CCONJ	CC	_	_	_	_	_
11	CD3	CD3	NUM	CD	NumType=Card	_	_	_	_
12	zeta	zeta	NOUN	NN	Number=Sing	_	_	_	_
13	tyrosine	tyrosine	NOUN	NN	Number=Sing	_	_	_	_
14	phosphorylation	phosphorylation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
15	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 340
# text = The generation of second messengers in T cells normally leads to downstream signaling that results in transcriptional activation of the IL-2 gene.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	generation	generation	NOUN	NN	Number=Sing	_	_	_	_
3	of	of	ADP	IN	_	_	_	_	_
4	second	second	ADJ	JJ	Degree=Pos|NumType=Ord	_	_	_	_
5	messengers	messenger	NOUN	NNS	Number=Plur	_	_	_	_
6	in	in	ADP	IN	_	_	_	_	_
7	T	t	PROPN	NNP	Number=Sing	_	_	_	_
8	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
9	normally	normally	ADV	RB	_	_	_	_	_
10	leads	lead	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
11	to	to	PART	TO	_	_	_	_	_
12	downstream	downstream	VERB	VB	VerbForm=Inf	_	_	_	_
13	signaling	signal	VERB	VBG	VerbForm=Ger	_	_	_	_
14	that	that	SCONJ	IN	_	_	_	_	_
15	results	result	NOUN	NNS	Number=Plur	_	_	_	_
16	in	in	ADP	IN	_	_	_	_	_
17	transcriptional	transcriptional	ADJ	JJ	Degree=Pos	_	_	_	_
18	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
19	of	of	ADP	IN	_	_	_	_	_
20	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
21	IL	Il	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
22	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
23	2	2	NUM	CD	NumType=Card	_	_	_	_
24	gene	gene	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
25	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 341
# text = We, therefore, compared the activation state of the IL-2 gene promoter region in freshly isolated and stimulated Ipr CD4-8- T cells with that of normal T lymphocytes.
1	We	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	SpaceAfter=No
2	,	,	PUNCT	,	_	_	_	_	_
3	therefore	therefore	ADV	RB	_	_	_	_	SpaceAfter=No
4	,	,	PUNCT	,	_	_	_	_	_
5	compared	compare	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
6	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
7	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
8	state	state	NOUN	NN	Number=Sing	_	_	_	_
9	of	of	ADP	IN	_	_	_	_	_
10	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
11	IL	Il	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
12	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
13	2	2	NUM	CD	NumType=Card	_	_	_	_
14	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
15	promoter	promoter	NOUN	NN	Number=Sing	_	_	_	_
16	region	region	NOUN	NN	Number=Sing	_	_	_	_
17	in	in	ADP	IN	_	_	_	_	_
18	freshly	freshly	ADV	RB	_	_	_	_	_
19	isolated	isolate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
20	and	and	CCONJ	CC	_	_	_	_	_
21	stimulated	stimulate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
22	Ipr	Ipr	PROPN	NNP	Number=Sing	_	_	_	_
23	CD4	CD4	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
24	-8	-8	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
25	-	-	PUNCT	HYPH	_	_	_	_	_
26	T	t	NOUN	NN	Number=Sing	_	_	_	_
27	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
28	with	with	ADP	IN	_	_	_	_	_
29	that	that	PRON	DT	Number=Sing|PronType=Dem	_	_	_	_
30	of	of	ADP	IN	_	_	_	_	_
31	normal	normal	ADJ	JJ	Degree=Pos	_	_	_	_
32	T	T	PROPN	NNP	Number=Sing	_	_	_	_
33	lymphocytes	lymphocyte	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
34	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 342
# text = Levels of the octamer, NF-kappa B (p50-p65 heterodimer), and AP-1 transcriptional factors are constitutively elevated in freshly isolated Ipr CD4-8- T cells, consistent with the activated phenotype of these cells.
1	Levels	level	NOUN	NNS	Number=Plur	_	_	_	_
2	of	of	ADP	IN	_	_	_	_	_
3	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
4	octamer	octamer	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
5	,	,	PUNCT	,	_	_	_	_	_
6	NF	NF	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
7	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
8	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_
9	B	B	NOUN	NN	Number=Sing	_	_	_	_
10	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
11	p50	p50	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
12	-	-	SYM	SYM	_	_	_	_	SpaceAfter=No
13	p65	p65	NUM	CD	NumType=Card	_	_	_	_
14	heterodimer	heterodimer	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
15	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
16	,	,	PUNCT	,	_	_	_	_	_
17	and	and	CCONJ	CC	_	_	_	_	_
18	AP	ap	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
19	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
20	1	1	NUM	CD	NumType=Card	_	_	_	_
21	transcriptional	transcriptional	ADJ	JJ	Degree=Pos	_	_	_	_
22	factors	factor	NOUN	NNS	Number=Plur	_	_	_	_
23	are	be	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
24	constitutively	constitutively	ADV	RB	_	_	_	_	_
25	elevated	elevate	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
26	in	in	ADP	IN	_	_	_	_	_
27	freshly	freshly	ADV	RB	_	_	_	_	_
28	isolated	isolate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
29	Ipr	Ipr	PROPN	NNP	Number=Sing	_	_	_	_
30	CD4	CD4	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
31	-8	-8	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
32	-	-	PUNCT	HYPH	_	_	_	_	_
33	T	t	NOUN	NN	Number=Sing	_	_	_	_
34	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
35	,	,	PUNCT	,	_	_	_	_	_
36	consistent	consistent	ADJ	JJ	Degree=Pos	_	_	_	_
37	with	with	ADP	IN	_	_	_	_	_
38	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
39	activated	activated	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
40	phenotype	phenotype	NOUN	NN	Number=Sing	_	_	_	_
41	of	of	ADP	IN	_	_	_	_	_
42	these	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
43	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
44	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 343
# text = Upon stimulation with mitogens, formation of the transactivating complex, nuclear factor of activated T cells (NF-AT), occurs with normal kinetics in Ipr CD4-8- T cells.
1	Upon	upon	ADP	IN	_	_	_	_	_
2	stimulation	stimulation	NOUN	NN	Number=Sing	_	_	_	_
3	with	with	ADP	IN	_	_	_	_	_
4	mitogens	mitogen	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
5	,	,	PUNCT	,	_	_	_	_	_
6	formation	formation	NOUN	NN	Number=Sing	_	_	_	_
7	of	of	ADP	IN	_	_	_	_	_
8	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
9	transactivating	transactivating	VERB	VBG	VerbForm=Ger	_	_	_	_
10	complex	complex	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
11	,	,	PUNCT	,	_	_	_	_	_
12	nuclear	nuclear	ADJ	JJ	Degree=Pos	_	_	_	_
13	factor	factor	NOUN	NN	Number=Sing	_	_	_	_
14	of	of	ADP	IN	_	_	_	_	_
15	activated	activated	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
16	T	T	PROPN	NNP	Number=Sing	_	_	_	_
17	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
18	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
19	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
20	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
21	AT	AT	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
22	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
23	,	,	PUNCT	,	_	_	_	_	_
24	occurs	occur	NOUN	NNS	Number=Plur	_	_	_	_
25	with	with	ADP	IN	_	_	_	_	_
26	normal	normal	ADJ	JJ	Degree=Pos	_	_	_	_
27	kinetics	kinetic	NOUN	NNS	Number=Plur	_	_	_	_
28	in	in	ADP	IN	_	_	_	_	_
29	Ipr	Ipr	PROPN	NNP	Number=Sing	_	_	_	_
30	CD4	CD4	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
31	-8	-8	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
32	-	-	PUNCT	HYPH	_	_	_	_	_
33	T	t	NOUN	NN	Number=Sing	_	_	_	_
34	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
35	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 344
# text = Yet, the levels of the activating NF-AT complex never reach those observed in similarly stimulated normal T cells.
1	Yet	yet	CCONJ	CC	_	_	_	_	SpaceAfter=No
2	,	,	PUNCT	,	_	_	_	_	_
3	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
4	levels	level	NOUN	NNS	Number=Plur	_	_	_	_
5	of	of	ADP	IN	_	_	_	_	_
6	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
7	activating	activate	VERB	VBG	VerbForm=Ger	_	_	_	_
8	NF	NF	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
9	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
10	AT	AT	NOUN	NN	Number=Sing	_	_	_	_
11	complex	complex	NOUN	NN	Number=Sing	_	_	_	_
12	never	never	ADV	RB	_	_	_	_	_
13	reach	reach	VERB	VB	VerbForm=Inf	_	_	_	_
14	those	those	PRON	DT	Number=Plur|PronType=Dem	_	_	_	_
15	observed	observe	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
16	in	in	ADV	RB	_	_	_	_	_
17	similarly	similarly	ADV	RB	_	_	_	_	_
18	stimulated	stimulate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
19	normal	normal	ADJ	JJ	Degree=Pos	_	_	_	_
20	T	t	PROPN	NNP	Number=Sing	_	_	_	_
21	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
22	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 345
# text = Furthermore, nuclear extracts from Ipr CD4-8- T cells display high levels of a novel specific binding activity at the NF-AT site, which is present at much lower levels in freshly isolated normal T lymphocytes.
1	Furthermore	furthermore	ADV	RB	_	_	_	_	SpaceAfter=No
2	,	,	PUNCT	,	_	_	_	_	_
3	nuclear	nuclear	ADJ	JJ	Degree=Pos	_	_	_	_
4	extracts	extract	NOUN	NNS	Number=Plur	_	_	_	_
5	from	from	ADP	IN	_	_	_	_	_
6	Ipr	Ipr	PROPN	NNP	Number=Sing	_	_	_	_
7	CD4	CD4	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
8	-8	-8	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
9	-	-	SYM	SYM	_	_	_	_	_
10	T	t	NUM	CD	NumType=Card	_	_	_	_
11	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
12	display	display	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
13	high	high	ADJ	JJ	Degree=Pos	_	_	_	_
14	levels	level	NOUN	NNS	Number=Plur	_	_	_	_
15	of	of	ADP	IN	_	_	_	_	_
16	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
17	novel	novel	NOUN	NN	Number=Sing	_	_	_	_
18	specific	specific	ADJ	JJ	Degree=Pos	_	_	_	_
19	binding	bind	VERB	VBG	VerbForm=Ger	_	_	_	_
20	activity	activity	NOUN	NN	Number=Sing	_	_	_	_
21	at	at	ADP	IN	_	_	_	_	_
22	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
23	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
24	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
25	AT	AT	PROPN	NNP	Number=Sing	_	_	_	_
26	site	site	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
27	,	,	PUNCT	,	_	_	_	_	_
28	which	which	PRON	WDT	PronType=Rel	_	_	_	_
29	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
30	present	present	ADJ	JJ	Degree=Pos	_	_	_	_
31	at	at	ADP	IN	_	_	_	_	_
32	much	much	ADV	RB	_	_	_	_	_
33	lower	lower	ADJ	JJR	Degree=Cmp	_	_	_	_
34	levels	level	NOUN	NNS	Number=Plur	_	_	_	_
35	in	in	ADP	IN	_	_	_	_	_
36	freshly	freshly	ADV	RB	_	_	_	_	_
37	isolated	isolate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
38	normal	normal	ADJ	JJ	Degree=Pos	_	_	_	_
39	T	t	NOUN	NN	Number=Sing	_	_	_	_
40	lymphocytes	lymphocyte	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
41	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 346
# text = Upon mitogenic stimulation, the binding activity of the novel NF-AT-binding factor is rapidly down-regulated in normal T cells, but persists at high levels in Ipr CD4-8- T cells.
1	Upon	upon	ADP	IN	_	_	_	_	_
2	mitogenic	mitogenic	ADJ	JJ	Degree=Pos	_	_	_	_
3	stimulation	stimulation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
4	,	,	PUNCT	,	_	_	_	_	_
5	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
6	binding	bind	VERB	VBG	VerbForm=Ger	_	_	_	_
7	activity	activity	NOUN	NN	Number=Sing	_	_	_	_
8	of	of	ADP	IN	_	_	_	_	_
9	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
10	novel	novel	PROPN	NNP	Number=Sing	_	_	_	_
11	NF	Nf	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
12	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
13	AT	At	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
14	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
15	binding	binding	VERB	VBG	VerbForm=Ger	_	_	_	_
16	factor	factor	NOUN	NN	Number=Sing	_	_	_	_
17	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
18	rapidly	rapidly	ADV	RB	_	_	_	_	_
19	down	down	ADV	RB	_	_	_	_	SpaceAfter=No
20	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
21	regulated	regulate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
22	in	in	ADP	IN	_	_	_	_	_
23	normal	normal	ADJ	JJ	Degree=Pos	_	_	_	_
24	T	T	PROPN	NNP	Number=Sing	_	_	_	_
25	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
26	,	,	PUNCT	,	_	_	_	_	_
27	but	but	CCONJ	CC	_	_	_	_	_
28	persists	persist	NOUN	NNS	Number=Plur	_	_	_	_
29	at	at	ADP	IN	_	_	_	_	_
30	high	high	ADJ	JJ	Degree=Pos	_	_	_	_
31	levels	level	NOUN	NNS	Number=Plur	_	_	_	_
32	in	in	ADP	IN	_	_	_	_	_
33	Ipr	Ipr	PROPN	NNP	Number=Sing	_	_	_	_
34	CD4	CD4	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
35	-8	-8	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
36	-	-	PUNCT	HYPH	_	_	_	_	_
37	T	t	NOUN	NN	Number=Sing	_	_	_	_
38	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
39	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 347
# text = These two abnormalities at the NF-AT site provide a potential mechanism to account for the defect in IL-2 production from Ipr CD4-8- T cells.
1	These	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
2	two	two	NUM	CD	NumType=Card	_	_	_	_
3	abnormalities	abnormality	NOUN	NNS	Number=Plur	_	_	_	_
4	at	at	ADP	IN	_	_	_	_	_
5	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
6	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
7	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
8	AT	AT	PROPN	NNP	Number=Sing	_	_	_	_
9	site	site	NOUN	NN	Number=Sing	_	_	_	_
10	provide	provide	VERB	VB	VerbForm=Inf	_	_	_	_
11	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
12	potential	potential	ADJ	JJ	Degree=Pos	_	_	_	_
13	mechanism	mechanism	NOUN	NN	Number=Sing	_	_	_	_
14	to	to	PART	TO	_	_	_	_	_
15	account	account	VERB	VB	VerbForm=Inf	_	_	_	_
16	for	for	ADP	IN	_	_	_	_	_
17	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
18	defect	defect	NOUN	NN	Number=Sing	_	_	_	_
19	in	in	ADP	IN	_	_	_	_	_
20	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
21	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
22	2	2	NUM	CD	NumType=Card	_	_	_	_
23	production	production	NOUN	NN	Number=Sing	_	_	_	_
24	from	from	ADP	IN	_	_	_	_	_
25	Ipr	Ipr	PROPN	NNP	Number=Sing	_	_	_	_
26	CD4	CD4	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
27	-8	-8	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
28	-	-	PUNCT	HYPH	_	_	_	_	_
29	T	t	NOUN	NN	Number=Sing	_	_	_	_
30	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
31	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 348
# text = Document 003002127 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	003002127	003002127	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 349
# text = IL-2-induced growth of CD8+ T cell prolymphocytic leukemia cells mediated by NF-kappaB induction and IL-2 receptor alpha expression.
1	IL	Il	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
2	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
3	2	2	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
4	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
5	induced	induce	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
6	growth	growth	NOUN	NN	Number=Sing	_	_	_	_
7	of	of	ADP	IN	_	_	_	_	_
8	CD8	CD8	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
9	+	+	SYM	SYM	_	_	_	_	_
10	T	t	PROPN	NNP	Number=Sing	_	_	_	_
11	cell	cell	PROPN	NNP	Number=Sing	_	_	_	_
12	prolymphocytic	prolymphocytic	ADJ	JJ	Degree=Pos	_	_	_	_
13	leukemia	leukemia	NOUN	NN	Number=Sing	_	_	_	_
14	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
15	mediated	mediate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
16	by	by	ADP	IN	_	_	_	_	_
17	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
18	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
19	kappaB	kappaB	PROPN	NNP	Number=Sing	_	_	_	_
20	induction	induction	NOUN	NN	Number=Sing	_	_	_	_
21	and	and	CCONJ	CC	_	_	_	_	_
22	IL	Il	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
23	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
24	2	2	NUM	CD	NumType=Card	_	_	_	_
25	receptor	receptor	NOUN	NN	Number=Sing	_	_	_	_
26	alpha	alpha	NOUN	NN	Number=Sing	_	_	_	_
27	expression	expression	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
28	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 350
# text = The binding of interleukin-2 (IL-2) to its receptor on normal T cells induces nuclear expression of nuclear factor kappaB (NF-kappaB), activation of the IL-2 receptor (IL-2R) alpha chain gene, and cell proliferation.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	binding	binding	NOUN	NN	Number=Sing	_	_	_	_
3	of	of	ADP	IN	_	_	_	_	_
4	interleukin	interleukin	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
5	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
6	2	2	NUM	CD	NumType=Card	_	_	_	_
7	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
8	IL	Il	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
9	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
10	2	2	X	LS	_	_	_	_	SpaceAfter=No
11	)	)	PUNCT	-RRB-	_	_	_	_	_
12	to	to	ADP	IN	_	_	_	_	_
13	its	its	PRON	PRP$	Gender=Neut|Number=Sing|Person=3|Poss=Yes|PronType=Prs	_	_	_	_
14	receptor	receptor	NOUN	NN	Number=Sing	_	_	_	_
15	on	on	ADP	IN	_	_	_	_	_
16	normal	normal	ADJ	JJ	Degree=Pos	_	_	_	_
17	T	t	PROPN	NNP	Number=Sing	_	_	_	_
18	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
19	induces	induce	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
20	nuclear	nuclear	ADJ	JJ	Degree=Pos	_	_	_	_
21	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
22	of	of	ADP	IN	_	_	_	_	_
23	nuclear	nuclear	ADJ	JJ	Degree=Pos	_	_	_	_
24	factor	factor	NOUN	NN	Number=Sing	_	_	_	_
25	kappaB	kappaB	PROPN	NNP	Number=Sing	_	_	_	_
26	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
27	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
28	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
29	kappaB	kappaB	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
30	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
31	,	,	PUNCT	,	_	_	_	_	_
32	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
33	of	of	ADP	IN	_	_	_	_	_
34	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
35	IL	Il	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
36	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
37	2	2	NUM	CD	NumType=Card	_	_	_	_
38	receptor	receptor	NOUN	NN	Number=Sing	_	_	_	_
39	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
40	IL	Il	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
41	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
42	2R	2r	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
43	)	)	PUNCT	-RRB-	_	_	_	_	_
44	alpha	alpha	NOUN	NN	Number=Sing	_	_	_	_
45	chain	chain	NOUN	NN	Number=Sing	_	_	_	_
46	gene	gene	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
47	,	,	PUNCT	,	_	_	_	_	_
48	and	and	CCONJ	CC	_	_	_	_	_
49	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
50	proliferation	proliferation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
51	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 351
# text = In the present study, the role of IL-2R signaling in the growth of CD8+ T cell prolymphocytic leukemia (T-PLL) cells has been investigated.
1	In	in	ADP	IN	_	_	_	_	_
2	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
3	present	present	ADJ	JJ	Degree=Pos	_	_	_	_
4	study	study	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
5	,	,	PUNCT	,	_	_	_	_	_
6	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
7	role	role	NOUN	NN	Number=Sing	_	_	_	_
8	of	of	ADP	IN	_	_	_	_	_
9	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
10	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
11	2	2	X	LS	_	_	_	_	SpaceAfter=No
12	R	be	X	GW	_	_	_	_	_
13	signaling	signal	NOUN	NN	Number=Sing	_	_	_	_
14	in	in	ADP	IN	_	_	_	_	_
15	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
16	growth	growth	NOUN	NN	Number=Sing	_	_	_	_
17	of	of	ADP	IN	_	_	_	_	_
18	CD8	CD8	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
19	+	+	SYM	SYM	_	_	_	_	_
20	T	t	NUM	CD	NumType=Card	_	_	_	_
21	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
22	prolymphocytic	prolymphocytic	ADJ	JJ	Degree=Pos	_	_	_	_
23	leukemia	leukemia	NOUN	NN	Number=Sing	_	_	_	_
24	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
25	T	t	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
26	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
27	PLL	pLl	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
28	)	)	PUNCT	-RRB-	_	_	_	_	_
29	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
30	has	have	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
31	been	be	AUX	VBN	Tense=Past|VerbForm=Part	_	_	_	_
32	investigated	investigate	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	SpaceAfter=No
33	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 352
# text = Flow cytometry revealed that primary leukemia cells from a patient with CD8+ T-PLL expressed IL-2Ralpha and beta chains, and the cells showed a proliferative response and an increase in IL-2Ralpha expression on culture with exogeneous IL-2.
1	Flow	flow	ADJ	JJ	Degree=Pos	_	_	_	_
2	cytometry	cytometry	NOUN	NN	Number=Sing	_	_	_	_
3	revealed	reveal	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
4	that	that	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
5	primary	primary	ADJ	JJ	Degree=Pos	_	_	_	_
6	leukemia	leukemia	NOUN	NN	Number=Sing	_	_	_	_
7	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
8	from	from	ADP	IN	_	_	_	_	_
9	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
10	patient	patient	NOUN	NN	Number=Sing	_	_	_	_
11	with	with	ADP	IN	_	_	_	_	_
12	CD8	CD8	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
13	+	+	SYM	SYM	_	_	_	_	_
14	T	t	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
15	-	-	PUNCT	:	_	_	_	_	SpaceAfter=No
16	PLL	pLl	NOUN	NN	Number=Sing	_	_	_	_
17	expressed	express	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
18	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
19	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
20	2	2	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
21	Ralpha	Ralpha	NOUN	NN	Number=Sing	_	_	_	_
22	and	and	CCONJ	CC	_	_	_	_	_
23	beta	beta	NOUN	NN	Number=Sing	_	_	_	_
24	chains	chains	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
25	,	,	PUNCT	,	_	_	_	_	_
26	and	and	CCONJ	CC	_	_	_	_	_
27	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
28	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
29	showed	show	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
30	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
31	proliferative	proliferative	ADJ	JJ	Degree=Pos	_	_	_	_
32	response	response	NOUN	NN	Number=Sing	_	_	_	_
33	and	and	CCONJ	CC	_	_	_	_	_
34	an	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
35	increase	increase	NOUN	NN	Number=Sing	_	_	_	_
36	in	in	ADP	IN	_	_	_	_	_
37	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
38	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
39	2	2	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
40	Ralpha	Ralpha	PROPN	NNP	Number=Sing	_	_	_	_
41	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
42	on	on	ADP	IN	_	_	_	_	_
43	culture	culture	NOUN	NN	Number=Sing	_	_	_	_
44	with	with	ADP	IN	_	_	_	_	_
45	exogeneous	exogeneous	ADJ	JJ	Degree=Pos	_	_	_	_
46	IL	il	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
47	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
48	2	2	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
49	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 353
# text = Northern blot analysis failed to detect IL-2 mRNA, suggesting that IL-2 may act in a paracrine manner in vivo.
1	Northern	Northern	ADJ	JJ	Degree=Pos	_	_	_	_
2	blot	blot	NOUN	NN	Number=Sing	_	_	_	_
3	analysis	analysis	NOUN	NN	Number=Sing	_	_	_	_
4	failed	fail	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
5	to	to	PART	TO	_	_	_	_	_
6	detect	detect	VERB	VB	VerbForm=Inf	_	_	_	_
7	IL	Il	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
8	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
9	2	2	NUM	CD	NumType=Card	_	_	_	_
10	mRNA	mRNa	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
11	,	,	PUNCT	,	_	_	_	_	_
12	suggesting	suggest	VERB	VBG	VerbForm=Ger	_	_	_	_
13	that	that	SCONJ	IN	_	_	_	_	_
14	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
15	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
16	2	2	NUM	CD	NumType=Card	_	_	_	_
17	may	may	AUX	MD	VerbForm=Fin	_	_	_	_
18	act	act	VERB	VB	VerbForm=Inf	_	_	_	_
19	in	in	ADP	IN	_	_	_	_	_
20	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
21	paracrine	paracrine	NOUN	NN	Number=Sing	_	_	_	_
22	manner	manner	NOUN	NN	Number=Sing	_	_	_	_
23	in	in	ADP	IN	_	_	_	_	_
24	vivo.	vivo.	NOUN	NN	Number=Sing	_	_	_	_

# sent_id = 354
# text = Electrophoretic mobility-shift assays revealed that recombinant IL-2 increased NF-kappaB binding activity in nuclear extracts of the leukemia cells, and Northern blot analysis showed that IL-2 increased the abundance of mRNAs encoding the NF-kappaB components c-Rel and KBF1 in these cells.
1	Electrophoretic	Electrophoretic	ADJ	JJ	Degree=Pos	_	_	_	_
2	mobility	mobility	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
3	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
4	shift	shift	NOUN	NN	Number=Sing	_	_	_	_
5	assays	assay	NOUN	NNS	Number=Plur	_	_	_	_
6	revealed	reveal	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
7	that	that	SCONJ	IN	_	_	_	_	_
8	recombinant	recombinant	ADJ	JJ	Degree=Pos	_	_	_	_
9	IL	Il	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
10	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
11	2	2	NUM	CD	NumType=Card	_	_	_	_
12	increased	increase	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
13	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
14	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
15	kappaB	kappaB	PROPN	NNP	Number=Sing	_	_	_	_
16	binding	bind	VERB	VBG	VerbForm=Ger	_	_	_	_
17	activity	activity	NOUN	NN	Number=Sing	_	_	_	_
18	in	in	ADP	IN	_	_	_	_	_
19	nuclear	nuclear	ADJ	JJ	Degree=Pos	_	_	_	_
20	extracts	extract	NOUN	NNS	Number=Plur	_	_	_	_
21	of	of	ADP	IN	_	_	_	_	_
22	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
23	leukemia	leukemia	NOUN	NN	Number=Sing	_	_	_	_
24	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
25	,	,	PUNCT	,	_	_	_	_	_
26	and	and	CCONJ	CC	_	_	_	_	_
27	Northern	Northern	ADJ	JJ	Degree=Pos	_	_	_	_
28	blot	blot	NOUN	NN	Number=Sing	_	_	_	_
29	analysis	analysis	NOUN	NN	Number=Sing	_	_	_	_
30	showed	show	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
31	that	that	SCONJ	IN	_	_	_	_	_
32	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
33	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
34	2	2	NUM	CD	NumType=Card	_	_	_	_
35	increased	increase	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
36	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
37	abundance	abundance	NOUN	NN	Number=Sing	_	_	_	_
38	of	of	ADP	IN	_	_	_	_	_
39	mRNAs	mRNA	SCONJ	IN	_	_	_	_	_
40	encoding	encod	VERB	VBG	VerbForm=Ger	_	_	_	_
41	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
42	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
43	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
44	kappaB	kappaB	PROPN	NNP	Number=Sing	_	_	_	_
45	components	component	NOUN	NNS	Number=Plur	_	_	_	_
46	c-	c-	SYM	NFP	_	_	_	_	SpaceAfter=No
47	Rel	Rel	PROPN	NNP	Number=Sing	_	_	_	_
48	and	and	CCONJ	CC	_	_	_	_	_
49	KBF1	KBF1	PROPN	NNP	Number=Sing	_	_	_	_
50	in	in	ADP	IN	_	_	_	_	_
51	these	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
52	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
53	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 355
# text = IL-2 binding analysis demonstrated that IL-2 markedly increased the number of low affinity IL-2Rs on the leukemia cells, without an effect on the number of high-affinity IL-2Rs.
1	IL	Il	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
2	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
3	2	2	NUM	CD	NumType=Card	_	_	_	_
4	binding	binding	VERB	VBG	VerbForm=Ger	_	_	_	_
5	analysis	analysis	NOUN	NN	Number=Sing	_	_	_	_
6	demonstrated	demonstrate	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
7	that	that	SCONJ	IN	_	_	_	_	_
8	IL	Il	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
9	-	-	SYM	SYM	_	_	_	_	SpaceAfter=No
10	2	2	NUM	CD	NumType=Card	_	_	_	_
11	markedly	markedly	ADV	RB	_	_	_	_	_
12	increased	increase	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
13	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
14	number	number	NOUN	NN	Number=Sing	_	_	_	_
15	of	of	ADP	IN	_	_	_	_	_
16	low	low	ADJ	JJ	Degree=Pos	_	_	_	_
17	affinity	affinity	NOUN	NN	Number=Sing	_	_	_	_
18	IL	Il	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
19	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
20	2	2	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
21	Rs	R	NOUN	NNS	Number=Plur	_	_	_	_
22	on	on	ADP	IN	_	_	_	_	_
23	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
24	leukemia	leukemia	NOUN	NN	Number=Sing	_	_	_	_
25	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
26	,	,	PUNCT	,	_	_	_	_	_
27	without	without	ADP	IN	_	_	_	_	_
28	an	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
29	effect	effect	NOUN	NN	Number=Sing	_	_	_	_
30	on	on	ADP	IN	_	_	_	_	_
31	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
32	number	number	NOUN	NN	Number=Sing	_	_	_	_
33	of	of	ADP	IN	_	_	_	_	_
34	high	high	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
35	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
36	affinity	affinity	NOUN	NN	Number=Sing	_	_	_	_
37	IL	Il	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
38	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
39	2Rs	2R	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
40	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 356
# text = These results show that IL-2 is capable of inducing the nuclear expression of NF-kappaB in primary CD8+ T-PLL cells, and that this effect is mediated, at least in part, at a pretranslational level.
1	These	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
2	results	result	NOUN	NNS	Number=Plur	_	_	_	_
3	show	show	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
4	that	that	SCONJ	IN	_	_	_	_	_
5	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
6	-	-	SYM	SYM	_	_	_	_	SpaceAfter=No
7	2	2	NUM	CD	NumType=Card	_	_	_	_
8	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
9	capable	capable	ADJ	JJ	Degree=Pos	_	_	_	_
10	of	of	SCONJ	IN	_	_	_	_	_
11	inducing	induce	VERB	VBG	VerbForm=Ger	_	_	_	_
12	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
13	nuclear	nuclear	ADJ	JJ	Degree=Pos	_	_	_	_
14	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
15	of	of	ADP	IN	_	_	_	_	_
16	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
17	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
18	kappaB	kappaB	PROPN	NNP	Number=Sing	_	_	_	_
19	in	in	ADP	IN	_	_	_	_	_
20	primary	primary	ADJ	JJ	Degree=Pos	_	_	_	_
21	CD8	CD8	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
22	+	+	SYM	SYM	_	_	_	_	_
23	T	t	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
24	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
25	PLL	pLl	PROPN	NNP	Number=Sing	_	_	_	_
26	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
27	,	,	PUNCT	,	_	_	_	_	_
28	and	and	CCONJ	CC	_	_	_	_	_
29	that	that	SCONJ	IN	_	_	_	_	_
30	this	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
31	effect	effect	NOUN	NN	Number=Sing	_	_	_	_
32	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
33	mediated	mediate	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	SpaceAfter=No
34	,	,	PUNCT	,	_	_	_	_	_
35	at	at	ADV	RB	_	_	_	_	_
36	least	least	ADV	RBS	Degree=Sup	_	_	_	_
37	in	in	ADP	IN	_	_	_	_	_
38	part	part	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
39	,	,	PUNCT	,	_	_	_	_	_
40	at	at	ADP	IN	_	_	_	_	_
41	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
42	pretranslational	pretranslational	ADJ	JJ	Degree=Pos	_	_	_	_
43	level	level	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
44	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 357
# text = Document 003002129 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	003002129	003002129	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 358
# text = Impaired fetal thymocyte development after efficient adenovirus-mediated inhibition of NF-kappa B activation.
1	Impaired	Impaire	ADJ	JJ	Degree=Pos	_	_	_	_
2	fetal	fetal	ADJ	JJ	Degree=Pos	_	_	_	_
3	thymocyte	thymocyte	NOUN	NN	Number=Sing	_	_	_	_
4	development	development	NOUN	NN	Number=Sing	_	_	_	_
5	after	after	ADP	IN	_	_	_	_	_
6	efficient	efficient	ADJ	JJ	Degree=Pos	_	_	_	_
7	adenovirus	adenovirus	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
8	-mediated	-mediate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
9	inhibition	inhibition	NOUN	NN	Number=Sing	_	_	_	_
10	of	of	ADP	IN	_	_	_	_	_
11	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
12	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
13	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_
14	B	b	NOUN	NN	Number=Sing	_	_	_	_
15	activation	activation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
16	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 359
# text = We introduce a new experimental system combining adenovirus-mediated gene transfer and fetal thymic organ culture (FTOC).
1	We	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
2	introduce	introduce	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
3	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
4	new	new	ADJ	JJ	Degree=Pos	_	_	_	_
5	experimental	experimental	ADJ	JJ	Degree=Pos	_	_	_	_
6	system	system	NOUN	NN	Number=Sing	_	_	_	_
7	combining	combi	VERB	VBG	VerbForm=Ger	_	_	_	_
8	adenovirus	adenovirus	ADP	IN	_	_	_	_	SpaceAfter=No
9	-mediated	-mediate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
10	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
11	transfer	transfer	NOUN	NN	Number=Sing	_	_	_	_
12	and	and	CCONJ	CC	_	_	_	_	_
13	fetal	fetal	ADJ	JJ	Degree=Pos	_	_	_	_
14	thymic	thymic	ADJ	JJ	Degree=Pos	_	_	_	_
15	organ	organ	ADJ	JJ	Degree=Pos	_	_	_	_
16	culture	culture	NOUN	NN	Number=Sing	_	_	_	_
17	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
18	FTOC	FTOC	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
19	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
20	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 360
# text = This system allowed us to efficiently express in developing thymocytes a mutant form of the NF-kappa B inhibitor
1	This	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
2	system	system	NOUN	NN	Number=Sing	_	_	_	_
3	allowed	allow	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
4	us	we	PRON	PRP	Case=Acc|Number=Plur|Person=1|PronType=Prs	_	_	_	_
5	to	to	PART	TO	_	_	_	_	_
6	efficiently	efficiently	ADV	RB	_	_	_	_	_
7	express	express	VERB	VB	VerbForm=Inf	_	_	_	_
8	in	in	SCONJ	IN	_	_	_	_	_
9	developing	develop	VERB	VBG	VerbForm=Ger	_	_	_	_
10	thymocytes	thymocyte	NOUN	NNS	Number=Plur	_	_	_	_
11	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
12	mutant	mutant	ADJ	JJ	Degree=Pos	_	_	_	_
13	form	form	NOUN	NN	Number=Sing	_	_	_	_
14	of	of	ADP	IN	_	_	_	_	_
15	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
16	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
17	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
18	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_
19	B	b	NOUN	NN	Number=Sing	_	_	_	_
20	inhibitor	inhibitor	NOUN	NN	Number=Sing	_	_	_	_

# sent_id = 361
# text = I kappa B alpha (mut-I kappa B) and to study the maturation defects occurring when NF-kappa B activation is inhibited during fetal development.
1	I	I	PRON	PRP	Case=Nom|Number=Sing|Person=1|PronType=Prs	_	_	_	_
2	kappa	kappa	X	FW	Foreign=Yes	_	_	_	_
3	B	b	ADJ	JJ	Degree=Pos	_	_	_	_
4	alpha	alpha	NOUN	NN	Number=Sing	_	_	_	_
5	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
6	mut	mut	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
7	-	-	PUNCT	:	_	_	_	_	SpaceAfter=No
8	I	I	PRON	PRP	Case=Nom|Number=Sing|Person=1|PronType=Prs	_	_	_	_
9	kappa	kappa	PROPN	NNP	Number=Sing	_	_	_	_
10	B	b	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
11	)	)	PUNCT	-RRB-	_	_	_	_	_
12	and	and	CCONJ	CC	_	_	_	_	_
13	to	to	PART	TO	_	_	_	_	_
14	study	study	VERB	VB	VerbForm=Inf	_	_	_	_
15	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
16	maturation	maturation	NOUN	NN	Number=Sing	_	_	_	_
17	defects	defect	NOUN	NNS	Number=Plur	_	_	_	_
18	occurring	occurre	VERB	VBG	VerbForm=Ger	_	_	_	_
19	when	when	ADV	WRB	PronType=Int	_	_	_	_
20	NF	NF	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
21	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
22	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_
23	B	b	NOUN	NN	Number=Sing	_	_	_	_
24	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
25	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
26	inhibited	inhibit	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
27	during	during	ADP	IN	_	_	_	_	_
28	fetal	fetal	ADJ	JJ	Degree=Pos	_	_	_	_
29	development	development	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
30	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 362
# text = Fetal thymocytes infected with adenovirus containing mut-I kappa B were found to develop normally until the CD44-CD25+, CD4-CD8- double-negative stage, while production of more mature double-positive and single-positive populations was strongly decreased.
1	Fetal	Fetal	ADJ	JJ	Degree=Pos	_	_	_	_
2	thymocytes	thymocyte	NOUN	NNS	Number=Plur	_	_	_	_
3	infected	infect	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
4	with	with	ADP	IN	_	_	_	_	_
5	adenovirus	adenovirus	NOUN	NN	Number=Sing	_	_	_	_
6	containing	containing	VERB	VBG	VerbForm=Ger	_	_	_	_
7	mut	mut	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
8	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
9	I	I	PRON	PRP	Case=Nom|Number=Sing|Person=1|PronType=Prs	_	_	_	_
10	kappa	kappa	PROPN	NNP	Number=Sing	_	_	_	_
11	B	b	PROPN	NNP	Number=Sing	_	_	_	_
12	were	be	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
13	found	find	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
14	to	to	PART	TO	_	_	_	_	_
15	develop	develop	VERB	VB	VerbForm=Inf	_	_	_	_
16	normally	normally	ADV	RB	_	_	_	_	_
17	until	until	ADP	IN	_	_	_	_	_
18	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
19	CD44-CD25+	Cd44-cd25+	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
20	,	,	PUNCT	,	_	_	_	_	_
21	CD4-CD8	Cd4-cd8	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
22	-	-	PUNCT	HYPH	_	_	_	_	_
23	double	double	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
24	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
25	negative	negative	ADJ	JJ	Degree=Pos	_	_	_	_
26	stage	stage	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
27	,	,	PUNCT	,	_	_	_	_	_
28	while	while	SCONJ	IN	_	_	_	_	_
29	production	production	NOUN	NN	Number=Sing	_	_	_	_
30	of	of	ADP	IN	_	_	_	_	_
31	more	more	ADJ	JJR	Degree=Cmp	_	_	_	_
32	mature	mature	ADJ	JJ	Degree=Pos	_	_	_	_
33	double	double	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
34	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
35	positive	positive	ADJ	JJ	Degree=Pos	_	_	_	_
36	and	and	CCONJ	CC	_	_	_	_	_
37	single	single	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
38	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
39	positive	positive	ADJ	JJ	Degree=Pos	_	_	_	_
40	populations	population	NOUN	NNS	Number=Plur	_	_	_	_
41	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
42	strongly	strongly	ADV	RB	_	_	_	_	_
43	decreased	decrease	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	SpaceAfter=No
44	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 363
# text = Proliferation, as measured by the percentage of cells in cycle appeared normal, as did rearrangement and expression of the TCR beta-chain.
1	Proliferation	proliferation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
2	,	,	PUNCT	,	_	_	_	_	_
3	as	as	SCONJ	IN	_	_	_	_	_
4	measured	measure	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
5	by	by	ADP	IN	_	_	_	_	_
6	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
7	percentage	percentage	NOUN	NN	Number=Sing	_	_	_	_
8	of	of	ADP	IN	_	_	_	_	_
9	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
10	in	in	ADP	IN	_	_	_	_	_
11	cycle	cycle	NOUN	NN	Number=Sing	_	_	_	_
12	appeared	appear	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
13	normal	normal	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
14	,	,	PUNCT	,	_	_	_	_	_
15	as	as	SCONJ	IN	_	_	_	_	_
16	did	do	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
17	rearrangement	rearrangement	NOUN	NN	Number=Sing	_	_	_	_
18	and	and	CCONJ	CC	_	_	_	_	_
19	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
20	of	of	ADP	IN	_	_	_	_	_
21	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
22	TCR	TCR	PROPN	NNP	Number=Sing	_	_	_	_
23	beta	beta	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
24	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
25	chain	chain	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
26	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 364
# text = However, apoptosis was much higher in FTOC infected with adenovirus containing mut-I kappa B than in FTOC infected with a control virus.
1	However	however	ADV	RB	_	_	_	_	SpaceAfter=No
2	,	,	PUNCT	,	_	_	_	_	_
3	apoptosis	apoptosis	PRON	DT	Number=Sing|PronType=Dem	_	_	_	_
4	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
5	much	much	ADV	RB	_	_	_	_	_
6	higher	higher	ADJ	JJR	Degree=Cmp	_	_	_	_
7	in	in	ADP	IN	_	_	_	_	_
8	FTOC	FTOC	PROPN	NNP	Number=Sing	_	_	_	_
9	infected	infect	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
10	with	with	ADP	IN	_	_	_	_	_
11	adenovirus	adenovirus	NOUN	NN	Number=Sing	_	_	_	_
12	containing	containing	VERB	VBG	VerbForm=Ger	_	_	_	_
13	mut	mut	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
14	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
15	I	I	PRON	PRP	Case=Nom|Number=Sing|Person=1|PronType=Prs	_	_	_	_
16	kappa	kappa	PROPN	NNP	Number=Sing	_	_	_	_
17	B	b	PROPN	NNP	Number=Sing	_	_	_	_
18	than	than	ADP	IN	_	_	_	_	_
19	in	in	ADP	IN	_	_	_	_	_
20	FTOC	FTOC	PROPN	NNP	Number=Sing	_	_	_	_
21	infected	infect	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
22	with	with	ADP	IN	_	_	_	_	_
23	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
24	control	control	NOUN	NN	Number=Sing	_	_	_	_
25	virus	virus	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
26	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 365
# text = Taken together, these results suggest that NF-kappa B plays a crucial role in ensuring the differentiation and survival of thymocytes in the early stages of their development.
1	Taken	take	PROPN	NNP	Number=Sing	_	_	_	_
2	together	together	ADV	RB	_	_	_	_	SpaceAfter=No
3	,	,	PUNCT	,	_	_	_	_	_
4	these	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
5	results	result	NOUN	NNS	Number=Plur	_	_	_	_
6	suggest	suggest	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
7	that	that	SCONJ	IN	_	_	_	_	_
8	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
9	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
10	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_
11	B	b	NOUN	NN	Number=Sing	_	_	_	_
12	plays	play	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
13	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
14	crucial	crucial	ADJ	JJ	Degree=Pos	_	_	_	_
15	role	role	NOUN	NN	Number=Sing	_	_	_	_
16	in	in	SCONJ	IN	_	_	_	_	_
17	ensuring	ensure	VERB	VBG	VerbForm=Ger	_	_	_	_
18	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
19	differentiation	differentiation	NOUN	NN	Number=Sing	_	_	_	_
20	and	and	CCONJ	CC	_	_	_	_	_
21	survival	survival	NOUN	NN	Number=Sing	_	_	_	_
22	of	of	ADP	IN	_	_	_	_	_
23	thymocytes	thymocyte	NOUN	NNS	Number=Plur	_	_	_	_
24	in	in	ADP	IN	_	_	_	_	_
25	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
26	early	early	ADJ	JJ	Degree=Pos	_	_	_	_
27	stages	stage	NOUN	NNS	Number=Plur	_	_	_	_
28	of	of	ADP	IN	_	_	_	_	_
29	their	they	PRON	PRP$	Number=Plur|Person=3|Poss=Yes|PronType=Prs	_	_	_	_
30	development	development	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
31	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 366
# text = Document 003002140 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	003002140	003002140	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 367
# text = Positive and negative regulation of granulocyte-macrophage colony-stimulating factor promoter activity by AML1-related transcription factor, PEBP2.
1	Positive	positive	ADJ	JJ	Degree=Pos	_	_	_	_
2	and	and	CCONJ	CC	_	_	_	_	_
3	negative	negative	ADJ	JJ	Degree=Pos	_	_	_	_
4	regulation	regulation	NOUN	NN	Number=Sing	_	_	_	_
5	of	of	ADP	IN	_	_	_	_	_
6	granulocyte	granulocyte	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
7	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
8	macrophage	macrophage	NOUN	NN	Number=Sing	_	_	_	_
9	colony	colony	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
10	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
11	stimulating	stimulating	VERB	VBG	VerbForm=Ger	_	_	_	_
12	factor	factor	NOUN	NN	Number=Sing	_	_	_	_
13	promoter	promoter	NOUN	NN	Number=Sing	_	_	_	_
14	activity	activity	NOUN	NN	Number=Sing	_	_	_	_
15	by	by	ADP	IN	_	_	_	_	_
16	AML1	AML1	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
17	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
18	related	related	ADJ	JJ	Degree=Pos	_	_	_	_
19	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
20	factor	factor	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
21	,	,	PUNCT	,	_	_	_	_	_
22	PEBP2	Pebp2	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
23	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 368
# text = The granulocyte-macrophage colony-stimulating factor (GM-CSF) gene promoter contains a consensus sequence for the polyomavirus enhancer binding-protein 2 (PEBP2) transcription factor, which consists of alpha and beta subunits.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	granulocyte	granulocyte	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
3	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
4	macrophage	macrophage	NOUN	NN	Number=Sing	_	_	_	_
5	colony	colony	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
6	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
7	stimulating	stimulating	NOUN	NN	Number=Sing	_	_	_	_
8	factor	factor	NOUN	NN	Number=Sing	_	_	_	_
9	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
10	GM	GM	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
11	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
12	CSF	CSF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
13	)	)	PUNCT	-RRB-	_	_	_	_	_
14	gene	gene	ADJ	JJ	Degree=Pos	_	_	_	_
15	promoter	promoter	NOUN	NN	Number=Sing	_	_	_	_
16	contains	contain	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
17	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
18	consensus	consensus	NOUN	NN	Number=Sing	_	_	_	_
19	sequence	sequence	NOUN	NN	Number=Sing	_	_	_	_
20	for	for	ADP	IN	_	_	_	_	_
21	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
22	polyomavirus	polyomavirus	NOUN	NN	Number=Sing	_	_	_	_
23	enhancer	enhancer	NOUN	NN	Number=Sing	_	_	_	_
24	binding	binding	VERB	VBG	VerbForm=Ger	_	_	_	SpaceAfter=No
25	-	-	PUNCT	:	_	_	_	_	SpaceAfter=No
26	protein	protein	NOUN	NN	Number=Sing	_	_	_	_
27	2	2	NUM	CD	NumType=Card	_	_	_	_
28	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
29	PEBP2	PEBP2	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
30	)	)	PUNCT	-RRB-	_	_	_	_	_
31	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
32	factor	factor	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
33	,	,	PUNCT	,	_	_	_	_	_
34	which	which	PRON	WDT	PronType=Rel	_	_	_	_
35	consists	consist	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
36	of	of	ADP	IN	_	_	_	_	_
37	alpha	alpha	NOUN	NN	Number=Sing	_	_	_	_
38	and	and	CCONJ	CC	_	_	_	_	_
39	beta	beta	NOUN	NN	Number=Sing	_	_	_	_
40	subunits	subunit	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
41	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 369
# text = There are at least two genes, alpha
1	There	there	PRON	EX	_	_	_	_	_
2	are	be	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
3	at	at	ADV	RB	_	_	_	_	_
4	least	least	ADV	RBS	Degree=Sup	_	_	_	_
5	two	two	NUM	CD	NumType=Card	_	_	_	_
6	genes	gene	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
7	,	,	PUNCT	,	_	_	_	_	_
8	alpha	alpha	NOUN	NN	Number=Sing	_	_	_	_

# sent_id = 370
# text = A and alpha B, encoding the alpha subunit.
1	A	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
2	and	and	CCONJ	CC	_	_	_	_	_
3	alpha	alpha	NOUN	NN	Number=Sing	_	_	_	_
4	B	b	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
5	,	,	PUNCT	,	_	_	_	_	_
6	encoding	encod	VERB	VBG	VerbForm=Ger	_	_	_	_
7	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
8	alpha	alpha	NOUN	NN	Number=Sing	_	_	_	_
9	subunit	subunit	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
10	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 371
# text = alpha
1	alpha	alpha	NOUN	NN	Number=Sing	_	_	_	_

# sent_id = 372
# text = B is the mouse homologue of human AML1 gene detected at the breakpoints of t(8;21) and t(3;21) myeloid leukemias.
1	B	b	NOUN	NN	Number=Sing	_	_	_	_
2	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
3	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
4	mouse	mouse	NOUN	NN	Number=Sing	_	_	_	_
5	homologue	homologue	NOUN	NN	Number=Sing	_	_	_	_
6	of	of	ADP	IN	_	_	_	_	_
7	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
8	AML1	AML1	NOUN	NN	Number=Sing	_	_	_	_
9	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
10	detected	detect	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
11	at	at	ADP	IN	_	_	_	_	_
12	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
13	breakpoints	breakpoint	NOUN	NNS	Number=Plur	_	_	_	_
14	of	of	ADP	IN	_	_	_	_	_
15	t	t	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
16	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
17	8;21	8;21	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
18	)	)	PUNCT	-RRB-	_	_	_	_	_
19	and	and	CCONJ	CC	_	_	_	_	_
20	t	t	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
21	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
22	3;21	3;21	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
23	)	)	PUNCT	-RRB-	_	_	_	_	_
24	myeloid	myeloid	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
25	leukemias	leukemia	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
26	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 373
# text = We examined alpha A1 (an alpha
1	We	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
2	examined	examin	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
3	alpha	alpha	ADP	IN	_	_	_	_	_
4	A1	A1	PROPN	NNP	Number=Sing	_	_	_	_
5	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
6	an	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
7	alpha	alpha	NOUN	NN	Number=Sing	_	_	_	_

# sent_id = 374
# text = A-gene product) and alpha B1 and alpha B2 (two alpha B-encoded isomers) for their effects on the GM-CSF promoter.
1	A	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	SpaceAfter=No
2	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
3	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
4	product	product	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
5	)	)	PUNCT	-RRB-	_	_	_	_	_
6	and	and	CCONJ	CC	_	_	_	_	_
7	alpha	alpha	PROPN	NNP	Number=Sing	_	_	_	_
8	B1	B1	PROPN	NNP	Number=Sing	_	_	_	_
9	and	and	CCONJ	CC	_	_	_	_	_
10	alpha	alpha	ADP	IN	_	_	_	_	_
11	B2	b2	NOUN	NN	Number=Sing	_	_	_	_
12	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
13	two	two	NUM	CD	NumType=Card	_	_	_	_
14	alpha	alpha	NOUN	NN	Number=Sing	_	_	_	_
15	B	b	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
16	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
17	encoded	encod	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
18	isomers	isomer	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
19	)	)	PUNCT	-RRB-	_	_	_	_	_
20	for	for	ADP	IN	_	_	_	_	_
21	their	they	PRON	PRP$	Number=Plur|Person=3|Poss=Yes|PronType=Prs	_	_	_	_
22	effects	effect	NOUN	NNS	Number=Plur	_	_	_	_
23	on	on	ADP	IN	_	_	_	_	_
24	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
25	GM	GM	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
26	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
27	CSF	CSF	PROPN	NNP	Number=Sing	_	_	_	_
28	promoter	promoter	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
29	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 375
# text = PEBP2 alpha A1, alpha B1, and alpha B2 proteins bound the PEBP2 site within the mouse GM-CSF promoter.
1	PEBP2	PEBP2	NOUN	NN	Number=Sing	_	_	_	_
2	alpha	alpha	ADP	IN	_	_	_	_	_
3	A1	A1	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
4	,	,	PUNCT	,	_	_	_	_	_
5	alpha	alpha	ADP	IN	_	_	_	_	_
6	B1	B1	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
7	,	,	PUNCT	,	_	_	_	_	_
8	and	and	CCONJ	CC	_	_	_	_	_
9	alpha	alpha	ADP	IN	_	_	_	_	_
10	B2	B2	NOUN	NN	Number=Sing	_	_	_	_
11	proteins	protein	NOUN	NNS	Number=Plur	_	_	_	_
12	bound	bound	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
13	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
14	PEBP2	Pebp2	NUM	CD	NumType=Card	_	_	_	_
15	site	site	NOUN	NN	Number=Sing	_	_	_	_
16	within	within	ADP	IN	_	_	_	_	_
17	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
18	mouse	mouse	NOUN	NN	Number=Sing	_	_	_	_
19	GM	GM	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
20	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
21	CSF	CSF	PROPN	NNP	Number=Sing	_	_	_	_
22	promoter	promoter	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
23	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 376
# text = PEBP2 alpha A1 and alpha B1 enhanced the expression of the GM-CSF promoter-driven reporter plasmid in unstimulated and 12-O-tetradecanoylphorbol 13-acetate/phytohemagglutinin-stimulated human Jurkat T cells.
1	PEBP2	PEBP2	NOUN	NN	Number=Sing	_	_	_	_
2	alpha	alpha	ADP	IN	_	_	_	_	_
3	A1	A1	PROPN	NNP	Number=Sing	_	_	_	_
4	and	and	CCONJ	CC	_	_	_	_	_
5	alpha	alpha	PROPN	NNP	Number=Sing	_	_	_	_
6	B1	B1	PROPN	NNP	Number=Sing	_	_	_	_
7	enhanced	enhance	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
8	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
9	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
10	of	of	ADP	IN	_	_	_	_	_
11	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
12	GM	GM	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
13	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
14	CSF	CSF	PROPN	NNP	Number=Sing	_	_	_	_
15	promoter	promoter	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
16	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
17	driven	drive	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
18	reporter	reporter	NOUN	NN	Number=Sing	_	_	_	_
19	plasmid	plasmid	NOUN	NN	Number=Sing	_	_	_	_
20	in	in	ADP	IN	_	_	_	_	_
21	unstimulated	unstimulated	ADJ	JJ	Degree=Pos	_	_	_	_
22	and	and	CCONJ	CC	_	_	_	_	_
23	12	12	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
24	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
25	O	of	ADP	IN	Abbr=Yes	_	_	_	SpaceAfter=No
26	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
27	tetradecanoylphorbol	tetradecanoylphorbol	NOUN	NN	Number=Sing	_	_	_	_
28	13-acetate/phytohemagglutinin-stimulated	13-acetate/phytohemagglutinin-stimulated	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
29	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
30	Jurkat	Jurkat	PROPN	NNP	Number=Sing	_	_	_	_
31	T	T	PROPN	NNP	Number=Sing	_	_	_	_
32	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
33	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 377
# text = In contrast, the promoter activity was suppressed by alpha B2. Coexpression of alpha B1 and alpha B2 showed that the promoter activity could be determined by the alpha B1/alpha B2 ratio.
1	In	in	ADP	IN	_	_	_	_	_
2	contrast	contrast	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
3	,	,	PUNCT	,	_	_	_	_	_
4	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
5	promoter	promoter	ADJ	JJ	Degree=Pos	_	_	_	_
6	activity	activity	NOUN	NN	Number=Sing	_	_	_	_
7	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
8	suppressed	suppress	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
9	by	by	ADP	IN	_	_	_	_	_
10	alpha	alpha	NOUN	NN	Number=Sing	_	_	_	_
11	B2	B2	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
12	.	.	PUNCT	.	_	_	_	_	_
13	Coexpression	Coexpression	NOUN	NN	Number=Sing	_	_	_	_
14	of	of	ADP	IN	_	_	_	_	_
15	alpha	alpha	NOUN	NN	Number=Sing	_	_	_	_
16	B1	b1	NOUN	NN	Number=Sing	_	_	_	_
17	and	and	CCONJ	CC	_	_	_	_	_
18	alpha	alpha	NOUN	NN	Number=Sing	_	_	_	_
19	B2	B2	NOUN	NN	Number=Sing	_	_	_	_
20	showed	show	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
21	that	that	SCONJ	IN	_	_	_	_	_
22	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
23	promoter	promoter	NOUN	NN	Number=Sing	_	_	_	_
24	activity	activity	NOUN	NN	Number=Sing	_	_	_	_
25	could	could	AUX	MD	VerbForm=Fin	_	_	_	_
26	be	be	AUX	VB	VerbForm=Inf	_	_	_	_
27	determined	determine	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
28	by	by	ADP	IN	_	_	_	_	_
29	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
30	alpha	alpha	NOUN	NN	Number=Sing	_	_	_	_
31	B1	B1	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
32	/	/	PUNCT	,	_	_	_	_	SpaceAfter=No
33	alpha	alpha	NOUN	NN	Number=Sing	_	_	_	_
34	B2	B2	NUM	CD	NumType=Card	_	_	_	_
35	ratio	ratio	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
36	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 378
# text = Jurkat cell extract contained PEBP2 site-binding protein(s) that cross-reacted with antimouse alpha A1 antibodies.
1	Jurkat	Jurkat	PROPN	NNP	Number=Sing	_	_	_	_
2	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
3	extract	extract	NOUN	NN	Number=Sing	_	_	_	_
4	contained	contain	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
5	PEBP2	PEBP2	NUM	CD	NumType=Card	_	_	_	_
6	site	site	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
7	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
8	binding	binding	VERB	VBG	VerbForm=Ger	_	_	_	_
9	protein	protein	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
10	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
11	s	s	X	AFX	_	_	_	_	SpaceAfter=No
12	)	)	PUNCT	-RRB-	_	_	_	_	_
13	that	that	PRON	WDT	PronType=Rel	_	_	_	_
14	cross-reacted	cross-reacted	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
15	with	with	ADP	IN	_	_	_	_	_
16	antimouse	antimouse	NOUN	NN	Number=Sing	_	_	_	_
17	alpha	alpha	NOUN	NN	Number=Sing	_	_	_	_
18	A1	A1	NUM	CD	NumType=Card	_	_	_	_
19	antibodies	antibody	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
20	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 379
# text = Northern blot analysis indicated the expression of human PEBP2 alpha
1	Northern	Northern	ADJ	JJ	Degree=Pos	_	_	_	_
2	blot	blot	NOUN	NN	Number=Sing	_	_	_	_
3	analysis	analysis	NOUN	NN	Number=Sing	_	_	_	_
4	indicated	indicate	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
5	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
6	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
7	of	of	ADP	IN	_	_	_	_	_
8	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
9	PEBP2	Pebp2	NOUN	NN	Number=Sing	_	_	_	_
10	alpha	alpha	NOUN	NN	Number=Sing	_	_	_	_

# sent_id = 380
# text = A, alpha B (AML1), and beta genes in Jurkat cells.
1	A	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	SpaceAfter=No
2	,	,	PUNCT	,	_	_	_	_	_
3	alpha	alpha	NOUN	NN	Number=Sing	_	_	_	_
4	B	b	NOUN	NN	Number=Sing	_	_	_	_
5	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
6	AML1	Aml1	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
7	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
8	,	,	PUNCT	,	_	_	_	_	_
9	and	and	CCONJ	CC	_	_	_	_	_
10	beta	beta	NOUN	NN	Number=Sing	_	_	_	_
11	genes	gene	NOUN	NNS	Number=Plur	_	_	_	_
12	in	in	ADP	IN	_	_	_	_	_
13	Jurkat	Jurkat	PROPN	NNP	Number=Sing	_	_	_	_
14	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
15	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 381
# text = Although further studies are required to determine the precise role of PEBP2 in the GM-CSF promoter activity, the present findings suggested the importance of the relative ratio of different PEBP2 isoforms in regulating the levels of the promoter activity.
1	Although	although	SCONJ	IN	_	_	_	_	_
2	further	further	ADJ	JJ	Degree=Pos	_	_	_	_
3	studies	study	NOUN	NNS	Number=Plur	_	_	_	_
4	are	be	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
5	required	require	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
6	to	to	PART	TO	_	_	_	_	_
7	determine	determine	VERB	VB	VerbForm=Inf	_	_	_	_
8	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
9	precise	precise	ADJ	JJ	Degree=Pos	_	_	_	_
10	role	role	NOUN	NN	Number=Sing	_	_	_	_
11	of	of	ADP	IN	_	_	_	_	_
12	PEBP2	Pebp2	NUM	CD	NumType=Card	_	_	_	_
13	in	in	ADP	IN	_	_	_	_	_
14	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
15	GM	GM	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
16	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
17	CSF	CSF	PROPN	NNP	Number=Sing	_	_	_	_
18	promoter	promoter	NOUN	NN	Number=Sing	_	_	_	_
19	activity	activity	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
20	,	,	PUNCT	,	_	_	_	_	_
21	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
22	present	present	ADJ	JJ	Degree=Pos	_	_	_	_
23	findings	finding	NOUN	NNS	Number=Plur	_	_	_	_
24	suggested	suggest	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
25	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
26	importance	importance	NOUN	NN	Number=Sing	_	_	_	_
27	of	of	ADP	IN	_	_	_	_	_
28	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
29	relative	relative	ADJ	JJ	Degree=Pos	_	_	_	_
30	ratio	ratio	NOUN	NN	Number=Sing	_	_	_	_
31	of	of	ADP	IN	_	_	_	_	_
32	different	different	ADJ	JJ	Degree=Pos	_	_	_	_
33	PEBP2	PEBP2	NUM	CD	NumType=Card	_	_	_	_
34	isoforms	isoform	NOUN	NNS	Number=Plur	_	_	_	_
35	in	in	SCONJ	IN	_	_	_	_	_
36	regulating	regulate	VERB	VBG	VerbForm=Ger	_	_	_	_
37	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
38	levels	level	NOUN	NNS	Number=Plur	_	_	_	_
39	of	of	ADP	IN	_	_	_	_	_
40	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
41	promoter	promoter	ADJ	JJ	Degree=Pos	_	_	_	_
42	activity	activity	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
43	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 382
# text = Document 003002141 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	003002141	003002141	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 383
# text = Transcriptional regulation of lysosomal acid lipase in differentiating monocytes is mediated by transcription factors Sp1 and AP-2.
1	Transcriptional	Transcriptional	ADJ	JJ	Degree=Pos	_	_	_	_
2	regulation	regulation	NOUN	NN	Number=Sing	_	_	_	_
3	of	of	ADP	IN	_	_	_	_	_
4	lysosomal	lysosomal	ADJ	JJ	Degree=Pos	_	_	_	_
5	acid	acid	ADJ	JJ	Degree=Pos	_	_	_	_
6	lipase	lipase	NOUN	NN	Number=Sing	_	_	_	_
7	in	in	ADP	IN	_	_	_	_	_
8	differentiating	differentiating	NOUN	NN	Number=Sing	_	_	_	_
9	monocytes	monocyte	NOUN	NNS	Number=Plur	_	_	_	_
10	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
11	mediated	mediate	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
12	by	by	ADP	IN	_	_	_	_	_
13	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
14	factors	factor	NOUN	NNS	Number=Plur	_	_	_	_
15	Sp1	Sp1	NUM	CD	NumType=Card	_	_	_	_
16	and	and	CCONJ	CC	_	_	_	_	_
17	AP	ap	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
18	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
19	2	2	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
20	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 384
# text = Human lysosomal acid lipase (LAL) is a hydrolase required for the cleavage of cholesteryl esters and triglycerides derived from plasma lipoproteins.
1	Human	human	ADJ	JJ	Degree=Pos	_	_	_	_
2	lysosomal	lysosomal	ADJ	JJ	Degree=Pos	_	_	_	_
3	acid	acid	NOUN	NN	Number=Sing	_	_	_	_
4	lipase	lipase	NOUN	NN	Number=Sing	_	_	_	_
5	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
6	LAL	LAL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
7	)	)	PUNCT	-RRB-	_	_	_	_	_
8	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
9	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
10	hydrolase	hydrolase	NOUN	NN	Number=Sing	_	_	_	_
11	required	require	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
12	for	for	ADP	IN	_	_	_	_	_
13	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
14	cleavage	cleavage	NOUN	NN	Number=Sing	_	_	_	_
15	of	of	ADP	IN	_	_	_	_	_
16	cholesteryl	cholesteryl	ADJ	JJ	Degree=Pos	_	_	_	_
17	esters	ester	NOUN	NNS	Number=Plur	_	_	_	_
18	and	and	CCONJ	CC	_	_	_	_	_
19	triglycerides	triglyceride	NOUN	NNS	Number=Plur	_	_	_	_
20	derived	derive	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
21	from	from	ADP	IN	_	_	_	_	_
22	plasma	plasma	NOUN	NN	Number=Sing	_	_	_	_
23	lipoproteins	lipoprotein	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
24	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 385
# text = It is shown here that during monocyte to macrophage differentiation, the expression of LAL-mRNA is induced.
1	It	it	PRON	PRP	Case=Nom|Gender=Neut|Number=Sing|Person=3|PronType=Prs	_	_	_	_
2	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
3	shown	show	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
4	here	here	ADV	RB	PronType=Dem	_	_	_	_
5	that	that	SCONJ	IN	_	_	_	_	_
6	during	during	ADP	IN	_	_	_	_	_
7	monocyte	monocyte	NOUN	NN	Number=Sing	_	_	_	_
8	to	to	ADP	IN	_	_	_	_	_
9	macrophage	macrophage	NOUN	NN	Number=Sing	_	_	_	_
10	differentiation	differentiation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
11	,	,	PUNCT	,	_	_	_	_	_
12	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
13	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
14	of	of	ADP	IN	_	_	_	_	_
15	LAL	LAL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
16	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
17	mRNA	mRNA	PROPN	NNP	Number=Sing	_	_	_	_
18	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
19	induced	induce	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	SpaceAfter=No
20	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 386
# text = This induction is dependent on protein kinase C activity and protein synthesis.
1	This	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
2	induction	induction	NOUN	NN	Number=Sing	_	_	_	_
3	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
4	dependent	dependent	ADJ	JJ	Degree=Pos	_	_	_	_
5	on	on	ADP	IN	_	_	_	_	_
6	protein	protein	NOUN	NN	Number=Sing	_	_	_	_
7	kinase	kinase	NOUN	NN	Number=Sing	_	_	_	_
8	C	C	NOUN	NN	Number=Sing	_	_	_	_
9	activity	activity	NOUN	NN	Number=Sing	_	_	_	_
10	and	and	CCONJ	CC	_	_	_	_	_
11	protein	protein	NOUN	NN	Number=Sing	_	_	_	_
12	synthesis	synthesis	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
13	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 387
# text = The cell type-specific increase in LAL expression is further investigated in the THP-1 cell line with respect to transcriptional regulation.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
3	type	type	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
4	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
5	specific	specific	ADJ	JJ	Degree=Pos	_	_	_	_
6	increase	increase	NOUN	NN	Number=Sing	_	_	_	_
7	in	in	ADP	IN	_	_	_	_	_
8	LAL	Lal	ADJ	JJ	Degree=Pos	_	_	_	_
9	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
10	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
11	further	further	ADV	RB	_	_	_	_	_
12	investigated	investigate	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
13	in	in	ADP	IN	_	_	_	_	_
14	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
15	THP	Thp	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
16	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
17	1	1	NUM	CD	NumType=Card	_	_	_	_
18	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
19	line	line	NOUN	NN	Number=Sing	_	_	_	_
20	with	with	ADP	IN	_	_	_	_	_
21	respect	respect	NOUN	NN	Number=Sing	_	_	_	_
22	to	to	ADP	IN	_	_	_	_	_
23	transcriptional	transcriptional	ADJ	JJ	Degree=Pos	_	_	_	_
24	regulation	regulation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
25	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 388
# text = The human monocytic leukemia cell line THP-1 differentiates into macrophage-like cells when treated with phorbol esters.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
3	monocytic	monocytic	ADJ	JJ	Degree=Pos	_	_	_	_
4	leukemia	leukemia	NOUN	NN	Number=Sing	_	_	_	_
5	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
6	line	line	NOUN	NN	Number=Sing	_	_	_	_
7	THP	Thp	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
8	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
9	1	1	NUM	CD	NumType=Card	_	_	_	_
10	differentiates	differentiate	NOUN	NNS	Number=Plur	_	_	_	_
11	into	into	ADP	IN	_	_	_	_	_
12	macrophage	macrophage	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
13	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
14	like	like	ADJ	JJ	Degree=Pos	_	_	_	_
15	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
16	when	when	ADV	WRB	PronType=Int	_	_	_	_
17	treated	treat	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
18	with	with	ADP	IN	_	_	_	_	_
19	phorbol	phorbol	NOUN	NN	Number=Sing	_	_	_	_
20	esters	ester	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
21	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 389
# text = In order to determine the cis-acting elements necessary for both basal and phorbol 12-myristate-13 acetate (PMA)-enhanced promoter activity, we performed deletion analysis and reporter gene assays.
1	In	in	ADP	IN	_	_	_	_	_
2	order	order	NOUN	NN	Number=Sing	_	_	_	_
3	to	to	PART	TO	_	_	_	_	_
4	determine	determine	VERB	VB	VerbForm=Inf	_	_	_	_
5	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
6	cis	cis	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
7	-acting	-act	VERB	VBG	VerbForm=Ger	_	_	_	_
8	elements	element	NOUN	NNS	Number=Plur	_	_	_	_
9	necessary	necessary	ADJ	JJ	Degree=Pos	_	_	_	_
10	for	for	ADP	IN	_	_	_	_	_
11	both	both	CCONJ	CC	_	_	_	_	_
12	basal	basal	ADJ	JJ	Degree=Pos	_	_	_	_
13	and	and	CCONJ	CC	_	_	_	_	_
14	phorbol	phorbol	ADJ	JJ	Degree=Pos	_	_	_	_
15	12	12	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
16	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
17	myristate	myristate	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
18	-13	-13	NUM	CD	NumType=Card	_	_	_	_
19	acetate	acetate	NOUN	NN	Number=Sing	_	_	_	_
20	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
21	PMA	PMA	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
22	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
23	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
24	enhanced	enhance	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
25	promoter	promoter	NOUN	NN	Number=Sing	_	_	_	_
26	activity	activity	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
27	,	,	PUNCT	,	_	_	_	_	_
28	we	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
29	performed	perform	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
30	deletion	deletion	NOUN	NN	Number=Sing	_	_	_	_
31	analysis	analysis	NOUN	NN	Number=Sing	_	_	_	_
32	and	and	CCONJ	CC	_	_	_	_	_
33	reporter	reporter	NOUN	NN	Number=Sing	_	_	_	_
34	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
35	assays	assay	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
36	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 390
# text = A PMA responsive element has been identified between -182 bp and -107 bp upstream of the major transcription start site.
1	A	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
2	PMA	PMA	PROPN	NNP	Number=Sing	_	_	_	_
3	responsive	responsive	ADJ	JJ	Degree=Pos	_	_	_	_
4	element	element	NOUN	NN	Number=Sing	_	_	_	_
5	has	have	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
6	been	be	AUX	VBN	Tense=Past|VerbForm=Part	_	_	_	_
7	identified	identify	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
8	between	between	ADP	IN	_	_	_	_	_
9	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
10	182	182	NUM	CD	NumType=Card	_	_	_	_
11	bp	bp	NOUN	NN	Number=Sing	_	_	_	_
12	and	and	CCONJ	CC	_	_	_	_	_
13	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
14	107	107	NUM	CD	NumType=Card	_	_	_	_
15	bp	bp	NOUN	NN	Number=Sing	_	_	_	_
16	upstream	upstream	NOUN	NN	Number=Sing	_	_	_	_
17	of	of	ADP	IN	_	_	_	_	_
18	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
19	major	major	ADJ	JJ	Degree=Pos	_	_	_	_
20	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
21	start	start	NOUN	NN	Number=Sing	_	_	_	_
22	site	site	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
23	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 391
# text = Gel mobility shift assays demonstrated that binding of Sp1 and AP-2 to the LAL promoter is increased by PMA in THP-1 cells.
1	Gel	gel	NOUN	NN	Number=Sing	_	_	_	_
2	mobility	mobility	NOUN	NN	Number=Sing	_	_	_	_
3	shift	shift	NOUN	NN	Number=Sing	_	_	_	_
4	assays	assays	NOUN	NNS	Number=Plur	_	_	_	_
5	demonstrated	demonstrate	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
6	that	that	SCONJ	IN	_	_	_	_	_
7	binding	bind	VERB	VBG	VerbForm=Ger	_	_	_	_
8	of	of	ADP	IN	_	_	_	_	_
9	Sp1	sp1	NOUN	NN	Number=Sing	_	_	_	_
10	and	and	CCONJ	CC	_	_	_	_	_
11	AP	ap	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
12	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
13	2	2	NUM	CD	NumType=Card	_	_	_	_
14	to	to	ADP	IN	_	_	_	_	_
15	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
16	LAL	Lal	ADJ	JJ	Degree=Pos	_	_	_	_
17	promoter	promoter	NOUN	NN	Number=Sing	_	_	_	_
18	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
19	increased	increase	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
20	by	by	ADP	IN	_	_	_	_	_
21	PMA	PMA	PROPN	NNP	Number=Sing	_	_	_	_
22	in	in	ADP	IN	_	_	_	_	_
23	THP	THP	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
24	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
25	1	1	NUM	CD	NumType=Card	_	_	_	_
26	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
27	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 392
# text = Co-transfections with expression plasmids for Sp1 and AP-2 further emphasized the important role of these transcription factors in both basal and PMA-enhanced LAL expression.
1	Co	co	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
2	-transfections	-transfection	NOUN	NNS	Number=Plur	_	_	_	_
3	with	with	ADP	IN	_	_	_	_	_
4	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
5	plasmids	plasmid	NOUN	NNS	Number=Plur	_	_	_	_
6	for	for	ADP	IN	_	_	_	_	_
7	Sp1	sp1	NOUN	NN	Number=Sing	_	_	_	_
8	and	and	CCONJ	CC	_	_	_	_	_
9	AP	ap	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
10	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
11	2	2	NUM	CD	NumType=Card	_	_	_	_
12	further	further	ADV	RB	_	_	_	_	_
13	emphasized	emphasize	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
14	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
15	important	important	ADJ	JJ	Degree=Pos	_	_	_	_
16	role	role	NOUN	NN	Number=Sing	_	_	_	_
17	of	of	ADP	IN	_	_	_	_	_
18	these	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
19	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
20	factors	factor	NOUN	NNS	Number=Plur	_	_	_	_
21	in	in	ADP	IN	_	_	_	_	_
22	both	both	CCONJ	CC	_	_	_	_	_
23	basal	basal	ADJ	JJ	Degree=Pos	_	_	_	_
24	and	and	CCONJ	CC	_	_	_	_	_
25	PMA	Pma	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
26	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
27	enhanced	enhance	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
28	LAL	Lal	ADJ	JJ	Degree=Pos	_	_	_	_
29	expression	expression	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
30	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 393
# text = Our data suggest that differentiation dependent increase of lysosomal acid lipase (LAL) expression in THP-1 cells is mediated by a concerted action of Sp1 and AP-2.
1	Our	we	PRON	PRP$	Number=Plur|Person=1|Poss=Yes|PronType=Prs	_	_	_	_
2	data	data	NOUN	NN	Number=Sing	_	_	_	_
3	suggest	suggest	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
4	that	that	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
5	differentiation	differentiation	NOUN	NN	Number=Sing	_	_	_	_
6	dependent	dependent	ADJ	JJ	Degree=Pos	_	_	_	_
7	increase	increase	NOUN	NN	Number=Sing	_	_	_	_
8	of	of	ADP	IN	_	_	_	_	_
9	lysosomal	lysosomal	ADJ	JJ	Degree=Pos	_	_	_	_
10	acid	acid	ADJ	JJ	Degree=Pos	_	_	_	_
11	lipase	lipase	NOUN	NN	Number=Sing	_	_	_	_
12	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
13	LAL	LAL	INTJ	UH	_	_	_	_	SpaceAfter=No
14	)	)	PUNCT	-RRB-	_	_	_	_	_
15	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
16	in	in	ADP	IN	_	_	_	_	_
17	THP	THP	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
18	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
19	1	1	NUM	CD	NumType=Card	_	_	_	_
20	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
21	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
22	mediated	mediate	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
23	by	by	ADP	IN	_	_	_	_	_
24	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
25	concerted	concert	ADJ	JJ	Degree=Pos	_	_	_	_
26	action	action	NOUN	NN	Number=Sing	_	_	_	_
27	of	of	ADP	IN	_	_	_	_	_
28	Sp1	sp1	NUM	CD	NumType=Card	_	_	_	_
29	and	and	CCONJ	CC	_	_	_	_	_
30	AP	ap	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
31	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
32	2	2	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
33	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 394
# text = Document 003002142 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	003002142	003002142	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 395
# text = NF-kappaB regulates Fas/APO-1/CD95- and TCR- mediated apoptosis of T lymphocytes.
1	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
2	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
3	kappaB	kappaB	PROPN	NNP	Number=Sing	_	_	_	_
4	regulates	regulate	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
5	Fas/APO-1/CD95-	Fas/APO-1/CD95-	NOUN	NN	Number=Sing	_	_	_	_
6	and	and	CCONJ	CC	_	_	_	_	_
7	TCR	Tcr	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
8	-	-	PUNCT	HYPH	_	_	_	_	_
9	mediated	mediate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
10	apoptosis	apoptosis	NOUN	NN	Number=Sing	_	_	_	_
11	of	of	ADP	IN	_	_	_	_	_
12	T	t	PROPN	NNP	Number=Sing	_	_	_	_
13	lymphocytes	lymphocyte	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
14	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 396
# text = The maintenance of lymphocyte homeostasis by apoptosis is a critical regulatory mechanism in the normal immune system.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	maintenance	maintenance	NOUN	NN	Number=Sing	_	_	_	_
3	of	of	ADP	IN	_	_	_	_	_
4	lymphocyte	lymphocyte	NOUN	NN	Number=Sing	_	_	_	_
5	homeostasis	homeostasis	NOUN	NN	Number=Sing	_	_	_	_
6	by	by	ADP	IN	_	_	_	_	_
7	apoptosis	apoptosis	PRON	DT	Number=Sing|PronType=Dem	_	_	_	_
8	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
9	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
10	critical	critical	ADJ	JJ	Degree=Pos	_	_	_	_
11	regulatory	regulatory	ADJ	JJ	Degree=Pos	_	_	_	_
12	mechanism	mechanism	NOUN	NN	Number=Sing	_	_	_	_
13	in	in	ADP	IN	_	_	_	_	_
14	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
15	normal	normal	ADJ	JJ	Degree=Pos	_	_	_	_
16	immune	immune	ADJ	JJ	Degree=Pos	_	_	_	_
17	system	system	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
18	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 397
# text = The transcription factor NF-kappaB has been shown to play a role in protecting cells against death mediated by TNF
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
3	factor	factor	NOUN	NN	Number=Sing	_	_	_	_
4	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
5	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
6	kappaB	kappaB	PROPN	NNP	Number=Sing	_	_	_	_
7	has	have	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
8	been	be	AUX	VBN	Tense=Past|VerbForm=Part	_	_	_	_
9	shown	show	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
10	to	to	PART	TO	_	_	_	_	_
11	play	play	VERB	VB	VerbForm=Inf	_	_	_	_
12	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
13	role	role	NOUN	NN	Number=Sing	_	_	_	_
14	in	in	SCONJ	IN	_	_	_	_	_
15	protecting	protect	VERB	VBG	VerbForm=Ger	_	_	_	_
16	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
17	against	against	ADP	IN	_	_	_	_	_
18	death	death	NOUN	NN	Number=Sing	_	_	_	_
19	mediated	mediate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
20	by	by	ADP	IN	_	_	_	_	_
21	TNF	TNF	PROPN	NNP	Number=Sing	_	_	_	_

# sent_id = 398
# text = We show here that NF-kappaB also has a role in regulating Fas/APO-1/CD95-mediated death, a major pathway of peripheral T cell death.
1	We	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
2	show	show	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
3	here	here	ADV	RB	PronType=Dem	_	_	_	_
4	that	that	SCONJ	IN	_	_	_	_	_
5	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
6	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
7	kappaB	kappaB	PROPN	NNP	Number=Sing	_	_	_	_
8	also	also	ADV	RB	_	_	_	_	_
9	has	have	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
10	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
11	role	role	NOUN	NN	Number=Sing	_	_	_	_
12	in	in	SCONJ	IN	_	_	_	_	_
13	regulating	regulate	VERB	VBG	VerbForm=Ger	_	_	_	_
14	Fas/APO-1/CD95-mediated	Fas/APO-1/CD95-mediated	ADJ	JJ	Degree=Pos	_	_	_	_
15	death	death	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
16	,	,	PUNCT	,	_	_	_	_	_
17	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
18	major	major	ADJ	JJ	Degree=Pos	_	_	_	_
19	pathway	pathway	NOUN	NN	Number=Sing	_	_	_	_
20	of	of	ADP	IN	_	_	_	_	_
21	peripheral	peripheral	ADJ	JJ	Degree=Pos	_	_	_	_
22	T	T	PROPN	NNP	Number=Sing	_	_	_	_
23	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
24	death	death	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
25	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 399
# text = Transfection of Jurkat cells with the NF-kappaB subunits p50 and p65 confers resistance against Fas-mediated apoptosis.
1	Transfection	Transfection	NOUN	NN	Number=Sing	_	_	_	_
2	of	of	ADP	IN	_	_	_	_	_
3	Jurkat	Jurkat	PROPN	NNP	Number=Sing	_	_	_	_
4	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
5	with	with	ADP	IN	_	_	_	_	_
6	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
7	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
8	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
9	kappaB	kappaB	PROPN	NNP	Number=Sing	_	_	_	_
10	subunits	subunit	NOUN	NNS	Number=Plur	_	_	_	_
11	p50	p50	NUM	CD	NumType=Card	_	_	_	_
12	and	and	CCONJ	CC	_	_	_	_	_
13	p65	p65	NUM	CD	NumType=Card	_	_	_	_
14	confers	confer	NOUN	NNS	Number=Plur	_	_	_	_
15	resistance	resistance	NOUN	NN	Number=Sing	_	_	_	_
16	against	against	ADP	IN	_	_	_	_	_
17	Fas-	Fas-	PUNCT	:	_	_	_	_	SpaceAfter=No
18	mediated	mediate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
19	apoptosis	apoptosis	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
20	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 400
# text = Reciprocally, inhibition of NF-kappaB activation by a soluble peptide inhibitor or a dominant form of the NF-kappaB inhibitor, IkappaB, makes the cells more susceptible to Fas-mediated apoptosis.
1	Reciprocally	Reciprocally	ADV	RB	_	_	_	_	SpaceAfter=No
2	,	,	PUNCT	,	_	_	_	_	_
3	inhibition	inhibition	NOUN	NN	Number=Sing	_	_	_	_
4	of	of	ADP	IN	_	_	_	_	_
5	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
6	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
7	kappaB	kappaB	PROPN	NNP	Number=Sing	_	_	_	_
8	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
9	by	by	ADP	IN	_	_	_	_	_
10	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
11	soluble	soluble	ADJ	JJ	Degree=Pos	_	_	_	_
12	peptide	peptide	NOUN	NN	Number=Sing	_	_	_	_
13	inhibitor	inhibitor	NOUN	NN	Number=Sing	_	_	_	_
14	or	or	CCONJ	CC	_	_	_	_	_
15	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
16	dominant	dominant	ADJ	JJ	Degree=Pos	_	_	_	_
17	form	form	NOUN	NN	Number=Sing	_	_	_	_
18	of	of	ADP	IN	_	_	_	_	_
19	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
20	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
21	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
22	kappaB	kappaB	PROPN	NNP	Number=Sing	_	_	_	_
23	inhibitor	inhibitor	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
24	,	,	PUNCT	,	_	_	_	_	_
25	IkappaB	Ikappab	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
26	,	,	PUNCT	,	_	_	_	_	_
27	makes	make	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
28	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
29	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
30	more	more	ADV	RBR	_	_	_	_	_
31	susceptible	susceptible	ADJ	JJ	Degree=Pos	_	_	_	_
32	to	to	ADP	IN	_	_	_	_	_
33	Fas-	Fas-	SYM	SYM	_	_	_	_	SpaceAfter=No
34	mediated	mediate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
35	apoptosis	apoptosis	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
36	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 401
# text = Furthermore, inhibition of NF-kappaB activation by a soluble peptide inhibitor rendered a T cell hybridoma more susceptible to TCR-mediated apoptosis.
1	Furthermore	furthermore	ADV	RB	_	_	_	_	SpaceAfter=No
2	,	,	PUNCT	,	_	_	_	_	_
3	inhibition	inhibition	NOUN	NN	Number=Sing	_	_	_	_
4	of	of	ADP	IN	_	_	_	_	_
5	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
6	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
7	kappaB	kappaB	PROPN	NNP	Number=Sing	_	_	_	_
8	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
9	by	by	ADP	IN	_	_	_	_	_
10	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
11	soluble	soluble	ADJ	JJ	Degree=Pos	_	_	_	_
12	peptide	peptide	NOUN	NN	Number=Sing	_	_	_	_
13	inhibitor	inhibitor	NOUN	NN	Number=Sing	_	_	_	_
14	rendered	render	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
15	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
16	T	t	PROPN	NNP	Number=Sing	_	_	_	_
17	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
18	hybridoma	hybridoma	NOUN	NN	Number=Sing	_	_	_	_
19	more	more	ADV	RBR	_	_	_	_	_
20	susceptible	susceptible	ADJ	JJ	Degree=Pos	_	_	_	_
21	to	to	ADP	IN	_	_	_	_	_
22	TCR	TCR	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
23	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
24	mediated	mediate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
25	apoptosis	apoptosis	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
26	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 402
# text = Correspondingly, transfection of p50 and p65 provided considerable protection from TCR-mediated apoptosis.
1	Correspondingly	Correspondingly	ADV	RB	_	_	_	_	SpaceAfter=No
2	,	,	PUNCT	,	_	_	_	_	_
3	transfection	transfection	NOUN	NN	Number=Sing	_	_	_	_
4	of	of	ADP	IN	_	_	_	_	_
5	p50	p50	NUM	CD	NumType=Card	_	_	_	_
6	and	and	CCONJ	CC	_	_	_	_	_
7	p65	p65	NUM	CD	NumType=Card	_	_	_	_
8	provided	provide	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
9	considerable	considerable	ADJ	JJ	Degree=Pos	_	_	_	_
10	protection	protection	NOUN	NN	Number=Sing	_	_	_	_
11	from	from	ADP	IN	_	_	_	_	_
12	TCR	TCR	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
13	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
14	mediated	mediate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
15	apoptosis	apoptosis	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
16	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 403
# text = These observations were corroborated by studies on Fas-mediated death in primary T cells.
1	These	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
2	observations	observation	NOUN	NNS	Number=Plur	_	_	_	_
3	were	be	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
4	corroborated	corroborate	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
5	by	by	ADP	IN	_	_	_	_	_
6	studies	study	NOUN	NNS	Number=Plur	_	_	_	_
7	on	on	ADP	IN	_	_	_	_	_
8	Fas-	Fas-	SYM	SYM	_	_	_	_	SpaceAfter=No
9	mediated	mediate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
10	death	death	NOUN	NN	Number=Sing	_	_	_	_
11	in	in	ADP	IN	_	_	_	_	_
12	primary	primary	ADJ	JJ	Degree=Pos	_	_	_	_
13	T	T	PROPN	NNP	Number=Sing	_	_	_	_
14	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
15	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 404
# text = Concanavalin
1	Concanavalin	Concanavalin	PROPN	NNP	Number=Sing	_	_	_	_

# sent_id = 405
# text = A-activated cycling T cell blasts from mice that are transgenic for the dominant IkappaB molecule have increased sensitivity to Fas-mediated apoptosis, associated with a down-regulation of NF-kappaB complexes in the nucleus.
1	A	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	SpaceAfter=No
2	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
3	activated	activate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
4	cycling	cycling	NOUN	NN	Number=Sing	_	_	_	_
5	T	t	NUM	CD	NumType=Card	_	_	_	_
6	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
7	blasts	blast	NOUN	NNS	Number=Plur	_	_	_	_
8	from	from	ADP	IN	_	_	_	_	_
9	mice	mouse	NOUN	NNS	Number=Plur	_	_	_	_
10	that	that	PRON	WDT	PronType=Rel	_	_	_	_
11	are	be	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
12	transgenic	transgenic	ADJ	JJ	Degree=Pos	_	_	_	_
13	for	for	ADP	IN	_	_	_	_	_
14	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
15	dominant	dominant	ADJ	JJ	Degree=Pos	_	_	_	_
16	IkappaB	IkappaB	NOUN	NN	Number=Sing	_	_	_	_
17	molecule	molecule	NOUN	NN	Number=Sing	_	_	_	_
18	have	have	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
19	increased	increase	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
20	sensitivity	sensitivity	NOUN	NN	Number=Sing	_	_	_	_
21	to	to	ADP	IN	_	_	_	_	_
22	Fas-	Fas-	SYM	NFP	_	_	_	_	SpaceAfter=No
23	mediated	mediate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
24	apoptosis	apoptosis	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
25	,	,	PUNCT	,	_	_	_	_	_
26	associated	associate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
27	with	with	ADP	IN	_	_	_	_	_
28	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
29	down	down	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
30	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
31	regulation	regulation	NOUN	NN	Number=Sing	_	_	_	_
32	of	of	ADP	IN	_	_	_	_	_
33	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
34	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
35	kappaB	kappaB	PROPN	NNP	Number=Sing	_	_	_	_
36	complexes	complex	NOUN	NNS	Number=Plur	_	_	_	_
37	in	in	ADP	IN	_	_	_	_	_
38	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
39	nucleus	nucleus	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
40	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 406
# text = In addition, blocking TNF, itself a positive regulator of NF-kappaB, with neutralizing antibodies renders the cells more susceptible to anti-Fas-mediated apoptosis.
1	In	in	ADP	IN	_	_	_	_	_
2	addition	addition	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
3	,	,	PUNCT	,	_	_	_	_	_
4	blocking	block	VERB	VBG	VerbForm=Ger	_	_	_	_
5	TNF	TNF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
6	,	,	PUNCT	,	_	_	_	_	_
7	itself	itself	PRON	PRP	Case=Acc|Gender=Neut|Number=Sing|Person=3|PronType=Prs|Reflex=Yes	_	_	_	_
8	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
9	positive	positive	ADJ	JJ	Degree=Pos	_	_	_	_
10	regulator	regulator	NOUN	NN	Number=Sing	_	_	_	_
11	of	of	ADP	IN	_	_	_	_	_
12	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
13	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
14	kappaB	kappaB	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
15	,	,	PUNCT	,	_	_	_	_	_
16	with	with	SCONJ	IN	_	_	_	_	_
17	neutralizing	neutralize	VERB	VBG	VerbForm=Ger	_	_	_	_
18	antibodies	antibody	NOUN	NNS	Number=Plur	_	_	_	_
19	renders	render	NOUN	NNS	Number=Plur	_	_	_	_
20	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
21	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
22	more	more	ADV	RBR	_	_	_	_	_
23	susceptible	susceptible	ADJ	JJ	Degree=Pos	_	_	_	_
24	to	to	ADP	IN	_	_	_	_	_
25	anti	anti	X	AFX	_	_	_	_	SpaceAfter=No
26	-Fas-	-Fas-	SYM	SYM	_	_	_	_	SpaceAfter=No
27	mediated	mediate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
28	apoptosis	apoptosis	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
29	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 407
# text = In summary, our results provide compelling evidence that NF-kappaB protects against Fas-mediated death and is likely to be an important regulator of T cell homeostasis and tolerance.
1	In	in	ADP	IN	_	_	_	_	_
2	summary	summary	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
3	,	,	PUNCT	,	_	_	_	_	_
4	our	we	PRON	PRP$	Number=Plur|Person=1|Poss=Yes|PronType=Prs	_	_	_	_
5	results	result	NOUN	NNS	Number=Plur	_	_	_	_
6	provide	provide	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
7	compelling	compelling	ADJ	JJ	Degree=Pos	_	_	_	_
8	evidence	evidence	NOUN	NN	Number=Sing	_	_	_	_
9	that	that	PRON	WDT	PronType=Rel	_	_	_	_
10	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
11	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
12	kappaB	kappaB	PROPN	NNP	Number=Sing	_	_	_	_
13	protects	protect	NOUN	NNS	Number=Plur	_	_	_	_
14	against	against	ADP	IN	_	_	_	_	_
15	Fas-	Fas-	SYM	SYM	_	_	_	_	SpaceAfter=No
16	mediated	mediated	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
17	death	death	NOUN	NN	Number=Sing	_	_	_	_
18	and	and	CCONJ	CC	_	_	_	_	_
19	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
20	likely	likely	ADJ	JJ	Degree=Pos	_	_	_	_
21	to	to	PART	TO	_	_	_	_	_
22	be	be	AUX	VB	VerbForm=Inf	_	_	_	_
23	an	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
24	important	important	ADJ	JJ	Degree=Pos	_	_	_	_
25	regulator	regulator	NOUN	NN	Number=Sing	_	_	_	_
26	of	of	ADP	IN	_	_	_	_	_
27	T	t	PROPN	NNP	Number=Sing	_	_	_	_
28	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
29	homeostasis	homeostasis	NOUN	NN	Number=Sing	_	_	_	_
30	and	and	CCONJ	CC	_	_	_	_	_
31	tolerance	tolerance	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
32	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 408
# text = Document 003002145 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	003002145	003002145	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 409
# text = An IL-2 response element in the human IL-2 receptor alpha chain promoter is a composite element that binds Stat5, Elf-1, HMG-I(Y) and a GATA family protein.
1	An	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
2	IL	Il	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
3	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
4	2	2	NUM	CD	NumType=Card	_	_	_	_
5	response	response	NOUN	NN	Number=Sing	_	_	_	_
6	element	element	NOUN	NN	Number=Sing	_	_	_	_
7	in	in	ADP	IN	_	_	_	_	_
8	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
9	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
10	IL	Il	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
11	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
12	2	2	NUM	CD	NumType=Card	_	_	_	_
13	receptor	receptor	NOUN	NN	Number=Sing	_	_	_	_
14	alpha	alpha	NOUN	NN	Number=Sing	_	_	_	_
15	chain	chain	NOUN	NN	Number=Sing	_	_	_	_
16	promoter	promoter	NOUN	NN	Number=Sing	_	_	_	_
17	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
18	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
19	composite	composite	ADJ	JJ	Degree=Pos	_	_	_	_
20	element	element	NOUN	NN	Number=Sing	_	_	_	_
21	that	that	PRON	WDT	PronType=Rel	_	_	_	_
22	binds	bind	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
23	Stat5	Stat5	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
24	,	,	PUNCT	,	_	_	_	_	_
25	Elf	Elf	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
26	-1	-1	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
27	,	,	PUNCT	,	_	_	_	_	_
28	HMG	Hmg	INTJ	UH	_	_	_	_	SpaceAfter=No
29	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
30	I	I	PRON	PRP	Case=Nom|Number=Sing|Person=1|PronType=Prs	_	_	_	SpaceAfter=No
31	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
32	Y	y	X	FW	Foreign=Yes	_	_	_	SpaceAfter=No
33	)	)	PUNCT	-RRB-	_	_	_	_	_
34	and	and	CCONJ	CC	_	_	_	_	_
35	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
36	GATA	GATa	PROPN	NNP	Number=Sing	_	_	_	_
37	family	family	NOUN	NN	Number=Sing	_	_	_	_
38	protein	protein	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
39	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 410
# text = Expression of the human interleukin-2 (IL-2) receptor alpha chain gene is potently upregulated by its own ligand, IL-2.
1	Expression	expression	NOUN	NN	Number=Sing	_	_	_	_
2	of	of	ADP	IN	_	_	_	_	_
3	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
4	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
5	interleukin	interleukin	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
6	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
7	2	2	NUM	CD	NumType=Card	_	_	_	_
8	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
9	IL	Il	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
10	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
11	2	2	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
12	)	)	PUNCT	-RRB-	_	_	_	_	_
13	receptor	receptor	NOUN	NN	Number=Sing	_	_	_	_
14	alpha	alpha	NOUN	NN	Number=Sing	_	_	_	_
15	chain	chain	NOUN	NN	Number=Sing	_	_	_	_
16	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
17	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
18	potently	potently	ADV	RB	_	_	_	_	_
19	upregulated	upregulate	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
20	by	by	ADP	IN	_	_	_	_	_
21	its	its	PRON	PRP$	Gender=Neut|Number=Sing|Person=3|Poss=Yes|PronType=Prs	_	_	_	_
22	own	own	ADJ	JJ	Degree=Pos	_	_	_	_
23	ligand	ligand	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
24	,	,	PUNCT	,	_	_	_	_	_
25	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
26	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
27	2	2	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
28	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 411
# text = In this study, we characterize an essential upstream IL-2 response element that contains both consensus and non-consensus GAS motifs, two putative Ets binding sites (EBS), one of which overlaps the consensus GAS motif, and a GATA motif, which overlaps the non-consensus GAS motif.
1	In	in	ADP	IN	_	_	_	_	_
2	this	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
3	study	study	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
4	,	,	PUNCT	,	_	_	_	_	_
5	we	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
6	characterize	characterize	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
7	an	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
8	essential	essential	ADJ	JJ	Degree=Pos	_	_	_	_
9	upstream	upstream	NOUN	NN	Number=Sing	_	_	_	_
10	IL	Il	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
11	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
12	2	2	NUM	CD	NumType=Card	_	_	_	_
13	response	response	NOUN	NN	Number=Sing	_	_	_	_
14	element	element	NOUN	NN	Number=Sing	_	_	_	_
15	that	that	PRON	WDT	PronType=Rel	_	_	_	_
16	contains	contain	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
17	both	both	CCONJ	CC	_	_	_	_	_
18	consensus	consensus	NOUN	NN	Number=Sing	_	_	_	_
19	and	and	CCONJ	CC	_	_	_	_	_
20	non-consensus	non-consensus	ADJ	JJ	Degree=Pos	_	_	_	_
21	GAS	gas	NOUN	NNS	Number=Plur	_	_	_	_
22	motifs	motif	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
23	,	,	PUNCT	,	_	_	_	_	_
24	two	two	NUM	CD	NumType=Card	_	_	_	_
25	putative	putative	ADJ	JJ	Degree=Pos	_	_	_	_
26	Ets	Et	NOUN	NNS	Number=Plur	_	_	_	_
27	binding	bind	VERB	VBG	VerbForm=Ger	_	_	_	_
28	sites	site	NOUN	NNS	Number=Plur	_	_	_	_
29	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
30	EBS	EBS	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
31	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
32	,	,	PUNCT	,	_	_	_	_	_
33	one	one	NUM	CD	NumType=Card	_	_	_	_
34	of	of	ADP	IN	_	_	_	_	_
35	which	which	PRON	WDT	PronType=Rel	_	_	_	_
36	overlaps	overlaps	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
37	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
38	consensus	consensus	NOUN	NN	Number=Sing	_	_	_	_
39	GAS	gas	NOUN	NN	Number=Sing	_	_	_	_
40	motif	motif	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
41	,	,	PUNCT	,	_	_	_	_	_
42	and	and	CCONJ	CC	_	_	_	_	_
43	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
44	GATA	GATa	PROPN	NNP	Number=Sing	_	_	_	_
45	motif	motif	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
46	,	,	PUNCT	,	_	_	_	_	_
47	which	which	PRON	WDT	PronType=Rel	_	_	_	_
48	overlaps	overlaps	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
49	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
50	non-consensus	non-consensus	ADJ	JJ	Degree=Pos	_	_	_	_
51	GAS	gas	NOUN	NN	Number=Sing	_	_	_	_
52	motif	motif	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
53	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 412
# text = We demonstrate that although the individual components of this element do not respond to IL-2, together they form a composite element capable of conferring IL-2 responsiveness to a heterologous promoter.
1	We	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
2	demonstrate	demonstrate	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
3	that	that	SCONJ	IN	_	_	_	_	_
4	although	although	SCONJ	IN	_	_	_	_	_
5	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
6	individual	individual	ADJ	JJ	Degree=Pos	_	_	_	_
7	components	component	NOUN	NNS	Number=Plur	_	_	_	_
8	of	of	ADP	IN	_	_	_	_	_
9	this	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
10	element	element	NOUN	NN	Number=Sing	_	_	_	_
11	do	do	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
12	not	not	PART	RB	_	_	_	_	_
13	respond	respond	VERB	VB	VerbForm=Inf	_	_	_	_
14	to	to	ADP	IN	_	_	_	_	_
15	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
16	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
17	2	2	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
18	,	,	PUNCT	,	_	_	_	_	_
19	together	together	SCONJ	IN	_	_	_	_	_
20	they	they	PRON	PRP	Case=Nom|Number=Plur|Person=3|PronType=Prs	_	_	_	_
21	form	form	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
22	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
23	composite	composite	NOUN	NN	Number=Sing	_	_	_	_
24	element	element	NOUN	NN	Number=Sing	_	_	_	_
25	capable	capable	ADJ	JJ	Degree=Pos	_	_	_	_
26	of	of	SCONJ	IN	_	_	_	_	_
27	conferring	conferr	VERB	VBG	VerbForm=Ger	_	_	_	_
28	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
29	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
30	2	2	NUM	CD	NumType=Card	_	_	_	_
31	responsiveness	responsiveness	NOUN	NN	Number=Sing	_	_	_	_
32	to	to	ADP	IN	_	_	_	_	_
33	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
34	heterologous	heterologous	ADJ	JJ	Degree=Pos	_	_	_	_
35	promoter	promoter	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
36	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 413
# text = Multiple factors including Stat5, Elf-1, HMG-I(Y) and GATA family proteins bind to the IL-2 response element and mutation of any one of these binding sites diminishes the activity of this element.
1	Multiple	multiple	ADJ	JJ	Degree=Pos	_	_	_	_
2	factors	factor	NOUN	NNS	Number=Plur	_	_	_	_
3	including	include	VERB	VBG	VerbForm=Ger	_	_	_	_
4	Stat5	Stat5	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
5	,	,	PUNCT	,	_	_	_	_	_
6	Elf	Elf	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
7	-1	-1	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
8	,	,	PUNCT	,	_	_	_	_	_
9	HMG	Hmg	INTJ	UH	_	_	_	_	SpaceAfter=No
10	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
11	I	I	PRON	PRP	Case=Nom|Number=Sing|Person=1|PronType=Prs	_	_	_	SpaceAfter=No
12	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
13	Y	y	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
14	)	)	PUNCT	-RRB-	_	_	_	_	_
15	and	and	CCONJ	CC	_	_	_	_	_
16	GATA	GATA	PROPN	NNP	Number=Sing	_	_	_	_
17	family	family	NOUN	NN	Number=Sing	_	_	_	_
18	proteins	protein	NOUN	NNS	Number=Plur	_	_	_	_
19	bind	bind	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
20	to	to	ADP	IN	_	_	_	_	_
21	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
22	IL	Il	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
23	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
24	2	2	NUM	CD	NumType=Card	_	_	_	_
25	response	response	NOUN	NN	Number=Sing	_	_	_	_
26	element	element	NOUN	NN	Number=Sing	_	_	_	_
27	and	and	CCONJ	CC	_	_	_	_	_
28	mutation	mutation	NOUN	NN	Number=Sing	_	_	_	_
29	of	of	ADP	IN	_	_	_	_	_
30	any	any	DET	DT	_	_	_	_	_
31	one	one	NUM	CD	NumType=Card	_	_	_	_
32	of	of	ADP	IN	_	_	_	_	_
33	these	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
34	binding	binding	VERB	VBG	VerbForm=Ger	_	_	_	_
35	sites	site	NOUN	NNS	Number=Plur	_	_	_	_
36	diminishes	diminish	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
37	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
38	activity	activity	NOUN	NN	Number=Sing	_	_	_	_
39	of	of	ADP	IN	_	_	_	_	_
40	this	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
41	element	element	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
42	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 414
# text = An unidentified Ets family protein binds to the EBS overlapping the consensus GAS motif and appears to negatively regulate the human IL-2R alpha promoter.
1	An	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
2	unidentified	unidentified	ADJ	JJ	Degree=Pos	_	_	_	_
3	Ets	Ets	NOUN	NNS	Number=Plur	_	_	_	_
4	family	family	NOUN	NN	Number=Sing	_	_	_	_
5	protein	protein	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
6	binds	bind	NOUN	NNS	Number=Plur	_	_	_	_
7	to	to	ADP	IN	_	_	_	_	_
8	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
9	EBS	Eb	PROPN	NNP	Number=Sing	_	_	_	_
10	overlapping	overlapp	VERB	VBG	VerbForm=Ger	_	_	_	_
11	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
12	consensus	consensus	NOUN	NN	Number=Sing	_	_	_	_
13	GAS	gas	NOUN	NN	Number=Sing	_	_	_	_
14	motif	motif	NOUN	NN	Number=Sing	_	_	_	_
15	and	and	CCONJ	CC	_	_	_	_	_
16	appears	appear	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
17	to	to	PART	TO	_	_	_	_	_
18	negatively	negatively	ADV	RB	_	_	_	_	_
19	regulate	regulate	VERB	VB	VerbForm=Inf	_	_	_	_
20	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
21	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
22	IL	Il	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
23	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
24	2	2	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
25	R	r	NOUN	NN	Number=Sing	_	_	_	_
26	alpha	alpha	ADP	IN	_	_	_	_	_
27	promoter	promoter	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
28	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 415
# text = Thus, IL-2-induced IL-2R alpha promoter activity requires a complex upstream element, which appears to contain binding sites for both positive and negative regulatory factors.
1	Thus	thus	ADV	RB	_	_	_	_	SpaceAfter=No
2	,	,	PUNCT	,	_	_	_	_	_
3	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
4	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
5	2	2	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
6	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
7	induced	induce	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
8	IL	Il	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
9	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
10	2R	2r	PROPN	NNP	Number=Sing	_	_	_	_
11	alpha	alpha	NOUN	NN	Number=Sing	_	_	_	_
12	promoter	promoter	NOUN	NN	Number=Sing	_	_	_	_
13	activity	activity	NOUN	NN	Number=Sing	_	_	_	_
14	requires	require	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
15	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
16	complex	complex	ADJ	JJ	Degree=Pos	_	_	_	_
17	upstream	upstream	NOUN	NN	Number=Sing	_	_	_	_
18	element	element	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
19	,	,	PUNCT	,	_	_	_	_	_
20	which	which	PRON	WDT	PronType=Rel	_	_	_	_
21	appears	appear	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
22	to	to	PART	TO	_	_	_	_	_
23	contain	contain	VERB	VB	VerbForm=Inf	_	_	_	_
24	binding	bind	VERB	VBG	VerbForm=Ger	_	_	_	_
25	sites	site	NOUN	NNS	Number=Plur	_	_	_	_
26	for	for	ADP	IN	_	_	_	_	_
27	both	both	CCONJ	CC	_	_	_	_	_
28	positive	positive	ADJ	JJ	Degree=Pos	_	_	_	_
29	and	and	CCONJ	CC	_	_	_	_	_
30	negative	negative	ADJ	JJ	Degree=Pos	_	_	_	_
31	regulatory	regulatory	ADJ	JJ	Degree=Pos	_	_	_	_
32	factors	factor	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
33	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 416
# text = Document 003002146 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	003002146	003002146	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 417
# text = Genomic organization, sequence, and transcriptional regulation of the human eotaxin gene.
1	Genomic	Genomic	ADJ	JJ	Degree=Pos	_	_	_	_
2	organization	organization	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
3	,	,	PUNCT	,	_	_	_	_	_
4	sequence	sequence	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
5	,	,	PUNCT	,	_	_	_	_	_
6	and	and	CCONJ	CC	_	_	_	_	_
7	transcriptional	transcriptional	ADJ	JJ	Degree=Pos	_	_	_	_
8	regulation	regulation	NOUN	NN	Number=Sing	_	_	_	_
9	of	of	ADP	IN	_	_	_	_	_
10	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
11	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
12	eotaxin	eotaxin	NOUN	NN	Number=Sing	_	_	_	_
13	gene	gene	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
14	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 418
# text = Eotaxin is an eosinophil specific beta-chemokine assumed to be involved in eosinophilic inflammatory diseases such as atopic dermatitis, allergic rhinitis, asthma and parasitic infections.
1	Eotaxin	Eotaxin	PROPN	NNP	Number=Sing	_	_	_	_
2	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
3	an	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
4	eosinophil	eosinophil	ADJ	JJ	Degree=Pos	_	_	_	_
5	specific	specific	ADJ	JJ	Degree=Pos	_	_	_	_
6	beta	beta	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
7	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
8	chemokine	chemokine	NOUN	NN	Number=Sing	_	_	_	_
9	assumed	assume	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
10	to	to	PART	TO	_	_	_	_	_
11	be	be	AUX	VB	VerbForm=Inf	_	_	_	_
12	involved	involved	ADJ	JJ	Degree=Pos	_	_	_	_
13	in	in	ADP	IN	_	_	_	_	_
14	eosinophilic	eosinophilic	ADJ	JJ	Degree=Pos	_	_	_	_
15	inflammatory	inflammatory	ADJ	JJ	Degree=Pos	_	_	_	_
16	diseases	diseasis	NOUN	NNS	Number=Plur	_	_	_	_
17	such	such	ADJ	JJ	Degree=Pos	_	_	_	_
18	as	as	ADP	IN	_	_	_	_	_
19	atopic	atopic	ADJ	JJ	Degree=Pos	_	_	_	_
20	dermatitis	dermatitis	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
21	,	,	PUNCT	,	_	_	_	_	_
22	allergic	allergic	ADJ	JJ	Degree=Pos	_	_	_	_
23	rhinitis	rhinitis	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
24	,	,	PUNCT	,	_	_	_	_	_
25	asthma	asthma	NOUN	NN	Number=Sing	_	_	_	_
26	and	and	CCONJ	CC	_	_	_	_	_
27	parasitic	parasitic	ADJ	JJ	Degree=Pos	_	_	_	_
28	infections	infection	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
29	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 419
# text = Its expression is stimulus- and cell-specific.
1	Its	its	PRON	PRP$	Gender=Neut|Number=Sing|Person=3|Poss=Yes|PronType=Prs	_	_	_	_
2	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
3	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
4	stimulus	stimulus	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
5	-	-	PUNCT	,	_	_	_	_	_
6	and	and	CCONJ	CC	_	_	_	_	_
7	cell	cell	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
8	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
9	specific	specific	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
10	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 420
# text = We here describe the genomic organisation (3 exons of 132, 112 and 542 bp and 2 introns of 1211 and 378 bp) and sequence including 3 kb of DNA from the immediate 5' upstream region of the human eotaxin gene.
1	We	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
2	here	here	ADV	RB	PronType=Dem	_	_	_	_
3	describe	describe	VERB	VB	VerbForm=Inf	_	_	_	_
4	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
5	genomic	genomic	ADJ	JJ	Degree=Pos	_	_	_	_
6	organisation	organisation	NOUN	NN	Number=Sing	_	_	_	_
7	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
8	3	3	NUM	CD	NumType=Card	_	_	_	_
9	exons	exon	NOUN	NNS	Number=Plur	_	_	_	_
10	of	of	ADP	IN	_	_	_	_	_
11	132	132	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
12	,	,	PUNCT	,	_	_	_	_	_
13	112	112	NUM	CD	NumType=Card	_	_	_	_
14	and	and	CCONJ	CC	_	_	_	_	_
15	542	542	NUM	CD	NumType=Card	_	_	_	_
16	bp	bp	NOUN	NN	Number=Sing	_	_	_	_
17	and	and	CCONJ	CC	_	_	_	_	_
18	2	2	NUM	CD	NumType=Card	_	_	_	_
19	introns	intron	NOUN	NNS	Number=Plur	_	_	_	_
20	of	of	ADP	IN	_	_	_	_	_
21	1211	1211	NUM	CD	NumType=Card	_	_	_	_
22	and	and	CCONJ	CC	_	_	_	_	_
23	378	378	NUM	CD	NumType=Card	_	_	_	_
24	bp	bp	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
25	)	)	PUNCT	-RRB-	_	_	_	_	_
26	and	and	CCONJ	CC	_	_	_	_	_
27	sequence	sequence	NOUN	NN	Number=Sing	_	_	_	_
28	including	include	VERB	VBG	VerbForm=Ger	_	_	_	_
29	3	3	NUM	CD	NumType=Card	_	_	_	_
30	kb	kb	NOUN	NN	Number=Sing	_	_	_	_
31	of	of	ADP	IN	_	_	_	_	_
32	DNA	dna	NOUN	NN	Number=Sing	_	_	_	_
33	from	from	ADP	IN	_	_	_	_	_
34	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
35	immediate	immediate	ADJ	JJ	Degree=Pos	_	_	_	_
36	5	5	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
37	'	'	PUNCT	``	_	_	_	_	_
38	upstream	upstream	NOUN	NN	Number=Sing	_	_	_	_
39	region	region	NOUN	NN	Number=Sing	_	_	_	_
40	of	of	ADP	IN	_	_	_	_	_
41	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
42	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
43	eotaxin	eotaxin	NOUN	NN	Number=Sing	_	_	_	_
44	gene	gene	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
45	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 421
# text = Among the regulatory promoter elements potentially regulating eotaxin gene expression and/or mediating the effects of anti-inflammatory drugs we identified consensus sequences known to interact with nuclear factors like NF-IL6, AP-1, a NF-kappa-B like consensus sequence and gamma-interferon- as well as glucocorticoid response elements.
1	Among	among	ADP	IN	_	_	_	_	_
2	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
3	regulatory	regulatory	ADJ	JJ	Degree=Pos	_	_	_	_
4	promoter	promoter	NOUN	NN	Number=Sing	_	_	_	_
5	elements	element	NOUN	NNS	Number=Plur	_	_	_	_
6	potentially	potentially	ADV	RB	_	_	_	_	_
7	regulating	regulate	VERB	VBG	VerbForm=Ger	_	_	_	_
8	eotaxin	eotaxin	ADP	IN	_	_	_	_	_
9	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
10	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
11	and	and	CCONJ	CC	_	_	_	_	SpaceAfter=No
12	/	/	PUNCT	,	_	_	_	_	SpaceAfter=No
13	or	or	CCONJ	CC	_	_	_	_	_
14	mediating	mediat	VERB	VBG	VerbForm=Ger	_	_	_	_
15	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
16	effects	effect	NOUN	NNS	Number=Plur	_	_	_	_
17	of	of	ADP	IN	_	_	_	_	_
18	anti-inflammatory	anti-inflammatory	ADJ	JJ	Degree=Pos	_	_	_	_
19	drugs	drug	NOUN	NNS	Number=Plur	_	_	_	_
20	we	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
21	identified	identify	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
22	consensus	consensus	NOUN	NN	Number=Sing	_	_	_	_
23	sequences	sequence	NOUN	NNS	Number=Plur	_	_	_	_
24	known	know	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
25	to	to	PART	TO	_	_	_	_	_
26	interact	interact	VERB	VB	VerbForm=Inf	_	_	_	_
27	with	with	ADP	IN	_	_	_	_	_
28	nuclear	nuclear	ADJ	JJ	Degree=Pos	_	_	_	_
29	factors	factor	NOUN	NNS	Number=Plur	_	_	_	_
30	like	like	ADP	IN	_	_	_	_	_
31	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
32	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
33	IL6	Il6	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
34	,	,	PUNCT	,	_	_	_	_	_
35	AP	ap	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
36	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
37	1	1	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
38	,	,	PUNCT	,	_	_	_	_	_
39	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
40	NF	NF	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
41	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
42	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
43	-B	-b	NOUN	NN	Number=Sing	_	_	_	_
44	like	like	ADP	IN	_	_	_	_	_
45	consensus	consensus	NOUN	NN	Number=Sing	_	_	_	_
46	sequence	sequence	NOUN	NN	Number=Sing	_	_	_	_
47	and	and	CCONJ	CC	_	_	_	_	_
48	gamma	gamma	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
49	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
50	interferon	interferon	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
51	-	-	PUNCT	HYPH	_	_	_	_	_
52	as	as	ADV	RB	_	_	_	_	_
53	well	well	ADV	RB	Degree=Pos	_	_	_	_
54	as	as	ADP	IN	_	_	_	_	_
55	glucocorticoid	glucocorticoid	ADJ	JJ	Degree=Pos	_	_	_	_
56	response	response	NOUN	NN	Number=Sing	_	_	_	_
57	elements	element	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
58	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 422
# text = Document 003002148 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	003002148	003002148	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 423
# text = Calcium-dependent immediate-early gene induction in lymphocytes is negatively regulated by p21Ha-ras.
1	Calcium	calcium	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
2	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
3	dependent	dependent	ADJ	JJ	Degree=Pos	_	_	_	_
4	immediate	immediate	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
5	-early	-early	ADJ	JJ	Degree=Pos	_	_	_	_
6	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
7	induction	induction	NOUN	NN	Number=Sing	_	_	_	_
8	in	in	ADP	IN	_	_	_	_	_
9	lymphocytes	lymphocyte	NOUN	NNS	Number=Plur	_	_	_	_
10	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
11	negatively	negatively	ADV	RB	_	_	_	_	_
12	regulated	regulate	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
13	by	by	ADP	IN	_	_	_	_	_
14	p21Ha	p21Ha	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
15	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
16	ras	ra	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
17	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 424
# text = The induction of immediate-early (IE) response genes, such as egr-1, c-fos, and c-jun, occurs rapidly after the activation of T lymphocytes.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	induction	induction	NOUN	NN	Number=Sing	_	_	_	_
3	of	of	ADP	IN	_	_	_	_	_
4	immediate	immediate	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
5	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
6	early	early	ADJ	JJ	Degree=Pos	_	_	_	_
7	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
8	IE	ie	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
9	)	)	PUNCT	-RRB-	_	_	_	_	_
10	response	response	NOUN	NN	Number=Sing	_	_	_	_
11	genes	gene	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
12	,	,	PUNCT	,	_	_	_	_	_
13	such	such	ADJ	JJ	Degree=Pos	_	_	_	_
14	as	as	ADP	IN	_	_	_	_	_
15	egr	egr	ADJ	JJR	Degree=Cmp	_	_	_	SpaceAfter=No
16	-1	-1	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
17	,	,	PUNCT	,	_	_	_	_	_
18	c-	c-	PUNCT	:	_	_	_	_	SpaceAfter=No
19	fos	fo	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
20	,	,	PUNCT	,	_	_	_	_	_
21	and	and	CCONJ	CC	_	_	_	_	_
22	c-	c-	SYM	NFP	_	_	_	_	SpaceAfter=No
23	jun	jun	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
24	,	,	PUNCT	,	_	_	_	_	_
25	occurs	occurs	NOUN	NNS	Number=Plur	_	_	_	_
26	rapidly	rapidly	ADV	RB	_	_	_	_	_
27	after	after	ADP	IN	_	_	_	_	_
28	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
29	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
30	of	of	ADP	IN	_	_	_	_	_
31	T	t	PROPN	NNP	Number=Sing	_	_	_	_
32	lymphocytes	lymphocyte	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
33	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 425
# text = The process of activation involves calcium mobilization, activation of protein kinase C (PKC), and phosphorylation of tyrosine kinases.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	process	process	NOUN	NN	Number=Sing	_	_	_	_
3	of	of	ADP	IN	_	_	_	_	_
4	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
5	involves	involf	NOUN	NNS	Number=Plur	_	_	_	_
6	calcium	calcium	NOUN	NN	Number=Sing	_	_	_	_
7	mobilization	mobilization	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
8	,	,	PUNCT	,	_	_	_	_	_
9	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
10	of	of	ADP	IN	_	_	_	_	_
11	protein	protein	NOUN	NN	Number=Sing	_	_	_	_
12	kinase	kinase	NOUN	NN	Number=Sing	_	_	_	_
13	C	C	PROPN	NNP	Number=Sing	_	_	_	_
14	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
15	PKC	PKC	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
16	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
17	,	,	PUNCT	,	_	_	_	_	_
18	and	and	CCONJ	CC	_	_	_	_	_
19	phosphorylation	phosphorylation	NOUN	NN	Number=Sing	_	_	_	_
20	of	of	ADP	IN	_	_	_	_	_
21	tyrosine	tyrosine	NOUN	NN	Number=Sing	_	_	_	_
22	kinases	kinase	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
23	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 426
# text = p21(ras), a guanine nucleotide binding factor, mediates T-cell signal transduction through PKC-dependent and PKC-independent pathways.
1	p21	p21	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
2	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
3	ras	ra	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
5	,	,	PUNCT	,	_	_	_	_	_
6	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
7	guanine	guanine	NOUN	NN	Number=Sing	_	_	_	_
8	nucleotide	nucleotide	NOUN	NN	Number=Sing	_	_	_	_
9	binding	bind	VERB	VBG	VerbForm=Ger	_	_	_	_
10	factor	factor	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
11	,	,	PUNCT	,	_	_	_	_	_
12	mediates	mediate	NOUN	NNS	Number=Plur	_	_	_	_
13	T-	T-	PUNCT	:	_	_	_	_	SpaceAfter=No
14	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
15	signal	signal	NOUN	NN	Number=Sing	_	_	_	_
16	transduction	transduction	NOUN	NN	Number=Sing	_	_	_	_
17	through	through	ADP	IN	_	_	_	_	_
18	PKC	PKC	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
19	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
20	dependent	dependent	ADJ	JJ	Degree=Pos	_	_	_	_
21	and	and	CCONJ	CC	_	_	_	_	_
22	PKC	Pkc	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
23	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
24	independent	independent	ADJ	JJ	Degree=Pos	_	_	_	_
25	pathways	pathway	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
26	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 427
# text = The involvement of p21(ras) in the regulation of calcium-dependent signals has been suggested through analysis of its role in the activation of NF-AT.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	involvement	involvement	NOUN	NN	Number=Sing	_	_	_	_
3	of	of	ADP	IN	_	_	_	_	_
4	p21	p21	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
5	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
6	ras	ra	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
7	)	)	PUNCT	-RRB-	_	_	_	_	_
8	in	in	ADP	IN	_	_	_	_	_
9	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
10	regulation	regulation	NOUN	NN	Number=Sing	_	_	_	_
11	of	of	ADP	IN	_	_	_	_	_
12	calcium	calcium	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
13	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
14	dependent	dependent	ADJ	JJ	Degree=Pos	_	_	_	_
15	signals	signal	NOUN	NNS	Number=Plur	_	_	_	_
16	has	have	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
17	been	be	AUX	VBN	Tense=Past|VerbForm=Part	_	_	_	_
18	suggested	suggest	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
19	through	through	ADP	IN	_	_	_	_	_
20	analysis	analysis	NOUN	NN	Number=Sing	_	_	_	_
21	of	of	ADP	IN	_	_	_	_	_
22	its	its	PRON	PRP$	Gender=Neut|Number=Sing|Person=3|Poss=Yes|PronType=Prs	_	_	_	_
23	role	role	NOUN	NN	Number=Sing	_	_	_	_
24	in	in	ADP	IN	_	_	_	_	_
25	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
26	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
27	of	of	ADP	IN	_	_	_	_	_
28	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
29	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
30	AT	at	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
31	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 428
# text = We have investigated the inductions of the IE genes in response to calcium signals in Jurkat cells (in the presence of activated p21(ras)) and their correlated consequences.
1	We	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
2	have	have	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
3	investigated	investigate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
4	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
5	inductions	induction	NOUN	NNS	Number=Plur	_	_	_	_
6	of	of	ADP	IN	_	_	_	_	_
7	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
8	IE	ie	ADJ	JJ	Degree=Pos	_	_	_	_
9	genes	gene	NOUN	NNS	Number=Plur	_	_	_	_
10	in	in	ADP	IN	_	_	_	_	_
11	response	response	NOUN	NN	Number=Sing	_	_	_	_
12	to	to	PART	TO	_	_	_	_	_
13	calcium	calcium	VERB	VB	VerbForm=Inf	_	_	_	_
14	signals	signal	NOUN	NNS	Number=Plur	_	_	_	_
15	in	in	ADP	IN	_	_	_	_	_
16	Jurkat	Jurkat	PROPN	NNP	Number=Sing	_	_	_	_
17	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
18	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
19	in	in	ADP	IN	_	_	_	_	_
20	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
21	presence	presence	NOUN	NN	Number=Sing	_	_	_	_
22	of	of	ADP	IN	_	_	_	_	_
23	activated	activate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
24	p21	p21	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
25	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
26	ras	ra	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
27	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
28	)	)	PUNCT	-RRB-	_	_	_	_	_
29	and	and	CCONJ	CC	_	_	_	_	_
30	their	they	PRON	PRP$	Number=Plur|Person=3|Poss=Yes|PronType=Prs	_	_	_	_
31	correlated	correlate	ADJ	JJ	Degree=Pos	_	_	_	_
32	consequences	consequences	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
33	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 429
# text = The expression of activated p21(ras) negatively regulated the induction of IE genes by calcium ionophore.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
3	of	of	ADP	IN	_	_	_	_	_
4	activated	activated	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
5	p21	p21	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
6	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
7	ras	ra	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
8	)	)	PUNCT	-RRB-	_	_	_	_	_
9	negatively	negatively	ADV	RB	_	_	_	_	_
10	regulated	regulate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
11	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
12	induction	induction	NOUN	NN	Number=Sing	_	_	_	_
13	of	of	ADP	IN	_	_	_	_	_
14	IE	ie	ADJ	JJ	Degree=Pos	_	_	_	_
15	genes	gene	NOUN	NNS	Number=Plur	_	_	_	_
16	by	by	ADP	IN	_	_	_	_	_
17	calcium	calcium	NOUN	NN	Number=Sing	_	_	_	_
18	ionophore	ionophore	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
19	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 430
# text = This inhibition of calcium-activated IE gene induction was reversed by treatment with cyclosporin A, suggesting the involvement of calcineurin in this regulation.
1	This	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
2	inhibition	inhibition	NOUN	NN	Number=Sing	_	_	_	_
3	of	of	ADP	IN	_	_	_	_	_
4	calcium-	calcium-	PUNCT	:	_	_	_	_	SpaceAfter=No
5	activated	activate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
6	IE	ie	ADJ	JJ	Degree=Pos	_	_	_	_
7	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
8	induction	induction	NOUN	NN	Number=Sing	_	_	_	_
9	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
10	reversed	reverse	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
11	by	by	ADP	IN	_	_	_	_	_
12	treatment	treatment	NOUN	NN	Number=Sing	_	_	_	_
13	with	with	ADP	IN	_	_	_	_	_
14	cyclosporin	cyclosporin	NOUN	NN	Number=Sing	_	_	_	_
15	A	a	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
16	,	,	PUNCT	,	_	_	_	_	_
17	suggesting	suggest	VERB	VBG	VerbForm=Ger	_	_	_	_
18	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
19	involvement	involvement	NOUN	NN	Number=Sing	_	_	_	_
20	of	of	ADP	IN	_	_	_	_	_
21	calcineurin	calcineurin	NOUN	NN	Number=Sing	_	_	_	_
22	in	in	ADP	IN	_	_	_	_	_
23	this	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
24	regulation	regulation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
25	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 431
# text = A later result of inhibition of this activation pathway by p21(ras) was down-regulation of the activity of the transcription factor AP-1 and subsequent coordinate reductions in IL-2 gene expression and protein production.
1	A	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
2	later	later	ADJ	JJ	Degree=Pos	_	_	_	_
3	result	result	NOUN	NN	Number=Sing	_	_	_	_
4	of	of	ADP	IN	_	_	_	_	_
5	inhibition	inhibition	NOUN	NN	Number=Sing	_	_	_	_
6	of	of	ADP	IN	_	_	_	_	_
7	this	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
8	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
9	pathway	pathway	NOUN	NN	Number=Sing	_	_	_	_
10	by	by	ADP	IN	_	_	_	_	_
11	p21	p21	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
12	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
13	ras	ras	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
14	)	)	PUNCT	-RRB-	_	_	_	_	_
15	was	be	VERB	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
16	down	down	ADV	RB	_	_	_	_	SpaceAfter=No
17	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
18	regulation	regulation	NOUN	NN	Number=Sing	_	_	_	_
19	of	of	ADP	IN	_	_	_	_	_
20	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
21	activity	activity	NOUN	NN	Number=Sing	_	_	_	_
22	of	of	ADP	IN	_	_	_	_	_
23	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
24	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
25	factor	factor	NOUN	NN	Number=Sing	_	_	_	_
26	AP	ap	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
27	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
28	1	1	NUM	CD	NumType=Card	_	_	_	_
29	and	and	CCONJ	CC	_	_	_	_	_
30	subsequent	subsequent	ADJ	JJ	Degree=Pos	_	_	_	_
31	coordinate	coordinate	ADJ	JJ	Degree=Pos	_	_	_	_
32	reductions	reduction	NOUN	NNS	Number=Plur	_	_	_	_
33	in	in	ADP	IN	_	_	_	_	_
34	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
35	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
36	2	2	NUM	CD	NumType=Card	_	_	_	_
37	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
38	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
39	and	and	CCONJ	CC	_	_	_	_	_
40	protein	protein	NOUN	NN	Number=Sing	_	_	_	_
41	production	production	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
42	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 432
# text = These results suggest that p2l(ras) is an essential mediator in generating not only positive but also negative modulatory mechanisms controlling the competence of T cells in response to inductive stimulations.
1	These	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
2	results	result	NOUN	NNS	Number=Plur	_	_	_	_
3	suggest	suggest	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
4	that	that	SCONJ	IN	_	_	_	_	_
5	p2l(	p2l(	SYM	NFP	_	_	_	_	SpaceAfter=No
6	ras	ra	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
7	)	)	PUNCT	-RRB-	_	_	_	_	_
8	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
9	an	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
10	essential	essential	ADJ	JJ	Degree=Pos	_	_	_	_
11	mediator	mediator	NOUN	NN	Number=Sing	_	_	_	_
12	in	in	SCONJ	IN	_	_	_	_	_
13	generating	generate	VERB	VBG	VerbForm=Ger	_	_	_	_
14	not	not	ADV	RB	_	_	_	_	_
15	only	only	ADV	RB	_	_	_	_	_
16	positive	positive	ADJ	JJ	Degree=Pos	_	_	_	_
17	but	but	CCONJ	CC	_	_	_	_	_
18	also	also	ADV	RB	_	_	_	_	_
19	negative	negative	ADJ	JJ	Degree=Pos	_	_	_	_
20	modulatory	modulatory	ADJ	JJ	Degree=Pos	_	_	_	_
21	mechanisms	mechanism	NOUN	NNS	Number=Plur	_	_	_	_
22	controlling	controlle	VERB	VBG	VerbForm=Ger	_	_	_	_
23	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
24	competence	competence	NOUN	NN	Number=Sing	_	_	_	_
25	of	of	ADP	IN	_	_	_	_	_
26	T	t	PROPN	NNP	Number=Sing	_	_	_	_
27	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
28	in	in	ADP	IN	_	_	_	_	_
29	response	response	NOUN	NN	Number=Sing	_	_	_	_
30	to	to	ADP	IN	_	_	_	_	_
31	inductive	inductive	ADJ	JJ	Degree=Pos	_	_	_	_
32	stimulations	stimulation	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
33	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 433
# text = Document 003002155 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	003002155	003002155	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 434
# text = NF-X2 that binds to the DRA X2-box is activator protein 1.
1	NF	Nf	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
2	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
3	X2	x2	NOUN	NN	Number=Sing	_	_	_	_
4	that	that	PRON	WDT	PronType=Rel	_	_	_	_
5	binds	bind	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
6	to	to	ADP	IN	_	_	_	_	_
7	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
8	DRA	DRa	PROPN	NNP	Number=Sing	_	_	_	_
9	X2	X2	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
10	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
11	box	box	NOUN	NN	Number=Sing	_	_	_	_
12	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
13	activator	activator	NOUN	NN	Number=Sing	_	_	_	_
14	protein	protein	NOUN	NN	Number=Sing	_	_	_	_
15	1	1	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
16	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 435
# text = Expression cloning of c-Jun.
1	Expression	expression	NOUN	NN	Number=Sing	_	_	_	_
2	cloning	cloning	NOUN	NN	Number=Sing	_	_	_	_
3	of	of	ADP	IN	_	_	_	_	_
4	c	c	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
5	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
6	Jun	Jun	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
7	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 436
# text = Human class II MHC
1	Human	human	ADJ	JJ	Degree=Pos	_	_	_	_
2	class	class	NOUN	NN	Number=Sing	_	_	_	_
3	II	ii	NUM	CD	NumType=Card	_	_	_	_
4	MHC	MHC	PROPN	NNP	Number=Sing	_	_	_	_

# sent_id = 437
# text = Ag are a family of cell surface glycoproteins.
1	Ag	ag	NOUN	NN	Number=Sing	_	_	_	_
2	are	be	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
3	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
4	family	family	NOUN	NN	Number=Sing	_	_	_	_
5	of	of	ADP	IN	_	_	_	_	_
6	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
7	surface	surface	NOUN	NN	Number=Sing	_	_	_	_
8	glycoproteins	glycoprotein	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
9	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 438
# text = Their constitutive expression is limited to B lymphocytes and thymic epithelial cells.
1	Their	they	PRON	PRP$	Number=Plur|Person=3|Poss=Yes|PronType=Prs	_	_	_	_
2	constitutive	constitutive	ADJ	JJ	Degree=Pos	_	_	_	_
3	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
4	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
5	limited	limited	ADJ	JJ	Degree=Pos	_	_	_	_
6	to	to	ADP	IN	_	_	_	_	_
7	B	b	ADJ	JJ	Degree=Pos	_	_	_	_
8	lymphocytes	lymphocyte	NOUN	NNS	Number=Plur	_	_	_	_
9	and	and	CCONJ	CC	_	_	_	_	_
10	thymic	thymic	ADJ	JJ	Degree=Pos	_	_	_	_
11	epithelial	epithelial	ADJ	JJ	Degree=Pos	_	_	_	_
12	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
13	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 439
# text = In many other cells their expression can be induced by IFN-gamma.
1	In	in	ADP	IN	_	_	_	_	_
2	many	many	ADJ	JJ	Degree=Pos	_	_	_	_
3	other	other	ADJ	JJ	Degree=Pos	_	_	_	_
4	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
5	their	they	PRON	PRP$	Number=Plur|Person=3|Poss=Yes|PronType=Prs	_	_	_	_
6	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
7	can	can	AUX	MD	VerbForm=Fin	_	_	_	_
8	be	be	AUX	VB	VerbForm=Inf	_	_	_	_
9	induced	induce	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
10	by	by	ADP	IN	_	_	_	_	_
11	IFN	IFN	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
12	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
13	gamma	gamma	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
14	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 440
# text = Conserved upstream promoter sequences regulate this tissue-specific expression of class II genes.
1	Conserved	Conserve	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
2	upstream	upstream	ADJ	JJ	Degree=Pos	_	_	_	_
3	promoter	promoter	NOUN	NN	Number=Sing	_	_	_	_
4	sequences	sequence	NOUN	NNS	Number=Plur	_	_	_	_
5	regulate	regulate	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
6	this	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
7	tissue	tissue	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
8	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
9	specific	specific	ADJ	JJ	Degree=Pos	_	_	_	_
10	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
11	of	of	ADP	IN	_	_	_	_	_
12	class	class	NOUN	NN	Number=Sing	_	_	_	_
13	II	ii	NUM	CD	NumType=Card	_	_	_	_
14	genes	gene	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
15	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 441
# text = In the DRA promoter, one of these cis-acting regulatory motifs is the X2-box to which nuclear factor X2 (NF-X2) binds.
1	In	in	ADP	IN	_	_	_	_	_
2	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
3	DRA	DRa	NOUN	NN	Number=Sing	_	_	_	_
4	promoter	promoter	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
5	,	,	PUNCT	,	_	_	_	_	_
6	one	one	NUM	CD	NumType=Card	_	_	_	_
7	of	of	ADP	IN	_	_	_	_	_
8	these	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
9	cis	cis	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
10	-acting	-act	VERB	VBG	VerbForm=Ger	_	_	_	_
11	regulatory	regulatory	ADJ	JJ	Degree=Pos	_	_	_	_
12	motifs	motif	NOUN	NNS	Number=Plur	_	_	_	_
13	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
14	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
15	X2	x2	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
16	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
17	box	box	NOUN	NN	Number=Sing	_	_	_	_
18	to	to	ADP	IN	_	_	_	_	_
19	which	which	PRON	WDT	PronType=Rel	_	_	_	_
20	nuclear	nuclear	ADJ	JJ	Degree=Pos	_	_	_	_
21	factor	factor	NOUN	NN	Number=Sing	_	_	_	_
22	X2	x2	NUM	CD	NumType=Card	_	_	_	_
23	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
24	NF	Nf	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
25	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
26	X2	x2	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
27	)	)	PUNCT	-RRB-	_	_	_	_	_
28	binds	bind	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
29	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 442
# text = Here, we present the isolation and characterization of the full-length cDNA clone encoding NF-X2.
1	Here	here	ADV	RB	PronType=Dem	_	_	_	SpaceAfter=No
2	,	,	PUNCT	,	_	_	_	_	_
3	we	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
4	present	present	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
5	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
6	isolation	isolation	NOUN	NN	Number=Sing	_	_	_	_
7	and	and	CCONJ	CC	_	_	_	_	_
8	characterization	characterization	NOUN	NN	Number=Sing	_	_	_	_
9	of	of	ADP	IN	_	_	_	_	_
10	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
11	full	full	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
12	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
13	length	length	NOUN	NN	Number=Sing	_	_	_	_
14	cDNA	cDNa	NOUN	NN	Number=Sing	_	_	_	_
15	clone	clone	NOUN	NN	Number=Sing	_	_	_	_
16	encoding	encoding	VERB	VBG	VerbForm=Ger	_	_	_	_
17	NF	Nf	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
18	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
19	X2	x2	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
20	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 443
# text = This cDNA clone was isolated by expression cDNA cloning, and encodes the human c-Jun protein, which together with c-Fos forms the heterodimeric activator protein-1 transcription complex.
1	This	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
2	cDNA	cDNa	NOUN	NN	Number=Sing	_	_	_	_
3	clone	clone	NOUN	NN	Number=Sing	_	_	_	_
4	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
5	isolated	isolate	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
6	by	by	ADP	IN	_	_	_	_	_
7	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
8	cDNA	cDNa	NOUN	NN	Number=Sing	_	_	_	_
9	cloning	cloning	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
10	,	,	PUNCT	,	_	_	_	_	_
11	and	and	CCONJ	CC	_	_	_	_	_
12	encodes	encode	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
13	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
14	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
15	c	c	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
16	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
17	Jun	Jun	PROPN	NNP	Number=Sing	_	_	_	_
18	protein	protein	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
19	,	,	PUNCT	,	_	_	_	_	_
20	which	which	PRON	WDT	PronType=Rel	_	_	_	_
21	together	together	ADV	RB	_	_	_	_	_
22	with	with	ADP	IN	_	_	_	_	_
23	c-	c-	SYM	NFP	_	_	_	_	SpaceAfter=No
24	Fos	Fos	PROPN	NNP	Number=Sing	_	_	_	_
25	forms	form	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
26	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
27	heterodimeric	heterodimeric	ADJ	JJ	Degree=Pos	_	_	_	_
28	activator	activator	NOUN	NN	Number=Sing	_	_	_	_
29	protein	protein	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
30	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
31	1	1	NUM	CD	NumType=Card	_	_	_	_
32	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
33	complex	complex	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
34	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 444
# text = Whereas c-Fos/c-Jun heterodimers do not exist in B cells, they form and bind to the X2-box in class II nonexpressing cells.
1	Whereas	whereas	SCONJ	IN	_	_	_	_	_
2	c-Fos/c	c-Fos/c	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
3	-Jun	-Jun	PROPN	NNP	Number=Sing	_	_	_	_
4	heterodimers	heterodimer	NOUN	NNS	Number=Plur	_	_	_	_
5	do	do	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
6	not	not	PART	RB	_	_	_	_	_
7	exist	exist	VERB	VB	VerbForm=Inf	_	_	_	_
8	in	in	ADP	IN	_	_	_	_	_
9	B	b	ADJ	JJ	Degree=Pos	_	_	_	_
10	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
11	,	,	PUNCT	,	_	_	_	_	_
12	they	they	PRON	PRP	Case=Nom|Number=Plur|Person=3|PronType=Prs	_	_	_	_
13	form	form	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
14	and	and	CCONJ	CC	_	_	_	_	_
15	bind	bind	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
16	to	to	ADP	IN	_	_	_	_	_
17	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
18	X2	X2	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
19	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
20	box	box	NOUN	NN	Number=Sing	_	_	_	_
21	in	in	ADP	IN	_	_	_	_	_
22	class	class	NOUN	NN	Number=Sing	_	_	_	_
23	II	ii	NUM	CD	NumType=Card	_	_	_	_
24	nonexpressing	nonexpresse	ADJ	JJ	Degree=Pos	_	_	_	_
25	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
26	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 445
# text = Thus, c-Fos/c-Jun heterodimers might contribute to the repression of DRA gene expression.
1	Thus	thus	ADV	RB	_	_	_	_	SpaceAfter=No
2	,	,	PUNCT	,	_	_	_	_	_
3	c-Fos/c	c-Fos/c	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
4	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
5	Jun	Jun	PROPN	NNP	Number=Sing	_	_	_	_
6	heterodimers	heterodimer	NOUN	NNS	Number=Plur	_	_	_	_
7	might	might	AUX	MD	VerbForm=Fin	_	_	_	_
8	contribute	contribute	VERB	VB	VerbForm=Inf	_	_	_	_
9	to	to	ADP	IN	_	_	_	_	_
10	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
11	repression	repression	NOUN	NN	Number=Sing	_	_	_	_
12	of	of	ADP	IN	_	_	_	_	_
13	DRA	DRA	NOUN	NN	Number=Sing	_	_	_	_
14	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
15	expression	expression	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
16	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 446
# text = Document 003002158 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	003002158	003002158	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 447
# text = The lymphotoxin promoter is stimulated by HTLV-I tax activation of NF-kappa B in human T-cell lines.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	lymphotoxin	lymphotoxin	NOUN	NN	Number=Sing	_	_	_	_
3	promoter	promoter	NOUN	NN	Number=Sing	_	_	_	_
4	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
5	stimulated	stimulate	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
6	by	by	ADP	IN	_	_	_	_	_
7	HTLV	HTLV	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
8	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
9	I	I	PRON	PRP	Case=Nom|Number=Sing|Person=1|PronType=Prs	_	_	_	_
10	tax	tax	NOUN	NN	Number=Sing	_	_	_	_
11	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
12	of	of	ADP	IN	_	_	_	_	_
13	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
14	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
15	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_
16	B	b	NOUN	NN	Number=Sing	_	_	_	_
17	in	in	ADP	IN	_	_	_	_	_
18	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
19	T-	t-	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
20	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
21	lines	line	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
22	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 448
# text = The HTLV-I transcriptional activator tax was used to gain insight into the mechanism of lymphotoxin (LT; TNF-beta) gene induction.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	HTLV	Htlv	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
3	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
4	I	I	PRON	PRP	Case=Nom|Number=Sing|Person=1|PronType=Prs	_	_	_	_
5	transcriptional	transcriptional	ADJ	JJ	Degree=Pos	_	_	_	_
6	activator	activator	NOUN	NN	Number=Sing	_	_	_	_
7	tax	tax	NOUN	NN	Number=Sing	_	_	_	_
8	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
9	used	use	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
10	to	to	PART	TO	_	_	_	_	_
11	gain	gain	VERB	VB	VerbForm=Inf	_	_	_	_
12	insight	insight	NOUN	NN	Number=Sing	_	_	_	_
13	into	into	ADP	IN	_	_	_	_	_
14	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
15	mechanism	mechanism	NOUN	NN	Number=Sing	_	_	_	_
16	of	of	ADP	IN	_	_	_	_	_
17	lymphotoxin	lymphotoxin	NOUN	NN	Number=Sing	_	_	_	_
18	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
19	LT	Lt	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
20	;	;	PUNCT	,	_	_	_	_	_
21	TNF	Tnf	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
22	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
23	beta	beta	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
24	)	)	PUNCT	-RRB-	_	_	_	_	_
25	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
26	induction	induction	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
27	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 449
# text = Tax-expressing cell lines produce LT biologic activity.
1	Tax	tax	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
2	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
3	expressing	express	VERB	VBG	VerbForm=Ger	_	_	_	_
4	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
5	lines	line	NOUN	NNS	Number=Plur	_	_	_	_
6	produce	produce	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
7	LT	Lt	ADJ	JJ	Degree=Pos	_	_	_	_
8	biologic	biologic	ADJ	JJ	Degree=Pos	_	_	_	_
9	activity	activity	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
10	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 450
# text = An LT promoter (LT-293)
1	An	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
2	LT	Lt	ADJ	JJS	Degree=Sup	_	_	_	_
3	promoter	promoter	NOUN	NN	Number=Sing	_	_	_	_
4	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
5	LT	LT	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
6	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
7	293	293	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
8	)	)	PUNCT	-RRB-	_	_	_	_	_

# sent_id = 451
# text = CAT construct that contained an NF-kappa B site was active in the LT-producing C81-66-45 cell line, which contains defective HTLV-I but expresses tax.
1	CAT	cat	ADJ	JJ	Degree=Pos	_	_	_	_
2	construct	construct	NOUN	NN	Number=Sing	_	_	_	_
3	that	that	PRON	WDT	PronType=Rel	_	_	_	_
4	contained	contain	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
5	an	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
6	NF	NF	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
7	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
8	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_
9	B	b	NOUN	NN	Number=Sing	_	_	_	_
10	site	site	NOUN	NN	Number=Sing	_	_	_	_
11	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
12	active	active	ADJ	JJ	Degree=Pos	_	_	_	_
13	in	in	ADP	IN	_	_	_	_	_
14	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
15	LT-	Lt-	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
16	producing	produce	VERB	VBG	VerbForm=Ger	_	_	_	_
17	C81-66	C81-66	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
18	-	-	SYM	SYM	_	_	_	_	SpaceAfter=No
19	45	45	NUM	CD	NumType=Card	_	_	_	_
20	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
21	line	line	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
22	,	,	PUNCT	,	_	_	_	_	_
23	which	which	PRON	WDT	PronType=Rel	_	_	_	_
24	contains	contain	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
25	defective	defective	ADJ	JJ	Degree=Pos	_	_	_	_
26	HTLV	Htlv	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
27	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
28	I	I	PRON	PRP	Case=Nom|Number=Sing|Person=1|PronType=Prs	_	_	_	_
29	but	but	CCONJ	CC	_	_	_	_	_
30	expresses	expresse	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
31	tax	tax	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
32	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 452
# text = The observation that a mutated LT-kappa B construct (M1-CAT) was inactive in C81-66-45, confirmed the importance of NF-kappa B in LT gene expression.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	observation	observation	NOUN	NN	Number=Sing	_	_	_	_
3	that	that	PRON	WDT	PronType=Rel	_	_	_	_
4	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
5	mutated	mutate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
6	LT	Lt	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
7	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
8	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_
9	B	b	NOUN	NN	Number=Sing	_	_	_	_
10	construct	construct	NOUN	NN	Number=Sing	_	_	_	_
11	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
12	M1	m1	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
13	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
14	CAT	cat	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
15	)	)	PUNCT	-RRB-	_	_	_	_	_
16	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
17	inactive	inactive	ADJ	JJ	Degree=Pos	_	_	_	_
18	in	in	ADP	IN	_	_	_	_	_
19	C81-66	C81-66	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
20	-45	-45	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
21	,	,	PUNCT	,	_	_	_	_	_
22	confirmed	confirm	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
23	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
24	importance	importance	NOUN	NN	Number=Sing	_	_	_	_
25	of	of	ADP	IN	_	_	_	_	_
26	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
27	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
28	kappa	kappa	PROPN	NNP	Number=Sing	_	_	_	_
29	B	b	PROPN	NNP	Number=Sing	_	_	_	_
30	in	in	ADP	IN	_	_	_	_	_
31	LT	LT	PROPN	NNP	Number=Sing	_	_	_	_
32	gene	gene	PROPN	NNP	Number=Sing	_	_	_	_
33	expression	expression	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
34	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 453
# text = Tax was transfected into HTLV-I-negative human T-cell lines.
1	Tax	tax	NOUN	NN	Number=Sing	_	_	_	_
2	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
3	transfected	transfect	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
4	into	into	ADP	IN	_	_	_	_	_
5	HTLV	HTLV	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
6	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
7	I	I	PRON	PRP	Case=Nom|Number=Sing|Person=1|PronType=Prs	_	_	_	SpaceAfter=No
8	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
9	negative	negative	ADJ	JJ	Degree=Pos	_	_	_	_
10	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
11	T-	T-	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
12	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
13	lines	line	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
14	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 454
# text = Jurkat
1	Jurkat	Jurkat	PROPN	NNP	Number=Sing	_	_	_	_

# sent_id = 455
# text = T cells stably expressing tax contained elevated levels of NF-kappa B that directly bound to the LT-kappa B site.
1	T	t	NUM	CD	NumType=Card	_	_	_	_
2	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
3	stably	stably	ADV	RB	_	_	_	_	_
4	expressing	express	VERB	VBG	VerbForm=Ger	_	_	_	_
5	tax	tax	NOUN	NN	Number=Sing	_	_	_	_
6	contained	contain	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
7	elevated	elevate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
8	levels	level	NOUN	NNS	Number=Plur	_	_	_	_
9	of	of	ADP	IN	_	_	_	_	_
10	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
11	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
12	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_
13	B	b	NOUN	NN	Number=Sing	_	_	_	_
14	that	that	PRON	WDT	PronType=Rel	_	_	_	_
15	directly	directly	ADV	RB	_	_	_	_	_
16	bound	bound	ADJ	JJ	Degree=Pos	_	_	_	_
17	to	to	ADP	IN	_	_	_	_	_
18	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
19	LT	Lt	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
20	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
21	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_
22	B	b	NOUN	NN	Number=Sing	_	_	_	_
23	site	site	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
24	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 456
# text = Tax co-transfected with reporter constructs into Jurkat cells maximally activated HTLV-I-LTR-CAT and kappa B-fos-CAT and also activated LT-293 to a lesser extent.
1	Tax	tax	NOUN	NN	Number=Sing	_	_	_	_
2	co-transfected	co-transfect	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
3	with	with	ADP	IN	_	_	_	_	_
4	reporter	reporter	NOUN	NN	Number=Sing	_	_	_	_
5	constructs	constructs	NOUN	NNS	Number=Plur	_	_	_	_
6	into	into	ADP	IN	_	_	_	_	_
7	Jurkat	Jurkat	PROPN	NNP	Number=Sing	_	_	_	_
8	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
9	maximally	maximally	ADV	RB	_	_	_	_	_
10	activated	activate	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
11	HTLV	HTLV	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
12	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
13	I	I	PRON	PRP	Case=Nom|Number=Sing|Person=1|PronType=Prs	_	_	_	SpaceAfter=No
14	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
15	LTR-	LTR-	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
16	CAT	cat	NOUN	NN	Number=Sing	_	_	_	_
17	and	and	CCONJ	CC	_	_	_	_	_
18	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_
19	B	b	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
20	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
21	fos	fos	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
22	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
23	CAT	Cat	NOUN	NN	Number=Sing	_	_	_	_
24	and	and	CCONJ	CC	_	_	_	_	_
25	also	also	ADV	RB	_	_	_	_	_
26	activated	activate	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
27	LT	LT	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
28	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
29	293	293	NUM	CD	NumType=Card	_	_	_	_
30	to	to	ADP	IN	_	_	_	_	_
31	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
32	lesser	lesser	ADJ	JJR	Degree=Cmp	_	_	_	_
33	extent	extent	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
34	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 457
# text = In JM T cells, tax induced LT-293 activity by two- to four-fold, though there was no induction of M1-CAT.
1	In	in	ADP	IN	_	_	_	_	_
2	JM	JM	PROPN	NNP	Number=Sing	_	_	_	_
3	T	t	PROPN	NNP	Number=Sing	_	_	_	_
4	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
5	,	,	PUNCT	,	_	_	_	_	_
6	tax	tax	NOUN	NN	Number=Sing	_	_	_	_
7	induced	induce	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
8	LT	LT	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
9	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
10	293	293	NUM	CD	NumType=Card	_	_	_	_
11	activity	activity	NOUN	NN	Number=Sing	_	_	_	_
12	by	by	ADP	IN	_	_	_	_	_
13	two	two	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
14	-	-	SYM	SYM	_	_	_	_	_
15	to	to	ADP	IN	_	_	_	_	_
16	four	four	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
17	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
18	fold	fold	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
19	,	,	PUNCT	,	_	_	_	_	_
20	though	though	SCONJ	IN	_	_	_	_	_
21	there	there	PRON	EX	_	_	_	_	_
22	was	be	VERB	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
23	no	no	DET	DT	_	_	_	_	_
24	induction	induction	NOUN	NN	Number=Sing	_	_	_	_
25	of	of	ADP	IN	_	_	_	_	_
26	M1	M1	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
27	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
28	CAT	cat	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
29	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 458
# text = The increase in LT-293 CAT activity mirrored the increase in LT biologic activity seen under these conditions.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	increase	increase	NOUN	NN	Number=Sing	_	_	_	_
3	in	in	ADP	IN	_	_	_	_	_
4	LT	LT	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
5	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
6	293	293	NUM	CD	NumType=Card	_	_	_	_
7	CAT	cat	NOUN	NN	Number=Sing	_	_	_	_
8	activity	activity	NOUN	NN	Number=Sing	_	_	_	_
9	mirrored	mirror	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
10	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
11	increase	increase	NOUN	NN	Number=Sing	_	_	_	_
12	in	in	ADP	IN	_	_	_	_	_
13	LT	LT	PROPN	NNP	Number=Sing	_	_	_	_
14	biologic	biologic	ADJ	JJ	Degree=Pos	_	_	_	_
15	activity	activity	NOUN	NN	Number=Sing	_	_	_	_
16	seen	see	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
17	under	under	ADP	IN	_	_	_	_	_
18	these	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
19	conditions	condition	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
20	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 459
# text = These studies, the first to demonstrate induction of LT promoter activity over basal levels, indicate that HTLV-I tax causes low-level activation of both endogenous LT and the LT promoter, at least in part through activation of NF-kappa B.
1	These	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
2	studies	study	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
3	,	,	PUNCT	,	_	_	_	_	_
4	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
5	first	first	ADJ	JJ	Degree=Pos|NumType=Ord	_	_	_	_
6	to	to	PART	TO	_	_	_	_	_
7	demonstrate	demonstrate	VERB	VB	VerbForm=Inf	_	_	_	_
8	induction	induction	NOUN	NN	Number=Sing	_	_	_	_
9	of	of	ADP	IN	_	_	_	_	_
10	LT	Lt	ADJ	JJ	Degree=Pos	_	_	_	_
11	promoter	promoter	NOUN	NN	Number=Sing	_	_	_	_
12	activity	activity	NOUN	NN	Number=Sing	_	_	_	_
13	over	over	ADP	IN	_	_	_	_	_
14	basal	basal	ADJ	JJ	Degree=Pos	_	_	_	_
15	levels	level	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
16	,	,	PUNCT	,	_	_	_	_	_
17	indicate	indicate	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
18	that	that	SCONJ	IN	_	_	_	_	_
19	HTLV	HTLV	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
20	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
21	I	I	PRON	PRP	Case=Nom|Number=Sing|Person=1|PronType=Prs	_	_	_	_
22	tax	tax	NOUN	NN	Number=Sing	_	_	_	_
23	causes	cause	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
24	low	low	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
25	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
26	level	level	NOUN	NN	Number=Sing	_	_	_	_
27	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
28	of	of	ADP	IN	_	_	_	_	_
29	both	both	DET	DT	_	_	_	_	_
30	endogenous	endogenous	ADJ	JJ	Degree=Pos	_	_	_	_
31	LT	Lt	NOUN	NN	Number=Sing	_	_	_	_
32	and	and	CCONJ	CC	_	_	_	_	_
33	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
34	LT	Lt	ADJ	JJ	Degree=Pos	_	_	_	_
35	promoter	promoter	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
36	,	,	PUNCT	,	_	_	_	_	_
37	at	at	ADV	RB	_	_	_	_	_
38	least	least	ADV	RBS	Degree=Sup	_	_	_	_
39	in	in	ADP	IN	_	_	_	_	_
40	part	part	NOUN	NN	Number=Sing	_	_	_	_
41	through	through	ADP	IN	_	_	_	_	_
42	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
43	of	of	ADP	IN	_	_	_	_	_
44	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
45	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
46	kappa	kappa	PROPN	NNP	Number=Sing	_	_	_	_
47	B.	B.	PROPN	NNP	Number=Sing	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 460
# text = Document 003002162 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	003002162	003002162	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 461
# text = Triggering of HLA-DR antigens differentially modulates tumor necrosis factor alpha release by B cells at distinct stage of maturation.
1	Triggering	Triggering	ADP	IN	_	_	_	_	_
2	of	of	ADP	IN	_	_	_	_	_
3	HLA	HLA	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
4	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
5	DR	dr	PROPN	NNP	Number=Sing	_	_	_	_
6	antigens	antigen	NOUN	NNS	Number=Plur	_	_	_	_
7	differentially	differentially	ADV	RB	_	_	_	_	_
8	modulates	modulate	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
9	tumor	tumor	NOUN	NN	Number=Sing	_	_	_	_
10	necrosis	necrosis	NOUN	NN	Number=Sing	_	_	_	_
11	factor	factor	NOUN	NN	Number=Sing	_	_	_	_
12	alpha	alpha	NOUN	NN	Number=Sing	_	_	_	_
13	release	release	NOUN	NN	Number=Sing	_	_	_	_
14	by	by	ADP	IN	_	_	_	_	_
15	B	b	ADJ	JJ	Degree=Pos	_	_	_	_
16	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
17	at	at	ADP	IN	_	_	_	_	_
18	distinct	distinct	ADJ	JJ	Degree=Pos	_	_	_	_
19	stage	stage	NOUN	NN	Number=Sing	_	_	_	_
20	of	of	ADP	IN	_	_	_	_	_
21	maturation	maturation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
22	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 462
# text = Triggering of HLA class II antigens by the anti-HLA-DR monoclonal antibody (mAb) L243 significantly (P < 0.05) and differentially enhanced the release of tumor necrosis factor alpha (TNF-alpha) by the non-Hodgkin's lymphoma cells Ri-I, Ci-I, and Sc-I, which are at a distinct stage of B-cell differentiation, and by the more mature Burkitt lymphoma cell Raji; in contrast, it did not induce TNF-alpha release by the pre-B leukemia cells Nalm-6 and BV173.
1	Triggering	Triggering	ADP	IN	_	_	_	_	_
2	of	of	ADP	IN	_	_	_	_	_
3	HLA	HLA	PROPN	NNP	Number=Sing	_	_	_	_
4	class	class	NOUN	NN	Number=Sing	_	_	_	_
5	II	ii	NUM	CD	NumType=Card	_	_	_	_
6	antigens	antigen	NOUN	NNS	Number=Plur	_	_	_	_
7	by	by	ADP	IN	_	_	_	_	_
8	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
9	anti-HLA	anti-hla	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
10	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
11	DR	Dr	ADJ	JJ	Degree=Pos	_	_	_	_
12	monoclonal	monoclonal	ADJ	JJ	Degree=Pos	_	_	_	_
13	antibody	antibody	NOUN	NN	Number=Sing	_	_	_	_
14	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
15	mAb	mAb	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
16	)	)	PUNCT	-RRB-	_	_	_	_	_
17	L243	L243	NOUN	NN	Number=Sing	_	_	_	_
18	significantly	significantly	ADV	RB	_	_	_	_	_
19	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
20	P	p	NOUN	NN	Number=Sing	_	_	_	_
21	<	<	PUNCT	-LRB-	_	_	_	_	_
22	0.05	0.05	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
23	)	)	PUNCT	-RRB-	_	_	_	_	_
24	and	and	CCONJ	CC	_	_	_	_	_
25	differentially	differentially	ADV	RB	_	_	_	_	_
26	enhanced	enhance	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
27	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
28	release	release	NOUN	NN	Number=Sing	_	_	_	_
29	of	of	ADP	IN	_	_	_	_	_
30	tumor	tumor	NOUN	NN	Number=Sing	_	_	_	_
31	necrosis	necrosis	NOUN	NN	Number=Sing	_	_	_	_
32	factor	factor	NOUN	NN	Number=Sing	_	_	_	_
33	alpha	alpha	NOUN	NN	Number=Sing	_	_	_	_
34	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
35	TNF	Tnf	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
36	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
37	alpha	alpha	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
38	)	)	PUNCT	-RRB-	_	_	_	_	_
39	by	by	ADP	IN	_	_	_	_	_
40	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
41	non-Hodgkin	non-hodgkin	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
42	's	's	PART	POS	_	_	_	_	_
43	lymphoma	lymphoma	NOUN	NN	Number=Sing	_	_	_	_
44	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
45	Ri	ri	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
46	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
47	I	I	PRON	PRP	Case=Nom|Number=Sing|Person=1|PronType=Prs	_	_	_	SpaceAfter=No
48	,	,	PUNCT	,	_	_	_	_	_
49	Ci	Ci	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
50	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
51	I	I	PRON	PRP	Case=Nom|Number=Sing|Person=1|PronType=Prs	_	_	_	SpaceAfter=No
52	,	,	PUNCT	,	_	_	_	_	_
53	and	and	CCONJ	CC	_	_	_	_	_
54	Sc	Sc	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
55	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
56	I	I	PRON	PRP	Case=Nom|Number=Sing|Person=1|PronType=Prs	_	_	_	SpaceAfter=No
57	,	,	PUNCT	,	_	_	_	_	_
58	which	which	PRON	WDT	PronType=Rel	_	_	_	_
59	are	be	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
60	at	at	ADP	IN	_	_	_	_	_
61	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
62	distinct	distinct	ADJ	JJ	Degree=Pos	_	_	_	_
63	stage	stage	NOUN	NN	Number=Sing	_	_	_	_
64	of	of	ADP	IN	_	_	_	_	_
65	B	b	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
66	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
67	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
68	differentiation	differentiation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
69	,	,	PUNCT	,	_	_	_	_	_
70	and	and	CCONJ	CC	_	_	_	_	_
71	by	by	ADP	IN	_	_	_	_	_
72	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
73	more	more	ADV	RBR	_	_	_	_	_
74	mature	mature	ADJ	JJ	Degree=Pos	_	_	_	_
75	Burkitt	Burkitt	PROPN	NNP	Number=Sing	_	_	_	_
76	lymphoma	lymphoma	NOUN	NN	Number=Sing	_	_	_	_
77	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
78	Raji	Raji	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
79	;	;	PUNCT	,	_	_	_	_	_
80	in	in	ADP	IN	_	_	_	_	_
81	contrast	contrast	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
82	,	,	PUNCT	,	_	_	_	_	_
83	it	it	PRON	PRP	Case=Nom|Gender=Neut|Number=Sing|Person=3|PronType=Prs	_	_	_	_
84	did	do	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
85	not	not	PART	RB	_	_	_	_	_
86	induce	induce	VERB	VB	VerbForm=Inf	_	_	_	_
87	TNF	Tnf	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
88	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
89	alpha	alpha	NOUN	NN	Number=Sing	_	_	_	_
90	release	release	NOUN	NN	Number=Sing	_	_	_	_
91	by	by	ADP	IN	_	_	_	_	_
92	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
93	pre	pre	X	AFX	_	_	_	_	SpaceAfter=No
94	-B	-b	ADJ	JJ	Degree=Pos	_	_	_	_
95	leukemia	leukemia	NOUN	NN	Number=Sing	_	_	_	_
96	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
97	Nalm	Nalm	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
98	-	-	SYM	SYM	_	_	_	_	SpaceAfter=No
99	6	6	NUM	CD	NumType=Card	_	_	_	_
100	and	and	CCONJ	CC	_	_	_	_	_
101	BV	BV	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
102	173	173	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
103	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 463
# text = TNF-alpha release peaked at 24 h and decreased thereafter, and it was dose dependent and preceded by an increase of TNF-alpha mRNA detectable after 3 h of stimulation with mAb L243.
1	TNF	Tnf	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
2	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
3	alpha	alpha	NOUN	NN	Number=Sing	_	_	_	_
4	release	release	NOUN	NN	Number=Sing	_	_	_	_
5	peaked	peake	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
6	at	at	ADP	IN	_	_	_	_	_
7	24	24	NUM	CD	NumType=Card	_	_	_	_
8	h	h	NOUN	NN	Number=Sing	_	_	_	_
9	and	and	CCONJ	CC	_	_	_	_	_
10	decreased	decrease	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
11	thereafter	thereafter	ADV	RB	_	_	_	_	SpaceAfter=No
12	,	,	PUNCT	,	_	_	_	_	_
13	and	and	CCONJ	CC	_	_	_	_	_
14	it	it	PRON	PRP	Case=Nom|Gender=Neut|Number=Sing|Person=3|PronType=Prs	_	_	_	_
15	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
16	dose	dose	VERB	VB	VerbForm=Inf	_	_	_	_
17	dependent	dependent	ADJ	JJ	Degree=Pos	_	_	_	_
18	and	and	CCONJ	CC	_	_	_	_	_
19	preceded	preced	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
20	by	by	ADP	IN	_	_	_	_	_
21	an	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
22	increase	increase	NOUN	NN	Number=Sing	_	_	_	_
23	of	of	ADP	IN	_	_	_	_	_
24	TNF	TNF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
25	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
26	alpha	alpha	PROPN	NNP	Number=Sing	_	_	_	_
27	mRNA	mRNA	PROPN	NNP	Number=Sing	_	_	_	_
28	detectable	detectable	ADJ	JJ	Degree=Pos	_	_	_	_
29	after	after	ADP	IN	_	_	_	_	_
30	3	3	NUM	CD	NumType=Card	_	_	_	_
31	h	h	NOUN	NN	Number=Sing	_	_	_	_
32	of	of	ADP	IN	_	_	_	_	_
33	stimulation	stimulation	NOUN	NN	Number=Sing	_	_	_	_
34	with	with	ADP	IN	_	_	_	_	_
35	mAb	mAb	PROPN	NNP	Number=Sing	_	_	_	_
36	L243	L243	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
37	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 464
# text = Secreted TNF-alpha mediated the enhancement of nuclear factor kappa B (NF-kappa B) and activator protein-1 (AP-1) binding activity; in fact, the triggering of HLA-DR antigens in the presence of antihuman TNF-alpha-neutralizing antibodies did not upregulate NF-kappa B and AP-1.
1	Secreted	Secret	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
2	TNF	TNF	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
3	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
4	alpha	alpha	NOUN	NN	Number=Sing	_	_	_	_
5	mediated	mediate	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
6	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
7	enhancement	enhancement	NOUN	NN	Number=Sing	_	_	_	_
8	of	of	ADP	IN	_	_	_	_	_
9	nuclear	nuclear	ADJ	JJ	Degree=Pos	_	_	_	_
10	factor	factor	NOUN	NN	Number=Sing	_	_	_	_
11	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_
12	B	b	NOUN	NN	Number=Sing	_	_	_	_
13	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
14	NF	Nf	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
15	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
16	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_
17	B	b	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
18	)	)	PUNCT	-RRB-	_	_	_	_	_
19	and	and	CCONJ	CC	_	_	_	_	_
20	activator	activator	NOUN	NN	Number=Sing	_	_	_	_
21	protein	protein	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
22	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
23	1	1	NUM	CD	NumType=Card	_	_	_	_
24	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
25	AP	ap	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
26	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
27	1	1	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
28	)	)	PUNCT	-RRB-	_	_	_	_	_
29	binding	bind	VERB	VBG	VerbForm=Ger	_	_	_	_
30	activity	activity	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
31	;	;	PUNCT	,	_	_	_	_	_
32	in	in	ADP	IN	_	_	_	_	_
33	fact	fact	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
34	,	,	PUNCT	,	_	_	_	_	_
35	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
36	triggering	triggering	NOUN	NN	Number=Sing	_	_	_	_
37	of	of	ADP	IN	_	_	_	_	_
38	HLA	HLA	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
39	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
40	DR	dr	PROPN	NNP	Number=Sing	_	_	_	_
41	antigens	antigen	NOUN	NNS	Number=Plur	_	_	_	_
42	in	in	ADP	IN	_	_	_	_	_
43	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
44	presence	presence	NOUN	NN	Number=Sing	_	_	_	_
45	of	of	ADP	IN	_	_	_	_	_
46	antihuman	antihuman	ADJ	JJ	Degree=Pos	_	_	_	_
47	TNF	Tnf	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
48	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
49	alpha	alpha	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
50	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
51	neutralizing	neutralizing	VERB	VBG	VerbForm=Ger	_	_	_	_
52	antibodies	antibody	NOUN	NNS	Number=Plur	_	_	_	_
53	did	do	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
54	not	not	PART	RB	_	_	_	_	_
55	upregulate	upregulate	VERB	VB	VerbForm=Inf	_	_	_	_
56	NF	Nf	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
57	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
58	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_
59	B	b	NOUN	NN	Number=Sing	_	_	_	_
60	and	and	CCONJ	CC	_	_	_	_	_
61	AP	ap	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
62	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
63	1	1	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
64	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 465
# text = In contrast, released TNF-alpha was not responsible for the homotypic aggregation of Ri-I, Ci-I, Sc-I, and Raji cells induced by mAb L243, and it did not affect the proliferation of B cells investigated.
1	In	in	ADP	IN	_	_	_	_	_
2	contrast	contrast	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
3	,	,	PUNCT	,	_	_	_	_	_
4	released	release	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
5	TNF	TNF	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
6	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
7	alpha	alpha	NOUN	NN	Number=Sing	_	_	_	_
8	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
9	not	not	PART	RB	_	_	_	_	_
10	responsible	responsible	ADJ	JJ	Degree=Pos	_	_	_	_
11	for	for	ADP	IN	_	_	_	_	_
12	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
13	homotypic	homotypic	ADJ	JJ	Degree=Pos	_	_	_	_
14	aggregation	aggregation	NOUN	NN	Number=Sing	_	_	_	_
15	of	of	ADP	IN	_	_	_	_	_
16	Ri	ri	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
17	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
18	I	I	PRON	PRP	Case=Nom|Number=Sing|Person=1|PronType=Prs	_	_	_	SpaceAfter=No
19	,	,	PUNCT	,	_	_	_	_	_
20	Ci	Ci	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
21	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
22	I	I	PRON	PRP	Case=Nom|Number=Sing|Person=1|PronType=Prs	_	_	_	SpaceAfter=No
23	,	,	PUNCT	,	_	_	_	_	_
24	Sc	Sc	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
25	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
26	I	I	PRON	PRP	Case=Nom|Number=Sing|Person=1|PronType=Prs	_	_	_	SpaceAfter=No
27	,	,	PUNCT	,	_	_	_	_	_
28	and	and	CCONJ	CC	_	_	_	_	_
29	Raji	Raji	PROPN	NNP	Number=Sing	_	_	_	_
30	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
31	induced	induce	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
32	by	by	ADP	IN	_	_	_	_	_
33	mAb	mAb	PROPN	NNP	Number=Sing	_	_	_	_
34	L243	L243	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
35	,	,	PUNCT	,	_	_	_	_	_
36	and	and	CCONJ	CC	_	_	_	_	_
37	it	it	PRON	PRP	Case=Nom|Gender=Neut|Number=Sing|Person=3|PronType=Prs	_	_	_	_
38	did	do	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
39	not	not	PART	RB	_	_	_	_	_
40	affect	affect	VERB	VB	VerbForm=Inf	_	_	_	_
41	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
42	proliferation	proliferation	NOUN	NN	Number=Sing	_	_	_	_
43	of	of	ADP	IN	_	_	_	_	_
44	B	b	ADJ	JJ	Degree=Pos	_	_	_	_
45	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
46	investigated	investigate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	SpaceAfter=No
47	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 466
# text = Altogether, our data demonstrate that: (a) the ability of B cells to release TNF-alpha after triggering of HLA-DR antigens depends on their stage of differentiation; (b) levels of released TNF-alpha seem to correlate with the stage of B-cell maturation but do not correlate with the amounts of cell surface HLA-DR antigens; (c) secreted TNF-alpha regulates the levels of expression of NF-kappa B and AP-1 by an autocrine loop; and (d) intracellular signals mediating TNF-alpha release by B cells are distinct from those regulating homotypic aggregation and proliferation.
1	Altogether	altogether	ADV	RB	_	_	_	_	SpaceAfter=No
2	,	,	PUNCT	,	_	_	_	_	_
3	our	we	PRON	PRP$	Number=Plur|Person=1|Poss=Yes|PronType=Prs	_	_	_	_
4	data	data	NOUN	NN	Number=Sing	_	_	_	_
5	demonstrate	demonstrate	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
6	that	that	PRON	DT	Number=Sing|PronType=Dem	_	_	_	SpaceAfter=No
7	:	:	PUNCT	:	_	_	_	_	_
8	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
9	a	a	X	LS	_	_	_	_	SpaceAfter=No
10	)	)	PUNCT	-RRB-	_	_	_	_	_
11	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
12	ability	ability	NOUN	NN	Number=Sing	_	_	_	_
13	of	of	ADP	IN	_	_	_	_	_
14	B	b	ADJ	JJ	Degree=Pos	_	_	_	_
15	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
16	to	to	PART	TO	_	_	_	_	_
17	release	release	VERB	VB	VerbForm=Inf	_	_	_	_
18	TNF	Tnf	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
19	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
20	alpha	alpha	NOUN	NN	Number=Sing	_	_	_	_
21	after	after	SCONJ	IN	_	_	_	_	_
22	triggering	triggere	VERB	VBG	VerbForm=Ger	_	_	_	_
23	of	of	ADP	IN	_	_	_	_	_
24	HLA	HLA	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
25	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
26	DR	dr	PROPN	NNP	Number=Sing	_	_	_	_
27	antigens	antigen	NOUN	NNS	Number=Plur	_	_	_	_
28	depends	depend	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
29	on	on	ADP	IN	_	_	_	_	_
30	their	they	PRON	PRP$	Number=Plur|Person=3|Poss=Yes|PronType=Prs	_	_	_	_
31	stage	stage	NOUN	NN	Number=Sing	_	_	_	_
32	of	of	ADP	IN	_	_	_	_	_
33	differentiation	differentiation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
34	;	;	PUNCT	,	_	_	_	_	_
35	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
36	b	b	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
37	)	)	PUNCT	-RRB-	_	_	_	_	_
38	levels	level	NOUN	NNS	Number=Plur	_	_	_	_
39	of	of	ADP	IN	_	_	_	_	_
40	released	release	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
41	TNF	TNF	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
42	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
43	alpha	alpha	NOUN	NN	Number=Sing	_	_	_	_
44	seem	seem	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
45	to	to	PART	TO	_	_	_	_	_
46	correlate	correlate	VERB	VB	VerbForm=Inf	_	_	_	_
47	with	with	ADP	IN	_	_	_	_	_
48	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
49	stage	stage	NOUN	NN	Number=Sing	_	_	_	_
50	of	of	ADP	IN	_	_	_	_	_
51	B	b	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
52	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
53	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
54	maturation	maturation	NOUN	NN	Number=Sing	_	_	_	_
55	but	but	CCONJ	CC	_	_	_	_	_
56	do	do	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
57	not	not	PART	RB	_	_	_	_	_
58	correlate	correlate	VERB	VB	VerbForm=Inf	_	_	_	_
59	with	with	ADP	IN	_	_	_	_	_
60	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
61	amounts	amount	NOUN	NNS	Number=Plur	_	_	_	_
62	of	of	ADP	IN	_	_	_	_	_
63	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
64	surface	surface	NOUN	NN	Number=Sing	_	_	_	_
65	HLA	HLa	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
66	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
67	DR	dr	NOUN	NN	Number=Sing	_	_	_	_
68	antigens	antigen	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
69	;	;	PUNCT	,	_	_	_	_	_
70	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
71	c	c	X	LS	_	_	_	_	SpaceAfter=No
72	)	)	PUNCT	-RRB-	_	_	_	_	_
73	secreted	secret	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
74	TNF	TNF	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
75	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
76	alpha	alpha	NOUN	NN	Number=Sing	_	_	_	_
77	regulates	regulate	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
78	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
79	levels	level	NOUN	NNS	Number=Plur	_	_	_	_
80	of	of	ADP	IN	_	_	_	_	_
81	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
82	of	of	ADP	IN	_	_	_	_	_
83	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
84	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
85	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_
86	B	b	NOUN	NN	Number=Sing	_	_	_	_
87	and	and	CCONJ	CC	_	_	_	_	_
88	AP	ap	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
89	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
90	1	1	NUM	CD	NumType=Card	_	_	_	_
91	by	by	ADP	IN	_	_	_	_	_
92	an	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
93	autocrine	autocrine	ADJ	JJ	Degree=Pos	_	_	_	_
94	loop	loop	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
95	;	;	PUNCT	,	_	_	_	_	_
96	and	and	CCONJ	CC	_	_	_	_	_
97	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
98	d	would	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
99	)	)	PUNCT	-RRB-	_	_	_	_	_
100	intracellular	intracellular	ADJ	JJ	Degree=Pos	_	_	_	_
101	signals	signal	NOUN	NNS	Number=Plur	_	_	_	_
102	mediating	mediat	VERB	VBG	VerbForm=Ger	_	_	_	_
103	TNF	Tnf	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
104	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
105	alpha	alpha	NOUN	NN	Number=Sing	_	_	_	_
106	release	release	NOUN	NN	Number=Sing	_	_	_	_
107	by	by	ADP	IN	_	_	_	_	_
108	B	b	ADJ	JJ	Degree=Pos	_	_	_	_
109	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
110	are	be	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
111	distinct	distinct	ADJ	JJ	Degree=Pos	_	_	_	_
112	from	from	ADP	IN	_	_	_	_	_
113	those	those	PRON	DT	Number=Plur|PronType=Dem	_	_	_	_
114	regulating	regulate	VERB	VBG	VerbForm=Ger	_	_	_	_
115	homotypic	homotypic	ADJ	JJ	Degree=Pos	_	_	_	_
116	aggregation	aggregation	NOUN	NN	Number=Sing	_	_	_	_
117	and	and	CCONJ	CC	_	_	_	_	_
118	proliferation	proliferation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
119	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 467
# text = Document 003002164 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	003002164	003002164	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 468
# text = The Epstein-Barr virus oncoprotein latent membrane protein 1 engages the tumor necrosis factor receptor-associated proteins TRADD and receptor-interacting protein (RIP) but does not induce apoptosis or require RIP for NF-kappaB activation.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	Epstein	Epstein	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
3	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
4	Barr	Barr	PROPN	NNP	Number=Sing	_	_	_	_
5	virus	virus	NOUN	NN	Number=Sing	_	_	_	_
6	oncoprotein	oncoprotein	ADV	WRB	PronType=Rel	_	_	_	_
7	latent	latent	ADJ	JJ	Degree=Pos	_	_	_	_
8	membrane	membrane	NOUN	NN	Number=Sing	_	_	_	_
9	protein	protein	NOUN	NN	Number=Sing	_	_	_	_
10	1	1	NUM	CD	NumType=Card	_	_	_	_
11	engages	engage	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
12	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
13	tumor	tumor	NOUN	NN	Number=Sing	_	_	_	_
14	necrosis	necrosis	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
15	factor	factor	NOUN	NN	Number=Sing	_	_	_	_
16	receptor-	receptor-	PUNCT	,	_	_	_	_	SpaceAfter=No
17	associated	associate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
18	proteins	protein	NOUN	NNS	Number=Plur	_	_	_	_
19	TRADD	Tradd	NOUN	NN	Number=Sing	_	_	_	_
20	and	and	CCONJ	CC	_	_	_	_	_
21	receptor-	receptor-	PUNCT	,	_	_	_	_	SpaceAfter=No
22	interacting	interact	VERB	VBG	VerbForm=Ger	_	_	_	_
23	protein	protein	NOUN	NN	Number=Sing	_	_	_	_
24	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
25	RIP	rip	INTJ	UH	_	_	_	_	SpaceAfter=No
26	)	)	PUNCT	-RRB-	_	_	_	_	_
27	but	but	CCONJ	CC	_	_	_	_	_
28	does	do	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
29	not	not	PART	RB	_	_	_	_	_
30	induce	induce	VERB	VB	VerbForm=Inf	_	_	_	_
31	apoptosis	apoptosis	NOUN	NN	Number=Sing	_	_	_	_
32	or	or	CCONJ	CC	_	_	_	_	_
33	require	require	VERB	VB	VerbForm=Inf	_	_	_	_
34	RIP	RIP	PROPN	NNP	Number=Sing	_	_	_	_
35	for	for	ADP	IN	_	_	_	_	_
36	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
37	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
38	kappaB	kappaB	PROPN	NNP	Number=Sing	_	_	_	_
39	activation	activation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
40	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 469
# text = A site in the Epstein-Barr virus (EBV) transforming protein LMP1 that constitutively associates with the tumor necrosis factor receptor 1 (TNFR1)-associated death domain protein TRADD to mediate NF-kappaB and c-Jun N-terminal kinase activation is critical for long-term lymphoblastoid cell proliferation.
1	A	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
2	site	site	NOUN	NN	Number=Sing	_	_	_	_
3	in	in	ADP	IN	_	_	_	_	_
4	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
5	Epstein	Epstein	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
6	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
7	Barr	Barr	PROPN	NNP	Number=Sing	_	_	_	_
8	virus	virus	NOUN	NN	Number=Sing	_	_	_	_
9	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
10	EBV	EBV	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
11	)	)	PUNCT	-RRB-	_	_	_	_	_
12	transforming	transform	VERB	VBG	VerbForm=Ger	_	_	_	_
13	protein	protein	NOUN	NN	Number=Sing	_	_	_	_
14	LMP1	Lmp1	NOUN	NN	Number=Sing	_	_	_	_
15	that	that	PRON	WDT	PronType=Rel	_	_	_	_
16	constitutively	constitutively	ADV	RB	_	_	_	_	_
17	associates	associate	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
18	with	with	ADP	IN	_	_	_	_	_
19	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
20	tumor	tumor	NOUN	NN	Number=Sing	_	_	_	_
21	necrosis	necrosis	NOUN	NN	Number=Sing	_	_	_	_
22	factor	factor	NOUN	NN	Number=Sing	_	_	_	_
23	receptor	receptor	NOUN	NN	Number=Sing	_	_	_	_
24	1	1	NUM	CD	NumType=Card	_	_	_	_
25	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
26	TNFR1	TNFR1	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
27	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
28	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
29	associated	associate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
30	death	death	NOUN	NN	Number=Sing	_	_	_	_
31	domain	domain	NOUN	NN	Number=Sing	_	_	_	_
32	protein	protein	NOUN	NN	Number=Sing	_	_	_	_
33	TRADD	TRADD	NOUN	NN	Number=Sing	_	_	_	_
34	to	to	PART	TO	_	_	_	_	_
35	mediate	mediate	VERB	VB	VerbForm=Inf	_	_	_	_
36	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
37	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
38	kappaB	kappaB	PROPN	NNP	Number=Sing	_	_	_	_
39	and	and	CCONJ	CC	_	_	_	_	_
40	c	c	NOUN	NN	Abbr=Yes|Number=Sing	_	_	_	SpaceAfter=No
41	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
42	Jun	Jun	PROPN	NNP	Number=Sing	_	_	_	_
43	N-	N-	PUNCT	:	_	_	_	_	SpaceAfter=No
44	terminal	terminal	ADJ	JJ	Degree=Pos	_	_	_	_
45	kinase	kinase	NOUN	NN	Number=Sing	_	_	_	_
46	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
47	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
48	critical	critical	ADJ	JJ	Degree=Pos	_	_	_	_
49	for	for	ADP	IN	_	_	_	_	_
50	long	long	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
51	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
52	term	term	NOUN	NN	Number=Sing	_	_	_	_
53	lymphoblastoid	lymphoblastoid	NOUN	NN	Number=Sing	_	_	_	_
54	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
55	proliferation	proliferation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
56	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 470
# text = We now find that LMP1 signaling through TRADD differs from TNFR1 signaling through TRADD.
1	We	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
2	now	now	ADV	RB	_	_	_	_	_
3	find	find	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
4	that	that	SCONJ	IN	_	_	_	_	_
5	LMP1	LMP1	PROPN	NNP	Number=Sing	_	_	_	_
6	signaling	signal	VERB	VBG	VerbForm=Ger	_	_	_	_
7	through	through	ADP	IN	_	_	_	_	_
8	TRADD	tRADd	NOUN	NN	Number=Sing	_	_	_	_
9	differs	differ	NOUN	NNS	Number=Plur	_	_	_	_
10	from	from	ADP	IN	_	_	_	_	_
11	TNFR1	TNFR1	PROPN	NNP	Number=Sing	_	_	_	_
12	signaling	signal	VERB	VBG	VerbForm=Ger	_	_	_	_
13	through	through	ADP	IN	_	_	_	_	_
14	TRADD	TRADD	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
15	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 471
# text = LMP1 needs only 11 amino acids to activate NF-kappaB or synergize with TRADD in NF-kappaB activation, while TNFR1 requires approximately 70 residues.
1	LMP1	LMP1	NOUN	NN	Number=Sing	_	_	_	_
2	needs	need	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
3	only	only	ADV	RB	_	_	_	_	_
4	11	11	NUM	CD	NumType=Card	_	_	_	_
5	amino	amino	NOUN	NN	Number=Sing	_	_	_	_
6	acids	acid	NOUN	NNS	Number=Plur	_	_	_	_
7	to	to	PART	TO	_	_	_	_	_
8	activate	activate	VERB	VB	VerbForm=Inf	_	_	_	_
9	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
10	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
11	kappaB	kappaB	PROPN	NNP	Number=Sing	_	_	_	_
12	or	or	CCONJ	CC	_	_	_	_	_
13	synergize	synergize	VERB	VB	VerbForm=Inf	_	_	_	_
14	with	with	ADP	IN	_	_	_	_	_
15	TRADD	tRADd	NOUN	NN	Number=Sing	_	_	_	_
16	in	in	ADP	IN	_	_	_	_	_
17	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
18	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
19	kappaB	kappaB	PROPN	NNP	Number=Sing	_	_	_	_
20	activation	activation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
21	,	,	PUNCT	,	_	_	_	_	_
22	while	while	SCONJ	IN	_	_	_	_	_
23	TNFR1	TNFR1	PROPN	NNP	Number=Sing	_	_	_	_
24	requires	require	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
25	approximately	approximately	ADV	RB	_	_	_	_	_
26	70	70	NUM	CD	NumType=Card	_	_	_	_
27	residues	residue	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
28	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 472
# text = Further, LMP1 does not require TRADD residues 294 to 312 for NF-kappaB activation, while TNFR1 requires TRADD residues 296 to 302.
1	Further	further	ADV	RB	_	_	_	_	SpaceAfter=No
2	,	,	PUNCT	,	_	_	_	_	_
3	LMP1	LMP1	PROPN	NNP	Number=Sing	_	_	_	_
4	does	do	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
5	not	not	PART	RB	_	_	_	_	_
6	require	require	VERB	VB	VerbForm=Inf	_	_	_	_
7	TRADD	tRADd	NOUN	NN	Number=Sing	_	_	_	_
8	residues	residue	NOUN	NNS	Number=Plur	_	_	_	_
9	294	294	NUM	CD	NumType=Card	_	_	_	_
10	to	to	ADP	IN	_	_	_	_	_
11	312	312	NUM	CD	NumType=Card	_	_	_	_
12	for	for	ADP	IN	_	_	_	_	_
13	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
14	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
15	kappaB	kappaB	PROPN	NNP	Number=Sing	_	_	_	_
16	activation	activation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
17	,	,	PUNCT	,	_	_	_	_	_
18	while	while	SCONJ	IN	_	_	_	_	_
19	TNFR1	TNFR1	PROPN	NNP	Number=Sing	_	_	_	_
20	requires	require	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
21	TRADD	Tradd	PROPN	NNP	Number=Sing	_	_	_	_
22	residues	residue	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
23	296	296	NUM	CD	NumType=Card	_	_	_	_
24	to	to	ADP	IN	_	_	_	_	_
25	302	302	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
26	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 473
# text = LMP1 is partially blocked for NF-kappaB activation by a TRADD mutant consisting of residues 122 to 293.
1	LMP1	Lmp1	NOUN	NN	Number=Sing	_	_	_	_
2	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
3	partially	partially	ADV	RB	_	_	_	_	_
4	blocked	block	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
5	for	for	ADP	IN	_	_	_	_	_
6	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
7	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
8	kappaB	kappaB	PROPN	NNP	Number=Sing	_	_	_	_
9	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
10	by	by	ADP	IN	_	_	_	_	_
11	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
12	TRADD	tRADd	NOUN	NN	Number=Sing	_	_	_	_
13	mutant	mutant	NOUN	NN	Number=Sing	_	_	_	_
14	consisting	consisting	NOUN	NN	Number=Sing	_	_	_	_
15	of	of	ADP	IN	_	_	_	_	_
16	residues	residue	NOUN	NNS	Number=Plur	_	_	_	_
17	122	122	NUM	CD	NumType=Card	_	_	_	_
18	to	to	ADP	IN	_	_	_	_	_
19	293	293	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
20	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 474
# text = Unlike TNFR1, LMP1 can interact directly with receptor-interacting protein (RIP) and stably associates with RIP in EBV-transformed lymphoblastoid cell lines.
1	Unlike	unlike	ADP	IN	_	_	_	_	_
2	TNFR1	TNFR1	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
3	,	,	PUNCT	,	_	_	_	_	_
4	LMP1	LMP1	PROPN	NNP	Number=Sing	_	_	_	_
5	can	can	AUX	MD	VerbForm=Fin	_	_	_	_
6	interact	interact	VERB	VB	VerbForm=Inf	_	_	_	_
7	directly	directly	ADV	RB	_	_	_	_	_
8	with	with	ADP	IN	_	_	_	_	_
9	receptor	receptor	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
10	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
11	interacting	interacting	VERB	VBG	VerbForm=Ger	_	_	_	_
12	protein	protein	NOUN	NN	Number=Sing	_	_	_	_
13	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
14	RIP	rip	INTJ	UH	_	_	_	_	SpaceAfter=No
15	)	)	PUNCT	-RRB-	_	_	_	_	_
16	and	and	CCONJ	CC	_	_	_	_	_
17	stably	stably	ADV	RB	_	_	_	_	_
18	associates	associate	NOUN	NNS	Number=Plur	_	_	_	_
19	with	with	ADP	IN	_	_	_	_	_
20	RIP	Rip	PROPN	NNP	Number=Sing	_	_	_	_
21	in	in	ADP	IN	_	_	_	_	_
22	EBV-	EBV-	PUNCT	:	_	_	_	_	SpaceAfter=No
23	transformed	transform	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
24	lymphoblastoid	lymphoblastoid	ADJ	JJ	Degree=Pos	_	_	_	_
25	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
26	lines	line	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
27	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 475
# text = Surprisingly, LMP1 does not require RIP for NF-kappaB activation.
1	Surprisingly	surprisingly	ADV	RB	_	_	_	_	SpaceAfter=No
2	,	,	PUNCT	,	_	_	_	_	_
3	LMP1	LMP1	PROPN	NNP	Number=Sing	_	_	_	_
4	does	do	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
5	not	not	PART	RB	_	_	_	_	_
6	require	require	VERB	VB	VerbForm=Inf	_	_	_	_
7	RIP	Rip	PROPN	NNP	Number=Sing	_	_	_	_
8	for	for	ADP	IN	_	_	_	_	_
9	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
10	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
11	kappaB	kappaB	PROPN	NNP	Number=Sing	_	_	_	_
12	activation	activation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
13	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 476
# text = Despite constitutive association with TRADD or RIP, LMP1 does not induce apoptosis in EBV-negative Burkitt lymphoma or human embryonic kidney 293 cells.
1	Despite	despite	ADP	IN	_	_	_	_	_
2	constitutive	constitutive	ADJ	JJ	Degree=Pos	_	_	_	_
3	association	association	NOUN	NN	Number=Sing	_	_	_	_
4	with	with	ADP	IN	_	_	_	_	_
5	TRADD	tRADd	PROPN	NNP	Number=Sing	_	_	_	_
6	or	or	CCONJ	CC	_	_	_	_	_
7	RIP	rip	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
8	,	,	PUNCT	,	_	_	_	_	_
9	LMP1	LMP1	PROPN	NNP	Number=Sing	_	_	_	_
10	does	do	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
11	not	not	PART	RB	_	_	_	_	_
12	induce	induce	VERB	VB	VerbForm=Inf	_	_	_	_
13	apoptosis	apoptosis	NOUN	NN	Number=Sing	_	_	_	_
14	in	in	ADP	IN	_	_	_	_	_
15	EBV	EBV	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
16	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
17	negative	negative	ADJ	JJ	Degree=Pos	_	_	_	_
18	Burkitt	Burkitt	NOUN	NN	Number=Sing	_	_	_	_
19	lymphoma	lymphoma	NOUN	NN	Number=Sing	_	_	_	_
20	or	or	CCONJ	CC	_	_	_	_	_
21	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
22	embryonic	embryonic	ADJ	JJ	Degree=Pos	_	_	_	_
23	kidney	kidney	NOUN	NN	Number=Sing	_	_	_	_
24	293	293	NUM	CD	NumType=Card	_	_	_	_
25	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
26	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 477
# text = These results add a different perspective to the molecular interactions through which LMP1, TRADD, and RIP participate in B-lymphocyte activation and growth.
1	These	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
2	results	result	NOUN	NNS	Number=Plur	_	_	_	_
3	add	add	VERB	VB	Mood=Imp|VerbForm=Fin	_	_	_	_
4	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
5	different	different	ADJ	JJ	Degree=Pos	_	_	_	_
6	perspective	perspective	NOUN	NN	Number=Sing	_	_	_	_
7	to	to	ADP	IN	_	_	_	_	_
8	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
9	molecular	molecular	ADJ	JJ	Degree=Pos	_	_	_	_
10	interactions	interaction	NOUN	NNS	Number=Plur	_	_	_	_
11	through	through	ADP	IN	_	_	_	_	_
12	which	which	DET	WDT	PronType=Int	_	_	_	_
13	LMP1	LMP1	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
14	,	,	PUNCT	,	_	_	_	_	_
15	TRADD	TRADD	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
16	,	,	PUNCT	,	_	_	_	_	_
17	and	and	CCONJ	CC	_	_	_	_	_
18	RIP	rip	INTJ	UH	_	_	_	_	_
19	participate	participate	VERB	VB	Mood=Imp|VerbForm=Fin	_	_	_	_
20	in	in	ADP	IN	_	_	_	_	_
21	B	b	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
22	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
23	lymphocyte	lymphocyte	NOUN	NN	Number=Sing	_	_	_	_
24	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
25	and	and	CCONJ	CC	_	_	_	_	_
26	growth	growth	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
27	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 478
# text = Document 003002175 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	003002175	003002175	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 479
# text = Inhibition of NF-kappa B activity in human T lymphocytes induces caspase-dependent apoptosis without detectable activation of caspase-1 and -3.
1	Inhibition	Inhibition	NOUN	NN	Number=Sing	_	_	_	_
2	of	of	ADP	IN	_	_	_	_	_
3	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
4	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
5	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_
6	B	b	NOUN	NN	Number=Sing	_	_	_	_
7	activity	activity	NOUN	NN	Number=Sing	_	_	_	_
8	in	in	ADP	IN	_	_	_	_	_
9	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
10	T	T	PROPN	NNP	Number=Sing	_	_	_	_
11	lymphocytes	lymphocyte	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
12	induces	induce	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
13	caspase	caspase	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
14	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
15	dependent	dependent	ADJ	JJ	Degree=Pos	_	_	_	_
16	apoptosis	apoptosis	NOUN	NN	Number=Sing	_	_	_	_
17	without	without	ADP	IN	_	_	_	_	_
18	detectable	detectable	ADJ	JJ	Degree=Pos	_	_	_	_
19	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
20	of	of	ADP	IN	_	_	_	_	_
21	caspase	caspase	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
22	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
23	1	1	NUM	CD	NumType=Card	_	_	_	_
24	and	and	CCONJ	CC	_	_	_	_	_
25	-	-	SYM	SYM	_	_	_	_	SpaceAfter=No
26	3	3	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
27	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 480
# text = NF-kappa B is involved in the transcriptional control of various genes that act as extrinsic and intrinsic survival factors for T cells.
1	NF	Nf	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
2	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
3	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_
4	B	b	NOUN	NN	Number=Sing	_	_	_	_
5	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
6	involved	involved	ADJ	JJ	Degree=Pos	_	_	_	_
7	in	in	ADP	IN	_	_	_	_	_
8	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
9	transcriptional	transcriptional	ADJ	JJ	Degree=Pos	_	_	_	_
10	control	control	NOUN	NN	Number=Sing	_	_	_	_
11	of	of	ADP	IN	_	_	_	_	_
12	various	various	ADJ	JJ	Degree=Pos	_	_	_	_
13	genes	gene	NOUN	NNS	Number=Plur	_	_	_	_
14	that	that	PRON	WDT	PronType=Rel	_	_	_	_
15	act	act	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
16	as	as	ADP	IN	_	_	_	_	_
17	extrinsic	extrinsic	ADJ	JJ	Degree=Pos	_	_	_	_
18	and	and	CCONJ	CC	_	_	_	_	_
19	intrinsic	intrinsic	ADJ	JJ	Degree=Pos	_	_	_	_
20	survival	survival	NOUN	NN	Number=Sing	_	_	_	_
21	factors	factor	NOUN	NNS	Number=Plur	_	_	_	_
22	for	for	ADP	IN	_	_	_	_	_
23	T	t	PROPN	NNP	Number=Sing	_	_	_	_
24	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
25	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 481
# text = Our findings show that suppression of NF-kappa B activity with cell-permeable SN50 peptide, which masks the nuclear localization sequence of NF-kappa B1 dimers and prevents their nuclear localization, induces apoptosis in resting normal human PBL.
1	Our	we	PRON	PRP$	Number=Plur|Person=1|Poss=Yes|PronType=Prs	_	_	_	_
2	findings	finding	NOUN	NNS	Number=Plur	_	_	_	_
3	show	show	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
4	that	that	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
5	suppression	suppression	NOUN	NN	Number=Sing	_	_	_	_
6	of	of	ADP	IN	_	_	_	_	_
7	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
8	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
9	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_
10	B	b	NOUN	NN	Number=Sing	_	_	_	_
11	activity	activity	NOUN	NN	Number=Sing	_	_	_	_
12	with	with	ADP	IN	_	_	_	_	_
13	cell	cell	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
14	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
15	permeable	permeable	ADJ	JJ	Degree=Pos	_	_	_	_
16	SN50	SN50	NOUN	NN	Number=Sing	_	_	_	_
17	peptide	peptide	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
18	,	,	PUNCT	,	_	_	_	_	_
19	which	which	PRON	WDT	PronType=Rel	_	_	_	_
20	masks	mask	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
21	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
22	nuclear	nuclear	ADJ	JJ	Degree=Pos	_	_	_	_
23	localization	localization	NOUN	NN	Number=Sing	_	_	_	_
24	sequence	sequence	NOUN	NN	Number=Sing	_	_	_	_
25	of	of	ADP	IN	_	_	_	_	_
26	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
27	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
28	kappa	kappa	PROPN	NNP	Number=Sing	_	_	_	_
29	B1	b1	PROPN	NNP	Number=Sing	_	_	_	_
30	dimers	dimer	NOUN	NNS	Number=Plur	_	_	_	_
31	and	and	CCONJ	CC	_	_	_	_	_
32	prevents	prevent	NOUN	NNS	Number=Plur	_	_	_	_
33	their	they	PRON	PRP$	Number=Plur|Person=3|Poss=Yes|PronType=Prs	_	_	_	_
34	nuclear	nuclear	ADJ	JJ	Degree=Pos	_	_	_	_
35	localization	localization	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
36	,	,	PUNCT	,	_	_	_	_	_
37	induces	induce	NOUN	NNS	Number=Plur	_	_	_	_
38	apoptosis	apoptosis	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
39	in	in	SCONJ	IN	_	_	_	_	_
40	resting	rest	VERB	VBG	VerbForm=Ger	_	_	_	_
41	normal	normal	ADJ	JJ	Degree=Pos	_	_	_	_
42	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
43	PBL	pBl	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
44	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 482
# text = Inhibition of NF-kappa B resulted in the externalization of phosphatidylserine, induction of DNA breaks, and morphological changes consistent with apoptosis.
1	Inhibition	Inhibition	NOUN	NN	Number=Sing	_	_	_	_
2	of	of	ADP	IN	_	_	_	_	_
3	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
4	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
5	kappa	kappa	PROPN	NNP	Number=Sing	_	_	_	_
6	B	B	PROPN	NNP	Number=Sing	_	_	_	_
7	resulted	result	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
8	in	in	ADP	IN	_	_	_	_	_
9	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
10	externalization	externalization	NOUN	NN	Number=Sing	_	_	_	_
11	of	of	ADP	IN	_	_	_	_	_
12	phosphatidylserine	phosphatidylserine	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
13	,	,	PUNCT	,	_	_	_	_	_
14	induction	induction	NOUN	NN	Number=Sing	_	_	_	_
15	of	of	ADP	IN	_	_	_	_	_
16	DNA	dna	NOUN	NN	Number=Sing	_	_	_	_
17	breaks	break	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
18	,	,	PUNCT	,	_	_	_	_	_
19	and	and	CCONJ	CC	_	_	_	_	_
20	morphological	morphological	ADJ	JJ	Degree=Pos	_	_	_	_
21	changes	change	NOUN	NNS	Number=Plur	_	_	_	_
22	consistent	consistent	ADJ	JJ	Degree=Pos	_	_	_	_
23	with	with	ADP	IN	_	_	_	_	_
24	apoptosis	apoptosis	PRON	DT	Number=Sing|PronType=Dem	_	_	_	SpaceAfter=No
25	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 483
# text = DNA fragmentation was efficiently blocked by the caspase inhibitor Z-VAD-fmk and partially blocked by Ac-DEVD-fmk, suggesting that SN50-mediated apoptosis is caspase-dependent.
1	DNA	dna	NOUN	NN	Number=Sing	_	_	_	_
2	fragmentation	fragmentation	NOUN	NN	Number=Sing	_	_	_	_
3	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
4	efficiently	efficiently	ADV	RB	_	_	_	_	_
5	blocked	block	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
6	by	by	ADP	IN	_	_	_	_	_
7	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
8	caspase	caspase	NOUN	NN	Number=Sing	_	_	_	_
9	inhibitor	inhibitor	NOUN	NN	Number=Sing	_	_	_	_
10	Z	z	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
11	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
12	VAD	Vad	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
13	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
14	fmk	fmk	NOUN	NN	Number=Sing	_	_	_	_
15	and	and	CCONJ	CC	_	_	_	_	_
16	partially	partially	ADV	RB	_	_	_	_	_
17	blocked	block	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
18	by	by	ADP	IN	_	_	_	_	_
19	Ac-	Ac-	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
20	DEVD	Devd	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
21	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
22	fmk	fmk	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
23	,	,	PUNCT	,	_	_	_	_	_
24	suggesting	suggest	VERB	VBG	VerbForm=Ger	_	_	_	_
25	that	that	SCONJ	IN	_	_	_	_	_
26	SN50	SN50	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
27	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
28	mediated	mediate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
29	apoptosis	apoptosis	NOUN	NN	Number=Sing	_	_	_	_
30	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
31	caspase	caspase	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
32	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
33	dependent	dependent	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
34	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 484
# text = Interestingly, apoptosis induced by NF-kappa B suppression, in contrast to that induced by TPEN (N,N,N',N'-tetrakis [2-pyridylmethyl]ethylenediamine) or soluble Fas ligand (CD95), was observed in the absence of active death effector proteases caspase-1-like (IL-1 converting enzyme), caspase-3-like (CPP32/Yama/apopain), and caspase-6-like and without cleavage of caspase-3 substrates poly(ADP-ribose) polymerase and DNA fragmentation factor-45.
1	Interestingly	Interestingly	ADV	RB	_	_	_	_	SpaceAfter=No
2	,	,	PUNCT	,	_	_	_	_	_
3	apoptosis	apoptosis	PRON	PRP$	Gender=Masc|Number=Sing|Person=3|Poss=Yes|PronType=Prs	_	_	_	_
4	induced	induce	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
5	by	by	ADP	IN	_	_	_	_	_
6	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
7	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
8	kappa	kappa	PROPN	NNP	Number=Sing	_	_	_	_
9	B	b	PROPN	NNP	Number=Sing	_	_	_	_
10	suppression	suppression	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
11	,	,	PUNCT	,	_	_	_	_	_
12	in	in	ADP	IN	_	_	_	_	_
13	contrast	contrast	NOUN	NN	Number=Sing	_	_	_	_
14	to	to	ADP	IN	_	_	_	_	_
15	that	that	PRON	DT	Number=Sing|PronType=Dem	_	_	_	_
16	induced	induce	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
17	by	by	ADP	IN	_	_	_	_	_
18	TPEN	TPEN	PROPN	NNP	Number=Sing	_	_	_	_
19	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
20	N,N,N'	N,N,N'	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
21	,	,	PUNCT	,	_	_	_	_	SpaceAfter=No
22	N	N	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
23	'	's	PART	POS	_	_	_	_	SpaceAfter=No
24	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
25	tetrakis	tetrakis	NOUN	NN	Number=Sing	_	_	_	_
26	[	[	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
27	2	2	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
28	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
29	pyridylmethyl	pyridylmethyl	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
30	]	]	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
31	ethylenediamine	ethylenediamine	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
32	)	)	PUNCT	-RRB-	_	_	_	_	_
33	or	or	CCONJ	CC	_	_	_	_	_
34	soluble	soluble	ADJ	JJ	Degree=Pos	_	_	_	_
35	Fas	Fas	PROPN	NNP	Number=Sing	_	_	_	_
36	ligand	ligand	NOUN	NN	Number=Sing	_	_	_	_
37	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
38	CD95	CD95	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
39	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
40	,	,	PUNCT	,	_	_	_	_	_
41	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
42	observed	observe	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
43	in	in	ADP	IN	_	_	_	_	_
44	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
45	absence	absence	NOUN	NN	Number=Sing	_	_	_	_
46	of	of	ADP	IN	_	_	_	_	_
47	active	active	ADJ	JJ	Degree=Pos	_	_	_	_
48	death	death	NOUN	NN	Number=Sing	_	_	_	_
49	effector	effector	NOUN	NN	Number=Sing	_	_	_	_
50	proteases	protease	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
51	caspase	caspase	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
52	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
53	1	1	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
54	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
55	like	like	INTJ	UH	_	_	_	_	_
56	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
57	IL	Il	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
58	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
59	1	1	NUM	CD	NumType=Card	_	_	_	_
60	converting	converting	NOUN	NN	Number=Sing	_	_	_	_
61	enzyme	enzyme	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
62	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
63	,	,	PUNCT	,	_	_	_	_	_
64	caspase	caspase	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
65	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
66	3	3	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
67	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
68	like	like	INTJ	UH	_	_	_	_	_
69	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
70	CPP32/	CPP32/	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
71	Yama/	Yama/	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
72	apopain	apopain	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
73	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
74	,	,	PUNCT	,	_	_	_	_	_
75	and	and	CCONJ	CC	_	_	_	_	_
76	caspase	caspase	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
77	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
78	6	6	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
79	-like	-like	ADJ	JJ	Degree=Pos	_	_	_	_
80	and	and	CCONJ	CC	_	_	_	_	_
81	without	without	ADP	IN	_	_	_	_	_
82	cleavage	cleavage	NOUN	NN	Number=Sing	_	_	_	_
83	of	of	ADP	IN	_	_	_	_	_
84	caspase	caspase	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
85	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
86	3	3	NUM	CD	NumType=Card	_	_	_	_
87	substrates	substrate	NOUN	NNS	Number=Plur	_	_	_	_
88	poly	poly	ADV	RB	_	_	_	_	SpaceAfter=No
89	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
90	ADP	Adp	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
91	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
92	ribose	ribose	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
93	)	)	PUNCT	-RRB-	_	_	_	_	_
94	polymerase	polymerase	NOUN	NN	Number=Sing	_	_	_	_
95	and	and	CCONJ	CC	_	_	_	_	_
96	DNA	dna	NOUN	NN	Number=Sing	_	_	_	_
97	fragmentation	fragmentation	NOUN	NN	Number=Sing	_	_	_	_
98	factor	factor	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
99	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
100	45	45	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
101	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 485
# text = These findings suggest either low level of activation is required or that different caspases are involved.
1	These	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
2	findings	finding	NOUN	NNS	Number=Plur	_	_	_	_
3	suggest	suggest	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
4	either	either	CCONJ	CC	_	_	_	_	_
5	low	low	ADJ	JJ	Degree=Pos	_	_	_	_
6	level	level	NOUN	NN	Number=Sing	_	_	_	_
7	of	of	ADP	IN	_	_	_	_	_
8	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
9	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
10	required	require	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
11	or	or	CCONJ	CC	_	_	_	_	_
12	that	that	PRON	WDT	PronType=Dem	_	_	_	_
13	different	different	ADJ	JJ	Degree=Pos	_	_	_	_
14	caspases	caspase	NOUN	NNS	Number=Plur	_	_	_	_
15	are	be	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
16	involved	involved	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
17	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 486
# text = Preactivation of T cells resulting in NF-kappa B nuclear translocation protected cells from SN50-induced apoptosis.
1	Preactivation	Preactivation	NOUN	NN	Number=Sing	_	_	_	_
2	of	of	ADP	IN	_	_	_	_	_
3	T	t	PROPN	NNP	Number=Sing	_	_	_	_
4	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
5	resulting	result	VERB	VBG	VerbForm=Ger	_	_	_	_
6	in	in	ADP	IN	_	_	_	_	_
7	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
8	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
9	kappa	kappa	PROPN	NNP	Number=Sing	_	_	_	_
10	B	B	PROPN	NNP	Number=Sing	_	_	_	_
11	nuclear	nuclear	ADJ	JJ	Degree=Pos	_	_	_	_
12	translocation	translocation	NOUN	NN	Number=Sing	_	_	_	_
13	protected	protect	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
14	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
15	from	from	ADP	IN	_	_	_	_	_
16	SN50	SN50	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
17	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
18	induced	induce	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
19	apoptosis	apoptosis	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
20	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 487
# text = Our findings demonstrate an essential role of NF-kappa B in survival of naive PBL.
1	Our	we	PRON	PRP$	Number=Plur|Person=1|Poss=Yes|PronType=Prs	_	_	_	_
2	findings	finding	NOUN	NNS	Number=Plur	_	_	_	_
3	demonstrate	demonstrate	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
4	an	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
5	essential	essential	ADJ	JJ	Degree=Pos	_	_	_	_
6	role	role	NOUN	NN	Number=Sing	_	_	_	_
7	of	of	ADP	IN	_	_	_	_	_
8	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
9	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
10	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_
11	B	b	NOUN	NN	Number=Sing	_	_	_	_
12	in	in	ADP	IN	_	_	_	_	_
13	survival	survival	NOUN	NN	Number=Sing	_	_	_	_
14	of	of	ADP	IN	_	_	_	_	_
15	naive	naive	ADJ	JJ	Degree=Pos	_	_	_	_
16	PBL	pBl	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
17	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 488
# text = Document 003002177 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	003002177	003002177	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 489
# text = Dysregulation of monocytic nuclear factor-kappa B by oxidized low-density lipoprotein.
1	Dysregulation	Dysregulation	NOUN	NN	Number=Sing	_	_	_	_
2	of	of	ADP	IN	_	_	_	_	_
3	monocytic	monocytic	ADJ	JJ	Degree=Pos	_	_	_	_
4	nuclear	nuclear	ADJ	JJ	Degree=Pos	_	_	_	_
5	factor	factor	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
6	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
7	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_
8	B	b	NOUN	NN	Number=Sing	_	_	_	_
9	by	by	ADP	IN	_	_	_	_	_
10	oxidized	oxidize	ADJ	JJ	Degree=Pos	_	_	_	_
11	low	low	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
12	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
13	density	density	NOUN	NN	Number=Sing	_	_	_	_
14	lipoprotein	lipoprotein	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
15	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 490
# text = Nuclear factor-kappa B (NF-kappa B)/Rel transcription factors may be involved in atherosclerosis, as is suggested by the presence of activated NF-kappa B in human atherosclerotic lesions.
1	Nuclear	nuclear	ADJ	JJ	Degree=Pos	_	_	_	_
2	factor	factor	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
3	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
4	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_
5	B	b	NOUN	NN	Number=Sing	_	_	_	_
6	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
7	NF	Nf	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
8	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
9	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_
10	B	b	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
11	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
12	/	/	PUNCT	,	_	_	_	_	SpaceAfter=No
13	Rel	Rel	PROPN	NNP	Number=Sing	_	_	_	_
14	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
15	factors	factor	NOUN	NNS	Number=Plur	_	_	_	_
16	may	may	AUX	MD	VerbForm=Fin	_	_	_	_
17	be	be	AUX	VB	VerbForm=Inf	_	_	_	_
18	involved	involved	ADJ	JJ	Degree=Pos	_	_	_	_
19	in	in	ADP	IN	_	_	_	_	_
20	atherosclerosis	atherosclerosis	PRON	DT	Number=Sing|PronType=Dem	_	_	_	SpaceAfter=No
21	,	,	PUNCT	,	_	_	_	_	_
22	as	as	SCONJ	IN	_	_	_	_	_
23	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
24	suggested	suggest	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
25	by	by	ADP	IN	_	_	_	_	_
26	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
27	presence	presence	NOUN	NN	Number=Sing	_	_	_	_
28	of	of	ADP	IN	_	_	_	_	_
29	activated	activate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
30	NF	Nf	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
31	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
32	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_
33	B	b	NOUN	NN	Number=Sing	_	_	_	_
34	in	in	ADP	IN	_	_	_	_	_
35	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
36	atherosclerotic	atherosclerotic	ADJ	JJ	Degree=Pos	_	_	_	_
37	lesions	lesion	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
38	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 491
# text = The aim of the present study was to investigate the effects of oxidized LDL (oxLDL) on the NF-kappa B system in human THP-1 monocytic cells as well as adherent monocytes.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	aim	aim	NOUN	NN	Number=Sing	_	_	_	_
3	of	of	ADP	IN	_	_	_	_	_
4	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
5	present	present	ADJ	JJ	Degree=Pos	_	_	_	_
6	study	study	NOUN	NN	Number=Sing	_	_	_	_
7	was	be	VERB	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
8	to	to	PART	TO	_	_	_	_	_
9	investigate	investigate	VERB	VB	VerbForm=Inf	_	_	_	_
10	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
11	effects	effect	NOUN	NNS	Number=Plur	_	_	_	_
12	of	of	ADP	IN	_	_	_	_	_
13	oxidized	oxidize	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
14	LDL	LDL	NOUN	NN	Number=Sing	_	_	_	_
15	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
16	oxLDL	oxLDL	INTJ	UH	_	_	_	_	SpaceAfter=No
17	)	)	PUNCT	-RRB-	_	_	_	_	_
18	on	on	ADP	IN	_	_	_	_	_
19	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
20	NF	Nf	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
21	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
22	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_
23	B	b	NOUN	NN	Number=Sing	_	_	_	_
24	system	system	NOUN	NN	Number=Sing	_	_	_	_
25	in	in	ADP	IN	_	_	_	_	_
26	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
27	THP	Thp	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
28	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
29	1	1	NUM	CD	NumType=Card	_	_	_	_
30	monocytic	monocytic	ADJ	JJ	Degree=Pos	_	_	_	_
31	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
32	as	as	ADV	RB	_	_	_	_	_
33	well	well	ADV	RB	Degree=Pos	_	_	_	_
34	as	as	ADP	IN	_	_	_	_	_
35	adherent	adherent	ADJ	JJ	Degree=Pos	_	_	_	_
36	monocytes	monocyte	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
37	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 492
# text = Our results demonstrate that short-term incubation of these cells with oxLDL activated p50/p65 containing NF-kappa B dimers and induced the expression of the target gene IL-8.
1	Our	we	PRON	PRP$	Number=Plur|Person=1|Poss=Yes|PronType=Prs	_	_	_	_
2	results	result	NOUN	NNS	Number=Plur	_	_	_	_
3	demonstrate	demonstrate	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
4	that	that	SCONJ	IN	_	_	_	_	_
5	short	short	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
6	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
7	term	term	NOUN	NN	Number=Sing	_	_	_	_
8	incubation	incubation	NOUN	NN	Number=Sing	_	_	_	_
9	of	of	ADP	IN	_	_	_	_	_
10	these	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
11	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
12	with	with	ADP	IN	_	_	_	_	_
13	oxLDL	oxLDL	PROPN	NNP	Number=Sing	_	_	_	_
14	activated	activate	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
15	p50	p50	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
16	/	/	PUNCT	,	_	_	_	_	SpaceAfter=No
17	p65	p65	NOUN	NN	Number=Sing	_	_	_	_
18	containing	contain	VERB	VBG	VerbForm=Ger	_	_	_	_
19	NF	Nf	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
20	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
21	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_
22	B	b	NOUN	NN	Number=Sing	_	_	_	_
23	dimers	dimer	NOUN	NNS	Number=Plur	_	_	_	_
24	and	and	CCONJ	CC	_	_	_	_	_
25	induced	induce	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
26	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
27	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
28	of	of	ADP	IN	_	_	_	_	_
29	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
30	target	target	NOUN	NN	Number=Sing	_	_	_	_
31	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
32	IL	il	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
33	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
34	8	8	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
35	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 493
# text = This activation of NF-kappa B was inhibited by the antioxidant and H2O2 scavenger pyrrolidine dithiocarbamate and the proteasome inhibitor PSI.
1	This	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
2	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
3	of	of	ADP	IN	_	_	_	_	_
4	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
5	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
6	kappa	kappa	PROPN	NNP	Number=Sing	_	_	_	_
7	B	b	PROPN	NNP	Number=Sing	_	_	_	_
8	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
9	inhibited	inhibit	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
10	by	by	ADP	IN	_	_	_	_	_
11	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
12	antioxidant	antioxidant	NOUN	NN	Number=Sing	_	_	_	_
13	and	and	CCONJ	CC	_	_	_	_	_
14	H2O2	H2O2	NUM	CD	NumType=Card	_	_	_	_
15	scavenger	scavenger	NOUN	NN	Number=Sing	_	_	_	_
16	pyrrolidine	pyrrolidine	NOUN	NN	Number=Sing	_	_	_	_
17	dithiocarbamate	dithiocarbamate	NOUN	NN	Number=Sing	_	_	_	_
18	and	and	CCONJ	CC	_	_	_	_	_
19	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
20	proteasome	proteasome	ADJ	JJ	Degree=Pos	_	_	_	_
21	inhibitor	inhibitor	NOUN	NN	Number=Sing	_	_	_	_
22	PSI	pSi	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
23	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 494
# text = The oxLDL-induced NF-kappa B activation was accompanied by an initial depletion of I kappa B-alpha followed by a slight transient increase in the level of this inhibitor protein.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	oxLDL	oxldl	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
3	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
4	induced	induce	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
5	NF	Nf	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
6	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
7	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_
8	B	b	NOUN	NN	Number=Sing	_	_	_	_
9	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
10	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
11	accompanied	accompany	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
12	by	by	ADP	IN	_	_	_	_	_
13	an	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
14	initial	initial	ADJ	JJ	Degree=Pos	_	_	_	_
15	depletion	depletion	NOUN	NN	Number=Sing	_	_	_	_
16	of	of	ADP	IN	_	_	_	_	_
17	I	I	PRON	PRP	Case=Nom|Number=Sing|Person=1|PronType=Prs	_	_	_	_
18	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_
19	B-	B-	PUNCT	,	_	_	_	_	SpaceAfter=No
20	alpha	alpha	ADV	RB	_	_	_	_	_
21	followed	follow	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
22	by	by	ADP	IN	_	_	_	_	_
23	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
24	slight	slight	ADJ	JJ	Degree=Pos	_	_	_	_
25	transient	transient	NOUN	NN	Number=Sing	_	_	_	_
26	increase	increase	NOUN	NN	Number=Sing	_	_	_	_
27	in	in	ADP	IN	_	_	_	_	_
28	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
29	level	level	NOUN	NN	Number=Sing	_	_	_	_
30	of	of	ADP	IN	_	_	_	_	_
31	this	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
32	inhibitor	inhibitor	NOUN	NN	Number=Sing	_	_	_	_
33	protein	protein	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
34	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 495
# text = In contrast, long-term treatment with oxLDL prevented the lipopolysaccharide-induced depletion of I kappa B-alpha, accompanied by an inhibition of both NF-kappa B activation and the expression of tumor necrosis factor-alpha and interleukin-1 beta genes.
1	In	in	ADP	IN	_	_	_	_	_
2	contrast	contrast	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
3	,	,	PUNCT	,	_	_	_	_	_
4	long	long	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
5	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
6	term	term	NOUN	NN	Number=Sing	_	_	_	_
7	treatment	treatment	NOUN	NN	Number=Sing	_	_	_	_
8	with	with	ADP	IN	_	_	_	_	_
9	oxLDL	oxLDL	PROPN	NNP	Number=Sing	_	_	_	_
10	prevented	prevent	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
11	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
12	lipopolysaccharide	lipopolysaccharide	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
13	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
14	induced	induce	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
15	depletion	depletion	NOUN	NN	Number=Sing	_	_	_	_
16	of	of	ADP	IN	_	_	_	_	_
17	I	I	PRON	PRP	Case=Nom|Number=Sing|Person=1|PronType=Prs	_	_	_	_
18	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_
19	B-	B-	PUNCT	,	_	_	_	_	SpaceAfter=No
20	alpha	alpha	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
21	,	,	PUNCT	,	_	_	_	_	_
22	accompanied	accompany	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
23	by	by	ADP	IN	_	_	_	_	_
24	an	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
25	inhibition	inhibition	NOUN	NN	Number=Sing	_	_	_	_
26	of	of	ADP	IN	_	_	_	_	_
27	both	both	CCONJ	CC	_	_	_	_	_
28	NF	Nf	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
29	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
30	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_
31	B	b	NOUN	NN	Number=Sing	_	_	_	_
32	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
33	and	and	CCONJ	CC	_	_	_	_	_
34	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
35	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
36	of	of	ADP	IN	_	_	_	_	_
37	tumor	tumor	NOUN	NN	Number=Sing	_	_	_	_
38	necrosis	necrosis	NOUN	NN	Number=Sing	_	_	_	_
39	factor	factor	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
40	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
41	alpha	alpha	NOUN	NN	Number=Sing	_	_	_	_
42	and	and	CCONJ	CC	_	_	_	_	_
43	interleukin	interleukin	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
44	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
45	1	1	NUM	CD	NumType=Card	_	_	_	_
46	beta	beta	NOUN	NN	Number=Sing	_	_	_	_
47	genes	gene	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
48	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 496
# text = These observations provide additional evidence that oxLDL is a potent modulator of gene expression and suggest that (dys)regulation of NF-kappa B/Rel is likely to play an important role in atherogenesis.
1	These	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
2	observations	observation	NOUN	NNS	Number=Plur	_	_	_	_
3	provide	provide	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
4	additional	additional	ADJ	JJ	Degree=Pos	_	_	_	_
5	evidence	evidence	NOUN	NN	Number=Sing	_	_	_	_
6	that	that	PRON	WDT	PronType=Rel	_	_	_	_
7	oxLDL	oxLDL	PROPN	NNP	Number=Sing	_	_	_	_
8	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
9	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
10	potent	potent	NOUN	NN	Number=Sing	_	_	_	_
11	modulator	modulator	NOUN	NN	Number=Sing	_	_	_	_
12	of	of	ADP	IN	_	_	_	_	_
13	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
14	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
15	and	and	CCONJ	CC	_	_	_	_	_
16	suggest	suggest	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
17	that	that	PRON	DT	Number=Sing|PronType=Dem	_	_	_	_
18	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
19	dys	dy	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
20	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
21	regulation	regulation	NOUN	NN	Number=Sing	_	_	_	_
22	of	of	ADP	IN	_	_	_	_	_
23	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
24	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
25	kappa	kappa	PROPN	NNP	Number=Sing	_	_	_	_
26	B	b	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
27	/	/	PUNCT	,	_	_	_	_	SpaceAfter=No
28	Rel	Rel	PROPN	NNP	Number=Sing	_	_	_	_
29	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
30	likely	likely	ADJ	JJ	Degree=Pos	_	_	_	_
31	to	to	PART	TO	_	_	_	_	_
32	play	play	VERB	VB	VerbForm=Inf	_	_	_	_
33	an	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
34	important	important	ADJ	JJ	Degree=Pos	_	_	_	_
35	role	role	NOUN	NN	Number=Sing	_	_	_	_
36	in	in	ADP	IN	_	_	_	_	_
37	atherogenesis	atherogenesis	PRON	DT	Number=Sing|PronType=Dem	_	_	_	SpaceAfter=No
38	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 497
# text = Document 003002181 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	003002181	003002181	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 498
# text = The interleukin-8 AP-1 and kappa
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	interleukin	interleukin	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
3	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
4	8	8	NUM	CD	NumType=Card	_	_	_	_
5	AP	ap	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
6	-	-	SYM	SYM	_	_	_	_	SpaceAfter=No
7	1	1	NUM	CD	NumType=Card	_	_	_	_
8	and	and	CCONJ	CC	_	_	_	_	_
9	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_

# sent_id = 499
# text = B-like sites are genetic end targets of FK506-sensitive pathway accompanied by calcium mobilization.
1	B	b	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
2	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
3	like	like	ADJ	JJ	Degree=Pos	_	_	_	_
4	sites	site	NOUN	NNS	Number=Plur	_	_	_	_
5	are	be	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
6	genetic	genetic	ADJ	JJ	Degree=Pos	_	_	_	_
7	end	end	NOUN	NN	Number=Sing	_	_	_	_
8	targets	target	NOUN	NNS	Number=Plur	_	_	_	_
9	of	of	ADP	IN	_	_	_	_	_
10	FK506	FK506	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
11	-	-	PUNCT	:	_	_	_	_	SpaceAfter=No
12	sensitive	sensitive	ADJ	JJ	Degree=Pos	_	_	_	_
13	pathway	pathway	NOUN	NN	Number=Sing	_	_	_	_
14	accompanied	accompany	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
15	by	by	ADP	IN	_	_	_	_	_
16	calcium	calcium	NOUN	NN	Number=Sing	_	_	_	_
17	mobilization	mobilization	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
18	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 500
# text = FK506, an immunosuppressant, inhibits the production of several cytokines in T lymphocytes.
1	FK506	FK506	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
2	,	,	PUNCT	,	_	_	_	_	_
3	an	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
4	immunosuppressant	immunosuppressant	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
5	,	,	PUNCT	,	_	_	_	_	_
6	inhibits	inhibits	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
7	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
8	production	production	NOUN	NN	Number=Sing	_	_	_	_
9	of	of	ADP	IN	_	_	_	_	_
10	several	several	ADJ	JJ	Degree=Pos	_	_	_	_
11	cytokines	cytokine	NOUN	NNS	Number=Plur	_	_	_	_
12	in	in	ADP	IN	_	_	_	_	_
13	T	t	PROPN	NNP	Number=Sing	_	_	_	_
14	lymphocytes	lymphocyte	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
15	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 501
# text = We observed that FK506 suppressed the transcription of a chemotactic cytokine, interleukin-8 (IL-8) in a human T cell line, Jurkat cells, activated by phorbol 12-myristate 13-acetate (PMA) and calcium (Ca2+) ionophore (ionomycin).
1	We	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
2	observed	observe	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
3	that	that	SCONJ	IN	_	_	_	_	_
4	FK506	FK506	PROPN	NNP	Number=Sing	_	_	_	_
5	suppressed	suppress	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
6	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
7	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
8	of	of	ADP	IN	_	_	_	_	_
9	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
10	chemotactic	chemotactic	ADJ	JJ	Degree=Pos	_	_	_	_
11	cytokine	cytokine	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
12	,	,	PUNCT	,	_	_	_	_	_
13	interleukin	interleukin	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
14	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
15	8	8	NUM	CD	NumType=Card	_	_	_	_
16	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
17	IL	Il	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
18	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
19	8	8	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
20	)	)	PUNCT	-RRB-	_	_	_	_	_
21	in	in	ADP	IN	_	_	_	_	_
22	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
23	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
24	T	T	PROPN	NNP	Number=Sing	_	_	_	_
25	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
26	line	line	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
27	,	,	PUNCT	,	_	_	_	_	_
28	Jurkat	Jurkat	PROPN	NNP	Number=Sing	_	_	_	_
29	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
30	,	,	PUNCT	,	_	_	_	_	_
31	activated	activate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
32	by	by	ADP	IN	_	_	_	_	_
33	phorbol	phorbol	NOUN	NN	Number=Sing	_	_	_	_
34	12	12	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
35	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
36	myristate	myristate	NOUN	NN	Number=Sing	_	_	_	_
37	13	13	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
38	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
39	acetate	acetate	NOUN	NN	Number=Sing	_	_	_	_
40	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
41	PMA	PMA	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
42	)	)	PUNCT	-RRB-	_	_	_	_	_
43	and	and	CCONJ	CC	_	_	_	_	_
44	calcium	calcium	NOUN	NN	Number=Sing	_	_	_	_
45	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
46	Ca2	Ca2	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
47	+	+	SYM	SYM	_	_	_	_	SpaceAfter=No
48	)	)	PUNCT	-RRB-	_	_	_	_	_
49	ionophore	ionophore	ADJ	JJ	Degree=Pos	_	_	_	_
50	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
51	ionomycin	ionomycin	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
52	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
53	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 502
# text = By deleted and mutated analysis of the IL-8 promoters, the AP-1 and kappa B-like sites were identified as the responsive elements for PMA and ionomycin.
1	By	by	ADP	IN	_	_	_	_	_
2	deleted	delet	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
3	and	and	CCONJ	CC	_	_	_	_	_
4	mutated	mutate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
5	analysis	analysis	NOUN	NN	Number=Sing	_	_	_	_
6	of	of	ADP	IN	_	_	_	_	_
7	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
8	IL	Il	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
9	-	-	SYM	SYM	_	_	_	_	SpaceAfter=No
10	8	8	NUM	CD	NumType=Card	_	_	_	_
11	promoters	promoter	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
12	,	,	PUNCT	,	_	_	_	_	_
13	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
14	AP	ap	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
15	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
16	1	1	NUM	CD	NumType=Card	_	_	_	_
17	and	and	CCONJ	CC	_	_	_	_	_
18	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_
19	B	b	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
20	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
21	like	like	SCONJ	IN	_	_	_	_	_
22	sites	site	NOUN	NNS	Number=Plur	_	_	_	_
23	were	be	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
24	identified	identify	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
25	as	as	ADP	IN	_	_	_	_	_
26	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
27	responsive	responsive	ADJ	JJ	Degree=Pos	_	_	_	_
28	elements	element	NOUN	NNS	Number=Plur	_	_	_	_
29	for	for	ADP	IN	_	_	_	_	_
30	PMA	PMA	PROPN	NNP	Number=Sing	_	_	_	_
31	and	and	CCONJ	CC	_	_	_	_	_
32	ionomycin	ionomycin	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
33	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 503
# text = FK506 suppressed the transcriptions through the AP-1 or kappa B-like sites induced by PMA plus Ca(2+)-mobilizing agents, but not those induced by Ca(2+)-independent stimuli.
1	FK506	FK506	PROPN	NNP	Number=Sing	_	_	_	_
2	suppressed	suppress	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
3	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
4	transcriptions	transcription	NOUN	NNS	Number=Plur	_	_	_	_
5	through	through	ADP	IN	_	_	_	_	_
6	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
7	AP	ap	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
8	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
9	1	1	NUM	CD	NumType=Card	_	_	_	_
10	or	or	CCONJ	CC	_	_	_	_	_
11	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_
12	B	b	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
13	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
14	like	like	SCONJ	IN	_	_	_	_	_
15	sites	site	NOUN	NNS	Number=Plur	_	_	_	_
16	induced	induce	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
17	by	by	ADP	IN	_	_	_	_	_
18	PMA	PMA	PROPN	NNP	Number=Sing	_	_	_	_
19	plus	plus	CCONJ	CC	_	_	_	_	_
20	Ca	ca	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
21	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
22	2	2	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
23	+)	+)	SYM	NFP	_	_	_	_	SpaceAfter=No
24	-	-	SYM	SYM	_	_	_	_	SpaceAfter=No
25	mobilizing	mobilizing	ADJ	JJ	Degree=Pos	_	_	_	_
26	agents	agent	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
27	,	,	PUNCT	,	_	_	_	_	_
28	but	but	CCONJ	CC	_	_	_	_	_
29	not	not	ADV	RB	_	_	_	_	_
30	those	those	PRON	DT	Number=Plur|PronType=Dem	_	_	_	_
31	induced	induce	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
32	by	by	ADP	IN	_	_	_	_	_
33	Ca	Ca	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
34	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
35	2	2	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
36	+)	+)	SYM	NFP	_	_	_	_	SpaceAfter=No
37	-	-	SYM	SYM	_	_	_	_	SpaceAfter=No
38	independent	independent	ADJ	JJ	Degree=Pos	_	_	_	_
39	stimuli	stimuli	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
40	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 504
# text = In gel retardation analysis, FK506 had little effect on the binding to the AP-1 site of PMA/ionomycin-induced nuclear factors, which were recognized with anti-JunD or c-Fos antibody.
1	In	in	ADP	IN	_	_	_	_	_
2	gel	gel	NOUN	NN	Number=Sing	_	_	_	_
3	retardation	retardation	NOUN	NN	Number=Sing	_	_	_	_
4	analysis	analysis	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
5	,	,	PUNCT	,	_	_	_	_	_
6	FK506	FK506	NUM	CD	NumType=Card	_	_	_	_
7	had	have	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
8	little	little	ADJ	JJ	Degree=Pos	_	_	_	_
9	effect	effect	NOUN	NN	Number=Sing	_	_	_	_
10	on	on	ADP	IN	_	_	_	_	_
11	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
12	binding	binding	VERB	VBG	VerbForm=Ger	_	_	_	_
13	to	to	ADP	IN	_	_	_	_	_
14	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
15	AP	ap	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
16	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
17	1	1	NUM	CD	NumType=Card	_	_	_	_
18	site	site	NOUN	NN	Number=Sing	_	_	_	_
19	of	of	ADP	IN	_	_	_	_	_
20	PMA/ionomycin-induced	PMA/ionomycin-induced	ADJ	JJ	Degree=Pos	_	_	_	_
21	nuclear	nuclear	ADJ	JJ	Degree=Pos	_	_	_	_
22	factors	factor	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
23	,	,	PUNCT	,	_	_	_	_	_
24	which	which	PRON	WDT	PronType=Rel	_	_	_	_
25	were	be	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
26	recognized	recognize	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
27	with	with	ADP	IN	_	_	_	_	_
28	anti-JunD	anti-jund	NOUN	NN	Number=Sing	_	_	_	_
29	or	or	CCONJ	CC	_	_	_	_	_
30	c	c	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
31	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
32	Fos	Fos	ADJ	JJ	Degree=Pos	_	_	_	_
33	antibody	antibody	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
34	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 505
# text = In contrast, FK506 or EGTA (Ca2+ chelator) similarly affected the formation of kappa B-like site binding complexes, which were not recognized by any antibodies against the human Rel family proteins (c-Rel, p65, p50, and p49).
1	In	in	ADP	IN	_	_	_	_	_
2	contrast	contrast	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
3	,	,	PUNCT	,	_	_	_	_	_
4	FK506	FK506	NUM	CD	NumType=Card	_	_	_	_
5	or	or	CCONJ	CC	_	_	_	_	_
6	EGTA	EGTA	PROPN	NNP	Number=Sing	_	_	_	_
7	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
8	Ca2	Ca2	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
9	+	+	SYM	SYM	_	_	_	_	_
10	chelator	chelator	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
11	)	)	PUNCT	-RRB-	_	_	_	_	_
12	similarly	similarly	ADV	RB	_	_	_	_	_
13	affected	affect	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
14	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
15	formation	formation	NOUN	NN	Number=Sing	_	_	_	_
16	of	of	ADP	IN	_	_	_	_	_
17	kappa	kappa	PROPN	NNP	Number=Sing	_	_	_	_
18	B	b	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
19	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
20	like	like	ADJ	JJ	Degree=Pos	_	_	_	_
21	site	site	NOUN	NN	Number=Sing	_	_	_	_
22	binding	binding	VERB	VBG	VerbForm=Ger	_	_	_	_
23	complexes	complex	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
24	,	,	PUNCT	,	_	_	_	_	_
25	which	which	PRON	WDT	PronType=Rel	_	_	_	_
26	were	be	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
27	not	not	PART	RB	_	_	_	_	_
28	recognized	recognize	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
29	by	by	ADP	IN	_	_	_	_	_
30	any	any	DET	DT	_	_	_	_	_
31	antibodies	antibody	NOUN	NNS	Number=Plur	_	_	_	_
32	against	against	ADP	IN	_	_	_	_	_
33	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
34	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
35	Rel	Rel	NOUN	NN	Number=Sing	_	_	_	_
36	family	family	NOUN	NN	Number=Sing	_	_	_	_
37	proteins	protein	NOUN	NNS	Number=Plur	_	_	_	_
38	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
39	c	c	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
40	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
41	Rel	Rel	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
42	,	,	PUNCT	,	_	_	_	_	_
43	p65	p65	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
44	,	,	PUNCT	,	_	_	_	_	_
45	p50	p50	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
46	,	,	PUNCT	,	_	_	_	_	_
47	and	and	CCONJ	CC	_	_	_	_	_
48	p49	p49	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
49	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
50	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 506
# text = Furthermore, we confirmed the previous report that FK506 suppressed the PMA/ionomycin-induced activation through authentic kappa B site of immunoglobulin
1	Furthermore	furthermore	ADV	RB	_	_	_	_	SpaceAfter=No
2	,	,	PUNCT	,	_	_	_	_	_
3	we	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
4	confirmed	confirm	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
5	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
6	previous	previous	ADJ	JJ	Degree=Pos	_	_	_	_
7	report	report	NOUN	NN	Number=Sing	_	_	_	_
8	that	that	PRON	WDT	PronType=Rel	_	_	_	_
9	FK506	FK506	PROPN	NNP	Number=Sing	_	_	_	_
10	suppressed	suppress	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
11	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
12	PMA/ionomycin-induced	PMA/ionomycin-induced	ADJ	JJ	Degree=Pos	_	_	_	_
13	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
14	through	through	ADP	IN	_	_	_	_	_
15	authentic	authentic	ADJ	JJ	Degree=Pos	_	_	_	_
16	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_
17	B	b	NOUN	NN	Number=Sing	_	_	_	_
18	site	site	NOUN	NN	Number=Sing	_	_	_	_
19	of	of	ADP	IN	_	_	_	_	_
20	immunoglobulin	immunoglobulin	NOUN	NN	Number=Sing	_	_	_	_

# sent_id = 507
# text = (Ig) gene, to which NF-kappa B binding was also decreased by FK506, indicating that both IL-8 kappa B-like site and Ig kappa B site are FK506-sensitive in spite of the difference of binding factors.
1	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
2	Ig	ig	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
3	)	)	PUNCT	-RRB-	_	_	_	_	_
4	gene	gene	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
5	,	,	PUNCT	,	_	_	_	_	_
6	to	to	ADP	IN	_	_	_	_	_
7	which	which	PRON	WDT	PronType=Rel	_	_	_	_
8	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
9	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
10	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_
11	B	b	NOUN	NN	Number=Sing	_	_	_	_
12	binding	binding	VERB	VBG	VerbForm=Ger	_	_	_	_
13	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
14	also	also	ADV	RB	_	_	_	_	_
15	decreased	decrease	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
16	by	by	ADP	IN	_	_	_	_	_
17	FK506	FK506	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
18	,	,	PUNCT	,	_	_	_	_	_
19	indicating	indicate	VERB	VBG	VerbForm=Ger	_	_	_	_
20	that	that	SCONJ	IN	_	_	_	_	_
21	both	both	DET	DT	_	_	_	_	_
22	IL	Il	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
23	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
24	8	8	NUM	CD	NumType=Card	_	_	_	_
25	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_
26	B	b	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
27	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
28	like	like	ADJ	JJ	Degree=Pos	_	_	_	_
29	site	site	NOUN	NN	Number=Sing	_	_	_	_
30	and	and	CCONJ	CC	_	_	_	_	_
31	Ig	ig	PROPN	NNP	Number=Sing	_	_	_	_
32	kappa	kappa	PROPN	NNP	Number=Sing	_	_	_	_
33	B	B	PROPN	NNP	Number=Sing	_	_	_	_
34	site	site	NOUN	NN	Number=Sing	_	_	_	_
35	are	be	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
36	FK506	FK506	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
37	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
38	sensitive	sensitive	ADJ	JJ	Degree=Pos	_	_	_	_
39	in	in	ADP	IN	_	_	_	_	_
40	spite	spite	NOUN	NN	Number=Sing	_	_	_	_
41	of	of	ADP	IN	_	_	_	_	_
42	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
43	difference	difference	NOUN	NN	Number=Sing	_	_	_	_
44	of	of	SCONJ	IN	_	_	_	_	_
45	binding	bind	VERB	VBG	VerbForm=Ger	_	_	_	_
46	factors	factor	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
47	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 508
# text = Our results indicate that not only the reported IL-2 NF-AT and NFIL-2A sites and Ig kappa B site, but also the IL-8 AP-1 and kappa B-like sites are terminals of FK506-sensitive pathway involving Ca2+ mobilization.
1	Our	we	PRON	PRP$	Number=Plur|Person=1|Poss=Yes|PronType=Prs	_	_	_	_
2	results	result	NOUN	NNS	Number=Plur	_	_	_	_
3	indicate	indicate	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
4	that	that	SCONJ	IN	_	_	_	_	_
5	not	not	ADV	RB	_	_	_	_	_
6	only	only	ADV	RB	_	_	_	_	_
7	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
8	reported	report	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
9	IL	Il	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
10	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
11	2	2	NUM	CD	NumType=Card	_	_	_	_
12	NF	Nf	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
13	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
14	AT	at	NOUN	NN	Number=Sing	_	_	_	_
15	and	and	CCONJ	CC	_	_	_	_	_
16	NFIL	Nfil	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
17	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
18	2	2	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
19	A	a	NOUN	NN	Number=Sing	_	_	_	_
20	sites	site	NOUN	NNS	Number=Plur	_	_	_	_
21	and	and	CCONJ	CC	_	_	_	_	_
22	Ig	ig	PROPN	NNP	Number=Sing	_	_	_	_
23	kappa	kappa	PROPN	NNP	Number=Sing	_	_	_	_
24	B	B	PROPN	NNP	Number=Sing	_	_	_	_
25	site	site	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
26	,	,	PUNCT	,	_	_	_	_	_
27	but	but	CCONJ	CC	_	_	_	_	_
28	also	also	ADV	RB	_	_	_	_	_
29	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
30	IL	il	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
31	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
32	8	8	NUM	CD	NumType=Card	_	_	_	_
33	AP	ap	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
34	-	-	SYM	SYM	_	_	_	_	SpaceAfter=No
35	1	1	NUM	CD	NumType=Card	_	_	_	_
36	and	and	CCONJ	CC	_	_	_	_	_
37	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_
38	B	b	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
39	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
40	like	like	SCONJ	IN	_	_	_	_	_
41	sites	site	NOUN	NNS	Number=Plur	_	_	_	_
42	are	be	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
43	terminals	terminal	NOUN	NNS	Number=Plur	_	_	_	_
44	of	of	ADP	IN	_	_	_	_	_
45	FK506	FK506	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
46	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
47	sensitive	sensitive	ADJ	JJ	Degree=Pos	_	_	_	_
48	pathway	pathway	NOUN	NN	Number=Sing	_	_	_	_
49	involving	involve	VERB	VBG	VerbForm=Ger	_	_	_	_
50	Ca2	Ca2	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
51	+	+	SYM	SYM	_	_	_	_	_
52	mobilization	mobilization	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
53	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 509
# text = Document 003002182 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	003002182	003002182	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 510
# text = Interactions of a transcriptional activator in the env gene of the mouse mammary tumor virus with activation-dependent, T cell-specific transacting factors.
1	Interactions	Interaction	NOUN	NNS	Number=Plur	_	_	_	_
2	of	of	ADP	IN	_	_	_	_	_
3	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
4	transcriptional	transcriptional	ADJ	JJ	Degree=Pos	_	_	_	_
5	activator	activator	NOUN	NN	Number=Sing	_	_	_	_
6	in	in	ADP	IN	_	_	_	_	_
7	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
8	env	env	NOUN	NN	Number=Sing	_	_	_	_
9	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
10	of	of	ADP	IN	_	_	_	_	_
11	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
12	mouse	mouse	NOUN	NN	Number=Sing	_	_	_	_
13	mammary	mammary	ADJ	JJ	Degree=Pos	_	_	_	_
14	tumor	tumor	NOUN	NN	Number=Sing	_	_	_	_
15	virus	virus	NOUN	NN	Number=Sing	_	_	_	_
16	with	with	ADP	IN	_	_	_	_	_
17	activation	activation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
18	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
19	dependent	dependent	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
20	,	,	PUNCT	,	_	_	_	_	_
21	T	t	PROPN	NNP	Number=Sing	_	_	_	_
22	cell	cell	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
23	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
24	specific	specific	ADJ	JJ	Degree=Pos	_	_	_	_
25	transacting	transacting	NOUN	NN	Number=Sing	_	_	_	_
26	factors	factor	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
27	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 511
# text = The mouse mammary tumor virus env gene contains a transcriptional activator (META) that can control transcription of the adjacent long terminal repeat region.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	mouse	mouse	NOUN	NN	Number=Sing	_	_	_	_
3	mammary	mammary	NOUN	NN	Number=Sing	_	_	_	_
4	tumor	tumor	NOUN	NN	Number=Sing	_	_	_	_
5	virus	virus	NOUN	NN	Number=Sing	_	_	_	_
6	env	env	NOUN	NN	Number=Sing	_	_	_	_
7	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
8	contains	contain	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
9	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
10	transcriptional	transcriptional	ADJ	JJ	Degree=Pos	_	_	_	_
11	activator	activator	NOUN	NN	Number=Sing	_	_	_	_
12	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
13	META	META	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
14	)	)	PUNCT	-RRB-	_	_	_	_	_
15	that	that	PRON	WDT	PronType=Rel	_	_	_	_
16	can	can	AUX	MD	VerbForm=Fin	_	_	_	_
17	control	control	VERB	VB	VerbForm=Inf	_	_	_	_
18	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
19	of	of	ADP	IN	_	_	_	_	_
20	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
21	adjacent	adjacent	ADJ	JJ	Degree=Pos	_	_	_	_
22	long	long	ADJ	JJ	Degree=Pos	_	_	_	_
23	terminal	terminal	NOUN	NN	Number=Sing	_	_	_	_
24	repeat	repeat	NOUN	NN	Number=Sing	_	_	_	_
25	region	region	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
26	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 512
# text = Transcriptional control by META parallels that of several lymphokine genes, being specific to T cells, dependent on their activation, and inhibited by the immunosuppressive drug cyclosporine (CsA).
1	Transcriptional	Transcriptional	ADJ	JJ	Degree=Pos	_	_	_	_
2	control	control	NOUN	NN	Number=Sing	_	_	_	_
3	by	by	ADP	IN	_	_	_	_	_
4	META	META	PROPN	NNP	Number=Sing	_	_	_	_
5	parallels	parallel	NOUN	NNS	Number=Plur	_	_	_	_
6	that	that	ADV	WRB	PronType=Rel	_	_	_	_
7	of	of	ADP	IN	_	_	_	_	_
8	several	several	ADJ	JJ	Degree=Pos	_	_	_	_
9	lymphokine	lymphokine	NOUN	NN	Number=Sing	_	_	_	_
10	genes	gene	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
11	,	,	PUNCT	,	_	_	_	_	_
12	being	be	AUX	VBG	VerbForm=Ger	_	_	_	_
13	specific	specific	ADJ	JJ	Degree=Pos	_	_	_	_
14	to	to	ADP	IN	_	_	_	_	_
15	T	t	PROPN	NNP	Number=Sing	_	_	_	_
16	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
17	,	,	PUNCT	,	_	_	_	_	_
18	dependent	dependent	ADJ	JJ	Degree=Pos	_	_	_	_
19	on	on	ADP	IN	_	_	_	_	_
20	their	they	PRON	PRP$	Number=Plur|Person=3|Poss=Yes|PronType=Prs	_	_	_	_
21	activation	activation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
22	,	,	PUNCT	,	_	_	_	_	_
23	and	and	CCONJ	CC	_	_	_	_	_
24	inhibited	inhibit	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
25	by	by	ADP	IN	_	_	_	_	_
26	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
27	immunosuppressive	immunosuppressive	ADJ	JJ	Degree=Pos	_	_	_	_
28	drug	drug	NOUN	NN	Number=Sing	_	_	_	_
29	cyclosporine	cyclosporine	NOUN	NN	Number=Sing	_	_	_	_
30	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
31	CsA	csa	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
32	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
33	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 513
# text = DNase I footprinting indicated that nuclear factors from activated T lymphocytes bound a promoter-proximal site, META(P), and a promoter-distal site, META(D+), within the 400-base pair META region.
1	DNase	DNase	INTJ	UH	_	_	_	_	_
2	I	I	PRON	PRP	Case=Nom|Number=Sing|Person=1|PronType=Prs	_	_	_	_
3	footprinting	footprint	VERB	VBG	VerbForm=Ger	_	_	_	_
4	indicated	indicate	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
5	that	that	SCONJ	IN	_	_	_	_	_
6	nuclear	nuclear	ADJ	JJ	Degree=Pos	_	_	_	_
7	factors	factor	NOUN	NNS	Number=Plur	_	_	_	_
8	from	from	ADP	IN	_	_	_	_	_
9	activated	activate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
10	T	t	PROPN	NNP	Number=Sing	_	_	_	_
11	lymphocytes	lymphocyte	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
12	bound	bound	ADP	IN	_	_	_	_	_
13	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
14	promoter	promoter	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
15	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
16	proximal	proximal	ADJ	JJ	Degree=Pos	_	_	_	_
17	site	site	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
18	,	,	PUNCT	,	_	_	_	_	_
19	META	META	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
20	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
21	P	P	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
22	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
23	,	,	PUNCT	,	_	_	_	_	_
24	and	and	CCONJ	CC	_	_	_	_	_
25	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
26	promoter	promoter	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
27	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
28	distal	distal	ADJ	JJ	Degree=Pos	_	_	_	_
29	site	site	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
30	,	,	PUNCT	,	_	_	_	_	_
31	META	META	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
32	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
33	D	d	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
34	+	+	SYM	SYM	_	_	_	_	SpaceAfter=No
35	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
36	,	,	PUNCT	,	_	_	_	_	_
37	within	within	ADP	IN	_	_	_	_	_
38	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
39	400	400	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
40	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
41	base	base	NOUN	NN	Number=Sing	_	_	_	_
42	pair	pair	NOUN	NN	Number=Sing	_	_	_	_
43	META	Meof	ADP	IN	Abbr=Yes	_	_	_	_
44	region	region	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
45	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 514
# text = Nuclear factors from unstimulated, but not from activated cells, bound a site, META(D-), adjacent to META(D+).
1	Nuclear	nuclear	ADJ	JJ	Degree=Pos	_	_	_	_
2	factors	factor	NOUN	NNS	Number=Plur	_	_	_	_
3	from	from	ADP	IN	_	_	_	_	_
4	unstimulated	unstimulated	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
5	,	,	PUNCT	,	_	_	_	_	_
6	but	but	CCONJ	CC	_	_	_	_	_
7	not	not	ADV	RB	_	_	_	_	_
8	from	from	ADP	IN	_	_	_	_	_
9	activated	activate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
10	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
11	,	,	PUNCT	,	_	_	_	_	_
12	bound	bound	ADP	IN	_	_	_	_	_
13	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
14	site	site	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
15	,	,	PUNCT	,	_	_	_	_	_
16	META	META	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
17	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
18	D	d	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
19	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
20	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
21	,	,	PUNCT	,	_	_	_	_	_
22	adjacent	adjacent	ADJ	JJ	Degree=Pos	_	_	_	_
23	to	to	ADP	IN	_	_	_	_	_
24	META	META	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
25	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
26	D	D	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
27	+)	+)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
28	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 515
# text = META(D+) directed transcription of a linked luciferase gene, and gel shift analysis revealed binding of inducible, CsA-sensitive T cell factors, in parallel with transfection results.
1	META	META	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
2	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
3	D	would	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
4	+	+	SYM	SYM	_	_	_	_	SpaceAfter=No
5	)	)	PUNCT	-RRB-	_	_	_	_	_
6	directed	direct	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
7	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
8	of	of	ADP	IN	_	_	_	_	_
9	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
10	linked	link	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
11	luciferase	luciferase	NOUN	NN	Number=Sing	_	_	_	_
12	gene	gene	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
13	,	,	PUNCT	,	_	_	_	_	_
14	and	and	CCONJ	CC	_	_	_	_	_
15	gel	gel	NOUN	NN	Number=Sing	_	_	_	_
16	shift	shift	NOUN	NN	Number=Sing	_	_	_	_
17	analysis	analysis	NOUN	NN	Number=Sing	_	_	_	_
18	revealed	reveal	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
19	binding	binding	VERB	VBG	VerbForm=Ger	_	_	_	_
20	of	of	ADP	IN	_	_	_	_	_
21	inducible	inducible	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
22	,	,	PUNCT	,	_	_	_	_	_
23	CsA	csa	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
24	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
25	sensitive	sensitive	ADJ	JJ	Degree=Pos	_	_	_	_
26	T	t	NOUN	NN	Number=Sing	_	_	_	_
27	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
28	factors	factor	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
29	,	,	PUNCT	,	_	_	_	_	_
30	in	in	ADP	IN	_	_	_	_	_
31	parallel	parallel	NOUN	NN	Number=Sing	_	_	_	_
32	with	with	ADP	IN	_	_	_	_	_
33	transfection	transfection	NOUN	NN	Number=Sing	_	_	_	_
34	results	result	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
35	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 516
# text = Authentic NFAT and NF-kappaB targets did not compete for the META(D+) binding factor(s).
1	Authentic	authentic	PROPN	NNP	Number=Sing	_	_	_	_
2	NFAT	NFAT	PROPN	NNP	Number=Sing	_	_	_	_
3	and	and	CCONJ	CC	_	_	_	_	_
4	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
5	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
6	kappaB	kappaB	PROPN	NNP	Number=Sing	_	_	_	_
7	targets	target	NOUN	NNS	Number=Plur	_	_	_	_
8	did	do	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
9	not	not	PART	RB	_	_	_	_	_
10	compete	compete	VERB	VB	VerbForm=Inf	_	_	_	_
11	for	for	ADP	IN	_	_	_	_	_
12	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
13	META	METa	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
14	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
15	D	d	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
16	+	+	SYM	SYM	_	_	_	_	SpaceAfter=No
17	)	)	PUNCT	-RRB-	_	_	_	_	_
18	binding	bind	VERB	VBG	VerbForm=Ger	_	_	_	_
19	factor	factor	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
20	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
21	s	s	X	AFX	_	_	_	_	SpaceAfter=No
22	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
23	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 517
# text = The SV40 core sequence competed for META(D+) binding factors, but META(D+) failed to compete for the complexes obtained with the SV40 probe.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	SV40	SV40	NUM	CD	NumType=Card	_	_	_	_
3	core	core	NOUN	NN	Number=Sing	_	_	_	_
4	sequence	sequence	NOUN	NN	Number=Sing	_	_	_	_
5	competed	compet	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
6	for	for	ADP	IN	_	_	_	_	_
7	META	META	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
8	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
9	D	D	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
10	+	+	SYM	SYM	_	_	_	_	SpaceAfter=No
11	)	)	PUNCT	-RRB-	_	_	_	_	_
12	binding	binding	VERB	VBG	VerbForm=Ger	_	_	_	_
13	factors	factor	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
14	,	,	PUNCT	,	_	_	_	_	_
15	but	but	CCONJ	CC	_	_	_	_	_
16	META	META	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
17	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
18	D	D	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
19	+	+	SYM	SYM	_	_	_	_	SpaceAfter=No
20	)	)	PUNCT	-RRB-	_	_	_	_	_
21	failed	fail	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
22	to	to	PART	TO	_	_	_	_	_
23	compete	compete	VERB	VB	VerbForm=Inf	_	_	_	_
24	for	for	ADP	IN	_	_	_	_	_
25	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
26	complexes	complexe	NOUN	NNS	Number=Plur	_	_	_	_
27	obtained	obtaine	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
28	with	with	ADP	IN	_	_	_	_	_
29	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
30	SV40	SV40	PROPN	NNP	Number=Sing	_	_	_	_
31	probe	probe	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
32	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 518
# text = Our results, taken together, indicate that META(D+) is a novel transcriptional enhancer element that is similar in its cell-type specificity, activation dependence, and CsA sensitivity to the NFAT element.
1	Our	we	PRON	PRP$	Number=Plur|Person=1|Poss=Yes|PronType=Prs	_	_	_	_
2	results	result	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
3	,	,	PUNCT	,	_	_	_	_	_
4	taken	take	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
5	together	together	ADV	RB	_	_	_	_	SpaceAfter=No
6	,	,	PUNCT	,	_	_	_	_	_
7	indicate	indicate	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
8	that	that	SCONJ	IN	_	_	_	_	_
9	META	META	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
10	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
11	D	d	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
12	+	+	SYM	SYM	_	_	_	_	SpaceAfter=No
13	)	)	PUNCT	-RRB-	_	_	_	_	_
14	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
15	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
16	novel	novel	NOUN	NN	Number=Sing	_	_	_	_
17	transcriptional	transcriptional	ADJ	JJ	Degree=Pos	_	_	_	_
18	enhancer	enhancer	NOUN	NN	Number=Sing	_	_	_	_
19	element	element	NOUN	NN	Number=Sing	_	_	_	_
20	that	that	PRON	WDT	PronType=Rel	_	_	_	_
21	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
22	similar	similar	ADJ	JJ	Degree=Pos	_	_	_	_
23	in	in	SCONJ	IN	_	_	_	_	_
24	it	it	PRON	PRP	Case=Nom|Gender=Neut|Number=Sing|Person=3|PronType=Prs	_	_	_	SpaceAfter=No
25	s	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
26	cell	cell	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
27	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
28	type	type	NOUN	NN	Number=Sing	_	_	_	_
29	specificity	specificity	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
30	,	,	PUNCT	,	_	_	_	_	_
31	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
32	dependence	dependence	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
33	,	,	PUNCT	,	_	_	_	_	_
34	and	and	CCONJ	CC	_	_	_	_	_
35	CsA	csa	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
36	sensitivity	sensitivity	NOUN	NN	Number=Sing	_	_	_	_
37	to	to	ADP	IN	_	_	_	_	_
38	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
39	NFAT	NFAT	PROPN	NNP	Number=Sing	_	_	_	_
40	element	element	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
41	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 519
# text = It may be relevant to the role of MMTV in expression of Mls antigens or the induction of T cell lymphomas.
1	It	it	PRON	PRP	Case=Nom|Gender=Neut|Number=Sing|Person=3|PronType=Prs	_	_	_	_
2	may	may	AUX	MD	VerbForm=Fin	_	_	_	_
3	be	be	AUX	VB	VerbForm=Inf	_	_	_	_
4	relevant	relevant	ADJ	JJ	Degree=Pos	_	_	_	_
5	to	to	ADP	IN	_	_	_	_	_
6	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
7	role	role	NOUN	NN	Number=Sing	_	_	_	_
8	of	of	ADP	IN	_	_	_	_	_
9	MMTV	MMTV	PROPN	NNP	Number=Sing	_	_	_	_
10	in	in	ADP	IN	_	_	_	_	_
11	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
12	of	of	ADP	IN	_	_	_	_	_
13	Mls	Mls	NOUN	NNS	Number=Plur	_	_	_	_
14	antigens	antigen	NOUN	NNS	Number=Plur	_	_	_	_
15	or	or	CCONJ	CC	_	_	_	_	_
16	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
17	induction	induction	NOUN	NN	Number=Sing	_	_	_	_
18	of	of	ADP	IN	_	_	_	_	_
19	T	t	PROPN	NNP	Number=Sing	_	_	_	_
20	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
21	lymphomas	lymphoma	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
22	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 520
# text = Document 003002185 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	003002185	003002185	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 521
# text = Cytomegalovirus immediate early genes upregulate interleukin-6 gene expression.
1	Cytomegalovirus	Cytomegalovirus	PROPN	NNP	Number=Sing	_	_	_	_
2	immediate	immediate	ADJ	JJ	Degree=Pos	_	_	_	_
3	early	early	ADJ	JJ	Degree=Pos	_	_	_	_
4	genes	gene	NOUN	NNS	Number=Plur	_	_	_	_
5	upregulate	upregulate	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
6	interleukin	interleukin	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
7	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
8	6	6	NUM	CD	NumType=Card	_	_	_	_
9	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
10	expression	expression	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
11	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 522
# text = BACKGROUND: The immediate early genes (IE) of human cytomegalovirus (CMV) can be expressed in monocytic cells and are known to regulate viral and cellular genes.
1	BACKGROUND	background	ADP	IN	_	_	_	_	SpaceAfter=No
2	:	:	PUNCT	:	_	_	_	_	_
3	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
4	immediate	immediate	ADJ	JJ	Degree=Pos	_	_	_	_
5	early	early	ADJ	JJ	Degree=Pos	_	_	_	_
6	genes	gene	NOUN	NNS	Number=Plur	_	_	_	_
7	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
8	IE	ie	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
9	)	)	PUNCT	-RRB-	_	_	_	_	_
10	of	of	ADP	IN	_	_	_	_	_
11	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
12	cytomegalovirus	cytomegalovirus	NOUN	NN	Number=Sing	_	_	_	_
13	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
14	CMV	CMV	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
15	)	)	PUNCT	-RRB-	_	_	_	_	_
16	can	can	AUX	MD	VerbForm=Fin	_	_	_	_
17	be	be	AUX	VB	VerbForm=Inf	_	_	_	_
18	expressed	express	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
19	in	in	ADP	IN	_	_	_	_	_
20	monocytic	monocytic	ADJ	JJ	Degree=Pos	_	_	_	_
21	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
22	and	and	CCONJ	CC	_	_	_	_	_
23	are	be	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
24	known	know	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
25	to	to	PART	TO	_	_	_	_	_
26	regulate	regulate	VERB	VB	VerbForm=Inf	_	_	_	_
27	viral	viral	ADJ	JJ	Degree=Pos	_	_	_	_
28	and	and	CCONJ	CC	_	_	_	_	_
29	cellular	cellular	ADJ	JJ	Degree=Pos	_	_	_	_
30	genes	gene	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
31	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 523
# text = Interleukin-6 (IL-6) plays a central role in numerous inflammatory and immune processes.
1	Interleukin	Interleukin	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
2	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
3	6	6	NUM	CD	NumType=Card	_	_	_	_
4	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
5	IL	Il	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
6	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
7	6	6	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
8	)	)	PUNCT	-RRB-	_	_	_	_	_
9	plays	play	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
10	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
11	central	central	ADJ	JJ	Degree=Pos	_	_	_	_
12	role	role	NOUN	NN	Number=Sing	_	_	_	_
13	in	in	ADP	IN	_	_	_	_	_
14	numerous	numerous	ADJ	JJ	Degree=Pos	_	_	_	_
15	inflammatory	inflammatory	ADJ	JJ	Degree=Pos	_	_	_	_
16	and	and	CCONJ	CC	_	_	_	_	_
17	immune	immune	ADJ	JJ	Degree=Pos	_	_	_	_
18	processes	process	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
19	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 524
# text = Interleukin-6 levels are increased in lung transplant patients clinically diagnosed with CMV pneumonitis.
1	Interleukin	Interleukin	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
2	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
3	6	6	NUM	CD	NumType=Card	_	_	_	_
4	levels	level	NOUN	NNS	Number=Plur	_	_	_	_
5	are	be	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
6	increased	increase	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
7	in	in	ADP	IN	_	_	_	_	_
8	lung	lung	NOUN	NN	Number=Sing	_	_	_	_
9	transplant	transplant	NOUN	NN	Number=Sing	_	_	_	_
10	patients	patient	NOUN	NNS	Number=Plur	_	_	_	_
11	clinically	clinically	ADV	RB	_	_	_	_	_
12	diagnosed	diagnose	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
13	with	with	ADP	IN	_	_	_	_	_
14	CMV	Cmv	PROPN	NNP	Number=Sing	_	_	_	_
15	pneumonitis	pneumonitis	PROPN	NNPS	Number=Plur	_	_	_	SpaceAfter=No
16	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 525
# text = The regulation of IL-6 is dependent on various stimuli that include lipopolysaccharide (LPS), viruses, and other cytokines.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	regulation	regulation	NOUN	NN	Number=Sing	_	_	_	_
3	of	of	ADP	IN	_	_	_	_	_
4	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
5	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
6	6	6	NUM	CD	NumType=Card	_	_	_	_
7	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
8	dependent	dependent	ADJ	JJ	Degree=Pos	_	_	_	_
9	on	on	ADP	IN	_	_	_	_	_
10	various	various	ADJ	JJ	Degree=Pos	_	_	_	_
11	stimuli	stimuli	NOUN	NNS	Number=Plur	_	_	_	_
12	that	that	PRON	WDT	PronType=Rel	_	_	_	_
13	include	include	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
14	lipopolysaccharide	lipopolysaccharide	NOUN	NN	Number=Sing	_	_	_	_
15	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
16	LPS	Lp	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
17	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
18	,	,	PUNCT	,	_	_	_	_	_
19	viruses	viruse	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
20	,	,	PUNCT	,	_	_	_	_	_
21	and	and	CCONJ	CC	_	_	_	_	_
22	other	other	ADJ	JJ	Degree=Pos	_	_	_	_
23	cytokines	cytokine	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
24	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 526
# text = These studies examined the ability of CMV IE gene products to modulate IL-6 production.
1	These	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
2	studies	study	NOUN	NNS	Number=Plur	_	_	_	_
3	examined	examin	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
4	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
5	ability	ability	NOUN	NN	Number=Sing	_	_	_	_
6	of	of	ADP	IN	_	_	_	_	_
7	CMV	CMV	PROPN	NNP	Number=Sing	_	_	_	_
8	IE	ie	PROPN	NNP	Number=Sing	_	_	_	_
9	gene	gene	ADJ	JJ	Degree=Pos	_	_	_	_
10	products	product	NOUN	NNS	Number=Plur	_	_	_	_
11	to	to	PART	TO	_	_	_	_	_
12	modulate	modulate	VERB	VB	VerbForm=Inf	_	_	_	_
13	IL	Il	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
14	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
15	6	6	NUM	CD	NumType=Card	_	_	_	_
16	production	production	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
17	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 527
# text = METHODS: THP-1 cells, a monocytic cell line, were transfected with the CMV IE genes.
1	METHODS	method	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
2	:	:	PUNCT	:	_	_	_	_	_
3	THP	Thp	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
4	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
5	1	1	NUM	CD	NumType=Card	_	_	_	_
6	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
7	,	,	PUNCT	,	_	_	_	_	_
8	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
9	monocytic	monocytic	ADJ	JJ	Degree=Pos	_	_	_	_
10	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
11	line	line	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
12	,	,	PUNCT	,	_	_	_	_	_
13	were	be	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
14	transfected	transfect	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
15	with	with	ADP	IN	_	_	_	_	_
16	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
17	CMV	CMV	PROPN	NNP	Number=Sing	_	_	_	_
18	IE	ie	PROPN	NNP	Number=Sing	_	_	_	_
19	genes	gene	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
20	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 528
# text = Interleukin-6 protein and IL-6 mRNA were measured in control and CMV immediate early transfected cells.
1	Interleukin	Interleukin	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
2	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
3	6	6	NUM	CD	NumType=Card	_	_	_	_
4	protein	protein	NOUN	NN	Number=Sing	_	_	_	_
5	and	and	CCONJ	CC	_	_	_	_	_
6	IL	Il	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
7	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
8	6	6	NUM	CD	NumType=Card	_	_	_	_
9	mRNA	mRNa	NOUN	NN	Number=Sing	_	_	_	_
10	were	be	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
11	measured	measure	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
12	in	in	ADP	IN	_	_	_	_	_
13	control	control	NOUN	NN	Number=Sing	_	_	_	_
14	and	and	CCONJ	CC	_	_	_	_	_
15	CMV	Cmv	X	GW	_	_	_	_	_
16	immediate	immediate	ADJ	JJ	Degree=Pos	_	_	_	_
17	early	early	ADV	RB	Degree=Pos	_	_	_	_
18	transfected	transfect	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
19	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
20	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 529
# text = Cotransfection of CMV IE genes and IL-6 chloramphenicol acetyl transferase (CAT) or IL-6 luciferase constructs were used to study IL-6 promoter activity.
1	Cotransfection	Cotransfection	NOUN	NN	Number=Sing	_	_	_	_
2	of	of	ADP	IN	_	_	_	_	_
3	CMV	CMV	PROPN	NNP	Number=Sing	_	_	_	_
4	IE	ie	PROPN	NNP	Number=Sing	_	_	_	_
5	genes	gene	NOUN	NNS	Number=Plur	_	_	_	_
6	and	and	CCONJ	CC	_	_	_	_	_
7	IL	Il	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
8	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
9	6	6	NUM	CD	NumType=Card	_	_	_	_
10	chloramphenicol	chloramphenicol	NOUN	NN	Number=Sing	_	_	_	_
11	acetyl	acetyl	NOUN	NN	Number=Sing	_	_	_	_
12	transferase	transferase	NOUN	NN	Number=Sing	_	_	_	_
13	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
14	CAT	Cat	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
15	)	)	PUNCT	-RRB-	_	_	_	_	_
16	or	or	CCONJ	CC	_	_	_	_	_
17	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
18	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
19	6	6	NUM	CD	NumType=Card	_	_	_	_
20	luciferase	luciferase	NOUN	NN	Number=Sing	_	_	_	_
21	constructs	construct	NOUN	NNS	Number=Plur	_	_	_	_
22	were	be	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
23	used	use	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
24	to	to	PART	TO	_	_	_	_	_
25	study	study	VERB	VB	VerbForm=Inf	_	_	_	_
26	IL	Il	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
27	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
28	6	6	NUM	CD	NumType=Card	_	_	_	_
29	promoter	promoter	NOUN	NN	Number=Sing	_	_	_	_
30	activity	activity	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
31	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 530
# text = RESULTS: Interleukin-6 protein and mRNA production were significantly increased in cells transfected with the CMV IE genes and stimulated with LPS compared to LPS-stimulated control cells.
1	RESULTS	result	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
2	:	:	PUNCT	:	_	_	_	_	_
3	Interleukin	Interleukin	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
4	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
5	6	6	NUM	CD	NumType=Card	_	_	_	_
6	protein	protein	NOUN	NN	Number=Sing	_	_	_	_
7	and	and	CCONJ	CC	_	_	_	_	_
8	mRNA	mRNa	NOUN	NN	Number=Sing	_	_	_	_
9	production	production	NOUN	NN	Number=Sing	_	_	_	_
10	were	be	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
11	significantly	significantly	ADV	RB	_	_	_	_	_
12	increased	increase	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
13	in	in	ADP	IN	_	_	_	_	_
14	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
15	transfected	transfect	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
16	with	with	ADP	IN	_	_	_	_	_
17	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
18	CMV	CMV	PROPN	NNP	Number=Sing	_	_	_	_
19	IE	ie	PROPN	NNP	Number=Sing	_	_	_	_
20	genes	gene	NOUN	NNS	Number=Plur	_	_	_	_
21	and	and	CCONJ	CC	_	_	_	_	_
22	stimulated	stimulate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
23	with	with	ADP	IN	_	_	_	_	_
24	LPS	Lp	PROPN	NNP	Number=Sing	_	_	_	_
25	compared	compare	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
26	to	to	ADP	IN	_	_	_	_	_
27	LPS	LPS	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
28	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
29	stimulated	stimulate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
30	control	control	NOUN	NN	Number=Sing	_	_	_	_
31	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
32	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 531
# text = Cytomegalovirus
1	Cytomegalovirus	Cytomegalovirus	PROPN	NNP	Number=Sing	_	_	_	_

# sent_id = 532
# text = IE gene products significantly enhanced LPS stimulation of IL-6 promoter activity in both IL-6 CAT and IL-6 luciferase assays.
1	IE	ie	ADJ	JJ	Degree=Pos	_	_	_	_
2	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
3	products	product	NOUN	NNS	Number=Plur	_	_	_	_
4	significantly	significantly	ADV	RB	_	_	_	_	_
5	enhanced	enhance	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
6	LPS	Lps	ADJ	JJ	Degree=Pos	_	_	_	_
7	stimulation	stimulation	NOUN	NN	Number=Sing	_	_	_	_
8	of	of	ADP	IN	_	_	_	_	_
9	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
10	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
11	6	6	NUM	CD	NumType=Card	_	_	_	_
12	promoter	promoter	NOUN	NN	Number=Sing	_	_	_	_
13	activity	activity	NOUN	NN	Number=Sing	_	_	_	_
14	in	in	ADP	IN	_	_	_	_	_
15	both	both	DET	DT	_	_	_	_	_
16	IL	Il	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
17	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
18	6	6	NUM	CD	NumType=Card	_	_	_	_
19	CAT	cat	NOUN	NN	Number=Sing	_	_	_	_
20	and	and	CCONJ	CC	_	_	_	_	_
21	IL	Il	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
22	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
23	6	6	NUM	CD	NumType=Card	_	_	_	_
24	luciferase	luciferase	NOUN	NN	Number=Sing	_	_	_	_
25	assays	assay	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
26	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 533
# text = A deletion construct that contains a NF-kappa B site but is missing the multiple response region demonstrated a continued increase in IL-6 luciferase activity in LPS-stimulated CMV transfected cells.
1	A	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
2	deletion	deletion	NOUN	NN	Number=Sing	_	_	_	_
3	construct	construct	NOUN	NN	Number=Sing	_	_	_	_
4	that	that	PRON	WDT	PronType=Rel	_	_	_	_
5	contains	contain	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
6	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
7	NF	Nf	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
8	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
9	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_
10	B	b	NOUN	NN	Number=Sing	_	_	_	_
11	site	site	NOUN	NN	Number=Sing	_	_	_	_
12	but	but	CCONJ	CC	_	_	_	_	_
13	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
14	missing	miss	VERB	VBG	Tense=Pres|VerbForm=Part	_	_	_	_
15	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
16	multiple	multiple	ADJ	JJ	Degree=Pos	_	_	_	_
17	response	response	NOUN	NN	Number=Sing	_	_	_	_
18	region	region	NOUN	NN	Number=Sing	_	_	_	_
19	demonstrated	demonstrate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
20	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
21	continued	continu	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
22	increase	increase	NOUN	NN	Number=Sing	_	_	_	_
23	in	in	ADP	IN	_	_	_	_	_
24	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
25	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
26	6	6	NUM	CD	NumType=Card	_	_	_	_
27	luciferase	luciferase	NOUN	NN	Number=Sing	_	_	_	_
28	activity	activity	NOUN	NN	Number=Sing	_	_	_	_
29	in	in	ADP	IN	_	_	_	_	_
30	LPS	LPS	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
31	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
32	stimulated	stimulate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
33	CMV	haCmve	NOUN	NN	Number=Sing	_	_	_	_
34	transfected	transfect	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
35	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
36	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 534
# text = CONCLUSION: Cytomegalovirus immediate early gene products significantly enhanced expression of IL-6 in LPS-stimulated cells.
1	CONCLUSION	conclusion	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
2	:	:	PUNCT	:	_	_	_	_	_
3	Cytomegalovirus	Cytomegalovirus	PROPN	NNP	Number=Sing	_	_	_	_
4	immediate	immediate	ADJ	JJ	Degree=Pos	_	_	_	_
5	early	early	ADJ	JJ	Degree=Pos	_	_	_	_
6	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
7	products	product	NOUN	NNS	Number=Plur	_	_	_	_
8	significantly	significantly	ADV	RB	_	_	_	_	_
9	enhanced	enhance	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
10	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
11	of	of	ADP	IN	_	_	_	_	_
12	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
13	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
14	6	6	NUM	CD	NumType=Card	_	_	_	_
15	in	in	ADP	IN	_	_	_	_	_
16	LPS	LPS	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
17	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
18	stimulated	stimulate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
19	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
20	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 535
# text = The increase in IL-6 luciferase activity occurs in the absence of the multiple response region, the area of the IL-6 promoter responsive to IL-1, TNF alpha, cyclic amp, and phorbol 12-myristate 13-acetate.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	increase	increase	NOUN	NN	Number=Sing	_	_	_	_
3	in	in	ADP	IN	_	_	_	_	_
4	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
5	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
6	6	6	NUM	CD	NumType=Card	_	_	_	_
7	luciferase	luciferase	NOUN	NN	Number=Sing	_	_	_	_
8	activity	activity	NOUN	NN	Number=Sing	_	_	_	_
9	occurs	occur	NOUN	NNS	Number=Plur	_	_	_	_
10	in	in	ADP	IN	_	_	_	_	_
11	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
12	absence	absence	NOUN	NN	Number=Sing	_	_	_	_
13	of	of	ADP	IN	_	_	_	_	_
14	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
15	multiple	multiple	ADJ	JJ	Degree=Pos	_	_	_	_
16	response	response	NOUN	NN	Number=Sing	_	_	_	_
17	region	region	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
18	,	,	PUNCT	,	_	_	_	_	_
19	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
20	area	area	NOUN	NN	Number=Sing	_	_	_	_
21	of	of	ADP	IN	_	_	_	_	_
22	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
23	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
24	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
25	6	6	NUM	CD	NumType=Card	_	_	_	_
26	promoter	promoter	NOUN	NN	Number=Sing	_	_	_	_
27	responsive	responsive	ADJ	JJ	Degree=Pos	_	_	_	_
28	to	to	ADP	IN	_	_	_	_	_
29	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
30	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
31	1	1	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
32	,	,	PUNCT	,	_	_	_	_	_
33	TNF	TNF	PROPN	NNP	Number=Sing	_	_	_	_
34	alpha	alpha	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
35	,	,	PUNCT	,	_	_	_	_	_
36	cyclic	cyclic	ADJ	JJ	Degree=Pos	_	_	_	_
37	amp	amp	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
38	,	,	PUNCT	,	_	_	_	_	_
39	and	and	CCONJ	CC	_	_	_	_	_
40	phorbol	phorbol	NOUN	NN	Number=Sing	_	_	_	_
41	12	12	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
42	-	-	PUNCT	:	_	_	_	_	SpaceAfter=No
43	myristate	myristate	NOUN	NN	Number=Sing	_	_	_	_
44	13	13	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
45	-	-	PUNCT	:	_	_	_	_	SpaceAfter=No
46	acetate	acetate	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
47	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 536
# text = The ability of CMV IE gene products to enhance IL-6 production may play an important role in immune inflammatory states associated with CMV infection.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	ability	ability	NOUN	NN	Number=Sing	_	_	_	_
3	of	of	ADP	IN	_	_	_	_	_
4	CMV	CMV	PROPN	NNP	Number=Sing	_	_	_	_
5	IE	ie	PROPN	NNP	Number=Sing	_	_	_	_
6	gene	gene	ADJ	JJ	Degree=Pos	_	_	_	_
7	products	product	NOUN	NNS	Number=Plur	_	_	_	_
8	to	to	PART	TO	_	_	_	_	_
9	enhance	enhance	VERB	VB	VerbForm=Inf	_	_	_	_
10	IL	Il	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
11	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
12	6	6	NUM	CD	NumType=Card	_	_	_	_
13	production	production	NOUN	NN	Number=Sing	_	_	_	_
14	may	may	AUX	MD	VerbForm=Fin	_	_	_	_
15	play	play	VERB	VB	VerbForm=Inf	_	_	_	_
16	an	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
17	important	important	ADJ	JJ	Degree=Pos	_	_	_	_
18	role	role	NOUN	NN	Number=Sing	_	_	_	_
19	in	in	ADP	IN	_	_	_	_	_
20	immune	immune	ADJ	JJ	Degree=Pos	_	_	_	_
21	inflammatory	inflammatory	ADJ	JJ	Degree=Pos	_	_	_	_
22	states	state	NOUN	NNS	Number=Plur	_	_	_	_
23	associated	associate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
24	with	with	ADP	IN	_	_	_	_	_
25	CMV	Cmv	NOUN	NN	Number=Sing	_	_	_	_
26	infection	infection	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
27	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 537
# text = Document 003002187 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	003002187	003002187	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 538
# text = Costimulation requirement for AP-1 and NF-kappa B transcription factor activation in T cells.
1	Costimulation	Costimulation	NOUN	NN	Number=Sing	_	_	_	_
2	requirement	requirement	NOUN	NN	Number=Sing	_	_	_	_
3	for	for	ADP	IN	_	_	_	_	_
4	AP	Ap	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
5	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
6	1	1	NUM	CD	NumType=Card	_	_	_	_
7	and	and	CCONJ	CC	_	_	_	_	_
8	NF	Nf	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
9	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
10	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_
11	B	b	NOUN	NN	Number=Sing	_	_	_	_
12	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
13	factor	factor	NOUN	NN	Number=Sing	_	_	_	_
14	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
15	in	in	ADP	IN	_	_	_	_	_
16	T	t	PROPN	NNP	Number=Sing	_	_	_	_
17	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
18	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 539
# text = The transcriptional activity of the IL-2 promoter requires T-cell costimulation delivered by the TCR and the auxiliary receptor CD28.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	transcriptional	transcriptional	ADJ	JJ	Degree=Pos	_	_	_	_
3	activity	activity	NOUN	NN	Number=Sing	_	_	_	_
4	of	of	ADP	IN	_	_	_	_	_
5	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
6	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
7	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
8	2	2	NUM	CD	NumType=Card	_	_	_	_
9	promoter	promoter	NOUN	NN	Number=Sing	_	_	_	_
10	requires	require	NOUN	NNS	Number=Plur	_	_	_	_
11	T-	T-	PUNCT	:	_	_	_	_	SpaceAfter=No
12	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
13	costimulation	costimulation	NOUN	NN	Number=Sing	_	_	_	_
14	delivered	deliver	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
15	by	by	ADP	IN	_	_	_	_	_
16	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
17	TCR	Tcr	NOUN	NN	Number=Sing	_	_	_	_
18	and	and	CCONJ	CC	_	_	_	_	_
19	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
20	auxiliary	auxiliary	ADJ	JJ	Degree=Pos	_	_	_	_
21	receptor	receptor	NOUN	NN	Number=Sing	_	_	_	_
22	CD28	Cd28	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
23	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 540
# text = Several transcription factors participate in IL-2 promoter activation, among which are AP-1-like factors and NF-kappa B. Protein phosphorylation has an important role in the regulation of these two factors: (1) it induces the transactivating capacity of the AP-1 protein c-Jun; and (2) it is involved in the release of the cytoplasmic inhibitor, I kappa B, from NF-kappa B, allowing translocation of the latter into the nucleus.
1	Several	several	ADJ	JJ	Degree=Pos	_	_	_	_
2	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
3	factors	factor	NOUN	NNS	Number=Plur	_	_	_	_
4	participate	participate	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
5	in	in	ADP	IN	_	_	_	_	_
6	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
7	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
8	2	2	NUM	CD	NumType=Card	_	_	_	_
9	promoter	promoter	NOUN	NN	Number=Sing	_	_	_	_
10	activation	activation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
11	,	,	PUNCT	,	_	_	_	_	_
12	among	among	ADP	IN	_	_	_	_	_
13	which	which	PRON	WDT	PronType=Rel	_	_	_	_
14	are	be	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
15	AP	ap	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
16	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
17	1	1	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
18	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
19	like	like	ADP	IN	_	_	_	_	_
20	factors	factor	NOUN	NNS	Number=Plur	_	_	_	_
21	and	and	CCONJ	CC	_	_	_	_	_
22	NF	Nf	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
23	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
24	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_
25	B	b	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
26	.	.	PUNCT	.	_	_	_	_	_
27	Protein	protein	NOUN	NN	Number=Sing	_	_	_	_
28	phosphorylation	phosphorylation	NOUN	NN	Number=Sing	_	_	_	_
29	has	have	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
30	an	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
31	important	important	ADJ	JJ	Degree=Pos	_	_	_	_
32	role	role	NOUN	NN	Number=Sing	_	_	_	_
33	in	in	ADP	IN	_	_	_	_	_
34	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
35	regulation	regulation	NOUN	NN	Number=Sing	_	_	_	_
36	of	of	ADP	IN	_	_	_	_	_
37	these	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
38	two	two	NUM	CD	NumType=Card	_	_	_	_
39	factors	factor	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
40	:	:	PUNCT	:	_	_	_	_	_
41	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
42	1	1	X	LS	_	_	_	_	SpaceAfter=No
43	)	)	PUNCT	-RRB-	_	_	_	_	_
44	it	it	PRON	PRP	Case=Nom|Gender=Neut|Number=Sing|Person=3|PronType=Prs	_	_	_	_
45	induces	induce	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
46	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
47	transactivating	transactivat	VERB	VBG	VerbForm=Ger	_	_	_	_
48	capacity	capacity	NOUN	NN	Number=Sing	_	_	_	_
49	of	of	ADP	IN	_	_	_	_	_
50	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
51	AP	ap	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
52	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
53	1	1	NUM	CD	NumType=Card	_	_	_	_
54	protein	protein	NOUN	NN	Number=Sing	_	_	_	_
55	c	c	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
56	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
57	Jun	Jun	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
58	;	;	PUNCT	,	_	_	_	_	_
59	and	and	CCONJ	CC	_	_	_	_	_
60	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
61	2	2	X	LS	_	_	_	_	SpaceAfter=No
62	)	)	PUNCT	-RRB-	_	_	_	_	_
63	it	it	PRON	PRP	Case=Nom|Gender=Neut|Number=Sing|Person=3|PronType=Prs	_	_	_	_
64	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
65	involved	involved	ADJ	JJ	Degree=Pos	_	_	_	_
66	in	in	ADP	IN	_	_	_	_	_
67	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
68	release	release	NOUN	NN	Number=Sing	_	_	_	_
69	of	of	ADP	IN	_	_	_	_	_
70	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
71	cytoplasmic	cytoplasmic	ADJ	JJ	Degree=Pos	_	_	_	_
72	inhibitor	inhibitor	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
73	,	,	PUNCT	,	_	_	_	_	_
74	I	I	PRON	PRP	Case=Nom|Number=Sing|Person=1|PronType=Prs	_	_	_	_
75	kappa	kappa	PROPN	NNP	Number=Sing	_	_	_	_
76	B	B	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
77	,	,	PUNCT	,	_	_	_	_	_
78	from	from	ADP	IN	_	_	_	_	_
79	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
80	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
81	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_
82	B	b	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
83	,	,	PUNCT	,	_	_	_	_	_
84	allowing	allow	VERB	VBG	VerbForm=Ger	_	_	_	_
85	translocation	translocation	NOUN	NN	Number=Sing	_	_	_	_
86	of	of	ADP	IN	_	_	_	_	_
87	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
88	latter	latter	ADJ	JJ	Degree=Pos	_	_	_	_
89	into	into	ADP	IN	_	_	_	_	_
90	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
91	nucleus	nucleus	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
92	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 541
# text = We have recently shown that both phosphorylation processes require T-cell costimulation.
1	We	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
2	have	have	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
3	recently	recently	ADV	RB	_	_	_	_	_
4	shown	show	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
5	that	that	SCONJ	IN	_	_	_	_	_
6	both	both	DET	DT	_	_	_	_	_
7	phosphorylation	phosphorylation	NOUN	NN	Number=Sing	_	_	_	_
8	processes	process	NOUN	NNS	Number=Plur	_	_	_	_
9	require	require	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
10	T-	T-	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
11	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
12	costimulation	costimulation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
13	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 542
# text = Furthermore, in activated T cells, the kinetics of the two phosphorylation events are essentially similar.
1	Furthermore	furthermore	ADV	RB	_	_	_	_	SpaceAfter=No
2	,	,	PUNCT	,	_	_	_	_	_
3	in	in	ADP	IN	_	_	_	_	_
4	activated	activate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
5	T	t	PROPN	NNP	Number=Sing	_	_	_	_
6	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
7	,	,	PUNCT	,	_	_	_	_	_
8	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
9	kinetics	kinetic	NOUN	NNS	Number=Plur	_	_	_	_
10	of	of	ADP	IN	_	_	_	_	_
11	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
12	two	two	NUM	CD	NumType=Card	_	_	_	_
13	phosphorylation	phosphorylation	NOUN	NN	Number=Sing	_	_	_	_
14	events	event	NOUN	NNS	Number=Plur	_	_	_	_
15	are	be	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
16	essentially	essentially	ADV	RB	_	_	_	_	_
17	similar	similar	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
18	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 543
# text = According to our results, however, the kinases responsible for the two processes are distinct entities.
1	According	accord	VERB	VBG	VerbForm=Ger	_	_	_	_
2	to	to	ADP	IN	_	_	_	_	_
3	our	we	PRON	PRP$	Number=Plur|Person=1|Poss=Yes|PronType=Prs	_	_	_	_
4	results	result	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
5	,	,	PUNCT	,	_	_	_	_	_
6	however	however	ADV	RB	_	_	_	_	SpaceAfter=No
7	,	,	PUNCT	,	_	_	_	_	_
8	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
9	kinases	kinase	NOUN	NNS	Number=Plur	_	_	_	_
10	responsible	responsible	ADJ	JJ	Degree=Pos	_	_	_	_
11	for	for	ADP	IN	_	_	_	_	_
12	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
13	two	two	NUM	CD	NumType=Card	_	_	_	_
14	processes	process	NOUN	NNS	Number=Plur	_	_	_	_
15	are	be	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
16	distinct	distinct	ADJ	JJ	Degree=Pos	_	_	_	_
17	entities	entity	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
18	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 544
# text = Whereas TPCK inhibits phosphorylation of I kappa B and, consequently, activation of NF-kappa B, it markedly enhances the activity of JNK, the MAP kinase-related kinase that phosphorylates the transactivation domain of c-Jun.
1	Whereas	whereas	SCONJ	IN	_	_	_	_	_
2	TPCK	TPCK	PROPN	NNP	Number=Sing	_	_	_	_
3	inhibits	inhibits	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
4	phosphorylation	phosphorylation	NOUN	NN	Number=Sing	_	_	_	_
5	of	of	ADP	IN	_	_	_	_	_
6	I	I	PRON	PRP	Case=Nom|Number=Sing|Person=1|PronType=Prs	_	_	_	_
7	kappa	kappa	PROPN	NNP	Number=Sing	_	_	_	_
8	B	B	PROPN	NNP	Number=Sing	_	_	_	_
9	and	and	CCONJ	CC	_	_	_	_	SpaceAfter=No
10	,	,	PUNCT	,	_	_	_	_	_
11	consequently	consequently	ADV	RB	_	_	_	_	SpaceAfter=No
12	,	,	PUNCT	,	_	_	_	_	_
13	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
14	of	of	ADP	IN	_	_	_	_	_
15	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
16	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
17	kappa	kappa	PROPN	NNP	Number=Sing	_	_	_	_
18	B	B	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
19	,	,	PUNCT	,	_	_	_	_	_
20	it	it	PRON	PRP	Case=Nom|Gender=Neut|Number=Sing|Person=3|PronType=Prs	_	_	_	_
21	markedly	markedly	ADV	RB	_	_	_	_	_
22	enhances	enhance	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
23	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
24	activity	activity	NOUN	NN	Number=Sing	_	_	_	_
25	of	of	ADP	IN	_	_	_	_	_
26	JNK	JNK	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
27	,	,	PUNCT	,	_	_	_	_	_
28	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
29	MAP	map	PROPN	NNP	Number=Sing	_	_	_	_
30	kinase	kinase	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
31	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
32	related	related	ADJ	JJ	Degree=Pos	_	_	_	_
33	kinase	kinase	NOUN	NN	Number=Sing	_	_	_	_
34	that	that	PRON	WDT	PronType=Rel	_	_	_	_
35	phosphorylates	phosphorylate	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
36	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
37	transactivation	transactivation	NOUN	NN	Number=Sing	_	_	_	_
38	domain	domain	NOUN	NN	Number=Sing	_	_	_	_
39	of	of	ADP	IN	_	_	_	_	_
40	c	c	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
41	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
42	Jun	Jun	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
43	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 545
# text = We, therefore, propose the activation scheme presented in FIGURE 3 for T-cell costimulation.
1	We	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	SpaceAfter=No
2	,	,	PUNCT	,	_	_	_	_	_
3	therefore	therefore	ADV	RB	_	_	_	_	SpaceAfter=No
4	,	,	PUNCT	,	_	_	_	_	_
5	propose	propose	VERB	VB	VerbForm=Inf	_	_	_	_
6	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
7	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
8	scheme	scheme	NOUN	NN	Number=Sing	_	_	_	_
9	presented	present	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
10	in	in	ADP	IN	_	_	_	_	_
11	FIGURE	figure	PROPN	NNP	Number=Sing	_	_	_	_
12	3	3	NUM	CD	NumType=Card	_	_	_	_
13	for	for	ADP	IN	_	_	_	_	_
14	T-	t-	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
15	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
16	costimulation	costimulation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
17	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 546
# text = Costimulation results in the activation of a signaling pathway that leads to the simultaneous induction of the two transcription factors, AP-1 and NF-kappa B.
1	Costimulation	Costimulation	NOUN	NN	Number=Sing	_	_	_	_
2	results	result	NOUN	NNS	Number=Plur	_	_	_	_
3	in	in	ADP	IN	_	_	_	_	_
4	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
5	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
6	of	of	ADP	IN	_	_	_	_	_
7	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
8	signaling	signal	NOUN	NN	Number=Sing	_	_	_	_
9	pathway	pathway	NOUN	NN	Number=Sing	_	_	_	_
10	that	that	PRON	WDT	PronType=Rel	_	_	_	_
11	leads	lead	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
12	to	to	ADP	IN	_	_	_	_	_
13	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
14	simultaneous	simultaneous	ADJ	JJ	Degree=Pos	_	_	_	_
15	induction	induction	NOUN	NN	Number=Sing	_	_	_	_
16	of	of	ADP	IN	_	_	_	_	_
17	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
18	two	two	NUM	CD	NumType=Card	_	_	_	_
19	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
20	factors	factor	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
21	,	,	PUNCT	,	_	_	_	_	_
22	AP	ap	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
23	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
24	1	1	NUM	CD	NumType=Card	_	_	_	_
25	and	and	CCONJ	CC	_	_	_	_	_
26	NF	Nf	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
27	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
28	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_
29	B	b	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
30	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 547
# text = Integration of the signals generated by TCR and CD28 engagement occurs along this pathway, which then bifurcates to induce I kappa B phosphorylation and NF-kappa B activation on the one hand, and JNK activation and c-Jun phosphorylation on the other.
1	Integration	Integration	NOUN	NN	Number=Sing	_	_	_	_
2	of	of	ADP	IN	_	_	_	_	_
3	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
4	signals	signal	NOUN	NNS	Number=Plur	_	_	_	_
5	generated	generate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
6	by	by	ADP	IN	_	_	_	_	_
7	TCR	TCR	PROPN	NNP	Number=Sing	_	_	_	_
8	and	and	CCONJ	CC	_	_	_	_	_
9	CD28	CD28	PROPN	NNP	Number=Sing	_	_	_	_
10	engagement	engagement	NOUN	NN	Number=Sing	_	_	_	_
11	occurs	occur	NOUN	NNS	Number=Plur	_	_	_	_
12	along	along	ADP	IN	_	_	_	_	_
13	this	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
14	pathway	pathway	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
15	,	,	PUNCT	,	_	_	_	_	_
16	which	which	PRON	WDT	PronType=Rel	_	_	_	_
17	then	then	ADV	RB	PronType=Dem	_	_	_	_
18	bifurcates	bifurcate	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
19	to	to	PART	TO	_	_	_	_	_
20	induce	induce	VERB	VB	VerbForm=Inf	_	_	_	_
21	I	I	PRON	PRP	Case=Nom|Number=Sing|Person=1|PronType=Prs	_	_	_	_
22	kappa	kappa	X	FW	Foreign=Yes	_	_	_	_
23	B	b	ADJ	JJ	Degree=Pos	_	_	_	_
24	phosphorylation	phosphorylation	NOUN	NN	Number=Sing	_	_	_	_
25	and	and	CCONJ	CC	_	_	_	_	_
26	NF	Nf	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
27	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
28	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_
29	B	b	NOUN	NN	Number=Sing	_	_	_	_
30	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
31	on	on	ADP	IN	_	_	_	_	_
32	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
33	one	one	NUM	CD	NumType=Card	_	_	_	_
34	hand	hand	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
35	,	,	PUNCT	,	_	_	_	_	_
36	and	and	CCONJ	CC	_	_	_	_	_
37	JNK	JNK	PROPN	NNP	Number=Sing	_	_	_	_
38	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
39	and	and	CCONJ	CC	_	_	_	_	_
40	c	c	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
41	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
42	Jun	Jun	PROPN	NNP	Number=Sing	_	_	_	_
43	phosphorylation	phosphorylation	NOUN	NN	Number=Sing	_	_	_	_
44	on	on	ADP	IN	_	_	_	_	_
45	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
46	other	other	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
47	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 548
# text = We are currently engaged in defining where the two signals integrate along the AP-1/NF-kappa B pathway.
1	We	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
2	are	be	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
3	currently	currently	ADV	RB	_	_	_	_	_
4	engaged	engage	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
5	in	in	SCONJ	IN	_	_	_	_	_
6	defining	define	VERB	VBG	VerbForm=Ger	_	_	_	_
7	where	where	ADV	WRB	PronType=Int	_	_	_	_
8	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
9	two	two	NUM	CD	NumType=Card	_	_	_	_
10	signals	signal	NOUN	NNS	Number=Plur	_	_	_	_
11	integrate	integrate	ADJ	JJ	Degree=Pos	_	_	_	_
12	along	along	ADP	IN	_	_	_	_	_
13	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
14	AP	ap	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
15	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
16	1/	1ith	ADP	IN	Abbr=Yes	_	_	_	SpaceAfter=No
17	NF	Nf	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
18	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
19	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_
20	B	b	NOUN	NN	Number=Sing	_	_	_	_
21	pathway	pathway	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
22	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 549
# text = Document 003002190 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	003002190	003002190	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 550
# text = The Epstein-Barr virus oncogene product latent membrane protein 1 engages the tumor necrosis factor receptor-associated death domain protein to mediate B lymphocyte growth transformation and activate NF-kappaB.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	Epstein	Epstein	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
3	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
4	Barr	Barr	PROPN	NNP	Number=Sing	_	_	_	_
5	virus	virus	NOUN	NN	Number=Sing	_	_	_	_
6	oncogene	oncogene	NOUN	NN	Number=Sing	_	_	_	_
7	product	product	NOUN	NN	Number=Sing	_	_	_	_
8	latent	latent	ADJ	JJ	Degree=Pos	_	_	_	_
9	membrane	membrane	NOUN	NN	Number=Sing	_	_	_	_
10	protein	protein	NOUN	NN	Number=Sing	_	_	_	_
11	1	1	NUM	CD	NumType=Card	_	_	_	_
12	engages	engage	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
13	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
14	tumor	tumor	NOUN	NN	Number=Sing	_	_	_	_
15	necrosis	necrosis	NOUN	NN	Number=Sing	_	_	_	_
16	factor	factor	NOUN	NN	Number=Sing	_	_	_	_
17	receptor	receptor	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
18	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
19	associated	associate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
20	death	death	NOUN	NN	Number=Sing	_	_	_	_
21	domain	domain	NOUN	NN	Number=Sing	_	_	_	_
22	protein	protein	NOUN	NN	Number=Sing	_	_	_	_
23	to	to	PART	TO	_	_	_	_	_
24	mediate	mediate	VERB	VB	VerbForm=Inf	_	_	_	_
25	B	b	NOUN	NN	Number=Sing	_	_	_	_
26	lymphocyte	lymphocyte	NOUN	NN	Number=Sing	_	_	_	_
27	growth	growth	NOUN	NN	Number=Sing	_	_	_	_
28	transformation	transformation	NOUN	NN	Number=Sing	_	_	_	_
29	and	and	CCONJ	CC	_	_	_	_	_
30	activate	activate	VERB	VB	VerbForm=Inf	_	_	_	_
31	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
32	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
33	kappaB	kappaB	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
34	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 551
# text = The Epstein-Barr virus latent membrane protein 1 (LMP1) is essential for the transformation of B lymphocytes into lymphoblastoid cell lines.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	Epstein	Epstein	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
3	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
4	Barr	Barr	PROPN	NNP	Number=Sing	_	_	_	_
5	virus	virus	NOUN	NN	Number=Sing	_	_	_	_
6	latent	latent	ADJ	JJ	Degree=Pos	_	_	_	_
7	membrane	membrane	NOUN	NN	Number=Sing	_	_	_	_
8	protein	protein	NOUN	NN	Number=Sing	_	_	_	_
9	1	1	NUM	CD	NumType=Card	_	_	_	_
10	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
11	LMP1	Lmp1	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
12	)	)	PUNCT	-RRB-	_	_	_	_	_
13	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
14	essential	essential	ADJ	JJ	Degree=Pos	_	_	_	_
15	for	for	ADP	IN	_	_	_	_	_
16	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
17	transformation	transformation	NOUN	NN	Number=Sing	_	_	_	_
18	of	of	ADP	IN	_	_	_	_	_
19	B	b	ADJ	JJ	Degree=Pos	_	_	_	_
20	lymphocytes	lymphocyte	NOUN	NNS	Number=Plur	_	_	_	_
21	into	into	ADP	IN	_	_	_	_	_
22	lymphoblastoid	lymphoblastoid	ADJ	JJ	Degree=Pos	_	_	_	_
23	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
24	lines	line	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
25	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 552
# text = Previous data are consistent with a model that LMP1 is a constitutively activated receptor that transduces signals for transformation through its carboxyl-terminal cytoplasmic tail.
1	Previous	previous	ADJ	JJ	Degree=Pos	_	_	_	_
2	data	data	NOUN	NN	Number=Sing	_	_	_	_
3	are	be	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
4	consistent	consistent	ADJ	JJ	Degree=Pos	_	_	_	_
5	with	with	ADP	IN	_	_	_	_	_
6	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
7	model	model	NOUN	NN	Number=Sing	_	_	_	_
8	that	that	PRON	WDT	PronType=Rel	_	_	_	_
9	LMP1	LMP1	PROPN	NNP	Number=Sing	_	_	_	_
10	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
11	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
12	constitutively	constitutively	ADV	RB	_	_	_	_	_
13	activated	activate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
14	receptor	receptor	NOUN	NN	Number=Sing	_	_	_	_
15	that	that	PRON	WDT	PronType=Rel	_	_	_	_
16	transduces	transduce	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
17	signals	signal	NOUN	NNS	Number=Plur	_	_	_	_
18	for	for	ADP	IN	_	_	_	_	_
19	transformation	transformation	NOUN	NN	Number=Sing	_	_	_	_
20	through	through	ADP	IN	_	_	_	_	_
21	its	its	PRON	PRP$	Gender=Neut|Number=Sing|Person=3|Poss=Yes|PronType=Prs	_	_	_	_
22	carboxyl	carboxyl	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
23	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
24	terminal	terminal	ADJ	JJ	Degree=Pos	_	_	_	_
25	cytoplasmic	cytoplasmic	ADJ	JJ	Degree=Pos	_	_	_	_
26	tail	tail	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
27	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 553
# text = One transformation effector site (TES1), located within the membrane proximal 45 residues of the cytoplasmic tail, constitutively engages tumor necrosis factor receptor-associated factors.
1	One	one	NUM	CD	NumType=Card	_	_	_	_
2	transformation	transformation	NOUN	NN	Number=Sing	_	_	_	_
3	effector	effector	NOUN	NN	Number=Sing	_	_	_	_
4	site	site	NOUN	NN	Number=Sing	_	_	_	_
5	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
6	TES1	TES1	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
7	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
8	,	,	PUNCT	,	_	_	_	_	_
9	located	locate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
10	within	within	ADP	IN	_	_	_	_	_
11	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
12	membrane	membrane	NOUN	NN	Number=Sing	_	_	_	_
13	proximal	proximal	NOUN	NN	Number=Sing	_	_	_	_
14	45	45	NUM	CD	NumType=Card	_	_	_	_
15	residues	residue	NOUN	NNS	Number=Plur	_	_	_	_
16	of	of	ADP	IN	_	_	_	_	_
17	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
18	cytoplasmic	cytoplasmic	ADJ	JJ	Degree=Pos	_	_	_	_
19	tail	tail	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
20	,	,	PUNCT	,	_	_	_	_	_
21	constitutively	constitutively	ADV	RB	_	_	_	_	_
22	engages	engage	NOUN	NNS	Number=Plur	_	_	_	_
23	tumor	tumor	ADP	IN	_	_	_	_	_
24	necrosis	necrosis	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
25	factor	factor	NOUN	NN	Number=Sing	_	_	_	_
26	receptor	receptor	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
27	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
28	associated	associate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
29	factors	factor	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
30	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 554
# text = Signals from TES1 are sufficient to drive initial proliferation of infected resting B lymphocytes, but most lymphoblastoid cells infected with a virus that does not express the 155 residues beyond TES1 fail to grow as long-term cell lines.
1	Signals	signal	NOUN	NNS	Number=Plur	_	_	_	_
2	from	from	ADP	IN	_	_	_	_	_
3	TES1	tES1	NOUN	NN	Number=Sing	_	_	_	_
4	are	be	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
5	sufficient	sufficient	ADJ	JJ	Degree=Pos	_	_	_	_
6	to	to	PART	TO	_	_	_	_	_
7	drive	drive	VERB	VB	VerbForm=Inf	_	_	_	_
8	initial	initial	ADJ	JJ	Degree=Pos	_	_	_	_
9	proliferation	proliferation	NOUN	NN	Number=Sing	_	_	_	_
10	of	of	ADP	IN	_	_	_	_	_
11	infected	infect	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
12	resting	reste	VERB	VBG	VerbForm=Ger	_	_	_	_
13	B	b	NOUN	NN	Number=Sing	_	_	_	_
14	lymphocytes	lymphocyte	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
15	,	,	PUNCT	,	_	_	_	_	_
16	but	but	CCONJ	CC	_	_	_	_	_
17	most	most	ADV	RBS	_	_	_	_	_
18	lymphoblastoid	lymphoblastoid	ADJ	JJ	Degree=Pos	_	_	_	_
19	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
20	infected	infect	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
21	with	with	ADP	IN	_	_	_	_	_
22	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
23	virus	virus	NOUN	NN	Number=Sing	_	_	_	_
24	that	that	PRON	WDT	PronType=Rel	_	_	_	_
25	does	do	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
26	not	not	PART	RB	_	_	_	_	_
27	express	express	VERB	VB	VerbForm=Inf	_	_	_	_
28	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
29	155	155	NUM	CD	NumType=Card	_	_	_	_
30	residues	residue	NOUN	NNS	Number=Plur	_	_	_	_
31	beyond	beyond	ADP	IN	_	_	_	_	_
32	TES1	TES1	NUM	CD	NumType=Card	_	_	_	_
33	fail	fail	NOUN	NN	Number=Sing	_	_	_	_
34	to	to	PART	TO	_	_	_	_	_
35	grow	grow	VERB	VB	VerbForm=Inf	_	_	_	_
36	as	as	ADP	IN	_	_	_	_	_
37	long	long	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
38	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
39	term	term	NOUN	NN	Number=Sing	_	_	_	_
40	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
41	lines	line	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
42	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 555
# text = We now find that mutating two tyrosines to an isoleucine at the carboxyl end of the cytoplasmic tail cripples the ability of EBV to cause lymphoblastoid cell outgrowth, thereby marking a second transformation effector site, TES2.
1	We	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
2	now	now	ADV	RB	_	_	_	_	_
3	find	find	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
4	that	that	SCONJ	IN	_	_	_	_	_
5	mutating	mutat	VERB	VBG	VerbForm=Ger	_	_	_	_
6	two	two	NUM	CD	NumType=Card	_	_	_	_
7	tyrosines	tyrosine	NOUN	NNS	Number=Plur	_	_	_	_
8	to	to	ADP	IN	_	_	_	_	_
9	an	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
10	isoleucine	isoleucine	NOUN	NN	Number=Sing	_	_	_	_
11	at	at	ADP	IN	_	_	_	_	_
12	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
13	carboxyl	carboxyl	NOUN	NN	Number=Sing	_	_	_	_
14	end	end	NOUN	NN	Number=Sing	_	_	_	_
15	of	of	ADP	IN	_	_	_	_	_
16	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
17	cytoplasmic	cytoplasmic	ADJ	JJ	Degree=Pos	_	_	_	_
18	tail	tail	NOUN	NN	Number=Sing	_	_	_	_
19	cripples	cripple	NOUN	NNS	Number=Plur	_	_	_	_
20	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
21	ability	ability	NOUN	NN	Number=Sing	_	_	_	_
22	of	of	ADP	IN	_	_	_	_	_
23	EBV	EBV	PROPN	NNP	Number=Sing	_	_	_	_
24	to	to	PART	TO	_	_	_	_	_
25	cause	cause	VERB	VB	VerbForm=Inf	_	_	_	_
26	lymphoblastoid	lymphoblastoid	NOUN	NN	Number=Sing	_	_	_	_
27	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
28	outgrowth	outgrowth	ADV	RB	_	_	_	_	SpaceAfter=No
29	,	,	PUNCT	,	_	_	_	_	_
30	thereby	thereby	ADV	RB	_	_	_	_	_
31	marking	mark	VERB	VBG	VerbForm=Ger	_	_	_	_
32	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
33	second	second	ADJ	JJ	Degree=Pos|NumType=Ord	_	_	_	_
34	transformation	transformation	NOUN	NN	Number=Sing	_	_	_	_
35	effector	effector	NOUN	NN	Number=Sing	_	_	_	_
36	site	site	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
37	,	,	PUNCT	,	_	_	_	_	_
38	TES2	TES2	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
39	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 556
# text = A yeast two-hybrid screen identified TES2 interacting proteins, including the tumor necrosis factor receptor-associated death domain protein (TRADD).
1	A	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
2	yeast	yeast	ADJ	JJS	Degree=Sup	_	_	_	_
3	two	two	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
4	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
5	hybrid	hybrid	NOUN	NN	Number=Sing	_	_	_	_
6	screen	screen	NOUN	NN	Number=Sing	_	_	_	_
7	identified	identify	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
8	TES2	TES2	NUM	CD	NumType=Card	_	_	_	_
9	interacting	interact	VERB	VBG	VerbForm=Ger	_	_	_	_
10	proteins	protein	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
11	,	,	PUNCT	,	_	_	_	_	_
12	including	include	VERB	VBG	VerbForm=Ger	_	_	_	_
13	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
14	tumor	tumor	NOUN	NN	Number=Sing	_	_	_	_
15	necrosis	necrosis	NOUN	NN	Number=Sing	_	_	_	_
16	factor	factor	NOUN	NN	Number=Sing	_	_	_	_
17	receptor	receptor	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
18	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
19	associated	associate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
20	death	death	NOUN	NN	Number=Sing	_	_	_	_
21	domain	domain	NOUN	NN	Number=Sing	_	_	_	_
22	protein	protein	NOUN	NN	Number=Sing	_	_	_	_
23	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
24	TRADD	TRADD	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
25	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
26	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 557
# text = TRADD was the only protein that interacted with wild-type TES2 and not with isoleucine-mutated TES2.
1	TRADD	tRADd	NOUN	NN	Number=Sing	_	_	_	_
2	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
3	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
4	only	only	ADJ	JJ	Degree=Pos	_	_	_	_
5	protein	protein	NOUN	NN	Number=Sing	_	_	_	_
6	that	that	PRON	WDT	PronType=Rel	_	_	_	_
7	interacted	interact	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
8	with	with	ADP	IN	_	_	_	_	_
9	wild	wild	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
10	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
11	type	type	NOUN	NN	Number=Sing	_	_	_	_
12	TES2	Tes2	NOUN	NN	Number=Sing	_	_	_	_
13	and	and	CCONJ	CC	_	_	_	_	_
14	not	not	ADV	RB	_	_	_	_	_
15	with	with	ADP	IN	_	_	_	_	_
16	isoleucine	isoleucine	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
17	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
18	mutated	mutate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
19	TES2	Tes2	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
20	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 558
# text = TRADD associated with wild-type LMP1 but not with isoleucine-mutated LMP1 in mammalian cells, and TRADD constitutively associated with LMP1 in EBV-transformed cells.
1	TRADD	Tradd	NOUN	NN	Number=Sing	_	_	_	_
2	associated	associate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
3	with	with	ADP	IN	_	_	_	_	_
4	wild	wild	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
5	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
6	type	type	NOUN	NN	Number=Sing	_	_	_	_
7	LMP1	Lmp1	NOUN	NN	Number=Sing	_	_	_	_
8	but	but	CCONJ	CC	_	_	_	_	_
9	not	not	PART	RB	_	_	_	_	_
10	with	with	ADP	IN	_	_	_	_	_
11	isoleucine-mutated	isoleucine-mutate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
12	LMP1	Lmp1	NOUN	NN	Number=Sing	_	_	_	_
13	in	in	ADP	IN	_	_	_	_	_
14	mammalian	mammalian	ADJ	JJ	Degree=Pos	_	_	_	_
15	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
16	,	,	PUNCT	,	_	_	_	_	_
17	and	and	CCONJ	CC	_	_	_	_	_
18	TRADD	TRADD	PROPN	NNP	Number=Sing	_	_	_	_
19	constitutively	constitutively	ADV	RB	_	_	_	_	_
20	associated	associate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
21	with	with	ADP	IN	_	_	_	_	_
22	LMP1	LMP1	PROPN	NNP	Number=Sing	_	_	_	_
23	in	in	ADP	IN	_	_	_	_	_
24	EBV	EBV	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
25	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
26	transformed	transform	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
27	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
28	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 559
# text = In transfection assays, TRADD and TES2 synergistically mediated high-level NF-kappaB activation.
1	In	in	ADP	IN	_	_	_	_	_
2	transfection	transfection	NOUN	NN	Number=Sing	_	_	_	_
3	assays	assay	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	,	,	PUNCT	,	_	_	_	_	_
5	TRADD	Tradd	PROPN	NNP	Number=Sing	_	_	_	_
6	and	and	CCONJ	CC	_	_	_	_	_
7	TES2	TES2	NUM	CD	NumType=Card	_	_	_	_
8	synergistically	synergistically	ADV	RB	_	_	_	_	_
9	mediated	mediate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
10	high	high	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
11	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
12	level	level	NOUN	NN	Number=Sing	_	_	_	_
13	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
14	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
15	kappaB	kappaB	PROPN	NNP	Number=Sing	_	_	_	_
16	activation	activation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
17	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 560
# text = These results indicate that LMP1 appropriates TRADD to enable efficient long-term lymphoblastoid cell outgrowth.
1	These	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
2	results	result	NOUN	NNS	Number=Plur	_	_	_	_
3	indicate	indicate	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
4	that	that	SCONJ	IN	_	_	_	_	_
5	LMP1	LMP1	PROPN	NNP	Number=Sing	_	_	_	_
6	appropriates	appropriate	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
7	TRADD	TRADD	PROPN	NNP	Number=Sing	_	_	_	_
8	to	to	PART	TO	_	_	_	_	_
9	enable	enable	VERB	VB	VerbForm=Inf	_	_	_	_
10	efficient	efficient	ADJ	JJ	Degree=Pos	_	_	_	_
11	long	long	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
12	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
13	term	term	NOUN	NN	Number=Sing	_	_	_	_
14	lymphoblastoid	lymphoblastoid	NOUN	NN	Number=Sing	_	_	_	_
15	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
16	outgrowth	outgrowth	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
17	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 561
# text = High-level NF-kappaB activation also appears to be a critical component of long-term outgrowth.
1	High	high	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
2	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
3	level	level	NOUN	NN	Number=Sing	_	_	_	_
4	NF	Nf	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
5	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
6	kappaB	kappab	PROPN	NNP	Number=Sing	_	_	_	_
7	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
8	also	also	ADV	RB	_	_	_	_	_
9	appears	appear	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
10	to	to	PART	TO	_	_	_	_	_
11	be	be	AUX	VB	VerbForm=Inf	_	_	_	_
12	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
13	critical	critical	ADJ	JJ	Degree=Pos	_	_	_	_
14	component	component	NOUN	NN	Number=Sing	_	_	_	_
15	of	of	ADP	IN	_	_	_	_	_
16	long	long	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
17	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
18	term	term	NOUN	NN	Number=Sing	_	_	_	_
19	outgrowth	outgrowth	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
20	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 562
# text = Document 003002194 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	003002194	003002194	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 563
# text = Antisense oligonucleotides to the p65 subunit of NF-kappa B block CD11b expression and alter adhesion properties of differentiated HL-60 granulocytes.
1	Antisense	Antisense	ADJ	JJ	Degree=Pos	_	_	_	_
2	oligonucleotides	oligonucleotide	NOUN	NNS	Number=Plur	_	_	_	_
3	to	to	ADP	IN	_	_	_	_	_
4	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
5	p65	p65	NOUN	NN	Number=Sing	_	_	_	_
6	subunit	subunit	NOUN	NN	Number=Sing	_	_	_	_
7	of	of	ADP	IN	_	_	_	_	_
8	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
9	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
10	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_
11	B	b	NOUN	NN	Number=Sing	_	_	_	_
12	block	block	NOUN	NN	Number=Sing	_	_	_	_
13	CD	cd	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
14	11	11	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
15	b	b	NOUN	NN	Number=Sing	_	_	_	_
16	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
17	and	and	CCONJ	CC	_	_	_	_	_
18	alter	alter	NOUN	NN	Number=Sing	_	_	_	_
19	adhesion	adhesion	NOUN	NN	Number=Sing	_	_	_	_
20	properties	property	NOUN	NNS	Number=Plur	_	_	_	_
21	of	of	ADP	IN	_	_	_	_	_
22	differentiated	differentiate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
23	HL	HL	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
24	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
25	60	60	NUM	CD	NumType=Card	_	_	_	_
26	granulocytes	granulocyte	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
27	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 564
# text = NF-kappa B is a pleiotropic regulator of a variety of genes implicated in the cellular response to injury.
1	NF	Nf	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
2	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
3	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_
4	B	b	NOUN	NN	Number=Sing	_	_	_	_
5	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
6	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
7	pleiotropic	pleiotropic	ADJ	JJ	Degree=Pos	_	_	_	_
8	regulator	regulator	NOUN	NN	Number=Sing	_	_	_	_
9	of	of	ADP	IN	_	_	_	_	_
10	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
11	variety	variety	NOUN	NN	Number=Sing	_	_	_	_
12	of	of	ADP	IN	_	_	_	_	_
13	genes	gene	NOUN	NNS	Number=Plur	_	_	_	_
14	implicated	implicate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
15	in	in	ADP	IN	_	_	_	_	_
16	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
17	cellular	cellular	ADJ	JJ	Degree=Pos	_	_	_	_
18	response	response	NOUN	NN	Number=Sing	_	_	_	_
19	to	to	ADP	IN	_	_	_	_	_
20	injury	injury	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
21	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 565
# text = This function has been attributed to the coordinated binding of subunits of NF-kappa B to distinct regions of the promoter elements of numerous genes, including cytokines, growth factor receptors, and adhesion molecules.
1	This	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
2	function	function	NOUN	NN	Number=Sing	_	_	_	_
3	has	have	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
4	been	be	AUX	VBN	Tense=Past|VerbForm=Part	_	_	_	_
5	attributed	attribute	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
6	to	to	ADP	IN	_	_	_	_	_
7	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
8	coordinated	coordinate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
9	binding	binding	NOUN	NN	Number=Sing	_	_	_	_
10	of	of	ADP	IN	_	_	_	_	_
11	subunits	subunit	NOUN	NNS	Number=Plur	_	_	_	_
12	of	of	ADP	IN	_	_	_	_	_
13	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
14	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
15	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_
16	B	b	NOUN	NN	Number=Sing	_	_	_	_
17	to	to	ADP	IN	_	_	_	_	_
18	distinct	distinct	ADJ	JJ	Degree=Pos	_	_	_	_
19	regions	region	NOUN	NNS	Number=Plur	_	_	_	_
20	of	of	ADP	IN	_	_	_	_	_
21	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
22	promoter	promoter	NOUN	NN	Number=Sing	_	_	_	_
23	elements	element	NOUN	NNS	Number=Plur	_	_	_	_
24	of	of	ADP	IN	_	_	_	_	_
25	numerous	numerous	ADJ	JJ	Degree=Pos	_	_	_	_
26	genes	gene	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
27	,	,	PUNCT	,	_	_	_	_	_
28	including	include	VERB	VBG	VerbForm=Ger	_	_	_	_
29	cytokines	cytokine	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
30	,	,	PUNCT	,	_	_	_	_	_
31	growth	growth	NOUN	NN	Number=Sing	_	_	_	_
32	factor	factor	NOUN	NN	Number=Sing	_	_	_	_
33	receptors	receptor	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
34	,	,	PUNCT	,	_	_	_	_	_
35	and	and	CCONJ	CC	_	_	_	_	_
36	adhesion	adhesion	NOUN	NN	Number=Sing	_	_	_	_
37	molecules	molecule	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
38	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 566
# text = Antisense phosphorothioate oligonucleotides to the p50 and p65 subunits of the NF-kappa B complex were used to define the physiologic role of this transcription factor in resting and stimulated granulocytes.
1	Antisense	Antisense	ADJ	JJ	Degree=Pos	_	_	_	_
2	phosphorothioate	phosphorothioate	NOUN	NN	Number=Sing	_	_	_	_
3	oligonucleotides	oligonucleotide	NOUN	NNS	Number=Plur	_	_	_	_
4	to	to	ADP	IN	_	_	_	_	_
5	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
6	p50	p50	NOUN	NN	Number=Sing	_	_	_	_
7	and	and	CCONJ	CC	_	_	_	_	_
8	p65	p65	NUM	CD	NumType=Card	_	_	_	_
9	subunits	subunit	NOUN	NNS	Number=Plur	_	_	_	_
10	of	of	ADP	IN	_	_	_	_	_
11	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
12	NF	Nf	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
13	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
14	kappa	kappa	PROPN	NNP	Number=Sing	_	_	_	_
15	B	b	PROPN	NNP	Number=Sing	_	_	_	_
16	complex	complex	NOUN	NN	Number=Sing	_	_	_	_
17	were	be	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
18	used	use	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
19	to	to	PART	TO	_	_	_	_	_
20	define	define	VERB	VB	VerbForm=Inf	_	_	_	_
21	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
22	physiologic	physiologic	NOUN	NN	Number=Sing	_	_	_	_
23	role	role	NOUN	NN	Number=Sing	_	_	_	_
24	of	of	ADP	IN	_	_	_	_	_
25	this	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
26	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
27	factor	factor	NOUN	NN	Number=Sing	_	_	_	_
28	in	in	SCONJ	IN	_	_	_	_	_
29	resting	reste	VERB	VBG	VerbForm=Ger	_	_	_	_
30	and	and	CCONJ	CC	_	_	_	_	_
31	stimulated	stimulate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
32	granulocytes	granulocyte	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
33	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 567
# text = A reduction in the expression of p65 was produced by treatment with the phosphorothioate antisense oligodeoxynucleotide.
1	A	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
2	reduction	reduction	NOUN	NN	Number=Sing	_	_	_	_
3	in	in	ADP	IN	_	_	_	_	_
4	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
5	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
6	of	of	ADP	IN	_	_	_	_	_
7	p65	p65	NOUN	NN	Number=Sing	_	_	_	_
8	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
9	produced	produce	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
10	by	by	ADP	IN	_	_	_	_	_
11	treatment	treatment	NOUN	NN	Number=Sing	_	_	_	_
12	with	with	ADP	IN	_	_	_	_	_
13	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
14	phosphorothioate	phosphorothioate	NOUN	NN	Number=Sing	_	_	_	_
15	antisense	antisense	NOUN	NN	Number=Sing	_	_	_	_
16	oligodeoxynucleotide	oligodeoxynucleotide	ADV	RB	_	_	_	_	SpaceAfter=No
17	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 568
# text = This reduction was accompanied by rapid changes in the cellular adhesion of dimethyl sulfoxide-differentiated HL-60 leukemia cells stimulated by 12-O-tetradecanoylphorbol 13-acetate (TPA).
1	This	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
2	reduction	reduction	NOUN	NN	Number=Sing	_	_	_	_
3	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
4	accompanied	accompany	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
5	by	by	ADP	IN	_	_	_	_	_
6	rapid	rapid	ADJ	JJ	Degree=Pos	_	_	_	_
7	changes	change	NOUN	NNS	Number=Plur	_	_	_	_
8	in	in	ADP	IN	_	_	_	_	_
9	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
10	cellular	cellular	ADJ	JJ	Degree=Pos	_	_	_	_
11	adhesion	adhesion	NOUN	NN	Number=Sing	_	_	_	_
12	of	of	ADP	IN	_	_	_	_	_
13	dimethyl	dimethyl	NOUN	NN	Number=Sing	_	_	_	_
14	sulfoxide	sulfoxide	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
15	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
16	differentiated	differentiate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
17	HL	Hl	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
18	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
19	60	60	NUM	CD	NumType=Card	_	_	_	_
20	leukemia	leukemia	NOUN	NN	Number=Sing	_	_	_	_
21	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
22	stimulated	stimulate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
23	by	by	ADP	IN	_	_	_	_	_
24	12	12	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
25	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
26	O	of	ADP	IN	Abbr=Yes	_	_	_	SpaceAfter=No
27	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
28	tetradecanoylphorbol	tetradecanoylphorbol	NOUN	NN	Number=Sing	_	_	_	_
29	13	13	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
30	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
31	acetate	acetate	NOUN	NN	Number=Sing	_	_	_	_
32	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
33	TPA	TPA	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
34	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
35	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 569
# text = These effects were characterized by a marked reduction in CD11b integrin expression on the surface of treated cells.
1	These	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
2	effects	effect	NOUN	NNS	Number=Plur	_	_	_	_
3	were	be	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
4	characterized	characterize	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
5	by	by	ADP	IN	_	_	_	_	_
6	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
7	marked	mark	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
8	reduction	reduction	NOUN	NN	Number=Sing	_	_	_	_
9	in	in	ADP	IN	_	_	_	_	_
10	CD	cd	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
11	11	11	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
12	b	benefit	NOUN	NN	Number=Sing	_	_	_	_
13	integrin	integrin	ADP	IN	_	_	_	_	_
14	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
15	on	on	ADP	IN	_	_	_	_	_
16	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
17	surface	surface	NOUN	NN	Number=Sing	_	_	_	_
18	of	of	ADP	IN	_	_	_	_	_
19	treated	treat	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
20	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
21	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 570
# text = Furthermore, the p65 antisense oligomer effectively abolished an upregulation of CD11b that was produced by formyl-met-leu-phe and TPA.
1	Furthermore	furthermore	ADV	RB	_	_	_	_	SpaceAfter=No
2	,	,	PUNCT	,	_	_	_	_	_
3	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
4	p65	p65	NOUN	NN	Number=Sing	_	_	_	_
5	antisense	antisense	NOUN	NN	Number=Sing	_	_	_	_
6	oligomer	oligomer	NOUN	NN	Number=Sing	_	_	_	_
7	effectively	effectively	ADV	RB	_	_	_	_	_
8	abolished	abolish	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
9	an	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
10	upregulation	upregulation	NOUN	NN	Number=Sing	_	_	_	_
11	of	of	ADP	IN	_	_	_	_	_
12	CD	cd	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
13	11	11	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
14	b	b	NOUN	NN	Number=Sing	_	_	_	_
15	that	that	PRON	WDT	PronType=Rel	_	_	_	_
16	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
17	produced	produce	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
18	by	by	ADP	IN	_	_	_	_	_
19	formyl	formyl	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
20	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
21	met	meet	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	SpaceAfter=No
22	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
23	leu	leu	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
24	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
25	phe	phe	NOUN	NN	Number=Sing	_	_	_	_
26	and	and	CCONJ	CC	_	_	_	_	_
27	TPA	TPa	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
28	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 571
# text = However, the p65 antisense phosphorothioate oligodeoxynucleotide had no significant effect on the production of reactive oxygen intermediates or on phagocytosis by these cells.
1	However	however	ADV	RB	_	_	_	_	SpaceAfter=No
2	,	,	PUNCT	,	_	_	_	_	_
3	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
4	p65	p65	NOUN	NN	Number=Sing	_	_	_	_
5	antisense	antisense	NOUN	NN	Number=Sing	_	_	_	_
6	phosphorothioate	phosphorothioate	NOUN	NN	Number=Sing	_	_	_	_
7	oligodeoxynucleotide	oligodeoxynucleotide	ADV	RB	_	_	_	_	_
8	had	have	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
9	no	no	DET	DT	_	_	_	_	_
10	significant	significant	ADJ	JJ	Degree=Pos	_	_	_	_
11	effect	effect	NOUN	NN	Number=Sing	_	_	_	_
12	on	on	ADP	IN	_	_	_	_	_
13	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
14	production	production	NOUN	NN	Number=Sing	_	_	_	_
15	of	of	ADP	IN	_	_	_	_	_
16	reactive	reactive	ADJ	JJ	Degree=Pos	_	_	_	_
17	oxygen	oxygen	NOUN	NN	Number=Sing	_	_	_	_
18	intermediates	intermediate	NOUN	NNS	Number=Plur	_	_	_	_
19	or	or	CCONJ	CC	_	_	_	_	_
20	on	on	ADP	IN	_	_	_	_	_
21	phagocytosis	phagocytosis	NOUN	NN	Number=Sing	_	_	_	_
22	by	by	ADP	IN	_	_	_	_	_
23	these	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
24	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
25	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 572
# text = These findings indicate that antisense oligomers to p65 can be used to define the role of NF-kappa B in the activation pathways of neutrophils.
1	These	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
2	findings	finding	NOUN	NNS	Number=Plur	_	_	_	_
3	indicate	indicate	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
4	that	that	SCONJ	IN	_	_	_	_	_
5	antisense	antisense	ADJ	JJ	Degree=Pos	_	_	_	_
6	oligomers	oligomer	NOUN	NNS	Number=Plur	_	_	_	_
7	to	to	ADP	IN	_	_	_	_	_
8	p65	p65	NOUN	NN	Number=Sing	_	_	_	_
9	can	can	AUX	MD	VerbForm=Fin	_	_	_	_
10	be	be	AUX	VB	VerbForm=Inf	_	_	_	_
11	used	use	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
12	to	to	PART	TO	_	_	_	_	_
13	define	define	VERB	VB	VerbForm=Inf	_	_	_	_
14	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
15	role	role	NOUN	NN	Number=Sing	_	_	_	_
16	of	of	ADP	IN	_	_	_	_	_
17	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
18	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
19	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_
20	B	b	NOUN	NN	Number=Sing	_	_	_	_
21	in	in	ADP	IN	_	_	_	_	_
22	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
23	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
24	pathways	pathway	NOUN	NNS	Number=Plur	_	_	_	_
25	of	of	ADP	IN	_	_	_	_	_
26	neutrophils	neutrophil	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
27	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 573
# text = Document 003002196 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	003002196	003002196	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 574
# text = ETS transcription factors regulate an enhancer activity in the third intron of TNF-alpha.
1	ETS	ets	NOUN	NN	Number=Sing	_	_	_	_
2	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
3	factors	factor	NOUN	NNS	Number=Plur	_	_	_	_
4	regulate	regulate	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
5	an	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
6	enhancer	enhancer	NOUN	NN	Number=Sing	_	_	_	_
7	activity	activity	NOUN	NN	Number=Sing	_	_	_	_
8	in	in	ADP	IN	_	_	_	_	_
9	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
10	third	third	ADJ	JJ	Degree=Pos|NumType=Ord	_	_	_	_
11	intron	intron	NOUN	NN	Number=Sing	_	_	_	_
12	of	of	ADP	IN	_	_	_	_	_
13	TNF	TNF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
14	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
15	alpha	alpha	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
16	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 575
# text = We describe an enhancer site in the third intron of tumor necrosis factor alpha (TNF-alpha).
1	We	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
2	describe	describe	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
3	an	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
4	enhancer	enhancer	NOUN	NN	Number=Sing	_	_	_	_
5	site	site	NOUN	NN	Number=Sing	_	_	_	_
6	in	in	ADP	IN	_	_	_	_	_
7	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
8	third	third	ADJ	JJ	Degree=Pos|NumType=Ord	_	_	_	_
9	intron	intron	NOUN	NN	Number=Sing	_	_	_	_
10	of	of	ADP	IN	_	_	_	_	_
11	tumor	tumor	NOUN	NN	Number=Sing	_	_	_	_
12	necrosis	necrosis	NOUN	NN	Number=Sing	_	_	_	_
13	factor	factor	NOUN	NN	Number=Sing	_	_	_	_
14	alpha	alpha	NOUN	NN	Number=Sing	_	_	_	_
15	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
16	TNF	Tnf	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
17	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
18	alpha	alpha	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
19	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
20	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 576
# text = A reporter construct containing the 5'-flanking region of the mouse TNF-alpha gene displayed weak activity when transfected into RAW264.7 macrophage-like cells.
1	A	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
2	reporter	reporter	NOUN	NN	Number=Sing	_	_	_	_
3	construct	construct	NOUN	NN	Number=Sing	_	_	_	_
4	containing	contain	VERB	VBG	VerbForm=Ger	_	_	_	_
5	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
6	5	5	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
7	'	'	PUNCT	''	_	_	_	_	SpaceAfter=No
8	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
9	flanking	flank	VERB	VBG	VerbForm=Ger	_	_	_	_
10	region	region	NOUN	NN	Number=Sing	_	_	_	_
11	of	of	ADP	IN	_	_	_	_	_
12	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
13	mouse	mouse	NOUN	NN	Number=Sing	_	_	_	_
14	TNF	Tnf	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
15	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
16	alpha	alpha	NOUN	NN	Number=Sing	_	_	_	_
17	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
18	displayed	display	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
19	weak	weak	ADJ	JJ	Degree=Pos	_	_	_	_
20	activity	activity	NOUN	NN	Number=Sing	_	_	_	_
21	when	when	ADV	WRB	PronType=Int	_	_	_	_
22	transfected	transfect	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
23	into	into	ADP	IN	_	_	_	_	_
24	RAW	RAW	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
25	264.7	264.7	NUM	CD	NumType=Card	_	_	_	_
26	macrophage	macrophage	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
27	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
28	like	like	ADJ	JJ	Degree=Pos	_	_	_	_
29	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
30	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 577
# text = The addition of the third intron of TNF-alpha to this construct resulted in an enhancement of CAT protein.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	addition	addition	NOUN	NN	Number=Sing	_	_	_	_
3	of	of	ADP	IN	_	_	_	_	_
4	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
5	third	third	ADJ	JJ	Degree=Pos|NumType=Ord	_	_	_	_
6	intron	intron	NOUN	NN	Number=Sing	_	_	_	_
7	of	of	ADP	IN	_	_	_	_	_
8	TNF	TNF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
9	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
10	alpha	alpha	NOUN	NN	Number=Sing	_	_	_	_
11	to	to	ADP	IN	_	_	_	_	_
12	this	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
13	construct	construct	NOUN	NN	Number=Sing	_	_	_	_
14	resulted	result	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
15	in	in	ADP	IN	_	_	_	_	_
16	an	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
17	enhancement	enhancement	NOUN	NN	Number=Sing	_	_	_	_
18	of	of	ADP	IN	_	_	_	_	_
19	CAT	Cat	NOUN	NN	Number=Sing	_	_	_	_
20	protein	protein	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
21	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 578
# text = This enhancement was eliminated if a conserved 20-bp sequence was removed from the intron or if a dominant-negative ets-binding factor was co-transfected with the reporter gene.
1	This	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
2	enhancement	enhancement	NOUN	NN	Number=Sing	_	_	_	_
3	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
4	eliminated	eliminate	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
5	if	if	SCONJ	IN	_	_	_	_	_
6	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
7	conserved	conserve	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
8	20	20	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
9	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
10	bp	bp	NOUN	NN	Number=Sing	_	_	_	_
11	sequence	sequence	NOUN	NN	Number=Sing	_	_	_	_
12	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
13	removed	remove	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
14	from	from	ADP	IN	_	_	_	_	_
15	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
16	intron	intron	NOUN	NN	Number=Sing	_	_	_	_
17	or	or	CCONJ	CC	_	_	_	_	_
18	if	if	SCONJ	IN	_	_	_	_	_
19	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
20	dominant	dominant	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
21	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
22	negative	negative	ADJ	JJ	Degree=Pos	_	_	_	_
23	ets	et	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
24	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
25	binding	bind	VERB	VBG	VerbForm=Ger	_	_	_	_
26	factor	factor	NOUN	NN	Number=Sing	_	_	_	_
27	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
28	co-transfected	co-transfect	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
29	with	with	ADP	IN	_	_	_	_	_
30	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
31	reporter	reporter	NOUN	NN	Number=Sing	_	_	_	_
32	gene	gene	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
33	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 579
# text = Mutations of this site that destroyed potential ets transcription factor binding sites had reduced transcriptional activity.
1	Mutations	Mutation	NOUN	NNS	Number=Plur	_	_	_	_
2	of	of	ADP	IN	_	_	_	_	_
3	this	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
4	site	site	NOUN	NN	Number=Sing	_	_	_	_
5	that	that	PRON	WDT	PronType=Rel	_	_	_	_
6	destroyed	destroy	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
7	potential	potential	ADJ	JJ	Degree=Pos	_	_	_	_
8	ets	et	NOUN	NNS	Number=Plur	_	_	_	_
9	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
10	factor	factor	NOUN	NN	Number=Sing	_	_	_	_
11	binding	binding	VERB	VBG	VerbForm=Ger	_	_	_	_
12	sites	site	NOUN	NNS	Number=Plur	_	_	_	_
13	had	have	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
14	reduced	reduce	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
15	transcriptional	transcriptional	ADJ	JJ	Degree=Pos	_	_	_	_
16	activity	activity	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
17	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 580
# text = The major transcription factor that bound to the oligonucleotide was confirmed to be GABP by supershift and competition analysis.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	major	major	ADJ	JJ	Degree=Pos	_	_	_	_
3	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
4	factor	factor	NOUN	NN	Number=Sing	_	_	_	_
5	that	that	PRON	WDT	PronType=Rel	_	_	_	_
6	bound	bound	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
7	to	to	ADP	IN	_	_	_	_	_
8	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
9	oligonucleotide	oligonucleotide	NOUN	NN	Number=Sing	_	_	_	_
10	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
11	confirmed	confirm	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
12	to	to	PART	TO	_	_	_	_	_
13	be	be	AUX	VB	VerbForm=Inf	_	_	_	_
14	GABP	GABP	PROPN	NNP	Number=Sing	_	_	_	_
15	by	by	ADP	IN	_	_	_	_	_
16	supershift	supershift	NOUN	NN	Number=Sing	_	_	_	_
17	and	and	CCONJ	CC	_	_	_	_	_
18	competition	competition	NOUN	NN	Number=Sing	_	_	_	_
19	analysis	analysis	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
20	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 581
# text = In RAW264.7 cells, the binding was constitutive, however, in bone marrow-derived macrophages binding activity was shown to be interferon-gamma inducible.
1	In	in	ADP	IN	_	_	_	_	_
2	RAW	RAW	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
3	264.7	264.7	NUM	CD	NumType=Card	_	_	_	_
4	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
5	,	,	PUNCT	,	_	_	_	_	_
6	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
7	binding	binding	NOUN	NN	Number=Sing	_	_	_	_
8	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
9	constitutive	constitutive	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
10	,	,	PUNCT	,	_	_	_	_	_
11	however	however	ADV	RB	_	_	_	_	SpaceAfter=No
12	,	,	PUNCT	,	_	_	_	_	_
13	in	in	ADP	IN	_	_	_	_	_
14	bone	bone	ADJ	JJ	Degree=Pos	_	_	_	_
15	marrow	marrow	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
16	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
17	derived	derive	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
18	macrophages	macrophage	NOUN	NNS	Number=Plur	_	_	_	_
19	binding	bind	VERB	VBG	VerbForm=Ger	_	_	_	_
20	activity	activity	NOUN	NN	Number=Sing	_	_	_	_
21	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
22	shown	show	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
23	to	to	PART	TO	_	_	_	_	_
24	be	be	AUX	VB	VerbForm=Inf	_	_	_	_
25	interferon	interferon	ADP	IN	_	_	_	_	SpaceAfter=No
26	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
27	gamma	gamma	NOUN	NN	Number=Sing	_	_	_	_
28	inducible	inducible	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
29	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 582
# text = This may imply a role for ets transcription factors in the production of TNF-alpha.
1	This	this	PRON	DT	Number=Sing|PronType=Dem	_	_	_	_
2	may	may	AUX	MD	VerbForm=Fin	_	_	_	_
3	imply	imply	VERB	VB	VerbForm=Inf	_	_	_	_
4	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
5	role	role	NOUN	NN	Number=Sing	_	_	_	_
6	for	for	ADP	IN	_	_	_	_	_
7	ets	et	NOUN	NNS	Number=Plur	_	_	_	_
8	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
9	factors	factor	NOUN	NNS	Number=Plur	_	_	_	_
10	in	in	ADP	IN	_	_	_	_	_
11	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
12	production	production	NOUN	NN	Number=Sing	_	_	_	_
13	of	of	ADP	IN	_	_	_	_	_
14	TNF	TNF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
15	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
16	alpha	alpha	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
17	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 583
# text = Document 003002199 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	003002199	003002199	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 584
# text = Xenogeneic human serum promotes leukocyte adhesion to porcine endothelium under flow conditions, possibly through the activation of the transcription factor NF-kappa B.
1	Xenogeneic	Xenogeneic	ADJ	JJ	Degree=Pos	_	_	_	_
2	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
3	serum	serum	NOUN	NN	Number=Sing	_	_	_	_
4	promotes	promote	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
5	leukocyte	leukocyte	ADJ	JJ	Degree=Pos	_	_	_	_
6	adhesion	adhesion	NOUN	NN	Number=Sing	_	_	_	_
7	to	to	PART	TO	_	_	_	_	_
8	porcine	porcine	VERB	VB	VerbForm=Inf	_	_	_	_
9	endothelium	endothelium	NOUN	NN	Number=Sing	_	_	_	_
10	under	under	ADP	IN	_	_	_	_	_
11	flow	flow	NOUN	NN	Number=Sing	_	_	_	_
12	conditions	condition	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
13	,	,	PUNCT	,	_	_	_	_	_
14	possibly	possibly	ADV	RB	_	_	_	_	_
15	through	through	ADP	IN	_	_	_	_	_
16	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
17	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
18	of	of	ADP	IN	_	_	_	_	_
19	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
20	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
21	factor	factor	NOUN	NN	Number=Sing	_	_	_	_
22	NF	Nf	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
23	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
24	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_
25	B	b	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
26	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 585
# text = Endothelial cell activation and leukocyte infiltration are a consistent feature of discordant xenograft rejection.
1	Endothelial	Endothelial	ADJ	JJ	Degree=Pos	_	_	_	_
2	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
3	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
4	and	and	CCONJ	CC	_	_	_	_	_
5	leukocyte	leukocyte	NOUN	NN	Number=Sing	_	_	_	_
6	infiltration	infiltration	NOUN	NN	Number=Sing	_	_	_	_
7	are	be	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
8	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
9	consistent	consistent	ADJ	JJ	Degree=Pos	_	_	_	_
10	feature	feature	NOUN	NN	Number=Sing	_	_	_	_
11	of	of	ADP	IN	_	_	_	_	_
12	discordant	discordant	ADJ	JJ	Degree=Pos	_	_	_	_
13	xenograft	xenograft	NOUN	NN	Number=Sing	_	_	_	_
14	rejection	rejection	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
15	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 586
# text = Here we evaluated whether xenogeneic serum, as a source of xenoreactive natural antibodies and complement, induced endothelial cell activation with consequent leukocyte adhesion under flow conditions.
1	Here	here	ADV	RB	PronType=Dem	_	_	_	_
2	we	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
3	evaluated	evaluate	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
4	whether	whether	SCONJ	IN	_	_	_	_	_
5	xenogeneic	xenogeneic	ADJ	JJ	Degree=Pos	_	_	_	_
6	serum	serum	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
7	,	,	PUNCT	,	_	_	_	_	_
8	as	as	ADP	IN	_	_	_	_	_
9	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
10	source	source	NOUN	NN	Number=Sing	_	_	_	_
11	of	of	ADP	IN	_	_	_	_	_
12	xenoreactive	xenoreactive	ADJ	JJ	Degree=Pos	_	_	_	_
13	natural	natural	ADJ	JJ	Degree=Pos	_	_	_	_
14	antibodies	antibody	NOUN	NNS	Number=Plur	_	_	_	_
15	and	and	CCONJ	CC	_	_	_	_	_
16	complement	complement	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
17	,	,	PUNCT	,	_	_	_	_	_
18	induced	induce	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
19	endothelial	endothelial	ADJ	JJ	Degree=Pos	_	_	_	_
20	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
21	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
22	with	with	ADP	IN	_	_	_	_	_
23	consequent	consequent	ADJ	JJ	Degree=Pos	_	_	_	_
24	leukocyte	leukocyte	NOUN	NN	Number=Sing	_	_	_	_
25	adhesion	adhesion	NOUN	NN	Number=Sing	_	_	_	_
26	under	under	ADP	IN	_	_	_	_	_
27	flow	flow	ADJ	JJ	Degree=Pos	_	_	_	_
28	conditions	condition	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
29	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 587
# text = Porcine aortic endothelial cells (PAEC) were incubated for 1 hr 30 min or 5 hr with 10% homologous porcine serum (control) or 10% xenogeneic human serum and then perfused with total human leukocytes in a parallel plate flow chamber under laminar flow (1.5 dynes/cm2).
1	Porcine	Porcine	PROPN	NNP	Number=Sing	_	_	_	_
2	aortic	aortic	ADJ	JJ	Degree=Pos	_	_	_	_
3	endothelial	endothelial	ADJ	JJ	Degree=Pos	_	_	_	_
4	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
5	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
6	PAEC	PAEC	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
7	)	)	PUNCT	-RRB-	_	_	_	_	_
8	were	be	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
9	incubated	incubate	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
10	for	for	ADP	IN	_	_	_	_	_
11	1	1	NUM	CD	NumType=Card	_	_	_	_
12	hr	hr	NOUN	NN	Number=Sing	_	_	_	_
13	30	30	NUM	CD	NumType=Card	_	_	_	_
14	min	min	NOUN	NNS	Number=Plur	_	_	_	_
15	or	or	CCONJ	CC	_	_	_	_	_
16	5	5	NUM	CD	NumType=Card	_	_	_	_
17	hr	hr	NOUN	NN	Number=Sing	_	_	_	_
18	with	with	ADP	IN	_	_	_	_	_
19	10	10	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
20	%	%	SYM	NN	Number=Sing	_	_	_	_
21	homologous	homologous	ADJ	JJ	Degree=Pos	_	_	_	_
22	porcine	porcine	NOUN	NN	Number=Sing	_	_	_	_
23	serum	serum	NOUN	NN	Number=Sing	_	_	_	_
24	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
25	control	control	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
26	)	)	PUNCT	-RRB-	_	_	_	_	_
27	or	or	CCONJ	CC	_	_	_	_	_
28	10	10	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
29	%	%	SYM	NN	Number=Sing	_	_	_	_
30	xenogeneic	xenogeneic	ADJ	JJ	Degree=Pos	_	_	_	_
31	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
32	serum	serum	NOUN	NN	Number=Sing	_	_	_	_
33	and	and	CCONJ	CC	_	_	_	_	_
34	then	then	ADV	RB	PronType=Dem	_	_	_	_
35	perfused	perfuse	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
36	with	with	ADP	IN	_	_	_	_	_
37	total	total	ADJ	JJ	Degree=Pos	_	_	_	_
38	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
39	leukocytes	leukocyte	NOUN	NNS	Number=Plur	_	_	_	_
40	in	in	ADP	IN	_	_	_	_	_
41	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
42	parallel	parallel	ADJ	JJ	Degree=Pos	_	_	_	_
43	plate	plate	NOUN	NN	Number=Sing	_	_	_	_
44	flow	flow	NOUN	NN	Number=Sing	_	_	_	_
45	chamber	chamber	NOUN	NN	Number=Sing	_	_	_	_
46	under	under	ADP	IN	_	_	_	_	_
47	laminar	laminar	ADJ	JJ	Degree=Pos	_	_	_	_
48	flow	flow	NOUN	NN	Number=Sing	_	_	_	_
49	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
50	1.5	1.5	NUM	CD	NumType=Card	_	_	_	_
51	dynes	dyne	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
52	/	/	SYM	SYM	_	_	_	_	SpaceAfter=No
53	cm2	cm2	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
54	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
55	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 588
# text = Adherent cells were counted by digital image analysis.
1	Adherent	adherent	ADJ	JJ	Degree=Pos	_	_	_	_
2	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
3	were	be	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
4	counted	count	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
5	by	by	ADP	IN	_	_	_	_	_
6	digital	digital	ADJ	JJ	Degree=Pos	_	_	_	_
7	image	image	NOUN	NN	Number=Sing	_	_	_	_
8	analysis	analysis	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
9	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 589
# text = Xenogeneic human serum significantly (P < 0.01) increased the number of adherent leukocytes as compared with porcine serum.
1	Xenogeneic	Xenogeneic	ADJ	JJ	Degree=Pos	_	_	_	_
2	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
3	serum	serum	NOUN	NN	Number=Sing	_	_	_	_
4	significantly	significantly	ADV	RB	_	_	_	_	_
5	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
6	P	p	NOUN	NN	Number=Sing	_	_	_	_
7	<	<	PUNCT	-LRB-	_	_	_	_	_
8	0.01	0.01	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
9	)	)	PUNCT	-RRB-	_	_	_	_	_
10	increased	increase	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
11	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
12	number	number	NOUN	NN	Number=Sing	_	_	_	_
13	of	of	ADP	IN	_	_	_	_	_
14	adherent	adherent	ADJ	JJ	Degree=Pos	_	_	_	_
15	leukocytes	leukocyte	NOUN	NNS	Number=Plur	_	_	_	_
16	as	as	SCONJ	IN	_	_	_	_	_
17	compared	compare	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
18	with	with	ADP	IN	_	_	_	_	_
19	porcine	porcine	NOUN	NN	Number=Sing	_	_	_	_
20	serum	serum	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
21	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 590
# text = A similar adhesive response was elicited by TNF alpha (100 U/ml), one of the most potent inducers of endothelial cell adhesive properties, here used as positive control.
1	A	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
2	similar	similar	ADJ	JJ	Degree=Pos	_	_	_	_
3	adhesive	adhesive	ADJ	JJ	Degree=Pos	_	_	_	_
4	response	response	NOUN	NN	Number=Sing	_	_	_	_
5	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
6	elicited	elicit	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
7	by	by	ADP	IN	_	_	_	_	_
8	TNF	TNF	PROPN	NNP	Number=Sing	_	_	_	_
9	alpha	alpha	PROPN	NNP	Number=Sing	_	_	_	_
10	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
11	100	100	NUM	CD	NumType=Card	_	_	_	_
12	U/	U/	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
13	ml	ml	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
14	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
15	,	,	PUNCT	,	_	_	_	_	_
16	one	one	NUM	CD	NumType=Card	_	_	_	_
17	of	of	ADP	IN	_	_	_	_	_
18	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
19	most	most	ADV	RBS	_	_	_	_	_
20	potent	potent	ADJ	JJ	Degree=Pos	_	_	_	_
21	inducers	inducer	NOUN	NNS	Number=Plur	_	_	_	_
22	of	of	ADP	IN	_	_	_	_	_
23	endothelial	endothelial	ADJ	JJ	Degree=Pos	_	_	_	_
24	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
25	adhesive	adhesive	ADJ	JJ	Degree=Pos	_	_	_	_
26	properties	property	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
27	,	,	PUNCT	,	_	_	_	_	_
28	here	here	ADV	RB	PronType=Dem	_	_	_	_
29	used	use	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
30	as	as	ADP	IN	_	_	_	_	_
31	positive	positive	ADJ	JJ	Degree=Pos	_	_	_	_
32	control	control	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
33	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 591
# text = In order to elucidate possible mechanisms underlying endothelial cell activation by xenogeneic serum, we focussed on transcription factor NF-kappa B, a central regulator for the induction of different genes, including adhesive molecules and chemoattractants.
1	In	in	ADP	IN	_	_	_	_	_
2	order	order	NOUN	NN	Number=Sing	_	_	_	_
3	to	to	PART	TO	_	_	_	_	_
4	elucidate	elucidate	VERB	VB	VerbForm=Inf	_	_	_	_
5	possible	possible	ADJ	JJ	Degree=Pos	_	_	_	_
6	mechanisms	mechanism	NOUN	NNS	Number=Plur	_	_	_	_
7	underlying	underly	VERB	VBG	VerbForm=Ger	_	_	_	_
8	endothelial	endothelial	ADJ	JJ	Degree=Pos	_	_	_	_
9	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
10	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
11	by	by	ADP	IN	_	_	_	_	_
12	xenogeneic	xenogeneic	ADJ	JJ	Degree=Pos	_	_	_	_
13	serum	serum	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
14	,	,	PUNCT	,	_	_	_	_	_
15	we	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
16	focussed	focuss	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
17	on	on	ADP	IN	_	_	_	_	_
18	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
19	factor	factor	NOUN	NN	Number=Sing	_	_	_	_
20	NF	Nf	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
21	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
22	kappa	kappa	PROPN	NNP	Number=Sing	_	_	_	_
23	B	b	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
24	,	,	PUNCT	,	_	_	_	_	_
25	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
26	central	central	ADJ	JJ	Degree=Pos	_	_	_	_
27	regulator	regulator	NOUN	NN	Number=Sing	_	_	_	_
28	for	for	ADP	IN	_	_	_	_	_
29	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
30	induction	induction	NOUN	NN	Number=Sing	_	_	_	_
31	of	of	ADP	IN	_	_	_	_	_
32	different	different	ADJ	JJ	Degree=Pos	_	_	_	_
33	genes	gene	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
34	,	,	PUNCT	,	_	_	_	_	_
35	including	include	VERB	VBG	VerbForm=Ger	_	_	_	_
36	adhesive	adhesive	ADJ	JJ	Degree=Pos	_	_	_	_
37	molecules	molecule	NOUN	NNS	Number=Plur	_	_	_	_
38	and	and	CCONJ	CC	_	_	_	_	_
39	chemoattractants	chemoattractant	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
40	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 592
# text = By confocal fluorescence microscopy, we observed a positive staining for NF-kappa B (p65 subunit) in the nuclei of PAEC exposed for 1 hr 30 min to human serum, which indicated NF-kappa B activation in this setting.
1	By	by	ADP	IN	_	_	_	_	_
2	confocal	confocal	ADJ	JJ	Degree=Pos	_	_	_	_
3	fluorescence	fluorescence	NOUN	NN	Number=Sing	_	_	_	_
4	microscopy	microscopy	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
5	,	,	PUNCT	,	_	_	_	_	_
6	we	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
7	observed	observe	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
8	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
9	positive	positive	ADJ	JJ	Degree=Pos	_	_	_	_
10	staining	staining	NOUN	NN	Number=Sing	_	_	_	_
11	for	for	ADP	IN	_	_	_	_	_
12	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
13	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
14	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_
15	B	b	NOUN	NN	Number=Sing	_	_	_	_
16	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
17	p65	p65	NUM	CD	NumType=Card	_	_	_	_
18	subunit	subunit	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
19	)	)	PUNCT	-RRB-	_	_	_	_	_
20	in	in	ADP	IN	_	_	_	_	_
21	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
22	nuclei	nuclei	NOUN	NN	Number=Sing	_	_	_	_
23	of	of	ADP	IN	_	_	_	_	_
24	PAEC	PAEC	PROPN	NNP	Number=Sing	_	_	_	_
25	exposed	expose	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
26	for	for	ADP	IN	_	_	_	_	_
27	1	1	NUM	CD	NumType=Card	_	_	_	_
28	hr	hr	NOUN	NN	Number=Sing	_	_	_	_
29	30	30	NUM	CD	NumType=Card	_	_	_	_
30	min	min	NOUN	NNS	Number=Plur	_	_	_	_
31	to	to	ADP	IN	_	_	_	_	_
32	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
33	serum	serum	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
34	,	,	PUNCT	,	_	_	_	_	_
35	which	which	PRON	WDT	PronType=Rel	_	_	_	_
36	indicated	indicate	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
37	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
38	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
39	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_
40	B	b	NOUN	NN	Number=Sing	_	_	_	_
41	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
42	in	in	ADP	IN	_	_	_	_	_
43	this	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
44	setting	setting	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
45	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 593
# text = At variance, in PAEC incubated with the homologous serum, NF-kappa B was strictly localized in the cell cytoplasm.
1	At	at	ADP	IN	_	_	_	_	_
2	variance	variance	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
3	,	,	PUNCT	,	_	_	_	_	_
4	in	in	ADP	IN	_	_	_	_	_
5	PAEC	PAEC	PROPN	NNP	Number=Sing	_	_	_	_
6	incubated	incubate	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
7	with	with	ADP	IN	_	_	_	_	_
8	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
9	homologous	homologous	ADJ	JJ	Degree=Pos	_	_	_	_
10	serum	serum	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
11	,	,	PUNCT	,	_	_	_	_	_
12	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
13	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
14	kappa	kappa	PROPN	NNP	Number=Sing	_	_	_	_
15	B	b	PROPN	NNP	Number=Sing	_	_	_	_
16	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
17	strictly	strictly	ADV	RB	_	_	_	_	_
18	localized	localize	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
19	in	in	ADP	IN	_	_	_	_	_
20	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
21	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
22	cytoplasm	cytoplasm	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
23	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 594
# text = Treatment of PAEC exposed to xenogeneic serum with the NF-kappa B inhibitors pyrrolidinedithiocarbamate (PDTC, 25 microM) and tosyl-phechloromethylketone (TPCK, 25 microM) significantly (P < 0.01) reduced leukocyte adhesion in respect to PAEC treated with human serum alone.
1	Treatment	treatment	NOUN	NN	Number=Sing	_	_	_	_
2	of	of	ADP	IN	_	_	_	_	_
3	PAEC	PAEC	PROPN	NNP	Number=Sing	_	_	_	_
4	exposed	expose	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
5	to	to	ADP	IN	_	_	_	_	_
6	xenogeneic	xenogeneic	ADJ	JJ	Degree=Pos	_	_	_	_
7	serum	serum	NOUN	NN	Number=Sing	_	_	_	_
8	with	with	ADP	IN	_	_	_	_	_
9	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
10	NF	Nf	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
11	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
12	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_
13	B	b	NOUN	NN	Number=Sing	_	_	_	_
14	inhibitors	inhibitor	NOUN	NNS	Number=Plur	_	_	_	_
15	pyrrolidinedithiocarbamate	pyrrolidinedithiocarbamate	NOUN	NN	Number=Sing	_	_	_	_
16	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
17	PDTC	PDTC	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
18	,	,	PUNCT	,	_	_	_	_	_
19	25	25	NUM	CD	NumType=Card	_	_	_	_
20	microM	microm	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
21	)	)	PUNCT	-RRB-	_	_	_	_	_
22	and	and	CCONJ	CC	_	_	_	_	_
23	tosyl	tosyl	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
24	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
25	phechloromethylketone	phechloromethylketone	NOUN	NN	Number=Sing	_	_	_	_
26	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
27	TPCK	TPCK	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
28	,	,	PUNCT	,	_	_	_	_	_
29	25	25	NUM	CD	NumType=Card	_	_	_	_
30	microM	microm	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
31	)	)	PUNCT	-RRB-	_	_	_	_	_
32	significantly	significantly	ADV	RB	_	_	_	_	_
33	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
34	P	p	NOUN	NN	Number=Sing	_	_	_	_
35	<	<	PUNCT	-LRB-	_	_	_	_	_
36	0.01	0.01	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
37	)	)	PUNCT	-RRB-	_	_	_	_	_
38	reduced	reduce	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
39	leukocyte	leukocyte	NOUN	NN	Number=Sing	_	_	_	_
40	adhesion	adhesion	NOUN	NN	Number=Sing	_	_	_	_
41	in	in	ADP	IN	_	_	_	_	_
42	respect	respect	NOUN	NN	Number=Sing	_	_	_	_
43	to	to	ADP	IN	_	_	_	_	_
44	PAEC	PAEC	PROPN	NNP	Number=Sing	_	_	_	_
45	treated	treat	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
46	with	with	ADP	IN	_	_	_	_	_
47	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
48	serum	serum	NOUN	NN	Number=Sing	_	_	_	_
49	alone	alone	ADV	RB	_	_	_	_	SpaceAfter=No
50	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 595
# text = Findings that xenogeneic serum promotes leukocyte-endothelium interaction possibly through NF-kappa B activation might be relevant for designing future therapeutic strategies aimed at prolonging xenograft survival.
1	Findings	finding	NOUN	NNS	Number=Plur	_	_	_	_
2	that	that	SCONJ	IN	_	_	_	_	_
3	xenogeneic	xenogeneic	ADJ	JJ	Degree=Pos	_	_	_	_
4	serum	serum	NOUN	NN	Number=Sing	_	_	_	_
5	promotes	promote	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
6	leukocyte	leukocyte	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
7	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
8	endothelium	endothelium	NOUN	NN	Number=Sing	_	_	_	_
9	interaction	interaction	NOUN	NN	Number=Sing	_	_	_	_
10	possibly	possibly	ADV	RB	_	_	_	_	_
11	through	through	ADP	IN	_	_	_	_	_
12	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
13	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
14	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_
15	B	b	NOUN	NN	Number=Sing	_	_	_	_
16	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
17	might	might	AUX	MD	VerbForm=Fin	_	_	_	_
18	be	be	AUX	VB	VerbForm=Inf	_	_	_	_
19	relevant	relevant	ADJ	JJ	Degree=Pos	_	_	_	_
20	for	for	SCONJ	IN	_	_	_	_	_
21	designing	design	VERB	VBG	VerbForm=Ger	_	_	_	_
22	future	future	ADJ	JJ	Degree=Pos	_	_	_	_
23	therapeutic	therapeutic	ADJ	JJ	Degree=Pos	_	_	_	_
24	strategies	strategy	NOUN	NNS	Number=Plur	_	_	_	_
25	aimed	aim	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
26	at	at	SCONJ	IN	_	_	_	_	_
27	prolonging	prolonge	VERB	VBG	VerbForm=Ger	_	_	_	_
28	xenograft	xenograft	NOUN	NN	Number=Sing	_	_	_	_
29	survival	survival	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
30	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 596
# text = Document 003002202 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	003002202	003002202	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 597
# text = Epstein-Barr virus replicative gene transcription during de novo infection of human thymocytes: simultaneous early expression of BZLF-1 and its repressor RAZ.
1	Epstein	Epstein	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
2	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
3	Barr	Barr	PROPN	NNP	Number=Sing	_	_	_	_
4	virus	virus	NOUN	NN	Number=Sing	_	_	_	_
5	replicative	replicative	ADJ	JJ	Degree=Pos	_	_	_	_
6	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
7	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
8	during	during	ADP	IN	_	_	_	_	_
9	de	de	PROPN	NNP	Number=Sing	_	_	_	_
10	novo	novo	PROPN	NNP	Number=Sing	_	_	_	_
11	infection	infection	NOUN	NN	Number=Sing	_	_	_	_
12	of	of	ADP	IN	_	_	_	_	_
13	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
14	thymocytes	thymocyte	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
15	:	:	PUNCT	:	_	_	_	_	_
16	simultaneous	simultaneous	ADJ	JJ	Degree=Pos	_	_	_	_
17	early	early	ADJ	JJ	Degree=Pos	_	_	_	_
18	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
19	of	of	ADP	IN	_	_	_	_	_
20	BZLF	BZLF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
21	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
22	1	1	NUM	CD	NumType=Card	_	_	_	_
23	and	and	CCONJ	CC	_	_	_	_	_
24	its	its	PRON	PRP$	Gender=Neut|Number=Sing|Person=3|Poss=Yes|PronType=Prs	_	_	_	_
25	repressor	repressor	NOUN	NN	Number=Sing	_	_	_	_
26	RAZ	Raz	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
27	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 598
# text = Epstein-Barr virus (EBV) is known to infect B cells and epithelial cells.
1	Epstein	Epstein	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
2	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
3	Barr	Barr	PROPN	NNP	Number=Sing	_	_	_	_
4	virus	virus	NOUN	NN	Number=Sing	_	_	_	_
5	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
6	EBV	EBV	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
7	)	)	PUNCT	-RRB-	_	_	_	_	_
8	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
9	known	know	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
10	to	to	PART	TO	_	_	_	_	_
11	infect	infect	VERB	VB	VerbForm=Inf	_	_	_	_
12	B	b	ADJ	JJ	Degree=Pos	_	_	_	_
13	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
14	and	and	CCONJ	CC	_	_	_	_	_
15	epithelial	epithelial	ADJ	JJ	Degree=Pos	_	_	_	_
16	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
17	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 599
# text = We and others have shown that EBV can also infect a subset of thymocytes.
1	We	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
2	and	and	CCONJ	CC	_	_	_	_	_
3	others	other	NOUN	NNS	Number=Plur	_	_	_	_
4	have	have	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
5	shown	show	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
6	that	that	SCONJ	IN	_	_	_	_	_
7	EBV	EBV	PROPN	NNP	Number=Sing	_	_	_	_
8	can	can	AUX	MD	VerbForm=Fin	_	_	_	_
9	also	also	ADV	RB	_	_	_	_	_
10	infect	infect	VERB	VB	VerbForm=Inf	_	_	_	_
11	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
12	subset	subset	NOUN	NN	Number=Sing	_	_	_	_
13	of	of	ADP	IN	_	_	_	_	_
14	thymocytes	thymocyte	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
15	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 600
# text = Infection of thymocytes was accompanied by the appearance of linear EBV genome within 8 hr of infection.
1	Infection	Infection	NOUN	NN	Number=Sing	_	_	_	_
2	of	of	ADP	IN	_	_	_	_	_
3	thymocytes	thymocyte	NOUN	NNS	Number=Plur	_	_	_	_
4	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
5	accompanied	accompany	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
6	by	by	ADP	IN	_	_	_	_	_
7	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
8	appearance	appearance	NOUN	NN	Number=Sing	_	_	_	_
9	of	of	ADP	IN	_	_	_	_	_
10	linear	linear	NOUN	NN	Number=Sing	_	_	_	_
11	EBV	EBV	NOUN	NN	Number=Sing	_	_	_	_
12	genome	genome	NOUN	NN	Number=Sing	_	_	_	_
13	within	within	ADP	IN	_	_	_	_	_
14	8	8	NUM	CD	NumType=Card	_	_	_	_
15	hr	hr	NOUN	NN	Number=Sing	_	_	_	_
16	of	of	ADP	IN	_	_	_	_	_
17	infection	infection	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
18	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 601
# text = Circularization of the EBV genome was not detected.
1	Circularization	Circularization	NOUN	NN	Number=Sing	_	_	_	_
2	of	of	ADP	IN	_	_	_	_	_
3	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
4	EBV	EBV	PROPN	NNP	Number=Sing	_	_	_	_
5	genome	genome	NOUN	NN	Number=Sing	_	_	_	_
6	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
7	not	not	PART	RB	_	_	_	_	_
8	detected	detect	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	SpaceAfter=No
9	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 602
# text = This is in contrast to the infection in B cells where the genome can circularize within 24 hr of infection.
1	This	this	PRON	DT	Number=Sing|PronType=Dem	_	_	_	_
2	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
3	in	in	ADP	IN	_	_	_	_	_
4	contrast	contrast	NOUN	NN	Number=Sing	_	_	_	_
5	to	to	ADP	IN	_	_	_	_	_
6	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
7	infection	infection	NOUN	NN	Number=Sing	_	_	_	_
8	in	in	ADP	IN	_	_	_	_	_
9	B	b	ADJ	JJ	Degree=Pos	_	_	_	_
10	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
11	where	where	ADV	WRB	PronType=Rel	_	_	_	_
12	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
13	genome	genome	NOUN	NN	Number=Sing	_	_	_	_
14	can	can	AUX	MD	VerbForm=Fin	_	_	_	_
15	circularize	circularize	VERB	VB	VerbForm=Inf	_	_	_	_
16	within	within	ADP	IN	_	_	_	_	_
17	24	24	NUM	CD	NumType=Card	_	_	_	_
18	hr	hr	NOUN	NN	Number=Sing	_	_	_	_
19	of	of	ADP	IN	_	_	_	_	_
20	infection	infection	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
21	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 603
# text = The appearance of the BamHI ZLF-1 gene product, ZEBRA, by RT-PCR, was observed within 8 hr of infection.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	appearance	appearance	NOUN	NN	Number=Sing	_	_	_	_
3	of	of	ADP	IN	_	_	_	_	_
4	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
5	BamHI	BamHI	PROPN	NNP	Number=Sing	_	_	_	_
6	ZLF	ZLF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
7	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
8	1	1	NUM	CD	NumType=Card	_	_	_	_
9	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
10	product	product	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
11	,	,	PUNCT	,	_	_	_	_	_
12	ZEBRA	zebra	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
13	,	,	PUNCT	,	_	_	_	_	_
14	by	by	ADP	IN	_	_	_	_	_
15	RT	Rt	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
16	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
17	PCR	PCR	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
18	,	,	PUNCT	,	_	_	_	_	_
19	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
20	observed	observe	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
21	within	within	ADP	IN	_	_	_	_	_
22	8	8	NUM	CD	NumType=Card	_	_	_	_
23	hr	hr	NOUN	NN	Number=Sing	_	_	_	_
24	of	of	ADP	IN	_	_	_	_	_
25	infection	infection	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
26	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 604
# text = The appearance of a novel fusion transcript (RAZ), which comprised regions of the BZLF-1 locus and the adjacent BRLF-1 locus, was detected by RT-PCR.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	appearance	appearance	NOUN	NN	Number=Sing	_	_	_	_
3	of	of	ADP	IN	_	_	_	_	_
4	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
5	novel	novel	NOUN	NN	Number=Sing	_	_	_	_
6	fusion	fusion	NOUN	NN	Number=Sing	_	_	_	_
7	transcript	transcript	NOUN	NN	Number=Sing	_	_	_	_
8	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
9	RAZ	RAZ	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
10	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
11	,	,	PUNCT	,	_	_	_	_	_
12	which	which	PRON	WDT	PronType=Rel	_	_	_	_
13	comprised	comprise	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
14	regions	region	NOUN	NNS	Number=Plur	_	_	_	_
15	of	of	ADP	IN	_	_	_	_	_
16	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
17	BZLF	BZLF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
18	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
19	1	1	NUM	CD	NumType=Card	_	_	_	_
20	locus	locus	NOUN	NN	Number=Sing	_	_	_	_
21	and	and	CCONJ	CC	_	_	_	_	_
22	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
23	adjacent	adjacent	ADJ	JJ	Degree=Pos	_	_	_	_
24	BRLF	BRLF	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
25	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
26	1	1	NUM	CD	NumType=Card	_	_	_	_
27	locus	locus	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
28	,	,	PUNCT	,	_	_	_	_	_
29	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
30	detected	detect	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
31	by	by	ADP	IN	_	_	_	_	_
32	RT	Rt	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
33	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
34	PCR	PCR	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
35	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 605
# text = ZEBRA protein was also identified in infected thymocytes by immunoprecipitation.
1	ZEBRA	zebra	NOUN	NN	Number=Sing	_	_	_	_
2	protein	protein	NOUN	NN	Number=Sing	_	_	_	_
3	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
4	also	also	ADV	RB	_	_	_	_	_
5	identified	identify	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
6	in	in	ADP	IN	_	_	_	_	_
7	infected	infect	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
8	thymocytes	thymocyte	NOUN	NNS	Number=Plur	_	_	_	_
9	by	by	ADP	IN	_	_	_	_	_
10	immunoprecipitation	immunoprecipitation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
11	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 606
# text = In addition, we demonstrated that the EBNA-1 gene in infected thymocytes was transcribed from the Fp promoter, rather than from the Cp/Wp promoter which is used in latently infected B cells.
1	In	in	ADP	IN	_	_	_	_	_
2	addition	addition	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
3	,	,	PUNCT	,	_	_	_	_	_
4	we	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
5	demonstrated	demonstrate	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
6	that	that	SCONJ	IN	_	_	_	_	_
7	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
8	EBNA	EBNA	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
9	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
10	1	1	NUM	CD	NumType=Card	_	_	_	_
11	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
12	in	in	ADP	IN	_	_	_	_	_
13	infected	infected	ADJ	JJ	Degree=Pos	_	_	_	_
14	thymocytes	thymocyte	NOUN	NNS	Number=Plur	_	_	_	_
15	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
16	transcribed	transcribe	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
17	from	from	ADP	IN	_	_	_	_	_
18	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
19	Fp	Fp	PROPN	NNP	Number=Sing	_	_	_	_
20	promoter	promoter	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
21	,	,	PUNCT	,	_	_	_	_	_
22	rather	rather	ADV	RB	_	_	_	_	_
23	than	than	ADP	IN	_	_	_	_	_
24	from	from	ADP	IN	_	_	_	_	_
25	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
26	Cp/	cp/	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
27	Wp	Wp	NOUN	NN	Number=Sing	_	_	_	_
28	promoter	promoter	NOUN	NN	Number=Sing	_	_	_	_
29	which	which	PRON	WDT	PronType=Rel	_	_	_	_
30	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
31	used	use	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
32	in	in	ADP	IN	_	_	_	_	_
33	latently	latently	ADV	RB	_	_	_	_	_
34	infected	infect	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
35	B	b	ADJ	JJ	Degree=Pos	_	_	_	_
36	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
37	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 607
# text = Transcripts encoding gp350/220, the major coat protein of EBV, were identified, but we did not find any evidence of transcription from the LMP-2A or EBER-1 loci in infected thymocytes.
1	Transcripts	transcript	NOUN	NNS	Number=Plur	_	_	_	_
2	encoding	encod	VERB	VBG	VerbForm=Ger	_	_	_	_
3	gp350	gp350	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
4	/	/	SYM	SYM	_	_	_	_	SpaceAfter=No
5	220	220	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
6	,	,	PUNCT	,	_	_	_	_	_
7	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
8	major	major	ADJ	JJ	Degree=Pos	_	_	_	_
9	coat	coat	NOUN	NN	Number=Sing	_	_	_	_
10	protein	protein	NOUN	NN	Number=Sing	_	_	_	_
11	of	of	ADP	IN	_	_	_	_	_
12	EBV	EBV	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
13	,	,	PUNCT	,	_	_	_	_	_
14	were	be	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
15	identified	identify	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	SpaceAfter=No
16	,	,	PUNCT	,	_	_	_	_	_
17	but	but	CCONJ	CC	_	_	_	_	_
18	we	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
19	did	do	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
20	not	not	PART	RB	_	_	_	_	_
21	find	find	VERB	VB	VerbForm=Inf	_	_	_	_
22	any	any	DET	DT	_	_	_	_	_
23	evidence	evidence	NOUN	NN	Number=Sing	_	_	_	_
24	of	of	ADP	IN	_	_	_	_	_
25	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
26	from	from	ADP	IN	_	_	_	_	_
27	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
28	LMP	LMP	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
29	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
30	2A	2A	PROPN	NNP	Number=Sing	_	_	_	_
31	or	or	CCONJ	CC	_	_	_	_	_
32	EBER	EBER	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
33	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
34	1	1	NUM	CD	NumType=Card	_	_	_	_
35	loci	loci	NOUN	NN	Number=Sing	_	_	_	_
36	in	in	ADP	IN	_	_	_	_	_
37	infected	infect	ADJ	JJ	Degree=Pos	_	_	_	_
38	thymocytes	thymocyte	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
39	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 608
# text = These observations suggest that de novo EBV infection of thymocytes differs from infection of B cells.
1	These	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
2	observations	observation	NOUN	NNS	Number=Plur	_	_	_	_
3	suggest	suggest	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
4	that	that	SCONJ	IN	_	_	_	_	_
5	de	de	PROPN	NNP	Number=Sing	_	_	_	_
6	novo	novo	PROPN	NNP	Number=Sing	_	_	_	_
7	EBV	EBV	PROPN	NNP	Number=Sing	_	_	_	_
8	infection	infection	NOUN	NN	Number=Sing	_	_	_	_
9	of	of	ADP	IN	_	_	_	_	_
10	thymocytes	thymocyte	NOUN	NNS	Number=Plur	_	_	_	_
11	differs	differ	NOUN	NNS	Number=Plur	_	_	_	_
12	from	from	ADP	IN	_	_	_	_	_
13	infection	infection	NOUN	NN	Number=Sing	_	_	_	_
14	of	of	ADP	IN	_	_	_	_	_
15	B	b	ADJ	JJ	Degree=Pos	_	_	_	_
16	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
17	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 609
# text = The main difference is that with thymocytes, no evidence could be found that the virus ever circularizes.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	main	main	ADJ	JJ	Degree=Pos	_	_	_	_
3	difference	difference	NOUN	NN	Number=Sing	_	_	_	_
4	is	be	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
5	that	that	SCONJ	IN	_	_	_	_	_
6	with	with	ADP	IN	_	_	_	_	_
7	thymocytes	thymocyte	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
8	,	,	PUNCT	,	_	_	_	_	_
9	no	no	DET	DT	_	_	_	_	_
10	evidence	evidence	NOUN	NN	Number=Sing	_	_	_	_
11	could	could	AUX	MD	VerbForm=Fin	_	_	_	_
12	be	be	AUX	VB	VerbForm=Inf	_	_	_	_
13	found	find	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
14	that	that	SCONJ	IN	_	_	_	_	_
15	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
16	virus	virus	NOUN	NN	Number=Sing	_	_	_	_
17	ever	ever	ADV	RB	_	_	_	_	_
18	circularizes	circularize	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	SpaceAfter=No
19	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 610
# text = Rather, EBV remains in a linear configuration from which replicative genes are transcribed.
1	Rather	Rather	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
2	,	,	PUNCT	,	_	_	_	_	_
3	EBV	EBV	PROPN	NNP	Number=Sing	_	_	_	_
4	remains	remain	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
5	in	in	ADP	IN	_	_	_	_	_
6	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
7	linear	linear	NOUN	NN	Number=Sing	_	_	_	_
8	configuration	configuration	NOUN	NN	Number=Sing	_	_	_	_
9	from	from	ADP	IN	_	_	_	_	_
10	which	which	PRON	WDT	PronType=Rel	_	_	_	_
11	replicative	replicative	ADJ	JJ	Degree=Pos	_	_	_	_
12	genes	gene	NOUN	NNS	Number=Plur	_	_	_	_
13	are	be	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
14	transcribed	transcribe	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	SpaceAfter=No
15	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 611
# text = Document 003002203 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	003002203	003002203	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 612
# text = Second messenger up-regulation of androgen receptor gene transcription is absent in androgen insensitive human prostatic carcinoma cell lines, PC-3 and DU-145.
1	Second	second	ADJ	JJ	Degree=Pos|NumType=Ord	_	_	_	_
2	messenger	messenger	NOUN	NN	Number=Sing	_	_	_	_
3	up	up	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
4	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
5	regulation	regulation	NOUN	NN	Number=Sing	_	_	_	_
6	of	of	ADP	IN	_	_	_	_	_
7	androgen	androgen	ADJ	JJ	Degree=Pos	_	_	_	_
8	receptor	receptor	NOUN	NN	Number=Sing	_	_	_	_
9	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
10	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
11	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
12	absent	absend	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
13	in	in	ADP	IN	_	_	_	_	_
14	androgen	androgen	NUM	CD	NumType=Card	_	_	_	_
15	insensitive	insensitive	ADJ	JJ	Degree=Pos	_	_	_	_
16	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
17	prostatic	prostatic	ADJ	JJ	Degree=Pos	_	_	_	_
18	carcinoma	carcinoma	NOUN	NN	Number=Sing	_	_	_	_
19	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
20	lines	line	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
21	,	,	PUNCT	,	_	_	_	_	_
22	PC	PC	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
23	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
24	3	3	NUM	CD	NumType=Card	_	_	_	_
25	and	and	CCONJ	CC	_	_	_	_	_
26	DU	du	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
27	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
28	145	145	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
29	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 613
# text = A theoretical pathway of transcriptional regulation of the androgen receptor (AR) gene is via a cAMP response element (CRE) present in its promoter region (-508 to -501).
1	A	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
2	theoretical	theoretical	ADJ	JJ	Degree=Pos	_	_	_	_
3	pathway	pathway	NOUN	NN	Number=Sing	_	_	_	_
4	of	of	ADP	IN	_	_	_	_	_
5	transcriptional	transcriptional	ADJ	JJ	Degree=Pos	_	_	_	_
6	regulation	regulation	NOUN	NN	Number=Sing	_	_	_	_
7	of	of	ADP	IN	_	_	_	_	_
8	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
9	androgen	androgen	ADJ	JJ	Degree=Pos	_	_	_	_
10	receptor	receptor	NOUN	NN	Number=Sing	_	_	_	_
11	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
12	AR	be	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
13	)	)	PUNCT	-RRB-	_	_	_	_	_
14	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
15	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
16	via	via	ADP	IN	_	_	_	_	_
17	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
18	cAMP	camp	NOUN	NN	Number=Sing	_	_	_	_
19	response	response	NOUN	NN	Number=Sing	_	_	_	_
20	element	element	NOUN	NN	Number=Sing	_	_	_	_
21	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
22	CRE	CRE	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
23	)	)	PUNCT	-RRB-	_	_	_	_	_
24	present	present	ADJ	JJ	Degree=Pos	_	_	_	_
25	in	in	ADP	IN	_	_	_	_	_
26	its	its	PRON	PRP$	Gender=Neut|Number=Sing|Person=3|Poss=Yes|PronType=Prs	_	_	_	_
27	promoter	promoter	NOUN	NN	Number=Sing	_	_	_	_
28	region	region	NOUN	NN	Number=Sing	_	_	_	_
29	(-	(-	PUNCT	.	_	_	_	_	SpaceAfter=No
30	508	508	NUM	CD	NumType=Card	_	_	_	_
31	to	to	ADP	IN	_	_	_	_	_
32	-	-	SYM	SYM	_	_	_	_	SpaceAfter=No
33	501	501	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
34	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
35	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 614
# text = After 20 h of stimulation with 8-bromo-cAMP, AR mRNA was upregulated in LNCaP but not in either PC-3 or DU-145 cell lines.
1	After	after	ADP	IN	_	_	_	_	_
2	20	20	NUM	CD	NumType=Card	_	_	_	_
3	h	h	NOUN	NN	Number=Sing	_	_	_	_
4	of	of	ADP	IN	_	_	_	_	_
5	stimulation	stimulation	NOUN	NN	Number=Sing	_	_	_	_
6	with	with	ADP	IN	_	_	_	_	_
7	8	8	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
8	-	-	PUNCT	:	_	_	_	_	SpaceAfter=No
9	bromo-cAMP	bromo-camp	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
10	,	,	PUNCT	,	_	_	_	_	_
11	AR	ar	PROPN	NNP	Number=Sing	_	_	_	_
12	mRNA	mRNA	PROPN	NNP	Number=Sing	_	_	_	_
13	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
14	upregulated	upregulate	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
15	in	in	ADP	IN	_	_	_	_	_
16	LNCaP	LNCaP	NOUN	NN	Number=Sing	_	_	_	_
17	but	but	CCONJ	CC	_	_	_	_	_
18	not	not	PART	RB	_	_	_	_	_
19	in	in	ADP	IN	_	_	_	_	_
20	either	either	DET	DT	_	_	_	_	_
21	PC	PC	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
22	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
23	3	3	NUM	CD	NumType=Card	_	_	_	_
24	or	or	CCONJ	CC	_	_	_	_	_
25	DU	do	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
26	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
27	145	145	NUM	CD	NumType=Card	_	_	_	_
28	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
29	lines	line	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
30	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 615
# text = We have demonstrated that the level of CRE binding protein (CREB) was the same in all cell lines and that the putative AR-CRE forms specific and compatible protein interactions with CREB.
1	We	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
2	have	have	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
3	demonstrated	demonstrate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
4	that	that	SCONJ	IN	_	_	_	_	_
5	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
6	level	level	NOUN	NN	Number=Sing	_	_	_	_
7	of	of	ADP	IN	_	_	_	_	_
8	CRE	Cre	PROPN	NNP	Number=Sing	_	_	_	_
9	binding	binding	VERB	VBG	VerbForm=Ger	_	_	_	_
10	protein	protein	NOUN	NN	Number=Sing	_	_	_	_
11	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
12	CREB	CREB	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
13	)	)	PUNCT	-RRB-	_	_	_	_	_
14	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
15	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
16	same	same	ADJ	JJ	Degree=Pos	_	_	_	_
17	in	in	ADP	IN	_	_	_	_	_
18	all	all	DET	DT	_	_	_	_	_
19	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
20	lines	line	NOUN	NNS	Number=Plur	_	_	_	_
21	and	and	CCONJ	CC	_	_	_	_	_
22	that	that	SCONJ	IN	_	_	_	_	_
23	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
24	putative	putative	ADJ	JJ	Degree=Pos	_	_	_	_
25	AR	ar	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
26	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
27	CRE	Cre	NOUN	NN	Number=Sing	_	_	_	_
28	forms	form	NOUN	NNS	Number=Plur	_	_	_	_
29	specific	specific	ADJ	JJ	Degree=Pos	_	_	_	_
30	and	and	CCONJ	CC	_	_	_	_	_
31	compatible	compatible	ADJ	JJ	Degree=Pos	_	_	_	_
32	protein	protein	NOUN	NN	Number=Sing	_	_	_	_
33	interactions	interaction	NOUN	NNS	Number=Plur	_	_	_	_
34	with	with	ADP	IN	_	_	_	_	_
35	CREB	CREB	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
36	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 616
# text = The ability to regulate AR gene transcription via the second messenger pathway is lost in the PC-3 and DU-145 cell lines.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	ability	ability	NOUN	NN	Number=Sing	_	_	_	_
3	to	to	PART	TO	_	_	_	_	_
4	regulate	regulate	VERB	VB	VerbForm=Inf	_	_	_	_
5	AR	be	ADP	IN	_	_	_	_	_
6	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
7	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
8	via	via	ADP	IN	_	_	_	_	_
9	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
10	second	second	ADJ	JJ	Degree=Pos|NumType=Ord	_	_	_	_
11	messenger	messenger	NOUN	NN	Number=Sing	_	_	_	_
12	pathway	pathway	NOUN	NN	Number=Sing	_	_	_	_
13	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
14	lost	lose	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
15	in	in	ADP	IN	_	_	_	_	_
16	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
17	PC	PC	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
18	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
19	3	3	NUM	CD	NumType=Card	_	_	_	_
20	and	and	CCONJ	CC	_	_	_	_	_
21	DU	do	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
22	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
23	145	145	NUM	CD	NumType=Card	_	_	_	_
24	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
25	lines	line	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
26	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 617
# text = This may be an important primary mechanism of androgen insensitivity in prostate cancer.
1	This	this	PRON	DT	Number=Sing|PronType=Dem	_	_	_	_
2	may	may	AUX	MD	VerbForm=Fin	_	_	_	_
3	be	be	AUX	VB	VerbForm=Inf	_	_	_	_
4	an	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
5	important	important	ADJ	JJ	Degree=Pos	_	_	_	_
6	primary	primary	ADJ	JJ	Degree=Pos	_	_	_	_
7	mechanism	mechanism	NOUN	NN	Number=Sing	_	_	_	_
8	of	of	ADP	IN	_	_	_	_	_
9	androgen	androgen	ADJ	JJ	Degree=Pos	_	_	_	_
10	insensitivity	insensitivity	NOUN	NN	Number=Sing	_	_	_	_
11	in	in	ADP	IN	_	_	_	_	_
12	prostate	prostate	ADJ	JJ	Degree=Pos	_	_	_	_
13	cancer	cancer	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
14	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 618
# text = Document 003002213 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	003002213	003002213	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 619
# text = Evidence for distinct intracellular signaling pathways in CD34+ progenitor to dendritic cell differentiation from a human cell line model.
1	Evidence	evidence	NOUN	NN	Number=Sing	_	_	_	_
2	for	for	ADP	IN	_	_	_	_	_
3	distinct	distinct	ADJ	JJ	Degree=Pos	_	_	_	_
4	intracellular	intracellular	ADJ	JJ	Degree=Pos	_	_	_	_
5	signaling	signaling	NOUN	NN	Number=Sing	_	_	_	_
6	pathways	pathway	NOUN	NNS	Number=Plur	_	_	_	_
7	in	in	ADP	IN	_	_	_	_	_
8	CD34	CD34	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
9	+	+	SYM	SYM	_	_	_	_	_
10	progenitor	progenitor	NOUN	NN	Number=Sing	_	_	_	_
11	to	to	ADP	IN	_	_	_	_	_
12	dendritic	dendritic	ADJ	JJ	Degree=Pos	_	_	_	_
13	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
14	differentiation	differentiation	NOUN	NN	Number=Sing	_	_	_	_
15	from	from	ADP	IN	_	_	_	_	_
16	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
17	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
18	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
19	line	line	NOUN	NN	Number=Sing	_	_	_	_
20	model	model	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
21	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 620
# text = Intracellular signals that mediate differentiation of pluripotent hemopoietic progenitors to dendritic cells (DC) are largely undefined.
1	Intracellular	Intracellular	ADJ	JJ	Degree=Pos	_	_	_	_
2	signals	signal	NOUN	NNS	Number=Plur	_	_	_	_
3	that	that	PRON	WDT	PronType=Rel	_	_	_	_
4	mediate	mediate	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
5	differentiation	differentiation	NOUN	NN	Number=Sing	_	_	_	_
6	of	of	ADP	IN	_	_	_	_	_
7	pluripotent	pluripotent	ADJ	JJ	Degree=Pos	_	_	_	_
8	hemopoietic	hemopoietic	ADJ	JJ	Degree=Pos	_	_	_	_
9	progenitors	progenitor	NOUN	NNS	Number=Plur	_	_	_	_
10	to	to	ADP	IN	_	_	_	_	_
11	dendritic	dendritic	ADJ	JJ	Degree=Pos	_	_	_	_
12	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
13	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
14	DC	DC	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
15	)	)	PUNCT	-RRB-	_	_	_	_	_
16	are	be	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
17	largely	largely	ADV	RB	_	_	_	_	_
18	undefined	undefin	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
19	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 621
# text = We have previously shown that protein kinase C (PKC) activation (with phorbol ester (PMA) alone) specifically induces differentiation of primary human CD34+ hemopoietic progenitor cells (HPC) to mature DC.
1	We	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
2	have	have	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
3	previously	previously	ADV	RB	_	_	_	_	_
4	shown	show	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
5	that	that	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
6	protein	protein	NOUN	NN	Number=Sing	_	_	_	_
7	kinase	kinase	NOUN	NN	Number=Sing	_	_	_	_
8	C	C	PROPN	NNP	Number=Sing	_	_	_	_
9	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
10	PKC	PKC	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
11	)	)	PUNCT	-RRB-	_	_	_	_	_
12	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
13	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
14	with	with	ADP	IN	_	_	_	_	_
15	phorbol	phorbol	NOUN	NN	Number=Sing	_	_	_	_
16	ester	ester	NOUN	NN	Number=Sing	_	_	_	_
17	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
18	PMA	PMA	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
19	)	)	PUNCT	-RRB-	_	_	_	_	_
20	alone	alone	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
21	)	)	PUNCT	-RRB-	_	_	_	_	_
22	specifically	specifically	ADV	RB	_	_	_	_	_
23	induces	induce	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
24	differentiation	differentiation	NOUN	NN	Number=Sing	_	_	_	_
25	of	of	ADP	IN	_	_	_	_	_
26	primary	primary	ADJ	JJ	Degree=Pos	_	_	_	_
27	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
28	CD34	Cd34	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
29	+	+	SYM	SYM	_	_	_	_	_
30	hemopoietic	hemopoietic	ADJ	JJ	Degree=Pos	_	_	_	_
31	progenitor	progenitor	NOUN	NN	Number=Sing	_	_	_	_
32	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
33	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
34	HPC	HPC	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
35	)	)	PUNCT	-RRB-	_	_	_	_	_
36	to	to	PART	TO	_	_	_	_	_
37	mature	mature	VERB	VB	VerbForm=Inf	_	_	_	_
38	DC	DC	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
39	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 622
# text = We now find that cytokine-driven (granulocyte-macrophage CSF and TNF-alpha) CD34+ HPC-->
1	We	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
2	now	now	ADV	RB	_	_	_	_	_
3	find	find	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
4	that	that	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
5	cytokine	cytokine	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
6	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
7	driven	driven	NOUN	NN	Number=Sing	_	_	_	_
8	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
9	granulocyte	granulocyte	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
10	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
11	macrophage	macrophage	NOUN	NN	Number=Sing	_	_	_	_
12	CSF	Csf	NOUN	NN	Number=Sing	_	_	_	_
13	and	and	CCONJ	CC	_	_	_	_	_
14	TNF	Tnf	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
15	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
16	alpha	alpha	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
17	)	)	PUNCT	-RRB-	_	_	_	_	_
18	CD34	CD34	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
19	+	+	SYM	SYM	_	_	_	_	_
20	HPC	HPC	PROPN	NNPS	Number=Plur	_	_	_	SpaceAfter=No
21	-->	-->	SYM	NFP	_	_	_	_	SpaceAfter=No

# sent_id = 623
# text = DC differentiation is preferentially blocked by inhibitors of PKC activation.
1	DC	DC	PROPN	NNP	Number=Sing	_	_	_	_
2	differentiation	differentiation	NOUN	NN	Number=Sing	_	_	_	_
3	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
4	preferentially	preferentially	ADV	RB	_	_	_	_	_
5	blocked	block	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
6	by	by	ADP	IN	_	_	_	_	_
7	inhibitors	inhibitor	NOUN	NNS	Number=Plur	_	_	_	_
8	of	of	ADP	IN	_	_	_	_	_
9	PKC	Pkc	NOUN	NN	Number=Sing	_	_	_	_
10	activation	activation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
11	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 624
# text = To further identify intracellular signals and downstream events important in CD34+ HPC-->
1	To	to	PART	TO	_	_	_	_	_
2	further	further	ADV	RB	_	_	_	_	_
3	identify	identify	VERB	VB	VerbForm=Inf	_	_	_	_
4	intracellular	intracellular	ADJ	JJ	Degree=Pos	_	_	_	_
5	signals	signal	NOUN	NNS	Number=Plur	_	_	_	_
6	and	and	CCONJ	CC	_	_	_	_	_
7	downstream	downstream	ADJ	JJ	Degree=Pos	_	_	_	_
8	events	event	NOUN	NNS	Number=Plur	_	_	_	_
9	important	important	ADJ	JJ	Degree=Pos	_	_	_	_
10	in	in	ADP	IN	_	_	_	_	_
11	CD34	CD34	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
12	+	+	SYM	SYM	_	_	_	_	_
13	HPC	HPC	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
14	-->	-->	SYM	NFP	_	_	_	_	SpaceAfter=No

# sent_id = 625
# text = DC differentiation we have characterized a human leukemic cell line model of this process.
1	DC	DC	PROPN	NNP	Number=Sing	_	_	_	_
2	differentiation	differentiation	NOUN	NN	Number=Sing	_	_	_	_
3	we	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
4	have	have	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
5	characterized	characterize	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
6	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
7	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
8	leukemic	leukemic	ADJ	JJ	Degree=Pos	_	_	_	_
9	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
10	line	line	NOUN	NN	Number=Sing	_	_	_	_
11	model	model	NOUN	NN	Number=Sing	_	_	_	_
12	of	of	ADP	IN	_	_	_	_	_
13	this	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
14	process	process	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
15	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 626
# text = The CD34+ myelomonocytic cell line KG1 differentiates into dendritic-like cells in response to granulocyte-macrophage CSF plus TNF-alpha, or PMA (with or without the calcium ionophore ionomycin, or TNF-alpha), with different stimuli mediating different aspects of the process.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	CD34	CD34	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
3	+	+	SYM	SYM	_	_	_	_	_
4	myelomonocytic	myelomonocytic	ADJ	JJ	Degree=Pos	_	_	_	_
5	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
6	line	line	NOUN	NN	Number=Sing	_	_	_	_
7	KG1	KG1	PROPN	NNP	Number=Sing	_	_	_	_
8	differentiates	differentiate	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
9	into	into	ADP	IN	_	_	_	_	_
10	dendritic	dendritic	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
11	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
12	like	like	ADJ	JJ	Degree=Pos	_	_	_	_
13	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
14	in	in	ADP	IN	_	_	_	_	_
15	response	response	NOUN	NN	Number=Sing	_	_	_	_
16	to	to	PART	TO	_	_	_	_	_
17	granulocyte	granulocyte	VERB	VB	VerbForm=Inf	_	_	_	SpaceAfter=No
18	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
19	macrophage	macrophage	NOUN	NN	Number=Sing	_	_	_	_
20	CSF	Csf	NOUN	NN	Number=Sing	_	_	_	_
21	plus	plus	CCONJ	CC	_	_	_	_	_
22	TNF	Tnf	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
23	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
24	alpha	alpha	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
25	,	,	PUNCT	,	_	_	_	_	_
26	or	or	CCONJ	CC	_	_	_	_	_
27	PMA	Pma	PROPN	NNP	Number=Sing	_	_	_	_
28	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
29	with	with	ADP	IN	_	_	_	_	_
30	or	or	CCONJ	CC	_	_	_	_	_
31	without	without	ADP	IN	_	_	_	_	_
32	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
33	calcium	calcium	NOUN	NN	Number=Sing	_	_	_	_
34	ionophore	ionophore	NOUN	NN	Number=Sing	_	_	_	_
35	ionomycin	ionomycin	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
36	,	,	PUNCT	,	_	_	_	_	_
37	or	or	CCONJ	CC	_	_	_	_	_
38	TNF	Tnf	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
39	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
40	alpha	alpha	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
41	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
42	,	,	PUNCT	,	_	_	_	_	_
43	with	with	ADP	IN	_	_	_	_	_
44	different	different	ADJ	JJ	Degree=Pos	_	_	_	_
45	stimuli	stimuli	NOUN	NN	Number=Sing	_	_	_	_
46	mediating	mediat	VERB	VBG	VerbForm=Ger	_	_	_	_
47	different	different	ADJ	JJ	Degree=Pos	_	_	_	_
48	aspects	aspect	NOUN	NNS	Number=Plur	_	_	_	_
49	of	of	ADP	IN	_	_	_	_	_
50	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
51	process	process	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
52	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 627
# text = Phenotypic DC characteristics of KG1 dendritic-like cells include morphology (loosely adherent cells with long neurite processes), MHC I+/MHC
1	Phenotypic	Phenotypic	PROPN	NNP	Number=Sing	_	_	_	_
2	DC	DC	PROPN	NNP	Number=Sing	_	_	_	_
3	characteristics	characteristic	NOUN	NNS	Number=Plur	_	_	_	_
4	of	of	ADP	IN	_	_	_	_	_
5	KG1	KG1	NUM	CD	NumType=Card	_	_	_	_
6	dendritic	dendritic	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
7	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
8	like	like	ADJ	JJ	Degree=Pos	_	_	_	_
9	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
10	include	include	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
11	morphology	morphology	NOUN	NN	Number=Sing	_	_	_	_
12	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
13	loosely	loosely	ADV	RB	_	_	_	_	_
14	adherent	adherent	ADJ	JJ	Degree=Pos	_	_	_	_
15	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
16	with	with	ADP	IN	_	_	_	_	_
17	long	long	ADJ	JJ	Degree=Pos	_	_	_	_
18	neurite	neurite	NOUN	NN	Number=Sing	_	_	_	_
19	processes	process	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
20	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
21	,	,	PUNCT	,	_	_	_	_	_
22	MHC	MHC	PROPN	NNP	Number=Sing	_	_	_	_
23	I	I	PRON	PRP	Case=Nom|Number=Sing|Person=1|PronType=Prs	_	_	_	SpaceAfter=No
24	+/MHC	+/MHC	PROPN	NNP	Number=Sing	_	_	_	_

# sent_id = 628
# text = IIbright/CD83+/CD86+/CD14- surface
1	IIbright/CD83+/CD86+/CD14	IIbright/CD83+/CD86+/CD14	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
2	-	-	PUNCT	:	_	_	_	_	_
3	surface	surface	NOUN	NN	Number=Sing	_	_	_	_

# sent_id = 629
# text = Ag expression, and RelB and DC-CK1 gene expression.
1	Ag	ag	ADJ	JJ	Degree=Pos	_	_	_	_
2	expression	expression	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
3	,	,	PUNCT	,	_	_	_	_	_
4	and	and	CCONJ	CC	_	_	_	_	_
5	RelB	RelB	PROPN	NNP	Number=Sing	_	_	_	_
6	and	and	CCONJ	CC	_	_	_	_	_
7	DC	DC	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
8	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
9	CK1	CK1	PROPN	NNP	Number=Sing	_	_	_	_
10	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
11	expression	expression	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
12	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 630
# text = Functional DC characteristics include fluid phase macromolecule uptake (FITC-dextran) and activation of resting T cells.
1	Functional	functional	ADJ	JJ	Degree=Pos	_	_	_	_
2	DC	DC	PROPN	NNP	Number=Sing	_	_	_	_
3	characteristics	characteristic	NOUN	NNS	Number=Plur	_	_	_	_
4	include	include	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
5	fluid	fluid	ADJ	JJ	Degree=Pos	_	_	_	_
6	phase	phase	NOUN	NN	Number=Sing	_	_	_	_
7	macromolecule	macromolecule	NOUN	NN	Number=Sing	_	_	_	_
8	uptake	uptake	NOUN	NN	Number=Sing	_	_	_	_
9	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
10	FITC	Fitc	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
11	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
12	dextran	dextran	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
13	)	)	PUNCT	-RRB-	_	_	_	_	_
14	and	and	CCONJ	CC	_	_	_	_	_
15	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
16	of	of	SCONJ	IN	_	_	_	_	_
17	resting	rest	VERB	VBG	VerbForm=Ger	_	_	_	_
18	T	t	PROPN	NNP	Number=Sing	_	_	_	_
19	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
20	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 631
# text = Comparison of KG1 to the PMA-unresponsive subline KG1a reveals differences in expression of TNF receptors 1 and 2; PKC isoforms alpha, beta I, beta II, and mu; and RelB, suggesting that these components/pathways are important for DC differentiation.
1	Comparison	Comparison	NOUN	NN	Number=Sing	_	_	_	_
2	of	of	ADP	IN	_	_	_	_	_
3	KG1	KG1	NUM	CD	NumType=Card	_	_	_	_
4	to	to	ADP	IN	_	_	_	_	_
5	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
6	PMA	PMA	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
7	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
8	unresponsive	unresponsive	ADJ	JJ	Degree=Pos	_	_	_	_
9	subline	subline	NOUN	NN	Number=Sing	_	_	_	_
10	KG1	KG1	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
11	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
12	reveals	reveal	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
13	differences	difference	NOUN	NNS	Number=Plur	_	_	_	_
14	in	in	ADP	IN	_	_	_	_	_
15	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
16	of	of	ADP	IN	_	_	_	_	_
17	TNF	TNF	PROPN	NNP	Number=Sing	_	_	_	_
18	receptors	receptor	NOUN	NNS	Number=Plur	_	_	_	_
19	1	1	NUM	CD	NumType=Card	_	_	_	_
20	and	and	CCONJ	CC	_	_	_	_	_
21	2	2	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
22	;	;	PUNCT	,	_	_	_	_	_
23	PKC	Pkc	NOUN	NN	Number=Sing	_	_	_	_
24	isoforms	isoform	NOUN	NNS	Number=Plur	_	_	_	_
25	alpha	alpha	ADV	RB	_	_	_	_	SpaceAfter=No
26	,	,	PUNCT	,	_	_	_	_	_
27	beta	beto	INTJ	UH	_	_	_	_	_
28	I	I	PRON	PRP	Case=Nom|Number=Sing|Person=1|PronType=Prs	_	_	_	SpaceAfter=No
29	,	,	PUNCT	,	_	_	_	_	_
30	beta	beta	NOUN	NN	Number=Sing	_	_	_	_
31	II	ii	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
32	,	,	PUNCT	,	_	_	_	_	_
33	and	and	CCONJ	CC	_	_	_	_	_
34	mu	mu	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
35	;	;	PUNCT	,	_	_	_	_	_
36	and	and	CCONJ	CC	_	_	_	_	_
37	RelB	Relb	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
38	,	,	PUNCT	,	_	_	_	_	_
39	suggesting	suggest	VERB	VBG	VerbForm=Ger	_	_	_	_
40	that	that	SCONJ	IN	_	_	_	_	_
41	these	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
42	components	component	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
43	/	/	PUNCT	,	_	_	_	_	SpaceAfter=No
44	pathways	pathway	NOUN	NNS	Number=Plur	_	_	_	_
45	are	be	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
46	important	important	ADJ	JJ	Degree=Pos	_	_	_	_
47	for	for	ADP	IN	_	_	_	_	_
48	DC	DC	PROPN	NNP	Number=Sing	_	_	_	_
49	differentiation	differentiation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
50	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 632
# text = Together, these findings demonstrate that cytokine or phorbol ester stimulation of KG1 is a model of human CD34+ HPC to DC differentiation and suggest that specific intracellular signaling pathways mediate specific events in DC lineage commitment.
1	Together	together	ADV	RB	_	_	_	_	SpaceAfter=No
2	,	,	PUNCT	,	_	_	_	_	_
3	these	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
4	findings	finding	NOUN	NNS	Number=Plur	_	_	_	_
5	demonstrate	demonstrate	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
6	that	that	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
7	cytokine	cytokine	NOUN	NN	Number=Sing	_	_	_	_
8	or	or	CCONJ	CC	_	_	_	_	_
9	phorbol	phorbol	NOUN	NN	Number=Sing	_	_	_	_
10	ester	ester	NOUN	NN	Number=Sing	_	_	_	_
11	stimulation	stimulation	NOUN	NN	Number=Sing	_	_	_	_
12	of	of	ADP	IN	_	_	_	_	_
13	KG1	KG1	PROPN	NNP	Number=Sing	_	_	_	_
14	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
15	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
16	model	model	NOUN	NN	Number=Sing	_	_	_	_
17	of	of	ADP	IN	_	_	_	_	_
18	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
19	CD34	CD34	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
20	+	+	SYM	SYM	_	_	_	_	_
21	HPC	HPC	PROPN	NNP	Number=Sing	_	_	_	_
22	to	to	ADP	IN	_	_	_	_	_
23	DC	DC	PROPN	NNP	Number=Sing	_	_	_	_
24	differentiation	differentiation	NOUN	NN	Number=Sing	_	_	_	_
25	and	and	CCONJ	CC	_	_	_	_	_
26	suggest	suggest	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
27	that	that	SCONJ	IN	_	_	_	_	_
28	specific	specific	ADJ	JJ	Degree=Pos	_	_	_	_
29	intracellular	intracellular	ADJ	JJ	Degree=Pos	_	_	_	_
30	signaling	signaling	NOUN	NN	Number=Sing	_	_	_	_
31	pathways	pathway	NOUN	NNS	Number=Plur	_	_	_	_
32	mediate	mediate	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
33	specific	specific	ADJ	JJ	Degree=Pos	_	_	_	_
34	events	event	NOUN	NNS	Number=Plur	_	_	_	_
35	in	in	ADP	IN	_	_	_	_	_
36	DC	DC	PROPN	NNP	Number=Sing	_	_	_	_
37	lineage	lineage	NOUN	NN	Number=Sing	_	_	_	_
38	commitment	commitment	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
39	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 633
# text = Document 003002219 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	003002219	003002219	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 634
# text = Induction of tyrosine phosphorylation and T-cell activation by vanadate peroxide, an inhibitor of protein tyrosine phosphatases.
1	Induction	Induction	NOUN	NN	Number=Sing	_	_	_	_
2	of	of	ADP	IN	_	_	_	_	_
3	tyrosine	tyrosine	NOUN	NN	Number=Sing	_	_	_	_
4	phosphorylation	phosphorylation	NOUN	NN	Number=Sing	_	_	_	_
5	and	and	CCONJ	CC	_	_	_	_	_
6	T-	T-	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
7	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
8	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
9	by	by	ADP	IN	_	_	_	_	_
10	vanadate	vanadate	ADJ	JJ	Degree=Pos	_	_	_	_
11	peroxide	peroxide	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
12	,	,	PUNCT	,	_	_	_	_	_
13	an	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
14	inhibitor	inhibitor	NOUN	NN	Number=Sing	_	_	_	_
15	of	of	ADP	IN	_	_	_	_	_
16	protein	protein	NOUN	NN	Number=Sing	_	_	_	_
17	tyrosine	tyrosine	NOUN	NN	Number=Sing	_	_	_	_
18	phosphatases	phosphatase	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
19	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 635
# text = Rapid tyrosine phosphorylation of key cellular proteins is a crucial event in the transduction of activation signals to T-lymphocytes.
1	Rapid	rapid	ADJ	JJ	Degree=Pos	_	_	_	_
2	tyrosine	tyrosine	NOUN	NN	Number=Sing	_	_	_	_
3	phosphorylation	phosphorylation	NOUN	NN	Number=Sing	_	_	_	_
4	of	of	ADP	IN	_	_	_	_	_
5	key	key	ADJ	JJ	Degree=Pos	_	_	_	_
6	cellular	cellular	ADJ	JJ	Degree=Pos	_	_	_	_
7	proteins	protein	NOUN	NNS	Number=Plur	_	_	_	_
8	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
9	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
10	crucial	crucial	ADJ	JJ	Degree=Pos	_	_	_	_
11	event	event	NOUN	NN	Number=Sing	_	_	_	_
12	in	in	ADP	IN	_	_	_	_	_
13	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
14	transduction	transduction	NOUN	NN	Number=Sing	_	_	_	_
15	of	of	ADP	IN	_	_	_	_	_
16	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
17	signals	signal	NOUN	NNS	Number=Plur	_	_	_	_
18	to	to	ADP	IN	_	_	_	_	_
19	T-	t-	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
20	lymphocytes	lymphocyte	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
21	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 636
# text = The regulatory role of protein tyrosine phosphatases (PTPases) in this process was explored by studying the effects of a powerful PTPase inhibitor, vanadate peroxide (pervanadate), on the activation cascade of Jurkat human leukaemic T-cells.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	regulatory	regulatory	ADJ	JJ	Degree=Pos	_	_	_	_
3	role	role	NOUN	NN	Number=Sing	_	_	_	_
4	of	of	ADP	IN	_	_	_	_	_
5	protein	protein	NOUN	NN	Number=Sing	_	_	_	_
6	tyrosine	tyrosine	NOUN	NN	Number=Sing	_	_	_	_
7	phosphatases	phosphatase	NOUN	NNS	Number=Plur	_	_	_	_
8	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
9	PTPases	PTPase	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
10	)	)	PUNCT	-RRB-	_	_	_	_	_
11	in	in	ADP	IN	_	_	_	_	_
12	this	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
13	process	process	NOUN	NN	Number=Sing	_	_	_	_
14	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
15	explored	explore	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
16	by	by	SCONJ	IN	_	_	_	_	_
17	studying	study	VERB	VBG	VerbForm=Ger	_	_	_	_
18	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
19	effects	effect	NOUN	NNS	Number=Plur	_	_	_	_
20	of	of	ADP	IN	_	_	_	_	_
21	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
22	powerful	powerful	ADJ	JJ	Degree=Pos	_	_	_	_
23	PTPase	PTPase	NOUN	NN	Number=Sing	_	_	_	_
24	inhibitor	inhibitor	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
25	,	,	PUNCT	,	_	_	_	_	_
26	vanadate	vanadate	NOUN	NN	Number=Sing	_	_	_	_
27	peroxide	peroxide	NOUN	NN	Number=Sing	_	_	_	_
28	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
29	pervanadate	pervanadate	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
30	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
31	,	,	PUNCT	,	_	_	_	_	_
32	on	on	ADP	IN	_	_	_	_	_
33	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
34	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
35	cascade	cascade	NOUN	NN	Number=Sing	_	_	_	_
36	of	of	ADP	IN	_	_	_	_	_
37	Jurkat	Jurkat	PROPN	NNP	Number=Sing	_	_	_	_
38	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
39	leukaemic	leukaemic	ADJ	JJ	Degree=Pos	_	_	_	_
40	T-	t-	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
41	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
42	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 637
# text = Pervanadate induced activation of the tyrosine kinases lck and fyn (4- and 3-fold respectively) and a dramatic increase in tyrosine phosphorylation of cellular proteins, notably phospholipase C gamma 1.
1	Pervanadate	Pervanadate	VERB	VB	Mood=Imp|VerbForm=Fin	_	_	_	_
2	induced	induce	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
3	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
4	of	of	ADP	IN	_	_	_	_	_
5	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
6	tyrosine	tyrosine	NOUN	NN	Number=Sing	_	_	_	_
7	kinases	kinase	NOUN	NNS	Number=Plur	_	_	_	_
8	lck	lck	NOUN	NN	Number=Sing	_	_	_	_
9	and	and	CCONJ	CC	_	_	_	_	_
10	fyn	fyn	NOUN	NN	Number=Sing	_	_	_	_
11	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
12	4	4	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
13	-	-	PUNCT	,	_	_	_	_	_
14	and	and	CCONJ	CC	_	_	_	_	_
15	3	3	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
16	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
17	fold	fold	NOUN	NN	Number=Sing	_	_	_	_
18	respectively	respectively	ADV	RB	_	_	_	_	SpaceAfter=No
19	)	)	PUNCT	-RRB-	_	_	_	_	_
20	and	and	CCONJ	CC	_	_	_	_	_
21	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
22	dramatic	dramatic	ADJ	JJ	Degree=Pos	_	_	_	_
23	increase	increase	NOUN	NN	Number=Sing	_	_	_	_
24	in	in	ADP	IN	_	_	_	_	_
25	tyrosine	tyrosine	NOUN	NN	Number=Sing	_	_	_	_
26	phosphorylation	phosphorylation	NOUN	NN	Number=Sing	_	_	_	_
27	of	of	ADP	IN	_	_	_	_	_
28	cellular	cellular	ADJ	JJ	Degree=Pos	_	_	_	_
29	proteins	protein	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
30	,	,	PUNCT	,	_	_	_	_	_
31	notably	notably	ADV	RB	_	_	_	_	_
32	phospholipase	phospholipase	NOUN	NN	Number=Sing	_	_	_	_
33	C	C	PROPN	NNP	Number=Sing	_	_	_	_
34	gamma	gamma	NOUN	NN	Number=Sing	_	_	_	_
35	1	1	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
36	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 638
# text = After this event, we observed a rise in intracellular Ca2+ concentration, corresponding to an influx.
1	After	after	ADP	IN	_	_	_	_	_
2	this	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
3	event	event	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
4	,	,	PUNCT	,	_	_	_	_	_
5	we	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
6	observed	observe	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
7	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
8	rise	rise	NOUN	NN	Number=Sing	_	_	_	_
9	in	in	ADP	IN	_	_	_	_	_
10	intracellular	intracellular	ADJ	JJ	Degree=Pos	_	_	_	_
11	Ca2	Ca2	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
12	+	+	SYM	SYM	_	_	_	_	_
13	concentration	concentration	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
14	,	,	PUNCT	,	_	_	_	_	_
15	corresponding	correspond	VERB	VBG	VerbForm=Ger	_	_	_	_
16	to	to	ADP	IN	_	_	_	_	_
17	an	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
18	influx	influx	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
19	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 639
# text = This effect required surface expression of the CD45 PTPase and was not observed in CD45-deficient variants of Jurkat cells.
1	This	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
2	effect	effect	NOUN	NN	Number=Sing	_	_	_	_
3	required	require	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
4	surface	surface	NOUN	NN	Number=Sing	_	_	_	_
5	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
6	of	of	ADP	IN	_	_	_	_	_
7	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
8	CD45	CD45	PROPN	NNP	Number=Sing	_	_	_	_
9	PTPase	PTPase	PROPN	NNP	Number=Sing	_	_	_	_
10	and	and	CCONJ	CC	_	_	_	_	_
11	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
12	not	not	PART	RB	_	_	_	_	_
13	observed	observe	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
14	in	in	ADP	IN	_	_	_	_	_
15	CD45	CD45	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
16	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
17	deficient	deficient	ADJ	JJ	Degree=Pos	_	_	_	_
18	variants	variant	NOUN	NNS	Number=Plur	_	_	_	_
19	of	of	ADP	IN	_	_	_	_	_
20	Jurkat	Jurkat	PROPN	NNP	Number=Sing	_	_	_	_
21	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
22	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 640
# text = In the CD45-negative variant, the effect of pervanadate on tyrosine phosphorylation was globally decreased and some phosphorylated substrates were specifically missing.
1	In	in	ADP	IN	_	_	_	_	_
2	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
3	CD45	Cd45	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
4	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
5	negative	negative	ADJ	JJ	Degree=Pos	_	_	_	_
6	variant	variant	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
7	,	,	PUNCT	,	_	_	_	_	_
8	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
9	effect	effect	NOUN	NN	Number=Sing	_	_	_	_
10	of	of	ADP	IN	_	_	_	_	_
11	pervanadate	pervanadate	NOUN	NN	Number=Sing	_	_	_	_
12	on	on	ADP	IN	_	_	_	_	_
13	tyrosine	tyrosine	NOUN	NN	Number=Sing	_	_	_	_
14	phosphorylation	phosphorylation	NOUN	NN	Number=Sing	_	_	_	_
15	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
16	globally	globally	ADV	RB	_	_	_	_	_
17	decreased	decrease	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
18	and	and	CCONJ	CC	_	_	_	_	_
19	some	some	DET	DT	_	_	_	_	_
20	phosphorylated	phosphorylate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
21	substrates	substrate	NOUN	NNS	Number=Plur	_	_	_	_
22	were	be	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
23	specifically	specifically	ADV	RB	_	_	_	_	_
24	missing	missing	VERB	VBG	Tense=Pres|VerbForm=Part	_	_	_	SpaceAfter=No
25	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 641
# text = Pervanadate also stimulated transcription of the c-fos gene and accumulation of its mRNA as well as several other hallmarks of T-lymphocyte activation such as surface expression of the CD69 antigen and the interleukin 2 receptor alpha-chain (CD25).
1	Pervanadate	Pervanadate	PROPN	NNP	Number=Sing	_	_	_	_
2	also	also	ADV	RB	_	_	_	_	_
3	stimulated	stimulate	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
4	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
5	of	of	ADP	IN	_	_	_	_	_
6	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
7	c	c	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
8	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
9	fos	fo	NOUN	NN	Number=Sing	_	_	_	_
10	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
11	and	and	CCONJ	CC	_	_	_	_	_
12	accumulation	accumulation	NOUN	NN	Number=Sing	_	_	_	_
13	of	of	ADP	IN	_	_	_	_	_
14	its	its	PRON	PRP$	Gender=Neut|Number=Sing|Person=3|Poss=Yes|PronType=Prs	_	_	_	_
15	mRNA	mRNA	NOUN	NN	Number=Sing	_	_	_	_
16	as	as	ADV	RB	_	_	_	_	_
17	well	well	ADV	RB	Degree=Pos	_	_	_	_
18	as	as	ADP	IN	_	_	_	_	_
19	several	several	ADJ	JJ	Degree=Pos	_	_	_	_
20	other	other	ADJ	JJ	Degree=Pos	_	_	_	_
21	hallmarks	hallmark	NOUN	NNS	Number=Plur	_	_	_	_
22	of	of	ADP	IN	_	_	_	_	_
23	T-	T-	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
24	lymphocyte	lymphocyte	NOUN	NN	Number=Sing	_	_	_	_
25	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
26	such	such	ADJ	JJ	Degree=Pos	_	_	_	_
27	as	as	ADP	IN	_	_	_	_	_
28	surface	surface	NOUN	NN	Number=Sing	_	_	_	_
29	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
30	of	of	ADP	IN	_	_	_	_	_
31	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
32	CD69	CD69	PROPN	NNP	Number=Sing	_	_	_	_
33	antigen	antigen	NOUN	NN	Number=Sing	_	_	_	_
34	and	and	CCONJ	CC	_	_	_	_	_
35	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
36	interleukin	interleukin	NOUN	NN	Number=Sing	_	_	_	_
37	2	2	NUM	CD	NumType=Card	_	_	_	_
38	receptor	receptor	NOUN	NN	Number=Sing	_	_	_	_
39	alpha-chain	alpha-chain	NOUN	NN	Number=Sing	_	_	_	_
40	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
41	CD25	CD25	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
42	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
43	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 642
# text = Pervanadate synergized with signals delivered by T-cell antigen receptor engagement or by a phorbol ester to induce interleukin 2 production.
1	Pervanadate	Pervanadate	NOUN	NN	Number=Sing	_	_	_	_
2	synergized	synergize	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
3	with	with	ADP	IN	_	_	_	_	_
4	signals	signal	NOUN	NNS	Number=Plur	_	_	_	_
5	delivered	deliver	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
6	by	by	ADP	IN	_	_	_	_	_
7	T-	T-	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
8	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
9	antigen	antigen	ADJ	JJ	Degree=Pos	_	_	_	_
10	receptor	receptor	NOUN	NN	Number=Sing	_	_	_	_
11	engagement	engagement	NOUN	NN	Number=Sing	_	_	_	_
12	or	or	CCONJ	CC	_	_	_	_	_
13	by	by	ADP	IN	_	_	_	_	_
14	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
15	phorbol	phorbol	ADJ	JJ	Degree=Pos	_	_	_	_
16	ester	ester	NOUN	NN	Number=Sing	_	_	_	_
17	to	to	PART	TO	_	_	_	_	_
18	induce	induce	VERB	VB	VerbForm=Inf	_	_	_	_
19	interleukin	interleukin	ADV	RB	_	_	_	_	_
20	2	2	NUM	CD	NumType=Card	_	_	_	_
21	production	production	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
22	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 643
# text = Pervanadate activated NF-kappa B, as shown by an increase in DNA-binding activity of this transcription factor.
1	Pervanadate	Pervanadate	PROPN	NNP	Number=Sing	_	_	_	_
2	activated	activate	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
3	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
4	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
5	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_
6	B	b	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
7	,	,	PUNCT	,	_	_	_	_	_
8	as	as	SCONJ	IN	_	_	_	_	_
9	shown	show	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
10	by	by	ADP	IN	_	_	_	_	_
11	an	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
12	increase	increase	NOUN	NN	Number=Sing	_	_	_	_
13	in	in	ADP	IN	_	_	_	_	_
14	DNA	dna	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
15	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
16	binding	binding	VERB	VBG	VerbForm=Ger	_	_	_	_
17	activity	activity	NOUN	NN	Number=Sing	_	_	_	_
18	of	of	ADP	IN	_	_	_	_	_
19	this	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
20	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
21	factor	factor	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
22	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 644
# text = We thus conclude that PTPases play a crucial role in the negative regulation of signal transduction culminating in T-lymphocyte activation.
1	We	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
2	thus	thus	ADV	RB	_	_	_	_	_
3	conclude	conclude	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
4	that	that	SCONJ	IN	_	_	_	_	_
5	PTPases	PTPase	PROPN	NNPS	Number=Plur	_	_	_	_
6	play	play	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
7	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
8	crucial	crucial	ADJ	JJ	Degree=Pos	_	_	_	_
9	role	role	NOUN	NN	Number=Sing	_	_	_	_
10	in	in	ADP	IN	_	_	_	_	_
11	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
12	negative	negative	ADJ	JJ	Degree=Pos	_	_	_	_
13	regulation	regulation	NOUN	NN	Number=Sing	_	_	_	_
14	of	of	ADP	IN	_	_	_	_	_
15	signal	signal	NOUN	NN	Number=Sing	_	_	_	_
16	transduction	transduction	NOUN	NN	Number=Sing	_	_	_	_
17	culminating	culminat	VERB	VBG	VerbForm=Ger	_	_	_	_
18	in	in	ADP	IN	_	_	_	_	_
19	T-	t-	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
20	lymphocyte	lymphocyte	NOUN	NN	Number=Sing	_	_	_	_
21	activation	activation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
22	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 645
# text = Moreover, induction of tyrosine phosphorylation appears sufficient per se to initiate a complete activation programme.
1	Moreover	moreover	ADV	RB	_	_	_	_	SpaceAfter=No
2	,	,	PUNCT	,	_	_	_	_	_
3	induction	induction	NOUN	NN	Number=Sing	_	_	_	_
4	of	of	ADP	IN	_	_	_	_	_
5	tyrosine	tyrosine	NOUN	NN	Number=Sing	_	_	_	_
6	phosphorylation	phosphorylation	NOUN	NN	Number=Sing	_	_	_	_
7	appears	appear	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
8	sufficient	sufficient	ADJ	JJ	Degree=Pos	_	_	_	_
9	per	per	ADP	IN	_	_	_	_	_
10	se	se	NOUN	NN	Number=Sing	_	_	_	_
11	to	to	PART	TO	_	_	_	_	_
12	initiate	initiate	VERB	VB	VerbForm=Inf	_	_	_	_
13	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
14	complete	complete	ADJ	JJ	Degree=Pos	_	_	_	_
15	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
16	programme	programme	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
17	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 646
# text = Document 003002221 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	003002221	003002221	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 647
# text = Relationship between IkappaBalpha constitutive expression, TNFalpha synthesis, and apoptosis in EBV-infected lymphoblastoid cells.
1	Relationship	relationship	NOUN	NN	Number=Sing	_	_	_	_
2	between	between	ADP	IN	_	_	_	_	_
3	IkappaBalpha	IkappaBalpha	PROPN	NNP	Number=Sing	_	_	_	_
4	constitutive	constitutive	ADJ	JJ	Degree=Pos	_	_	_	_
5	expression	expression	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
6	,	,	PUNCT	,	_	_	_	_	_
7	TNFalpha	TNFalpha	PROPN	NNP	Number=Sing	_	_	_	_
8	synthesis	synthesis	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
9	,	,	PUNCT	,	_	_	_	_	_
10	and	and	CCONJ	CC	_	_	_	_	_
11	apoptosis	apoptosis	PRON	DT	Number=Sing|PronType=Dem	_	_	_	_
12	in	in	ADP	IN	_	_	_	_	_
13	EBV	EBV	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
14	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
15	infected	infect	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
16	lymphoblastoid	lymphoblastoid	ADJ	JJ	Degree=Pos	_	_	_	_
17	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
18	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 648
# text = In order to understand the role of NF-kappaB in EBV transformation we have established stably transfected IkappaBalpha into lymphoblastoid cells.
1	In	in	ADP	IN	_	_	_	_	_
2	order	order	NOUN	NN	Number=Sing	_	_	_	_
3	to	to	PART	TO	_	_	_	_	_
4	understand	understand	VERB	VB	VerbForm=Inf	_	_	_	_
5	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
6	role	role	NOUN	NN	Number=Sing	_	_	_	_
7	of	of	ADP	IN	_	_	_	_	_
8	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
9	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
10	kappaB	kappaB	PROPN	NNP	Number=Sing	_	_	_	_
11	in	in	ADP	IN	_	_	_	_	_
12	EBV	EBV	PROPN	NNP	Number=Sing	_	_	_	_
13	transformation	transformation	NOUN	NN	Number=Sing	_	_	_	_
14	we	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
15	have	have	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
16	established	establish	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
17	stably	stably	ADV	RB	_	_	_	_	_
18	transfected	transfect	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
19	IkappaBalpha	IkappaBalpha	PROPN	NNP	Number=Sing	_	_	_	_
20	into	into	ADP	IN	_	_	_	_	_
21	lymphoblastoid	lymphoblastoid	ADJ	JJ	Degree=Pos	_	_	_	_
22	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
23	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 649
# text = Two clones were obtained in which the loss of NF-kappaB binding activity correlated with the constitutive expression of the transgenic IkappaBalpha.
1	Two	two	NUM	CD	NumType=Card	_	_	_	_
2	clones	clone	NOUN	NNS	Number=Plur	_	_	_	_
3	were	be	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
4	obtained	obtain	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
5	in	in	ADP	IN	_	_	_	_	_
6	which	which	PRON	WDT	PronType=Rel	_	_	_	_
7	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
8	loss	loss	NOUN	NN	Number=Sing	_	_	_	_
9	of	of	ADP	IN	_	_	_	_	_
10	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
11	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
12	kappaB	kappaB	PROPN	NNP	Number=Sing	_	_	_	_
13	binding	bind	VERB	VBG	VerbForm=Ger	_	_	_	_
14	activity	activity	NOUN	NN	Number=Sing	_	_	_	_
15	correlated	correlate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
16	with	with	ADP	IN	_	_	_	_	_
17	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
18	constitutive	constitutive	ADJ	JJ	Degree=Pos	_	_	_	_
19	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
20	of	of	ADP	IN	_	_	_	_	_
21	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
22	transgenic	transgenic	ADJ	JJ	Degree=Pos	_	_	_	_
23	IkappaBalpha	IkappaBalpha	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
24	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 650
# text = Protein latency expression was determined by immunocytochemistry.
1	Protein	protein	NOUN	NN	Number=Sing	_	_	_	_
2	latency	latency	NOUN	NN	Number=Sing	_	_	_	_
3	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
4	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
5	determined	determine	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
6	by	by	ADP	IN	_	_	_	_	_
7	immunocytochemistry	immunocytochemistry	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
8	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 651
# text = Expression of surface markers, intracytoplasmic content of cytokines cell cycle analysis after BrdU incorporation and DNA staining with propidium iodide were studied by flow cytometry.
1	Expression	expression	NOUN	NN	Number=Sing	_	_	_	_
2	of	of	ADP	IN	_	_	_	_	_
3	surface	surface	NOUN	NN	Number=Sing	_	_	_	_
4	markers	marker	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
5	,	,	PUNCT	,	_	_	_	_	_
6	intracytoplasmic	intracytoplasmic	ADJ	JJ	Degree=Pos	_	_	_	_
7	content	content	NOUN	NN	Number=Sing	_	_	_	_
8	of	of	ADP	IN	_	_	_	_	_
9	cytokines	cytokine	NOUN	NNS	Number=Plur	_	_	_	_
10	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
11	cycle	cycle	NOUN	NN	Number=Sing	_	_	_	_
12	analysis	analysis	NOUN	NN	Number=Sing	_	_	_	_
13	after	after	ADP	IN	_	_	_	_	_
14	BrdU	Brdu	PROPN	NNP	Number=Sing	_	_	_	_
15	incorporation	incorporation	NOUN	NN	Number=Sing	_	_	_	_
16	and	and	CCONJ	CC	_	_	_	_	_
17	DNA	dna	NOUN	NN	Number=Sing	_	_	_	_
18	staining	stain	VERB	VBG	VerbForm=Ger	_	_	_	_
19	with	with	ADP	IN	_	_	_	_	_
20	propidium	propidium	NOUN	NN	Number=Sing	_	_	_	_
21	iodide	iodide	NOUN	NN	Number=Sing	_	_	_	_
22	were	be	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
23	studied	study	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
24	by	by	ADP	IN	_	_	_	_	_
25	flow	flow	NOUN	NN	Number=Sing	_	_	_	_
26	cytometry	cytometry	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
27	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 652
# text = Percentage of apoptotic cells was determined by in-situ labelling of DNA strand breaks.
1	Percentage	percentage	NOUN	NN	Number=Sing	_	_	_	_
2	of	of	ADP	IN	_	_	_	_	_
3	apoptotic	apoptotic	ADJ	JJ	Degree=Pos	_	_	_	_
4	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
5	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
6	determined	determine	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
7	by	by	ADP	IN	_	_	_	_	_
8	in	in	ADP	IN	_	_	_	_	SpaceAfter=No
9	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
10	situ	situ	NOUN	NN	Number=Sing	_	_	_	_
11	labelling	labelling	NOUN	NN	Number=Sing	_	_	_	_
12	of	of	ADP	IN	_	_	_	_	_
13	DNA	dna	NOUN	NN	Number=Sing	_	_	_	_
14	strand	strand	NOUN	NN	Number=Sing	_	_	_	_
15	breaks	break	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
16	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 653
# text = No significative changes in EBV latency nor in cell surface marker expression was found.
1	No	no	DET	DT	_	_	_	_	_
2	significative	significative	ADJ	JJ	Degree=Pos	_	_	_	_
3	changes	change	NOUN	NNS	Number=Plur	_	_	_	_
4	in	in	ADP	IN	_	_	_	_	_
5	EBV	EBV	PROPN	NNP	Number=Sing	_	_	_	_
6	latency	latency	PROPN	NNP	Number=Sing	_	_	_	_
7	nor	nor	CCONJ	CC	_	_	_	_	_
8	in	in	ADP	IN	_	_	_	_	_
9	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
10	surface	surface	NOUN	NN	Number=Sing	_	_	_	_
11	marker	marker	NOUN	NN	Number=Sing	_	_	_	_
12	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
13	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
14	found	find	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	SpaceAfter=No
15	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 654
# text = In contrast, intracytoplasmic TNFalpha levels were strongly reduced in transfected clones.
1	In	in	ADP	IN	_	_	_	_	_
2	contrast	contrast	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
3	,	,	PUNCT	,	_	_	_	_	_
4	intracytoplasmic	intracytoplasmic	ADJ	JJ	Degree=Pos	_	_	_	_
5	TNFalpha	TNFalpha	PROPN	NNP	Number=Sing	_	_	_	_
6	levels	level	NOUN	NNS	Number=Plur	_	_	_	_
7	were	be	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
8	strongly	strongly	ADV	RB	_	_	_	_	_
9	reduced	reduce	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
10	in	in	ADP	IN	_	_	_	_	_
11	transfected	transfect	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
12	clones	clone	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
13	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 655
# text = Furthermore, 30% of IkappaBalpha transfected cells were apoptotic after 8 h of TNFalpha treatment.
1	Furthermore	furthermore	ADV	RB	_	_	_	_	SpaceAfter=No
2	,	,	PUNCT	,	_	_	_	_	_
3	30	30	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
4	%	%	SYM	NN	Number=Sing	_	_	_	_
5	of	of	ADP	IN	_	_	_	_	_
6	IkappaBalpha	IkappaBalpha	PROPN	NNP	Number=Sing	_	_	_	_
7	transfected	transfect	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
8	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
9	were	be	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
10	apoptotic	apoptotic	ADJ	JJ	Degree=Pos	_	_	_	_
11	after	after	ADP	IN	_	_	_	_	_
12	8	8	NUM	CD	NumType=Card	_	_	_	_
13	h	h	NOUN	NN	Number=Sing	_	_	_	_
14	of	of	ADP	IN	_	_	_	_	_
15	TNFalpha	TNFalpha	PROPN	NNP	Number=Sing	_	_	_	_
16	treatment	treatment	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
17	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 656
# text = This correlated with a strong reduction of BrdU incorporation after 24 h of TNFalpha treatment.
1	This	this	PRON	DT	Number=Sing|PronType=Dem	_	_	_	_
2	correlated	correlate	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
3	with	with	ADP	IN	_	_	_	_	_
4	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
5	strong	strong	ADJ	JJ	Degree=Pos	_	_	_	_
6	reduction	reduction	NOUN	NN	Number=Sing	_	_	_	_
7	of	of	ADP	IN	_	_	_	_	_
8	BrdU	BrdU	PROPN	NNP	Number=Sing	_	_	_	_
9	incorporation	incorporation	NOUN	NN	Number=Sing	_	_	_	_
10	after	after	ADP	IN	_	_	_	_	_
11	24	24	NUM	CD	NumType=Card	_	_	_	_
12	h	h	NOUN	NN	Number=Sing	_	_	_	_
13	of	of	ADP	IN	_	_	_	_	_
14	TNFalpha	TNFalpha	PROPN	NNP	Number=Sing	_	_	_	_
15	treatment	treatment	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
16	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 657
# text = No effect was seen with non transfected cells or with cells transfected with a control plasmid.
1	No	no	DET	DT	_	_	_	_	_
2	effect	effect	NOUN	NN	Number=Sing	_	_	_	_
3	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
4	seen	see	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
5	with	with	ADP	IN	_	_	_	_	_
6	non	non	X	AFX	_	_	_	_	_
7	transfected	transfect	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
8	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
9	or	or	CCONJ	CC	_	_	_	_	_
10	with	with	ADP	IN	_	_	_	_	_
11	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
12	transfected	transfect	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
13	with	with	ADP	IN	_	_	_	_	_
14	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
15	control	control	NOUN	NN	Number=Sing	_	_	_	_
16	plasmid	plasmid	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
17	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 658
# text = Our results suggest that the TNFalpha gene could be one of the targets of NF-kappaB in EBV infected cells and that NF-kappaB protects EBV-infected cells from apoptosis induced by TNFalpha, which may favour the proliferative effect of this cytokine.
1	Our	we	PRON	PRP$	Number=Plur|Person=1|Poss=Yes|PronType=Prs	_	_	_	_
2	results	result	NOUN	NNS	Number=Plur	_	_	_	_
3	suggest	suggest	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
4	that	that	SCONJ	IN	_	_	_	_	_
5	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
6	TNFalpha	TNFalpha	NOUN	NN	Number=Sing	_	_	_	_
7	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
8	could	could	AUX	MD	VerbForm=Fin	_	_	_	_
9	be	be	AUX	VB	VerbForm=Inf	_	_	_	_
10	one	one	NUM	CD	NumType=Card	_	_	_	_
11	of	of	ADP	IN	_	_	_	_	_
12	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
13	targets	target	NOUN	NNS	Number=Plur	_	_	_	_
14	of	of	ADP	IN	_	_	_	_	_
15	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
16	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
17	kappaB	kappaB	PROPN	NNP	Number=Sing	_	_	_	_
18	in	in	ADP	IN	_	_	_	_	_
19	EBV	EBV	PROPN	NNP	Number=Sing	_	_	_	_
20	infected	infect	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
21	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
22	and	and	CCONJ	CC	_	_	_	_	_
23	that	that	SCONJ	IN	_	_	_	_	_
24	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
25	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
26	kappaB	kappaB	PROPN	NNP	Number=Sing	_	_	_	_
27	protects	protects	NOUN	NNS	Number=Plur	_	_	_	_
28	EBV	haEbve	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
29	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
30	infected	infect	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
31	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
32	from	from	ADP	IN	_	_	_	_	_
33	apoptosis	apoptosis	NOUN	NN	Number=Sing	_	_	_	_
34	induced	induce	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
35	by	by	ADP	IN	_	_	_	_	_
36	TNFalpha	TNFalpha	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
37	,	,	PUNCT	,	_	_	_	_	_
38	which	which	PRON	WDT	PronType=Rel	_	_	_	_
39	may	may	AUX	MD	VerbForm=Fin	_	_	_	_
40	favour	favour	VERB	VB	VerbForm=Inf	_	_	_	_
41	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
42	proliferative	proliferative	ADJ	JJ	Degree=Pos	_	_	_	_
43	effect	effect	NOUN	NN	Number=Sing	_	_	_	_
44	of	of	ADP	IN	_	_	_	_	_
45	this	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
46	cytokine	cytokine	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
47	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 659
# text = Document 003002228 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	003002228	003002228	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 660
# text = Involvement of the N-terminal region of the human mineralocorticoid receptor hormone-binding domain in agonist and antagonist binding as revealed by a new monoclonal antibody.
1	Involvement	involvement	NOUN	NN	Number=Sing	_	_	_	_
2	of	of	ADP	IN	_	_	_	_	_
3	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
4	N-	N-	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
5	terminal	terminal	NOUN	NN	Number=Sing	_	_	_	_
6	region	region	NOUN	NN	Number=Sing	_	_	_	_
7	of	of	ADP	IN	_	_	_	_	_
8	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
9	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
10	mineralocorticoid	mineralocorticoid	NOUN	NN	Number=Sing	_	_	_	_
11	receptor	receptor	NOUN	NN	Number=Sing	_	_	_	_
12	hormone	hormone	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
13	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
14	binding	bind	VERB	VBG	VerbForm=Ger	_	_	_	_
15	domain	domain	NOUN	NN	Number=Sing	_	_	_	_
16	in	in	ADP	IN	_	_	_	_	_
17	agonist	agonist	NOUN	NN	Number=Sing	_	_	_	_
18	and	and	CCONJ	CC	_	_	_	_	_
19	antagonist	antagonist	NOUN	NN	Number=Sing	_	_	_	_
20	binding	bind	VERB	VBG	VerbForm=Ger	_	_	_	_
21	as	as	SCONJ	IN	_	_	_	_	_
22	revealed	reveal	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
23	by	by	ADP	IN	_	_	_	_	_
24	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
25	new	new	ADJ	JJ	Degree=Pos	_	_	_	_
26	monoclonal	monoclonal	ADJ	JJ	Degree=Pos	_	_	_	_
27	antibody	antibody	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
28	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 661
# text = To gain a better understanding of the mechanism of binding to the human mineralocorticoid receptor (hMR), we developed a new monoclonal antibody (mAb) raised against the hormone-binding domain (HBD).
1	To	to	PART	TO	_	_	_	_	_
2	gain	gain	VERB	VB	VerbForm=Inf	_	_	_	_
3	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
4	better	better	ADJ	JJR	Degree=Cmp	_	_	_	_
5	understanding	understanding	NOUN	NN	Number=Sing	_	_	_	_
6	of	of	ADP	IN	_	_	_	_	_
7	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
8	mechanism	mechanism	NOUN	NN	Number=Sing	_	_	_	_
9	of	of	SCONJ	IN	_	_	_	_	_
10	binding	bind	VERB	VBG	VerbForm=Ger	_	_	_	_
11	to	to	ADP	IN	_	_	_	_	_
12	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
13	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
14	mineralocorticoid	mineralocorticoid	NOUN	NN	Number=Sing	_	_	_	_
15	receptor	receptor	NOUN	NN	Number=Sing	_	_	_	_
16	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
17	hMR	hMR	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
18	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
19	,	,	PUNCT	,	_	_	_	_	_
20	we	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
21	developed	develop	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
22	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
23	new	new	ADJ	JJ	Degree=Pos	_	_	_	_
24	monoclonal	monoclonal	ADJ	JJ	Degree=Pos	_	_	_	_
25	antibody	antibody	NOUN	NN	Number=Sing	_	_	_	_
26	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
27	mAb	mAb	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
28	)	)	PUNCT	-RRB-	_	_	_	_	_
29	raised	raise	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
30	against	against	ADP	IN	_	_	_	_	_
31	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
32	hormone	hormone	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
33	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
34	binding	binding	VERB	VBG	VerbForm=Ger	_	_	_	_
35	domain	domain	NOUN	NN	Number=Sing	_	_	_	_
36	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
37	HBD	HBD	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
38	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
39	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 662
# text = For this purpose, mice were immunized with a fusion protein including the sequence Thr729-Lys984 of hMR.
1	For	for	ADP	IN	_	_	_	_	_
2	this	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
3	purpose	purpose	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
4	,	,	PUNCT	,	_	_	_	_	_
5	mice	mouse	NOUN	NNS	Number=Plur	_	_	_	_
6	were	be	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
7	immunized	immunize	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
8	with	with	ADP	IN	_	_	_	_	_
9	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
10	fusion	fusion	NOUN	NN	Number=Sing	_	_	_	_
11	protein	protein	NOUN	NN	Number=Sing	_	_	_	_
12	including	include	VERB	VBG	VerbForm=Ger	_	_	_	_
13	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
14	sequence	sequence	NOUN	NN	Number=Sing	_	_	_	_
15	Thr729	Thr729	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
16	-	-	PUNCT	:	_	_	_	_	SpaceAfter=No
17	Lys984	lys984	NOUN	NN	Number=Sing	_	_	_	_
18	of	of	ADP	IN	_	_	_	_	_
19	hMR	hMR	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
20	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 663
# text = After ELISA screening, mAb 18C7 was selected for its specificity towards the HBD.
1	After	after	SCONJ	IN	_	_	_	_	_
2	ELISA	ELISA	PROPN	NNP	Number=Sing	_	_	_	_
3	screening	scree	VERB	VBG	VerbForm=Ger	_	_	_	SpaceAfter=No
4	,	,	PUNCT	,	_	_	_	_	_
5	mAb	mAb	PROPN	NNP	Number=Sing	_	_	_	_
6	18C7	18C7	NOUN	NN	Number=Sing	_	_	_	_
7	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
8	selected	select	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
9	for	for	ADP	IN	_	_	_	_	_
10	its	its	PRON	PRP$	Gender=Neut|Number=Sing|Person=3|Poss=Yes|PronType=Prs	_	_	_	_
11	specificity	specificity	NOUN	NN	Number=Sing	_	_	_	_
12	towards	towards	ADP	IN	_	_	_	_	_
13	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
14	HBD	hbd	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
15	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 664
# text = This antibody recognized both the denatured and native MR forms, as well as the hetero-oligomeric MR form and the transformed MR state.
1	This	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
2	antibody	antibody	NOUN	NN	Number=Sing	_	_	_	_
3	recognized	recognize	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
4	both	both	CCONJ	CC	_	_	_	_	_
5	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
6	denatured	denatured	ADJ	JJ	Degree=Pos	_	_	_	_
7	and	and	CCONJ	CC	_	_	_	_	_
8	native	native	ADJ	JJ	Degree=Pos	_	_	_	_
9	MR	mr	NOUN	NN	Number=Sing	_	_	_	_
10	forms	form	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
11	,	,	PUNCT	,	_	_	_	_	_
12	as	as	ADV	RB	_	_	_	_	_
13	well	well	ADV	RB	Degree=Pos	_	_	_	_
14	as	as	ADP	IN	_	_	_	_	_
15	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
16	hetero	hetero	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
17	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
18	oligomeric	oligomeric	ADJ	JJ	Degree=Pos	_	_	_	_
19	MR	mr	NOUN	NN	Number=Sing	_	_	_	_
20	form	form	NOUN	NN	Number=Sing	_	_	_	_
21	and	and	CCONJ	CC	_	_	_	_	_
22	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
23	transformed	transform	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
24	MR	mr	NOUN	NN	Number=Sing	_	_	_	_
25	state	state	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
26	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 665
# text = By using several HBD subfragments, the mAb 18C7 epitope was located in the N-terminal region of the HBD from Thr729 to Leu765.
1	By	by	SCONJ	IN	_	_	_	_	_
2	using	use	VERB	VBG	VerbForm=Ger	_	_	_	_
3	several	several	ADJ	JJ	Degree=Pos	_	_	_	_
4	HBD	hbd	NOUN	NN	Number=Sing	_	_	_	_
5	subfragments	subfragment	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
6	,	,	PUNCT	,	_	_	_	_	_
7	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
8	mAb	mAb	PROPN	NNP	Number=Sing	_	_	_	_
9	18C7	18C7	NUM	CD	NumType=Card	_	_	_	_
10	epitope	epitope	NOUN	NN	Number=Sing	_	_	_	_
11	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
12	located	locate	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
13	in	in	ADP	IN	_	_	_	_	_
14	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
15	N-	N-	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
16	terminal	terminal	NOUN	NN	Number=Sing	_	_	_	_
17	region	region	NOUN	NN	Number=Sing	_	_	_	_
18	of	of	ADP	IN	_	_	_	_	_
19	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
20	HBD	hbd	PROPN	NNP	Number=Sing	_	_	_	_
21	from	from	ADP	IN	_	_	_	_	_
22	Thr729	Thr729	NUM	CD	NumType=Card	_	_	_	_
23	to	to	ADP	IN	_	_	_	_	_
24	Leu765	Leu765	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
25	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 666
# text = We then studied the effect of the antibody on aldosterone and progesterone binding to the hMR.
1	We	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
2	then	then	ADV	RB	PronType=Dem	_	_	_	_
3	studied	study	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
4	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
5	effect	effect	NOUN	NN	Number=Sing	_	_	_	_
6	of	of	ADP	IN	_	_	_	_	_
7	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
8	antibody	antibody	NOUN	NN	Number=Sing	_	_	_	_
9	on	on	ADP	IN	_	_	_	_	_
10	aldosterone	aldosterone	NOUN	NN	Number=Sing	_	_	_	_
11	and	and	CCONJ	CC	_	_	_	_	_
12	progesterone	progesterone	NOUN	NN	Number=Sing	_	_	_	_
13	binding	bind	VERB	VBG	VerbForm=Ger	_	_	_	_
14	to	to	ADP	IN	_	_	_	_	_
15	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
16	hMR	hmr	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
17	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 667
# text = When 18C7 was incubated with liganded MR, it was able to partly displace (20%) the hormone from its binding site.
1	When	when	ADV	WRB	PronType=Int	_	_	_	_
2	18C7	18C7	NUM	CD	NumType=Card	_	_	_	_
3	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
4	incubated	incubate	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
5	with	with	ADP	IN	_	_	_	_	_
6	liganded	ligand	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
7	MR	mr	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
8	,	,	PUNCT	,	_	_	_	_	_
9	it	it	PRON	PRP	Case=Nom|Gender=Neut|Number=Sing|Person=3|PronType=Prs	_	_	_	_
10	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
11	able	able	ADJ	JJ	Degree=Pos	_	_	_	_
12	to	to	PART	TO	_	_	_	_	_
13	partly	partly	VERB	VB	VerbForm=Inf	_	_	_	_
14	displace	displace	NOUN	NN	Number=Sing	_	_	_	_
15	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
16	20	20	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
17	%	%	SYM	NN	Number=Sing	_	_	_	SpaceAfter=No
18	)	)	PUNCT	-RRB-	_	_	_	_	_
19	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
20	hormone	hormone	NOUN	NN	Number=Sing	_	_	_	_
21	from	from	ADP	IN	_	_	_	_	_
22	its	its	PRON	PRP$	Gender=Neut|Number=Sing|Person=3|Poss=Yes|PronType=Prs	_	_	_	_
23	binding	bind	VERB	VBG	VerbForm=Ger	_	_	_	_
24	site	site	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
25	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 668
# text = When 18C7 was incubated with MR before aldosterone or progesterone, the antibody inhibited 75-80% of the binding.
1	When	when	ADV	WRB	PronType=Int	_	_	_	_
2	18C7	18C7	NUM	CD	NumType=Card	_	_	_	_
3	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
4	incubated	incubate	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
5	with	with	ADP	IN	_	_	_	_	_
6	MR	mr	PROPN	NNP	Number=Sing	_	_	_	_
7	before	before	ADP	IN	_	_	_	_	_
8	aldosterone	aldosterone	NOUN	NN	Number=Sing	_	_	_	_
9	or	or	CCONJ	CC	_	_	_	_	_
10	progesterone	progesterone	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
11	,	,	PUNCT	,	_	_	_	_	_
12	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
13	antibody	antibody	NOUN	NN	Number=Sing	_	_	_	_
14	inhibited	inhibit	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
15	75	75	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
16	-	-	SYM	SYM	_	_	_	_	SpaceAfter=No
17	80	80	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
18	%	%	SYM	NN	Number=Sing	_	_	_	_
19	of	of	ADP	IN	_	_	_	_	_
20	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
21	binding	binding	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
22	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 669
# text = The effect of 18C7 on the binding was similar with both hormones.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	effect	effect	NOUN	NN	Number=Sing	_	_	_	_
3	of	of	ADP	IN	_	_	_	_	_
4	18C7	18C7	NUM	CD	NumType=Card	_	_	_	_
5	on	on	ADP	IN	_	_	_	_	_
6	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
7	binding	binding	NOUN	NN	Number=Sing	_	_	_	_
8	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
9	similar	similar	ADJ	JJ	Degree=Pos	_	_	_	_
10	with	with	ADP	IN	_	_	_	_	_
11	both	both	DET	DT	_	_	_	_	_
12	hormones	hormone	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
13	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 670
# text = A sucrose gradient analysis indicated the simultaneous presence of two kinds of receptor complexes: the steroid-MR complex and the antibody-MR complex.
1	A	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
2	sucrose	sucrose	NOUN	NN	Number=Sing	_	_	_	_
3	gradient	gradient	NOUN	NN	Number=Sing	_	_	_	_
4	analysis	analysis	NOUN	NN	Number=Sing	_	_	_	_
5	indicated	indicate	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
6	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
7	simultaneous	simultaneous	ADJ	JJ	Degree=Pos	_	_	_	_
8	presence	presence	NOUN	NN	Number=Sing	_	_	_	_
9	of	of	ADP	IN	_	_	_	_	_
10	two	two	NUM	CD	NumType=Card	_	_	_	_
11	kinds	kind	NOUN	NNS	Number=Plur	_	_	_	_
12	of	of	ADP	IN	_	_	_	_	_
13	receptor	receptor	NOUN	NN	Number=Sing	_	_	_	_
14	complexes	complex	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
15	:	:	PUNCT	:	_	_	_	_	_
16	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
17	steroid	steroid	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
18	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
19	MR	mr	NOUN	NN	Number=Sing	_	_	_	_
20	complex	complex	NOUN	NN	Number=Sing	_	_	_	_
21	and	and	CCONJ	CC	_	_	_	_	_
22	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
23	antibody	antibody	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
24	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
25	MR	mr	NOUN	NN	Number=Sing	_	_	_	_
26	complex	complex	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
27	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 671
# text = After its associated proteins, especially the heat-shock protein hsp90, had been cross-linked with the hMR by dimethylpimelimidate, 18C7 was still able to react with the receptor.
1	After	after	SCONJ	IN	_	_	_	_	_
2	it	it	PRON	PRP	Case=Nom|Gender=Neut|Number=Sing|Person=3|PronType=Prs	_	_	_	SpaceAfter=No
3	s	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
4	associated	associate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
5	proteins	protein	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
6	,	,	PUNCT	,	_	_	_	_	_
7	especially	especially	ADV	RB	_	_	_	_	_
8	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
9	heat	heat	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
10	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
11	shock	shock	NOUN	NN	Number=Sing	_	_	_	_
12	protein	protein	NOUN	NN	Number=Sing	_	_	_	_
13	hsp90	hsp90	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
14	,	,	PUNCT	,	_	_	_	_	_
15	had	have	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
16	been	be	AUX	VBN	Tense=Past|VerbForm=Part	_	_	_	_
17	cross	cross	ADV	RB	_	_	_	_	SpaceAfter=No
18	-linked	-linked	ADJ	JJ	Degree=Pos	_	_	_	_
19	with	with	ADP	IN	_	_	_	_	_
20	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
21	hMR	hmr	NOUN	NN	Number=Sing	_	_	_	_
22	by	by	ADP	IN	_	_	_	_	_
23	dimethylpimelimidate	dimethylpimelimidate	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
24	,	,	PUNCT	,	_	_	_	_	_
25	18C7	18C7	NOUN	NN	Number=Sing	_	_	_	_
26	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
27	still	still	ADV	RB	_	_	_	_	_
28	able	able	ADJ	JJ	Degree=Pos	_	_	_	_
29	to	to	PART	TO	_	_	_	_	_
30	react	react	VERB	VB	VerbForm=Inf	_	_	_	_
31	with	with	ADP	IN	_	_	_	_	_
32	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
33	receptor	receptor	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
34	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 672
# text = Our results indicated that the epitope recognized by 18C7 was directly implicated in hormone binding.
1	Our	we	PRON	PRP$	Number=Plur|Person=1|Poss=Yes|PronType=Prs	_	_	_	_
2	results	result	NOUN	NNS	Number=Plur	_	_	_	_
3	indicated	indicate	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
4	that	that	SCONJ	IN	_	_	_	_	_
5	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
6	epitope	epitope	NOUN	NN	Number=Sing	_	_	_	_
7	recognized	recognize	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
8	by	by	ADP	IN	_	_	_	_	_
9	18C7	18C7	NOUN	NN	Number=Sing	_	_	_	_
10	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
11	directly	directly	ADV	RB	_	_	_	_	_
12	implicated	implicate	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
13	in	in	ADP	IN	_	_	_	_	_
14	hormone	hormone	NOUN	NN	Number=Sing	_	_	_	_
15	binding	binding	VERB	VBG	VerbForm=Ger	_	_	_	SpaceAfter=No
16	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 673
# text = The lack of steroid binding of HBD mutants with the Thr729-Leu765 sequence deleted [Jalaguier, Mesnier, Leger and Auzou (1996) J.Steroid Biochem.Mol.Biol.57, 43-50] supports this hypothesis.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	lack	lack	NOUN	NN	Number=Sing	_	_	_	_
3	of	of	ADP	IN	_	_	_	_	_
4	steroid	steroid	NOUN	NN	Number=Sing	_	_	_	_
5	binding	binding	VERB	VBG	VerbForm=Ger	_	_	_	_
6	of	of	ADP	IN	_	_	_	_	_
7	HBD	Hbd	PROPN	NNP	Number=Sing	_	_	_	_
8	mutants	mutant	NOUN	NNS	Number=Plur	_	_	_	_
9	with	with	ADP	IN	_	_	_	_	_
10	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
11	Thr729	Thr729	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
12	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
13	Leu765	Leu765	PROPN	NNP	Number=Sing	_	_	_	_
14	sequence	sequence	NOUN	NN	Number=Sing	_	_	_	_
15	deleted	delete	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
16	[	[	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
17	Jalaguier	Jalaguier	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
18	,	,	PUNCT	,	_	_	_	_	_
19	Mesnier	Mesnier	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
20	,	,	PUNCT	,	_	_	_	_	_
21	Leger	Leger	PROPN	NNP	Number=Sing	_	_	_	_
22	and	and	CCONJ	CC	_	_	_	_	_
23	Auzou	Auzou	PROPN	NNP	Number=Sing	_	_	_	_
24	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
25	1996	1996	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
26	)	)	PUNCT	-RRB-	_	_	_	_	_
27	J.Steroid	J.Steroid	PROPN	NNP	Number=Sing	_	_	_	_
28	Biochem.Mol.Biol	Biochem.Mol.Biol	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
29	.57	.57	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
30	,	,	PUNCT	,	_	_	_	_	_
31	43	43	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
32	-	-	SYM	SYM	_	_	_	_	SpaceAfter=No
33	50	50	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
34	]	]	PUNCT	-RRB-	_	_	_	_	_
35	supports	support	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
36	this	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
37	hypothesis	hypothesis	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
38	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 674
# text = Because of the similar behaviours of aldosterone and progesterone, we conclude that the N-terminal Thr729-Leu765 region of the HBD is similarly involved in the binding of both hormones.
1	Because	because	ADP	IN	_	_	_	_	_
2	of	of	ADP	IN	_	_	_	_	_
3	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
4	similar	similar	ADJ	JJ	Degree=Pos	_	_	_	_
5	behaviours	behaviour	NOUN	NNS	Number=Plur	_	_	_	_
6	of	of	ADP	IN	_	_	_	_	_
7	aldosterone	aldosterone	NOUN	NN	Number=Sing	_	_	_	_
8	and	and	CCONJ	CC	_	_	_	_	_
9	progesterone	progesterone	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
10	,	,	PUNCT	,	_	_	_	_	_
11	we	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
12	conclude	conclude	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
13	that	that	SCONJ	IN	_	_	_	_	_
14	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
15	N-	n-	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
16	terminal	terminal	NOUN	NN	Number=Sing	_	_	_	_
17	Thr729	Thr729	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
18	-	-	SYM	SYM	_	_	_	_	SpaceAfter=No
19	Leu765	Leu765	NUM	CD	NumType=Card	_	_	_	_
20	region	region	NOUN	NN	Number=Sing	_	_	_	_
21	of	of	ADP	IN	_	_	_	_	_
22	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
23	HBD	hbd	NOUN	NN	Number=Sing	_	_	_	_
24	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
25	similarly	similarly	ADV	RB	_	_	_	_	_
26	involved	involved	ADJ	JJ	Degree=Pos	_	_	_	_
27	in	in	ADP	IN	_	_	_	_	_
28	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
29	binding	binding	NOUN	NN	Number=Sing	_	_	_	_
30	of	of	ADP	IN	_	_	_	_	_
31	both	both	DET	DT	_	_	_	_	_
32	hormones	hormone	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
33	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 675
# text = Document 003002230 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	003002230	003002230	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 676
# text = High molecular weight dextran sulfate increases the activity of NF-kappaB-regulated promoter in monocyte-derived macrophages.
1	High	high	ADJ	JJ	Degree=Pos	_	_	_	_
2	molecular	molecular	ADJ	JJ	Degree=Pos	_	_	_	_
3	weight	weight	NOUN	NN	Number=Sing	_	_	_	_
4	dextran	dextrun	NOUN	NN	Number=Sing	_	_	_	_
5	sulfate	sulfate	NOUN	NN	Number=Sing	_	_	_	_
6	increases	increase	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
7	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
8	activity	activity	NOUN	NN	Number=Sing	_	_	_	_
9	of	of	ADP	IN	_	_	_	_	_
10	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
11	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
12	kappaB	kappaB	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
13	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
14	regulated	regulate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
15	promoter	promoter	NOUN	NN	Number=Sing	_	_	_	_
16	in	in	ADP	IN	_	_	_	_	_
17	monocyte	monocyte	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
18	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
19	derived	derive	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
20	macrophages	macrophage	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
21	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 677
# text = It is known that sulfated polysaccharides can mimic the action of common T-cell mitogens.
1	It	it	PRON	PRP	Case=Nom|Gender=Neut|Number=Sing|Person=3|PronType=Prs	_	_	_	_
2	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
3	known	know	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
4	that	that	SCONJ	IN	_	_	_	_	_
5	sulfated	sulfate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
6	polysaccharides	polysaccharide	NOUN	NNS	Number=Plur	_	_	_	_
7	can	can	AUX	MD	VerbForm=Fin	_	_	_	_
8	mimic	mimic	ADJ	JJ	Degree=Pos	_	_	_	_
9	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
10	action	action	NOUN	NN	Number=Sing	_	_	_	_
11	of	of	ADP	IN	_	_	_	_	_
12	common	common	ADJ	JJ	Degree=Pos	_	_	_	_
13	T-	t-	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
14	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
15	mitogens	mitogen	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
16	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 678
# text = To investigate the molecular basis of the mitogenic effect of high molecular weight dextran sulfate (HMDS), monocyte-derived macrophages were transfected with recombinant plasmid containing chloramphenicol acetyl transferase (CAT) reporter gene under the control of the HIV-1 long terminal repeat (LTR) promoter, which is regulated by transcription factor NF-kappaB.
1	To	to	PART	TO	_	_	_	_	_
2	investigate	investigate	VERB	VB	VerbForm=Inf	_	_	_	_
3	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
4	molecular	molecular	ADJ	JJ	Degree=Pos	_	_	_	_
5	basis	basis	NOUN	NN	Number=Sing	_	_	_	_
6	of	of	ADP	IN	_	_	_	_	_
7	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
8	mitogenic	mitogenic	ADJ	JJ	Degree=Pos	_	_	_	_
9	effect	effect	NOUN	NN	Number=Sing	_	_	_	_
10	of	of	ADP	IN	_	_	_	_	_
11	high	high	ADJ	JJ	Degree=Pos	_	_	_	_
12	molecular	molecular	ADJ	JJ	Degree=Pos	_	_	_	_
13	weight	weight	NOUN	NN	Number=Sing	_	_	_	_
14	dextran	dextran	NOUN	NN	Number=Sing	_	_	_	_
15	sulfate	sulfate	NOUN	NN	Number=Sing	_	_	_	_
16	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
17	HMDS	hmds	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
18	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
19	,	,	PUNCT	,	_	_	_	_	_
20	monocyte	monocyte	VERB	VB	VerbForm=Inf	_	_	_	SpaceAfter=No
21	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
22	derived	derive	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
23	macrophages	macrophage	NOUN	NNS	Number=Plur	_	_	_	_
24	were	be	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
25	transfected	transfect	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
26	with	with	ADP	IN	_	_	_	_	_
27	recombinant	recombinant	NOUN	NN	Number=Sing	_	_	_	_
28	plasmid	plasmid	NOUN	NN	Number=Sing	_	_	_	_
29	containing	contain	VERB	VBG	VerbForm=Ger	_	_	_	_
30	chloramphenicol	chloramphenicol	NOUN	NN	Number=Sing	_	_	_	_
31	acetyl	acetyl	NOUN	NN	Number=Sing	_	_	_	_
32	transferase	transferase	NOUN	NN	Number=Sing	_	_	_	_
33	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
34	CAT	cat	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
35	)	)	PUNCT	-RRB-	_	_	_	_	_
36	reporter	reporter	NOUN	NN	Number=Sing	_	_	_	_
37	gene	gene	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
38	under	under	ADP	IN	_	_	_	_	_
39	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
40	control	control	NOUN	NN	Number=Sing	_	_	_	_
41	of	of	ADP	IN	_	_	_	_	_
42	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
43	HIV	HIV	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
44	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
45	1	1	NUM	CD	NumType=Card	_	_	_	_
46	long	long	ADJ	JJ	Degree=Pos	_	_	_	_
47	terminal	terminal	NOUN	NN	Number=Sing	_	_	_	_
48	repeat	repeat	NOUN	NN	Number=Sing	_	_	_	_
49	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
50	LTR	LTR	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
51	)	)	PUNCT	-RRB-	_	_	_	_	_
52	promoter	promoter	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
53	,	,	PUNCT	,	_	_	_	_	_
54	which	which	PRON	WDT	PronType=Rel	_	_	_	_
55	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
56	regulated	regulate	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
57	by	by	ADP	IN	_	_	_	_	_
58	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
59	factor	factor	NOUN	NN	Number=Sing	_	_	_	_
60	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
61	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
62	kappaB	kappaB	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
63	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 679
# text = We observed that HMDS, similar to bacterial lipopolysaccharide (LPS), increases the expression of CAT reporter gene suggesting increased activity of NF-kappaB.
1	We	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
2	observed	observe	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
3	that	that	SCONJ	IN	_	_	_	_	_
4	HMDS	HMDS	PROPN	NNPS	Number=Plur	_	_	_	SpaceAfter=No
5	,	,	PUNCT	,	_	_	_	_	_
6	similar	similar	ADJ	JJ	Degree=Pos	_	_	_	_
7	to	to	ADP	IN	_	_	_	_	_
8	bacterial	bacterial	ADJ	JJ	Degree=Pos	_	_	_	_
9	lipopolysaccharide	lipopolysaccharide	NOUN	NN	Number=Sing	_	_	_	_
10	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
11	LPS	Lp	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
12	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
13	,	,	PUNCT	,	_	_	_	_	_
14	increases	increase	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
15	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
16	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
17	of	of	ADP	IN	_	_	_	_	_
18	CAT	Cat	ADJ	JJ	Degree=Pos	_	_	_	_
19	reporter	reporter	NOUN	NN	Number=Sing	_	_	_	_
20	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
21	suggesting	suggeste	VERB	VBG	VerbForm=Ger	_	_	_	_
22	increased	increase	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
23	activity	activity	NOUN	NN	Number=Sing	_	_	_	_
24	of	of	ADP	IN	_	_	_	_	_
25	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
26	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
27	kappaB	kappaB	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
28	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 680
# text = The activation of NF-kappaB correlated with the increased expression of B7.1 molecules.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
3	of	of	ADP	IN	_	_	_	_	_
4	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
5	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
6	kappaB	kappaB	PROPN	NNP	Number=Sing	_	_	_	_
7	correlated	correlate	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
8	with	with	ADP	IN	_	_	_	_	_
9	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
10	increased	increase	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
11	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
12	of	of	ADP	IN	_	_	_	_	_
13	B7.1	B7.1	NUM	CD	NumType=Card	_	_	_	_
14	molecules	molecule	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
15	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 681
# text = It was postulated that this NF-kappaB-regulated promoter might play a role in the activation of the accessory cells as well as the rate of replication of HIV-1 in monocyte-derived macrophages.
1	It	it	PRON	PRP	Case=Nom|Gender=Neut|Number=Sing|Person=3|PronType=Prs	_	_	_	_
2	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
3	postulated	postulate	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
4	that	that	SCONJ	IN	_	_	_	_	_
5	this	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
6	NF	Nf	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
7	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
8	kappaB-	kappaB-	PUNCT	:	_	_	_	_	SpaceAfter=No
9	regulated	regulate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
10	promoter	promoter	NOUN	NN	Number=Sing	_	_	_	_
11	might	might	AUX	MD	VerbForm=Fin	_	_	_	_
12	play	play	VERB	VB	VerbForm=Inf	_	_	_	_
13	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
14	role	role	NOUN	NN	Number=Sing	_	_	_	_
15	in	in	ADP	IN	_	_	_	_	_
16	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
17	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
18	of	of	ADP	IN	_	_	_	_	_
19	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
20	accessory	accessory	ADJ	JJ	Degree=Pos	_	_	_	_
21	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
22	as	as	ADV	RB	_	_	_	_	_
23	well	well	ADV	RB	Degree=Pos	_	_	_	_
24	as	as	ADP	IN	_	_	_	_	_
25	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
26	rate	rate	NOUN	NN	Number=Sing	_	_	_	_
27	of	of	ADP	IN	_	_	_	_	_
28	replication	replication	NOUN	NN	Number=Sing	_	_	_	_
29	of	of	ADP	IN	_	_	_	_	_
30	HIV	HIV	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
31	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
32	1	1	NUM	CD	NumType=Card	_	_	_	_
33	in	in	ADP	IN	_	_	_	_	_
34	monocyte	monocyte	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
35	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
36	derived	derive	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
37	macrophages	macrophage	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
38	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 682
# text = Document 003002237 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	003002237	003002237	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 683
# text = ETS1 transactivates the human GM-CSF promoter in Jurkat T cells stimulated with PMA and ionomycin.
1	ETS1	ETS1	PROPN	NNP	Number=Sing	_	_	_	_
2	transactivates	transactivate	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
3	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
4	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
5	GM	GM	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
6	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
7	CSF	CSF	PROPN	NNP	Number=Sing	_	_	_	_
8	promoter	promoter	NOUN	NN	Number=Sing	_	_	_	_
9	in	in	ADP	IN	_	_	_	_	_
10	Jurkat	Jurkat	PROPN	NNP	Number=Sing	_	_	_	_
11	T	t	PROPN	NNP	Number=Sing	_	_	_	_
12	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
13	stimulated	stimulate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
14	with	with	ADP	IN	_	_	_	_	_
15	PMA	Pma	PROPN	NNP	Number=Sing	_	_	_	_
16	and	and	CCONJ	CC	_	_	_	_	_
17	ionomycin	ionomycin	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
18	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 684
# text = Activation of T helper cells results in coordinate expression of a number of cytokines involved in differentiation, proliferation and activation of the haematopoietic system.
1	Activation	Activation	NOUN	NN	Number=Sing	_	_	_	_
2	of	of	ADP	IN	_	_	_	_	_
3	T	t	PROPN	NNP	Number=Sing	_	_	_	_
4	helper	helper	ADJ	JJR	Degree=Cmp	_	_	_	_
5	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
6	results	result	NOUN	NNS	Number=Plur	_	_	_	_
7	in	in	ADP	IN	_	_	_	_	_
8	coordinate	coordinate	ADJ	JJ	Degree=Pos	_	_	_	_
9	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
10	of	of	ADP	IN	_	_	_	_	_
11	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
12	number	number	NOUN	NN	Number=Sing	_	_	_	_
13	of	of	ADP	IN	_	_	_	_	_
14	cytokines	cytokine	NOUN	NNS	Number=Plur	_	_	_	_
15	involved	involve	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
16	in	in	ADP	IN	_	_	_	_	_
17	differentiation	differentiation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
18	,	,	PUNCT	,	_	_	_	_	_
19	proliferation	proliferation	NOUN	NN	Number=Sing	_	_	_	_
20	and	and	CCONJ	CC	_	_	_	_	_
21	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
22	of	of	ADP	IN	_	_	_	_	_
23	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
24	haematopoietic	haematopoietic	ADJ	JJ	Degree=Pos	_	_	_	_
25	system	system	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
26	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 685
# text = Granulocyte-macrophage colony-stimulating factor (GM-CSF) is one such cytokine whose increased expression results partly from increases in transcription.
1	Granulocyte	Granulocyte	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
2	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
3	macrophage	macrophage	NOUN	NN	Number=Sing	_	_	_	_
4	colony	colony	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
5	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
6	stimulating	stimulating	NOUN	NN	Number=Sing	_	_	_	_
7	factor	factor	NOUN	NN	Number=Sing	_	_	_	_
8	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
9	GM	GM	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
10	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
11	CSF	CSF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
12	)	)	PUNCT	-RRB-	_	_	_	_	_
13	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
14	one	one	NUM	CD	NumType=Card	_	_	_	_
15	such	such	ADJ	JJ	Degree=Pos	_	_	_	_
16	cytokine	cytokine	NOUN	NN	Number=Sing	_	_	_	_
17	whose	whose	PRON	WP$	Poss=Yes|PronType=Int	_	_	_	_
18	increased	increase	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
19	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
20	results	result	NOUN	NNS	Number=Plur	_	_	_	_
21	partly	partly	ADV	RB	_	_	_	_	_
22	from	from	ADP	IN	_	_	_	_	_
23	increases	increase	NOUN	NNS	Number=Plur	_	_	_	_
24	in	in	ADP	IN	_	_	_	_	_
25	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
26	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 686
# text = Cis-acting elements with NF kappa B, AP-1 and ETS-like motifs have been identified in the promoter region of the GM-CSF gene, which are important for transcriptional activity following PMA and ionomycin stimulation.
1	Cis	Cis	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
2	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
3	acting	act	VERB	VBG	VerbForm=Ger	_	_	_	_
4	elements	element	NOUN	NNS	Number=Plur	_	_	_	_
5	with	with	ADP	IN	_	_	_	_	_
6	NF	NF	PROPN	NNP	Number=Sing	_	_	_	_
7	kappa	kappa	PROPN	NNP	Number=Sing	_	_	_	_
8	B	B	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
9	,	,	PUNCT	,	_	_	_	_	_
10	AP	Ap	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
11	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
12	1	1	NUM	CD	NumType=Card	_	_	_	_
13	and	and	CCONJ	CC	_	_	_	_	_
14	ETS	Ets	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
15	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
16	like	like	SCONJ	IN	_	_	_	_	_
17	motifs	motif	NOUN	NNS	Number=Plur	_	_	_	_
18	have	have	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
19	been	be	AUX	VBN	Tense=Past|VerbForm=Part	_	_	_	_
20	identified	identify	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
21	in	in	ADP	IN	_	_	_	_	_
22	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
23	promoter	promoter	NOUN	NN	Number=Sing	_	_	_	_
24	region	region	NOUN	NN	Number=Sing	_	_	_	_
25	of	of	ADP	IN	_	_	_	_	_
26	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
27	GM	GM	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
28	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
29	CSF	CSF	PROPN	NNP	Number=Sing	_	_	_	_
30	gene	gene	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
31	,	,	PUNCT	,	_	_	_	_	_
32	which	which	PRON	WDT	PronType=Rel	_	_	_	_
33	are	be	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
34	important	important	ADJ	JJ	Degree=Pos	_	_	_	_
35	for	for	ADP	IN	_	_	_	_	_
36	transcriptional	transcriptional	ADJ	JJ	Degree=Pos	_	_	_	_
37	activity	activity	NOUN	NN	Number=Sing	_	_	_	_
38	following	follow	VERB	VBG	VerbForm=Ger	_	_	_	_
39	PMA	PMA	PROPN	NNP	Number=Sing	_	_	_	_
40	and	and	CCONJ	CC	_	_	_	_	_
41	ionomycin	ionomycin	ADP	IN	_	_	_	_	_
42	stimulation	stimulation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
43	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 687
# text = A number of the ETS family of transcription factors are expressed in T cells, including ETS1 and ELF1.
1	A	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
2	number	number	NOUN	NN	Number=Sing	_	_	_	_
3	of	of	ADP	IN	_	_	_	_	_
4	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
5	ETS	Ets	NOUN	NN	Number=Sing	_	_	_	_
6	family	family	NOUN	NN	Number=Sing	_	_	_	_
7	of	of	ADP	IN	_	_	_	_	_
8	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
9	factors	factor	NOUN	NNS	Number=Plur	_	_	_	_
10	are	be	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
11	expressed	express	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
12	in	in	ADP	IN	_	_	_	_	_
13	T	t	PROPN	NNP	Number=Sing	_	_	_	_
14	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
15	,	,	PUNCT	,	_	_	_	_	_
16	including	include	VERB	VBG	VerbForm=Ger	_	_	_	_
17	ETS1	ETS1	PROPN	NNP	Number=Sing	_	_	_	_
18	and	and	CCONJ	CC	_	_	_	_	_
19	ELF1	ELF1	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
20	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 688
# text = Here we describe the ability of these factors to interact with a site (GM5), located within the CLE0 element, -47 to -40 upstream of the GM-CSF transcription initiation site.
1	Here	here	ADV	RB	PronType=Dem	_	_	_	_
2	we	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
3	describe	describe	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
4	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
5	ability	ability	NOUN	NN	Number=Sing	_	_	_	_
6	of	of	ADP	IN	_	_	_	_	_
7	these	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
8	factors	factor	NOUN	NNS	Number=Plur	_	_	_	_
9	to	to	PART	TO	_	_	_	_	_
10	interact	interact	VERB	VB	VerbForm=Inf	_	_	_	_
11	with	with	ADP	IN	_	_	_	_	_
12	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
13	site	site	NOUN	NN	Number=Sing	_	_	_	_
14	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
15	GM5	GM5	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
16	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
17	,	,	PUNCT	,	_	_	_	_	_
18	located	locate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
19	within	within	ADP	IN	_	_	_	_	_
20	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
21	CLE0	CLE0	PROPN	NNP	Number=Sing	_	_	_	_
22	element	element	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
23	,	,	PUNCT	,	_	_	_	_	_
24	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
25	47	47	NUM	CD	NumType=Card	_	_	_	_
26	to	to	ADP	IN	_	_	_	_	_
27	-	-	SYM	SYM	_	_	_	_	SpaceAfter=No
28	40	40	NUM	CD	NumType=Card	_	_	_	_
29	upstream	upstream	NOUN	NN	Number=Sing	_	_	_	_
30	of	of	ADP	IN	_	_	_	_	_
31	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
32	GM	GM	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
33	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
34	CSF	CSF	PROPN	NNP	Number=Sing	_	_	_	_
35	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
36	initiation	initiation	NOUN	NN	Number=Sing	_	_	_	_
37	site	site	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
38	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 689
# text = Exogenous ETS1, but not ELF1, can transactivate GM-CSF, through the GM5 site, in a PMA/ionomycin dependent manner.
1	Exogenous	Exogenous	PROPN	NNP	Number=Sing	_	_	_	_
2	ETS1	Ets1	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
3	,	,	PUNCT	,	_	_	_	_	_
4	but	but	CCONJ	CC	_	_	_	_	_
5	not	not	ADV	RB	_	_	_	_	_
6	ELF1	ELF1	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
7	,	,	PUNCT	,	_	_	_	_	_
8	can	can	AUX	MD	VerbForm=Fin	_	_	_	_
9	transactivate	transactivate	VERB	VB	VerbForm=Inf	_	_	_	_
10	GM	GM	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
11	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
12	CSF	CSF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
13	,	,	PUNCT	,	_	_	_	_	_
14	through	through	ADP	IN	_	_	_	_	_
15	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
16	GM5	GM5	PROPN	NNP	Number=Sing	_	_	_	_
17	site	site	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
18	,	,	PUNCT	,	_	_	_	_	_
19	in	in	ADP	IN	_	_	_	_	_
20	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
21	PMA	PMA	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
22	/	/	PUNCT	,	_	_	_	_	SpaceAfter=No
23	ionomycin	ionomycin	ADP	IN	_	_	_	_	_
24	dependent	dependent	ADJ	JJ	Degree=Pos	_	_	_	_
25	manner	manner	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
26	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 690
# text = Other unidentified ETS-like factors present in Jurkat cells are also capable of binding GM5.
1	Other	other	ADJ	JJ	Degree=Pos	_	_	_	_
2	unidentified	unidentified	ADJ	JJ	Degree=Pos	_	_	_	_
3	ETS	Et	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
5	like	like	SCONJ	IN	_	_	_	_	_
6	factors	factor	NOUN	NNS	Number=Plur	_	_	_	_
7	present	present	VERB	VB	VerbForm=Inf	_	_	_	_
8	in	in	ADP	IN	_	_	_	_	_
9	Jurkat	Jurkat	PROPN	NNP	Number=Sing	_	_	_	_
10	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
11	are	be	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
12	also	also	ADV	RB	_	_	_	_	_
13	capable	capable	ADJ	JJ	Degree=Pos	_	_	_	_
14	of	of	SCONJ	IN	_	_	_	_	_
15	binding	bind	VERB	VBG	VerbForm=Ger	_	_	_	_
16	GM5	GM5	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
17	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 691
# text = Mutation of the core ETS binding site from -GGAA- to -GGAT- prevents the binding of ETS-like factors with the exception of ETS1.
1	Mutation	Mutation	NOUN	NN	Number=Sing	_	_	_	_
2	of	of	ADP	IN	_	_	_	_	_
3	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
4	core	core	NOUN	NN	Number=Sing	_	_	_	_
5	ETS	Et	NOUN	NN	Number=Sing	_	_	_	_
6	binding	bind	VERB	VBG	VerbForm=Ger	_	_	_	_
7	site	site	NOUN	NN	Number=Sing	_	_	_	_
8	from	from	ADP	IN	_	_	_	_	_
9	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
10	GGAA	GGAA	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
11	-	-	PUNCT	HYPH	_	_	_	_	_
12	to	to	ADP	IN	_	_	_	_	_
13	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
14	GGAT	Ggat	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
15	-	-	PUNCT	HYPH	_	_	_	_	_
16	prevents	prevent	NOUN	NNS	Number=Plur	_	_	_	_
17	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
18	binding	binding	NOUN	NN	Number=Sing	_	_	_	_
19	of	of	ADP	IN	_	_	_	_	_
20	ETS	Ets	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
21	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
22	like	like	SCONJ	IN	_	_	_	_	_
23	factors	factor	NOUN	NNS	Number=Plur	_	_	_	_
24	with	with	ADP	IN	_	_	_	_	_
25	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
26	exception	exception	NOUN	NN	Number=Sing	_	_	_	_
27	of	of	ADP	IN	_	_	_	_	_
28	ETS1	ETS1	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
29	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 692
# text = The GM-CSF promoter, modified in this way to be ETS1 specific, is fully responsive to PMA/ionomycin induction, in addition to ETS1 transactivation in the presence of PMA and ionomycin.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	GM	GM	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
3	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
4	CSF	CSF	PROPN	NNP	Number=Sing	_	_	_	_
5	promoter	promoter	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
6	,	,	PUNCT	,	_	_	_	_	_
7	modified	modify	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
8	in	in	ADP	IN	_	_	_	_	_
9	this	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
10	way	way	NOUN	NN	Number=Sing	_	_	_	_
11	to	to	PART	TO	_	_	_	_	_
12	be	be	AUX	VB	VerbForm=Inf	_	_	_	_
13	ETS1	ETS1	PROPN	NNP	Number=Sing	_	_	_	_
14	specific	specific	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
15	,	,	PUNCT	,	_	_	_	_	_
16	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
17	fully	fully	ADV	RB	_	_	_	_	_
18	responsive	responsive	ADJ	JJ	Degree=Pos	_	_	_	_
19	to	to	ADP	IN	_	_	_	_	_
20	PMA	PMA	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
21	/	/	PUNCT	,	_	_	_	_	SpaceAfter=No
22	ionomycin	ionomycin	ADJ	JJ	Degree=Pos	_	_	_	_
23	induction	induction	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
24	,	,	PUNCT	,	_	_	_	_	_
25	in	in	ADP	IN	_	_	_	_	_
26	addition	addition	NOUN	NN	Number=Sing	_	_	_	_
27	to	to	ADP	IN	_	_	_	_	_
28	ETS1	ETS1	NUM	CD	NumType=Card	_	_	_	_
29	transactivation	transactivation	NOUN	NN	Number=Sing	_	_	_	_
30	in	in	ADP	IN	_	_	_	_	_
31	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
32	presence	presence	NOUN	NN	Number=Sing	_	_	_	_
33	of	of	ADP	IN	_	_	_	_	_
34	PMA	PMA	PROPN	NNP	Number=Sing	_	_	_	_
35	and	and	CCONJ	CC	_	_	_	_	_
36	ionomycin	ionomycin	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
37	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 693
# text = Together these data suggest that ETS1 may be involved in mediating the increased GM-CSF production associated with T cell activation.
1	Together	together	SCONJ	IN	_	_	_	_	_
2	these	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
3	data	data	NOUN	NN	Number=Sing	_	_	_	_
4	suggest	suggest	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
5	that	that	SCONJ	IN	_	_	_	_	_
6	ETS1	Ets1	PROPN	NNP	Number=Sing	_	_	_	_
7	may	may	AUX	MD	VerbForm=Fin	_	_	_	_
8	be	be	AUX	VB	VerbForm=Inf	_	_	_	_
9	involved	involved	ADJ	JJ	Degree=Pos	_	_	_	_
10	in	in	SCONJ	IN	_	_	_	_	_
11	mediating	mediat	VERB	VBG	VerbForm=Ger	_	_	_	_
12	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
13	increased	increase	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
14	GM	GM	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
15	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
16	CSF	CSF	PROPN	NNP	Number=Sing	_	_	_	_
17	production	production	NOUN	NN	Number=Sing	_	_	_	_
18	associated	associate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
19	with	with	ADP	IN	_	_	_	_	_
20	T	t	PROPN	NNP	Number=Sing	_	_	_	_
21	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
22	activation	activation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
23	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 694
# text = Document 003002240 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	003002240	003002240	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 695
# text = Monoclonal anti-endothelial cell antibodies from a patient with Takayasu arteritis activate endothelial cells from large vessels.
1	Monoclonal	Monoclonal	ADJ	JJ	Degree=Pos	_	_	_	_
2	anti-endothelial	anti-endothelial	ADJ	JJ	Degree=Pos	_	_	_	_
3	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
4	antibodies	antibody	NOUN	NNS	Number=Plur	_	_	_	_
5	from	from	ADP	IN	_	_	_	_	_
6	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
7	patient	patient	NOUN	NN	Number=Sing	_	_	_	_
8	with	with	ADP	IN	_	_	_	_	_
9	Takayasu	Takayasu	PROPN	NNP	Number=Sing	_	_	_	_
10	arteritis	arteritis	PROPN	NNPS	Number=Plur	_	_	_	_
11	activate	activate	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
12	endothelial	endothelial	ADJ	JJ	Degree=Pos	_	_	_	_
13	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
14	from	from	ADP	IN	_	_	_	_	_
15	large	large	ADJ	JJ	Degree=Pos	_	_	_	_
16	vessels	vessel	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
17	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 696
# text = OBJECTIVE:
1	OBJECTIVE	objective	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
2	:	:	PUNCT	:	_	_	_	_	_

# sent_id = 697
# text = To create monoclonal anti-endothelial cell antibodies (mAECA) from a patient with Takayasu arteritis to evaluate their ability to activate human umbilical vein endothelial cells (HUVEC), and to characterize the mechanism of EC activation.
1	To	to	PART	TO	_	_	_	_	_
2	create	create	VERB	VB	VerbForm=Inf	_	_	_	_
3	monoclonal	monoclonal	ADJ	JJ	Degree=Pos	_	_	_	_
4	anti-endothelial	anti-endothelial	ADJ	JJ	Degree=Pos	_	_	_	_
5	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
6	antibodies	antibody	NOUN	NNS	Number=Plur	_	_	_	_
7	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
8	mAECA	mAECa	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
9	)	)	PUNCT	-RRB-	_	_	_	_	_
10	from	from	ADP	IN	_	_	_	_	_
11	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
12	patient	patient	NOUN	NN	Number=Sing	_	_	_	_
13	with	with	ADP	IN	_	_	_	_	_
14	Takayasu	Takayasu	PROPN	NNP	Number=Sing	_	_	_	_
15	arteritis	arteritis	NOUN	NN	Number=Sing	_	_	_	_
16	to	to	PART	TO	_	_	_	_	_
17	evaluate	evaluate	VERB	VB	VerbForm=Inf	_	_	_	_
18	their	they	PRON	PRP$	Number=Plur|Person=3|Poss=Yes|PronType=Prs	_	_	_	_
19	ability	ability	NOUN	NN	Number=Sing	_	_	_	_
20	to	to	PART	TO	_	_	_	_	_
21	activate	activate	VERB	VB	VerbForm=Inf	_	_	_	_
22	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
23	umbilical	umbilical	ADJ	JJ	Degree=Pos	_	_	_	_
24	vein	vein	NOUN	NN	Number=Sing	_	_	_	_
25	endothelial	endothelial	ADJ	JJ	Degree=Pos	_	_	_	_
26	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
27	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
28	HUVEC	HUVEC	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
29	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
30	,	,	PUNCT	,	_	_	_	_	_
31	and	and	CCONJ	CC	_	_	_	_	_
32	to	to	PART	TO	_	_	_	_	_
33	characterize	characterize	VERB	VB	VerbForm=Inf	_	_	_	_
34	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
35	mechanism	mechanism	NOUN	NN	Number=Sing	_	_	_	_
36	of	of	ADP	IN	_	_	_	_	_
37	EC	EC	PROPN	NNP	Number=Sing	_	_	_	_
38	activation	activation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
39	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 698
# text = METHODS: A panel of mAECA was generated from peripheral blood lymphocytes of a patient with Takayasu arteritis, using Epstein-Barr virus transformation.
1	METHODS	methods	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
2	:	:	PUNCT	:	_	_	_	_	_
3	A	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
4	panel	panel	NOUN	NN	Number=Sing	_	_	_	_
5	of	of	ADP	IN	_	_	_	_	_
6	mAECA	mAECA	PROPN	NNP	Number=Sing	_	_	_	_
7	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
8	generated	generate	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
9	from	from	ADP	IN	_	_	_	_	_
10	peripheral	peripheral	ADJ	JJ	Degree=Pos	_	_	_	_
11	blood	blood	NOUN	NN	Number=Sing	_	_	_	_
12	lymphocytes	lymphocyte	NOUN	NNS	Number=Plur	_	_	_	_
13	of	of	ADP	IN	_	_	_	_	_
14	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
15	patient	patient	NOUN	NN	Number=Sing	_	_	_	_
16	with	with	ADP	IN	_	_	_	_	_
17	Takayasu	Takayasu	PROPN	NNP	Number=Sing	_	_	_	_
18	arteritis	arteritis	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
19	,	,	PUNCT	,	_	_	_	_	_
20	using	use	VERB	VBG	VerbForm=Ger	_	_	_	_
21	Epstein	Epstein	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
22	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
23	Barr	Barr	PROPN	NNP	Number=Sing	_	_	_	_
24	virus	virus	NOUN	NN	Number=Sing	_	_	_	_
25	transformation	transformation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
26	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 699
# text = Activity against macrovascular EC (HUVEC) and microvascular EC (human bone marrow EC immortalized by SV40) antigens was detected by enzyme-linked immunosorbent assay.
1	Activity	activity	NOUN	NN	Number=Sing	_	_	_	_
2	against	against	ADP	IN	_	_	_	_	_
3	macrovascular	macrovascular	ADJ	JJ	Degree=Pos	_	_	_	_
4	EC	EC	PROPN	NNP	Number=Sing	_	_	_	_
5	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
6	HUVEC	HUVEC	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
7	)	)	PUNCT	-RRB-	_	_	_	_	_
8	and	and	CCONJ	CC	_	_	_	_	_
9	microvascular	microvascular	ADJ	JJ	Degree=Pos	_	_	_	_
10	EC	EC	PROPN	NNP	Number=Sing	_	_	_	_
11	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
12	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
13	bone	bone	NOUN	NN	Number=Sing	_	_	_	_
14	marrow	marrow	NOUN	NN	Number=Sing	_	_	_	_
15	EC	EC	PROPN	NNP	Number=Sing	_	_	_	_
16	immortalized	immortalize	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
17	by	by	ADP	IN	_	_	_	_	_
18	SV40	SV40	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
19	)	)	PUNCT	-RRB-	_	_	_	_	_
20	antigens	antigen	NOUN	NNS	Number=Plur	_	_	_	_
21	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
22	detected	detect	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
23	by	by	ADP	IN	_	_	_	_	_
24	enzyme	enzyme	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
25	-linked	-link	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
26	immunosorbent	immunosorbent	ADJ	JJ	Degree=Pos	_	_	_	_
27	assay	assay	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
28	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 700
# text = Inhibition studies were used to select the monoclonal antibodies (mAECA) which share the same EC epitope binding specificity as the total IgG-AECA from the Takayasu arteritis patient.
1	Inhibition	Inhibition	NOUN	NN	Number=Sing	_	_	_	_
2	studies	study	NOUN	NNS	Number=Plur	_	_	_	_
3	were	be	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
4	used	use	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
5	to	to	PART	TO	_	_	_	_	_
6	select	select	VERB	VB	VerbForm=Inf	_	_	_	_
7	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
8	monoclonal	monoclonal	ADJ	JJ	Degree=Pos	_	_	_	_
9	antibodies	antibody	NOUN	NNS	Number=Plur	_	_	_	_
10	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
11	mAECA	mAECA	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
12	)	)	PUNCT	-RRB-	_	_	_	_	_
13	which	which	PRON	WDT	PronType=Rel	_	_	_	_
14	share	share	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
15	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
16	same	same	ADJ	JJ	Degree=Pos	_	_	_	_
17	EC	Ec	NOUN	NN	Number=Sing	_	_	_	_
18	epitope	epitope	NOUN	NN	Number=Sing	_	_	_	_
19	binding	bind	VERB	VBG	VerbForm=Ger	_	_	_	_
20	specificity	specificity	NOUN	NN	Number=Sing	_	_	_	_
21	as	as	ADP	IN	_	_	_	_	_
22	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
23	total	total	ADJ	JJ	Degree=Pos	_	_	_	_
24	IgG	IgG	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
25	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
26	AECA	AECA	PROPN	NNP	Number=Sing	_	_	_	_
27	from	from	ADP	IN	_	_	_	_	_
28	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
29	Takayasu	Takayasu	PROPN	NNP	Number=Sing	_	_	_	_
30	arteritis	arteritis	NOUN	NN	Number=Sing	_	_	_	_
31	patient	patient	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
32	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 701
# text = The binding of the mAECA to human aortic EC was studied by immunohistochemistry.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	binding	binding	NOUN	NN	Number=Sing	_	_	_	_
3	of	of	ADP	IN	_	_	_	_	_
4	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
5	mAECA	mAECa	PROPN	NNP	Number=Sing	_	_	_	_
6	to	to	PART	TO	_	_	_	_	_
7	human	human	VERB	VB	VerbForm=Inf	_	_	_	_
8	aortic	aortic	ADJ	JJ	Degree=Pos	_	_	_	_
9	EC	Ec	PROPN	NNP	Number=Sing	_	_	_	_
10	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
11	studied	study	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
12	by	by	ADP	IN	_	_	_	_	_
13	immunohistochemistry	immunohistochemistry	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
14	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 702
# text = The secretion levels of interleukin-6 (IL-6) and von Willebrand factor (vWF) were determined, to serve as markers for EC activation.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	secretion	secretion	NOUN	NN	Number=Sing	_	_	_	_
3	levels	level	NOUN	NNS	Number=Plur	_	_	_	_
4	of	of	ADP	IN	_	_	_	_	_
5	interleukin	interleukin	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
6	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
7	6	6	NUM	CD	NumType=Card	_	_	_	_
8	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
9	IL	Il	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
10	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
11	6	6	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
12	)	)	PUNCT	-RRB-	_	_	_	_	_
13	and	and	CCONJ	CC	_	_	_	_	_
14	von	von	PROPN	NNP	Number=Sing	_	_	_	_
15	Willebrand	Willebrand	PROPN	NNP	Number=Sing	_	_	_	_
16	factor	factor	NOUN	NN	Number=Sing	_	_	_	_
17	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
18	vWF	vWF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
19	)	)	PUNCT	-RRB-	_	_	_	_	_
20	were	be	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
21	determined	determined	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
22	,	,	PUNCT	,	_	_	_	_	_
23	to	to	PART	TO	_	_	_	_	_
24	serve	serve	VERB	VB	VerbForm=Inf	_	_	_	_
25	as	as	ADP	IN	_	_	_	_	_
26	markers	marker	NOUN	NNS	Number=Plur	_	_	_	_
27	for	for	ADP	IN	_	_	_	_	_
28	EC	EC	PROPN	NNP	Number=Sing	_	_	_	_
29	activation	activation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
30	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 703
# text = The activated EC were examined for the adherence of a monocytic cell line (U937), as well as for expression of vascular cell adhesion molecule 1, intercellular adhesion molecule 1, and E-selectin.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	activated	activated	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
3	EC	Ec	PROPN	NNP	Number=Sing	_	_	_	_
4	were	be	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
5	examined	examin	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
6	for	for	ADP	IN	_	_	_	_	_
7	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
8	adherence	adherence	NOUN	NN	Number=Sing	_	_	_	_
9	of	of	ADP	IN	_	_	_	_	_
10	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
11	monocytic	monocytic	ADJ	JJ	Degree=Pos	_	_	_	_
12	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
13	line	line	NOUN	NN	Number=Sing	_	_	_	_
14	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
15	U937	U937	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
16	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
17	,	,	PUNCT	,	_	_	_	_	_
18	as	as	ADV	RB	_	_	_	_	_
19	well	well	ADV	RB	Degree=Pos	_	_	_	_
20	as	as	ADP	IN	_	_	_	_	_
21	for	for	ADP	IN	_	_	_	_	_
22	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
23	of	of	ADP	IN	_	_	_	_	_
24	vascular	vascular	ADJ	JJ	Degree=Pos	_	_	_	_
25	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
26	adhesion	adhesion	NOUN	NN	Number=Sing	_	_	_	_
27	molecule	molecule	NOUN	NN	Number=Sing	_	_	_	_
28	1	1	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
29	,	,	PUNCT	,	_	_	_	_	_
30	intercellular	intercellular	ADJ	JJ	Degree=Pos	_	_	_	_
31	adhesion	adhesion	NOUN	NN	Number=Sing	_	_	_	_
32	molecule	molecule	NOUN	NN	Number=Sing	_	_	_	_
33	1	1	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
34	,	,	PUNCT	,	_	_	_	_	_
35	and	and	CCONJ	CC	_	_	_	_	_
36	E-	E-	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
37	selectin	selectin	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
38	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 704
# text = In addition, nuclear extracts of the mAECA-treated EC were analyzed for the induction of translocation of nuclear factor kappaB (NF-kappaB), using a specific NF-kappaB oligoprobe in an electrophoretic mobility shift assay.
1	In	in	ADP	IN	_	_	_	_	_
2	addition	addition	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
3	,	,	PUNCT	,	_	_	_	_	_
4	nuclear	nuclear	ADJ	JJ	Degree=Pos	_	_	_	_
5	extracts	extract	NOUN	NNS	Number=Plur	_	_	_	_
6	of	of	ADP	IN	_	_	_	_	_
7	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
8	mAECA	mAECA	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
9	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
10	treated	treat	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
11	EC	Ec	PROPN	NNP	Number=Sing	_	_	_	_
12	were	be	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
13	analyzed	analyze	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
14	for	for	ADP	IN	_	_	_	_	_
15	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
16	induction	induction	NOUN	NN	Number=Sing	_	_	_	_
17	of	of	ADP	IN	_	_	_	_	_
18	translocation	translocation	NOUN	NN	Number=Sing	_	_	_	_
19	of	of	ADP	IN	_	_	_	_	_
20	nuclear	nuclear	ADJ	JJ	Degree=Pos	_	_	_	_
21	factor	factor	NOUN	NN	Number=Sing	_	_	_	_
22	kappaB	kappaB	PROPN	NNP	Number=Sing	_	_	_	_
23	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
24	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
25	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
26	kappaB	kappaB	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
27	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
28	,	,	PUNCT	,	_	_	_	_	_
29	using	use	VERB	VBG	VerbForm=Ger	_	_	_	_
30	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
31	specific	specific	ADJ	JJ	Degree=Pos	_	_	_	_
32	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
33	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
34	kappaB	kappaB	PROPN	NNP	Number=Sing	_	_	_	_
35	oligoprobe	oligoprobe	AUX	VB	Mood=Imp|VerbForm=Fin	_	_	_	_
36	in	in	ADP	IN	_	_	_	_	_
37	an	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
38	electrophoretic	electrophoretic	ADJ	JJ	Degree=Pos	_	_	_	_
39	mobility	mobility	NOUN	NN	Number=Sing	_	_	_	_
40	shift	shift	NOUN	NN	Number=Sing	_	_	_	_
41	assay	assay	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
42	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 705
# text = RESULTS: Six mAECA were selected, the mixture of which produced 100% inhibition of binding of the original IgG (from the patient with Takayasu arteritis) to HUVEC.
1	RESULTS	results	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
2	:	:	PUNCT	:	_	_	_	_	_
3	Six	six	NUM	CD	NumType=Card	_	_	_	_
4	mAECA	maecan	NOUN	NN	Number=Sing	_	_	_	_
5	were	be	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
6	selected	select	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	SpaceAfter=No
7	,	,	PUNCT	,	_	_	_	_	_
8	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
9	mixture	mixture	NOUN	NN	Number=Sing	_	_	_	_
10	of	of	ADP	IN	_	_	_	_	_
11	which	which	PRON	WDT	PronType=Rel	_	_	_	_
12	produced	produce	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
13	100	100	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
14	%	%	SYM	NN	Number=Sing	_	_	_	_
15	inhibition	inhibition	NOUN	NN	Number=Sing	_	_	_	_
16	of	of	SCONJ	IN	_	_	_	_	_
17	binding	bind	VERB	VBG	VerbForm=Ger	_	_	_	_
18	of	of	ADP	IN	_	_	_	_	_
19	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
20	original	original	ADJ	JJ	Degree=Pos	_	_	_	_
21	IgG	IgG	PROPN	NNP	Number=Sing	_	_	_	_
22	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
23	from	from	ADP	IN	_	_	_	_	_
24	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
25	patient	patient	NOUN	NN	Number=Sing	_	_	_	_
26	with	with	ADP	IN	_	_	_	_	_
27	Takayasu	Takayasu	PROPN	NNP	Number=Sing	_	_	_	_
28	arteritis	arteritis	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
29	)	)	PUNCT	-RRB-	_	_	_	_	_
30	to	to	ADP	IN	_	_	_	_	_
31	HUVEC	HUVEC	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
32	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 706
# text = All mAECA possessed high activity against macrovascular EC, but none had significant antimicrovascular EC activity.
1	All	all	DET	DT	_	_	_	_	_
2	mAECA	mAECa	NOUN	NN	Number=Sing	_	_	_	_
3	possessed	possess	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
4	high	high	ADJ	JJ	Degree=Pos	_	_	_	_
5	activity	activity	NOUN	NN	Number=Sing	_	_	_	_
6	against	against	ADP	IN	_	_	_	_	_
7	macrovascular	macrovascular	ADJ	JJ	Degree=Pos	_	_	_	_
8	EC	EC	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
9	,	,	PUNCT	,	_	_	_	_	_
10	but	but	CCONJ	CC	_	_	_	_	_
11	none	none	NOUN	NN	Number=Sing	_	_	_	_
12	had	have	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
13	significant	significant	ADJ	JJ	Degree=Pos	_	_	_	_
14	antimicrovascular	antimicrovascular	ADJ	JJ	Degree=Pos	_	_	_	_
15	EC	EC	PROPN	NNP	Number=Sing	_	_	_	_
16	activity	activity	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
17	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 707
# text = The mAECA, but not normal human IgG, had anti-human aortic EC activity.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	mAECA	mAECa	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
3	,	,	PUNCT	,	_	_	_	_	_
4	but	but	CCONJ	CC	_	_	_	_	_
5	not	not	ADV	RB	_	_	_	_	_
6	normal	normal	ADJ	JJ	Degree=Pos	_	_	_	_
7	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
8	IgG	Igg	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
9	,	,	PUNCT	,	_	_	_	_	_
10	had	have	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
11	anti-human	anti-human	ADJ	JJ	Degree=Pos	_	_	_	_
12	aortic	aortic	ADJ	JJ	Degree=Pos	_	_	_	_
13	EC	EC	PROPN	NNP	Number=Sing	_	_	_	_
14	activity	activity	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
15	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 708
# text = Four of the 6 mAECA activated EC, manifested by increased IL-6 and vWF secretion.
1	Four	four	NOUN	NN	Number=Sing	_	_	_	_
2	of	of	ADP	IN	_	_	_	_	_
3	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
4	6	6	NUM	CD	NumType=Card	_	_	_	_
5	mAECA	mAECA	PROPN	NNP	Number=Sing	_	_	_	_
6	activated	activate	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
7	EC	EC	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
8	,	,	PUNCT	,	_	_	_	_	_
9	manifested	manifest	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
10	by	by	ADP	IN	_	_	_	_	_
11	increased	increase	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
12	IL	Il	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
13	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
14	6	6	NUM	CD	NumType=Card	_	_	_	_
15	and	and	CCONJ	CC	_	_	_	_	_
16	vWF	vwf	NOUN	NN	Number=Sing	_	_	_	_
17	secretion	secretion	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
18	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 709
# text = The 4 mAECA induced EC expression of adhesion molecules and increased adhesion of U937 monocytic cells to EC.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	4	4	NUM	CD	NumType=Card	_	_	_	_
3	mAECA	mAECa	NOUN	NN	Number=Sing	_	_	_	_
4	induced	induce	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
5	EC	EC	PROPN	NNP	Number=Sing	_	_	_	_
6	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
7	of	of	ADP	IN	_	_	_	_	_
8	adhesion	adhesion	NOUN	NN	Number=Sing	_	_	_	_
9	molecules	molecule	NOUN	NNS	Number=Plur	_	_	_	_
10	and	and	CCONJ	CC	_	_	_	_	_
11	increased	increase	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
12	adhesion	adhesion	NOUN	NN	Number=Sing	_	_	_	_
13	of	of	ADP	IN	_	_	_	_	_
14	U937	U937	NUM	CD	NumType=Card	_	_	_	_
15	monocytic	monocytic	ADJ	JJ	Degree=Pos	_	_	_	_
16	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
17	to	to	ADP	IN	_	_	_	_	_
18	EC	EC	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
19	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 710
# text = In addition, these mAECA stimulated the nuclear translocation of the NF-kappaB transcription factor.
1	In	in	ADP	IN	_	_	_	_	_
2	addition	addition	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
3	,	,	PUNCT	,	_	_	_	_	_
4	these	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
5	mAECA	mAECA	PROPN	NNP	Number=Sing	_	_	_	_
6	stimulated	stimulate	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
7	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
8	nuclear	nuclear	ADJ	JJ	Degree=Pos	_	_	_	_
9	translocation	translocation	NOUN	NN	Number=Sing	_	_	_	_
10	of	of	ADP	IN	_	_	_	_	_
11	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
12	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
13	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
14	kappaB	kappaB	PROPN	NNP	Number=Sing	_	_	_	_
15	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
16	factor	factor	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
17	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 711
# text = CONCLUSION:
1	CONCLUSION	conclusion	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
2	:	:	PUNCT	:	_	_	_	_	_

# sent_id = 712
# text = Our findings suggest that AECA may directly stimulate EC in Takayasu arteritis through elevation of adhesion molecule expression associated with NF-kappaB activation and adhesion of monocytes, and may therefore play a pathogenic role in the development of the vasculopathy in Takayasu arteritis.
1	Our	we	PRON	PRP$	Number=Plur|Person=1|Poss=Yes|PronType=Prs	_	_	_	_
2	findings	finding	NOUN	NNS	Number=Plur	_	_	_	_
3	suggest	suggest	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
4	that	that	SCONJ	IN	_	_	_	_	_
5	AECA	AECA	PROPN	NNP	Number=Sing	_	_	_	_
6	may	may	AUX	MD	VerbForm=Fin	_	_	_	_
7	directly	directly	ADV	RB	_	_	_	_	_
8	stimulate	stimulate	VERB	VB	VerbForm=Inf	_	_	_	_
9	EC	EC	PROPN	NNP	Number=Sing	_	_	_	_
10	in	in	ADP	IN	_	_	_	_	_
11	Takayasu	Takayasu	PROPN	NNP	Number=Sing	_	_	_	_
12	arteritis	arteritis	ADV	RB	_	_	_	_	_
13	through	through	ADP	IN	_	_	_	_	_
14	elevation	elevation	NOUN	NN	Number=Sing	_	_	_	_
15	of	of	ADP	IN	_	_	_	_	_
16	adhesion	adhesion	NOUN	NN	Number=Sing	_	_	_	_
17	molecule	molecule	NOUN	NN	Number=Sing	_	_	_	_
18	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
19	associated	associate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
20	with	with	ADP	IN	_	_	_	_	_
21	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
22	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
23	kappaB	kappaB	PROPN	NNP	Number=Sing	_	_	_	_
24	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
25	and	and	CCONJ	CC	_	_	_	_	_
26	adhesion	adhesion	NOUN	NN	Number=Sing	_	_	_	_
27	of	of	ADP	IN	_	_	_	_	_
28	monocytes	monocyte	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
29	,	,	PUNCT	,	_	_	_	_	_
30	and	and	CCONJ	CC	_	_	_	_	_
31	may	may	AUX	MD	VerbForm=Fin	_	_	_	_
32	therefore	therefore	ADV	RB	_	_	_	_	_
33	play	play	VERB	VB	VerbForm=Inf	_	_	_	_
34	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
35	pathogenic	pathogenic	ADJ	JJ	Degree=Pos	_	_	_	_
36	role	role	NOUN	NN	Number=Sing	_	_	_	_
37	in	in	ADP	IN	_	_	_	_	_
38	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
39	development	development	NOUN	NN	Number=Sing	_	_	_	_
40	of	of	ADP	IN	_	_	_	_	_
41	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
42	vasculopathy	vasculopathy	NOUN	NN	Number=Sing	_	_	_	_
43	in	in	ADP	IN	_	_	_	_	_
44	Takayasu	Takayasu	PROPN	NNP	Number=Sing	_	_	_	_
45	arteritis	arteritis	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
46	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 713
# text = Document 003002246 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	003002246	003002246	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 714
# text = Coexpression of NF-kappa B/Rel and Sp1 transcription factors in human immunodeficiency virus 1-induced, dendritic cell-T-cell syncytia.
1	Coexpression	Coexpression	NOUN	NN	Number=Sing	_	_	_	_
2	of	of	ADP	IN	_	_	_	_	_
3	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
4	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
5	kappa	kappa	PROPN	NNP	Number=Sing	_	_	_	_
6	B	B	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
7	/	/	PUNCT	,	_	_	_	_	SpaceAfter=No
8	Rel	Rel	PROPN	NNP	Number=Sing	_	_	_	_
9	and	and	CCONJ	CC	_	_	_	_	_
10	Sp1	Sp1	NUM	CD	NumType=Card	_	_	_	_
11	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
12	factors	factor	NOUN	NNS	Number=Plur	_	_	_	_
13	in	in	ADP	IN	_	_	_	_	_
14	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
15	immunodeficiency	immunodeficiency	NOUN	NN	Number=Sing	_	_	_	_
16	virus	virus	NOUN	NN	Number=Sing	_	_	_	_
17	1	1	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
18	-	-	PUNCT	:	_	_	_	_	SpaceAfter=No
19	induced	induce	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	SpaceAfter=No
20	,	,	PUNCT	,	_	_	_	_	_
21	dendritic	dendritic	ADJ	JJ	Degree=Pos	_	_	_	_
22	cell	cell	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
23	-T	-t	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
24	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
25	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
26	syncytia	syncytia	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
27	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 715
# text = Productive infection of T cells with human immunodeficiency virus 1 (HIV-1) typically requires that the T cells be stimulated with antigens or mitogens.
1	Productive	Productive	ADJ	JJ	Degree=Pos	_	_	_	_
2	infection	infection	NOUN	NN	Number=Sing	_	_	_	_
3	of	of	ADP	IN	_	_	_	_	_
4	T	t	PROPN	NNP	Number=Sing	_	_	_	_
5	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
6	with	with	ADP	IN	_	_	_	_	_
7	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
8	immunodeficiency	immunodeficiency	NOUN	NN	Number=Sing	_	_	_	_
9	virus	virus	NOUN	NN	Number=Sing	_	_	_	_
10	1	1	NUM	CD	NumType=Card	_	_	_	_
11	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
12	HIV	Hiv	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
13	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
14	1	1	X	LS	_	_	_	_	SpaceAfter=No
15	)	)	PUNCT	-RRB-	_	_	_	_	_
16	typically	typically	ADV	RB	_	_	_	_	_
17	requires	require	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
18	that	that	SCONJ	IN	_	_	_	_	_
19	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
20	T	t	PROPN	NNP	Number=Sing	_	_	_	_
21	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
22	be	be	AUX	VB	VerbForm=Inf	_	_	_	_
23	stimulated	stimulate	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
24	with	with	ADP	IN	_	_	_	_	_
25	antigens	antigen	NOUN	NNS	Number=Plur	_	_	_	_
26	or	or	CCONJ	CC	_	_	_	_	_
27	mitogens	mitogen	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
28	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 716
# text = This requirement has been attributed to the activation of the transcription factor NF-kappa B, which synergizes with the constitutive transcription factor Sp1 to drive the HIV-1 promoter.
1	This	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
2	requirement	requirement	NOUN	NN	Number=Sing	_	_	_	_
3	has	have	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
4	been	be	AUX	VBN	Tense=Past|VerbForm=Part	_	_	_	_
5	attributed	attribute	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
6	to	to	ADP	IN	_	_	_	_	_
7	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
8	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
9	of	of	ADP	IN	_	_	_	_	_
10	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
11	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
12	factor	factor	NOUN	NN	Number=Sing	_	_	_	_
13	NF	Nf	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
14	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
15	kappa	kappa	PROPN	NNP	Number=Sing	_	_	_	_
16	B	b	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
17	,	,	PUNCT	,	_	_	_	_	_
18	which	which	PRON	WDT	PronType=Rel	_	_	_	_
19	synergizes	synergize	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
20	with	with	ADP	IN	_	_	_	_	_
21	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
22	constitutive	constitutive	ADJ	JJ	Degree=Pos	_	_	_	_
23	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
24	factor	factor	NOUN	NN	Number=Sing	_	_	_	_
25	Sp1	sp1	NOUN	NN	Number=Sing	_	_	_	_
26	to	to	PART	TO	_	_	_	_	_
27	drive	drive	VERB	VB	VerbForm=Inf	_	_	_	_
28	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
29	HIV	Hiv	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
30	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
31	1	1	NUM	CD	NumType=Card	_	_	_	_
32	promoter	promoter	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
33	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 717
# text = Recently, we have found that vigorous replication of HIV-1 takes place in nonactivated memory T cells after syncytium formation with dendritic cells (DCs).
1	Recently	recently	ADV	RB	_	_	_	_	SpaceAfter=No
2	,	,	PUNCT	,	_	_	_	_	_
3	we	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
4	have	have	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
5	found	find	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
6	that	that	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
7	vigorous	vigorous	ADJ	JJ	Degree=Pos	_	_	_	_
8	replication	replication	NOUN	NN	Number=Sing	_	_	_	_
9	of	of	ADP	IN	_	_	_	_	_
10	HIV	HIV	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
11	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
12	1	1	NUM	CD	NumType=Card	_	_	_	_
13	takes	take	NOUN	NNS	Number=Plur	_	_	_	_
14	place	place	NOUN	NN	Number=Sing	_	_	_	_
15	in	in	ADP	IN	_	_	_	_	_
16	nonactivated	nonactivated	ADJ	JJ	Degree=Pos	_	_	_	_
17	memory	memory	NOUN	NN	Number=Sing	_	_	_	_
18	T	t	PROPN	NNP	Number=Sing	_	_	_	_
19	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
20	after	after	ADP	IN	_	_	_	_	_
21	syncytium	syncytium	NOUN	NN	Number=Sing	_	_	_	_
22	formation	formation	NOUN	NN	Number=Sing	_	_	_	_
23	with	with	ADP	IN	_	_	_	_	_
24	dendritic	dendritic	ADJ	JJ	Degree=Pos	_	_	_	_
25	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
26	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
27	DCs	DC	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
28	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
29	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 718
# text = These syncytia lack activated cells as determined by an absence of staining for Ki-67 cell cycle antigen.
1	These	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
2	syncytia	syncytia	NOUN	NN	Number=Sing	_	_	_	_
3	lack	lack	NOUN	NN	Number=Sing	_	_	_	_
4	activated	activate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
5	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
6	as	as	SCONJ	IN	_	_	_	_	_
7	determined	determine	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
8	by	by	ADP	IN	_	_	_	_	_
9	an	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
10	absence	absence	NOUN	NN	Number=Sing	_	_	_	_
11	of	of	SCONJ	IN	_	_	_	_	_
12	staining	stain	VERB	VBG	VerbForm=Ger	_	_	_	_
13	for	for	ADP	IN	_	_	_	_	_
14	Ki	Ki	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
15	-67	-67	NUM	CD	NumType=Card	_	_	_	_
16	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
17	cycle	cycle	NOUN	NN	Number=Sing	_	_	_	_
18	antigen	antigen	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
19	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 719
# text = The expression and activity of NF-kappa B and Sp1 were, therefore, analyzed in isolated T cells and DCs from humans and mice.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
3	and	and	CCONJ	CC	_	_	_	_	_
4	activity	activity	NOUN	NN	Number=Sing	_	_	_	_
5	of	of	ADP	IN	_	_	_	_	_
6	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
7	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
8	kappa	kappa	PROPN	NNP	Number=Sing	_	_	_	_
9	B	B	PROPN	NNP	Number=Sing	_	_	_	_
10	and	and	CCONJ	CC	_	_	_	_	_
11	Sp1	Sp1	PROPN	NNP	Number=Sing	_	_	_	_
12	were	be	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	SpaceAfter=No
13	,	,	PUNCT	,	_	_	_	_	_
14	therefore	therefore	ADV	RB	_	_	_	_	SpaceAfter=No
15	,	,	PUNCT	,	_	_	_	_	_
16	analyzed	analyze	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
17	in	in	ADP	IN	_	_	_	_	_
18	isolated	isolate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
19	T	t	PROPN	NNP	Number=Sing	_	_	_	_
20	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
21	and	and	CCONJ	CC	_	_	_	_	_
22	DCs	DC	NOUN	NNS	Number=Plur	_	_	_	_
23	from	from	ADP	IN	_	_	_	_	_
24	humans	human	NOUN	NNS	Number=Plur	_	_	_	_
25	and	and	CCONJ	CC	_	_	_	_	_
26	mice	mouse	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
27	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 720
# text = We have used immunolabeling, Western blot analysis, and electrophoretic mobility shift and supershift assays.
1	We	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
2	have	have	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
3	used	use	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
4	immunolabeling	immunolabeling	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
5	,	,	PUNCT	,	_	_	_	_	_
6	Western	western	ADJ	JJ	Degree=Pos	_	_	_	_
7	blot	blot	NOUN	NN	Number=Sing	_	_	_	_
8	analysis	analysis	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
9	,	,	PUNCT	,	_	_	_	_	_
10	and	and	CCONJ	CC	_	_	_	_	_
11	electrophoretic	electrophoretic	ADJ	JJ	Degree=Pos	_	_	_	_
12	mobility	mobility	NOUN	NN	Number=Sing	_	_	_	_
13	shift	shift	NOUN	NN	Number=Sing	_	_	_	_
14	and	and	CCONJ	CC	_	_	_	_	_
15	supershift	supershift	NOUN	NN	Number=Sing	_	_	_	_
16	assays	assay	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
17	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 721
# text = T cells lack active NF-kappa B but express Sp1 as expected.
1	T	t	PROPN	NNP	Number=Sing	_	_	_	_
2	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
3	lack	lack	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
4	active	active	ADJ	JJ	Degree=Pos	_	_	_	_
5	NF	Nf	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
6	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
7	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_
8	B	b	NOUN	NN	Number=Sing	_	_	_	_
9	but	but	CCONJ	CC	_	_	_	_	_
10	express	express	ADJ	JJ	Degree=Pos	_	_	_	_
11	Sp1	sp1	NOUN	NN	Number=Sing	_	_	_	_
12	as	as	SCONJ	IN	_	_	_	_	_
13	expected	expect	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	SpaceAfter=No
14	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 722
# text = DCs express high levels of all known NF-kappa B and Rel proteins, with activity residing primarily within RelB, p50, and p65.
1	DCs	DC	NOUN	NNS	Number=Plur	_	_	_	_
2	express	express	ADJ	JJ	Degree=Pos	_	_	_	_
3	high	high	ADJ	JJ	Degree=Pos	_	_	_	_
4	levels	level	NOUN	NNS	Number=Plur	_	_	_	_
5	of	of	ADP	IN	_	_	_	_	_
6	all	all	DET	DT	_	_	_	_	_
7	known	know	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
8	NF	Nf	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
9	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
10	kappa	kappa	PROPN	NNP	Number=Sing	_	_	_	_
11	B	b	PROPN	NNP	Number=Sing	_	_	_	_
12	and	and	CCONJ	CC	_	_	_	_	_
13	Rel	Rel	PROPN	NNP	Number=Sing	_	_	_	_
14	proteins	protein	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
15	,	,	PUNCT	,	_	_	_	_	_
16	with	with	SCONJ	IN	_	_	_	_	_
17	activity	activity	NOUN	NN	Number=Sing	_	_	_	_
18	residing	reside	VERB	VBG	VerbForm=Ger	_	_	_	_
19	primarily	primarily	ADV	RB	_	_	_	_	_
20	within	within	ADP	IN	_	_	_	_	_
21	RelB	RelB	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
22	,	,	PUNCT	,	_	_	_	_	_
23	p50	p50	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
24	,	,	PUNCT	,	_	_	_	_	_
25	and	and	CCONJ	CC	_	_	_	_	_
26	p65	p65	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
27	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 723
# text = However, DCs lack Sp1, which may explain the failure of HIV-1 to replicate in purified DCs.
1	However	however	ADV	RB	_	_	_	_	SpaceAfter=No
2	,	,	PUNCT	,	_	_	_	_	_
3	DCs	Dcs	PROPN	NNP	Number=Sing	_	_	_	_
4	lack	lack	NOUN	NN	Number=Sing	_	_	_	_
5	Sp1	Sp1	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
6	,	,	PUNCT	,	_	_	_	_	_
7	which	which	PRON	WDT	PronType=Rel	_	_	_	_
8	may	may	AUX	MD	VerbForm=Fin	_	_	_	_
9	explain	explain	VERB	VB	VerbForm=Inf	_	_	_	_
10	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
11	failure	failure	NOUN	NN	Number=Sing	_	_	_	_
12	of	of	ADP	IN	_	_	_	_	_
13	HIV	HIV	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
14	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
15	1	1	NUM	CD	NumType=Card	_	_	_	_
16	to	to	PART	TO	_	_	_	_	_
17	replicate	replicate	VERB	VB	VerbForm=Inf	_	_	_	_
18	in	in	ADP	IN	_	_	_	_	_
19	purified	purify	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
20	DCs	DC	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
21	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 724
# text = Coexpression of NF-kappa B and Sp1 occurs in the heterologous DC-T-cell syncytia that are induced by HIV-1.
1	Coexpression	Coexpression	NOUN	NN	Number=Sing	_	_	_	_
2	of	of	ADP	IN	_	_	_	_	_
3	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
4	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
5	kappa	kappa	PROPN	NNP	Number=Sing	_	_	_	_
6	B	b	PROPN	NNP	Number=Sing	_	_	_	_
7	and	and	CCONJ	CC	_	_	_	_	_
8	Sp1	sp1	NUM	CD	NumType=Card	_	_	_	_
9	occurs	occur	NOUN	NNS	Number=Plur	_	_	_	_
10	in	in	ADP	IN	_	_	_	_	_
11	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
12	heterologous	heterologous	ADJ	JJ	Degree=Pos	_	_	_	_
13	DC	DC	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
14	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
15	T	T	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
16	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
17	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
18	syncytia	syncytia	NOUN	NN	Number=Sing	_	_	_	_
19	that	that	PRON	WDT	PronType=Rel	_	_	_	_
20	are	be	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
21	induced	induce	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
22	by	by	ADP	IN	_	_	_	_	_
23	HIV	HIV	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
24	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
25	1	1	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
26	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 725
# text = Therefore, HIV-1-induced cell fusion brings together factors that upregulate virus transcription.
1	Therefore	therefore	ADV	RB	_	_	_	_	SpaceAfter=No
2	,	,	PUNCT	,	_	_	_	_	_
3	HIV	HIV	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
4	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
5	1	1	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
6	-induced	-induced	ADJ	JJ	Degree=Pos	_	_	_	_
7	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
8	fusion	fusion	NOUN	NN	Number=Sing	_	_	_	_
9	brings	bring	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
10	together	together	ADJ	JJ	Degree=Pos	_	_	_	_
11	factors	factor	NOUN	NNS	Number=Plur	_	_	_	_
12	that	that	PRON	WDT	PronType=Rel	_	_	_	_
13	upregulate	upregulate	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
14	virus	virus	NOUN	NN	Number=Sing	_	_	_	_
15	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
16	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 726
# text = Since DCs and memory T cells frequently traffic together in situ, these unusual heterologous syncytia could develop in infected individuals and lead to chronic HIV-1 replication without ostensible immune stimulation.
1	Since	since	SCONJ	IN	_	_	_	_	_
2	DCs	DC	NOUN	NNS	Number=Plur	_	_	_	_
3	and	and	CCONJ	CC	_	_	_	_	_
4	memory	memory	NOUN	NN	Number=Sing	_	_	_	_
5	T	t	PROPN	NNP	Number=Sing	_	_	_	_
6	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
7	frequently	frequently	ADV	RB	_	_	_	_	_
8	traffic	traffic	NOUN	NN	Number=Sing	_	_	_	_
9	together	together	ADV	RB	_	_	_	_	_
10	in	in	ADP	IN	_	_	_	_	_
11	situ	situ	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
12	,	,	PUNCT	,	_	_	_	_	_
13	these	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
14	unusual	unusual	ADJ	JJ	Degree=Pos	_	_	_	_
15	heterologous	heterologous	ADJ	JJ	Degree=Pos	_	_	_	_
16	syncytia	syncytia	NOUN	NN	Number=Sing	_	_	_	_
17	could	could	AUX	MD	VerbForm=Fin	_	_	_	_
18	develop	develop	VERB	VB	VerbForm=Inf	_	_	_	_
19	in	in	ADP	IN	_	_	_	_	_
20	infected	infected	ADJ	JJ	Degree=Pos	_	_	_	_
21	individuals	individual	NOUN	NNS	Number=Plur	_	_	_	_
22	and	and	CCONJ	CC	_	_	_	_	_
23	lead	lead	VERB	VB	VerbForm=Inf	_	_	_	_
24	to	to	ADP	IN	_	_	_	_	_
25	chronic	chronic	PROPN	NNP	Number=Sing	_	_	_	_
26	HIV	HIV	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
27	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
28	1	1	NUM	CD	NumType=Card	_	_	_	_
29	replication	replication	NOUN	NN	Number=Sing	_	_	_	_
30	without	without	ADP	IN	_	_	_	_	_
31	ostensible	ostensible	ADJ	JJ	Degree=Pos	_	_	_	_
32	immune	immune	ADJ	JJ	Degree=Pos	_	_	_	_
33	stimulation	stimulation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
34	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 727
# text = Document 003002252 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	003002252	003002252	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 728
# text = Possible differences in the mechanism(s) of action of different glucocorticoid hormone compounds.
1	Possible	possible	ADJ	JJ	Degree=Pos	_	_	_	_
2	differences	difference	NOUN	NNS	Number=Plur	_	_	_	_
3	in	in	ADP	IN	_	_	_	_	_
4	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
5	mechanism	mechanism	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
6	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
7	s	s	X	AFX	_	_	_	_	SpaceAfter=No
8	)	)	PUNCT	-RRB-	_	_	_	_	_
9	of	of	ADP	IN	_	_	_	_	_
10	action	action	NOUN	NN	Number=Sing	_	_	_	_
11	of	of	ADP	IN	_	_	_	_	_
12	different	different	ADJ	JJ	Degree=Pos	_	_	_	_
13	glucocorticoid	glucocorticoid	ADJ	JJ	Degree=Pos	_	_	_	_
14	hormone	hormone	NOUN	NN	Number=Sing	_	_	_	_
15	compounds	compound	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
16	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 729
# text = Different glucocorticoid hormones (GCH) show differences in the intensity and in the kinetics of their immunomodulating activity.
1	Different	different	ADJ	JJ	Degree=Pos	_	_	_	_
2	glucocorticoid	glucocorticoid	NOUN	NN	Number=Sing	_	_	_	_
3	hormones	hormone	NOUN	NNS	Number=Plur	_	_	_	_
4	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
5	GCH	GCH	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
6	)	)	PUNCT	-RRB-	_	_	_	_	_
7	show	show	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
8	differences	difference	NOUN	NNS	Number=Plur	_	_	_	_
9	in	in	ADP	IN	_	_	_	_	_
10	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
11	intensity	intensity	NOUN	NN	Number=Sing	_	_	_	_
12	and	and	CCONJ	CC	_	_	_	_	_
13	in	in	ADP	IN	_	_	_	_	_
14	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
15	kinetics	kinetic	NOUN	NNS	Number=Plur	_	_	_	_
16	of	of	ADP	IN	_	_	_	_	_
17	their	they	PRON	PRP$	Number=Plur|Person=3|Poss=Yes|PronType=Prs	_	_	_	_
18	immunomodulating	immunomodulating	ADJ	JJ	Degree=Pos	_	_	_	_
19	activity	activity	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
20	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 730
# text = The mechanism(s) of action of GCH is under investigation, but is has been noted that they exert immune activity via the genomic pathway.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	mechanism	mechanism	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
3	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
4	s	s	X	AFX	_	_	_	_	SpaceAfter=No
5	)	)	PUNCT	-RRB-	_	_	_	_	_
6	of	of	ADP	IN	_	_	_	_	_
7	action	action	NOUN	NN	Number=Sing	_	_	_	_
8	of	of	ADP	IN	_	_	_	_	_
9	GCH	GCH	PROPN	NNP	Number=Sing	_	_	_	_
10	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
11	under	under	ADP	IN	_	_	_	_	_
12	investigation	investigation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
13	,	,	PUNCT	,	_	_	_	_	_
14	but	but	CCONJ	CC	_	_	_	_	_
15	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
16	has	have	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
17	been	be	AUX	VBN	Tense=Past|VerbForm=Part	_	_	_	_
18	noted	note	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
19	that	that	SCONJ	IN	_	_	_	_	_
20	they	they	PRON	PRP	Case=Nom|Number=Plur|Person=3|PronType=Prs	_	_	_	_
21	exert	exert	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
22	immune	immune	ADJ	JJ	Degree=Pos	_	_	_	_
23	activity	activity	NOUN	NN	Number=Sing	_	_	_	_
24	via	via	ADP	IN	_	_	_	_	_
25	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
26	genomic	genomic	ADJ	JJ	Degree=Pos	_	_	_	_
27	pathway	pathway	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
28	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 731
# text = We have studied the effects of prednisone (PDN), deflazacort (DFC), and dexamethasone (DXM) on the production of cytokines (IL-2, IL-6, TNF-alpha, IL-10) by peripheral T lymphocytes, and the effects on the inhibition of NF-kB DNA binding activity by activated Jurkat cell line.
1	We	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
2	have	have	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
3	studied	studie	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
4	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
5	effects	effect	NOUN	NNS	Number=Plur	_	_	_	_
6	of	of	ADP	IN	_	_	_	_	_
7	prednisone	prednisone	NOUN	NN	Number=Sing	_	_	_	_
8	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
9	PDN	PDN	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
10	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
11	,	,	PUNCT	,	_	_	_	_	_
12	deflazacort	deflazacort	NOUN	NN	Number=Sing	_	_	_	_
13	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
14	DFC	DFC	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
15	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
16	,	,	PUNCT	,	_	_	_	_	_
17	and	and	CCONJ	CC	_	_	_	_	_
18	dexamethasone	dexamethasone	NOUN	NN	Number=Sing	_	_	_	_
19	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
20	DXM	DXM	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
21	)	)	PUNCT	-RRB-	_	_	_	_	_
22	on	on	ADP	IN	_	_	_	_	_
23	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
24	production	production	NOUN	NN	Number=Sing	_	_	_	_
25	of	of	ADP	IN	_	_	_	_	_
26	cytokines	cytokine	NOUN	NNS	Number=Plur	_	_	_	_
27	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
28	IL	Il	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
29	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
30	2	2	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
31	,	,	PUNCT	,	_	_	_	_	_
32	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
33	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
34	6	6	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
35	,	,	PUNCT	,	_	_	_	_	_
36	TNF	Tnf	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
37	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
38	alpha	alpha	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
39	,	,	PUNCT	,	_	_	_	_	_
40	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
41	-	-	SYM	SYM	_	_	_	_	SpaceAfter=No
42	10	10	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
43	)	)	PUNCT	-RRB-	_	_	_	_	_
44	by	by	ADP	IN	_	_	_	_	_
45	peripheral	peripheral	ADJ	JJ	Degree=Pos	_	_	_	_
46	T	t	PROPN	NNP	Number=Sing	_	_	_	_
47	lymphocytes	lymphocyte	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
48	,	,	PUNCT	,	_	_	_	_	_
49	and	and	CCONJ	CC	_	_	_	_	_
50	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
51	effects	effect	NOUN	NNS	Number=Plur	_	_	_	_
52	on	on	ADP	IN	_	_	_	_	_
53	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
54	inhibition	inhibition	NOUN	NN	Number=Sing	_	_	_	_
55	of	of	ADP	IN	_	_	_	_	_
56	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
57	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
58	kB	kb	PROPN	NNP	Number=Sing	_	_	_	_
59	DNA	dna	NOUN	NN	Number=Sing	_	_	_	_
60	binding	bind	VERB	VBG	VerbForm=Ger	_	_	_	_
61	activity	activity	NOUN	NN	Number=Sing	_	_	_	_
62	by	by	ADP	IN	_	_	_	_	_
63	activated	activated	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
64	Jurkat	Jurkat	PROPN	NNP	Number=Sing	_	_	_	_
65	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
66	line	line	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
67	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 732
# text = The data obtained show that the three GCH molecules exert an immunosuppression on cytokine production by T lymphocytes and a strong decrease in the nuclear translocation of NF-kB in Jurkat cells; moreover, (a) not all the cytokines investigated were affected, and not with the same intensity, by the three GCH and (b) DXM inhibited the binding activity of NF-kB less than that of DFC and PDN.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	data	data	NOUN	NN	Number=Sing	_	_	_	_
3	obtained	obtain	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
4	show	show	VERB	VB	VerbForm=Inf	_	_	_	_
5	that	that	SCONJ	IN	_	_	_	_	_
6	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
7	three	three	NUM	CD	NumType=Card	_	_	_	_
8	GCH	GCh	NOUN	NN	Number=Sing	_	_	_	_
9	molecules	molecule	NOUN	NNS	Number=Plur	_	_	_	_
10	exert	exert	ADP	IN	Typo=Yes	_	_	_	_
11	an	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
12	immunosuppression	immunosuppression	NOUN	NN	Number=Sing	_	_	_	_
13	on	on	ADP	IN	_	_	_	_	_
14	cytokine	cytokine	NOUN	NN	Number=Sing	_	_	_	_
15	production	production	NOUN	NN	Number=Sing	_	_	_	_
16	by	by	ADP	IN	_	_	_	_	_
17	T	T	PROPN	NNP	Number=Sing	_	_	_	_
18	lymphocytes	lymphocyte	NOUN	NNS	Number=Plur	_	_	_	_
19	and	and	CCONJ	CC	_	_	_	_	_
20	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
21	strong	strong	ADJ	JJ	Degree=Pos	_	_	_	_
22	decrease	decrease	NOUN	NN	Number=Sing	_	_	_	_
23	in	in	ADP	IN	_	_	_	_	_
24	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
25	nuclear	nuclear	ADJ	JJ	Degree=Pos	_	_	_	_
26	translocation	translocation	NOUN	NN	Number=Sing	_	_	_	_
27	of	of	ADP	IN	_	_	_	_	_
28	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
29	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
30	kB	kb	PROPN	NNP	Number=Sing	_	_	_	_
31	in	in	ADP	IN	_	_	_	_	_
32	Jurkat	Jurkat	PROPN	NNP	Number=Sing	_	_	_	_
33	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
34	;	;	PUNCT	,	_	_	_	_	_
35	moreover	moreover	ADV	RB	_	_	_	_	SpaceAfter=No
36	,	,	PUNCT	,	_	_	_	_	_
37	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
38	a	a	X	LS	_	_	_	_	SpaceAfter=No
39	)	)	PUNCT	-RRB-	_	_	_	_	_
40	not	not	ADV	RB	_	_	_	_	_
41	all	all	DET	PDT	_	_	_	_	_
42	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
43	cytokines	cytokine	NOUN	NNS	Number=Plur	_	_	_	_
44	investigated	investigate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
45	were	be	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
46	affected	affect	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	SpaceAfter=No
47	,	,	PUNCT	,	_	_	_	_	_
48	and	and	CCONJ	CC	_	_	_	_	_
49	not	not	ADV	RB	_	_	_	_	_
50	with	with	ADP	IN	_	_	_	_	_
51	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
52	same	same	ADJ	JJ	Degree=Pos	_	_	_	_
53	intensity	intensity	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
54	,	,	PUNCT	,	_	_	_	_	_
55	by	by	ADP	IN	_	_	_	_	_
56	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
57	three	three	NUM	CD	NumType=Card	_	_	_	_
58	GCH	GCh	NOUN	NN	Number=Sing	_	_	_	_
59	and	and	CCONJ	CC	_	_	_	_	_
60	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
61	b	b	X	LS	_	_	_	_	SpaceAfter=No
62	)	)	PUNCT	-RRB-	_	_	_	_	_
63	DXM	DXm	PRON	PRP	Case=Acc|Gender=Masc|Number=Sing|Person=3|PronType=Prs	_	_	_	_
64	inhibited	inhibit	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
65	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
66	binding	bind	VERB	VBG	VerbForm=Ger	_	_	_	_
67	activity	activity	NOUN	NN	Number=Sing	_	_	_	_
68	of	of	ADP	IN	_	_	_	_	_
69	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
70	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
71	kB	kb	PROPN	NNP	Number=Sing	_	_	_	_
72	less	less	ADJ	JJR	Degree=Cmp	_	_	_	_
73	than	than	ADP	IN	_	_	_	_	_
74	that	that	PRON	DT	Number=Sing|PronType=Dem	_	_	_	_
75	of	of	ADP	IN	_	_	_	_	_
76	DFC	DFC	PROPN	NNP	Number=Sing	_	_	_	_
77	and	and	CCONJ	CC	_	_	_	_	_
78	PDN	PDN	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
79	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 733
# text = These data are in agreement with the concept that different GCH compounds might differ in their binding and affinity properties, tissue-specific metabolism, and interaction with transcription factor.
1	These	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
2	data	data	NOUN	NN	Number=Sing	_	_	_	_
3	are	be	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
4	in	in	ADP	IN	_	_	_	_	_
5	agreement	agreement	NOUN	NN	Number=Sing	_	_	_	_
6	with	with	ADP	IN	_	_	_	_	_
7	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
8	concept	concept	NOUN	NN	Number=Sing	_	_	_	_
9	that	that	ADV	WRB	PronType=Rel	_	_	_	_
10	different	different	ADJ	JJ	Degree=Pos	_	_	_	_
11	GCH	GCh	NOUN	NN	Number=Sing	_	_	_	_
12	compounds	compound	NOUN	NNS	Number=Plur	_	_	_	_
13	might	might	AUX	MD	VerbForm=Fin	_	_	_	_
14	differ	differ	VERB	VB	VerbForm=Inf	_	_	_	_
15	in	in	ADP	IN	_	_	_	_	_
16	their	they	PRON	PRP$	Number=Plur|Person=3|Poss=Yes|PronType=Prs	_	_	_	_
17	binding	binding	NOUN	NN	Number=Sing	_	_	_	_
18	and	and	CCONJ	CC	_	_	_	_	_
19	affinity	affinity	NOUN	NN	Number=Sing	_	_	_	_
20	properties	property	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
21	,	,	PUNCT	,	_	_	_	_	_
22	tissue-	tissue-	SYM	NFP	_	_	_	_	SpaceAfter=No
23	specific	specific	ADJ	JJ	Degree=Pos	_	_	_	_
24	metabolism	metabolism	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
25	,	,	PUNCT	,	_	_	_	_	_
26	and	and	CCONJ	CC	_	_	_	_	_
27	interaction	interaction	NOUN	NN	Number=Sing	_	_	_	_
28	with	with	ADP	IN	_	_	_	_	_
29	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
30	factor	factor	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
31	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 734
# text = Document 003002253 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	003002253	003002253	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 735
# text = Abnormal NF-kappa B activity in T lymphocytes from patients with systemic lupus erythematosus is associated with decreased p65-RelA protein expression.
1	Abnormal	abnormal	PROPN	NNP	Number=Sing	_	_	_	_
2	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
3	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
4	kappa	kappa	X	FW	Foreign=Yes	_	_	_	_
5	B	b	ADJ	JJ	Degree=Pos	_	_	_	_
6	activity	activity	NOUN	NN	Number=Sing	_	_	_	_
7	in	in	ADP	IN	_	_	_	_	_
8	T	t	PROPN	NNP	Number=Sing	_	_	_	_
9	lymphocytes	lymphocyte	NOUN	NNS	Number=Plur	_	_	_	_
10	from	from	ADP	IN	_	_	_	_	_
11	patients	patient	NOUN	NNS	Number=Plur	_	_	_	_
12	with	with	ADP	IN	_	_	_	_	_
13	systemic	systemic	ADJ	JJ	Degree=Pos	_	_	_	_
14	lupus	lupus	NOUN	NN	Number=Sing	_	_	_	_
15	erythematosus	erythematosus	NOUN	NN	Number=Sing	_	_	_	_
16	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
17	associated	associate	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
18	with	with	ADP	IN	_	_	_	_	_
19	decreased	decrease	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
20	p65	p65	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
21	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
22	RelA	Rela	NOUN	NN	Number=Sing	_	_	_	_
23	protein	protein	NOUN	NN	Number=Sing	_	_	_	_
24	expression	expression	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
25	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 736
# text = Numerous cellular and biochemical abnormalities in immune regulation have been described in patients with systemic lupus erythematosus (SLE), including surface
1	Numerous	numerous	ADJ	JJ	Degree=Pos	_	_	_	_
2	cellular	cellular	ADJ	JJ	Degree=Pos	_	_	_	_
3	and	and	CCONJ	CC	_	_	_	_	_
4	biochemical	biochemical	ADJ	JJ	Degree=Pos	_	_	_	_
5	abnormalities	abnormality	NOUN	NNS	Number=Plur	_	_	_	_
6	in	in	ADP	IN	_	_	_	_	_
7	immune	immune	ADJ	JJ	Degree=Pos	_	_	_	_
8	regulation	regulation	NOUN	NN	Number=Sing	_	_	_	_
9	have	have	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
10	been	be	AUX	VBN	Tense=Past|VerbForm=Part	_	_	_	_
11	described	describe	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
12	in	in	ADP	IN	_	_	_	_	_
13	patients	patient	NOUN	NN	Number=Sing	_	_	_	_
14	with	with	ADP	IN	_	_	_	_	_
15	systemic	systemic	ADJ	JJ	Degree=Pos	_	_	_	_
16	lupus	lupus	NOUN	NN	Number=Sing	_	_	_	_
17	erythematosus	erythematosus	NOUN	NN	Number=Sing	_	_	_	_
18	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
19	SLE	Sle	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
20	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
21	,	,	PUNCT	,	_	_	_	_	_
22	including	include	VERB	VBG	VerbForm=Ger	_	_	_	_
23	surface	surface	NOUN	NN	Number=Sing	_	_	_	_

# sent_id = 737
# text = Ag receptor-initiated signaling events and lymphokine production.
1	Ag	ag	VERB	VB	Mood=Imp|VerbForm=Fin	_	_	_	_
2	receptor	receptor	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
3	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
4	initiated	initiate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
5	signaling	signaling	VERB	VBG	VerbForm=Ger	_	_	_	_
6	events	event	NOUN	NNS	Number=Plur	_	_	_	_
7	and	and	CCONJ	CC	_	_	_	_	_
8	lymphokine	lymphokine	NOUN	NN	Number=Sing	_	_	_	_
9	production	production	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
10	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 738
# text = Because NF-kappa B contributes to the transcription of numerous inflammatory genes and has been shown to be a molecular target of antiinflammatory drugs, we sought to characterize the functional role of the NF-kappa B protein complex in lupus T cells.
1	Because	because	SCONJ	IN	_	_	_	_	_
2	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
3	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
4	kappa	kappa	PROPN	NNP	Number=Sing	_	_	_	_
5	B	b	PROPN	NNP	Number=Sing	_	_	_	_
6	contributes	contribute	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
7	to	to	ADP	IN	_	_	_	_	_
8	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
9	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
10	of	of	ADP	IN	_	_	_	_	_
11	numerous	numerous	ADJ	JJ	Degree=Pos	_	_	_	_
12	inflammatory	inflammatory	ADJ	JJ	Degree=Pos	_	_	_	_
13	genes	gene	NOUN	NNS	Number=Plur	_	_	_	_
14	and	and	CCONJ	CC	_	_	_	_	_
15	has	have	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
16	been	be	AUX	VBN	Tense=Past|VerbForm=Part	_	_	_	_
17	shown	show	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
18	to	to	PART	TO	_	_	_	_	_
19	be	be	AUX	VB	VerbForm=Inf	_	_	_	_
20	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
21	molecular	molecular	ADJ	JJ	Degree=Pos	_	_	_	_
22	target	target	NOUN	NN	Number=Sing	_	_	_	_
23	of	of	ADP	IN	_	_	_	_	_
24	antiinflammatory	antiinflammatory	ADJ	JJ	Degree=Pos	_	_	_	_
25	drugs	drug	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
26	,	,	PUNCT	,	_	_	_	_	_
27	we	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
28	sought	seek	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
29	to	to	PART	TO	_	_	_	_	_
30	characterize	characterize	VERB	VB	VerbForm=Inf	_	_	_	_
31	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
32	functional	functional	ADJ	JJ	Degree=Pos	_	_	_	_
33	role	role	NOUN	NN	Number=Sing	_	_	_	_
34	of	of	ADP	IN	_	_	_	_	_
35	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
36	NF	Nf	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
37	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
38	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_
39	B	b	NOUN	NN	Number=Sing	_	_	_	_
40	protein	protein	NOUN	NN	Number=Sing	_	_	_	_
41	complex	complex	NOUN	NN	Number=Sing	_	_	_	_
42	in	in	ADP	IN	_	_	_	_	_
43	lupus	lupus	ADJ	JJ	Degree=Pos	_	_	_	_
44	T	t	PROPN	NNP	Number=Sing	_	_	_	_
45	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
46	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 739
# text = Freshly isolated T cells from lupus patients, rheumatoid arthritis (RA) patients, and normal individuals were activated physiologically via the TCR with anti-CD3 and anti-CD28
1	Freshly	freshly	ADV	RB	_	_	_	_	_
2	isolated	isolate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
3	T	t	PROPN	NNP	Number=Sing	_	_	_	_
4	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
5	from	from	ADP	IN	_	_	_	_	_
6	lupus	lupus	NOUN	NN	Number=Sing	_	_	_	_
7	patients	patient	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
8	,	,	PUNCT	,	_	_	_	_	_
9	rheumatoid	rheumatoid	ADJ	JJ	Degree=Pos	_	_	_	_
10	arthritis	arthritis	NOUN	NN	Number=Sing	_	_	_	_
11	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
12	RA	RA	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
13	)	)	PUNCT	-RRB-	_	_	_	_	_
14	patients	patient	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
15	,	,	PUNCT	,	_	_	_	_	_
16	and	and	CCONJ	CC	_	_	_	_	_
17	normal	normal	ADJ	JJ	Degree=Pos	_	_	_	_
18	individuals	individual	NOUN	NNS	Number=Plur	_	_	_	_
19	were	be	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
20	activated	activate	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
21	physiologically	physiologically	ADV	RB	_	_	_	_	_
22	via	via	ADP	IN	_	_	_	_	_
23	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
24	TCR	Tcr	NOUN	NN	Number=Sing	_	_	_	_
25	with	with	ADP	IN	_	_	_	_	_
26	anti-CD3	anti-CD3	NUM	CD	NumType=Card	_	_	_	_
27	and	and	CCONJ	CC	_	_	_	_	_
28	anti-CD28	anti-CD28	NUM	CD	NumType=Card	_	_	_	_

# sent_id = 740
# text = Abs to assess proximal membrane signaling, and with PMA and a calcium ionophore (A23187) to bypass membrane-mediated signaling events.
1	Abs	Ab	NOUN	NNS	Number=Plur	_	_	_	_
2	to	to	PART	TO	_	_	_	_	_
3	assess	assess	VERB	VB	VerbForm=Inf	_	_	_	_
4	proximal	proximal	ADJ	JJ	Degree=Pos	_	_	_	_
5	membrane	membrane	NOUN	NN	Number=Sing	_	_	_	_
6	signaling	signaling	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
7	,	,	PUNCT	,	_	_	_	_	_
8	and	and	CCONJ	CC	_	_	_	_	_
9	with	with	ADP	IN	_	_	_	_	_
10	PMA	Pma	PROPN	NNP	Number=Sing	_	_	_	_
11	and	and	CCONJ	CC	_	_	_	_	_
12	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
13	calcium	calcium	NOUN	NN	Number=Sing	_	_	_	_
14	ionophore	ionophore	NOUN	NN	Number=Sing	_	_	_	_
15	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
16	A23187	A23187	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
17	)	)	PUNCT	-RRB-	_	_	_	_	_
18	to	to	PART	TO	_	_	_	_	_
19	bypass	bypass	VERB	VB	VerbForm=Inf	_	_	_	_
20	membrane	membrane	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
21	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
22	mediated	mediate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
23	signaling	signaling	NOUN	NN	Number=Sing	_	_	_	_
24	events	event	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
25	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 741
# text = We measured the NF-kappa B binding activity in nuclear extracts by gel shift analysis.
1	We	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
2	measured	measure	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
3	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
4	NF	Nf	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
5	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
6	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_
7	B	b	NOUN	NN	Number=Sing	_	_	_	_
8	binding	binde	VERB	VBG	VerbForm=Ger	_	_	_	_
9	activity	activity	NOUN	NN	Number=Sing	_	_	_	_
10	in	in	ADP	IN	_	_	_	_	_
11	nuclear	nuclear	ADJ	JJ	Degree=Pos	_	_	_	_
12	extracts	extract	NOUN	NNS	Number=Plur	_	_	_	_
13	by	by	ADP	IN	_	_	_	_	_
14	gel	gel	NOUN	NN	Number=Sing	_	_	_	_
15	shift	shift	NOUN	NN	Number=Sing	_	_	_	_
16	analysis	analysis	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
17	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 742
# text = When compared with normal cells, the activation of NF-kappa B activity in SLE patients was significantly decreased in SLE, but not in RA, patients.
1	When	when	ADV	WRB	PronType=Int	_	_	_	_
2	compared	compare	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
3	with	with	ADP	IN	_	_	_	_	_
4	normal	normal	ADJ	JJ	Degree=Pos	_	_	_	_
5	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
6	,	,	PUNCT	,	_	_	_	_	_
7	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
8	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
9	of	of	ADP	IN	_	_	_	_	_
10	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
11	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
12	kappa	kappa	PROPN	NNP	Number=Sing	_	_	_	_
13	B	b	PROPN	NNP	Number=Sing	_	_	_	_
14	activity	activity	NOUN	NN	Number=Sing	_	_	_	_
15	in	in	ADP	IN	_	_	_	_	_
16	SLE	Sle	ADJ	JJ	Degree=Pos	_	_	_	_
17	patients	patient	NOUN	NNS	Number=Plur	_	_	_	_
18	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
19	significantly	significantly	ADV	RB	_	_	_	_	_
20	decreased	decrease	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
21	in	in	ADP	IN	_	_	_	_	_
22	SLE	SLE	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
23	,	,	PUNCT	,	_	_	_	_	_
24	but	but	CCONJ	CC	_	_	_	_	_
25	not	not	ADV	RB	_	_	_	_	_
26	in	in	ADP	IN	_	_	_	_	_
27	RA	RA	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
28	,	,	PUNCT	,	_	_	_	_	_
29	patients	patient	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
30	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 743
# text = NF-kappa B binding activity was absent in several SLE patients who were not receiving any medication, including corticosteroids.
1	NF	Nf	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
2	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
3	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_
4	B	b	NOUN	NN	Number=Sing	_	_	_	_
5	binding	binde	VERB	VBG	VerbForm=Ger	_	_	_	_
6	activity	activity	NOUN	NN	Number=Sing	_	_	_	_
7	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
8	absent	absend	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
9	in	in	ADP	IN	_	_	_	_	_
10	several	several	ADJ	JJ	Degree=Pos	_	_	_	_
11	SLE	Sle	PROPN	NNP	Number=Sing	_	_	_	_
12	patients	patient	NOUN	NNS	Number=Plur	_	_	_	_
13	who	who	PRON	WP	PronType=Rel	_	_	_	_
14	were	be	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
15	not	not	PART	RB	_	_	_	_	_
16	receiving	receive	VERB	VBG	Tense=Pres|VerbForm=Part	_	_	_	_
17	any	any	DET	DT	_	_	_	_	_
18	medication	medication	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
19	,	,	PUNCT	,	_	_	_	_	_
20	including	include	VERB	VBG	VerbForm=Ger	_	_	_	_
21	corticosteroids	corticosteroid	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
22	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 744
# text = Also, NF-kappa B activity remained absent in follow-up studies.
1	Also	also	ADV	RB	_	_	_	_	SpaceAfter=No
2	,	,	PUNCT	,	_	_	_	_	_
3	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
4	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
5	kappa	kappa	PROPN	NNP	Number=Sing	_	_	_	_
6	B	b	PROPN	NNP	Number=Sing	_	_	_	_
7	activity	activity	NOUN	NN	Number=Sing	_	_	_	_
8	remained	remain	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
9	absent	absent	NOUN	NN	Number=Sing	_	_	_	_
10	in	in	ADP	IN	_	_	_	_	_
11	follow	follow	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
12	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
13	up	up	NOUN	NN	Number=Sing	_	_	_	_
14	studies	study	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
15	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 745
# text = In supershift experiments using specific Abs, we showed that, in the group of SLE patients who displayed undetectable NF-kappa B activity, p65 complexes were not formed.
1	In	in	ADP	IN	_	_	_	_	_
2	supershift	supershift	ADJ	JJ	Degree=Pos	_	_	_	_
3	experiments	experiment	NOUN	NNS	Number=Plur	_	_	_	_
4	using	use	VERB	VBG	VerbForm=Ger	_	_	_	_
5	specific	specific	ADJ	JJ	Degree=Pos	_	_	_	_
6	Abs	Ab	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
7	,	,	PUNCT	,	_	_	_	_	_
8	we	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
9	showed	show	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
10	that	that	PRON	DT	Number=Sing|PronType=Dem	_	_	_	SpaceAfter=No
11	,	,	PUNCT	,	_	_	_	_	_
12	in	in	ADP	IN	_	_	_	_	_
13	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
14	group	group	NOUN	NN	Number=Sing	_	_	_	_
15	of	of	ADP	IN	_	_	_	_	_
16	SLE	Sle	ADJ	JJ	Degree=Pos	_	_	_	_
17	patients	patient	NOUN	NNS	Number=Plur	_	_	_	_
18	who	who	PRON	WP	PronType=Rel	_	_	_	_
19	displayed	display	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
20	undetectable	undetectable	ADJ	JJ	Degree=Pos	_	_	_	_
21	NF	Nf	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
22	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
23	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_
24	B	b	NOUN	NN	Number=Sing	_	_	_	_
25	activity	activity	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
26	,	,	PUNCT	,	_	_	_	_	_
27	p65	p65	NUM	CD	NumType=Card	_	_	_	_
28	complexes	complexe	NOUN	NNS	Number=Plur	_	_	_	_
29	were	be	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
30	not	not	PART	RB	_	_	_	_	_
31	formed	form	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	SpaceAfter=No
32	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 746
# text = Finally, immunoblot analysis of nuclear extracts showed decreased or absent p65 protein levels.
1	Finally	finally	ADV	RB	_	_	_	_	SpaceAfter=No
2	,	,	PUNCT	,	_	_	_	_	_
3	immunoblot	immunoblot	ADJ	JJ	Degree=Pos	_	_	_	_
4	analysis	analysis	NOUN	NN	Number=Sing	_	_	_	_
5	of	of	ADP	IN	_	_	_	_	_
6	nuclear	nuclear	ADJ	JJ	Degree=Pos	_	_	_	_
7	extracts	extract	NOUN	NNS	Number=Plur	_	_	_	_
8	showed	show	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
9	decreased	decrease	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
10	or	or	CCONJ	CC	_	_	_	_	_
11	absent	absent	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
12	p65	p65	NUM	CD	NumType=Card	_	_	_	_
13	protein	protein	NOUN	NN	Number=Sing	_	_	_	_
14	levels	level	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
15	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 747
# text = As p65 complexes are transcriptionally active in comparison to the p50 homodimer, this novel finding may provide insight on the origin of abnormal cytokine or other gene transcription in SLE patients.
1	As	as	ADP	IN	_	_	_	_	_
2	p65	p65	NUM	CD	NumType=Card	_	_	_	_
3	complexes	complexe	NOUN	NNS	Number=Plur	_	_	_	_
4	are	be	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
5	transcriptionally	transcriptionally	ADV	RB	_	_	_	_	_
6	active	active	ADJ	JJ	Degree=Pos	_	_	_	_
7	in	in	ADP	IN	_	_	_	_	_
8	comparison	comparison	NOUN	NN	Number=Sing	_	_	_	_
9	to	to	ADP	IN	_	_	_	_	_
10	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
11	p50	p50	NOUN	NN	Number=Sing	_	_	_	_
12	homodimer	homodimer	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
13	,	,	PUNCT	,	_	_	_	_	_
14	this	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
15	novel	novel	NOUN	NN	Number=Sing	_	_	_	_
16	finding	finding	NOUN	NN	Number=Sing	_	_	_	_
17	may	may	AUX	MD	VerbForm=Fin	_	_	_	_
18	provide	provide	VERB	VB	VerbForm=Inf	_	_	_	_
19	insight	insight	NOUN	NN	Number=Sing	_	_	_	_
20	on	on	ADP	IN	_	_	_	_	_
21	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
22	origin	origin	NOUN	NN	Number=Sing	_	_	_	_
23	of	of	ADP	IN	_	_	_	_	_
24	abnormal	abnormal	ADJ	JJ	Degree=Pos	_	_	_	_
25	cytokine	cytokine	NOUN	NN	Number=Sing	_	_	_	_
26	or	or	CCONJ	CC	_	_	_	_	_
27	other	other	ADJ	JJ	Degree=Pos	_	_	_	_
28	gene	gene	ADJ	JJ	Degree=Pos	_	_	_	_
29	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
30	in	in	ADP	IN	_	_	_	_	_
31	SLE	Sle	ADJ	JJ	Degree=Pos	_	_	_	_
32	patients	patient	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
33	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 748
# text = Document 003002268 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	003002268	003002268	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 749
# text = Apoptosis-resistant T cells have a deficiency in NF-kappaB-mediated induction of Fas ligand transcription.
1	Apoptosis	Apoptosis	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
2	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
3	resistant	resistant	ADJ	JJ	Degree=Pos	_	_	_	_
4	T	t	PROPN	NNP	Number=Sing	_	_	_	_
5	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
6	have	have	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
7	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
8	deficiency	deficiency	NOUN	NN	Number=Sing	_	_	_	_
9	in	in	ADP	IN	_	_	_	_	_
10	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
11	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
12	kappaB-	kappaB-	SYM	SYM	_	_	_	_	SpaceAfter=No
13	mediated	mediated	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
14	induction	induction	NOUN	NN	Number=Sing	_	_	_	_
15	of	of	ADP	IN	_	_	_	_	_
16	Fas	Fas	PROPN	NNP	Number=Sing	_	_	_	_
17	ligand	ligand	NOUN	NN	Number=Sing	_	_	_	_
18	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
19	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 750
# text = Apoptosis induced through the TCR in CD4+ T cells is mostly mediated by the inducible expression of Fas ligand (FasL) as a primary event leading to the commitment to death.
1	Apoptosis	Apoptosis	PROPN	NNP	Number=Sing	_	_	_	_
2	induced	induce	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
3	through	through	ADP	IN	_	_	_	_	_
4	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
5	TCR	Tcr	NOUN	NN	Number=Sing	_	_	_	_
6	in	in	ADP	IN	_	_	_	_	_
7	CD4	CD4	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
8	+	+	SYM	SYM	_	_	_	_	_
9	T	t	NUM	CD	NumType=Card	_	_	_	_
10	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
11	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
12	mostly	mostly	ADV	RB	_	_	_	_	_
13	mediated	mediate	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
14	by	by	ADP	IN	_	_	_	_	_
15	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
16	inducible	inducible	ADJ	JJ	Degree=Pos	_	_	_	_
17	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
18	of	of	ADP	IN	_	_	_	_	_
19	Fas	Fas	PROPN	NNPS	Number=Plur	_	_	_	_
20	ligand	ligand	NOUN	NN	Number=Sing	_	_	_	_
21	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
22	FasL	Fasl	INTJ	UH	_	_	_	_	SpaceAfter=No
23	)	)	PUNCT	-RRB-	_	_	_	_	_
24	as	as	ADP	IN	_	_	_	_	_
25	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
26	primary	primary	ADJ	JJ	Degree=Pos	_	_	_	_
27	event	event	NOUN	NN	Number=Sing	_	_	_	_
28	leading	lead	VERB	VBG	VerbForm=Ger	_	_	_	_
29	to	to	ADP	IN	_	_	_	_	_
30	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
31	commitment	commitment	NOUN	NN	Number=Sing	_	_	_	_
32	to	to	ADP	IN	_	_	_	_	_
33	death	death	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
34	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 751
# text = To gain a better understanding of the transcriptional events that regulate this expression, we took advantage of our previously described mutant Jurkat cells.
1	To	to	PART	TO	_	_	_	_	_
2	gain	gain	VERB	VB	VerbForm=Inf	_	_	_	_
3	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
4	better	better	ADJ	JJR	Degree=Cmp	_	_	_	_
5	understanding	understanding	NOUN	NN	Number=Sing	_	_	_	_
6	of	of	ADP	IN	_	_	_	_	_
7	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
8	transcriptional	transcriptional	ADJ	JJ	Degree=Pos	_	_	_	_
9	events	event	NOUN	NNS	Number=Plur	_	_	_	_
10	that	that	PRON	WDT	PronType=Rel	_	_	_	_
11	regulate	regulate	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
12	this	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
13	expression	expression	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
14	,	,	PUNCT	,	_	_	_	_	_
15	we	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
16	took	take	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
17	advantage	advantage	NOUN	NN	Number=Sing	_	_	_	_
18	of	of	ADP	IN	_	_	_	_	_
19	our	we	PRON	PRP$	Number=Plur|Person=1|Poss=Yes|PronType=Prs	_	_	_	_
20	previously	previously	ADV	RB	_	_	_	_	_
21	described	describe	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
22	mutant	mutant	ADJ	JJ	Degree=Pos	_	_	_	_
23	Jurkat	Jurkat	PROPN	NNP	Number=Sing	_	_	_	_
24	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
25	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 752
# text = These cells are deficient in FasL expression and apoptosis induced upon TCR triggering, although their cytokine (IL-2 and IFN-gamma) production is normal.
1	These	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
2	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
3	are	be	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
4	deficient	deficient	ADJ	JJ	Degree=Pos	_	_	_	_
5	in	in	ADP	IN	_	_	_	_	_
6	FasL	Fasl	ADJ	JJ	Degree=Pos	_	_	_	_
7	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
8	and	and	CCONJ	CC	_	_	_	_	_
9	apoptosis	apoptosis	NOUN	NN	Number=Sing	_	_	_	_
10	induced	induce	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
11	upon	upon	ADP	IN	_	_	_	_	_
12	TCR	Tcr	NOUN	NN	Number=Sing	_	_	_	_
13	triggering	triggering	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
14	,	,	PUNCT	,	_	_	_	_	_
15	although	although	SCONJ	IN	_	_	_	_	_
16	their	they	PRON	PRP$	Number=Plur|Person=3|Poss=Yes|PronType=Prs	_	_	_	_
17	cytokine	cytokine	NOUN	NN	Number=Sing	_	_	_	_
18	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
19	IL	Il	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
20	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
21	2	2	NUM	CD	NumType=Card	_	_	_	_
22	and	and	CCONJ	CC	_	_	_	_	_
23	IFN	Ifn	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
24	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
25	gamma	gamma	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
26	)	)	PUNCT	-RRB-	_	_	_	_	_
27	production	production	NOUN	NN	Number=Sing	_	_	_	_
28	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
29	normal	normal	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
30	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 753
# text = Here we show that both a FasL- and a consensus NF-kappaB- reporter construct are inefficiently induced in these cells compared to wild-type cells.
1	Here	here	ADV	RB	PronType=Dem	_	_	_	_
2	we	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
3	show	show	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
4	that	that	SCONJ	IN	_	_	_	_	_
5	both	both	DET	DT	_	_	_	_	_
6	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
7	FasL	Fasl	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
8	-	-	PUNCT	,	_	_	_	_	_
9	and	and	CCONJ	CC	_	_	_	_	_
10	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
11	consensus	consensus	NOUN	NN	Number=Sing	_	_	_	_
12	NF	NF	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
13	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
14	kappaB	kappaB	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
15	-	-	PUNCT	HYPH	_	_	_	_	_
16	reporter	reporter	NOUN	NN	Number=Sing	_	_	_	_
17	construct	construct	NOUN	NN	Number=Sing	_	_	_	_
18	are	be	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
19	inefficiently	inefficiently	ADV	RB	_	_	_	_	_
20	induced	induce	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
21	in	in	ADP	IN	_	_	_	_	_
22	these	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
23	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
24	compared	compare	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
25	to	to	ADP	IN	_	_	_	_	_
26	wild	wild	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
27	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
28	type	type	NOUN	NN	Number=Sing	_	_	_	_
29	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
30	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 754
# text = In addition, we demonstrate that the inducible transcriptional activity of the FasL reporter is abolished by specific inhibitors of NF-kappaB activation.
1	In	in	ADP	IN	_	_	_	_	_
2	addition	addition	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
3	,	,	PUNCT	,	_	_	_	_	_
4	we	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
5	demonstrate	demonstrate	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
6	that	that	SCONJ	IN	_	_	_	_	_
7	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
8	inducible	inducible	ADJ	JJ	Degree=Pos	_	_	_	_
9	transcriptional	transcriptional	ADJ	JJ	Degree=Pos	_	_	_	_
10	activity	activity	NOUN	NN	Number=Sing	_	_	_	_
11	of	of	ADP	IN	_	_	_	_	_
12	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
13	FasL	Fasl	ADJ	JJ	Degree=Pos	_	_	_	_
14	reporter	reporter	NOUN	NN	Number=Sing	_	_	_	_
15	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
16	abolished	abolish	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
17	by	by	ADP	IN	_	_	_	_	_
18	specific	specific	ADJ	JJ	Degree=Pos	_	_	_	_
19	inhibitors	inhibitor	NOUN	NNS	Number=Plur	_	_	_	_
20	of	of	ADP	IN	_	_	_	_	_
21	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
22	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
23	kappaB	kappaB	PROPN	NNP	Number=Sing	_	_	_	_
24	activation	activation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
25	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 755
# text = Thus, we could trace the deficit of the mutant cells to an inefficient NF-kappaB activation, evidencing a relevant role for NF-kappaB in the regulation of FasL expression in activated T cells.
1	Thus	thus	ADV	RB	_	_	_	_	SpaceAfter=No
2	,	,	PUNCT	,	_	_	_	_	_
3	we	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
4	could	could	AUX	MD	VerbForm=Fin	_	_	_	_
5	trace	trace	VERB	VB	VerbForm=Inf	_	_	_	_
6	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
7	deficit	deficit	NOUN	NN	Number=Sing	_	_	_	_
8	of	of	ADP	IN	_	_	_	_	_
9	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
10	mutant	mutant	ADJ	JJ	Degree=Pos	_	_	_	_
11	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
12	to	to	ADP	IN	_	_	_	_	_
13	an	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
14	inefficient	inefficient	ADJ	JJ	Degree=Pos	_	_	_	_
15	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
16	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
17	kappaB	kappaB	PROPN	NNP	Number=Sing	_	_	_	_
18	activation	activation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
19	,	,	PUNCT	,	_	_	_	_	_
20	evidencing	evidence	VERB	VBG	VerbForm=Ger	_	_	_	_
21	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
22	relevant	relevant	ADJ	JJ	Degree=Pos	_	_	_	_
23	role	role	NOUN	NN	Number=Sing	_	_	_	_
24	for	for	ADP	IN	_	_	_	_	_
25	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
26	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
27	kappaB	kappaB	PROPN	NNP	Number=Sing	_	_	_	_
28	in	in	ADP	IN	_	_	_	_	_
29	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
30	regulation	regulation	NOUN	NN	Number=Sing	_	_	_	_
31	of	of	ADP	IN	_	_	_	_	_
32	FasL	Fasl	ADJ	JJ	Degree=Pos	_	_	_	_
33	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
34	in	in	ADP	IN	_	_	_	_	_
35	activated	activated	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
36	T	t	PROPN	NNP	Number=Sing	_	_	_	_
37	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
38	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 756
# text = Furthermore, our results suggest that the induction of FasL versus cytokine gene expression is differentially sensitive to NF-kappaB deprivation.
1	Furthermore	furthermore	ADV	RB	_	_	_	_	SpaceAfter=No
2	,	,	PUNCT	,	_	_	_	_	_
3	our	we	PRON	PRP$	Number=Plur|Person=1|Poss=Yes|PronType=Prs	_	_	_	_
4	results	result	NOUN	NNS	Number=Plur	_	_	_	_
5	suggest	suggest	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
6	that	that	SCONJ	IN	_	_	_	_	_
7	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
8	induction	induction	NOUN	NN	Number=Sing	_	_	_	_
9	of	of	ADP	IN	_	_	_	_	_
10	FasL	Fasl	NOUN	NN	Number=Sing	_	_	_	_
11	versus	versus	ADP	IN	_	_	_	_	_
12	cytokine	cytokine	NOUN	NN	Number=Sing	_	_	_	_
13	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
14	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
15	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
16	differentially	differentially	ADV	RB	_	_	_	_	_
17	sensitive	sensitive	ADJ	JJ	Degree=Pos	_	_	_	_
18	to	to	ADP	IN	_	_	_	_	_
19	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
20	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
21	kappaB	kappaB	PROPN	NNP	Number=Sing	_	_	_	_
22	deprivation	deprivation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
23	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 757
# text = Document 003002274 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	003002274	003002274	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 758
# text = cAMP-dependent regulation of proenkephalin by JunD and JunB: positive and negative effects of AP-1 proteins.
1	cAMP	camp	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
2	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
3	dependent	dependent	ADJ	JJ	Degree=Pos	_	_	_	_
4	regulation	regulation	NOUN	NN	Number=Sing	_	_	_	_
5	of	of	ADP	IN	_	_	_	_	_
6	proenkephalin	proenkephalin	NOUN	NN	Number=Sing	_	_	_	_
7	by	by	ADP	IN	_	_	_	_	_
8	JunD	JunD	PROPN	NNP	Number=Sing	_	_	_	_
9	and	and	CCONJ	CC	_	_	_	_	_
10	JunB	JunB	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
11	:	:	PUNCT	:	_	_	_	_	_
12	positive	positive	ADJ	JJ	Degree=Pos	_	_	_	_
13	and	and	CCONJ	CC	_	_	_	_	_
14	negative	negative	ADJ	JJ	Degree=Pos	_	_	_	_
15	effects	effect	NOUN	NNS	Number=Plur	_	_	_	_
16	of	of	ADP	IN	_	_	_	_	_
17	AP	ap	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
18	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
19	1	1	NUM	CD	NumType=Card	_	_	_	_
20	proteins	protein	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
21	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 759
# text = We demonstrate that JunD, a component of the AP-1 transcription factor complex, activates transcription of the human proenkephalin gene in a fashion that is completely dependent upon the cAMP-dependent protein kinase, protein kinase A.
1	We	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
2	demonstrate	demonstrate	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
3	that	that	SCONJ	IN	_	_	_	_	_
4	JunD	JunD	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
5	,	,	PUNCT	,	_	_	_	_	_
6	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
7	component	component	NOUN	NN	Number=Sing	_	_	_	_
8	of	of	ADP	IN	_	_	_	_	_
9	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
10	AP	ap	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
11	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
12	1	1	NUM	CD	NumType=Card	_	_	_	_
13	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
14	factor	factor	NOUN	NN	Number=Sing	_	_	_	_
15	complex	complex	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
16	,	,	PUNCT	,	_	_	_	_	_
17	activates	activate	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
18	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
19	of	of	ADP	IN	_	_	_	_	_
20	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
21	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
22	proenkephalin	proenkephalin	NOUN	NN	Number=Sing	_	_	_	_
23	gene	gene	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
24	in	in	ADP	IN	_	_	_	_	_
25	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
26	fashion	fashion	NOUN	NN	Number=Sing	_	_	_	_
27	that	that	PRON	WDT	PronType=Rel	_	_	_	_
28	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
29	completely	completely	ADV	RB	_	_	_	_	_
30	dependent	dependent	ADJ	JJ	Degree=Pos	_	_	_	_
31	upon	upon	ADP	IN	_	_	_	_	_
32	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
33	cAMP	camp	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
34	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
35	dependent	dependent	ADJ	JJ	Degree=Pos	_	_	_	_
36	protein	protein	NOUN	NN	Number=Sing	_	_	_	_
37	kinase	kinase	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
38	,	,	PUNCT	,	_	_	_	_	_
39	protein	protein	NOUN	NN	Number=Sing	_	_	_	_
40	kinase	kinase	NOUN	NN	Number=Sing	_	_	_	_
41	A	A	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
42	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 760
# text = Activation of proenkephalin transcription by JunD is dependent upon a previously characterized cAMP-, phorbol ester-, and Ca(2+)-inducible enhancer, and JunD is shown to bind the enhancer as a homodimer.
1	Activation	Activation	NOUN	NN	Number=Sing	_	_	_	_
2	of	of	ADP	IN	_	_	_	_	_
3	proenkephalin	proenkephalin	NOUN	NN	Number=Sing	_	_	_	_
4	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
5	by	by	ADP	IN	_	_	_	_	_
6	JunD	JunD	PROPN	NNP	Number=Sing	_	_	_	_
7	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
8	dependent	dependent	ADJ	JJ	Degree=Pos	_	_	_	_
9	upon	upon	ADP	IN	_	_	_	_	_
10	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
11	previously	previously	ADV	RB	_	_	_	_	_
12	characterized	characterize	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
13	cAMP	camp	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
14	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
15	,	,	PUNCT	,	_	_	_	_	_
16	phorbol	phorbol	NOUN	NN	Number=Sing	_	_	_	_
17	ester	ester	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
18	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
19	,	,	PUNCT	,	_	_	_	_	_
20	and	and	CCONJ	CC	_	_	_	_	_
21	Ca	Ca	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
22	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
23	2	2	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
24	+)	+)	SYM	NFP	_	_	_	_	SpaceAfter=No
25	-	-	SYM	SYM	_	_	_	_	SpaceAfter=No
26	inducible	inducible	ADJ	JJ	Degree=Pos	_	_	_	_
27	enhancer	enhancer	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
28	,	,	PUNCT	,	_	_	_	_	_
29	and	and	CCONJ	CC	_	_	_	_	_
30	JunD	JunD	PROPN	NNP	Number=Sing	_	_	_	_
31	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
32	shown	show	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
33	to	to	PART	TO	_	_	_	_	_
34	bind	bind	VERB	VB	VerbForm=Inf	_	_	_	_
35	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
36	enhancer	enhancer	NOUN	NN	Number=Sing	_	_	_	_
37	as	as	ADP	IN	_	_	_	_	_
38	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
39	homodimer	homodimer	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
40	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 761
# text = Another component of the AP-1 transcription complex, JunB, is shown to inhibit activation mediated by JunD.
1	Another	another	DET	DT	_	_	_	_	_
2	component	component	NOUN	NN	Number=Sing	_	_	_	_
3	of	of	ADP	IN	_	_	_	_	_
4	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
5	AP	ap	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
6	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
7	1	1	NUM	CD	NumType=Card	_	_	_	_
8	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
9	complex	complex	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
10	,	,	PUNCT	,	_	_	_	_	_
11	JunB	JunB	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
12	,	,	PUNCT	,	_	_	_	_	_
13	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
14	shown	show	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
15	to	to	PART	TO	_	_	_	_	_
16	inhibit	inhibit	VERB	VB	VerbForm=Inf	_	_	_	_
17	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
18	mediated	mediate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
19	by	by	ADP	IN	_	_	_	_	_
20	JunD	JunD	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
21	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 762
# text = As a homodimer JunB is unable to bind the enhancer; however in the presence of c-Fos, high-affinity binding is observed.
1	As	as	ADP	IN	_	_	_	_	_
2	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
3	homodimer	homodimer	NOUN	NN	Number=Sing	_	_	_	_
4	JunB	JunB	PROPN	NNP	Number=Sing	_	_	_	_
5	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
6	unable	unable	ADJ	JJ	Degree=Pos	_	_	_	_
7	to	to	PART	TO	_	_	_	_	_
8	bind	bind	VERB	VB	VerbForm=Inf	_	_	_	_
9	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
10	enhancer	enhancer	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
11	;	;	PUNCT	,	_	_	_	_	_
12	however	however	ADV	RB	_	_	_	_	_
13	in	in	ADP	IN	_	_	_	_	_
14	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
15	presence	presence	NOUN	NN	Number=Sing	_	_	_	_
16	of	of	ADP	IN	_	_	_	_	_
17	c	c	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
18	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
19	Fos	Fo	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
20	,	,	PUNCT	,	_	_	_	_	_
21	high	high	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
22	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
23	affinity	affinity	NOUN	NN	Number=Sing	_	_	_	_
24	binding	binding	NOUN	NN	Number=Sing	_	_	_	_
25	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
26	observed	observe	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	SpaceAfter=No
27	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 763
# text = Furthermore, JunD is shown to activate transcription of genes linked to both cAMP and phorbol ester response elements in a protein kinase A-dependent fashion, further blurring the distinction between these response elements.
1	Furthermore	furthermore	ADV	RB	_	_	_	_	SpaceAfter=No
2	,	,	PUNCT	,	_	_	_	_	_
3	JunD	JunD	PROPN	NNP	Number=Sing	_	_	_	_
4	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
5	shown	show	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
6	to	to	PART	TO	_	_	_	_	_
7	activate	activate	VERB	VB	VerbForm=Inf	_	_	_	_
8	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
9	of	of	ADP	IN	_	_	_	_	_
10	genes	gene	NOUN	NNS	Number=Plur	_	_	_	_
11	linked	link	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
12	to	to	ADP	IN	_	_	_	_	_
13	both	both	DET	DT	_	_	_	_	_
14	cAMP	camp	NOUN	NN	Number=Sing	_	_	_	_
15	and	and	CCONJ	CC	_	_	_	_	_
16	phorbol	phorbol	NOUN	NN	Number=Sing	_	_	_	_
17	ester	ester	NOUN	NN	Number=Sing	_	_	_	_
18	response	response	NOUN	NN	Number=Sing	_	_	_	_
19	elements	element	NOUN	NNS	Number=Plur	_	_	_	_
20	in	in	ADP	IN	_	_	_	_	_
21	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
22	protein	protein	NOUN	NN	Number=Sing	_	_	_	_
23	kinase	kinase	NOUN	NN	Number=Sing	_	_	_	_
24	A	a	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
25	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
26	dependent	dependent	ADJ	JJ	Degree=Pos	_	_	_	_
27	fashion	fashion	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
28	,	,	PUNCT	,	_	_	_	_	_
29	further	further	SCONJ	IN	_	_	_	_	_
30	blurring	blurre	VERB	VBG	VerbForm=Ger	_	_	_	_
31	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
32	distinction	distinction	NOUN	NN	Number=Sing	_	_	_	_
33	between	between	ADP	IN	_	_	_	_	_
34	these	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
35	response	response	NOUN	NN	Number=Sing	_	_	_	_
36	elements	element	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
37	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 764
# text = These results demonstrate that the transcriptional activity of an AP-1-related protein is regulated by the cAMP-dependent second-messenger pathway and suggest that JunD and other AP-1-related proteins may play an important role in the regulation of gene expression by cAMP-dependent intracellular signaling pathways.
1	These	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
2	results	result	NOUN	NNS	Number=Plur	_	_	_	_
3	demonstrate	demonstrate	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
4	that	that	SCONJ	IN	_	_	_	_	_
5	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
6	transcriptional	transcriptional	ADJ	JJ	Degree=Pos	_	_	_	_
7	activity	activity	NOUN	NN	Number=Sing	_	_	_	_
8	of	of	ADP	IN	_	_	_	_	_
9	an	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
10	AP	ap	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
11	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
12	1	1	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
13	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
14	related	related	ADJ	JJ	Degree=Pos	_	_	_	_
15	protein	protein	NOUN	NN	Number=Sing	_	_	_	_
16	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
17	regulated	regulate	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
18	by	by	ADP	IN	_	_	_	_	_
19	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
20	cAMP	camp	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
21	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
22	dependent	dependent	ADJ	JJ	Degree=Pos	_	_	_	_
23	second	second	ADJ	JJ	Degree=Pos|NumType=Ord	_	_	_	SpaceAfter=No
24	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
25	messenger	messenger	NOUN	NN	Number=Sing	_	_	_	_
26	pathway	pathway	NOUN	NN	Number=Sing	_	_	_	_
27	and	and	CCONJ	CC	_	_	_	_	_
28	suggest	suggest	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
29	that	that	SCONJ	IN	_	_	_	_	_
30	JunD	JunD	PROPN	NNP	Number=Sing	_	_	_	_
31	and	and	CCONJ	CC	_	_	_	_	_
32	other	other	ADJ	JJ	Degree=Pos	_	_	_	_
33	AP	ap	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
34	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
35	1	1	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
36	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
37	related	relate	ADJ	JJ	Degree=Pos	_	_	_	_
38	proteins	protein	NOUN	NNS	Number=Plur	_	_	_	_
39	may	may	AUX	MD	VerbForm=Fin	_	_	_	_
40	play	play	VERB	VB	VerbForm=Inf	_	_	_	_
41	an	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
42	important	important	ADJ	JJ	Degree=Pos	_	_	_	_
43	role	role	NOUN	NN	Number=Sing	_	_	_	_
44	in	in	ADP	IN	_	_	_	_	_
45	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
46	regulation	regulation	NOUN	NN	Number=Sing	_	_	_	_
47	of	of	ADP	IN	_	_	_	_	_
48	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
49	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
50	by	by	ADP	IN	_	_	_	_	_
51	cAMP	camp	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
52	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
53	dependent	dependent	ADJ	JJ	Degree=Pos	_	_	_	_
54	intracellular	intracellular	ADJ	JJ	Degree=Pos	_	_	_	_
55	signaling	signaling	NOUN	NN	Number=Sing	_	_	_	_
56	pathways	pathway	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
57	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 765
# text = Document 003002277 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	003002277	003002277	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 766
# text = Triggering of the human interleukin-6 gene by interferon-gamma and tumor necrosis factor-alpha in monocytic cells involves cooperation between interferon regulatory factor-1, NF kappa B, and Sp1 transcription factors.
1	Triggering	Triggering	ADP	IN	_	_	_	_	_
2	of	of	ADP	IN	_	_	_	_	_
3	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
4	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
5	interleukin	interleukin	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
6	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
7	6	6	NUM	CD	NumType=Card	_	_	_	_
8	gene	gene	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
9	by	by	ADP	IN	_	_	_	_	_
10	interferon	interferon	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
11	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
12	gamma	gamma	NOUN	NN	Number=Sing	_	_	_	_
13	and	and	CCONJ	CC	_	_	_	_	_
14	tumor	tumor	NOUN	NN	Number=Sing	_	_	_	_
15	necrosis	necrosis	NOUN	NN	Number=Sing	_	_	_	_
16	factor	factor	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
17	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
18	alpha	alpha	NOUN	NN	Number=Sing	_	_	_	_
19	in	in	ADP	IN	_	_	_	_	_
20	monocytic	monocytic	ADJ	JJ	Degree=Pos	_	_	_	_
21	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
22	involves	involve	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
23	cooperation	cooperation	NOUN	NN	Number=Sing	_	_	_	_
24	between	between	ADP	IN	_	_	_	_	_
25	interferon	interferon	ADJ	JJ	Degree=Pos	_	_	_	_
26	regulatory	regulatory	ADJ	JJ	Degree=Pos	_	_	_	_
27	factor	factor	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
28	-1	-1	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
29	,	,	PUNCT	,	_	_	_	_	_
30	NF	NF	PROPN	NNP	Number=Sing	_	_	_	_
31	kappa	kappa	PROPN	NNP	Number=Sing	_	_	_	_
32	B	b	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
33	,	,	PUNCT	,	_	_	_	_	_
34	and	and	CCONJ	CC	_	_	_	_	_
35	Sp1	Sp1	NUM	CD	NumType=Card	_	_	_	_
36	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
37	factors	factor	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
38	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 767
# text = We investigated the molecular basis of the synergistic induction by interferon-gamma (IFN-gamma)/tumor necrosis factor-alpha (TNF-alpha) of human interleukin-6 (IL-6) gene in THP-1 monocytic cells, and compared it with the basis of this induction by lipopolysaccharide (LPS).
1	We	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
2	investigated	investigate	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
3	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
4	molecular	molecular	ADJ	JJ	Degree=Pos	_	_	_	_
5	basis	basis	NOUN	NN	Number=Sing	_	_	_	_
6	of	of	ADP	IN	_	_	_	_	_
7	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
8	synergistic	synergistic	ADJ	JJ	Degree=Pos	_	_	_	_
9	induction	induction	NOUN	NN	Number=Sing	_	_	_	_
10	by	by	ADP	IN	_	_	_	_	_
11	interferon	interferon	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
12	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
13	gamma	gamma	NOUN	NN	Number=Sing	_	_	_	_
14	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
15	IFN	Ifn	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
16	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
17	gamma	gamma	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
18	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
19	/	/	PUNCT	,	_	_	_	_	SpaceAfter=No
20	tumor	tumor	NOUN	NN	Number=Sing	_	_	_	_
21	necrosis	necrosis	NOUN	NN	Number=Sing	_	_	_	_
22	factor	factor	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
23	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
24	alpha	alpha	NOUN	NN	Number=Sing	_	_	_	_
25	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
26	TNF	Tnf	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
27	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
28	alpha	alpha	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
29	)	)	PUNCT	-RRB-	_	_	_	_	_
30	of	of	ADP	IN	_	_	_	_	_
31	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
32	interleukin	interleukin	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
33	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
34	6	6	NUM	CD	NumType=Card	_	_	_	_
35	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
36	IL	Il	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
37	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
38	6	6	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
39	)	)	PUNCT	-RRB-	_	_	_	_	_
40	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
41	in	in	ADP	IN	_	_	_	_	_
42	THP	THP	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
43	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
44	1	1	NUM	CD	NumType=Card	_	_	_	_
45	monocytic	monocytic	ADJ	JJ	Degree=Pos	_	_	_	_
46	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
47	,	,	PUNCT	,	_	_	_	_	_
48	and	and	CCONJ	CC	_	_	_	_	_
49	compared	compare	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
50	it	it	PRON	PRP	Case=Acc|Gender=Neut|Number=Sing|Person=3|PronType=Prs	_	_	_	_
51	with	with	ADP	IN	_	_	_	_	_
52	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
53	basis	basis	NOUN	NN	Number=Sing	_	_	_	_
54	of	of	ADP	IN	_	_	_	_	_
55	this	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
56	induction	induction	NOUN	NN	Number=Sing	_	_	_	_
57	by	by	ADP	IN	_	_	_	_	_
58	lipopolysaccharide	lipopolysaccharide	NOUN	NN	Number=Sing	_	_	_	_
59	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
60	LPS	LPS	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
61	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
62	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 768
# text = Functional studies with IL-6 promoter demonstrated that three regions are the targets of the IFN-gamma and/or TNF-alpha action, whereas only one of these regions seemed to be implicated in LPS activation.
1	Functional	functional	ADJ	JJ	Degree=Pos	_	_	_	_
2	studies	study	NOUN	NNS	Number=Plur	_	_	_	_
3	with	with	ADP	IN	_	_	_	_	_
4	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
5	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
6	6	6	NUM	CD	NumType=Card	_	_	_	_
7	promoter	promoter	NOUN	NN	Number=Sing	_	_	_	_
8	demonstrated	demonstrate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
9	that	that	SCONJ	IN	_	_	_	_	_
10	three	three	NUM	CD	NumType=Card	_	_	_	_
11	regions	region	NOUN	NNS	Number=Plur	_	_	_	_
12	are	be	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
13	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
14	targets	target	NOUN	NNS	Number=Plur	_	_	_	_
15	of	of	ADP	IN	_	_	_	_	_
16	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
17	IFN	Ifn	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
18	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
19	gamma	gamma	NOUN	NN	Number=Sing	_	_	_	_
20	and	and	CCONJ	CC	_	_	_	_	SpaceAfter=No
21	/	/	PUNCT	,	_	_	_	_	SpaceAfter=No
22	or	or	CCONJ	CC	_	_	_	_	_
23	TNF	Tnf	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
24	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
25	alpha	alpha	NOUN	NN	Number=Sing	_	_	_	_
26	action	action	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
27	,	,	PUNCT	,	_	_	_	_	_
28	whereas	whereas	SCONJ	IN	_	_	_	_	_
29	only	only	ADV	RB	_	_	_	_	_
30	one	one	NUM	CD	NumType=Card	_	_	_	_
31	of	of	ADP	IN	_	_	_	_	_
32	these	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
33	regions	region	NOUN	NNS	Number=Plur	_	_	_	_
34	seemed	seem	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
35	to	to	PART	TO	_	_	_	_	_
36	be	be	AUX	VB	VerbForm=Inf	_	_	_	_
37	implicated	implicate	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
38	in	in	ADP	IN	_	_	_	_	_
39	LPS	Lps	ADJ	JJ	Degree=Pos	_	_	_	_
40	activation	activation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
41	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 769
# text = The three regions concerned are: 1) a region between -73 and -36, which is the minimal element inducible by LPS or TNF-alpha; 2) an element located between -181 and -73, which appeared to regulate the response to IFN-gamma and TNF-alpha negatively; and 3) a distal element upstream of -224, which was inducible by IFN-gamma alone.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	three	three	NUM	CD	NumType=Card	_	_	_	_
3	regions	region	NOUN	NNS	Number=Plur	_	_	_	_
4	concerned	concern	ADJ	JJ	Degree=Pos	_	_	_	_
5	are	be	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	SpaceAfter=No
6	:	:	PUNCT	:	_	_	_	_	_
7	1	1	X	LS	_	_	_	_	SpaceAfter=No
8	)	)	PUNCT	-RRB-	_	_	_	_	_
9	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
10	region	region	NOUN	NN	Number=Sing	_	_	_	_
11	between	between	ADP	IN	_	_	_	_	_
12	-	-	SYM	SYM	_	_	_	_	SpaceAfter=No
13	73	73	NUM	CD	NumType=Card	_	_	_	_
14	and	and	CCONJ	CC	_	_	_	_	_
15	-	-	SYM	SYM	_	_	_	_	SpaceAfter=No
16	36	36	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
17	,	,	PUNCT	,	_	_	_	_	_
18	which	which	PRON	WDT	PronType=Rel	_	_	_	_
19	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
20	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
21	minimal	minimal	ADJ	JJ	Degree=Pos	_	_	_	_
22	element	element	NOUN	NN	Number=Sing	_	_	_	_
23	inducible	inducible	ADJ	JJ	Degree=Pos	_	_	_	_
24	by	by	ADP	IN	_	_	_	_	_
25	LPS	Lp	PROPN	NNP	Number=Sing	_	_	_	_
26	or	or	CCONJ	CC	_	_	_	_	_
27	TNF	Tnf	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
28	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
29	alpha	alpha	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
30	;	;	PUNCT	,	_	_	_	_	_
31	2	2	X	LS	_	_	_	_	SpaceAfter=No
32	)	)	PUNCT	-RRB-	_	_	_	_	_
33	an	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
34	element	element	NOUN	NN	Number=Sing	_	_	_	_
35	located	locate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
36	between	between	ADP	IN	_	_	_	_	_
37	-	-	SYM	SYM	_	_	_	_	SpaceAfter=No
38	181	181	NUM	CD	NumType=Card	_	_	_	_
39	and	and	CCONJ	CC	_	_	_	_	_
40	-	-	SYM	SYM	_	_	_	_	SpaceAfter=No
41	73	73	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
42	,	,	PUNCT	,	_	_	_	_	_
43	which	which	PRON	WDT	PronType=Rel	_	_	_	_
44	appeared	appear	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
45	to	to	PART	TO	_	_	_	_	_
46	regulate	regulate	VERB	VB	VerbForm=Inf	_	_	_	_
47	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
48	response	response	NOUN	NN	Number=Sing	_	_	_	_
49	to	to	ADP	IN	_	_	_	_	_
50	IFN	IFN	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
51	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
52	gamma	gamma	NOUN	NN	Number=Sing	_	_	_	_
53	and	and	CCONJ	CC	_	_	_	_	_
54	TNF	Tnf	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
55	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
56	alpha	alpha	NOUN	NN	Number=Sing	_	_	_	_
57	negatively	negatively	ADV	RB	_	_	_	_	SpaceAfter=No
58	;	;	PUNCT	,	_	_	_	_	_
59	and	and	CCONJ	CC	_	_	_	_	_
60	3	3	X	LS	_	_	_	_	SpaceAfter=No
61	)	)	PUNCT	-RRB-	_	_	_	_	_
62	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
63	distal	distal	ADJ	JJ	Degree=Pos	_	_	_	_
64	element	element	NOUN	NN	Number=Sing	_	_	_	_
65	upstream	upstream	NOUN	NN	Number=Sing	_	_	_	_
66	of	of	ADP	IN	_	_	_	_	_
67	-	-	SYM	SYM	_	_	_	_	SpaceAfter=No
68	224	224	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
69	,	,	PUNCT	,	_	_	_	_	_
70	which	which	PRON	WDT	PronType=Rel	_	_	_	_
71	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
72	inducible	inducible	ADJ	JJ	Degree=Pos	_	_	_	_
73	by	by	ADP	IN	_	_	_	_	_
74	IFN	IFN	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
75	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
76	gamma	gamma	NOUN	NN	Number=Sing	_	_	_	_
77	alone	alone	ADV	RB	_	_	_	_	SpaceAfter=No
78	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 770
# text = LPS signaling was found to involve NF kappa B activation by the p50/p65 heterodimers.
1	LPS	Lps	ADJ	JJ	Degree=Pos	_	_	_	_
2	signaling	signaling	NOUN	NN	Number=Sing	_	_	_	_
3	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
4	found	find	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
5	to	to	PART	TO	_	_	_	_	_
6	involve	involve	VERB	VB	VerbForm=Inf	_	_	_	_
7	NF	NF	ADP	RP	_	_	_	_	_
8	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_
9	B	b	NOUN	NN	Number=Sing	_	_	_	_
10	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
11	by	by	ADP	IN	_	_	_	_	_
12	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
13	p50	p50	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
14	/	/	PUNCT	,	_	_	_	_	SpaceAfter=No
15	p65	p65	NOUN	NN	Number=Sing	_	_	_	_
16	heterodimers	heterodimer	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
17	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 771
# text = Synergistic induction of the IL-6 gene by IFN-gamma and TNF-alpha, in monocytic cells, involved cooperation between the IRF-1 and NF kappa B p65 homodimers with concomitant removal of the negative effect of the retinoblastoma control element present in the IL-6 promoter.
1	Synergistic	Synergistic	ADJ	JJ	Degree=Pos	_	_	_	_
2	induction	induction	NOUN	NN	Number=Sing	_	_	_	_
3	of	of	ADP	IN	_	_	_	_	_
4	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
5	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
6	-	-	SYM	SYM	_	_	_	_	SpaceAfter=No
7	6	6	NUM	CD	NumType=Card	_	_	_	_
8	gene	gene	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
9	by	by	ADP	IN	_	_	_	_	_
10	IFN	IFN	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
11	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
12	gamma	gamma	NOUN	NN	Number=Sing	_	_	_	_
13	and	and	CCONJ	CC	_	_	_	_	_
14	TNF	TNF	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
15	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
16	alpha	alpha	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
17	,	,	PUNCT	,	_	_	_	_	_
18	in	in	ADP	IN	_	_	_	_	_
19	monocytic	monocytic	ADJ	JJ	Degree=Pos	_	_	_	_
20	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
21	,	,	PUNCT	,	_	_	_	_	_
22	involved	involve	ADJ	JJ	Degree=Pos	_	_	_	_
23	cooperation	cooperation	NOUN	NN	Number=Sing	_	_	_	_
24	between	between	ADP	IN	_	_	_	_	_
25	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
26	IRF	Irf	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
27	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
28	1	1	NUM	CD	NumType=Card	_	_	_	_
29	and	and	CCONJ	CC	_	_	_	_	_
30	NF	Nf	PROPN	NNP	Number=Sing	_	_	_	_
31	kappa	kappa	PROPN	NNP	Number=Sing	_	_	_	_
32	B	b	PROPN	NNP	Number=Sing	_	_	_	_
33	p65	p65	NUM	CD	NumType=Card	_	_	_	_
34	homodimers	homodimer	NOUN	NNS	Number=Plur	_	_	_	_
35	with	with	ADP	IN	_	_	_	_	_
36	concomitant	concomitant	ADJ	JJ	Degree=Pos	_	_	_	_
37	removal	removal	NOUN	NN	Number=Sing	_	_	_	_
38	of	of	ADP	IN	_	_	_	_	_
39	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
40	negative	negative	ADJ	JJ	Degree=Pos	_	_	_	_
41	effect	effect	NOUN	NN	Number=Sing	_	_	_	_
42	of	of	ADP	IN	_	_	_	_	_
43	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
44	retinoblastoma	retinoblastoma	NOUN	NN	Number=Sing	_	_	_	_
45	control	control	NOUN	NN	Number=Sing	_	_	_	_
46	element	element	NOUN	NN	Number=Sing	_	_	_	_
47	present	present	ADJ	JJ	Degree=Pos	_	_	_	_
48	in	in	ADP	IN	_	_	_	_	_
49	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
50	IL	Il	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
51	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
52	6	6	NUM	CD	NumType=Card	_	_	_	_
53	promoter	promoter	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
54	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 772
# text = This removal occurred by activation of the constitutive Sp1 factor, whose increased binding activity and phosphorylation were mediated by IFN-gamma.
1	This	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
2	removal	removal	NOUN	NN	Number=Sing	_	_	_	_
3	occurred	occur	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
4	by	by	ADP	IN	_	_	_	_	_
5	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
6	of	of	ADP	IN	_	_	_	_	_
7	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
8	constitutive	constitutive	ADJ	JJ	Degree=Pos	_	_	_	_
9	Sp1	sp1	NOUN	NN	Number=Sing	_	_	_	_
10	factor	factor	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
11	,	,	PUNCT	,	_	_	_	_	_
12	whose	whose	PRON	WP$	Poss=Yes|PronType=Int	_	_	_	_
13	increased	increase	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
14	binding	bind	VERB	VBG	VerbForm=Ger	_	_	_	_
15	activity	activity	NOUN	NN	Number=Sing	_	_	_	_
16	and	and	CCONJ	CC	_	_	_	_	_
17	phosphorylation	phosphorylation	NOUN	NN	Number=Sing	_	_	_	_
18	were	be	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
19	mediated	mediate	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
20	by	by	ADP	IN	_	_	_	_	_
21	IFN	IFN	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
22	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
23	gamma	gamma	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
24	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 773
# text = Document 003002279 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	003002279	003002279	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 774
# text = Preassociation of STAT1 with STAT2 and STAT3 in separate signalling complexes prior to cytokine stimulation.
1	Preassociation	Preassociation	NOUN	NN	Number=Sing	_	_	_	_
2	of	of	ADP	IN	_	_	_	_	_
3	STAT1	stat1	NUM	CD	NumType=Card	_	_	_	_
4	with	with	ADP	IN	_	_	_	_	_
5	STAT2	Stat2	NUM	CD	NumType=Card	_	_	_	_
6	and	and	CCONJ	CC	_	_	_	_	_
7	STAT3	STAT3	NUM	CD	NumType=Card	_	_	_	_
8	in	in	ADP	IN	_	_	_	_	_
9	separate	separate	ADJ	JJ	Degree=Pos	_	_	_	_
10	signalling	signalling	NOUN	NN	Number=Sing	_	_	_	_
11	complexes	complex	NOUN	NNS	Number=Plur	_	_	_	_
12	prior	prior	ADJ	JJ	Degree=Pos	_	_	_	_
13	to	to	PART	TO	_	_	_	_	_
14	cytokine	cytokine	VERB	VB	VerbForm=Inf	_	_	_	_
15	stimulation	stimulation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
16	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 775
# text = A variety of cytokines and growth factors act through an induction of gene expression mediated by a family of latent transcription factors called STAT (signal transducers and activators of transcription) proteins.
1	A	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
2	variety	variety	NOUN	NN	Number=Sing	_	_	_	_
3	of	of	ADP	IN	_	_	_	_	_
4	cytokines	cytokine	NOUN	NNS	Number=Plur	_	_	_	_
5	and	and	CCONJ	CC	_	_	_	_	_
6	growth	growth	NOUN	NN	Number=Sing	_	_	_	_
7	factors	factor	NOUN	NNS	Number=Plur	_	_	_	_
8	act	act	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
9	through	through	ADP	IN	_	_	_	_	_
10	an	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
11	induction	induction	NOUN	NN	Number=Sing	_	_	_	_
12	of	of	ADP	IN	_	_	_	_	_
13	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
14	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
15	mediated	mediate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
16	by	by	ADP	IN	_	_	_	_	_
17	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
18	family	family	NOUN	NN	Number=Sing	_	_	_	_
19	of	of	ADP	IN	_	_	_	_	_
20	latent	latent	ADJ	JJ	Degree=Pos	_	_	_	_
21	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
22	factors	factor	NOUN	NNS	Number=Plur	_	_	_	_
23	called	call	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
24	STAT	Stat	NOUN	NN	Number=Sing	_	_	_	_
25	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
26	signal	signal	NOUN	NN	Number=Sing	_	_	_	_
27	transducers	transducer	NOUN	NNS	Number=Plur	_	_	_	_
28	and	and	CCONJ	CC	_	_	_	_	_
29	activators	activator	NOUN	NNS	Number=Plur	_	_	_	_
30	of	of	ADP	IN	_	_	_	_	_
31	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
32	)	)	PUNCT	-RRB-	_	_	_	_	_
33	proteins	protein	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
34	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 776
# text = Ligand-induced tyrosine phosphorylation of the STATs promotes their homodimer and heterodimer formation and subsequent nuclear translocation.
1	Ligand	Ligand	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
2	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
3	induced	induce	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
4	tyrosine	tyrosine	NOUN	NN	Number=Sing	_	_	_	_
5	phosphorylation	phosphorylation	NOUN	NN	Number=Sing	_	_	_	_
6	of	of	ADP	IN	_	_	_	_	_
7	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
8	STATs	STATs	PROPN	NNPS	Number=Plur	_	_	_	_
9	promotes	promote	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
10	their	they	PRON	PRP$	Number=Plur|Person=3|Poss=Yes|PronType=Prs	_	_	_	_
11	homodimer	homodimer	NOUN	NN	Number=Sing	_	_	_	_
12	and	and	CCONJ	CC	_	_	_	_	_
13	heterodimer	heterodimer	NOUN	NN	Number=Sing	_	_	_	_
14	formation	formation	NOUN	NN	Number=Sing	_	_	_	_
15	and	and	CCONJ	CC	_	_	_	_	_
16	subsequent	subsequent	ADJ	JJ	Degree=Pos	_	_	_	_
17	nuclear	nuclear	ADJ	JJ	Degree=Pos	_	_	_	_
18	translocation	translocation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
19	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 777
# text = We demonstrate here that
1	We	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
2	demonstrate	demonstrate	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
3	here	here	ADV	RB	PronType=Dem	_	_	_	_
4	that	that	SCONJ	IN	_	_	_	_	_

# sent_id = 778
# text = STAT protein heterocomplexes exist prior to cytokine treatment.
1	STAT	Stat	ADJ	JJ	Degree=Pos	_	_	_	_
2	protein	protein	NOUN	NN	Number=Sing	_	_	_	_
3	heterocomplexes	heterocomplex	NOUN	NNS	Number=Plur	_	_	_	_
4	exist	exist	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
5	prior	prior	ADJ	JJ	Degree=Pos	_	_	_	_
6	to	to	PART	TO	_	_	_	_	_
7	cytokine	cytokine	VERB	VB	VerbForm=Inf	_	_	_	_
8	treatment	treatment	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
9	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 779
# text = When unstimulated HeLa cells are ruptured in hypotonic buffer without salt or detergent, immunoadsorption of either STAT1 or STAT2 from the resulting cytosol yields coimmunoadsorption of the other STAT protein.
1	When	when	ADV	WRB	PronType=Int	_	_	_	_
2	unstimulated	unstimulate	ADJ	JJ	Degree=Pos	_	_	_	_
3	HeLa	HeLa	PROPN	NNP	Number=Sing	_	_	_	_
4	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
5	are	be	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
6	ruptured	rupture	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
7	in	in	ADP	IN	_	_	_	_	_
8	hypotonic	hypotonic	ADJ	JJ	Degree=Pos	_	_	_	_
9	buffer	buffer	NOUN	NN	Number=Sing	_	_	_	_
10	without	without	ADP	IN	_	_	_	_	_
11	salt	salt	NOUN	NN	Number=Sing	_	_	_	_
12	or	or	CCONJ	CC	_	_	_	_	_
13	detergent	detergent	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
14	,	,	PUNCT	,	_	_	_	_	_
15	immunoadsorption	immunoadsorption	NOUN	NN	Number=Sing	_	_	_	_
16	of	of	ADP	IN	_	_	_	_	_
17	either	either	CCONJ	CC	_	_	_	_	_
18	STAT1	STAT1	NUM	CD	NumType=Card	_	_	_	_
19	or	or	CCONJ	CC	_	_	_	_	_
20	STAT2	STAT2	NUM	CD	NumType=Card	_	_	_	_
21	from	from	ADP	IN	_	_	_	_	_
22	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
23	resulting	result	VERB	VBG	VerbForm=Ger	_	_	_	_
24	cytosol	cytosol	NOUN	NN	Number=Sing	_	_	_	_
25	yields	yield	NOUN	NNS	Number=Plur	_	_	_	_
26	coimmunoadsorption	coimmunoadsorption	NOUN	NN	Number=Sing	_	_	_	_
27	of	of	ADP	IN	_	_	_	_	_
28	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
29	other	other	ADJ	JJ	Degree=Pos	_	_	_	_
30	STAT	STAT	NOUN	NN	Number=Sing	_	_	_	_
31	protein	protein	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
32	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 780
# text = Similarly, STAT1-STAT3 heterocomplexes are coimmunoadsorbed from hypotonic cytosol.
1	Similarly	similarly	ADV	RB	_	_	_	_	SpaceAfter=No
2	,	,	PUNCT	,	_	_	_	_	_
3	STAT1	STAT1	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
4	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
5	STAT3	STAT3	NOUN	NN	Number=Sing	_	_	_	_
6	heterocomplexes	heterocomplex	NOUN	NNS	Number=Plur	_	_	_	_
7	are	be	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
8	coimmunoadsorbed	coimmunoadsor	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
9	from	from	ADP	IN	_	_	_	_	_
10	hypotonic	hypotonic	ADJ	JJ	Degree=Pos	_	_	_	_
11	cytosol	cytosol	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
12	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 781
# text = STAT1 and STAT2 or STAT1 and STAT3 translated in reticulocyte lysate spontaneously form heterocomplexes when the translation lysates are mixed at 0 degrees C. Our data suggest that interferon-alpha /beta-induced tyrosine phosphorylation increases the stability of a preexisting, latent, STAT1-STAT2 signaling complex.
1	STAT1	STAT1	NOUN	NN	Number=Sing	_	_	_	_
2	and	and	CCONJ	CC	_	_	_	_	_
3	STAT2	STAT2	NOUN	NN	Number=Sing	_	_	_	_
4	or	or	CCONJ	CC	_	_	_	_	_
5	STAT1	STAT1	NOUN	NN	Number=Sing	_	_	_	_
6	and	and	CCONJ	CC	_	_	_	_	_
7	STAT3	STAT3	NOUN	NN	Number=Sing	_	_	_	_
8	translated	translate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
9	in	in	ADP	IN	_	_	_	_	_
10	reticulocyte	reticulocyte	NOUN	NN	Number=Sing	_	_	_	_
11	lysate	lysate	NOUN	NN	Number=Sing	_	_	_	_
12	spontaneously	spontaneously	ADV	RB	_	_	_	_	_
13	form	form	ADJ	JJ	Degree=Pos	_	_	_	_
14	heterocomplexes	heterocomplex	NOUN	NNS	Number=Plur	_	_	_	_
15	when	when	ADV	WRB	PronType=Int	_	_	_	_
16	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
17	translation	translation	NOUN	NN	Number=Sing	_	_	_	_
18	lysates	lysate	NOUN	NNS	Number=Plur	_	_	_	_
19	are	be	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
20	mixed	mix	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
21	at	at	ADP	IN	_	_	_	_	_
22	0	0	NUM	CD	NumType=Card	_	_	_	_
23	degrees	degree	NOUN	NNS	Number=Plur	_	_	_	_
24	C	C	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
25	.	.	PUNCT	.	_	_	_	_	_
26	Our	we	PRON	PRP$	Number=Plur|Person=1|Poss=Yes|PronType=Prs	_	_	_	_
27	data	data	NOUN	NN	Number=Sing	_	_	_	_
28	suggest	suggest	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
29	that	that	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
30	interferon	interferon	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
31	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
32	alpha	alpha	NOUN	NN	Number=Sing	_	_	_	_
33	/beta	/beta	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
34	-induced	-induced	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
35	tyrosine	tyrosine	PRON	PRP	_	_	_	_	_
36	phosphorylation	phosphorylation	NOUN	NN	Number=Sing	_	_	_	_
37	increases	increase	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
38	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
39	stability	stability	NOUN	NN	Number=Sing	_	_	_	_
40	of	of	ADP	IN	_	_	_	_	_
41	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
42	preexisting	preexisting	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
43	,	,	PUNCT	,	_	_	_	_	_
44	latent	latent	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
45	,	,	PUNCT	,	_	_	_	_	_
46	STAT1	stat1	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
47	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
48	STAT2	Stat2	NOUN	NN	Number=Sing	_	_	_	_
49	signaling	signaling	NOUN	NN	Number=Sing	_	_	_	_
50	complex	complex	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
51	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 782
# text = Newly translated STAT1 binds in equilibrium fashion to STAT2 and STAT3, but we show that STAT2 and STAT3 exist in separate heterocomplexes with STAT1, consistent with a model in which STAT1 contains a common binding site for other STAT proteins.
1	Newly	newly	ADV	RB	_	_	_	_	_
2	translated	translate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
3	STAT1	stat1	NUM	CD	NumType=Card	_	_	_	_
4	binds	bind	NOUN	NNS	Number=Plur	_	_	_	_
5	in	in	ADP	IN	_	_	_	_	_
6	equilibrium	equilibrium	ADJ	JJ	Degree=Pos	_	_	_	_
7	fashion	fashion	NOUN	NN	Number=Sing	_	_	_	_
8	to	to	ADP	IN	_	_	_	_	_
9	STAT2	Stat2	NUM	CD	NumType=Card	_	_	_	_
10	and	and	CCONJ	CC	_	_	_	_	_
11	STAT3	STAT3	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
12	,	,	PUNCT	,	_	_	_	_	_
13	but	but	CCONJ	CC	_	_	_	_	_
14	we	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
15	show	show	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
16	that	that	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
17	STAT2	STAT2	NOUN	NN	Number=Sing	_	_	_	_
18	and	and	CCONJ	CC	_	_	_	_	_
19	STAT3	STAT3	NOUN	NN	Number=Sing	_	_	_	_
20	exist	exist	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
21	in	in	ADP	IN	_	_	_	_	_
22	separate	separate	ADJ	JJ	Degree=Pos	_	_	_	_
23	heterocomplexes	heterocomplex	NOUN	NNS	Number=Plur	_	_	_	_
24	with	with	ADP	IN	_	_	_	_	_
25	STAT1	stat1	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
26	,	,	PUNCT	,	_	_	_	_	_
27	consistent	consistent	ADJ	JJ	Degree=Pos	_	_	_	_
28	with	with	ADP	IN	_	_	_	_	_
29	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
30	model	model	NOUN	NN	Number=Sing	_	_	_	_
31	in	in	ADP	IN	_	_	_	_	_
32	which	which	PRON	WDT	PronType=Rel	_	_	_	_
33	STAT1	STAT1	PROPN	NNP	Number=Sing	_	_	_	_
34	contains	contain	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
35	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
36	common	common	ADJ	JJ	Degree=Pos	_	_	_	_
37	binding	binding	VERB	VBG	VerbForm=Ger	_	_	_	_
38	site	site	NOUN	NN	Number=Sing	_	_	_	_
39	for	for	ADP	IN	_	_	_	_	_
40	other	other	ADJ	JJ	Degree=Pos	_	_	_	_
41	STAT	Stat	NOUN	NN	Number=Sing	_	_	_	_
42	proteins	protein	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
43	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 783
# text = Document 003002284 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	003002284	003002284	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 784
# text = The involvement of multiple tumor necrosis factor receptor (TNFR)-associated factors in the signaling mechanisms of receptor activator of NF-kappaB, a member of the TNFR superfamily.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	involvement	involvement	NOUN	NN	Number=Sing	_	_	_	_
3	of	of	ADP	IN	_	_	_	_	_
4	multiple	multiple	ADJ	JJ	Degree=Pos	_	_	_	_
5	tumor	tumor	NOUN	NN	Number=Sing	_	_	_	_
6	necrosis	necrosis	NOUN	NN	Number=Sing	_	_	_	_
7	factor	factor	NOUN	NN	Number=Sing	_	_	_	_
8	receptor	receptor	NOUN	NN	Number=Sing	_	_	_	_
9	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
10	TNFR	TNFR	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
11	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
12	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
13	associated	associate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
14	factors	factor	NOUN	NNS	Number=Plur	_	_	_	_
15	in	in	ADP	IN	_	_	_	_	_
16	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
17	signaling	signaling	NOUN	NN	Number=Sing	_	_	_	_
18	mechanisms	mechanism	NOUN	NNS	Number=Plur	_	_	_	_
19	of	of	ADP	IN	_	_	_	_	_
20	receptor	receptor	NOUN	NN	Number=Sing	_	_	_	_
21	activator	activator	NOUN	NN	Number=Sing	_	_	_	_
22	of	of	ADP	IN	_	_	_	_	_
23	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
24	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
25	kappaB	kappaB	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
26	,	,	PUNCT	,	_	_	_	_	_
27	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
28	member	member	NOUN	NN	Number=Sing	_	_	_	_
29	of	of	ADP	IN	_	_	_	_	_
30	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
31	TNFR	TNFR	PROPN	NNP	Number=Sing	_	_	_	_
32	superfamily	superfamily	ADV	RB	_	_	_	_	SpaceAfter=No
33	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 785
# text = Receptor activator of NF-kappaB (RANK) is a recently identified member of the tumor necrosis factor receptor superfamily and is expressed on activated T cells and dendritic cells.
1	Receptor	Receptor	NOUN	NN	Number=Sing	_	_	_	_
2	activator	activator	NOUN	NN	Number=Sing	_	_	_	_
3	of	of	ADP	IN	_	_	_	_	_
4	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
5	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
6	kappaB	kappaB	PROPN	NNP	Number=Sing	_	_	_	_
7	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
8	RANK	rank	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
9	)	)	PUNCT	-RRB-	_	_	_	_	_
10	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
11	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
12	recently	recently	ADV	RB	_	_	_	_	_
13	identified	identify	ADJ	JJ	Degree=Pos	_	_	_	_
14	member	member	NOUN	NN	Number=Sing	_	_	_	_
15	of	of	ADP	IN	_	_	_	_	_
16	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
17	tumor	tumor	NOUN	NN	Number=Sing	_	_	_	_
18	necrosis	necrosis	NOUN	NN	Number=Sing	_	_	_	_
19	factor	factor	NOUN	NN	Number=Sing	_	_	_	_
20	receptor	receptor	NOUN	NN	Number=Sing	_	_	_	_
21	superfamily	superfamily	ADV	RB	_	_	_	_	_
22	and	and	CCONJ	CC	_	_	_	_	_
23	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
24	expressed	express	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
25	on	on	ADP	IN	_	_	_	_	_
26	activated	activate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
27	T	t	PROPN	NNP	Number=Sing	_	_	_	_
28	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
29	and	and	CCONJ	CC	_	_	_	_	_
30	dendritic	dendritic	ADJ	JJ	Degree=Pos	_	_	_	_
31	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
32	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 786
# text = Its cognate ligand (RANKL) plays significant roles in the activation of dendritic cell function and osteoclast differentiation.
1	Its	its	PRON	PRP$	Gender=Neut|Number=Sing|Person=3|Poss=Yes|PronType=Prs	_	_	_	_
2	cognate	cognate	ADJ	JJ	Degree=Pos	_	_	_	_
3	ligand	ligand	NOUN	NN	Number=Sing	_	_	_	_
4	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
5	RANKL	RANKL	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
6	)	)	PUNCT	-RRB-	_	_	_	_	_
7	plays	play	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
8	significant	significant	ADJ	JJ	Degree=Pos	_	_	_	_
9	roles	role	NOUN	NNS	Number=Plur	_	_	_	_
10	in	in	ADP	IN	_	_	_	_	_
11	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
12	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
13	of	of	ADP	IN	_	_	_	_	_
14	dendritic	dendritic	ADJ	JJ	Degree=Pos	_	_	_	_
15	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
16	function	function	NOUN	NN	Number=Sing	_	_	_	_
17	and	and	CCONJ	CC	_	_	_	_	_
18	osteoclast	osteoclast	ADJ	JJ	Degree=Pos	_	_	_	_
19	differentiation	differentiation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
20	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 787
# text = We demonstrate here the interaction of RANK with tumor necrosis factor receptor-associated factors (TRAFs) 1, 2, 3, 5, and 6 both in vitro and in cells.
1	We	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
2	demonstrate	demonstrate	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
3	here	here	ADV	RB	PronType=Dem	_	_	_	_
4	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
5	interaction	interaction	NOUN	NN	Number=Sing	_	_	_	_
6	of	of	ADP	IN	_	_	_	_	_
7	RANK	rank	PROPN	NNP	Number=Sing	_	_	_	_
8	with	with	ADP	IN	_	_	_	_	_
9	tumor	tumor	NOUN	NN	Number=Sing	_	_	_	_
10	necrosis	necrosis	NOUN	NN	Number=Sing	_	_	_	_
11	factor	factor	NOUN	NN	Number=Sing	_	_	_	_
12	receptor	receptor	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
13	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
14	associated	associate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
15	factors	factor	NOUN	NNS	Number=Plur	_	_	_	_
16	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
17	TRAFs	Trafs	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
18	)	)	PUNCT	-RRB-	_	_	_	_	_
19	1	1	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
20	,	,	PUNCT	,	_	_	_	_	_
21	2	2	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
22	,	,	PUNCT	,	_	_	_	_	_
23	3	3	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
24	,	,	PUNCT	,	_	_	_	_	_
25	5	5	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
26	,	,	PUNCT	,	_	_	_	_	_
27	and	and	CCONJ	CC	_	_	_	_	_
28	6	6	NUM	CD	NumType=Card	_	_	_	_
29	both	both	CCONJ	CC	_	_	_	_	_
30	in	in	ADP	IN	_	_	_	_	_
31	vitro	vitro	NOUN	NN	Number=Sing	_	_	_	_
32	and	and	CCONJ	CC	_	_	_	_	_
33	in	in	ADP	IN	_	_	_	_	_
34	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
35	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 788
# text = Mapping of the structural requirements for TRAF/RANK interaction revealed multiple TRAF binding sites clustered in two distinct domains in the RANK cytoplasmic tail.
1	Mapping	mapping	NOUN	NN	Number=Sing	_	_	_	_
2	of	of	ADP	IN	_	_	_	_	_
3	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
4	structural	structural	ADJ	JJ	Degree=Pos	_	_	_	_
5	requirements	requirement	NOUN	NNS	Number=Plur	_	_	_	_
6	for	for	ADP	IN	_	_	_	_	_
7	TRAF	TRAF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
8	/	/	PUNCT	,	_	_	_	_	SpaceAfter=No
9	RANK	rank	PROPN	NNP	Number=Sing	_	_	_	_
10	interaction	interaction	NOUN	NN	Number=Sing	_	_	_	_
11	revealed	reveal	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
12	multiple	multiple	ADJ	JJ	Degree=Pos	_	_	_	_
13	TRAF	Traf	SCONJ	IN	_	_	_	_	_
14	binding	bind	VERB	VBG	VerbForm=Ger	_	_	_	_
15	sites	site	NOUN	NNS	Number=Plur	_	_	_	_
16	clustered	cluster	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
17	in	in	ADP	IN	_	_	_	_	_
18	two	two	NUM	CD	NumType=Card	_	_	_	_
19	distinct	distinct	ADJ	JJ	Degree=Pos	_	_	_	_
20	domains	domains	NOUN	NNS	Number=Plur	_	_	_	_
21	in	in	ADP	IN	_	_	_	_	_
22	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
23	RANK	rank	PROPN	NNP	Number=Sing	_	_	_	_
24	cytoplasmic	cytoplasmic	ADJ	JJ	Degree=Pos	_	_	_	_
25	tail	tail	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
26	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 789
# text = These TRAF binding domains were shown to be functionally important for the RANK-dependent induction of NF-kappaB and c-Jun NH2-terminal kinase activities.
1	These	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
2	TRAF	Traf	NOUN	NN	Number=Sing	_	_	_	_
3	binding	binding	VERB	VBG	VerbForm=Ger	_	_	_	_
4	domains	domain	NOUN	NNS	Number=Plur	_	_	_	_
5	were	be	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
6	shown	show	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
7	to	to	PART	TO	_	_	_	_	_
8	be	be	AUX	VB	VerbForm=Inf	_	_	_	_
9	functionally	functionally	ADV	RB	_	_	_	_	_
10	important	important	ADJ	JJ	Degree=Pos	_	_	_	_
11	for	for	ADP	IN	_	_	_	_	_
12	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
13	RANK	Rank	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
14	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
15	dependent	dependent	ADJ	JJ	Degree=Pos	_	_	_	_
16	induction	induction	NOUN	NN	Number=Sing	_	_	_	_
17	of	of	ADP	IN	_	_	_	_	_
18	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
19	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
20	kappaB	kappaB	PROPN	NNP	Number=Sing	_	_	_	_
21	and	and	CCONJ	CC	_	_	_	_	_
22	c	care	NOUN	NN	Abbr=Yes|Number=Sing	_	_	_	SpaceAfter=No
23	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
24	Jun	Jun	PROPN	NNP	Number=Sing	_	_	_	_
25	NH2	NH2	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
26	-terminal	-terminal	ADJ	JJ	Degree=Pos	_	_	_	_
27	kinase	kinase	NOUN	NN	Number=Sing	_	_	_	_
28	activities	activity	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
29	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 790
# text = Site-directed mutagenesis demonstrated that these TRAF binding sites exhibited selective binding for different TRAF proteins.
1	Site	site	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
2	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
3	directed	direct	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
4	mutagenesis	mutagenesis	PRON	PRP$	Gender=Masc|Number=Sing|Person=3|Poss=Yes|PronType=Prs	_	_	_	_
5	demonstrated	demonstrate	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
6	that	that	SCONJ	IN	_	_	_	_	_
7	these	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
8	TRAF	Traf	NOUN	NN	Number=Sing	_	_	_	_
9	binding	binding	VERB	VBG	VerbForm=Ger	_	_	_	_
10	sites	site	NOUN	NNS	Number=Plur	_	_	_	_
11	exhibited	exhibite	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
12	selective	selective	ADJ	JJ	Degree=Pos	_	_	_	_
13	binding	binding	VERB	VBG	VerbForm=Ger	_	_	_	_
14	for	for	ADP	IN	_	_	_	_	_
15	different	different	ADJ	JJ	Degree=Pos	_	_	_	_
16	TRAF	TRAF	PROPN	NNP	Number=Sing	_	_	_	_
17	proteins	protein	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
18	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 791
# text = In particular, TRAF6 interacted with membrane-proximal determinants distinct from those binding TRAFs 1, 2, 3, and 5.
1	In	in	ADP	IN	_	_	_	_	_
2	particular	particular	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
3	,	,	PUNCT	,	_	_	_	_	_
4	TRAF6	Traf6	PROPN	NNP	Number=Sing	_	_	_	_
5	interacted	interact	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
6	with	with	ADP	IN	_	_	_	_	_
7	membrane	membrane	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
8	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
9	proximal	proximal	ADJ	JJ	Degree=Pos	_	_	_	_
10	determinants	determinant	NOUN	NNS	Number=Plur	_	_	_	_
11	distinct	distinct	ADJ	JJ	Degree=Pos	_	_	_	_
12	from	from	ADP	IN	_	_	_	_	_
13	those	those	PRON	DT	Number=Plur|PronType=Dem	_	_	_	_
14	binding	bind	VERB	VBG	VerbForm=Ger	_	_	_	_
15	TRAFs	TRAFs	ADV	RB	_	_	_	_	_
16	1	1	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
17	,	,	PUNCT	,	_	_	_	_	_
18	2	2	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
19	,	,	PUNCT	,	_	_	_	_	_
20	3	3	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
21	,	,	PUNCT	,	_	_	_	_	_
22	and	and	CCONJ	CC	_	_	_	_	_
23	5	5	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
24	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 792
# text = When this membrane-proximal TRAF6 interaction domain was deleted, RANK-mediated NF-kappaB signaling was completely inhibited while c-Jun NH2-terminal kinase activation was partially inhibited.
1	When	when	ADV	WRB	PronType=Int	_	_	_	_
2	this	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
3	membrane	membrane	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
4	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
5	proximal	proximal	ADJ	JJ	Degree=Pos	_	_	_	_
6	TRAF6	TRAF6	NUM	CD	NumType=Card	_	_	_	_
7	interaction	interaction	NOUN	NN	Number=Sing	_	_	_	_
8	domain	domain	NOUN	NN	Number=Sing	_	_	_	_
9	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
10	deleted	delete	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	SpaceAfter=No
11	,	,	PUNCT	,	_	_	_	_	_
12	RANK	Rank	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
13	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
14	mediated	mediate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
15	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
16	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
17	kappaB	kappaB	PROPN	NNP	Number=Sing	_	_	_	_
18	signaling	signaling	NOUN	NN	Number=Sing	_	_	_	_
19	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
20	completely	completely	ADV	RB	_	_	_	_	_
21	inhibited	inhibit	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
22	while	while	SCONJ	IN	_	_	_	_	_
23	c-	c-	SYM	NFP	_	_	_	_	SpaceAfter=No
24	Jun	Jun	PROPN	NNP	Number=Sing	_	_	_	_
25	NH2	NH2	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
26	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
27	terminal	terminal	ADJ	JJ	Degree=Pos	_	_	_	_
28	kinase	kinase	NOUN	NN	Number=Sing	_	_	_	_
29	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
30	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
31	partially	partially	ADV	RB	_	_	_	_	_
32	inhibited	inhibit	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	SpaceAfter=No
33	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 793
# text = An NH2-terminal truncation mutant of TRAF6 inhibited RANKL-mediated NF-kappaB activation, but failed to affect constitutive signaling induced by receptor overexpression, revealing a selective role for TRAF6 in ligand-induced activation events.
1	An	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
2	NH2	Nh2	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
3	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
4	terminal	terminal	ADJ	JJ	Degree=Pos	_	_	_	_
5	truncation	truncation	NOUN	NN	Number=Sing	_	_	_	_
6	mutant	mutant	NOUN	NN	Number=Sing	_	_	_	_
7	of	of	ADP	IN	_	_	_	_	_
8	TRAF6	TRAF6	NUM	CD	NumType=Card	_	_	_	_
9	inhibited	inhibit	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
10	RANKL	Rankl	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
11	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
12	mediated	mediate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
13	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
14	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
15	kappaB	kappaB	PROPN	NNP	Number=Sing	_	_	_	_
16	activation	activation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
17	,	,	PUNCT	,	_	_	_	_	_
18	but	but	CCONJ	CC	_	_	_	_	_
19	failed	fail	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
20	to	to	PART	TO	_	_	_	_	_
21	affect	affect	VERB	VB	VerbForm=Inf	_	_	_	_
22	constitutive	constitutive	ADJ	JJ	Degree=Pos	_	_	_	_
23	signaling	signaling	NOUN	NN	Number=Sing	_	_	_	_
24	induced	induce	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
25	by	by	ADP	IN	_	_	_	_	_
26	receptor	receptor	NOUN	NN	Number=Sing	_	_	_	_
27	overexpression	overexpression	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
28	,	,	PUNCT	,	_	_	_	_	_
29	revealing	reveal	VERB	VBG	VerbForm=Ger	_	_	_	_
30	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
31	selective	selective	ADJ	JJ	Degree=Pos	_	_	_	_
32	role	role	NOUN	NN	Number=Sing	_	_	_	_
33	for	for	ADP	IN	_	_	_	_	_
34	TRAF6	TRAF6	NUM	CD	NumType=Card	_	_	_	_
35	in	in	ADP	IN	_	_	_	_	_
36	ligand	ligand	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
37	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
38	induced	induce	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
39	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
40	events	event	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
41	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 794
# text = Document 003002287 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	003002287	003002287	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 795
# text = The AP-1 site at -150 bp, but not the NF-kappa B site, is likely to represent the major target of protein kinase C in the interleukin 2 promoter.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	AP	ap	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
3	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
4	1	1	NUM	CD	NumType=Card	_	_	_	_
5	site	site	NOUN	NN	Number=Sing	_	_	_	_
6	at	at	ADP	IN	_	_	_	_	_
7	-	-	SYM	SYM	_	_	_	_	SpaceAfter=No
8	150	150	NUM	CD	NumType=Card	_	_	_	_
9	bp	bp	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
10	,	,	PUNCT	,	_	_	_	_	_
11	but	but	CCONJ	CC	_	_	_	_	_
12	not	not	ADV	RB	_	_	_	_	_
13	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
14	NF	NF	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
15	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
16	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_
17	B	b	NOUN	NN	Number=Sing	_	_	_	_
18	site	site	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
19	,	,	PUNCT	,	_	_	_	_	_
20	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
21	likely	likely	ADJ	JJ	Degree=Pos	_	_	_	_
22	to	to	PART	TO	_	_	_	_	_
23	represent	represent	VERB	VB	VerbForm=Inf	_	_	_	_
24	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
25	major	major	ADJ	JJ	Degree=Pos	_	_	_	_
26	target	target	NOUN	NN	Number=Sing	_	_	_	_
27	of	of	ADP	IN	_	_	_	_	_
28	protein	protein	NOUN	NN	Number=Sing	_	_	_	_
29	kinase	kinase	NOUN	NN	Number=Sing	_	_	_	_
30	C	c	NOUN	NN	Number=Sing	_	_	_	_
31	in	in	ADP	IN	_	_	_	_	_
32	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
33	interleukin	interleukin	NOUN	NN	Number=Sing	_	_	_	_
34	2	2	NUM	CD	NumType=Card	_	_	_	_
35	promoter	promoter	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
36	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 796
# text = Stimulation of T cells with antigen results in activation of several kinases, including protein kinase C (PKC), that may mediate the later induction of activation-related genes.
1	Stimulation	Stimulation	NOUN	NN	Number=Sing	_	_	_	_
2	of	of	ADP	IN	_	_	_	_	_
3	T	t	PROPN	NNP	Number=Sing	_	_	_	_
4	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
5	with	with	ADP	IN	_	_	_	_	_
6	antigen	antigen	ADJ	JJ	Degree=Pos	_	_	_	_
7	results	result	NOUN	NNS	Number=Plur	_	_	_	_
8	in	in	ADP	IN	_	_	_	_	_
9	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
10	of	of	ADP	IN	_	_	_	_	_
11	several	several	ADJ	JJ	Degree=Pos	_	_	_	_
12	kinases	kinase	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
13	,	,	PUNCT	,	_	_	_	_	_
14	including	include	VERB	VBG	VerbForm=Ger	_	_	_	_
15	protein	protein	NOUN	NN	Number=Sing	_	_	_	_
16	kinase	kinase	NOUN	NN	Number=Sing	_	_	_	_
17	C	C	PROPN	NNP	Number=Sing	_	_	_	_
18	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
19	PKC	PKC	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
20	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
21	,	,	PUNCT	,	_	_	_	_	_
22	that	that	PRON	DT	Number=Sing|PronType=Dem	_	_	_	_
23	may	may	AUX	MD	VerbForm=Fin	_	_	_	_
24	mediate	mediate	VERB	VB	VerbForm=Inf	_	_	_	_
25	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
26	later	later	ADJ	JJR	Degree=Cmp	_	_	_	_
27	induction	induction	NOUN	NN	Number=Sing	_	_	_	_
28	of	of	ADP	IN	_	_	_	_	_
29	activation	activation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
30	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
31	related	related	ADJ	JJ	Degree=Pos	_	_	_	_
32	genes	gene	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
33	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 797
# text = We have examined the potential role of PKC in induction of the interleukin 2 (IL-2) gene in T cells stimulated through the T cell receptor/CD3 complex.
1	We	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
2	have	have	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
3	examined	examine	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
4	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
5	potential	potential	ADJ	JJ	Degree=Pos	_	_	_	_
6	role	role	NOUN	NN	Number=Sing	_	_	_	_
7	of	of	ADP	IN	_	_	_	_	_
8	PKC	PKC	PROPN	NNP	Number=Sing	_	_	_	_
9	in	in	ADP	IN	_	_	_	_	_
10	induction	induction	NOUN	NN	Number=Sing	_	_	_	_
11	of	of	ADP	IN	_	_	_	_	_
12	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
13	interleukin	interleukin	NOUN	NN	Number=Sing	_	_	_	_
14	2	2	NUM	CD	NumType=Card	_	_	_	_
15	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
16	IL	Il	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
17	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
18	2	2	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
19	)	)	PUNCT	-RRB-	_	_	_	_	_
20	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
21	in	in	ADP	IN	_	_	_	_	_
22	T	t	PROPN	NNP	Number=Sing	_	_	_	_
23	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
24	stimulated	stimulate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
25	through	through	ADP	IN	_	_	_	_	_
26	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
27	T	T	PROPN	NNP	Number=Sing	_	_	_	_
28	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
29	receptor/CD3	receptor/CD3	NUM	CD	NumType=Card	_	_	_	_
30	complex	complex	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
31	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 798
# text = We have previously shown that prolonged treatment of the untransformed T cell clone Ar-5 with phorbol esters results in downmodulation of the alpha and beta isozymes of PKC, and abrogates induction of IL-2 mRNA and protein.
1	We	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
2	have	have	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
3	previously	previously	ADV	RB	_	_	_	_	_
4	shown	show	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
5	that	that	SCONJ	IN	_	_	_	_	_
6	prolonged	prolonge	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
7	treatment	treatment	NOUN	NN	Number=Sing	_	_	_	_
8	of	of	ADP	IN	_	_	_	_	_
9	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
10	untransformed	untransformed	ADJ	JJ	Degree=Pos	_	_	_	_
11	T	T	PROPN	NNP	Number=Sing	_	_	_	_
12	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
13	clone	clone	NOUN	NN	Number=Sing	_	_	_	_
14	Ar	be	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
15	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
16	5	5	NUM	CD	NumType=Card	_	_	_	_
17	with	with	ADP	IN	_	_	_	_	_
18	phorbol	phorbol	NOUN	NN	Number=Sing	_	_	_	_
19	esters	ester	NOUN	NNS	Number=Plur	_	_	_	_
20	results	result	NOUN	NNS	Number=Plur	_	_	_	_
21	in	in	ADP	IN	_	_	_	_	_
22	downmodulation	downmodulation	NOUN	NN	Number=Sing	_	_	_	_
23	of	of	ADP	IN	_	_	_	_	_
24	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
25	alpha	alpha	NOUN	NN	Number=Sing	_	_	_	_
26	and	and	CCONJ	CC	_	_	_	_	_
27	beta	beta	NOUN	NN	Number=Sing	_	_	_	_
28	isozymes	isozyme	NOUN	NNS	Number=Plur	_	_	_	_
29	of	of	ADP	IN	_	_	_	_	_
30	PKC	PKC	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
31	,	,	PUNCT	,	_	_	_	_	_
32	and	and	CCONJ	CC	_	_	_	_	_
33	abrogates	abrogate	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
34	induction	induction	NOUN	NN	Number=Sing	_	_	_	_
35	of	of	ADP	IN	_	_	_	_	_
36	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
37	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
38	2	2	NUM	CD	NumType=Card	_	_	_	_
39	mRNA	mRNa	NOUN	NN	Number=Sing	_	_	_	_
40	and	and	CCONJ	CC	_	_	_	_	_
41	protein	protein	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
42	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 799
# text = Here we show that phorbol ester treatment also abolishes induction of chloramphenicol acetyltransferase activity in Ar-5 cells transfected with a plasmid containing the IL-2 promoter linked to this reporter gene.
1	Here	here	ADV	RB	PronType=Dem	_	_	_	_
2	we	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
3	show	show	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
4	that	that	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
5	phorbol	phorbol	NOUN	NN	Number=Sing	_	_	_	_
6	ester	ester	NOUN	NN	Number=Sing	_	_	_	_
7	treatment	treatment	NOUN	NN	Number=Sing	_	_	_	_
8	also	also	ADV	RB	_	_	_	_	_
9	abolishes	abolish	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
10	induction	induction	NOUN	NN	Number=Sing	_	_	_	_
11	of	of	ADP	IN	_	_	_	_	_
12	chloramphenicol	chloramphenicol	NOUN	NN	Number=Sing	_	_	_	_
13	acetyltransferase	acetyltransferase	NOUN	NN	Number=Sing	_	_	_	_
14	activity	activity	NOUN	NN	Number=Sing	_	_	_	_
15	in	in	ADP	IN	_	_	_	_	_
16	Ar	ar	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
17	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
18	5	5	NUM	CD	NumType=Card	_	_	_	_
19	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
20	transfected	transfect	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
21	with	with	ADP	IN	_	_	_	_	_
22	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
23	plasmid	plasmid	NOUN	NN	Number=Sing	_	_	_	_
24	containing	contain	VERB	VBG	VerbForm=Ger	_	_	_	_
25	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
26	IL	Il	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
27	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
28	2	2	NUM	CD	NumType=Card	_	_	_	_
29	promoter	promoter	NOUN	NN	Number=Sing	_	_	_	_
30	linked	link	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
31	to	to	ADP	IN	_	_	_	_	_
32	this	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
33	reporter	reporter	NOUN	NN	Number=Sing	_	_	_	_
34	gene	gene	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
35	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 800
# text = The IL-2 promoter contains binding sites for nuclear factors including NFAT-1, Oct, NF-kappa B, and AP-1, which are all potentially sensitive to activation of PKC.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	IL	Il	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
3	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
4	2	2	NUM	CD	NumType=Card	_	_	_	_
5	promoter	promoter	NOUN	NN	Number=Sing	_	_	_	_
6	contains	contain	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
7	binding	bind	VERB	VBG	VerbForm=Ger	_	_	_	_
8	sites	site	NOUN	NNS	Number=Plur	_	_	_	_
9	for	for	ADP	IN	_	_	_	_	_
10	nuclear	nuclear	ADJ	JJ	Degree=Pos	_	_	_	_
11	factors	factor	NOUN	NNS	Number=Plur	_	_	_	_
12	including	include	VERB	VBG	VerbForm=Ger	_	_	_	_
13	NFAT	Nfat	ADV	RB	_	_	_	_	SpaceAfter=No
14	-1	-1	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
15	,	,	PUNCT	,	_	_	_	_	_
16	Oct	Oct	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
17	,	,	PUNCT	,	_	_	_	_	_
18	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
19	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
20	kappa	kappa	PROPN	NNP	Number=Sing	_	_	_	_
21	B	b	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
22	,	,	PUNCT	,	_	_	_	_	_
23	and	and	CCONJ	CC	_	_	_	_	_
24	AP	ap	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
25	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
26	1	1	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
27	,	,	PUNCT	,	_	_	_	_	_
28	which	which	PRON	WDT	PronType=Rel	_	_	_	_
29	are	be	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
30	all	all	ADV	RB	_	_	_	_	_
31	potentially	potentially	ADV	RB	_	_	_	_	_
32	sensitive	sensitive	ADJ	JJ	Degree=Pos	_	_	_	_
33	to	to	ADP	IN	_	_	_	_	_
34	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
35	of	of	ADP	IN	_	_	_	_	_
36	PKC	PKC	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
37	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 801
# text = We show that induction of a trimer of the NFAT and Oct sites is not sensitive to phorbol ester treatment, and that mutations in the NF-kappa B site have no effect on inducibility of the IL-2 promoter.
1	We	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
2	show	show	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
3	that	that	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
4	induction	induction	NOUN	NN	Number=Sing	_	_	_	_
5	of	of	ADP	IN	_	_	_	_	_
6	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
7	trimer	trimer	NOUN	NN	Number=Sing	_	_	_	_
8	of	of	ADP	IN	_	_	_	_	_
9	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
10	NFAT	NFAT	PROPN	NNP	Number=Sing	_	_	_	_
11	and	and	CCONJ	CC	_	_	_	_	_
12	Oct	Oct	PROPN	NNP	Number=Sing	_	_	_	_
13	sites	site	NOUN	NNS	Number=Plur	_	_	_	_
14	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
15	not	not	PART	RB	_	_	_	_	_
16	sensitive	sensitive	ADJ	JJ	Degree=Pos	_	_	_	_
17	to	to	PART	TO	_	_	_	_	_
18	phorbol	phorbol	VERB	VB	VerbForm=Inf	_	_	_	_
19	ester	ester	NOUN	NN	Number=Sing	_	_	_	_
20	treatment	treatment	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
21	,	,	PUNCT	,	_	_	_	_	_
22	and	and	CCONJ	CC	_	_	_	_	_
23	that	that	SCONJ	IN	_	_	_	_	_
24	mutations	mutation	NOUN	NNS	Number=Plur	_	_	_	_
25	in	in	ADP	IN	_	_	_	_	_
26	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
27	NF	Nf	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
28	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
29	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_
30	B	b	NOUN	NN	Number=Sing	_	_	_	_
31	site	site	NOUN	NN	Number=Sing	_	_	_	_
32	have	have	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
33	no	no	DET	DT	_	_	_	_	_
34	effect	effect	NOUN	NN	Number=Sing	_	_	_	_
35	on	on	ADP	IN	_	_	_	_	_
36	inducibility	inducibility	NOUN	NN	Number=Sing	_	_	_	_
37	of	of	ADP	IN	_	_	_	_	_
38	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
39	IL	Il	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
40	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
41	2	2	NUM	CD	NumType=Card	_	_	_	_
42	promoter	promoter	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
43	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 802
# text = In contrast, mutations in the AP-1 site located at -150 bp almost completely abrogate induction of the IL-2 promoter, and appearance of an inducible nuclear factor binding to this site is sensitive to PKC depletion.
1	In	in	ADP	IN	_	_	_	_	_
2	contrast	contrast	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
3	,	,	PUNCT	,	_	_	_	_	_
4	mutations	mutation	NOUN	NNS	Number=Plur	_	_	_	_
5	in	in	ADP	IN	_	_	_	_	_
6	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
7	AP	ap	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
8	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
9	1	1	NUM	CD	NumType=Card	_	_	_	_
10	site	site	NOUN	NN	Number=Sing	_	_	_	_
11	located	locate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
12	at	at	ADP	IN	_	_	_	_	_
13	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
14	150	150	NUM	CD	NumType=Card	_	_	_	_
15	bp	bp	NOUN	NN	Number=Sing	_	_	_	_
16	almost	almost	ADV	RB	_	_	_	_	_
17	completely	completely	ADV	RB	_	_	_	_	_
18	abrogate	abrogate	ADJ	JJ	Degree=Pos	_	_	_	_
19	induction	induction	NOUN	NN	Number=Sing	_	_	_	_
20	of	of	ADP	IN	_	_	_	_	_
21	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
22	IL	Il	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
23	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
24	2	2	NUM	CD	NumType=Card	_	_	_	_
25	promoter	promoter	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
26	,	,	PUNCT	,	_	_	_	_	_
27	and	and	CCONJ	CC	_	_	_	_	_
28	appearance	appearance	NOUN	NN	Number=Sing	_	_	_	_
29	of	of	ADP	IN	_	_	_	_	_
30	an	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
31	inducible	inducible	ADJ	JJ	Degree=Pos	_	_	_	_
32	nuclear	nuclear	ADJ	JJ	Degree=Pos	_	_	_	_
33	factor	factor	NOUN	NN	Number=Sing	_	_	_	_
34	binding	bind	VERB	VBG	VerbForm=Ger	_	_	_	_
35	to	to	ADP	IN	_	_	_	_	_
36	this	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
37	site	site	NOUN	NN	Number=Sing	_	_	_	_
38	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
39	sensitive	sensitive	ADJ	JJ	Degree=Pos	_	_	_	_
40	to	to	ADP	IN	_	_	_	_	_
41	PKC	PKC	PROPN	NNP	Number=Sing	_	_	_	_
42	depletion	depletion	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
43	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 803
# text = Moreover, cotransfections with c-fos and c-jun expression plasmids markedly enhance induction of the IL-2 promoter in minimally stimulated T cells.
1	Moreover	moreover	ADV	RB	_	_	_	_	SpaceAfter=No
2	,	,	PUNCT	,	_	_	_	_	_
3	cotransfections	cotransfection	NOUN	NNS	Number=Plur	_	_	_	_
4	with	with	ADP	IN	_	_	_	_	_
5	c-	c-	SYM	NFP	_	_	_	_	SpaceAfter=No
6	fos	fo	NOUN	NNS	Number=Plur	_	_	_	_
7	and	and	CCONJ	CC	_	_	_	_	_
8	c-	c-	SYM	NFP	_	_	_	_	SpaceAfter=No
9	jun	jun	ADJ	JJ	Degree=Pos	_	_	_	_
10	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
11	plasmids	plasmid	NOUN	NNS	Number=Plur	_	_	_	_
12	markedly	markedly	ADV	RB	_	_	_	_	_
13	enhance	enhance	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
14	induction	induction	NOUN	NN	Number=Sing	_	_	_	_
15	of	of	ADP	IN	_	_	_	_	_
16	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
17	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
18	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
19	2	2	NUM	CD	NumType=Card	_	_	_	_
20	promoter	promoter	NOUN	NN	Number=Sing	_	_	_	_
21	in	in	ADP	IN	_	_	_	_	_
22	minimally	minimally	ADV	RB	_	_	_	_	_
23	stimulated	stimulate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
24	T	t	PROPN	NNP	Number=Sing	_	_	_	_
25	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
26	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 804
# text = Our results indicate that the AP-1 site at -150 bp represents a major, if not the only, site of PKC responsiveness in the IL-2 promoter.
1	Our	we	PRON	PRP$	Number=Plur|Person=1|Poss=Yes|PronType=Prs	_	_	_	_
2	results	result	NOUN	NNS	Number=Plur	_	_	_	_
3	indicate	indicate	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
4	that	that	SCONJ	IN	_	_	_	_	_
5	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
6	AP	ap	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
7	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
8	1	1	NUM	CD	NumType=Card	_	_	_	_
9	site	site	NOUN	NN	Number=Sing	_	_	_	_
10	at	at	ADP	IN	_	_	_	_	_
11	-	-	SYM	SYM	_	_	_	_	SpaceAfter=No
12	150	150	NUM	CD	NumType=Card	_	_	_	_
13	bp	bp	NOUN	NN	Number=Sing	_	_	_	_
14	represents	represent	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
15	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
16	major	major	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
17	,	,	PUNCT	,	_	_	_	_	_
18	if	if	SCONJ	IN	_	_	_	_	_
19	not	not	ADV	RB	_	_	_	_	_
20	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
21	only	only	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
22	,	,	PUNCT	,	_	_	_	_	_
23	site	site	NOUN	NN	Number=Sing	_	_	_	_
24	of	of	ADP	IN	_	_	_	_	_
25	PKC	Pkc	NOUN	NN	Number=Sing	_	_	_	_
26	responsiveness	responsiveness	NOUN	NN	Number=Sing	_	_	_	_
27	in	in	ADP	IN	_	_	_	_	_
28	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
29	IL	Il	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
30	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
31	2	2	NUM	CD	NumType=Card	_	_	_	_
32	promoter	promoter	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
33	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 805
# text = Document 003002289 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	003002289	003002289	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 806
# text = Lipopolysaccharide induction of the tumor necrosis factor-alpha promoter in human monocytic cells.
1	Lipopolysaccharide	Lipopolysaccharide	VERB	VB	Mood=Imp|VerbForm=Fin	_	_	_	_
2	induction	induction	NOUN	NN	Number=Sing	_	_	_	_
3	of	of	ADP	IN	_	_	_	_	_
4	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
5	tumor	tumor	NOUN	NN	Number=Sing	_	_	_	_
6	necrosis	necrosis	NOUN	NN	Number=Sing	_	_	_	_
7	factor	factor	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
8	-alpha	-alpha	NOUN	NN	Number=Sing	_	_	_	_
9	promoter	promoter	NOUN	NN	Number=Sing	_	_	_	_
10	in	in	ADP	IN	_	_	_	_	_
11	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
12	monocytic	monocytic	ADJ	JJ	Degree=Pos	_	_	_	_
13	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
14	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 807
# text = Regulation by Egr-1, c-Jun, and NF-kappaB transcription factors.
1	Regulation	regulation	NOUN	NN	Number=Sing	_	_	_	_
2	by	by	ADP	IN	_	_	_	_	_
3	Egr	Egr	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
4	-1	-1	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
5	,	,	PUNCT	,	_	_	_	_	_
6	c	class	NOUN	NN	Abbr=Yes|Number=Sing	_	_	_	SpaceAfter=No
7	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
8	Jun	Jun	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
9	,	,	PUNCT	,	_	_	_	_	_
10	and	and	CCONJ	CC	_	_	_	_	_
11	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
12	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
13	kappaB	kappaB	PROPN	NNP	Number=Sing	_	_	_	_
14	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
15	factors	factor	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
16	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 808
# text = Biosynthesis of tumor necrosis factor-alpha (TNF-alpha) is predominantly by cells of the monocytic lineage.
1	Biosynthesis	Biosynthesis	NOUN	NN	Number=Sing	_	_	_	_
2	of	of	ADP	IN	_	_	_	_	_
3	tumor	tumor	NOUN	NN	Number=Sing	_	_	_	_
4	necrosis	necrosis	NOUN	NN	Number=Sing	_	_	_	_
5	factor	factor	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
6	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
7	alpha	alpha	NOUN	NN	Number=Sing	_	_	_	_
8	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
9	TNF	Tnf	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
10	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
11	alpha	alpha	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
12	)	)	PUNCT	-RRB-	_	_	_	_	_
13	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
14	predominantly	predominantly	ADV	RB	_	_	_	_	_
15	by	by	ADP	IN	_	_	_	_	_
16	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
17	of	of	ADP	IN	_	_	_	_	_
18	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
19	monocytic	monocytic	ADJ	JJ	Degree=Pos	_	_	_	_
20	lineage	lineage	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
21	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 809
# text = This study examined the role of various cis-acting regulatory elements in the lipopolysaccharide (LPS) induction of the human TNF-alpha promoter in cells of monocytic lineage.
1	This	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
2	study	study	NOUN	NN	Number=Sing	_	_	_	_
3	examined	examin	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
4	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
5	role	role	NOUN	NN	Number=Sing	_	_	_	_
6	of	of	ADP	IN	_	_	_	_	_
7	various	various	ADJ	JJ	Degree=Pos	_	_	_	_
8	cis	cis	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
9	-acting	-act	VERB	VBG	VerbForm=Ger	_	_	_	_
10	regulatory	regulatory	ADJ	JJ	Degree=Pos	_	_	_	_
11	elements	element	NOUN	NNS	Number=Plur	_	_	_	_
12	in	in	ADP	IN	_	_	_	_	_
13	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
14	lipopolysaccharide	lipopolysaccharide	NOUN	NN	Number=Sing	_	_	_	_
15	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
16	LPS	LPS	INTJ	UH	_	_	_	_	SpaceAfter=No
17	)	)	PUNCT	-RRB-	_	_	_	_	_
18	induction	induction	NOUN	NN	Number=Sing	_	_	_	_
19	of	of	ADP	IN	_	_	_	_	_
20	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
21	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
22	TNF	Tnf	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
23	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
24	alpha	alpha	NOUN	NN	Number=Sing	_	_	_	_
25	promoter	promoter	NOUN	NN	Number=Sing	_	_	_	_
26	in	in	ADP	IN	_	_	_	_	_
27	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
28	of	of	ADP	IN	_	_	_	_	_
29	monocytic	monocytic	ADJ	JJ	Degree=Pos	_	_	_	_
30	lineage	lineage	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
31	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 810
# text = Functional analysis of monocytic THP-1 cells transfected with plasmids containing various lengths of TNF-alpha promoter localized enhancer elements in a region (-182 to -37 base pairs (bp)) that were required for optimal transcription of the TNF-alpha gene in response to LPS.
1	Functional	functional	ADJ	JJ	Degree=Pos	_	_	_	_
2	analysis	analysis	NOUN	NN	Number=Sing	_	_	_	_
3	of	of	ADP	IN	_	_	_	_	_
4	monocytic	monocytic	ADJ	JJ	Degree=Pos	_	_	_	_
5	THP	Thp	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
6	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
7	1	1	NUM	CD	NumType=Card	_	_	_	_
8	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
9	transfected	transfect	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
10	with	with	ADP	IN	_	_	_	_	_
11	plasmids	plasmid	NOUN	NNS	Number=Plur	_	_	_	_
12	containing	contain	VERB	VBG	VerbForm=Ger	_	_	_	_
13	various	various	ADJ	JJ	Degree=Pos	_	_	_	_
14	lengths	length	NOUN	NNS	Number=Plur	_	_	_	_
15	of	of	ADP	IN	_	_	_	_	_
16	TNF	TNF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
17	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
18	alpha	alpha	ADV	RB	_	_	_	_	_
19	promoter	promoter	ADV	RBR	Degree=Cmp	_	_	_	_
20	localized	localize	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
21	enhancer	enhancer	NOUN	NN	Number=Sing	_	_	_	_
22	elements	element	NOUN	NNS	Number=Plur	_	_	_	_
23	in	in	ADP	IN	_	_	_	_	_
24	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
25	region	region	NOUN	NN	Number=Sing	_	_	_	_
26	(-182	(-182	NOUN	NN	Number=Sing	_	_	_	_
27	to	to	ADP	IN	_	_	_	_	_
28	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
29	37	37	NUM	CD	NumType=Card	_	_	_	_
30	base	base	NOUN	NN	Number=Sing	_	_	_	_
31	pairs	pair	NOUN	NNS	Number=Plur	_	_	_	_
32	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
33	bp	bp	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
34	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
35	)	)	PUNCT	-RRB-	_	_	_	_	_
36	that	that	PRON	WDT	PronType=Rel	_	_	_	_
37	were	be	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
38	required	require	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
39	for	for	ADP	IN	_	_	_	_	_
40	optimal	optimal	ADJ	JJ	Degree=Pos	_	_	_	_
41	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
42	of	of	ADP	IN	_	_	_	_	_
43	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
44	TNF	Tnf	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
45	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
46	alpha	alpha	ADV	RB	_	_	_	_	_
47	gene	gene	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
48	in	in	ADP	IN	_	_	_	_	_
49	response	response	NOUN	NN	Number=Sing	_	_	_	_
50	to	to	ADP	IN	_	_	_	_	_
51	LPS	LPS	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
52	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 811
# text = Two regions were identified: region I (-182 to -162 bp) contained an overlapping Sp1/Egr-1 site, and region II (-119 to -88) contained CRE and NF-kappaB (designated kappaB3) sites.
1	Two	two	NUM	CD	NumType=Card	_	_	_	_
2	regions	region	NOUN	NNS	Number=Plur	_	_	_	_
3	were	be	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
4	identified	identify	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	SpaceAfter=No
5	:	:	PUNCT	:	_	_	_	_	_
6	region	region	NOUN	NN	Number=Sing	_	_	_	_
7	I	I	PRON	PRP	Case=Nom|Number=Sing|Person=1|PronType=Prs	_	_	_	_
8	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
9	-182	-182	NUM	CD	NumType=Card	_	_	_	_
10	to	to	ADP	IN	_	_	_	_	_
11	-	-	SYM	SYM	_	_	_	_	SpaceAfter=No
12	162	162	NUM	CD	NumType=Card	_	_	_	_
13	bp	bp	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
14	)	)	PUNCT	-RRB-	_	_	_	_	_
15	contained	contain	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
16	an	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
17	overlapping	overlapp	ADJ	JJ	Degree=Pos	_	_	_	_
18	Sp1/Egr	Sp1/Egr	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
19	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
20	1	1	NUM	CD	NumType=Card	_	_	_	_
21	site	site	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
22	,	,	PUNCT	,	_	_	_	_	_
23	and	and	CCONJ	CC	_	_	_	_	_
24	region	region	NOUN	NN	Number=Sing	_	_	_	_
25	II	ii	NUM	CD	NumType=Card	_	_	_	_
26	(-	(-	PUNCT	.	_	_	_	_	SpaceAfter=No
27	119	119	NUM	CD	NumType=Card	_	_	_	_
28	to	to	ADP	IN	_	_	_	_	_
29	-	-	SYM	SYM	_	_	_	_	SpaceAfter=No
30	88	88	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
31	)	)	PUNCT	-RRB-	_	_	_	_	_
32	contained	contain	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
33	CRE	CRE	PROPN	NNP	Number=Sing	_	_	_	_
34	and	and	CCONJ	CC	_	_	_	_	_
35	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
36	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
37	kappaB	kappaB	PROPN	NNP	Number=Sing	_	_	_	_
38	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
39	designated	designate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
40	kappaB3	kappaB3	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
41	)	)	PUNCT	-RRB-	_	_	_	_	_
42	sites	site	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
43	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 812
# text = In unstimulated THP-1, CRE-binding protein and, to a lesser extent, c-Jun complexes were found to bind to the CRE site.
1	In	in	ADP	IN	_	_	_	_	_
2	unstimulated	unstimulated	ADJ	JJ	Degree=Pos	_	_	_	_
3	THP	Thp	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
4	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
5	1	1	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
6	,	,	PUNCT	,	_	_	_	_	_
7	CRE	Cre	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
8	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
9	binding	binding	VERB	VBG	VerbForm=Ger	_	_	_	_
10	protein	protein	NOUN	NN	Number=Sing	_	_	_	_
11	and	and	CCONJ	CC	_	_	_	_	SpaceAfter=No
12	,	,	PUNCT	,	_	_	_	_	_
13	to	to	ADP	IN	_	_	_	_	_
14	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
15	lesser	lesser	ADJ	JJR	Degree=Cmp	_	_	_	_
16	extent	extent	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
17	,	,	PUNCT	,	_	_	_	_	_
18	c	c	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
19	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
20	Jun	Jun	PROPN	NNP	Number=Sing	_	_	_	_
21	complexes	complex	NOUN	NNS	Number=Plur	_	_	_	_
22	were	be	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
23	found	find	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
24	to	to	PART	TO	_	_	_	_	_
25	bind	bind	VERB	VB	VerbForm=Inf	_	_	_	_
26	to	to	ADP	IN	_	_	_	_	_
27	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
28	CRE	Cre	PROPN	NNP	Number=Sing	_	_	_	_
29	site	site	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
30	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 813
# text = LPS stimulation increased the binding of c-Jun-containing complexes.
1	LPS	Lps	ADJ	JJ	Degree=Pos	_	_	_	_
2	stimulation	stimulation	NOUN	NN	Number=Sing	_	_	_	_
3	increased	increase	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
4	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
5	binding	binding	NOUN	NN	Number=Sing	_	_	_	_
6	of	of	ADP	IN	_	_	_	_	_
7	c	c	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
8	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
9	Jun	Jun	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
10	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
11	containing	containing	VERB	VBG	VerbForm=Ger	_	_	_	_
12	complexes	complex	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
13	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 814
# text = In addition, LPS stimulation induced the binding of cognate nuclear factors to the Egr-1 and kappaB3 sites, which were identified as Egr-1 and p50/p65, respectively.
1	In	in	ADP	IN	_	_	_	_	_
2	addition	addition	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
3	,	,	PUNCT	,	_	_	_	_	_
4	LPS	LPS	PROPN	NNP	Number=Sing	_	_	_	_
5	stimulation	stimulation	NOUN	NN	Number=Sing	_	_	_	_
6	induced	induce	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
7	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
8	binding	binding	NOUN	NN	Number=Sing	_	_	_	_
9	of	of	ADP	IN	_	_	_	_	_
10	cognate	cognate	ADJ	JJ	Degree=Pos	_	_	_	_
11	nuclear	nuclear	ADJ	JJ	Degree=Pos	_	_	_	_
12	factors	factor	NOUN	NNS	Number=Plur	_	_	_	_
13	to	to	ADP	IN	_	_	_	_	_
14	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
15	Egr	Egr	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
16	-1	-1	NUM	CD	NumType=Card	_	_	_	_
17	and	and	CCONJ	CC	_	_	_	_	_
18	kappaB3	kappaB3	NUM	CD	NumType=Card	_	_	_	_
19	sites	site	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
20	,	,	PUNCT	,	_	_	_	_	_
21	which	which	PRON	WDT	PronType=Rel	_	_	_	_
22	were	be	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
23	identified	identify	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
24	as	as	ADP	IN	_	_	_	_	_
25	Egr	Egr	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
26	-1	-1	NUM	CD	NumType=Card	_	_	_	_
27	and	and	CCONJ	CC	_	_	_	_	_
28	p50/	p50/	SYM	SYM	_	_	_	_	SpaceAfter=No
29	p65	p65	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
30	,	,	PUNCT	,	_	_	_	_	_
31	respectively	respectively	ADV	RB	_	_	_	_	SpaceAfter=No
32	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 815
# text = The CRE and kappaB3 sites in region II together conferred strong LPS responsiveness to a heterologous promoter, whereas individually they failed to provide transcriptional activation.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	CRE	Cre	NOUN	NN	Number=Sing	_	_	_	_
3	and	and	CCONJ	CC	_	_	_	_	_
4	kappaB3	kappaB3	NOUN	NN	Number=Sing	_	_	_	_
5	sites	site	NOUN	NNS	Number=Plur	_	_	_	_
6	in	in	ADP	IN	_	_	_	_	_
7	region	region	NOUN	NN	Number=Sing	_	_	_	_
8	II	ii	NUM	CD	NumType=Card	_	_	_	_
9	together	together	ADV	RB	_	_	_	_	_
10	conferred	confer	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
11	strong	strong	ADJ	JJ	Degree=Pos	_	_	_	_
12	LPS	Lps	NOUN	NN	Number=Sing	_	_	_	_
13	responsiveness	responsiveness	NOUN	NN	Number=Sing	_	_	_	_
14	to	to	ADP	IN	_	_	_	_	_
15	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
16	heterologous	heterologous	ADJ	JJ	Degree=Pos	_	_	_	_
17	promoter	promoter	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
18	,	,	PUNCT	,	_	_	_	_	_
19	whereas	whereas	SCONJ	IN	_	_	_	_	_
20	individually	individually	ADV	RB	_	_	_	_	_
21	they	they	PRON	PRP	Case=Nom|Number=Plur|Person=3|PronType=Prs	_	_	_	_
22	failed	fail	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
23	to	to	PART	TO	_	_	_	_	_
24	provide	provide	VERB	VB	VerbForm=Inf	_	_	_	_
25	transcriptional	transcriptional	ADJ	JJ	Degree=Pos	_	_	_	_
26	activation	activation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
27	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 816
# text = Furthermore, increasing the spacing between the CRE and the kappaB3 sites completely abolished LPS induction, suggesting a cooperative interaction between c-Jun complexes and p50/p65.
1	Furthermore	furthermore	ADV	RB	_	_	_	_	SpaceAfter=No
2	,	,	PUNCT	,	_	_	_	_	_
3	increasing	increase	VERB	VBG	VerbForm=Ger	_	_	_	_
4	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
5	spacing	spacing	NOUN	NN	Number=Sing	_	_	_	_
6	between	between	ADP	IN	_	_	_	_	_
7	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
8	CRE	Cre	NOUN	NN	Number=Sing	_	_	_	_
9	and	and	CCONJ	CC	_	_	_	_	_
10	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
11	kappaB3	kappaB3	NOUN	NN	Number=Sing	_	_	_	_
12	sites	site	NOUN	NNS	Number=Plur	_	_	_	_
13	completely	completely	ADV	RB	_	_	_	_	_
14	abolished	abolish	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
15	LPS	Lps	NOUN	NN	Number=Sing	_	_	_	_
16	induction	induction	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
17	,	,	PUNCT	,	_	_	_	_	_
18	suggesting	suggest	VERB	VBG	VerbForm=Ger	_	_	_	_
19	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
20	cooperative	cooperative	ADJ	JJ	Degree=Pos	_	_	_	_
21	interaction	interaction	NOUN	NN	Number=Sing	_	_	_	_
22	between	between	ADP	IN	_	_	_	_	_
23	c	c	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
24	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
25	Jun	Jun	PROPN	NNP	Number=Sing	_	_	_	_
26	complexes	complex	NOUN	NNS	Number=Plur	_	_	_	_
27	and	and	CCONJ	CC	_	_	_	_	_
28	p50/	p50ith	ADP	IN	Abbr=Yes	_	_	_	SpaceAfter=No
29	p65	p65	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
30	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 817
# text = These studies indicate that maximal LPS induction of the TNF-alpha promoter is mediated by concerted participation of at least two separate cis-acting regulatory elements.
1	These	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
2	studies	study	NOUN	NNS	Number=Plur	_	_	_	_
3	indicate	indicate	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
4	that	that	SCONJ	IN	_	_	_	_	_
5	maximal	maximal	ADJ	JJ	Degree=Pos	_	_	_	_
6	LPS	Lps	NOUN	NN	Number=Sing	_	_	_	_
7	induction	induction	NOUN	NN	Number=Sing	_	_	_	_
8	of	of	ADP	IN	_	_	_	_	_
9	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
10	TNF	Tnf	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
11	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
12	alpha	alpha	NOUN	NN	Number=Sing	_	_	_	_
13	promoter	promoter	NOUN	NN	Number=Sing	_	_	_	_
14	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
15	mediated	mediate	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
16	by	by	ADP	IN	_	_	_	_	_
17	concerted	concert	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
18	participation	participation	NOUN	NN	Number=Sing	_	_	_	_
19	of	of	ADP	IN	_	_	_	_	_
20	at	at	ADV	RB	_	_	_	_	_
21	least	least	ADV	RBS	Degree=Sup	_	_	_	_
22	two	two	NUM	CD	NumType=Card	_	_	_	_
23	separate	separate	ADJ	JJ	Degree=Pos	_	_	_	_
24	cis	cis	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
25	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
26	acting	acting	VERB	VBG	VerbForm=Ger	_	_	_	_
27	regulatory	regulatory	ADJ	JJ	Degree=Pos	_	_	_	_
28	elements	element	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
29	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 818
# text = Document 003002291 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	003002291	003002291	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 819
# text = Synergism between the CD3 antigen- and CD2 antigen-derived signals.
1	Synergism	Synergism	NOUN	NN	Number=Sing	_	_	_	_
2	between	between	ADP	IN	_	_	_	_	_
3	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
4	CD3	CD3	NOUN	NN	Number=Sing	_	_	_	_
5	antigen	antigen	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
6	-	-	PUNCT	,	_	_	_	_	_
7	and	and	CCONJ	CC	_	_	_	_	_
8	CD2	CD2	NOUN	NN	Number=Sing	_	_	_	_
9	antigen	antigen	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
10	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
11	derived	derive	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
12	signals	signal	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
13	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 820
# text = Exploration at the level of induction of DNA-binding proteins and characterization of the inhibitory activity of cyclosporine.
1	Exploration	exploration	NOUN	NN	Number=Sing	_	_	_	_
2	at	at	ADP	IN	_	_	_	_	_
3	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
4	level	level	NOUN	NN	Number=Sing	_	_	_	_
5	of	of	ADP	IN	_	_	_	_	_
6	induction	induction	NOUN	NN	Number=Sing	_	_	_	_
7	of	of	ADP	IN	_	_	_	_	_
8	DNA	dna	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
9	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
10	binding	bind	VERB	VBG	VerbForm=Ger	_	_	_	_
11	proteins	protein	NOUN	NNS	Number=Plur	_	_	_	_
12	and	and	CCONJ	CC	_	_	_	_	_
13	characterization	characterization	NOUN	NN	Number=Sing	_	_	_	_
14	of	of	ADP	IN	_	_	_	_	_
15	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
16	inhibitory	inhibitory	ADJ	JJ	Degree=Pos	_	_	_	_
17	activity	activity	NOUN	NN	Number=Sing	_	_	_	_
18	of	of	ADP	IN	_	_	_	_	_
19	cyclosporine	cyclosporine	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
20	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 821
# text = We have demonstrated earlier that the crosslinkage of the CD3/TCR complex with the CD2 antigen results in the proliferation of normal human T cells.
1	We	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
2	have	have	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
3	demonstrated	demonstrate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
4	earlier	earlier	ADV	RBR	Degree=Cmp	_	_	_	_
5	that	that	SCONJ	IN	_	_	_	_	_
6	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
7	crosslinkage	crosslinkage	NOUN	NN	Number=Sing	_	_	_	_
8	of	of	ADP	IN	_	_	_	_	_
9	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
10	CD3/TCR	Cd3/tcr	PROPN	NNP	Number=Sing	_	_	_	_
11	complex	complex	NOUN	NN	Number=Sing	_	_	_	_
12	with	with	ADP	IN	_	_	_	_	_
13	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
14	CD2	Cd2	NOUN	NN	Number=Sing	_	_	_	_
15	antigen	antigen	ADJ	JJ	Degree=Pos	_	_	_	_
16	results	result	NOUN	NNS	Number=Plur	_	_	_	_
17	in	in	ADP	IN	_	_	_	_	_
18	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
19	proliferation	proliferation	NOUN	NN	Number=Sing	_	_	_	_
20	of	of	ADP	IN	_	_	_	_	_
21	normal	normal	ADJ	JJ	Degree=Pos	_	_	_	_
22	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
23	T	t	PROPN	NNP	Number=Sing	_	_	_	_
24	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
25	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 822
# text = The effect of this synergism was perceptible at the level of induction of the IL-2 gene, a process critical for T cell growth.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	effect	effect	NOUN	NN	Number=Sing	_	_	_	_
3	of	of	ADP	IN	_	_	_	_	_
4	this	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
5	synergism	synergism	NOUN	NN	Number=Sing	_	_	_	_
6	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
7	perceptible	perceptible	ADJ	JJ	Degree=Pos	_	_	_	_
8	at	at	ADP	IN	_	_	_	_	_
9	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
10	level	level	NOUN	NN	Number=Sing	_	_	_	_
11	of	of	ADP	IN	_	_	_	_	_
12	induction	induction	NOUN	NN	Number=Sing	_	_	_	_
13	of	of	ADP	IN	_	_	_	_	_
14	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
15	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
16	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
17	2	2	NUM	CD	NumType=Card	_	_	_	_
18	gene	gene	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
19	,	,	PUNCT	,	_	_	_	_	_
20	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
21	process	process	NOUN	NN	Number=Sing	_	_	_	_
22	critical	critical	ADJ	JJ	Degree=Pos	_	_	_	_
23	for	for	ADP	IN	_	_	_	_	_
24	T	t	PROPN	NNP	Number=Sing	_	_	_	_
25	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
26	growth	growth	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
27	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 823
# text = To further understand the molecular and nuclear basis for this synergism, we have explored the induction of DNA-binding proteins in highly purified normal human T cells signaled via the CD3 and/or CD2 proteins.
1	To	to	PART	TO	_	_	_	_	_
2	further	further	ADV	RB	_	_	_	_	_
3	understand	understand	VERB	VB	VerbForm=Inf	_	_	_	_
4	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
5	molecular	molecular	ADJ	JJ	Degree=Pos	_	_	_	_
6	and	and	CCONJ	CC	_	_	_	_	_
7	nuclear	nuclear	ADJ	JJ	Degree=Pos	_	_	_	_
8	basis	basis	NOUN	NN	Number=Sing	_	_	_	_
9	for	for	ADP	IN	_	_	_	_	_
10	this	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
11	synergism	synergism	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
12	,	,	PUNCT	,	_	_	_	_	_
13	we	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
14	have	have	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
15	explored	explore	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
16	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
17	induction	induction	NOUN	NN	Number=Sing	_	_	_	_
18	of	of	ADP	IN	_	_	_	_	_
19	DNA	dna	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
20	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
21	binding	binding	VERB	VBG	VerbForm=Ger	_	_	_	_
22	proteins	protein	NOUN	NNS	Number=Plur	_	_	_	_
23	in	in	ADP	IN	_	_	_	_	_
24	highly	highly	ADV	RB	_	_	_	_	_
25	purified	purified	ADJ	JJ	Degree=Pos	_	_	_	_
26	normal	normal	ADJ	JJ	Degree=Pos	_	_	_	_
27	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
28	T	t	PROPN	NNP	Number=Sing	_	_	_	_
29	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
30	signaled	signale	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
31	via	via	ADP	IN	_	_	_	_	_
32	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
33	CD3	CD3	NOUN	NN	Number=Sing	_	_	_	_
34	and	and	CCONJ	CC	_	_	_	_	SpaceAfter=No
35	/	/	PUNCT	,	_	_	_	_	SpaceAfter=No
36	or	or	CCONJ	CC	_	_	_	_	_
37	CD2	CD2	NOUN	NN	Number=Sing	_	_	_	_
38	proteins	protein	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
39	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 824
# text = The effect of transmembrane signaling of T cells with ionomycin, and/or sn-1,2 dioctanoyl glycerol, was also determined.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	effect	effect	NOUN	NN	Number=Sing	_	_	_	_
3	of	of	ADP	IN	_	_	_	_	_
4	transmembrane	transmembrane	NOUN	NN	Number=Sing	_	_	_	_
5	signaling	signaling	NOUN	NN	Number=Sing	_	_	_	_
6	of	of	ADP	IN	_	_	_	_	_
7	T	t	PROPN	NNP	Number=Sing	_	_	_	_
8	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
9	with	with	ADP	IN	_	_	_	_	_
10	ionomycin	ionomycin	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
11	,	,	PUNCT	,	_	_	_	_	_
12	and	and	CCONJ	CC	_	_	_	_	SpaceAfter=No
13	/	/	PUNCT	,	_	_	_	_	SpaceAfter=No
14	or	or	CCONJ	CC	_	_	_	_	_
15	sn	sn	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
16	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
17	1	1	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
18	,2	,2	NUM	CD	NumType=Card	_	_	_	_
19	dioctanoyl	dioctanoyl	NOUN	NN	Number=Sing	_	_	_	_
20	glycerol	glycerol	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
21	,	,	PUNCT	,	_	_	_	_	_
22	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
23	also	also	ADV	RB	_	_	_	_	_
24	determined	determined	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
25	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 825
# text = The emergence of nuclear binding proteins was investigated using interleukin-2 sequence specific oligonucleotide probes in the electrophoretic mobility shift assay.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	emergence	emergence	NOUN	NN	Number=Sing	_	_	_	_
3	of	of	ADP	IN	_	_	_	_	_
4	nuclear	nuclear	ADJ	JJ	Degree=Pos	_	_	_	_
5	binding	binding	VERB	VBG	VerbForm=Ger	_	_	_	_
6	proteins	protein	NOUN	NNS	Number=Plur	_	_	_	_
7	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
8	investigated	investigate	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
9	using	use	VERB	VBG	VerbForm=Ger	_	_	_	_
10	interleukin	interleukin	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
11	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
12	2	2	NUM	CD	NumType=Card	_	_	_	_
13	sequence	sequence	NOUN	NN	Number=Sing	_	_	_	_
14	specific	specific	ADJ	JJ	Degree=Pos	_	_	_	_
15	oligonucleotide	oligonucleotide	ADJ	JJ	Degree=Pos	_	_	_	_
16	probes	probe	NOUN	NNS	Number=Plur	_	_	_	_
17	in	in	ADP	IN	_	_	_	_	_
18	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
19	electrophoretic	electrophoretic	ADJ	JJ	Degree=Pos	_	_	_	_
20	mobility	mobility	NOUN	NN	Number=Sing	_	_	_	_
21	shift	shift	NOUN	NN	Number=Sing	_	_	_	_
22	assay	assay	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
23	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 826
# text = Our studies demonstrate for the first time that CD3 antigen-derived signals and CD2 antigen-derived signals are synergistic in inducing the emergence of transcription factors that bind to the NF-AT1, AP-1, and NF-kB sites located in the promoter/enhancer region of the IL-2 gene.
1	Our	we	PRON	PRP$	Number=Plur|Person=1|Poss=Yes|PronType=Prs	_	_	_	_
2	studies	study	NOUN	NNS	Number=Plur	_	_	_	_
3	demonstrate	demonstrate	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
4	for	for	ADP	IN	_	_	_	_	_
5	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
6	first	first	ADJ	JJ	Degree=Pos|NumType=Ord	_	_	_	_
7	time	time	NOUN	NN	Number=Sing	_	_	_	_
8	that	that	PRON	WDT	PronType=Rel	_	_	_	_
9	CD3	CD3	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
10	antigen	antigen	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
11	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
12	derived	derive	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
13	signals	signal	NOUN	NNS	Number=Plur	_	_	_	_
14	and	and	CCONJ	CC	_	_	_	_	_
15	CD2	CD2	NOUN	NN	Number=Sing	_	_	_	_
16	antigen	antigen	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
17	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
18	derived	derive	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
19	signals	signal	NOUN	NNS	Number=Plur	_	_	_	_
20	are	be	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
21	synergistic	synergistic	ADJ	JJ	Degree=Pos	_	_	_	_
22	in	in	SCONJ	IN	_	_	_	_	_
23	inducing	induce	VERB	VBG	VerbForm=Ger	_	_	_	_
24	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
25	emergence	emergence	NOUN	NN	Number=Sing	_	_	_	_
26	of	of	ADP	IN	_	_	_	_	_
27	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
28	factors	factor	NOUN	NNS	Number=Plur	_	_	_	_
29	that	that	PRON	WDT	PronType=Rel	_	_	_	_
30	bind	bind	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
31	to	to	ADP	IN	_	_	_	_	_
32	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
33	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
34	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
35	AT1	AT1	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
36	,	,	PUNCT	,	_	_	_	_	_
37	AP	Ap	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
38	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
39	1	1	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
40	,	,	PUNCT	,	_	_	_	_	_
41	and	and	CCONJ	CC	_	_	_	_	_
42	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
43	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
44	kB	kb	PROPN	NNP	Number=Sing	_	_	_	_
45	sites	site	NOUN	NNS	Number=Plur	_	_	_	_
46	located	locate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
47	in	in	ADP	IN	_	_	_	_	_
48	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
49	promoter	promoter	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
50	/	/	PUNCT	,	_	_	_	_	SpaceAfter=No
51	enhancer	enhancer	NOUN	NN	Number=Sing	_	_	_	_
52	region	region	NOUN	NN	Number=Sing	_	_	_	_
53	of	of	ADP	IN	_	_	_	_	_
54	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
55	IL	Il	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
56	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
57	2	2	NUM	CD	NumType=Card	_	_	_	_
58	gene	gene	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
59	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 827
# text = Moreover, cyclosporine, at concentrations readily accomplished in clinical practice, was found to inhibit the emergence of these DNA-binding proteins in normal human T cells signaled via cell surface proteins implicated in antigen-dependent
1	Moreover	moreover	ADV	RB	_	_	_	_	SpaceAfter=No
2	,	,	PUNCT	,	_	_	_	_	_
3	cyclosporine	cyclosporine	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
4	,	,	PUNCT	,	_	_	_	_	_
5	at	at	ADP	IN	_	_	_	_	_
6	concentrations	concentration	NOUN	NNS	Number=Plur	_	_	_	_
7	readily	readily	ADV	RB	_	_	_	_	_
8	accomplished	accomplish	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
9	in	in	ADP	IN	_	_	_	_	_
10	clinical	clinical	ADJ	JJ	Degree=Pos	_	_	_	_
11	practice	practice	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
12	,	,	PUNCT	,	_	_	_	_	_
13	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
14	found	find	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
15	to	to	PART	TO	_	_	_	_	_
16	inhibit	inhibit	VERB	VB	VerbForm=Inf	_	_	_	_
17	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
18	emergence	emergence	NOUN	NN	Number=Sing	_	_	_	_
19	of	of	ADP	IN	_	_	_	_	_
20	these	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
21	DNA	dna	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
22	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
23	binding	binding	VERB	VBG	VerbForm=Ger	_	_	_	_
24	proteins	protein	NOUN	NNS	Number=Plur	_	_	_	_
25	in	in	ADP	IN	_	_	_	_	_
26	normal	normal	ADJ	JJ	Degree=Pos	_	_	_	_
27	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
28	T	t	PROPN	NNP	Number=Sing	_	_	_	_
29	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
30	signaled	signale	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
31	via	via	ADP	IN	_	_	_	_	_
32	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
33	surface	surface	NOUN	NN	Number=Sing	_	_	_	_
34	proteins	protein	NOUN	NNS	Number=Plur	_	_	_	_
35	implicated	implicate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
36	in	in	ADP	IN	_	_	_	_	_
37	antigen	antigen	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
38	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
39	dependent	dependent	ADJ	JJ	Degree=Pos	_	_	_	_

# sent_id = 828
# text = T cell activation and in T cells stimulated by mobilization of cellular calcium and activation of protein kinase C.
1	T	t	PROPN	NNP	Number=Sing	_	_	_	_
2	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
3	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
4	and	and	CCONJ	CC	_	_	_	_	_
5	in	in	ADP	IN	_	_	_	_	_
6	T	t	PROPN	NNP	Number=Sing	_	_	_	_
7	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
8	stimulated	stimulate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
9	by	by	ADP	IN	_	_	_	_	_
10	mobilization	mobilization	NOUN	NN	Number=Sing	_	_	_	_
11	of	of	ADP	IN	_	_	_	_	_
12	cellular	cellular	ADJ	JJ	Degree=Pos	_	_	_	_
13	calcium	calcium	NOUN	NN	Number=Sing	_	_	_	_
14	and	and	CCONJ	CC	_	_	_	_	_
15	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
16	of	of	ADP	IN	_	_	_	_	_
17	protein	protein	NOUN	NN	Number=Sing	_	_	_	_
18	kinase	kinase	NOUN	NN	Number=Sing	_	_	_	_
19	C	C	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
20	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 829
# text = Document 003002298 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	003002298	003002298	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 830
# text = Monocytic cell type-specific transcriptional induction of collagenase.
1	Monocytic	Monocytic	ADJ	JJ	Degree=Pos	_	_	_	_
2	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
3	type	type	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
4	-	-	PUNCT	:	_	_	_	_	SpaceAfter=No
5	specific	specific	ADJ	JJ	Degree=Pos	_	_	_	_
6	transcriptional	transcriptional	ADJ	JJ	Degree=Pos	_	_	_	_
7	induction	induction	NOUN	NN	Number=Sing	_	_	_	_
8	of	of	ADP	IN	_	_	_	_	_
9	collagenase	collagenase	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
10	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 831
# text = Interstitial collagenase (MMP-1), a metalloproteinase produced by resident and inflammatory cells during connective tissue turnover, cleaves type I collagen fibrils.
1	Interstitial	Interstitial	ADJ	JJ	Degree=Pos	_	_	_	_
2	collagenase	collagenase	NOUN	NN	Number=Sing	_	_	_	_
3	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
4	MMP	Mmp	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
5	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
6	1	1	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
7	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
8	,	,	PUNCT	,	_	_	_	_	_
9	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
10	metalloproteinase	metalloproteinase	NOUN	NN	Number=Sing	_	_	_	_
11	produced	produce	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
12	by	by	ADP	IN	_	_	_	_	_
13	resident	resident	NOUN	NN	Number=Sing	_	_	_	_
14	and	and	CCONJ	CC	_	_	_	_	_
15	inflammatory	inflammatory	ADJ	JJ	Degree=Pos	_	_	_	_
16	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
17	during	during	ADP	IN	_	_	_	_	_
18	connective	connective	ADJ	JJ	Degree=Pos	_	_	_	_
19	tissue	tissue	NOUN	NN	Number=Sing	_	_	_	_
20	turnover	turnover	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
21	,	,	PUNCT	,	_	_	_	_	_
22	cleaves	cleave	NOUN	NNS	Number=Plur	_	_	_	_
23	type	type	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
24	I	I	PRON	PRP	Case=Nom|Number=Sing|Person=1|PronType=Prs	_	_	_	_
25	collagen	collagen	ADJ	JJ	Degree=Pos	_	_	_	_
26	fibrils	fibril	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
27	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 832
# text = This catalytic event is rate limiting in remodeling of tissues rich in fibrillar collagen such as the skin and lungs.
1	This	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
2	catalytic	catalytic	ADJ	JJ	Degree=Pos	_	_	_	_
3	event	event	NOUN	NN	Number=Sing	_	_	_	_
4	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
5	rate	rate	NOUN	NN	Number=Sing	_	_	_	_
6	limiting	limit	VERB	VBG	VerbForm=Ger	_	_	_	_
7	in	in	ADP	IN	_	_	_	_	_
8	remodeling	remodeling	NOUN	NN	Number=Sing	_	_	_	_
9	of	of	ADP	IN	_	_	_	_	_
10	tissues	tissue	NOUN	NNS	Number=Plur	_	_	_	_
11	rich	rich	ADJ	JJ	Degree=Pos	_	_	_	_
12	in	in	ADP	IN	_	_	_	_	_
13	fibrillar	fibrillar	ADJ	JJ	Degree=Pos	_	_	_	_
14	collagen	collagen	NOUN	NNS	Number=Plur	_	_	_	_
15	such	such	ADJ	JJ	Degree=Pos	_	_	_	_
16	as	as	ADP	IN	_	_	_	_	_
17	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
18	skin	skin	NOUN	NN	Number=Sing	_	_	_	_
19	and	and	CCONJ	CC	_	_	_	_	_
20	lungs	lung	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
21	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 833
# text = The regulation of collagenase expression is cell-type specific; bacterial LPS and zymosan, a yeast cell wall derivative, are potent inducers of collagenase expression in macrophages, but do not alter fibroblast collagenase expression.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	regulation	regulation	NOUN	NN	Number=Sing	_	_	_	_
3	of	of	ADP	IN	_	_	_	_	_
4	collagenase	collagenase	NOUN	NN	Number=Sing	_	_	_	_
5	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
6	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
7	cell	cell	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
8	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
9	type	type	NOUN	NN	Number=Sing	_	_	_	_
10	specific	specific	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
11	;	;	PUNCT	,	_	_	_	_	_
12	bacterial	bacterial	ADJ	JJ	Degree=Pos	_	_	_	_
13	LPS	Lps	NOUN	NNS	Number=Plur	_	_	_	_
14	and	and	CCONJ	CC	_	_	_	_	_
15	zymosan	zymosan	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
16	,	,	PUNCT	,	_	_	_	_	_
17	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
18	yeast	yeast	ADJ	JJ	Degree=Pos	_	_	_	_
19	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
20	wall	wall	NOUN	NN	Number=Sing	_	_	_	_
21	derivative	derivative	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
22	,	,	PUNCT	,	_	_	_	_	_
23	are	be	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
24	potent	potent	ADJ	JJ	Degree=Pos	_	_	_	_
25	inducers	inducer	NOUN	NNS	Number=Plur	_	_	_	_
26	of	of	ADP	IN	_	_	_	_	_
27	collagenase	collagenase	NOUN	NN	Number=Sing	_	_	_	_
28	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
29	in	in	ADP	IN	_	_	_	_	_
30	macrophages	macrophage	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
31	,	,	PUNCT	,	_	_	_	_	_
32	but	but	CCONJ	CC	_	_	_	_	_
33	do	do	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
34	not	not	PART	RB	_	_	_	_	_
35	alter	alter	VERB	VB	VerbForm=Inf	_	_	_	_
36	fibroblast	fibroblast	ADJ	JJ	Degree=Pos	_	_	_	_
37	collagenase	collagenase	NOUN	NN	Number=Sing	_	_	_	_
38	expression	expression	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
39	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 834
# text = Since promoter elements controlling collagenase transcription in monocytic cells have not been previously defined, we sought to delineate responsive cis-acting elements of the collagenase promoter in transiently transfected human (U937) and murine (J774) monocytic cell lines.
1	Since	since	SCONJ	IN	_	_	_	_	_
2	promoter	promoter	NOUN	NN	Number=Sing	_	_	_	_
3	elements	element	NOUN	NNS	Number=Plur	_	_	_	_
4	controlling	controlle	VERB	VBG	VerbForm=Ger	_	_	_	_
5	collagenase	collagenase	NOUN	NN	Number=Sing	_	_	_	_
6	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
7	in	in	ADP	IN	_	_	_	_	_
8	monocytic	monocytic	ADJ	JJ	Degree=Pos	_	_	_	_
9	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
10	have	have	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
11	not	not	PART	RB	_	_	_	_	_
12	been	be	AUX	VBN	Tense=Past|VerbForm=Part	_	_	_	_
13	previously	previously	ADV	RB	_	_	_	_	_
14	defined	define	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	SpaceAfter=No
15	,	,	PUNCT	,	_	_	_	_	_
16	we	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
17	sought	seek	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
18	to	to	PART	TO	_	_	_	_	_
19	delineate	delineate	VERB	VB	VerbForm=Inf	_	_	_	_
20	responsive	responsive	ADJ	JJ	Degree=Pos	_	_	_	_
21	cis	cis	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
22	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
23	acting	acte	VERB	VBG	VerbForm=Ger	_	_	_	_
24	elements	element	NOUN	NNS	Number=Plur	_	_	_	_
25	of	of	ADP	IN	_	_	_	_	_
26	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
27	collagenase	collagenase	NOUN	NN	Number=Sing	_	_	_	_
28	promoter	promoter	NOUN	NN	Number=Sing	_	_	_	_
29	in	in	ADP	IN	_	_	_	_	_
30	transiently	transiently	ADV	RB	_	_	_	_	_
31	transfected	transfect	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
32	human	human	NOUN	NN	Number=Sing	_	_	_	_
33	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
34	U937	U937	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
35	)	)	PUNCT	-RRB-	_	_	_	_	_
36	and	and	CCONJ	CC	_	_	_	_	_
37	murine	murine	NOUN	NN	Number=Sing	_	_	_	_
38	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
39	J774	J774	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
40	)	)	PUNCT	-RRB-	_	_	_	_	_
41	monocytic	monocytic	ADJ	JJ	Degree=Pos	_	_	_	_
42	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
43	lines	line	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
44	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 835
# text = Deletion constructs containing as little as 72 bp of 5' -flanking sequence of the collagenase promoter were sufficient for LPS- or zymosan-mediated transcriptional induction, whereas phorbol inducibility exhibited an absolute requirement for upstream elements including the polyoma enhancer A-binding protein-3 site (-83 to -91) and TTCA sequence (-102 to -105) in both monocytic cells and fibroblasts.
1	Deletion	Deletion	NOUN	NN	Number=Sing	_	_	_	_
2	constructs	construct	NOUN	NNS	Number=Plur	_	_	_	_
3	containing	contain	VERB	VBG	VerbForm=Ger	_	_	_	_
4	as	as	ADV	RB	_	_	_	_	_
5	little	little	ADJ	JJ	Degree=Pos	_	_	_	_
6	as	as	ADP	IN	_	_	_	_	_
7	72	72	NUM	CD	NumType=Card	_	_	_	_
8	bp	bp	NOUN	NN	Number=Sing	_	_	_	_
9	of	of	ADP	IN	_	_	_	_	_
10	5	5	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
11	'	'	PUNCT	''	_	_	_	_	_
12	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
13	flanking	flank	VERB	VBG	VerbForm=Ger	_	_	_	_
14	sequence	sequence	NOUN	NN	Number=Sing	_	_	_	_
15	of	of	ADP	IN	_	_	_	_	_
16	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
17	collagenase	collagenase	NOUN	NN	Number=Sing	_	_	_	_
18	promoter	promoter	NOUN	NN	Number=Sing	_	_	_	_
19	were	be	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
20	sufficient	sufficient	ADJ	JJ	Degree=Pos	_	_	_	_
21	for	for	ADP	IN	_	_	_	_	_
22	LPS	LPS	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
23	-	-	PUNCT	,	_	_	_	_	_
24	or	or	CCONJ	CC	_	_	_	_	_
25	zymosan	zymosan	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
26	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
27	mediated	mediate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
28	transcriptional	transcriptional	ADJ	JJ	Degree=Pos	_	_	_	_
29	induction	induction	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
30	,	,	PUNCT	,	_	_	_	_	_
31	whereas	whereas	SCONJ	IN	_	_	_	_	_
32	phorbol	phorbol	ADJ	JJ	Degree=Pos	_	_	_	_
33	inducibility	inducibility	NOUN	NN	Number=Sing	_	_	_	_
34	exhibited	exhibit	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
35	an	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
36	absolute	absolute	ADJ	JJ	Degree=Pos	_	_	_	_
37	requirement	requirement	NOUN	NN	Number=Sing	_	_	_	_
38	for	for	ADP	IN	_	_	_	_	_
39	upstream	upstream	ADJ	JJ	Degree=Pos	_	_	_	_
40	elements	element	NOUN	NNS	Number=Plur	_	_	_	_
41	including	include	VERB	VBG	VerbForm=Ger	_	_	_	_
42	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
43	polyoma	polyoma	NOUN	NN	Number=Sing	_	_	_	_
44	enhancer	enhancer	NOUN	NN	Number=Sing	_	_	_	_
45	A-	A-	PUNCT	:	_	_	_	_	SpaceAfter=No
46	binding	bind	VERB	VBG	VerbForm=Ger	_	_	_	_
47	protein	protein	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
48	-3	-3	NUM	CD	NumType=Card	_	_	_	_
49	site	site	NOUN	NN	Number=Sing	_	_	_	_
50	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
51	-	-	SYM	SYM	_	_	_	_	SpaceAfter=No
52	83	83	NUM	CD	NumType=Card	_	_	_	_
53	to	to	ADP	IN	_	_	_	_	_
54	-	-	SYM	SYM	_	_	_	_	SpaceAfter=No
55	91	91	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
56	)	)	PUNCT	-RRB-	_	_	_	_	_
57	and	and	CCONJ	CC	_	_	_	_	_
58	TTCA	Ttca	PROPN	NNP	Number=Sing	_	_	_	_
59	sequence	sequence	NOUN	NN	Number=Sing	_	_	_	_
60	(-	(-	PUNCT	.	_	_	_	_	SpaceAfter=No
61	102	102	NUM	CD	NumType=Card	_	_	_	_
62	to	to	ADP	IN	_	_	_	_	_
63	-	-	SYM	SYM	_	_	_	_	SpaceAfter=No
64	105	105	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
65	)	)	PUNCT	-RRB-	_	_	_	_	_
66	in	in	ADP	IN	_	_	_	_	_
67	both	both	DET	DT	_	_	_	_	_
68	monocytic	monocytic	ADJ	JJ	Degree=Pos	_	_	_	_
69	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
70	and	and	CCONJ	CC	_	_	_	_	_
71	fibroblasts	fibroblast	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
72	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 836
# text = Mutagenesis of the activator protein-1 [AP-1] site at -72 abolished basal promoter activity and LPS/zymosan inducibility, while mutagenesis of an NF-kappaB-like site at -20 to -10 had no effect.
1	Mutagenesis	Mutagenesis	PROPN	NNP	Number=Sing	_	_	_	_
2	of	of	ADP	IN	_	_	_	_	_
3	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
4	activator	activator	NOUN	NN	Number=Sing	_	_	_	_
5	protein	protein	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
6	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
7	1	1	NUM	CD	NumType=Card	_	_	_	_
8	[	[	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
9	AP	ap	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
10	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
11	1	1	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
12	]	]	PUNCT	-RRB-	_	_	_	_	_
13	site	site	NOUN	NN	Number=Sing	_	_	_	_
14	at	at	ADP	IN	_	_	_	_	_
15	-	-	SYM	SYM	_	_	_	_	SpaceAfter=No
16	72	72	NUM	CD	NumType=Card	_	_	_	_
17	abolished	abolish	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
18	basal	basal	ADJ	JJ	Degree=Pos	_	_	_	_
19	promoter	promoter	NOUN	NN	Number=Sing	_	_	_	_
20	activity	activity	NOUN	NN	Number=Sing	_	_	_	_
21	and	and	CCONJ	CC	_	_	_	_	_
22	LPS	Lp	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
23	/	/	PUNCT	,	_	_	_	_	SpaceAfter=No
24	zymosan	zymosan	ADJ	JJ	Degree=Pos	_	_	_	_
25	inducibility	inducibility	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
26	,	,	PUNCT	,	_	_	_	_	_
27	while	while	SCONJ	IN	_	_	_	_	_
28	mutagenesis	mutagenesis	NOUN	NN	Number=Sing	_	_	_	_
29	of	of	ADP	IN	_	_	_	_	_
30	an	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
31	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
32	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
33	kappaB	kappaB	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
34	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
35	like	like	ADJ	JJ	Degree=Pos	_	_	_	_
36	site	site	NOUN	NN	Number=Sing	_	_	_	_
37	at	at	ADP	IN	_	_	_	_	_
38	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
39	20	20	NUM	CD	NumType=Card	_	_	_	_
40	to	to	ADP	IN	_	_	_	_	_
41	-	-	SYM	SYM	_	_	_	_	SpaceAfter=No
42	10	10	NUM	CD	NumType=Card	_	_	_	_
43	had	have	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
44	no	no	DET	DT	_	_	_	_	_
45	effect	effect	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
46	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 837
# text = Nuclear extracts from LPS- and zymosan-treated cells showed strong AP-1 activity by gel-shift analysis, and supershift analysis showed the AP-1 complexes contained specific members of both the jun and fos gene families.
1	Nuclear	nuclear	ADJ	JJ	Degree=Pos	_	_	_	_
2	extracts	extract	NOUN	NNS	Number=Plur	_	_	_	_
3	from	from	ADP	IN	_	_	_	_	_
4	LPS	LPS	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
5	-	-	PUNCT	,	_	_	_	_	_
6	and	and	CCONJ	CC	_	_	_	_	_
7	zymosan	zymosan	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
8	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
9	treated	treat	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
10	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
11	showed	show	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
12	strong	strong	ADJ	JJ	Degree=Pos	_	_	_	_
13	AP	ap	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
14	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
15	1	1	NUM	CD	NumType=Card	_	_	_	_
16	activity	activity	NOUN	NN	Number=Sing	_	_	_	_
17	by	by	ADP	IN	_	_	_	_	_
18	gel	gel	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
19	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
20	shift	shift	NOUN	NN	Number=Sing	_	_	_	_
21	analysis	analysis	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
22	,	,	PUNCT	,	_	_	_	_	_
23	and	and	CCONJ	CC	_	_	_	_	_
24	supershift	supershift	ADJ	JJ	Degree=Pos	_	_	_	_
25	analysis	analysis	NOUN	NN	Number=Sing	_	_	_	_
26	showed	show	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
27	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
28	AP	ap	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
29	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
30	1	1	NUM	CD	NumType=Card	_	_	_	_
31	complexes	complexe	NOUN	NNS	Number=Plur	_	_	_	_
32	contained	contain	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
33	specific	specific	ADJ	JJ	Degree=Pos	_	_	_	_
34	members	member	NOUN	NNS	Number=Plur	_	_	_	_
35	of	of	ADP	IN	_	_	_	_	_
36	both	both	CCONJ	CC	_	_	_	_	_
37	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
38	jun	jun	NOUN	NN	Number=Sing	_	_	_	_
39	and	and	CCONJ	CC	_	_	_	_	_
40	fos	fo	NOUN	NNS	Number=Plur	_	_	_	_
41	gene	gene	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
42	families	family	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
43	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 838
# text = These data indicate that, in contrast to most LPS effects, AP-1, but not nuclear factor-kappaB, mediates LPS induction of collagenase transcription in macrophagelike cells.
1	These	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
2	data	data	NOUN	NN	Number=Sing	_	_	_	_
3	indicate	indicate	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
4	that	that	PRON	DT	Number=Sing|PronType=Dem	_	_	_	SpaceAfter=No
5	,	,	PUNCT	,	_	_	_	_	_
6	in	in	ADP	IN	_	_	_	_	_
7	contrast	contrast	NOUN	NN	Number=Sing	_	_	_	_
8	to	to	ADP	IN	_	_	_	_	_
9	most	most	ADJ	JJS	Degree=Sup	_	_	_	_
10	LPS	Lps	NOUN	NN	Number=Sing	_	_	_	_
11	effects	effect	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
12	,	,	PUNCT	,	_	_	_	_	_
13	AP	ap	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
14	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
15	1	1	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
16	,	,	PUNCT	,	_	_	_	_	_
17	but	but	CCONJ	CC	_	_	_	_	_
18	not	not	ADV	RB	_	_	_	_	_
19	nuclear	nuclear	ADJ	JJ	Degree=Pos	_	_	_	_
20	factor	factor	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
21	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
22	kappaB	kappab	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
23	,	,	PUNCT	,	_	_	_	_	_
24	mediates	mediate	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
25	LPS	Lp	ADJ	JJ	Degree=Pos	_	_	_	_
26	induction	induction	NOUN	NN	Number=Sing	_	_	_	_
27	of	of	ADP	IN	_	_	_	_	_
28	collagenase	collagenase	NOUN	NN	Number=Sing	_	_	_	_
29	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
30	in	in	ADP	IN	_	_	_	_	_
31	macrophagelike	macrophagelike	ADJ	JJ	Degree=Pos	_	_	_	_
32	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
33	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 839
# text = Furthermore, as compared to regulation by phorbol ester, collagenase induction in monocytic cells by cell wall derivatives of bacteria or yeast is largely independent of upstream promoter sequences.
1	Furthermore	furthermore	ADV	RB	_	_	_	_	SpaceAfter=No
2	,	,	PUNCT	,	_	_	_	_	_
3	as	as	SCONJ	IN	_	_	_	_	_
4	compared	compare	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
5	to	to	ADP	IN	_	_	_	_	_
6	regulation	regulation	NOUN	NN	Number=Sing	_	_	_	_
7	by	by	ADP	IN	_	_	_	_	_
8	phorbol	phorbol	NOUN	NN	Number=Sing	_	_	_	_
9	ester	ester	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
10	,	,	PUNCT	,	_	_	_	_	_
11	collagenase	collagenase	NOUN	NN	Number=Sing	_	_	_	_
12	induction	induction	NOUN	NN	Number=Sing	_	_	_	_
13	in	in	ADP	IN	_	_	_	_	_
14	monocytic	monocytic	ADJ	JJ	Degree=Pos	_	_	_	_
15	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
16	by	by	ADP	IN	_	_	_	_	_
17	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
18	wall	wall	NOUN	NN	Number=Sing	_	_	_	_
19	derivatives	derivative	NOUN	NNS	Number=Plur	_	_	_	_
20	of	of	ADP	IN	_	_	_	_	_
21	bacteria	bacteria	NOUN	NN	Number=Sing	_	_	_	_
22	or	or	CCONJ	CC	_	_	_	_	_
23	yeast	yeast	NOUN	NN	Number=Sing	_	_	_	_
24	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
25	largely	largely	ADV	RB	_	_	_	_	_
26	independent	independent	ADJ	JJ	Degree=Pos	_	_	_	_
27	of	of	ADP	IN	_	_	_	_	_
28	upstream	upstream	ADJ	JJ	Degree=Pos	_	_	_	_
29	promoter	promoter	NOUN	NN	Number=Sing	_	_	_	_
30	sequences	sequence	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
31	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 840
# text = Document 003002307 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	003002307	003002307	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 841
# text = Salicylates inhibit lipopolysaccharide-induced transcriptional activation of the tissue factor gene in human monocytic cells.
1	Salicylates	Salicylate	PROPN	NNP	Number=Sing	_	_	_	_
2	inhibit	inhibit	NOUN	NN	Number=Sing	_	_	_	_
3	lipopolysaccharide	lipopolysaccharide	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
4	-	-	PUNCT	:	_	_	_	_	SpaceAfter=No
5	induced	induce	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
6	transcriptional	transcriptional	ADJ	JJ	Degree=Pos	_	_	_	_
7	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
8	of	of	ADP	IN	_	_	_	_	_
9	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
10	tissue	tissue	NOUN	NN	Number=Sing	_	_	_	_
11	factor	factor	NOUN	NN	Number=Sing	_	_	_	_
12	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
13	in	in	ADP	IN	_	_	_	_	_
14	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
15	monocytic	monocytic	ADJ	JJ	Degree=Pos	_	_	_	_
16	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
17	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 842
# text = Binding of plasma Factor VII/VIIa to the tissue factor (TF) receptor initiates the coagulation protease cascades.
1	Binding	binding	NOUN	NN	Number=Sing	_	_	_	_
2	of	of	ADP	IN	_	_	_	_	_
3	plasma	plasma	NOUN	NN	Number=Sing	_	_	_	_
4	Factor	factor	NOUN	NN	Number=Sing	_	_	_	_
5	VII	VII	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
6	/	/	PUNCT	,	_	_	_	_	SpaceAfter=No
7	VIIa	VIIa	PROPN	NNP	Number=Sing	_	_	_	_
8	to	to	ADP	IN	_	_	_	_	_
9	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
10	tissue	tissue	NOUN	NN	Number=Sing	_	_	_	_
11	factor	factor	NOUN	NN	Number=Sing	_	_	_	_
12	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
13	TF	TF	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
14	)	)	PUNCT	-RRB-	_	_	_	_	_
15	receptor	receptor	NOUN	NN	Number=Sing	_	_	_	_
16	initiates	initiate	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
17	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
18	coagulation	coagulation	NOUN	NN	Number=Sing	_	_	_	_
19	protease	protease	NOUN	NN	Number=Sing	_	_	_	_
20	cascades	cascade	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
21	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 843
# text = TF expression by circulating monocytes is associated with thrombotic and inflammatory complications in a variety of diseases.
1	TF	Tf	NOUN	NN	Number=Sing	_	_	_	_
2	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
3	by	by	SCONJ	IN	_	_	_	_	_
4	circulating	circulate	VERB	VBG	VerbForm=Ger	_	_	_	_
5	monocytes	monocyte	NOUN	NNS	Number=Plur	_	_	_	_
6	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
7	associated	associate	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
8	with	with	ADP	IN	_	_	_	_	_
9	thrombotic	thrombotic	ADJ	JJ	Degree=Pos	_	_	_	_
10	and	and	CCONJ	CC	_	_	_	_	_
11	inflammatory	inflammatory	ADJ	JJ	Degree=Pos	_	_	_	_
12	complications	complication	NOUN	NNS	Number=Plur	_	_	_	_
13	in	in	ADP	IN	_	_	_	_	_
14	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
15	variety	variety	NOUN	NN	Number=Sing	_	_	_	_
16	of	of	ADP	IN	_	_	_	_	_
17	diseases	disease	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
18	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 844
# text = Transcriptional activation of the human TF gene in monocytic cells exposed to bacterial lipopolysaccharide (LPS) is mediated by binding of c-Rel/p65 heterodimers to a kappa B site in the TF promoter.
1	Transcriptional	Transcriptional	ADJ	JJ	Degree=Pos	_	_	_	_
2	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
3	of	of	ADP	IN	_	_	_	_	_
4	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
5	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
6	TF	Tf	NOUN	NN	Number=Sing	_	_	_	_
7	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
8	in	in	ADP	IN	_	_	_	_	_
9	monocytic	monocytic	ADJ	JJ	Degree=Pos	_	_	_	_
10	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
11	exposed	expose	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
12	to	to	ADP	IN	_	_	_	_	_
13	bacterial	bacterial	ADJ	JJ	Degree=Pos	_	_	_	_
14	lipopolysaccharide	lipopolysaccharide	NOUN	NN	Number=Sing	_	_	_	_
15	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
16	LPS	LPS	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
17	)	)	PUNCT	-RRB-	_	_	_	_	_
18	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
19	mediated	mediate	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
20	by	by	SCONJ	IN	_	_	_	_	_
21	binding	bind	VERB	VBG	VerbForm=Ger	_	_	_	_
22	of	of	ADP	IN	_	_	_	_	_
23	c	c	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
24	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
25	Rel	Rel	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
26	/	/	PUNCT	,	_	_	_	_	SpaceAfter=No
27	p65	p65	NUM	CD	NumType=Card	_	_	_	_
28	heterodimers	heterodimer	NOUN	NNS	Number=Plur	_	_	_	_
29	to	to	ADP	IN	_	_	_	_	_
30	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
31	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_
32	B	b	NOUN	NN	Number=Sing	_	_	_	_
33	site	site	NOUN	NN	Number=Sing	_	_	_	_
34	in	in	ADP	IN	_	_	_	_	_
35	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
36	TF	TF	PROPN	NNP	Number=Sing	_	_	_	_
37	promoter	promoter	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
38	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 845
# text = Here, we report that a family of anti-inflammatory agents, known as the salicylates, inhibited LPS induction of TF activity and TF gene transcription in human monocytes and monocytic THP-1 cells at clinically relevant doses.
1	Here	here	ADV	RB	PronType=Dem	_	_	_	SpaceAfter=No
2	,	,	PUNCT	,	_	_	_	_	_
3	we	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
4	report	report	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
5	that	that	SCONJ	IN	_	_	_	_	_
6	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
7	family	family	NOUN	NN	Number=Sing	_	_	_	_
8	of	of	ADP	IN	_	_	_	_	_
9	anti-inflammatory	anti-inflammatory	ADJ	JJ	Degree=Pos	_	_	_	_
10	agents	agent	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
11	,	,	PUNCT	,	_	_	_	_	_
12	known	know	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
13	as	as	ADP	IN	_	_	_	_	_
14	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
15	salicylates	salicylate	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
16	,	,	PUNCT	,	_	_	_	_	_
17	inhibited	inhibit	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
18	LPS	LPS	ADJ	JJ	Degree=Pos	_	_	_	_
19	induction	induction	NOUN	NN	Number=Sing	_	_	_	_
20	of	of	ADP	IN	_	_	_	_	_
21	TF	TF	ADJ	JJ	Degree=Pos	_	_	_	_
22	activity	activity	NOUN	NN	Number=Sing	_	_	_	_
23	and	and	CCONJ	CC	_	_	_	_	_
24	TF	Tf	NOUN	NN	Number=Sing	_	_	_	_
25	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
26	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
27	in	in	ADP	IN	_	_	_	_	_
28	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
29	monocytes	monocyte	NOUN	NNS	Number=Plur	_	_	_	_
30	and	and	CCONJ	CC	_	_	_	_	_
31	monocytic	monocytic	ADJ	JJ	Degree=Pos	_	_	_	_
32	THP	Thp	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
33	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
34	1	1	NUM	CD	NumType=Card	_	_	_	_
35	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
36	at	at	ADP	IN	_	_	_	_	_
37	clinically	clinically	ADV	RB	_	_	_	_	_
38	relevant	relevant	ADJ	JJ	Degree=Pos	_	_	_	_
39	doses	dos	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
40	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 846
# text = Furthermore, sodium salicylate blocked the LPS-induced proteolytic degradation of I kappa B alpha, which prevented the nuclear translocation of c-Rel/p65 heterodimers.
1	Furthermore	furthermore	ADV	RB	_	_	_	_	SpaceAfter=No
2	,	,	PUNCT	,	_	_	_	_	_
3	sodium	sodium	ADJ	JJ	Degree=Pos	_	_	_	_
4	salicylate	salicylate	NOUN	NN	Number=Sing	_	_	_	_
5	blocked	block	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
6	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
7	LPS	LPS	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
8	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
9	induced	induce	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
10	proteolytic	proteolytic	ADJ	JJ	Degree=Pos	_	_	_	_
11	degradation	degradation	NOUN	NN	Number=Sing	_	_	_	_
12	of	of	ADP	IN	_	_	_	_	_
13	I	I	PRON	PRP	Case=Nom|Number=Sing|Person=1|PronType=Prs	_	_	_	_
14	kappa	kappa	PROPN	NNP	Number=Sing	_	_	_	_
15	B	B	PROPN	NNP	Number=Sing	_	_	_	_
16	alpha	alpha	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
17	,	,	PUNCT	,	_	_	_	_	_
18	which	which	PRON	WDT	PronType=Rel	_	_	_	_
19	prevented	prevent	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
20	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
21	nuclear	nuclear	ADJ	JJ	Degree=Pos	_	_	_	_
22	translocation	translocation	NOUN	NN	Number=Sing	_	_	_	_
23	of	of	ADP	IN	_	_	_	_	_
24	c	c	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
25	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
26	Rel	Rel	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
27	/	/	PUNCT	,	_	_	_	_	SpaceAfter=No
28	p65	p65	NUM	CD	NumType=Card	_	_	_	_
29	heterodimers	heterodimer	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
30	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 847
# text = In contrast, two other nonsteroidal anti-inflammatory drugs, ibuprofen and indomethacin, did not inhibit LPS induction of the TF gene.
1	In	in	ADP	IN	_	_	_	_	_
2	contrast	contrast	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
3	,	,	PUNCT	,	_	_	_	_	_
4	two	two	NUM	CD	NumType=Card	_	_	_	_
5	other	other	ADJ	JJ	Degree=Pos	_	_	_	_
6	nonsteroidal	nonsteroidal	ADJ	JJ	Degree=Pos	_	_	_	_
7	anti-inflammatory	anti-inflammatory	ADJ	JJ	Degree=Pos	_	_	_	_
8	drugs	drug	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
9	,	,	PUNCT	,	_	_	_	_	_
10	ibuprofen	ibuprofen	ADJ	JJ	Degree=Pos	_	_	_	_
11	and	and	CCONJ	CC	_	_	_	_	_
12	indomethacin	indomethacin	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
13	,	,	PUNCT	,	_	_	_	_	_
14	did	do	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
15	not	not	PART	RB	_	_	_	_	_
16	inhibit	inhibit	VERB	VB	VerbForm=Inf	_	_	_	_
17	LPS	LPS	ADJ	JJ	Degree=Pos	_	_	_	_
18	induction	induction	NOUN	NN	Number=Sing	_	_	_	_
19	of	of	ADP	IN	_	_	_	_	_
20	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
21	TF	TF	PROPN	NNP	Number=Sing	_	_	_	_
22	gene	gene	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
23	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 848
# text = These results indicated that salicylates inhibited LPS induction of TF gene transcription in monocytic cells by preventing nuclear translocation of c-Rel/p65 heterodimers.
1	These	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
2	results	result	NOUN	NNS	Number=Plur	_	_	_	_
3	indicated	indicate	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
4	that	that	SCONJ	IN	_	_	_	_	_
5	salicylates	salicylate	PROPN	NNPS	Number=Plur	_	_	_	_
6	inhibited	inhibit	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
7	LPS	LPS	ADJ	JJ	Degree=Pos	_	_	_	_
8	induction	induction	NOUN	NN	Number=Sing	_	_	_	_
9	of	of	ADP	IN	_	_	_	_	_
10	TF	TF	NOUN	NN	Number=Sing	_	_	_	_
11	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
12	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
13	in	in	ADP	IN	_	_	_	_	_
14	monocytic	monocytic	ADJ	JJ	Degree=Pos	_	_	_	_
15	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
16	by	by	SCONJ	IN	_	_	_	_	_
17	preventing	prevent	VERB	VBG	VerbForm=Ger	_	_	_	_
18	nuclear	nuclear	ADJ	JJ	Degree=Pos	_	_	_	_
19	translocation	translocation	NOUN	NN	Number=Sing	_	_	_	_
20	of	of	ADP	IN	_	_	_	_	_
21	c	c	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
22	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
23	Rel	Rel	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
24	/	/	PUNCT	,	_	_	_	_	SpaceAfter=No
25	p65	p65	NUM	CD	NumType=Card	_	_	_	_
26	heterodimers	heterodimer	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
27	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 849
# text = The clinical benefits of salicylates in the treatment of several diseases, including atherosclerosis and rheumatoid arthritis, may be related to their ability to reduce monocyte gene expression.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	clinical	clinical	ADJ	JJ	Degree=Pos	_	_	_	_
3	benefits	benefit	NOUN	NNS	Number=Plur	_	_	_	_
4	of	of	ADP	IN	_	_	_	_	_
5	salicylates	salicylate	NOUN	NNS	Number=Plur	_	_	_	_
6	in	in	ADP	IN	_	_	_	_	_
7	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
8	treatment	treatment	NOUN	NN	Number=Sing	_	_	_	_
9	of	of	ADP	IN	_	_	_	_	_
10	several	several	ADJ	JJ	Degree=Pos	_	_	_	_
11	diseases	diseasis	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
12	,	,	PUNCT	,	_	_	_	_	_
13	including	include	VERB	VBG	VerbForm=Ger	_	_	_	_
14	atherosclerosis	atherosclerosis	NOUN	NN	Number=Sing	_	_	_	_
15	and	and	CCONJ	CC	_	_	_	_	_
16	rheumatoid	rheumatoid	NOUN	NN	Number=Sing	_	_	_	_
17	arthritis	arthritis	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
18	,	,	PUNCT	,	_	_	_	_	_
19	may	may	AUX	MD	VerbForm=Fin	_	_	_	_
20	be	be	AUX	VB	VerbForm=Inf	_	_	_	_
21	related	related	ADJ	JJ	Degree=Pos	_	_	_	_
22	to	to	ADP	IN	_	_	_	_	_
23	their	they	PRON	PRP$	Number=Plur|Person=3|Poss=Yes|PronType=Prs	_	_	_	_
24	ability	ability	NOUN	NN	Number=Sing	_	_	_	_
25	to	to	PART	TO	_	_	_	_	_
26	reduce	reduce	VERB	VB	VerbForm=Inf	_	_	_	_
27	monocyte	monocyte	NOUN	NN	Number=Sing	_	_	_	_
28	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
29	expression	expression	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
30	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 850
# text = Document 003002314 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	003002314	003002314	NUM	CD	NumType=Card	_	_	_	_
3	ends.	ends.	NOUN	NN	Number=Sing	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 851
# text = CD30-dependent degradation of TRAF2: implications for negative regulation of TRAF signaling and the control of cell survival.
1	CD30	CD30	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
2	-dependent	-dependent	ADJ	JJ	Degree=Pos	_	_	_	_
3	degradation	degradation	NOUN	NN	Number=Sing	_	_	_	_
4	of	of	ADP	IN	_	_	_	_	_
5	TRAF2	TRAF2	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
6	:	:	PUNCT	:	_	_	_	_	_
7	implications	implication	NOUN	NNS	Number=Plur	_	_	_	_
8	for	for	ADP	IN	_	_	_	_	_
9	negative	negative	ADJ	JJ	Degree=Pos	_	_	_	_
10	regulation	regulation	NOUN	NN	Number=Sing	_	_	_	_
11	of	of	ADP	IN	_	_	_	_	_
12	TRAF	Traf	NOUN	NN	Number=Sing	_	_	_	_
13	signaling	signaling	NOUN	NN	Number=Sing	_	_	_	_
14	and	and	CCONJ	CC	_	_	_	_	_
15	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
16	control	control	NOUN	NN	Number=Sing	_	_	_	_
17	of	of	ADP	IN	_	_	_	_	_
18	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
19	survival	survival	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
20	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 852
# text = CD30 is a cell-surface receptor that can augment lymphocyte activation and survival through its ability to induce the transcription factor NF-kappaB.
1	CD30	CD30	PROPN	NNP	Number=Sing	_	_	_	_
2	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
3	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
4	cell	cell	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
5	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
6	surface	surface	NOUN	NN	Number=Sing	_	_	_	_
7	receptor	receptor	NOUN	NN	Number=Sing	_	_	_	_
8	that	that	PRON	WDT	PronType=Rel	_	_	_	_
9	can	can	AUX	MD	VerbForm=Fin	_	_	_	_
10	augment	augment	VERB	VB	VerbForm=Inf	_	_	_	_
11	lymphocyte	lymphocyte	ADJ	JJ	Degree=Pos	_	_	_	_
12	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
13	and	and	CCONJ	CC	_	_	_	_	_
14	survival	survival	NOUN	NN	Number=Sing	_	_	_	_
15	through	through	ADP	IN	_	_	_	_	_
16	its	its	PRON	PRP$	Gender=Neut|Number=Sing|Person=3|Poss=Yes|PronType=Prs	_	_	_	_
17	ability	ability	NOUN	NN	Number=Sing	_	_	_	_
18	to	to	PART	TO	_	_	_	_	_
19	induce	induce	VERB	VB	VerbForm=Inf	_	_	_	_
20	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
21	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
22	factor	factor	NOUN	NN	Number=Sing	_	_	_	_
23	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
24	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
25	kappaB.	kappaB.	PROPN	NNP	Number=Sing	_	_	_	_

# sent_id = 853
# text = CD30, however, has also been implicated in the induction of apoptotic cell death of lymphocytes.
1	CD30	CD30	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
2	,	,	PUNCT	,	_	_	_	_	_
3	however	however	ADV	RB	_	_	_	_	SpaceAfter=No
4	,	,	PUNCT	,	_	_	_	_	_
5	has	have	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
6	also	also	ADV	RB	_	_	_	_	_
7	been	be	AUX	VBN	Tense=Past|VerbForm=Part	_	_	_	_
8	implicated	implicate	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
9	in	in	ADP	IN	_	_	_	_	_
10	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
11	induction	induction	NOUN	NN	Number=Sing	_	_	_	_
12	of	of	ADP	IN	_	_	_	_	_
13	apoptotic	apoptotic	ADJ	JJ	Degree=Pos	_	_	_	_
14	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
15	death	death	NOUN	NN	Number=Sing	_	_	_	_
16	of	of	ADP	IN	_	_	_	_	_
17	lymphocytes	lymphocyte	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
18	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 854
# text = Here we show that one of the effects of CD30 signal transduction is to render cells sensitive to apoptosis induced by the type 1 tumor necrosis factor receptor (TNFR1).
1	Here	here	ADV	RB	PronType=Dem	_	_	_	_
2	we	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
3	show	show	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
4	that	that	SCONJ	IN	_	_	_	_	_
5	one	one	NUM	CD	NumType=Card	_	_	_	_
6	of	of	ADP	IN	_	_	_	_	_
7	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
8	effects	effect	NOUN	NNS	Number=Plur	_	_	_	_
9	of	of	ADP	IN	_	_	_	_	_
10	CD30	CD30	NUM	CD	NumType=Card	_	_	_	_
11	signal	signal	NOUN	NN	Number=Sing	_	_	_	_
12	transduction	transduction	NOUN	NN	Number=Sing	_	_	_	_
13	is	be	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
14	to	to	PART	TO	_	_	_	_	_
15	render	render	VERB	VB	VerbForm=Inf	_	_	_	_
16	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
17	sensitive	sensitive	ADJ	JJ	Degree=Pos	_	_	_	_
18	to	to	ADP	IN	_	_	_	_	_
19	apoptosis	apoptosis	PRON	DT	Number=Sing|PronType=Dem	_	_	_	_
20	induced	induce	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
21	by	by	ADP	IN	_	_	_	_	_
22	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
23	type	type	NOUN	NN	Number=Sing	_	_	_	_
24	1	1	NUM	CD	NumType=Card	_	_	_	_
25	tumor	tumor	NOUN	NN	Number=Sing	_	_	_	_
26	necrosis	necrosis	NOUN	NN	Number=Sing	_	_	_	_
27	factor	factor	NOUN	NN	Number=Sing	_	_	_	_
28	receptor	receptor	NOUN	NN	Number=Sing	_	_	_	_
29	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
30	TNFR1	TNFR1	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
31	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
32	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 855
# text = This sensitization is dependent on the TRAF-binding sites within the CD30 cytoplasmic domain.
1	This	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
2	sensitization	sensitization	NOUN	NN	Number=Sing	_	_	_	_
3	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
4	dependent	dependent	ADJ	JJ	Degree=Pos	_	_	_	_
5	on	on	ADP	IN	_	_	_	_	_
6	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
7	TRAF	Traf	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
8	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
9	binding	binding	VERB	VBG	VerbForm=Ger	_	_	_	_
10	sites	site	NOUN	NNS	Number=Plur	_	_	_	_
11	within	within	ADP	IN	_	_	_	_	_
12	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
13	CD30	CD30	PROPN	NNP	Number=Sing	_	_	_	_
14	cytoplasmic	cytoplasmic	ADJ	JJ	Degree=Pos	_	_	_	_
15	domain	domain	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
16	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 856
# text = One of the proteins that binds to these sites is TRAF2, a signal transduction molecule that is also utilized by TNFR1 to mediate the activation of several downstream kinases and transcription factors.
1	One	one	NUM	CD	NumType=Card	_	_	_	_
2	of	of	ADP	IN	_	_	_	_	_
3	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
4	proteins	protein	NOUN	NNS	Number=Plur	_	_	_	_
5	that	that	PRON	WDT	PronType=Rel	_	_	_	_
6	binds	bind	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
7	to	to	ADP	IN	_	_	_	_	_
8	these	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
9	sites	site	NOUN	NNS	Number=Plur	_	_	_	_
10	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
11	TRAF2	TRAF2	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
12	,	,	PUNCT	,	_	_	_	_	_
13	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
14	signal	signal	NOUN	NN	Number=Sing	_	_	_	_
15	transduction	transduction	NOUN	NN	Number=Sing	_	_	_	_
16	molecule	molecule	NOUN	NN	Number=Sing	_	_	_	_
17	that	that	PRON	WDT	PronType=Rel	_	_	_	_
18	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
19	also	also	ADV	RB	_	_	_	_	_
20	utilized	utilize	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
21	by	by	ADP	IN	_	_	_	_	_
22	TNFR1	tNFR1	PROPN	NNP	Number=Sing	_	_	_	_
23	to	to	PART	TO	_	_	_	_	_
24	mediate	mediate	VERB	VB	VerbForm=Inf	_	_	_	_
25	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
26	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
27	of	of	ADP	IN	_	_	_	_	_
28	several	several	ADJ	JJ	Degree=Pos	_	_	_	_
29	downstream	downstream	ADJ	JJ	Degree=Pos	_	_	_	_
30	kinases	kinase	NOUN	NNS	Number=Plur	_	_	_	_
31	and	and	CCONJ	CC	_	_	_	_	_
32	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
33	factors	factor	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
34	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 857
# text = During CD30 signal transduction, we found that binding of TRAF2 to the cytoplasmic domain of CD30 results in the rapid depletion of TRAF2 and the associated protein TRAF1 by proteolysis.
1	During	during	ADP	IN	_	_	_	_	_
2	CD30	CD30	NUM	CD	NumType=Card	_	_	_	_
3	signal	signal	NOUN	NN	Number=Sing	_	_	_	_
4	transduction	transduction	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
5	,	,	PUNCT	,	_	_	_	_	_
6	we	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
7	found	find	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
8	that	that	SCONJ	IN	_	_	_	_	_
9	binding	bind	VERB	VBG	VerbForm=Ger	_	_	_	_
10	of	of	ADP	IN	_	_	_	_	_
11	TRAF2	Traf2	NUM	CD	NumType=Card	_	_	_	_
12	to	to	ADP	IN	_	_	_	_	_
13	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
14	cytoplasmic	cytoplasmic	ADJ	JJ	Degree=Pos	_	_	_	_
15	domain	domain	NOUN	NN	Number=Sing	_	_	_	_
16	of	of	ADP	IN	_	_	_	_	_
17	CD30	CD30	NUM	CD	NumType=Card	_	_	_	_
18	results	result	NOUN	NNS	Number=Plur	_	_	_	_
19	in	in	ADP	IN	_	_	_	_	_
20	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
21	rapid	rapid	ADJ	JJ	Degree=Pos	_	_	_	_
22	depletion	depletion	NOUN	NN	Number=Sing	_	_	_	_
23	of	of	ADP	IN	_	_	_	_	_
24	TRAF2	TRAF2	NUM	CD	NumType=Card	_	_	_	_
25	and	and	CCONJ	CC	_	_	_	_	_
26	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
27	associated	associate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
28	protein	protein	NOUN	NN	Number=Sing	_	_	_	_
29	TRAF1	tRAF1	NUM	CD	NumType=Card	_	_	_	_
30	by	by	ADP	IN	_	_	_	_	_
31	proteolysis	proteolysis	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
32	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 858
# text = These data suggest a model in which CD30 limits its own ability to transduce cell survival signals through signal-coupled depletion of TRAF2.
1	These	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
2	data	data	NOUN	NN	Number=Sing	_	_	_	_
3	suggest	suggest	VERB	VB	VerbForm=Inf	_	_	_	_
4	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
5	model	model	NOUN	NN	Number=Sing	_	_	_	_
6	in	in	ADP	IN	_	_	_	_	_
7	which	which	PRON	WDT	PronType=Rel	_	_	_	_
8	CD30	CD30	PROPN	NNP	Number=Sing	_	_	_	_
9	limits	limit	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
10	its	its	PRON	PRP$	Gender=Neut|Number=Sing|Person=3|Poss=Yes|PronType=Prs	_	_	_	_
11	own	own	ADJ	JJ	Degree=Pos	_	_	_	_
12	ability	ability	NOUN	NN	Number=Sing	_	_	_	_
13	to	to	PART	TO	_	_	_	_	_
14	transduce	transduce	VERB	VB	VerbForm=Inf	_	_	_	_
15	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
16	survival	survival	NOUN	NN	Number=Sing	_	_	_	_
17	signals	signal	NOUN	NNS	Number=Plur	_	_	_	_
18	through	through	ADP	IN	_	_	_	_	_
19	signal	signal	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
20	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
21	coupled	coupl	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
22	depletion	depletion	NOUN	NN	Number=Sing	_	_	_	_
23	of	of	ADP	IN	_	_	_	_	_
24	TRAF2	TRAF2	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
25	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 859
# text = Depletion of intracellular TRAF2 and its coassociated proteins also increased the sensitivity of the cell to undergoing apoptosis during activation of death-inducing receptors such as TNFR1.
1	Depletion	Depletion	NOUN	NN	Number=Sing	_	_	_	_
2	of	of	ADP	IN	_	_	_	_	_
3	intracellular	intracellular	ADJ	JJ	Degree=Pos	_	_	_	_
4	TRAF2	Traf2	NOUN	NN	Number=Sing	_	_	_	_
5	and	and	CCONJ	CC	_	_	_	_	_
6	its	its	PRON	PRP$	Gender=Neut|Number=Sing|Person=3|Poss=Yes|PronType=Prs	_	_	_	_
7	coassociated	coassociate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
8	proteins	protein	NOUN	NNS	Number=Plur	_	_	_	_
9	also	also	ADV	RB	_	_	_	_	_
10	increased	increase	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
11	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
12	sensitivity	sensitivity	NOUN	NN	Number=Sing	_	_	_	_
13	of	of	ADP	IN	_	_	_	_	_
14	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
15	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
16	to	to	ADP	IN	_	_	_	_	_
17	undergoing	undergoing	ADJ	JJ	Degree=Pos	_	_	_	_
18	apoptosis	apoptosis	NOUN	NN	Number=Sing	_	_	_	_
19	during	during	ADP	IN	_	_	_	_	_
20	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
21	of	of	ADP	IN	_	_	_	_	_
22	death	death	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
23	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
24	inducing	induce	VERB	VBG	VerbForm=Ger	_	_	_	_
25	receptors	receptor	NOUN	NNS	Number=Plur	_	_	_	_
26	such	such	ADJ	JJ	Degree=Pos	_	_	_	_
27	as	as	ADP	IN	_	_	_	_	_
28	TNFR1	TNFR1	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
29	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 860
# text = Consistent with this hypothesis, expression of a dominant-negative form of TRAF2 was found to potentiate TNFR1-mediated death.
1	Consistent	consistent	ADJ	JJ	Degree=Pos	_	_	_	_
2	with	with	ADP	IN	_	_	_	_	_
3	this	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
4	hypothesis	hypothesis	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
5	,	,	PUNCT	,	_	_	_	_	_
6	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
7	of	of	ADP	IN	_	_	_	_	_
8	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
9	dominant	dominant	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
10	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
11	negative	negative	ADJ	JJ	Degree=Pos	_	_	_	_
12	form	form	NOUN	NN	Number=Sing	_	_	_	_
13	of	of	ADP	IN	_	_	_	_	_
14	TRAF2	TRAF2	NOUN	NN	Number=Sing	_	_	_	_
15	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
16	found	find	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
17	to	to	PART	TO	_	_	_	_	_
18	potentiate	potentiate	VERB	VB	VerbForm=Inf	_	_	_	_
19	TNFR1	tNFR1	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
20	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
21	mediated	mediate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
22	death	death	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
23	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 861
# text = These studies provide a potential mechanism through which CD30, as well as other TRAF-binding members of the TNFR superfamily, can negatively regulate cell survival.
1	These	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
2	studies	study	NOUN	NNS	Number=Plur	_	_	_	_
3	provide	provide	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
4	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
5	potential	potential	NOUN	NN	Number=Sing	_	_	_	_
6	mechanism	mechanism	NOUN	NN	Number=Sing	_	_	_	_
7	through	through	ADP	IN	_	_	_	_	_
8	which	which	PRON	WDT	PronType=Rel	_	_	_	_
9	CD30	CD30	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
10	,	,	PUNCT	,	_	_	_	_	_
11	as	as	ADV	RB	_	_	_	_	_
12	well	well	ADV	RB	Degree=Pos	_	_	_	_
13	as	as	ADP	IN	_	_	_	_	_
14	other	other	ADJ	JJ	Degree=Pos	_	_	_	_
15	TRAF	Traf	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
16	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
17	binding	binding	VERB	VBG	VerbForm=Ger	_	_	_	_
18	members	member	NOUN	NNS	Number=Plur	_	_	_	_
19	of	of	ADP	IN	_	_	_	_	_
20	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
21	TNFR	TNFR	PROPN	NNP	Number=Sing	_	_	_	_
22	superfamily	superfamily	ADV	RB	_	_	_	_	SpaceAfter=No
23	,	,	PUNCT	,	_	_	_	_	_
24	can	can	AUX	MD	VerbForm=Fin	_	_	_	_
25	negatively	negatively	ADV	RB	_	_	_	_	_
26	regulate	regulate	VERB	VB	VerbForm=Inf	_	_	_	_
27	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
28	survival	survival	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
29	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 862
# text = Document 003002320 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	003002320	003002320	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 863
# text = Calcineurin acts in synergy with PMA to inactivate I kappa B/MAD3, an inhibitor of NF-kappa B.
1	Calcineurin	Calcineurin	VERB	VB	Mood=Imp|VerbForm=Fin	_	_	_	_
2	acts	act	NOUN	NNS	Number=Plur	_	_	_	_
3	in	in	ADP	IN	_	_	_	_	_
4	synergy	synergy	NOUN	NN	Number=Sing	_	_	_	_
5	with	with	ADP	IN	_	_	_	_	_
6	PMA	PMA	PROPN	NNP	Number=Sing	_	_	_	_
7	to	to	PART	TO	_	_	_	_	_
8	inactivate	inactivate	VERB	VB	VerbForm=Inf	_	_	_	_
9	I	I	PRON	PRP	Case=Nom|Number=Sing|Person=1|PronType=Prs	_	_	_	_
10	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_
11	B/	B/	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
12	MAD3	MAD3	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
13	,	,	PUNCT	,	_	_	_	_	_
14	an	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
15	inhibitor	inhibitor	NOUN	NN	Number=Sing	_	_	_	_
16	of	of	ADP	IN	_	_	_	_	_
17	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
18	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
19	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_
20	B	b	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
21	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 864
# text = The interleukin-2 (IL-2) promoter consists of several independent T cell receptor (TcR) responsive elements.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	interleukin	interleukin	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
3	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
4	2	2	NUM	CD	NumType=Card	_	_	_	_
5	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
6	IL	Il	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
7	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
8	2	2	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
9	)	)	PUNCT	-RRB-	_	_	_	_	_
10	promoter	promoter	NOUN	NN	Number=Sing	_	_	_	_
11	consists	consist	NOUN	NNS	Number=Plur	_	_	_	_
12	of	of	ADP	IN	_	_	_	_	_
13	several	several	ADJ	JJ	Degree=Pos	_	_	_	_
14	independent	independent	ADJ	JJ	Degree=Pos	_	_	_	_
15	T	t	PROPN	NNP	Number=Sing	_	_	_	_
16	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
17	receptor	receptor	NOUN	NN	Number=Sing	_	_	_	_
18	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
19	TcR	TcR	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
20	)	)	PUNCT	-RRB-	_	_	_	_	_
21	responsive	responsive	ADJ	JJ	Degree=Pos	_	_	_	_
22	elements	element	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
23	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 865
# text = The induction of promoters dependent on these elements is inhibitable by the immunosuppressants cyclosporin A (CsA) and tacrolimus (FK-506).
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	induction	induction	NOUN	NN	Number=Sing	_	_	_	_
3	of	of	ADP	IN	_	_	_	_	_
4	promoters	promoter	NOUN	NNS	Number=Plur	_	_	_	_
5	dependent	dependent	ADJ	JJ	Degree=Pos	_	_	_	_
6	on	on	ADP	IN	_	_	_	_	_
7	these	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
8	elements	element	NOUN	NNS	Number=Plur	_	_	_	_
9	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
10	inhibitable	inhibitable	ADJ	JJ	Degree=Pos	_	_	_	_
11	by	by	ADP	IN	_	_	_	_	_
12	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
13	immunosuppressants	immunosuppressant	NOUN	NNS	Number=Plur	_	_	_	_
14	cyclosporin	cyclosporin	NOUN	NN	Number=Sing	_	_	_	_
15	A	A	PROPN	NNP	Number=Sing	_	_	_	_
16	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
17	CsA	csa	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
18	)	)	PUNCT	-RRB-	_	_	_	_	_
19	and	and	CCONJ	CC	_	_	_	_	_
20	tacrolimus	tacrolimus	NOUN	NN	Number=Sing	_	_	_	_
21	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
22	FK	FK	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
23	-	-	SYM	SYM	_	_	_	_	SpaceAfter=No
24	506	506	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
25	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
26	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 866
# text = Calcineurin, a Ca2+/calmodulin-dependent protein phosphatase, is the FK-506- and CsA-sensitive enzyme required for TcR mediated activation of the IL-2 promoter.
1	Calcineurin	Calcineurin	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
2	,	,	PUNCT	,	_	_	_	_	_
3	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
4	Ca2+/calmodulin	Ca2+/calmodulin	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
5	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
6	dependent	dependent	ADJ	JJ	Degree=Pos	_	_	_	_
7	protein	protein	NOUN	NN	Number=Sing	_	_	_	_
8	phosphatase	phosphatase	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
9	,	,	PUNCT	,	_	_	_	_	_
10	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
11	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
12	FK	FK	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
13	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
14	506	506	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
15	-	-	PUNCT	HYPH	_	_	_	_	_
16	and	and	CCONJ	CC	_	_	_	_	_
17	CsA	csa	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
18	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
19	sensitive	sensitive	ADJ	JJ	Degree=Pos	_	_	_	_
20	enzyme	enzyme	NOUN	NN	Number=Sing	_	_	_	_
21	required	require	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
22	for	for	ADP	IN	_	_	_	_	_
23	TcR	TcR	PROPN	NNP	Number=Sing	_	_	_	_
24	mediated	mediate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
25	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
26	of	of	ADP	IN	_	_	_	_	_
27	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
28	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
29	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
30	2	2	NUM	CD	NumType=Card	_	_	_	_
31	promoter	promoter	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
32	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 867
# text = We report that a constitutively active form of calcineurin partially substitutes for the Ca2+ co-stimulus required to activate the IL-2 promoter elements IL-2A (which binds the factors OAP and Oct-1) and IL-2E (which binds NF-AT), and completely substitutes for the Ca2+ co-stimulus required to stimulate an NF-kappa B-dependent element.
1	We	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
2	report	report	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
3	that	that	PRON	DT	Number=Sing|PronType=Dem	_	_	_	_
4	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
5	constitutively	constitutively	ADV	RB	_	_	_	_	_
6	active	active	ADJ	JJ	Degree=Pos	_	_	_	_
7	form	form	NOUN	NN	Number=Sing	_	_	_	_
8	of	of	ADP	IN	_	_	_	_	_
9	calcineurin	calcineurin	NOUN	NN	Number=Sing	_	_	_	_
10	partially	partially	ADV	RB	_	_	_	_	_
11	substitutes	substitute	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
12	for	for	ADP	IN	_	_	_	_	_
13	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
14	Ca2	ca2	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
15	+	+	SYM	SYM	_	_	_	_	_
16	co-stimulus	co-stimulus	NOUN	NN	Number=Sing	_	_	_	_
17	required	require	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
18	to	to	PART	TO	_	_	_	_	_
19	activate	activate	VERB	VB	VerbForm=Inf	_	_	_	_
20	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
21	IL	Il	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
22	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
23	2	2	NUM	CD	NumType=Card	_	_	_	_
24	promoter	promoter	NOUN	NN	Number=Sing	_	_	_	_
25	elements	element	NOUN	NNS	Number=Plur	_	_	_	_
26	IL	Il	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
27	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
28	2	2	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
29	A	a	NOUN	NN	Number=Sing	_	_	_	_
30	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
31	which	which	PRON	WDT	PronType=Rel	_	_	_	_
32	binds	bind	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
33	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
34	factors	factor	NOUN	NNS	Number=Plur	_	_	_	_
35	OAP	OAP	PROPN	NNP	Number=Sing	_	_	_	_
36	and	and	CCONJ	CC	_	_	_	_	_
37	Oct	Oct	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
38	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
39	1	1	X	LS	_	_	_	_	SpaceAfter=No
40	)	)	PUNCT	-RRB-	_	_	_	_	_
41	and	and	CCONJ	CC	_	_	_	_	_
42	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
43	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
44	2E	2E	PROPN	NNP	Number=Sing	_	_	_	_
45	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
46	which	which	PRON	WDT	PronType=Int	_	_	_	_
47	binds	bind	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
48	NF	Nf	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
49	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
50	AT	at	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
51	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
52	,	,	PUNCT	,	_	_	_	_	_
53	and	and	CCONJ	CC	_	_	_	_	_
54	completely	completely	ADV	RB	_	_	_	_	_
55	substitutes	substitute	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
56	for	for	ADP	IN	_	_	_	_	_
57	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
58	Ca2	ca2	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
59	+	+	SYM	SYM	_	_	_	_	_
60	co-stimulus	co-stimulus	NOUN	NN	Number=Sing	_	_	_	_
61	required	require	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
62	to	to	PART	TO	_	_	_	_	_
63	stimulate	stimulate	VERB	VB	VerbForm=Inf	_	_	_	_
64	an	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
65	NF	Nf	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
66	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
67	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_
68	B	b	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
69	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
70	dependent	dependent	ADJ	JJ	Degree=Pos	_	_	_	_
71	element	element	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
72	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 868
# text = Calcineurin stimulates the NF-kappa B element by enhancing inactivation of I kappa B/MAD3, an inhibitor of NF-kappa B, thereby increasing the amount of nuclear NF-kappa B DNA binding activity.
1	Calcineurin	Calcineurin	PROPN	NNP	Number=Sing	_	_	_	_
2	stimulates	stimulate	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
3	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
4	NF	Nf	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
5	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
6	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_
7	B	b	NOUN	NN	Number=Sing	_	_	_	_
8	element	element	NOUN	NN	Number=Sing	_	_	_	_
9	by	by	SCONJ	IN	_	_	_	_	_
10	enhancing	enhance	VERB	VBG	VerbForm=Ger	_	_	_	_
11	inactivation	inactivation	NOUN	NN	Number=Sing	_	_	_	_
12	of	of	ADP	IN	_	_	_	_	_
13	I	I	PRON	PRP	Case=Nom|Number=Sing|Person=1|PronType=Prs	_	_	_	_
14	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_
15	B/	B/	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
16	MAD3	MAD3	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
17	,	,	PUNCT	,	_	_	_	_	_
18	an	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
19	inhibitor	inhibitor	NOUN	NN	Number=Sing	_	_	_	_
20	of	of	ADP	IN	_	_	_	_	_
21	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
22	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
23	kappa	kappa	PROPN	NNP	Number=Sing	_	_	_	_
24	B	b	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
25	,	,	PUNCT	,	_	_	_	_	_
26	thereby	thereby	ADV	RB	_	_	_	_	_
27	increasing	increase	VERB	VBG	VerbForm=Ger	_	_	_	_
28	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
29	amount	amount	NOUN	NN	Number=Sing	_	_	_	_
30	of	of	ADP	IN	_	_	_	_	_
31	nuclear	nuclear	ADJ	JJ	Degree=Pos	_	_	_	_
32	NF	NF	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
33	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
34	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_
35	B	b	NOUN	NN	Number=Sing	_	_	_	_
36	DNA	dna	NOUN	NN	Number=Sing	_	_	_	_
37	binding	binde	VERB	VBG	VerbForm=Ger	_	_	_	_
38	activity	activity	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
39	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 869
# text = These data provide the first demonstration in vivo that activation of a protein phosphatase can inactivate I kappa B, and suggest one possible explanation for mechanism-based toxicities associated with FK-506 and CsA by demonstrating that these drugs can inhibit the calcineurin-dependent activation of a virtually ubiquitous transcription factor.
1	These	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
2	data	data	NOUN	NN	Number=Sing	_	_	_	_
3	provide	provide	VERB	VB	VerbForm=Inf	_	_	_	_
4	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
5	first	first	ADJ	JJ	Degree=Pos|NumType=Ord	_	_	_	_
6	demonstration	demonstration	NOUN	NN	Number=Sing	_	_	_	_
7	in	in	ADP	IN	_	_	_	_	_
8	vivo	vivo	NOUN	NN	Number=Sing	_	_	_	_
9	that	that	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
10	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
11	of	of	ADP	IN	_	_	_	_	_
12	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
13	protein	protein	NOUN	NN	Number=Sing	_	_	_	_
14	phosphatase	phosphatase	NOUN	NN	Number=Sing	_	_	_	_
15	can	can	AUX	MD	VerbForm=Fin	_	_	_	_
16	inactivate	inactivate	VERB	VB	VerbForm=Inf	_	_	_	_
17	I	I	PRON	PRP	Case=Nom|Number=Sing|Person=1|PronType=Prs	_	_	_	_
18	kappa	kappa	PROPN	NNP	Number=Sing	_	_	_	_
19	B	b	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
20	,	,	PUNCT	,	_	_	_	_	_
21	and	and	CCONJ	CC	_	_	_	_	_
22	suggest	suggest	VERB	VB	VerbForm=Inf	_	_	_	_
23	one	one	NUM	CD	NumType=Card	_	_	_	_
24	possible	possible	ADJ	JJ	Degree=Pos	_	_	_	_
25	explanation	explanation	NOUN	NN	Number=Sing	_	_	_	_
26	for	for	ADP	IN	_	_	_	_	_
27	mechanism	mechanism	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
28	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
29	based	base	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
30	toxicities	toxicity	NOUN	NNS	Number=Plur	_	_	_	_
31	associated	associate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
32	with	with	ADP	IN	_	_	_	_	_
33	FK	FK	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
34	-	-	SYM	SYM	_	_	_	_	SpaceAfter=No
35	506	506	NUM	CD	NumType=Card	_	_	_	_
36	and	and	CCONJ	CC	_	_	_	_	_
37	CsA	csa	PROPN	NNP	Number=Sing	_	_	_	_
38	by	by	SCONJ	IN	_	_	_	_	_
39	demonstrating	demonstrat	VERB	VBG	VerbForm=Ger	_	_	_	_
40	that	that	SCONJ	IN	_	_	_	_	_
41	these	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
42	drugs	drug	NOUN	NNS	Number=Plur	_	_	_	_
43	can	can	AUX	MD	VerbForm=Fin	_	_	_	_
44	inhibit	inhibit	VERB	VB	VerbForm=Inf	_	_	_	_
45	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
46	calcineurin	calcineurin	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
47	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
48	dependent	dependent	ADJ	JJ	Degree=Pos	_	_	_	_
49	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
50	of	of	ADP	IN	_	_	_	_	_
51	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
52	virtually	virtually	ADV	RB	_	_	_	_	_
53	ubiquitous	ubiquitous	ADJ	JJ	Degree=Pos	_	_	_	_
54	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
55	factor	factor	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
56	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 870
# text = Document 003002321 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	003002321	003002321	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 871
# text = Active suppression of the class II transactivator-encoding AIR-1 locus is responsible for the lack of major histocompatibility complex class II gene expression observed during differentiation from B cells to plasma cells.
1	Active	active	ADJ	JJ	Degree=Pos	_	_	_	_
2	suppression	suppression	NOUN	NN	Number=Sing	_	_	_	_
3	of	of	ADP	IN	_	_	_	_	_
4	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
5	class	class	NOUN	NN	Number=Sing	_	_	_	_
6	II	ii	NUM	CD	NumType=Card	_	_	_	_
7	transactivator	transactivator	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
8	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
9	encoding	encod	VERB	VBG	VerbForm=Ger	_	_	_	_
10	AIR	AIR	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
11	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
12	1	1	NUM	CD	NumType=Card	_	_	_	_
13	locus	locus	NOUN	NN	Number=Sing	_	_	_	_
14	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
15	responsible	responsible	ADJ	JJ	Degree=Pos	_	_	_	_
16	for	for	ADP	IN	_	_	_	_	_
17	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
18	lack	lack	NOUN	NN	Number=Sing	_	_	_	_
19	of	of	ADP	IN	_	_	_	_	_
20	major	major	ADJ	JJ	Degree=Pos	_	_	_	_
21	histocompatibility	histocompatibility	NOUN	NN	Number=Sing	_	_	_	_
22	complex	complex	NOUN	NN	Number=Sing	_	_	_	_
23	class	class	NOUN	NN	Number=Sing	_	_	_	_
24	II	ii	NUM	CD	NumType=Card	_	_	_	_
25	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
26	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
27	observed	observe	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
28	during	during	ADP	IN	_	_	_	_	_
29	differentiation	differentiation	NOUN	NN	Number=Sing	_	_	_	_
30	from	from	ADP	IN	_	_	_	_	_
31	B	b	ADJ	JJ	Degree=Pos	_	_	_	_
32	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
33	to	to	ADP	IN	_	_	_	_	_
34	plasma	plasma	NOUN	NN	Number=Sing	_	_	_	_
35	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
36	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 872
# text = In this study the genetic control of major histocompatibility complex (MHC) class II gene expression during the transition from B cell to plasma cell has been analyzed.
1	In	in	ADP	IN	_	_	_	_	_
2	this	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
3	study	study	NOUN	NN	Number=Sing	_	_	_	_
4	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
5	genetic	genetic	ADJ	JJ	Degree=Pos	_	_	_	_
6	control	control	NOUN	NN	Number=Sing	_	_	_	_
7	of	of	ADP	IN	_	_	_	_	_
8	major	major	ADJ	JJ	Degree=Pos	_	_	_	_
9	histocompatibility	histocompatibility	NOUN	NN	Number=Sing	_	_	_	_
10	complex	complex	NOUN	NN	Number=Sing	_	_	_	_
11	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
12	MHC	MHC	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
13	)	)	PUNCT	-RRB-	_	_	_	_	_
14	class	class	NOUN	NN	Number=Sing	_	_	_	_
15	II	ii	NUM	CD	NumType=Card	_	_	_	_
16	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
17	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
18	during	during	ADP	IN	_	_	_	_	_
19	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
20	transition	transition	NOUN	NN	Number=Sing	_	_	_	_
21	from	from	ADP	IN	_	_	_	_	_
22	B	b	NOUN	NN	Number=Sing	_	_	_	_
23	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
24	to	to	ADP	IN	_	_	_	_	_
25	plasma	plasma	NOUN	NN	Number=Sing	_	_	_	_
26	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
27	has	have	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
28	been	be	AUX	VBN	Tense=Past|VerbForm=Part	_	_	_	_
29	analyzed	analyze	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	SpaceAfter=No
30	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 873
# text = Class II molecules are not expressed in plasma cells because of an active suppression resulting in the abrogation of class II gene transcription.
1	Class	class	VERB	VB	Mood=Imp|VerbForm=Fin	_	_	_	_
2	II	ii	NUM	CD	NumType=Card	_	_	_	_
3	molecules	molecule	NOUN	NNS	Number=Plur	_	_	_	_
4	are	be	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
5	not	not	PART	RB	_	_	_	_	_
6	expressed	express	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
7	in	in	ADP	IN	_	_	_	_	_
8	plasma	plasma	NOUN	NN	Number=Sing	_	_	_	_
9	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
10	because	because	ADP	IN	_	_	_	_	_
11	of	of	ADP	IN	_	_	_	_	_
12	an	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
13	active	active	ADJ	JJ	Degree=Pos	_	_	_	_
14	suppression	suppression	NOUN	NN	Number=Sing	_	_	_	_
15	resulting	result	VERB	VBG	VerbForm=Ger	_	_	_	_
16	in	in	ADP	IN	_	_	_	_	_
17	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
18	abrogation	abrogation	NOUN	NN	Number=Sing	_	_	_	_
19	of	of	ADP	IN	_	_	_	_	_
20	class	class	NOUN	NN	Number=Sing	_	_	_	_
21	II	ii	NUM	CD	NumType=Card	_	_	_	_
22	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
23	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
24	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 874
# text = We show here that the plasma cell-specific repressor function, designated SIR (suppressor of immune response genes), does not act directly on the transcription of class II genes, but instead on the transcription of the AIR-1 gene, whose product, the class II transactivator (CIITA), is fundamental for the regulation of the constitutive and inducible expression of MHC class II genes.
1	We	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
2	show	show	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
3	here	here	ADV	RB	PronType=Dem	_	_	_	_
4	that	that	SCONJ	IN	_	_	_	_	_
5	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
6	plasma	plasma	NOUN	NN	Number=Sing	_	_	_	_
7	cell	cell	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
8	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
9	specific	specific	ADJ	JJ	Degree=Pos	_	_	_	_
10	repressor	repressor	NOUN	NN	Number=Sing	_	_	_	_
11	function	function	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
12	,	,	PUNCT	,	_	_	_	_	_
13	designated	designate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
14	SIR	Sir	NOUN	NN	Number=Sing	_	_	_	_
15	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
16	suppressor	suppressor	NOUN	NN	Number=Sing	_	_	_	_
17	of	of	ADP	IN	_	_	_	_	_
18	immune	immune	ADJ	JJ	Degree=Pos	_	_	_	_
19	response	response	NOUN	NN	Number=Sing	_	_	_	_
20	genes	gene	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
21	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
22	,	,	PUNCT	,	_	_	_	_	_
23	does	do	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
24	not	not	PART	RB	_	_	_	_	_
25	act	act	VERB	VB	VerbForm=Inf	_	_	_	_
26	directly	directly	ADV	RB	_	_	_	_	_
27	on	on	ADP	IN	_	_	_	_	_
28	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
29	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
30	of	of	ADP	IN	_	_	_	_	_
31	class	class	NOUN	NN	Number=Sing	_	_	_	_
32	II	ii	NUM	CD	NumType=Card	_	_	_	_
33	genes	gene	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
34	,	,	PUNCT	,	_	_	_	_	_
35	but	but	CCONJ	CC	_	_	_	_	_
36	instead	instead	ADV	RB	_	_	_	_	_
37	on	on	ADP	IN	_	_	_	_	_
38	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
39	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
40	of	of	ADP	IN	_	_	_	_	_
41	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
42	AIR	Air	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
43	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
44	1	1	NUM	CD	NumType=Card	_	_	_	_
45	gene	gene	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
46	,	,	PUNCT	,	_	_	_	_	_
47	whose	whose	PRON	WP$	Poss=Yes|PronType=Int	_	_	_	_
48	product	product	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
49	,	,	PUNCT	,	_	_	_	_	_
50	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
51	class	class	NOUN	NN	Number=Sing	_	_	_	_
52	II	ii	NUM	CD	NumType=Card	_	_	_	_
53	transactivator	transactivator	NOUN	NN	Number=Sing	_	_	_	_
54	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
55	CIITA	CIITA	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
56	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
57	,	,	PUNCT	,	_	_	_	_	_
58	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
59	fundamental	fundamental	ADJ	JJ	Degree=Pos	_	_	_	_
60	for	for	ADP	IN	_	_	_	_	_
61	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
62	regulation	regulation	NOUN	NN	Number=Sing	_	_	_	_
63	of	of	ADP	IN	_	_	_	_	_
64	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
65	constitutive	constitutive	ADJ	JJ	Degree=Pos	_	_	_	_
66	and	and	CCONJ	CC	_	_	_	_	_
67	inducible	inducible	ADJ	JJ	Degree=Pos	_	_	_	_
68	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
69	of	of	ADP	IN	_	_	_	_	_
70	MHC	MHC	PROPN	NNP	Number=Sing	_	_	_	_
71	class	class	NOUN	NN	Number=Sing	_	_	_	_
72	II	ii	NUM	CD	NumType=Card	_	_	_	_
73	genes	gene	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
74	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 875
# text = This was unambiguously demonstrated by the fact that plasmacytoma x B cell hybrids carrying an AIR-1 locus derived from CIITA-expressing cells do not express CIITA-specific transcripts.
1	This	this	PRON	DT	Number=Sing|PronType=Dem	_	_	_	_
2	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
3	unambiguously	unambiguously	ADV	RB	_	_	_	_	_
4	demonstrated	demonstrate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
5	by	by	ADP	IN	_	_	_	_	_
6	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
7	fact	fact	NOUN	NN	Number=Sing	_	_	_	_
8	that	that	SCONJ	IN	_	_	_	_	_
9	plasmacytoma	plasmacytoma	NOUN	NN	Number=Sing	_	_	_	_
10	x	x	SYM	SYM	_	_	_	_	_
11	B	b	ADJ	JJ	Degree=Pos	_	_	_	_
12	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
13	hybrids	hybrid	NOUN	NNS	Number=Plur	_	_	_	_
14	carrying	carry	VERB	VBG	VerbForm=Ger	_	_	_	_
15	an	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
16	AIR	AIR	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
17	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
18	1	1	NUM	CD	NumType=Card	_	_	_	_
19	locus	locus	NOUN	NN	Number=Sing	_	_	_	_
20	derived	derive	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
21	from	from	ADP	IN	_	_	_	_	_
22	CIITA	CIITA	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
23	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
24	expressing	expresse	ADJ	JJ	Degree=Pos	_	_	_	_
25	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
26	do	do	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
27	not	not	PART	RB	_	_	_	_	_
28	express	express	VERB	VB	VerbForm=Inf	_	_	_	_
29	CIITA	CIITa	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
30	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
31	specific	specific	ADJ	JJ	Degree=Pos	_	_	_	_
32	transcripts	transcript	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
33	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 876
# text = Transfection of a cDNA containing the human CIITA coding sequence under the control of an heterologous promoter restores expression of human MHC class II genes in the hybrids and is responsible for de novo expression of mouse MHC class II genes in both the mouse plasmacytoma cell line and the hybrids.
1	Transfection	Transfection	NOUN	NN	Number=Sing	_	_	_	_
2	of	of	ADP	IN	_	_	_	_	_
3	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
4	cDNA	cDNa	NOUN	NN	Number=Sing	_	_	_	_
5	containing	contain	VERB	VBG	VerbForm=Ger	_	_	_	_
6	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
7	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
8	CIITA	CIITa	NOUN	NN	Number=Sing	_	_	_	_
9	coding	code	NOUN	NN	Number=Sing	_	_	_	_
10	sequence	sequence	NOUN	NN	Number=Sing	_	_	_	_
11	under	under	ADP	IN	_	_	_	_	_
12	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
13	control	control	NOUN	NN	Number=Sing	_	_	_	_
14	of	of	ADP	IN	_	_	_	_	_
15	an	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
16	heterologous	heterologous	ADJ	JJ	Degree=Pos	_	_	_	_
17	promoter	promoter	NOUN	NN	Number=Sing	_	_	_	_
18	restores	restore	NOUN	NNS	Number=Plur	_	_	_	_
19	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
20	of	of	ADP	IN	_	_	_	_	_
21	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
22	MHC	MHC	PROPN	NNP	Number=Sing	_	_	_	_
23	class	class	NOUN	NN	Number=Sing	_	_	_	_
24	II	ii	NUM	CD	NumType=Card	_	_	_	_
25	genes	gene	NOUN	NNS	Number=Plur	_	_	_	_
26	in	in	ADP	IN	_	_	_	_	_
27	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
28	hybrids	hybrid	NOUN	NNS	Number=Plur	_	_	_	_
29	and	and	CCONJ	CC	_	_	_	_	_
30	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
31	responsible	responsible	ADJ	JJ	Degree=Pos	_	_	_	_
32	for	for	ADP	IN	_	_	_	_	_
33	de	de	PROPN	NNP	Number=Sing	_	_	_	_
34	novo	novo	PROPN	NNP	Number=Sing	_	_	_	_
35	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
36	of	of	ADP	IN	_	_	_	_	_
37	mouse	mouse	NOUN	NN	Number=Sing	_	_	_	_
38	MHC	MHC	PROPN	NNP	Number=Sing	_	_	_	_
39	class	class	NOUN	NN	Number=Sing	_	_	_	_
40	II	ii	NUM	CD	NumType=Card	_	_	_	_
41	genes	gene	NOUN	NNS	Number=Plur	_	_	_	_
42	in	in	ADP	IN	_	_	_	_	_
43	both	both	CCONJ	CC	_	_	_	_	_
44	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
45	mouse	mouse	NOUN	NN	Number=Sing	_	_	_	_
46	plasmacytoma	plasmacytoma	NOUN	NN	Number=Sing	_	_	_	_
47	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
48	line	line	NOUN	NN	Number=Sing	_	_	_	_
49	and	and	CCONJ	CC	_	_	_	_	_
50	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
51	hybrids	hybrid	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
52	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 877
# text = These results confirm and extend the notion of the functional conservation of the AIR-1 gene product across species barriers.
1	These	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
2	results	result	NOUN	NNS	Number=Plur	_	_	_	_
3	confirm	confirm	VERB	VB	VerbForm=Inf	_	_	_	_
4	and	and	CCONJ	CC	_	_	_	_	_
5	extend	extend	VERB	VB	VerbForm=Inf	_	_	_	_
6	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
7	notion	notion	NOUN	NN	Number=Sing	_	_	_	_
8	of	of	ADP	IN	_	_	_	_	_
9	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
10	functional	functional	ADJ	JJ	Degree=Pos	_	_	_	_
11	conservation	conservation	NOUN	NN	Number=Sing	_	_	_	_
12	of	of	ADP	IN	_	_	_	_	_
13	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
14	AIR	Air	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
15	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
16	1	1	NUM	CD	NumType=Card	_	_	_	_
17	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
18	product	product	NOUN	NN	Number=Sing	_	_	_	_
19	across	across	ADP	IN	_	_	_	_	_
20	species	species	NOUN	NNS	Number=Plur	_	_	_	_
21	barriers	barrier	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
22	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 878
# text = Interestingly, in CIITA-transfected cell hybrids, cell surface expression of the human HLA-DQ heterodimer was not observed.
1	Interestingly	Interestingly	ADV	RB	_	_	_	_	SpaceAfter=No
2	,	,	PUNCT	,	_	_	_	_	_
3	in	in	ADP	IN	_	_	_	_	_
4	CIITA	CIITA	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
5	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
6	transfected	transfect	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
7	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
8	hybrids	hybrid	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
9	,	,	PUNCT	,	_	_	_	_	_
10	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
11	surface	surface	NOUN	NN	Number=Sing	_	_	_	_
12	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
13	of	of	ADP	IN	_	_	_	_	_
14	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
15	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
16	HLA	HLA	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
17	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
18	DQ	Dq	PROPN	NNP	Number=Sing	_	_	_	_
19	heterodimer	heterodimer	NOUN	NN	Number=Sing	_	_	_	_
20	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
21	not	not	PART	RB	_	_	_	_	_
22	observed	observe	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	SpaceAfter=No
23	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 879
# text = This result was not attributable to lack of HLA-DQ alpha or -DQ beta transcription, because both transcripts were present in the CIITA-transfected hybrids, although at reduced levels.
1	This	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
2	result	result	NOUN	NN	Number=Sing	_	_	_	_
3	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
4	not	not	PART	RB	_	_	_	_	_
5	attributable	attributable	ADJ	JJ	Degree=Pos	_	_	_	_
6	to	to	ADP	IN	_	_	_	_	_
7	lack	lack	NOUN	NN	Number=Sing	_	_	_	_
8	of	of	ADP	IN	_	_	_	_	_
9	HLA	HLA	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
10	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
11	DQ	Dq	PROPN	NNP	Number=Sing	_	_	_	_
12	alpha	alpha	NOUN	NN	Number=Sing	_	_	_	_
13	or	or	CCONJ	CC	_	_	_	_	_
14	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
15	DQ	Dq	ADJ	JJ	Degree=Pos	_	_	_	_
16	beta	beta	NOUN	NN	Number=Sing	_	_	_	_
17	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
18	,	,	PUNCT	,	_	_	_	_	_
19	because	because	SCONJ	IN	_	_	_	_	_
20	both	both	DET	DT	_	_	_	_	_
21	transcripts	transcript	NOUN	NNS	Number=Plur	_	_	_	_
22	were	be	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
23	present	present	ADJ	JJ	Degree=Pos	_	_	_	_
24	in	in	ADP	IN	_	_	_	_	_
25	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
26	CIITA	CIITA	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
27	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
28	transfected	transfect	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
29	hybrids	hybrid	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
30	,	,	PUNCT	,	_	_	_	_	_
31	although	although	SCONJ	IN	_	_	_	_	_
32	at	at	ADP	IN	_	_	_	_	_
33	reduced	reduce	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
34	levels	level	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
35	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 880
# text = These findings further support our previous observations on the distinct regulation of expression of the human HLA-DQ class II subset, which may be thus controlled at the posttranscriptional level by a CIITA-independent mechanism.
1	These	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
2	findings	finding	NOUN	NNS	Number=Plur	_	_	_	_
3	further	further	ADV	RB	_	_	_	_	_
4	support	support	VERB	VB	Mood=Imp|VerbForm=Fin	_	_	_	_
5	our	we	PRON	PRP$	Number=Plur|Person=1|Poss=Yes|PronType=Prs	_	_	_	_
6	previous	previous	ADJ	JJ	Degree=Pos	_	_	_	_
7	observations	observation	NOUN	NNS	Number=Plur	_	_	_	_
8	on	on	ADP	IN	_	_	_	_	_
9	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
10	distinct	distinct	ADJ	JJ	Degree=Pos	_	_	_	_
11	regulation	regulation	NOUN	NN	Number=Sing	_	_	_	_
12	of	of	ADP	IN	_	_	_	_	_
13	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
14	of	of	ADP	IN	_	_	_	_	_
15	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
16	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
17	HLA	HLa	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
18	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
19	DQ	Dq	NOUN	NN	Number=Sing	_	_	_	_
20	class	class	NOUN	NN	Number=Sing	_	_	_	_
21	II	ii	NUM	CD	NumType=Card	_	_	_	_
22	subset	subset	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
23	,	,	PUNCT	,	_	_	_	_	_
24	which	which	PRON	WDT	PronType=Rel	_	_	_	_
25	may	may	AUX	MD	VerbForm=Fin	_	_	_	_
26	be	be	AUX	VB	VerbForm=Inf	_	_	_	_
27	thus	thus	ADV	RB	_	_	_	_	_
28	controlled	control	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
29	at	at	ADP	IN	_	_	_	_	_
30	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
31	posttranscriptional	posttranscriptional	ADJ	JJ	Degree=Pos	_	_	_	_
32	level	level	NOUN	NN	Number=Sing	_	_	_	_
33	by	by	ADP	IN	_	_	_	_	_
34	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
35	CIITA	CIITA	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
36	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
37	independent	independent	ADJ	JJ	Degree=Pos	_	_	_	_
38	mechanism	mechanism	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
39	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 881
# text = Document 003002324 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	003002324	003002324	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 882
# text = Suppression of NF-kappaB activation in normal T cells by supernatant fluid from human renal cell carcinomas.
1	Suppression	Suppression	NOUN	NN	Number=Sing	_	_	_	_
2	of	of	ADP	IN	_	_	_	_	_
3	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
4	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
5	kappaB	kappaB	PROPN	NNP	Number=Sing	_	_	_	_
6	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
7	in	in	ADP	IN	_	_	_	_	_
8	normal	normal	ADJ	JJ	Degree=Pos	_	_	_	_
9	T	t	PROPN	NNP	Number=Sing	_	_	_	_
10	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
11	by	by	ADP	IN	_	_	_	_	_
12	supernatant	supernatant	ADJ	JJ	Degree=Pos	_	_	_	_
13	fluid	fluid	NOUN	NN	Number=Sing	_	_	_	_
14	from	from	ADP	IN	_	_	_	_	_
15	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
16	renal	renal	ADJ	JJ	Degree=Pos	_	_	_	_
17	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
18	carcinomas	carcinoma	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
19	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 883
# text = T lymphocytes from patients with renal cell carcinoma (RCC) show reduced immune function and impaired activation of the transcription factor, NF-kappaB.
1	T	t	PROPN	NNP	Number=Sing	_	_	_	_
2	lymphocytes	lymphocyte	NOUN	NNS	Number=Plur	_	_	_	_
3	from	from	ADP	IN	_	_	_	_	_
4	patients	patient	NOUN	NNS	Number=Plur	_	_	_	_
5	with	with	ADP	IN	_	_	_	_	_
6	renal	renal	ADJ	JJ	Degree=Pos	_	_	_	_
7	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
8	carcinoma	carcinoma	NOUN	NN	Number=Sing	_	_	_	_
9	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
10	RCC	RCC	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
11	)	)	PUNCT	-RRB-	_	_	_	_	_
12	show	show	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
13	reduced	reduce	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
14	immune	immune	ADJ	JJ	Degree=Pos	_	_	_	_
15	function	function	NOUN	NN	Number=Sing	_	_	_	_
16	and	and	CCONJ	CC	_	_	_	_	_
17	impaired	impaire	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
18	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
19	of	of	ADP	IN	_	_	_	_	_
20	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
21	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
22	factor	factor	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
23	,	,	PUNCT	,	_	_	_	_	_
24	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
25	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
26	kappaB	kappaB	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
27	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 884
# text = We determined the mechanism of NF-kappaB suppression in T cells of RCC patient and determined whether supernatant fluid from RCC explants (RCC-S) induced the same phenotype of NF-kappaB suppression in normal T cells that is observed in patient T cells.
1	We	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
2	determined	determine	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
3	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
4	mechanism	mechanism	NOUN	NN	Number=Sing	_	_	_	_
5	of	of	ADP	IN	_	_	_	_	_
6	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
7	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
8	kappaB	kappaB	PROPN	NNP	Number=Sing	_	_	_	_
9	suppression	suppression	NOUN	NN	Number=Sing	_	_	_	_
10	in	in	ADP	IN	_	_	_	_	_
11	T	t	PROPN	NNP	Number=Sing	_	_	_	_
12	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
13	of	of	ADP	IN	_	_	_	_	_
14	RCC	Rcc	NOUN	NN	Number=Sing	_	_	_	_
15	patient	patient	NOUN	NN	Number=Sing	_	_	_	_
16	and	and	CCONJ	CC	_	_	_	_	_
17	determined	determine	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
18	whether	whether	SCONJ	IN	_	_	_	_	_
19	supernatant	supernatant	ADJ	JJ	Degree=Pos	_	_	_	_
20	fluid	fluid	NOUN	NN	Number=Sing	_	_	_	_
21	from	from	ADP	IN	_	_	_	_	_
22	RCC	RCC	PROPN	NNP	Number=Sing	_	_	_	_
23	explants	explant	NOUN	NNS	Number=Plur	_	_	_	_
24	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
25	RCC	RCC	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
26	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
27	S	s	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
28	)	)	PUNCT	-RRB-	_	_	_	_	_
29	induced	induce	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
30	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
31	same	same	ADJ	JJ	Degree=Pos	_	_	_	_
32	phenotype	phenotype	NOUN	NN	Number=Sing	_	_	_	_
33	of	of	ADP	IN	_	_	_	_	_
34	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
35	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
36	kappaB	kappaB	PROPN	NNP	Number=Sing	_	_	_	_
37	suppression	suppression	NOUN	NN	Number=Sing	_	_	_	_
38	in	in	ADP	IN	_	_	_	_	_
39	normal	normal	ADJ	JJ	Degree=Pos	_	_	_	_
40	T	t	PROPN	NNP	Number=Sing	_	_	_	_
41	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
42	that	that	PRON	WDT	PronType=Rel	_	_	_	_
43	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
44	observed	observe	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
45	in	in	ADP	IN	_	_	_	_	_
46	patient	patient	ADJ	JJ	Degree=Pos	_	_	_	_
47	T	t	PROPN	NNP	Number=Sing	_	_	_	_
48	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
49	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 885
# text = The pattern of kappaB-binding activity in T cells of RCC patient was altered as compared to that seen in T cells obtained from normal volunteers.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	pattern	pattern	NOUN	NN	Number=Sing	_	_	_	_
3	of	of	ADP	IN	_	_	_	_	_
4	kappaB	kappaB	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
5	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
6	binding	bind	VERB	VBG	VerbForm=Ger	_	_	_	_
7	activity	activity	NOUN	NN	Number=Sing	_	_	_	_
8	in	in	ADP	IN	_	_	_	_	_
9	T	t	PROPN	NNP	Number=Sing	_	_	_	_
10	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
11	of	of	ADP	IN	_	_	_	_	_
12	RCC	RCC	PROPN	NNP	Number=Sing	_	_	_	_
13	patient	patient	NOUN	NN	Number=Sing	_	_	_	_
14	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
15	altered	alter	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
16	as	as	ADP	IN	_	_	_	_	_
17	compared	compare	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
18	to	to	ADP	IN	_	_	_	_	_
19	that	that	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
20	seen	see	NOUN	NN	Number=Sing	_	_	_	_
21	in	in	ADP	IN	_	_	_	_	_
22	T	t	PROPN	NNP	Number=Sing	_	_	_	_
23	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
24	obtained	obtaine	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
25	from	from	ADP	IN	_	_	_	_	_
26	normal	normal	ADJ	JJ	Degree=Pos	_	_	_	_
27	volunteers	volunteer	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
28	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 886
# text = In some patients, no activation of RelA/NFkappaB1-binding activity was detectable, while in others kappaB-binding activity was modestly induced but the duration was reduced.
1	In	in	ADP	IN	_	_	_	_	_
2	some	some	DET	DT	_	_	_	_	_
3	patients	patient	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	,	,	PUNCT	,	_	_	_	_	_
5	no	no	DET	DT	_	_	_	_	_
6	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
7	of	of	ADP	IN	_	_	_	_	_
8	RelA/NFkappaB1	RelA/NFkappaB1	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
9	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
10	binding	binding	VERB	VBG	VerbForm=Ger	_	_	_	_
11	activity	activity	NOUN	NN	Number=Sing	_	_	_	_
12	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
13	detectable	detectable	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
14	,	,	PUNCT	,	_	_	_	_	_
15	while	while	SCONJ	IN	_	_	_	_	_
16	in	in	ADP	IN	_	_	_	_	_
17	others	other	NOUN	NNS	Number=Plur	_	_	_	_
18	kappaB	kappaB	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
19	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
20	binding	binding	VERB	VBG	VerbForm=Ger	_	_	_	_
21	activity	activity	NOUN	NN	Number=Sing	_	_	_	_
22	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
23	modestly	modestly	ADV	RB	_	_	_	_	_
24	induced	induce	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
25	but	but	CCONJ	CC	_	_	_	_	_
26	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
27	duration	duration	NOUN	NN	Number=Sing	_	_	_	_
28	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
29	reduced	reduce	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	SpaceAfter=No
30	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 887
# text = IkappaBalpha was degraded normally following stimulation in both normal controls and T cells from RCC patients.
1	IkappaBalpha	IkappaBalpha	PROPN	NNP	Number=Sing	_	_	_	_
2	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
3	degraded	degrad	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
4	normally	normally	ADV	RB	_	_	_	_	_
5	following	follow	VERB	VBG	VerbForm=Ger	_	_	_	_
6	stimulation	stimulation	NOUN	NN	Number=Sing	_	_	_	_
7	in	in	ADP	IN	_	_	_	_	_
8	both	both	DET	DT	_	_	_	_	_
9	normal	normal	ADJ	JJ	Degree=Pos	_	_	_	_
10	controls	control	NOUN	NNS	Number=Plur	_	_	_	_
11	and	and	CCONJ	CC	_	_	_	_	_
12	T	t	PROPN	NNP	Number=Sing	_	_	_	_
13	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
14	from	from	ADP	IN	_	_	_	_	_
15	RCC	RCC	PROPN	NNP	Number=Sing	_	_	_	_
16	patients	patient	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
17	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 888
# text = RCC-S did not alter the cytoplasmic levels of RelA and NF-kappaB1 but did suppress their nuclear localization and inhibited the activation of RelA/NF-kappaB1 binding complexes.
1	RCC	RCC	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
2	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
3	S	S	PROPN	NNP	Number=Sing	_	_	_	_
4	did	do	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
5	not	not	PART	RB	_	_	_	_	_
6	alter	alter	VERB	VB	VerbForm=Inf	_	_	_	_
7	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
8	cytoplasmic	cytoplasmic	ADJ	JJ	Degree=Pos	_	_	_	_
9	levels	level	NOUN	NNS	Number=Plur	_	_	_	_
10	of	of	ADP	IN	_	_	_	_	_
11	RelA	RelA	PROPN	NNP	Number=Sing	_	_	_	_
12	and	and	CCONJ	CC	_	_	_	_	_
13	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
14	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
15	kappaB1	kappaB1	PROPN	NNP	Number=Sing	_	_	_	_
16	but	but	CCONJ	CC	_	_	_	_	_
17	did	do	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
18	suppress	suppress	VERB	VB	VerbForm=Inf	_	_	_	_
19	their	they	PRON	PRP$	Number=Plur|Person=3|Poss=Yes|PronType=Prs	_	_	_	_
20	nuclear	nuclear	ADJ	JJ	Degree=Pos	_	_	_	_
21	localization	localization	NOUN	NN	Number=Sing	_	_	_	_
22	and	and	CCONJ	CC	_	_	_	_	_
23	inhibited	inhibit	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
24	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
25	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
26	of	of	ADP	IN	_	_	_	_	_
27	RelA	RelA	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
28	/	/	PUNCT	,	_	_	_	_	SpaceAfter=No
29	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
30	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
31	kappaB1	kappaB1	PROPN	NNP	Number=Sing	_	_	_	_
32	binding	binding	VERB	VBG	VerbForm=Ger	_	_	_	_
33	complexes	complex	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
34	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 889
# text = These results show that RCC-S can induce in normal T cells the same phenotype of impaired NF-kappaB activation that is detected in T cells of RCC patient.
1	These	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
2	results	result	NOUN	NNS	Number=Plur	_	_	_	_
3	show	show	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
4	that	that	SCONJ	IN	_	_	_	_	_
5	RCC	RCC	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
6	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
7	S	s	PROPN	NNP	Number=Sing	_	_	_	_
8	can	can	AUX	MD	VerbForm=Fin	_	_	_	_
9	induce	induce	VERB	VB	VerbForm=Inf	_	_	_	_
10	in	in	ADP	IN	_	_	_	_	_
11	normal	normal	ADJ	JJ	Degree=Pos	_	_	_	_
12	T	t	PROPN	NNP	Number=Sing	_	_	_	_
13	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
14	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
15	same	same	ADJ	JJ	Degree=Pos	_	_	_	_
16	phenotype	phenotype	NOUN	NN	Number=Sing	_	_	_	_
17	of	of	ADP	IN	_	_	_	_	_
18	impaired	impaire	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
19	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
20	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
21	kappaB	kappaB	PROPN	NNP	Number=Sing	_	_	_	_
22	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
23	that	that	PRON	WDT	PronType=Rel	_	_	_	_
24	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
25	detected	detect	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
26	in	in	ADP	IN	_	_	_	_	_
27	T	t	PROPN	NNP	Number=Sing	_	_	_	_
28	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
29	of	of	ADP	IN	_	_	_	_	_
30	RCC	RCC	NOUN	NN	Number=Sing	_	_	_	_
31	patient	patient	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
32	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 890
# text = It also appears that NF-kappaB suppression by RCC-S may contribute to the immunosuppression of host immunity.
1	It	it	PRON	PRP	Case=Nom|Gender=Neut|Number=Sing|Person=3|PronType=Prs	_	_	_	_
2	also	also	ADV	RB	_	_	_	_	_
3	appears	appear	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
4	that	that	SCONJ	IN	_	_	_	_	_
5	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
6	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
7	kappaB	kappaB	PROPN	NNP	Number=Sing	_	_	_	_
8	suppression	suppression	NOUN	NN	Number=Sing	_	_	_	_
9	by	by	ADP	IN	_	_	_	_	_
10	RCC	RCC	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
11	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
12	S	s	PROPN	NNP	Number=Sing	_	_	_	_
13	may	may	AUX	MD	VerbForm=Fin	_	_	_	_
14	contribute	contribute	VERB	VB	VerbForm=Inf	_	_	_	_
15	to	to	ADP	IN	_	_	_	_	_
16	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
17	immunosuppression	immunosuppression	NOUN	NN	Number=Sing	_	_	_	_
18	of	of	ADP	IN	_	_	_	_	_
19	host	host	NOUN	NN	Number=Sing	_	_	_	_
20	immunity	immunity	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
21	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 891
# text = Document 003002325 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	003002325	003002325	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 892
# text = An isotype-specific activator of major histocompatibility complex (MHC) class II genes that is independent of class II transactivator.
1	An	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
2	isotype-specific	isotype-specific	ADJ	JJ	Degree=Pos	_	_	_	_
3	activator	activator	NOUN	NN	Number=Sing	_	_	_	_
4	of	of	ADP	IN	_	_	_	_	_
5	major	major	ADJ	JJ	Degree=Pos	_	_	_	_
6	histocompatibility	histocompatibility	NOUN	NN	Number=Sing	_	_	_	_
7	complex	complex	NOUN	NN	Number=Sing	_	_	_	_
8	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
9	MHC	MHC	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
10	)	)	PUNCT	-RRB-	_	_	_	_	_
11	class	class	NOUN	NN	Number=Sing	_	_	_	_
12	II	ii	NUM	CD	NumType=Card	_	_	_	_
13	genes	gene	NOUN	NNS	Number=Plur	_	_	_	_
14	that	that	PRON	WDT	PronType=Rel	_	_	_	_
15	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
16	independent	independent	ADJ	JJ	Degree=Pos	_	_	_	_
17	of	of	ADP	IN	_	_	_	_	_
18	class	class	NOUN	NN	Number=Sing	_	_	_	_
19	II	ii	NUM	CD	NumType=Card	_	_	_	_
20	transactivator	transactivator	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
21	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 893
# text = Patients with one type of major histocompatibility complex class II combined immunodeficiency have mutations in a gene termed class II transactivator (CIITA), which coordinately controls the transcription of the three major human class II genes, HLA-DR, -DQ, and -DP.
1	Patients	patient	NOUN	NNS	Number=Plur	_	_	_	_
2	with	with	ADP	IN	_	_	_	_	_
3	one	one	NUM	CD	NumType=Card	_	_	_	_
4	type	type	NOUN	NN	Number=Sing	_	_	_	_
5	of	of	ADP	IN	_	_	_	_	_
6	major	major	ADJ	JJ	Degree=Pos	_	_	_	_
7	histocompatibility	histocompatibility	NOUN	NN	Number=Sing	_	_	_	_
8	complex	complex	NOUN	NN	Number=Sing	_	_	_	_
9	class	class	NOUN	NN	Number=Sing	_	_	_	_
10	II	ii	NUM	CD	NumType=Card	_	_	_	_
11	combined	combine	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
12	immunodeficiency	immunodeficiency	NOUN	NN	Number=Sing	_	_	_	_
13	have	have	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
14	mutations	mutation	NOUN	NNS	Number=Plur	_	_	_	_
15	in	in	ADP	IN	_	_	_	_	_
16	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
17	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
18	termed	term	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
19	class	class	NOUN	NN	Number=Sing	_	_	_	_
20	II	ii	NUM	CD	NumType=Card	_	_	_	_
21	transactivator	transactivator	NOUN	NN	Number=Sing	_	_	_	_
22	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
23	CIITA	CIITA	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
24	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
25	,	,	PUNCT	,	_	_	_	_	_
26	which	which	PRON	WDT	PronType=Rel	_	_	_	_
27	coordinately	coordinately	ADV	RB	_	_	_	_	_
28	controls	control	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
29	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
30	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
31	of	of	ADP	IN	_	_	_	_	_
32	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
33	three	three	NUM	CD	NumType=Card	_	_	_	_
34	major	major	ADJ	JJ	Degree=Pos	_	_	_	_
35	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
36	class	class	NOUN	NN	Number=Sing	_	_	_	_
37	II	ii	NUM	CD	NumType=Card	_	_	_	_
38	genes	gene	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
39	,	,	PUNCT	,	_	_	_	_	_
40	HLA	HLA	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
41	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
42	DR	dr	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
43	,	,	PUNCT	,	_	_	_	_	_
44	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
45	DQ	Dq	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
46	,	,	PUNCT	,	_	_	_	_	_
47	and	and	CCONJ	CC	_	_	_	_	_
48	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
49	DP	DP	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
50	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 894
# text = However, the experimentally derived B-lymphoblastoid cell line, clone 13, expresses high levels of HLADQ in the absence of HLA-DR and HLA-DP, despite its mapping by complementation analysis to this group.
1	However	however	ADV	RB	_	_	_	_	SpaceAfter=No
2	,	,	PUNCT	,	_	_	_	_	_
3	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
4	experimentally	experimentally	ADV	RB	_	_	_	_	_
5	derived	derive	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
6	B	b	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
7	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
8	lymphoblastoid	lymphoblastoid	NOUN	NN	Number=Sing	_	_	_	_
9	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
10	line	line	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
11	,	,	PUNCT	,	_	_	_	_	_
12	clone	clone	NOUN	NN	Number=Sing	_	_	_	_
13	13	13	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
14	,	,	PUNCT	,	_	_	_	_	_
15	expresses	expresse	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
16	high	high	ADJ	JJ	Degree=Pos	_	_	_	_
17	levels	level	NOUN	NNS	Number=Plur	_	_	_	_
18	of	of	ADP	IN	_	_	_	_	_
19	HLADQ	HLADq	NOUN	NN	Number=Sing	_	_	_	_
20	in	in	ADP	IN	_	_	_	_	_
21	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
22	absence	absence	NOUN	NN	Number=Sing	_	_	_	_
23	of	of	ADP	IN	_	_	_	_	_
24	HLA	HLA	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
25	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
26	DR	dr	PROPN	NNP	Number=Sing	_	_	_	_
27	and	and	CCONJ	CC	_	_	_	_	_
28	HLA	HLA	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
29	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
30	DP	DP	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
31	,	,	PUNCT	,	_	_	_	_	_
32	despite	despite	ADP	IN	_	_	_	_	_
33	its	its	PRON	PRP$	Gender=Neut|Number=Sing|Person=3|Poss=Yes|PronType=Prs	_	_	_	_
34	mapping	mapping	NOUN	NN	Number=Sing	_	_	_	_
35	by	by	ADP	IN	_	_	_	_	_
36	complementation	complementation	NOUN	NN	Number=Sing	_	_	_	_
37	analysis	analysis	NOUN	NN	Number=Sing	_	_	_	_
38	to	to	ADP	IN	_	_	_	_	_
39	this	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
40	group	group	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
41	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 895
# text = It was possible that one of the clone 13 CIITA alleles bore a mutation that allowed HLA-DQ, but not HLA-DR or -DP transcription.
1	It	it	PRON	PRP	Case=Nom|Gender=Neut|Number=Sing|Person=3|PronType=Prs	_	_	_	_
2	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
3	possible	possible	ADJ	JJ	Degree=Pos	_	_	_	_
4	that	that	SCONJ	IN	_	_	_	_	_
5	one	one	NUM	CD	NumType=Card	_	_	_	_
6	of	of	ADP	IN	_	_	_	_	_
7	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
8	clone	clone	NOUN	NN	Number=Sing	_	_	_	_
9	13	13	NUM	CD	NumType=Card	_	_	_	_
10	CIITA	CIITA	PROPN	NNP	Number=Sing	_	_	_	_
11	alleles	allele	NOUN	NNS	Number=Plur	_	_	_	_
12	bore	bear	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
13	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
14	mutation	mutation	NOUN	NN	Number=Sing	_	_	_	_
15	that	that	PRON	WDT	PronType=Rel	_	_	_	_
16	allowed	allow	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
17	HLA	HLA	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
18	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
19	DQ	Dq	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
20	,	,	PUNCT	,	_	_	_	_	_
21	but	but	CCONJ	CC	_	_	_	_	_
22	not	not	ADV	RB	_	_	_	_	_
23	HLA	HLA	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
24	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
25	DR	dr	PROPN	NNP	Number=Sing	_	_	_	_
26	or	or	CCONJ	CC	_	_	_	_	_
27	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
28	DP	Dp	ADJ	JJ	Degree=Pos	_	_	_	_
29	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
30	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 896
# text = Alternatively, another factor, distinct from CIITA, might control HLA-DQ expression.
1	Alternatively	Alternatively	ADV	RB	_	_	_	_	SpaceAfter=No
2	,	,	PUNCT	,	_	_	_	_	_
3	another	another	DET	DT	_	_	_	_	_
4	factor	factor	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
5	,	,	PUNCT	,	_	_	_	_	_
6	distinct	distinct	ADJ	JJ	Degree=Pos	_	_	_	_
7	from	from	ADP	IN	_	_	_	_	_
8	CIITA	CIITA	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
9	,	,	PUNCT	,	_	_	_	_	_
10	might	might	AUX	MD	VerbForm=Fin	_	_	_	_
11	control	control	VERB	VB	VerbForm=Inf	_	_	_	_
12	HLA	HLA	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
13	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
14	DQ	Dq	PROPN	NNP	Number=Sing	_	_	_	_
15	expression	expression	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
16	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 897
# text = We report here that ectopic expression of CIITA cDNAs derived by reverse transcriptase polymerase chain reaction from clone 13 do not restore expression of HLA-DQ in another CIITA-deficient cell line, RJ2.2.5.
1	We	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
2	report	report	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
3	here	here	ADV	RB	PronType=Dem	_	_	_	_
4	that	that	SCONJ	IN	_	_	_	_	_
5	ectopic	ectopic	ADJ	JJ	Degree=Pos	_	_	_	_
6	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
7	of	of	ADP	IN	_	_	_	_	_
8	CIITA	CIITA	PROPN	NNP	Number=Sing	_	_	_	_
9	cDNAs	cDNAs	NOUN	NNS	Number=Plur	_	_	_	_
10	derived	derive	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
11	by	by	ADP	IN	_	_	_	_	_
12	reverse	reverse	NOUN	NN	Number=Sing	_	_	_	_
13	transcriptase	transcriptase	NOUN	NN	Number=Sing	_	_	_	_
14	polymerase	polymerase	NOUN	NN	Number=Sing	_	_	_	_
15	chain	chain	NOUN	NN	Number=Sing	_	_	_	_
16	reaction	reaction	NOUN	NN	Number=Sing	_	_	_	_
17	from	from	ADP	IN	_	_	_	_	_
18	clone	clone	NOUN	NN	Number=Sing	_	_	_	_
19	13	13	NUM	CD	NumType=Card	_	_	_	_
20	do	do	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
21	not	not	PART	RB	_	_	_	_	_
22	restore	restore	VERB	VB	VerbForm=Inf	_	_	_	_
23	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
24	of	of	ADP	IN	_	_	_	_	_
25	HLA	HLA	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
26	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
27	DQ	Dq	PROPN	NNP	Number=Sing	_	_	_	_
28	in	in	ADP	IN	_	_	_	_	_
29	another	another	DET	DT	_	_	_	_	_
30	CIITA	CIITa	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
31	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
32	deficient	deficient	ADJ	JJ	Degree=Pos	_	_	_	_
33	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
34	line	line	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
35	,	,	PUNCT	,	_	_	_	_	_
36	RJ	RJ	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
37	2.2.5	2.2.5	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
38	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 898
# text = In addition, no CIITA protein is detectable in clone 13 nuclear extracts.
1	In	in	ADP	IN	_	_	_	_	_
2	addition	addition	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
3	,	,	PUNCT	,	_	_	_	_	_
4	no	no	DET	DT	_	_	_	_	_
5	CIITA	CIITa	NOUN	NN	Number=Sing	_	_	_	_
6	protein	protein	NOUN	NN	Number=Sing	_	_	_	_
7	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
8	detectable	detectable	ADJ	JJ	Degree=Pos	_	_	_	_
9	in	in	ADP	IN	_	_	_	_	_
10	clone	clone	NOUN	NN	Number=Sing	_	_	_	_
11	13	13	NUM	CD	NumType=Card	_	_	_	_
12	nuclear	nuclear	ADJ	JJ	Degree=Pos	_	_	_	_
13	extracts	extract	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
14	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 899
# text = In contrast, somatic cell fusion between clone 13 and RJ2.2.5 restored expression of the HLA-DQ haplotype encoded by the RJ2.2.5 DQB gene.
1	In	in	ADP	IN	_	_	_	_	_
2	contrast	contrast	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
3	,	,	PUNCT	,	_	_	_	_	_
4	somatic	somatic	ADJ	JJ	Degree=Pos	_	_	_	_
5	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
6	fusion	fusion	NOUN	NN	Number=Sing	_	_	_	_
7	between	between	ADP	IN	_	_	_	_	_
8	clone	clone	NOUN	NN	Number=Sing	_	_	_	_
9	13	13	NUM	CD	NumType=Card	_	_	_	_
10	and	and	CCONJ	CC	_	_	_	_	_
11	RJ2.2.5	RJ2.2.5	NUM	CD	NumType=Card	_	_	_	_
12	restored	restore	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
13	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
14	of	of	ADP	IN	_	_	_	_	_
15	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
16	HLA	HLA	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
17	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
18	DQ	Dq	PROPN	NNP	Number=Sing	_	_	_	_
19	haplotype	haplotype	NOUN	NN	Number=Sing	_	_	_	_
20	encoded	encod	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
21	by	by	ADP	IN	_	_	_	_	_
22	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
23	RJ2.2.5	RJ2.2.5	PROPN	NNP	Number=Sing	_	_	_	_
24	DQB	DQB	PROPN	NNP	Number=Sing	_	_	_	_
25	gene	gene	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
26	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 900
# text = Taken together, these data demonstrate the existence of an HLA-DQ isotype-specific trans-acting factor, which functions independently of CIITA.
1	Taken	take	PROPN	NNP	Number=Sing	_	_	_	_
2	together	together	ADV	RB	_	_	_	_	SpaceAfter=No
3	,	,	PUNCT	,	_	_	_	_	_
4	these	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
5	data	data	NOUN	NN	Number=Sing	_	_	_	_
6	demonstrate	demonstrate	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
7	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
8	existence	existence	NOUN	NN	Number=Sing	_	_	_	_
9	of	of	ADP	IN	_	_	_	_	_
10	an	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
11	HLA	HLa	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
12	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
13	DQ	Dq	NOUN	NN	Number=Sing	_	_	_	_
14	isotype-specific	isotype-specific	ADJ	JJ	Degree=Pos	_	_	_	_
15	trans	tran	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
16	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
17	acting	act	VERB	VBG	VerbForm=Ger	_	_	_	_
18	factor	factor	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
19	,	,	PUNCT	,	_	_	_	_	_
20	which	which	PRON	WDT	PronType=Rel	_	_	_	_
21	functions	function	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
22	independently	independently	ADV	RB	_	_	_	_	_
23	of	of	ADP	IN	_	_	_	_	_
24	CIITA	CIITA	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
25	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 901
# text = Document 003002328 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	003002328	003002328	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 902
# text = CIITA activates the expression of MHC class II genes in mouse T cells.
1	CIITA	CIITA	PROPN	NNP	Number=Sing	_	_	_	_
2	activates	activate	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
3	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
4	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
5	of	of	ADP	IN	_	_	_	_	_
6	MHC	MHC	PROPN	NNP	Number=Sing	_	_	_	_
7	class	class	NOUN	NN	Number=Sing	_	_	_	_
8	II	ii	NUM	CD	NumType=Card	_	_	_	_
9	genes	gene	NOUN	NNS	Number=Plur	_	_	_	_
10	in	in	ADP	IN	_	_	_	_	_
11	mouse	mouse	NOUN	NN	Number=Sing	_	_	_	_
12	T	t	PROPN	NNP	Number=Sing	_	_	_	_
13	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
14	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 903
# text = It has long been a puzzle that MHC class II molecules are expressed in human T cells after activation but not in mouse T cells; this expression is believed to play a role in the cell mediated immune response.
1	It	it	PRON	PRP	Case=Nom|Gender=Neut|Number=Sing|Person=3|PronType=Prs	_	_	_	_
2	has	have	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
3	long	long	ADV	RB	Degree=Pos	_	_	_	_
4	been	be	AUX	VBN	Tense=Past|VerbForm=Part	_	_	_	_
5	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
6	puzzle	puzzle	NOUN	NN	Number=Sing	_	_	_	_
7	that	that	PRON	WDT	PronType=Rel	_	_	_	_
8	MHC	MHC	PROPN	NNP	Number=Sing	_	_	_	_
9	class	class	NOUN	NN	Number=Sing	_	_	_	_
10	II	ii	NUM	CD	NumType=Card	_	_	_	_
11	molecules	molecule	NOUN	NNS	Number=Plur	_	_	_	_
12	are	be	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
13	expressed	express	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
14	in	in	ADP	IN	_	_	_	_	_
15	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
16	T	t	PROPN	NNP	Number=Sing	_	_	_	_
17	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
18	after	after	ADP	IN	_	_	_	_	_
19	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
20	but	but	CCONJ	CC	_	_	_	_	_
21	not	not	PART	RB	_	_	_	_	_
22	in	in	ADP	IN	_	_	_	_	_
23	mouse	mouse	NOUN	NN	Number=Sing	_	_	_	_
24	T	t	PROPN	NNP	Number=Sing	_	_	_	_
25	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
26	;	;	PUNCT	,	_	_	_	_	_
27	this	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
28	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
29	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
30	believed	believe	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
31	to	to	PART	TO	_	_	_	_	_
32	play	play	VERB	VB	VerbForm=Inf	_	_	_	_
33	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
34	role	role	NOUN	NN	Number=Sing	_	_	_	_
35	in	in	ADP	IN	_	_	_	_	_
36	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
37	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
38	mediated	mediate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
39	immune	immune	ADJ	JJ	Degree=Pos	_	_	_	_
40	response	response	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
41	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 904
# text = Recently the MHC class II transactivator (CIITA) has been reported to be a major regulatory factor for both the constitutive and IFN inducible expression of MHC class II genes.
1	Recently	recently	ADV	RB	_	_	_	_	_
2	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
3	MHC	MHC	PROPN	NNP	Number=Sing	_	_	_	_
4	class	class	NOUN	NN	Number=Sing	_	_	_	_
5	II	ii	NUM	CD	NumType=Card	_	_	_	_
6	transactivator	transactivator	NOUN	NN	Number=Sing	_	_	_	_
7	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
8	CIITA	CIITA	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
9	)	)	PUNCT	-RRB-	_	_	_	_	_
10	has	have	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
11	been	be	AUX	VBN	Tense=Past|VerbForm=Part	_	_	_	_
12	reported	report	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
13	to	to	PART	TO	_	_	_	_	_
14	be	be	AUX	VB	VerbForm=Inf	_	_	_	_
15	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
16	major	major	ADJ	JJ	Degree=Pos	_	_	_	_
17	regulatory	regulatory	ADJ	JJ	Degree=Pos	_	_	_	_
18	factor	factor	NOUN	NN	Number=Sing	_	_	_	_
19	for	for	ADP	IN	_	_	_	_	_
20	both	both	CCONJ	CC	_	_	_	_	_
21	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
22	constitutive	constitutive	ADJ	JJ	Degree=Pos	_	_	_	_
23	and	and	CCONJ	CC	_	_	_	_	_
24	IFN	Ifn	ADJ	JJ	Degree=Pos	_	_	_	_
25	inducible	inducible	ADJ	JJ	Degree=Pos	_	_	_	_
26	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
27	of	of	ADP	IN	_	_	_	_	_
28	MHC	MHC	PROPN	NNP	Number=Sing	_	_	_	_
29	class	class	NOUN	NN	Number=Sing	_	_	_	_
30	II	ii	NUM	CD	NumType=Card	_	_	_	_
31	genes	gene	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
32	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 905
# text = Here we show that human T cells expressing MHC class II have CIITA transcripts while MHC class II-negative human T cells and mouse T cells do not.
1	Here	here	ADV	RB	PronType=Dem	_	_	_	_
2	we	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
3	show	show	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
4	that	that	SCONJ	IN	_	_	_	_	_
5	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
6	T	t	PROPN	NNP	Number=Sing	_	_	_	_
7	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
8	expressing	expresse	VERB	VBG	VerbForm=Ger	_	_	_	_
9	MHC	MHC	PROPN	NNP	Number=Sing	_	_	_	_
10	class	class	NOUN	NN	Number=Sing	_	_	_	_
11	II	II	PRON	PRP	Case=Nom|Number=Sing|Person=1|PronType=Prs	_	_	_	_
12	have	have	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
13	CIITA	CIITa	NOUN	NN	Number=Sing	_	_	_	_
14	transcripts	transcript	NOUN	NNS	Number=Plur	_	_	_	_
15	while	while	SCONJ	IN	_	_	_	_	_
16	MHC	MHC	PROPN	NNP	Number=Sing	_	_	_	_
17	class	class	NOUN	NN	Number=Sing	_	_	_	_
18	II	ii	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
19	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
20	negative	negative	ADJ	JJ	Degree=Pos	_	_	_	_
21	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
22	T	t	PROPN	NNP	Number=Sing	_	_	_	_
23	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
24	and	and	CCONJ	CC	_	_	_	_	_
25	mouse	mouse	NOUN	NN	Number=Sing	_	_	_	_
26	T	t	PROPN	NNP	Number=Sing	_	_	_	_
27	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
28	do	do	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
29	not	not	PART	RB	_	_	_	_	SpaceAfter=No
30	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 906
# text = The expression of MHC class II genes in mouse T cells can be reconstituted upon transfection with the human CIITA cDNA.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
3	of	of	ADP	IN	_	_	_	_	_
4	MHC	MHC	PROPN	NNP	Number=Sing	_	_	_	_
5	class	class	NOUN	NN	Number=Sing	_	_	_	_
6	II	ii	NUM	CD	NumType=Card	_	_	_	_
7	genes	gene	NOUN	NNS	Number=Plur	_	_	_	_
8	in	in	ADP	IN	_	_	_	_	_
9	mouse	mouse	NOUN	NN	Number=Sing	_	_	_	_
10	T	t	PROPN	NNP	Number=Sing	_	_	_	_
11	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
12	can	can	AUX	MD	VerbForm=Fin	_	_	_	_
13	be	be	AUX	VB	VerbForm=Inf	_	_	_	_
14	reconstituted	reconstitute	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
15	upon	upon	ADP	IN	_	_	_	_	_
16	transfection	transfection	NOUN	NN	Number=Sing	_	_	_	_
17	with	with	ADP	IN	_	_	_	_	_
18	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
19	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
20	CIITA	CIITA	PROPN	NNP	Number=Sing	_	_	_	_
21	cDNA	cDNA	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
22	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 907
# text = These data indicate that the expression of CIITA explains the expression or lack of expression of MHC class II in human and mouse T cells respectively.
1	These	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
2	data	data	NOUN	NN	Number=Sing	_	_	_	_
3	indicate	indicate	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
4	that	that	SCONJ	IN	_	_	_	_	_
5	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
6	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
7	of	of	ADP	IN	_	_	_	_	_
8	CIITA	CIITA	PROPN	NNP	Number=Sing	_	_	_	_
9	explains	explain	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
10	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
11	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
12	or	or	CCONJ	CC	_	_	_	_	_
13	lack	lack	NOUN	NN	Number=Sing	_	_	_	_
14	of	of	ADP	IN	_	_	_	_	_
15	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
16	of	of	ADP	IN	_	_	_	_	_
17	MHC	MHC	PROPN	NNP	Number=Sing	_	_	_	_
18	class	class	NOUN	NN	Number=Sing	_	_	_	_
19	II	ii	NUM	CD	NumType=Card	_	_	_	_
20	in	in	ADP	IN	_	_	_	_	_
21	human	human	NOUN	NN	Number=Sing	_	_	_	_
22	and	and	CCONJ	CC	_	_	_	_	_
23	mouse	mouse	NOUN	NN	Number=Sing	_	_	_	_
24	T	t	PROPN	NNP	Number=Sing	_	_	_	_
25	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
26	respectively	respectively	ADV	RB	_	_	_	_	SpaceAfter=No
27	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 908
# text = Document 003002330 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	003002330	003002330	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 909
# text = Silencing of human fetal globin expression is impaired in the absence of the adult beta-globin gene activator protein EKLF.
1	Silencing	Silencing	NOUN	NN	Number=Sing	_	_	_	_
2	of	of	ADP	IN	_	_	_	_	_
3	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
4	fetal	fetal	ADJ	JJ	Degree=Pos	_	_	_	_
5	globin	globin	NOUN	NN	Number=Sing	_	_	_	_
6	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
7	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
8	impaired	impaire	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
9	in	in	ADP	IN	_	_	_	_	_
10	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
11	absence	absence	NOUN	NN	Number=Sing	_	_	_	_
12	of	of	ADP	IN	_	_	_	_	_
13	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
14	adult	adult	NOUN	NN	Number=Sing	_	_	_	_
15	beta	beta	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
16	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
17	globin	globin	NOUN	NN	Number=Sing	_	_	_	_
18	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
19	activator	activator	NOUN	NN	Number=Sing	_	_	_	_
20	protein	protein	NOUN	NN	Number=Sing	_	_	_	_
21	EKLF	Eklf	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
22	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 910
# text = Globin genes are subject to tissue-specific and developmental stage-specific regulation.
1	Globin	Globin	ADJ	JJ	Degree=Pos	_	_	_	_
2	genes	gene	NOUN	NNS	Number=Plur	_	_	_	_
3	are	be	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
4	subject	subject	ADJ	JJ	Degree=Pos	_	_	_	_
5	to	to	ADP	IN	_	_	_	_	_
6	tissue	tissue	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
7	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
8	specific	specific	ADJ	JJ	Degree=Pos	_	_	_	_
9	and	and	CCONJ	CC	_	_	_	_	_
10	developmental	developmental	ADJ	JJ	Degree=Pos	_	_	_	_
11	stage	stage	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
12	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
13	specific	specific	ADJ	JJ	Degree=Pos	_	_	_	_
14	regulation	regulation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
15	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 911
# text = A switch from human fetal (gamma)-to adult (beta)-globin expression occurs within erythroid precursor cells of the adult lineage.
1	A	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
2	switch	switch	NOUN	NN	Number=Sing	_	_	_	_
3	from	from	ADP	IN	_	_	_	_	_
4	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
5	fetal	fetal	NOUN	NN	Number=Sing	_	_	_	_
6	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
7	gamma	gamma	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
8	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
9	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
10	to	to	ADP	IN	_	_	_	_	_
11	adult	adult	NOUN	NN	Number=Sing	_	_	_	_
12	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
13	beta	beta	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
14	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
15	-	-	PUNCT	:	_	_	_	_	SpaceAfter=No
16	globin	globin	ADJ	JJ	Degree=Pos	_	_	_	_
17	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
18	occurs	occur	NOUN	NNS	Number=Plur	_	_	_	_
19	within	within	ADP	IN	_	_	_	_	_
20	erythroid	erythroid	ADJ	JJ	Degree=Pos	_	_	_	_
21	precursor	precursor	ADJ	JJ	Degree=Pos	_	_	_	_
22	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
23	of	of	ADP	IN	_	_	_	_	_
24	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
25	adult	adult	ADJ	JJ	Degree=Pos	_	_	_	_
26	lineage	lineage	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
27	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 912
# text = Previously we and others showed by targeted gene disruption that the zinc finger gene, erythroid Kruppel-like factor (EKLF), is required for expression of the beta-globin gene in mice, presumably through interaction with a high-affinity binding site in the proximal promoter.
1	Previously	previously	ADV	RB	_	_	_	_	_
2	we	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
3	and	and	CCONJ	CC	_	_	_	_	_
4	others	other	NOUN	NNS	Number=Plur	_	_	_	_
5	showed	show	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
6	by	by	ADP	IN	_	_	_	_	_
7	targeted	target	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
8	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
9	disruption	disruption	NOUN	NN	Number=Sing	_	_	_	_
10	that	that	SCONJ	IN	_	_	_	_	_
11	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
12	zinc	zinc	NOUN	NN	Number=Sing	_	_	_	_
13	finger	finger	NOUN	NN	Number=Sing	_	_	_	_
14	gene	gene	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
15	,	,	PUNCT	,	_	_	_	_	_
16	erythroid	erythroid	PROPN	NNP	Number=Sing	_	_	_	_
17	Kruppel	Kruppel	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
18	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
19	like	like	ADJ	JJ	Degree=Pos	_	_	_	_
20	factor	factor	NOUN	NN	Number=Sing	_	_	_	_
21	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
22	EKLF	EKLF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
23	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
24	,	,	PUNCT	,	_	_	_	_	_
25	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
26	required	require	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
27	for	for	ADP	IN	_	_	_	_	_
28	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
29	of	of	ADP	IN	_	_	_	_	_
30	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
31	beta	beta	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
32	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
33	globin	globin	NOUN	NN	Number=Sing	_	_	_	_
34	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
35	in	in	ADP	IN	_	_	_	_	_
36	mice	mouse	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
37	,	,	PUNCT	,	_	_	_	_	_
38	presumably	presumably	ADV	RB	_	_	_	_	_
39	through	through	ADP	IN	_	_	_	_	_
40	interaction	interaction	NOUN	NN	Number=Sing	_	_	_	_
41	with	with	ADP	IN	_	_	_	_	_
42	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
43	high	high	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
44	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
45	affinity	affinity	NOUN	NN	Number=Sing	_	_	_	_
46	binding	binding	VERB	VBG	VerbForm=Ger	_	_	_	_
47	site	site	NOUN	NN	Number=Sing	_	_	_	_
48	in	in	ADP	IN	_	_	_	_	_
49	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
50	proximal	proximal	ADJ	JJ	Degree=Pos	_	_	_	_
51	promoter	promoter	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
52	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 913
# text = To examine the role of EKLF in the developmental regulation of the human gamma-globin gene we interbred EKLF heterozygotes (+/-) with mice harboring a human beta-globin yeast artificial chromosome transgene.
1	To	to	PART	TO	_	_	_	_	_
2	examine	examine	VERB	VB	VerbForm=Inf	_	_	_	_
3	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
4	role	role	NOUN	NN	Number=Sing	_	_	_	_
5	of	of	ADP	IN	_	_	_	_	_
6	EKLF	EKLF	PROPN	NNP	Number=Sing	_	_	_	_
7	in	in	ADP	IN	_	_	_	_	_
8	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
9	developmental	developmental	ADJ	JJ	Degree=Pos	_	_	_	_
10	regulation	regulation	NOUN	NN	Number=Sing	_	_	_	_
11	of	of	ADP	IN	_	_	_	_	_
12	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
13	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
14	gamma	gamma	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
15	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
16	globin	globin	NOUN	NN	Number=Sing	_	_	_	_
17	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
18	we	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
19	interbred	interbr	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
20	EKLF	EKLF	PROPN	NNP	Number=Sing	_	_	_	_
21	heterozygotes	heterozygote	NOUN	NNS	Number=Plur	_	_	_	_
22	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
23	+/-)	+/-)	SYM	NFP	_	_	_	_	_
24	with	with	ADP	IN	_	_	_	_	_
25	mice	mouse	NOUN	NNS	Number=Plur	_	_	_	_
26	harboring	harbor	VERB	VBG	VerbForm=Ger	_	_	_	_
27	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
28	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
29	beta	beta	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
30	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
31	globin	globin	NOUN	NN	Number=Sing	_	_	_	_
32	yeast	yeast	NOUN	NN	Number=Sing	_	_	_	_
33	artificial	artificial	ADJ	JJ	Degree=Pos	_	_	_	_
34	chromosome	chromosome	ADJ	JJ	Degree=Pos	_	_	_	_
35	transgene	transgene	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
36	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 914
# text = We find that in the absence of EKLF, while human beta-globin expression is dramatically reduced, gamma-globin transcripts are elevated approximately 5-fold.
1	We	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
2	find	find	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
3	that	that	PRON	DT	Number=Sing|PronType=Dem	_	_	_	_
4	in	in	ADP	IN	_	_	_	_	_
5	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
6	absence	absence	NOUN	NN	Number=Sing	_	_	_	_
7	of	of	ADP	IN	_	_	_	_	_
8	EKLF	EKLF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
9	,	,	PUNCT	,	_	_	_	_	_
10	while	while	SCONJ	IN	_	_	_	_	_
11	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
12	beta	beta	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
13	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
14	globin	globin	NOUN	NN	Number=Sing	_	_	_	_
15	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
16	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
17	dramatically	dramatically	ADV	RB	_	_	_	_	_
18	reduced	reduce	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	SpaceAfter=No
19	,	,	PUNCT	,	_	_	_	_	_
20	gamma	gamma	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
21	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
22	globin	globin	NOUN	NN	Number=Sing	_	_	_	_
23	transcripts	transcript	NOUN	NNS	Number=Plur	_	_	_	_
24	are	be	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
25	elevated	elevate	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
26	approximately	approximately	ADV	RB	_	_	_	_	_
27	5	5	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
28	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
29	fold	fold	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
30	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 915
# text = Impaired silencing of gamma-globin expression identifies EKLF as the first transcription factor participating quantitatively in the gamma-globin to beta-globin switch.
1	Impaired	Impaired	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
2	silencing	silencing	NOUN	NN	Number=Sing	_	_	_	_
3	of	of	ADP	IN	_	_	_	_	_
4	gamma	gamma	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
5	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
6	globin	globin	NOUN	NN	Number=Sing	_	_	_	_
7	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
8	identifies	identify	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
9	EKLF	EKLF	PROPN	NNP	Number=Sing	_	_	_	_
10	as	as	ADP	IN	_	_	_	_	_
11	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
12	first	first	ADJ	JJ	Degree=Pos|NumType=Ord	_	_	_	_
13	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
14	factor	factor	NOUN	NN	Number=Sing	_	_	_	_
15	participating	participate	VERB	VBG	VerbForm=Ger	_	_	_	_
16	quantitatively	quantitatively	ADV	RB	_	_	_	_	_
17	in	in	ADP	IN	_	_	_	_	_
18	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
19	gamma	gamma	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
20	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
21	globin	globin	NOUN	NN	Number=Sing	_	_	_	_
22	to	to	ADP	IN	_	_	_	_	_
23	beta	beta	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
24	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
25	globin	globin	ADJ	JJ	Degree=Pos	_	_	_	_
26	switch	switch	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
27	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 916
# text = Our findings are compatible with a competitive model of switching in which EKLF mediates an adult stage-specific interaction between the beta-globin gene promoter and the locus control region that excludes the gamma-globin gene.
1	Our	we	PRON	PRP$	Number=Plur|Person=1|Poss=Yes|PronType=Prs	_	_	_	_
2	findings	finding	NOUN	NNS	Number=Plur	_	_	_	_
3	are	be	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
4	compatible	compatible	ADJ	JJ	Degree=Pos	_	_	_	_
5	with	with	ADP	IN	_	_	_	_	_
6	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
7	competitive	competitive	ADJ	JJ	Degree=Pos	_	_	_	_
8	model	model	NOUN	NN	Number=Sing	_	_	_	_
9	of	of	SCONJ	IN	_	_	_	_	_
10	switching	switch	VERB	VBG	VerbForm=Ger	_	_	_	_
11	in	in	ADP	IN	_	_	_	_	_
12	which	which	PRON	WDT	PronType=Rel	_	_	_	_
13	EKLF	EKLF	PROPN	NNP	Number=Sing	_	_	_	_
14	mediates	mediate	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
15	an	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
16	adult	adult	ADJ	JJ	Degree=Pos	_	_	_	_
17	stage	stage	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
18	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
19	specific	specific	ADJ	JJ	Degree=Pos	_	_	_	_
20	interaction	interaction	NOUN	NN	Number=Sing	_	_	_	_
21	between	between	ADP	IN	_	_	_	_	_
22	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
23	beta	beta	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
24	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
25	globin	globin	NOUN	NN	Number=Sing	_	_	_	_
26	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
27	promoter	promoter	NOUN	NN	Number=Sing	_	_	_	_
28	and	and	CCONJ	CC	_	_	_	_	_
29	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
30	locus	locus	ADJ	JJ	Degree=Pos	_	_	_	_
31	control	control	NOUN	NN	Number=Sing	_	_	_	_
32	region	region	NOUN	NN	Number=Sing	_	_	_	_
33	that	that	PRON	WDT	PronType=Rel	_	_	_	_
34	excludes	exclude	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
35	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
36	gamma	gamma	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
37	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
38	globin	globin	NOUN	NN	Number=Sing	_	_	_	_
39	gene	gene	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
40	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 917
# text = Document 003002336 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	003002336	003002336	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 918
# text = Membrane-associated lymphotoxin on natural killer cells activates endothelial cells via an NF-kappaB-dependent pathway.
1	Membrane	membrane	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
2	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
3	associated	associate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
4	lymphotoxin	lymphotoxin	NOUN	NN	Number=Sing	_	_	_	_
5	on	on	ADP	IN	_	_	_	_	_
6	natural	natural	ADJ	JJ	Degree=Pos	_	_	_	_
7	killer	killer	NOUN	NN	Number=Sing	_	_	_	_
8	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
9	activates	activate	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
10	endothelial	endothelial	ADJ	JJ	Degree=Pos	_	_	_	_
11	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
12	via	via	ADP	IN	_	_	_	_	_
13	an	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
14	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
15	-kappaB	-kappab	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
16	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
17	dependent	dependent	ADJ	JJ	Degree=Pos	_	_	_	_
18	pathway	pathway	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
19	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 919
# text = BACKGROUND:
1	BACKGROUND	background	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
2	:	:	PUNCT	:	_	_	_	_	_

# sent_id = 920
# text = Inhibition of complement in small animal models of xenotransplantation has demonstrated graft infiltration with natural killer (NK) cells and monocytes associated with endothelial cell (EC) activation.
1	Inhibition	Inhibition	NOUN	NN	Number=Sing	_	_	_	_
2	of	of	ADP	IN	_	_	_	_	_
3	complement	complement	NOUN	NN	Number=Sing	_	_	_	_
4	in	in	ADP	IN	_	_	_	_	_
5	small	small	ADJ	JJ	Degree=Pos	_	_	_	_
6	animal	animal	NOUN	NN	Number=Sing	_	_	_	_
7	models	model	NOUN	NNS	Number=Plur	_	_	_	_
8	of	of	ADP	IN	_	_	_	_	_
9	xenotransplantation	xenotransplantation	NOUN	NN	Number=Sing	_	_	_	_
10	has	have	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
11	demonstrated	demonstrate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
12	graft	graft	NOUN	NN	Number=Sing	_	_	_	_
13	infiltration	infiltration	NOUN	NN	Number=Sing	_	_	_	_
14	with	with	ADP	IN	_	_	_	_	_
15	natural	natural	ADJ	JJ	Degree=Pos	_	_	_	_
16	killer	killer	NOUN	NN	Number=Sing	_	_	_	_
17	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
18	NK	NK	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
19	)	)	PUNCT	-RRB-	_	_	_	_	_
20	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
21	and	and	CCONJ	CC	_	_	_	_	_
22	monocytes	monocyte	NOUN	NNS	Number=Plur	_	_	_	_
23	associated	associate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
24	with	with	ADP	IN	_	_	_	_	_
25	endothelial	endothelial	ADJ	JJ	Degree=Pos	_	_	_	_
26	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
27	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
28	EC	EC	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
29	)	)	PUNCT	-RRB-	_	_	_	_	_
30	activation	activation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
31	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 921
# text = We have previously demonstrated that human NK cells activate porcine EC in vitro, which results in adhesion molecule expression and cytokine secretion.
1	We	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
2	have	have	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
3	previously	previously	ADV	RB	_	_	_	_	_
4	demonstrated	demonstrate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
5	that	that	SCONJ	IN	_	_	_	_	_
6	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
7	NK	Nk	PROPN	NNP	Number=Sing	_	_	_	_
8	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
9	activate	activate	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
10	porcine	porcine	PRON	PRP	_	_	_	_	_
11	EC	EC	PROPN	NNP	Number=Sing	_	_	_	_
12	in	in	ADP	IN	_	_	_	_	_
13	vitro	vitro	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
14	,	,	PUNCT	,	_	_	_	_	_
15	which	which	DET	WDT	PronType=Int	_	_	_	_
16	results	result	NOUN	NNS	Number=Plur	_	_	_	_
17	in	in	ADP	IN	_	_	_	_	_
18	adhesion	adhesion	NOUN	NN	Number=Sing	_	_	_	_
19	molecule	molecule	NOUN	NN	Number=Sing	_	_	_	_
20	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
21	and	and	CCONJ	CC	_	_	_	_	_
22	cytokine	cytokine	NOUN	NN	Number=Sing	_	_	_	_
23	secretion	secretion	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
24	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 922
# text = In this study, we used the NK cell line NK92 to define the molecular and cellular basis of NK cell-mediated EC activation.
1	In	in	ADP	IN	_	_	_	_	_
2	this	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
3	study	study	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
4	,	,	PUNCT	,	_	_	_	_	_
5	we	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
6	used	use	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
7	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
8	NK	NK	PROPN	NNP	Number=Sing	_	_	_	_
9	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
10	line	line	NOUN	NN	Number=Sing	_	_	_	_
11	NK92	Nk92	NOUN	NN	Number=Sing	_	_	_	_
12	to	to	PART	TO	_	_	_	_	_
13	define	define	VERB	VB	VerbForm=Inf	_	_	_	_
14	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
15	molecular	molecular	ADJ	JJ	Degree=Pos	_	_	_	_
16	and	and	CCONJ	CC	_	_	_	_	_
17	cellular	cellular	ADJ	JJ	Degree=Pos	_	_	_	_
18	basis	basis	NOUN	NN	Number=Sing	_	_	_	_
19	of	of	ADP	IN	_	_	_	_	_
20	NK	NK	PROPN	NNP	Number=Sing	_	_	_	_
21	cell	cell	ADV	RB	Degree=Pos	_	_	_	SpaceAfter=No
22	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
23	mediated	mediate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
24	EC	Ec	PROPN	NNP	Number=Sing	_	_	_	_
25	activation	activation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
26	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 923
# text = METHODS: EC were transfected with either reporter constructs containing the luciferase gene driven either by E-selectin or interleukin (IL)-8 promoters or a synthetic NF-kappaB-dependent promoter.
1	METHODS	method	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
2	:	:	PUNCT	:	_	_	_	_	_
3	EC	Ec	PROPN	NNP	Number=Sing	_	_	_	_
4	were	be	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
5	transfected	transfect	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
6	with	with	ADP	IN	_	_	_	_	_
7	either	either	DET	DT	_	_	_	_	_
8	reporter	reporter	NOUN	NN	Number=Sing	_	_	_	_
9	constructs	construct	NOUN	NNS	Number=Plur	_	_	_	_
10	containing	contain	VERB	VBG	VerbForm=Ger	_	_	_	_
11	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
12	luciferase	luciferase	NOUN	NN	Number=Sing	_	_	_	_
13	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
14	driven	drive	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
15	either	either	CCONJ	CC	_	_	_	_	_
16	by	by	ADP	IN	_	_	_	_	_
17	E-	e-	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
18	selectin	selectin	NOUN	NN	Number=Sing	_	_	_	_
19	or	or	CCONJ	CC	_	_	_	_	_
20	interleukin	interleukin	NOUN	NN	Number=Sing	_	_	_	_
21	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
22	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
23	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
24	-	-	SYM	SYM	_	_	_	_	SpaceAfter=No
25	8	8	NUM	CD	NumType=Card	_	_	_	_
26	promoters	promoter	NOUN	NNS	Number=Plur	_	_	_	_
27	or	or	CCONJ	CC	_	_	_	_	_
28	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
29	synthetic	synthetic	ADJ	JJ	Degree=Pos	_	_	_	_
30	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
31	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
32	kappaB	kappaB	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
33	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
34	dependent	dependent	ADJ	JJ	Degree=Pos	_	_	_	_
35	promoter	promoter	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
36	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 924
# text = In addition, a dominant-negative mutant tumor necrosis factor receptor
1	In	in	ADP	IN	_	_	_	_	_
2	addition	addition	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
3	,	,	PUNCT	,	_	_	_	_	_
4	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
5	dominant	dominant	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
6	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
7	negative	negative	ADJ	JJ	Degree=Pos	_	_	_	_
8	mutant	mutant	ADJ	JJ	Degree=Pos	_	_	_	_
9	tumor	tumor	NOUN	NN	Number=Sing	_	_	_	_
10	necrosis	necrosis	NOUN	NN	Number=Sing	_	_	_	_
11	factor	factor	NOUN	NN	Number=Sing	_	_	_	_
12	receptor	receptor	NOUN	NN	Number=Sing	_	_	_	_

# sent_id = 925
# text = I (TNFRI) expression vector was co-transfected in inhibition studies.
1	I	I	PRON	PRP	Case=Nom|Number=Sing|Person=1|PronType=Prs	_	_	_	_
2	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
3	TNFRI	TNFRI	X	AFX	_	_	_	_	SpaceAfter=No
4	)	)	PUNCT	-RRB-	_	_	_	_	_
5	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
6	vector	vector	NOUN	NN	Number=Sing	_	_	_	_
7	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
8	co-transfected	co-transfect	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
9	in	in	ADP	IN	_	_	_	_	_
10	inhibition	inhibition	NOUN	NN	Number=Sing	_	_	_	_
11	studies	study	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
12	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 926
# text = Forty-eight hours after transfection, EC were stimulated with NK cells or NK cell membrane extracts for 7 hr and activation was measured by a luciferase assay.
1	Forty	Forty	INTJ	UH	_	_	_	_	SpaceAfter=No
2	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
3	eight	eight	NUM	CD	NumType=Card	_	_	_	_
4	hours	hour	NOUN	NNS	Number=Plur	_	_	_	_
5	after	after	ADP	IN	_	_	_	_	_
6	transfection	transfection	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
7	,	,	PUNCT	,	_	_	_	_	_
8	EC	EC	PROPN	NNP	Number=Sing	_	_	_	_
9	were	be	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
10	stimulated	stimulate	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
11	with	with	ADP	IN	_	_	_	_	_
12	NK	NK	PROPN	NNP	Number=Sing	_	_	_	_
13	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
14	or	or	CCONJ	CC	_	_	_	_	_
15	NK	NK	PROPN	NNP	Number=Sing	_	_	_	_
16	cell	cell	VERB	VB	VerbForm=Inf	_	_	_	_
17	membrane	membrane	NOUN	NN	Number=Sing	_	_	_	_
18	extracts	extract	NOUN	NNS	Number=Plur	_	_	_	_
19	for	for	ADP	IN	_	_	_	_	_
20	7	7	NUM	CD	NumType=Card	_	_	_	_
21	hr	hr	NOUN	NN	Number=Sing	_	_	_	_
22	and	and	CCONJ	CC	_	_	_	_	_
23	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
24	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
25	measured	measure	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
26	by	by	ADP	IN	_	_	_	_	_
27	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
28	luciferase	luciferase	NOUN	NN	Number=Sing	_	_	_	_
29	assay	assay	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
30	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 927
# text = RESULTS: Co-culture of NK cells with transfected EC enhanced E-selectin, IL-8, and NF-kappaB-dependent promoter activity.
1	RESULTS	result	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
2	:	:	PUNCT	:	_	_	_	_	_
3	Co-culture	Co-culture	NOUN	NN	Number=Sing	_	_	_	_
4	of	of	ADP	IN	_	_	_	_	_
5	NK	NK	PROPN	NNP	Number=Sing	_	_	_	_
6	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
7	with	with	ADP	IN	_	_	_	_	_
8	transfected	transfect	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
9	EC	Ec	PROPN	NNP	Number=Sing	_	_	_	_
10	enhanced	enhance	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
11	E-selectin	E-selectin	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
12	,	,	PUNCT	,	_	_	_	_	_
13	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
14	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
15	8	8	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
16	,	,	PUNCT	,	_	_	_	_	_
17	and	and	CCONJ	CC	_	_	_	_	_
18	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
19	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
20	kappaB	kappaB	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
21	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
22	dependent	dependent	ADJ	JJ	Degree=Pos	_	_	_	_
23	promoter	promoter	NOUN	NN	Number=Sing	_	_	_	_
24	activity	activity	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
25	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 928
# text = NK cell membrane extracts retained the capacity to activate EC and induced nuclear translocation of NF-kappaB (p50 and p65).
1	NK	NK	PROPN	NNP	Number=Sing	_	_	_	_
2	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
3	membrane	membrane	NOUN	NN	Number=Sing	_	_	_	_
4	extracts	extract	NOUN	NNS	Number=Plur	_	_	_	_
5	retained	retain	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
6	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
7	capacity	capacity	NOUN	NN	Number=Sing	_	_	_	_
8	to	to	PART	TO	_	_	_	_	_
9	activate	activate	VERB	VB	VerbForm=Inf	_	_	_	_
10	EC	EC	PROPN	NNP	Number=Sing	_	_	_	_
11	and	and	CCONJ	CC	_	_	_	_	_
12	induced	induce	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
13	nuclear	nuclear	ADJ	JJ	Degree=Pos	_	_	_	_
14	translocation	translocation	NOUN	NN	Number=Sing	_	_	_	_
15	of	of	ADP	IN	_	_	_	_	_
16	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
17	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
18	kappaB	kappaB	PROPN	NNP	Number=Sing	_	_	_	_
19	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
20	p50	p50	NUM	CD	NumType=Card	_	_	_	_
21	and	and	CCONJ	CC	_	_	_	_	_
22	p65	p65	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
23	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
24	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 929
# text = Western blotting of NK cell and membrane extracts detected the presence of Lymphotoxin-alpha (LTalpha) but not tumor necrosis factor-alpha.
1	Western	western	ADJ	JJ	Degree=Pos	_	_	_	_
2	blotting	blotting	NOUN	NN	Number=Sing	_	_	_	_
3	of	of	ADP	IN	_	_	_	_	_
4	NK	NK	PROPN	NNP	Number=Sing	_	_	_	_
5	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
6	and	and	CCONJ	CC	_	_	_	_	_
7	membrane	membrane	NOUN	NN	Number=Sing	_	_	_	_
8	extracts	extract	NOUN	NNS	Number=Plur	_	_	_	_
9	detected	detect	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
10	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
11	presence	presence	NOUN	NN	Number=Sing	_	_	_	_
12	of	of	ADP	IN	_	_	_	_	_
13	Lymphotoxin	Lymphotoxin	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
14	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
15	alpha	alpha	PROPN	NNP	Number=Sing	_	_	_	_
16	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
17	LTalpha	LTalpha	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
18	)	)	PUNCT	-RRB-	_	_	_	_	_
19	but	but	CCONJ	CC	_	_	_	_	_
20	not	not	ADV	RB	_	_	_	_	_
21	tumor	tumor	ADP	IN	_	_	_	_	_
22	necrosis	necrosis	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
23	factor	factor	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
24	-alpha	-alpha	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
25	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 930
# text = Furthermore, LTalpha was secreted in NK:EC co-cultures.
1	Furthermore	furthermore	ADV	RB	_	_	_	_	SpaceAfter=No
2	,	,	PUNCT	,	_	_	_	_	_
3	LTalpha	LTalpha	PROPN	NNP	Number=Sing	_	_	_	_
4	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
5	secreted	secret	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
6	in	in	ADP	IN	_	_	_	_	_
7	NK:EC	Nk:ec	PROPN	NNP	Number=Sing	_	_	_	_
8	co-cultures	co-culture	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
9	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 931
# text = Co-transfection with dominant-negative mutant TNFRI inhibited EC activation by NK cell membrane extracts and by NK cells by 80% and 47%, respectively.
1	Co-transfection	Co-transfection	NOUN	NN	Number=Sing	_	_	_	_
2	with	with	ADP	IN	_	_	_	_	_
3	dominant	dominant	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
4	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
5	negative	negative	ADJ	JJ	Degree=Pos	_	_	_	_
6	mutant	mutant	NOUN	NN	Number=Sing	_	_	_	_
7	TNFRI	Tnfri	PRON	PRP	Case=Nom|Number=Sing|Person=1|PronType=Prs	_	_	_	_
8	inhibited	inhibit	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
9	EC	Ec	PROPN	NNP	Number=Sing	_	_	_	_
10	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
11	by	by	ADP	IN	_	_	_	_	_
12	NK	NK	PROPN	NNP	Number=Sing	_	_	_	_
13	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
14	membrane	membrane	NOUN	NN	Number=Sing	_	_	_	_
15	extracts	extract	NOUN	NNS	Number=Plur	_	_	_	_
16	and	and	CCONJ	CC	_	_	_	_	_
17	by	by	ADP	IN	_	_	_	_	_
18	NK	NK	PROPN	NNP	Number=Sing	_	_	_	_
19	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
20	by	by	ADP	IN	_	_	_	_	_
21	80	80	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
22	%	%	SYM	NN	Number=Sing	_	_	_	_
23	and	and	CCONJ	CC	_	_	_	_	_
24	47	47	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
25	%	%	SYM	NN	Number=Sing	_	_	_	SpaceAfter=No
26	,	,	PUNCT	,	_	_	_	_	_
27	respectively	respectively	ADV	RB	_	_	_	_	SpaceAfter=No
28	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 932
# text = The same pattern of inhibition was observed using anti-human LT sera.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	same	same	ADJ	JJ	Degree=Pos	_	_	_	_
3	pattern	pattern	NOUN	NN	Number=Sing	_	_	_	_
4	of	of	ADP	IN	_	_	_	_	_
5	inhibition	inhibition	NOUN	NN	Number=Sing	_	_	_	_
6	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
7	observed	observe	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
8	using	use	VERB	VBG	VerbForm=Ger	_	_	_	_
9	anti-human	anti-human	ADJ	JJ	Degree=Pos	_	_	_	_
10	LT	Lt	NOUN	NN	Number=Sing	_	_	_	_
11	sera	sera	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
12	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 933
# text = CONCLUSIONS: Human NK cell membrane-bound LT signals across species via TNFRI, leading to NF-kappaB nuclear translocation and transcription of E-selectin and IL-8, which results in EC activation.
1	CONCLUSIONS	conclusion	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
2	:	:	PUNCT	:	_	_	_	_	_
3	Human	human	ADJ	JJ	Degree=Pos	_	_	_	_
4	NK	NK	PROPN	NNP	Number=Sing	_	_	_	_
5	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
6	membrane	membrane	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
7	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
8	bound	bound	ADJ	JJ	Degree=Pos	_	_	_	_
9	LT	Lt	NOUN	NN	Number=Sing	_	_	_	_
10	signals	signal	NOUN	NNS	Number=Plur	_	_	_	_
11	across	across	ADP	IN	_	_	_	_	_
12	species	species	NOUN	NNS	Number=Plur	_	_	_	_
13	via	via	ADP	IN	_	_	_	_	_
14	TNFRI	TNFRI	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
15	,	,	PUNCT	,	_	_	_	_	_
16	leading	lead	VERB	VBG	VerbForm=Ger	_	_	_	_
17	to	to	ADP	IN	_	_	_	_	_
18	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
19	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
20	kappaB	kappaB	PROPN	NNP	Number=Sing	_	_	_	_
21	nuclear	nuclear	ADJ	JJ	Degree=Pos	_	_	_	_
22	translocation	translocation	NOUN	NN	Number=Sing	_	_	_	_
23	and	and	CCONJ	CC	_	_	_	_	_
24	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
25	of	of	ADP	IN	_	_	_	_	_
26	E-	e-	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
27	selectin	selectin	NOUN	NN	Number=Sing	_	_	_	_
28	and	and	CCONJ	CC	_	_	_	_	_
29	IL	Il	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
30	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
31	8	8	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
32	,	,	PUNCT	,	_	_	_	_	_
33	which	which	DET	WDT	PronType=Int	_	_	_	_
34	results	result	NOUN	NNS	Number=Plur	_	_	_	_
35	in	in	ADP	IN	_	_	_	_	_
36	EC	EC	PROPN	NNP	Number=Sing	_	_	_	_
37	activation	activation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
38	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 934
# text = The discrepancy in the degree of inhibition by membrane extracts and NK cells with mutant TNFRI suggests that additional pathways are utilized by NK cells to activate EC.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	discrepancy	discrepancy	NOUN	NN	Number=Sing	_	_	_	_
3	in	in	ADP	IN	_	_	_	_	_
4	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
5	degree	degree	NOUN	NN	Number=Sing	_	_	_	_
6	of	of	ADP	IN	_	_	_	_	_
7	inhibition	inhibition	NOUN	NN	Number=Sing	_	_	_	_
8	by	by	ADP	IN	_	_	_	_	_
9	membrane	membrane	ADJ	JJ	Degree=Pos	_	_	_	_
10	extracts	extract	NOUN	NNS	Number=Plur	_	_	_	_
11	and	and	CCONJ	CC	_	_	_	_	_
12	NK	NK	PROPN	NNP	Number=Sing	_	_	_	_
13	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
14	with	with	ADP	IN	_	_	_	_	_
15	mutant	mutant	ADJ	JJ	Degree=Pos	_	_	_	_
16	TNFRI	TNFRI	PROPN	NNP	Number=Sing	_	_	_	_
17	suggests	suggest	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
18	that	that	SCONJ	IN	_	_	_	_	_
19	additional	additional	ADJ	JJ	Degree=Pos	_	_	_	_
20	pathways	pathway	NOUN	NNS	Number=Plur	_	_	_	_
21	are	be	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
22	utilized	utilize	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
23	by	by	ADP	IN	_	_	_	_	_
24	NK	NK	PROPN	NNP	Number=Sing	_	_	_	_
25	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
26	to	to	PART	TO	_	_	_	_	_
27	activate	activate	VERB	VB	VerbForm=Inf	_	_	_	_
28	EC	EC	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
29	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 935
# text = Document 003002346 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	003002346	003002346	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 936
# text = NF-kappaB only partially mediates Epstein-Barr virus latent membrane protein 1 activation of B cells.
1	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
2	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
3	kappaB	kappaB	PROPN	NNP	Number=Sing	_	_	_	_
4	only	only	ADV	RB	_	_	_	_	_
5	partially	partially	ADV	RB	_	_	_	_	_
6	mediates	mediate	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
7	Epstein	Epstein	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
8	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
9	Barr	Barr	PROPN	NNP	Number=Sing	_	_	_	_
10	virus	virus	NOUN	NN	Number=Sing	_	_	_	_
11	latent	latent	ADJ	JJ	Degree=Pos	_	_	_	_
12	membrane	membrane	NOUN	NN	Number=Sing	_	_	_	_
13	protein	protein	NOUN	NN	Number=Sing	_	_	_	_
14	1	1	NUM	CD	NumType=Card	_	_	_	_
15	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
16	of	of	ADP	IN	_	_	_	_	_
17	B	b	ADJ	JJ	Degree=Pos	_	_	_	_
18	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
19	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 937
# text = The latent membrane protein 1 (LMP1) of Epstein-Barr virus (EBV) is required for EBV-induced immortalization of human B cells and causes tumorigenic transformation of cell lines.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	latent	latent	ADJ	JJ	Degree=Pos	_	_	_	_
3	membrane	membrane	NOUN	NN	Number=Sing	_	_	_	_
4	protein	protein	NOUN	NN	Number=Sing	_	_	_	_
5	1	1	NUM	CD	NumType=Card	_	_	_	_
6	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
7	LMP1	LMP1	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
8	)	)	PUNCT	-RRB-	_	_	_	_	_
9	of	of	ADP	IN	_	_	_	_	_
10	Epstein	Epstein	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
11	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
12	Barr	Barr	PROPN	NNP	Number=Sing	_	_	_	_
13	virus	virus	NOUN	NN	Number=Sing	_	_	_	_
14	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
15	EBV	EBV	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
16	)	)	PUNCT	-RRB-	_	_	_	_	_
17	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
18	required	require	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
19	for	for	ADP	IN	_	_	_	_	_
20	EBV	EBV	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
21	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
22	induced	induce	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
23	immortalization	immortalization	NOUN	NN	Number=Sing	_	_	_	_
24	of	of	ADP	IN	_	_	_	_	_
25	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
26	B	b	ADJ	JJ	Degree=Pos	_	_	_	_
27	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
28	and	and	CCONJ	CC	_	_	_	_	_
29	causes	cause	NOUN	NNS	Number=Plur	_	_	_	_
30	tumorigenic	tumorigenic	ADJ	JJ	Degree=Pos	_	_	_	_
31	transformation	transformation	NOUN	NN	Number=Sing	_	_	_	_
32	of	of	ADP	IN	_	_	_	_	_
33	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
34	lines	line	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
35	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 938
# text = LMP1 expression induces phenotypic changes resembling B cell activation, such as cell size increase and up-regulation of cell surface activation markers.
1	LMP1	LMP1	NUM	CD	NumType=Card	_	_	_	_
2	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
3	induces	induce	NOUN	NNS	Number=Plur	_	_	_	_
4	phenotypic	phenotypic	ADJ	JJ	Degree=Pos	_	_	_	_
5	changes	change	NOUN	NNS	Number=Plur	_	_	_	_
6	resembling	resembl	VERB	VBG	VerbForm=Ger	_	_	_	_
7	B	b	ADJ	JJ	Degree=Pos	_	_	_	_
8	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
9	activation	activation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
10	,	,	PUNCT	,	_	_	_	_	_
11	such	such	ADJ	JJ	Degree=Pos	_	_	_	_
12	as	as	ADP	IN	_	_	_	_	_
13	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
14	size	size	NOUN	NN	Number=Sing	_	_	_	_
15	increase	increase	NOUN	NN	Number=Sing	_	_	_	_
16	and	and	CCONJ	CC	_	_	_	_	_
17	up	up	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
18	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
19	regulation	regulation	NOUN	NN	Number=Sing	_	_	_	_
20	of	of	ADP	IN	_	_	_	_	_
21	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
22	surface	surface	NOUN	NN	Number=Sing	_	_	_	_
23	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
24	markers	marker	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
25	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 939
# text = LMP1 contains two domains that activate the transcription factor NF-kappaB, one through interactions with TRAF proteins and the other with the TRADD protein.
1	LMP1	LMP1	PROPN	NNP	Number=Sing	_	_	_	_
2	contains	contain	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
3	two	two	NUM	CD	NumType=Card	_	_	_	_
4	domains	domain	NOUN	NNS	Number=Plur	_	_	_	_
5	that	that	PRON	WDT	PronType=Rel	_	_	_	_
6	activate	activate	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
7	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
8	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
9	factor	factor	NOUN	NN	Number=Sing	_	_	_	_
10	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
11	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
12	kappaB	kappaB	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
13	,	,	PUNCT	,	_	_	_	_	_
14	one	one	NUM	CD	NumType=Card	_	_	_	_
15	through	through	ADP	IN	_	_	_	_	_
16	interactions	interaction	NOUN	NNS	Number=Plur	_	_	_	_
17	with	with	ADP	IN	_	_	_	_	_
18	TRAF	TRAF	NOUN	NN	Number=Sing	_	_	_	_
19	proteins	protein	NOUN	NNS	Number=Plur	_	_	_	_
20	and	and	CCONJ	CC	_	_	_	_	_
21	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
22	other	other	ADJ	JJ	Degree=Pos	_	_	_	_
23	with	with	ADP	IN	_	_	_	_	_
24	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
25	TRADD	tRADd	NOUN	NN	Number=Sing	_	_	_	_
26	protein	protein	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
27	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 940
# text = The purpose of the present study was to investigate the importance of NF-kappaB induction in the up-regulation of the B cell activation markers ICAM-1 and CD71 by LMP1.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	purpose	purpose	NOUN	NN	Number=Sing	_	_	_	_
3	of	of	ADP	IN	_	_	_	_	_
4	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
5	present	present	ADJ	JJ	Degree=Pos	_	_	_	_
6	study	study	NOUN	NN	Number=Sing	_	_	_	_
7	was	be	VERB	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
8	to	to	PART	TO	_	_	_	_	_
9	investigate	investigate	VERB	VB	VerbForm=Inf	_	_	_	_
10	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
11	importance	importance	NOUN	NN	Number=Sing	_	_	_	_
12	of	of	ADP	IN	_	_	_	_	_
13	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
14	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
15	kappaB	kappaB	PROPN	NNP	Number=Sing	_	_	_	_
16	induction	induction	NOUN	NN	Number=Sing	_	_	_	_
17	in	in	ADP	IN	_	_	_	_	_
18	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
19	up	up	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
20	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
21	regulation	regulation	NOUN	NN	Number=Sing	_	_	_	_
22	of	of	ADP	IN	_	_	_	_	_
23	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
24	B	b	ADJ	JJ	Degree=Pos	_	_	_	_
25	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
26	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
27	markers	marker	NOUN	NNS	Number=Plur	_	_	_	_
28	ICAM	ICAm	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
29	-	-	SYM	SYM	_	_	_	_	SpaceAfter=No
30	1	1	NUM	CD	NumType=Card	_	_	_	_
31	and	and	CCONJ	CC	_	_	_	_	_
32	CD71	CD71	PROPN	NNP	Number=Sing	_	_	_	_
33	by	by	ADP	IN	_	_	_	_	_
34	LMP1	LMP1	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
35	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 941
# text = This study shows that expression of LMP1 activates transcription from p50/p65- and c-Rel- responsive promoters, and that this activity can be completely inhibited by expression of a dominant inhibitory IkappaB mutant.
1	This	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
2	study	study	NOUN	NN	Number=Sing	_	_	_	_
3	shows	show	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
4	that	that	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
5	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
6	of	of	ADP	IN	_	_	_	_	_
7	LMP1	LMP1	NUM	CD	NumType=Card	_	_	_	_
8	activates	activate	NOUN	NNS	Number=Plur	_	_	_	_
9	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
10	from	from	ADP	IN	_	_	_	_	_
11	p50/p65-	p50/p65-	PUNCT	:	_	_	_	_	_
12	and	and	CCONJ	CC	_	_	_	_	_
13	c	c	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
14	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
15	Rel	Rel	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
16	-	-	PUNCT	HYPH	_	_	_	_	_
17	responsive	responsive	ADJ	JJ	Degree=Pos	_	_	_	_
18	promoters	promoter	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
19	,	,	PUNCT	,	_	_	_	_	_
20	and	and	CCONJ	CC	_	_	_	_	_
21	that	that	SCONJ	IN	_	_	_	_	_
22	this	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
23	activity	activity	NOUN	NN	Number=Sing	_	_	_	_
24	can	can	AUX	MD	VerbForm=Fin	_	_	_	_
25	be	be	AUX	VB	VerbForm=Inf	_	_	_	_
26	completely	completely	ADV	RB	_	_	_	_	_
27	inhibited	inhibit	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
28	by	by	ADP	IN	_	_	_	_	_
29	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
30	of	of	ADP	IN	_	_	_	_	_
31	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
32	dominant	dominant	ADJ	JJ	Degree=Pos	_	_	_	_
33	inhibitory	inhibitory	NOUN	NN	Number=Sing	_	_	_	_
34	IkappaB	Ikappab	NOUN	NN	Number=Sing	_	_	_	_
35	mutant	mutant	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
36	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 942
# text = ICAM-1 and CD71 are nevertheless up-regulated by LMP1 in primary B cells and cell lines expressing the dominant IkappaB.
1	ICAM	ICAm	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
2	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
3	1	1	NUM	CD	NumType=Card	_	_	_	_
4	and	and	CCONJ	CC	_	_	_	_	_
5	CD71	Cd71	PROPN	NNP	Number=Sing	_	_	_	_
6	are	be	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
7	nevertheless	nevertheless	ADV	RB	_	_	_	_	_
8	up	up	ADV	RB	_	_	_	_	SpaceAfter=No
9	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
10	regulated	regulate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
11	by	by	ADP	IN	_	_	_	_	_
12	LMP1	Lmp1	PROPN	NNP	Number=Sing	_	_	_	_
13	in	in	ADP	IN	_	_	_	_	_
14	primary	primary	ADJ	JJ	Degree=Pos	_	_	_	_
15	B	b	ADJ	JJ	Degree=Pos	_	_	_	_
16	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
17	and	and	CCONJ	CC	_	_	_	_	_
18	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
19	lines	line	NOUN	NNS	Number=Plur	_	_	_	_
20	expressing	expresse	VERB	VBG	VerbForm=Ger	_	_	_	_
21	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
22	dominant	dominant	ADJ	JJ	Degree=Pos	_	_	_	_
23	IkappaB	Ikappab	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
24	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 943
# text = Furthermore, LMP1-induced cell size increase of primary B cells was unaffected by IkappaB expression.
1	Furthermore	furthermore	ADV	RB	_	_	_	_	SpaceAfter=No
2	,	,	PUNCT	,	_	_	_	_	_
3	LMP1	LMP1	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
4	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
5	induced	induce	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
6	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
7	size	size	NOUN	NN	Number=Sing	_	_	_	_
8	increase	increase	NOUN	NN	Number=Sing	_	_	_	_
9	of	of	ADP	IN	_	_	_	_	_
10	primary	primary	ADJ	JJ	Degree=Pos	_	_	_	_
11	B	b	ADJ	JJ	Degree=Pos	_	_	_	_
12	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
13	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
14	unaffected	unaffected	ADJ	JJ	Degree=Pos	_	_	_	_
15	by	by	ADP	IN	_	_	_	_	_
16	IkappaB	Ikappab	PROPN	NNP	Number=Sing	_	_	_	_
17	expression	expression	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
18	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 944
# text = It was concluded that even when LMP1 is unable to activate NF-kappaB, it is still capable of inducing certain characteristics of activated B cells, strongly suggesting that LMP1 can also activate cells independently of NF-kappaB.
1	It	it	PRON	PRP	Case=Nom|Gender=Neut|Number=Sing|Person=3|PronType=Prs	_	_	_	_
2	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
3	concluded	conclude	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
4	that	that	SCONJ	IN	_	_	_	_	_
5	even	even	ADV	RB	_	_	_	_	_
6	when	when	ADV	WRB	PronType=Int	_	_	_	_
7	LMP1	LMP1	NUM	CD	NumType=Card	_	_	_	_
8	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
9	unable	unable	ADJ	JJ	Degree=Pos	_	_	_	_
10	to	to	PART	TO	_	_	_	_	_
11	activate	activate	VERB	VB	VerbForm=Inf	_	_	_	_
12	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
13	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
14	kappaB	kappaB	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
15	,	,	PUNCT	,	_	_	_	_	_
16	it	it	PRON	PRP	Case=Nom|Gender=Neut|Number=Sing|Person=3|PronType=Prs	_	_	_	_
17	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
18	still	still	ADV	RB	_	_	_	_	_
19	capable	capable	ADJ	JJ	Degree=Pos	_	_	_	_
20	of	of	SCONJ	IN	_	_	_	_	_
21	inducing	induce	VERB	VBG	VerbForm=Ger	_	_	_	_
22	certain	certain	ADJ	JJ	Degree=Pos	_	_	_	_
23	characteristics	characteristic	NOUN	NNS	Number=Plur	_	_	_	_
24	of	of	ADP	IN	_	_	_	_	_
25	activated	activate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
26	B	b	NOUN	NN	Number=Sing	_	_	_	_
27	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
28	,	,	PUNCT	,	_	_	_	_	_
29	strongly	strongly	ADV	RB	_	_	_	_	_
30	suggesting	suggest	VERB	VBG	VerbForm=Ger	_	_	_	_
31	that	that	SCONJ	IN	_	_	_	_	_
32	LMP1	LMP1	PROPN	NNP	Number=Sing	_	_	_	_
33	can	can	AUX	MD	VerbForm=Fin	_	_	_	_
34	also	also	ADV	RB	_	_	_	_	_
35	activate	activate	VERB	VB	VerbForm=Inf	_	_	_	_
36	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
37	independently	independently	ADV	RB	_	_	_	_	_
38	of	of	ADP	IN	_	_	_	_	_
39	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
40	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
41	kappaB.	kappaB.	PROPN	NNP	Number=Sing	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 945
# text = Document 003002347 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	003002347	003002347	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 946
# text = Potent gene regulatory and antiproliferative activities of 20-methyl analogues of 1,25 dihydroxyvitamin D3.
1	Potent	potent	ADJ	JJ	Degree=Pos	_	_	_	_
2	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
3	regulatory	regulatory	ADJ	JJ	Degree=Pos	_	_	_	_
4	and	and	CCONJ	CC	_	_	_	_	_
5	antiproliferative	antiproliferative	ADJ	JJ	Degree=Pos	_	_	_	_
6	activities	activity	NOUN	NNS	Number=Plur	_	_	_	_
7	of	of	ADP	IN	_	_	_	_	_
8	20	20	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
9	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
10	methyl	methyl	NOUN	NN	Number=Sing	_	_	_	_
11	analogues	analogue	NOUN	NNS	Number=Plur	_	_	_	_
12	of	of	ADP	IN	_	_	_	_	_
13	1,25	1,25	NUM	CD	NumType=Card	_	_	_	_
14	dihydroxyvitamin	dihydroxyvitamin	NOUN	NN	Number=Sing	_	_	_	_
15	D3	D3	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
16	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 947
# text = The biological active form of vitamin D3, 1,25-dihydroxyvitamin D3 (VD), regulates cellular growth and differentiation.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	biological	biological	ADJ	JJ	Degree=Pos	_	_	_	_
3	active	active	ADJ	JJ	Degree=Pos	_	_	_	_
4	form	form	NOUN	NN	Number=Sing	_	_	_	_
5	of	of	ADP	IN	_	_	_	_	_
6	vitamin	vitamin	ADJ	JJ	Degree=Pos	_	_	_	_
7	D3	D3	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
8	,	,	PUNCT	,	_	_	_	_	_
9	1,25	1,25	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
10	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
11	dihydroxyvitamin	dihydroxyvitamin	NOUN	NN	Number=Sing	_	_	_	_
12	D3	D3	NOUN	NN	Number=Sing	_	_	_	_
13	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
14	VD	VD	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
15	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
16	,	,	PUNCT	,	_	_	_	_	_
17	regulates	regulate	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
18	cellular	cellular	ADJ	JJ	Degree=Pos	_	_	_	_
19	growth	growth	NOUN	NN	Number=Sing	_	_	_	_
20	and	and	CCONJ	CC	_	_	_	_	_
21	differentiation	differentiation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
22	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 948
# text = This provides the hormone with an interesting therapeutic potential.
1	This	this	PRON	DT	Number=Sing|PronType=Dem	_	_	_	_
2	provides	provide	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
3	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
4	hormone	hormone	NOUN	NN	Number=Sing	_	_	_	_
5	with	with	ADP	IN	_	_	_	_	_
6	an	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
7	interesting	interesting	ADJ	JJ	Degree=Pos	_	_	_	_
8	therapeutic	therapeutic	ADJ	JJ	Degree=Pos	_	_	_	_
9	potential	potential	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
10	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 949
# text = However, hypercalcemia is a side effect, which is caused by VD's classical action, the regulation of calcium homeostasis.
1	However	however	ADV	RB	_	_	_	_	SpaceAfter=No
2	,	,	PUNCT	,	_	_	_	_	_
3	hypercalcemia	hypercalcemia	NOUN	NN	Number=Sing	_	_	_	_
4	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
5	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
6	side	side	NOUN	NN	Number=Sing	_	_	_	_
7	effect	effect	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
8	,	,	PUNCT	,	_	_	_	_	_
9	which	which	PRON	WDT	PronType=Rel	_	_	_	_
10	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
11	caused	cause	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
12	by	by	ADP	IN	_	_	_	_	_
13	VD	VD	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
14	's	's	PART	POS	_	_	_	_	_
15	classical	classical	ADJ	JJ	Degree=Pos	_	_	_	_
16	action	action	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
17	,	,	PUNCT	,	_	_	_	_	_
18	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
19	regulation	regulation	NOUN	NN	Number=Sing	_	_	_	_
20	of	of	ADP	IN	_	_	_	_	_
21	calcium	calcium	NOUN	NN	Number=Sing	_	_	_	_
22	homeostasis	homeostasis	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
23	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 950
# text = This made the need for VD analogues with selectively increased cell regulatory properties.
1	This	this	PRON	DT	Number=Sing|PronType=Dem	_	_	_	_
2	made	make	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
3	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
4	need	need	NOUN	NN	Number=Sing	_	_	_	_
5	for	for	ADP	IN	_	_	_	_	_
6	VD	Vd	ADJ	JJ	Degree=Pos	_	_	_	_
7	analogues	analogue	NOUN	NNS	Number=Plur	_	_	_	_
8	with	with	ADP	IN	_	_	_	_	_
9	selectively	selectively	ADV	RB	_	_	_	_	_
10	increased	increase	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
11	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
12	regulatory	regulatory	ADJ	JJ	Degree=Pos	_	_	_	_
13	properties	property	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
14	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 951
# text = Studies with 20-epi analogues pointed out the importance of the carbon-20 position and led to the development of 20-methyl derivatives of VD.
1	Studies	study	NOUN	NNS	Number=Plur	_	_	_	_
2	with	with	ADP	IN	_	_	_	_	_
3	20	20	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
4	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
5	epi	epi	NOUN	NN	Number=Sing	_	_	_	_
6	analogues	analogue	NOUN	NNS	Number=Plur	_	_	_	_
7	pointed	point	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
8	out	out	ADP	RP	_	_	_	_	_
9	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
10	importance	importance	NOUN	NN	Number=Sing	_	_	_	_
11	of	of	ADP	IN	_	_	_	_	_
12	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
13	carbon	carbon	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
14	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
15	20	20	NUM	CD	NumType=Card	_	_	_	_
16	position	position	NOUN	NN	Number=Sing	_	_	_	_
17	and	and	CCONJ	CC	_	_	_	_	_
18	led	lead	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
19	to	to	ADP	IN	_	_	_	_	_
20	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
21	development	development	NOUN	NN	Number=Sing	_	_	_	_
22	of	of	ADP	IN	_	_	_	_	_
23	20	20	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
24	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
25	methyl	methyl	NOUN	NN	Number=Sing	_	_	_	_
26	derivatives	derivative	NOUN	NNS	Number=Plur	_	_	_	_
27	of	of	ADP	IN	_	_	_	_	_
28	VD	VD	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
29	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 952
# text = In this report the biological properties of the compounds ZK161422 and ZK157202, which are 20-methyl- and 20-methyl-23-eneanalogues, respectively, have been analyzed in comparison with VD.
1	In	in	ADP	IN	_	_	_	_	_
2	this	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
3	report	report	NOUN	NN	Number=Sing	_	_	_	_
4	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
5	biological	biological	ADJ	JJ	Degree=Pos	_	_	_	_
6	properties	property	NOUN	NNS	Number=Plur	_	_	_	_
7	of	of	ADP	IN	_	_	_	_	_
8	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
9	compounds	compound	NOUN	NNS	Number=Plur	_	_	_	_
10	ZK161422	Zk161422	NUM	CD	NumType=Card	_	_	_	_
11	and	and	CCONJ	CC	_	_	_	_	_
12	ZK157202	Zk157202	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
13	,	,	PUNCT	,	_	_	_	_	_
14	which	which	PRON	WDT	PronType=Rel	_	_	_	_
15	are	be	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
16	20	20	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
17	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
18	methyl	methyl	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
19	-	-	PUNCT	HYPH	_	_	_	_	_
20	and	and	CCONJ	CC	_	_	_	_	_
21	20-methyl	20-methyl	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
22	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
23	23	23	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
24	-eneanalogues	-eneanalogue	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
25	,	,	PUNCT	,	_	_	_	_	_
26	respectively	respectively	ADV	RB	_	_	_	_	SpaceAfter=No
27	,	,	PUNCT	,	_	_	_	_	_
28	have	have	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
29	been	be	AUX	VBN	Tense=Past|VerbForm=Part	_	_	_	_
30	analyzed	analyze	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
31	in	in	ADP	IN	_	_	_	_	_
32	comparison	comparison	NOUN	NN	Number=Sing	_	_	_	_
33	with	with	ADP	IN	_	_	_	_	_
34	VD	VD	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
35	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 953
# text = Both compounds show about 2-fold lower affinity to the VD receptor (VDR) than VD.
1	Both	both	DET	DT	_	_	_	_	_
2	compounds	compound	NOUN	NNS	Number=Plur	_	_	_	_
3	show	show	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
4	about	about	ADP	IN	_	_	_	_	_
5	2	2	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
6	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
7	fold	fold	VERB	VB	VerbForm=Inf	_	_	_	_
8	lower	lower	ADJ	JJR	Degree=Cmp	_	_	_	_
9	affinity	affinity	NOUN	NN	Number=Sing	_	_	_	_
10	to	to	ADP	IN	_	_	_	_	_
11	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
12	VD	V	PROPN	NNP	Number=Sing	_	_	_	_
13	receptor	receptor	NOUN	NN	Number=Sing	_	_	_	_
14	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
15	VDR	VDR	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
16	)	)	PUNCT	-RRB-	_	_	_	_	_
17	than	than	ADP	IN	_	_	_	_	_
18	VD	VD	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
19	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 954
# text = However, compared to VD, their antiproliferative effect is up to 30-fold higher on human peripheral blood mononuclear cells and even up to 300-fold higher on human breast cancer MCF-7 cells.
1	However	however	ADV	RB	_	_	_	_	SpaceAfter=No
2	,	,	PUNCT	,	_	_	_	_	_
3	compared	compare	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
4	to	to	ADP	IN	_	_	_	_	_
5	VD	VD	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
6	,	,	PUNCT	,	_	_	_	_	_
7	their	they	PRON	PRP$	Number=Plur|Person=3|Poss=Yes|PronType=Prs	_	_	_	_
8	antiproliferative	antiproliferative	ADJ	JJ	Degree=Pos	_	_	_	_
9	effect	effect	NOUN	NN	Number=Sing	_	_	_	_
10	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
11	up	up	ADV	RB	_	_	_	_	_
12	to	to	ADP	IN	_	_	_	_	_
13	30	30	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
14	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
15	fold	fold	NOUN	NN	Number=Sing	_	_	_	_
16	higher	higher	ADV	RBR	Degree=Cmp	_	_	_	_
17	on	on	ADP	IN	_	_	_	_	_
18	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
19	peripheral	peripheral	ADJ	JJ	Degree=Pos	_	_	_	_
20	blood	blood	NOUN	NN	Number=Sing	_	_	_	_
21	mononuclear	mononuclear	ADJ	JJ	Degree=Pos	_	_	_	_
22	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
23	and	and	CCONJ	CC	_	_	_	_	_
24	even	even	ADV	RB	_	_	_	_	_
25	up	up	ADP	IN	_	_	_	_	_
26	to	to	ADP	IN	_	_	_	_	_
27	300	300	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
28	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
29	fold	fold	NOUN	NN	Number=Sing	_	_	_	_
30	higher	higher	ADV	RBR	Degree=Cmp	_	_	_	_
31	on	on	ADP	IN	_	_	_	_	_
32	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
33	breast	breast	NOUN	NN	Number=Sing	_	_	_	_
34	cancer	cancer	NOUN	NN	Number=Sing	_	_	_	_
35	MCF	Mcf	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
36	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
37	7	7	NUM	CD	NumType=Card	_	_	_	_
38	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
39	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 955
# text = Whereas the hypercalcemic effect for ZK157202 is also increased 10-fold, ZK161422 has the same calcium-mobilizing potency as VD.
1	Whereas	whereas	SCONJ	IN	_	_	_	_	_
2	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
3	hypercalcemic	hypercalcemic	ADJ	JJ	Degree=Pos	_	_	_	_
4	effect	effect	NOUN	NN	Number=Sing	_	_	_	_
5	for	for	ADP	IN	_	_	_	_	_
6	ZK157202	ZK157202	NOUN	NN	Number=Sing	_	_	_	_
7	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
8	also	also	ADV	RB	_	_	_	_	_
9	increased	increase	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
10	10	10	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
11	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
12	fold	fold	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
13	,	,	PUNCT	,	_	_	_	_	_
14	ZK	ZK	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
15	161422	161422	NUM	CD	NumType=Card	_	_	_	_
16	has	have	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
17	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
18	same	same	ADJ	JJ	Degree=Pos	_	_	_	_
19	calcium	calcium	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
20	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
21	mobilizing	mobilizing	NOUN	NN	Number=Sing	_	_	_	_
22	potency	potency	NOUN	NN	Number=Sing	_	_	_	_
23	as	as	ADP	IN	_	_	_	_	_
24	VD	VD	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
25	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 956
# text = Moreover, ZK161422, but not ZK157202, showed preference for gene activation from a promoter carrying a VD response element with a palindromic arrangement of two hexameric receptor binding sites spaced by 9 nucleotides (IP9) rather than for activation from a response element formed by a direct repeat spaced by 3 nucleotides (DR3).
1	Moreover	moreover	ADV	RB	_	_	_	_	SpaceAfter=No
2	,	,	PUNCT	,	_	_	_	_	_
3	ZK	ZK	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
4	161422	161422	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
5	,	,	PUNCT	,	_	_	_	_	_
6	but	but	CCONJ	CC	_	_	_	_	_
7	not	not	ADV	RB	_	_	_	_	_
8	ZK157202	ZK157202	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
9	,	,	PUNCT	,	_	_	_	_	_
10	showed	show	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
11	preference	preference	NOUN	NN	Number=Sing	_	_	_	_
12	for	for	ADP	IN	_	_	_	_	_
13	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
14	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
15	from	from	ADP	IN	_	_	_	_	_
16	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
17	promoter	promoter	NOUN	NN	Number=Sing	_	_	_	_
18	carrying	carry	VERB	VBG	VerbForm=Ger	_	_	_	_
19	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
20	VD	Vd	PROPN	NNP	Number=Sing	_	_	_	_
21	response	response	NOUN	NN	Number=Sing	_	_	_	_
22	element	element	NOUN	NN	Number=Sing	_	_	_	_
23	with	with	ADP	IN	_	_	_	_	_
24	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
25	palindromic	palindromic	ADJ	JJ	Degree=Pos	_	_	_	_
26	arrangement	arrangement	NOUN	NN	Number=Sing	_	_	_	_
27	of	of	ADP	IN	_	_	_	_	_
28	two	two	NUM	CD	NumType=Card	_	_	_	_
29	hexameric	hexameric	ADJ	JJ	Degree=Pos	_	_	_	_
30	receptor	receptor	NOUN	NN	Number=Sing	_	_	_	_
31	binding	bind	VERB	VBG	VerbForm=Ger	_	_	_	_
32	sites	site	NOUN	NNS	Number=Plur	_	_	_	_
33	spaced	space	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
34	by	by	ADP	IN	_	_	_	_	_
35	9	9	NUM	CD	NumType=Card	_	_	_	_
36	nucleotides	nucleotide	NOUN	NNS	Number=Plur	_	_	_	_
37	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
38	IP9	IP9	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
39	)	)	PUNCT	-RRB-	_	_	_	_	_
40	rather	rather	ADV	RB	_	_	_	_	_
41	than	than	ADP	IN	_	_	_	_	_
42	for	for	ADP	IN	_	_	_	_	_
43	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
44	from	from	ADP	IN	_	_	_	_	_
45	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
46	response	response	NOUN	NN	Number=Sing	_	_	_	_
47	element	element	NOUN	NN	Number=Sing	_	_	_	_
48	formed	form	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
49	by	by	ADP	IN	_	_	_	_	_
50	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
51	direct	direct	ADJ	JJ	Degree=Pos	_	_	_	_
52	repeat	repeat	NOUN	NN	Number=Sing	_	_	_	_
53	spaced	space	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
54	by	by	ADP	IN	_	_	_	_	_
55	3	3	NUM	CD	NumType=Card	_	_	_	_
56	nucleotides	nucleotide	NOUN	NNS	Number=Plur	_	_	_	_
57	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
58	DR3	DR3	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
59	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
60	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 957
# text = This observation supports a model, in which promoter selectivity reflects the selectively increased antiproliferative effect of VD analogues.
1	This	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
2	observation	observation	NOUN	NN	Number=Sing	_	_	_	_
3	supports	support	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
4	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
5	model	model	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
6	,	,	PUNCT	,	_	_	_	_	_
7	in	in	ADP	IN	_	_	_	_	_
8	which	which	PRON	WDT	PronType=Rel	_	_	_	_
9	promoter	promoter	ADJ	JJR	Degree=Cmp	_	_	_	_
10	selectivity	selectivity	NOUN	NN	Number=Sing	_	_	_	_
11	reflects	reflect	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
12	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
13	selectively	selectively	ADV	RB	_	_	_	_	_
14	increased	increase	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
15	antiproliferative	antiproliferative	ADJ	JJ	Degree=Pos	_	_	_	_
16	effect	effect	NOUN	NN	Number=Sing	_	_	_	_
17	of	of	ADP	IN	_	_	_	_	_
18	VD	Vd	ADJ	JJ	Degree=Pos	_	_	_	_
19	analogues	analogue	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
20	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 958
# text = Document 003002355 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	003002355	003002355	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 959
# text = Cell-specific bifunctional role of Jun oncogene family members on glucocorticoid receptor-dependent transcription.
1	Cell	cell	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
2	-	-	PUNCT	:	_	_	_	_	SpaceAfter=No
3	specific	specific	ADJ	JJ	Degree=Pos	_	_	_	_
4	bifunctional	bifunctional	ADJ	JJ	Degree=Pos	_	_	_	_
5	role	role	NOUN	NN	Number=Sing	_	_	_	_
6	of	of	ADP	IN	_	_	_	_	_
7	Jun	Jun	PROPN	NNP	Number=Sing	_	_	_	_
8	oncogene	oncogene	ADJ	JJ	Degree=Pos	_	_	_	_
9	family	family	NOUN	NN	Number=Sing	_	_	_	_
10	members	member	NOUN	NNS	Number=Plur	_	_	_	_
11	on	on	ADP	IN	_	_	_	_	_
12	glucocorticoid	glucocorticoid	ADJ	JJ	Degree=Pos	_	_	_	_
13	receptor	receptor	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
14	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
15	dependent	dependent	ADJ	JJ	Degree=Pos	_	_	_	_
16	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
17	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 960
# text = Interaction between protein kinase C (PKC)- and glucocorticoid receptor (GR)-mediated signaling is suggested by the ability of the PKC activating phorbol ester 12-O-tetradecanoylphorbol-13-acetate (TPA) to inhibit GR-dependent transcription of the mouse mammary tumor virus (MMTV) long terminal repeat (LTR).
1	Interaction	interaction	NOUN	NN	Number=Sing	_	_	_	_
2	between	between	ADP	IN	_	_	_	_	_
3	protein	protein	NOUN	NN	Number=Sing	_	_	_	_
4	kinase	kinase	NOUN	NN	Number=Sing	_	_	_	_
5	C	C	PROPN	NNP	Number=Sing	_	_	_	_
6	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
7	PKC	PKC	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
8	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
9	-	-	PUNCT	:	_	_	_	_	_
10	and	and	CCONJ	CC	_	_	_	_	_
11	glucocorticoid	glucocorticoid	ADJ	JJ	Degree=Pos	_	_	_	_
12	receptor	receptor	NOUN	NN	Number=Sing	_	_	_	_
13	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
14	GR	GR	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
15	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
16	-	-	PUNCT	:	_	_	_	_	SpaceAfter=No
17	mediated	mediate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
18	signaling	signaling	NOUN	NN	Number=Sing	_	_	_	_
19	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
20	suggested	suggest	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
21	by	by	ADP	IN	_	_	_	_	_
22	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
23	ability	ability	NOUN	NN	Number=Sing	_	_	_	_
24	of	of	ADP	IN	_	_	_	_	_
25	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
26	PKC	Pkc	NOUN	NN	Number=Sing	_	_	_	_
27	activating	activat	VERB	VBG	VerbForm=Ger	_	_	_	_
28	phorbol	phorbol	NOUN	NN	Number=Sing	_	_	_	_
29	ester	ester	NOUN	NN	Number=Sing	_	_	_	_
30	12-O-tetradecanoylphorbol	12-O-tetradecanoylphorbol	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
31	-13	-13	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
32	-acetate	-acetate	NOUN	NN	Number=Sing	_	_	_	_
33	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
34	TPA	TPA	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
35	)	)	PUNCT	-RRB-	_	_	_	_	_
36	to	to	PART	TO	_	_	_	_	_
37	inhibit	inhibit	VERB	VB	VerbForm=Inf	_	_	_	_
38	GR	Gr	ADV	RB	_	_	_	_	SpaceAfter=No
39	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
40	dependent	dependent	ADJ	JJ	Degree=Pos	_	_	_	_
41	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
42	of	of	ADP	IN	_	_	_	_	_
43	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
44	mouse	mouse	NOUN	NN	Number=Sing	_	_	_	_
45	mammary	mammary	NOUN	NN	Number=Sing	_	_	_	_
46	tumor	tumor	NOUN	NN	Number=Sing	_	_	_	_
47	virus	virus	NOUN	NN	Number=Sing	_	_	_	_
48	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
49	MMTV	MMTV	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
50	)	)	PUNCT	-RRB-	_	_	_	_	_
51	long	long	ADJ	JJ	Degree=Pos	_	_	_	_
52	terminal	terminal	NOUN	NN	Number=Sing	_	_	_	_
53	repeat	repeat	NOUN	NN	Number=Sing	_	_	_	_
54	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
55	LTR	LTR	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
56	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
57	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 961
# text = Here we report that this interference is cell specific, as TPA augmented dexamethasone-induced transcriptional activation of the MMTV LTR in several T cell lines but was inhibitory in NIH-3T3 fibroblasts.
1	Here	here	ADV	RB	PronType=Dem	_	_	_	_
2	we	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
3	report	report	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
4	that	that	SCONJ	IN	_	_	_	_	_
5	this	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
6	interference	interference	NOUN	NN	Number=Sing	_	_	_	_
7	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
8	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
9	specific	specific	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
10	,	,	PUNCT	,	_	_	_	_	_
11	as	as	SCONJ	IN	_	_	_	_	_
12	TPA	TPA	PROPN	NNP	Number=Sing	_	_	_	_
13	augmented	augment	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
14	dexamethasone	dexamethasone	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
15	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
16	induced	induce	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
17	transcriptional	transcriptional	ADJ	JJ	Degree=Pos	_	_	_	_
18	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
19	of	of	ADP	IN	_	_	_	_	_
20	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
21	MMTV	MMTV	PROPN	NNP	Number=Sing	_	_	_	_
22	LTR	LTR	PROPN	NNP	Number=Sing	_	_	_	_
23	in	in	ADP	IN	_	_	_	_	_
24	several	several	ADJ	JJ	Degree=Pos	_	_	_	_
25	T	T	PROPN	NNP	Number=Sing	_	_	_	_
26	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
27	lines	line	NOUN	NNS	Number=Plur	_	_	_	_
28	but	but	CCONJ	CC	_	_	_	_	_
29	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
30	inhibitory	inhibitory	ADJ	JJ	Degree=Pos	_	_	_	_
31	in	in	ADP	IN	_	_	_	_	_
32	NIH	NIH	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
33	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
34	3T3	3T3	NUM	CD	NumType=Card	_	_	_	_
35	fibroblasts	fibroblast	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
36	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 962
# text = TPA-GR synergism was determined to have occurred at the GR-responsive element (GRE) level by functional analysis of deletion mutants or synthetic GRE oligonucleotides driving chloramphenicol acetyl-transferase expression.
1	TPA	TPa	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
2	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
3	GR	Gr	NOUN	NN	Number=Sing	_	_	_	_
4	synergism	synergism	NOUN	NN	Number=Sing	_	_	_	_
5	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
6	determined	determined	ADJ	JJ	Degree=Pos	_	_	_	_
7	to	to	PART	TO	_	_	_	_	_
8	have	have	AUX	VB	VerbForm=Inf	_	_	_	_
9	occurred	occur	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
10	at	at	ADP	IN	_	_	_	_	_
11	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
12	GR	GR	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
13	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
14	responsive	responsive	ADJ	JJ	Degree=Pos	_	_	_	_
15	element	element	NOUN	NN	Number=Sing	_	_	_	_
16	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
17	GRE	GRE	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
18	)	)	PUNCT	-RRB-	_	_	_	_	_
19	level	level	NOUN	NN	Number=Sing	_	_	_	_
20	by	by	ADP	IN	_	_	_	_	_
21	functional	functional	ADJ	JJ	Degree=Pos	_	_	_	_
22	analysis	analysis	NOUN	NN	Number=Sing	_	_	_	_
23	of	of	ADP	IN	_	_	_	_	_
24	deletion	deletion	NOUN	NN	Number=Sing	_	_	_	_
25	mutants	mutant	NOUN	NNS	Number=Plur	_	_	_	_
26	or	or	CCONJ	CC	_	_	_	_	_
27	synthetic	synthetic	ADJ	JJ	Degree=Pos	_	_	_	_
28	GRE	Gre	NOUN	NN	Number=Sing	_	_	_	_
29	oligonucleotides	oligonucleotide	SCONJ	IN	_	_	_	_	_
30	driving	drive	VERB	VBG	VerbForm=Ger	_	_	_	_
31	chloramphenicol	chloramphenicol	NOUN	NN	Number=Sing	_	_	_	_
32	acetyl	acetyl	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
33	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
34	transferase	transferase	NOUN	NN	Number=Sing	_	_	_	_
35	expression	expression	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
36	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 963
# text = Synergism required an intact GR DNA-binding domain, whereas amino- or carboxyl-terminal domains were dispensable.
1	Synergism	Synergism	PROPN	NNP	Number=Sing	_	_	_	_
2	required	require	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
3	an	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
4	intact	intact	ADJ	JJ	Degree=Pos	_	_	_	_
5	GR	Gr	NOUN	NN	Number=Sing	_	_	_	_
6	DNA	dna	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
7	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
8	binding	bind	VERB	VBG	VerbForm=Ger	_	_	_	_
9	domain	domain	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
10	,	,	PUNCT	,	_	_	_	_	_
11	whereas	whereas	SCONJ	IN	_	_	_	_	_
12	amino	amino	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
13	-	-	PUNCT	HYPH	_	_	_	_	_
14	or	or	CCONJ	CC	_	_	_	_	_
15	carboxyl	carboxyl	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
16	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
17	terminal	terminal	ADJ	JJ	Degree=Pos	_	_	_	_
18	domains	domain	NOUN	NNS	Number=Plur	_	_	_	_
19	were	be	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
20	dispensable	dispensable	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
21	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 964
# text = The effect was abrogated by the PKC inhibitor staurosporine, suggesting a role for PKC.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	effect	effect	NOUN	NN	Number=Sing	_	_	_	_
3	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
4	abrogated	abrogate	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
5	by	by	ADP	IN	_	_	_	_	_
6	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
7	PKC	PKC	NOUN	NN	Number=Sing	_	_	_	_
8	inhibitor	inhibitor	NOUN	NN	Number=Sing	_	_	_	_
9	staurosporine	staurosporine	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
10	,	,	PUNCT	,	_	_	_	_	_
11	suggesting	suggest	VERB	VBG	VerbForm=Ger	_	_	_	_
12	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
13	role	role	NOUN	NN	Number=Sing	_	_	_	_
14	for	for	ADP	IN	_	_	_	_	_
15	PKC	PKC	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
16	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 965
# text = Increased c-jun, jun-B, and jun-D expression above basal levels and increased transcriptional activity of AP-1/TPA responsive elements fused to chloramphenicol acetyl-transferase vectors were observed in T cells treated with TPA alone or in combination with dexamethasone.
1	Increased	increase	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
2	c-	c-	SYM	NFP	_	_	_	_	SpaceAfter=No
3	jun	jun	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
4	,	,	PUNCT	,	_	_	_	_	_
5	jun	jun	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
6	-B	-b	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
7	,	,	PUNCT	,	_	_	_	_	_
8	and	and	CCONJ	CC	_	_	_	_	_
9	jun	jun	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
10	-D	-d	ADJ	JJ	Degree=Pos	_	_	_	_
11	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
12	above	above	ADP	IN	_	_	_	_	_
13	basal	basal	ADJ	JJ	Degree=Pos	_	_	_	_
14	levels	level	NOUN	NNS	Number=Plur	_	_	_	_
15	and	and	CCONJ	CC	_	_	_	_	_
16	increased	increase	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
17	transcriptional	transcriptional	ADJ	JJ	Degree=Pos	_	_	_	_
18	activity	activity	NOUN	NN	Number=Sing	_	_	_	_
19	of	of	ADP	IN	_	_	_	_	_
20	AP	Ap	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
21	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
22	1	1	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
23	/	/	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
24	TPA	TPa	NOUN	NN	Number=Sing	_	_	_	_
25	responsive	responsive	ADJ	JJ	Degree=Pos	_	_	_	_
26	elements	element	NOUN	NNS	Number=Plur	_	_	_	_
27	fused	fuse	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
28	to	to	PART	TO	_	_	_	_	_
29	chloramphenicol	chloramphenicol	VERB	VB	VerbForm=Inf	_	_	_	_
30	acetyl	acetyl	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
31	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
32	transferase	transferase	NOUN	NN	Number=Sing	_	_	_	_
33	vectors	vector	NOUN	NNS	Number=Plur	_	_	_	_
34	were	be	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
35	observed	observe	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
36	in	in	ADP	IN	_	_	_	_	_
37	T	t	PROPN	NNP	Number=Sing	_	_	_	_
38	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
39	treated	treat	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
40	with	with	ADP	IN	_	_	_	_	_
41	TPA	TPA	PROPN	NNP	Number=Sing	_	_	_	_
42	alone	alone	ADV	RB	_	_	_	_	_
43	or	or	CCONJ	CC	_	_	_	_	_
44	in	in	ADP	IN	_	_	_	_	_
45	combination	combination	NOUN	NN	Number=Sing	_	_	_	_
46	with	with	ADP	IN	_	_	_	_	_
47	dexamethasone	dexamethasone	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
48	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 966
# text = The ability of Jun proteins to cooperate with GR in T cells has been investigated after transfection of c-jun, jun-B, or jun-D expression vectors, which augmented GR-dependent transcription from either MMTV LTR or GRE.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	ability	ability	NOUN	NN	Number=Sing	_	_	_	_
3	of	of	ADP	IN	_	_	_	_	_
4	Jun	Jun	PROPN	NNP	Number=Sing	_	_	_	_
5	proteins	protein	NOUN	NNS	Number=Plur	_	_	_	_
6	to	to	PART	TO	_	_	_	_	_
7	cooperate	cooperate	VERB	VB	VerbForm=Inf	_	_	_	_
8	with	with	ADP	IN	_	_	_	_	_
9	GR	GR	PROPN	NNP	Number=Sing	_	_	_	_
10	in	in	ADP	IN	_	_	_	_	_
11	T	T	PROPN	NNP	Number=Sing	_	_	_	_
12	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
13	has	have	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
14	been	be	AUX	VBN	Tense=Past|VerbForm=Part	_	_	_	_
15	investigated	investigate	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
16	after	after	ADP	IN	_	_	_	_	_
17	transfection	transfection	NOUN	NN	Number=Sing	_	_	_	_
18	of	of	ADP	IN	_	_	_	_	_
19	c-	c-	SYM	NFP	_	_	_	_	SpaceAfter=No
20	jun	jun	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
21	,	,	PUNCT	,	_	_	_	_	_
22	jun	jun	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
23	-B	-b	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
24	,	,	PUNCT	,	_	_	_	_	_
25	or	or	CCONJ	CC	_	_	_	_	_
26	jun	jun	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
27	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
28	D	d	NOUN	NN	Number=Sing	_	_	_	_
29	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
30	vectors	vector	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
31	,	,	PUNCT	,	_	_	_	_	_
32	which	which	PRON	WDT	PronType=Rel	_	_	_	_
33	augmented	augment	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
34	GR	GR	ADV	RB	_	_	_	_	SpaceAfter=No
35	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
36	dependent	dependent	ADJ	JJ	Degree=Pos	_	_	_	_
37	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
38	from	from	ADP	IN	_	_	_	_	_
39	either	either	CCONJ	CC	_	_	_	_	_
40	MMTV	MMTV	PROPN	NNP	Number=Sing	_	_	_	_
41	LTR	LTR	PROPN	NNP	Number=Sing	_	_	_	_
42	or	or	CCONJ	CC	_	_	_	_	_
43	GRE	GRE	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
44	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 967
# text = Conversely, c-jun and jun-B transfection blunted GR-dependent transcription in HeLa cells.
1	Conversely	Conversely	ADV	RB	_	_	_	_	SpaceAfter=No
2	,	,	PUNCT	,	_	_	_	_	_
3	c-	c-	SYM	NFP	_	_	_	_	SpaceAfter=No
4	jun	jun	ADJ	JJ	Degree=Pos	_	_	_	_
5	and	and	CCONJ	CC	_	_	_	_	_
6	jun	jun	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
7	-B	-b	ADJ	JJ	Degree=Pos	_	_	_	_
8	transfection	transfection	NOUN	NN	Number=Sing	_	_	_	_
9	blunted	blunt	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
10	GR	GR	ADV	RB	_	_	_	_	SpaceAfter=No
11	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
12	dependent	dependent	ADJ	JJ	Degree=Pos	_	_	_	_
13	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
14	in	in	ADP	IN	_	_	_	_	_
15	HeLa	HeLa	PROPN	NNP	Number=Sing	_	_	_	_
16	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
17	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 968
# text = The presence of c-fos had a negative influence on GR function and correlated with the cell-specific synergistic or antagonistic activity of Jun with respect to GR; high basal expression of c-fos as well as AP-1 DNA binding and transcriptional activity were observed in HeLa cells, but not in T cells.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	presence	presence	NOUN	NN	Number=Sing	_	_	_	_
3	of	of	ADP	IN	_	_	_	_	_
4	c	c	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
5	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
6	fos	fo	NOUN	NNS	Number=Plur	_	_	_	_
7	had	have	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
8	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
9	negative	negative	ADJ	JJ	Degree=Pos	_	_	_	_
10	influence	influence	NOUN	NN	Number=Sing	_	_	_	_
11	on	on	ADP	IN	_	_	_	_	_
12	GR	Gr	NOUN	NN	Number=Sing	_	_	_	_
13	function	function	NOUN	NN	Number=Sing	_	_	_	_
14	and	and	CCONJ	CC	_	_	_	_	_
15	correlated	correlate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
16	with	with	ADP	IN	_	_	_	_	_
17	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
18	cell	cell	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
19	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
20	specific	specific	ADJ	JJ	Degree=Pos	_	_	_	_
21	synergistic	synergistic	ADJ	JJ	Degree=Pos	_	_	_	_
22	or	or	CCONJ	CC	_	_	_	_	_
23	antagonistic	antagonistic	ADJ	JJ	Degree=Pos	_	_	_	_
24	activity	activity	NOUN	NN	Number=Sing	_	_	_	_
25	of	of	ADP	IN	_	_	_	_	_
26	Jun	Jun	PROPN	NNP	Number=Sing	_	_	_	_
27	with	with	ADP	IN	_	_	_	_	_
28	respect	respect	NOUN	NN	Number=Sing	_	_	_	_
29	to	to	ADP	IN	_	_	_	_	_
30	GR	GR	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
31	;	;	PUNCT	,	_	_	_	_	_
32	high	high	ADJ	JJ	Degree=Pos	_	_	_	_
33	basal	basal	NOUN	NN	Number=Sing	_	_	_	_
34	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
35	of	of	ADP	IN	_	_	_	_	_
36	c	c	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
37	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
38	fos	fo	NOUN	NNS	Number=Plur	_	_	_	_
39	as	as	ADV	RB	_	_	_	_	_
40	well	well	ADV	RB	Degree=Pos	_	_	_	_
41	as	as	ADP	IN	_	_	_	_	_
42	AP	Ap	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
43	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
44	1	1	NUM	CD	NumType=Card	_	_	_	_
45	DNA	dna	NOUN	NN	Number=Sing	_	_	_	_
46	binding	binding	VERB	VBG	VerbForm=Ger	_	_	_	_
47	and	and	CCONJ	CC	_	_	_	_	_
48	transcriptional	transcriptional	ADJ	JJ	Degree=Pos	_	_	_	_
49	activity	activity	NOUN	NN	Number=Sing	_	_	_	_
50	were	be	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
51	observed	observe	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
52	in	in	ADP	IN	_	_	_	_	_
53	HeLa	Hela	PROPN	NNP	Number=Sing	_	_	_	_
54	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
55	,	,	PUNCT	,	_	_	_	_	_
56	but	but	CCONJ	CC	_	_	_	_	_
57	not	not	ADV	RB	_	_	_	_	_
58	in	in	ADP	IN	_	_	_	_	_
59	T	t	PROPN	NNP	Number=Sing	_	_	_	_
60	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
61	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 969
# text = Furthermore overexpression of exogenous c-fos has an inhibitory effect on GR-dependent transcription from GRE in T cells.
1	Furthermore	furthermore	ADJ	JJ	Degree=Pos	_	_	_	_
2	overexpression	overexpression	NOUN	NN	Number=Sing	_	_	_	_
3	of	of	ADP	IN	_	_	_	_	_
4	exogenous	exogenous	ADJ	JJ	Degree=Pos	_	_	_	_
5	c	c	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
6	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
7	fos	fos	NOUN	NN	Number=Sing	_	_	_	_
8	has	have	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
9	an	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
10	inhibitory	inhibitory	ADJ	JJ	Degree=Pos	_	_	_	_
11	effect	effect	NOUN	NN	Number=Sing	_	_	_	_
12	on	on	ADP	IN	_	_	_	_	_
13	GR	Gr	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
14	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
15	dependent	dependent	ADJ	JJ	Degree=Pos	_	_	_	_
16	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
17	from	from	ADP	IN	_	_	_	_	_
18	GRE	GRE	PROPN	NNP	Number=Sing	_	_	_	_
19	in	in	ADP	IN	_	_	_	_	_
20	T	t	PROPN	NNP	Number=Sing	_	_	_	_
21	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
22	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 970
# text = We propose that Jun plays a bifunctional role on GR-dependent transcriptional activation of GRE, selecting either synergistic or antagonistic activity depending on the cell-specific microenvironment.
1	We	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
2	propose	propose	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
3	that	that	SCONJ	IN	_	_	_	_	_
4	Jun	Jun	PROPN	NNP	Number=Sing	_	_	_	_
5	plays	play	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
6	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
7	bifunctional	bifunctional	ADJ	JJ	Degree=Pos	_	_	_	_
8	role	role	NOUN	NN	Number=Sing	_	_	_	_
9	on	on	ADP	IN	_	_	_	_	_
10	GR	GR	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
11	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
12	dependent	dependent	ADJ	JJ	Degree=Pos	_	_	_	_
13	transcriptional	transcriptional	ADJ	JJ	Degree=Pos	_	_	_	_
14	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
15	of	of	ADP	IN	_	_	_	_	_
16	GRE	GRE	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
17	,	,	PUNCT	,	_	_	_	_	_
18	selecting	selecte	VERB	VBG	VerbForm=Ger	_	_	_	_
19	either	either	CCONJ	CC	_	_	_	_	_
20	synergistic	synergistic	ADJ	JJ	Degree=Pos	_	_	_	_
21	or	or	CCONJ	CC	_	_	_	_	_
22	antagonistic	antagonistic	ADJ	JJ	Degree=Pos	_	_	_	_
23	activity	activity	NOUN	NN	Number=Sing	_	_	_	_
24	depending	depend	VERB	VBG	VerbForm=Ger	_	_	_	_
25	on	on	ADP	IN	_	_	_	_	_
26	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
27	cell	cell	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
28	-specific	-specific	ADJ	JJ	Degree=Pos	_	_	_	_
29	microenvironment	microenvironment	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
30	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 971
# text = In this regard, intracellular levels of c-fos appear to be influential.
1	In	in	ADP	IN	_	_	_	_	_
2	this	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
3	regard	regard	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
4	,	,	PUNCT	,	_	_	_	_	_
5	intracellular	intracelular	ADJ	JJ	Degree=Pos	_	_	_	_
6	levels	level	NOUN	NNS	Number=Plur	_	_	_	_
7	of	of	ADP	IN	_	_	_	_	_
8	c	c	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
9	-	-	PUNCT	:	_	_	_	_	SpaceAfter=No
10	fos	fo	NOUN	NNS	Number=Plur	_	_	_	_
11	appear	appear	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
12	to	to	PART	TO	_	_	_	_	_
13	be	be	AUX	VB	VerbForm=Inf	_	_	_	_
14	influential	influential	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
15	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 972
# text = Document 003002357 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	003002357	003002357	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 973
# text = Cupric ion blocks NF kappa B activation through inhibiting the signal-induced phosphorylation of I kappa B alpha.
1	Cupric	Cupric	ADJ	JJ	Degree=Pos	_	_	_	_
2	ion	ion	NOUN	NN	Number=Sing	_	_	_	_
3	blocks	block	NOUN	NNS	Number=Plur	_	_	_	_
4	NF	NF	PROPN	NNP	Number=Sing	_	_	_	_
5	kappa	kappa	PROPN	NNP	Number=Sing	_	_	_	_
6	B	B	PROPN	NNP	Number=Sing	_	_	_	_
7	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
8	through	through	SCONJ	IN	_	_	_	_	_
9	inhibiting	inhibit	VERB	VBG	VerbForm=Ger	_	_	_	_
10	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
11	signal	signal	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
12	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
13	induced	induce	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
14	phosphorylation	phosphorylation	NOUN	NN	Number=Sing	_	_	_	_
15	of	of	ADP	IN	_	_	_	_	_
16	I	I	PRON	PRP	Case=Nom|Number=Sing|Person=1|PronType=Prs	_	_	_	_
17	kappa	kappa	PROPN	NNP	Number=Sing	_	_	_	_
18	B	B	PROPN	NNP	Number=Sing	_	_	_	_
19	alpha	alpha	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
20	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 974
# text = A transcription factor NF kappa B, which regulates expression of various cellular genes involved in immune responses and viral genes including HIV, is sequestered in the cytoplasm as a complex with an inhibitory protein I kappa B.
1	A	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
2	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
3	factor	factor	NOUN	NN	Number=Sing	_	_	_	_
4	NF	NF	PROPN	NNP	Number=Sing	_	_	_	_
5	kappa	kappa	PROPN	NNP	Number=Sing	_	_	_	_
6	B	B	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
7	,	,	PUNCT	,	_	_	_	_	_
8	which	which	PRON	WDT	PronType=Rel	_	_	_	_
9	regulates	regulate	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
10	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
11	of	of	ADP	IN	_	_	_	_	_
12	various	various	ADJ	JJ	Degree=Pos	_	_	_	_
13	cellular	cellular	ADJ	JJ	Degree=Pos	_	_	_	_
14	genes	gene	NOUN	NNS	Number=Plur	_	_	_	_
15	involved	involved	ADJ	JJ	Degree=Pos	_	_	_	_
16	in	in	ADP	IN	_	_	_	_	_
17	immune	immune	ADJ	JJ	Degree=Pos	_	_	_	_
18	responses	respons	NOUN	NNS	Number=Plur	_	_	_	_
19	and	and	CCONJ	CC	_	_	_	_	_
20	viral	viral	ADJ	JJ	Degree=Pos	_	_	_	_
21	genes	gene	NOUN	NNS	Number=Plur	_	_	_	_
22	including	include	VERB	VBG	VerbForm=Ger	_	_	_	_
23	HIV	HIV	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
24	,	,	PUNCT	,	_	_	_	_	_
25	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
26	sequestered	sequester	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
27	in	in	ADP	IN	_	_	_	_	_
28	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
29	cytoplasm	cytoplasm	NOUN	NN	Number=Sing	_	_	_	_
30	as	as	ADP	IN	_	_	_	_	_
31	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
32	complex	complex	NOUN	NN	Number=Sing	_	_	_	_
33	with	with	ADP	IN	_	_	_	_	_
34	an	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
35	inhibitory	inhibitory	ADJ	JJ	Degree=Pos	_	_	_	_
36	protein	protein	NOUN	NN	Number=Sing	_	_	_	_
37	I	I	PRON	PRP	Case=Nom|Number=Sing|Person=1|PronType=Prs	_	_	_	_
38	kappa	kappa	PROPN	NNP	Number=Sing	_	_	_	_
39	B	B	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
40	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 975
# text = Various extracellular signals induce phosphorylation and rapid degradation of I kappa B alpha to release NF kappa B. Cu2+ was found to inhibit the activation of NF kappa B induced by TNF-alpha, TPA, or H2O2.
1	Various	various	ADJ	JJ	Degree=Pos	_	_	_	_
2	extracellular	extracellular	ADJ	JJ	Degree=Pos	_	_	_	_
3	signals	signal	NOUN	NNS	Number=Plur	_	_	_	_
4	induce	induce	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
5	phosphorylation	phosphorylation	NOUN	NN	Number=Sing	_	_	_	_
6	and	and	CCONJ	CC	_	_	_	_	_
7	rapid	rapid	ADJ	JJ	Degree=Pos	_	_	_	_
8	degradation	degradation	NOUN	NN	Number=Sing	_	_	_	_
9	of	of	ADP	IN	_	_	_	_	_
10	I	I	PRON	PRP	Case=Nom|Number=Sing|Person=1|PronType=Prs	_	_	_	_
11	kappa	kappa	X	FW	Foreign=Yes	_	_	_	_
12	B	b	ADJ	JJ	Degree=Pos	_	_	_	_
13	alpha	alpha	NOUN	NN	Number=Sing	_	_	_	_
14	to	to	PART	TO	_	_	_	_	_
15	release	release	VERB	VB	VerbForm=Inf	_	_	_	_
16	NF	NF	PROPN	NNP	Number=Sing	_	_	_	_
17	kappa	kappa	PROPN	NNP	Number=Sing	_	_	_	_
18	B.	B.	PROPN	NNP	Number=Sing	_	_	_	_
19	Cu2	cu2	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
20	+	+	SYM	SYM	_	_	_	_	_
21	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
22	found	find	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
23	to	to	PART	TO	_	_	_	_	_
24	inhibit	inhibit	VERB	VB	VerbForm=Inf	_	_	_	_
25	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
26	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
27	of	of	ADP	IN	_	_	_	_	_
28	NF	NF	PROPN	NNP	Number=Sing	_	_	_	_
29	kappa	kappa	PROPN	NNP	Number=Sing	_	_	_	_
30	B	b	PROPN	NNP	Number=Sing	_	_	_	_
31	induced	induce	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
32	by	by	ADP	IN	_	_	_	_	_
33	TNF	TNF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
34	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
35	alpha	alpha	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
36	,	,	PUNCT	,	_	_	_	_	_
37	TPA	Tpa	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
38	,	,	PUNCT	,	_	_	_	_	_
39	or	or	CCONJ	CC	_	_	_	_	_
40	H2	H2	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
41	O2	O2	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
42	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 976
# text = Deoxycholate treatment of the cytoplasmic extract prepared from cells stimulated by TNF-alpha in the presence of Cu2+ resulted in the release of NF kappa B from I kappa B alpha, indicating that Cu2+ interferes with the dissociation of the NF kappa B-I kappa B complex.
1	Deoxycholate	Deoxycholate	ADJ	JJ	Degree=Pos	_	_	_	_
2	treatment	treatment	NOUN	NN	Number=Sing	_	_	_	_
3	of	of	ADP	IN	_	_	_	_	_
4	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
5	cytoplasmic	cytoplasmic	ADJ	JJ	Degree=Pos	_	_	_	_
6	extract	extract	NOUN	NN	Number=Sing	_	_	_	_
7	prepared	prepare	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
8	from	from	ADP	IN	_	_	_	_	_
9	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
10	stimulated	stimulate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
11	by	by	ADP	IN	_	_	_	_	_
12	TNF	TNF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
13	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
14	alpha	alpha	NOUN	NN	Number=Sing	_	_	_	_
15	in	in	ADP	IN	_	_	_	_	_
16	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
17	presence	presence	NOUN	NN	Number=Sing	_	_	_	_
18	of	of	ADP	IN	_	_	_	_	_
19	Cu2	Cu2	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
20	+	+	SYM	SYM	_	_	_	_	_
21	resulted	result	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
22	in	in	ADP	IN	_	_	_	_	_
23	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
24	release	release	NOUN	NN	Number=Sing	_	_	_	_
25	of	of	ADP	IN	_	_	_	_	_
26	NF	NF	PROPN	NNP	Number=Sing	_	_	_	_
27	kappa	kappa	PROPN	NNP	Number=Sing	_	_	_	_
28	B	B	PROPN	NNP	Number=Sing	_	_	_	_
29	from	from	ADP	IN	_	_	_	_	_
30	I	I	PROPN	NNP	Number=Sing	_	_	_	_
31	kappa	kappa	PROPN	NNP	Number=Sing	_	_	_	_
32	B	B	PROPN	NNP	Number=Sing	_	_	_	_
33	alpha	alpha	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
34	,	,	PUNCT	,	_	_	_	_	_
35	indicating	indicate	VERB	VBG	VerbForm=Ger	_	_	_	_
36	that	that	SCONJ	IN	_	_	_	_	_
37	Cu2	cu2	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
38	+	+	SYM	SYM	_	_	_	_	_
39	interferes	interfere	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
40	with	with	ADP	IN	_	_	_	_	_
41	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
42	dissociation	dissociation	NOUN	NN	Number=Sing	_	_	_	_
43	of	of	ADP	IN	_	_	_	_	_
44	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
45	NF	NF	PROPN	NNP	Number=Sing	_	_	_	_
46	kappa	kappa	PROPN	NNP	Number=Sing	_	_	_	_
47	B	b	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
48	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
49	I	I	PRON	PRP	Case=Nom|Number=Sing|Person=1|PronType=Prs	_	_	_	_
50	kappa	kappa	X	FW	Foreign=Yes	_	_	_	_
51	B	b	ADJ	JJ	Degree=Pos	_	_	_	_
52	complex	complex	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
53	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 977
# text = Neither phosphorylation nor degradation of I kappa B alpha was observed upon TNF-alpha stimulation in the presence of Cu2+.
1	Neither	neither	DET	DT	_	_	_	_	_
2	phosphorylation	phosphorylation	NOUN	NN	Number=Sing	_	_	_	_
3	nor	nor	CCONJ	CC	_	_	_	_	_
4	degradation	degradation	NOUN	NN	Number=Sing	_	_	_	_
5	of	of	ADP	IN	_	_	_	_	_
6	I	I	PRON	PRP	Case=Nom|Number=Sing|Person=1|PronType=Prs	_	_	_	_
7	kappa	kappa	PROPN	NNP	Number=Sing	_	_	_	_
8	B	B	PROPN	NNP	Number=Sing	_	_	_	_
9	alpha	alpha	PROPN	NNP	Number=Sing	_	_	_	_
10	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
11	observed	observe	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
12	upon	upon	ADP	IN	_	_	_	_	_
13	TNF	TNF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
14	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
15	alpha	alpha	NOUN	NN	Number=Sing	_	_	_	_
16	stimulation	stimulation	NOUN	NN	Number=Sing	_	_	_	_
17	in	in	ADP	IN	_	_	_	_	_
18	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
19	presence	presence	NOUN	NN	Number=Sing	_	_	_	_
20	of	of	ADP	IN	_	_	_	_	_
21	Cu2	Cu2	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
22	+.	+.	NOUN	NN	Number=Sing	_	_	_	_

# sent_id = 978
# text = These results indicate that Cu2+ inhibits the release of NF kappa B by blockade of a signal leading to the phosphorylation of I kappa B alpha.
1	These	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
2	results	result	NOUN	NNS	Number=Plur	_	_	_	_
3	indicate	indicate	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
4	that	that	SCONJ	IN	_	_	_	_	_
5	Cu2	Cu2	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
6	+	+	SYM	SYM	_	_	_	_	_
7	inhibits	inhibits	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
8	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
9	release	release	NOUN	NN	Number=Sing	_	_	_	_
10	of	of	ADP	IN	_	_	_	_	_
11	NF	NF	PROPN	NNP	Number=Sing	_	_	_	_
12	kappa	kappa	PROPN	NNP	Number=Sing	_	_	_	_
13	B	b	PROPN	NNP	Number=Sing	_	_	_	_
14	by	by	ADP	IN	_	_	_	_	_
15	blockade	blockade	NOUN	NN	Number=Sing	_	_	_	_
16	of	of	ADP	IN	_	_	_	_	_
17	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
18	signal	signal	NOUN	NN	Number=Sing	_	_	_	_
19	leading	lead	VERB	VBG	VerbForm=Ger	_	_	_	_
20	to	to	ADP	IN	_	_	_	_	_
21	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
22	phosphorylation	phosphorylation	NOUN	NN	Number=Sing	_	_	_	_
23	of	of	ADP	IN	_	_	_	_	_
24	I	I	PRON	PRP	Case=Nom|Number=Sing|Person=1|PronType=Prs	_	_	_	_
25	kappa	kappa	PROPN	NNP	Number=Sing	_	_	_	_
26	B	B	PROPN	NNP	Number=Sing	_	_	_	_
27	alpha	alpha	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
28	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 979
# text = Document 003002358 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	003002358	003002358	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 980
# text = Vitamin D3- and retinoic acid-induced monocytic differentiation: interactions between the endogenous vitamin D3 receptor, retinoic acid receptors, and retinoid X receptors in U-937 cells.
1	Vitamin	Vitamin	PROPN	NNP	Number=Sing	_	_	_	_
2	D3	D3	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
3	-	-	PUNCT	,	_	_	_	_	_
4	and	and	CCONJ	CC	_	_	_	_	_
5	retinoic	retinoic	ADJ	JJ	Degree=Pos	_	_	_	_
6	acid	acid	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
7	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
8	induced	induce	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
9	monocytic	monocytic	ADJ	JJ	Degree=Pos	_	_	_	_
10	differentiation	differentiation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
11	:	:	PUNCT	:	_	_	_	_	_
12	interactions	interaction	NOUN	NNS	Number=Plur	_	_	_	_
13	between	between	ADP	IN	_	_	_	_	_
14	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
15	endogenous	endogenous	ADJ	JJ	Degree=Pos	_	_	_	_
16	vitamin	vitamin	NOUN	NN	Number=Sing	_	_	_	_
17	D3	D3	NOUN	NN	Number=Sing	_	_	_	_
18	receptor	receptor	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
19	,	,	PUNCT	,	_	_	_	_	_
20	retinoic	retinoic	ADJ	JJ	Degree=Pos	_	_	_	_
21	acid	acid	ADJ	JJ	Degree=Pos	_	_	_	_
22	receptors	receptor	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
23	,	,	PUNCT	,	_	_	_	_	_
24	and	and	CCONJ	CC	_	_	_	_	_
25	retinoid	retinoid	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
26	X	x	ADP	IN	_	_	_	_	_
27	receptors	receptor	NOUN	NNS	Number=Plur	_	_	_	_
28	in	in	ADP	IN	_	_	_	_	_
29	U	U	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
30	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
31	937	937	NUM	CD	NumType=Card	_	_	_	_
32	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
33	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 981
# text = Retinoic acid (RA) and 1,25 alpha-dihydroxycholecalciferol (VitD3) are potent regulators of hematopoletic differentiation.
1	Retinoic	Retinoic	ADJ	JJ	Degree=Pos	_	_	_	_
2	acid	acid	NOUN	NN	Number=Sing	_	_	_	_
3	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
4	RA	RA	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
5	)	)	PUNCT	-RRB-	_	_	_	_	_
6	and	and	CCONJ	CC	_	_	_	_	_
7	1,25	1,25	NUM	CD	NumType=Card	_	_	_	_
8	alpha-	alpha-	PUNCT	:	_	_	_	_	SpaceAfter=No
9	dihydroxycholecalciferol	dihydroxycholecalciferol	NOUN	NN	Number=Sing	_	_	_	_
10	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
11	VitD3	VitD3	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
12	)	)	PUNCT	-RRB-	_	_	_	_	_
13	are	be	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
14	potent	potent	ADJ	JJ	Degree=Pos	_	_	_	_
15	regulators	regulator	NOUN	NNS	Number=Plur	_	_	_	_
16	of	of	ADP	IN	_	_	_	_	_
17	hematopoletic	hematopoletic	ADJ	JJ	Degree=Pos	_	_	_	_
18	differentiation	differentiation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
19	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 982
# text = Yet, little is known as to how the RA and VitD3 receptor network operates in hematopoietic cells, and whether receptor interactions can explain the interplay between the RA- and VitD3-signaling pathways during differentiation.
1	Yet	yet	CCONJ	CC	_	_	_	_	SpaceAfter=No
2	,	,	PUNCT	,	_	_	_	_	_
3	little	little	ADJ	JJ	Degree=Pos	_	_	_	_
4	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
5	known	know	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
6	as	as	ADP	IN	_	_	_	_	_
7	to	to	SCONJ	IN	_	_	_	_	_
8	how	how	ADV	WRB	PronType=Int	_	_	_	_
9	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
10	RA	RA	PROPN	NNP	Number=Sing	_	_	_	_
11	and	and	CCONJ	CC	_	_	_	_	_
12	VitD3	VitD3	NUM	CD	NumType=Card	_	_	_	_
13	receptor	receptor	NOUN	NN	Number=Sing	_	_	_	_
14	network	network	NOUN	NN	Number=Sing	_	_	_	_
15	operates	operate	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
16	in	in	ADP	IN	_	_	_	_	_
17	hematopoietic	hematopoietic	ADJ	JJ	Degree=Pos	_	_	_	_
18	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
19	,	,	PUNCT	,	_	_	_	_	_
20	and	and	CCONJ	CC	_	_	_	_	_
21	whether	whether	SCONJ	IN	_	_	_	_	_
22	receptor	receptor	NOUN	NN	Number=Sing	_	_	_	_
23	interactions	interaction	NOUN	NNS	Number=Plur	_	_	_	_
24	can	can	AUX	MD	VerbForm=Fin	_	_	_	_
25	explain	explain	VERB	VB	VerbForm=Inf	_	_	_	_
26	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
27	interplay	interplay	NOUN	NN	Number=Sing	_	_	_	_
28	between	between	ADP	IN	_	_	_	_	_
29	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
30	RA	Ra	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
31	-	-	PUNCT	,	_	_	_	_	_
32	and	and	CCONJ	CC	_	_	_	_	_
33	VitD3	VitD3	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
34	-signaling	-signal	ADJ	JJ	Degree=Pos	_	_	_	_
35	pathways	pathway	NOUN	NNS	Number=Plur	_	_	_	_
36	during	during	ADP	IN	_	_	_	_	_
37	differentiation	differentiation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
38	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 983
# text = Therefore, we analyzed the expression, DNA binding, and transcriptional activity of the endogenous RA and VitD3 receptors [retinoic acid receptors (RARs), retinoid X receptors (RXRs), and VitD3 receptor (VDR)] in the U-937 cell line, in which RA and VitD3 induce distinct monocytic differentiation pathways.
1	Therefore	therefore	ADV	RB	_	_	_	_	SpaceAfter=No
2	,	,	PUNCT	,	_	_	_	_	_
3	we	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
4	analyzed	analyze	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
5	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
6	expression	expression	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
7	,	,	PUNCT	,	_	_	_	_	_
8	DNA	dna	NOUN	NN	Number=Sing	_	_	_	_
9	binding	binding	VERB	VBG	VerbForm=Ger	_	_	_	SpaceAfter=No
10	,	,	PUNCT	,	_	_	_	_	_
11	and	and	CCONJ	CC	_	_	_	_	_
12	transcriptional	transcriptional	ADJ	JJ	Degree=Pos	_	_	_	_
13	activity	activity	NOUN	NN	Number=Sing	_	_	_	_
14	of	of	ADP	IN	_	_	_	_	_
15	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
16	endogenous	endogenous	ADJ	JJ	Degree=Pos	_	_	_	_
17	RA	Ra	NOUN	NN	Number=Sing	_	_	_	_
18	and	and	CCONJ	CC	_	_	_	_	_
19	VitD3	VitD3	NOUN	NN	Number=Sing	_	_	_	_
20	receptors	receptor	NOUN	NNS	Number=Plur	_	_	_	_
21	[	[	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
22	retinoic	retinoic	ADJ	JJ	Degree=Pos	_	_	_	_
23	acid	acid	NOUN	NN	Number=Sing	_	_	_	_
24	receptors	receptor	NOUN	NNS	Number=Plur	_	_	_	_
25	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
26	RARs	RAR	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
27	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
28	,	,	PUNCT	,	_	_	_	_	_
29	retinoid	retinoid	VERB	VB	Mood=Imp|VerbForm=Fin	_	_	_	_
30	X	x	SYM	SYM	_	_	_	_	_
31	receptors	receptor	NOUN	NNS	Number=Plur	_	_	_	_
32	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
33	RXRs	RXR	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
34	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
35	,	,	PUNCT	,	_	_	_	_	_
36	and	and	CCONJ	CC	_	_	_	_	_
37	VitD3	VitD3	NUM	CD	NumType=Card	_	_	_	_
38	receptor	receptor	NOUN	NN	Number=Sing	_	_	_	_
39	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
40	VDR	VDR	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
41	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
42	]	]	PUNCT	-RRB-	_	_	_	_	_
43	in	in	ADP	IN	_	_	_	_	_
44	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
45	U	u	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
46	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
47	937	937	NUM	CD	NumType=Card	_	_	_	_
48	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
49	line	line	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
50	,	,	PUNCT	,	_	_	_	_	_
51	in	in	ADP	IN	_	_	_	_	_
52	which	which	PRON	WDT	PronType=Rel	_	_	_	_
53	RA	RA	PROPN	NNP	Number=Sing	_	_	_	_
54	and	and	CCONJ	CC	_	_	_	_	_
55	VitD3	VitD3	NUM	CD	NumType=Card	_	_	_	_
56	induce	induce	NOUN	NN	Number=Sing	_	_	_	_
57	distinct	distinct	ADJ	JJ	Degree=Pos	_	_	_	_
58	monocytic	monocytic	ADJ	JJ	Degree=Pos	_	_	_	_
59	differentiation	differentiation	NOUN	NN	Number=Sing	_	_	_	_
60	pathways	pathway	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
61	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 984
# text = VitD3 induction resulted in the formation of VDR/RXR DNA-binding complexes on both VitD3 response elements and RA response elements (RAREs).
1	VitD3	VitD3	NUM	CD	NumType=Card	_	_	_	_
2	induction	induction	NOUN	NN	Number=Sing	_	_	_	_
3	resulted	result	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
4	in	in	ADP	IN	_	_	_	_	_
5	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
6	formation	formation	NOUN	NN	Number=Sing	_	_	_	_
7	of	of	ADP	IN	_	_	_	_	_
8	VDR/RXR	VDR/RXR	PROPN	NNP	Number=Sing	_	_	_	_
9	DNA	dna	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
10	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
11	binding	binding	VERB	VBG	VerbForm=Ger	_	_	_	_
12	complexes	complex	NOUN	NNS	Number=Plur	_	_	_	_
13	on	on	ADP	IN	_	_	_	_	_
14	both	both	CCONJ	CC	_	_	_	_	_
15	VitD3	VitD3	NUM	CD	NumType=Card	_	_	_	_
16	response	response	NOUN	NN	Number=Sing	_	_	_	_
17	elements	element	NOUN	NNS	Number=Plur	_	_	_	_
18	and	and	CCONJ	CC	_	_	_	_	_
19	RA	RA	PROPN	NNP	Number=Sing	_	_	_	_
20	response	response	NOUN	NN	Number=Sing	_	_	_	_
21	elements	element	NOUN	NNS	Number=Plur	_	_	_	_
22	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
23	RAREs	RARE	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
24	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
25	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 985
# text = However, transcriptional activation was only observed from a VitD3 response element-driven reporter construct.
1	However	however	ADV	RB	_	_	_	_	SpaceAfter=No
2	,	,	PUNCT	,	_	_	_	_	_
3	transcriptional	transcriptional	ADJ	JJ	Degree=Pos	_	_	_	_
4	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
5	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
6	only	only	ADV	RB	_	_	_	_	_
7	observed	observe	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
8	from	from	ADP	IN	_	_	_	_	_
9	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
10	VitD3	VitD3	NUM	CD	NumType=Card	_	_	_	_
11	response	response	NOUN	NN	Number=Sing	_	_	_	_
12	element	element	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
13	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
14	driven	drive	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
15	reporter	reporter	NOUN	NN	Number=Sing	_	_	_	_
16	construct	construct	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
17	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 986
# text = Several DNA-binding complexes were detected on RAREs in undifferentiated cells.
1	Several	several	ADJ	JJ	Degree=Pos	_	_	_	_
2	DNA	dna	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
3	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
4	binding	binding	VERB	VBG	VerbForm=Ger	_	_	_	_
5	complexes	complex	NOUN	NNS	Number=Plur	_	_	_	_
6	were	be	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
7	detected	detect	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
8	on	on	ADP	IN	_	_	_	_	_
9	RAREs	RARE	NOUN	NNS	Number=Plur	_	_	_	_
10	in	in	ADP	IN	_	_	_	_	_
11	undifferentiated	undifferentiated	ADJ	JJ	Degree=Pos	_	_	_	_
12	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
13	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 987
# text = Stimulation by RA resulted in increased RAR beta/RXR DNA binding, activated RARE-dependent transcription, and increased expression of RAR-beta.
1	Stimulation	Stimulation	NOUN	NN	Number=Sing	_	_	_	_
2	by	by	ADP	IN	_	_	_	_	_
3	RA	RA	PROPN	NNP	Number=Sing	_	_	_	_
4	resulted	result	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
5	in	in	ADP	IN	_	_	_	_	_
6	increased	increase	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
7	RAR	RAR	PROPN	NNP	Number=Sing	_	_	_	_
8	beta	beta	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
9	/	/	PUNCT	,	_	_	_	_	SpaceAfter=No
10	RXR	RXR	PROPN	NNP	Number=Sing	_	_	_	_
11	DNA	Dna	NOUN	NN	Number=Sing	_	_	_	_
12	binding	binding	VERB	VBG	VerbForm=Ger	_	_	_	SpaceAfter=No
13	,	,	PUNCT	,	_	_	_	_	_
14	activated	activated	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
15	RARE	rare	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
16	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
17	dependent	dependent	ADJ	JJ	Degree=Pos	_	_	_	_
18	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
19	,	,	PUNCT	,	_	_	_	_	_
20	and	and	CCONJ	CC	_	_	_	_	_
21	increased	increase	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
22	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
23	of	of	ADP	IN	_	_	_	_	_
24	RAR	RAR	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
25	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
26	beta	beta	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
27	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 988
# text = Concomitant stimulation by VitD3 inhibited the RA-stimulated formation of RAR beta/RXR heterodimers, favoring VDR/RXR binding to the RARE.
1	Concomitant	Concomitant	ADJ	JJ	Degree=Pos	_	_	_	_
2	stimulation	stimulation	NOUN	NN	Number=Sing	_	_	_	_
3	by	by	ADP	IN	_	_	_	_	_
4	VitD3	VitD3	NUM	CD	NumType=Card	_	_	_	_
5	inhibited	inhibit	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
6	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
7	RA	RA	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
8	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
9	stimulated	stimulate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
10	formation	formation	NOUN	NN	Number=Sing	_	_	_	_
11	of	of	ADP	IN	_	_	_	_	_
12	RAR	RAR	PROPN	NNP	Number=Sing	_	_	_	_
13	beta	beta	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
14	/	/	PUNCT	,	_	_	_	_	SpaceAfter=No
15	RXR	RXR	PROPN	NNP	Number=Sing	_	_	_	_
16	heterodimers	heterodimer	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
17	,	,	PUNCT	,	_	_	_	_	_
18	favoring	favor	VERB	VBG	VerbForm=Ger	_	_	_	_
19	VDR	VDR	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
20	/	/	PUNCT	,	_	_	_	_	SpaceAfter=No
21	RXR	RXR	PROPN	NNP	Number=Sing	_	_	_	_
22	binding	bind	VERB	VBG	VerbForm=Ger	_	_	_	_
23	to	to	ADP	IN	_	_	_	_	_
24	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
25	RARE	rare	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
26	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 989
# text = Also, VitD3 inhibited the expression of CD23 and CD49f, characteristic markers of retinoid-induced U-937 cell differentiation.
1	Also	also	ADV	RB	_	_	_	_	SpaceAfter=No
2	,	,	PUNCT	,	_	_	_	_	_
3	VitD3	VitD3	NUM	CD	NumType=Card	_	_	_	_
4	inhibited	inhibit	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
5	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
6	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
7	of	of	ADP	IN	_	_	_	_	_
8	CD23	CD23	NOUN	NN	Number=Sing	_	_	_	_
9	and	and	CCONJ	CC	_	_	_	_	_
10	CD49f	CD49f	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
11	,	,	PUNCT	,	_	_	_	_	_
12	characteristic	characteristic	ADJ	JJ	Degree=Pos	_	_	_	_
13	markers	marker	NOUN	NNS	Number=Plur	_	_	_	_
14	of	of	ADP	IN	_	_	_	_	_
15	retinoid	retinoid	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	SpaceAfter=No
16	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
17	induced	induce	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
18	U	U	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
19	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
20	937	937	NUM	CD	NumType=Card	_	_	_	_
21	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
22	differentiation	differentiation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
23	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 990
# text = In contrast, neither the RA-stimulated, RARE-mediated transcription nor the induced RAR-beta expression was suppressed by VitD3, suggesting that VitD3 selectively inhibited the retinoid-induced differentiation program but not the RARE-mediated signal.
1	In	in	ADP	IN	_	_	_	_	_
2	contrast	contrast	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
3	,	,	PUNCT	,	_	_	_	_	_
4	neither	neither	CCONJ	CC	_	_	_	_	_
5	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
6	RA	Ra	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
7	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
8	stimulated	stimulate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	SpaceAfter=No
9	,	,	PUNCT	,	_	_	_	_	_
10	RARE	rare	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
11	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
12	mediated	mediate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
13	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
14	nor	nor	CCONJ	CC	_	_	_	_	_
15	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
16	induced	induce	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
17	RAR	Rar	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
18	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
19	beta	beta	NOUN	NN	Number=Sing	_	_	_	_
20	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
21	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
22	suppressed	suppress	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
23	by	by	ADP	IN	_	_	_	_	_
24	VitD3	VitD3	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
25	,	,	PUNCT	,	_	_	_	_	_
26	suggesting	suggest	VERB	VBG	VerbForm=Ger	_	_	_	_
27	that	that	SCONJ	IN	_	_	_	_	_
28	VitD3	VitD3	NUM	CD	NumType=Card	_	_	_	_
29	selectively	selectively	ADV	RB	_	_	_	_	_
30	inhibited	inhibit	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
31	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
32	retinoid	retinoid	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	SpaceAfter=No
33	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
34	induced	induce	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
35	differentiation	differentiation	NOUN	NN	Number=Sing	_	_	_	_
36	program	program	NOUN	NN	Number=Sing	_	_	_	_
37	but	but	CCONJ	CC	_	_	_	_	_
38	not	not	PART	RB	_	_	_	_	_
39	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
40	RARE	rare	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
41	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
42	mediated	mediate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
43	signal	signal	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
44	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 991
# text = These results demonstrate a complex role for VitD3 in modifying the retinoid differentiation pathway and may have implications for differentiation-inducing therapy of hematopoietic tumors.
1	These	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
2	results	result	NOUN	NNS	Number=Plur	_	_	_	_
3	demonstrate	demonstrate	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
4	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
5	complex	complex	ADJ	JJ	Degree=Pos	_	_	_	_
6	role	role	NOUN	NN	Number=Sing	_	_	_	_
7	for	for	ADP	IN	_	_	_	_	_
8	VitD3	VitD3	NUM	CD	NumType=Card	_	_	_	_
9	in	in	SCONJ	IN	_	_	_	_	_
10	modifying	modify	VERB	VBG	VerbForm=Ger	_	_	_	_
11	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
12	retinoid	retinoid	ADJ	JJ	Degree=Pos	_	_	_	_
13	differentiation	differentiation	NOUN	NN	Number=Sing	_	_	_	_
14	pathway	pathway	NOUN	NN	Number=Sing	_	_	_	_
15	and	and	CCONJ	CC	_	_	_	_	_
16	may	may	AUX	MD	VerbForm=Fin	_	_	_	_
17	have	have	VERB	VB	VerbForm=Inf	_	_	_	_
18	implications	implication	NOUN	NNS	Number=Plur	_	_	_	_
19	for	for	ADP	IN	_	_	_	_	_
20	differentiation	differentiation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
21	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
22	inducing	induce	VERB	VBG	VerbForm=Ger	_	_	_	_
23	therapy	therapy	NOUN	NN	Number=Sing	_	_	_	_
24	of	of	ADP	IN	_	_	_	_	_
25	hematopoietic	hematopoietic	ADJ	JJ	Degree=Pos	_	_	_	_
26	tumors	tumor	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
27	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 992
# text = Document 003002360 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	003002360	003002360	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 993
# text = Effects of overexpression of IL-1 receptor-associated kinase on NFkappaB activation, IL-2 production and stress-activated protein kinases in the murine T cell line EL4.
1	Effects	Effects	NOUN	NNS	Number=Plur	_	_	_	_
2	of	of	ADP	IN	_	_	_	_	_
3	overexpression	overexpression	NOUN	NN	Number=Sing	_	_	_	_
4	of	of	ADP	IN	_	_	_	_	_
5	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
6	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
7	1	1	NUM	CD	NumType=Card	_	_	_	_
8	receptor	receptor	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
9	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
10	associated	associate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
11	kinase	kinase	NOUN	NN	Number=Sing	_	_	_	_
12	on	on	ADP	IN	_	_	_	_	_
13	NFkappaB	NFkappaB	PROPN	NNP	Number=Sing	_	_	_	_
14	activation	activation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
15	,	,	PUNCT	,	_	_	_	_	_
16	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
17	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
18	2	2	NUM	CD	NumType=Card	_	_	_	_
19	production	production	NOUN	NN	Number=Sing	_	_	_	_
20	and	and	CCONJ	CC	_	_	_	_	_
21	stress	stress	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
22	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
23	activated	activate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
24	protein	protein	NOUN	NN	Number=Sing	_	_	_	_
25	kinases	kinase	NOUN	NNS	Number=Plur	_	_	_	_
26	in	in	ADP	IN	_	_	_	_	_
27	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
28	murine	murine	PROPN	NNP	Number=Sing	_	_	_	_
29	T	t	PROPN	NNP	Number=Sing	_	_	_	_
30	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
31	line	line	NOUN	NN	Number=Sing	_	_	_	_
32	EL4	El4	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
33	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 994
# text = The association and activation of the IL-1 receptor-associated protein kinase (IRAK) to the IL-1 receptor complex is one of the earliest events detectable in IL-1 signal transduction.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	association	association	NOUN	NN	Number=Sing	_	_	_	_
3	and	and	CCONJ	CC	_	_	_	_	_
4	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
5	of	of	ADP	IN	_	_	_	_	_
6	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
7	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
8	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
9	1	1	NUM	CD	NumType=Card	_	_	_	_
10	receptor	receptor	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
11	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
12	associated	associate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
13	protein	protein	NOUN	NN	Number=Sing	_	_	_	_
14	kinase	kinase	NOUN	NN	Number=Sing	_	_	_	_
15	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
16	IRAK	IRAK	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
17	)	)	PUNCT	-RRB-	_	_	_	_	_
18	to	to	ADP	IN	_	_	_	_	_
19	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
20	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
21	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
22	1	1	NUM	CD	NumType=Card	_	_	_	_
23	receptor	receptor	NOUN	NN	Number=Sing	_	_	_	_
24	complex	complex	NOUN	NN	Number=Sing	_	_	_	_
25	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
26	one	one	NUM	CD	NumType=Card	_	_	_	_
27	of	of	ADP	IN	_	_	_	_	_
28	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
29	earliest	earliest	ADJ	JJS	Degree=Sup	_	_	_	_
30	events	event	NOUN	NNS	Number=Plur	_	_	_	_
31	detectable	detectable	ADJ	JJ	Degree=Pos	_	_	_	_
32	in	in	ADP	IN	_	_	_	_	_
33	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
34	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
35	1	1	NUM	CD	NumType=Card	_	_	_	_
36	signal	signal	NOUN	NN	Number=Sing	_	_	_	_
37	transduction	transduction	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
38	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 995
# text = We generated permanent clones of the murine T cell line EL4 6.1 overexpressing human (h)IRAK to evaluate the role of this kinase in IL-1 signaling.
1	We	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
2	generated	generate	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
3	permanent	permanent	ADJ	JJ	Degree=Pos	_	_	_	_
4	clones	clone	NOUN	NNS	Number=Plur	_	_	_	_
5	of	of	ADP	IN	_	_	_	_	_
6	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
7	murine	murine	PROPN	NNP	Number=Sing	_	_	_	_
8	T	t	PROPN	NNP	Number=Sing	_	_	_	_
9	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
10	line	line	NOUN	NN	Number=Sing	_	_	_	_
11	EL4	EL4	NUM	CD	NumType=Card	_	_	_	_
12	6.1	6.1	NUM	CD	NumType=Card	_	_	_	_
13	overexpressing	overexpresse	VERB	VBG	VerbForm=Ger	_	_	_	_
14	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
15	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
16	h	h	INTJ	UH	_	_	_	_	SpaceAfter=No
17	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
18	IRAK	IRAK	PROPN	NNP	Number=Sing	_	_	_	_
19	to	to	PART	TO	_	_	_	_	_
20	evaluate	evaluate	VERB	VB	VerbForm=Inf	_	_	_	_
21	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
22	role	role	NOUN	NN	Number=Sing	_	_	_	_
23	of	of	ADP	IN	_	_	_	_	_
24	this	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
25	kinase	kinase	NOUN	NN	Number=Sing	_	_	_	_
26	in	in	ADP	IN	_	_	_	_	_
27	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
28	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
29	1	1	NUM	CD	NumType=Card	_	_	_	_
30	signaling	signaling	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
31	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 996
# text = Overexpression of hIRAK enhanced IL-1-stimulated activation of the transcription factor NFkappaB, whereas a truncated form (N-IRAK) specifically inhibited IL-1-dependent NFkappaB activity.
1	Overexpression	Overexpression	NOUN	NN	Number=Sing	_	_	_	_
2	of	of	ADP	IN	_	_	_	_	_
3	hIRAK	hIRAK	PROPN	NNP	Number=Sing	_	_	_	_
4	enhanced	enhance	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
5	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
6	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
7	1	1	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
8	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
9	stimulated	stimulate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
10	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
11	of	of	ADP	IN	_	_	_	_	_
12	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
13	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
14	factor	factor	NOUN	NN	Number=Sing	_	_	_	_
15	NFkappaB	NFkappaB	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
16	,	,	PUNCT	,	_	_	_	_	_
17	whereas	whereas	SCONJ	IN	_	_	_	_	_
18	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
19	truncated	truncate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
20	form	form	NOUN	NN	Number=Sing	_	_	_	_
21	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
22	N	N	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
23	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
24	IRAK	IRAK	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
25	)	)	PUNCT	-RRB-	_	_	_	_	_
26	specifically	specifically	ADV	RB	_	_	_	_	_
27	inhibited	inhibit	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
28	IL	IL	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
29	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
30	1	1	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
31	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
32	dependent	dependent	ADJ	JJ	Degree=Pos	_	_	_	_
33	NFkappaB	Nfkappab	ADJ	JJ	Degree=Pos	_	_	_	_
34	activity	activity	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
35	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 997
# text = In clones stably overexpressing hIRAK a weak constitutive activation of NFkappaB correlated with a low basal IL-2 production which was enhanced in an IL-1-dependent manner.
1	In	in	ADP	IN	_	_	_	_	_
2	clones	clone	NOUN	NNS	Number=Plur	_	_	_	_
3	stably	stably	ADV	RB	_	_	_	_	_
4	overexpressing	overexpresse	VERB	VBG	VerbForm=Ger	_	_	_	_
5	hIRAK	hIRAK	PROPN	NNP	Number=Sing	_	_	_	_
6	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
7	weak	weak	ADJ	JJ	Degree=Pos	_	_	_	_
8	constitutive	constitutive	ADJ	JJ	Degree=Pos	_	_	_	_
9	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
10	of	of	ADP	IN	_	_	_	_	_
11	NFkappaB	NFkappaB	PROPN	NNP	Number=Sing	_	_	_	_
12	correlated	correlate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
13	with	with	ADP	IN	_	_	_	_	_
14	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
15	low	low	ADJ	JJ	Degree=Pos	_	_	_	_
16	basal	basal	NOUN	NN	Number=Sing	_	_	_	_
17	IL	Il	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
18	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
19	2	2	NUM	CD	NumType=Card	_	_	_	_
20	production	production	NOUN	NN	Number=Sing	_	_	_	_
21	which	which	PRON	WDT	PronType=Rel	_	_	_	_
22	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
23	enhanced	enhance	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
24	in	in	ADP	IN	_	_	_	_	_
25	an	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
26	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
27	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
28	1	1	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
29	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
30	dependent	dependent	ADJ	JJ	Degree=Pos	_	_	_	_
31	manner	manner	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
32	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 998
# text = Compared to the parental cell line the dose-response curve of IL-1-induced IL-2 production was shifted in both potency and efficacy.
1	Compared	compare	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
2	to	to	ADP	IN	_	_	_	_	_
3	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
4	parental	parental	ADJ	JJ	Degree=Pos	_	_	_	_
5	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
6	line	line	NOUN	NN	Number=Sing	_	_	_	_
7	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
8	dose	dose	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
9	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
10	response	response	NOUN	NN	Number=Sing	_	_	_	_
11	curve	curve	NOUN	NN	Number=Sing	_	_	_	_
12	of	of	ADP	IN	_	_	_	_	_
13	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
14	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
15	1	1	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
16	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
17	induced	induce	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
18	IL	Il	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
19	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
20	2	2	NUM	CD	NumType=Card	_	_	_	_
21	production	production	NOUN	NN	Number=Sing	_	_	_	_
22	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
23	shifted	shift	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
24	in	in	ADP	IN	_	_	_	_	_
25	both	both	DET	DT	_	_	_	_	_
26	potency	potency	NOUN	NN	Number=Sing	_	_	_	_
27	and	and	CCONJ	CC	_	_	_	_	_
28	efficacy	efficacy	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
29	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 999
# text = These results demonstrate that IRAK directly triggers NFkappaB-mediated gene expression in EL4 cells.
1	These	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
2	results	result	NOUN	NNS	Number=Plur	_	_	_	_
3	demonstrate	demonstrate	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
4	that	that	SCONJ	IN	_	_	_	_	_
5	IRAK	IRAK	PROPN	NNP	Number=Sing	_	_	_	_
6	directly	directly	ADV	RB	_	_	_	_	_
7	triggers	trigger	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
8	NFkappaB	NFkappaB	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
9	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
10	mediated	mediate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
11	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
12	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
13	in	in	ADP	IN	_	_	_	_	_
14	EL4	EL4	PROPN	NNP	Number=Sing	_	_	_	_
15	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
16	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1000
# text = Qualitatively different effects were observed for the IL-1-induced activation of stress-activated protein (SAP) kinases: permanent overexpression of IRAK did not affect the dose dependence but prolonged the kinetics of IL-1-induced activation of SAP kinases, suggesting that this signaling branch may be regulated by distinct mechanisms.
1	Qualitatively	Qualitatively	ADV	RB	_	_	_	_	_
2	different	different	ADJ	JJ	Degree=Pos	_	_	_	_
3	effects	effect	NOUN	NNS	Number=Plur	_	_	_	_
4	were	be	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
5	observed	observe	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
6	for	for	ADP	IN	_	_	_	_	_
7	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
8	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
9	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
10	1	1	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
11	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
12	induced	induce	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
13	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
14	of	of	ADP	IN	_	_	_	_	_
15	stress	stress	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
16	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
17	activated	activate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
18	protein	protein	NOUN	NN	Number=Sing	_	_	_	_
19	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
20	SAP	sap	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
21	)	)	PUNCT	-RRB-	_	_	_	_	_
22	kinases	kinase	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
23	:	:	PUNCT	:	_	_	_	_	_
24	permanent	permanent	ADJ	JJ	Degree=Pos	_	_	_	_
25	overexpression	overexpression	NOUN	NN	Number=Sing	_	_	_	_
26	of	of	ADP	IN	_	_	_	_	_
27	IRAK	IRAK	PROPN	NNP	Number=Sing	_	_	_	_
28	did	do	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
29	not	not	PART	RB	_	_	_	_	_
30	affect	affect	VERB	VB	VerbForm=Inf	_	_	_	_
31	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
32	dose	dose	NOUN	NN	Number=Sing	_	_	_	_
33	dependence	dependence	NOUN	NN	Number=Sing	_	_	_	_
34	but	but	CCONJ	CC	_	_	_	_	_
35	prolonged	prolong	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
36	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
37	kinetics	kinetic	NOUN	NNS	Number=Plur	_	_	_	_
38	of	of	ADP	IN	_	_	_	_	_
39	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
40	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
41	1	1	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
42	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
43	induced	induce	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
44	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
45	of	of	ADP	IN	_	_	_	_	_
46	SAP	sap	NOUN	NN	Number=Sing	_	_	_	_
47	kinases	kinase	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
48	,	,	PUNCT	,	_	_	_	_	_
49	suggesting	suggest	VERB	VBG	VerbForm=Ger	_	_	_	_
50	that	that	SCONJ	IN	_	_	_	_	_
51	this	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
52	signaling	signaling	NOUN	NN	Number=Sing	_	_	_	_
53	branch	branch	NOUN	NN	Number=Sing	_	_	_	_
54	may	may	AUX	MD	VerbForm=Fin	_	_	_	_
55	be	be	AUX	VB	VerbForm=Inf	_	_	_	_
56	regulated	regulate	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
57	by	by	ADP	IN	_	_	_	_	_
58	distinct	distinct	ADJ	JJ	Degree=Pos	_	_	_	_
59	mechanisms	mechanism	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
60	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 1001
# text = Document 003002362 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	003002362	003002362	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 1002
# text = Inhibition of p105 processing by NF-kappaB proteins in transiently transfected cells.
1	Inhibition	Inhibition	NOUN	NN	Number=Sing	_	_	_	_
2	of	of	ADP	IN	_	_	_	_	_
3	p105	p105	NUM	CD	NumType=Card	_	_	_	_
4	processing	processing	VERB	VBG	VerbForm=Ger	_	_	_	_
5	by	by	ADP	IN	_	_	_	_	_
6	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
7	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
8	kappaB	kappaB	PROPN	NNP	Number=Sing	_	_	_	_
9	proteins	protein	NOUN	NNS	Number=Plur	_	_	_	_
10	in	in	ADP	IN	_	_	_	_	_
11	transiently	transiently	ADV	RB	_	_	_	_	_
12	transfected	transfect	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
13	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
14	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 1003
# text = Regulation of the transcription factor NF-kappaB involves proteasome-mediated processing of the NF-kappaB1 p105 precursor protein, which generates the p50 subunit of NF-kappaB.
1	Regulation	regulation	NOUN	NN	Number=Sing	_	_	_	_
2	of	of	ADP	IN	_	_	_	_	_
3	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
4	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
5	factor	factor	NOUN	NN	Number=Sing	_	_	_	_
6	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
7	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
8	kappaB	kappaB	PROPN	NNP	Number=Sing	_	_	_	_
9	involves	involve	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
10	proteasome	proteasome	ADV	RB	_	_	_	_	SpaceAfter=No
11	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
12	mediated	mediate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
13	processing	processing	NOUN	NN	Number=Sing	_	_	_	_
14	of	of	ADP	IN	_	_	_	_	_
15	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
16	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
17	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
18	kappaB1	kappaB1	PROPN	NNP	Number=Sing	_	_	_	_
19	p105	p105	NOUN	NN	Number=Sing	_	_	_	_
20	precursor	precursor	NOUN	NN	Number=Sing	_	_	_	_
21	protein	protein	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
22	,	,	PUNCT	,	_	_	_	_	_
23	which	which	PRON	WDT	PronType=Rel	_	_	_	_
24	generates	generate	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
25	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
26	p50	p50	NOUN	NN	Number=Sing	_	_	_	_
27	subunit	subunit	NOUN	NN	Number=Sing	_	_	_	_
28	of	of	ADP	IN	_	_	_	_	_
29	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
30	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
31	kappaB	kappaB	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
32	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1004
# text = The processing of p105 occurs constitutively in vivo but can be markedly enhanced by various cellular activation agents, although the underlying regulatory mechanism is not yet clear.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	processing	processing	NOUN	NN	Number=Sing	_	_	_	_
3	of	of	ADP	IN	_	_	_	_	_
4	p105	p105	NUM	CD	NumType=Card	_	_	_	_
5	occurs	occur	NOUN	NNS	Number=Plur	_	_	_	_
6	constitutively	constitutively	ADV	RB	_	_	_	_	_
7	in	in	ADP	IN	_	_	_	_	_
8	vivo	vivo	NOUN	NN	Number=Sing	_	_	_	_
9	but	but	CCONJ	CC	_	_	_	_	_
10	can	can	AUX	MD	VerbForm=Fin	_	_	_	_
11	be	be	AUX	VB	VerbForm=Inf	_	_	_	_
12	markedly	markedly	ADV	RB	_	_	_	_	_
13	enhanced	enhance	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
14	by	by	ADP	IN	_	_	_	_	_
15	various	various	ADJ	JJ	Degree=Pos	_	_	_	_
16	cellular	cellular	ADJ	JJ	Degree=Pos	_	_	_	_
17	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
18	agents	agent	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
19	,	,	PUNCT	,	_	_	_	_	_
20	although	although	SCONJ	IN	_	_	_	_	_
21	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
22	underlying	underlying	ADJ	JJ	Degree=Pos	_	_	_	_
23	regulatory	regulatory	ADJ	JJ	Degree=Pos	_	_	_	_
24	mechanism	mechanism	NOUN	NN	Number=Sing	_	_	_	_
25	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
26	not	not	PART	RB	_	_	_	_	_
27	yet	yet	ADV	RB	_	_	_	_	_
28	clear	clear	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
29	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1005
# text = In the present study, we demonstrate that signal-mediated induction of p105 processing in human T cells is associated with de novo synthesis of this precursor protein.
1	In	in	ADP	IN	_	_	_	_	_
2	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
3	present	present	ADJ	JJ	Degree=Pos	_	_	_	_
4	study	study	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
5	,	,	PUNCT	,	_	_	_	_	_
6	we	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
7	demonstrate	demonstrate	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
8	that	that	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
9	signal	signal	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
10	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
11	mediated	mediate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
12	induction	induction	NOUN	NN	Number=Sing	_	_	_	_
13	of	of	ADP	IN	_	_	_	_	_
14	p105	p105	NUM	CD	NumType=Card	_	_	_	_
15	processing	processing	NOUN	NN	Number=Sing	_	_	_	_
16	in	in	ADP	IN	_	_	_	_	_
17	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
18	T	T	PROPN	NNP	Number=Sing	_	_	_	_
19	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
20	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
21	associated	associate	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
22	with	with	ADP	IN	_	_	_	_	_
23	de	de	NOUN	NN	Number=Sing	_	_	_	_
24	novo	novo	NOUN	NN	Number=Sing	_	_	_	_
25	synthesis	synthesis	NOUN	NN	Number=Sing	_	_	_	_
26	of	of	ADP	IN	_	_	_	_	_
27	this	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
28	precursor	precursor	NOUN	NN	Number=Sing	_	_	_	_
29	protein	protein	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
30	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1006
# text = Transient transfection studies performed in COS7 cells revealed that the newly synthesized p105 protein appears to be more rapidly processed compared to its accumulated form that is already associated with the processed product p50.
1	Transient	Transient	ADJ	JJ	Degree=Pos	_	_	_	_
2	transfection	transfection	NOUN	NN	Number=Sing	_	_	_	_
3	studies	study	NOUN	NNS	Number=Plur	_	_	_	_
4	performed	perform	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
5	in	in	ADP	IN	_	_	_	_	_
6	COS7	COS7	NUM	CD	NumType=Card	_	_	_	_
7	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
8	revealed	reveal	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
9	that	that	SCONJ	IN	_	_	_	_	_
10	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
11	newly	newly	ADV	RB	_	_	_	_	_
12	synthesized	synthesize	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
13	p105	p105	NUM	CD	NumType=Card	_	_	_	_
14	protein	protein	NOUN	NN	Number=Sing	_	_	_	_
15	appears	appear	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
16	to	to	PART	TO	_	_	_	_	_
17	be	be	AUX	VB	VerbForm=Inf	_	_	_	_
18	more	more	ADV	RBR	_	_	_	_	_
19	rapidly	rapidly	ADV	RB	_	_	_	_	_
20	processed	process	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
21	compared	compare	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
22	to	to	ADP	IN	_	_	_	_	_
23	its	its	PRON	PRP$	Gender=Neut|Number=Sing|Person=3|Poss=Yes|PronType=Prs	_	_	_	_
24	accumulated	accumulate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
25	form	form	NOUN	NN	Number=Sing	_	_	_	_
26	that	that	PRON	WDT	PronType=Rel	_	_	_	_
27	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
28	already	already	ADV	RB	_	_	_	_	_
29	associated	associate	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
30	with	with	ADP	IN	_	_	_	_	_
31	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
32	processed	process	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
33	product	product	NOUN	NN	Number=Sing	_	_	_	_
34	p50	p50	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
35	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1007
# text = Interestingly, the processing rate of p105 is markedly inhibited in cells co-transfected with p50 or other NF-kappaB subunits, including RelA and c-Rel, that physically interact with p105.
1	Interestingly	Interestingly	ADV	RB	_	_	_	_	SpaceAfter=No
2	,	,	PUNCT	,	_	_	_	_	_
3	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
4	processing	processing	VERB	VBG	VerbForm=Ger	_	_	_	_
5	rate	rate	NOUN	NN	Number=Sing	_	_	_	_
6	of	of	ADP	IN	_	_	_	_	_
7	p105	p105	NOUN	NN	Number=Sing	_	_	_	_
8	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
9	markedly	markedly	ADV	RB	_	_	_	_	_
10	inhibited	inhibit	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
11	in	in	ADP	IN	_	_	_	_	_
12	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
13	co-transfected	co-transfect	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
14	with	with	ADP	IN	_	_	_	_	_
15	p50	p50	NOUN	NN	Number=Sing	_	_	_	_
16	or	or	CCONJ	CC	_	_	_	_	_
17	other	other	ADJ	JJ	Degree=Pos	_	_	_	_
18	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
19	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
20	kappaB	kappaB	PROPN	NNP	Number=Sing	_	_	_	_
21	subunits	subunit	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
22	,	,	PUNCT	,	_	_	_	_	_
23	including	include	VERB	VBG	VerbForm=Ger	_	_	_	_
24	RelA	Rela	NOUN	NN	Number=Sing	_	_	_	_
25	and	and	CCONJ	CC	_	_	_	_	_
26	c	c	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
27	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
28	Rel	Rel	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
29	,	,	PUNCT	,	_	_	_	_	_
30	that	that	SCONJ	IN	_	_	_	_	_
31	physically	physically	ADV	RB	_	_	_	_	_
32	interact	interact	VERB	VB	VerbForm=Inf	_	_	_	_
33	with	with	ADP	IN	_	_	_	_	_
34	p105	p105	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
35	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1008
# text = These findings suggest that the processing of p105 is subject to negative regulation by the various NF-kappaB subunits.
1	These	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
2	findings	finding	NOUN	NNS	Number=Plur	_	_	_	_
3	suggest	suggest	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
4	that	that	SCONJ	IN	_	_	_	_	_
5	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
6	processing	processing	NOUN	NN	Number=Sing	_	_	_	_
7	of	of	ADP	IN	_	_	_	_	_
8	p105	p105	NOUN	NN	Number=Sing	_	_	_	_
9	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
10	subject	subject	ADJ	JJ	Degree=Pos	_	_	_	_
11	to	to	ADP	IN	_	_	_	_	_
12	negative	negative	ADJ	JJ	Degree=Pos	_	_	_	_
13	regulation	regulation	NOUN	NN	Number=Sing	_	_	_	_
14	by	by	ADP	IN	_	_	_	_	_
15	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
16	various	various	ADJ	JJ	Degree=Pos	_	_	_	_
17	NF	NF	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
18	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
19	kappaB	kappaB	NOUN	NN	Number=Sing	_	_	_	_
20	subunits	subunit	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
21	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1009
# text = We further demonstrate that p105 undergoes degradation in lipopolysaccharide-stimulated human monocytic cells.
1	We	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
2	further	further	ADV	RB	_	_	_	_	_
3	demonstrate	demonstrate	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
4	that	that	SCONJ	IN	_	_	_	_	_
5	p105	p105	NUM	CD	NumType=Card	_	_	_	_
6	undergoes	undergo	NOUN	NNS	Number=Plur	_	_	_	_
7	degradation	degradation	NOUN	NN	Number=Sing	_	_	_	_
8	in	in	ADP	IN	_	_	_	_	_
9	lipopolysaccharide-stimulated	lipopolysaccharide-stimulated	ADJ	JJ	Degree=Pos	_	_	_	_
10	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
11	monocytic	monocytic	ADJ	JJ	Degree=Pos	_	_	_	_
12	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
13	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1010
# text = However, the inducible degradation of p105 is not coupled with the generation of p50.
1	However	however	ADV	RB	_	_	_	_	SpaceAfter=No
2	,	,	PUNCT	,	_	_	_	_	_
3	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
4	inducible	inducible	ADJ	JJ	Degree=Pos	_	_	_	_
5	degradation	degradation	NOUN	NN	Number=Sing	_	_	_	_
6	of	of	ADP	IN	_	_	_	_	_
7	p105	p105	NUM	CD	NumType=Card	_	_	_	_
8	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
9	not	not	PART	RB	_	_	_	_	_
10	coupled	couple	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
11	with	with	ADP	IN	_	_	_	_	_
12	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
13	generation	generation	NOUN	NN	Number=Sing	_	_	_	_
14	of	of	ADP	IN	_	_	_	_	_
15	p50	p50	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
16	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1011
# text = Together, these studies demonstrate that the processing and inducible degradation of p105 are differentially regulated.
1	Together	together	ADV	RB	_	_	_	_	SpaceAfter=No
2	,	,	PUNCT	,	_	_	_	_	_
3	these	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
4	studies	study	NOUN	NNS	Number=Plur	_	_	_	_
5	demonstrate	demonstrate	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
6	that	that	SCONJ	IN	_	_	_	_	_
7	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
8	processing	processing	NOUN	NN	Number=Sing	_	_	_	_
9	and	and	CCONJ	CC	_	_	_	_	_
10	inducible	inducible	ADJ	JJ	Degree=Pos	_	_	_	_
11	degradation	degradation	NOUN	NN	Number=Sing	_	_	_	_
12	of	of	ADP	IN	_	_	_	_	_
13	p105	p105	NOUN	NN	Number=Sing	_	_	_	_
14	are	be	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
15	differentially	differentially	ADV	RB	_	_	_	_	_
16	regulated	regulate	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	SpaceAfter=No
17	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 1012
# text = Document 003002363 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	003002363	003002363	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 1013
# text = The role of jun and fos gene family members in 12-O-tetradecanoylphorbol-13-acetate induced hemopoietic differentiation.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	role	role	NOUN	NN	Number=Sing	_	_	_	_
3	of	of	ADP	IN	_	_	_	_	_
4	jun	jun	NOUN	NN	Number=Sing	_	_	_	_
5	and	and	CCONJ	CC	_	_	_	_	_
6	fos	fo	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
7	gene	gene	ADJ	JJ	Degree=Pos	_	_	_	_
8	family	family	NOUN	NN	Number=Sing	_	_	_	_
9	members	member	NOUN	NNS	Number=Plur	_	_	_	_
10	in	in	ADP	IN	_	_	_	_	_
11	12	12	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
12	-	-	SYM	SYM	_	_	_	_	SpaceAfter=No
13	O	of	ADP	IN	Abbr=Yes	_	_	_	SpaceAfter=No
14	-tetradecanoylphorbol	-tetradecanoylphorbol	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
15	-13-acetate	-13-acetate	NOUN	NN	Number=Sing	_	_	_	_
16	induced	induce	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
17	hemopoietic	hemopoietic	ADJ	JJ	Degree=Pos	_	_	_	_
18	differentiation	differentiation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
19	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 1014
# text = Terminal differentiation of the leukemic cell lines U-937 and HL-60 by 12-O-tetradecanoylphorbol-13-acetate is accompanied by marked changes in gene expression.
1	Terminal	Terminal	NOUN	NN	Number=Sing	_	_	_	_
2	differentiation	differentiation	NOUN	NN	Number=Sing	_	_	_	_
3	of	of	ADP	IN	_	_	_	_	_
4	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
5	leukemic	leukemic	ADJ	JJ	Degree=Pos	_	_	_	_
6	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
7	lines	line	NOUN	NNS	Number=Plur	_	_	_	_
8	U-	U-	PUNCT	:	_	_	_	_	SpaceAfter=No
9	937	937	NUM	CD	NumType=Card	_	_	_	_
10	and	and	CCONJ	CC	_	_	_	_	_
11	HL	Hl	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
12	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
13	60	60	NUM	CD	NumType=Card	_	_	_	_
14	by	by	ADP	IN	_	_	_	_	_
15	12-O-tetradecanoylphorbol	12-O-tetradecanoylphorbol	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
16	-13-acetate	-13-acetate	NOUN	NN	Number=Sing	_	_	_	_
17	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
18	accompanied	accompany	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
19	by	by	ADP	IN	_	_	_	_	_
20	marked	mark	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
21	changes	change	NOUN	NNS	Number=Plur	_	_	_	_
22	in	in	ADP	IN	_	_	_	_	_
23	gene	gene	ADJ	JJ	Degree=Pos	_	_	_	_
24	expression	expression	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
25	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1015
# text = In this study, we demonstrate that the expression of jun and fos gene family members is induced with variable kinetics during 12-O-tetradecanoylphorbol-13-acetate induced differentiation, with c-jun expression best paralleling differentiation.
1	In	in	ADP	IN	_	_	_	_	_
2	this	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
3	study	study	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
4	,	,	PUNCT	,	_	_	_	_	_
5	we	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
6	demonstrate	demonstrate	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
7	that	that	SCONJ	IN	_	_	_	_	_
8	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
9	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
10	of	of	ADP	IN	_	_	_	_	_
11	jun	jun	NOUN	NN	Number=Sing	_	_	_	_
12	and	and	CCONJ	CC	_	_	_	_	_
13	fos	fo	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
14	gene	gene	ADJ	JJ	Degree=Pos	_	_	_	_
15	family	family	NOUN	NN	Number=Sing	_	_	_	_
16	members	member	NOUN	NNS	Number=Plur	_	_	_	_
17	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
18	induced	induce	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
19	with	with	ADP	IN	_	_	_	_	_
20	variable	variable	ADJ	JJ	Degree=Pos	_	_	_	_
21	kinetics	kinetic	NOUN	NNS	Number=Plur	_	_	_	_
22	during	during	ADP	IN	_	_	_	_	_
23	12-O-tetradecanoylphorbol	12-O-tetradecanoylphorbol	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
24	-13	-13	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
25	-acetate	-acetate	ADJ	JJ	Degree=Pos	_	_	_	_
26	induced	induce	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
27	differentiation	differentiation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
28	,	,	PUNCT	,	_	_	_	_	_
29	with	with	ADP	IN	_	_	_	_	_
30	c-	c-	SYM	NFP	_	_	_	_	SpaceAfter=No
31	jun	jun	NOUN	NN	Number=Sing	_	_	_	_
32	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
33	best	best	ADJ	JJS	Degree=Sup	_	_	_	_
34	paralleling	paralleling	NOUN	NN	Number=Sing	_	_	_	_
35	differentiation	differentiation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
36	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1016
# text = The generation of AP-1 complexes, as measured by DNA binding activity, closely parallels morphological differentiation.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	generation	generation	NOUN	NN	Number=Sing	_	_	_	_
3	of	of	ADP	IN	_	_	_	_	_
4	AP	ap	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
5	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
6	1	1	NUM	CD	NumType=Card	_	_	_	_
7	complexes	complexe	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
8	,	,	PUNCT	,	_	_	_	_	_
9	as	as	SCONJ	IN	_	_	_	_	_
10	measured	measure	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
11	by	by	ADP	IN	_	_	_	_	_
12	DNA	dna	NOUN	NN	Number=Sing	_	_	_	_
13	binding	binding	VERB	VBG	VerbForm=Ger	_	_	_	_
14	activity	activity	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
15	,	,	PUNCT	,	_	_	_	_	_
16	closely	closely	ADV	RB	_	_	_	_	_
17	parallels	parallel	NOUN	NNS	Number=Plur	_	_	_	_
18	morphological	morphological	ADJ	JJ	Degree=Pos	_	_	_	_
19	differentiation	differentiation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
20	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1017
# text = Furthermore, the ability of these complexes to regulate gene expression is demonstrated by increased transcription from an AP-1 driven reporter construct and marked increases in the expression of endogenous AP-1 regulated genes.
1	Furthermore	furthermore	ADV	RB	_	_	_	_	SpaceAfter=No
2	,	,	PUNCT	,	_	_	_	_	_
3	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
4	ability	ability	NOUN	NN	Number=Sing	_	_	_	_
5	of	of	ADP	IN	_	_	_	_	_
6	these	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
7	complexes	complexe	NOUN	NNS	Number=Plur	_	_	_	_
8	to	to	PART	TO	_	_	_	_	_
9	regulate	regulate	VERB	VB	VerbForm=Inf	_	_	_	_
10	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
11	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
12	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
13	demonstrated	demonstrate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
14	by	by	ADP	IN	_	_	_	_	_
15	increased	increase	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
16	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
17	from	from	ADP	IN	_	_	_	_	_
18	an	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
19	AP	ap	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
20	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
21	1	1	NUM	CD	NumType=Card	_	_	_	_
22	driven	driven	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
23	reporter	reporter	NOUN	NN	Number=Sing	_	_	_	_
24	construct	construct	NOUN	NN	Number=Sing	_	_	_	_
25	and	and	CCONJ	CC	_	_	_	_	_
26	marked	mark	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
27	increases	increase	NOUN	NNS	Number=Plur	_	_	_	_
28	in	in	ADP	IN	_	_	_	_	_
29	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
30	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
31	of	of	ADP	IN	_	_	_	_	_
32	endogenous	endogenous	ADJ	JJ	Degree=Pos	_	_	_	_
33	AP	ap	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
34	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
35	1	1	NUM	CD	NumType=Card	_	_	_	_
36	regulated	regulate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
37	genes	gene	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
38	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1018
# text = Differentiation assays using water soluble phorbol esters reveal that differentiation becomes irreversible soon after AP-1 appears.
1	Differentiation	Differentiation	NOUN	NN	Number=Sing	_	_	_	_
2	assays	assay	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
3	using	use	VERB	VBG	VerbForm=Ger	_	_	_	_
4	water	water	NOUN	NN	Number=Sing	_	_	_	_
5	soluble	soluble	ADJ	JJ	Degree=Pos	_	_	_	_
6	phorbol	phorbol	NOUN	NN	Number=Sing	_	_	_	_
7	esters	ester	NOUN	NNS	Number=Plur	_	_	_	_
8	reveal	reveal	ADJ	JJ	Degree=Pos	_	_	_	_
9	that	that	SCONJ	IN	_	_	_	_	_
10	differentiation	differentiation	NOUN	NN	Number=Sing	_	_	_	_
11	becomes	become	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
12	irreversible	irreversible	ADJ	JJ	Degree=Pos	_	_	_	_
13	soon	soon	ADV	RB	Degree=Pos	_	_	_	_
14	after	after	SCONJ	IN	_	_	_	_	_
15	AP	ap	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
16	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
17	1	1	NUM	CD	NumType=Card	_	_	_	_
18	appears	appear	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	SpaceAfter=No
19	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1019
# text = This tight correlation between c-jun expression, the generation of AP-1 activity, and differentiation suggests a critical role for this gene and transcriptional complex during this process.
1	This	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
2	tight	tight	ADJ	JJ	Degree=Pos	_	_	_	_
3	correlation	correlation	NOUN	NN	Number=Sing	_	_	_	_
4	between	between	ADP	IN	_	_	_	_	_
5	c-	c-	SYM	NFP	_	_	_	_	SpaceAfter=No
6	jun	jun	NOUN	NN	Number=Sing	_	_	_	_
7	expression	expression	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
8	,	,	PUNCT	,	_	_	_	_	_
9	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
10	generation	generation	NOUN	NN	Number=Sing	_	_	_	_
11	of	of	ADP	IN	_	_	_	_	_
12	AP	Ap	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
13	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
14	1	1	NUM	CD	NumType=Card	_	_	_	_
15	activity	activity	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
16	,	,	PUNCT	,	_	_	_	_	_
17	and	and	CCONJ	CC	_	_	_	_	_
18	differentiation	differentiation	NOUN	NN	Number=Sing	_	_	_	_
19	suggests	suggest	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
20	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
21	critical	critical	ADJ	JJ	Degree=Pos	_	_	_	_
22	role	role	NOUN	NN	Number=Sing	_	_	_	_
23	for	for	ADP	IN	_	_	_	_	_
24	this	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
25	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
26	and	and	CCONJ	CC	_	_	_	_	_
27	transcriptional	transcriptional	ADJ	JJ	Degree=Pos	_	_	_	_
28	complex	complex	NOUN	NN	Number=Sing	_	_	_	_
29	during	during	ADP	IN	_	_	_	_	_
30	this	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
31	process	process	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
32	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 1020
# text = Document 003002364 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	003002364	003002364	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 1021
# text = p21ras initiates Rac-1 but not phosphatidyl inositol 3 kinase/PKB, mediated signaling pathways in T lymphocytes.
1	p21ras	p21ras	NOUN	NNS	Number=Plur	_	_	_	_
2	initiates	initiate	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
3	Rac	rac	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
4	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
5	1	1	NUM	CD	NumType=Card	_	_	_	_
6	but	but	CCONJ	CC	_	_	_	_	_
7	not	not	PART	RB	_	_	_	_	_
8	phosphatidyl	phosphatidyl	VERB	VB	VerbForm=Inf	_	_	_	_
9	inositol	inositol	INTJ	UH	_	_	_	_	_
10	3	3	NUM	CD	NumType=Card	_	_	_	_
11	kinase	kinase	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
12	/	/	PUNCT	,	_	_	_	_	SpaceAfter=No
13	PKB	Pkb	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
14	,	,	PUNCT	,	_	_	_	_	_
15	mediated	mediate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
16	signaling	signaling	VERB	VBG	VerbForm=Ger	_	_	_	_
17	pathways	pathway	NOUN	NNS	Number=Plur	_	_	_	_
18	in	in	ADP	IN	_	_	_	_	_
19	T	t	PROPN	NNP	Number=Sing	_	_	_	_
20	lymphocytes	lymphocyte	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
21	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 1022
# text = p21ras is activated by the T cell antigen receptor (TCR) and then co-ordinates important signaling pathways for T lymphocyte activation.
1	p21ras	p21ras	NOUN	NNS	Number=Plur	_	_	_	_
2	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
3	activated	activate	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
4	by	by	ADP	IN	_	_	_	_	_
5	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
6	T	t	PROPN	NNP	Number=Sing	_	_	_	_
7	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
8	antigen	antigen	NUM	CD	NumType=Card	_	_	_	_
9	receptor	receptor	NOUN	NN	Number=Sing	_	_	_	_
10	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
11	TCR	TCR	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
12	)	)	PUNCT	-RRB-	_	_	_	_	_
13	and	and	CCONJ	CC	_	_	_	_	_
14	then	then	ADV	RB	PronType=Dem	_	_	_	_
15	co-ordinates	co-ordinate	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
16	important	important	ADJ	JJ	Degree=Pos	_	_	_	_
17	signaling	signaling	NOUN	NN	Number=Sing	_	_	_	_
18	pathways	pathway	NOUN	NNS	Number=Plur	_	_	_	_
19	for	for	ADP	IN	_	_	_	_	_
20	T	t	PROPN	NNP	Number=Sing	_	_	_	_
21	lymphocyte	lymphocyte	NOUN	NN	Number=Sing	_	_	_	_
22	activation	activation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
23	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1023
# text = Effector pathways for this guanine nucleotide binding protein in T cells are mediated by the serine/threonine kinase Raf-1 and the Ras-related GTPase Rac-1.
1	Effector	Effector	NOUN	NN	Number=Sing	_	_	_	_
2	pathways	pathway	NOUN	NNS	Number=Plur	_	_	_	_
3	for	for	ADP	IN	_	_	_	_	_
4	this	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
5	guanine	guanine	NOUN	NN	Number=Sing	_	_	_	_
6	nucleotide	nucleotide	NOUN	NN	Number=Sing	_	_	_	_
7	binding	bind	VERB	VBG	VerbForm=Ger	_	_	_	_
8	protein	protein	NOUN	NN	Number=Sing	_	_	_	_
9	in	in	ADP	IN	_	_	_	_	_
10	T	t	PROPN	NNP	Number=Sing	_	_	_	_
11	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
12	are	be	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
13	mediated	mediate	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
14	by	by	ADP	IN	_	_	_	_	_
15	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
16	serine	serine	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
17	/	/	PUNCT	,	_	_	_	_	SpaceAfter=No
18	threonine	threonine	NUM	CD	NumType=Card	_	_	_	_
19	kinase	kinase	NOUN	NN	Number=Sing	_	_	_	_
20	Raf	Raf	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
21	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
22	1	1	NUM	CD	NumType=Card	_	_	_	_
23	and	and	CCONJ	CC	_	_	_	_	_
24	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
25	Ras-	ras-	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
26	related	relate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
27	GTPase	GTPase	PROPN	NNP	Number=Sing	_	_	_	_
28	Rac	rac	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
29	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
30	1	1	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
31	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1024
# text = In fibroblasts, an important effector for the Ras oncogene is Phosphatidylinositol 3-kinase (PtdIns 3-kinase).
1	In	in	ADP	IN	_	_	_	_	_
2	fibroblasts	fibroblast	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
3	,	,	PUNCT	,	_	_	_	_	_
4	an	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
5	important	important	ADJ	JJ	Degree=Pos	_	_	_	_
6	effector	effector	NOUN	NN	Number=Sing	_	_	_	_
7	for	for	ADP	IN	_	_	_	_	_
8	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
9	Ras	Ras	PROPN	NNP	Number=Sing	_	_	_	_
10	oncogene	oncogene	PROPN	NNP	Number=Sing	_	_	_	_
11	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
12	Phosphatidylinositol	Phosphatidylinositol	PROPN	NNP	Number=Sing	_	_	_	_
13	3	3	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
14	-	-	PUNCT	:	_	_	_	_	SpaceAfter=No
15	kinase	kinase	NOUN	NN	Number=Sing	_	_	_	_
16	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
17	PtdIns	PtdIn	NOUN	NNS	Number=Plur	_	_	_	_
18	3	3	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
19	-	-	PUNCT	:	_	_	_	_	SpaceAfter=No
20	kinase	kinase	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
21	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
22	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1025
# text = Activation of this lipid kinase is able to induce critical Rac-1 signaling pathways and can couple p21ras to cell survival mechanisms via the serine/threonine kinase Akt/PKB.
1	Activation	Activation	NOUN	NN	Number=Sing	_	_	_	_
2	of	of	ADP	IN	_	_	_	_	_
3	this	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
4	lipid	lipid	NOUN	NN	Number=Sing	_	_	_	_
5	kinase	kinase	NOUN	NN	Number=Sing	_	_	_	_
6	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
7	able	able	ADJ	JJ	Degree=Pos	_	_	_	_
8	to	to	PART	TO	_	_	_	_	_
9	induce	induce	VERB	VB	VerbForm=Inf	_	_	_	_
10	critical	critical	ADJ	JJ	Degree=Pos	_	_	_	_
11	Rac	rac	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
12	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
13	1	1	NUM	CD	NumType=Card	_	_	_	_
14	signaling	signaling	NOUN	NN	Number=Sing	_	_	_	_
15	pathways	pathway	NOUN	NNS	Number=Plur	_	_	_	_
16	and	and	CCONJ	CC	_	_	_	_	_
17	can	can	AUX	MD	VerbForm=Fin	_	_	_	_
18	couple	couple	VERB	VB	VerbForm=Inf	_	_	_	_
19	p21ras	p21ra	NOUN	NNS	Number=Plur	_	_	_	_
20	to	to	PART	TO	_	_	_	_	_
21	cell	cell	VERB	VB	VerbForm=Inf	_	_	_	_
22	survival	survival	NOUN	NN	Number=Sing	_	_	_	_
23	mechanisms	mechanism	NOUN	NNS	Number=Plur	_	_	_	_
24	via	via	ADP	IN	_	_	_	_	_
25	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
26	serine	serine	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
27	/	/	PUNCT	,	_	_	_	_	SpaceAfter=No
28	threonine	threonine	NUM	CD	NumType=Card	_	_	_	_
29	kinase	kinase	NOUN	NN	Number=Sing	_	_	_	_
30	Akt	Akt	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
31	/	/	PUNCT	,	_	_	_	_	SpaceAfter=No
32	PKB	PKB	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
33	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1026
# text = The role of PtdIns 3-kinase in Ras signaling in T cells has not been explored.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	role	role	NOUN	NN	Number=Sing	_	_	_	_
3	of	of	ADP	IN	_	_	_	_	_
4	PtdIns	PtdIns	PROPN	NNPS	Number=Plur	_	_	_	_
5	3	3	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
6	-	-	PUNCT	:	_	_	_	_	SpaceAfter=No
7	kinase	kinase	NOUN	NN	Number=Sing	_	_	_	_
8	in	in	ADP	IN	_	_	_	_	_
9	Ras	Ras	PROPN	NNP	Number=Sing	_	_	_	_
10	signaling	signal	VERB	VBG	VerbForm=Ger	_	_	_	_
11	in	in	ADP	IN	_	_	_	_	_
12	T	T	PROPN	NNP	Number=Sing	_	_	_	_
13	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
14	has	have	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
15	not	not	PART	RB	_	_	_	_	_
16	been	be	AUX	VBN	Tense=Past|VerbForm=Part	_	_	_	_
17	explored	explore	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	SpaceAfter=No
18	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1027
# text = In the present study, we examined the ability of PtdIns 3-kinase to initiate the Rac-1 signaling pathways important for T cell activation.
1	In	in	ADP	IN	_	_	_	_	_
2	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
3	present	present	ADJ	JJ	Degree=Pos	_	_	_	_
4	study	study	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
5	,	,	PUNCT	,	_	_	_	_	_
6	we	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
7	examined	examin	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
8	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
9	ability	ability	NOUN	NN	Number=Sing	_	_	_	_
10	of	of	ADP	IN	_	_	_	_	_
11	PtdIns	PtdIns	PROPN	NNPS	Number=Plur	_	_	_	_
12	3	3	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
13	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
14	kinase	kinase	NOUN	NN	Number=Sing	_	_	_	_
15	to	to	PART	TO	_	_	_	_	_
16	initiate	initiate	VERB	VB	VerbForm=Inf	_	_	_	_
17	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
18	Rac	rac	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
19	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
20	1	1	NUM	CD	NumType=Card	_	_	_	_
21	signaling	signaling	NOUN	NN	Number=Sing	_	_	_	_
22	pathways	pathway	NOUN	NNS	Number=Plur	_	_	_	_
23	important	important	ADJ	JJ	Degree=Pos	_	_	_	_
24	for	for	ADP	IN	_	_	_	_	_
25	T	t	PROPN	NNP	Number=Sing	_	_	_	_
26	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
27	activation	activation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
28	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1028
# text = We also examined the possibility that Akt/PKB is regulated by Ras signaling pathways in T lymphocytes.
1	We	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
2	also	also	ADV	RB	_	_	_	_	_
3	examined	examin	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
4	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
5	possibility	possibility	NOUN	NN	Number=Sing	_	_	_	_
6	that	that	PRON	WDT	PronType=Rel	_	_	_	_
7	Akt	Akt	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
8	/	/	PUNCT	,	_	_	_	_	SpaceAfter=No
9	PKB	PKB	PROPN	NNP	Number=Sing	_	_	_	_
10	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
11	regulated	regulate	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
12	by	by	ADP	IN	_	_	_	_	_
13	Ras	Ras	SCONJ	IN	_	_	_	_	_
14	signaling	signaling	VERB	VBG	VerbForm=Ger	_	_	_	_
15	pathways	pathways	NOUN	NNS	Number=Plur	_	_	_	_
16	in	in	ADP	IN	_	_	_	_	_
17	T	t	PROPN	NNP	Number=Sing	_	_	_	_
18	lymphocytes	lymphocyte	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
19	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1029
# text = The results show that Ras can initiate a Rac-1 mediated pathway that regulates the transcriptional function of AP-1 complexes.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	results	result	NOUN	NNS	Number=Plur	_	_	_	_
3	show	show	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
4	that	that	SCONJ	IN	_	_	_	_	_
5	Ras	Ras	PROPN	NNP	Number=Sing	_	_	_	_
6	can	can	AUX	MD	VerbForm=Fin	_	_	_	_
7	initiate	initiate	VERB	VB	VerbForm=Inf	_	_	_	_
8	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
9	Rac	rac	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
10	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
11	1	1	X	LS	_	_	_	_	_
12	mediated	mediate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
13	pathway	pathway	NOUN	NN	Number=Sing	_	_	_	_
14	that	that	PRON	WDT	PronType=Rel	_	_	_	_
15	regulates	regulate	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
16	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
17	transcriptional	transcriptional	ADJ	JJ	Degree=Pos	_	_	_	_
18	function	function	NOUN	NN	Number=Sing	_	_	_	_
19	of	of	ADP	IN	_	_	_	_	_
20	AP	ap	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
21	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
22	1	1	NUM	CD	NumType=Card	_	_	_	_
23	complexes	complex	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
24	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1030
# text = PtdIns 3-kinase signals cannot mimic p21ras and induce the Rac mediated responses of AP-1 transcriptional activation.
1	PtdIns	PtdIn	NOUN	NNS	Number=Plur	_	_	_	_
2	3	3	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
3	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
4	kinase	kinase	NOUN	NN	Number=Sing	_	_	_	_
5	signals	signal	NOUN	NNS	Number=Plur	_	_	_	_
6	can	can	AUX	MD	VerbForm=Fin	_	_	_	SpaceAfter=No
7	not	not	PART	RB	_	_	_	_	_
8	mimic	mimic	ADJ	JJ	Degree=Pos	_	_	_	_
9	p21ras	p21ra	NOUN	NNS	Number=Plur	_	_	_	_
10	and	and	CCONJ	CC	_	_	_	_	_
11	induce	induce	VERB	VB	VerbForm=Inf	_	_	_	_
12	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
13	Rac	Rac	PROPN	NNP	Number=Sing	_	_	_	_
14	mediated	mediate	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
15	responses	response	NOUN	NNS	Number=Plur	_	_	_	_
16	of	of	ADP	IN	_	_	_	_	_
17	AP	ap	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
18	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
19	1	1	NUM	CD	NumType=Card	_	_	_	_
20	transcriptional	transcriptional	ADJ	JJ	Degree=Pos	_	_	_	_
21	activation	activation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
22	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1031
# text = Moreover, neither TCR or Ras activation of AP-1 is dependent on PtdIns 3-kinase.
1	Moreover	moreover	ADV	RB	_	_	_	_	SpaceAfter=No
2	,	,	PUNCT	,	_	_	_	_	_
3	neither	neither	CCONJ	CC	_	_	_	_	_
4	TCR	TCR	PROPN	NNP	Number=Sing	_	_	_	_
5	or	or	CCONJ	CC	_	_	_	_	_
6	Ras	Ras	PROPN	NNP	Number=Sing	_	_	_	_
7	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
8	of	of	ADP	IN	_	_	_	_	_
9	AP	ap	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
10	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
11	1	1	NUM	CD	NumType=Card	_	_	_	_
12	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
13	dependent	dependent	ADJ	JJ	Degree=Pos	_	_	_	_
14	on	on	ADP	IN	_	_	_	_	_
15	PtdIns	PtdIns	PROPN	NNPS	Number=Plur	_	_	_	_
16	3	3	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
17	-kinase	-kinase	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
18	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1032
# text = PKB is activated in response to triggering of the T cell antigen receptor; PtdIns 3-kinase activity is both required and sufficient for this TCR response.
1	PKB	PKB	PROPN	NNP	Number=Sing	_	_	_	_
2	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
3	activated	activate	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
4	in	in	ADP	IN	_	_	_	_	_
5	response	response	NOUN	NN	Number=Sing	_	_	_	_
6	to	to	SCONJ	IN	_	_	_	_	_
7	triggering	triggere	VERB	VBG	VerbForm=Ger	_	_	_	_
8	of	of	ADP	IN	_	_	_	_	_
9	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
10	T	T	PROPN	NNP	Number=Sing	_	_	_	_
11	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
12	antigen	antigen	NUM	CD	NumType=Card	_	_	_	_
13	receptor	receptor	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
14	;	;	PUNCT	,	_	_	_	_	_
15	PtdIns	PtdIns	NOUN	NNS	Number=Plur	_	_	_	_
16	3	3	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
17	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
18	kinase	kinase	NOUN	NN	Number=Sing	_	_	_	_
19	activity	activity	NOUN	NN	Number=Sing	_	_	_	_
20	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
21	both	both	ADV	RB	_	_	_	_	_
22	required	required	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
23	and	and	CCONJ	CC	_	_	_	_	_
24	sufficient	sufficient	ADJ	JJ	Degree=Pos	_	_	_	_
25	for	for	ADP	IN	_	_	_	_	_
26	this	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
27	TCR	Tcr	NOUN	NN	Number=Sing	_	_	_	_
28	response	response	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
29	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1033
# text = In contrast, p21ras signals are unable to induce Akt/PKB activity in T cell nor is Ras function required for Akt/PKB activation in response to the TCR.
1	In	in	ADP	IN	_	_	_	_	_
2	contrast	contrast	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
3	,	,	PUNCT	,	_	_	_	_	_
4	p21ras	p21ras	NOUN	NN	Number=Sing	_	_	_	_
5	signals	signal	NOUN	NNS	Number=Plur	_	_	_	_
6	are	be	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
7	unable	unable	ADJ	JJ	Degree=Pos	_	_	_	_
8	to	to	PART	TO	_	_	_	_	_
9	induce	induce	VERB	VB	VerbForm=Inf	_	_	_	_
10	Akt	Akt	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
11	/	/	PUNCT	,	_	_	_	_	SpaceAfter=No
12	PKB	PKB	PROPN	NNP	Number=Sing	_	_	_	_
13	activity	activity	NOUN	NN	Number=Sing	_	_	_	_
14	in	in	ADP	IN	_	_	_	_	_
15	T	t	PROPN	NNP	Number=Sing	_	_	_	_
16	cell	cell	PROPN	NNP	Number=Sing	_	_	_	_
17	nor	nor	CCONJ	CC	_	_	_	_	_
18	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
19	Ras	Ras	PROPN	NNP	Number=Sing	_	_	_	_
20	function	function	NOUN	NN	Number=Sing	_	_	_	_
21	required	require	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
22	for	for	ADP	IN	_	_	_	_	_
23	Akt	Akt	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
24	/	/	PUNCT	,	_	_	_	_	SpaceAfter=No
25	PKB	PKB	PROPN	NNP	Number=Sing	_	_	_	_
26	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
27	in	in	ADP	IN	_	_	_	_	_
28	response	response	NOUN	NN	Number=Sing	_	_	_	_
29	to	to	ADP	IN	_	_	_	_	_
30	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
31	TCR	Tcr	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
32	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1034
# text = The present data thus highlight that PtdIns 3-kinase and Akt/PKB are not universal Ras effector molecules.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	present	present	ADJ	JJ	Degree=Pos	_	_	_	_
3	data	data	NOUN	NN	Number=Sing	_	_	_	_
4	thus	thus	ADV	RB	_	_	_	_	_
5	highlight	highlight	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
6	that	that	SCONJ	IN	_	_	_	_	_
7	PtdIns	PtdIns	PROPN	NNPS	Number=Plur	_	_	_	_
8	3	3	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
9	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
10	kinase	kinase	NOUN	NN	Number=Sing	_	_	_	_
11	and	and	CCONJ	CC	_	_	_	_	_
12	Akt	Akt	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
13	/	/	PUNCT	,	_	_	_	_	SpaceAfter=No
14	PKB	Pkb	NOUN	NN	Number=Sing	_	_	_	_
15	are	be	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
16	not	not	PART	RB	_	_	_	_	_
17	universal	universal	ADJ	JJ	Degree=Pos	_	_	_	_
18	Ras	Ras	PROPN	NNP	Number=Sing	_	_	_	_
19	effector	effector	NOUN	NN	Number=Sing	_	_	_	_
20	molecules	molecule	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
21	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1035
# text = Ras can initiate Rac-1 regulated signaling pathways in the context of T cell antigen receptor function independently of PtdIns 3-kinase activity.
1	Ras	Ra	NOUN	NNS	Number=Plur	_	_	_	_
2	can	can	AUX	MD	VerbForm=Fin	_	_	_	_
3	initiate	initiate	VERB	VB	VerbForm=Inf	_	_	_	_
4	Rac	rac	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
5	-	-	SYM	SYM	_	_	_	_	SpaceAfter=No
6	1	1	NUM	CD	NumType=Card	_	_	_	_
7	regulated	regulate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
8	signaling	signaling	VERB	VBG	VerbForm=Ger	_	_	_	_
9	pathways	pathway	NOUN	NNS	Number=Plur	_	_	_	_
10	in	in	ADP	IN	_	_	_	_	_
11	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
12	context	context	NOUN	NN	Number=Sing	_	_	_	_
13	of	of	ADP	IN	_	_	_	_	_
14	T	t	PROPN	NNP	Number=Sing	_	_	_	_
15	cell	cell	PROPN	NNP	Number=Sing	_	_	_	_
16	antigen	antigen	ADJ	JJ	Degree=Pos	_	_	_	_
17	receptor	receptor	NOUN	NN	Number=Sing	_	_	_	_
18	function	function	NOUN	NN	Number=Sing	_	_	_	_
19	independently	independently	ADV	RB	_	_	_	_	_
20	of	of	ADP	IN	_	_	_	_	_
21	PtdIns	PtdIns	PROPN	NNPS	Number=Plur	_	_	_	_
22	3	3	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
23	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
24	kinase	kinase	NOUN	NN	Number=Sing	_	_	_	_
25	activity	activity	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
26	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 1036
# text = Document 003002368 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	003002368	003002368	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 1037
# text = Calcineurin activates transcription from the GM-CSF promoter in synergy with either protein kinase C or NF-kappa B/AP-1 in T cells.
1	Calcineurin	Calcineurin	PROPN	NNP	Number=Sing	_	_	_	_
2	activates	activate	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
3	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
4	from	from	ADP	IN	_	_	_	_	_
5	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
6	GM	GM	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
7	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
8	CSF	CSF	PROPN	NNP	Number=Sing	_	_	_	_
9	promoter	promoter	NOUN	NN	Number=Sing	_	_	_	_
10	in	in	ADP	IN	_	_	_	_	_
11	synergy	synergy	NOUN	NN	Number=Sing	_	_	_	_
12	with	with	ADP	IN	_	_	_	_	_
13	either	either	CCONJ	CC	_	_	_	_	_
14	protein	protein	NOUN	NN	Number=Sing	_	_	_	_
15	kinase	kinase	NOUN	NN	Number=Sing	_	_	_	_
16	C	c	PROPN	NNP	Number=Sing	_	_	_	_
17	or	or	CCONJ	CC	_	_	_	_	_
18	NF	Nf	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
19	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
20	kappa	kappa	PROPN	NNP	Number=Sing	_	_	_	_
21	B	b	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
22	/AP	/ap	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
23	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
24	1	1	NUM	CD	NumType=Card	_	_	_	_
25	in	in	ADP	IN	_	_	_	_	_
26	T	t	PROPN	NNP	Number=Sing	_	_	_	_
27	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
28	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 1038
# text = Two cis-acting elements GM-kappa B/GC-box and CLE0, of the granulocyte-macrophage colony-stimulating factor (GM-CSF) gene are required for maximal induction in Jurkat T cells by costimulation with phorbol-12-myristate acetate (PMA) and Ca2+ ionophore (A23187).
1	Two	two	NUM	CD	NumType=Card	_	_	_	_
2	cis	cis	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
3	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
4	acting	acte	VERB	VBG	VerbForm=Ger	_	_	_	_
5	elements	element	NOUN	NNS	Number=Plur	_	_	_	_
6	GM	GM	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
7	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
8	kappa	kappa	PROPN	NNP	Number=Sing	_	_	_	_
9	B/GC	B/gc	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
10	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
11	box	box	NOUN	NN	Number=Sing	_	_	_	_
12	and	and	CCONJ	CC	_	_	_	_	_
13	CLE0	CLE0	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
14	,	,	PUNCT	,	_	_	_	_	_
15	of	of	ADP	IN	_	_	_	_	_
16	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
17	granulocyte	granulocyte	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
18	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
19	macrophage	macrophage	NOUN	NN	Number=Sing	_	_	_	_
20	colony	colony	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
21	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
22	stimulating	stimulating	VERB	VBG	VerbForm=Ger	_	_	_	_
23	factor	factor	NOUN	NN	Number=Sing	_	_	_	_
24	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
25	GM	GM	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
26	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
27	CSF	CSF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
28	)	)	PUNCT	-RRB-	_	_	_	_	_
29	gene	gene	PRON	NN	Number=Sing	_	_	_	_
30	are	be	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
31	required	require	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
32	for	for	ADP	IN	_	_	_	_	_
33	maximal	maximal	ADJ	JJ	Degree=Pos	_	_	_	_
34	induction	induction	NOUN	NN	Number=Sing	_	_	_	_
35	in	in	ADP	IN	_	_	_	_	_
36	Jurkat	Jurkat	PROPN	NNP	Number=Sing	_	_	_	_
37	T	t	PROPN	NNP	Number=Sing	_	_	_	_
38	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
39	by	by	ADP	IN	_	_	_	_	_
40	costimulation	costimulation	NOUN	NN	Number=Sing	_	_	_	_
41	with	with	ADP	IN	_	_	_	_	_
42	phorbol	phorbol	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
43	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
44	12	12	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
45	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
46	myristate	myristate	NOUN	NN	Number=Sing	_	_	_	_
47	acetate	acetate	NOUN	NN	Number=Sing	_	_	_	_
48	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
49	PMA	PMA	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
50	)	)	PUNCT	-RRB-	_	_	_	_	_
51	and	and	CCONJ	CC	_	_	_	_	_
52	Ca2	Ca2	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
53	+	+	SYM	SYM	_	_	_	_	_
54	ionophore	ionophore	NOUN	NN	Number=Sing	_	_	_	_
55	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
56	A23187	A23187	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
57	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
58	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1039
# text = The GM-kappa B sequence is recognized by NF-kappa B, which is mainly induced by PMA.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	GM	gm	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
3	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
4	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_
5	B	b	NOUN	NN	Number=Sing	_	_	_	_
6	sequence	sequence	NOUN	NN	Number=Sing	_	_	_	_
7	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
8	recognized	recognize	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
9	by	by	ADP	IN	_	_	_	_	_
10	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
11	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
12	kappa	kappa	PROPN	NNP	Number=Sing	_	_	_	_
13	B	b	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
14	,	,	PUNCT	,	_	_	_	_	_
15	which	which	PRON	WDT	PronType=Rel	_	_	_	_
16	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
17	mainly	mainly	ADV	RB	_	_	_	_	_
18	induced	induce	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
19	by	by	ADP	IN	_	_	_	_	_
20	PMA	PMA	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
21	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1040
# text = The CLE0 sequence interacts with factors, related to a PMA-induced AP-1 and a PMA/A23187-induced NF-AT.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	CLE0	CLE0	NUM	CD	NumType=Card	_	_	_	_
3	sequence	sequence	NOUN	NN	Number=Sing	_	_	_	_
4	interacts	interact	NOUN	NNS	Number=Plur	_	_	_	_
5	with	with	ADP	IN	_	_	_	_	_
6	factors	factor	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
7	,	,	PUNCT	,	_	_	_	_	_
8	related	related	ADJ	JJ	Degree=Pos	_	_	_	_
9	to	to	ADP	IN	_	_	_	_	_
10	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
11	PMA	PMA	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
12	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
13	induced	induce	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
14	AP	ap	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
15	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
16	1	1	NUM	CD	NumType=Card	_	_	_	_
17	and	and	CCONJ	CC	_	_	_	_	_
18	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
19	PMA/A23187	PMA/A23187	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
20	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
21	induced	induce	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
22	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
23	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
24	AT	AT	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
25	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1041
# text = We examined whether signal transducing components in T cells can activate transcription of the GM-CSF gene.
1	We	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
2	examined	examin	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
3	whether	whether	SCONJ	IN	_	_	_	_	_
4	signal	signal	NOUN	NN	Number=Sing	_	_	_	_
5	transducing	transduce	VERB	VBG	VerbForm=Ger	_	_	_	_
6	components	component	NOUN	NNS	Number=Plur	_	_	_	_
7	in	in	ADP	IN	_	_	_	_	_
8	T	t	PROPN	NNP	Number=Sing	_	_	_	_
9	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
10	can	can	AUX	MD	VerbForm=Fin	_	_	_	_
11	activate	activate	VERB	VB	VerbForm=Inf	_	_	_	_
12	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
13	of	of	ADP	IN	_	_	_	_	_
14	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
15	GM	GM	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
16	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
17	CSF	CSF	PROPN	NNP	Number=Sing	_	_	_	_
18	gene	gene	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
19	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1042
# text = Cotransfection of NF-kappa B (p50/p65)- or AP-1 (c-Jun/c-Fos)- expression vectors into Jurkat cells with a luciferase reporter containing the GM-CSF promoter did not stimulate transcription from the GM-CSF promoter.
1	Cotransfection	Cotransfection	NOUN	NN	Number=Sing	_	_	_	_
2	of	of	ADP	IN	_	_	_	_	_
3	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
4	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
5	kappa	kappa	PROPN	NNP	Number=Sing	_	_	_	_
6	B	b	PROPN	NNP	Number=Sing	_	_	_	_
7	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
8	p50/	p50ith	ADP	IN	Abbr=Yes	_	_	_	SpaceAfter=No
9	p65	p65	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
10	)-	)-	PUNCT	.	_	_	_	_	_
11	or	or	CCONJ	CC	_	_	_	_	_
12	AP	ap	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
13	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
14	1	1	NUM	CD	NumType=Card	_	_	_	_
15	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
16	c-	c-	SYM	NFP	_	_	_	_	SpaceAfter=No
17	Jun/c	Jun/c	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
18	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
19	Fos	Fos	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
20	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
21	-	-	PUNCT	:	_	_	_	_	_
22	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
23	vectors	vector	NOUN	NNS	Number=Plur	_	_	_	_
24	into	into	ADP	IN	_	_	_	_	_
25	Jurkat	Jurkat	PROPN	NNP	Number=Sing	_	_	_	_
26	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
27	with	with	ADP	IN	_	_	_	_	_
28	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
29	luciferase	luciferase	NOUN	NN	Number=Sing	_	_	_	_
30	reporter	reporter	NOUN	NN	Number=Sing	_	_	_	_
31	containing	contain	VERB	VBG	VerbForm=Ger	_	_	_	_
32	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
33	GM	GM	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
34	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
35	CSF	CSF	PROPN	NNP	Number=Sing	_	_	_	_
36	promoter	promoter	NOUN	NN	Number=Sing	_	_	_	_
37	did	do	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
38	not	not	PART	RB	_	_	_	_	_
39	stimulate	stimulate	VERB	VB	VerbForm=Inf	_	_	_	_
40	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
41	from	from	ADP	IN	_	_	_	_	_
42	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
43	GM	GM	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
44	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
45	CSF	CSF	PROPN	NNP	Number=Sing	_	_	_	_
46	promoter	promoter	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
47	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1043
# text = In contrast, cotransfection with a combination of NF-kappa B and AP-1 significantly augmented transcription from the GM-CSF promoter containing the GM-kappa B/GC-box and the CLE0 (AP-1/NF-AT).
1	In	in	ADP	IN	_	_	_	_	_
2	contrast	contrast	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
3	,	,	PUNCT	,	_	_	_	_	_
4	cotransfection	cotransfection	NOUN	NN	Number=Sing	_	_	_	_
5	with	with	ADP	IN	_	_	_	_	_
6	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
7	combination	combination	NOUN	NN	Number=Sing	_	_	_	_
8	of	of	ADP	IN	_	_	_	_	_
9	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
10	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
11	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_
12	B	b	NOUN	NN	Number=Sing	_	_	_	_
13	and	and	CCONJ	CC	_	_	_	_	_
14	AP	ap	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
15	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
16	1	1	NUM	CD	NumType=Card	_	_	_	_
17	significantly	significantly	ADV	RB	_	_	_	_	_
18	augmented	augment	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
19	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
20	from	from	ADP	IN	_	_	_	_	_
21	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
22	GM	GM	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
23	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
24	CSF	CSF	PROPN	NNP	Number=Sing	_	_	_	_
25	promoter	promoter	NOUN	NN	Number=Sing	_	_	_	_
26	containing	contain	VERB	VBG	VerbForm=Ger	_	_	_	_
27	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
28	GM	GM	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
29	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
30	kappa	kappa	PROPN	NNP	Number=Sing	_	_	_	_
31	B/GC	B/gc	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
32	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
33	box	box	NOUN	NN	Number=Sing	_	_	_	_
34	and	and	CCONJ	CC	_	_	_	_	_
35	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
36	CLE0	CLE0	NOUN	NN	Number=Sing	_	_	_	_
37	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
38	AP	ap	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
39	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
40	1/NF	1/nf	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
41	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
42	AT	At	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
43	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
44	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1044
# text = Expression of a constitutively active calcineurin (CN), a Ca2+/calmodulin-dependent protein phosphatase, potentiated by two fold the transcriptional activation by NF-kappa B/AP-1.
1	Expression	expression	NOUN	NN	Number=Sing	_	_	_	_
2	of	of	ADP	IN	_	_	_	_	_
3	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
4	constitutively	constitutively	ADV	RB	_	_	_	_	_
5	active	active	ADJ	JJ	Degree=Pos	_	_	_	_
6	calcineurin	calcineurin	NOUN	NN	Number=Sing	_	_	_	_
7	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
8	CN	CN	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
9	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
10	,	,	PUNCT	,	_	_	_	_	_
11	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
12	Ca2+/calmodulin	Ca2+/calmodulin	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
13	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
14	dependent	dependent	ADJ	JJ	Degree=Pos	_	_	_	_
15	protein	protein	NOUN	NN	Number=Sing	_	_	_	_
16	phosphatase	phosphatase	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
17	,	,	PUNCT	,	_	_	_	_	_
18	potentiated	potentiate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
19	by	by	ADP	IN	_	_	_	_	_
20	two	two	NUM	CD	NumType=Card	_	_	_	_
21	fold	fold	NOUN	NN	Number=Sing	_	_	_	_
22	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
23	transcriptional	transcriptional	ADJ	JJ	Degree=Pos	_	_	_	_
24	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
25	by	by	ADP	IN	_	_	_	_	_
26	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
27	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
28	kappa	kappa	PROPN	NNP	Number=Sing	_	_	_	_
29	B	b	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
30	/	/	PUNCT	,	_	_	_	_	SpaceAfter=No
31	AP	ap	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
32	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
33	1	1	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
34	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1045
# text = Both constitutively active forms of CN and protein kinase C (PKC) synergistically activated transcription from the GM-CSF promoter.
1	Both	both	DET	DT	_	_	_	_	_
2	constitutively	constitutively	ADV	RB	_	_	_	_	_
3	active	active	ADJ	JJ	Degree=Pos	_	_	_	_
4	forms	form	NOUN	NNS	Number=Plur	_	_	_	_
5	of	of	ADP	IN	_	_	_	_	_
6	CN	Cn	NOUN	NN	Number=Sing	_	_	_	_
7	and	and	CCONJ	CC	_	_	_	_	_
8	protein	protein	NOUN	NN	Number=Sing	_	_	_	_
9	kinase	kinase	NOUN	NN	Number=Sing	_	_	_	_
10	C	C	PROPN	NNP	Number=Sing	_	_	_	_
11	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
12	PKC	PKC	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
13	)	)	PUNCT	-RRB-	_	_	_	_	_
14	synergistically	synergistically	ADV	RB	_	_	_	_	_
15	activated	activate	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
16	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
17	from	from	ADP	IN	_	_	_	_	_
18	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
19	GM	GM	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
20	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
21	CSF	CSF	PROPN	NNP	Number=Sing	_	_	_	_
22	promoter	promoter	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
23	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1046
# text = These results suggest that cooperation among NF-kappa B-, AP-1- and NF-AT-binding sequences is required for induction of the GM-CSF gene through PKC- and Ca2+- signaling pathways downstream of T cell activation.
1	These	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
2	results	result	NOUN	NNS	Number=Plur	_	_	_	_
3	suggest	suggest	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
4	that	that	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
5	cooperation	cooperation	NOUN	NN	Number=Sing	_	_	_	_
6	among	among	ADP	IN	_	_	_	_	_
7	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
8	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
9	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_
10	B	b	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
11	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
12	,	,	PUNCT	,	_	_	_	_	_
13	AP	ap	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
14	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
15	1	1	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
16	-	-	PUNCT	HYPH	_	_	_	_	_
17	and	and	CCONJ	CC	_	_	_	_	_
18	NF	Nf	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
19	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
20	AT	at	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
21	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
22	binding	binding	VERB	VBG	VerbForm=Ger	_	_	_	_
23	sequences	sequence	NOUN	NNS	Number=Plur	_	_	_	_
24	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
25	required	require	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
26	for	for	ADP	IN	_	_	_	_	_
27	induction	induction	NOUN	NN	Number=Sing	_	_	_	_
28	of	of	ADP	IN	_	_	_	_	_
29	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
30	GM	GM	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
31	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
32	CSF	CSF	PROPN	NNP	Number=Sing	_	_	_	_
33	gene	gene	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
34	through	through	ADP	IN	_	_	_	_	_
35	PKC	PKC	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
36	-	-	PUNCT	,	_	_	_	_	_
37	and	and	CCONJ	CC	_	_	_	_	_
38	Ca2	Ca2	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
39	+-	+-	PUNCT	,	_	_	_	_	_
40	signaling	signal	VERB	VBG	VerbForm=Ger	_	_	_	_
41	pathways	pathways	NOUN	NNS	Number=Plur	_	_	_	_
42	downstream	downstream	NOUN	NN	Number=Sing	_	_	_	_
43	of	of	ADP	IN	_	_	_	_	_
44	T	t	PROPN	NNP	Number=Sing	_	_	_	_
45	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
46	activation	activation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
47	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 1047
# text = Document 003002369 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	003002369	003002369	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 1048
# text = Nasal NK- and T-cell lymphomas share the same type of Epstein-Barr virus latency as nasopharyngeal carcinoma and Hodgkin's disease.
1	Nasal	Nasal	PROPN	NNP	Number=Sing	_	_	_	_
2	NK	NK	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
3	-	-	PUNCT	,	_	_	_	_	_
4	and	and	CCONJ	CC	_	_	_	_	_
5	T-	T-	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
6	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
7	lymphomas	lymphoma	NOUN	NNS	Number=Plur	_	_	_	_
8	share	share	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
9	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
10	same	same	ADJ	JJ	Degree=Pos	_	_	_	_
11	type	type	NOUN	NN	Number=Sing	_	_	_	_
12	of	of	ADP	IN	_	_	_	_	_
13	Epstein	Epstein	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
14	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
15	Barr	Barr	PROPN	NNP	Number=Sing	_	_	_	_
16	virus	virus	NOUN	NN	Number=Sing	_	_	_	_
17	latency	latency	NOUN	NN	Number=Sing	_	_	_	_
18	as	as	ADP	IN	_	_	_	_	_
19	nasopharyngeal	nasopharyngeal	ADJ	JJ	Degree=Pos	_	_	_	_
20	carcinoma	carcinoma	NOUN	NN	Number=Sing	_	_	_	_
21	and	and	CCONJ	CC	_	_	_	_	_
22	Hodgkin	Hodgkin	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
23	's	's	PART	POS	_	_	_	_	_
24	disease	disease	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
25	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 1049
# text = Nasal T/NK-cell lymphomas can be further separated into those of natural killer (NK) cell lineage or of T-cell lineage, with differences in cellular phenotype, T-cell receptor (TcR) gene rearrangement and TcR transcript expression.
1	Nasal	Nasal	PROPN	NNP	Number=Sing	_	_	_	_
2	T/NK	T/NK	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
3	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
4	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
5	lymphomas	lymphoma	NOUN	NNS	Number=Plur	_	_	_	_
6	can	can	AUX	MD	VerbForm=Fin	_	_	_	_
7	be	be	AUX	VB	VerbForm=Inf	_	_	_	_
8	further	further	ADV	RB	_	_	_	_	_
9	separated	separate	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
10	into	into	ADP	IN	_	_	_	_	_
11	those	those	PRON	DT	Number=Plur|PronType=Dem	_	_	_	_
12	of	of	ADP	IN	_	_	_	_	_
13	natural	natural	ADJ	JJ	Degree=Pos	_	_	_	_
14	killer	killer	NOUN	NN	Number=Sing	_	_	_	_
15	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
16	NK	NK	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
17	)	)	PUNCT	-RRB-	_	_	_	_	_
18	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
19	lineage	lineage	NOUN	NN	Number=Sing	_	_	_	_
20	or	or	CCONJ	CC	_	_	_	_	_
21	of	of	ADP	IN	_	_	_	_	_
22	T-	t-	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
23	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
24	lineage	lineage	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
25	,	,	PUNCT	,	_	_	_	_	_
26	with	with	ADP	IN	_	_	_	_	_
27	differences	difference	NOUN	NNS	Number=Plur	_	_	_	_
28	in	in	ADP	IN	_	_	_	_	_
29	cellular	cellular	ADJ	JJ	Degree=Pos	_	_	_	_
30	phenotype	phenotype	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
31	,	,	PUNCT	,	_	_	_	_	_
32	T-	T-	SYM	NFP	_	_	_	_	SpaceAfter=No
33	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
34	receptor	receptor	NOUN	NN	Number=Sing	_	_	_	_
35	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
36	TcR	TcR	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
37	)	)	PUNCT	-RRB-	_	_	_	_	_
38	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
39	rearrangement	rearrangement	NOUN	NN	Number=Sing	_	_	_	_
40	and	and	CCONJ	CC	_	_	_	_	_
41	TcR	Tcr	ADV	RBR	Degree=Cmp	_	_	_	_
42	transcript	transcript	ADJ	JJ	Degree=Pos	_	_	_	_
43	expression	expression	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
44	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1050
# text = Both NK- and T-cell subtypes are closely associated with Epstein-Barr virus (EBV).
1	Both	both	CCONJ	CC	_	_	_	_	_
2	NK	Nk	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
3	-	-	PUNCT	,	_	_	_	_	_
4	and	and	CCONJ	CC	_	_	_	_	_
5	T-	T-	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
6	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
7	subtypes	subtype	NOUN	NNS	Number=Plur	_	_	_	_
8	are	be	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
9	closely	closely	ADV	RB	_	_	_	_	_
10	associated	associate	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
11	with	with	ADP	IN	_	_	_	_	_
12	Epstein	Epstein	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
13	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
14	Barr	Barr	PROPN	NNP	Number=Sing	_	_	_	_
15	virus	virus	NOUN	NN	Number=Sing	_	_	_	_
16	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
17	EBV	EBV	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
18	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
19	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1051
# text = In this study, EBV gene expression was determined in 23 cases of nasal lymphoma (NL) by in situ hybridisation (ISH), reverse transcriptase-polymerase chain reaction (RT-PCR) and immunohistochemistry (IH).
1	In	in	ADP	IN	_	_	_	_	_
2	this	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
3	study	study	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
4	,	,	PUNCT	,	_	_	_	_	_
5	EBV	EBV	PROPN	NNP	Number=Sing	_	_	_	_
6	gene	gene	ADJ	JJ	Degree=Pos	_	_	_	_
7	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
8	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
9	determined	determine	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
10	in	in	ADP	IN	_	_	_	_	_
11	23	23	NUM	CD	NumType=Card	_	_	_	_
12	cases	case	NOUN	NNS	Number=Plur	_	_	_	_
13	of	of	ADP	IN	_	_	_	_	_
14	nasal	nasal	ADJ	JJ	Degree=Pos	_	_	_	_
15	lymphoma	lymphoma	NOUN	NN	Number=Sing	_	_	_	_
16	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
17	NL	NL	INTJ	UH	_	_	_	_	SpaceAfter=No
18	)	)	PUNCT	-RRB-	_	_	_	_	_
19	by	by	ADP	IN	_	_	_	_	_
20	in	in	ADP	IN	_	_	_	_	_
21	situ	situ	NOUN	NN	Number=Sing	_	_	_	_
22	hybridisation	hybridisation	NOUN	NN	Number=Sing	_	_	_	_
23	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
24	ISH	ISH	INTJ	UH	_	_	_	_	SpaceAfter=No
25	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
26	,	,	PUNCT	,	_	_	_	_	_
27	reverse	reverse	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
28	transcriptase	transcriptase	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
29	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
30	polymerase	polymerase	NOUN	NN	Number=Sing	_	_	_	_
31	chain	chain	NOUN	NN	Number=Sing	_	_	_	_
32	reaction	reaction	NOUN	NN	Number=Sing	_	_	_	_
33	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
34	RT	Rt	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
35	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
36	PCR	Pcr	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
37	)	)	PUNCT	-RRB-	_	_	_	_	_
38	and	and	CCONJ	CC	_	_	_	_	_
39	immunohistochemistry	immunohistochemistry	NOUN	NN	Number=Sing	_	_	_	_
40	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
41	IH	IH	INTJ	UH	_	_	_	_	SpaceAfter=No
42	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
43	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1052
# text = Of the 23 cases, 19 were classified as NK-cell and 4 as T-cell tumours.
1	Of	of	ADP	IN	_	_	_	_	_
2	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
3	23	23	NUM	CD	NumType=Card	_	_	_	_
4	cases	case	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
5	,	,	PUNCT	,	_	_	_	_	_
6	19	19	NUM	CD	NumType=Card	_	_	_	_
7	were	be	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
8	classified	classify	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
9	as	as	ADP	IN	_	_	_	_	_
10	NK	NK	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
11	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
12	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
13	and	and	CCONJ	CC	_	_	_	_	_
14	4	4	NUM	CD	NumType=Card	_	_	_	_
15	as	as	ADV	RB	_	_	_	_	_
16	T-	T-	SYM	NFP	_	_	_	_	SpaceAfter=No
17	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
18	tumours	tumour	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
19	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1053
# text = ISH for EBV-encoded small non-polyadenylated RNAs showed that all cases, whether NK or T, harboured EBV in virtually all tumour cells.
1	ISH	ISh	PROPN	NNP	Number=Sing	_	_	_	_
2	for	for	ADP	IN	_	_	_	_	_
3	EBV	EBV	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
4	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
5	encoded	encode	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
6	small	small	ADJ	JJ	Degree=Pos	_	_	_	_
7	non-polyadenylated	non-polyadenylated	ADJ	JJ	Degree=Pos	_	_	_	_
8	RNAs	RNA	NOUN	NNS	Number=Plur	_	_	_	_
9	showed	show	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
10	that	that	SCONJ	IN	_	_	_	_	_
11	all	all	DET	DT	_	_	_	_	_
12	cases	case	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
13	,	,	PUNCT	,	_	_	_	_	_
14	whether	whether	SCONJ	IN	_	_	_	_	_
15	NK	NK	PROPN	NNP	Number=Sing	_	_	_	_
16	or	or	CCONJ	CC	_	_	_	_	_
17	T	t	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
18	,	,	PUNCT	,	_	_	_	_	_
19	harboured	harboure	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
20	EBV	EBV	PROPN	NNP	Number=Sing	_	_	_	_
21	in	in	ADP	IN	_	_	_	_	_
22	virtually	virtually	ADV	RB	_	_	_	_	_
23	all	all	DET	PDT	_	_	_	_	_
24	tumour	tumour	NUM	CD	NumType=Card	_	_	_	_
25	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
26	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1054
# text = RT-PCR demonstrated that NL of both subtypes expressed EBNAI of the QUK splice pattern, the latent membrane proteins, LMP1 and 2 and the BamHI A rightward transcripts in the absence of EBNA2 mRNAs, compatible with the latency type II pattern.
1	RT	Rt	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
2	-PCR	-PCR	PROPN	NNP	Number=Sing	_	_	_	_
3	demonstrated	demonstrate	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
4	that	that	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
5	NL	Nl	NOUN	NN	Number=Sing	_	_	_	_
6	of	of	ADP	IN	_	_	_	_	_
7	both	both	DET	DT	_	_	_	_	_
8	subtypes	subtype	NOUN	NNS	Number=Plur	_	_	_	_
9	expressed	express	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
10	EBNAI	EBNAI	NOUN	NNS	Number=Plur	_	_	_	_
11	of	of	ADP	IN	_	_	_	_	_
12	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
13	QUK	QUK	PROPN	NNP	Number=Sing	_	_	_	_
14	splice	splice	NOUN	NN	Number=Sing	_	_	_	_
15	pattern	pattern	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
16	,	,	PUNCT	,	_	_	_	_	_
17	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
18	latent	latent	ADJ	JJ	Degree=Pos	_	_	_	_
19	membrane	membrane	NOUN	NN	Number=Sing	_	_	_	_
20	proteins	protein	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
21	,	,	PUNCT	,	_	_	_	_	_
22	LMP1	LMP1	PROPN	NNP	Number=Sing	_	_	_	_
23	and	and	CCONJ	CC	_	_	_	_	_
24	2	2	NUM	CD	NumType=Card	_	_	_	_
25	and	and	CCONJ	CC	_	_	_	_	_
26	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
27	BamHI	BamHI	PROPN	NNP	Number=Sing	_	_	_	_
28	A	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
29	rightward	rightward	ADJ	JJ	Degree=Pos	_	_	_	_
30	transcripts	transcript	NOUN	NNS	Number=Plur	_	_	_	_
31	in	in	ADP	IN	_	_	_	_	_
32	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
33	absence	absence	NOUN	NN	Number=Sing	_	_	_	_
34	of	of	ADP	IN	_	_	_	_	_
35	EBNA2	EBNA2	NUM	CD	NumType=Card	_	_	_	_
36	mRNAs	mRNA	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
37	,	,	PUNCT	,	_	_	_	_	_
38	compatible	compatible	ADJ	JJ	Degree=Pos	_	_	_	_
39	with	with	ADP	IN	_	_	_	_	_
40	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
41	latency	latency	NOUN	NN	Number=Sing	_	_	_	_
42	type	type	NOUN	NN	Number=Sing	_	_	_	_
43	II	ii	NUM	CD	NumType=Card	_	_	_	_
44	pattern	pattern	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
45	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1055
# text = In addition, analysis of EBV protein expression by IH revealed a heterogeneous pattern of EBV gene expression at the single-cell level consisting of both LMP1+ and LMP1- tumour cells, suggesting a mixture of latency I and II.
1	In	in	ADP	IN	_	_	_	_	_
2	addition	addition	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
3	,	,	PUNCT	,	_	_	_	_	_
4	analysis	analysis	NOUN	NN	Number=Sing	_	_	_	_
5	of	of	ADP	IN	_	_	_	_	_
6	EBV	EBV	PROPN	NNP	Number=Sing	_	_	_	_
7	protein	protein	NOUN	NN	Number=Sing	_	_	_	_
8	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
9	by	by	ADP	IN	_	_	_	_	_
10	IH	IH	PROPN	NNP	Number=Sing	_	_	_	_
11	revealed	reveal	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
12	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
13	heterogeneous	heterogeneous	ADJ	JJ	Degree=Pos	_	_	_	_
14	pattern	pattern	NOUN	NN	Number=Sing	_	_	_	_
15	of	of	ADP	IN	_	_	_	_	_
16	EBV	EBV	PROPN	NNP	Number=Sing	_	_	_	_
17	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
18	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
19	at	at	ADP	IN	_	_	_	_	_
20	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
21	single	single	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
22	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
23	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
24	level	level	NOUN	NN	Number=Sing	_	_	_	_
25	consisting	consisting	VERB	VBG	VerbForm=Ger	_	_	_	_
26	of	of	ADP	IN	_	_	_	_	_
27	both	both	CCONJ	CC	_	_	_	_	_
28	LMP1	LMP1	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
29	+	+	SYM	SYM	_	_	_	_	_
30	and	and	CCONJ	CC	_	_	_	_	_
31	LMP1	LMP1	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
32	-	-	PUNCT	HYPH	_	_	_	_	_
33	tumour	tumour	NOUN	NN	Number=Sing	_	_	_	_
34	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
35	,	,	PUNCT	,	_	_	_	_	_
36	suggesting	suggest	VERB	VBG	VerbForm=Ger	_	_	_	_
37	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
38	mixture	mixture	NOUN	NN	Number=Sing	_	_	_	_
39	of	of	ADP	IN	_	_	_	_	_
40	latency	latency	NOUN	NN	Number=Sing	_	_	_	_
41	I	I	PRON	PRP	Case=Nom|Number=Sing|Person=1|PronType=Prs	_	_	_	_
42	and	and	CCONJ	CC	_	_	_	_	_
43	II	ii	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
44	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1056
# text = Although 2 early lytic transcripts, BZLF1 and BHRF1, were also detected in 13 and 10 cases, respectively, the lack of ZEBRA staining in any case indicates that these lytic transcripts are most likely expressed by rare cells in the biopsies entering lytic cycle.
1	Although	although	SCONJ	IN	_	_	_	_	_
2	2	2	NUM	CD	NumType=Card	_	_	_	_
3	early	early	ADJ	JJ	Degree=Pos	_	_	_	_
4	lytic	lytic	ADJ	JJ	Degree=Pos	_	_	_	_
5	transcripts	transcript	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
6	,	,	PUNCT	,	_	_	_	_	_
7	BZLF1	BZLF1	PROPN	NNP	Number=Sing	_	_	_	_
8	and	and	CCONJ	CC	_	_	_	_	_
9	BHRF1	BHRF1	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
10	,	,	PUNCT	,	_	_	_	_	_
11	were	be	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
12	also	also	ADV	RB	_	_	_	_	_
13	detected	detect	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
14	in	in	ADP	IN	_	_	_	_	_
15	13	13	NUM	CD	NumType=Card	_	_	_	_
16	and	and	CCONJ	CC	_	_	_	_	_
17	10	10	NUM	CD	NumType=Card	_	_	_	_
18	cases	case	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
19	,	,	PUNCT	,	_	_	_	_	_
20	respectively	respectively	ADV	RB	_	_	_	_	SpaceAfter=No
21	,	,	PUNCT	,	_	_	_	_	_
22	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
23	lack	lack	NOUN	NN	Number=Sing	_	_	_	_
24	of	of	ADP	IN	_	_	_	_	_
25	ZEBRA	zebra	PROPN	NNP	Number=Sing	_	_	_	_
26	staining	stai	VERB	VBG	VerbForm=Ger	_	_	_	_
27	in	in	ADP	IN	_	_	_	_	_
28	any	any	DET	DT	_	_	_	_	_
29	case	case	NOUN	NN	Number=Sing	_	_	_	_
30	indicates	indicate	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
31	that	that	SCONJ	IN	_	_	_	_	_
32	these	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
33	lytic	lytic	ADJ	JJ	Degree=Pos	_	_	_	_
34	transcripts	transcript	NOUN	NNS	Number=Plur	_	_	_	_
35	are	be	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
36	most	most	ADV	RBS	_	_	_	_	_
37	likely	likely	ADV	RB	_	_	_	_	_
38	expressed	express	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
39	by	by	ADP	IN	_	_	_	_	_
40	rare	rare	ADJ	JJ	Degree=Pos	_	_	_	_
41	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
42	in	in	ADP	IN	_	_	_	_	_
43	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
44	biopsies	biopsy	NOUN	NNS	Number=Plur	_	_	_	_
45	entering	enter	VERB	VBG	VerbForm=Ger	_	_	_	_
46	lytic	lytic	ADJ	JJ	Degree=Pos	_	_	_	_
47	cycle	cycle	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
48	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1057
# text = The viral transcriptional pattern similar to that of nasopharyngeal carcinoma and Hodgkin's disease suggests that EBV can exploit common regulatory mechanisms for gene transcription in diverse host cell types.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	viral	viral	ADJ	JJ	Degree=Pos	_	_	_	_
3	transcriptional	transcriptional	ADJ	JJ	Degree=Pos	_	_	_	_
4	pattern	pattern	NOUN	NN	Number=Sing	_	_	_	_
5	similar	similar	ADJ	JJ	Degree=Pos	_	_	_	_
6	to	to	ADP	IN	_	_	_	_	_
7	that	that	PRON	DT	Number=Sing|PronType=Dem	_	_	_	_
8	of	of	ADP	IN	_	_	_	_	_
9	nasopharyngeal	nasopharyngeal	ADJ	JJ	Degree=Pos	_	_	_	_
10	carcinoma	carcinoma	NOUN	NN	Number=Sing	_	_	_	_
11	and	and	CCONJ	CC	_	_	_	_	_
12	Hodgkin	Hodgkin	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
13	's	's	PART	POS	_	_	_	_	_
14	disease	disease	NOUN	NN	Number=Sing	_	_	_	_
15	suggests	suggest	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
16	that	that	SCONJ	IN	_	_	_	_	_
17	EBV	EBV	PROPN	NNP	Number=Sing	_	_	_	_
18	can	can	AUX	MD	VerbForm=Fin	_	_	_	_
19	exploit	exploit	VERB	VB	VerbForm=Inf	_	_	_	_
20	common	common	ADJ	JJ	Degree=Pos	_	_	_	_
21	regulatory	regulatory	ADJ	JJ	Degree=Pos	_	_	_	_
22	mechanisms	mechanism	NOUN	NNS	Number=Plur	_	_	_	_
23	for	for	ADP	IN	_	_	_	_	_
24	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
25	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
26	in	in	ADP	IN	_	_	_	_	_
27	diverse	diverse	ADJ	JJ	Degree=Pos	_	_	_	_
28	host	host	NOUN	NN	Number=Sing	_	_	_	_
29	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
30	types	type	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
31	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1058
# text = Down-regulation of immunogenic proteins (EBNA2-EBNA6) in nasal lymphoma may enable tumour cells to evade host cytotoxic T-cell surveillance.
1	Down	down	ADV	RB	_	_	_	_	SpaceAfter=No
2	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
3	regulation	regulation	NOUN	NN	Number=Sing	_	_	_	_
4	of	of	ADP	IN	_	_	_	_	_
5	immunogenic	immunogenic	ADJ	JJ	Degree=Pos	_	_	_	_
6	proteins	protein	NOUN	NNS	Number=Plur	_	_	_	_
7	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
8	EBNA2	EBNA2	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
9	-	-	SYM	SYM	_	_	_	_	SpaceAfter=No
10	EBNA6	EBNA6	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
11	)	)	PUNCT	-RRB-	_	_	_	_	_
12	in	in	ADP	IN	_	_	_	_	_
13	nasal	nasal	ADJ	JJ	Degree=Pos	_	_	_	_
14	lymphoma	lymphoma	NOUN	NN	Number=Sing	_	_	_	_
15	may	may	AUX	MD	VerbForm=Fin	_	_	_	_
16	enable	enable	VERB	VB	VerbForm=Inf	_	_	_	_
17	tumour	tumour	PRON	PRP$	Person=2|Poss=Yes|PronType=Prs	_	_	_	_
18	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
19	to	to	PART	TO	_	_	_	_	_
20	evade	evade	VERB	VB	VerbForm=Inf	_	_	_	_
21	host	host	NOUN	NN	Number=Sing	_	_	_	_
22	cytotoxic	cytotoxic	NOUN	NN	Number=Sing	_	_	_	_
23	T-	t-	PUNCT	:	_	_	_	_	SpaceAfter=No
24	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
25	surveillance	surveillance	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
26	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 1059
# text = Document 003002373 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	003002373	003002373	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 1060
# text = Stimulation of CD40 on immunogenic human malignant melanomas augments their cytotoxic T lymphocyte-mediated lysis and induces apoptosis.
1	Stimulation	Stimulation	NOUN	NN	Number=Sing	_	_	_	_
2	of	of	ADP	IN	_	_	_	_	_
3	CD40	CD40	PROPN	NNP	Number=Sing	_	_	_	_
4	on	on	ADP	IN	_	_	_	_	_
5	immunogenic	immunogenic	ADJ	JJ	Degree=Pos	_	_	_	_
6	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
7	malignant	malignant	ADJ	JJ	Degree=Pos	_	_	_	_
8	melanomas	melanoma	NOUN	NNS	Number=Plur	_	_	_	_
9	augments	augment	NOUN	NNS	Number=Plur	_	_	_	_
10	their	they	PRON	PRP$	Number=Plur|Person=3|Poss=Yes|PronType=Prs	_	_	_	_
11	cytotoxic	cytotoxic	ADJ	JJ	Degree=Pos	_	_	_	_
12	T	T	PROPN	NNP	Number=Sing	_	_	_	_
13	lymphocyte	lymphocyte	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
14	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
15	mediated	mediate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
16	lysis	lysis	NOUN	NN	Number=Sing	_	_	_	_
17	and	and	CCONJ	CC	_	_	_	_	_
18	induces	induce	NOUN	NNS	Number=Plur	_	_	_	_
19	apoptosis	apoptosis	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	SpaceAfter=No
20	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 1061
# text = Here, we report the functional expression of CD40 on human malignant melanomas (MMs).
1	Here	here	ADV	RB	PronType=Dem	_	_	_	SpaceAfter=No
2	,	,	PUNCT	,	_	_	_	_	_
3	we	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
4	report	report	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
5	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
6	functional	functional	ADJ	JJ	Degree=Pos	_	_	_	_
7	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
8	of	of	ADP	IN	_	_	_	_	_
9	CD40	CD40	NUM	CD	NumType=Card	_	_	_	_
10	on	on	ADP	IN	_	_	_	_	_
11	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
12	malignant	malignant	ADJ	JJ	Degree=Pos	_	_	_	_
13	melanomas	melanoma	NOUN	NNS	Number=Plur	_	_	_	_
14	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
15	MMs	Mms	PROPN	NNPS	Number=Plur	_	_	_	SpaceAfter=No
16	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
17	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1062
# text = Comparison of tumor specimen from MM precursor lesions, primary tumors, and metastases revealed that CD40 surface expression is down-regulated during tumor progression.
1	Comparison	Comparison	NOUN	NN	Number=Sing	_	_	_	_
2	of	of	ADP	IN	_	_	_	_	_
3	tumor	tumor	NOUN	NN	Number=Sing	_	_	_	_
4	specimen	speciman	NOUN	NN	Number=Sing	_	_	_	_
5	from	from	ADP	IN	_	_	_	_	_
6	MM	mm	NUM	CD	NumType=Card	_	_	_	_
7	precursor	precursor	NOUN	NN	Number=Sing	_	_	_	_
8	lesions	lesion	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
9	,	,	PUNCT	,	_	_	_	_	_
10	primary	primary	ADJ	JJ	Degree=Pos	_	_	_	_
11	tumors	tumor	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
12	,	,	PUNCT	,	_	_	_	_	_
13	and	and	CCONJ	CC	_	_	_	_	_
14	metastases	metastase	NOUN	NNS	Number=Plur	_	_	_	_
15	revealed	reveal	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
16	that	that	SCONJ	IN	_	_	_	_	_
17	CD40	CD40	PROPN	NNP	Number=Sing	_	_	_	_
18	surface	surface	NOUN	NN	Number=Sing	_	_	_	_
19	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
20	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
21	down	down	ADV	RB	_	_	_	_	SpaceAfter=No
22	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
23	regulated	regulate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
24	during	during	ADP	IN	_	_	_	_	_
25	tumor	tumor	NOUN	NN	Number=Sing	_	_	_	_
26	progression	progression	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
27	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1063
# text = CD40 expression was confirmed in 7 human MM cell lines established from immunogenic primary tumors or metastases, whereas 11 cell lines established from advanced stages were CD40 negative.
1	CD40	CD40	NUM	CD	NumType=Card	_	_	_	_
2	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
3	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
4	confirmed	confirm	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
5	in	in	ADP	IN	_	_	_	_	_
6	7	7	NUM	CD	NumType=Card	_	_	_	_
7	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
8	MM	mm	NUM	CD	NumType=Card	_	_	_	_
9	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
10	lines	line	NOUN	NNS	Number=Plur	_	_	_	_
11	established	establish	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
12	from	from	ADP	IN	_	_	_	_	_
13	immunogenic	immunogenic	ADJ	JJ	Degree=Pos	_	_	_	_
14	primary	primary	ADJ	JJ	Degree=Pos	_	_	_	_
15	tumors	tumor	NOUN	NNS	Number=Plur	_	_	_	_
16	or	or	CCONJ	CC	_	_	_	_	_
17	metastases	metastase	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
18	,	,	PUNCT	,	_	_	_	_	_
19	whereas	whereas	SCONJ	IN	_	_	_	_	_
20	11	11	NUM	CD	NumType=Card	_	_	_	_
21	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
22	lines	line	NOUN	NNS	Number=Plur	_	_	_	_
23	established	establish	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
24	from	from	ADP	IN	_	_	_	_	_
25	advanced	advanced	ADJ	JJ	Degree=Pos	_	_	_	_
26	stages	stage	NOUN	NNS	Number=Plur	_	_	_	_
27	were	be	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
28	CD40	CD40	PROPN	NNP	Number=Sing	_	_	_	_
29	negative	negative	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
30	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1064
# text = CD40 expression could be enhanced in CD40-positive MM by stimulation with IFN-gamma and tumor necrosis factor-alpha but not by interleukin (IL)-1beta or CD40 triggering.
1	CD40	CD40	NOUN	NN	Number=Sing	_	_	_	_
2	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
3	could	could	AUX	MD	VerbForm=Fin	_	_	_	_
4	be	be	AUX	VB	VerbForm=Inf	_	_	_	_
5	enhanced	enhance	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
6	in	in	ADP	IN	_	_	_	_	_
7	CD40	CD40	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
8	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
9	positive	positive	ADJ	JJ	Degree=Pos	_	_	_	_
10	MM	mm	PROPN	NNP	Number=Sing	_	_	_	_
11	by	by	ADP	IN	_	_	_	_	_
12	stimulation	stimulation	NOUN	NN	Number=Sing	_	_	_	_
13	with	with	ADP	IN	_	_	_	_	_
14	IFN-	Ifn-	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
15	gamma	gamma	NOUN	NN	Number=Sing	_	_	_	_
16	and	and	CCONJ	CC	_	_	_	_	_
17	tumor	tumor	NOUN	NN	Number=Sing	_	_	_	_
18	necrosis	necrosis	NOUN	NN	Number=Sing	_	_	_	_
19	factor	factor	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
20	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
21	alpha	alpha	NOUN	NN	Number=Sing	_	_	_	_
22	but	but	CCONJ	CC	_	_	_	_	_
23	not	not	ADV	RB	_	_	_	_	_
24	by	by	ADP	IN	_	_	_	_	_
25	interleukin	interleukin	NOUN	NN	Number=Sing	_	_	_	_
26	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
27	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
28	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
29	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
30	1	1	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
31	beta	beta	NOUN	NN	Number=Sing	_	_	_	_
32	or	or	CCONJ	CC	_	_	_	_	_
33	CD40	CD40	PROPN	NNP	Number=Sing	_	_	_	_
34	triggering	triggering	VERB	VBG	VerbForm=Ger	_	_	_	SpaceAfter=No
35	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1065
# text = CD40 ligation on MM by CD40L-transfected murine L-cells or by a soluble CD40L fusion protein up-regulated their expression of intercellular adhesion molecule-1 and MHC class I and class II molecules and their secretion of IL-6, IL-8, tumor necrosis factor-a, and granulocyte macrophage colony-stimulating factor and also induced a rapid activation of the transcription factor nuclear factor kappaB.
1	CD40	CD40	NUM	CD	NumType=Card	_	_	_	_
2	ligation	ligation	NOUN	NN	Number=Sing	_	_	_	_
3	on	on	ADP	IN	_	_	_	_	_
4	MM	mm	PROPN	NNP	Number=Sing	_	_	_	_
5	by	by	ADP	IN	_	_	_	_	_
6	CD40L	CD40L	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
7	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
8	transfected	transfect	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
9	murine	murine	PRON	PRP	_	_	_	_	_
10	L-	L-	SYM	NFP	_	_	_	_	SpaceAfter=No
11	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
12	or	or	CCONJ	CC	_	_	_	_	_
13	by	by	ADP	IN	_	_	_	_	_
14	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
15	soluble	soluble	ADJ	JJ	Degree=Pos	_	_	_	_
16	CD40L	Cd40l	NOUN	NN	Number=Sing	_	_	_	_
17	fusion	fusion	NOUN	NN	Number=Sing	_	_	_	_
18	protein	protein	NOUN	NN	Number=Sing	_	_	_	_
19	up	up	ADV	RB	_	_	_	_	SpaceAfter=No
20	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
21	regulated	regulate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
22	their	they	PRON	PRP$	Number=Plur|Person=3|Poss=Yes|PronType=Prs	_	_	_	_
23	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
24	of	of	ADP	IN	_	_	_	_	_
25	intercellular	intercellular	ADJ	JJ	Degree=Pos	_	_	_	_
26	adhesion	adhesion	NOUN	NN	Number=Sing	_	_	_	_
27	molecule	molecule	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
28	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
29	1	1	NUM	CD	NumType=Card	_	_	_	_
30	and	and	CCONJ	CC	_	_	_	_	_
31	MHC	MHC	PROPN	NNP	Number=Sing	_	_	_	_
32	class	class	NOUN	NN	Number=Sing	_	_	_	_
33	I	I	PRON	PRP	Case=Nom|Number=Sing|Person=1|PronType=Prs	_	_	_	_
34	and	and	CCONJ	CC	_	_	_	_	_
35	class	class	NOUN	NN	Number=Sing	_	_	_	_
36	II	ii	NUM	CD	NumType=Card	_	_	_	_
37	molecules	molecule	NOUN	NNS	Number=Plur	_	_	_	_
38	and	and	CCONJ	CC	_	_	_	_	_
39	their	they	PRON	PRP$	Number=Plur|Person=3|Poss=Yes|PronType=Prs	_	_	_	_
40	secretion	secretion	NOUN	NN	Number=Sing	_	_	_	_
41	of	of	ADP	IN	_	_	_	_	_
42	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
43	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
44	6	6	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
45	,	,	PUNCT	,	_	_	_	_	_
46	IL	Il	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
47	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
48	8	8	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
49	,	,	PUNCT	,	_	_	_	_	_
50	tumor	tumor	NOUN	NN	Number=Sing	_	_	_	_
51	necrosis	necrosis	NOUN	NN	Number=Sing	_	_	_	_
52	factor	factor	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
53	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
54	a	a	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
55	,	,	PUNCT	,	_	_	_	_	_
56	and	and	CCONJ	CC	_	_	_	_	_
57	granulocyte	granulocyte	ADJ	JJ	Degree=Pos	_	_	_	_
58	macrophage	macrophage	NOUN	NN	Number=Sing	_	_	_	_
59	colony	colony	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
60	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
61	stimulating	stimulating	NOUN	NN	Number=Sing	_	_	_	_
62	factor	factor	NOUN	NN	Number=Sing	_	_	_	_
63	and	and	CCONJ	CC	_	_	_	_	_
64	also	also	ADV	RB	_	_	_	_	_
65	induced	induce	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
66	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
67	rapid	rapid	ADJ	JJ	Degree=Pos	_	_	_	_
68	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
69	of	of	ADP	IN	_	_	_	_	_
70	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
71	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
72	factor	factor	NOUN	NN	Number=Sing	_	_	_	_
73	nuclear	nuclear	ADJ	JJ	Degree=Pos	_	_	_	_
74	factor	factor	NOUN	NN	Number=Sing	_	_	_	_
75	kappaB	kappaB	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
76	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1066
# text = Furthermore, CD40 ligation of a HLA-A2+, MelanA/MART1+
1	Furthermore	furthermore	ADV	RB	_	_	_	_	SpaceAfter=No
2	,	,	PUNCT	,	_	_	_	_	_
3	CD40	CD40	NUM	CD	NumType=Card	_	_	_	_
4	ligation	ligation	NOUN	NN	Number=Sing	_	_	_	_
5	of	of	ADP	IN	_	_	_	_	_
6	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
7	HLA	HLa	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
8	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
9	A2+	a2+	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
10	,	,	PUNCT	,	_	_	_	_	_
11	MelanA	MelanA	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
12	/	/	PUNCT	,	_	_	_	_	SpaceAfter=No
13	MART1	MART1	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
14	+	+	SYM	NFP	_	_	_	_	_

# sent_id = 1067
# text = MM
1	MM	mm	X	ADD	_	_	_	_	_

# sent_id = 1068
# text = cell line enhanced its susceptibility to specific lysis by a HLA-A2-restricted, MelanA/MART-1-specific
1	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
2	line	line	NOUN	NN	Number=Sing	_	_	_	_
3	enhanced	enhance	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
4	its	its	PRON	PRP$	Gender=Neut|Number=Sing|Person=3|Poss=Yes|PronType=Prs	_	_	_	_
5	susceptibility	susceptibility	NOUN	NN	Number=Sing	_	_	_	_
6	to	to	ADP	IN	_	_	_	_	_
7	specific	specific	ADJ	JJ	Degree=Pos	_	_	_	_
8	lysis	lysis	NOUN	NN	Number=Sing	_	_	_	_
9	by	by	ADP	IN	_	_	_	_	_
10	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
11	HLA	HLa	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
12	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
13	A2	a2	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
14	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
15	restricted	restrict	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	SpaceAfter=No
16	,	,	PUNCT	,	_	_	_	_	_
17	MelanA/	MelanA/	ADP	IN	Abbr=Yes	_	_	_	SpaceAfter=No
18	MART	Mart	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
19	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
20	1	1	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
21	-specific	-specific	ADJ	JJ	Degree=Pos	_	_	_	_

# sent_id = 1069
# text = CTL clone.
1	CTL	Ctl	ADJ	JJ	Degree=Pos	_	_	_	_
2	clone	clone	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
3	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1070
# text = Finally, CD40 ligation induced growth inhibition and apoptosis in MM.
1	Finally	finally	ADV	RB	_	_	_	_	SpaceAfter=No
2	,	,	PUNCT	,	_	_	_	_	_
3	CD40	CD40	NUM	CD	NumType=Card	_	_	_	_
4	ligation	ligation	NOUN	NN	Number=Sing	_	_	_	_
5	induced	induce	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
6	growth	growth	NOUN	NN	Number=Sing	_	_	_	_
7	inhibition	inhibition	NOUN	NN	Number=Sing	_	_	_	_
8	and	and	CCONJ	CC	_	_	_	_	_
9	apoptosis	apoptosis	NOUN	NN	Number=Sing	_	_	_	_
10	in	in	ADP	IN	_	_	_	_	_
11	MM	mm	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
12	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1071
# text = These results indicate that CD40-CD40L interactions may play an important role in augmenting antitumor immunity and inducing apoptosis in some CD40-positive immunogenic human MMs.
1	These	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
2	results	result	NOUN	NNS	Number=Plur	_	_	_	_
3	indicate	indicate	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
4	that	that	SCONJ	IN	_	_	_	_	_
5	CD40-	Cd40-	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
6	CD40L	Cd40l	NOUN	NN	Number=Sing	_	_	_	_
7	interactions	interaction	NOUN	NNS	Number=Plur	_	_	_	_
8	may	may	AUX	MD	VerbForm=Fin	_	_	_	_
9	play	play	VERB	VB	VerbForm=Inf	_	_	_	_
10	an	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
11	important	important	ADJ	JJ	Degree=Pos	_	_	_	_
12	role	role	NOUN	NN	Number=Sing	_	_	_	_
13	in	in	SCONJ	IN	_	_	_	_	_
14	augmenting	augment	VERB	VBG	VerbForm=Ger	_	_	_	_
15	antitumor	antitumor	NOUN	NN	Number=Sing	_	_	_	_
16	immunity	immunity	NOUN	NN	Number=Sing	_	_	_	_
17	and	and	CCONJ	CC	_	_	_	_	_
18	inducing	induce	VERB	VBG	VerbForm=Ger	_	_	_	_
19	apoptosis	apoptosis	NOUN	NN	Number=Sing	_	_	_	_
20	in	in	ADP	IN	_	_	_	_	_
21	some	some	DET	DT	_	_	_	_	_
22	CD40	CD40	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
23	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
24	positive	positive	ADJ	JJ	Degree=Pos	_	_	_	_
25	immunogenic	immunogenic	ADJ	JJ	Degree=Pos	_	_	_	_
26	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
27	MMs	MM	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
28	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 1072
# text = Document 003002382 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	003002382	003002382	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 1073
# text = Involvement of adenylate cyclase and p70(S6)-kinase activation in IL-10 up-regulation in human monocytes by gp41 envelope protein of human immunodeficiency virus type 1.
1	Involvement	involvement	NOUN	NN	Number=Sing	_	_	_	_
2	of	of	ADP	IN	_	_	_	_	_
3	adenylate	adenylate	ADJ	JJ	Degree=Pos	_	_	_	_
4	cyclase	cyclase	NOUN	NN	Number=Sing	_	_	_	_
5	and	and	CCONJ	CC	_	_	_	_	_
6	p70	p70	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
7	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
8	S6	S6	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
9	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
10	-	-	PUNCT	:	_	_	_	_	SpaceAfter=No
11	kinase	kinase	NOUN	NN	Number=Sing	_	_	_	_
12	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
13	in	in	ADP	IN	_	_	_	_	_
14	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
15	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
16	10	10	NUM	CD	NumType=Card	_	_	_	_
17	up	up	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
18	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
19	regulation	regulation	NOUN	NN	Number=Sing	_	_	_	_
20	in	in	ADP	IN	_	_	_	_	_
21	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
22	monocytes	monocyte	NOUN	NNS	Number=Plur	_	_	_	_
23	by	by	ADP	IN	_	_	_	_	_
24	gp41	gp41	NUM	CD	NumType=Card	_	_	_	_
25	envelope	envelope	NOUN	NN	Number=Sing	_	_	_	_
26	protein	protein	NOUN	NN	Number=Sing	_	_	_	_
27	of	of	ADP	IN	_	_	_	_	_
28	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
29	immunodeficiency	immunodeficiency	NOUN	NN	Number=Sing	_	_	_	_
30	virus	virus	NOUN	NN	Number=Sing	_	_	_	_
31	type	type	NOUN	NN	Number=Sing	_	_	_	_
32	1	1	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
33	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 1074
# text = Our previous results show that recombinant gp41 (aa565-647), the extracellular domain of HIV-1 transmembrane glycoprotein, stimulates interleukin-10 (IL-10) production in human monocytes.
1	Our	we	PRON	PRP$	Number=Plur|Person=1|Poss=Yes|PronType=Prs	_	_	_	_
2	previous	previous	ADJ	JJ	Degree=Pos	_	_	_	_
3	results	result	NOUN	NNS	Number=Plur	_	_	_	_
4	show	show	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
5	that	that	SCONJ	IN	_	_	_	_	_
6	recombinant	recombinant	ADJ	JJ	Degree=Pos	_	_	_	_
7	gp41	gp41	NOUN	NN	Number=Sing	_	_	_	_
8	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
9	aa565-	aa565-	SYM	SYM	_	_	_	_	SpaceAfter=No
10	647	647	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
11	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
12	,	,	PUNCT	,	_	_	_	_	_
13	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
14	extracellular	extracellular	ADJ	JJ	Degree=Pos	_	_	_	_
15	domain	domain	NOUN	NN	Number=Sing	_	_	_	_
16	of	of	ADP	IN	_	_	_	_	_
17	HIV	HIV	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
18	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
19	1	1	NUM	CD	NumType=Card	_	_	_	_
20	transmembrane	transmembrane	NOUN	NN	Number=Sing	_	_	_	_
21	glycoprotein	glycoprotein	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
22	,	,	PUNCT	,	_	_	_	_	_
23	stimulates	stimulate	NOUN	NNS	Number=Plur	_	_	_	_
24	interleukin	interleukin	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	SpaceAfter=No
25	-10	-10	NUM	CD	NumType=Card	_	_	_	_
26	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
27	IL	Il	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
28	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
29	10	10	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
30	)	)	PUNCT	-RRB-	_	_	_	_	_
31	production	production	NOUN	NN	Number=Sing	_	_	_	_
32	in	in	ADP	IN	_	_	_	_	_
33	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
34	monocytes	monocyte	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
35	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1075
# text = The signal cascade transducing this effect is not yet clear.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	signal	signal	NOUN	NN	Number=Sing	_	_	_	_
3	cascade	cascade	NOUN	NN	Number=Sing	_	_	_	_
4	transducing	transduce	VERB	VBG	VerbForm=Ger	_	_	_	_
5	this	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
6	effect	effect	NOUN	NN	Number=Sing	_	_	_	_
7	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
8	not	not	PART	RB	_	_	_	_	_
9	yet	yet	ADV	RB	_	_	_	_	_
10	clear	clear	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
11	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1076
# text = In this study, we examined whether gp41-induced IL-10 up-regulation is mediated by the previously described synergistic activation of cAMP and NF-kappaB pathways.
1	In	in	ADP	IN	_	_	_	_	_
2	this	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
3	study	study	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
4	,	,	PUNCT	,	_	_	_	_	_
5	we	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
6	examined	examin	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
7	whether	whether	SCONJ	IN	_	_	_	_	_
8	gp41	gp41	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
9	-induced	-induce	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
10	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
11	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
12	10	10	NUM	CD	NumType=Card	_	_	_	_
13	up	up	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
14	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
15	regulation	regulation	NOUN	NN	Number=Sing	_	_	_	_
16	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
17	mediated	mediate	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
18	by	by	ADP	IN	_	_	_	_	_
19	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
20	previously	previously	ADV	RB	_	_	_	_	_
21	described	describe	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
22	synergistic	synergistic	ADJ	JJ	Degree=Pos	_	_	_	_
23	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
24	of	of	ADP	IN	_	_	_	_	_
25	cAMP	camp	PROPN	NNP	Number=Sing	_	_	_	_
26	and	and	CCONJ	CC	_	_	_	_	_
27	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
28	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
29	kappaB	kappaB	PROPN	NNP	Number=Sing	_	_	_	_
30	pathways	pathway	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
31	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1077
# text = gp41 induced cAMP accumulation in monocytes in a time- and concentration-dependent manner and the adenylate cyclase inhibitor SQ 22536 suppressed gp41-induced IL-10 production in monocytes.
1	gp41	gp41	X	LS	_	_	_	_	_
2	induced	induce	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
3	cAMP	camp	NOUN	NN	Number=Sing	_	_	_	_
4	accumulation	accumulation	NOUN	NN	Number=Sing	_	_	_	_
5	in	in	ADP	IN	_	_	_	_	_
6	monocytes	monocyte	NOUN	NNS	Number=Plur	_	_	_	_
7	in	in	ADP	IN	_	_	_	_	_
8	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
9	time	time	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
10	-	-	PUNCT	,	_	_	_	_	_
11	and	and	CCONJ	CC	_	_	_	_	_
12	concentration	concentration	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
13	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
14	dependent	dependent	ADJ	JJ	Degree=Pos	_	_	_	_
15	manner	manner	NOUN	NN	Number=Sing	_	_	_	_
16	and	and	CCONJ	CC	_	_	_	_	_
17	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
18	adenylate	adenylate	ADJ	JJ	Degree=Pos	_	_	_	_
19	cyclase	cyclase	NOUN	NN	Number=Sing	_	_	_	_
20	inhibitor	inhibitor	NOUN	NN	Number=Sing	_	_	_	_
21	SQ	sq	NOUN	NN	Number=Sing	_	_	_	_
22	22536	22536	NUM	CD	NumType=Card	_	_	_	_
23	suppressed	suppress	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
24	gp41	gp41	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
25	-induced	-induce	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
26	IL	Il	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
27	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
28	10	10	NUM	CD	NumType=Card	_	_	_	_
29	production	production	NOUN	NN	Number=Sing	_	_	_	_
30	in	in	ADP	IN	_	_	_	_	_
31	monocytes	monocyte	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
32	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1078
# text = In contrast, gp41 failed to stimulate NF-kappaB binding activity in as much as no NF-kappaB bound to the main NF-kappaB-binding site 2 of the IL-10 promoter after addition of gp41.
1	In	in	ADP	IN	_	_	_	_	_
2	contrast	contrast	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
3	,	,	PUNCT	,	_	_	_	_	_
4	gp41	gp41	NUM	CD	NumType=Card	_	_	_	_
5	failed	fail	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
6	to	to	PART	TO	_	_	_	_	_
7	stimulate	stimulate	VERB	VB	VerbForm=Inf	_	_	_	_
8	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
9	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
10	kappaB	kappaB	PROPN	NNP	Number=Sing	_	_	_	_
11	binding	bind	VERB	VBG	VerbForm=Ger	_	_	_	_
12	activity	activity	NOUN	NN	Number=Sing	_	_	_	_
13	in	in	ADP	IN	_	_	_	_	_
14	as	as	ADV	RB	_	_	_	_	_
15	much	much	ADJ	JJ	Degree=Pos	_	_	_	_
16	as	as	ADP	IN	_	_	_	_	_
17	no	no	DET	DT	_	_	_	_	_
18	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
19	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
20	kappaB	kappaB	PROPN	NNP	Number=Sing	_	_	_	_
21	bound	bound	ADJ	JJ	Degree=Pos	_	_	_	_
22	to	to	ADP	IN	_	_	_	_	_
23	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
24	main	main	ADJ	JJ	Degree=Pos	_	_	_	_
25	NF	Nf	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
26	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
27	kappaB-	kappab-	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
28	binding	binding	VERB	VBG	VerbForm=Ger	_	_	_	_
29	site	site	NOUN	NN	Number=Sing	_	_	_	_
30	2	2	NUM	CD	NumType=Card	_	_	_	_
31	of	of	ADP	IN	_	_	_	_	_
32	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
33	IL	Il	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
34	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
35	10	10	NUM	CD	NumType=Card	_	_	_	_
36	promoter	promoter	NOUN	NN	Number=Sing	_	_	_	_
37	after	after	ADP	IN	_	_	_	_	_
38	addition	addition	NOUN	NN	Number=Sing	_	_	_	_
39	of	of	ADP	IN	_	_	_	_	_
40	gp41	gp41	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
41	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1079
# text = We also examined the involvement of other signal transduction pathways.
1	We	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
2	also	also	ADV	RB	_	_	_	_	_
3	examined	examin	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
4	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
5	involvement	involvement	NOUN	NN	Number=Sing	_	_	_	_
6	of	of	ADP	IN	_	_	_	_	_
7	other	other	ADJ	JJ	Degree=Pos	_	_	_	_
8	signal	signal	NOUN	NN	Number=Sing	_	_	_	_
9	transduction	transduction	NOUN	NN	Number=Sing	_	_	_	_
10	pathways	pathway	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
11	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1080
# text = Specific inhibitors of p70(S6)-kinase (rapamycin), and Gi protein (pertussis toxin), prevented induction of IL-10 production by gp41 in monocytes, while inhibitors of the phosphatidylinositol 3-kinase (PI 3-kinase) (wortmannin) and mitogen-activated protein kinase (MAPK) pathway (PD 98059) did not.
1	Specific	specific	ADJ	JJ	Degree=Pos	_	_	_	_
2	inhibitors	inhibitor	NOUN	NNS	Number=Plur	_	_	_	_
3	of	of	ADP	IN	_	_	_	_	_
4	p70	p70	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
5	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
6	S6	s6	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
7	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
8	-	-	PUNCT	:	_	_	_	_	SpaceAfter=No
9	kinase	kinase	NOUN	NN	Number=Sing	_	_	_	_
10	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
11	rapamycin	rapamycin	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
12	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
13	,	,	PUNCT	,	_	_	_	_	_
14	and	and	CCONJ	CC	_	_	_	_	_
15	Gi	gi	PROPN	NNP	Number=Sing	_	_	_	_
16	protein	protein	NOUN	NN	Number=Sing	_	_	_	_
17	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
18	pertussis	pertussis	NOUN	NN	Number=Sing	_	_	_	_
19	toxin	toxin	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
20	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
21	,	,	PUNCT	,	_	_	_	_	_
22	prevented	prevent	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
23	induction	induction	NOUN	NN	Number=Sing	_	_	_	_
24	of	of	ADP	IN	_	_	_	_	_
25	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
26	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
27	10	10	NUM	CD	NumType=Card	_	_	_	_
28	production	production	NOUN	NN	Number=Sing	_	_	_	_
29	by	by	ADP	IN	_	_	_	_	_
30	gp41	gp41	NUM	CD	NumType=Card	_	_	_	_
31	in	in	ADP	IN	_	_	_	_	_
32	monocytes	monocyte	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
33	,	,	PUNCT	,	_	_	_	_	_
34	while	while	SCONJ	IN	_	_	_	_	_
35	inhibitors	inhibitor	NOUN	NNS	Number=Plur	_	_	_	_
36	of	of	ADP	IN	_	_	_	_	_
37	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
38	phosphatidylinositol	phosphatidylinositol	NOUN	NN	Number=Sing	_	_	_	_
39	3	3	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
40	-	-	PUNCT	:	_	_	_	_	SpaceAfter=No
41	kinase	kinase	NOUN	NN	Number=Sing	_	_	_	_
42	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
43	PI	Pi	NUM	CD	NumType=Card	_	_	_	_
44	3	3	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
45	-	-	PUNCT	:	_	_	_	_	SpaceAfter=No
46	kinase	kinase	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
47	)	)	PUNCT	-RRB-	_	_	_	_	_
48	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
49	wortmannin	wortmannin	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
50	)	)	PUNCT	-RRB-	_	_	_	_	_
51	and	and	CCONJ	CC	_	_	_	_	_
52	mitogen	mitogen	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
53	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
54	activated	activate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
55	protein	protein	NOUN	NN	Number=Sing	_	_	_	_
56	kinase	kinase	NOUN	NN	Number=Sing	_	_	_	_
57	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
58	MAPK	MAPK	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
59	)	)	PUNCT	-RRB-	_	_	_	_	_
60	pathway	pathway	NOUN	NN	Number=Sing	_	_	_	_
61	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
62	PD	P	NOUN	NN	Number=Sing	_	_	_	_
63	98059	98059	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
64	)	)	PUNCT	-RRB-	_	_	_	_	_
65	did	do	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
66	not	not	PART	RB	_	_	_	_	SpaceAfter=No
67	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1081
# text = Thus HIV-1 gp41-induced IL-10 up-regulation in monocytes may not involve NF-kappaB, MAPK, or PI 3-kinase activation, but rather may operate through activation of adenylate cyclase and pertussis-toxin-sensitive Gi/Go protein to effect p70(S6)-kinase activation.
1	Thus	thus	PROPN	NNP	Number=Sing	_	_	_	_
2	HIV	HIV	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
3	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
4	1	1	NUM	CD	NumType=Card	_	_	_	_
5	gp41	gp41	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
6	-induced	-induce	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
7	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
8	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
9	10	10	NUM	CD	NumType=Card	_	_	_	_
10	up	up	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
11	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
12	regulation	regulation	NOUN	NN	Number=Sing	_	_	_	_
13	in	in	ADP	IN	_	_	_	_	_
14	monocytes	monocyte	NOUN	NNS	Number=Plur	_	_	_	_
15	may	may	AUX	MD	VerbForm=Fin	_	_	_	_
16	not	not	PART	RB	_	_	_	_	_
17	involve	involve	VERB	VB	VerbForm=Inf	_	_	_	_
18	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
19	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
20	kappaB	kappaB	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
21	,	,	PUNCT	,	_	_	_	_	_
22	MAPK	MAPK	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
23	,	,	PUNCT	,	_	_	_	_	_
24	or	or	CCONJ	CC	_	_	_	_	_
25	PI	PI	PROPN	NNP	Number=Sing	_	_	_	_
26	3	3	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
27	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
28	kinase	kinase	NOUN	NN	Number=Sing	_	_	_	_
29	activation	activation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
30	,	,	PUNCT	,	_	_	_	_	_
31	but	but	CCONJ	CC	_	_	_	_	_
32	rather	rather	ADV	RB	_	_	_	_	_
33	may	may	AUX	MD	VerbForm=Fin	_	_	_	_
34	operate	operate	VERB	VB	VerbForm=Inf	_	_	_	_
35	through	through	ADP	IN	_	_	_	_	_
36	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
37	of	of	ADP	IN	_	_	_	_	_
38	adenylate	adenylate	ADJ	JJ	Degree=Pos	_	_	_	_
39	cyclase	cyclase	NOUN	NN	Number=Sing	_	_	_	_
40	and	and	CCONJ	CC	_	_	_	_	_
41	pertussis-	pertussis-	SYM	NFP	_	_	_	_	SpaceAfter=No
42	toxin	toxin	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
43	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
44	sensitive	sensitive	ADJ	JJ	Degree=Pos	_	_	_	_
45	Gi	gi	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
46	/	/	PUNCT	,	_	_	_	_	SpaceAfter=No
47	Go	go	PROPN	NNP	Number=Sing	_	_	_	_
48	protein	protein	NOUN	NN	Number=Sing	_	_	_	_
49	to	to	ADP	IN	_	_	_	_	_
50	effect	effect	NOUN	NN	Number=Sing	_	_	_	_
51	p70	p70	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
52	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
53	S6	S6	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
54	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
55	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
56	kinase	kinase	NOUN	NN	Number=Sing	_	_	_	_
57	activation	activation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
58	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 1082
# text = Document 003002383 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	003002383	003002383	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 1083
# text = Role of IKK1 and IKK2 in lipopolysaccharide signaling in human monocytic cells.
1	Role	role	NOUN	NN	Number=Sing	_	_	_	_
2	of	of	ADP	IN	_	_	_	_	_
3	IKK1	IKK1	NUM	CD	NumType=Card	_	_	_	_
4	and	and	CCONJ	CC	_	_	_	_	_
5	IKK2	IKK2	NUM	CD	NumType=Card	_	_	_	_
6	in	in	ADP	IN	_	_	_	_	_
7	lipopolysaccharide	lipopolysaccharide	NOUN	NN	Number=Sing	_	_	_	_
8	signaling	signaling	NOUN	NN	Number=Sing	_	_	_	_
9	in	in	ADP	IN	_	_	_	_	_
10	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
11	monocytic	monocytic	ADJ	JJ	Degree=Pos	_	_	_	_
12	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
13	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 1084
# text = Mononuclear phagocytes play a major role in immune and inflammatory responses.
1	Mononuclear	Mononuclear	ADJ	JJ	Degree=Pos	_	_	_	_
2	phagocytes	phagocyte	NOUN	NNS	Number=Plur	_	_	_	_
3	play	play	VERB	VB	VerbForm=Inf	_	_	_	_
4	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
5	major	major	ADJ	JJ	Degree=Pos	_	_	_	_
6	role	role	NOUN	NN	Number=Sing	_	_	_	_
7	in	in	ADP	IN	_	_	_	_	_
8	immune	immune	ADJ	JJ	Degree=Pos	_	_	_	_
9	and	and	CCONJ	CC	_	_	_	_	_
10	inflammatory	inflammatory	ADJ	JJ	Degree=Pos	_	_	_	_
11	responses	response	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
12	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1085
# text = Bacterial lipopolysaccharide (LPS) induces monocytes to express a variety of genes by activating the NF-kappaB/Rel transcription factor family.
1	Bacterial	Bacterial	ADJ	JJ	Degree=Pos	_	_	_	_
2	lipopolysaccharide	lipopolysaccharide	NOUN	NN	Number=Sing	_	_	_	_
3	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
4	LPS	LPS	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
5	)	)	PUNCT	-RRB-	_	_	_	_	_
6	induces	induce	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
7	monocytes	monocyte	NOUN	NNS	Number=Plur	_	_	_	_
8	to	to	PART	TO	_	_	_	_	_
9	express	express	VERB	VB	VerbForm=Inf	_	_	_	_
10	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
11	variety	variety	NOUN	NN	Number=Sing	_	_	_	_
12	of	of	ADP	IN	_	_	_	_	_
13	genes	gene	NOUN	NNS	Number=Plur	_	_	_	_
14	by	by	SCONJ	IN	_	_	_	_	_
15	activating	activat	VERB	VBG	VerbForm=Ger	_	_	_	_
16	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
17	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
18	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
19	kappaB	kappaB	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
20	/	/	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
21	Rel	Rel	PROPN	NNP	Number=Sing	_	_	_	_
22	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
23	factor	factor	NOUN	NN	Number=Sing	_	_	_	_
24	family	family	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
25	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1086
# text = Recently, we have reported that the tumor necrosis factor and interleukin 1 signaling pathways activate two kinases, IKK1 and IKK2.
1	Recently	recently	ADV	RB	_	_	_	_	SpaceAfter=No
2	,	,	PUNCT	,	_	_	_	_	_
3	we	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
4	have	have	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
5	reported	report	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
6	that	that	SCONJ	IN	_	_	_	_	_
7	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
8	tumor	tumor	NOUN	NN	Number=Sing	_	_	_	_
9	necrosis	necrosis	NOUN	NN	Number=Sing	_	_	_	_
10	factor	factor	NOUN	NN	Number=Sing	_	_	_	_
11	and	and	CCONJ	CC	_	_	_	_	_
12	interleukin	interleukin	ADJ	JJ	Degree=Pos	_	_	_	_
13	1	1	NUM	CD	NumType=Card	_	_	_	_
14	signaling	signaling	NOUN	NN	Number=Sing	_	_	_	_
15	pathways	pathway	NOUN	NNS	Number=Plur	_	_	_	_
16	activate	activate	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
17	two	two	NUM	CD	NumType=Card	_	_	_	_
18	kinases	kinase	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
19	,	,	PUNCT	,	_	_	_	_	_
20	IKK1	IKK1	NUM	CD	NumType=Card	_	_	_	_
21	and	and	CCONJ	CC	_	_	_	_	_
22	IKK2	IKK2	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
23	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1087
# text = Phosphorylation of the IkappaB cytoplasmic inhibitors, IkappaBalpha, IkappaBbeta, and IkappaBepsilon, by these kinases triggers proteolytic degradation and the release of NF-kappaB/Rel proteins into the nucleus.
1	Phosphorylation	Phosphorylation	NOUN	NN	Number=Sing	_	_	_	_
2	of	of	ADP	IN	_	_	_	_	_
3	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
4	IkappaB	IkappaB	PROPN	NNP	Number=Sing	_	_	_	_
5	cytoplasmic	cytoplasmic	ADJ	JJ	Degree=Pos	_	_	_	_
6	inhibitors	inhibitor	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
7	,	,	PUNCT	,	_	_	_	_	_
8	IkappaBalpha	IkappaBalpha	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
9	,	,	PUNCT	,	_	_	_	_	_
10	IkappaBbeta	IkappaBbeta	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
11	,	,	PUNCT	,	_	_	_	_	_
12	and	and	CCONJ	CC	_	_	_	_	_
13	IkappaBepsilon	IkappaBepsilon	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
14	,	,	PUNCT	,	_	_	_	_	_
15	by	by	ADP	IN	_	_	_	_	_
16	these	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
17	kinases	kinase	NOUN	NNS	Number=Plur	_	_	_	_
18	triggers	trigger	NOUN	NNS	Number=Plur	_	_	_	_
19	proteolytic	proteolytic	ADJ	JJ	Degree=Pos	_	_	_	_
20	degradation	degradation	NOUN	NN	Number=Sing	_	_	_	_
21	and	and	CCONJ	CC	_	_	_	_	_
22	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
23	release	release	NOUN	NN	Number=Sing	_	_	_	_
24	of	of	ADP	IN	_	_	_	_	_
25	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
26	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
27	kappaB	kappaB	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
28	/	/	PUNCT	,	_	_	_	_	SpaceAfter=No
29	Rel	Rel	PROPN	NNP	Number=Sing	_	_	_	_
30	proteins	protein	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
31	into	into	ADP	IN	_	_	_	_	_
32	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
33	nucleus	nucleus	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
34	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1088
# text = At present, the role of the IKKs in LPS signaling has not been investigated.
1	At	at	ADP	IN	_	_	_	_	_
2	present	present	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
3	,	,	PUNCT	,	_	_	_	_	_
4	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
5	role	role	NOUN	NN	Number=Sing	_	_	_	_
6	of	of	ADP	IN	_	_	_	_	_
7	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
8	IKKs	IKKs	PROPN	NNPS	Number=Plur	_	_	_	_
9	in	in	ADP	IN	_	_	_	_	_
10	LPS	LPS	PROPN	NNP	Number=Sing	_	_	_	_
11	signaling	signaling	NOUN	NN	Number=Sing	_	_	_	_
12	has	have	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
13	not	not	PART	RB	_	_	_	_	_
14	been	be	AUX	VBN	Tense=Past|VerbForm=Part	_	_	_	_
15	investigated	investigate	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	SpaceAfter=No
16	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1089
# text = Here, we report that LPS induces IKK activity in human monocytes and THP-1 monocytic cells.
1	Here	here	ADV	RB	PronType=Dem	_	_	_	SpaceAfter=No
2	,	,	PUNCT	,	_	_	_	_	_
3	we	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
4	report	report	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
5	that	that	SCONJ	IN	_	_	_	_	_
6	LPS	LPS	PROPN	NNP	Number=Sing	_	_	_	_
7	induces	induce	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
8	IKK	Ikk	NUM	CD	NumType=Card	_	_	_	_
9	activity	activity	NOUN	NN	Number=Sing	_	_	_	_
10	in	in	ADP	IN	_	_	_	_	_
11	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
12	monocytes	monocyte	NOUN	NNS	Number=Plur	_	_	_	_
13	and	and	CCONJ	CC	_	_	_	_	_
14	THP	Thp	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
15	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
16	1	1	NUM	CD	NumType=Card	_	_	_	_
17	monocytic	monocytic	ADJ	JJ	Degree=Pos	_	_	_	_
18	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
19	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1090
# text = The kinetics of activation of kinase activity in monocytic cells are relatively slow with maximal activity observed at 60 min, which coincides with the degradation of IkappaBs and the nuclear translocation of NF-kappaB.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	kinetics	kinetic	NOUN	NNS	Number=Plur	_	_	_	_
3	of	of	ADP	IN	_	_	_	_	_
4	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
5	of	of	ADP	IN	_	_	_	_	_
6	kinase	kinase	NOUN	NN	Number=Sing	_	_	_	_
7	activity	activity	NOUN	NN	Number=Sing	_	_	_	_
8	in	in	ADP	IN	_	_	_	_	_
9	monocytic	monocytic	ADJ	JJ	Degree=Pos	_	_	_	_
10	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
11	are	be	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
12	relatively	relatively	ADV	RB	_	_	_	_	_
13	slow	slow	ADJ	JJ	Degree=Pos	_	_	_	_
14	with	with	ADP	IN	_	_	_	_	_
15	maximal	maximal	ADJ	JJ	Degree=Pos	_	_	_	_
16	activity	activity	NOUN	NN	Number=Sing	_	_	_	_
17	observed	observe	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
18	at	at	ADP	IN	_	_	_	_	_
19	60	60	NUM	CD	NumType=Card	_	_	_	_
20	min	min	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
21	,	,	PUNCT	,	_	_	_	_	_
22	which	which	PRON	WDT	PronType=Rel	_	_	_	_
23	coincides	coincide	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
24	with	with	ADP	IN	_	_	_	_	_
25	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
26	degradation	degradation	NOUN	NN	Number=Sing	_	_	_	_
27	of	of	ADP	IN	_	_	_	_	_
28	IkappaBs	IkappaB	NOUN	NNS	Number=Plur	_	_	_	_
29	and	and	CCONJ	CC	_	_	_	_	_
30	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
31	nuclear	nuclear	ADJ	JJ	Degree=Pos	_	_	_	_
32	translocation	translocation	NOUN	NN	Number=Sing	_	_	_	_
33	of	of	ADP	IN	_	_	_	_	_
34	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
35	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
36	kappaB	kappaB	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
37	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1091
# text = In transfection experiments, overexpression of wild type IKK1, a dominant negative mutant IKK1 (K44M), or wild type IKK2 did not affect LPS-induced kappaB-dependent transcription in monocytic cells.
1	In	in	ADP	IN	_	_	_	_	_
2	transfection	transfection	NOUN	NN	Number=Sing	_	_	_	_
3	experiments	experiment	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	,	,	PUNCT	,	_	_	_	_	_
5	overexpression	overexpression	NOUN	NN	Number=Sing	_	_	_	_
6	of	of	ADP	IN	_	_	_	_	_
7	wild	wild	NOUN	NN	Number=Sing	_	_	_	_
8	type	type	NOUN	NN	Number=Sing	_	_	_	_
9	IKK1	Ikk1	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
10	,	,	PUNCT	,	_	_	_	_	_
11	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
12	dominant	dominant	ADJ	JJ	Degree=Pos	_	_	_	_
13	negative	negative	ADJ	JJ	Degree=Pos	_	_	_	_
14	mutant	mutant	NOUN	NN	Number=Sing	_	_	_	_
15	IKK1	Ikk1	PROPN	NNP	Number=Sing	_	_	_	_
16	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
17	K44	K44	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
18	M	m	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
19	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
20	,	,	PUNCT	,	_	_	_	_	_
21	or	or	CCONJ	CC	_	_	_	_	_
22	wild	wild	AUX	MD	VerbForm=Fin	_	_	_	_
23	type	type	VERB	VB	VerbForm=Inf	_	_	_	_
24	IKK2	IKK2	NUM	CD	NumType=Card	_	_	_	_
25	did	do	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
26	not	not	PART	RB	_	_	_	_	_
27	affect	affect	VERB	VB	VerbForm=Inf	_	_	_	_
28	LPS	Lps	ADV	RB	_	_	_	_	SpaceAfter=No
29	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
30	induced	induce	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
31	kappaB	kappab	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
32	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
33	dependent	dependent	ADJ	JJ	Degree=Pos	_	_	_	_
34	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
35	in	in	ADP	IN	_	_	_	_	_
36	monocytic	monocytic	ADJ	JJ	Degree=Pos	_	_	_	_
37	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
38	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1092
# text = In contrast, a dominant negative mutant of IKK2 inhibited LPS induction of kappaB-dependent transcription in a dose-dependent manner.
1	In	in	ADP	IN	_	_	_	_	_
2	contrast	contrast	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
3	,	,	PUNCT	,	_	_	_	_	_
4	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
5	dominant	dominant	ADJ	JJ	Degree=Pos	_	_	_	_
6	negative	negative	ADJ	JJ	Degree=Pos	_	_	_	_
7	mutant	mutant	NOUN	NN	Number=Sing	_	_	_	_
8	of	of	ADP	IN	_	_	_	_	_
9	IKK2	IKK2	NUM	CD	NumType=Card	_	_	_	_
10	inhibited	inhibit	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
11	LPS	Lps	ADJ	JJ	Degree=Pos	_	_	_	_
12	induction	induction	NOUN	NN	Number=Sing	_	_	_	_
13	of	of	ADP	IN	_	_	_	_	_
14	kappaB	kappaB	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
15	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
16	dependent	dependent	ADJ	JJ	Degree=Pos	_	_	_	_
17	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
18	in	in	ADP	IN	_	_	_	_	_
19	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
20	dose	dose	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
21	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
22	dependent	dependent	ADJ	JJ	Degree=Pos	_	_	_	_
23	manner	manner	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
24	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1093
# text = These results indicate that LPS induction of kappaB-dependent gene expression in human monocytic cells requires activation of IKK2.
1	These	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
2	results	result	NOUN	NNS	Number=Plur	_	_	_	_
3	indicate	indicate	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
4	that	that	SCONJ	IN	_	_	_	_	_
5	LPS	LPS	PROPN	NNP	Number=Sing	_	_	_	_
6	induction	induction	NOUN	NN	Number=Sing	_	_	_	_
7	of	of	ADP	IN	_	_	_	_	_
8	kappaB	kappaB	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
9	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
10	dependent	dependent	ADJ	JJ	Degree=Pos	_	_	_	_
11	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
12	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
13	in	in	ADP	IN	_	_	_	_	_
14	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
15	monocytic	monocytic	ADJ	JJ	Degree=Pos	_	_	_	_
16	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
17	requires	require	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
18	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
19	of	of	ADP	IN	_	_	_	_	_
20	IKK2	IKK2	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
21	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 1094
# text = Document 003002388 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	003002388	003002388	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 1095
# text = GABP factors bind to a distal interleukin 2 (IL-2) enhancer and contribute to c-Raf-mediated increase in IL-2 induction.
1	GABP	GABp	SYM	NFP	_	_	_	_	_
2	factors	factor	NOUN	NNS	Number=Plur	_	_	_	_
3	bind	bind	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
4	to	to	ADP	IN	_	_	_	_	_
5	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
6	distal	distal	ADJ	JJ	Degree=Pos	_	_	_	_
7	interleukin	interleukin	NOUN	NN	Number=Sing	_	_	_	_
8	2	2	NUM	CD	NumType=Card	_	_	_	_
9	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
10	IL	Il	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
11	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
12	2	2	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
13	)	)	PUNCT	-RRB-	_	_	_	_	_
14	enhancer	enhancer	NOUN	NN	Number=Sing	_	_	_	_
15	and	and	CCONJ	CC	_	_	_	_	_
16	contribute	contribute	NOUN	NN	Number=Sing	_	_	_	_
17	to	to	ADP	IN	_	_	_	_	_
18	c	c	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
19	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
20	Raf	Raf	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
21	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
22	mediated	mediate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
23	increase	increase	NOUN	NN	Number=Sing	_	_	_	_
24	in	in	ADP	IN	_	_	_	_	_
25	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
26	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
27	2	2	NUM	CD	NumType=Card	_	_	_	_
28	induction	induction	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
29	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 1096
# text = Triggering of the T-cell receptor-CD3 complex activates two major signal cascades in T lymphocytes, (i) Ca2+-dependent signal cascades and (ii) protein kinase cascades.
1	Triggering	Triggering	ADP	IN	_	_	_	_	_
2	of	of	ADP	IN	_	_	_	_	_
3	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
4	T-	t-	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
5	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
6	receptor	receptor	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
7	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
8	CD3	CD3	NOUN	NN	Number=Sing	_	_	_	_
9	complex	complex	NOUN	NN	Number=Sing	_	_	_	_
10	activates	activate	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
11	two	two	NUM	CD	NumType=Card	_	_	_	_
12	major	major	ADJ	JJ	Degree=Pos	_	_	_	_
13	signal	signal	NOUN	NN	Number=Sing	_	_	_	_
14	cascades	cascade	NOUN	NNS	Number=Plur	_	_	_	_
15	in	in	ADP	IN	_	_	_	_	_
16	T	t	PROPN	NNP	Number=Sing	_	_	_	_
17	lymphocytes	lymphocyte	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
18	,	,	PUNCT	,	_	_	_	_	_
19	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
20	i	i	X	LS	_	_	_	_	SpaceAfter=No
21	)	)	PUNCT	-RRB-	_	_	_	_	_
22	Ca2+-	Ca2+-	SYM	SYM	_	_	_	_	SpaceAfter=No
23	dependent	dependent	ADJ	JJ	Degree=Pos	_	_	_	_
24	signal	signal	NOUN	NN	Number=Sing	_	_	_	_
25	cascades	cascade	NOUN	NNS	Number=Plur	_	_	_	_
26	and	and	CCONJ	CC	_	_	_	_	_
27	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
28	ii	ii	X	LS	_	_	_	_	SpaceAfter=No
29	)	)	PUNCT	-RRB-	_	_	_	_	_
30	protein	protein	NOUN	NN	Number=Sing	_	_	_	_
31	kinase	kinase	NOUN	NN	Number=Sing	_	_	_	_
32	cascades	cascade	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
33	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1097
# text = Both signal cascades contribute to the induction of the interleukin 2 (IL-2) gene during T-cell activation.
1	Both	both	DET	DT	_	_	_	_	_
2	signal	signal	NOUN	NN	Number=Sing	_	_	_	_
3	cascades	cascade	NOUN	NNS	Number=Plur	_	_	_	_
4	contribute	contribute	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
5	to	to	ADP	IN	_	_	_	_	_
6	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
7	induction	induction	NOUN	NN	Number=Sing	_	_	_	_
8	of	of	ADP	IN	_	_	_	_	_
9	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
10	interleukin	interleukin	NOUN	NN	Number=Sing	_	_	_	_
11	2	2	NUM	CD	NumType=Card	_	_	_	_
12	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
13	IL	Il	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
14	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
15	2	2	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
16	)	)	PUNCT	-RRB-	_	_	_	_	_
17	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
18	during	during	ADP	IN	_	_	_	_	_
19	T-	t-	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
20	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
21	activation	activation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
22	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1098
# text = Prominent protein kinase cascades are those that activate mitogen-activated protein (MAP) kinases.
1	Prominent	prominent	ADJ	JJ	Degree=Pos	_	_	_	_
2	protein	protein	NOUN	NN	Number=Sing	_	_	_	_
3	kinase	kinase	NOUN	NN	Number=Sing	_	_	_	_
4	cascades	cascade	NOUN	NNS	Number=Plur	_	_	_	_
5	are	be	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
6	those	those	PRON	DT	Number=Plur|PronType=Dem	_	_	_	_
7	that	that	PRON	WDT	PronType=Rel	_	_	_	_
8	activate	activate	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
9	mitogen	mitogen	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
10	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
11	activated	activated	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
12	protein	protein	NOUN	NN	Number=Sing	_	_	_	_
13	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
14	MAP	map	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
15	)	)	PUNCT	-RRB-	_	_	_	_	_
16	kinases	kinase	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
17	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1099
# text = We show here that c-Raf, which is at the helm of the classic MAP-Erk cascade, contributes to IL-2 induction through a distal enhancer element spanning the nucleotides from positions -502 to -413 in front of the transcriptional start site of the IL-2 gene.
1	We	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
2	show	show	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
3	here	here	ADV	RB	PronType=Dem	_	_	_	_
4	that	that	SCONJ	IN	_	_	_	_	_
5	c	c	NOUN	NN	Abbr=Yes|Number=Sing	_	_	_	SpaceAfter=No
6	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
7	Raf	Raf	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
8	,	,	PUNCT	,	_	_	_	_	_
9	which	which	PRON	WDT	PronType=Rel	_	_	_	_
10	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
11	at	at	ADP	IN	_	_	_	_	_
12	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
13	helm	helm	NOUN	NN	Number=Sing	_	_	_	_
14	of	of	ADP	IN	_	_	_	_	_
15	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
16	classic	classic	ADJ	JJ	Degree=Pos	_	_	_	_
17	MAP	map	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
18	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
19	Erk	Erk	PROPN	NNP	Number=Sing	_	_	_	_
20	cascade	cascade	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
21	,	,	PUNCT	,	_	_	_	_	_
22	contributes	contribute	NOUN	NNS	Number=Plur	_	_	_	_
23	to	to	ADP	IN	_	_	_	_	_
24	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
25	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
26	2	2	NUM	CD	NumType=Card	_	_	_	_
27	induction	induction	NOUN	NN	Number=Sing	_	_	_	_
28	through	through	ADP	IN	_	_	_	_	_
29	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
30	distal	distal	ADJ	JJ	Degree=Pos	_	_	_	_
31	enhancer	enhancer	NOUN	NN	Number=Sing	_	_	_	_
32	element	element	NOUN	NN	Number=Sing	_	_	_	_
33	spanning	spann	VERB	VBG	VerbForm=Ger	_	_	_	_
34	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
35	nucleotides	nucleotide	NOUN	NNS	Number=Plur	_	_	_	_
36	from	from	ADP	IN	_	_	_	_	_
37	positions	position	NOUN	NNS	Number=Plur	_	_	_	_
38	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
39	502	502	NUM	CD	NumType=Card	_	_	_	_
40	to	to	ADP	IN	_	_	_	_	_
41	-	-	SYM	SYM	_	_	_	_	SpaceAfter=No
42	413	413	NUM	CD	NumType=Card	_	_	_	_
43	in	in	ADP	IN	_	_	_	_	_
44	front	front	NOUN	NN	Number=Sing	_	_	_	_
45	of	of	ADP	IN	_	_	_	_	_
46	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
47	transcriptional	transcriptional	ADJ	JJ	Degree=Pos	_	_	_	_
48	start	start	NOUN	NN	Number=Sing	_	_	_	_
49	site	site	NOUN	NN	Number=Sing	_	_	_	_
50	of	of	ADP	IN	_	_	_	_	_
51	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
52	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
53	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
54	2	2	NUM	CD	NumType=Card	_	_	_	_
55	gene	gene	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
56	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1100
# text = Induction of this distal IL-2 enhancer differs from induction of the proximal IL-2 promoter-enhancer, since it is induced by phorbol esters alone and independent from Ca2+ signals.
1	Induction	Induction	NOUN	NN	Number=Sing	_	_	_	_
2	of	of	ADP	IN	_	_	_	_	_
3	this	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
4	distal	distal	ADJ	JJ	Degree=Pos	_	_	_	_
5	IL	Il	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
6	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
7	2	2	NUM	CD	NumType=Card	_	_	_	_
8	enhancer	enhancer	NOUN	NN	Number=Sing	_	_	_	_
9	differs	differ	NOUN	NNS	Number=Plur	_	_	_	_
10	from	from	ADP	IN	_	_	_	_	_
11	induction	induction	NOUN	NN	Number=Sing	_	_	_	_
12	of	of	ADP	IN	_	_	_	_	_
13	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
14	proximal	proximal	ADJ	JJ	Degree=Pos	_	_	_	_
15	IL	Il	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
16	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
17	2	2	NUM	CD	NumType=Card	_	_	_	_
18	promoter	promoter	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
19	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
20	enhancer	enhancer	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
21	,	,	PUNCT	,	_	_	_	_	_
22	since	since	SCONJ	IN	_	_	_	_	_
23	it	it	PRON	PRP	Case=Nom|Gender=Neut|Number=Sing|Person=3|PronType=Prs	_	_	_	_
24	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
25	induced	induce	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
26	by	by	ADP	IN	_	_	_	_	_
27	phorbol	phorbol	NOUN	NN	Number=Sing	_	_	_	_
28	esters	ester	NOUN	NNS	Number=Plur	_	_	_	_
29	alone	alone	ADJ	JJ	Degree=Pos	_	_	_	_
30	and	and	CCONJ	CC	_	_	_	_	_
31	independent	independent	ADJ	JJ	Degree=Pos	_	_	_	_
32	from	from	ADP	IN	_	_	_	_	_
33	Ca2	Ca2	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
34	+	+	SYM	SYM	_	_	_	_	_
35	signals	signal	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
36	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1101
# text = In DNA-protein binding studies, we detected the binding of transcription factors GABP alpha and -beta to a dyad symmetry element (DSE) of the distal enhancer, which is formed by palindromic binding sites of Ets-like factors.
1	In	in	ADP	IN	_	_	_	_	_
2	DNA	dna	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
3	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
4	protein	protein	NOUN	NN	Number=Sing	_	_	_	_
5	binding	binding	VERB	VBG	VerbForm=Ger	_	_	_	_
6	studies	study	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
7	,	,	PUNCT	,	_	_	_	_	_
8	we	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
9	detected	detect	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
10	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
11	binding	binding	NOUN	NN	Number=Sing	_	_	_	_
12	of	of	ADP	IN	_	_	_	_	_
13	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
14	factors	factor	NOUN	NNS	Number=Plur	_	_	_	_
15	GABP	GABP	PROPN	NNP	Number=Sing	_	_	_	_
16	alpha	alpha	PROPN	NNP	Number=Sing	_	_	_	_
17	and	and	CCONJ	CC	_	_	_	_	_
18	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
19	beta	beta	NOUN	NN	Number=Sing	_	_	_	_
20	to	to	ADP	IN	_	_	_	_	_
21	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
22	dyad	dyad	NOUN	NN	Number=Sing	_	_	_	_
23	symmetry	symmetry	NOUN	NN	Number=Sing	_	_	_	_
24	element	element	NOUN	NN	Number=Sing	_	_	_	_
25	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
26	DSE	DSE	INTJ	UH	_	_	_	_	SpaceAfter=No
27	)	)	PUNCT	-RRB-	_	_	_	_	_
28	of	of	ADP	IN	_	_	_	_	_
29	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
30	distal	distal	ADJ	JJ	Degree=Pos	_	_	_	_
31	enhancer	enhancer	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
32	,	,	PUNCT	,	_	_	_	_	_
33	which	which	PRON	WDT	PronType=Rel	_	_	_	_
34	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
35	formed	form	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
36	by	by	ADP	IN	_	_	_	_	_
37	palindromic	palindromic	ADJ	JJ	Degree=Pos	_	_	_	_
38	binding	binding	VERB	VBG	VerbForm=Ger	_	_	_	_
39	sites	site	NOUN	NNS	Number=Plur	_	_	_	_
40	of	of	ADP	IN	_	_	_	_	_
41	Ets	Ets	PROPN	NNPS	Number=Plur	_	_	_	SpaceAfter=No
42	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
43	like	like	ADJ	JJ	Degree=Pos	_	_	_	_
44	factors	factor	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
45	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1102
# text = Introduction of point mutations suppressing GABP binding to the DSE interfered with the induction of the distal enhancer and the entire IL-2 promoter-enhancer, while overexpression of both GABP factors enhanced the IL-2 promoter-enhancer induction.
1	Introduction	introduction	NOUN	NN	Number=Sing	_	_	_	_
2	of	of	ADP	IN	_	_	_	_	_
3	point	point	NOUN	NN	Number=Sing	_	_	_	_
4	mutations	mutation	NOUN	NNS	Number=Plur	_	_	_	_
5	suppressing	suppresse	VERB	VBG	VerbForm=Ger	_	_	_	_
6	GABP	GABP	PROPN	NNP	Number=Sing	_	_	_	_
7	binding	bind	VERB	VBG	VerbForm=Ger	_	_	_	_
8	to	to	ADP	IN	_	_	_	_	_
9	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
10	DSE	DSE	PROPN	NNP	Number=Sing	_	_	_	_
11	interfered	interfer	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
12	with	with	ADP	IN	_	_	_	_	_
13	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
14	induction	induction	NOUN	NN	Number=Sing	_	_	_	_
15	of	of	ADP	IN	_	_	_	_	_
16	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
17	distal	distal	ADJ	JJ	Degree=Pos	_	_	_	_
18	enhancer	enhancer	NOUN	NN	Number=Sing	_	_	_	_
19	and	and	CCONJ	CC	_	_	_	_	_
20	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
21	entire	entire	ADJ	JJ	Degree=Pos	_	_	_	_
22	IL	Il	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
23	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
24	2	2	NUM	CD	NumType=Card	_	_	_	_
25	promoter	promoter	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
26	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
27	enhancer	enhancer	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
28	,	,	PUNCT	,	_	_	_	_	_
29	while	while	SCONJ	IN	_	_	_	_	_
30	overexpression	overexpression	NOUN	NN	Number=Sing	_	_	_	_
31	of	of	ADP	IN	_	_	_	_	_
32	both	both	DET	DT	_	_	_	_	_
33	GABP	GABP	NOUN	NN	Number=Sing	_	_	_	_
34	factors	factor	NOUN	NNS	Number=Plur	_	_	_	_
35	enhanced	enhance	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
36	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
37	IL	Il	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
38	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
39	2	2	NUM	CD	NumType=Card	_	_	_	_
40	promoter	promoter	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
41	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
42	enhancer	enhancer	NOUN	NN	Number=Sing	_	_	_	_
43	induction	induction	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
44	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1103
# text = Overexpression of BXB, a constitutive active version of c-Raf, and of further members of the Ras-Raf-Erk signal cascade exerted an increase of GABP-mediated promoter-enhancer induction.
1	Overexpression	Overexpression	NOUN	NN	Number=Sing	_	_	_	_
2	of	of	ADP	IN	_	_	_	_	_
3	BXB	BXB	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
4	,	,	PUNCT	,	_	_	_	_	_
5	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
6	constitutive	constitutive	ADJ	JJ	Degree=Pos	_	_	_	_
7	active	active	ADJ	JJ	Degree=Pos	_	_	_	_
8	version	version	NOUN	NN	Number=Sing	_	_	_	_
9	of	of	ADP	IN	_	_	_	_	_
10	c	c	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
11	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
12	Raf	Raf	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
13	,	,	PUNCT	,	_	_	_	_	_
14	and	and	CCONJ	CC	_	_	_	_	_
15	of	of	ADP	IN	_	_	_	_	_
16	further	further	ADJ	JJ	Degree=Pos	_	_	_	_
17	members	member	NOUN	NNS	Number=Plur	_	_	_	_
18	of	of	ADP	IN	_	_	_	_	_
19	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
20	Ras	Ras	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
21	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
22	Raf	Raf	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
23	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
24	Erk	Erk	PROPN	NNP	Number=Sing	_	_	_	_
25	signal	signal	NOUN	NN	Number=Sing	_	_	_	_
26	cascade	cascade	NOUN	NN	Number=Sing	_	_	_	_
27	exerted	exert	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
28	an	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
29	increase	increase	NOUN	NN	Number=Sing	_	_	_	_
30	of	of	ADP	IN	_	_	_	_	_
31	GABP	GABP	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
32	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
33	mediated	mediate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
34	promoter	promoter	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
35	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
36	enhancer	enhancer	NOUN	NN	Number=Sing	_	_	_	_
37	induction	induction	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
38	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1104
# text = In conjunction with previously published data on c-Raf-induced phosphorylation of GABP factors (E.Flory, A.
1	In	in	ADP	IN	_	_	_	_	_
2	conjunction	conjunction	NOUN	NN	Number=Sing	_	_	_	_
3	with	with	ADP	IN	_	_	_	_	_
4	previously	previously	ADV	RB	_	_	_	_	_
5	published	publish	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
6	data	data	NOUN	NN	Number=Sing	_	_	_	_
7	on	on	ADP	IN	_	_	_	_	_
8	c	c	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
9	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
10	Raf	Raf	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
11	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
12	induced	induce	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
13	phosphorylation	phosphorylation	NOUN	NN	Number=Sing	_	_	_	_
14	of	of	ADP	IN	_	_	_	_	_
15	GABP	GABP	PROPN	NNP	Number=Sing	_	_	_	_
16	factors	factor	NOUN	NNS	Number=Plur	_	_	_	_
17	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
18	E.Flory	E.Flory	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
19	,	,	PUNCT	,	_	_	_	_	_
20	A	A	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
21	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1105
# text = Hoffmeyer, U.Smola, U.R.Rapp, and J.T.Bruder, J.Virol.70:2260- 2268, 1996), these results indicate a contribution of GABP factors to the Raf-mediated enhancement of IL-2 induction during T-cell activation.
1	Hoffmeyer	Hoffmeyer	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
2	,	,	PUNCT	,	_	_	_	_	_
3	U.Smola	U.Smola	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
4	,	,	PUNCT	,	_	_	_	_	_
5	U.R.Rapp	U.R.Rapp	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
6	,	,	PUNCT	,	_	_	_	_	_
7	and	and	CCONJ	CC	_	_	_	_	_
8	J.T.Bruder	J.T.Bruder	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
9	,	,	PUNCT	,	_	_	_	_	_
10	J.Virol	J.Virol	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
11	.70:2260	.70:2260	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
12	-	-	SYM	SYM	_	_	_	_	_
13	2268	2268	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
14	,	,	PUNCT	,	_	_	_	_	_
15	1996	1996	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
16	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
17	,	,	PUNCT	,	_	_	_	_	_
18	these	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
19	results	result	NOUN	NNS	Number=Plur	_	_	_	_
20	indicate	indicate	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
21	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
22	contribution	contribution	NOUN	NN	Number=Sing	_	_	_	_
23	of	of	ADP	IN	_	_	_	_	_
24	GABP	Gabp	NOUN	NN	Number=Sing	_	_	_	_
25	factors	factor	NOUN	NNS	Number=Plur	_	_	_	_
26	to	to	ADP	IN	_	_	_	_	_
27	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
28	Raf	Raf	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
29	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
30	mediated	mediate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
31	enhancement	enhancement	NOUN	NN	Number=Sing	_	_	_	_
32	of	of	ADP	IN	_	_	_	_	_
33	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
34	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
35	2	2	NUM	CD	NumType=Card	_	_	_	_
36	induction	induction	NOUN	NN	Number=Sing	_	_	_	_
37	during	during	ADP	IN	_	_	_	_	_
38	T-	t-	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
39	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
40	activation	activation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
41	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 1106
# text = Document 003002389 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	003002389	003002389	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 1107
# text = Characterization of a cofactor that regulates dimerization of a mammalian homeodomain protein.
1	Characterization	Characterization	NOUN	NN	Number=Sing	_	_	_	_
2	of	of	ADP	IN	_	_	_	_	_
3	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
4	cofactor	cofactor	NOUN	NN	Number=Sing	_	_	_	_
5	that	that	PRON	WDT	PronType=Rel	_	_	_	_
6	regulates	regulate	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
7	dimerization	dimerization	NOUN	NN	Number=Sing	_	_	_	_
8	of	of	ADP	IN	_	_	_	_	_
9	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
10	mammalian	mammalian	ADJ	JJ	Degree=Pos	_	_	_	_
11	homeodomain	homeodomain	NOUN	NN	Number=Sing	_	_	_	_
12	protein	protein	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
13	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 1108
# text = Dimerization among transcription factors has become a recurrent theme in the regulation of eukaryotic gene expression.
1	Dimerization	Dimerization	NOUN	NN	Number=Sing	_	_	_	_
2	among	among	ADP	IN	_	_	_	_	_
3	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
4	factors	factor	NOUN	NNS	Number=Plur	_	_	_	_
5	has	have	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
6	become	become	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
7	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
8	recurrent	recurrent	ADJ	JJ	Degree=Pos	_	_	_	_
9	theme	theme	NOUN	NN	Number=Sing	_	_	_	_
10	in	in	ADP	IN	_	_	_	_	_
11	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
12	regulation	regulation	NOUN	NN	Number=Sing	_	_	_	_
13	of	of	ADP	IN	_	_	_	_	_
14	eukaryotic	eukaryotic	ADJ	JJ	Degree=Pos	_	_	_	_
15	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
16	expression	expression	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
17	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1109
# text = Hepatocyte nuclear factor-1 alpha (HNF-1 alpha) is a homeodomain-containing protein that functions as a dimer.
1	Hepatocyte	Hepatocyte	ADJ	JJ	Degree=Pos	_	_	_	_
2	nuclear	nuclear	ADJ	JJ	Degree=Pos	_	_	_	_
3	factor	factor	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
4	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
5	1	1	NUM	CD	NumType=Card	_	_	_	_
6	alpha	alpha	NOUN	NN	Number=Sing	_	_	_	_
7	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
8	HNF	HNF	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
9	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
10	1	1	NUM	CD	NumType=Card	_	_	_	_
11	alpha	alpha	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
12	)	)	PUNCT	-RRB-	_	_	_	_	_
13	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
14	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
15	homeodomain	homeodomain	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
16	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
17	containing	contain	VERB	VBG	VerbForm=Ger	_	_	_	_
18	protein	protein	NOUN	NN	Number=Sing	_	_	_	_
19	that	that	PRON	WDT	PronType=Rel	_	_	_	_
20	functions	function	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
21	as	as	ADP	IN	_	_	_	_	_
22	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
23	dimer	dimer	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
24	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1110
# text = A dimerization cofactor of HNF-1 alpha (DCoH) was identified that displayed a restricted tissue distribution and did not bind to DNA, but, rather, selectively stabilized HNF-1 alpha dimers.
1	A	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
2	dimerization	dimerization	NOUN	NN	Number=Sing	_	_	_	_
3	cofactor	cofactor	NOUN	NN	Number=Sing	_	_	_	_
4	of	of	ADP	IN	_	_	_	_	_
5	HNF	HNF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
6	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
7	1	1	NUM	CD	NumType=Card	_	_	_	_
8	alpha	alpha	NOUN	NN	Number=Sing	_	_	_	_
9	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
10	DCoH	DCoH	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
11	)	)	PUNCT	-RRB-	_	_	_	_	_
12	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
13	identified	identify	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
14	that	that	SCONJ	IN	_	_	_	_	_
15	displayed	display	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
16	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
17	restricted	restrict	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
18	tissue	tissue	NOUN	NN	Number=Sing	_	_	_	_
19	distribution	distribution	NOUN	NN	Number=Sing	_	_	_	_
20	and	and	CCONJ	CC	_	_	_	_	_
21	did	do	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
22	not	not	PART	RB	_	_	_	_	_
23	bind	bind	VERB	VB	VerbForm=Inf	_	_	_	_
24	to	to	ADP	IN	_	_	_	_	_
25	DNA	Dna	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
26	,	,	PUNCT	,	_	_	_	_	_
27	but	but	CCONJ	CC	_	_	_	_	SpaceAfter=No
28	,	,	PUNCT	,	_	_	_	_	_
29	rather	rather	ADV	RB	_	_	_	_	SpaceAfter=No
30	,	,	PUNCT	,	_	_	_	_	_
31	selectively	selectively	ADV	RB	_	_	_	_	_
32	stabilized	stabilize	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
33	HNF	HNF	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
34	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
35	1	1	NUM	CD	NumType=Card	_	_	_	_
36	alpha	alpha	NOUN	NN	Number=Sing	_	_	_	_
37	dimers	dimer	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
38	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1111
# text = The formation of a stable tetrameric DCoH-HNF-1 alpha complex, which required the dimerization domain of HNF-1 alpha, did not change the DNA binding characteristics of HNF-1 alpha, but enhanced its transcriptional activity.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	formation	formation	NOUN	NN	Number=Sing	_	_	_	_
3	of	of	ADP	IN	_	_	_	_	_
4	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
5	stable	stable	ADJ	JJ	Degree=Pos	_	_	_	_
6	tetrameric	tetrameric	NOUN	NN	Number=Sing	_	_	_	_
7	DCoH	DCoH	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
8	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
9	HNF	HNF	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
10	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
11	1	1	NUM	CD	NumType=Card	_	_	_	_
12	alpha	alpha	NOUN	NN	Number=Sing	_	_	_	_
13	complex	complex	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
14	,	,	PUNCT	,	_	_	_	_	_
15	which	which	PRON	WDT	PronType=Rel	_	_	_	_
16	required	require	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
17	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
18	dimerization	dimerization	NOUN	NN	Number=Sing	_	_	_	_
19	domain	domain	NOUN	NN	Number=Sing	_	_	_	_
20	of	of	ADP	IN	_	_	_	_	_
21	HNF	HNF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
22	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
23	1	1	NUM	CD	NumType=Card	_	_	_	_
24	alpha	alpha	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
25	,	,	PUNCT	,	_	_	_	_	_
26	did	do	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
27	not	not	PART	RB	_	_	_	_	_
28	change	change	VERB	VB	VerbForm=Inf	_	_	_	_
29	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
30	DNA	dna	NOUN	NN	Number=Sing	_	_	_	_
31	binding	bind	VERB	VBG	VerbForm=Ger	_	_	_	_
32	characteristics	characteristic	NOUN	NNS	Number=Plur	_	_	_	_
33	of	of	ADP	IN	_	_	_	_	_
34	HNF	HNF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
35	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
36	1	1	NUM	CD	NumType=Card	_	_	_	_
37	alpha	alpha	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
38	,	,	PUNCT	,	_	_	_	_	_
39	but	but	CCONJ	CC	_	_	_	_	_
40	enhanced	enhance	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
41	its	its	PRON	PRP$	Gender=Neut|Number=Sing|Person=3|Poss=Yes|PronType=Prs	_	_	_	_
42	transcriptional	transcriptional	ADJ	JJ	Degree=Pos	_	_	_	_
43	activity	activity	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
44	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1112
# text = However, DCoH did not confer transcriptional activation to the GAL4 DNA binding domain.
1	However	however	ADV	RB	_	_	_	_	SpaceAfter=No
2	,	,	PUNCT	,	_	_	_	_	_
3	DCoH	DCoH	PROPN	NNP	Number=Sing	_	_	_	_
4	did	do	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
5	not	not	PART	RB	_	_	_	_	_
6	confer	confer	VERB	VB	VerbForm=Inf	_	_	_	_
7	transcriptional	transcriptional	ADJ	JJ	Degree=Pos	_	_	_	_
8	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
9	to	to	ADP	IN	_	_	_	_	_
10	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
11	GAL4	Gal4	NOUN	NN	Number=Sing	_	_	_	_
12	DNA	dna	NOUN	NN	Number=Sing	_	_	_	_
13	binding	bind	VERB	VBG	VerbForm=Ger	_	_	_	_
14	domain	domain	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
15	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1113
# text = These results indicate that DCoH regulates formation of transcriptionally active tetrameric complexes and may contribute to the developmental specificity of the complex.
1	These	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
2	results	result	NOUN	NNS	Number=Plur	_	_	_	_
3	indicate	indicate	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
4	that	that	SCONJ	IN	_	_	_	_	_
5	DCoH	DCoH	PROPN	NNP	Number=Sing	_	_	_	_
6	regulates	regulate	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
7	formation	formation	NOUN	NN	Number=Sing	_	_	_	_
8	of	of	ADP	IN	_	_	_	_	_
9	transcriptionally	transcriptionally	ADV	RB	_	_	_	_	_
10	active	active	ADJ	JJ	Degree=Pos	_	_	_	_
11	tetrameric	tetrameric	ADJ	JJ	Degree=Pos	_	_	_	_
12	complexes	complex	NOUN	NNS	Number=Plur	_	_	_	_
13	and	and	CCONJ	CC	_	_	_	_	_
14	may	may	AUX	MD	VerbForm=Fin	_	_	_	_
15	contribute	contribute	VERB	VB	VerbForm=Inf	_	_	_	_
16	to	to	ADP	IN	_	_	_	_	_
17	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
18	developmental	developmental	ADJ	JJ	Degree=Pos	_	_	_	_
19	specificity	specificity	NOUN	NN	Number=Sing	_	_	_	_
20	of	of	ADP	IN	_	_	_	_	_
21	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
22	complex	complex	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
23	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 1114
# text = Document 003002390 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	003002390	003002390	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 1115
# text = Inhibitory effect of E3330, a novel quinone derivative able to suppress tumor necrosis factor-alpha generation, on activation of nuclear factor-kappa B. (2E)-3-[5-(2,3-Dimethoxy-6-methyl-1,4-benzoquinoyl)]-2-nonyl-2- propenoic acid (E3330), is a novel agent with hepatoprotective activity.
1	Inhibitory	Inhibitory	ADJ	JJ	Degree=Pos	_	_	_	_
2	effect	effect	NOUN	NN	Number=Sing	_	_	_	_
3	of	of	ADP	IN	_	_	_	_	_
4	E3330	E3330	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
5	,	,	PUNCT	,	_	_	_	_	_
6	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
7	novel	novel	NOUN	NN	Number=Sing	_	_	_	_
8	quinone	quinone	NOUN	NN	Number=Sing	_	_	_	_
9	derivative	derivative	NOUN	NN	Number=Sing	_	_	_	_
10	able	able	ADJ	JJ	Degree=Pos	_	_	_	_
11	to	to	PART	TO	_	_	_	_	_
12	suppress	suppress	VERB	VB	VerbForm=Inf	_	_	_	_
13	tumor	tumor	NOUN	NN	Number=Sing	_	_	_	_
14	necrosis	necrosis	NOUN	NN	Number=Sing	_	_	_	_
15	factor	factor	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
16	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
17	alpha	alpha	NOUN	NN	Number=Sing	_	_	_	_
18	generation	generation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
19	,	,	PUNCT	,	_	_	_	_	_
20	on	on	ADP	IN	_	_	_	_	_
21	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
22	of	of	ADP	IN	_	_	_	_	_
23	nuclear	nuclear	ADJ	JJ	Degree=Pos	_	_	_	_
24	factor-kappa	factor-kappa	NOUN	NN	Number=Sing	_	_	_	_
25	B.	B.	PROPN	NNP	Number=Sing	_	_	_	SpacesAfter=\s\n
26	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
27	2E	2E	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
28	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
29	-	-	PUNCT	:	_	_	_	_	SpaceAfter=No
30	3-[	3-[	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
31	5-(	5-(	SYM	NFP	_	_	_	_	SpaceAfter=No
32	2,3-Dimethoxy-6-methyl-1,4-benzoquinoyl)]-2-nonyl-2	2,3-Dimethoxy-6-methyl-1,4-benzoquinoyl)]-2-nonyl-2	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
33	-	-	SYM	SYM	_	_	_	_	_
34	propenoic	propenoic	ADJ	JJ	Degree=Pos	_	_	_	_
35	acid	acid	NOUN	NN	Number=Sing	_	_	_	_
36	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
37	E3330	E3330	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
38	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
39	,	,	PUNCT	,	_	_	_	_	_
40	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
41	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
42	novel	novel	NOUN	NN	Number=Sing	_	_	_	_
43	agent	agent	NOUN	NN	Number=Sing	_	_	_	_
44	with	with	ADP	IN	_	_	_	_	_
45	hepatoprotective	hepatoprotective	ADJ	JJ	Degree=Pos	_	_	_	_
46	activity	activity	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
47	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1116
# text = We report the effect of E3330 on transcriptional activation of tumor necrosis factor (TNF)-alpha gene and on nuclear factor (NF)-kappa B activation.
1	We	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
2	report	report	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
3	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
4	effect	effect	NOUN	NN	Number=Sing	_	_	_	_
5	of	of	ADP	IN	_	_	_	_	_
6	E3330	E3330	NUM	CD	NumType=Card	_	_	_	_
7	on	on	ADP	IN	_	_	_	_	_
8	transcriptional	transcriptional	ADJ	JJ	Degree=Pos	_	_	_	_
9	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
10	of	of	ADP	IN	_	_	_	_	_
11	tumor	tumor	NOUN	NN	Number=Sing	_	_	_	_
12	necrosis	necrosis	NOUN	NN	Number=Sing	_	_	_	_
13	factor	factor	NOUN	NN	Number=Sing	_	_	_	_
14	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
15	TNF	TNF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
16	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
17	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
18	alpha	alpha	NOUN	NN	Number=Sing	_	_	_	_
19	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
20	and	and	CCONJ	CC	_	_	_	_	_
21	on	on	ADP	IN	_	_	_	_	_
22	nuclear	nuclear	ADJ	JJ	Degree=Pos	_	_	_	_
23	factor	factor	NOUN	NN	Number=Sing	_	_	_	_
24	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
25	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
26	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
27	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
28	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_
29	B	b	NOUN	NN	Number=Sing	_	_	_	_
30	activation	activation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
31	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1117
# text = Nuclear run-on experiments showed that E3330 decreases transcriptional activation of TNF-alpha gene induced by lipopolysaccharide (LPS) stimulation in human peripheral monocytes.
1	Nuclear	nuclear	ADJ	JJ	Degree=Pos	_	_	_	_
2	run	run	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	SpaceAfter=No
3	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
4	on	on	ADP	IN	_	_	_	_	_
5	experiments	experiment	NOUN	NNS	Number=Plur	_	_	_	_
6	showed	show	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
7	that	that	SCONJ	IN	_	_	_	_	_
8	E3330	E3330	PROPN	NNP	Number=Sing	_	_	_	_
9	decreases	decrease	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
10	transcriptional	transcriptional	ADJ	JJ	Degree=Pos	_	_	_	_
11	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
12	of	of	ADP	IN	_	_	_	_	_
13	TNF	TNF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
14	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
15	alpha	alpha	NOUN	NN	Number=Sing	_	_	_	_
16	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
17	induced	induce	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
18	by	by	ADP	IN	_	_	_	_	_
19	lipopolysaccharide	lipopolysaccharide	NOUN	NN	Number=Sing	_	_	_	_
20	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
21	LPS	LPS	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
22	)	)	PUNCT	-RRB-	_	_	_	_	_
23	stimulation	stimulation	NOUN	NN	Number=Sing	_	_	_	_
24	in	in	ADP	IN	_	_	_	_	_
25	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
26	peripheral	peripheral	ADJ	JJ	Degree=Pos	_	_	_	_
27	monocytes	monocyte	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
28	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1118
# text = To investigate the inhibitory mechanisms, we constructed a secreted-type placental alkaline phosphatase (PLAP) reporter gene whose transcription is controlled by a 1.4-kb human TNF-alpha promoter.
1	To	to	PART	TO	_	_	_	_	_
2	investigate	investigate	VERB	VB	VerbForm=Inf	_	_	_	_
3	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
4	inhibitory	inhibitory	NOUN	NN	Number=Sing	_	_	_	_
5	mechanisms	mechanism	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
6	,	,	PUNCT	,	_	_	_	_	_
7	we	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
8	constructed	construct	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
9	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
10	secreted	secret	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	SpaceAfter=No
11	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
12	type	type	NOUN	NN	Number=Sing	_	_	_	_
13	placental	placental	NOUN	NN	Number=Sing	_	_	_	_
14	alkaline	alkaline	NOUN	NN	Number=Sing	_	_	_	_
15	phosphatase	phosphatase	NOUN	NN	Number=Sing	_	_	_	_
16	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
17	PLAP	PLAP	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
18	)	)	PUNCT	-RRB-	_	_	_	_	_
19	reporter	reporter	NOUN	NN	Number=Sing	_	_	_	_
20	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
21	whose	whose	PRON	WP$	Poss=Yes|PronType=Int	_	_	_	_
22	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
23	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
24	controlled	controll	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
25	by	by	ADP	IN	_	_	_	_	_
26	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
27	1.4	1.4	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
28	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
29	kb	kb	NOUN	NN	Number=Sing	_	_	_	_
30	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
31	TNF	Tnf	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
32	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
33	alpha	alpha	NOUN	NN	Number=Sing	_	_	_	_
34	promoter	promoter	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
35	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1119
# text = A stable transformant of the PLAP reporter gene derived from human monocytic cell line showed very little activity on the promoter before stimulation, whereas LPS stimulation led to a dramatic increase in PLAP activity.
1	A	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
2	stable	stable	ADJ	JJ	Degree=Pos	_	_	_	_
3	transformant	transformant	NOUN	NN	Number=Sing	_	_	_	_
4	of	of	ADP	IN	_	_	_	_	_
5	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
6	PLAP	PLAP	PROPN	NNP	Number=Sing	_	_	_	_
7	reporter	reporter	NOUN	NN	Number=Sing	_	_	_	_
8	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
9	derived	derive	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
10	from	from	ADP	IN	_	_	_	_	_
11	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
12	monocytic	monocytic	ADJ	JJ	Degree=Pos	_	_	_	_
13	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
14	line	line	NOUN	NN	Number=Sing	_	_	_	_
15	showed	show	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
16	very	very	ADV	RB	_	_	_	_	_
17	little	little	ADJ	JJ	Degree=Pos	_	_	_	_
18	activity	activity	NOUN	NN	Number=Sing	_	_	_	_
19	on	on	ADP	IN	_	_	_	_	_
20	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
21	promoter	promoter	NOUN	NN	Number=Sing	_	_	_	_
22	before	before	ADP	IN	_	_	_	_	_
23	stimulation	stimulation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
24	,	,	PUNCT	,	_	_	_	_	_
25	whereas	whereas	SCONJ	IN	_	_	_	_	_
26	LPS	LPS	PROPN	NNP	Number=Sing	_	_	_	_
27	stimulation	stimulation	NOUN	NN	Number=Sing	_	_	_	_
28	led	lead	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
29	to	to	ADP	IN	_	_	_	_	_
30	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
31	dramatic	dramatic	ADJ	JJ	Degree=Pos	_	_	_	_
32	increase	increase	NOUN	NN	Number=Sing	_	_	_	_
33	in	in	ADP	IN	_	_	_	_	_
34	PLAP	Plap	NOUN	NN	Number=Sing	_	_	_	_
35	activity	activity	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
36	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1120
# text = E3330 inhibited this induced promoter activity in a dose-dependent manner.
1	E3330	E3330	PROPN	NNP	Number=Sing	_	_	_	_
2	inhibited	inhibit	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
3	this	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
4	induced	induce	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
5	promoter	promoter	NOUN	NN	Number=Sing	_	_	_	_
6	activity	activity	NOUN	NN	Number=Sing	_	_	_	_
7	in	in	ADP	IN	_	_	_	_	_
8	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
9	dose	dose	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
10	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
11	dependent	dependent	ADJ	JJ	Degree=Pos	_	_	_	_
12	manner	manner	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
13	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1121
# text = There are four putative NF-kappa B binding sites (kappa B-1, kappa B-2, kappa B-3, kappa B-4) in human TNF-alpha promoter.
1	There	there	PRON	EX	_	_	_	_	_
2	are	be	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
3	four	four	NUM	CD	NumType=Card	_	_	_	_
4	putative	putative	ADJ	JJ	Degree=Pos	_	_	_	_
5	NF	Nf	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
6	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
7	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_
8	B	b	NOUN	NN	Number=Sing	_	_	_	_
9	binding	bind	VERB	VBG	VerbForm=Ger	_	_	_	_
10	sites	site	NOUN	NNS	Number=Plur	_	_	_	_
11	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
12	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_
13	B	b	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
14	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
15	1	1	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
16	,	,	PUNCT	,	_	_	_	_	_
17	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_
18	B	b	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
19	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
20	2	2	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
21	,	,	PUNCT	,	_	_	_	_	_
22	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_
23	B	b	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
24	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
25	3	3	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
26	,	,	PUNCT	,	_	_	_	_	_
27	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_
28	B	b	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
29	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
30	4	4	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
31	)	)	PUNCT	-RRB-	_	_	_	_	_
32	in	in	ADP	IN	_	_	_	_	_
33	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
34	TNF	Tnf	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
35	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
36	alpha	alpha	NOUN	NN	Number=Sing	_	_	_	_
37	promoter	promoter	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
38	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1122
# text = By using mutated promoter-PLAP plasmids, we established that these NF-kappa B sites were necessary for induction of TNF-alpha transcription on stimulation with LPS.
1	By	by	SCONJ	IN	_	_	_	_	_
2	using	use	VERB	VBG	VerbForm=Ger	_	_	_	_
3	mutated	mutate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
4	promoter	promoter	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
5	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
6	PLAP	pLAp	NOUN	NN	Number=Sing	_	_	_	_
7	plasmids	plasmid	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
8	,	,	PUNCT	,	_	_	_	_	_
9	we	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
10	established	establish	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
11	that	that	SCONJ	IN	_	_	_	_	_
12	these	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
13	NF	Nf	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
14	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
15	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_
16	B	b	NOUN	NN	Number=Sing	_	_	_	_
17	sites	site	NOUN	NNS	Number=Plur	_	_	_	_
18	were	be	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
19	necessary	necessary	ADJ	JJ	Degree=Pos	_	_	_	_
20	for	for	ADP	IN	_	_	_	_	_
21	induction	induction	NOUN	NN	Number=Sing	_	_	_	_
22	of	of	ADP	IN	_	_	_	_	_
23	TNF	TNF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
24	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
25	alpha	alpha	NOUN	NN	Number=Sing	_	_	_	_
26	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
27	on	on	ADP	IN	_	_	_	_	_
28	stimulation	stimulation	NOUN	NN	Number=Sing	_	_	_	_
29	with	with	ADP	IN	_	_	_	_	_
30	LPS	LPS	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
31	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1123
# text = A gel retardation experiment with synthetic double-stranded oligonucleotides showed that activated NF-kappa B consisting of p50/p65 heterodimer bound to all four putative NF-kappa B DNA probes, suggesting that all four putative NF-kappa B recognition sites play an important role in inducible TNF-alpha expression.
1	A	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
2	gel	gel	NOUN	NN	Number=Sing	_	_	_	_
3	retardation	retardation	NOUN	NN	Number=Sing	_	_	_	_
4	experiment	experiment	NOUN	NN	Number=Sing	_	_	_	_
5	with	with	ADP	IN	_	_	_	_	_
6	synthetic	synthetic	ADJ	JJ	Degree=Pos	_	_	_	_
7	double	double	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
8	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
9	stranded	strand	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
10	oligonucleotides	oligonucleotide	NOUN	NNS	Number=Plur	_	_	_	_
11	showed	show	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
12	that	that	SCONJ	IN	_	_	_	_	_
13	activated	activate	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
14	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
15	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
16	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_
17	B	b	NOUN	NN	Number=Sing	_	_	_	_
18	consisting	consisting	VERB	VBG	VerbForm=Ger	_	_	_	_
19	of	of	ADP	IN	_	_	_	_	_
20	p50	p50	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
21	/	/	PUNCT	,	_	_	_	_	SpaceAfter=No
22	p65	p65	NUM	CD	NumType=Card	_	_	_	_
23	heterodimer	heterodimer	NOUN	NN	Number=Sing	_	_	_	_
24	bound	bound	ADJ	JJ	Degree=Pos	_	_	_	_
25	to	to	ADP	IN	_	_	_	_	_
26	all	all	DET	DT	_	_	_	_	_
27	four	four	NUM	CD	NumType=Card	_	_	_	_
28	putative	putative	ADJ	JJ	Degree=Pos	_	_	_	_
29	NF	Nf	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
30	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
31	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_
32	B	b	NOUN	NN	Number=Sing	_	_	_	_
33	DNA	dna	NOUN	NN	Number=Sing	_	_	_	_
34	probes	probe	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
35	,	,	PUNCT	,	_	_	_	_	_
36	suggesting	suggest	VERB	VBG	VerbForm=Ger	_	_	_	_
37	that	that	SCONJ	IN	_	_	_	_	_
38	all	all	DET	DT	_	_	_	_	_
39	four	four	NUM	CD	NumType=Card	_	_	_	_
40	putative	putative	ADJ	JJ	Degree=Pos	_	_	_	_
41	NF	Nf	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
42	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
43	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_
44	B	b	NOUN	NN	Number=Sing	_	_	_	_
45	recognition	recognition	NOUN	NN	Number=Sing	_	_	_	_
46	sites	site	NOUN	NNS	Number=Plur	_	_	_	_
47	play	play	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
48	an	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
49	important	important	ADJ	JJ	Degree=Pos	_	_	_	_
50	role	role	NOUN	NN	Number=Sing	_	_	_	_
51	in	in	ADP	IN	_	_	_	_	_
52	inducible	inducible	ADJ	JJ	Degree=Pos	_	_	_	_
53	TNF	TNF	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
54	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
55	alpha	alpha	NOUN	NN	Number=Sing	_	_	_	_
56	expression	expression	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
57	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1124
# text = E3330 decreased activated NF-kappa B in nuclei, suggesting that E3330 inhibits NF-kappa B activation and/or translocation of the nuclei.
1	E3330	E3330	PROPN	NNP	Number=Sing	_	_	_	_
2	decreased	decrease	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
3	activated	activate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
4	NF	Nf	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
5	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
6	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_
7	B	b	NOUN	NN	Number=Sing	_	_	_	_
8	in	in	ADP	IN	_	_	_	_	_
9	nuclei	nuclei	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
10	,	,	PUNCT	,	_	_	_	_	_
11	suggesting	suggest	VERB	VBG	VerbForm=Ger	_	_	_	_
12	that	that	SCONJ	IN	_	_	_	_	_
13	E3330	E3330	PROPN	NNP	Number=Sing	_	_	_	_
14	inhibits	inhibit	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
15	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
16	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
17	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_
18	B	b	NOUN	NN	Number=Sing	_	_	_	_
19	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
20	and	and	CCONJ	CC	_	_	_	_	SpaceAfter=No
21	/	/	PUNCT	,	_	_	_	_	SpaceAfter=No
22	or	or	CCONJ	CC	_	_	_	_	_
23	translocation	translocation	NOUN	NN	Number=Sing	_	_	_	_
24	of	of	ADP	IN	_	_	_	_	_
25	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
26	nuclei	nuclei	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
27	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1125
# text = Western blotting analysis with anti-I kappa B-alpha antibody indicated that E3330 inhibited degradation of I kappa B-alpha, which is an inhibitory protein of NF-kappa B, in LPS-stimulated monocytes.
1	Western	western	ADJ	JJ	Degree=Pos	_	_	_	_
2	blotting	blott	NOUN	NN	Number=Sing	_	_	_	_
3	analysis	analysis	NOUN	NN	Number=Sing	_	_	_	_
4	with	with	ADP	IN	_	_	_	_	_
5	anti	anti	X	AFX	_	_	_	_	SpaceAfter=No
6	-I	-i	X	AFX	_	_	_	_	_
7	kappa	kappa	X	FW	Foreign=Yes	_	_	_	_
8	B-	B-	X	GW	_	_	_	_	SpaceAfter=No
9	alpha	alpha	X	FW	Foreign=Yes	_	_	_	_
10	antibody	antibody	PRON	NN	Number=Sing	_	_	_	_
11	indicated	indicate	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
12	that	that	SCONJ	IN	_	_	_	_	_
13	E3330	E3330	PROPN	NNP	Number=Sing	_	_	_	_
14	inhibited	inhibit	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
15	degradation	degradation	NOUN	NN	Number=Sing	_	_	_	_
16	of	of	ADP	IN	_	_	_	_	_
17	I	I	PRON	PRP	Case=Nom|Number=Sing|Person=1|PronType=Prs	_	_	_	_
18	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_
19	B-	B-	PUNCT	,	_	_	_	_	SpaceAfter=No
20	alpha	alpha	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
21	,	,	PUNCT	,	_	_	_	_	_
22	which	which	PRON	WDT	PronType=Rel	_	_	_	_
23	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
24	an	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
25	inhibitory	inhibitory	ADJ	JJ	Degree=Pos	_	_	_	_
26	protein	protein	NOUN	NN	Number=Sing	_	_	_	_
27	of	of	ADP	IN	_	_	_	_	_
28	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
29	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
30	kappa	kappa	PROPN	NNP	Number=Sing	_	_	_	_
31	B	b	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
32	,	,	PUNCT	,	_	_	_	_	_
33	in	in	ADP	IN	_	_	_	_	_
34	LPS	LPS	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
35	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
36	stimulated	stimulate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
37	monocytes	monocyte	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
38	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1126
# text = E3330 may suppress the production of active oxygen species serving as common messengers to activate NF-kappa B.
1	E3330	E3330	PROPN	NNP	Number=Sing	_	_	_	_
2	may	may	AUX	MD	VerbForm=Fin	_	_	_	_
3	suppress	suppress	VERB	VB	VerbForm=Inf	_	_	_	_
4	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
5	production	production	NOUN	NN	Number=Sing	_	_	_	_
6	of	of	ADP	IN	_	_	_	_	_
7	active	active	ADJ	JJ	Degree=Pos	_	_	_	_
8	oxygen	oxygen	NOUN	NN	Number=Sing	_	_	_	_
9	species	species	NOUN	NNS	Number=Plur	_	_	_	_
10	serving	serve	VERB	VBG	VerbForm=Ger	_	_	_	_
11	as	as	ADP	IN	_	_	_	_	_
12	common	common	ADJ	JJ	Degree=Pos	_	_	_	_
13	messengers	messenger	NOUN	NNS	Number=Plur	_	_	_	_
14	to	to	PART	TO	_	_	_	_	_
15	activate	activate	VERB	VB	VerbForm=Inf	_	_	_	_
16	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
17	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
18	kappa	kappa	PROPN	NNP	Number=Sing	_	_	_	_
19	B.	B.	PROPN	NNP	Number=Sing	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 1127
# text = Document 003002392 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	003002392	003002392	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 1128
# text = Activation of the interleukin 6 gene by Mycobacterium tuberculosis or lipopolysaccharide is mediated by nuclear factors NF-IL6 and NF-kappa B [published erratum appears in Proc Natl Acad Sci U S A 1995 Apr 11;92(8):3632]
1	Activation	Activation	NOUN	NN	Number=Sing	_	_	_	_
2	of	of	ADP	IN	_	_	_	_	_
3	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
4	interleukin	interleukin	ADJ	JJ	Degree=Pos	_	_	_	_
5	6	6	NUM	CD	NumType=Card	_	_	_	_
6	gene	gene	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
7	by	by	ADP	IN	_	_	_	_	_
8	Mycobacterium	Mycobacterium	PROPN	NNP	Number=Sing	_	_	_	_
9	tuberculosis	tuberculosis	NOUN	NN	Number=Sing	_	_	_	_
10	or	or	CCONJ	CC	_	_	_	_	_
11	lipopolysaccharide	lipopolysaccharide	NOUN	NN	Number=Sing	_	_	_	_
12	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
13	mediated	mediate	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
14	by	by	ADP	IN	_	_	_	_	_
15	nuclear	nuclear	ADJ	JJ	Degree=Pos	_	_	_	_
16	factors	factor	NOUN	NNS	Number=Plur	_	_	_	_
17	NF	Nf	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
18	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
19	IL6	IL6	PROPN	NNP	Number=Sing	_	_	_	_
20	and	and	CCONJ	CC	_	_	_	_	_
21	NF	Nf	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
22	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
23	kappa	kappa	PROPN	NNP	Number=Sing	_	_	_	_
24	B	b	PROPN	NNP	Number=Sing	_	_	_	_
25	[	[	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
26	published	publish	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
27	erratum	erratum	NOUN	NN	Number=Sing	_	_	_	_
28	appears	appear	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
29	in	in	ADP	IN	_	_	_	_	_
30	Proc	Proc	PROPN	NNP	Number=Sing	_	_	_	_
31	Natl	Natl	PROPN	NNP	Number=Sing	_	_	_	_
32	Acad	Acad	PROPN	NNP	Number=Sing	_	_	_	_
33	Sci	sci	PROPN	NNP	Number=Sing	_	_	_	_
34	U	U	PROPN	NNP	Number=Sing	_	_	_	_
35	S	be	PART	POS	_	_	_	_	_
36	A	a	PROPN	NNP	Number=Sing	_	_	_	_
37	1995	1995	NUM	CD	NumType=Card	_	_	_	_
38	Apr	Apr	PROPN	NNP	Number=Sing	_	_	_	_
39	11;92	11;92	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
40	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
41	8):3632	8):3632	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
42	]	]	PUNCT	-RRB-	_	_	_	_	SpacesAfter=\s\n

# sent_id = 1129
# text = The host response to Mycobacterium tuberculosis includes granuloma formation at sites of infection and systemic symptoms.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	host	host	NOUN	NN	Number=Sing	_	_	_	_
3	response	response	NOUN	NN	Number=Sing	_	_	_	_
4	to	to	ADP	IN	_	_	_	_	_
5	Mycobacterium	Mycobacterium	PROPN	NNP	Number=Sing	_	_	_	_
6	tuberculosis	tuberculosis	PRON	PRP$	Gender=Masc|Number=Sing|Person=3|Poss=Yes|PronType=Prs	_	_	_	_
7	includes	include	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
8	granuloma	granuloma	NOUN	NN	Number=Sing	_	_	_	_
9	formation	formation	NOUN	NN	Number=Sing	_	_	_	_
10	at	at	ADP	IN	_	_	_	_	_
11	sites	site	NOUN	NNS	Number=Plur	_	_	_	_
12	of	of	ADP	IN	_	_	_	_	_
13	infection	infection	NOUN	NN	Number=Sing	_	_	_	_
14	and	and	CCONJ	CC	_	_	_	_	_
15	systemic	systemic	ADJ	JJ	Degree=Pos	_	_	_	_
16	symptoms	symptom	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
17	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1130
# text = Cytokines have been identified by immunohistochemistry in granulomas in animal models of bacillus Calmette-Guerin (BCG) infection and are released by mononuclear phagocytes upon stimulation by mycobacterial proteins.
1	Cytokines	Cytokine	NOUN	NNS	Number=Plur	_	_	_	_
2	have	have	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
3	been	be	AUX	VBN	Tense=Past|VerbForm=Part	_	_	_	_
4	identified	identify	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
5	by	by	ADP	IN	_	_	_	_	_
6	immunohistochemistry	immunohistochemistry	NOUN	NN	Number=Sing	_	_	_	_
7	in	in	ADP	IN	_	_	_	_	_
8	granulomas	granuloma	NOUN	NNS	Number=Plur	_	_	_	_
9	in	in	ADP	IN	_	_	_	_	_
10	animal	animal	NOUN	NN	Number=Sing	_	_	_	_
11	models	model	NOUN	NNS	Number=Plur	_	_	_	_
12	of	of	ADP	IN	_	_	_	_	_
13	bacillus	bacillus	ADJ	JJ	Degree=Pos	_	_	_	_
14	Calmette	Calmette	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
15	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
16	Guerin	Guerin	PROPN	NNP	Number=Sing	_	_	_	_
17	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
18	BCG	BCG	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
19	)	)	PUNCT	-RRB-	_	_	_	_	_
20	infection	infection	NOUN	NN	Number=Sing	_	_	_	_
21	and	and	CCONJ	CC	_	_	_	_	_
22	are	be	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
23	released	release	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
24	by	by	ADP	IN	_	_	_	_	_
25	mononuclear	mononuclear	ADJ	JJ	Degree=Pos	_	_	_	_
26	phagocytes	phagocyte	NOUN	NNS	Number=Plur	_	_	_	_
27	upon	upon	ADP	IN	_	_	_	_	_
28	stimulation	stimulation	NOUN	NN	Number=Sing	_	_	_	_
29	by	by	ADP	IN	_	_	_	_	_
30	mycobacterial	mycobacterial	ADJ	JJ	Degree=Pos	_	_	_	_
31	proteins	protein	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
32	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1131
# text = In this regard, the cytokine interleukin 6 (IL-6) may play a role in the clinical manifestations and pathological events of tuberculosis infection.
1	In	in	ADP	IN	_	_	_	_	_
2	this	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
3	regard	regard	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
4	,	,	PUNCT	,	_	_	_	_	_
5	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
6	cytokine	cytokine	NOUN	NN	Number=Sing	_	_	_	_
7	interleukin	interleukin	NOUN	NN	Number=Sing	_	_	_	_
8	6	6	NUM	CD	NumType=Card	_	_	_	_
9	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
10	IL	Il	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
11	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
12	6	6	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
13	)	)	PUNCT	-RRB-	_	_	_	_	_
14	may	may	AUX	MD	VerbForm=Fin	_	_	_	_
15	play	play	VERB	VB	VerbForm=Inf	_	_	_	_
16	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
17	role	role	NOUN	NN	Number=Sing	_	_	_	_
18	in	in	ADP	IN	_	_	_	_	_
19	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
20	clinical	clinical	ADJ	JJ	Degree=Pos	_	_	_	_
21	manifestations	manifestation	NOUN	NNS	Number=Plur	_	_	_	_
22	and	and	CCONJ	CC	_	_	_	_	_
23	pathological	pathological	ADJ	JJ	Degree=Pos	_	_	_	_
24	events	event	NOUN	NNS	Number=Plur	_	_	_	_
25	of	of	ADP	IN	_	_	_	_	_
26	tuberculosis	tuberculosis	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
27	infection	infection	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
28	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1132
# text = We have demonstrated that lipoarabinomannan (LAM) from the mycobacterial cell wall, which was virtually devoid of lipopolysaccharide (LPS), stimulated mononuclear phagocytes to release IL-6 in a dose-response manner.
1	We	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
2	have	have	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
3	demonstrated	demonstrate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
4	that	that	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
5	lipoarabinomannan	lipoarabinomannan	NOUN	NN	Number=Sing	_	_	_	_
6	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
7	LAM	LAm	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
8	)	)	PUNCT	-RRB-	_	_	_	_	_
9	from	from	ADP	IN	_	_	_	_	_
10	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
11	mycobacterial	mycobacterial	ADJ	JJ	Degree=Pos	_	_	_	_
12	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
13	wall	wall	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
14	,	,	PUNCT	,	_	_	_	_	_
15	which	which	PRON	WDT	PronType=Rel	_	_	_	_
16	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
17	virtually	virtually	ADV	RB	_	_	_	_	_
18	devoid	devoid	ADJ	JJ	Degree=Pos	_	_	_	_
19	of	of	ADP	IN	_	_	_	_	_
20	lipopolysaccharide	lipopolysaccharide	NOUN	NN	Number=Sing	_	_	_	_
21	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
22	LPS	LPS	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
23	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
24	,	,	PUNCT	,	_	_	_	_	_
25	stimulated	stimulate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
26	mononuclear	mononuclear	ADJ	JJ	Degree=Pos	_	_	_	_
27	phagocytes	phagocyte	NOUN	NNS	Number=Plur	_	_	_	_
28	to	to	PART	TO	_	_	_	_	_
29	release	release	VERB	VB	VerbForm=Inf	_	_	_	_
30	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
31	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
32	6	6	NUM	CD	NumType=Card	_	_	_	_
33	in	in	ADP	IN	_	_	_	_	_
34	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
35	dose	dose	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
36	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
37	response	response	NOUN	NN	Number=Sing	_	_	_	_
38	manner	manner	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
39	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1133
# text = LAM and LPS were potent inducers of IL-6 gene expression in peripheral blood monocytes.
1	LAM	LAM	PROPN	NNP	Number=Sing	_	_	_	_
2	and	and	CCONJ	CC	_	_	_	_	_
3	LPS	LPS	PROPN	NNP	Number=Sing	_	_	_	_
4	were	be	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
5	potent	potent	ADJ	JJ	Degree=Pos	_	_	_	_
6	inducers	inducer	NOUN	NNS	Number=Plur	_	_	_	_
7	of	of	ADP	IN	_	_	_	_	_
8	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
9	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
10	6	6	NUM	CD	NumType=Card	_	_	_	_
11	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
12	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
13	in	in	ADP	IN	_	_	_	_	_
14	peripheral	peripheral	ADJ	JJ	Degree=Pos	_	_	_	_
15	blood	blood	NOUN	NN	Number=Sing	_	_	_	_
16	monocytes	monocyte	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
17	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1134
# text = Both LAM- and LPS-inducible IL-6 promoter activity was localized to a DNA fragment, positions -158 to -49, by deletion analysis and chloramphenicol acetyltransferase assay.
1	Both	both	DET	DT	_	_	_	_	_
2	LAM	LAm	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
3	-	-	PUNCT	,	_	_	_	_	_
4	and	and	CCONJ	CC	_	_	_	_	_
5	LPS	Lps	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
6	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
7	inducible	inducible	ADJ	JJ	Degree=Pos	_	_	_	_
8	IL	Il	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
9	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
10	6	6	NUM	CD	NumType=Card	_	_	_	_
11	promoter	promoter	NOUN	NN	Number=Sing	_	_	_	_
12	activity	activity	NOUN	NN	Number=Sing	_	_	_	_
13	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
14	localized	localize	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
15	to	to	ADP	IN	_	_	_	_	_
16	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
17	DNA	dna	NOUN	NN	Number=Sing	_	_	_	_
18	fragment	fragment	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
19	,	,	PUNCT	,	_	_	_	_	_
20	positions	position	NOUN	NNS	Number=Plur	_	_	_	_
21	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
22	158	158	NUM	CD	NumType=Card	_	_	_	_
23	to	to	ADP	IN	_	_	_	_	_
24	-	-	SYM	SYM	_	_	_	_	SpaceAfter=No
25	49	49	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
26	,	,	PUNCT	,	_	_	_	_	_
27	by	by	ADP	IN	_	_	_	_	_
28	deletion	deletion	NOUN	NN	Number=Sing	_	_	_	_
29	analysis	analysis	NOUN	NN	Number=Sing	_	_	_	_
30	and	and	CCONJ	CC	_	_	_	_	_
31	chloramphenicol	chloramphenicol	NOUN	NN	Number=Sing	_	_	_	_
32	acetyltransferase	acetyltransferase	NOUN	NN	Number=Sing	_	_	_	_
33	assay	assay	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
34	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1135
# text = Two nuclear factor NF-IL6 (positions -153 to -145 and -83 to -75) and one nuclear factor NF-kappa B (positions -72 to -63) motifs are present within this fragment.
1	Two	two	NUM	CD	NumType=Card	_	_	_	_
2	nuclear	nuclear	ADJ	JJ	Degree=Pos	_	_	_	_
3	factor	factor	NOUN	NN	Number=Sing	_	_	_	_
4	NF	Nf	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
5	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
6	IL6	Il6	PROPN	NNP	Number=Sing	_	_	_	_
7	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
8	positions	position	NOUN	NNS	Number=Plur	_	_	_	_
9	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
10	153	153	NUM	CD	NumType=Card	_	_	_	_
11	to	to	ADP	IN	_	_	_	_	_
12	-	-	SYM	SYM	_	_	_	_	SpaceAfter=No
13	145	145	NUM	CD	NumType=Card	_	_	_	_
14	and	and	CCONJ	CC	_	_	_	_	_
15	-	-	SYM	SYM	_	_	_	_	SpaceAfter=No
16	83	83	NUM	CD	NumType=Card	_	_	_	_
17	to	to	ADP	IN	_	_	_	_	_
18	-	-	SYM	SYM	_	_	_	_	SpaceAfter=No
19	75	75	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
20	)	)	PUNCT	-RRB-	_	_	_	_	_
21	and	and	CCONJ	CC	_	_	_	_	_
22	one	one	NUM	CD	NumType=Card	_	_	_	_
23	nuclear	nuclear	ADJ	JJ	Degree=Pos	_	_	_	_
24	factor	factor	NOUN	NN	Number=Sing	_	_	_	_
25	NF	Nf	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
26	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
27	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_
28	B	b	NOUN	NN	Number=Sing	_	_	_	_
29	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
30	positions	position	NOUN	NNS	Number=Plur	_	_	_	_
31	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
32	72	72	NUM	CD	NumType=Card	_	_	_	_
33	to	to	ADP	IN	_	_	_	_	_
34	-	-	SYM	SYM	_	_	_	_	SpaceAfter=No
35	63	63	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
36	)	)	PUNCT	-RRB-	_	_	_	_	_
37	motifs	motif	NOUN	NNS	Number=Plur	_	_	_	_
38	are	be	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
39	present	present	ADJ	JJ	Degree=Pos	_	_	_	_
40	within	within	ADP	IN	_	_	_	_	_
41	this	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
42	fragment	fragment	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
43	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1136
# text = Site-directed mutagenesis of one or more of these motifs within the IL-6 promoter demonstrated that each has positive regulatory activity and that they could act in a function- and orientation-independent manner.
1	Site	site	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
2	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
3	directed	direct	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
4	mutagenesis	mutagenesis	NOUN	NN	Number=Sing	_	_	_	_
5	of	of	ADP	IN	_	_	_	_	_
6	one	one	NUM	CD	NumType=Card	_	_	_	_
7	or	or	CCONJ	CC	_	_	_	_	_
8	more	more	ADJ	JJR	Degree=Cmp	_	_	_	_
9	of	of	ADP	IN	_	_	_	_	_
10	these	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
11	motifs	motif	NOUN	NNS	Number=Plur	_	_	_	_
12	within	within	ADP	IN	_	_	_	_	_
13	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
14	IL	Il	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
15	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
16	6	6	NUM	CD	NumType=Card	_	_	_	_
17	promoter	promoter	NOUN	NN	Number=Sing	_	_	_	_
18	demonstrated	demonstrate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
19	that	that	SCONJ	IN	_	_	_	_	_
20	each	each	DET	DT	_	_	_	_	_
21	has	have	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
22	positive	positive	ADJ	JJ	Degree=Pos	_	_	_	_
23	regulatory	regulatory	ADJ	JJ	Degree=Pos	_	_	_	_
24	activity	activity	NOUN	NN	Number=Sing	_	_	_	_
25	and	and	CCONJ	CC	_	_	_	_	_
26	that	that	SCONJ	IN	_	_	_	_	_
27	they	they	PRON	PRP	Case=Nom|Number=Plur|Person=3|PronType=Prs	_	_	_	_
28	could	could	AUX	MD	VerbForm=Fin	_	_	_	_
29	act	act	VERB	VB	VerbForm=Inf	_	_	_	_
30	in	in	ADP	IN	_	_	_	_	_
31	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
32	function	function	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
33	-	-	PUNCT	,	_	_	_	_	_
34	and	and	CCONJ	CC	_	_	_	_	_
35	orientation	orientation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
36	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
37	independent	independent	ADJ	JJ	Degree=Pos	_	_	_	_
38	manner	manner	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
39	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1137
# text = Deletion of all three elements abolished inducibility of IL-6 promoter activity by both LAM and LPS.
1	Deletion	Deletion	NOUN	NN	Number=Sing	_	_	_	_
2	of	of	ADP	IN	_	_	_	_	_
3	all	all	DET	DT	_	_	_	_	_
4	three	three	NUM	CD	NumType=Card	_	_	_	_
5	elements	element	NOUN	NNS	Number=Plur	_	_	_	_
6	abolished	abolish	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
7	inducibility	inducibility	NOUN	NN	Number=Sing	_	_	_	_
8	of	of	ADP	IN	_	_	_	_	_
9	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
10	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
11	6	6	NUM	CD	NumType=Card	_	_	_	_
12	promoter	promoter	NOUN	NN	Number=Sing	_	_	_	_
13	activity	activity	NOUN	NN	Number=Sing	_	_	_	_
14	by	by	ADP	IN	_	_	_	_	_
15	both	both	CCONJ	CC	_	_	_	_	_
16	LAM	LAm	PROPN	NNP	Number=Sing	_	_	_	_
17	and	and	CCONJ	CC	_	_	_	_	_
18	LPS	Lp	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
19	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1138
# text = We conclude that the NF-IL6 and NF-kappa B sites mediate IL-6 induction in response to both LPS and LAM, acting as bacterial or mycobacterial response elements.
1	We	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
2	conclude	conclude	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
3	that	that	SCONJ	IN	_	_	_	_	_
4	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
5	NF	Nf	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
6	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
7	IL6	Il6	PROPN	NNP	Number=Sing	_	_	_	_
8	and	and	CCONJ	CC	_	_	_	_	_
9	NF	Nf	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
10	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
11	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_
12	B	b	NOUN	NN	Number=Sing	_	_	_	_
13	sites	site	NOUN	NNS	Number=Plur	_	_	_	_
14	mediate	mediate	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
15	IL	Il	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
16	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
17	6	6	NUM	CD	NumType=Card	_	_	_	_
18	induction	induction	NOUN	NN	Number=Sing	_	_	_	_
19	in	in	ADP	IN	_	_	_	_	_
20	response	response	NOUN	NN	Number=Sing	_	_	_	_
21	to	to	ADP	IN	_	_	_	_	_
22	both	both	DET	DT	_	_	_	_	_
23	LPS	Lp	NOUN	NNS	Number=Plur	_	_	_	_
24	and	and	CCONJ	CC	_	_	_	_	_
25	LAM	LAm	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
26	,	,	PUNCT	,	_	_	_	_	_
27	acting	act	VERB	VBG	VerbForm=Ger	_	_	_	_
28	as	as	ADP	IN	_	_	_	_	_
29	bacterial	bacterial	ADJ	JJ	Degree=Pos	_	_	_	_
30	or	or	CCONJ	CC	_	_	_	_	_
31	mycobacterial	mycobacterial	ADJ	JJ	Degree=Pos	_	_	_	_
32	response	response	NOUN	NN	Number=Sing	_	_	_	_
33	elements	element	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
34	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 1139
# text = Document 003002394 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	003002394	003002394	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 1140
# text = Homodimerization of the human interleukin 4 receptor alpha chain induces Cepsilon germline transcripts in B cells in the absence of the interleukin 2 receptor gamma chain.
1	Homodimerization	Homodimerization	NOUN	NN	Number=Sing	_	_	_	_
2	of	of	ADP	IN	_	_	_	_	_
3	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
4	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
5	interleukin	interleukin	NOUN	NN	Number=Sing	_	_	_	_
6	4	4	NUM	CD	NumType=Card	_	_	_	_
7	receptor	receptor	NOUN	NN	Number=Sing	_	_	_	_
8	alpha	alpha	NOUN	NN	Number=Sing	_	_	_	_
9	chain	chain	NOUN	NN	Number=Sing	_	_	_	_
10	induces	induce	NOUN	NNS	Number=Plur	_	_	_	_
11	Cepsilon	Cepsilon	ADP	IN	_	_	_	_	_
12	germline	germline	NOUN	NN	Number=Sing	_	_	_	_
13	transcripts	transcript	NOUN	NNS	Number=Plur	_	_	_	_
14	in	in	ADP	IN	_	_	_	_	_
15	B	b	ADJ	JJ	Degree=Pos	_	_	_	_
16	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
17	in	in	ADP	IN	_	_	_	_	_
18	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
19	absence	absence	NOUN	NN	Number=Sing	_	_	_	_
20	of	of	ADP	IN	_	_	_	_	_
21	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
22	interleukin	interleukin	NOUN	NN	Number=Sing	_	_	_	_
23	2	2	NUM	CD	NumType=Card	_	_	_	_
24	receptor	receptor	NOUN	NN	Number=Sing	_	_	_	_
25	gamma	gamma	NOUN	NN	Number=Sing	_	_	_	_
26	chain	chain	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
27	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 1141
# text = The cytokines interleukin (IL)-4 and IL-13 play a critical role in inducing Cepsilon germline transcripts and IgE isotype switching in human B cells.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	cytokines	cytokine	NOUN	NNS	Number=Plur	_	_	_	_
3	interleukin	interleukin	NOUN	NN	Number=Sing	_	_	_	_
4	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
5	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
6	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
7	-	-	SYM	SYM	_	_	_	_	SpaceAfter=No
8	4	4	NUM	CD	NumType=Card	_	_	_	_
9	and	and	CCONJ	CC	_	_	_	_	_
10	IL	Il	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
11	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
12	13	13	NUM	CD	NumType=Card	_	_	_	_
13	play	play	NOUN	NN	Number=Sing	_	_	_	_
14	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
15	critical	critical	ADJ	JJ	Degree=Pos	_	_	_	_
16	role	role	NOUN	NN	Number=Sing	_	_	_	_
17	in	in	SCONJ	IN	_	_	_	_	_
18	inducing	induce	VERB	VBG	VerbForm=Ger	_	_	_	_
19	Cepsilon	Cepsilon	PROPN	NNP	Number=Sing	_	_	_	_
20	germline	germline	NOUN	NN	Number=Sing	_	_	_	_
21	transcripts	transcript	NOUN	NNS	Number=Plur	_	_	_	_
22	and	and	CCONJ	CC	_	_	_	_	_
23	IgE	Ige	NOUN	NN	Number=Sing	_	_	_	_
24	isotype	isotype	NOUN	NN	Number=Sing	_	_	_	_
25	switching	switch	VERB	VBG	VerbForm=Ger	_	_	_	_
26	in	in	ADP	IN	_	_	_	_	_
27	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
28	B	b	ADJ	JJ	Degree=Pos	_	_	_	_
29	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
30	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1142
# text = The IL-4 receptor (IL-4R) in B cells is composed of two chains, the IL-4-binding IL-4Ralpha chain, which is shared with the IL-13R, and the IL-2Rgamma (gammac) chain, which is shared with IL-7R, IL-9R, and IL-15R.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	IL	Il	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
3	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
4	4	4	NUM	CD	NumType=Card	_	_	_	_
5	receptor	receptor	NOUN	NN	Number=Sing	_	_	_	_
6	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
7	IL	Il	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
8	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
9	4R	4r	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
10	)	)	PUNCT	-RRB-	_	_	_	_	_
11	in	in	ADP	IN	_	_	_	_	_
12	B	b	ADJ	JJ	Degree=Pos	_	_	_	_
13	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
14	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
15	composed	compose	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
16	of	of	ADP	IN	_	_	_	_	_
17	two	two	NUM	CD	NumType=Card	_	_	_	_
18	chains	chain	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
19	,	,	PUNCT	,	_	_	_	_	_
20	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
21	IL	Il	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
22	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
23	4	4	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
24	-binding	-binding	NOUN	NN	Number=Sing	_	_	_	_
25	IL	Il	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
26	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
27	4	4	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
28	Ralpha	Ralpha	PROPN	NNP	Number=Sing	_	_	_	_
29	chain	chain	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
30	,	,	PUNCT	,	_	_	_	_	_
31	which	which	PRON	WDT	PronType=Rel	_	_	_	_
32	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
33	shared	share	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
34	with	with	ADP	IN	_	_	_	_	_
35	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
36	IL	Il	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
37	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
38	13R	13r	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
39	,	,	PUNCT	,	_	_	_	_	_
40	and	and	CCONJ	CC	_	_	_	_	_
41	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
42	IL	Il	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
43	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
44	2	2	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
45	Rgamma	Rgamma	NOUN	NN	Number=Sing	_	_	_	_
46	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
47	gammac	gammac	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
48	)	)	PUNCT	-RRB-	_	_	_	_	_
49	chain	chain	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
50	,	,	PUNCT	,	_	_	_	_	_
51	which	which	PRON	WDT	PronType=Rel	_	_	_	_
52	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
53	shared	share	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
54	with	with	ADP	IN	_	_	_	_	_
55	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
56	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
57	7R	7R	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
58	,	,	PUNCT	,	_	_	_	_	_
59	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
60	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
61	9R	9R	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
62	,	,	PUNCT	,	_	_	_	_	_
63	and	and	CCONJ	CC	_	_	_	_	_
64	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
65	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
66	15R.	15R.	PROPN	NNP	Number=Sing	_	_	_	_

# sent_id = 1143
# text = IL-4 induces Cepsilon germline transcripts and IgE isotype switching in B cells from patients with gammac chain deficiency.
1	IL	Il	INTJ	UH	_	_	_	_	SpaceAfter=No
2	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
3	4	4	NUM	CD	NumType=Card	_	_	_	_
4	induces	induce	NOUN	NNS	Number=Plur	_	_	_	_
5	Cepsilon	Cepsilon	PROPN	NNP	Number=Sing	_	_	_	_
6	germline	germline	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
7	transcripts	transcript	NOUN	NNS	Number=Plur	_	_	_	_
8	and	and	CCONJ	CC	_	_	_	_	_
9	IgE	IgE	NOUN	NN	Number=Sing	_	_	_	_
10	isotype	isotype	NOUN	NN	Number=Sing	_	_	_	_
11	switching	switching	VERB	VBG	VerbForm=Ger	_	_	_	_
12	in	in	ADP	IN	_	_	_	_	_
13	B	b	ADJ	JJ	Degree=Pos	_	_	_	_
14	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
15	from	from	ADP	IN	_	_	_	_	_
16	patients	patient	NOUN	NNS	Number=Plur	_	_	_	_
17	with	with	ADP	IN	_	_	_	_	_
18	gammac	gammac	NOUN	NN	Number=Sing	_	_	_	_
19	chain	chain	NOUN	NN	Number=Sing	_	_	_	_
20	deficiency	deficiency	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
21	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1144
# text = Induction of Cepsilon germline transcripts by IL-4 in B cells that lack the gammac chain may involve signaling via the IL-13R.
1	Induction	Induction	NOUN	NN	Number=Sing	_	_	_	_
2	of	of	ADP	IN	_	_	_	_	_
3	Cepsilon	Cepsilon	PROPN	NNP	Number=Sing	_	_	_	_
4	germline	germline	NOUN	NN	Number=Sing	_	_	_	_
5	transcripts	transcript	NOUN	NNS	Number=Plur	_	_	_	_
6	by	by	ADP	IN	_	_	_	_	_
7	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
8	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
9	4	4	NUM	CD	NumType=Card	_	_	_	_
10	in	in	ADP	IN	_	_	_	_	_
11	B	b	ADJ	JJ	Degree=Pos	_	_	_	_
12	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
13	that	that	PRON	WDT	PronType=Rel	_	_	_	_
14	lack	lack	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
15	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
16	gammac	gammac	NOUN	NN	Number=Sing	_	_	_	_
17	chain	chain	NOUN	NN	Number=Sing	_	_	_	_
18	may	may	AUX	MD	VerbForm=Fin	_	_	_	_
19	involve	involve	VERB	VB	VerbForm=Inf	_	_	_	_
20	signaling	signal	VERB	VBG	VerbForm=Ger	_	_	_	_
21	via	via	ADP	IN	_	_	_	_	_
22	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
23	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
24	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
25	13R	13R	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
26	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1145
# text = Alternatively, the IL-4Ralpha chain may transduce intracellular signals that lead to Cepsilon gene transcription independently of its association with other chains.
1	Alternatively	Alternatively	ADV	RB	_	_	_	_	SpaceAfter=No
2	,	,	PUNCT	,	_	_	_	_	_
3	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
4	IL	Il	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
5	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
6	4	4	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
7	Ralpha	Ralpha	NOUN	NN	Number=Sing	_	_	_	_
8	chain	chain	NOUN	NN	Number=Sing	_	_	_	_
9	may	may	AUX	MD	VerbForm=Fin	_	_	_	_
10	transduce	transduce	VERB	VB	VerbForm=Inf	_	_	_	_
11	intracellular	intracellular	ADJ	JJ	Degree=Pos	_	_	_	_
12	signals	signal	NOUN	NNS	Number=Plur	_	_	_	_
13	that	that	PRON	WDT	PronType=Rel	_	_	_	_
14	lead	lead	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
15	to	to	ADP	IN	_	_	_	_	_
16	Cepsilon	Cepsilon	PROPN	NNP	Number=Sing	_	_	_	_
17	gene	gene	PROPN	NNP	Number=Sing	_	_	_	_
18	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
19	independently	independently	ADV	RB	_	_	_	_	_
20	of	of	ADP	IN	_	_	_	_	_
21	its	its	PRON	PRP$	Gender=Neut|Number=Sing|Person=3|Poss=Yes|PronType=Prs	_	_	_	_
22	association	association	NOUN	NN	Number=Sing	_	_	_	_
23	with	with	ADP	IN	_	_	_	_	_
24	other	other	ADJ	JJ	Degree=Pos	_	_	_	_
25	chains	chain	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
26	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1146
# text = We show that ligand-induced homodimerization of chimeric surface receptors consisting of the extracellular and transmembrane domains of the erythropoietin receptor and of the intracellular domain of IL-4Ralpha induces Janus kinase 1 (Jak1) activation, STAT6 activation, and Cepsilon germline transcripts in human B cell line BJAB.
1	We	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
2	show	show	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
3	that	that	SCONJ	IN	_	_	_	_	_
4	ligand	ligand	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
5	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
6	induced	induce	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
7	homodimerization	homodimerization	NOUN	NN	Number=Sing	_	_	_	_
8	of	of	ADP	IN	_	_	_	_	_
9	chimeric	chimeric	ADJ	JJ	Degree=Pos	_	_	_	_
10	surface	surface	NOUN	NN	Number=Sing	_	_	_	_
11	receptors	receptor	NOUN	NNS	Number=Plur	_	_	_	_
12	consisting	consiste	VERB	VBG	VerbForm=Ger	_	_	_	_
13	of	of	ADP	IN	_	_	_	_	_
14	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
15	extracellular	extracellular	ADJ	JJ	Degree=Pos	_	_	_	_
16	and	and	CCONJ	CC	_	_	_	_	_
17	transmembrane	transmembrane	ADJ	JJ	Degree=Pos	_	_	_	_
18	domains	domain	NOUN	NNS	Number=Plur	_	_	_	_
19	of	of	ADP	IN	_	_	_	_	_
20	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
21	erythropoietin	erythropoietin	ADJ	JJ	Degree=Pos	_	_	_	_
22	receptor	receptor	NOUN	NN	Number=Sing	_	_	_	_
23	and	and	CCONJ	CC	_	_	_	_	_
24	of	of	ADP	IN	_	_	_	_	_
25	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
26	intracellular	intracellular	ADJ	JJ	Degree=Pos	_	_	_	_
27	domain	domain	NOUN	NN	Number=Sing	_	_	_	_
28	of	of	ADP	IN	_	_	_	_	_
29	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
30	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
31	4	4	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
32	Ralpha	Ralpha	PROPN	NNP	Number=Sing	_	_	_	_
33	induces	induce	PROPN	NNPS	Number=Plur	_	_	_	_
34	Janus	Janus	PROPN	NNP	Number=Sing	_	_	_	_
35	kinase	kinase	NOUN	NN	Number=Sing	_	_	_	_
36	1	1	NUM	CD	NumType=Card	_	_	_	_
37	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
38	Jak1	Jak1	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
39	)	)	PUNCT	-RRB-	_	_	_	_	_
40	activation	activation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
41	,	,	PUNCT	,	_	_	_	_	_
42	STAT6	STAT6	NUM	CD	NumType=Card	_	_	_	_
43	activation	activation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
44	,	,	PUNCT	,	_	_	_	_	_
45	and	and	CCONJ	CC	_	_	_	_	_
46	Cepsilon	Cepsilon	PROPN	NNP	Number=Sing	_	_	_	_
47	germline	germline	NOUN	NN	Number=Sing	_	_	_	_
48	transcripts	transcript	NOUN	NNS	Number=Plur	_	_	_	_
49	in	in	ADP	IN	_	_	_	_	_
50	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
51	B	b	NOUN	NN	Number=Sing	_	_	_	_
52	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
53	line	line	NOUN	NN	Number=Sing	_	_	_	_
54	BJAB	bJAb	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
55	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1147
# text = Disruption of the Jak1-binding proline-rich Box1 region of IL-4Ralpha abolished signaling by this chimeric receptor.
1	Disruption	disruption	NOUN	NN	Number=Sing	_	_	_	_
2	of	of	ADP	IN	_	_	_	_	_
3	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
4	Jak1	Jak1	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
5	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
6	binding	bind	VERB	VBG	VerbForm=Ger	_	_	_	_
7	proline	proline	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
8	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
9	rich	rich	ADJ	JJ	Degree=Pos	_	_	_	_
10	Box1	box1	NOUN	NN	Number=Sing	_	_	_	_
11	region	region	NOUN	NN	Number=Sing	_	_	_	_
12	of	of	ADP	IN	_	_	_	_	_
13	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
14	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
15	4	for	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
16	Ralpha	Ralpha	PROPN	NNP	Number=Sing	_	_	_	_
17	abolished	abolish	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
18	signaling	signale	VERB	VBG	VerbForm=Ger	_	_	_	_
19	by	by	ADP	IN	_	_	_	_	_
20	this	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
21	chimeric	chimeric	ADJ	JJ	Degree=Pos	_	_	_	_
22	receptor	receptor	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
23	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1148
# text = Furthermore, B cells transfected with a chimeric CD8alpha/IL-4Ralpha receptor, which is expressed on the cell surface as a homodimer, constitutively expressed Cepsilon germline transcripts.
1	Furthermore	furthermore	ADV	RB	_	_	_	_	SpaceAfter=No
2	,	,	PUNCT	,	_	_	_	_	_
3	B	b	ADJ	JJ	Degree=Pos	_	_	_	_
4	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
5	transfected	transfect	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
6	with	with	ADP	IN	_	_	_	_	_
7	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
8	chimeric	chimeric	NOUN	NN	Number=Sing	_	_	_	_
9	CD8alpha/	Cd8alpha/	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
10	IL	Il	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
11	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
12	4	4	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
13	Ralpha	Ralpha	PROPN	NNP	Number=Sing	_	_	_	_
14	receptor	receptor	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
15	,	,	PUNCT	,	_	_	_	_	_
16	which	which	PRON	WDT	PronType=Rel	_	_	_	_
17	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
18	expressed	express	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
19	on	on	ADP	IN	_	_	_	_	_
20	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
21	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
22	surface	surface	NOUN	NN	Number=Sing	_	_	_	_
23	as	as	ADP	IN	_	_	_	_	_
24	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
25	homodimer	homodimer	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
26	,	,	PUNCT	,	_	_	_	_	_
27	constitutively	constitutively	ADV	RB	_	_	_	_	_
28	expressed	express	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
29	Cepsilon	Cepsilon	PROPN	NNP	Number=Sing	_	_	_	_
30	germline	germline	NOUN	NN	Number=Sing	_	_	_	_
31	transcripts	transcript	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
32	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1149
# text = These results suggest that homodimerization of the IL-4Ralpha chain is sufficient to transduce Jak1-dependent intracellular signals that lead to IgE isotype switching.
1	These	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
2	results	result	NOUN	NNS	Number=Plur	_	_	_	_
3	suggest	suggest	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
4	that	that	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
5	homodimerization	homodimerization	NOUN	NN	Number=Sing	_	_	_	_
6	of	of	ADP	IN	_	_	_	_	_
7	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
8	IL	Il	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
9	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
10	4	4	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
11	Ralpha	Ralpha	PROPN	NNP	Number=Sing	_	_	_	_
12	chain	chain	NOUN	NN	Number=Sing	_	_	_	_
13	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
14	sufficient	sufficient	ADJ	JJ	Degree=Pos	_	_	_	_
15	to	to	PART	TO	_	_	_	_	_
16	transduce	transduce	VERB	VB	VerbForm=Inf	_	_	_	_
17	Jak1	Jak1	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
18	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
19	dependent	dependent	ADJ	JJ	Degree=Pos	_	_	_	_
20	intracellular	intracellular	ADJ	JJ	Degree=Pos	_	_	_	_
21	signals	signal	NOUN	NNS	Number=Plur	_	_	_	_
22	that	that	PRON	WDT	PronType=Rel	_	_	_	_
23	lead	lead	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
24	to	to	PART	TO	_	_	_	_	_
25	IgE	Ige	VERB	VB	VerbForm=Inf	_	_	_	_
26	isotype	isotype	NOUN	NN	Number=Sing	_	_	_	_
27	switching	switch	VERB	VBG	VerbForm=Ger	_	_	_	SpaceAfter=No
28	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 1150
# text = Document 003002395 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	003002395	003002395	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 1151
# text = The class II trans-activator CIITA interacts with the TBP-associated factor TAFII32.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	class	class	NOUN	NN	Number=Sing	_	_	_	_
3	II	ii	NUM	CD	NumType=Card	_	_	_	_
4	trans	tran	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
5	-activator	-activator	NOUN	NN	Number=Sing	_	_	_	_
6	CIITA	CIITA	PROPN	NNP	Number=Sing	_	_	_	_
7	interacts	interact	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
8	with	with	ADP	IN	_	_	_	_	_
9	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
10	TBP	Tbp	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
11	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
12	associated	associate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
13	factor	factor	NOUN	NN	Number=Sing	_	_	_	_
14	TAFII32	Tafii32	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
15	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 1152
# text = The class II trans- activator (CIITA) is the main transcriptional co-activator for the expression of MHC class II proteins.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	class	class	NOUN	NN	Number=Sing	_	_	_	_
3	II	ii	NUM	CD	NumType=Card	_	_	_	_
4	trans	tran	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
5	-	-	PUNCT	:	_	_	_	_	_
6	activator	activator	NOUN	NN	Number=Sing	_	_	_	_
7	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
8	CIITA	CIITA	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
9	)	)	PUNCT	-RRB-	_	_	_	_	_
10	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
11	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
12	main	main	ADJ	JJ	Degree=Pos	_	_	_	_
13	transcriptional	transcriptional	ADJ	JJ	Degree=Pos	_	_	_	_
14	co-activator	co-activator	NOUN	NN	Number=Sing	_	_	_	_
15	for	for	ADP	IN	_	_	_	_	_
16	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
17	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
18	of	of	ADP	IN	_	_	_	_	_
19	MHC	MHC	PROPN	NNP	Number=Sing	_	_	_	_
20	class	class	NOUN	NN	Number=Sing	_	_	_	_
21	II	ii	NUM	CD	NumType=Card	_	_	_	_
22	proteins	protein	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
23	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1153
# text = Its N-terminal 125 amino acids function as an independent transcriptional activation domain.
1	Its	its	PRON	PRP$	Gender=Neut|Number=Sing|Person=3|Poss=Yes|PronType=Prs	_	_	_	_
2	N-	N-	SYM	NFP	_	_	_	_	SpaceAfter=No
3	terminal	terminal	ADJ	JJ	Degree=Pos	_	_	_	_
4	125	125	NUM	CD	NumType=Card	_	_	_	_
5	amino	amino	ADJ	JJ	Degree=Pos	_	_	_	_
6	acids	acids	NOUN	NNS	Number=Plur	_	_	_	_
7	function	function	NOUN	NN	Number=Sing	_	_	_	_
8	as	as	ADP	IN	_	_	_	_	_
9	an	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
10	independent	independent	ADJ	JJ	Degree=Pos	_	_	_	_
11	transcriptional	transcriptional	ADJ	JJ	Degree=Pos	_	_	_	_
12	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
13	domain	domain	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
14	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1154
# text = Analyses of the primary amino acid sequence of the activation domain predict the presence of three alpha-helices, each with a high proportion of acidic residues.
1	Analyses	analysis	NOUN	NNS	Number=Plur	_	_	_	_
2	of	of	ADP	IN	_	_	_	_	_
3	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
4	primary	primary	ADJ	JJ	Degree=Pos	_	_	_	_
5	amino	amino	X	GW	_	_	_	_	_
6	acid	acid	ADJ	JJ	Degree=Pos	_	_	_	_
7	sequence	sequence	NOUN	NN	Number=Sing	_	_	_	_
8	of	of	ADP	IN	_	_	_	_	_
9	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
10	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
11	domain	domain	NOUN	NN	Number=Sing	_	_	_	_
12	predict	predict	VERB	VB	VerbForm=Inf	_	_	_	_
13	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
14	presence	presence	NOUN	NN	Number=Sing	_	_	_	_
15	of	of	ADP	IN	_	_	_	_	_
16	three	three	NUM	CD	NumType=Card	_	_	_	_
17	alpha	alpha	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
18	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
19	helices	helice	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
20	,	,	PUNCT	,	_	_	_	_	_
21	each	each	DET	DT	_	_	_	_	_
22	with	with	ADP	IN	_	_	_	_	_
23	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
24	high	high	ADJ	JJ	Degree=Pos	_	_	_	_
25	proportion	proportion	NOUN	NN	Number=Sing	_	_	_	_
26	of	of	ADP	IN	_	_	_	_	_
27	acidic	acidic	ADJ	JJ	Degree=Pos	_	_	_	_
28	residues	residue	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
29	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1155
# text = Using site-directed mutagenesis, we found that two of these predicted alpha-helices are required for full transcriptional activation by CIITA.
1	Using	use	VERB	VBG	VerbForm=Ger	_	_	_	_
2	site	site	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
3	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
4	directed	direct	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
5	mutagenesis	mutagenesis	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
6	,	,	PUNCT	,	_	_	_	_	_
7	we	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
8	found	find	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
9	that	that	SCONJ	IN	_	_	_	_	_
10	two	two	NUM	CD	NumType=Card	_	_	_	_
11	of	of	ADP	IN	_	_	_	_	_
12	these	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
13	predicted	predict	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
14	alpha	alpha	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
15	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
16	helices	helice	NOUN	NNS	Number=Plur	_	_	_	_
17	are	be	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
18	required	require	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
19	for	for	ADP	IN	_	_	_	_	_
20	full	full	ADJ	JJ	Degree=Pos	_	_	_	_
21	transcriptional	transcriptional	ADJ	JJ	Degree=Pos	_	_	_	_
22	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
23	by	by	ADP	IN	_	_	_	_	_
24	CIITA	CIITA	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
25	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1156
# text = Moreover, a CIITA protein in which both functional alpha-helices have been deleted displays a dominant negative phenotype.
1	Moreover	moreover	ADV	RB	_	_	_	_	SpaceAfter=No
2	,	,	PUNCT	,	_	_	_	_	_
3	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
4	CIITA	CIITA	PROPN	NNP	Number=Sing	_	_	_	_
5	protein	protein	NOUN	NN	Number=Sing	_	_	_	_
6	in	in	ADP	IN	_	_	_	_	_
7	which	which	PRON	WDT	PronType=Rel	_	_	_	_
8	both	both	DET	DT	_	_	_	_	_
9	functional	functional	ADJ	JJ	Degree=Pos	_	_	_	_
10	alpha	alpha	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
11	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
12	helices	helice	NOUN	NNS	Number=Plur	_	_	_	_
13	have	have	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
14	been	be	AUX	VBN	Tense=Past|VerbForm=Part	_	_	_	_
15	deleted	delete	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
16	displays	display	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
17	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
18	dominant	dominant	ADJ	JJ	Degree=Pos	_	_	_	_
19	negative	negative	ADJ	JJ	Degree=Pos	_	_	_	_
20	phenotype	phenotype	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
21	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1157
# text = This activation domain of CIITA interacts with the 32 kDa subunit of the general transcription complex TFIID, TAFII32.
1	This	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
2	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
3	domain	domain	NOUN	NN	Number=Sing	_	_	_	_
4	of	of	ADP	IN	_	_	_	_	_
5	CIITA	CIITA	PROPN	NNP	Number=Sing	_	_	_	_
6	interacts	interact	NOUN	NNS	Number=Plur	_	_	_	_
7	with	with	ADP	IN	_	_	_	_	_
8	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
9	32	32	NUM	CD	NumType=Card	_	_	_	_
10	kDa	kDa	NOUN	NN	Number=Sing	_	_	_	_
11	subunit	subunit	NOUN	NN	Number=Sing	_	_	_	_
12	of	of	ADP	IN	_	_	_	_	_
13	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
14	general	general	ADJ	JJ	Degree=Pos	_	_	_	_
15	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
16	complex	complex	NOUN	NN	Number=Sing	_	_	_	_
17	TFIID	tFIId	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
18	,	,	PUNCT	,	_	_	_	_	_
19	TAFII32	TAFII32	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
20	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1158
# text = Decreased transcriptional activation by N-terminal deletions of CIITA is correlated directly with their reduced binding to TAFII32.
1	Decreased	Decrease	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
2	transcriptional	transcriptional	ADJ	JJ	Degree=Pos	_	_	_	_
3	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
4	by	by	ADP	IN	_	_	_	_	_
5	N-	N-	SYM	NFP	_	_	_	_	SpaceAfter=No
6	terminal	terminal	ADJ	JJ	Degree=Pos	_	_	_	_
7	deletions	deletion	NOUN	NNS	Number=Plur	_	_	_	_
8	of	of	ADP	IN	_	_	_	_	_
9	CIITA	CIITA	PROPN	NNP	Number=Sing	_	_	_	_
10	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
11	correlated	correlate	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
12	directly	directly	ADV	RB	_	_	_	_	_
13	with	with	ADP	IN	_	_	_	_	_
14	their	they	PRON	PRP$	Number=Plur|Person=3|Poss=Yes|PronType=Prs	_	_	_	_
15	reduced	reduce	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
16	binding	bind	VERB	VBG	VerbForm=Ger	_	_	_	_
17	to	to	ADP	IN	_	_	_	_	_
18	TAFII32	Tafii32	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
19	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1159
# text = We conclude that interactions between TAFII32 and CIITA are responsible for activation of class II genes.
1	We	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
2	conclude	conclude	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
3	that	that	SCONJ	IN	_	_	_	_	_
4	interactions	interaction	NOUN	NNS	Number=Plur	_	_	_	_
5	between	between	ADP	IN	_	_	_	_	_
6	TAFII32	Tafii32	NOUN	NN	Number=Sing	_	_	_	_
7	and	and	CCONJ	CC	_	_	_	_	_
8	CIITA	CIITa	NOUN	NN	Number=Sing	_	_	_	_
9	are	be	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
10	responsible	responsible	ADJ	JJ	Degree=Pos	_	_	_	_
11	for	for	ADP	IN	_	_	_	_	_
12	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
13	of	of	ADP	IN	_	_	_	_	_
14	class	class	NOUN	NN	Number=Sing	_	_	_	_
15	II	ii	NUM	CD	NumType=Card	_	_	_	_
16	genes	gene	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
17	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 1160
# text = Document 003002398 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	003002398	003002398	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 1161
# text = Transcriptional regulation of the interleukin-2 gene in normal human peripheral blood T cells.
1	Transcriptional	Transcriptional	ADJ	JJ	Degree=Pos	_	_	_	_
2	regulation	regulation	NOUN	NN	Number=Sing	_	_	_	_
3	of	of	ADP	IN	_	_	_	_	_
4	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
5	interleukin	interleukin	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
6	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
7	2	2	NUM	CD	NumType=Card	_	_	_	_
8	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
9	in	in	ADP	IN	_	_	_	_	_
10	normal	normal	ADJ	JJ	Degree=Pos	_	_	_	_
11	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
12	peripheral	peripheral	ADJ	JJ	Degree=Pos	_	_	_	_
13	blood	blood	NOUN	NN	Number=Sing	_	_	_	_
14	T	t	PROPN	NNP	Number=Sing	_	_	_	_
15	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
16	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1162
# text = Convergence of costimulatory signals and differences from transformed T cells.
1	Convergence	Convergence	NOUN	NN	Number=Sing	_	_	_	_
2	of	of	ADP	IN	_	_	_	_	_
3	costimulatory	costimulatory	ADJ	JJ	Degree=Pos	_	_	_	_
4	signals	signal	NOUN	NNS	Number=Plur	_	_	_	_
5	and	and	CCONJ	CC	_	_	_	_	_
6	differences	difference	NOUN	NNS	Number=Plur	_	_	_	_
7	from	from	ADP	IN	_	_	_	_	_
8	transformed	transform	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
9	T	t	PROPN	NNP	Number=Sing	_	_	_	_
10	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
11	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 1163
# text = To study transcriptional regulation in normal human T cells, we have optimized conditions for transient transfection.
1	To	to	PART	TO	_	_	_	_	_
2	study	study	VERB	VB	VerbForm=Inf	_	_	_	_
3	transcriptional	transcriptional	ADJ	JJ	Degree=Pos	_	_	_	_
4	regulation	regulation	NOUN	NN	Number=Sing	_	_	_	_
5	in	in	ADP	IN	_	_	_	_	_
6	normal	normal	ADJ	JJ	Degree=Pos	_	_	_	_
7	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
8	T	t	NOUN	NN	Number=Sing	_	_	_	_
9	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
10	,	,	PUNCT	,	_	_	_	_	_
11	we	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
12	have	have	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
13	optimized	optimize	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
14	conditions	condition	NOUN	NNS	Number=Plur	_	_	_	_
15	for	for	ADP	IN	_	_	_	_	_
16	transient	transient	ADJ	JJ	Degree=Pos	_	_	_	_
17	transfection	transfection	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
18	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1164
# text = Interleukin-2 (IL-2) promoter-reporter gene behavior closely parallels the endogenous gene in response to T cell receptor and costimulatory signals.
1	Interleukin	Interleukin	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
2	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
3	2	2	NUM	CD	NumType=Card	_	_	_	_
4	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
5	IL	Il	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
6	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
7	2	2	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
8	)	)	PUNCT	-RRB-	_	_	_	_	_
9	promoter	promoter	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
10	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
11	reporter	reporter	NOUN	NN	Number=Sing	_	_	_	_
12	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
13	behavior	behavior	NOUN	NN	Number=Sing	_	_	_	_
14	closely	closely	ADV	RB	_	_	_	_	_
15	parallels	parallel	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
16	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
17	endogenous	endogenous	ADJ	JJ	Degree=Pos	_	_	_	_
18	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
19	in	in	ADP	IN	_	_	_	_	_
20	response	response	NOUN	NN	Number=Sing	_	_	_	_
21	to	to	PART	TO	_	_	_	_	_
22	T	t	VERB	VB	VerbForm=Inf	_	_	_	_
23	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
24	receptor	receptor	NOUN	NN	Number=Sing	_	_	_	_
25	and	and	CCONJ	CC	_	_	_	_	_
26	costimulatory	costimulatory	ADJ	JJ	Degree=Pos	_	_	_	_
27	signals	signal	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
28	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1165
# text = As assessed with mutagenized promoters, the most important IL-2 cis-regulatory elements in normal T cells are the proximal AP-1 site and the NF- kappaB site.
1	As	as	SCONJ	IN	_	_	_	_	_
2	assessed	assess	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
3	with	with	ADP	IN	_	_	_	_	_
4	mutagenized	mutagenize	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
5	promoters	promoter	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
6	,	,	PUNCT	,	_	_	_	_	_
7	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
8	most	most	ADV	RBS	_	_	_	_	_
9	important	important	ADJ	JJ	Degree=Pos	_	_	_	_
10	IL	Il	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
11	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
12	2	2	NUM	CD	NumType=Card	_	_	_	_
13	cis	cis	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
14	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
15	regulatory	regulatory	ADJ	JJ	Degree=Pos	_	_	_	_
16	elements	element	NOUN	NNS	Number=Plur	_	_	_	_
17	in	in	ADP	IN	_	_	_	_	_
18	normal	normal	ADJ	JJ	Degree=Pos	_	_	_	_
19	T	t	PROPN	NNP	Number=Sing	_	_	_	_
20	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
21	are	be	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
22	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
23	proximal	proximal	ADJ	JJ	Degree=Pos	_	_	_	_
24	AP	ap	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
25	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
26	1	1	NUM	CD	NumType=Card	_	_	_	_
27	site	site	NOUN	NN	Number=Sing	_	_	_	_
28	and	and	CCONJ	CC	_	_	_	_	_
29	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
30	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
31	-	-	PUNCT	HYPH	_	_	_	_	_
32	kappaB	kappaB	PROPN	NNP	Number=Sing	_	_	_	_
33	site	site	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
34	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1166
# text = Both primary activation, with phytohemagglutinin or antibodies to CD3, and costimulation, provided by pairs of CD2 antibodies or B7-positive (B cells) or B7-negative (endothelial) accessory cells, are mediated through the same cis-elements.
1	Both	both	DET	DT	_	_	_	_	_
2	primary	primary	ADJ	JJ	Degree=Pos	_	_	_	_
3	activation	activation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
4	,	,	PUNCT	,	_	_	_	_	_
5	with	with	ADP	IN	_	_	_	_	_
6	phytohemagglutinin	phytohemagglutinin	NOUN	NN	Number=Sing	_	_	_	_
7	or	or	CCONJ	CC	_	_	_	_	_
8	antibodies	antibody	NOUN	NNS	Number=Plur	_	_	_	_
9	to	to	ADP	IN	_	_	_	_	_
10	CD3	CD3	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
11	,	,	PUNCT	,	_	_	_	_	_
12	and	and	CCONJ	CC	_	_	_	_	_
13	costimulation	costimulation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
14	,	,	PUNCT	,	_	_	_	_	_
15	provided	provide	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
16	by	by	ADP	IN	_	_	_	_	_
17	pairs	pair	NOUN	NNS	Number=Plur	_	_	_	_
18	of	of	ADP	IN	_	_	_	_	_
19	CD2	CD2	NOUN	NN	Number=Sing	_	_	_	_
20	antibodies	antibody	NOUN	NNS	Number=Plur	_	_	_	_
21	or	or	CCONJ	CC	_	_	_	_	_
22	B7	B7	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
23	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
24	positive	positive	ADJ	JJ	Degree=Pos	_	_	_	_
25	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
26	B	b	ADJ	JJ	Degree=Pos	_	_	_	_
27	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
28	)	)	PUNCT	-RRB-	_	_	_	_	_
29	or	or	CCONJ	CC	_	_	_	_	_
30	B7	B7	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
31	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
32	negative	negative	ADJ	JJ	Degree=Pos	_	_	_	_
33	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
34	endothelial	endothelial	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
35	)	)	PUNCT	-RRB-	_	_	_	_	_
36	accessory	accessory	ADJ	JJ	Degree=Pos	_	_	_	_
37	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
38	,	,	PUNCT	,	_	_	_	_	_
39	are	be	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
40	mediated	mediate	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
41	through	through	ADP	IN	_	_	_	_	_
42	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
43	same	same	ADJ	JJ	Degree=Pos	_	_	_	_
44	cis	cis	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
45	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
46	elements	element	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
47	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1167
# text = Interestingly, the nuclear factor of activated T cell sites are much less important in normal T cells than in Jurkat T cells.
1	Interestingly	Interestingly	ADV	RB	_	_	_	_	SpaceAfter=No
2	,	,	PUNCT	,	_	_	_	_	_
3	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
4	nuclear	nuclear	ADJ	JJ	Degree=Pos	_	_	_	_
5	factor	factor	NOUN	NN	Number=Sing	_	_	_	_
6	of	of	ADP	IN	_	_	_	_	_
7	activated	activate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
8	T	t	PROPN	NNP	Number=Sing	_	_	_	_
9	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
10	sites	site	NOUN	NNS	Number=Plur	_	_	_	_
11	are	be	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
12	much	much	ADV	RB	_	_	_	_	_
13	less	less	ADV	RBR	Degree=Cmp	_	_	_	_
14	important	important	ADJ	JJ	Degree=Pos	_	_	_	_
15	in	in	ADP	IN	_	_	_	_	_
16	normal	normal	ADJ	JJ	Degree=Pos	_	_	_	_
17	T	t	PROPN	NNP	Number=Sing	_	_	_	_
18	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
19	than	than	ADP	IN	_	_	_	_	_
20	in	in	ADP	IN	_	_	_	_	_
21	Jurkat	Jurkat	PROPN	NNP	Number=Sing	_	_	_	_
22	T	t	PROPN	NNP	Number=Sing	_	_	_	_
23	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
24	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1168
# text = We conclude that IL-2 transcriptional regulation differs in tumor cell lines compared with normal T cells and that different costimulatory signals converge on the same cis-elements in the IL-2 promoter.
1	We	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
2	conclude	conclude	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
3	that	that	SCONJ	IN	_	_	_	_	_
4	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
5	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
6	2	2	NUM	CD	NumType=Card	_	_	_	_
7	transcriptional	transcriptional	ADJ	JJ	Degree=Pos	_	_	_	_
8	regulation	regulation	NOUN	NN	Number=Sing	_	_	_	_
9	differs	differ	NOUN	NNS	Number=Plur	_	_	_	_
10	in	in	ADP	IN	_	_	_	_	_
11	tumor	tumor	NOUN	NN	Number=Sing	_	_	_	_
12	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
13	lines	line	NOUN	NNS	Number=Plur	_	_	_	_
14	compared	compare	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
15	with	with	ADP	IN	_	_	_	_	_
16	normal	normal	ADJ	JJ	Degree=Pos	_	_	_	_
17	T	t	PROPN	NNP	Number=Sing	_	_	_	_
18	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
19	and	and	CCONJ	CC	_	_	_	_	_
20	that	that	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
21	different	different	ADJ	JJ	Degree=Pos	_	_	_	_
22	costimulatory	costimulatory	NOUN	NN	Number=Sing	_	_	_	_
23	signals	signal	NOUN	NNS	Number=Plur	_	_	_	_
24	converge	converge	NOUN	NN	Number=Sing	_	_	_	_
25	on	on	ADP	IN	_	_	_	_	_
26	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
27	same	same	ADJ	JJ	Degree=Pos	_	_	_	_
28	cis	cis	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
29	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
30	elements	element	NOUN	NNS	Number=Plur	_	_	_	_
31	in	in	ADP	IN	_	_	_	_	_
32	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
33	IL	Il	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
34	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
35	2	2	NUM	CD	NumType=Card	_	_	_	_
36	promoter	promoter	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
37	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 1169
# text = Document 003002407 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	003002407	003002407	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 1170
# text = IL-2-mediated cell cycle progression and inhibition of apoptosis does not require NF-kappa B or activating protein-1 activation in primary human T cells.
1	IL	Il	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
2	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
3	2	2	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
4	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
5	mediated	mediate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
6	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
7	cycle	cycle	NOUN	NN	Number=Sing	_	_	_	_
8	progression	progression	NOUN	NN	Number=Sing	_	_	_	_
9	and	and	CCONJ	CC	_	_	_	_	_
10	inhibition	inhibition	NOUN	NN	Number=Sing	_	_	_	_
11	of	of	ADP	IN	_	_	_	_	_
12	apoptosis	apoptosis	PRON	DT	Number=Sing|PronType=Dem	_	_	_	_
13	does	do	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
14	not	not	PART	RB	_	_	_	_	_
15	require	require	VERB	VB	VerbForm=Inf	_	_	_	_
16	NF	Nf	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
17	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
18	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_
19	B	b	NOUN	NN	Number=Sing	_	_	_	_
20	or	or	CCONJ	CC	_	_	_	_	_
21	activating	activate	VERB	VBG	VerbForm=Ger	_	_	_	_
22	protein	protein	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
23	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
24	1	1	NUM	CD	NumType=Card	_	_	_	_
25	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
26	in	in	ADP	IN	_	_	_	_	_
27	primary	primary	ADJ	JJ	Degree=Pos	_	_	_	_
28	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
29	T	t	PROPN	NNP	Number=Sing	_	_	_	_
30	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
31	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 1171
# text = The IL-2 growth hormone is the major growth factor of activated T lymphocytes during a developing immune response.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	IL	Il	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
3	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
4	2	2	NUM	CD	NumType=Card	_	_	_	_
5	growth	growth	NOUN	NN	Number=Sing	_	_	_	_
6	hormone	hormone	NOUN	NN	Number=Sing	_	_	_	_
7	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
8	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
9	major	major	ADJ	JJ	Degree=Pos	_	_	_	_
10	growth	growth	NOUN	NN	Number=Sing	_	_	_	_
11	factor	factor	NOUN	NN	Number=Sing	_	_	_	_
12	of	of	ADP	IN	_	_	_	_	_
13	activated	activate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
14	T	t	PROPN	NNP	Number=Sing	_	_	_	_
15	lymphocytes	lymphocyte	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
16	during	during	ADP	IN	_	_	_	_	_
17	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
18	developing	develop	VERB	VBG	VerbForm=Ger	_	_	_	_
19	immune	immune	ADJ	JJ	Degree=Pos	_	_	_	_
20	response	response	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
21	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1172
# text = IL-2 is required not only for cell cycle progression but also to protect
1	IL	Il	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
2	-	-	PUNCT	:	_	_	_	_	SpaceAfter=No
3	2	2	NUM	CD	NumType=Card	_	_	_	_
4	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
5	required	require	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
6	not	not	ADV	RB	_	_	_	_	_
7	only	only	ADV	RB	_	_	_	_	_
8	for	for	ADP	IN	_	_	_	_	_
9	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
10	cycle	cycle	NOUN	NN	Number=Sing	_	_	_	_
11	progression	progression	NOUN	NN	Number=Sing	_	_	_	_
12	but	but	CCONJ	CC	_	_	_	_	_
13	also	also	ADV	RB	_	_	_	_	_
14	to	to	PART	TO	_	_	_	_	_
15	protect	protect	VERB	VB	VerbForm=Inf	_	_	_	_

# sent_id = 1173
# text = Ag-activated T cells from programmed cell death.
1	Ag-	Ag-	SYM	NFP	_	_	_	_	SpaceAfter=No
2	activated	activate	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
3	T	t	PROPN	NNP	Number=Sing	_	_	_	_
4	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
5	from	from	ADP	IN	_	_	_	_	_
6	programmed	program	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
7	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
8	death	death	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
9	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1174
# text = In several cell types, activation of NF-kappa B and/or activating protein-1 (AP-1) has been demonstrated to be extremely important in blocking apoptosis.
1	In	in	ADP	IN	_	_	_	_	_
2	several	several	ADJ	JJ	Degree=Pos	_	_	_	_
3	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
4	types	type	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
5	,	,	PUNCT	,	_	_	_	_	_
6	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
7	of	of	ADP	IN	_	_	_	_	_
8	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
9	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
10	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_
11	B	b	NOUN	NN	Number=Sing	_	_	_	_
12	and	and	CCONJ	CC	_	_	_	_	SpaceAfter=No
13	/	/	PUNCT	,	_	_	_	_	SpaceAfter=No
14	or	or	CCONJ	CC	_	_	_	_	_
15	activating	activate	VERB	VBG	VerbForm=Ger	_	_	_	_
16	protein	protein	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
17	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
18	1	1	NUM	CD	NumType=Card	_	_	_	_
19	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
20	AP	ap	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
21	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
22	1	1	X	LS	_	_	_	_	SpaceAfter=No
23	)	)	PUNCT	-RRB-	_	_	_	_	_
24	has	have	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
25	been	be	AUX	VBN	Tense=Past|VerbForm=Part	_	_	_	_
26	demonstrated	demonstrate	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
27	to	to	PART	TO	_	_	_	_	_
28	be	be	AUX	VB	VerbForm=Inf	_	_	_	_
29	extremely	extremely	ADV	RB	_	_	_	_	_
30	important	important	ADJ	JJ	Degree=Pos	_	_	_	_
31	in	in	SCONJ	IN	_	_	_	_	_
32	blocking	block	VERB	VBG	VerbForm=Ger	_	_	_	_
33	apoptosis	apoptosis	PRON	DT	Number=Sing|PronType=Dem	_	_	_	SpaceAfter=No
34	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1175
# text = To determine whether either or both of these transcription factors are involved in cell survival or cell cycle progression in response to IL-2, primary human T cells responsive to the growth factor were analyzed for NF-kappa B and AP-1 activation.
1	To	to	PART	TO	_	_	_	_	_
2	determine	determine	VERB	VB	VerbForm=Inf	_	_	_	_
3	whether	whether	SCONJ	IN	_	_	_	_	_
4	either	either	DET	DT	_	_	_	_	_
5	or	or	CCONJ	CC	_	_	_	_	_
6	both	both	DET	DT	_	_	_	_	_
7	of	of	ADP	IN	_	_	_	_	_
8	these	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
9	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
10	factors	factor	NOUN	NNS	Number=Plur	_	_	_	_
11	are	be	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
12	involved	involved	ADJ	JJ	Degree=Pos	_	_	_	_
13	in	in	ADP	IN	_	_	_	_	_
14	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
15	survival	survival	NOUN	NN	Number=Sing	_	_	_	_
16	or	or	CCONJ	CC	_	_	_	_	_
17	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
18	cycle	cycle	NOUN	NN	Number=Sing	_	_	_	_
19	progression	progression	NOUN	NN	Number=Sing	_	_	_	_
20	in	in	ADP	IN	_	_	_	_	_
21	response	response	NOUN	NN	Number=Sing	_	_	_	_
22	to	to	ADP	IN	_	_	_	_	_
23	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
24	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
25	2	2	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
26	,	,	PUNCT	,	_	_	_	_	_
27	primary	primary	ADJ	JJ	Degree=Pos	_	_	_	_
28	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
29	T	t	NOUN	NN	Number=Sing	_	_	_	_
30	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
31	responsive	responsive	ADJ	JJ	Degree=Pos	_	_	_	_
32	to	to	ADP	IN	_	_	_	_	_
33	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
34	growth	growth	NOUN	NN	Number=Sing	_	_	_	_
35	factor	factor	NOUN	NN	Number=Sing	_	_	_	_
36	were	be	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
37	analyzed	analyze	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
38	for	for	ADP	IN	_	_	_	_	_
39	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
40	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
41	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_
42	B	b	NOUN	NN	Number=Sing	_	_	_	_
43	and	and	CCONJ	CC	_	_	_	_	_
44	AP	ap	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
45	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
46	1	1	NUM	CD	NumType=Card	_	_	_	_
47	activation	activation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
48	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1176
# text = The current study clearly demonstrates that IL-2 does not induce I kappa B alpha degradation or NF-kappa B activation in primary human T cells that respond to IL-2 by entering the cell cycle and avoiding apoptosis.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	current	current	ADJ	JJ	Degree=Pos	_	_	_	_
3	study	study	NOUN	NN	Number=Sing	_	_	_	_
4	clearly	clearly	ADV	RB	_	_	_	_	_
5	demonstrates	demonstrate	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
6	that	that	SCONJ	IN	_	_	_	_	_
7	IL	Il	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
8	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
9	2	2	NUM	CD	NumType=Card	_	_	_	_
10	does	do	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
11	not	not	PART	RB	_	_	_	_	_
12	induce	induce	VERB	VB	VerbForm=Inf	_	_	_	_
13	I	I	PRON	PRP	Case=Nom|Number=Sing|Person=1|PronType=Prs	_	_	_	_
14	kappa	kappa	X	FW	Foreign=Yes	_	_	_	_
15	B	b	ADJ	JJ	Degree=Pos	_	_	_	_
16	alpha	alpha	NOUN	NN	Number=Sing	_	_	_	_
17	degradation	degradation	NOUN	NN	Number=Sing	_	_	_	_
18	or	or	CCONJ	CC	_	_	_	_	_
19	NF	Nf	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
20	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
21	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_
22	B	b	NOUN	NN	Number=Sing	_	_	_	_
23	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
24	in	in	ADP	IN	_	_	_	_	_
25	primary	primary	ADJ	JJ	Degree=Pos	_	_	_	_
26	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
27	T	t	NOUN	NN	Number=Sing	_	_	_	_
28	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
29	that	that	PRON	WDT	PronType=Rel	_	_	_	_
30	respond	respond	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
31	to	to	ADP	IN	_	_	_	_	_
32	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
33	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
34	2	2	NUM	CD	NumType=Card	_	_	_	_
35	by	by	SCONJ	IN	_	_	_	_	_
36	entering	enter	VERB	VBG	VerbForm=Ger	_	_	_	_
37	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
38	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
39	cycle	cycle	NOUN	NN	Number=Sing	_	_	_	_
40	and	and	CCONJ	CC	_	_	_	_	_
41	avoiding	avoid	VERB	VBG	VerbForm=Ger	_	_	_	_
42	apoptosis	apoptosis	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
43	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1177
# text = Similarly, IL-2 neither activates JNK nor increases AP-1 binding activity to a consensus o-tetradecanoylphorbol 13-acetate (TPA) response element.
1	Similarly	similarly	ADV	RB	_	_	_	_	SpaceAfter=No
2	,	,	PUNCT	,	_	_	_	_	_
3	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
4	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
5	2	2	NUM	CD	NumType=Card	_	_	_	_
6	neither	neither	NOUN	NN	Number=Sing	_	_	_	_
7	activates	activate	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
8	JNK	Jnk	PROPN	NNP	Number=Sing	_	_	_	_
9	nor	nor	CCONJ	CC	_	_	_	_	_
10	increases	increase	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
11	AP	ap	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
12	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
13	1	1	NUM	CD	NumType=Card	_	_	_	_
14	binding	binding	VERB	VBG	VerbForm=Ger	_	_	_	_
15	activity	activity	NOUN	NN	Number=Sing	_	_	_	_
16	to	to	ADP	IN	_	_	_	_	_
17	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
18	consensus	consensus	NOUN	NN	Number=Sing	_	_	_	_
19	o-	o-	PUNCT	,	_	_	_	_	SpaceAfter=No
20	tetradecanoylphorbol	tetradecanoylphorbol	NOUN	NN	Number=Sing	_	_	_	_
21	13	13	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
22	-	-	PUNCT	:	_	_	_	_	SpaceAfter=No
23	acetate	acetate	NOUN	NN	Number=Sing	_	_	_	_
24	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
25	TPA	TPA	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
26	)	)	PUNCT	-RRB-	_	_	_	_	_
27	response	response	NOUN	NN	Number=Sing	_	_	_	_
28	element	element	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
29	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1178
# text = On the other hand, the growth factor does induce the activation of STAT3 and STAT5 in these cells, as has been previously demonstrated.
1	On	on	ADP	IN	_	_	_	_	_
2	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
3	other	other	ADJ	JJ	Degree=Pos	_	_	_	_
4	hand	hand	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
5	,	,	PUNCT	,	_	_	_	_	_
6	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
7	growth	growth	NOUN	NN	Number=Sing	_	_	_	_
8	factor	factor	NOUN	NN	Number=Sing	_	_	_	_
9	does	do	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
10	induce	induce	VERB	VB	VerbForm=Inf	_	_	_	_
11	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
12	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
13	of	of	ADP	IN	_	_	_	_	_
14	STAT3	STAT3	NOUN	NN	Number=Sing	_	_	_	_
15	and	and	CCONJ	CC	_	_	_	_	_
16	STAT5	STAT5	NOUN	NN	Number=Sing	_	_	_	_
17	in	in	ADP	IN	_	_	_	_	_
18	these	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
19	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
20	,	,	PUNCT	,	_	_	_	_	_
21	as	as	SCONJ	IN	_	_	_	_	_
22	has	have	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
23	been	be	AUX	VBN	Tense=Past|VerbForm=Part	_	_	_	_
24	previously	previously	ADV	RB	_	_	_	_	_
25	demonstrated	demonstrate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	SpaceAfter=No
26	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1179
# text = These data show that neither NF-kappa B nor AP-1 activation is required for IL-2-mediated survival or cell cycle progression in activated primary human T cells.
1	These	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
2	data	data	NOUN	NN	Number=Sing	_	_	_	_
3	show	show	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
4	that	that	SCONJ	IN	_	_	_	_	_
5	neither	neither	DET	DT	_	_	_	_	_
6	NF	Nf	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
7	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
8	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_
9	B	b	NOUN	NN	Number=Sing	_	_	_	_
10	nor	nor	CCONJ	CC	_	_	_	_	_
11	AP	ap	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
12	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
13	1	1	NUM	CD	NumType=Card	_	_	_	_
14	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
15	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
16	required	require	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
17	for	for	ADP	IN	_	_	_	_	_
18	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
19	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
20	2	2	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
21	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
22	mediated	mediate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
23	survival	survival	NOUN	NN	Number=Sing	_	_	_	_
24	or	or	CCONJ	CC	_	_	_	_	_
25	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
26	cycle	cycle	NOUN	NN	Number=Sing	_	_	_	_
27	progression	progression	NOUN	NN	Number=Sing	_	_	_	_
28	in	in	ADP	IN	_	_	_	_	_
29	activated	activated	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
30	primary	primary	ADJ	JJ	Degree=Pos	_	_	_	_
31	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
32	T	t	PROPN	NNP	Number=Sing	_	_	_	_
33	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
34	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 1180
# text = Document 003002409 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	003002409	003002409	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 1181
# text = Transcription factor
1	Transcription	Transcription	NOUN	NN	Number=Sing	_	_	_	_
2	factor	factor	NOUN	NN	Number=Sing	_	_	_	_

# sent_id = 1182
# text = NF-kappaB regulates inducible Oct-2 gene expression in precursor B lymphocytes.
1	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
2	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
3	kappaB	kappaB	PROPN	NNP	Number=Sing	_	_	_	_
4	regulates	regulate	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
5	inducible	inducible	ADJ	JJ	Degree=Pos	_	_	_	_
6	Oct	Oct	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
7	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
8	2	2	NUM	CD	NumType=Card	_	_	_	_
9	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
10	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
11	in	in	ADP	IN	_	_	_	_	_
12	precursor	precursor	ADJ	JJ	Degree=Pos	_	_	_	_
13	B	b	NOUN	NN	Number=Sing	_	_	_	_
14	lymphocytes	lymphocyte	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
15	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 1183
# text = The POU transcription factors Oct-1 and Oct-2 regulate the activity of octamer-dependent promoters, including those that direct transcription from rearranged immunoglobulin genes.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	POU	pou	NOUN	NN	Number=Sing	_	_	_	_
3	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
4	factors	factor	NOUN	NNS	Number=Plur	_	_	_	_
5	Oct	Oct	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
6	-1	-1	NUM	CD	NumType=Card	_	_	_	_
7	and	and	CCONJ	CC	_	_	_	_	_
8	Oct	Oct	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
9	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
10	2	to	NUM	CD	NumType=Card	_	_	_	_
11	regulate	regulate	VERB	VB	VerbForm=Inf	_	_	_	_
12	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
13	activity	activity	NOUN	NN	Number=Sing	_	_	_	_
14	of	of	ADP	IN	_	_	_	_	_
15	octamer	octamer	ADV	RB	_	_	_	_	SpaceAfter=No
16	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
17	dependent	dependent	ADJ	JJ	Degree=Pos	_	_	_	_
18	promoters	promoter	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
19	,	,	PUNCT	,	_	_	_	_	_
20	including	include	VERB	VBG	VerbForm=Ger	_	_	_	_
21	those	those	PRON	DT	Number=Plur|PronType=Dem	_	_	_	_
22	that	that	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
23	direct	direct	ADJ	JJ	Degree=Pos	_	_	_	_
24	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
25	from	from	ADP	IN	_	_	_	_	_
26	rearranged	rearrange	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
27	immunoglobulin	immunoglobulin	ADJ	JJ	Degree=Pos	_	_	_	_
28	genes	gene	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
29	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1184
# text = Unlike Oct-1, which is constitutively expressed in many cell types, Oct-2 expression is restricted primarily to B lymphocytes and can be induced in precursor B cells by stimulation with bacterial lipopolysaccharide (LPS).
1	Unlike	unlike	ADP	IN	_	_	_	_	_
2	Oct	Oct	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
3	-1	-1	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
4	,	,	PUNCT	,	_	_	_	_	_
5	which	which	PRON	WDT	PronType=Rel	_	_	_	_
6	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
7	constitutively	constitutively	ADV	RB	_	_	_	_	_
8	expressed	express	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
9	in	in	ADP	IN	_	_	_	_	_
10	many	many	ADJ	JJ	Degree=Pos	_	_	_	_
11	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
12	types	type	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
13	,	,	PUNCT	,	_	_	_	_	_
14	Oct	Oct	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
15	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
16	2	2	NUM	CD	NumType=Card	_	_	_	_
17	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
18	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
19	restricted	restrict	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
20	primarily	primarily	ADV	RB	_	_	_	_	_
21	to	to	ADP	IN	_	_	_	_	_
22	B	b	ADJ	JJ	Degree=Pos	_	_	_	_
23	lymphocytes	lymphocyte	NOUN	NNS	Number=Plur	_	_	_	_
24	and	and	CCONJ	CC	_	_	_	_	_
25	can	can	AUX	MD	VerbForm=Fin	_	_	_	_
26	be	be	AUX	VB	VerbForm=Inf	_	_	_	_
27	induced	induce	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
28	in	in	ADP	IN	_	_	_	_	_
29	precursor	precursor	ADJ	JJ	Degree=Pos	_	_	_	_
30	B	b	ADJ	JJ	Degree=Pos	_	_	_	_
31	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
32	by	by	ADP	IN	_	_	_	_	_
33	stimulation	stimulation	NOUN	NN	Number=Sing	_	_	_	_
34	with	with	ADP	IN	_	_	_	_	_
35	bacterial	bacterial	ADJ	JJ	Degree=Pos	_	_	_	_
36	lipopolysaccharide	lipopolysaccharide	NOUN	NN	Number=Sing	_	_	_	_
37	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
38	LPS	LPS	INTJ	UH	_	_	_	_	SpaceAfter=No
39	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
40	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1185
# text = However, the precise factors that mediate this induction mechanism remain unknown.
1	However	however	ADV	RB	_	_	_	_	SpaceAfter=No
2	,	,	PUNCT	,	_	_	_	_	_
3	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
4	precise	precise	ADJ	JJ	Degree=Pos	_	_	_	_
5	factors	factor	NOUN	NNS	Number=Plur	_	_	_	_
6	that	that	PRON	WDT	PronType=Rel	_	_	_	_
7	mediate	mediate	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
8	this	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
9	induction	induction	NOUN	NN	Number=Sing	_	_	_	_
10	mechanism	mechanism	NOUN	NN	Number=Sing	_	_	_	_
11	remain	remain	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
12	unknown	unknown	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
13	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1186
# text = In the present study, we monitored Oct-2 expression in cells arrested for the activation of NF-kappaB, an LPS-responsive member of the Rel transcription factor family.
1	In	in	ADP	IN	_	_	_	_	_
2	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
3	present	present	ADJ	JJ	Degree=Pos	_	_	_	_
4	study	study	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
5	,	,	PUNCT	,	_	_	_	_	_
6	we	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
7	monitored	monitor	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
8	Oct	Oct	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
9	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
10	2	2	NUM	CD	NumType=Card	_	_	_	_
11	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
12	in	in	ADP	IN	_	_	_	_	_
13	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
14	arrested	arrest	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
15	for	for	ADP	IN	_	_	_	_	_
16	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
17	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
18	of	of	ADP	IN	_	_	_	_	_
19	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
20	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
21	kappaB	kappaB	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
22	,	,	PUNCT	,	_	_	_	_	_
23	an	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
24	LPS	LPS	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
25	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
26	responsive	responsive	ADJ	JJ	Degree=Pos	_	_	_	_
27	member	member	NOUN	NN	Number=Sing	_	_	_	_
28	of	of	ADP	IN	_	_	_	_	_
29	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
30	Rel	Rel	PROPN	NNP	Number=Sing	_	_	_	_
31	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
32	factor	factor	NOUN	NN	Number=Sing	_	_	_	_
33	family	family	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
34	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1187
# text = Despite stimulation with LPS, disruption of the NF-kappaB signaling pathway in precursor B cells led to the loss of inducible Oct-2 DNA binding activity in vitro and the suppression of Oct-2-directed transcription in vivo.
1	Despite	despite	ADP	IN	_	_	_	_	_
2	stimulation	stimulation	NOUN	NN	Number=Sing	_	_	_	_
3	with	with	ADP	IN	_	_	_	_	_
4	LPS	LPS	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
5	,	,	PUNCT	,	_	_	_	_	_
6	disruption	disruption	NOUN	NN	Number=Sing	_	_	_	_
7	of	of	ADP	IN	_	_	_	_	_
8	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
9	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
10	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
11	kappaB	kappaB	PROPN	NNP	Number=Sing	_	_	_	_
12	signaling	signal	VERB	VBG	VerbForm=Ger	_	_	_	_
13	pathway	pathway	NOUN	NN	Number=Sing	_	_	_	_
14	in	in	ADP	IN	_	_	_	_	_
15	precursor	precursor	ADJ	JJ	Degree=Pos	_	_	_	_
16	B	b	PROPN	NNP	Number=Sing	_	_	_	_
17	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
18	led	lead	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
19	to	to	ADP	IN	_	_	_	_	_
20	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
21	loss	loss	NOUN	NN	Number=Sing	_	_	_	_
22	of	of	ADP	IN	_	_	_	_	_
23	inducible	inducible	ADJ	JJ	Degree=Pos	_	_	_	_
24	Oct	Oct	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
25	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
26	2	2	NUM	CD	NumType=Card	_	_	_	_
27	DNA	dna	NOUN	NN	Number=Sing	_	_	_	_
28	binding	binding	VERB	VBG	VerbForm=Ger	_	_	_	_
29	activity	activity	NOUN	NN	Number=Sing	_	_	_	_
30	in	in	ADP	IN	_	_	_	_	_
31	vitro	vitro	NOUN	NN	Number=Sing	_	_	_	_
32	and	and	CCONJ	CC	_	_	_	_	_
33	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
34	suppression	suppression	NOUN	NN	Number=Sing	_	_	_	_
35	of	of	ADP	IN	_	_	_	_	_
36	Oct	Oct	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
37	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
38	2	2	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
39	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
40	directed	direct	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
41	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
42	in	in	ADP	IN	_	_	_	_	_
43	vivo	vivo	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
44	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1188
# text = This biochemical defect correlated with a specific block to Oct-2 gene expression at the level of transcription, whereas the expression of Oct-1 was unaffected.
1	This	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
2	biochemical	biochemical	ADJ	JJ	Degree=Pos	_	_	_	_
3	defect	defect	NOUN	NN	Number=Sing	_	_	_	_
4	correlated	correlate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
5	with	with	ADP	IN	_	_	_	_	_
6	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
7	specific	specific	ADJ	JJ	Degree=Pos	_	_	_	_
8	block	block	NOUN	NN	Number=Sing	_	_	_	_
9	to	to	ADP	IN	_	_	_	_	_
10	Oct	Oct	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
11	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
12	2	2	NUM	CD	NumType=Card	_	_	_	_
13	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
14	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
15	at	at	ADP	IN	_	_	_	_	_
16	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
17	level	level	NOUN	NN	Number=Sing	_	_	_	_
18	of	of	ADP	IN	_	_	_	_	_
19	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
20	,	,	PUNCT	,	_	_	_	_	_
21	whereas	whereas	SCONJ	IN	_	_	_	_	_
22	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
23	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
24	of	of	ADP	IN	_	_	_	_	_
25	Oct	Oct	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
26	-1	-1	NUM	CD	NumType=Card	_	_	_	_
27	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
28	unaffected	unaffected	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
29	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1189
# text = The finding that Oct-2 is under NF-kappaB control highlights an important cross-talk mechanism involving two distinct transcription factor families that regulate B lymphocyte function.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	finding	finding	NOUN	NN	Number=Sing	_	_	_	_
3	that	that	PRON	WDT	PronType=Rel	_	_	_	_
4	Oct	Oct	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
5	-	-	SYM	SYM	_	_	_	_	SpaceAfter=No
6	2	2	NUM	CD	NumType=Card	_	_	_	_
7	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
8	under	under	ADP	IN	_	_	_	_	_
9	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
10	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
11	kappaB	kappaB	PROPN	NNP	Number=Sing	_	_	_	_
12	control	control	NOUN	NN	Number=Sing	_	_	_	_
13	highlights	highlight	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
14	an	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
15	important	important	ADJ	JJ	Degree=Pos	_	_	_	_
16	cross-talk	cross-talk	NOUN	NN	Number=Sing	_	_	_	_
17	mechanism	mechanism	NOUN	NN	Number=Sing	_	_	_	_
18	involving	involve	VERB	VBG	VerbForm=Ger	_	_	_	_
19	two	two	NUM	CD	NumType=Card	_	_	_	_
20	distinct	distinct	ADJ	JJ	Degree=Pos	_	_	_	_
21	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
22	factor	factor	NOUN	NN	Number=Sing	_	_	_	_
23	families	family	NOUN	NNS	Number=Plur	_	_	_	_
24	that	that	PRON	WDT	PronType=Rel	_	_	_	_
25	regulate	regulate	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
26	B	b	ADJ	JJ	Degree=Pos	_	_	_	_
27	lymphocyte	lymphocyte	NOUN	NN	Number=Sing	_	_	_	_
28	function	function	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
29	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 1190
# text = Document 003002412 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	003002412	003002412	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 1191
# text = Interleukin 10 induced c-fos expression in human B cells by activation of divergent protein kinases.
1	Interleukin	Interleukin	PROPN	NNP	Number=Sing	_	_	_	_
2	10	10	NUM	CD	NumType=Card	_	_	_	_
3	induced	induce	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
4	c	c	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
5	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
6	fos	fos	NOUN	NNS	Number=Plur	_	_	_	_
7	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
8	in	in	ADP	IN	_	_	_	_	_
9	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
10	B	b	ADJ	JJ	Degree=Pos	_	_	_	_
11	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
12	by	by	ADP	IN	_	_	_	_	_
13	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
14	of	of	ADP	IN	_	_	_	_	_
15	divergent	divergent	ADJ	JJ	Degree=Pos	_	_	_	_
16	protein	protein	NOUN	NN	Number=Sing	_	_	_	_
17	kinases	kinase	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
18	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 1192
# text = IL-10 is a potent mediator of human B cell growth and plasma cell formation.
1	IL	Il	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
2	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
3	10	10	NUM	CD	NumType=Card	_	_	_	_
4	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
5	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
6	potent	potent	NOUN	NN	Number=Sing	_	_	_	_
7	mediator	mediator	NOUN	NN	Number=Sing	_	_	_	_
8	of	of	ADP	IN	_	_	_	_	_
9	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
10	B	b	NOUN	NN	Number=Sing	_	_	_	_
11	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
12	growth	growth	NOUN	NN	Number=Sing	_	_	_	_
13	and	and	CCONJ	CC	_	_	_	_	_
14	plasma	plasma	NOUN	NN	Number=Sing	_	_	_	_
15	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
16	formation	formation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
17	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1193
# text = However, signal transduction of IL-10 in B cells is poorly understood.
1	However	however	ADV	RB	_	_	_	_	SpaceAfter=No
2	,	,	PUNCT	,	_	_	_	_	_
3	signal	signal	VERB	VB	Mood=Imp|VerbForm=Fin	_	_	_	_
4	transduction	transduction	NOUN	NN	Number=Sing	_	_	_	_
5	of	of	ADP	IN	_	_	_	_	_
6	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
7	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
8	10	10	NUM	CD	NumType=Card	_	_	_	_
9	in	in	ADP	IN	_	_	_	_	_
10	B	b	ADJ	JJ	Degree=Pos	_	_	_	_
11	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
12	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
13	poorly	poorly	ADV	RB	_	_	_	_	_
14	understood	understand	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	SpaceAfter=No
15	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1194
# text = In this study the effect of IL-10 on the expression of the protooncogene c-fos was investigated, because Fos plays a potential role in the regulation of B cell proliferation and differentiation.
1	In	in	ADP	IN	_	_	_	_	_
2	this	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
3	study	study	NOUN	NN	Number=Sing	_	_	_	_
4	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
5	effect	effect	NOUN	NN	Number=Sing	_	_	_	_
6	of	of	ADP	IN	_	_	_	_	_
7	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
8	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
9	10	10	NUM	CD	NumType=Card	_	_	_	_
10	on	on	ADP	IN	_	_	_	_	_
11	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
12	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
13	of	of	ADP	IN	_	_	_	_	_
14	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
15	protooncogene	protooncogene	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
16	c	c	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
17	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
18	fos	fos	NOUN	NNS	Number=Plur	_	_	_	_
19	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
20	investigated	investigate	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	SpaceAfter=No
21	,	,	PUNCT	,	_	_	_	_	_
22	because	because	SCONJ	IN	_	_	_	_	_
23	Fos	Fos	PROPN	NNP	Number=Sing	_	_	_	_
24	plays	play	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
25	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
26	potential	potential	ADJ	JJ	Degree=Pos	_	_	_	_
27	role	role	NOUN	NN	Number=Sing	_	_	_	_
28	in	in	ADP	IN	_	_	_	_	_
29	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
30	regulation	regulation	NOUN	NN	Number=Sing	_	_	_	_
31	of	of	ADP	IN	_	_	_	_	_
32	B	b	ADJ	JJ	Degree=Pos	_	_	_	_
33	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
34	proliferation	proliferation	NOUN	NN	Number=Sing	_	_	_	_
35	and	and	CCONJ	CC	_	_	_	_	_
36	differentiation	differentiation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
37	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1195
# text = B cells were purified from buffy coat preparations of healthy blood donors by positive selection using an anti CD20 monoclonal antibody and a MiniMACS separation unit.
1	B	b	ADJ	JJ	Degree=Pos	_	_	_	_
2	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
3	were	be	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
4	purified	purify	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
5	from	from	ADP	IN	_	_	_	_	_
6	buffy	buffy	NOUN	NN	Number=Sing	_	_	_	_
7	coat	coat	NOUN	NN	Number=Sing	_	_	_	_
8	preparations	preparation	NOUN	NNS	Number=Plur	_	_	_	_
9	of	of	ADP	IN	_	_	_	_	_
10	healthy	healthy	ADJ	JJ	Degree=Pos	_	_	_	_
11	blood	blood	NOUN	NN	Number=Sing	_	_	_	_
12	donors	donor	NOUN	NNS	Number=Plur	_	_	_	_
13	by	by	ADP	IN	_	_	_	_	_
14	positive	positive	ADJ	JJ	Degree=Pos	_	_	_	_
15	selection	selection	NOUN	NN	Number=Sing	_	_	_	_
16	using	use	VERB	VBG	VerbForm=Ger	_	_	_	_
17	an	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
18	anti	anti	X	AFX	_	_	_	_	_
19	CD20	CD20	PROPN	NNP	Number=Sing	_	_	_	_
20	monoclonal	monoclonal	ADJ	JJ	Degree=Pos	_	_	_	_
21	antibody	antibody	NOUN	NN	Number=Sing	_	_	_	_
22	and	and	CCONJ	CC	_	_	_	_	_
23	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
24	MiniMACS	MiniMACS	PROPN	NNP	Number=Sing	_	_	_	_
25	separation	separation	NOUN	NN	Number=Sing	_	_	_	_
26	unit	unit	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
27	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1196
# text = B cells were prestimulated with SAC for 48 hrs.
1	B	b	ADJ	JJ	Degree=Pos	_	_	_	_
2	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
3	were	be	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
4	prestimulated	prestimulate	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
5	with	with	ADP	IN	_	_	_	_	_
6	SAC	Sac	PROPN	NNP	Number=Sing	_	_	_	_
7	for	for	ADP	IN	_	_	_	_	_
8	48	48	NUM	CD	NumType=Card	_	_	_	_
9	hrs	hr	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
10	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1197
# text = Then, cells were incubated with medium or IL-10 (100 ng/ml) for 10 to 120 min.
1	Then	then	ADV	RB	PronType=Dem	_	_	_	SpaceAfter=No
2	,	,	PUNCT	,	_	_	_	_	_
3	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
4	were	be	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
5	incubated	incubate	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
6	with	with	ADP	IN	_	_	_	_	_
7	medium	medium	NOUN	NN	Number=Sing	_	_	_	_
8	or	or	CCONJ	CC	_	_	_	_	_
9	IL-10	IL-10	NUM	CD	NumType=Card	_	_	_	_
10	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
11	100	100	NUM	CD	NumType=Card	_	_	_	_
12	ng/	ng/	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
13	ml	ml	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
14	)	)	PUNCT	-RRB-	_	_	_	_	_
15	for	for	ADP	IN	_	_	_	_	_
16	10	10	NUM	CD	NumType=Card	_	_	_	_
17	to	to	ADP	IN	_	_	_	_	_
18	120	120	NUM	CD	NumType=Card	_	_	_	_
19	min	min	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
20	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1198
# text = RNA was extracted by phenol/chloroform and c-fos expression was analyzed by PCR assisted mRNA assay.
1	RNA	RNa	PROPN	NNP	Number=Sing	_	_	_	_
2	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
3	extracted	extract	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
4	by	by	ADP	IN	_	_	_	_	_
5	phenol	phenol	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
6	/	/	PUNCT	,	_	_	_	_	SpaceAfter=No
7	chloroform	chloroform	NOUN	NN	Number=Sing	_	_	_	_
8	and	and	CCONJ	CC	_	_	_	_	_
9	c	c	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
10	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
11	fos	fos	NOUN	NNS	Number=Plur	_	_	_	_
12	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
13	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
14	analyzed	analyze	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
15	by	by	ADP	IN	_	_	_	_	_
16	PCR	PCR	PROPN	NNP	Number=Sing	_	_	_	_
17	assisted	assist	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
18	mRNA	mRNA	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
19	assay	assay	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
20	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1199
# text = A significant 2-4 fold increase of c-fos expression was observed within 30 min of stimulation with IL-10 (p < 0.01).
1	A	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
2	significant	significant	ADJ	JJ	Degree=Pos	_	_	_	_
3	2	2	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
4	-	-	SYM	SYM	_	_	_	_	SpaceAfter=No
5	4	4	NUM	CD	NumType=Card	_	_	_	_
6	fold	fold	NOUN	NN	Number=Sing	_	_	_	_
7	increase	increase	NOUN	NN	Number=Sing	_	_	_	_
8	of	of	ADP	IN	_	_	_	_	_
9	c	c	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
10	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
11	fos	fo	NOUN	NNS	Number=Plur	_	_	_	_
12	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
13	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
14	observed	observe	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
15	within	within	ADP	IN	_	_	_	_	_
16	30	30	NUM	CD	NumType=Card	_	_	_	_
17	min	min	NOUN	NNS	Number=Plur	_	_	_	_
18	of	of	ADP	IN	_	_	_	_	_
19	stimulation	stimulation	NOUN	NN	Number=Sing	_	_	_	_
20	with	with	ADP	IN	_	_	_	_	_
21	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
22	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
23	10	10	NUM	CD	NumType=Card	_	_	_	_
24	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
25	p	p	NOUN	NN	Number=Sing	_	_	_	_
26	<	<	PUNCT	-LRB-	_	_	_	_	_
27	0.01	0.01	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
28	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
29	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1200
# text = After 2 hrs c-fos expression declined to basal levels.
1	After	after	ADP	IN	_	_	_	_	_
2	2	2	NUM	CD	NumType=Card	_	_	_	_
3	hrs	hr	NOUN	NNS	Number=Plur	_	_	_	_
4	c	c	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
5	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
6	fos	fo	NOUN	NNS	Number=Plur	_	_	_	_
7	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
8	declined	decline	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
9	to	to	ADP	IN	_	_	_	_	_
10	basal	basal	ADJ	JJ	Degree=Pos	_	_	_	_
11	levels	level	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
12	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1201
# text = The effect of IL-10 was dose-dependent with a maximum stimulation using 100 ng/ml of IL-10.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	effect	effect	NOUN	NN	Number=Sing	_	_	_	_
3	of	of	ADP	IN	_	_	_	_	_
4	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
5	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
6	10	10	NUM	CD	NumType=Card	_	_	_	_
7	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
8	dose	dose	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
9	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
10	dependent	dependent	ADJ	JJ	Degree=Pos	_	_	_	_
11	with	with	ADP	IN	_	_	_	_	_
12	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
13	maximum	maximum	NOUN	NN	Number=Sing	_	_	_	_
14	stimulation	stimulation	NOUN	NN	Number=Sing	_	_	_	_
15	using	use	VERB	VBG	VerbForm=Ger	_	_	_	_
16	100	100	NUM	CD	NumType=Card	_	_	_	_
17	ng/ml	ng/ml	NOUN	NN	Number=Sing	_	_	_	_
18	of	of	ADP	IN	_	_	_	_	_
19	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
20	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
21	10	10	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
22	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1202
# text = The IL-10 effect on c-fos expression was not blocked by polymyxin B. Using the tyrosine kinase inhibitor genistein (10 microM) a complete inhibition of IL-10 induced c-fos expression was observed.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	IL	Il	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
3	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
4	10	10	NUM	CD	NumType=Card	_	_	_	_
5	effect	effect	NOUN	NN	Number=Sing	_	_	_	_
6	on	on	ADP	IN	_	_	_	_	_
7	c	c	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
8	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
9	fos	fo	NOUN	NNS	Number=Plur	_	_	_	_
10	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
11	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
12	not	not	PART	RB	_	_	_	_	_
13	blocked	block	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
14	by	by	ADP	IN	_	_	_	_	_
15	polymyxin	polymyxin	NOUN	NN	Number=Sing	_	_	_	_
16	B	b	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
17	.	.	PUNCT	.	_	_	_	_	_
18	Using	use	VERB	VBG	VerbForm=Ger	_	_	_	_
19	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
20	tyrosine	tyrosine	NOUN	NN	Number=Sing	_	_	_	_
21	kinase	kinase	NOUN	NN	Number=Sing	_	_	_	_
22	inhibitor	inhibitor	NOUN	NN	Number=Sing	_	_	_	_
23	genistein	genistein	NOUN	NN	Number=Sing	_	_	_	_
24	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
25	10	10	NUM	CD	NumType=Card	_	_	_	_
26	microM	microm	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
27	)	)	PUNCT	-RRB-	_	_	_	_	_
28	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
29	complete	complete	ADJ	JJ	Degree=Pos	_	_	_	_
30	inhibition	inhibition	NOUN	NN	Number=Sing	_	_	_	_
31	of	of	ADP	IN	_	_	_	_	_
32	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
33	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
34	10	10	NUM	CD	NumType=Card	_	_	_	_
35	induced	induce	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
36	c	c	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
37	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
38	fos	fo	NOUN	NNS	Number=Plur	_	_	_	_
39	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
40	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
41	observed	observe	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	SpaceAfter=No
42	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1203
# text = In addition, H-7 (10 microM), a specific inhibitor of serine/threonine kinases, significantly blocked IL-10 mediated c-fos expression (p < 0.05).
1	In	in	ADP	IN	_	_	_	_	_
2	addition	addition	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
3	,	,	PUNCT	,	_	_	_	_	_
4	H	H	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
5	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
6	7	7	NUM	CD	NumType=Card	_	_	_	_
7	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
8	10	10	NUM	CD	NumType=Card	_	_	_	_
9	microM	microm	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
10	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
11	,	,	PUNCT	,	_	_	_	_	_
12	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
13	specific	specific	ADJ	JJ	Degree=Pos	_	_	_	_
14	inhibitor	inhibitor	NOUN	NN	Number=Sing	_	_	_	_
15	of	of	ADP	IN	_	_	_	_	_
16	serine	serine	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
17	/	/	PUNCT	,	_	_	_	_	SpaceAfter=No
18	threonine	threonine	NUM	CD	NumType=Card	_	_	_	_
19	kinases	kinase	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
20	,	,	PUNCT	,	_	_	_	_	_
21	significantly	significantly	ADV	RB	_	_	_	_	_
22	blocked	block	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
23	IL	il	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
24	-	-	SYM	SYM	_	_	_	_	SpaceAfter=No
25	10	10	NUM	CD	NumType=Card	_	_	_	_
26	mediated	mediate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
27	c	c	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
28	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
29	fos	fo	NOUN	NN	Number=Sing	_	_	_	_
30	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
31	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
32	p	p	NOUN	NN	Number=Sing	_	_	_	_
33	<	<	PUNCT	-LRB-	_	_	_	_	_
34	0.05	0.05	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
35	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
36	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1204
# text = In conclusion, these data show that IL-10 induces c-fos expression in human B-cells by activation of tyrosine and serine/threonine kinases.
1	In	in	ADP	IN	_	_	_	_	_
2	conclusion	conclusion	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
3	,	,	PUNCT	,	_	_	_	_	_
4	these	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
5	data	data	NOUN	NN	Number=Sing	_	_	_	_
6	show	show	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
7	that	that	SCONJ	IN	_	_	_	_	_
8	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
9	-	-	SYM	SYM	_	_	_	_	SpaceAfter=No
10	10	10	NUM	CD	NumType=Card	_	_	_	_
11	induces	induce	NOUN	NNS	Number=Plur	_	_	_	_
12	c-	c-	SYM	SYM	_	_	_	_	SpaceAfter=No
13	fos	fo	NOUN	NNS	Number=Plur	_	_	_	_
14	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
15	in	in	ADP	IN	_	_	_	_	_
16	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
17	B-	b-	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
18	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
19	by	by	ADP	IN	_	_	_	_	_
20	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
21	of	of	ADP	IN	_	_	_	_	_
22	tyrosine	tyrosine	NOUN	NN	Number=Sing	_	_	_	_
23	and	and	CCONJ	CC	_	_	_	_	_
24	serine	serine	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
25	/	/	PUNCT	,	_	_	_	_	SpaceAfter=No
26	threonine	threonine	NUM	CD	NumType=Card	_	_	_	_
27	kinases	kinase	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
28	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1205
# text = Since this is the first report on IL-10 induced signal transduction, these data may help to identify the intracellular mechanisms by which IL-10 stimulates human B-cells.
1	Since	since	SCONJ	IN	_	_	_	_	_
2	this	this	PRON	DT	Number=Sing|PronType=Dem	_	_	_	_
3	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
4	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
5	first	first	ADJ	JJ	Degree=Pos|NumType=Ord	_	_	_	_
6	report	report	NOUN	NN	Number=Sing	_	_	_	_
7	on	on	ADP	IN	_	_	_	_	_
8	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
9	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
10	10	10	NUM	CD	NumType=Card	_	_	_	_
11	induced	induce	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
12	signal	signal	NOUN	NN	Number=Sing	_	_	_	_
13	transduction	transduction	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
14	,	,	PUNCT	,	_	_	_	_	_
15	these	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
16	data	data	NOUN	NN	Number=Sing	_	_	_	_
17	may	may	AUX	MD	VerbForm=Fin	_	_	_	_
18	help	help	VERB	VB	VerbForm=Inf	_	_	_	_
19	to	to	PART	TO	_	_	_	_	_
20	identify	identify	VERB	VB	VerbForm=Inf	_	_	_	_
21	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
22	intracellular	intracellular	ADJ	JJ	Degree=Pos	_	_	_	_
23	mechanisms	mechanism	NOUN	NNS	Number=Plur	_	_	_	_
24	by	by	ADP	IN	_	_	_	_	_
25	which	which	PRON	WDT	PronType=Rel	_	_	_	_
26	IL	Il	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
27	-	-	SYM	SYM	_	_	_	_	SpaceAfter=No
28	10	10	NUM	CD	NumType=Card	_	_	_	_
29	stimulates	stimulate	NOUN	NNS	Number=Plur	_	_	_	_
30	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
31	B-	b-	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
32	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
33	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 1206
# text = Document 003002422 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	003002422	003002422	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 1207
# text = GM-CSF and IL-2 share common control mechanisms in response to costimulatory signals in T cells.
1	GM	GM	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
2	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
3	CSF	CSF	PROPN	NNP	Number=Sing	_	_	_	_
4	and	and	CCONJ	CC	_	_	_	_	_
5	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
6	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
7	2	2	NUM	CD	NumType=Card	_	_	_	_
8	share	share	NOUN	NN	Number=Sing	_	_	_	_
9	common	common	ADJ	JJ	Degree=Pos	_	_	_	_
10	control	control	NOUN	NN	Number=Sing	_	_	_	_
11	mechanisms	mechanism	NOUN	NNS	Number=Plur	_	_	_	_
12	in	in	ADP	IN	_	_	_	_	_
13	response	response	NOUN	NN	Number=Sing	_	_	_	_
14	to	to	PART	TO	_	_	_	_	_
15	costimulatory	costimulatory	VERB	VB	VerbForm=Inf	_	_	_	_
16	signals	signal	NOUN	NNS	Number=Plur	_	_	_	_
17	in	in	ADP	IN	_	_	_	_	_
18	T	t	PROPN	NNP	Number=Sing	_	_	_	_
19	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
20	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 1208
# text = Antigen complexed with major histocompatibility complex class I or II molecules on the surface of antigen presenting cells interacts with the T cell receptor (TCR) on the surface of T cells and initiates an activation cascade.
1	Antigen	Antigen	PROPN	NNP	Number=Sing	_	_	_	_
2	complexed	complex	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
3	with	with	ADP	IN	_	_	_	_	_
4	major	major	ADJ	JJ	Degree=Pos	_	_	_	_
5	histocompatibility	histocompatibility	NOUN	NN	Number=Sing	_	_	_	_
6	complex	complex	NOUN	NN	Number=Sing	_	_	_	_
7	class	class	NOUN	NN	Number=Sing	_	_	_	_
8	I	I	PRON	PRP	Case=Nom|Number=Sing|Person=1|PronType=Prs	_	_	_	_
9	or	or	CCONJ	CC	_	_	_	_	_
10	II	ii	NUM	CD	NumType=Card	_	_	_	_
11	molecules	molecule	NOUN	NNS	Number=Plur	_	_	_	_
12	on	on	ADP	IN	_	_	_	_	_
13	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
14	surface	surface	NOUN	NN	Number=Sing	_	_	_	_
15	of	of	ADP	IN	_	_	_	_	_
16	antigen	antigen	NOUN	NNS	Number=Plur	_	_	_	_
17	presenting	presenting	VERB	VBG	VerbForm=Ger	_	_	_	_
18	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
19	interacts	interact	NOUN	NNS	Number=Plur	_	_	_	_
20	with	with	ADP	IN	_	_	_	_	_
21	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
22	T	T	PROPN	NNP	Number=Sing	_	_	_	_
23	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
24	receptor	receptor	NOUN	NN	Number=Sing	_	_	_	_
25	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
26	TCR	TCR	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
27	)	)	PUNCT	-RRB-	_	_	_	_	_
28	on	on	ADP	IN	_	_	_	_	_
29	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
30	surface	surface	NOUN	NN	Number=Sing	_	_	_	_
31	of	of	ADP	IN	_	_	_	_	_
32	T	t	PROPN	NNP	Number=Sing	_	_	_	_
33	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
34	and	and	CCONJ	CC	_	_	_	_	_
35	initiates	initiate	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
36	an	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
37	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
38	cascade	cascade	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
39	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1209
# text = So called costimulatory signals, mediated by other cell surface interactions or soluble cytokines produced by antigen presenting cells, are also required for complete T cell activation.
1	So	so	ADV	RB	_	_	_	_	_
2	called	call	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
3	costimulatory	costimulatory	ADJ	JJ	Degree=Pos	_	_	_	_
4	signals	signal	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
5	,	,	PUNCT	,	_	_	_	_	_
6	mediated	mediate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
7	by	by	ADP	IN	_	_	_	_	_
8	other	other	ADJ	JJ	Degree=Pos	_	_	_	_
9	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
10	surface	surface	NOUN	NN	Number=Sing	_	_	_	_
11	interactions	interaction	NOUN	NNS	Number=Plur	_	_	_	_
12	or	or	CCONJ	CC	_	_	_	_	_
13	soluble	soluble	ADJ	JJ	Degree=Pos	_	_	_	_
14	cytokines	cytokine	NOUN	NNS	Number=Plur	_	_	_	_
15	produced	produce	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
16	by	by	ADP	IN	_	_	_	_	_
17	antigen	antigen	ADJ	JJ	Degree=Pos	_	_	_	_
18	presenting	presenting	ADJ	JJ	Degree=Pos	_	_	_	_
19	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
20	,	,	PUNCT	,	_	_	_	_	_
21	are	be	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
22	also	also	ADV	RB	_	_	_	_	_
23	required	require	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
24	for	for	ADP	IN	_	_	_	_	_
25	complete	complete	ADJ	JJ	Degree=Pos	_	_	_	_
26	T	T	PROPN	NNP	Number=Sing	_	_	_	_
27	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
28	activation	activation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
29	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1210
# text = High levels of cytokine gene expression in T cells also required both TCR and costimulatory signals.
1	High	high	ADJ	JJ	Degree=Pos	_	_	_	_
2	levels	level	NOUN	NNS	Number=Plur	_	_	_	_
3	of	of	ADP	IN	_	_	_	_	_
4	cytokine	cytokine	NOUN	NN	Number=Sing	_	_	_	_
5	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
6	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
7	in	in	ADP	IN	_	_	_	_	_
8	T	t	PROPN	NNP	Number=Sing	_	_	_	_
9	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
10	also	also	ADV	RB	_	_	_	_	_
11	required	require	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
12	both	both	DET	DT	_	_	_	_	_
13	TCR	TCR	NOUN	NN	Number=Sing	_	_	_	_
14	and	and	CCONJ	CC	_	_	_	_	_
15	costimulatory	costimulatory	ADJ	JJ	Degree=Pos	_	_	_	_
16	signals	signal	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
17	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1211
# text = The granulocyte-macrophage colony-stimulating factor requires sequences in the promoter as well as a powerful enhancer located 3kb upstream to respond to TCR-like signals.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	granulocyte	granulocyte	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
3	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
4	macrophage	macrophage	NOUN	NN	Number=Sing	_	_	_	_
5	colony	colony	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
6	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
7	stimulating	stimulating	NOUN	NN	Number=Sing	_	_	_	_
8	factor	factor	NOUN	NN	Number=Sing	_	_	_	_
9	requires	require	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
10	sequences	sequence	NOUN	NNS	Number=Plur	_	_	_	_
11	in	in	ADP	IN	_	_	_	_	_
12	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
13	promoter	promoter	NOUN	NN	Number=Sing	_	_	_	_
14	as	as	ADV	RB	_	_	_	_	_
15	well	well	ADV	RB	Degree=Pos	_	_	_	_
16	as	as	ADP	IN	_	_	_	_	_
17	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
18	powerful	powerful	ADJ	JJ	Degree=Pos	_	_	_	_
19	enhancer	enhancer	NOUN	NN	Number=Sing	_	_	_	_
20	located	locate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
21	3	3	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
22	kb	kb	NOUN	NN	Number=Sing	_	_	_	_
23	upstream	upstream	NOUN	NN	Number=Sing	_	_	_	_
24	to	to	PART	TO	_	_	_	_	_
25	respond	respond	VERB	VB	VerbForm=Inf	_	_	_	_
26	to	to	ADP	IN	_	_	_	_	_
27	TCR	TCR	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
28	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
29	like	like	ADP	IN	_	_	_	_	_
30	signals	signal	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
31	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1212
# text = These promoter and enhancer regions are mainly activated by the transcription factor nuclear factor of activated T cells (NFAT).
1	These	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
2	promoter	promoter	NOUN	NN	Number=Sing	_	_	_	_
3	and	and	CCONJ	CC	_	_	_	_	_
4	enhancer	enhancer	NOUN	NN	Number=Sing	_	_	_	_
5	regions	region	NOUN	NNS	Number=Plur	_	_	_	_
6	are	be	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
7	mainly	mainly	ADV	RB	_	_	_	_	_
8	activated	activate	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
9	by	by	ADP	IN	_	_	_	_	_
10	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
11	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
12	factor	factor	NOUN	NN	Number=Sing	_	_	_	_
13	nuclear	nuclear	ADJ	JJ	Degree=Pos	_	_	_	_
14	factor	factor	NOUN	NN	Number=Sing	_	_	_	_
15	of	of	ADP	IN	_	_	_	_	_
16	activated	activate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
17	T	t	PROPN	NNP	Number=Sing	_	_	_	_
18	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
19	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
20	NFAT	NFAT	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
21	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
22	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1213
# text = The activation of NFAT by TCR signals has been well described for interleukin-2 (IL-2) and IL-4 gene transcription in T cells.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
3	of	of	ADP	IN	_	_	_	_	_
4	NFAT	NFAT	PROPN	NNP	Number=Sing	_	_	_	_
5	by	by	ADP	IN	_	_	_	_	_
6	TCR	TCR	PROPN	NNP	Number=Sing	_	_	_	_
7	signals	signal	NOUN	NNS	Number=Plur	_	_	_	_
8	has	have	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
9	been	be	AUX	VBN	Tense=Past|VerbForm=Part	_	_	_	_
10	well	well	ADV	RB	Degree=Pos	_	_	_	_
11	described	describe	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
12	for	for	ADP	IN	_	_	_	_	_
13	interleukin	interleukin	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
14	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
15	2	2	NUM	CD	NumType=Card	_	_	_	_
16	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
17	IL	Il	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
18	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
19	2	2	X	LS	_	_	_	_	SpaceAfter=No
20	)	)	PUNCT	-RRB-	_	_	_	_	_
21	and	and	CCONJ	CC	_	_	_	_	_
22	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
23	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
24	4	4	NUM	CD	NumType=Card	_	_	_	_
25	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
26	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
27	in	in	ADP	IN	_	_	_	_	_
28	T	t	PROPN	NNP	Number=Sing	_	_	_	_
29	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
30	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1214
# text = Costimulatory signals, such as activation of the CD28 cell surface molecule on T cells, lead to activation through a distinct region of the granulocyte-macrophage colony-stimulating factor (GM-CSF) promoter.
1	Costimulatory	Costimulatory	ADJ	JJ	Degree=Pos	_	_	_	_
2	signals	signal	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
3	,	,	PUNCT	,	_	_	_	_	_
4	such	such	ADJ	JJ	Degree=Pos	_	_	_	_
5	as	as	ADP	IN	_	_	_	_	_
6	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
7	of	of	ADP	IN	_	_	_	_	_
8	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
9	CD28	CD28	PROPN	NNP	Number=Sing	_	_	_	_
10	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
11	surface	surface	NOUN	NN	Number=Sing	_	_	_	_
12	molecule	molecule	NOUN	NN	Number=Sing	_	_	_	_
13	on	on	ADP	IN	_	_	_	_	_
14	T	t	PROPN	NNP	Number=Sing	_	_	_	_
15	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
16	,	,	PUNCT	,	_	_	_	_	_
17	lead	lead	VERB	VB	Mood=Imp|VerbForm=Fin	_	_	_	_
18	to	to	ADP	IN	_	_	_	_	_
19	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
20	through	through	ADP	IN	_	_	_	_	_
21	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
22	distinct	distinct	ADJ	JJ	Degree=Pos	_	_	_	_
23	region	region	NOUN	NN	Number=Sing	_	_	_	_
24	of	of	ADP	IN	_	_	_	_	_
25	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
26	granulocyte	granulocyte	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
27	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
28	macrophage	macrophage	NOUN	NN	Number=Sing	_	_	_	_
29	colony	colony	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
30	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
31	stimulating	stimulating	VERB	VBG	VerbForm=Ger	_	_	_	_
32	factor	factor	NOUN	NN	Number=Sing	_	_	_	_
33	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
34	GM	GM	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
35	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
36	CSF	CSF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
37	)	)	PUNCT	-RRB-	_	_	_	_	_
38	promoter	promoter	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
39	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1215
# text = This region is termed the CK-1 or CD28RE and appears to bind specific members of the NF-kappa B family of transcription factors.
1	This	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
2	region	region	NOUN	NN	Number=Sing	_	_	_	_
3	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
4	termed	term	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
5	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
6	CK	ck	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
7	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
8	1	1	NUM	CD	NumType=Card	_	_	_	_
9	or	or	CCONJ	CC	_	_	_	_	_
10	CD28RE	Cd28re	NOUN	NN	Number=Sing	_	_	_	_
11	and	and	CCONJ	CC	_	_	_	_	_
12	appears	appear	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
13	to	to	PART	TO	_	_	_	_	_
14	bind	bind	VERB	VB	VerbForm=Inf	_	_	_	_
15	specific	specific	ADJ	JJ	Degree=Pos	_	_	_	_
16	members	member	NOUN	NNS	Number=Plur	_	_	_	_
17	of	of	ADP	IN	_	_	_	_	_
18	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
19	NF	Nf	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
20	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
21	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_
22	B	b	NOUN	NN	Number=Sing	_	_	_	_
23	family	family	NOUN	NN	Number=Sing	_	_	_	_
24	of	of	ADP	IN	_	_	_	_	_
25	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
26	factors	factor	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
27	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1216
# text = Human T leukemia virus type 1 (HTLV-1) infects T cells and can lead to increase GM-CSF expression.
1	Human	human	PROPN	NNP	Number=Sing	_	_	_	_
2	T	T	PROPN	NNP	Number=Sing	_	_	_	_
3	leukemia	leukemia	NOUN	NN	Number=Sing	_	_	_	_
4	virus	virus	NOUN	NN	Number=Sing	_	_	_	_
5	type	type	NOUN	NN	Number=Sing	_	_	_	_
6	1	1	NUM	CD	NumType=Card	_	_	_	_
7	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
8	HTLV	Htlv	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
9	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
10	1	1	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
11	)	)	PUNCT	-RRB-	_	_	_	_	_
12	infects	infect	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
13	T	t	PROPN	NNP	Number=Sing	_	_	_	_
14	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
15	and	and	CCONJ	CC	_	_	_	_	_
16	can	can	AUX	MD	VerbForm=Fin	_	_	_	_
17	lead	lead	VERB	VB	VerbForm=Inf	_	_	_	_
18	to	to	PART	TO	_	_	_	_	_
19	increase	increase	VERB	VB	VerbForm=Inf	_	_	_	_
20	GM	GM	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
21	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
22	CSF	CSF	PROPN	NNP	Number=Sing	_	_	_	_
23	expression	expression	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
24	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1217
# text = We have found that the HTLV-1 transactivator protein, tax, acts as a costimulatory signal for GM-CSF and IL-2 gene transcription, in that it can cooperate with TCR signals to mediate high level gene expression.
1	We	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
2	have	have	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
3	found	find	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
4	that	that	SCONJ	IN	_	_	_	_	_
5	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
6	HTLV	HTLV	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
7	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
8	1	1	NUM	CD	NumType=Card	_	_	_	_
9	transactivator	transactivator	NOUN	NN	Number=Sing	_	_	_	_
10	protein	protein	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
11	,	,	PUNCT	,	_	_	_	_	_
12	tax	tax	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
13	,	,	PUNCT	,	_	_	_	_	_
14	acts	act	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
15	as	as	ADP	IN	_	_	_	_	_
16	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
17	costimulatory	costimulatory	NOUN	NN	Number=Sing	_	_	_	_
18	signal	signal	NOUN	NN	Number=Sing	_	_	_	_
19	for	for	ADP	IN	_	_	_	_	_
20	GM	GM	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
21	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
22	CSF	CSF	PROPN	NNP	Number=Sing	_	_	_	_
23	and	and	CCONJ	CC	_	_	_	_	_
24	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
25	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
26	2	2	NUM	CD	NumType=Card	_	_	_	_
27	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
28	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
29	,	,	PUNCT	,	_	_	_	_	_
30	in	in	SCONJ	IN	_	_	_	_	_
31	that	that	SCONJ	IN	_	_	_	_	_
32	it	it	PRON	PRP	Case=Nom|Gender=Neut|Number=Sing|Person=3|PronType=Prs	_	_	_	_
33	can	can	AUX	MD	VerbForm=Fin	_	_	_	_
34	cooperate	cooperate	VERB	VB	VerbForm=Inf	_	_	_	_
35	with	with	ADP	IN	_	_	_	_	_
36	TCR	Tcr	NOUN	NN	Number=Sing	_	_	_	_
37	signals	signal	NOUN	NNS	Number=Plur	_	_	_	_
38	to	to	PART	TO	_	_	_	_	_
39	mediate	mediate	VERB	VB	VerbForm=Inf	_	_	_	_
40	high	high	ADJ	JJ	Degree=Pos	_	_	_	_
41	level	level	NOUN	NN	Number=Sing	_	_	_	_
42	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
43	expression	expression	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
44	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1218
# text = Tax activates the GM-CSF promoter through the CK-1/CD28RE region and also activates nuclear factor-kappa B binding to this region.
1	Tax	tax	NOUN	NN	Number=Sing	_	_	_	_
2	activates	activate	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
3	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
4	GM	GM	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
5	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
6	CSF	CSF	PROPN	NNP	Number=Sing	_	_	_	_
7	promoter	promoter	VERB	VB	VerbForm=Inf	_	_	_	_
8	through	through	ADP	IN	_	_	_	_	_
9	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
10	CK	ck	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
11	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
12	1/CD28RE	1/CD28RE	NOUN	NN	Number=Sing	_	_	_	_
13	region	region	NOUN	NN	Number=Sing	_	_	_	_
14	and	and	CCONJ	CC	_	_	_	_	_
15	also	also	ADV	RB	_	_	_	_	_
16	activates	activate	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
17	nuclear	nuclear	ADJ	JJ	Degree=Pos	_	_	_	_
18	factor	factor	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
19	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
20	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_
21	B	b	NOUN	NN	Number=Sing	_	_	_	_
22	binding	bind	VERB	VBG	VerbForm=Ger	_	_	_	_
23	to	to	ADP	IN	_	_	_	_	_
24	this	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
25	region	region	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
26	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1219
# text = However, other transcription factors or coactivators of NF-kappa B are required for tax activation but these remain to be identified.
1	However	however	ADV	RB	_	_	_	_	SpaceAfter=No
2	,	,	PUNCT	,	_	_	_	_	_
3	other	other	ADJ	JJ	Degree=Pos	_	_	_	_
4	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
5	factors	factor	NOUN	NNS	Number=Plur	_	_	_	_
6	or	or	CCONJ	CC	_	_	_	_	_
7	coactivators	coactivator	NOUN	NNS	Number=Plur	_	_	_	_
8	of	of	ADP	IN	_	_	_	_	_
9	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
10	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
11	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_
12	B	b	NOUN	NN	Number=Sing	_	_	_	_
13	are	be	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
14	required	require	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
15	for	for	ADP	IN	_	_	_	_	_
16	tax	tax	NOUN	NN	Number=Sing	_	_	_	_
17	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
18	but	but	CCONJ	CC	_	_	_	_	_
19	these	these	PRON	DT	Number=Plur|PronType=Dem	_	_	_	_
20	remain	remain	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
21	to	to	PART	TO	_	_	_	_	_
22	be	be	AUX	VB	VerbForm=Inf	_	_	_	_
23	identified	identify	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	SpaceAfter=No
24	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1220
# text = The CK-1/CD28RE of GM-CSF shows a high degree of similarity to the IL-2 CD28RE and the IL-3 gene also contains a related region.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	CK	ck	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
3	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
4	1/CD28RE	1/CD28RE	NOUN	NN	Number=Sing	_	_	_	_
5	of	of	ADP	IN	_	_	_	_	_
6	GM	GM	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
7	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
8	CSF	CSF	PROPN	NNP	Number=Sing	_	_	_	_
9	shows	show	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
10	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
11	high	high	ADJ	JJ	Degree=Pos	_	_	_	_
12	degree	degree	NOUN	NN	Number=Sing	_	_	_	_
13	of	of	ADP	IN	_	_	_	_	_
14	similarity	similarity	NOUN	NN	Number=Sing	_	_	_	_
15	to	to	ADP	IN	_	_	_	_	_
16	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
17	IL	Il	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
18	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
19	2	2	NUM	CD	NumType=Card	_	_	_	_
20	CD28RE	Cd28re	NOUN	NN	Number=Sing	_	_	_	_
21	and	and	CCONJ	CC	_	_	_	_	_
22	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
23	IL	Il	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
24	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
25	3	3	NUM	CD	NumType=Card	_	_	_	_
26	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
27	also	also	ADV	RB	_	_	_	_	_
28	contains	contain	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
29	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
30	related	related	ADJ	JJ	Degree=Pos	_	_	_	_
31	region	region	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
32	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1221
# text = This observation, together with the fact that both GM-CSF and IL-2 respond to TCR signals via NFAT, implies a high degree of conservation in the regulation of cytokine gene expression in T cells.
1	This	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
2	observation	observation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
3	,	,	PUNCT	,	_	_	_	_	_
4	together	together	ADV	RB	_	_	_	_	_
5	with	with	ADP	IN	_	_	_	_	_
6	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
7	fact	fact	NOUN	NN	Number=Sing	_	_	_	_
8	that	that	SCONJ	IN	_	_	_	_	_
9	both	both	CCONJ	CC	_	_	_	_	_
10	GM	GM	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
11	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
12	CSF	CSF	PROPN	NNP	Number=Sing	_	_	_	_
13	and	and	CCONJ	CC	_	_	_	_	_
14	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
15	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
16	2	2	NUM	CD	NumType=Card	_	_	_	_
17	respond	respond	NOUN	NN	Number=Sing	_	_	_	_
18	to	to	PART	TO	_	_	_	_	_
19	TCR	TCR	VERB	VB	VerbForm=Inf	_	_	_	_
20	signals	signal	NOUN	NNS	Number=Plur	_	_	_	_
21	via	via	ADP	IN	_	_	_	_	_
22	NFAT	NFAT	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
23	,	,	PUNCT	,	_	_	_	_	_
24	implies	imply	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
25	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
26	high	high	ADJ	JJ	Degree=Pos	_	_	_	_
27	degree	degree	NOUN	NN	Number=Sing	_	_	_	_
28	of	of	ADP	IN	_	_	_	_	_
29	conservation	conservation	NOUN	NN	Number=Sing	_	_	_	_
30	in	in	ADP	IN	_	_	_	_	_
31	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
32	regulation	regulation	NOUN	NN	Number=Sing	_	_	_	_
33	of	of	ADP	IN	_	_	_	_	_
34	cytokine	cytokine	NOUN	NN	Number=Sing	_	_	_	_
35	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
36	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
37	in	in	ADP	IN	_	_	_	_	_
38	T	t	PROPN	NNP	Number=Sing	_	_	_	_
39	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
40	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 1222
# text = Document 003002426 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	003002426	003002426	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 1223
# text = IL-7 reconstitutes multiple aspects of v-Abl-mediated signaling.
1	IL	Il	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
2	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
3	7	7	NUM	CD	NumType=Card	_	_	_	_
4	reconstitutes	reconstitute	NOUN	NNS	Number=Plur	_	_	_	_
5	multiple	multiple	ADJ	JJ	Degree=Pos	_	_	_	_
6	aspects	aspect	NOUN	NNS	Number=Plur	_	_	_	_
7	of	of	ADP	IN	_	_	_	_	_
8	v	v	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
9	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
10	Abl	Abl	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
11	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
12	mediated	mediate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
13	signaling	signaling	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
14	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 1224
# text = The mechanism by which early lymphoid cells are selectively transformed by v-Abl is currently unknown.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	mechanism	mechanism	NOUN	NN	Number=Sing	_	_	_	_
3	by	by	ADP	IN	_	_	_	_	_
4	which	which	PRON	WDT	PronType=Rel	_	_	_	_
5	early	early	ADJ	JJ	Degree=Pos	_	_	_	_
6	lymphoid	lymphoid	ADJ	JJ	Degree=Pos	_	_	_	_
7	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
8	are	be	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
9	selectively	selectively	ADV	RB	_	_	_	_	_
10	transformed	transform	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
11	by	by	ADP	IN	_	_	_	_	_
12	v	v	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
13	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
14	Abl	Abl	PROPN	NNP	Number=Sing	_	_	_	_
15	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
16	currently	currently	ADV	RB	_	_	_	_	_
17	unknown	unknown	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
18	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1225
# text = Previous studies have shown constitutive activation of IL-4 and IL-7 signaling pathways, as measured by activation of Janus protein kinase (JAK)1, JAK3, STAT5, and STAT6, in pre-B cells transformed by v-Abl.
1	Previous	previous	ADJ	JJ	Degree=Pos	_	_	_	_
2	studies	study	NOUN	NNS	Number=Plur	_	_	_	_
3	have	have	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
4	shown	show	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
5	constitutive	constitutive	ADJ	JJ	Degree=Pos	_	_	_	_
6	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
7	of	of	ADP	IN	_	_	_	_	_
8	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
9	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
10	4	4	NUM	CD	NumType=Card	_	_	_	_
11	and	and	CCONJ	CC	_	_	_	_	_
12	IL	Il	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
13	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
14	7	7	NUM	CD	NumType=Card	_	_	_	_
15	signaling	signaling	NOUN	NN	Number=Sing	_	_	_	_
16	pathways	pathway	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
17	,	,	PUNCT	,	_	_	_	_	_
18	as	as	SCONJ	IN	_	_	_	_	_
19	measured	measure	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
20	by	by	ADP	IN	_	_	_	_	_
21	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
22	of	of	ADP	IN	_	_	_	_	_
23	Janus	Janus	PROPN	NNP	Number=Sing	_	_	_	_
24	protein	protein	NOUN	NN	Number=Sing	_	_	_	_
25	kinase	kinase	NOUN	NN	Number=Sing	_	_	_	_
26	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
27	JAK	JAK	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
28	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
29	1	1	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
30	,	,	PUNCT	,	_	_	_	_	_
31	JAK3	JAK3	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
32	,	,	PUNCT	,	_	_	_	_	_
33	STAT5	STAT5	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
34	,	,	PUNCT	,	_	_	_	_	_
35	and	and	CCONJ	CC	_	_	_	_	_
36	STAT6	Stat6	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
37	,	,	PUNCT	,	_	_	_	_	_
38	in	in	ADP	IN	_	_	_	_	_
39	pre	pre	X	AFX	_	_	_	_	SpaceAfter=No
40	-B	-b	ADJ	JJ	Degree=Pos	_	_	_	_
41	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
42	transformed	transform	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
43	by	by	ADP	IN	_	_	_	_	_
44	v	v	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
45	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
46	Abl	Abl	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
47	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1226
# text = To determine whether activation of these cytokine signaling pathways by v-Abl is important in the cellular events induced by the Abelson murine leukemia virus, the effects of IL-4 and IL-7 on pre-B cells transformed with a temperature-sensitive v-Abl mutant were examined.
1	To	to	PART	TO	_	_	_	_	_
2	determine	determine	VERB	VB	VerbForm=Inf	_	_	_	_
3	whether	whether	SCONJ	IN	_	_	_	_	_
4	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
5	of	of	ADP	IN	_	_	_	_	_
6	these	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
7	cytokine	cytokine	NOUN	NN	Number=Sing	_	_	_	_
8	signaling	signal	VERB	VBG	VerbForm=Ger	_	_	_	_
9	pathways	pathway	NOUN	NNS	Number=Plur	_	_	_	_
10	by	by	ADP	IN	_	_	_	_	_
11	v	v	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
12	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
13	Abl	Abl	PROPN	NNP	Number=Sing	_	_	_	_
14	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
15	important	important	ADJ	JJ	Degree=Pos	_	_	_	_
16	in	in	ADP	IN	_	_	_	_	_
17	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
18	cellular	cellular	ADJ	JJ	Degree=Pos	_	_	_	_
19	events	event	NOUN	NNS	Number=Plur	_	_	_	_
20	induced	induce	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
21	by	by	ADP	IN	_	_	_	_	_
22	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
23	Abelson	Abelson	PROPN	NNP	Number=Sing	_	_	_	_
24	murine	murine	NOUN	NN	Number=Sing	_	_	_	_
25	leukemia	leukemia	NOUN	NN	Number=Sing	_	_	_	_
26	virus	virus	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
27	,	,	PUNCT	,	_	_	_	_	_
28	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
29	effects	effect	NOUN	NNS	Number=Plur	_	_	_	_
30	of	of	ADP	IN	_	_	_	_	_
31	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
32	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
33	4	4	NUM	CD	NumType=Card	_	_	_	_
34	and	and	CCONJ	CC	_	_	_	_	_
35	IL	Il	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
36	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
37	7	7	NUM	CD	NumType=Card	_	_	_	_
38	on	on	ADP	IN	_	_	_	_	_
39	pre	pre	X	AFX	_	_	_	_	SpaceAfter=No
40	-B	-b	ADJ	JJ	Degree=Pos	_	_	_	_
41	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
42	transformed	transform	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
43	with	with	ADP	IN	_	_	_	_	_
44	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
45	temperature	temperature	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
46	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
47	sensitive	sensitive	ADJ	JJ	Degree=Pos	_	_	_	_
48	v	v	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
49	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
50	Abl	Abl	PROPN	NNP	Number=Sing	_	_	_	_
51	mutant	mutant	NOUN	NN	Number=Sing	_	_	_	_
52	were	be	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
53	examined	examin	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	SpaceAfter=No
54	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1227
# text = Whereas IL-4 had little or no effect, IL-7 delayed both the apoptosis and cell cycle arrest that occur upon v-Abl kinase inactivation.
1	Whereas	whereas	PROPN	NNP	Number=Sing	_	_	_	_
2	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
3	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
4	4	4	NUM	CD	NumType=Card	_	_	_	_
5	had	have	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
6	little	little	ADJ	JJ	Degree=Pos	_	_	_	_
7	or	or	CCONJ	CC	_	_	_	_	_
8	no	no	DET	DT	_	_	_	_	_
9	effect	effect	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
10	,	,	PUNCT	,	_	_	_	_	_
11	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
12	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
13	7	7	NUM	CD	NumType=Card	_	_	_	_
14	delayed	delay	ADJ	JJ	Degree=Pos	_	_	_	_
15	both	both	CCONJ	CC	_	_	_	_	_
16	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
17	apoptosis	apoptosis	NOUN	NN	Number=Sing	_	_	_	_
18	and	and	CCONJ	CC	_	_	_	_	_
19	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
20	cycle	cycle	NOUN	NN	Number=Sing	_	_	_	_
21	arrest	arrest	NOUN	NN	Number=Sing	_	_	_	_
22	that	that	PRON	WDT	PronType=Rel	_	_	_	_
23	occur	occur	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
24	upon	upon	ADP	IN	_	_	_	_	_
25	v	v	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
26	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
27	Abl	Abl	NOUN	NN	Number=Sing	_	_	_	_
28	kinase	kinase	NOUN	NN	Number=Sing	_	_	_	_
29	inactivation	inactivation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
30	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1228
# text = IL-7 also delayed the decreases in the levels of c-Myc, Bcl-2, and Bcl-xL that occur upon loss of v-Abl kinase activity.
1	IL	Il	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
2	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
3	7	7	NUM	CD	NumType=Card	_	_	_	_
4	also	also	ADV	RB	_	_	_	_	_
5	delayed	delay	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
6	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
7	decreases	decrease	NOUN	NNS	Number=Plur	_	_	_	_
8	in	in	ADP	IN	_	_	_	_	_
9	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
10	levels	level	NOUN	NNS	Number=Plur	_	_	_	_
11	of	of	ADP	IN	_	_	_	_	_
12	c-	c-	SYM	NFP	_	_	_	_	SpaceAfter=No
13	Myc	Myc	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
14	,	,	PUNCT	,	_	_	_	_	_
15	Bcl	Bcl	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
16	-2	-2	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
17	,	,	PUNCT	,	_	_	_	_	_
18	and	and	CCONJ	CC	_	_	_	_	_
19	Bcl	Bcl	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
20	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
21	xL	xL	AUX	MD	VerbForm=Fin	_	_	_	_
22	that	that	PRON	DT	Number=Sing|PronType=Dem	_	_	_	_
23	occur	occur	VERB	VB	VerbForm=Inf	_	_	_	_
24	upon	upon	ADP	IN	_	_	_	_	_
25	loss	loss	NOUN	NN	Number=Sing	_	_	_	_
26	of	of	ADP	IN	_	_	_	_	_
27	v	v	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
28	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
29	Abl	Abl	NOUN	NN	Number=Sing	_	_	_	_
30	kinase	kinase	NOUN	NN	Number=Sing	_	_	_	_
31	activity	activity	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
32	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1229
# text = IL-7 did not maintain v-Abl-mediated differentiation arrest of the pre-B cells, as activation of NF-kappaB and RAG gene transcription was unaffected by IL-7.
1	IL	Il	INTJ	UH	_	_	_	_	SpaceAfter=No
2	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
3	7	7	NUM	CD	NumType=Card	_	_	_	_
4	did	do	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
5	not	not	PART	RB	_	_	_	_	_
6	maintain	maintain	VERB	VB	VerbForm=Inf	_	_	_	_
7	v-	v-	SYM	NFP	_	_	_	_	SpaceAfter=No
8	Abl	Abl	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
9	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
10	mediated	mediate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
11	differentiation	differentiation	NOUN	NN	Number=Sing	_	_	_	_
12	arrest	arrest	NOUN	NN	Number=Sing	_	_	_	_
13	of	of	ADP	IN	_	_	_	_	_
14	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
15	pre	pre	X	AFX	_	_	_	_	SpaceAfter=No
16	-B	-b	ADJ	JJ	Degree=Pos	_	_	_	_
17	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
18	,	,	PUNCT	,	_	_	_	_	_
19	as	as	SCONJ	IN	_	_	_	_	_
20	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
21	of	of	ADP	IN	_	_	_	_	_
22	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
23	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
24	kappaB	kappaB	PROPN	NNP	Number=Sing	_	_	_	_
25	and	and	CCONJ	CC	_	_	_	_	_
26	RAG	RAG	PROPN	NNP	Number=Sing	_	_	_	_
27	gene	gene	PROPN	NNP	Number=Sing	_	_	_	_
28	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
29	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
30	unaffected	unaffected	ADJ	JJ	Degree=Pos	_	_	_	_
31	by	by	ADP	IN	_	_	_	_	_
32	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
33	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
34	7	7	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
35	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1230
# text = These results identify a potential role for IL-7 signaling pathways in transformation by v-Abl while demonstrating that a combination of IL-4 and IL-7 signaling cannot substitute for an active v-Abl kinase in transformed pre-B cells.
1	These	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
2	results	result	NOUN	NNS	Number=Plur	_	_	_	_
3	identify	identify	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
4	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
5	potential	potential	ADJ	JJ	Degree=Pos	_	_	_	_
6	role	role	NOUN	NN	Number=Sing	_	_	_	_
7	for	for	ADP	IN	_	_	_	_	_
8	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
9	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
10	7	7	NUM	CD	NumType=Card	_	_	_	_
11	signaling	signaling	NOUN	NN	Number=Sing	_	_	_	_
12	pathways	pathway	NOUN	NNS	Number=Plur	_	_	_	_
13	in	in	ADP	IN	_	_	_	_	_
14	transformation	transformation	NOUN	NN	Number=Sing	_	_	_	_
15	by	by	ADP	IN	_	_	_	_	_
16	v	v	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
17	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
18	Abl	Abl	NOUN	NN	Number=Sing	_	_	_	_
19	while	while	SCONJ	IN	_	_	_	_	_
20	demonstrating	demonstrat	VERB	VBG	VerbForm=Ger	_	_	_	_
21	that	that	PRON	DT	Number=Sing|PronType=Dem	_	_	_	_
22	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
23	combination	combination	NOUN	NN	Number=Sing	_	_	_	_
24	of	of	ADP	IN	_	_	_	_	_
25	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
26	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
27	4	4	NUM	CD	NumType=Card	_	_	_	_
28	and	and	CCONJ	CC	_	_	_	_	_
29	IL	Il	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
30	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
31	7	7	NUM	CD	NumType=Card	_	_	_	_
32	signaling	signaling	NOUN	NN	Number=Sing	_	_	_	_
33	can	can	AUX	MD	VerbForm=Fin	_	_	_	SpaceAfter=No
34	not	not	PART	RB	_	_	_	_	_
35	substitute	substitute	VERB	VB	VerbForm=Inf	_	_	_	_
36	for	for	ADP	IN	_	_	_	_	_
37	an	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
38	active	active	ADJ	JJ	Degree=Pos	_	_	_	_
39	v	v	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
40	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
41	Abl	Abl	NOUN	NN	Number=Sing	_	_	_	_
42	kinase	kinase	NOUN	NN	Number=Sing	_	_	_	_
43	in	in	ADP	IN	_	_	_	_	_
44	transformed	transform	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
45	pre	pre	X	AFX	_	_	_	_	SpaceAfter=No
46	-B	-b	ADJ	JJ	Degree=Pos	_	_	_	_
47	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
48	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 1231
# text = Document 003002431 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	003002431	003002431	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 1232
# text = Constitutive activation of NF-kappaB in primary adult T-cell leukemia cells.
1	Constitutive	Constitutive	ADJ	JJ	Degree=Pos	_	_	_	_
2	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
3	of	of	ADP	IN	_	_	_	_	_
4	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
5	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
6	kappaB	kappaB	PROPN	NNP	Number=Sing	_	_	_	_
7	in	in	ADP	IN	_	_	_	_	_
8	primary	primary	ADJ	JJ	Degree=Pos	_	_	_	_
9	adult	adult	NOUN	NN	Number=Sing	_	_	_	_
10	T-	T-	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
11	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
12	leukemia	leukemia	NOUN	NN	Number=Sing	_	_	_	_
13	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
14	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 1233
# text = Human T-cell leukemia virus type I (HTLV-I) is an etiologic agent of adult T-cell leukemia (ATL).
1	Human	human	ADJ	JJ	Degree=Pos	_	_	_	_
2	T-	t-	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
3	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
4	leukemia	leukemia	NOUN	NN	Number=Sing	_	_	_	_
5	virus	virus	NOUN	NN	Number=Sing	_	_	_	_
6	type	type	NOUN	NN	Number=Sing	_	_	_	_
7	I	I	PRON	PRP	Case=Nom|Number=Sing|Person=1|PronType=Prs	_	_	_	_
8	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
9	HTLV	HTLV	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
10	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
11	I	I	PRON	PRP	Case=Nom|Number=Sing|Person=1|PronType=Prs	_	_	_	SpaceAfter=No
12	)	)	PUNCT	-RRB-	_	_	_	_	_
13	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
14	an	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
15	etiologic	etiologic	ADJ	JJ	Degree=Pos	_	_	_	_
16	agent	agent	NOUN	NN	Number=Sing	_	_	_	_
17	of	of	ADP	IN	_	_	_	_	_
18	adult	adult	NOUN	NN	Number=Sing	_	_	_	_
19	T-	T-	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
20	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
21	leukemia	leukemia	NOUN	NN	Number=Sing	_	_	_	_
22	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
23	ATL	ATL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
24	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
25	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1234
# text = The viral protein Tax induces the activation and nuclear translocalization of transcription factor NF-kappaB, which is proposed to play a crucial role in the transformation of T cells by HTLV-I.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	viral	viral	ADJ	JJ	Degree=Pos	_	_	_	_
3	protein	protein	NOUN	NN	Number=Sing	_	_	_	_
4	Tax	tax	NOUN	NN	Number=Sing	_	_	_	_
5	induces	induce	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
6	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
7	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
8	and	and	CCONJ	CC	_	_	_	_	_
9	nuclear	nuclear	ADJ	JJ	Degree=Pos	_	_	_	_
10	translocalization	translocalization	NOUN	NN	Number=Sing	_	_	_	_
11	of	of	ADP	IN	_	_	_	_	_
12	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
13	factor	factor	NOUN	NN	Number=Sing	_	_	_	_
14	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
15	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
16	kappaB	kappaB	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
17	,	,	PUNCT	,	_	_	_	_	_
18	which	which	PRON	WDT	PronType=Rel	_	_	_	_
19	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
20	proposed	propose	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
21	to	to	PART	TO	_	_	_	_	_
22	play	play	VERB	VB	VerbForm=Inf	_	_	_	_
23	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
24	crucial	crucial	ADJ	JJ	Degree=Pos	_	_	_	_
25	role	role	NOUN	NN	Number=Sing	_	_	_	_
26	in	in	ADP	IN	_	_	_	_	_
27	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
28	transformation	transformation	NOUN	NN	Number=Sing	_	_	_	_
29	of	of	ADP	IN	_	_	_	_	_
30	T	t	PROPN	NNP	Number=Sing	_	_	_	_
31	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
32	by	by	ADP	IN	_	_	_	_	_
33	HTLV	HTLV	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
34	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
35	I	I	PRON	PRP	Case=Nom|Number=Sing|Person=1|PronType=Prs	_	_	_	SpaceAfter=No
36	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1235
# text = However, the HTLV-I genes including Tax are not expressed significantly in primary leukemic cells from ATL patients.
1	However	however	ADV	RB	_	_	_	_	SpaceAfter=No
2	,	,	PUNCT	,	_	_	_	_	_
3	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
4	HTLV	Htlv	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
5	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
6	I	I	PRON	PRP	Case=Nom|Number=Sing|Person=1|PronType=Prs	_	_	_	_
7	genes	gene	NOUN	NNS	Number=Plur	_	_	_	_
8	including	include	VERB	VBG	VerbForm=Ger	_	_	_	_
9	Tax	tax	NOUN	NN	Number=Sing	_	_	_	_
10	are	be	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
11	not	not	PART	RB	_	_	_	_	_
12	expressed	express	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
13	significantly	significantly	ADV	RB	_	_	_	_	_
14	in	in	ADP	IN	_	_	_	_	_
15	primary	primary	ADJ	JJ	Degree=Pos	_	_	_	_
16	leukemic	leukemic	ADJ	JJ	Degree=Pos	_	_	_	_
17	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
18	from	from	ADP	IN	_	_	_	_	_
19	ATL	Atl	ADJ	JJ	Degree=Pos	_	_	_	_
20	patients	patient	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
21	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1236
# text = In this study, we examined the basis for NF-kappaB activation in freshly isolated leukemic cells from ATL patients.
1	In	in	ADP	IN	_	_	_	_	_
2	this	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
3	study	study	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
4	,	,	PUNCT	,	_	_	_	_	_
5	we	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
6	examined	examin	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
7	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
8	basis	basis	NOUN	NN	Number=Sing	_	_	_	_
9	for	for	ADP	IN	_	_	_	_	_
10	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
11	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
12	kappaB	kappaB	PROPN	NNP	Number=Sing	_	_	_	_
13	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
14	in	in	ADP	IN	_	_	_	_	_
15	freshly	freshly	ADV	RB	_	_	_	_	_
16	isolated	isolate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
17	leukemic	leukemic	ADJ	JJ	Degree=Pos	_	_	_	_
18	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
19	from	from	ADP	IN	_	_	_	_	_
20	ATL	ATL	PROPN	NNP	Number=Sing	_	_	_	_
21	patients	patient	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
22	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1237
# text = We found that leukemic cells from ATL patients, like HTLV-I-infected T-cell lines, display constitutive NF-kappaB DNA binding activity and increased degradation of IkappaBalpha (an inhibitor of NF-kappaB).
1	We	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
2	found	find	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
3	that	that	SCONJ	IN	_	_	_	_	_
4	leukemic	leukemic	ADJ	JJ	Degree=Pos	_	_	_	_
5	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
6	from	from	ADP	IN	_	_	_	_	_
7	ATL	ATL	ADJ	JJ	Degree=Pos	_	_	_	_
8	patients	patient	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
9	,	,	PUNCT	,	_	_	_	_	_
10	like	like	ADP	IN	_	_	_	_	_
11	HTLV	HTLV	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
12	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
13	I-	I-	PUNCT	:	_	_	_	_	SpaceAfter=No
14	infected	infect	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
15	T-	t-	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
16	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
17	lines	line	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
18	,	,	PUNCT	,	_	_	_	_	_
19	display	display	NOUN	NN	Number=Sing	_	_	_	_
20	constitutive	constitutive	ADJ	JJ	Degree=Pos	_	_	_	_
21	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
22	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
23	kappaB	kappaB	PROPN	NNP	Number=Sing	_	_	_	_
24	DNA	dna	NOUN	NN	Number=Sing	_	_	_	_
25	binding	binde	VERB	VBG	VerbForm=Ger	_	_	_	_
26	activity	activity	NOUN	NN	Number=Sing	_	_	_	_
27	and	and	CCONJ	CC	_	_	_	_	_
28	increased	increase	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
29	degradation	degradation	NOUN	NN	Number=Sing	_	_	_	_
30	of	of	ADP	IN	_	_	_	_	_
31	IkappaBalpha	IkappaBalpha	PROPN	NNP	Number=Sing	_	_	_	_
32	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
33	an	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
34	inhibitor	inhibitor	NOUN	NN	Number=Sing	_	_	_	_
35	of	of	ADP	IN	_	_	_	_	_
36	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
37	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
38	kappaB	kappaB	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
39	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
40	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1238
# text = Whereas the NF-kappaB binding activity in Tax-expressing T-cell lines consisted mostly of p50/c-Rel, fresh ATL samples contained p50/p50 and p50/p65 heterodimers.
1	Whereas	whereas	SCONJ	IN	_	_	_	_	_
2	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
3	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
4	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
5	kappaB	kappaB	PROPN	NNP	Number=Sing	_	_	_	_
6	binding	bind	VERB	VBG	VerbForm=Ger	_	_	_	_
7	activity	activity	NOUN	NN	Number=Sing	_	_	_	_
8	in	in	ADP	IN	_	_	_	_	_
9	Tax	tax	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
10	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
11	expressing	expresse	VERB	VBG	VerbForm=Ger	_	_	_	_
12	T-	t-	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
13	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
14	lines	line	NOUN	NNS	Number=Plur	_	_	_	_
15	consisted	consist	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
16	mostly	mostly	ADV	RB	_	_	_	_	_
17	of	of	ADP	IN	_	_	_	_	_
18	p50/c	p50/c	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
19	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
20	Rel	Rel	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
21	,	,	PUNCT	,	_	_	_	_	_
22	fresh	fresh	ADJ	JJ	Degree=Pos	_	_	_	_
23	ATL	Atl	ADJ	JJ	Degree=Pos	_	_	_	_
24	samples	sample	NOUN	NNS	Number=Plur	_	_	_	_
25	contained	contain	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
26	p50/p50	p50/p50	NUM	CD	NumType=Card	_	_	_	_
27	and	and	CCONJ	CC	_	_	_	_	_
28	p50	p50	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
29	/	/	SYM	SYM	_	_	_	_	SpaceAfter=No
30	p65	p65	NUM	CD	NumType=Card	_	_	_	_
31	heterodimers	heterodimer	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
32	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1239
# text = One T-cell line derived from ATL leukemic cells, TL-Om1, displayed constitutive NF-kappaB activity, as well as enhanced degradation of IkappaBalpha, despite the lack of detectable Tax expression.
1	One	one	NUM	CD	NumType=Card	_	_	_	_
2	T-	T-	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
3	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
4	line	line	NOUN	NN	Number=Sing	_	_	_	_
5	derived	derive	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
6	from	from	ADP	IN	_	_	_	_	_
7	ATL	ATL	PROPN	NNP	Number=Sing	_	_	_	_
8	leukemic	leukemic	ADJ	JJ	Degree=Pos	_	_	_	_
9	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
10	,	,	PUNCT	,	_	_	_	_	_
11	TL	TL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
12	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
13	Om1	Om1	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
14	,	,	PUNCT	,	_	_	_	_	_
15	displayed	display	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
16	constitutive	constitutive	ADJ	JJ	Degree=Pos	_	_	_	_
17	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
18	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
19	kappaB	kappaB	PROPN	NNP	Number=Sing	_	_	_	_
20	activity	activity	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
21	,	,	PUNCT	,	_	_	_	_	_
22	as	as	ADV	RB	_	_	_	_	_
23	well	well	ADV	RB	Degree=Pos	_	_	_	_
24	as	as	ADP	IN	_	_	_	_	_
25	enhanced	enhance	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
26	degradation	degradation	NOUN	NN	Number=Sing	_	_	_	_
27	of	of	ADP	IN	_	_	_	_	_
28	IkappaBalpha	IkappaBalpha	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
29	,	,	PUNCT	,	_	_	_	_	_
30	despite	despite	ADP	IN	_	_	_	_	_
31	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
32	lack	lack	NOUN	NN	Number=Sing	_	_	_	_
33	of	of	ADP	IN	_	_	_	_	_
34	detectable	detectable	ADJ	JJ	Degree=Pos	_	_	_	_
35	Tax	tax	NOUN	NN	Number=Sing	_	_	_	_
36	expression	expression	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
37	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1240
# text = Interestingly, the NF-kappaB in TL-Om1 consists of p50/p50 and p50/p65 like that in fresh primary leukemic cells.
1	Interestingly	Interestingly	ADV	RB	_	_	_	_	SpaceAfter=No
2	,	,	PUNCT	,	_	_	_	_	_
3	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
4	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
5	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
6	kappaB	kappaB	PROPN	NNP	Number=Sing	_	_	_	_
7	in	in	ADP	IN	_	_	_	_	_
8	TL	TL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
9	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
10	Om1	Om1	NUM	CD	NumType=Card	_	_	_	_
11	consists	consist	NOUN	NNS	Number=Plur	_	_	_	_
12	of	of	ADP	IN	_	_	_	_	_
13	p50/	p50/	SYM	NFP	_	_	_	_	SpaceAfter=No
14	p50	p50	NUM	CD	NumType=Card	_	_	_	_
15	and	and	CCONJ	CC	_	_	_	_	_
16	p50	p50	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
17	/	/	SYM	SYM	_	_	_	_	SpaceAfter=No
18	p65	p65	NUM	CD	NumType=Card	_	_	_	_
19	like	like	ADP	IN	_	_	_	_	_
20	that	that	PRON	DT	Number=Sing|PronType=Dem	_	_	_	_
21	in	in	ADP	IN	_	_	_	_	_
22	fresh	fresh	ADJ	JJ	Degree=Pos	_	_	_	_
23	primary	primary	ADJ	JJ	Degree=Pos	_	_	_	_
24	leukemic	leukemic	ADJ	JJ	Degree=Pos	_	_	_	_
25	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
26	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1241
# text = Our results suggest that activation of NF-kappaB occurs through a Tax-independent mechanism in leukemic cells of ATL patients, possibly due to differential NF-kappaB subunit activation.
1	Our	we	PRON	PRP$	Number=Plur|Person=1|Poss=Yes|PronType=Prs	_	_	_	_
2	results	result	NOUN	NNS	Number=Plur	_	_	_	_
3	suggest	suggest	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
4	that	that	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
5	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
6	of	of	ADP	IN	_	_	_	_	_
7	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
8	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
9	kappaB	kappaB	PROPN	NNP	Number=Sing	_	_	_	_
10	occurs	occur	NOUN	NNS	Number=Plur	_	_	_	_
11	through	through	ADP	IN	_	_	_	_	_
12	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
13	Tax	tax	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
14	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
15	independent	independent	ADJ	JJ	Degree=Pos	_	_	_	_
16	mechanism	mechanism	NOUN	NN	Number=Sing	_	_	_	_
17	in	in	ADP	IN	_	_	_	_	_
18	leukemic	leukemic	ADJ	JJ	Degree=Pos	_	_	_	_
19	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
20	of	of	ADP	IN	_	_	_	_	_
21	ATL	Atl	ADJ	JJ	Degree=Pos	_	_	_	_
22	patients	patient	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
23	,	,	PUNCT	,	_	_	_	_	_
24	possibly	possibly	ADV	RB	_	_	_	_	_
25	due	due	ADP	IN	_	_	_	_	_
26	to	to	ADP	IN	_	_	_	_	_
27	differential	differential	ADJ	JJ	Degree=Pos	_	_	_	_
28	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
29	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
30	kappaB	kappaB	PROPN	NNP	Number=Sing	_	_	_	_
31	subunit	subunit	NOUN	NN	Number=Sing	_	_	_	_
32	activation	activation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
33	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 1242
# text = Document 003002435 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	003002435	003002435	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 1243
# text = The retinoblastoma gene product negatively regulates transcriptional activation mediated by the human cytomegalovirus IE2 protein.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	retinoblastoma	retinoblastoma	NOUN	NN	Number=Sing	_	_	_	_
3	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
4	product	product	NOUN	NN	Number=Sing	_	_	_	_
5	negatively	negatively	ADV	RB	_	_	_	_	_
6	regulates	regulate	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
7	transcriptional	transcriptional	ADJ	JJ	Degree=Pos	_	_	_	_
8	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
9	mediated	mediate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
10	by	by	ADP	IN	_	_	_	_	_
11	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
12	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
13	cytomegalovirus	cytomegalovirus	NOUN	NN	Number=Sing	_	_	_	_
14	IE2	Ie2	NUM	CD	NumType=Card	_	_	_	_
15	protein	protein	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
16	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 1244
# text = The IE2 gene product of human cytomegalovirus (HCMV) is one of a few viral regulatory proteins expressed immediately upon infection of the host cell.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	IE2	IE2	NUM	CD	NumType=Card	_	_	_	_
3	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
4	product	product	NOUN	NN	Number=Sing	_	_	_	_
5	of	of	ADP	IN	_	_	_	_	_
6	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
7	cytomegalovirus	cytomegalovirus	NOUN	NN	Number=Sing	_	_	_	_
8	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
9	HCMV	HCMV	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
10	)	)	PUNCT	-RRB-	_	_	_	_	_
11	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
12	one	one	NUM	CD	NumType=Card	_	_	_	_
13	of	of	ADP	IN	_	_	_	_	_
14	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
15	few	few	ADJ	JJ	Degree=Pos	_	_	_	_
16	viral	viral	ADJ	JJ	Degree=Pos	_	_	_	_
17	regulatory	regulatory	ADJ	JJ	Degree=Pos	_	_	_	_
18	proteins	protein	NOUN	NNS	Number=Plur	_	_	_	_
19	expressed	express	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
20	immediately	immediately	ADV	RB	_	_	_	_	_
21	upon	upon	ADP	IN	_	_	_	_	_
22	infection	infection	NOUN	NN	Number=Sing	_	_	_	_
23	of	of	ADP	IN	_	_	_	_	_
24	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
25	host	host	NOUN	NN	Number=Sing	_	_	_	_
26	cell	cell	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
27	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1245
# text = It is a potent transcriptional activator of many viral and cellular promoters.
1	It	it	PRON	PRP	Case=Nom|Gender=Neut|Number=Sing|Person=3|PronType=Prs	_	_	_	_
2	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
3	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
4	potent	potent	NOUN	NN	Number=Sing	_	_	_	_
5	transcriptional	transcriptional	ADJ	JJ	Degree=Pos	_	_	_	_
6	activator	activator	NOUN	NN	Number=Sing	_	_	_	_
7	of	of	ADP	IN	_	_	_	_	_
8	many	many	ADJ	JJ	Degree=Pos	_	_	_	_
9	viral	viral	ADJ	JJ	Degree=Pos	_	_	_	_
10	and	and	CCONJ	CC	_	_	_	_	_
11	cellular	cellular	ADJ	JJ	Degree=Pos	_	_	_	_
12	promoters	promoter	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
13	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1246
# text = We found that the retinoblastoma susceptibility gene product (Rb) dramatically suppressed this IE2 transactivation of various promoters.
1	We	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
2	found	find	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
3	that	that	SCONJ	IN	_	_	_	_	_
4	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
5	retinoblastoma	retinoblastoma	NOUN	NN	Number=Sing	_	_	_	_
6	susceptibility	susceptibility	NOUN	NN	Number=Sing	_	_	_	_
7	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
8	product	product	NOUN	NN	Number=Sing	_	_	_	_
9	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
10	Rb	Rb	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
11	)	)	PUNCT	-RRB-	_	_	_	_	_
12	dramatically	dramatically	ADV	RB	_	_	_	_	_
13	suppressed	suppress	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
14	this	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
15	IE2	IE2	NOUN	NN	Number=Sing	_	_	_	_
16	transactivation	transactivation	NOUN	NN	Number=Sing	_	_	_	_
17	of	of	ADP	IN	_	_	_	_	_
18	various	various	ADJ	JJ	Degree=Pos	_	_	_	_
19	promoters	promoter	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
20	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1247
# text = However, unlike another tumor suppressor protein, p53, Rb did not have any significant effect on basal levels of transcription, suggesting that Rb specifically interacts with IE2 rather than other cellular factors involved in the general transcription machinery.
1	However	however	ADV	RB	_	_	_	_	SpaceAfter=No
2	,	,	PUNCT	,	_	_	_	_	_
3	unlike	unlike	ADP	IN	_	_	_	_	_
4	another	another	DET	DT	_	_	_	_	_
5	tumor	tumor	NOUN	NN	Number=Sing	_	_	_	_
6	suppressor	suppressor	NOUN	NN	Number=Sing	_	_	_	_
7	protein	protein	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
8	,	,	PUNCT	,	_	_	_	_	_
9	p53	p53	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
10	,	,	PUNCT	,	_	_	_	_	_
11	Rb	Rb	PROPN	NNP	Number=Sing	_	_	_	_
12	did	do	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
13	not	not	PART	RB	_	_	_	_	_
14	have	have	VERB	VB	VerbForm=Inf	_	_	_	_
15	any	any	DET	DT	_	_	_	_	_
16	significant	significant	ADJ	JJ	Degree=Pos	_	_	_	_
17	effect	effect	NOUN	NN	Number=Sing	_	_	_	_
18	on	on	ADP	IN	_	_	_	_	_
19	basal	basal	ADJ	JJ	Degree=Pos	_	_	_	_
20	levels	level	NOUN	NNS	Number=Plur	_	_	_	_
21	of	of	ADP	IN	_	_	_	_	_
22	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
23	,	,	PUNCT	,	_	_	_	_	_
24	suggesting	suggest	VERB	VBG	VerbForm=Ger	_	_	_	_
25	that	that	SCONJ	IN	_	_	_	_	_
26	Rb	Rb	PROPN	NNP	Number=Sing	_	_	_	_
27	specifically	specifically	ADV	RB	_	_	_	_	_
28	interacts	interact	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
29	with	with	ADP	IN	_	_	_	_	_
30	IE2	Ie2	NUM	CD	NumType=Card	_	_	_	_
31	rather	rather	ADV	RB	_	_	_	_	_
32	than	than	ADP	IN	_	_	_	_	_
33	other	other	ADJ	JJ	Degree=Pos	_	_	_	_
34	cellular	cellular	ADJ	JJ	Degree=Pos	_	_	_	_
35	factors	factor	NOUN	NNS	Number=Plur	_	_	_	_
36	involved	involve	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
37	in	in	ADP	IN	_	_	_	_	_
38	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
39	general	general	ADJ	JJ	Degree=Pos	_	_	_	_
40	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
41	machinery	machinery	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
42	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1248
# text = We found by protein-affinity chromatography that Rb in nuclear extracts or produced by in vitro translation directly bound to IE2.
1	We	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
2	found	find	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
3	by	by	ADP	IN	_	_	_	_	_
4	protein-	protein-	SYM	NFP	_	_	_	_	SpaceAfter=No
5	affinity	affinity	NOUN	NN	Number=Sing	_	_	_	_
6	chromatography	chromatography	NOUN	NN	Number=Sing	_	_	_	_
7	that	that	PRON	WDT	PronType=Rel	_	_	_	_
8	Rb	Rb	PROPN	NNP	Number=Sing	_	_	_	_
9	in	in	ADP	IN	_	_	_	_	_
10	nuclear	nuclear	ADJ	JJ	Degree=Pos	_	_	_	_
11	extracts	extract	NOUN	NNS	Number=Plur	_	_	_	_
12	or	or	CCONJ	CC	_	_	_	_	_
13	produced	produce	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
14	by	by	ADP	IN	_	_	_	_	_
15	in	in	ADP	IN	_	_	_	_	_
16	vitro	vitro	NOUN	NN	Number=Sing	_	_	_	_
17	translation	translation	NOUN	NN	Number=Sing	_	_	_	_
18	directly	directly	ADV	RB	_	_	_	_	_
19	bound	bound	ADJ	JJ	Degree=Pos	_	_	_	_
20	to	to	ADP	IN	_	_	_	_	_
21	IE2	IE2	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
22	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1249
# text = Our results suggest that Rb may regulate the life cycle of HCMV, which is endemic in the human population.
1	Our	we	PRON	PRP$	Number=Plur|Person=1|Poss=Yes|PronType=Prs	_	_	_	_
2	results	result	NOUN	NNS	Number=Plur	_	_	_	_
3	suggest	suggest	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
4	that	that	SCONJ	IN	_	_	_	_	_
5	Rb	Rb	PROPN	NNP	Number=Sing	_	_	_	_
6	may	may	AUX	MD	VerbForm=Fin	_	_	_	_
7	regulate	regulate	VERB	VB	VerbForm=Inf	_	_	_	_
8	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
9	life	life	NOUN	NN	Number=Sing	_	_	_	_
10	cycle	cycle	NOUN	NN	Number=Sing	_	_	_	_
11	of	of	ADP	IN	_	_	_	_	_
12	HCMV	HCMV	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
13	,	,	PUNCT	,	_	_	_	_	_
14	which	which	PRON	WDT	PronType=Rel	_	_	_	_
15	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
16	endemic	endemic	ADJ	JJ	Degree=Pos	_	_	_	_
17	in	in	ADP	IN	_	_	_	_	_
18	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
19	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
20	population	population	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
21	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1250
# text = Furthermore, these data may provide new insights into the slow rate of HCMV DNA replication in cells and the possible involvement of HCMV in tumorigenesis.
1	Furthermore	furthermore	ADV	RB	_	_	_	_	SpaceAfter=No
2	,	,	PUNCT	,	_	_	_	_	_
3	these	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
4	data	data	NOUN	NN	Number=Sing	_	_	_	_
5	may	may	AUX	MD	VerbForm=Fin	_	_	_	_
6	provide	provide	VERB	VB	VerbForm=Inf	_	_	_	_
7	new	new	ADJ	JJ	Degree=Pos	_	_	_	_
8	insights	insight	NOUN	NNS	Number=Plur	_	_	_	_
9	into	into	ADP	IN	_	_	_	_	_
10	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
11	slow	slow	ADJ	JJ	Degree=Pos	_	_	_	_
12	rate	rate	NOUN	NN	Number=Sing	_	_	_	_
13	of	of	ADP	IN	_	_	_	_	_
14	HCMV	Hcmv	NOUN	NN	Number=Sing	_	_	_	_
15	DNA	dna	NOUN	NN	Number=Sing	_	_	_	_
16	replication	replication	NOUN	NN	Number=Sing	_	_	_	_
17	in	in	ADP	IN	_	_	_	_	_
18	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
19	and	and	CCONJ	CC	_	_	_	_	_
20	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
21	possible	possible	ADJ	JJ	Degree=Pos	_	_	_	_
22	involvement	involvement	NOUN	NN	Number=Sing	_	_	_	_
23	of	of	ADP	IN	_	_	_	_	_
24	HCMV	HCMV	PROPN	NNP	Number=Sing	_	_	_	_
25	in	in	ADP	IN	_	_	_	_	_
26	tumorigenesis	tumorigenesis	PRON	DT	Number=Sing|PronType=Dem	_	_	_	SpaceAfter=No
27	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 1251
# text = Document 003002440 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	003002440	003002440	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 1252
# text = Regulation of Fas ligand expression and cell death by apoptosis-linked gene 4.
1	Regulation	regulation	NOUN	NN	Number=Sing	_	_	_	_
2	of	of	ADP	IN	_	_	_	_	_
3	Fas	Fas	PROPN	NNP	Number=Sing	_	_	_	_
4	ligand	ligand	NOUN	NN	Number=Sing	_	_	_	_
5	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
6	and	and	CCONJ	CC	_	_	_	_	_
7	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
8	death	death	NOUN	NN	Number=Sing	_	_	_	_
9	by	by	ADP	IN	_	_	_	_	_
10	apoptosis	apoptosis	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
11	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
12	linked	link	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
13	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
14	4	4	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
15	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 1253
# text = Programmed cell death is a process required for the normal development of an organism.
1	Programmed	programmed	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
2	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
3	death	death	NOUN	NN	Number=Sing	_	_	_	_
4	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
5	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
6	process	process	NOUN	NN	Number=Sing	_	_	_	_
7	required	require	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
8	for	for	ADP	IN	_	_	_	_	_
9	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
10	normal	normal	ADJ	JJ	Degree=Pos	_	_	_	_
11	development	development	NOUN	NN	Number=Sing	_	_	_	_
12	of	of	ADP	IN	_	_	_	_	_
13	an	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
14	organism	organism	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
15	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1254
# text = One of the best understood apoptotic pathways occurs in T lymphocytes and is mediated by Fas/Fas ligand (FasL) interaction.
1	One	one	NUM	CD	NumType=Card	_	_	_	_
2	of	of	ADP	IN	_	_	_	_	_
3	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
4	best	best	ADJ	JJS	Degree=Sup	_	_	_	_
5	understood	understand	NOUN	NN	Number=Sing	_	_	_	_
6	apoptotic	apoptotic	ADJ	JJ	Degree=Pos	_	_	_	_
7	pathways	pathway	NOUN	NNS	Number=Plur	_	_	_	_
8	occurs	occur	NOUN	NNS	Number=Plur	_	_	_	_
9	in	in	ADP	IN	_	_	_	_	_
10	T	T	PROPN	NNP	Number=Sing	_	_	_	_
11	lymphocytes	lymphocyte	NOUN	NNS	Number=Plur	_	_	_	_
12	and	and	CCONJ	CC	_	_	_	_	_
13	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
14	mediated	mediate	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
15	by	by	ADP	IN	_	_	_	_	_
16	Fas	Fas	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
17	/	/	PUNCT	,	_	_	_	_	SpaceAfter=No
18	Fas	Fas	PROPN	NNP	Number=Sing	_	_	_	_
19	ligand	ligand	NOUN	NN	Number=Sing	_	_	_	_
20	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
21	FasL	FasL	INTJ	UH	_	_	_	_	SpaceAfter=No
22	)	)	PUNCT	-RRB-	_	_	_	_	_
23	interaction	interaction	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
24	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1255
# text = During studies of apoptosis induced by T cell-receptor engagement, we identified ALG-4F, a truncated transcript that prevents T cell-receptor-induced FasL upregulation and cell death.
1	During	during	ADP	IN	_	_	_	_	_
2	studies	study	NOUN	NNS	Number=Plur	_	_	_	_
3	of	of	ADP	IN	_	_	_	_	_
4	apoptosis	apoptosis	NOUN	NN	Number=Sing	_	_	_	_
5	induced	induce	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
6	by	by	ADP	IN	_	_	_	_	_
7	T	T	PROPN	NNP	Number=Sing	_	_	_	_
8	cell	cell	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
9	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
10	receptor	receptor	NOUN	NN	Number=Sing	_	_	_	_
11	engagement	engagement	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
12	,	,	PUNCT	,	_	_	_	_	_
13	we	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
14	identified	identify	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
15	ALG	ALG	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
16	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
17	4F	4F	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
18	,	,	PUNCT	,	_	_	_	_	_
19	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
20	truncated	truncate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
21	transcript	transcript	NOUN	NN	Number=Sing	_	_	_	_
22	that	that	PRON	WDT	PronType=Rel	_	_	_	_
23	prevents	prevent	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
24	T	T	PROPN	NNP	Number=Sing	_	_	_	_
25	cell	cell	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
26	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
27	receptor	receptor	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
28	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
29	induced	induce	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
30	FasL	Fasl	ADJ	JJ	Degree=Pos	_	_	_	_
31	upregulation	upregulation	NOUN	NN	Number=Sing	_	_	_	_
32	and	and	CCONJ	CC	_	_	_	_	_
33	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
34	death	death	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
35	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1256
# text = Overexpression of full-length ALG-4 induced transcription of FasL and, consequently, apoptosis.
1	Overexpression	Overexpression	NOUN	NN	Number=Sing	_	_	_	_
2	of	of	ADP	IN	_	_	_	_	_
3	full	full	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
4	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
5	length	length	NOUN	NN	Number=Sing	_	_	_	_
6	ALG	Alg	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
7	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
8	4	4	NUM	CD	NumType=Card	_	_	_	_
9	induced	induce	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
10	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
11	of	of	ADP	IN	_	_	_	_	_
12	FasL	Fasl	NOUN	NN	Number=Sing	_	_	_	_
13	and	and	CCONJ	CC	_	_	_	_	SpaceAfter=No
14	,	,	PUNCT	,	_	_	_	_	_
15	consequently	consequently	ADV	RB	_	_	_	_	SpaceAfter=No
16	,	,	PUNCT	,	_	_	_	_	_
17	apoptosis	apoptosis	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	SpaceAfter=No
18	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1257
# text = These results indicate that ALG-4 is necessary and sufficient for FasL expression.
1	These	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
2	results	result	NOUN	NNS	Number=Plur	_	_	_	_
3	indicate	indicate	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
4	that	that	SCONJ	IN	_	_	_	_	_
5	ALG	ALG	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
6	-	-	SYM	SYM	_	_	_	_	SpaceAfter=No
7	4	4	NUM	CD	NumType=Card	_	_	_	_
8	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
9	necessary	necessary	ADJ	JJ	Degree=Pos	_	_	_	_
10	and	and	CCONJ	CC	_	_	_	_	_
11	sufficient	sufficient	ADJ	JJ	Degree=Pos	_	_	_	_
12	for	for	ADP	IN	_	_	_	_	_
13	FasL	Fasl	ADJ	JJ	Degree=Pos	_	_	_	_
14	expression	expression	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
15	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1258
# text = Fas/FasL interaction initiates cell death in many other systems, and its dysregulation is a mechanism by which several pathologic conditions arise.
1	Fas	Fa	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
2	/	/	PUNCT	,	_	_	_	_	SpaceAfter=No
3	FasL	Fasl	ADJ	JJ	Degree=Pos	_	_	_	_
4	interaction	interaction	NOUN	NN	Number=Sing	_	_	_	_
5	initiates	initiate	NOUN	NNS	Number=Plur	_	_	_	_
6	cell	cell	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
7	death	death	NOUN	NN	Number=Sing	_	_	_	_
8	in	in	ADP	IN	_	_	_	_	_
9	many	many	ADJ	JJ	Degree=Pos	_	_	_	_
10	other	other	ADJ	JJ	Degree=Pos	_	_	_	_
11	systems	system	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
12	,	,	PUNCT	,	_	_	_	_	_
13	and	and	CCONJ	CC	_	_	_	_	_
14	its	its	PRON	PRP$	Gender=Neut|Number=Sing|Person=3|Poss=Yes|PronType=Prs	_	_	_	_
15	dysregulation	dysregulation	NOUN	NN	Number=Sing	_	_	_	_
16	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
17	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
18	mechanism	mechanism	NOUN	NN	Number=Sing	_	_	_	_
19	by	by	ADP	IN	_	_	_	_	_
20	which	which	PRON	WDT	PronType=Rel	_	_	_	_
21	several	several	ADJ	JJ	Degree=Pos	_	_	_	_
22	pathologic	pathologic	NOUN	NN	Number=Sing	_	_	_	_
23	conditions	condition	NOUN	NNS	Number=Plur	_	_	_	_
24	arise	arise	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	SpaceAfter=No
25	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1259
# text = Understanding the molecular mechanisms of FasL regulation could be very useful in elucidating how these diseases develop and in identifying potential therapeutic targets.
1	Understanding	understand	VERB	VBG	VerbForm=Ger	_	_	_	_
2	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
3	molecular	molecular	ADJ	JJ	Degree=Pos	_	_	_	_
4	mechanisms	mechanism	NOUN	NNS	Number=Plur	_	_	_	_
5	of	of	ADP	IN	_	_	_	_	_
6	FasL	Fasl	ADJ	JJ	Degree=Pos	_	_	_	_
7	regulation	regulation	NOUN	NN	Number=Sing	_	_	_	_
8	could	could	AUX	MD	VerbForm=Fin	_	_	_	_
9	be	be	AUX	VB	VerbForm=Inf	_	_	_	_
10	very	very	ADV	RB	_	_	_	_	_
11	useful	useful	ADJ	JJ	Degree=Pos	_	_	_	_
12	in	in	SCONJ	IN	_	_	_	_	_
13	elucidating	elucidat	VERB	VBG	VerbForm=Ger	_	_	_	_
14	how	how	ADV	WRB	PronType=Int	_	_	_	_
15	these	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
16	diseases	disease	NOUN	NNS	Number=Plur	_	_	_	_
17	develop	develop	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
18	and	and	CCONJ	CC	_	_	_	_	_
19	in	in	SCONJ	IN	_	_	_	_	_
20	identifying	identify	VERB	VBG	VerbForm=Ger	_	_	_	_
21	potential	potential	ADJ	JJ	Degree=Pos	_	_	_	_
22	therapeutic	therapeutic	ADJ	JJ	Degree=Pos	_	_	_	_
23	targets	target	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
24	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 1260
# text = Document 003002446 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	003002446	003002446	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 1261
# text = Inhibition of NF-AT signal transduction events by a dominant-negative form of calcineurin.
1	Inhibition	Inhibition	NOUN	NN	Number=Sing	_	_	_	_
2	of	of	ADP	IN	_	_	_	_	_
3	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
4	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
5	AT	AT	ADJ	JJ	Degree=Pos	_	_	_	_
6	signal	signal	NOUN	NN	Number=Sing	_	_	_	_
7	transduction	transduction	NOUN	NN	Number=Sing	_	_	_	_
8	events	event	NOUN	NNS	Number=Plur	_	_	_	_
9	by	by	ADP	IN	_	_	_	_	_
10	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
11	dominant	dominant	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
12	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
13	negative	negative	ADJ	JJ	Degree=Pos	_	_	_	_
14	form	form	NOUN	NN	Number=Sing	_	_	_	_
15	of	of	ADP	IN	_	_	_	_	_
16	calcineurin	calcineurin	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
17	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 1262
# text = An inhibitory, "dominant-negative," form of the calcineurin catalytic (A) subunit was prepared, which lacks the calmodulin-binding domain, autoinhibitory domain and most of its catalytic core but possesses the regulatory (B) subunit binding domain.
1	An	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
2	inhibitory	inhibitory	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
3	,	,	PUNCT	,	_	_	_	_	_
4	"	"	PUNCT	``	_	_	_	_	SpaceAfter=No
5	dominant	dominant	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
6	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
7	negative	negative	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
8	,	,	PUNCT	,	_	_	_	_	SpaceAfter=No
9	"	"	PUNCT	''	_	_	_	_	_
10	form	form	NOUN	NN	Number=Sing	_	_	_	_
11	of	of	ADP	IN	_	_	_	_	_
12	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
13	calcineurin	calcineurin	NOUN	NN	Number=Sing	_	_	_	_
14	catalytic	catalytic	ADJ	JJ	Degree=Pos	_	_	_	_
15	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
16	A	a	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
17	)	)	PUNCT	-RRB-	_	_	_	_	_
18	subunit	subunit	NOUN	NN	Number=Sing	_	_	_	_
19	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
20	prepared	prepare	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	SpaceAfter=No
21	,	,	PUNCT	,	_	_	_	_	_
22	which	which	PRON	WDT	PronType=Rel	_	_	_	_
23	lacks	lack	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
24	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
25	calmodulin	calmodulin	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
26	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
27	binding	binding	VERB	VBG	VerbForm=Ger	_	_	_	_
28	domain	domain	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
29	,	,	PUNCT	,	_	_	_	_	_
30	autoinhibitory	autoinhibitory	NOUN	NN	Number=Sing	_	_	_	_
31	domain	domain	NOUN	NN	Number=Sing	_	_	_	_
32	and	and	CCONJ	CC	_	_	_	_	_
33	most	most	ADJ	JJS	Degree=Sup	_	_	_	_
34	of	of	ADP	IN	_	_	_	_	_
35	its	its	PRON	PRP$	Gender=Neut|Number=Sing|Person=3|Poss=Yes|PronType=Prs	_	_	_	_
36	catalytic	catalytic	ADJ	JJ	Degree=Pos	_	_	_	_
37	core	core	NOUN	NN	Number=Sing	_	_	_	_
38	but	but	CCONJ	CC	_	_	_	_	_
39	possesses	possess	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
40	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
41	regulatory	regulatory	ADJ	JJ	Degree=Pos	_	_	_	_
42	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
43	B	b	X	LS	_	_	_	_	SpaceAfter=No
44	)	)	PUNCT	-RRB-	_	_	_	_	_
45	subunit	subunit	NOUN	NN	Number=Sing	_	_	_	_
46	binding	binde	VERB	VBG	VerbForm=Ger	_	_	_	_
47	domain	domain	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
48	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1263
# text = When tested for its ability to block calcineurin-dependent signaling in Jurkat cells, expression of this "B-subunit knock-out" (BKO) construct suppressed reporter gene activity driven by NF-AT, the pivotal promoter element for interleukin (IL)-2 gene induction.
1	When	when	ADV	WRB	PronType=Int	_	_	_	_
2	tested	test	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
3	for	for	ADP	IN	_	_	_	_	_
4	its	its	PRON	PRP$	Gender=Neut|Number=Sing|Person=3|Poss=Yes|PronType=Prs	_	_	_	_
5	ability	ability	NOUN	NN	Number=Sing	_	_	_	_
6	to	to	PART	TO	_	_	_	_	_
7	block	block	VERB	VB	VerbForm=Inf	_	_	_	_
8	calcineurin	calcineurin	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
9	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
10	dependent	dependent	ADJ	JJ	Degree=Pos	_	_	_	_
11	signaling	signaling	NOUN	NN	Number=Sing	_	_	_	_
12	in	in	ADP	IN	_	_	_	_	_
13	Jurkat	Jurkat	PROPN	NNP	Number=Sing	_	_	_	_
14	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
15	,	,	PUNCT	,	_	_	_	_	_
16	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
17	of	of	ADP	IN	_	_	_	_	_
18	this	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
19	"	"	PUNCT	``	_	_	_	_	SpaceAfter=No
20	B	b	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
21	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
22	subunit	subunit	NOUN	NN	Number=Sing	_	_	_	_
23	knock	knock	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
24	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
25	out	out	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
26	"	"	PUNCT	''	_	_	_	_	_
27	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
28	BKO	BKO	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
29	)	)	PUNCT	-RRB-	_	_	_	_	_
30	construct	construct	NOUN	NN	Number=Sing	_	_	_	_
31	suppressed	suppress	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
32	reporter	reporter	NOUN	NN	Number=Sing	_	_	_	_
33	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
34	activity	activity	NOUN	NN	Number=Sing	_	_	_	_
35	driven	drive	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
36	by	by	ADP	IN	_	_	_	_	_
37	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
38	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
39	AT	AT	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
40	,	,	PUNCT	,	_	_	_	_	_
41	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
42	pivotal	pivotal	ADJ	JJ	Degree=Pos	_	_	_	_
43	promoter	promoter	NOUN	NN	Number=Sing	_	_	_	_
44	element	element	NOUN	NN	Number=Sing	_	_	_	_
45	for	for	ADP	IN	_	_	_	_	_
46	interleukin	interleukin	NOUN	NN	Number=Sing	_	_	_	_
47	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
48	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
49	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
50	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
51	2	2	NUM	CD	NumType=Card	_	_	_	_
52	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
53	induction	induction	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
54	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1264
# text = Immunoprecipitation of epitope-labeled BKO demonstrated for the formation of a tight complex with endogenous B subunit in Jurkat cells, consistent with an inhibitory mechanism that involves the sequestration of the B subunit.
1	Immunoprecipitation	Immunoprecipitation	NOUN	NN	Number=Sing	_	_	_	_
2	of	of	ADP	IN	_	_	_	_	_
3	epitope	epitope	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
4	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
5	labeled	label	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
6	BKO	Bko	PROPN	NNP	Number=Sing	_	_	_	_
7	demonstrated	demonstrate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
8	for	for	ADP	IN	_	_	_	_	_
9	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
10	formation	formation	NOUN	NN	Number=Sing	_	_	_	_
11	of	of	ADP	IN	_	_	_	_	_
12	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
13	tight	tight	ADJ	JJ	Degree=Pos	_	_	_	_
14	complex	complex	NOUN	NN	Number=Sing	_	_	_	_
15	with	with	ADP	IN	_	_	_	_	_
16	endogenous	endogenous	ADJ	JJ	Degree=Pos	_	_	_	_
17	B	b	NOUN	NN	Number=Sing	_	_	_	_
18	subunit	subunit	NOUN	NN	Number=Sing	_	_	_	_
19	in	in	ADP	IN	_	_	_	_	_
20	Jurkat	Jurkat	PROPN	NNP	Number=Sing	_	_	_	_
21	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
22	,	,	PUNCT	,	_	_	_	_	_
23	consistent	consistent	ADJ	JJ	Degree=Pos	_	_	_	_
24	with	with	ADP	IN	_	_	_	_	_
25	an	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
26	inhibitory	inhibitory	ADJ	JJ	Degree=Pos	_	_	_	_
27	mechanism	mechanism	NOUN	NN	Number=Sing	_	_	_	_
28	that	that	PRON	WDT	PronType=Rel	_	_	_	_
29	involves	involve	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
30	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
31	sequestration	sequestration	NOUN	NN	Number=Sing	_	_	_	_
32	of	of	ADP	IN	_	_	_	_	_
33	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
34	B	b	ADJ	JJ	Degree=Pos	_	_	_	_
35	subunit	subunit	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
36	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1265
# text = Furthermore, the sharply reduced NF-AT activity produced by co-transfecting BKO could be "rescued" by overexpression of transfected B subunit, suggesting that depletion of this subunit was responsible for the inhibition.
1	Furthermore	furthermore	ADV	RB	_	_	_	_	SpaceAfter=No
2	,	,	PUNCT	,	_	_	_	_	_
3	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
4	sharply	sharply	NOUN	NN	Number=Sing	_	_	_	_
5	reduced	reduce	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
6	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
7	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
8	AT	AT	PROPN	NNP	Number=Sing	_	_	_	_
9	activity	activity	NOUN	NN	Number=Sing	_	_	_	_
10	produced	produce	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
11	by	by	SCONJ	IN	_	_	_	_	_
12	co-transfecting	co-transfecting	VERB	VBG	VerbForm=Ger	_	_	_	_
13	BKO	Bko	PROPN	NNP	Number=Sing	_	_	_	_
14	could	could	AUX	MD	VerbForm=Fin	_	_	_	_
15	be	be	AUX	VB	VerbForm=Inf	_	_	_	_
16	"	"	PUNCT	``	_	_	_	_	SpaceAfter=No
17	rescued	rescue	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	SpaceAfter=No
18	"	"	PUNCT	''	_	_	_	_	_
19	by	by	ADP	IN	_	_	_	_	_
20	overexpression	overexpression	NOUN	NN	Number=Sing	_	_	_	_
21	of	of	ADP	IN	_	_	_	_	_
22	transfected	transfect	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
23	B	b	NOUN	NN	Number=Sing	_	_	_	_
24	subunit	subunit	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
25	,	,	PUNCT	,	_	_	_	_	_
26	suggesting	suggest	VERB	VBG	VerbForm=Ger	_	_	_	_
27	that	that	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
28	depletion	depletion	NOUN	NN	Number=Sing	_	_	_	_
29	of	of	ADP	IN	_	_	_	_	_
30	this	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
31	subunit	subunit	NOUN	NN	Number=Sing	_	_	_	_
32	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
33	responsible	responsible	ADJ	JJ	Degree=Pos	_	_	_	_
34	for	for	ADP	IN	_	_	_	_	_
35	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
36	inhibition	inhibition	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
37	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1266
# text = These data suggest the potential utility of agents that disrupt calcineurin-mediated signal transduction pathways by blocking formation of the catalytically active dimer of calcineurin A and B subunits.
1	These	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
2	data	data	NOUN	NN	Number=Sing	_	_	_	_
3	suggest	suggest	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
4	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
5	potential	potential	ADJ	JJ	Degree=Pos	_	_	_	_
6	utility	utility	NOUN	NN	Number=Sing	_	_	_	_
7	of	of	ADP	IN	_	_	_	_	_
8	agents	agent	NOUN	NNS	Number=Plur	_	_	_	_
9	that	that	PRON	WDT	PronType=Rel	_	_	_	_
10	disrupt	disrupt	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
11	calcineurin-	calcineurin-	SYM	SYM	_	_	_	_	SpaceAfter=No
12	mediated	mediate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
13	signal	signal	NOUN	NN	Number=Sing	_	_	_	_
14	transduction	transduction	NOUN	NN	Number=Sing	_	_	_	_
15	pathways	pathway	NOUN	NNS	Number=Plur	_	_	_	_
16	by	by	SCONJ	IN	_	_	_	_	_
17	blocking	blocke	VERB	VBG	VerbForm=Ger	_	_	_	_
18	formation	formation	NOUN	NN	Number=Sing	_	_	_	_
19	of	of	ADP	IN	_	_	_	_	_
20	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
21	catalytically	catalytically	ADV	RB	_	_	_	_	_
22	active	active	ADJ	JJ	Degree=Pos	_	_	_	_
23	dimer	dimer	NOUN	NN	Number=Sing	_	_	_	_
24	of	of	ADP	IN	_	_	_	_	_
25	calcineurin	calcineurin	NOUN	NN	Number=Sing	_	_	_	_
26	A	a	NOUN	NN	Number=Sing	_	_	_	_
27	and	and	CCONJ	CC	_	_	_	_	_
28	B	b	ADJ	JJ	Degree=Pos	_	_	_	_
29	subunits	subunit	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
30	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 1267
# text = Document 003002447 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	003002447	003002447	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 1268
# text = Rel-deficient
1	Rel	Rel	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
2	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
3	deficient	deficient	NOUN	NN	Number=Sing	_	_	_	_

# sent_id = 1269
# text = T cells exhibit defects in production of interleukin 3 and granulocyte-macrophage colony-stimulating factor.
1	T	t	PROPN	NNP	Number=Sing	_	_	_	_
2	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
3	exhibit	exhibit	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
4	defects	defect	NOUN	NNS	Number=Plur	_	_	_	_
5	in	in	ADP	IN	_	_	_	_	_
6	production	production	NOUN	NN	Number=Sing	_	_	_	_
7	of	of	ADP	IN	_	_	_	_	_
8	interleukin	interleukin	NOUN	NN	Number=Sing	_	_	_	_
9	3	3	NUM	CD	NumType=Card	_	_	_	_
10	and	and	CCONJ	CC	_	_	_	_	_
11	granulocyte	granulocyte	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
12	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
13	macrophage	macrophage	NOUN	NN	Number=Sing	_	_	_	_
14	colony	colony	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
15	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
16	stimulating	stimulating	VERB	VBG	VerbForm=Ger	_	_	_	_
17	factor	factor	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
18	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 1270
# text = The c-rel protooncogene encodes a subunit of the NF-kappa B-like family of transcription factors.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	c-	c-	SYM	NFP	_	_	_	_	SpaceAfter=No
3	rel	rel	ADJ	JJ	Degree=Pos	_	_	_	_
4	protooncogene	protooncogene	NOUN	NN	Number=Sing	_	_	_	_
5	encodes	encode	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
6	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
7	subunit	subunit	NOUN	NN	Number=Sing	_	_	_	_
8	of	of	ADP	IN	_	_	_	_	_
9	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
10	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
11	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
12	kappa	kappa	PROPN	NNP	Number=Sing	_	_	_	_
13	B	b	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
14	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
15	like	like	ADJ	JJ	Degree=Pos	_	_	_	_
16	family	family	NOUN	NN	Number=Sing	_	_	_	_
17	of	of	ADP	IN	_	_	_	_	_
18	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
19	factors	factor	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
20	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1271
# text = Mice lacking
1	Mice	mouse	NOUN	NN	Number=Sing	_	_	_	_
2	lacking	lack	NOUN	NN	Number=Sing	_	_	_	_

# sent_id = 1272
# text = Rel are defective in mitogenic activation of B and T lymphocytes and display impaired humoral immunity.
1	Rel	Rel	NOUN	NN	Number=Sing	_	_	_	_
2	are	be	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
3	defective	defective	ADJ	JJ	Degree=Pos	_	_	_	_
4	in	in	ADP	IN	_	_	_	_	_
5	mitogenic	mitogenic	ADJ	JJ	Degree=Pos	_	_	_	_
6	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
7	of	of	ADP	IN	_	_	_	_	_
8	B	b	PROPN	NNP	Number=Sing	_	_	_	_
9	and	and	CCONJ	CC	_	_	_	_	_
10	T	t	PROPN	NNP	Number=Sing	_	_	_	_
11	lymphocytes	lymphocyte	NOUN	NNS	Number=Plur	_	_	_	_
12	and	and	CCONJ	CC	_	_	_	_	_
13	display	display	NOUN	NN	Number=Sing	_	_	_	_
14	impaired	impaire	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
15	humoral	humoral	ADJ	JJ	Degree=Pos	_	_	_	_
16	immunity	immunity	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
17	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1273
# text = In an attempt to identify changes in gene expression that accompany the T-cell stimulation defects associated with the loss of Rel, we have examined the expression of cell surface activation markers and cytokine production in mitogen-stimulated Rel-/- T cells.
1	In	in	ADP	IN	_	_	_	_	_
2	an	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
3	attempt	attempt	NOUN	NN	Number=Sing	_	_	_	_
4	to	to	PART	TO	_	_	_	_	_
5	identify	identify	VERB	VB	VerbForm=Inf	_	_	_	_
6	changes	change	NOUN	NNS	Number=Plur	_	_	_	_
7	in	in	ADP	IN	_	_	_	_	_
8	gene	gene	ADJ	JJ	Degree=Pos	_	_	_	_
9	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
10	that	that	PRON	WDT	PronType=Rel	_	_	_	_
11	accompany	accompany	DET	PDT	_	_	_	_	_
12	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
13	T-	t-	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
14	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
15	stimulation	stimulation	NOUN	NN	Number=Sing	_	_	_	_
16	defects	defects	NOUN	NNS	Number=Plur	_	_	_	_
17	associated	associate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
18	with	with	ADP	IN	_	_	_	_	_
19	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
20	loss	loss	NOUN	NN	Number=Sing	_	_	_	_
21	of	of	ADP	IN	_	_	_	_	_
22	Rel	Rel	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
23	,	,	PUNCT	,	_	_	_	_	_
24	we	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
25	have	have	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
26	examined	examine	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
27	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
28	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
29	of	of	ADP	IN	_	_	_	_	_
30	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
31	surface	surface	NOUN	NN	Number=Sing	_	_	_	_
32	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
33	markers	marker	NOUN	NNS	Number=Plur	_	_	_	_
34	and	and	CCONJ	CC	_	_	_	_	_
35	cytokine	cytokine	NOUN	NN	Number=Sing	_	_	_	_
36	production	production	NOUN	NN	Number=Sing	_	_	_	_
37	in	in	ADP	IN	_	_	_	_	_
38	mitogen	mitogen	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
39	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
40	stimulated	stimulate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
41	Rel	Rel	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
42	-/-	-/-	PUNCT	.	_	_	_	_	_
43	T	t	PROPN	NNP	Number=Sing	_	_	_	_
44	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
45	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1274
# text = The expression of cell surface markers including the interleukin 2 receptor alpha (IL-2R alpha) chain (CD25), CD69 and L-selectin (CD62) is normal in mitogen-activated Rel-/- T cells, but cytokine production is impaired.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
3	of	of	ADP	IN	_	_	_	_	_
4	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
5	surface	surface	NOUN	NN	Number=Sing	_	_	_	_
6	markers	marker	NOUN	NNS	Number=Plur	_	_	_	_
7	including	include	VERB	VBG	VerbForm=Ger	_	_	_	_
8	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
9	interleukin	interleukin	NOUN	NN	Number=Sing	_	_	_	_
10	2	2	NUM	CD	NumType=Card	_	_	_	_
11	receptor	receptor	NOUN	NN	Number=Sing	_	_	_	_
12	alpha	alpha	NOUN	NN	Number=Sing	_	_	_	_
13	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
14	IL	Il	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
15	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
16	2R	2r	NOUN	NN	Number=Sing	_	_	_	_
17	alpha	alpha	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
18	)	)	PUNCT	-RRB-	_	_	_	_	_
19	chain	chain	NOUN	NN	Number=Sing	_	_	_	_
20	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
21	CD25	CD25	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
22	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
23	,	,	PUNCT	,	_	_	_	_	_
24	CD69	CD69	PROPN	NNP	Number=Sing	_	_	_	_
25	and	and	CCONJ	CC	_	_	_	_	_
26	L-selectin	L-selectin	PROPN	NNP	Number=Sing	_	_	_	_
27	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
28	CD62	Cd62	X	LS	_	_	_	_	SpaceAfter=No
29	)	)	PUNCT	-RRB-	_	_	_	_	_
30	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
31	normal	normal	ADJ	JJ	Degree=Pos	_	_	_	_
32	in	in	ADP	IN	_	_	_	_	_
33	mitogen	mitogen	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
34	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
35	activated	activated	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
36	Rel	Rel	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
37	-/-	-/-	PUNCT	.	_	_	_	_	_
38	T	t	PROPN	NNP	Number=Sing	_	_	_	_
39	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
40	,	,	PUNCT	,	_	_	_	_	_
41	but	but	CCONJ	CC	_	_	_	_	_
42	cytokine	cytokine	NOUN	NN	Number=Sing	_	_	_	_
43	production	production	NOUN	NN	Number=Sing	_	_	_	_
44	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
45	impaired	impaired	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
46	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1275
# text = In Rel-/- splenic T cell cultures stimulated with phorbol 12-myristate 13-acetate and ionomycin, the levels of IL-3, IL-5, granulocyte- macrophage colony-stimulating factor (GM-CSF), tumor necrosis factor alpha (TNF-alpha), and gamma interferon (IFN-gamma) were only 2- to 3-fold lower compared with normal T cells.
1	In	in	ADP	IN	_	_	_	_	_
2	Rel	Rel	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
3	-/-	-/-	PUNCT	.	_	_	_	_	_
4	splenic	splenic	ADJ	JJ	Degree=Pos	_	_	_	_
5	T	t	NOUN	NN	Number=Sing	_	_	_	_
6	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
7	cultures	culture	NOUN	NNS	Number=Plur	_	_	_	_
8	stimulated	stimulate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
9	with	with	ADP	IN	_	_	_	_	_
10	phorbol	phorbol	NOUN	NN	Number=Sing	_	_	_	_
11	12	12	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
12	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
13	myristate	myristate	NOUN	NN	Number=Sing	_	_	_	_
14	13	13	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
15	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
16	acetate	acetate	NOUN	NN	Number=Sing	_	_	_	_
17	and	and	CCONJ	CC	_	_	_	_	_
18	ionomycin	ionomycin	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
19	,	,	PUNCT	,	_	_	_	_	_
20	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
21	levels	level	NOUN	NNS	Number=Plur	_	_	_	_
22	of	of	ADP	IN	_	_	_	_	_
23	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
24	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
25	3	3	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
26	,	,	PUNCT	,	_	_	_	_	_
27	IL	Il	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
28	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
29	5	5	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
30	,	,	PUNCT	,	_	_	_	_	_
31	granulocyte	granulocyte	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
32	-	-	PUNCT	HYPH	_	_	_	_	_
33	macrophage	macrophage	NOUN	NN	Number=Sing	_	_	_	_
34	colony	colony	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
35	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
36	stimulating	stimulating	VERB	VBG	VerbForm=Ger	_	_	_	_
37	factor	factor	NOUN	NN	Number=Sing	_	_	_	_
38	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
39	GM	GM	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
40	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
41	CSF	CSF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
42	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
43	,	,	PUNCT	,	_	_	_	_	_
44	tumor	tumor	ADP	IN	_	_	_	_	_
45	necrosis	necrosis	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
46	factor	factor	NOUN	NN	Number=Sing	_	_	_	_
47	alpha	alpha	NOUN	NN	Number=Sing	_	_	_	_
48	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
49	TNF	Tnf	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
50	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
51	alpha	alpha	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
52	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
53	,	,	PUNCT	,	_	_	_	_	_
54	and	and	CCONJ	CC	_	_	_	_	_
55	gamma	gamma	NOUN	NN	Number=Sing	_	_	_	_
56	interferon	interferon	NOUN	NN	Number=Sing	_	_	_	_
57	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
58	IFN	Ifn	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
59	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
60	gamma	gamma	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
61	)	)	PUNCT	-RRB-	_	_	_	_	_
62	were	be	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
63	only	only	ADV	RB	_	_	_	_	_
64	2	2	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
65	-	-	PUNCT	HYPH	_	_	_	_	_
66	to	to	ADP	IN	_	_	_	_	_
67	3	3	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
68	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
69	fold	fold	VERB	VB	Mood=Imp|VerbForm=Fin	_	_	_	_
70	lower	lower	ADJ	JJR	Degree=Cmp	_	_	_	_
71	compared	compare	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
72	with	with	ADP	IN	_	_	_	_	_
73	normal	normal	ADJ	JJ	Degree=Pos	_	_	_	_
74	T	t	PROPN	NNP	Number=Sing	_	_	_	_
75	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
76	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1276
# text = In contrast, anti-CD3 and anti-CD28 stimulated Rel-/- T cells, which fail to proliferate, make little or no detectable cytokines.
1	In	in	ADP	IN	_	_	_	_	_
2	contrast	contrast	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
3	,	,	PUNCT	,	_	_	_	_	_
4	anti-CD3	anti-CD3	NUM	CD	NumType=Card	_	_	_	_
5	and	and	CCONJ	CC	_	_	_	_	_
6	anti-CD28	anti-CD28	NUM	CD	NumType=Card	_	_	_	_
7	stimulated	stimulate	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
8	Rel	Rel	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
9	-/-	-/-	PUNCT	.	_	_	_	_	_
10	T	t	PROPN	NNP	Number=Sing	_	_	_	_
11	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
12	,	,	PUNCT	,	_	_	_	_	_
13	which	which	PRON	WDT	PronType=Rel	_	_	_	_
14	fail	fail	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
15	to	to	PART	TO	_	_	_	_	_
16	proliferate	proliferate	VERB	VB	VerbForm=Inf	_	_	_	SpaceAfter=No
17	,	,	PUNCT	,	_	_	_	_	_
18	make	make	VERB	VB	VerbForm=Inf	_	_	_	_
19	little	little	ADJ	JJ	Degree=Pos	_	_	_	_
20	or	or	CCONJ	CC	_	_	_	_	_
21	no	no	DET	DT	_	_	_	_	_
22	detectable	detectable	ADJ	JJ	Degree=Pos	_	_	_	_
23	cytokines	cytokine	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
24	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1277
# text = Exogenous IL-2, which restitutes the proliferative response of the anti-CD3- and anti-CD28-treated Rel-/- T cells, restores production of IL-5, TNF-alpha, and IFN-gamma, but not IL-3 and GM-CSF expression to approximately normal levels.
1	Exogenous	Exogenous	PROPN	NNP	Number=Sing	_	_	_	_
2	IL	Il	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
3	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
4	2	2	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
5	,	,	PUNCT	,	_	_	_	_	_
6	which	which	PRON	WDT	PronType=Rel	_	_	_	_
7	restitutes	restitute	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
8	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
9	proliferative	proliferative	ADJ	JJ	Degree=Pos	_	_	_	_
10	response	response	NOUN	NN	Number=Sing	_	_	_	_
11	of	of	ADP	IN	_	_	_	_	_
12	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
13	anti-CD3	anti-CD3	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
14	-	-	PUNCT	,	_	_	_	_	_
15	and	and	CCONJ	CC	_	_	_	_	_
16	anti-CD28	anti-CD28	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
17	-treated	-treated	ADJ	JJ	Degree=Pos	_	_	_	_
18	Rel	Rel	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
19	-/-	-/-	PUNCT	.	_	_	_	_	_
20	T	t	NUM	CD	NumType=Card	_	_	_	_
21	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
22	,	,	PUNCT	,	_	_	_	_	_
23	restores	restore	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
24	production	production	NOUN	NN	Number=Sing	_	_	_	_
25	of	of	ADP	IN	_	_	_	_	_
26	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
27	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
28	5	5	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
29	,	,	PUNCT	,	_	_	_	_	_
30	TNF	Tnf	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
31	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
32	alpha	alpha	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
33	,	,	PUNCT	,	_	_	_	_	_
34	and	and	CCONJ	CC	_	_	_	_	_
35	IFN	Ifn	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
36	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
37	gamma	gamma	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
38	,	,	PUNCT	,	_	_	_	_	_
39	but	but	CCONJ	CC	_	_	_	_	_
40	not	not	ADV	RB	_	_	_	_	_
41	IL	Il	ADV	RB	_	_	_	_	SpaceAfter=No
42	-	-	SYM	SYM	_	_	_	_	SpaceAfter=No
43	3	3	NUM	CD	NumType=Card	_	_	_	_
44	and	and	CCONJ	CC	_	_	_	_	_
45	GM	GM	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
46	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
47	CSF	CSF	PROPN	NNP	Number=Sing	_	_	_	_
48	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
49	to	to	PART	TO	_	_	_	_	_
50	approximately	approximately	ADV	RB	_	_	_	_	_
51	normal	normal	ADJ	JJ	Degree=Pos	_	_	_	_
52	levels	level	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
53	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1278
# text = In contrast to mitogen-activated Rel-/- T cells, lipopolysaccharide-stimulated Rel-/- macrophages produce higher than normal levels of GM-CSF.
1	In	in	ADP	IN	_	_	_	_	_
2	contrast	contrast	ADJ	JJ	Degree=Pos	_	_	_	_
3	to	to	PART	TO	_	_	_	_	_
4	mitogen	mitogen	VERB	VB	VerbForm=Inf	_	_	_	SpaceAfter=No
5	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
6	activated	activated	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
7	Rel	Rel	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
8	-/-	-/-	PUNCT	.	_	_	_	_	_
9	T	t	PROPN	NNP	Number=Sing	_	_	_	_
10	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
11	,	,	PUNCT	,	_	_	_	_	_
12	lipopolysaccharide	lipopolysaccharide	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
13	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
14	stimulated	stimulate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
15	Rel	Rel	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
16	-/-	-/-	PUNCT	.	_	_	_	_	_
17	macrophages	macrophage	NOUN	NNS	Number=Plur	_	_	_	_
18	produce	produce	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
19	higher	higher	ADJ	JJR	Degree=Cmp	_	_	_	_
20	than	than	ADP	IN	_	_	_	_	_
21	normal	normal	ADJ	JJ	Degree=Pos	_	_	_	_
22	levels	level	NOUN	NNS	Number=Plur	_	_	_	_
23	of	of	ADP	IN	_	_	_	_	_
24	GM	GM	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
25	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
26	CSF	CSF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
27	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1279
# text = These findings establish that Rel can function as an activator or repressor of gene expression and is required by T lymphocytes for production of IL-3 and GM-CSF.
1	These	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
2	findings	finding	NOUN	NNS	Number=Plur	_	_	_	_
3	establish	establish	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
4	that	that	SCONJ	IN	_	_	_	_	_
5	Rel	Rel	PROPN	NNP	Number=Sing	_	_	_	_
6	can	can	AUX	MD	VerbForm=Fin	_	_	_	_
7	function	function	VERB	VB	VerbForm=Inf	_	_	_	_
8	as	as	ADP	IN	_	_	_	_	_
9	an	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
10	activator	activator	NOUN	NN	Number=Sing	_	_	_	_
11	or	or	CCONJ	CC	_	_	_	_	_
12	repressor	repressor	NOUN	NN	Number=Sing	_	_	_	_
13	of	of	ADP	IN	_	_	_	_	_
14	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
15	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
16	and	and	CCONJ	CC	_	_	_	_	_
17	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
18	required	require	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
19	by	by	ADP	IN	_	_	_	_	_
20	T	t	PROPN	NNP	Number=Sing	_	_	_	_
21	lymphocytes	lymphocyte	NOUN	NNS	Number=Plur	_	_	_	_
22	for	for	ADP	IN	_	_	_	_	_
23	production	production	NOUN	NN	Number=Sing	_	_	_	_
24	of	of	ADP	IN	_	_	_	_	_
25	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
26	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
27	3	3	NUM	CD	NumType=Card	_	_	_	_
28	and	and	CCONJ	CC	_	_	_	_	_
29	GM	GM	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
30	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
31	CSF	CSF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
32	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 1280
# text = Document 003002451 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	003002451	003002451	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 1281
# text = Ligand-dependent repression of the erythroid transcription factor GATA-1 by the estrogen receptor.
1	Ligand	Ligand	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
2	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
3	dependent	dependent	ADJ	JJ	Degree=Pos	_	_	_	_
4	repression	repression	NOUN	NN	Number=Sing	_	_	_	_
5	of	of	ADP	IN	_	_	_	_	_
6	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
7	erythroid	erythroid	ADJ	JJ	Degree=Pos	_	_	_	_
8	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
9	factor	factor	NOUN	NN	Number=Sing	_	_	_	_
10	GATA	GATa	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
11	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
12	1	1	NUM	CD	NumType=Card	_	_	_	_
13	by	by	ADP	IN	_	_	_	_	_
14	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
15	estrogen	estrogen	ADJ	JJ	Degree=Pos	_	_	_	_
16	receptor	receptor	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
17	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 1282
# text = High-dose estrogen administration induces anemia in mammals.
1	High	high	INTJ	UH	_	_	_	_	SpaceAfter=No
2	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
3	dose	dose	VERB	VB	Mood=Imp|VerbForm=Fin	_	_	_	_
4	estrogen	estrogen	NUM	CD	NumType=Card	_	_	_	_
5	administration	administration	NOUN	NN	Number=Sing	_	_	_	_
6	induces	induce	NOUN	NNS	Number=Plur	_	_	_	_
7	anemia	anemion	NOUN	NN	Number=Sing	_	_	_	_
8	in	in	ADP	IN	_	_	_	_	_
9	mammals	mammal	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
10	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1283
# text = In chickens, estrogens stimulate outgrowth of bone marrow-derived erythroid progenitor cells and delay their maturation.
1	In	in	ADP	IN	_	_	_	_	_
2	chickens	chicken	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
3	,	,	PUNCT	,	_	_	_	_	_
4	estrogens	estrogen	NOUN	NNS	Number=Plur	_	_	_	_
5	stimulate	stimulate	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
6	outgrowth	outgrowth	ADP	IN	_	_	_	_	_
7	of	of	ADP	IN	_	_	_	_	_
8	bone	bone	NOUN	NN	Number=Sing	_	_	_	_
9	marrow	marrow	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
10	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
11	derived	derive	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
12	erythroid	erythroid	ADJ	JJ	Degree=Pos	_	_	_	_
13	progenitor	progenitor	NOUN	NN	Number=Sing	_	_	_	_
14	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
15	and	and	CCONJ	CC	_	_	_	_	_
16	delay	delay	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
17	their	they	PRON	PRP$	Number=Plur|Person=3|Poss=Yes|PronType=Prs	_	_	_	_
18	maturation	maturation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
19	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1284
# text = This delay is associated with down-regulation of many erythroid cell-specific genes, including alpha- and beta-globin, band 3, band 4.1, and the erythroid cell-specific histone
1	This	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
2	delay	delay	NOUN	NN	Number=Sing	_	_	_	_
3	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
4	associated	associate	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
5	with	with	ADP	IN	_	_	_	_	_
6	down	down	ADV	RB	_	_	_	_	SpaceAfter=No
7	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
8	regulation	regulation	NOUN	NN	Number=Sing	_	_	_	_
9	of	of	ADP	IN	_	_	_	_	_
10	many	many	ADJ	JJ	Degree=Pos	_	_	_	_
11	erythroid	erythroid	ADJ	JJ	Degree=Pos	_	_	_	_
12	cell	cell	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
13	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
14	specific	specific	ADJ	JJ	Degree=Pos	_	_	_	_
15	genes	gene	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
16	,	,	PUNCT	,	_	_	_	_	_
17	including	include	VERB	VBG	VerbForm=Ger	_	_	_	_
18	alpha	alpha	ADV	RB	_	_	_	_	SpaceAfter=No
19	-	-	PUNCT	,	_	_	_	_	_
20	and	and	CCONJ	CC	_	_	_	_	_
21	beta	beta	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
22	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
23	globin	globin	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
24	,	,	PUNCT	,	_	_	_	_	_
25	band	band	NOUN	NN	Number=Sing	_	_	_	_
26	3	3	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
27	,	,	PUNCT	,	_	_	_	_	_
28	band	band	NOUN	NN	Number=Sing	_	_	_	_
29	4.1	4.1	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
30	,	,	PUNCT	,	_	_	_	_	_
31	and	and	CCONJ	CC	_	_	_	_	_
32	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
33	erythroid	erythroid	ADJ	JJ	Degree=Pos	_	_	_	_
34	cell	cell	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
35	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
36	specific	specific	ADJ	JJ	Degree=Pos	_	_	_	_
37	histone	histone	NOUN	NN	Number=Sing	_	_	_	_

# sent_id = 1285
# text = H5.
1	H5	h5	X	LS	_	_	_	_	SpaceAfter=No
2	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1286
# text = We show here that estrogens also reduce the number of erythroid progenitor cells in primary human bone marrow cultures.
1	We	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
2	show	show	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
3	here	here	ADV	RB	PronType=Dem	_	_	_	_
4	that	that	SCONJ	IN	_	_	_	_	_
5	estrogens	estrogen	NOUN	NNS	Number=Plur	_	_	_	_
6	also	also	ADV	RB	_	_	_	_	_
7	reduce	reduce	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
8	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
9	number	number	NOUN	NN	Number=Sing	_	_	_	_
10	of	of	ADP	IN	_	_	_	_	_
11	erythroid	erythroid	ADJ	JJ	Degree=Pos	_	_	_	_
12	progenitor	progenitor	NOUN	NN	Number=Sing	_	_	_	_
13	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
14	in	in	ADP	IN	_	_	_	_	_
15	primary	primary	ADJ	JJ	Degree=Pos	_	_	_	_
16	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
17	bone	bone	NOUN	NN	Number=Sing	_	_	_	_
18	marrow	marrow	NOUN	NN	Number=Sing	_	_	_	_
19	cultures	culture	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
20	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1287
# text = To address potential mechanisms by which estrogens suppress erythropoiesis, we have examined their effects on GATA-1, an erythroid transcription factor that participates in the regulation of the majority of erythroid cell-specific genes and is necessary for full maturation of erythrocytes.
1	To	to	PART	TO	_	_	_	_	_
2	address	address	VERB	VB	VerbForm=Inf	_	_	_	_
3	potential	potential	ADJ	JJ	Degree=Pos	_	_	_	_
4	mechanisms	mechanism	NOUN	NNS	Number=Plur	_	_	_	_
5	by	by	ADP	IN	_	_	_	_	_
6	which	which	PRON	WDT	PronType=Rel	_	_	_	_
7	estrogens	estrogen	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
8	suppress	suppress	NOUN	NN	Number=Sing	_	_	_	_
9	erythropoiesis	erythropoiesis	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	SpaceAfter=No
10	,	,	PUNCT	,	_	_	_	_	_
11	we	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
12	have	have	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
13	examined	examine	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
14	their	they	PRON	PRP$	Number=Plur|Person=3|Poss=Yes|PronType=Prs	_	_	_	_
15	effects	effect	NOUN	NNS	Number=Plur	_	_	_	_
16	on	on	ADP	IN	_	_	_	_	_
17	GATA	GATA	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
18	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
19	1	1	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
20	,	,	PUNCT	,	_	_	_	_	_
21	an	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
22	erythroid	erythroid	ADJ	JJ	Degree=Pos	_	_	_	_
23	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
24	factor	factor	NOUN	NN	Number=Sing	_	_	_	_
25	that	that	PRON	WDT	PronType=Rel	_	_	_	_
26	participates	participate	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
27	in	in	ADP	IN	_	_	_	_	_
28	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
29	regulation	regulation	NOUN	NN	Number=Sing	_	_	_	_
30	of	of	ADP	IN	_	_	_	_	_
31	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
32	majority	majority	NOUN	NN	Number=Sing	_	_	_	_
33	of	of	ADP	IN	_	_	_	_	_
34	erythroid	erythroid	ADJ	JJ	Degree=Pos	_	_	_	_
35	cell	cell	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
36	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
37	specific	specific	ADJ	JJ	Degree=Pos	_	_	_	_
38	genes	gene	NOUN	NNS	Number=Plur	_	_	_	_
39	and	and	CCONJ	CC	_	_	_	_	_
40	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
41	necessary	necessary	ADJ	JJ	Degree=Pos	_	_	_	_
42	for	for	ADP	IN	_	_	_	_	_
43	full	full	ADJ	JJ	Degree=Pos	_	_	_	_
44	maturation	maturation	NOUN	NN	Number=Sing	_	_	_	_
45	of	of	ADP	IN	_	_	_	_	_
46	erythrocytes	erythrocyte	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
47	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1288
# text = We demonstrate that the transcriptional activity of GATA-1 is strongly repressed by the estrogen receptor (ER) in a ligand-dependent manner and that this repression is reversible in the presence of 4-hydroxytamoxifen.
1	We	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
2	demonstrate	demonstrate	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
3	that	that	SCONJ	IN	_	_	_	_	_
4	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
5	transcriptional	transcriptional	ADJ	JJ	Degree=Pos	_	_	_	_
6	activity	activity	NOUN	NN	Number=Sing	_	_	_	_
7	of	of	ADP	IN	_	_	_	_	_
8	GATA	GATA	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
9	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
10	1	1	NUM	CD	NumType=Card	_	_	_	_
11	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
12	strongly	strongly	ADV	RB	_	_	_	_	_
13	repressed	repress	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
14	by	by	ADP	IN	_	_	_	_	_
15	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
16	estrogen	estrogen	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
17	receptor	receptor	NOUN	NN	Number=Sing	_	_	_	_
18	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
19	ER	er	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
20	)	)	PUNCT	-RRB-	_	_	_	_	_
21	in	in	ADP	IN	_	_	_	_	_
22	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
23	ligand	ligand	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
24	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
25	dependent	dependent	ADJ	JJ	Degree=Pos	_	_	_	_
26	manner	manner	NOUN	NN	Number=Sing	_	_	_	_
27	and	and	CCONJ	CC	_	_	_	_	_
28	that	that	SCONJ	IN	_	_	_	_	_
29	this	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
30	repression	repression	NOUN	NN	Number=Sing	_	_	_	_
31	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
32	reversible	reversible	ADJ	JJ	Degree=Pos	_	_	_	_
33	in	in	ADP	IN	_	_	_	_	_
34	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
35	presence	presence	NOUN	NN	Number=Sing	_	_	_	_
36	of	of	ADP	IN	_	_	_	_	_
37	4	4	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
38	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
39	hydroxytamoxifen	hydroxytamoxifen	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
40	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1289
# text = ER-mediated repression of GATA-1 activity occurs on an artificial promoter containing a single GATA-binding site, as well as in the context of an intact promoter which is normally regulated by GATA-1.
1	ER-	ER-	SYM	NFP	_	_	_	_	SpaceAfter=No
2	mediated	mediate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
3	repression	repression	NOUN	NN	Number=Sing	_	_	_	_
4	of	of	ADP	IN	_	_	_	_	_
5	GATA	GATA	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
6	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
7	1	1	NUM	CD	NumType=Card	_	_	_	_
8	activity	activity	NOUN	NN	Number=Sing	_	_	_	_
9	occurs	occur	NOUN	NNS	Number=Plur	_	_	_	_
10	on	on	ADP	IN	_	_	_	_	_
11	an	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
12	artificial	artificial	ADJ	JJ	Degree=Pos	_	_	_	_
13	promoter	promoter	NOUN	NN	Number=Sing	_	_	_	_
14	containing	contain	VERB	VBG	VerbForm=Ger	_	_	_	_
15	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
16	single	single	ADJ	JJ	Degree=Pos	_	_	_	_
17	GATA	GATa	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
18	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
19	binding	binding	VERB	VBG	VerbForm=Ger	_	_	_	_
20	site	site	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
21	,	,	PUNCT	,	_	_	_	_	_
22	as	as	ADV	RB	_	_	_	_	_
23	well	well	ADV	RB	Degree=Pos	_	_	_	_
24	as	as	ADP	IN	_	_	_	_	_
25	in	in	ADP	IN	_	_	_	_	_
26	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
27	context	context	NOUN	NN	Number=Sing	_	_	_	_
28	of	of	ADP	IN	_	_	_	_	_
29	an	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
30	intact	intact	ADJ	JJ	Degree=Pos	_	_	_	_
31	promoter	promoter	NOUN	NN	Number=Sing	_	_	_	_
32	which	which	PRON	WDT	PronType=Rel	_	_	_	_
33	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
34	normally	normally	ADV	RB	_	_	_	_	_
35	regulated	regulate	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
36	by	by	ADP	IN	_	_	_	_	_
37	GATA	GATA	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
38	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
39	1	1	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
40	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1290
# text = GATA-1 and ER bind to each other in vitro in the absence of DNA.
1	GATA	GATa	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
2	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
3	1	1	NUM	CD	NumType=Card	_	_	_	_
4	and	and	CCONJ	CC	_	_	_	_	_
5	ER	er	NOUN	NN	Number=Sing	_	_	_	_
6	bind	bind	NOUN	NN	Number=Sing	_	_	_	_
7	to	to	ADP	IN	_	_	_	_	_
8	each	each	DET	DT	_	_	_	_	_
9	other	other	ADJ	JJ	Degree=Pos	_	_	_	_
10	in	in	ADP	IN	_	_	_	_	_
11	vitro	vitro	NUM	CD	NumType=Card	_	_	_	_
12	in	in	ADP	IN	_	_	_	_	_
13	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
14	absence	absence	NOUN	NN	Number=Sing	_	_	_	_
15	of	of	ADP	IN	_	_	_	_	_
16	DNA	dna	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
17	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1291
# text = In coimmunoprecipitation experiments using transfected COS cells, GATA-1 and ER associate in a ligand-dependent manner.
1	In	in	ADP	IN	_	_	_	_	_
2	coimmunoprecipitation	coimmunoprecipitation	NOUN	NN	Number=Sing	_	_	_	_
3	experiments	experiment	NOUN	NNS	Number=Plur	_	_	_	_
4	using	use	VERB	VBG	VerbForm=Ger	_	_	_	_
5	transfected	transfect	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
6	COS	Cos	NOUN	NNS	Number=Plur	_	_	_	_
7	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
8	,	,	PUNCT	,	_	_	_	_	_
9	GATA	GATA	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
10	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
11	1	1	NUM	CD	NumType=Card	_	_	_	_
12	and	and	CCONJ	CC	_	_	_	_	_
13	ER	er	NOUN	NN	Number=Sing	_	_	_	_
14	associate	associate	NOUN	NN	Number=Sing	_	_	_	_
15	in	in	ADP	IN	_	_	_	_	_
16	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
17	ligand	ligand	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
18	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
19	dependent	dependent	ADJ	JJ	Degree=Pos	_	_	_	_
20	manner	manner	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
21	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1292
# text = Mapping experiments indicate that GATA-1 and the ER form at least two contacts, which involve the finger region and the N-terminal activation domain of GATA-1.
1	Mapping	mapping	NOUN	NN	Number=Sing	_	_	_	_
2	experiments	experiment	NOUN	NNS	Number=Plur	_	_	_	_
3	indicate	indicate	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
4	that	that	SCONJ	IN	_	_	_	_	_
5	GATA	GATA	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
6	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
7	1	1	NUM	CD	NumType=Card	_	_	_	_
8	and	and	CCONJ	CC	_	_	_	_	_
9	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
10	ER	er	NOUN	NN	Number=Sing	_	_	_	_
11	form	form	NOUN	NN	Number=Sing	_	_	_	_
12	at	at	ADV	RB	_	_	_	_	_
13	least	least	ADV	RBS	Degree=Sup	_	_	_	_
14	two	two	NUM	CD	NumType=Card	_	_	_	_
15	contacts	contact	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
16	,	,	PUNCT	,	_	_	_	_	_
17	which	which	PRON	WDT	PronType=Rel	_	_	_	_
18	involve	involve	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
19	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
20	finger	finger	NOUN	NN	Number=Sing	_	_	_	_
21	region	region	NOUN	NN	Number=Sing	_	_	_	_
22	and	and	CCONJ	CC	_	_	_	_	_
23	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
24	N-	n-	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
25	terminal	terminal	NOUN	NN	Number=Sing	_	_	_	_
26	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
27	domain	domain	NOUN	NN	Number=Sing	_	_	_	_
28	of	of	ADP	IN	_	_	_	_	_
29	GATA	GATA	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
30	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
31	1	1	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
32	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1293
# text = We speculate that estrogens exert effects on erythropoiesis by modulating GATA-1 activity through protein-protein interaction with the ER. (ABSTRACT TRUNCATED AT 250 WORDS)
1	We	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
2	speculate	speculate	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
3	that	that	SCONJ	IN	_	_	_	_	_
4	estrogens	estrogen	NOUN	NNS	Number=Plur	_	_	_	_
5	exert	exert	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
6	effects	effect	NOUN	NNS	Number=Plur	_	_	_	_
7	on	on	ADP	IN	_	_	_	_	_
8	erythropoiesis	erythropoiesis	NOUN	NN	Number=Sing	_	_	_	_
9	by	by	SCONJ	IN	_	_	_	_	_
10	modulating	modulat	VERB	VBG	VerbForm=Ger	_	_	_	_
11	GATA	GATA	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
12	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
13	1	1	NUM	CD	NumType=Card	_	_	_	_
14	activity	activity	NOUN	NN	Number=Sing	_	_	_	_
15	through	through	ADP	IN	_	_	_	_	_
16	protein-	protein-	SYM	NFP	_	_	_	_	SpaceAfter=No
17	protein	protein	NOUN	NN	Number=Sing	_	_	_	_
18	interaction	interaction	NOUN	NN	Number=Sing	_	_	_	_
19	with	with	ADP	IN	_	_	_	_	_
20	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
21	ER	er	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
22	.	.	PUNCT	.	_	_	_	_	_
23	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
24	ABSTRACT	Abstract	ADV	RB	_	_	_	_	_
25	TRUNCATED	tRUNCATEd	VERB	VB	Mood=Imp|VerbForm=Fin	_	_	_	_
26	AT	at	ADV	RB	_	_	_	_	_
27	250	250	NUM	CD	NumType=Card	_	_	_	_
28	WORDS	words	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
29	)	)	PUNCT	-RRB-	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 1294
# text = Document 003002452 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	003002452	003002452	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 1295
# text = Anti-CD2 receptor antibodies activate the HIV long terminal repeat in T lymphocytes.
1	Anti-CD2	Anti-CD2	NUM	CD	NumType=Card	_	_	_	_
2	receptor	receptor	NOUN	NN	Number=Sing	_	_	_	_
3	antibodies	antibody	NOUN	NNS	Number=Plur	_	_	_	_
4	activate	activate	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
5	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
6	HIV	HIV	PROPN	NNP	Number=Sing	_	_	_	_
7	long	long	ADJ	JJ	Degree=Pos	_	_	_	_
8	terminal	terminal	ADJ	JJ	Degree=Pos	_	_	_	_
9	repeat	repeat	NOUN	NN	Number=Sing	_	_	_	_
10	in	in	ADP	IN	_	_	_	_	_
11	T	t	PROPN	NNP	Number=Sing	_	_	_	_
12	lymphocytes	lymphocyte	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
13	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 1296
# text = The CD2 T lymphocyte glycoprotein surface molecule mediates both cell to cell adhesion and T cell activation, two processes that are involved in the spread of HIV infection.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	CD2	CD2	NUM	CD	NumType=Card	_	_	_	_
3	T	t	NUM	CD	NumType=Card	_	_	_	_
4	lymphocyte	lymphocyte	NOUN	NN	Number=Sing	_	_	_	_
5	glycoprotein	glycoprotein	NOUN	NN	Number=Sing	_	_	_	_
6	surface	surface	NOUN	NN	Number=Sing	_	_	_	_
7	molecule	molecule	NOUN	NN	Number=Sing	_	_	_	_
8	mediates	mediate	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
9	both	both	DET	DT	_	_	_	_	_
10	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
11	to	to	PART	TO	_	_	_	_	_
12	cell	cell	VERB	VB	VerbForm=Inf	_	_	_	_
13	adhesion	adhesion	NOUN	NN	Number=Sing	_	_	_	_
14	and	and	CCONJ	CC	_	_	_	_	_
15	T	t	NOUN	NN	Number=Sing	_	_	_	_
16	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
17	activation	activation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
18	,	,	PUNCT	,	_	_	_	_	_
19	two	two	NUM	CD	NumType=Card	_	_	_	_
20	processes	process	NOUN	NNS	Number=Plur	_	_	_	_
21	that	that	PRON	WDT	PronType=Rel	_	_	_	_
22	are	be	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
23	involved	involved	ADJ	JJ	Degree=Pos	_	_	_	_
24	in	in	ADP	IN	_	_	_	_	_
25	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
26	spread	spread	NOUN	NN	Number=Sing	_	_	_	_
27	of	of	ADP	IN	_	_	_	_	_
28	HIV	Hiv	NOUN	NN	Number=Sing	_	_	_	_
29	infection	infection	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
30	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1297
# text = Treatment of chronically HIV-infected PBMC with anti-CD2 mAb has been shown to induce the expression of infectious virus from these cultures.
1	Treatment	treatment	NOUN	NN	Number=Sing	_	_	_	_
2	of	of	ADP	IN	_	_	_	_	_
3	chronically	chronically	ADV	RB	_	_	_	_	_
4	HIV-	HIV-	PUNCT	:	_	_	_	_	SpaceAfter=No
5	infected	infect	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
6	PBMC	Pbmc	NOUN	NN	Number=Sing	_	_	_	_
7	with	with	ADP	IN	_	_	_	_	_
8	anti-CD2	anti-CD2	NUM	CD	NumType=Card	_	_	_	_
9	mAb	mAb	PROPN	NNP	Number=Sing	_	_	_	_
10	has	have	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
11	been	be	AUX	VBN	Tense=Past|VerbForm=Part	_	_	_	_
12	shown	show	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
13	to	to	PART	TO	_	_	_	_	_
14	induce	induce	VERB	VB	VerbForm=Inf	_	_	_	_
15	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
16	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
17	of	of	ADP	IN	_	_	_	_	_
18	infectious	infectious	ADJ	JJ	Degree=Pos	_	_	_	_
19	virus	virus	NOUN	NN	Number=Sing	_	_	_	_
20	from	from	ADP	IN	_	_	_	_	_
21	these	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
22	cultures	culture	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
23	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1298
# text = In this study we investigated the mechanisms whereby anti-CD2 antibodies stimulate viral production.
1	In	in	ADP	IN	_	_	_	_	_
2	this	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
3	study	study	NOUN	NN	Number=Sing	_	_	_	_
4	we	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
5	investigated	investigate	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
6	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
7	mechanisms	mechanism	NOUN	NNS	Number=Plur	_	_	_	_
8	whereby	whereby	ADV	RP	_	_	_	_	_
9	anti-CD2	anti-CD2	NUM	CD	NumType=Card	_	_	_	_
10	antibodies	antibody	NOUN	NNS	Number=Plur	_	_	_	_
11	stimulate	stimulate	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
12	viral	viral	ADJ	JJ	Degree=Pos	_	_	_	_
13	production	production	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
14	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1299
# text = We demonstrate that treatment of transiently transfected T lymphocytes with anti-CD2 antibodies results in activation of the HIV long terminal repeat.
1	We	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
2	demonstrate	demonstrate	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
3	that	that	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
4	treatment	treatment	NOUN	NN	Number=Sing	_	_	_	_
5	of	of	ADP	IN	_	_	_	_	_
6	transiently	transiently	ADV	RB	_	_	_	_	_
7	transfected	transfect	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
8	T	t	PROPN	NNP	Number=Sing	_	_	_	_
9	lymphocytes	lymphocyte	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
10	with	with	ADP	IN	_	_	_	_	_
11	anti-CD2	anti-CD2	NUM	CD	NumType=Card	_	_	_	_
12	antibodies	antibody	NOUN	NNS	Number=Plur	_	_	_	_
13	results	result	NOUN	NNS	Number=Plur	_	_	_	_
14	in	in	ADP	IN	_	_	_	_	_
15	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
16	of	of	ADP	IN	_	_	_	_	_
17	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
18	HIV	HIV	PROPN	NNP	Number=Sing	_	_	_	_
19	long	long	ADJ	JJ	Degree=Pos	_	_	_	_
20	terminal	terminal	ADJ	JJ	Degree=Pos	_	_	_	_
21	repeat	repeat	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
22	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1300
# text = Furthermore, CAT assays using mutated HIV long terminal repeat-CAT constructs and gel shift assays demonstrate that this activation is dependent on the NF-kappa B enhancer.
1	Furthermore	furthermore	ADV	RB	_	_	_	_	SpaceAfter=No
2	,	,	PUNCT	,	_	_	_	_	_
3	CAT	cat	PROPN	NNP	Number=Sing	_	_	_	_
4	assays	assay	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
5	using	use	VERB	VBG	VerbForm=Ger	_	_	_	_
6	mutated	mutate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
7	HIV	HIV	PROPN	NNP	Number=Sing	_	_	_	_
8	long	long	ADJ	JJ	Degree=Pos	_	_	_	_
9	terminal	terminal	ADJ	JJ	Degree=Pos	_	_	_	_
10	repeat	repeat	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
11	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
12	CAT	cat	NOUN	NN	Number=Sing	_	_	_	_
13	constructs	constructs	NOUN	NNS	Number=Plur	_	_	_	_
14	and	and	CCONJ	CC	_	_	_	_	_
15	gel	gel	NOUN	NN	Number=Sing	_	_	_	_
16	shift	shift	NOUN	NN	Number=Sing	_	_	_	_
17	assays	assay	NOUN	NNS	Number=Plur	_	_	_	_
18	demonstrate	demonstrate	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
19	that	that	SCONJ	IN	_	_	_	_	_
20	this	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
21	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
22	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
23	dependent	dependent	ADJ	JJ	Degree=Pos	_	_	_	_
24	on	on	ADP	IN	_	_	_	_	_
25	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
26	NF	Nf	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
27	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
28	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_
29	B	b	NOUN	NN	Number=Sing	_	_	_	_
30	enhancer	enhancer	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
31	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1301
# text = These studies suggest that interaction of CD2 with its natural ligand, LFA-3, may play a role in regulation of HIV expression.
1	These	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
2	studies	study	NOUN	NNS	Number=Plur	_	_	_	_
3	suggest	suggest	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
4	that	that	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
5	interaction	interaction	NOUN	NN	Number=Sing	_	_	_	_
6	of	of	ADP	IN	_	_	_	_	_
7	CD2	Cd2	NOUN	NN	Number=Sing	_	_	_	_
8	with	with	ADP	IN	_	_	_	_	_
9	its	its	PRON	PRP$	Gender=Neut|Number=Sing|Person=3|Poss=Yes|PronType=Prs	_	_	_	_
10	natural	natural	ADJ	JJ	Degree=Pos	_	_	_	_
11	ligand	ligand	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
12	,	,	PUNCT	,	_	_	_	_	_
13	LFA	LFA	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
14	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
15	3	3	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
16	,	,	PUNCT	,	_	_	_	_	_
17	may	may	AUX	MD	VerbForm=Fin	_	_	_	_
18	play	play	VERB	VB	VerbForm=Inf	_	_	_	_
19	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
20	role	role	NOUN	NN	Number=Sing	_	_	_	_
21	in	in	ADP	IN	_	_	_	_	_
22	regulation	regulation	NOUN	NN	Number=Sing	_	_	_	_
23	of	of	ADP	IN	_	_	_	_	_
24	HIV	HIV	PROPN	NNP	Number=Sing	_	_	_	_
25	expression	expression	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
26	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 1302
# text = Document 003002459 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	003002459	003002459	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 1303
# text = Defective translocation of protein kinase C in multidrug-resistant HL-60 cells confers a reversible loss of phorbol ester-induced monocytic differentiation.
1	Defective	defective	ADJ	JJ	Degree=Pos	_	_	_	_
2	translocation	translocation	NOUN	NN	Number=Sing	_	_	_	_
3	of	of	ADP	IN	_	_	_	_	_
4	protein	protein	NOUN	NN	Number=Sing	_	_	_	_
5	kinase	kinase	NOUN	NN	Number=Sing	_	_	_	_
6	C	c	NOUN	NN	Number=Sing	_	_	_	_
7	in	in	ADP	IN	_	_	_	_	_
8	multidrug	multidrug	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
9	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
10	resistant	resistant	NOUN	NN	Number=Sing	_	_	_	_
11	HL	Hl	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
12	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
13	60	60	NUM	CD	NumType=Card	_	_	_	_
14	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
15	confers	confer	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
16	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
17	reversible	reversible	ADJ	JJ	Degree=Pos	_	_	_	_
18	loss	loss	NOUN	NN	Number=Sing	_	_	_	_
19	of	of	ADP	IN	_	_	_	_	_
20	phorbol	phorbol	NOUN	NN	Number=Sing	_	_	_	_
21	ester	ester	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
22	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
23	induced	induce	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
24	monocytic	monocytic	ADJ	JJ	Degree=Pos	_	_	_	_
25	differentiation	differentiation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
26	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 1304
# text = Previous studies have demonstrated that human HL-60 myeloid leukemia cells differentiate in response to phorbol esters.
1	Previous	previous	ADJ	JJ	Degree=Pos	_	_	_	_
2	studies	study	NOUN	NNS	Number=Plur	_	_	_	_
3	have	have	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
4	demonstrated	demonstrate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
5	that	that	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
6	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
7	HL	Hl	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
8	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
9	60	60	NUM	CD	NumType=Card	_	_	_	_
10	myeloid	myeloid	ADJ	JJ	Degree=Pos	_	_	_	_
11	leukemia	leukemia	NOUN	NN	Number=Sing	_	_	_	_
12	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
13	differentiate	differentiate	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
14	in	in	ADP	IN	_	_	_	_	_
15	response	response	NOUN	NN	Number=Sing	_	_	_	_
16	to	to	PART	TO	_	_	_	_	_
17	phorbol	phorbol	VERB	VB	VerbForm=Inf	_	_	_	_
18	esters	ester	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
19	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1305
# text = This event is associated with induction of the c-jun early response gene and appearance of a monocytic phenotype.
1	This	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
2	event	event	NOUN	NN	Number=Sing	_	_	_	_
3	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
4	associated	associate	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
5	with	with	ADP	IN	_	_	_	_	_
6	induction	induction	NOUN	NN	Number=Sing	_	_	_	_
7	of	of	ADP	IN	_	_	_	_	_
8	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
9	c-	c-	SYM	SYM	_	_	_	_	SpaceAfter=No
10	jun	jun	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
11	early	early	ADJ	JJ	Degree=Pos	_	_	_	_
12	response	response	NOUN	NN	Number=Sing	_	_	_	_
13	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
14	and	and	CCONJ	CC	_	_	_	_	_
15	appearance	appearance	NOUN	NN	Number=Sing	_	_	_	_
16	of	of	ADP	IN	_	_	_	_	_
17	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
18	monocytic	monocytic	ADJ	JJ	Degree=Pos	_	_	_	_
19	phenotype	phenotype	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
20	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1306
# text = The present studies have examined the effects of vincristine-selected, multidrug resistance on 12-O-tetradecanoylphorbol-13-acetate (TPA)-induced HL-60 cell differentiation.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	present	present	ADJ	JJ	Degree=Pos	_	_	_	_
3	studies	study	NOUN	NNS	Number=Plur	_	_	_	_
4	have	have	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
5	examined	examine	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
6	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
7	effects	effect	NOUN	NNS	Number=Plur	_	_	_	_
8	of	of	ADP	IN	_	_	_	_	_
9	vincristine	vincristine	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
10	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
11	selected	select	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	SpaceAfter=No
12	,	,	PUNCT	,	_	_	_	_	_
13	multidrug	multidrug	VERB	VBG	VerbForm=Ger	_	_	_	_
14	resistance	resistance	NOUN	NN	Number=Sing	_	_	_	_
15	on	on	ADP	IN	_	_	_	_	_
16	12	12	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
17	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
18	O	of	INTJ	UH	_	_	_	_	SpaceAfter=No
19	-tetradecanoylphorbol	-tetradecanoylphorbol	INTJ	UH	_	_	_	_	SpaceAfter=No
20	-13	-13	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
21	-acetate	-acetate	NOUN	NN	Number=Sing	_	_	_	_
22	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
23	TPA	TPA	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
24	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
25	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
26	induced	induce	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
27	HL	Hl	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
28	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
29	60	60	NUM	CD	NumType=Card	_	_	_	_
30	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
31	differentiation	differentiation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
32	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1307
# text = The results demonstrate that multidrug-resistant HL-60 cells, designated HL-60/vinc, fail to respond to TPA with an increase in c-jun transcripts or other phenotypic characteristics of monocytic differentiation.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	results	result	NOUN	NNS	Number=Plur	_	_	_	_
3	demonstrate	demonstrate	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
4	that	that	SCONJ	IN	_	_	_	_	_
5	multidrug	multidrug	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
6	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
7	resistant	resistant	NOUN	NN	Number=Sing	_	_	_	_
8	HL	Hl	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
9	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
10	60	60	NUM	CD	NumType=Card	_	_	_	_
11	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
12	,	,	PUNCT	,	_	_	_	_	_
13	designated	designate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
14	HL	HL	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
15	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
16	60	60	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
17	/	/	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
18	vinc	vinc	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
19	,	,	PUNCT	,	_	_	_	_	_
20	fail	fail	NOUN	NN	Number=Sing	_	_	_	_
21	to	to	PART	TO	_	_	_	_	_
22	respond	respond	VERB	VB	VerbForm=Inf	_	_	_	_
23	to	to	ADP	IN	_	_	_	_	_
24	TPA	TPA	PROPN	NNP	Number=Sing	_	_	_	_
25	with	with	ADP	IN	_	_	_	_	_
26	an	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
27	increase	increase	NOUN	NN	Number=Sing	_	_	_	_
28	in	in	ADP	IN	_	_	_	_	_
29	c-	c-	SYM	NFP	_	_	_	_	SpaceAfter=No
30	jun	jun	NOUN	NN	Number=Sing	_	_	_	_
31	transcripts	transcript	NOUN	NNS	Number=Plur	_	_	_	_
32	or	or	CCONJ	CC	_	_	_	_	_
33	other	other	ADJ	JJ	Degree=Pos	_	_	_	_
34	phenotypic	phenotypic	ADJ	JJ	Degree=Pos	_	_	_	_
35	characteristics	characteristic	NOUN	NNS	Number=Plur	_	_	_	_
36	of	of	ADP	IN	_	_	_	_	_
37	monocytic	monocytic	ADJ	JJ	Degree=Pos	_	_	_	_
38	differentiation	differentiation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
39	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1308
# text = By contrast, treatment of HL-60/vinc cells with okadaic acid, an inhibitor of serine/threonine protein phosphatases, induces c-jun transcription, growth arrest, and expression of the c-fms gene.
1	By	by	ADP	IN	_	_	_	_	_
2	contrast	contrast	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
3	,	,	PUNCT	,	_	_	_	_	_
4	treatment	treatment	NOUN	NN	Number=Sing	_	_	_	_
5	of	of	ADP	IN	_	_	_	_	_
6	HL	HL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
7	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
8	60	60	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
9	/	/	PUNCT	,	_	_	_	_	SpaceAfter=No
10	vinc	vinc	NOUN	NN	Number=Sing	_	_	_	_
11	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
12	with	with	ADP	IN	_	_	_	_	_
13	okadaic	okadaic	ADJ	JJ	Degree=Pos	_	_	_	_
14	acid	acid	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
15	,	,	PUNCT	,	_	_	_	_	_
16	an	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
17	inhibitor	inhibitor	NOUN	NN	Number=Sing	_	_	_	_
18	of	of	ADP	IN	_	_	_	_	_
19	serine	serine	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
20	/	/	PUNCT	,	_	_	_	_	SpaceAfter=No
21	threonine	threonine	NUM	CD	NumType=Card	_	_	_	_
22	protein	protein	NOUN	NN	Number=Sing	_	_	_	_
23	phosphatases	phosphatase	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
24	,	,	PUNCT	,	_	_	_	_	_
25	induces	induce	NOUN	NNS	Number=Plur	_	_	_	_
26	c-	c-	PUNCT	:	_	_	_	_	SpaceAfter=No
27	jun	jun	NOUN	NN	Number=Sing	_	_	_	_
28	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
29	,	,	PUNCT	,	_	_	_	_	_
30	growth	growth	NOUN	NN	Number=Sing	_	_	_	_
31	arrest	arrest	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
32	,	,	PUNCT	,	_	_	_	_	_
33	and	and	CCONJ	CC	_	_	_	_	_
34	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
35	of	of	ADP	IN	_	_	_	_	_
36	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
37	c-	c-	SYM	NFP	_	_	_	_	SpaceAfter=No
38	fms	fm	NOUN	NNS	Number=Plur	_	_	_	_
39	gene	gene	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
40	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1309
# text = Studies were also performed with an HL-60/vinc revertant (HL-60/vinc/R) line that has regained partial sensitivity to vincristine.
1	Studies	study	NOUN	NNS	Number=Plur	_	_	_	_
2	were	be	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
3	also	also	ADV	RB	_	_	_	_	_
4	performed	perform	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
5	with	with	ADP	IN	_	_	_	_	_
6	an	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
7	HL	HL	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
8	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
9	60	60	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
10	/	/	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
11	vinc	vinc	NOUN	NN	Number=Sing	_	_	_	_
12	revertant	revertant	NOUN	NN	Number=Sing	_	_	_	_
13	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
14	HL-	HL-	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
15	60	60	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
16	/	/	PUNCT	,	_	_	_	_	SpaceAfter=No
17	vinc/R	vinc/R	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
18	)	)	PUNCT	-RRB-	_	_	_	_	_
19	line	line	NOUN	NN	Number=Sing	_	_	_	_
20	that	that	PRON	WDT	PronType=Rel	_	_	_	_
21	has	have	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
22	regained	regaine	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
23	partial	partial	ADJ	JJ	Degree=Pos	_	_	_	_
24	sensitivity	sensitivity	NOUN	NN	Number=Sing	_	_	_	_
25	to	to	PART	TO	_	_	_	_	_
26	vincristine	vincristine	VERB	VB	VerbForm=Inf	_	_	_	SpaceAfter=No
27	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1310
# text = The finding that HL-60/vinc/R cells respond to TPA with induction of a monocytic phenotype, but not c-jun expression, suggests that c-jun induction is not obligatory for monocytic differentiation.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	finding	finding	NOUN	NN	Number=Sing	_	_	_	_
3	that	that	PRON	WDT	PronType=Rel	_	_	_	_
4	HL-60/vinc/	HL-60/vinc/	SYM	NFP	_	_	_	_	SpaceAfter=No
5	R	r	ADJ	JJ	Degree=Pos	_	_	_	_
6	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
7	respond	respond	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
8	to	to	ADP	IN	_	_	_	_	_
9	TPA	TPA	PROPN	NNP	Number=Sing	_	_	_	_
10	with	with	ADP	IN	_	_	_	_	_
11	induction	induction	NOUN	NN	Number=Sing	_	_	_	_
12	of	of	ADP	IN	_	_	_	_	_
13	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
14	monocytic	monocytic	ADJ	JJ	Degree=Pos	_	_	_	_
15	phenotype	phenotype	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
16	,	,	PUNCT	,	_	_	_	_	_
17	but	but	CCONJ	CC	_	_	_	_	_
18	not	not	ADV	RB	_	_	_	_	_
19	c-	c-	SYM	NFP	_	_	_	_	SpaceAfter=No
20	jun	jun	NOUN	NN	Number=Sing	_	_	_	_
21	expression	expression	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
22	,	,	PUNCT	,	_	_	_	_	_
23	suggests	suggest	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
24	that	that	SCONJ	IN	_	_	_	_	_
25	c-	c-	SYM	NFP	_	_	_	_	SpaceAfter=No
26	jun	jun	NOUN	NN	Number=Sing	_	_	_	_
27	induction	induction	NOUN	NN	Number=Sing	_	_	_	_
28	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
29	not	not	PART	RB	_	_	_	_	_
30	obligatory	obligatory	ADJ	JJ	Degree=Pos	_	_	_	_
31	for	for	ADP	IN	_	_	_	_	_
32	monocytic	monocytic	ADJ	JJ	Degree=Pos	_	_	_	_
33	differentiation	differentiation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
34	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1311
# text = Other studies further demonstrate that the jun-B and fra-1 genes are induced by TPA in both HL-60/vinc and HL-60/vinc/R cells, whereas c-fos expression is attenuated in the HL-60/vinc line.
1	Other	other	ADJ	JJ	Degree=Pos	_	_	_	_
2	studies	study	NOUN	NNS	Number=Plur	_	_	_	_
3	further	further	ADV	RB	_	_	_	_	_
4	demonstrate	demonstrate	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
5	that	that	SCONJ	IN	_	_	_	_	_
6	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
7	jun	jun	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
8	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
9	B	b	NOUN	NN	Number=Sing	_	_	_	_
10	and	and	CCONJ	CC	_	_	_	_	_
11	fra	fra	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
12	-1	-1	NUM	CD	NumType=Card	_	_	_	_
13	genes	gene	NOUN	NNS	Number=Plur	_	_	_	_
14	are	be	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
15	induced	induce	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
16	by	by	ADP	IN	_	_	_	_	_
17	TPA	TPa	PROPN	NNP	Number=Sing	_	_	_	_
18	in	in	ADP	IN	_	_	_	_	_
19	both	both	CCONJ	CC	_	_	_	_	_
20	HL-60	HL-60	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
21	/vinc	/vinc	NOUN	NN	Number=Sing	_	_	_	_
22	and	and	CCONJ	CC	_	_	_	_	_
23	HL-60/vinc/R	Hl-60/vinc/r	ADJ	JJ	Degree=Pos	_	_	_	_
24	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
25	,	,	PUNCT	,	_	_	_	_	_
26	whereas	wherea	SCONJ	IN	_	_	_	_	_
27	c-	c-	SYM	SYM	_	_	_	_	SpaceAfter=No
28	fos	fo	NOUN	NNS	Number=Plur	_	_	_	_
29	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
30	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
31	attenuated	attenuate	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
32	in	in	ADP	IN	_	_	_	_	_
33	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
34	HL	Hl	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
35	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
36	60	60	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
37	/	/	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
38	vinc	vinc	NOUN	NN	Number=Sing	_	_	_	_
39	line	line	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
40	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1312
# text = Since TPA activates protein kinase C (PKC), we examined translocation of PKC from the cytosol to the membrane fraction.
1	Since	since	SCONJ	IN	_	_	_	_	_
2	TPA	TPA	PROPN	NNP	Number=Sing	_	_	_	_
3	activates	activate	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
4	protein	protein	NOUN	NN	Number=Sing	_	_	_	_
5	kinase	kinase	NOUN	NN	Number=Sing	_	_	_	_
6	C	C	PROPN	NNP	Number=Sing	_	_	_	_
7	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
8	PKC	PKC	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
9	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
10	,	,	PUNCT	,	_	_	_	_	_
11	we	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
12	examined	examin	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
13	translocation	translocation	NOUN	NN	Number=Sing	_	_	_	_
14	of	of	ADP	IN	_	_	_	_	_
15	PKC	PKC	PROPN	NNP	Number=Sing	_	_	_	_
16	from	from	ADP	IN	_	_	_	_	_
17	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
18	cytosol	cytosol	NOUN	NN	Number=Sing	_	_	_	_
19	to	to	ADP	IN	_	_	_	_	_
20	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
21	membrane	membrane	NOUN	NN	Number=Sing	_	_	_	_
22	fraction	fraction	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
23	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1313
# text = Although HL-60 and HL-60/vinc/R cells demonstrated translocation of PKC activity, this subcellular redistribution was undetectable in HL-60/vinc cells.
1	Although	although	SCONJ	IN	_	_	_	_	_
2	HL	HL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
3	-	-	SYM	SYM	_	_	_	_	SpaceAfter=No
4	60	60	NUM	CD	NumType=Card	_	_	_	_
5	and	and	CCONJ	CC	_	_	_	_	_
6	HL-60/vinc/	HL-60/vinc/	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
7	R	be	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
8	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
9	demonstrated	demonstrate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
10	translocation	translocation	NOUN	NN	Number=Sing	_	_	_	_
11	of	of	ADP	IN	_	_	_	_	_
12	PKC	PKC	PROPN	NNP	Number=Sing	_	_	_	_
13	activity	activity	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
14	,	,	PUNCT	,	_	_	_	_	_
15	this	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
16	subcellular	subcellular	ADJ	JJ	Degree=Pos	_	_	_	_
17	redistribution	redistribution	NOUN	NN	Number=Sing	_	_	_	_
18	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
19	undetectable	undetectable	ADJ	JJ	Degree=Pos	_	_	_	_
20	in	in	ADP	IN	_	_	_	_	_
21	HL	HL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
22	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
23	60	60	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
24	/	/	PUNCT	,	_	_	_	_	SpaceAfter=No
25	vinc	vinc	NOUN	NN	Number=Sing	_	_	_	_
26	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
27	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1314
# text = Activity of the mitogen-activated protein kinase family with associated phosphorylation of c-Jun Y-peptide was markedly diminished in TPA-treated HL-60/vinc cells, but not in response to okadaic acid.
1	Activity	activity	NOUN	NN	Number=Sing	_	_	_	_
2	of	of	ADP	IN	_	_	_	_	_
3	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
4	mitogen	mitogen	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
5	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
6	activated	activate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
7	protein	protein	NOUN	NN	Number=Sing	_	_	_	_
8	kinase	kinase	NOUN	NN	Number=Sing	_	_	_	_
9	family	family	NOUN	NN	Number=Sing	_	_	_	_
10	with	with	ADP	IN	_	_	_	_	_
11	associated	associate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
12	phosphorylation	phosphorylation	NOUN	NN	Number=Sing	_	_	_	_
13	of	of	ADP	IN	_	_	_	_	_
14	c	c	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
15	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
16	Jun	Jun	PROPN	NNP	Number=Sing	_	_	_	_
17	Y-	y-	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
18	peptide	peptide	NOUN	NN	Number=Sing	_	_	_	_
19	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
20	markedly	markedly	ADV	RB	_	_	_	_	_
21	diminished	diminish	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
22	in	in	ADP	IN	_	_	_	_	_
23	TPA	TPA	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
24	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
25	treated	treat	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
26	HL	Hl	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
27	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
28	60	60	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
29	/	/	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
30	vinc	vinc	NOUN	NN	Number=Sing	_	_	_	_
31	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
32	,	,	PUNCT	,	_	_	_	_	_
33	but	but	CCONJ	CC	_	_	_	_	_
34	not	not	ADV	RB	_	_	_	_	_
35	in	in	ADP	IN	_	_	_	_	_
36	response	response	NOUN	NN	Number=Sing	_	_	_	_
37	to	to	ADP	IN	_	_	_	_	_
38	okadaic	okadaic	ADJ	JJ	Degree=Pos	_	_	_	_
39	acid	acid	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
40	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1315
# text = Taken together, these findings suggest that vincristine resistance confers insensitivity to TPA-induced differentiation and can include defects in PKC-mediated signaling events and induction of jun/fos early response gene expression.
1	Taken	take	PROPN	NNP	Number=Sing	_	_	_	_
2	together	together	ADV	RB	_	_	_	_	SpaceAfter=No
3	,	,	PUNCT	,	_	_	_	_	_
4	these	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
5	findings	finding	NOUN	NNS	Number=Plur	_	_	_	_
6	suggest	suggest	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
7	that	that	SCONJ	IN	_	_	_	_	_
8	vincristine	vincristine	ADJ	JJ	Degree=Pos	_	_	_	_
9	resistance	resistance	NOUN	NN	Number=Sing	_	_	_	_
10	confers	confer	NOUN	NNS	Number=Plur	_	_	_	_
11	insensitivity	insensitivity	ADV	RB	_	_	_	_	_
12	to	to	ADP	IN	_	_	_	_	_
13	TPA	TPA	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
14	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
15	induced	induce	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
16	differentiation	differentiation	NOUN	NN	Number=Sing	_	_	_	_
17	and	and	CCONJ	CC	_	_	_	_	_
18	can	can	AUX	MD	VerbForm=Fin	_	_	_	_
19	include	include	VERB	VB	VerbForm=Inf	_	_	_	_
20	defects	defect	NOUN	NNS	Number=Plur	_	_	_	_
21	in	in	ADP	IN	_	_	_	_	_
22	PKC	PKC	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
23	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
24	mediated	mediated	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
25	signaling	signaling	VERB	VBG	VerbForm=Ger	_	_	_	_
26	events	event	NOUN	NNS	Number=Plur	_	_	_	_
27	and	and	CCONJ	CC	_	_	_	_	_
28	induction	induction	NOUN	NN	Number=Sing	_	_	_	_
29	of	of	ADP	IN	_	_	_	_	_
30	jun	jun	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
31	/	/	PUNCT	,	_	_	_	_	SpaceAfter=No
32	fos	fo	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
33	early	early	ADJ	JJ	Degree=Pos	_	_	_	_
34	response	response	NOUN	NN	Number=Sing	_	_	_	_
35	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
36	expression	expression	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
37	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 1316
# text = Document 003002466 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	003002466	003002466	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 1317
# text = HMG-I binds to GATA motifs: implications for an HPFH syndrome.
1	HMG	Hmg	INTJ	UH	_	_	_	_	SpaceAfter=No
2	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
3	I	I	PRON	PRP	Case=Nom|Number=Sing|Person=1|PronType=Prs	_	_	_	_
4	binds	bind	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
5	to	to	ADP	IN	_	_	_	_	_
6	GATA	GATa	PROPN	NNP	Number=Sing	_	_	_	_
7	motifs	motif	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
8	:	:	PUNCT	:	_	_	_	_	_
9	implications	implication	NOUN	NNS	Number=Plur	_	_	_	_
10	for	for	ADP	IN	_	_	_	_	_
11	an	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
12	HPFH	Hpfh	ADJ	JJ	Degree=Pos	_	_	_	_
13	syndrome	syndrome	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
14	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 1318
# text = We have examined binding of the nuclear protein HMG-I to the human gamma-globin promoter.
1	We	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
2	have	have	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
3	examined	examine	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
4	binding	binding	VERB	VBG	VerbForm=Ger	_	_	_	_
5	of	of	ADP	IN	_	_	_	_	_
6	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
7	nuclear	nuclear	ADJ	JJ	Degree=Pos	_	_	_	_
8	protein	protein	NOUN	NN	Number=Sing	_	_	_	_
9	HMG	Hmg	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
10	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
11	I	I	PRON	PRP	Case=Nom|Number=Sing|Person=1|PronType=Prs	_	_	_	_
12	to	to	ADP	IN	_	_	_	_	_
13	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
14	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
15	gamma	gamma	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
16	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
17	globin	globin	NOUN	NN	Number=Sing	_	_	_	_
18	promoter	promoter	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
19	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1319
# text = We find that HMG-I binds preferentially to the more 3' of a pair of GATA motifs in the gamma-globin promoter; this paired motif is bound by the erythroid factor GATA-1.
1	We	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
2	find	find	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
3	that	that	SCONJ	IN	_	_	_	_	_
4	HMG	Hmg	VERB	VBG	VerbForm=Ger	_	_	_	SpaceAfter=No
5	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
6	I	I	PRON	PRP	Case=Nom|Number=Sing|Person=1|PronType=Prs	_	_	_	_
7	binds	bind	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
8	preferentially	preferentially	ADV	RB	_	_	_	_	_
9	to	to	ADP	IN	_	_	_	_	_
10	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
11	more	more	ADJ	JJR	Degree=Cmp	_	_	_	_
12	3	3	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
13	'	'	NOUN	NNS	Number=Plur	_	_	_	_
14	of	of	ADP	IN	_	_	_	_	_
15	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
16	pair	pair	NOUN	NN	Number=Sing	_	_	_	_
17	of	of	ADP	IN	_	_	_	_	_
18	GATA	GATA	PROPN	NNP	Number=Sing	_	_	_	_
19	motifs	motif	NOUN	NNS	Number=Plur	_	_	_	_
20	in	in	ADP	IN	_	_	_	_	_
21	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
22	gamma	gamma	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
23	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
24	globin	globin	NOUN	NN	Number=Sing	_	_	_	_
25	promoter	promoter	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
26	;	;	PUNCT	,	_	_	_	_	_
27	this	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
28	paired	paired	ADJ	JJ	Degree=Pos	_	_	_	_
29	motif	motif	NOUN	NN	Number=Sing	_	_	_	_
30	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
31	bound	bound	ADJ	JJ	Degree=Pos	_	_	_	_
32	by	by	ADP	IN	_	_	_	_	_
33	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
34	erythroid	erythroid	ADJ	JJ	Degree=Pos	_	_	_	_
35	factor	factor	NOUN	NN	Number=Sing	_	_	_	_
36	GATA	GATa	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
37	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
38	1	1	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
39	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1320
# text = A naturally occurring mutation (-175 T-C) in the area bound by HMG-I results in overexpression of gamma-globin in adult red blood cells (HPFH) and up-regulation of the gamma-globin promoter in in vitro expression assays; HMG-I does not bind to this mutant sequence.
1	A	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
2	naturally	naturally	ADV	RB	_	_	_	_	_
3	occurring	occurre	ADJ	JJ	Degree=Pos	_	_	_	_
4	mutation	mutation	NOUN	NN	Number=Sing	_	_	_	_
5	(-	(-	PUNCT	.	_	_	_	_	SpaceAfter=No
6	175	175	NUM	CD	NumType=Card	_	_	_	_
7	T	T	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
8	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
9	C	C	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
10	)	)	PUNCT	-RRB-	_	_	_	_	_
11	in	in	ADP	IN	_	_	_	_	_
12	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
13	area	area	NOUN	NN	Number=Sing	_	_	_	_
14	bound	bound	ADJ	JJ	Degree=Pos	_	_	_	_
15	by	by	ADP	IN	_	_	_	_	_
16	HMG	HMG	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
17	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
18	I	I	PRON	PRP	Case=Nom|Number=Sing|Person=1|PronType=Prs	_	_	_	_
19	results	result	NOUN	NNS	Number=Plur	_	_	_	_
20	in	in	ADP	IN	_	_	_	_	_
21	overexpression	overexpression	NOUN	NN	Number=Sing	_	_	_	_
22	of	of	ADP	IN	_	_	_	_	_
23	gamma	gamma	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
24	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
25	globin	globin	NOUN	NN	Number=Sing	_	_	_	_
26	in	in	ADP	IN	_	_	_	_	_
27	adult	adult	ADJ	JJ	Degree=Pos	_	_	_	_
28	red	red	ADJ	JJ	Degree=Pos	_	_	_	_
29	blood	blood	NOUN	NN	Number=Sing	_	_	_	_
30	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
31	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
32	HPFH	HPFH	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
33	)	)	PUNCT	-RRB-	_	_	_	_	_
34	and	and	CCONJ	CC	_	_	_	_	_
35	up	up	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
36	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
37	regulation	regulation	NOUN	NN	Number=Sing	_	_	_	_
38	of	of	ADP	IN	_	_	_	_	_
39	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
40	gamma	gamma	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
41	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
42	globin	globin	NOUN	NN	Number=Sing	_	_	_	_
43	promoter	promoter	NOUN	NN	Number=Sing	_	_	_	_
44	in	in	ADP	IN	_	_	_	_	_
45	in	in	ADP	IN	_	_	_	_	_
46	vitro	vitro	NUM	CD	NumType=Card	_	_	_	_
47	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
48	assays	assay	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
49	;	;	PUNCT	,	_	_	_	_	_
50	HMG	Hmg	INTJ	UH	_	_	_	_	SpaceAfter=No
51	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
52	I	I	PRON	PRP	Case=Nom|Number=Sing|Person=1|PronType=Prs	_	_	_	_
53	does	do	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
54	not	not	PART	RB	_	_	_	_	_
55	bind	bind	VERB	VB	VerbForm=Inf	_	_	_	_
56	to	to	ADP	IN	_	_	_	_	_
57	this	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
58	mutant	mutant	ADJ	JJ	Degree=Pos	_	_	_	_
59	sequence	sequence	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
60	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1321
# text = A survey of GATA motifs from other globin cis-elements demonstrates HMG-I binding to most of them.
1	A	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
2	survey	survey	NOUN	NN	Number=Sing	_	_	_	_
3	of	of	ADP	IN	_	_	_	_	_
4	GATA	GATA	PROPN	NNP	Number=Sing	_	_	_	_
5	motifs	motif	NOUN	NNS	Number=Plur	_	_	_	_
6	from	from	ADP	IN	_	_	_	_	_
7	other	other	ADJ	JJ	Degree=Pos	_	_	_	_
8	globin	globin	NOUN	NN	Number=Sing	_	_	_	_
9	cis	cis	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
10	-	-	PUNCT	:	_	_	_	_	SpaceAfter=No
11	elements	element	NOUN	NNS	Number=Plur	_	_	_	_
12	demonstrates	demonstrate	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
13	HMG	Hmg	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
14	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
15	I	I	PRON	PRP	Case=Nom|Number=Sing|Person=1|PronType=Prs	_	_	_	_
16	binding	bind	VERB	VBG	VerbForm=Ger	_	_	_	_
17	to	to	ADP	IN	_	_	_	_	_
18	most	most	ADJ	JJS	Degree=Sup	_	_	_	_
19	of	of	ADP	IN	_	_	_	_	_
20	them	they	PRON	PRP	Case=Acc|Number=Plur|Person=3|PronType=Prs	_	_	_	SpaceAfter=No
21	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1322
# text = These findings implicate HMG-I in the HPFH phenotype; we speculate that it may participate in the formation of multiprotein complexes that regulate globin gene expression.
1	These	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
2	findings	finding	NOUN	NNS	Number=Plur	_	_	_	_
3	implicate	implicate	ADJ	JJ	Degree=Pos	_	_	_	_
4	HMG	Hmg	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
5	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
6	I	I	PRON	PRP	Case=Nom|Number=Sing|Person=1|PronType=Prs	_	_	_	_
7	in	in	ADP	IN	_	_	_	_	_
8	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
9	HPFH	Hpfh	ADJ	JJ	Degree=Pos|NumType=Ord	_	_	_	_
10	phenotype	phenotype	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
11	;	;	PUNCT	,	_	_	_	_	_
12	we	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
13	speculate	speculate	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
14	that	that	SCONJ	IN	_	_	_	_	_
15	it	it	PRON	PRP	Case=Nom|Gender=Neut|Number=Sing|Person=3|PronType=Prs	_	_	_	_
16	may	may	AUX	MD	VerbForm=Fin	_	_	_	_
17	participate	participate	VERB	VB	VerbForm=Inf	_	_	_	_
18	in	in	ADP	IN	_	_	_	_	_
19	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
20	formation	formation	NOUN	NN	Number=Sing	_	_	_	_
21	of	of	ADP	IN	_	_	_	_	_
22	multiprotein	multiprotein	ADJ	JJ	Degree=Pos	_	_	_	_
23	complexes	complex	NOUN	NNS	Number=Plur	_	_	_	_
24	that	that	PRON	WDT	PronType=Rel	_	_	_	_
25	regulate	regulate	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
26	globin	globin	ADJ	JJ	Degree=Pos	_	_	_	_
27	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
28	expression	expression	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
29	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 1323
# text = Document 003002468 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	003002468	003002468	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 1324
# text = A nongenomic mechanism for progesterone-mediated immunosuppression: inhibition of K+ channels, Ca2+ signaling, and gene expression in T lymphocytes.
1	A	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
2	nongenomic	nongenomic	ADJ	JJ	Degree=Pos	_	_	_	_
3	mechanism	mechanism	NOUN	NN	Number=Sing	_	_	_	_
4	for	for	ADP	IN	_	_	_	_	_
5	progesterone	progesterone	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	SpaceAfter=No
6	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
7	mediated	mediate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
8	immunosuppression	immunosuppression	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
9	:	:	PUNCT	:	_	_	_	_	_
10	inhibition	inhibition	NOUN	NN	Number=Sing	_	_	_	_
11	of	of	ADP	IN	_	_	_	_	_
12	K	k	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
13	+	+	SYM	SYM	_	_	_	_	_
14	channels	channel	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
15	,	,	PUNCT	,	_	_	_	_	_
16	Ca2	Ca2	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
17	+	+	SYM	SYM	_	_	_	_	_
18	signaling	signaling	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
19	,	,	PUNCT	,	_	_	_	_	_
20	and	and	CCONJ	CC	_	_	_	_	_
21	gene	gene	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
22	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
23	in	in	ADP	IN	_	_	_	_	_
24	T	t	PROPN	NNP	Number=Sing	_	_	_	_
25	lymphocytes	lymphocyte	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
26	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 1325
# text = The mechanism by which progesterone causes localized suppression of the immune response during pregnancy has remained elusive.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	mechanism	mechanism	NOUN	NN	Number=Sing	_	_	_	_
3	by	by	ADP	IN	_	_	_	_	_
4	which	which	PRON	WDT	PronType=Rel	_	_	_	_
5	progesterone	progesterone	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
6	causes	cause	NOUN	NNS	Number=Plur	_	_	_	_
7	localized	localize	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
8	suppression	suppression	NOUN	NN	Number=Sing	_	_	_	_
9	of	of	ADP	IN	_	_	_	_	_
10	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
11	immune	immune	ADJ	JJ	Degree=Pos	_	_	_	_
12	response	response	NOUN	NN	Number=Sing	_	_	_	_
13	during	during	ADP	IN	_	_	_	_	_
14	pregnancy	pregnancy	NOUN	NN	Number=Sing	_	_	_	_
15	has	have	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
16	remained	remain	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
17	elusive	elusive	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
18	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1326
# text = Using human T lymphocytes and T cell lines, we show that progesterone, at concentrations found in the placenta, rapidly and reversibly blocks voltage-gated and calcium-activated K+ channels (KV and KCa, respectively), resulting in depolarization of the membrane potential.
1	Using	use	VERB	VBG	VerbForm=Ger	_	_	_	_
2	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
3	T	t	PROPN	NNP	Number=Sing	_	_	_	_
4	lymphocytes	lymphocyte	NOUN	NNS	Number=Plur	_	_	_	_
5	and	and	CCONJ	CC	_	_	_	_	_
6	T	t	PROPN	NNP	Number=Sing	_	_	_	_
7	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
8	lines	line	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
9	,	,	PUNCT	,	_	_	_	_	_
10	we	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
11	show	show	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
12	that	that	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
13	progesterone	progesterone	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
14	,	,	PUNCT	,	_	_	_	_	_
15	at	at	ADP	IN	_	_	_	_	_
16	concentrations	concentration	NOUN	NNS	Number=Plur	_	_	_	_
17	found	find	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
18	in	in	ADP	IN	_	_	_	_	_
19	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
20	placenta	placenta	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
21	,	,	PUNCT	,	_	_	_	_	_
22	rapidly	rapidly	ADV	RB	_	_	_	_	_
23	and	and	CCONJ	CC	_	_	_	_	_
24	reversibly	reversibly	ADV	RB	_	_	_	_	_
25	blocks	block	NOUN	NNS	Number=Plur	_	_	_	_
26	voltage	voltage	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
27	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
28	gated	gate	ADJ	JJ	Degree=Pos	_	_	_	_
29	and	and	CCONJ	CC	_	_	_	_	_
30	calcium-	calcium-	SYM	NFP	_	_	_	_	SpaceAfter=No
31	activated	activate	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
32	K	k	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
33	+	+	SYM	SYM	_	_	_	_	_
34	channels	channel	NOUN	NNS	Number=Plur	_	_	_	_
35	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
36	KV	KV	PROPN	NNP	Number=Sing	_	_	_	_
37	and	and	CCONJ	CC	_	_	_	_	_
38	KCa	KCa	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
39	,	,	PUNCT	,	_	_	_	_	_
40	respectively	respectively	ADV	RB	_	_	_	_	SpaceAfter=No
41	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
42	,	,	PUNCT	,	_	_	_	_	_
43	resulting	result	VERB	VBG	VerbForm=Ger	_	_	_	_
44	in	in	ADP	IN	_	_	_	_	_
45	depolarization	depolarization	NOUN	NN	Number=Sing	_	_	_	_
46	of	of	ADP	IN	_	_	_	_	_
47	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
48	membrane	membrane	NOUN	NN	Number=Sing	_	_	_	_
49	potential	potential	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
50	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1327
# text = As a result, Ca2+ signaling and nuclear factor of activated T cells (NF-AT)-driven gene expression are inhibited.
1	As	as	ADP	IN	_	_	_	_	_
2	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
3	result	result	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
4	,	,	PUNCT	,	_	_	_	_	_
5	Ca2	Ca2	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
6	+	+	SYM	SYM	_	_	_	_	_
7	signaling	signaling	NOUN	NN	Number=Sing	_	_	_	_
8	and	and	CCONJ	CC	_	_	_	_	_
9	nuclear	nuclear	ADJ	JJ	Degree=Pos	_	_	_	_
10	factor	factor	NOUN	NN	Number=Sing	_	_	_	_
11	of	of	ADP	IN	_	_	_	_	_
12	activated	activated	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
13	T	T	PROPN	NNP	Number=Sing	_	_	_	_
14	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
15	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
16	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
17	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
18	AT	AT	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
19	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
20	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
21	driven	drive	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
22	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
23	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
24	are	be	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
25	inhibited	inhibit	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	SpaceAfter=No
26	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1328
# text = Progesterone acts distally to the initial steps of T cell receptor (TCR)-mediated signal transduction, since it blocks sustained Ca2+ signals after thapsigargin stimulation, as well as oscillatory Ca2+ signals, but not the Ca2+ transient after TCR stimulation.
1	Progesterone	Progesterone	PRON	NN	Number=Sing	_	_	_	_
2	acts	act	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
3	distally	distally	ADV	RB	_	_	_	_	_
4	to	to	ADP	IN	_	_	_	_	_
5	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
6	initial	initial	ADJ	JJ	Degree=Pos	_	_	_	_
7	steps	step	NOUN	NNS	Number=Plur	_	_	_	_
8	of	of	ADP	IN	_	_	_	_	_
9	T	t	PROPN	NNP	Number=Sing	_	_	_	_
10	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
11	receptor	receptor	NOUN	NN	Number=Sing	_	_	_	_
12	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
13	TCR	TCR	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
14	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
15	-	-	PUNCT	:	_	_	_	_	SpaceAfter=No
16	mediated	mediate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
17	signal	signal	NOUN	NN	Number=Sing	_	_	_	_
18	transduction	transduction	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
19	,	,	PUNCT	,	_	_	_	_	_
20	since	since	SCONJ	IN	_	_	_	_	_
21	it	it	PRON	PRP	Case=Nom|Gender=Neut|Number=Sing|Person=3|PronType=Prs	_	_	_	_
22	blocks	block	NOUN	NNS	Number=Plur	_	_	_	_
23	sustained	sustain	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
24	Ca2	ca2	PART	TO	Abbr=Yes	_	_	_	SpaceAfter=No
25	+	+	SYM	SYM	_	_	_	_	_
26	signals	signal	NOUN	NNS	Number=Plur	_	_	_	_
27	after	after	ADP	IN	_	_	_	_	_
28	thapsigargin	thapsigargin	NOUN	NN	Number=Sing	_	_	_	_
29	stimulation	stimulation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
30	,	,	PUNCT	,	_	_	_	_	_
31	as	as	ADV	RB	_	_	_	_	_
32	well	well	ADV	RB	Degree=Pos	_	_	_	_
33	as	as	ADP	IN	_	_	_	_	_
34	oscillatory	oscillatory	ADJ	JJ	Degree=Pos	_	_	_	_
35	Ca2	ca2	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
36	+	+	SYM	SYM	_	_	_	_	_
37	signals	signal	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
38	,	,	PUNCT	,	_	_	_	_	_
39	but	but	CCONJ	CC	_	_	_	_	_
40	not	not	ADV	RB	_	_	_	_	_
41	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
42	Ca2	ca2	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
43	+	+	SYM	SYM	_	_	_	_	_
44	transient	transient	NOUN	NN	Number=Sing	_	_	_	_
45	after	after	ADP	IN	_	_	_	_	_
46	TCR	Tcr	NOUN	NN	Number=Sing	_	_	_	_
47	stimulation	stimulation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
48	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1329
# text = K+
1	K	K	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
2	+	+	SYM	NFP	_	_	_	_	_

# sent_id = 1330
# text = channel blockade by progesterone is specific; other steroid hormones had little or no effect, although the progesterone antagonist RU 486 also blocked KV and KCa channels.
1	channel	channel	NOUN	NN	Number=Sing	_	_	_	_
2	blockade	blockake	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
3	by	by	ADP	IN	_	_	_	_	_
4	progesterone	progesterone	NOUN	NN	Number=Sing	_	_	_	_
5	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
6	specific	specific	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
7	;	;	PUNCT	,	_	_	_	_	_
8	other	other	ADJ	JJ	Degree=Pos	_	_	_	_
9	steroid	steroid	ADJ	JJ	Degree=Pos	_	_	_	_
10	hormones	hormone	NOUN	NNS	Number=Plur	_	_	_	_
11	had	have	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
12	little	little	ADJ	JJ	Degree=Pos	_	_	_	_
13	or	or	CCONJ	CC	_	_	_	_	_
14	no	no	DET	DT	_	_	_	_	_
15	effect	effect	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
16	,	,	PUNCT	,	_	_	_	_	_
17	although	although	SCONJ	IN	_	_	_	_	_
18	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
19	progesterone	progesterone	NOUN	NN	Number=Sing	_	_	_	_
20	antagonist	antagonist	NOUN	NN	Number=Sing	_	_	_	_
21	RU	Ru	PROPN	NNP	Number=Sing	_	_	_	_
22	486	486	NUM	CD	NumType=Card	_	_	_	_
23	also	also	ADV	RB	_	_	_	_	_
24	blocked	block	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
25	KV	KV	PROPN	NNP	Number=Sing	_	_	_	_
26	and	and	CCONJ	CC	_	_	_	_	_
27	KCa	KCa	PROPN	NNP	Number=Sing	_	_	_	_
28	channels	channel	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
29	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1331
# text = Progesterone effectively blocked a broad spectrum of K+ channels, reducing both Kv1.3 and charybdotoxin-resistant components of KV current and KCa current in T cells, as well as blocking several cloned KV channels expressed in cell lines.
1	Progesterone	Progesterone	PROPN	NNP	Number=Sing	_	_	_	_
2	effectively	effectively	ADV	RB	_	_	_	_	_
3	blocked	block	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
4	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
5	broad	broad	ADJ	JJ	Degree=Pos	_	_	_	_
6	spectrum	spectrum	NOUN	NN	Number=Sing	_	_	_	_
7	of	of	ADP	IN	_	_	_	_	_
8	K	k	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
9	+	+	SYM	SYM	_	_	_	_	_
10	channels	channel	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
11	,	,	PUNCT	,	_	_	_	_	_
12	reducing	reduce	VERB	VBG	VerbForm=Ger	_	_	_	_
13	both	both	DET	DT	_	_	_	_	_
14	Kv1.3	Kv1.3	NOUN	NN	Number=Sing	_	_	_	_
15	and	and	CCONJ	CC	_	_	_	_	_
16	charybdotoxin	charybdotoxin	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
17	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
18	resistant	resistant	NOUN	NN	Number=Sing	_	_	_	_
19	components	component	NOUN	NNS	Number=Plur	_	_	_	_
20	of	of	ADP	IN	_	_	_	_	_
21	KV	KV	PROPN	NNP	Number=Sing	_	_	_	_
22	current	current	PROPN	NNP	Number=Sing	_	_	_	_
23	and	and	CCONJ	CC	_	_	_	_	_
24	KCa	KCa	PROPN	NNP	Number=Sing	_	_	_	_
25	current	current	ADJ	JJ	Degree=Pos	_	_	_	_
26	in	in	ADP	IN	_	_	_	_	_
27	T	t	PROPN	NNP	Number=Sing	_	_	_	_
28	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
29	,	,	PUNCT	,	_	_	_	_	_
30	as	as	ADV	RB	_	_	_	_	_
31	well	well	ADV	RB	Degree=Pos	_	_	_	_
32	as	as	SCONJ	IN	_	_	_	_	_
33	blocking	block	VERB	VBG	VerbForm=Ger	_	_	_	_
34	several	several	ADJ	JJ	Degree=Pos	_	_	_	_
35	cloned	clon	ADJ	JJ	Degree=Pos	_	_	_	_
36	KV	Kv	PROPN	NNP	Number=Sing	_	_	_	_
37	channels	channel	NOUN	NNS	Number=Plur	_	_	_	_
38	expressed	express	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
39	in	in	ADP	IN	_	_	_	_	_
40	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
41	lines	line	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
42	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1332
# text = Progesterone had little or no effect on a cloned voltage-gated Na+ channel, an inward rectifier K+ channel, or on lymphocyte Ca2+ and Cl- channels.
1	Progesterone	Progesterone	PRON	NN	Number=Sing	_	_	_	_
2	had	have	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
3	little	little	ADJ	JJ	Degree=Pos	_	_	_	_
4	or	or	CCONJ	CC	_	_	_	_	_
5	no	no	DET	DT	_	_	_	_	_
6	effect	effect	NOUN	NN	Number=Sing	_	_	_	_
7	on	on	ADP	IN	_	_	_	_	_
8	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
9	cloned	clon	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
10	voltage	voltage	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
11	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
12	gated	gate	ADJ	JJ	Degree=Pos	_	_	_	_
13	Na	na	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
14	+	+	SYM	SYM	_	_	_	_	_
15	channel	channel	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
16	,	,	PUNCT	,	_	_	_	_	_
17	an	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
18	inward	inward	ADJ	JJ	Degree=Pos	_	_	_	_
19	rectifier	rectifier	NOUN	NN	Number=Sing	_	_	_	_
20	K	k	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
21	+	+	SYM	SYM	_	_	_	_	_
22	channel	channel	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
23	,	,	PUNCT	,	_	_	_	_	_
24	or	or	CCONJ	CC	_	_	_	_	_
25	on	on	ADP	IN	_	_	_	_	_
26	lymphocyte	lymphocyte	NOUN	NN	Number=Sing	_	_	_	_
27	Ca2	ca2	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
28	+	+	SYM	SYM	_	_	_	_	_
29	and	and	CCONJ	CC	_	_	_	_	_
30	Cl	Cl	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
31	-	-	PUNCT	HYPH	_	_	_	_	_
32	channels	channel	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
33	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1333
# text = We propose that direct inhibition of K+ channels in T cells by progesterone contributes to progesterone-induced immunosuppression.
1	We	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
2	propose	propose	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
3	that	that	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
4	direct	direct	ADJ	JJ	Degree=Pos	_	_	_	_
5	inhibition	inhibition	NOUN	NN	Number=Sing	_	_	_	_
6	of	of	ADP	IN	_	_	_	_	_
7	K	k	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
8	+	+	SYM	SYM	_	_	_	_	_
9	channels	channel	NOUN	NNS	Number=Plur	_	_	_	_
10	in	in	ADP	IN	_	_	_	_	_
11	T	t	PROPN	NNP	Number=Sing	_	_	_	_
12	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
13	by	by	ADP	IN	_	_	_	_	_
14	progesterone	progesterone	ADJ	JJ	Degree=Pos	_	_	_	_
15	contributes	contribute	NOUN	NNS	Number=Plur	_	_	_	_
16	to	to	PART	TO	_	_	_	_	_
17	progesterone	progesterone	VERB	VB	VerbForm=Inf	_	_	_	SpaceAfter=No
18	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
19	induced	induce	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
20	immunosuppression	immunosuppression	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
21	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 1334
# text = Document 003002472 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	003002472	003002472	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 1335
# text = Involvement of Rel, Fos, and Jun proteins in binding activity to the IL-2 promoter CD28 response element/AP-1 sequence in human T cells.
1	Involvement	involvement	NOUN	NN	Number=Sing	_	_	_	_
2	of	of	ADP	IN	_	_	_	_	_
3	Rel	Rel	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
4	,	,	PUNCT	,	_	_	_	_	_
5	Fos	Fos	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
6	,	,	PUNCT	,	_	_	_	_	_
7	and	and	CCONJ	CC	_	_	_	_	_
8	Jun	Jun	PROPN	NNP	Number=Sing	_	_	_	_
9	proteins	protein	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
10	in	in	SCONJ	IN	_	_	_	_	_
11	binding	bind	VERB	VBG	VerbForm=Ger	_	_	_	_
12	activity	activity	NOUN	NN	Number=Sing	_	_	_	_
13	to	to	ADP	IN	_	_	_	_	_
14	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
15	IL	Il	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
16	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
17	2	2	NUM	CD	NumType=Card	_	_	_	_
18	promoter	promoter	NOUN	NN	Number=Sing	_	_	_	_
19	CD28	CD28	NUM	CD	NumType=Card	_	_	_	_
20	response	response	NOUN	NN	Number=Sing	_	_	_	_
21	element	element	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
22	/	/	PUNCT	,	_	_	_	_	SpaceAfter=No
23	AP	ap	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
24	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
25	1	1	NUM	CD	NumType=Card	_	_	_	_
26	sequence	sequence	NOUN	NN	Number=Sing	_	_	_	_
27	in	in	ADP	IN	_	_	_	_	_
28	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
29	T	t	PROPN	NNP	Number=Sing	_	_	_	_
30	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
31	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 1336
# text = CD28 is an important costimulatory molecule in the activation of human T cells.
1	CD28	Cd28	PROPN	NNP	Number=Sing	_	_	_	_
2	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
3	an	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
4	important	important	ADJ	JJ	Degree=Pos	_	_	_	_
5	costimulatory	costimulatory	NOUN	NN	Number=Sing	_	_	_	_
6	molecule	molecule	NOUN	NN	Number=Sing	_	_	_	_
7	in	in	ADP	IN	_	_	_	_	_
8	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
9	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
10	of	of	ADP	IN	_	_	_	_	_
11	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
12	T	t	PROPN	NNP	Number=Sing	_	_	_	_
13	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
14	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1337
# text = Costimulation of T cells through both the Ag receptor and CD28 leads to high level IL-2 production, which is vital to the development of an immune response in vivo.
1	Costimulation	Costimulation	NOUN	NN	Number=Sing	_	_	_	_
2	of	of	ADP	IN	_	_	_	_	_
3	T	t	PROPN	NNP	Number=Sing	_	_	_	_
4	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
5	through	through	ADP	IN	_	_	_	_	_
6	both	both	CCONJ	CC	_	_	_	_	_
7	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
8	Ag	ag	ADJ	JJ	Degree=Pos	_	_	_	_
9	receptor	receptor	NOUN	NN	Number=Sing	_	_	_	_
10	and	and	CCONJ	CC	_	_	_	_	_
11	CD28	Cd28	NOUN	NN	Number=Sing	_	_	_	_
12	leads	lead	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
13	to	to	ADP	IN	_	_	_	_	_
14	high	high	ADJ	JJ	Degree=Pos	_	_	_	_
15	level	level	NOUN	NN	Number=Sing	_	_	_	_
16	IL	Il	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
17	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
18	2	2	NUM	CD	NumType=Card	_	_	_	_
19	production	production	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
20	,	,	PUNCT	,	_	_	_	_	_
21	which	which	PRON	WDT	PronType=Rel	_	_	_	_
22	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
23	vital	vital	ADJ	JJ	Degree=Pos	_	_	_	_
24	to	to	ADP	IN	_	_	_	_	_
25	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
26	development	development	NOUN	NN	Number=Sing	_	_	_	_
27	of	of	ADP	IN	_	_	_	_	_
28	an	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
29	immune	immune	ADJ	JJ	Degree=Pos	_	_	_	_
30	response	response	NOUN	NN	Number=Sing	_	_	_	_
31	in	in	ADP	IN	_	_	_	_	_
32	vivo	vivo	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
33	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1338
# text = Previous reports have suggested the CD28 stimulation contributes to the activation of the IL-2 promoter by up-regulating the activity of several transcription factors, including AP-1 and nuclear factor-kappaB (NF-kappaB)/Rel family members as well as an uncharacterized transcription factor called CD28 response complex.
1	Previous	previous	ADJ	JJ	Degree=Pos	_	_	_	_
2	reports	report	NOUN	NNS	Number=Plur	_	_	_	_
3	have	have	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
4	suggested	suggest	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
5	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
6	CD28	CD28	PROPN	NNP	Number=Sing	_	_	_	_
7	stimulation	stimulation	NOUN	NN	Number=Sing	_	_	_	_
8	contributes	contribute	NOUN	NNS	Number=Plur	_	_	_	_
9	to	to	ADP	IN	_	_	_	_	_
10	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
11	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
12	of	of	ADP	IN	_	_	_	_	_
13	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
14	IL	Il	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
15	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
16	2	2	NUM	CD	NumType=Card	_	_	_	_
17	promoter	promoter	NOUN	NN	Number=Sing	_	_	_	_
18	by	by	ADP	IN	_	_	_	_	_
19	up	up	ADV	RB	_	_	_	_	SpaceAfter=No
20	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
21	regulating	regulate	VERB	VBG	VerbForm=Ger	_	_	_	_
22	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
23	activity	activity	NOUN	NN	Number=Sing	_	_	_	_
24	of	of	ADP	IN	_	_	_	_	_
25	several	several	ADJ	JJ	Degree=Pos	_	_	_	_
26	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
27	factors	factor	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
28	,	,	PUNCT	,	_	_	_	_	_
29	including	include	VERB	VBG	VerbForm=Ger	_	_	_	_
30	AP	ap	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
31	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
32	1	1	NUM	CD	NumType=Card	_	_	_	_
33	and	and	CCONJ	CC	_	_	_	_	_
34	nuclear	nuclear	ADJ	JJ	Degree=Pos	_	_	_	_
35	factor	factor	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
36	-kappaB	-kappaB	PROPN	NNP	Number=Sing	_	_	_	_
37	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
38	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
39	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
40	kappaB	kappaB	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
41	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
42	/	/	PUNCT	,	_	_	_	_	SpaceAfter=No
43	Rel	Rel	PROPN	NNP	Number=Sing	_	_	_	_
44	family	family	NOUN	NN	Number=Sing	_	_	_	_
45	members	member	NOUN	NNS	Number=Plur	_	_	_	_
46	as	as	ADV	RB	_	_	_	_	_
47	well	well	ADV	RB	Degree=Pos	_	_	_	_
48	as	as	ADP	IN	_	_	_	_	_
49	an	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
50	uncharacterized	uncharacterized	ADJ	JJ	Degree=Pos	_	_	_	_
51	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
52	factor	factor	NOUN	NN	Number=Sing	_	_	_	_
53	called	call	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
54	CD28	CD28	NUM	CD	NumType=Card	_	_	_	_
55	response	response	NOUN	NN	Number=Sing	_	_	_	_
56	complex	complex	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
57	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1339
# text = While several lines of investigation have suggested that NF-kappaB/Rel family members make up the CD28 response complex transcription factor, other work has not supported this conclusion.
1	While	while	SCONJ	IN	_	_	_	_	_
2	several	several	ADJ	JJ	Degree=Pos	_	_	_	_
3	lines	line	NOUN	NNS	Number=Plur	_	_	_	_
4	of	of	ADP	IN	_	_	_	_	_
5	investigation	investigation	NOUN	NN	Number=Sing	_	_	_	_
6	have	have	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
7	suggested	suggest	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
8	that	that	SCONJ	IN	_	_	_	_	_
9	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
10	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
11	kappaB	kappaB	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
12	/	/	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
13	Rel	Rel	PROPN	NNP	Number=Sing	_	_	_	_
14	family	family	NOUN	NN	Number=Sing	_	_	_	_
15	members	member	NOUN	NNS	Number=Plur	_	_	_	_
16	make	make	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
17	up	up	ADP	RP	_	_	_	_	_
18	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
19	CD28	CD28	PROPN	NNP	Number=Sing	_	_	_	_
20	response	response	NOUN	NN	Number=Sing	_	_	_	_
21	complex	complex	NUM	CD	NumType=Card	_	_	_	_
22	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
23	factor	factor	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
24	,	,	PUNCT	,	_	_	_	_	_
25	other	other	ADJ	JJ	Degree=Pos	_	_	_	_
26	work	work	NOUN	NN	Number=Sing	_	_	_	_
27	has	have	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
28	not	not	PART	RB	_	_	_	_	_
29	supported	support	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
30	this	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
31	conclusion	conclusion	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
32	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1340
# text = Recent studies suggest that the CD28 response element (CD28RE) does not function independently but works instead in conjunction with the adjacent promoter proximal AP-1-binding site and this hypothesis is confirmed here.
1	Recent	recent	ADJ	JJ	Degree=Pos	_	_	_	_
2	studies	study	NOUN	NNS	Number=Plur	_	_	_	_
3	suggest	suggest	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
4	that	that	SCONJ	IN	_	_	_	_	_
5	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
6	CD28	Cd28	NOUN	NN	Number=Sing	_	_	_	_
7	response	response	NOUN	NN	Number=Sing	_	_	_	_
8	element	element	NOUN	NN	Number=Sing	_	_	_	_
9	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
10	CD28RE	Cd28re	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
11	)	)	PUNCT	-RRB-	_	_	_	_	_
12	does	do	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
13	not	not	PART	RB	_	_	_	_	_
14	function	function	VERB	VB	VerbForm=Inf	_	_	_	_
15	independently	independently	ADV	RB	_	_	_	_	_
16	but	but	CCONJ	CC	_	_	_	_	_
17	works	work	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
18	instead	instead	ADV	RB	_	_	_	_	_
19	in	in	ADP	IN	_	_	_	_	_
20	conjunction	conjunction	NOUN	NN	Number=Sing	_	_	_	_
21	with	with	ADP	IN	_	_	_	_	_
22	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
23	adjacent	adjacent	ADJ	JJ	Degree=Pos	_	_	_	_
24	promoter	promoter	NOUN	NN	Number=Sing	_	_	_	_
25	proximal	proximal	NOUN	NN	Number=Sing	_	_	_	_
26	AP	ap	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
27	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
28	1	1	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
29	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
30	binding	binding	VERB	VBG	VerbForm=Ger	_	_	_	_
31	site	site	NOUN	NN	Number=Sing	_	_	_	_
32	and	and	CCONJ	CC	_	_	_	_	_
33	this	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
34	hypothesis	hypothesis	NOUN	NN	Number=Sing	_	_	_	_
35	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
36	confirmed	confirm	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
37	here	here	ADV	RB	PronType=Dem	_	_	_	SpaceAfter=No
38	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1341
# text = Also in the current study, binding activity to the CD28RE/AP-1 sequence of the IL-2 promoter is evaluated.
1	Also	also	ADV	RB	_	_	_	_	_
2	in	in	ADP	IN	_	_	_	_	_
3	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
4	current	current	ADJ	JJ	Degree=Pos	_	_	_	_
5	study	study	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
6	,	,	PUNCT	,	_	_	_	_	_
7	binding	bind	VERB	VBG	VerbForm=Ger	_	_	_	_
8	activity	activity	NOUN	NN	Number=Sing	_	_	_	_
9	to	to	ADP	IN	_	_	_	_	_
10	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
11	CD28RE	Cd28re	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
12	/	/	PUNCT	,	_	_	_	_	SpaceAfter=No
13	AP	ap	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
14	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
15	1	1	NUM	CD	NumType=Card	_	_	_	_
16	sequence	sequence	NOUN	NN	Number=Sing	_	_	_	_
17	of	of	ADP	IN	_	_	_	_	_
18	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
19	IL	Il	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
20	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
21	2	2	NUM	CD	NumType=Card	_	_	_	_
22	promoter	promoter	NOUN	NN	Number=Sing	_	_	_	_
23	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
24	evaluated	evaluate	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	SpaceAfter=No
25	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1342
# text = Although four specific complexes can be detected binding to this sequence, only one of these complexes is specific for both the CD28RE and the adjacent AP-1 site.
1	Although	although	SCONJ	IN	_	_	_	_	_
2	four	four	NUM	CD	NumType=Card	_	_	_	_
3	specific	specific	ADJ	JJ	Degree=Pos	_	_	_	_
4	complexes	complexe	NOUN	NNS	Number=Plur	_	_	_	_
5	can	can	AUX	MD	VerbForm=Fin	_	_	_	_
6	be	be	AUX	VB	VerbForm=Inf	_	_	_	_
7	detected	detect	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
8	binding	bind	VERB	VBG	VerbForm=Ger	_	_	_	_
9	to	to	ADP	IN	_	_	_	_	_
10	this	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
11	sequence	sequence	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
12	,	,	PUNCT	,	_	_	_	_	_
13	only	only	ADV	RB	_	_	_	_	_
14	one	one	NUM	CD	NumType=Card	_	_	_	_
15	of	of	ADP	IN	_	_	_	_	_
16	these	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
17	complexes	complex	NOUN	NNS	Number=Plur	_	_	_	_
18	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
19	specific	specific	ADJ	JJ	Degree=Pos	_	_	_	_
20	for	for	ADP	IN	_	_	_	_	_
21	both	both	CCONJ	CC	_	_	_	_	_
22	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
23	CD28RE	Cd28re	NOUN	NN	Number=Sing	_	_	_	_
24	and	and	CCONJ	CC	_	_	_	_	_
25	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
26	adjacent	adjacent	ADJ	JJ	Degree=Pos	_	_	_	_
27	AP	ap	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
28	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
29	1	1	NUM	CD	NumType=Card	_	_	_	_
30	site	site	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
31	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1343
# text = Of the NF-kappaB/Rel family members tested, this CD28RE/AP-1-specific complex contains predominantly c-Rel, despite the fact that both p50 and RelA can efficiently bind to the CD28RE.
1	Of	of	ADP	IN	_	_	_	_	_
2	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
3	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
4	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
5	kappaB	kappaB	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
6	/	/	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
7	Rel	Rel	PROPN	NNP	Number=Sing	_	_	_	_
8	family	family	NOUN	NN	Number=Sing	_	_	_	_
9	members	member	NOUN	NNS	Number=Plur	_	_	_	_
10	tested	test	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	SpaceAfter=No
11	,	,	PUNCT	,	_	_	_	_	_
12	this	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
13	CD28RE	Cd28re	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
14	/	/	PUNCT	,	_	_	_	_	SpaceAfter=No
15	AP	ap	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
16	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
17	1	1	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
18	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
19	specific	specific	ADJ	JJ	Degree=Pos	_	_	_	_
20	complex	complex	NOUN	NN	Number=Sing	_	_	_	_
21	contains	contain	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
22	predominantly	predominantly	ADV	RB	_	_	_	_	_
23	c-	c-	SYM	NFP	_	_	_	_	SpaceAfter=No
24	Rel	Rel	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
25	,	,	PUNCT	,	_	_	_	_	_
26	despite	despite	ADP	IN	_	_	_	_	_
27	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
28	fact	fact	NOUN	NN	Number=Sing	_	_	_	_
29	that	that	SCONJ	IN	_	_	_	_	_
30	both	both	CCONJ	CC	_	_	_	_	_
31	p50	p50	NOUN	NN	Number=Sing	_	_	_	_
32	and	and	CCONJ	CC	_	_	_	_	_
33	RelA	Rela	NOUN	NN	Number=Sing	_	_	_	_
34	can	can	AUX	MD	VerbForm=Fin	_	_	_	_
35	efficiently	efficiently	ADV	RB	_	_	_	_	_
36	bind	bind	VERB	VB	VerbForm=Inf	_	_	_	_
37	to	to	ADP	IN	_	_	_	_	_
38	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
39	CD28RE	Cd28re	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
40	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1344
# text = c-Fos and c-Jun are also found in this CD28RE/AP-1-specific complex.
1	c	c	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
2	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
3	Fos	Fo	NOUN	NNS	Number=Plur	_	_	_	_
4	and	and	CCONJ	CC	_	_	_	_	_
5	c	c	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
6	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
7	Jun	Jun	PROPN	NNP	Number=Sing	_	_	_	_
8	are	be	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
9	also	also	ADV	RB	_	_	_	_	_
10	found	find	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
11	in	in	ADP	IN	_	_	_	_	_
12	this	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
13	CD28RE	Cd28re	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
14	/	/	PUNCT	,	_	_	_	_	SpaceAfter=No
15	AP	ap	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
16	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
17	1	1	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
18	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
19	specific	specific	ADJ	JJ	Degree=Pos	_	_	_	_
20	complex	complex	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
21	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1345
# text = These data indicate that functional complexes encompassing both the CD28RE and the AP-1-binding sites influence IL-2 promoter activity in CD28-costimulated T cells.
1	These	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
2	data	data	NOUN	NN	Number=Sing	_	_	_	_
3	indicate	indicate	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
4	that	that	SCONJ	IN	_	_	_	_	_
5	functional	functional	ADJ	JJ	Degree=Pos	_	_	_	_
6	complexes	complexe	NOUN	NNS	Number=Plur	_	_	_	_
7	encompassing	encompasse	VERB	VBG	VerbForm=Ger	_	_	_	_
8	both	both	CCONJ	CC	_	_	_	_	_
9	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
10	CD28RE	Cd28re	NOUN	NN	Number=Sing	_	_	_	_
11	and	and	CCONJ	CC	_	_	_	_	_
12	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
13	AP	ap	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
14	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
15	1	1	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
16	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
17	binding	binding	VERB	VBG	VerbForm=Ger	_	_	_	_
18	sites	site	NOUN	NNS	Number=Plur	_	_	_	_
19	influence	influence	NOUN	NN	Number=Sing	_	_	_	_
20	IL	Il	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
21	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
22	2	2	NUM	CD	NumType=Card	_	_	_	_
23	promoter	promoter	NOUN	NN	Number=Sing	_	_	_	_
24	activity	activity	NOUN	NN	Number=Sing	_	_	_	_
25	in	in	ADP	IN	_	_	_	_	_
26	CD28	CD28	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
27	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
28	costimulated	costimulate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
29	T	t	PROPN	NNP	Number=Sing	_	_	_	_
30	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
31	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 1346
# text = Document 003002482 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	003002482	003002482	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 1347
# text = Monocyte tethering by P-selectin regulates monocyte chemotactic protein-1 and tumor necrosis factor-alpha secretion.
1	Monocyte	Monocyte	PROPN	NNP	Number=Sing	_	_	_	_
2	tethering	tether	VERB	VBG	VerbForm=Ger	_	_	_	_
3	by	by	ADP	IN	_	_	_	_	_
4	P-	p-	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
5	selectin	selectin	NOUN	NN	Number=Sing	_	_	_	_
6	regulates	regulate	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
7	monocyte	monocyte	ADJ	JJ	Degree=Pos	_	_	_	_
8	chemotactic	chemotactic	ADJ	JJ	Degree=Pos	_	_	_	_
9	protein	protein	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
10	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
11	1	1	NUM	CD	NumType=Card	_	_	_	_
12	and	and	CCONJ	CC	_	_	_	_	_
13	tumor	tumor	NOUN	NN	Number=Sing	_	_	_	_
14	necrosis	necrosis	NOUN	NN	Number=Sing	_	_	_	_
15	factor	factor	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
16	-alpha	-alpha	NOUN	NN	Number=Sing	_	_	_	_
17	secretion	secretion	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
18	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1348
# text = Signal integration and NF-kappa B translocation [see comments]
1	Signal	signal	ADJ	JJ	Degree=Pos	_	_	_	_
2	integration	integration	NOUN	NN	Number=Sing	_	_	_	_
3	and	and	CCONJ	CC	_	_	_	_	_
4	NF	Nf	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
5	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
6	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_
7	B	b	NOUN	NN	Number=Sing	_	_	_	_
8	translocation	translocation	NOUN	NN	Number=Sing	_	_	_	_
9	[	[	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
10	see	see	VERB	VB	Mood=Imp|VerbForm=Fin	_	_	_	_
11	comments	comment	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
12	]	]	PUNCT	-RRB-	_	_	_	_	SpacesAfter=\s\n

# sent_id = 1349
# text = Adhesion molecules that tether circulating leukocytes to endothelial cells may also transduce or modulate outside-in signals for cellular activation, providing an initial regulatory point in the inflammatory response.
1	Adhesion	Adhesion	NOUN	NN	Number=Sing	_	_	_	_
2	molecules	molecule	NOUN	NNS	Number=Plur	_	_	_	_
3	that	that	SCONJ	IN	_	_	_	_	_
4	tether	tether	SCONJ	IN	_	_	_	_	_
5	circulating	circulate	VERB	VBG	VerbForm=Ger	_	_	_	_
6	leukocytes	leukocyte	NOUN	NNS	Number=Plur	_	_	_	_
7	to	to	ADP	IN	_	_	_	_	_
8	endothelial	endothelial	ADJ	JJ	Degree=Pos	_	_	_	_
9	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
10	may	may	AUX	MD	VerbForm=Fin	_	_	_	_
11	also	also	ADV	RB	_	_	_	_	_
12	transduce	transduce	VERB	VB	VerbForm=Inf	_	_	_	_
13	or	or	CCONJ	CC	_	_	_	_	_
14	modulate	modulate	VERB	VB	VerbForm=Inf	_	_	_	_
15	outside	outside	ADV	RB	_	_	_	_	SpaceAfter=No
16	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
17	in	in	ADP	IN	_	_	_	_	_
18	signals	signal	NOUN	NNS	Number=Plur	_	_	_	_
19	for	for	ADP	IN	_	_	_	_	_
20	cellular	cellular	ADJ	JJ	Degree=Pos	_	_	_	_
21	activation	activation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
22	,	,	PUNCT	,	_	_	_	_	_
23	providing	provide	VERB	VBG	VerbForm=Ger	_	_	_	_
24	an	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
25	initial	initial	ADJ	JJ	Degree=Pos	_	_	_	_
26	regulatory	regulatory	ADJ	JJ	Degree=Pos	_	_	_	_
27	point	point	NOUN	NN	Number=Sing	_	_	_	_
28	in	in	ADP	IN	_	_	_	_	_
29	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
30	inflammatory	inflammatory	ADJ	JJ	Degree=Pos	_	_	_	_
31	response	response	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
32	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1350
# text = Adhesion of human monocytes to P-selectin, the most rapidly expressed endothelial tethering factor, increased the secretion of monocyte chemotactic protein-1 (MCP-1) and tumor necrosis factor-alpha (TNF-alpha) by the leukocytes when they were stimulated with platelet-activating factor.
1	Adhesion	Adhesion	NOUN	NN	Number=Sing	_	_	_	_
2	of	of	ADP	IN	_	_	_	_	_
3	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
4	monocytes	monocyte	NOUN	NNS	Number=Plur	_	_	_	_
5	to	to	ADP	IN	_	_	_	_	_
6	P-	P-	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
7	selectin	selectin	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
8	,	,	PUNCT	,	_	_	_	_	_
9	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
10	most	most	ADV	RBS	_	_	_	_	_
11	rapidly	rapidly	ADV	RB	_	_	_	_	_
12	expressed	express	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
13	endothelial	endothelial	ADJ	JJ	Degree=Pos	_	_	_	_
14	tethering	tethering	NOUN	NN	Number=Sing	_	_	_	_
15	factor	factor	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
16	,	,	PUNCT	,	_	_	_	_	_
17	increased	increase	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
18	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
19	secretion	secretion	NOUN	NN	Number=Sing	_	_	_	_
20	of	of	ADP	IN	_	_	_	_	_
21	monocyte	monocyte	ADJ	JJ	Degree=Pos	_	_	_	_
22	chemotactic	chemotactic	ADJ	JJ	Degree=Pos	_	_	_	_
23	protein	protein	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
24	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
25	1	1	NUM	CD	NumType=Card	_	_	_	_
26	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
27	MCP	Mcp	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
28	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
29	1	1	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
30	)	)	PUNCT	-RRB-	_	_	_	_	_
31	and	and	CCONJ	CC	_	_	_	_	_
32	tumor	tumor	NOUN	NN	Number=Sing	_	_	_	_
33	necrosis	necrosis	NOUN	NN	Number=Sing	_	_	_	_
34	factor	factor	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
35	-alpha	-alpha	NOUN	NN	Number=Sing	_	_	_	_
36	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
37	TNF	Tnf	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
38	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
39	alpha	alpha	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
40	)	)	PUNCT	-RRB-	_	_	_	_	_
41	by	by	ADP	IN	_	_	_	_	_
42	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
43	leukocytes	leukocyte	NOUN	NNS	Number=Plur	_	_	_	_
44	when	when	ADV	WRB	PronType=Int	_	_	_	_
45	they	they	PRON	PRP	Case=Nom|Number=Plur|Person=3|PronType=Prs	_	_	_	_
46	were	be	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
47	stimulated	stimulate	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
48	with	with	ADP	IN	_	_	_	_	_
49	platelet	platelet	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
50	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
51	activating	activate	VERB	VBG	VerbForm=Ger	_	_	_	_
52	factor	factor	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
53	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1351
# text = Increased cytokine secretion was specifically inhibited by G1, an anti-P-selectin mAb that prevents P-selectin from binding to its ligand (P-selectin glycoprotein ligand-1) on myeloid cells.
1	Increased	increase	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
2	cytokine	cytokine	PRON	PRP	_	_	_	_	_
3	secretion	secretion	NOUN	NN	Number=Sing	_	_	_	_
4	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
5	specifically	specifically	ADV	RB	_	_	_	_	_
6	inhibited	inhibit	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
7	by	by	ADP	IN	_	_	_	_	_
8	G1	G1	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
9	,	,	PUNCT	,	_	_	_	_	_
10	an	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
11	anti-P-	anti-P-	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
12	selectin	selectin	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
13	mAb	mAb	PROPN	NNP	Number=Sing	_	_	_	_
14	that	that	PRON	WDT	PronType=Rel	_	_	_	_
15	prevents	prevent	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
16	P-	P-	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
17	selectin	selectin	NOUN	NN	Number=Sing	_	_	_	_
18	from	from	SCONJ	IN	_	_	_	_	_
19	binding	bind	VERB	VBG	VerbForm=Ger	_	_	_	_
20	to	to	ADP	IN	_	_	_	_	_
21	its	its	PRON	PRP$	Gender=Neut|Number=Sing|Person=3|Poss=Yes|PronType=Prs	_	_	_	_
22	ligand	ligand	NOUN	NN	Number=Sing	_	_	_	_
23	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
24	P-	p-	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
25	selectin	selectin	NOUN	NN	Number=Sing	_	_	_	_
26	glycoprotein	glycoprotein	NOUN	NN	Number=Sing	_	_	_	_
27	ligand	ligand	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
28	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
29	1	1	X	LS	_	_	_	_	SpaceAfter=No
30	)	)	PUNCT	-RRB-	_	_	_	_	_
31	on	on	ADP	IN	_	_	_	_	_
32	myeloid	myeloid	ADJ	JJ	Degree=Pos	_	_	_	_
33	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
34	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1352
# text = Moreover, tethering by P-selectin specifically enhanced nuclear translocation of nuclear factor-kappa B (NF-kappa B), a transcription factor required for expression of MCP-1, TNF-alpha, and other immediate-early genes.
1	Moreover	moreover	ADV	RB	_	_	_	_	SpaceAfter=No
2	,	,	PUNCT	,	_	_	_	_	_
3	tethering	tether	VERB	VBG	VerbForm=Ger	_	_	_	_
4	by	by	ADP	IN	_	_	_	_	_
5	P-	p-	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
6	selectin	selectin	NOUN	NN	Number=Sing	_	_	_	_
7	specifically	specifically	ADV	RB	_	_	_	_	_
8	enhanced	enhance	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
9	nuclear	nuclear	ADJ	JJ	Degree=Pos	_	_	_	_
10	translocation	translocation	NOUN	NN	Number=Sing	_	_	_	_
11	of	of	ADP	IN	_	_	_	_	_
12	nuclear	nuclear	ADJ	JJ	Degree=Pos	_	_	_	_
13	factor	factor	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
14	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
15	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_
16	B	b	NOUN	NN	Number=Sing	_	_	_	_
17	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
18	NF	Nf	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
19	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
20	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_
21	B	b	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
22	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
23	,	,	PUNCT	,	_	_	_	_	_
24	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
25	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
26	factor	factor	NOUN	NN	Number=Sing	_	_	_	_
27	required	require	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
28	for	for	ADP	IN	_	_	_	_	_
29	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
30	of	of	ADP	IN	_	_	_	_	_
31	MCP	MCP	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
32	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
33	1	1	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
34	,	,	PUNCT	,	_	_	_	_	_
35	TNF	Tnf	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
36	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
37	alpha	alpha	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
38	,	,	PUNCT	,	_	_	_	_	_
39	and	and	CCONJ	CC	_	_	_	_	_
40	other	other	ADJ	JJ	Degree=Pos	_	_	_	_
41	immediate	immediate	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
42	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
43	early	early	ADJ	JJ	Degree=Pos	_	_	_	_
44	genes	gene	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
45	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1353
# text = These results demonstrate that P-selectin, through its ligands on monocytes, may locally regulate cytokine secretion in inflamed tissues.
1	These	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
2	results	result	NOUN	NNS	Number=Plur	_	_	_	_
3	demonstrate	demonstrate	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
4	that	that	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
5	P-	p-	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
6	selectin	selectin	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
7	,	,	PUNCT	,	_	_	_	_	_
8	through	through	ADP	IN	_	_	_	_	_
9	its	its	PRON	PRP$	Gender=Neut|Number=Sing|Person=3|Poss=Yes|PronType=Prs	_	_	_	_
10	ligands	ligand	NOUN	NNS	Number=Plur	_	_	_	_
11	on	on	ADP	IN	_	_	_	_	_
12	monocytes	monocyte	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
13	,	,	PUNCT	,	_	_	_	_	_
14	may	may	AUX	MD	VerbForm=Fin	_	_	_	_
15	locally	locally	ADV	RB	_	_	_	_	_
16	regulate	regulate	VERB	VB	VerbForm=Inf	_	_	_	_
17	cytokine	cytokine	NOUN	NN	Number=Sing	_	_	_	_
18	secretion	secretion	NOUN	NN	Number=Sing	_	_	_	_
19	in	in	ADP	IN	_	_	_	_	_
20	inflamed	inflam	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
21	tissues	tissue	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
22	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 1354
# text = Document 003002487 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	003002487	003002487	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 1355
# text = Role of cellular tumor necrosis factor receptor-associated factors in NF-kappaB activation and lymphocyte transformation by herpesvirus Saimiri STP.
1	Role	role	NOUN	NN	Number=Sing	_	_	_	_
2	of	of	ADP	IN	_	_	_	_	_
3	cellular	cellular	ADJ	JJ	Degree=Pos	_	_	_	_
4	tumor	tumor	NOUN	NN	Number=Sing	_	_	_	_
5	necrosis	necrosis	NOUN	NN	Number=Sing	_	_	_	_
6	factor	factor	NOUN	NN	Number=Sing	_	_	_	_
7	receptor	receptor	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
8	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
9	associated	associate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
10	factors	factor	NOUN	NNS	Number=Plur	_	_	_	_
11	in	in	ADP	IN	_	_	_	_	_
12	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
13	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
14	kappaB	kappaB	PROPN	NNP	Number=Sing	_	_	_	_
15	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
16	and	and	CCONJ	CC	_	_	_	_	_
17	lymphocyte	lymphocyte	NOUN	NN	Number=Sing	_	_	_	_
18	transformation	transformation	NOUN	NN	Number=Sing	_	_	_	_
19	by	by	ADP	IN	_	_	_	_	_
20	herpesvirus	herpesvirus	NOUN	NN	Number=Sing	_	_	_	_
21	Saimiri	Saimiri	PROPN	NNP	Number=Sing	_	_	_	_
22	STP	STP	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
23	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 1356
# text = The STP oncoproteins of the herpesvirus saimiri (HVS) subgroup A strain 11 and subgroup C strain 488 are now found to be stably associated with tumor necrosis factor receptor-associated factor (TRAF) 1, 2, or 3.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	STP	sTp	NOUN	NN	Number=Sing	_	_	_	_
3	oncoproteins	oncoprotein	NOUN	NNS	Number=Plur	_	_	_	_
4	of	of	ADP	IN	_	_	_	_	_
5	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
6	herpesvirus	herpesvirus	NOUN	NN	Number=Sing	_	_	_	_
7	saimiri	saimiri	NOUN	NN	Number=Sing	_	_	_	_
8	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
9	HVS	HVS	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
10	)	)	PUNCT	-RRB-	_	_	_	_	_
11	subgroup	subgroup	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
12	A	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
13	strain	strain	NOUN	NN	Number=Sing	_	_	_	_
14	11	11	NUM	CD	NumType=Card	_	_	_	_
15	and	and	CCONJ	CC	_	_	_	_	_
16	subgroup	subgroup	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
17	C	C	PROPN	NNP	Number=Sing	_	_	_	_
18	strain	strain	NOUN	NN	Number=Sing	_	_	_	_
19	488	488	NUM	CD	NumType=Card	_	_	_	_
20	are	be	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
21	now	now	ADV	RB	_	_	_	_	_
22	found	find	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
23	to	to	PART	TO	_	_	_	_	_
24	be	be	AUX	VB	VerbForm=Inf	_	_	_	_
25	stably	stably	ADV	RB	_	_	_	_	_
26	associated	associate	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
27	with	with	ADP	IN	_	_	_	_	_
28	tumor	tumor	NOUN	NN	Number=Sing	_	_	_	_
29	necrosis	necrosis	NOUN	NN	Number=Sing	_	_	_	_
30	factor	factor	NOUN	NN	Number=Sing	_	_	_	_
31	receptor	receptor	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
32	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
33	associated	associate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
34	factor	factor	NOUN	NN	Number=Sing	_	_	_	_
35	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
36	TRAF	TRAF	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
37	)	)	PUNCT	-RRB-	_	_	_	_	_
38	1	1	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
39	,	,	PUNCT	,	_	_	_	_	_
40	2	2	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
41	,	,	PUNCT	,	_	_	_	_	_
42	or	or	CCONJ	CC	_	_	_	_	_
43	3	3	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
44	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1357
# text = Mutational analyses identified residues of PXQXT/S in STP-A11 as critical for TRAF association.
1	Mutational	Mutational	ADJ	JJ	Degree=Pos	_	_	_	_
2	analyses	analysis	NOUN	NNS	Number=Plur	_	_	_	_
3	identified	identify	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
4	residues	residue	NOUN	NNS	Number=Plur	_	_	_	_
5	of	of	ADP	IN	_	_	_	_	_
6	PXQXT/	PXQXT/	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
7	S	s	NOUN	NNS	Number=Plur	_	_	_	_
8	in	in	ADP	IN	_	_	_	_	_
9	STP	STP	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
10	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
11	A11	A11	PROPN	NNP	Number=Sing	_	_	_	_
12	as	as	ADP	IN	_	_	_	_	_
13	critical	critical	ADJ	JJ	Degree=Pos	_	_	_	_
14	for	for	ADP	IN	_	_	_	_	_
15	TRAF	Traf	PROPN	NNP	Number=Sing	_	_	_	_
16	association	association	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
17	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1358
# text = In addition, a somewhat divergent region of STP-C488 is critical for TRAF association.
1	In	in	ADP	IN	_	_	_	_	_
2	addition	addition	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
3	,	,	PUNCT	,	_	_	_	_	_
4	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
5	somewhat	somewhat	ADV	RB	_	_	_	_	_
6	divergent	divergent	ADJ	JJ	Degree=Pos	_	_	_	_
7	region	region	NOUN	NN	Number=Sing	_	_	_	_
8	of	of	ADP	IN	_	_	_	_	_
9	STP-	Stp-	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
10	C488	c488	NOUN	NN	Number=Sing	_	_	_	_
11	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
12	critical	critical	ADJ	JJ	Degree=Pos	_	_	_	_
13	for	for	ADP	IN	_	_	_	_	_
14	TRAF	Traf	NOUN	NN	Number=Sing	_	_	_	_
15	association	association	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
16	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1359
# text = Mutational analysis also revealed that STP-C488 induced NF-kappaB activation that was correlated with its ability to associate with TRAFs.
1	Mutational	Mutational	ADJ	JJ	Degree=Pos	_	_	_	_
2	analysis	analysis	NOUN	NN	Number=Sing	_	_	_	_
3	also	also	ADV	RB	_	_	_	_	_
4	revealed	reveal	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
5	that	that	SCONJ	IN	_	_	_	_	_
6	STP-C488	STP-C488	PROPN	NNP	Number=Sing	_	_	_	_
7	induced	induce	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
8	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
9	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
10	kappaB	kappaB	PROPN	NNP	Number=Sing	_	_	_	_
11	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
12	that	that	PRON	WDT	PronType=Rel	_	_	_	_
13	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
14	correlated	correlate	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
15	with	with	ADP	IN	_	_	_	_	_
16	its	its	PRON	PRP$	Gender=Neut|Number=Sing|Person=3|Poss=Yes|PronType=Prs	_	_	_	_
17	ability	ability	NOUN	NN	Number=Sing	_	_	_	_
18	to	to	PART	TO	_	_	_	_	_
19	associate	associate	VERB	VB	VerbForm=Inf	_	_	_	_
20	with	with	ADP	IN	_	_	_	_	_
21	TRAFs	Trafs	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
22	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1360
# text = The HVS STP-C488 P10-->R mutant was deficient in human T-lymphocyte transformation to interleukin-2-independent growth but showed wild-type phenotype for marmoset T-lymphocyte transformation in vitro and in vivo.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	HVS	HVS	PROPN	NNP	Number=Sing	_	_	_	_
3	STP-C488	STP-C488	PROPN	NNP	Number=Sing	_	_	_	_
4	P10-->	P10-->	PUNCT	,	_	_	_	_	SpaceAfter=No
5	R	R	PROPN	NNP	Number=Sing	_	_	_	_
6	mutant	mutant	NOUN	NN	Number=Sing	_	_	_	_
7	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
8	deficient	deficient	ADJ	JJ	Degree=Pos	_	_	_	_
9	in	in	ADP	IN	_	_	_	_	_
10	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
11	T-	T-	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
12	lymphocyte	lymphocyte	NOUN	NN	Number=Sing	_	_	_	_
13	transformation	transformation	NOUN	NN	Number=Sing	_	_	_	_
14	to	to	PART	TO	_	_	_	_	_
15	interleukin	interleukin	VERB	VB	VerbForm=Inf	_	_	_	SpaceAfter=No
16	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
17	2	2	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
18	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
19	independent	independent	ADJ	JJ	Degree=Pos	_	_	_	_
20	growth	growth	NOUN	NN	Number=Sing	_	_	_	_
21	but	but	CCONJ	CC	_	_	_	_	_
22	showed	show	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
23	wild	wild	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
24	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
25	type	type	NOUN	NN	Number=Sing	_	_	_	_
26	phenotype	phenotype	NOUN	NN	Number=Sing	_	_	_	_
27	for	for	ADP	IN	_	_	_	_	_
28	marmoset	marmoset	NOUN	NN	Number=Sing	_	_	_	_
29	T-	T-	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
30	lymphocyte	lymphocyte	NOUN	NN	Number=Sing	_	_	_	_
31	transformation	transformation	NOUN	NN	Number=Sing	_	_	_	_
32	in	in	ADP	IN	_	_	_	_	_
33	vitro	vitro	NOUN	NN	Number=Sing	_	_	_	_
34	and	and	CCONJ	CC	_	_	_	_	_
35	in	in	ADP	IN	_	_	_	_	_
36	vivo	vivo	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
37	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1361
# text = The STP-C488 P10-->R mutant was also defective in Rat-1 fibroblast transformation, and fibroblast cell transformation was blocked by a TRAF2 dominant-negative mutant.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	STP-C488	Stp-c488	NUM	CD	NumType=Card	_	_	_	_
3	P10-->	P10-->	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
4	R	R	PROPN	NNP	Number=Sing	_	_	_	_
5	mutant	mutant	PROPN	NNP	Number=Sing	_	_	_	_
6	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
7	also	also	ADV	RB	_	_	_	_	_
8	defective	defective	ADJ	JJ	Degree=Pos	_	_	_	_
9	in	in	ADP	IN	_	_	_	_	_
10	Rat	Rat	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
11	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
12	1	1	NUM	CD	NumType=Card	_	_	_	_
13	fibroblast	fibroblast	NOUN	NN	Number=Sing	_	_	_	_
14	transformation	transformation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
15	,	,	PUNCT	,	_	_	_	_	_
16	and	and	CCONJ	CC	_	_	_	_	_
17	fibroblast	fibroblast	ADJ	JJ	Degree=Pos	_	_	_	_
18	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
19	transformation	transformation	NOUN	NN	Number=Sing	_	_	_	_
20	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
21	blocked	block	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
22	by	by	ADP	IN	_	_	_	_	_
23	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
24	TRAF2	TRAF2	NUM	CD	NumType=Card	_	_	_	_
25	dominant	dominant	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
26	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
27	negative	negative	ADJ	JJ	Degree=Pos	_	_	_	_
28	mutant	mutant	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
29	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1362
# text = These data implicate TRAFs in STP-C488-mediated transformation of human lymphocytes and rodent fibroblasts.
1	These	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
2	data	data	NOUN	NN	Number=Sing	_	_	_	_
3	implicate	implicate	ADJ	JJ	Degree=Pos	_	_	_	_
4	TRAFs	TRAF	NOUN	NNS	Number=Plur	_	_	_	_
5	in	in	ADP	IN	_	_	_	_	_
6	STP-C488	STP-C488	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
7	-	-	PUNCT	:	_	_	_	_	SpaceAfter=No
8	mediated	mediate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
9	transformation	transformation	NOUN	NN	Number=Sing	_	_	_	_
10	of	of	ADP	IN	_	_	_	_	_
11	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
12	lymphocytes	lymphocyte	NOUN	NNS	Number=Plur	_	_	_	_
13	and	and	CCONJ	CC	_	_	_	_	_
14	rodent	rodent	ADJ	JJ	Degree=Pos	_	_	_	_
15	fibroblasts	fibroblast	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
16	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1363
# text = Other factors are implicated in immortalization of common marmoset T lymphocytes and may also be critical in the transformation of human lymphocytes and rodent fibroblasts.
1	Other	other	ADJ	JJ	Degree=Pos	_	_	_	_
2	factors	factor	NOUN	NNS	Number=Plur	_	_	_	_
3	are	be	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
4	implicated	implicate	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
5	in	in	ADP	IN	_	_	_	_	_
6	immortalization	immortalization	NOUN	NN	Number=Sing	_	_	_	_
7	of	of	ADP	IN	_	_	_	_	_
8	common	common	ADJ	JJ	Degree=Pos	_	_	_	_
9	marmoset	marmoset	NOUN	NN	Number=Sing	_	_	_	_
10	T	t	PROPN	NNP	Number=Sing	_	_	_	_
11	lymphocytes	lymphocyte	NOUN	NNS	Number=Plur	_	_	_	_
12	and	and	CCONJ	CC	_	_	_	_	_
13	may	may	AUX	MD	VerbForm=Fin	_	_	_	_
14	also	also	ADV	RB	_	_	_	_	_
15	be	be	AUX	VB	VerbForm=Inf	_	_	_	_
16	critical	critical	ADJ	JJ	Degree=Pos	_	_	_	_
17	in	in	ADP	IN	_	_	_	_	_
18	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
19	transformation	transformation	NOUN	NN	Number=Sing	_	_	_	_
20	of	of	ADP	IN	_	_	_	_	_
21	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
22	lymphocytes	lymphocyte	NOUN	NNS	Number=Plur	_	_	_	_
23	and	and	CCONJ	CC	_	_	_	_	_
24	rodent	rodent	ADJ	JJ	Degree=Pos	_	_	_	_
25	fibroblasts	fibroblast	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
26	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 1364
# text = Document 003002488 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	003002488	003002488	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 1365
# text = Signal transduction abnormalities in T lymphocytes from patients with advanced renal carcinoma: clinical relevance and effects of cytokine therapy.
1	Signal	signal	ADJ	JJ	Degree=Pos	_	_	_	_
2	transduction	transduction	NOUN	NN	Number=Sing	_	_	_	_
3	abnormalities	abnormality	NOUN	NNS	Number=Plur	_	_	_	_
4	in	in	ADP	IN	_	_	_	_	_
5	T	T	PROPN	NNP	Number=Sing	_	_	_	_
6	lymphocytes	lymphocyte	NOUN	NNS	Number=Plur	_	_	_	_
7	from	from	ADP	IN	_	_	_	_	_
8	patients	patient	NOUN	NNS	Number=Plur	_	_	_	_
9	with	with	ADP	IN	_	_	_	_	_
10	advanced	advanced	ADJ	JJ	Degree=Pos	_	_	_	_
11	renal	renal	ADJ	JJ	Degree=Pos	_	_	_	_
12	carcinoma	carcinoma	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
13	:	:	PUNCT	:	_	_	_	_	_
14	clinical	clinical	ADJ	JJ	Degree=Pos	_	_	_	_
15	relevance	relevance	NOUN	NN	Number=Sing	_	_	_	_
16	and	and	CCONJ	CC	_	_	_	_	_
17	effects	effect	NOUN	NNS	Number=Plur	_	_	_	_
18	of	of	ADP	IN	_	_	_	_	_
19	cytokine	cytokine	NOUN	NN	Number=Sing	_	_	_	_
20	therapy	therapy	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
21	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 1366
# text = Studies have demonstrated abnormalities of the CD3/T-cell antigen receptor (TCR) and pathways of signal transduction in T lymphocytes from animals and patients with advanced malignancy.
1	Studies	study	NOUN	NNS	Number=Plur	_	_	_	_
2	have	have	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
3	demonstrated	demonstrate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
4	abnormalities	abnormality	NOUN	NNS	Number=Plur	_	_	_	_
5	of	of	ADP	IN	_	_	_	_	_
6	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
7	CD3/T-	Cd3/t-	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
8	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
9	antigen	antigen	NOUN	NN	Number=Sing	_	_	_	_
10	receptor	receptor	NOUN	NN	Number=Sing	_	_	_	_
11	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
12	TCR	TCR	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
13	)	)	PUNCT	-RRB-	_	_	_	_	_
14	and	and	CCONJ	CC	_	_	_	_	_
15	pathways	pathway	NOUN	NNS	Number=Plur	_	_	_	_
16	of	of	ADP	IN	_	_	_	_	_
17	signal	signal	NOUN	NN	Number=Sing	_	_	_	_
18	transduction	transduction	NOUN	NN	Number=Sing	_	_	_	_
19	in	in	ADP	IN	_	_	_	_	_
20	T	t	PROPN	NNP	Number=Sing	_	_	_	_
21	lymphocytes	lymphocyte	NOUN	NNS	Number=Plur	_	_	_	_
22	from	from	ADP	IN	_	_	_	_	_
23	animals	animal	NOUN	NNS	Number=Plur	_	_	_	_
24	and	and	CCONJ	CC	_	_	_	_	_
25	patients	patient	NOUN	NNS	Number=Plur	_	_	_	_
26	with	with	ADP	IN	_	_	_	_	_
27	advanced	advanced	ADJ	JJ	Degree=Pos	_	_	_	_
28	malignancy	malignancy	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
29	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1367
# text = Diminished expression of TCRzeta and p56(lck) that are associated with the TCR and reduced nuclear localization of RelA containing nuclear factor kappaB (NFkappaB) complexes have been noted.
1	Diminished	Diminished	ADJ	JJ	Degree=Pos	_	_	_	_
2	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
3	of	of	ADP	IN	_	_	_	_	_
4	TCRzeta	TCRzeta	PROPN	NNP	Number=Sing	_	_	_	_
5	and	and	CCONJ	CC	_	_	_	_	_
6	p56	p56	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
7	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
8	lck	lck	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
9	)	)	PUNCT	-RRB-	_	_	_	_	_
10	that	that	PRON	WDT	PronType=Rel	_	_	_	_
11	are	be	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
12	associated	associate	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
13	with	with	ADP	IN	_	_	_	_	_
14	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
15	TCR	Tcr	NOUN	NN	Number=Sing	_	_	_	_
16	and	and	CCONJ	CC	_	_	_	_	_
17	reduced	reduce	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
18	nuclear	nuclear	ADJ	JJ	Degree=Pos	_	_	_	_
19	localization	localization	NOUN	NN	Number=Sing	_	_	_	_
20	of	of	ADP	IN	_	_	_	_	_
21	RelA	RelA	PROPN	NNP	Number=Sing	_	_	_	_
22	containing	contain	VERB	VBG	VerbForm=Ger	_	_	_	_
23	nuclear	nuclear	ADJ	JJ	Degree=Pos	_	_	_	_
24	factor	factor	NOUN	NN	Number=Sing	_	_	_	_
25	kappaB	kappaB	PROPN	NNP	Number=Sing	_	_	_	_
26	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
27	NFkappaB	NFkappaB	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
28	)	)	PUNCT	-RRB-	_	_	_	_	_
29	complexes	complex	NOUN	NNS	Number=Plur	_	_	_	_
30	have	have	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
31	been	be	AUX	VBN	Tense=Past|VerbForm=Part	_	_	_	_
32	noted	note	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	SpaceAfter=No
33	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1368
# text = These defects have been described in T cells from patients with malignant melanoma, renal cell carcinoma (RCC), ovarian cancer, and colorectal cancer.
1	These	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
2	defects	defects	NOUN	NNS	Number=Plur	_	_	_	_
3	have	have	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
4	been	be	AUX	VBN	Tense=Past|VerbForm=Part	_	_	_	_
5	described	describe	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
6	in	in	ADP	IN	_	_	_	_	_
7	T	t	PROPN	NNP	Number=Sing	_	_	_	_
8	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
9	from	from	ADP	IN	_	_	_	_	_
10	patients	patient	NOUN	NN	Number=Sing	_	_	_	_
11	with	with	ADP	IN	_	_	_	_	_
12	malignant	malignant	ADJ	JJ	Degree=Pos	_	_	_	_
13	melanoma	melanoma	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
14	,	,	PUNCT	,	_	_	_	_	_
15	renal	renal	ADJ	JJ	Degree=Pos	_	_	_	_
16	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
17	carcinoma	carcinoma	NOUN	NN	Number=Sing	_	_	_	_
18	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
19	RCC	RCC	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
20	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
21	,	,	PUNCT	,	_	_	_	_	_
22	ovarian	ovarian	ADJ	JJ	Degree=Pos	_	_	_	_
23	cancer	cancer	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
24	,	,	PUNCT	,	_	_	_	_	_
25	and	and	CCONJ	CC	_	_	_	_	_
26	colorectal	colorectal	ADJ	JJ	Degree=Pos	_	_	_	_
27	cancer	cancer	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
28	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1369
# text = Preliminary observations also indicate possible correlation with clinical variables such as stage in selected instances.
1	Preliminary	Preliminary	ADJ	JJ	Degree=Pos	_	_	_	_
2	observations	observation	NOUN	NNS	Number=Plur	_	_	_	_
3	also	also	ADV	RB	_	_	_	_	_
4	indicate	indicate	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
5	possible	possible	ADJ	JJ	Degree=Pos	_	_	_	_
6	correlation	correlation	NOUN	NN	Number=Sing	_	_	_	_
7	with	with	ADP	IN	_	_	_	_	_
8	clinical	clinical	ADJ	JJ	Degree=Pos	_	_	_	_
9	variables	variable	NOUN	NNS	Number=Plur	_	_	_	_
10	such	such	ADJ	JJ	Degree=Pos	_	_	_	_
11	as	as	ADP	IN	_	_	_	_	_
12	stage	stage	NOUN	NN	Number=Sing	_	_	_	_
13	in	in	ADP	IN	_	_	_	_	_
14	selected	selected	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
15	instances	instance	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
16	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1370
# text = To further characterize altered expression of TCRzeta, p56(lck), and impaired activation of NFkappaB, T lymphocytes were obtained from 65 patients with RCC, the majority of whom were receiving combination cytokine therapy [interleukin (IL)-2, IFN alpha-containing regimens] and 37 control individuals.
1	To	to	ADP	IN	_	_	_	_	_
2	further	further	ADJ	JJ	Degree=Pos	_	_	_	_
3	characterize	characterize	NOUN	NN	Number=Sing	_	_	_	_
4	altered	alter	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
5	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
6	of	of	ADP	IN	_	_	_	_	_
7	TCRzeta	TCRzeta	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
8	,	,	PUNCT	,	_	_	_	_	_
9	p56	p56	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
10	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
11	lck	lck	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
12	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
13	,	,	PUNCT	,	_	_	_	_	_
14	and	and	CCONJ	CC	_	_	_	_	_
15	impaired	impaire	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
16	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
17	of	of	ADP	IN	_	_	_	_	_
18	NFkappaB	NFkappaB	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
19	,	,	PUNCT	,	_	_	_	_	_
20	T	t	PROPN	NNP	Number=Sing	_	_	_	_
21	lymphocytes	lymphocyte	NOUN	NNS	Number=Plur	_	_	_	_
22	were	be	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
23	obtained	obtain	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
24	from	from	ADP	IN	_	_	_	_	_
25	65	65	NUM	CD	NumType=Card	_	_	_	_
26	patients	patient	NOUN	NN	Number=Sing	_	_	_	_
27	with	with	ADP	IN	_	_	_	_	_
28	RCC	RCC	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
29	,	,	PUNCT	,	_	_	_	_	_
30	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
31	majority	majority	NOUN	NN	Number=Sing	_	_	_	_
32	of	of	ADP	IN	_	_	_	_	_
33	whom	whom	PRON	WP	PronType=Rel	_	_	_	_
34	were	be	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
35	receiving	receive	VERB	VBG	Tense=Pres|VerbForm=Part	_	_	_	_
36	combination	combination	NOUN	NN	Number=Sing	_	_	_	_
37	cytokine	cytokine	NOUN	NN	Number=Sing	_	_	_	_
38	therapy	therapy	NOUN	NN	Number=Sing	_	_	_	_
39	[	[	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
40	interleukin	interleukin	NOUN	NN	Number=Sing	_	_	_	_
41	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
42	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
43	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
44	-	-	SYM	SYM	_	_	_	_	SpaceAfter=No
45	2	2	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
46	,	,	PUNCT	,	_	_	_	_	_
47	IFN	Ifn	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
48	alpha	alpha	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
49	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
50	containing	contain	VERB	VBG	VerbForm=Ger	_	_	_	_
51	regimens	regimen	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
52	]	]	PUNCT	-RRB-	_	_	_	_	_
53	and	and	CCONJ	CC	_	_	_	_	_
54	37	37	NUM	CD	NumType=Card	_	_	_	_
55	control	control	NOUN	NN	Number=Sing	_	_	_	_
56	individuals	individual	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
57	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1371
# text = In 29 of these patients, levels of TCRzeta and p56(lck) were determined by Western blots of T-cell lysates and semiquantitated using densitometry.
1	In	in	ADP	IN	_	_	_	_	_
2	29	29	NUM	CD	NumType=Card	_	_	_	_
3	of	of	ADP	IN	_	_	_	_	_
4	these	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
5	patients	patient	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
6	,	,	PUNCT	,	_	_	_	_	_
7	levels	level	NOUN	NNS	Number=Plur	_	_	_	_
8	of	of	ADP	IN	_	_	_	_	_
9	TCRzeta	TCRzeta	PROPN	NNP	Number=Sing	_	_	_	_
10	and	and	CCONJ	CC	_	_	_	_	_
11	p56	p56	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
12	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
13	lck	lck	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
14	)	)	PUNCT	-RRB-	_	_	_	_	_
15	were	be	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
16	determined	determine	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
17	by	by	ADP	IN	_	_	_	_	_
18	Western	western	ADJ	JJ	Degree=Pos	_	_	_	_
19	blots	blot	NOUN	NNS	Number=Plur	_	_	_	_
20	of	of	ADP	IN	_	_	_	_	_
21	T-	t-	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
22	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
23	lysates	lysate	NOUN	NNS	Number=Plur	_	_	_	_
24	and	and	CCONJ	CC	_	_	_	_	_
25	semiquantitated	semiquantitate	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
26	using	use	VERB	VBG	VerbForm=Ger	_	_	_	_
27	densitometry	densitometry	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
28	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1372
# text = Relative levels were then correlated with a series of clinical variables including response to therapy, performance status, survival, disease sites, age, and others.
1	Relative	relative	ADJ	JJ	Degree=Pos	_	_	_	_
2	levels	level	NOUN	NNS	Number=Plur	_	_	_	_
3	were	be	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
4	then	then	ADV	RB	PronType=Dem	_	_	_	_
5	correlated	correlate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
6	with	with	ADP	IN	_	_	_	_	_
7	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
8	series	series	NOUN	NN	Number=Sing	_	_	_	_
9	of	of	ADP	IN	_	_	_	_	_
10	clinical	clinical	ADJ	JJ	Degree=Pos	_	_	_	_
11	variables	variable	NOUN	NNS	Number=Plur	_	_	_	_
12	including	include	VERB	VBG	VerbForm=Ger	_	_	_	_
13	response	response	NOUN	NN	Number=Sing	_	_	_	_
14	to	to	ADP	IN	_	_	_	_	_
15	therapy	therapy	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
16	,	,	PUNCT	,	_	_	_	_	_
17	performance	performance	NOUN	NN	Number=Sing	_	_	_	_
18	status	status	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
19	,	,	PUNCT	,	_	_	_	_	_
20	survival	survival	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
21	,	,	PUNCT	,	_	_	_	_	_
22	disease	disease	NOUN	NN	Number=Sing	_	_	_	_
23	sites	site	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
24	,	,	PUNCT	,	_	_	_	_	_
25	age	age	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
26	,	,	PUNCT	,	_	_	_	_	_
27	and	and	CCONJ	CC	_	_	_	_	_
28	others	other	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
29	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1373
# text = In another group of 28 patients (three individuals from the first group), the frequency of abnormal NFkappaB activation was studied using electrophoretic mobility shift assays after activation of T cells with phorbol myristate acetate/ionomycin or anti-CD3 monoclonal antibody.
1	In	in	ADP	IN	_	_	_	_	_
2	another	another	DET	DT	_	_	_	_	_
3	group	group	NOUN	NN	Number=Sing	_	_	_	_
4	of	of	ADP	IN	_	_	_	_	_
5	28	28	NUM	CD	NumType=Card	_	_	_	_
6	patients	patient	NOUN	NN	Number=Sing	_	_	_	_
7	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
8	three	three	NUM	CD	NumType=Card	_	_	_	_
9	individuals	individual	NOUN	NNS	Number=Plur	_	_	_	_
10	from	from	ADP	IN	_	_	_	_	_
11	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
12	first	first	ADJ	JJ	Degree=Pos|NumType=Ord	_	_	_	_
13	group	group	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
14	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
15	,	,	PUNCT	,	_	_	_	_	_
16	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
17	frequency	frequency	NOUN	NN	Number=Sing	_	_	_	_
18	of	of	ADP	IN	_	_	_	_	_
19	abnormal	abnormal	ADJ	JJ	Degree=Pos	_	_	_	_
20	NFkappaB	NFkappaB	PROPN	NNP	Number=Sing	_	_	_	_
21	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
22	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
23	studied	study	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
24	using	use	VERB	VBG	VerbForm=Ger	_	_	_	_
25	electrophoretic	electrophoretic	ADJ	JJ	Degree=Pos	_	_	_	_
26	mobility	mobility	NOUN	NN	Number=Sing	_	_	_	_
27	shift	shift	NOUN	NN	Number=Sing	_	_	_	_
28	assays	assays	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
29	after	after	ADP	IN	_	_	_	_	_
30	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
31	of	of	ADP	IN	_	_	_	_	_
32	T	t	PROPN	NNP	Number=Sing	_	_	_	_
33	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
34	with	with	ADP	IN	_	_	_	_	_
35	phorbol	phorbol	NOUN	NN	Number=Sing	_	_	_	_
36	myristate	myristate	NOUN	NN	Number=Sing	_	_	_	_
37	acetate	acetate	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
38	/	/	PUNCT	,	_	_	_	_	SpaceAfter=No
39	ionomycin	ionomycin	NOUN	NN	Number=Sing	_	_	_	_
40	or	or	CCONJ	CC	_	_	_	_	_
41	anti-CD3	anti-CD3	NUM	CD	NumType=Card	_	_	_	_
42	monoclonal	monoclonal	ADJ	JJ	Degree=Pos	_	_	_	_
43	antibody	antibody	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
44	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1374
# text = Changes in these signaling molecules during cytokine treatment were also investigated.
1	Changes	change	NOUN	NNS	Number=Plur	_	_	_	_
2	in	in	ADP	IN	_	_	_	_	_
3	these	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
4	signaling	signaling	NOUN	NN	Number=Sing	_	_	_	_
5	molecules	molecule	NOUN	NNS	Number=Plur	_	_	_	_
6	during	during	ADP	IN	_	_	_	_	_
7	cytokine	cytokine	NOUN	NN	Number=Sing	_	_	_	_
8	treatment	treatment	NOUN	NN	Number=Sing	_	_	_	_
9	were	be	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
10	also	also	ADV	RB	_	_	_	_	_
11	investigated	investigate	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	SpaceAfter=No
12	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1375
# text = TCRzeta and p56(lck) were detected in the peripheral blood T cells in 27 of 29 patients, and overall, reduced levels were noted visually in 12 of 29 (41%) and 13 of 29 (45%) individuals, respectively.
1	TCRzeta	TCRzeta	PROPN	NNP	Number=Sing	_	_	_	_
2	and	and	CCONJ	CC	_	_	_	_	_
3	p56	p56	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
4	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
5	lck	lck	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
6	)	)	PUNCT	-RRB-	_	_	_	_	_
7	were	be	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
8	detected	detect	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
9	in	in	ADP	IN	_	_	_	_	_
10	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
11	peripheral	peripheral	ADJ	JJ	Degree=Pos	_	_	_	_
12	blood	blood	NOUN	NN	Number=Sing	_	_	_	_
13	T	t	NUM	CD	NumType=Card	_	_	_	_
14	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
15	in	in	ADP	IN	_	_	_	_	_
16	27	27	NUM	CD	NumType=Card	_	_	_	_
17	of	of	ADP	IN	_	_	_	_	_
18	29	29	NUM	CD	NumType=Card	_	_	_	_
19	patients	patient	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
20	,	,	PUNCT	,	_	_	_	_	_
21	and	and	CCONJ	CC	_	_	_	_	_
22	overall	overall	ADV	RB	_	_	_	_	SpaceAfter=No
23	,	,	PUNCT	,	_	_	_	_	_
24	reduced	reduce	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
25	levels	level	NOUN	NNS	Number=Plur	_	_	_	_
26	were	be	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
27	noted	note	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
28	visually	visually	ADV	RB	_	_	_	_	_
29	in	in	ADP	IN	_	_	_	_	_
30	12	12	NUM	CD	NumType=Card	_	_	_	_
31	of	of	ADP	IN	_	_	_	_	_
32	29	29	NUM	CD	NumType=Card	_	_	_	_
33	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
34	41	41	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
35	%	%	SYM	NN	Number=Sing	_	_	_	SpaceAfter=No
36	)	)	PUNCT	-RRB-	_	_	_	_	_
37	and	and	CCONJ	CC	_	_	_	_	_
38	13	13	NUM	CD	NumType=Card	_	_	_	_
39	of	of	ADP	IN	_	_	_	_	_
40	29	29	NUM	CD	NumType=Card	_	_	_	_
41	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
42	45	45	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
43	%	%	SYM	NN	Number=Sing	_	_	_	SpaceAfter=No
44	)	)	PUNCT	-RRB-	_	_	_	_	_
45	individuals	individual	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
46	,	,	PUNCT	,	_	_	_	_	_
47	respectively	respectively	ADV	RB	_	_	_	_	SpaceAfter=No
48	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1376
# text = When levels were semiquantitated using densitometry, significant decreases of TCRzeta (P = 0.029) and p56(lck) (P = 0.029) but not CD3epsilon (P = 0.131), compared with control levels, were found.
1	When	when	ADV	WRB	PronType=Int	_	_	_	_
2	levels	level	NOUN	NNS	Number=Plur	_	_	_	_
3	were	be	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
4	semiquantitated	semiquantitate	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
5	using	use	VERB	VBG	VerbForm=Ger	_	_	_	_
6	densitometry	densitometry	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
7	,	,	PUNCT	,	_	_	_	_	_
8	significant	significant	ADJ	JJ	Degree=Pos	_	_	_	_
9	decreases	decrease	NOUN	NNS	Number=Plur	_	_	_	_
10	of	of	ADP	IN	_	_	_	_	_
11	TCRzeta	TCRzeta	PROPN	NNP	Number=Sing	_	_	_	_
12	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
13	P	P	SYM	NFP	_	_	_	_	_
14	=	=	SYM	SYM	_	_	_	_	_
15	0.029	0.029	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
16	)	)	PUNCT	-RRB-	_	_	_	_	_
17	and	and	CCONJ	CC	_	_	_	_	_
18	p56	p56	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
19	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
20	lck	lck	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
21	)	)	PUNCT	-RRB-	_	_	_	_	_
22	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
23	P	p	NOUN	NN	Number=Sing	_	_	_	_
24	=	=	SYM	SYM	_	_	_	_	_
25	0.029	0.029	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
26	)	)	PUNCT	-RRB-	_	_	_	_	_
27	but	but	CCONJ	CC	_	_	_	_	_
28	not	not	ADV	RB	_	_	_	_	_
29	CD3epsilon	CD3epsilon	PROPN	NNP	Number=Sing	_	_	_	_
30	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
31	P	P	SYM	NFP	_	_	_	_	_
32	=	=	SYM	SYM	_	_	_	_	_
33	0.131	0.131	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
34	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
35	,	,	PUNCT	,	_	_	_	_	_
36	compared	compare	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
37	with	with	ADP	IN	_	_	_	_	_
38	control	control	NOUN	NN	Number=Sing	_	_	_	_
39	levels	level	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
40	,	,	PUNCT	,	_	_	_	_	_
41	were	be	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
42	found	find	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	SpaceAfter=No
43	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1377
# text = In patients treated with IL-2/IFN alpha-based therapy, relative levels of TCRzeta increased significantly (P = 0.002) on day 15 of cycle one compared with the baseline.
1	In	in	ADP	IN	_	_	_	_	_
2	patients	patient	NOUN	NNS	Number=Plur	_	_	_	_
3	treated	treat	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
4	with	with	ADP	IN	_	_	_	_	_
5	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
6	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
7	2	2	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
8	/	/	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
9	IFN	Ifn	NOUN	NN	Number=Sing	_	_	_	_
10	alpha	alpha	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
11	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
12	based	base	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
13	therapy	therapy	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
14	,	,	PUNCT	,	_	_	_	_	_
15	relative	relative	ADJ	JJ	Degree=Pos	_	_	_	_
16	levels	level	NOUN	NNS	Number=Plur	_	_	_	_
17	of	of	ADP	IN	_	_	_	_	_
18	TCRzeta	TCRzeta	PROPN	NNP	Number=Sing	_	_	_	_
19	increased	increase	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
20	significantly	significantly	ADV	RB	_	_	_	_	_
21	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
22	P	p	SYM	NFP	_	_	_	_	_
23	=	=	SYM	SYM	_	_	_	_	_
24	0.002	0.002	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
25	)	)	PUNCT	-RRB-	_	_	_	_	_
26	on	on	ADP	IN	_	_	_	_	_
27	day	day	NOUN	NN	Number=Sing	_	_	_	_
28	15	15	NUM	CD	NumType=Card	_	_	_	_
29	of	of	ADP	IN	_	_	_	_	_
30	cycle	cycle	NOUN	NN	Number=Sing	_	_	_	_
31	one	one	NUM	CD	NumType=Card	_	_	_	_
32	compared	compare	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
33	with	with	ADP	IN	_	_	_	_	_
34	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
35	baseline	baseline	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
36	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1378
# text = Correlations of TCRzeta or p56(lck) levels with response or disease variables, except for lower TCRzeta levels (P < 0.001) in the presence of bone metastases, were not found.
1	Correlations	Correlation	NOUN	NNS	Number=Plur	_	_	_	_
2	of	of	ADP	IN	_	_	_	_	_
3	TCRzeta	TCRzeta	PROPN	NNP	Number=Sing	_	_	_	_
4	or	or	CCONJ	CC	_	_	_	_	_
5	p56	p56	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
6	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
7	lck	lck	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
8	)	)	PUNCT	-RRB-	_	_	_	_	_
9	levels	level	NOUN	NNS	Number=Plur	_	_	_	_
10	with	with	ADP	IN	_	_	_	_	_
11	response	response	NOUN	NN	Number=Sing	_	_	_	_
12	or	or	CCONJ	CC	_	_	_	_	_
13	disease	disease	NOUN	NN	Number=Sing	_	_	_	_
14	variables	variable	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
15	,	,	PUNCT	,	_	_	_	_	_
16	except	except	ADP	IN	_	_	_	_	_
17	for	for	ADP	IN	_	_	_	_	_
18	lower	lower	ADJ	JJR	Degree=Cmp	_	_	_	_
19	TCRzeta	TCRzeta	PROPN	NNP	Number=Sing	_	_	_	_
20	levels	level	NOUN	NNS	Number=Plur	_	_	_	_
21	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
22	P	p	NOUN	NN	Number=Sing	_	_	_	_
23	<	<	PUNCT	-LRB-	_	_	_	_	_
24	0.001	0.001	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
25	)	)	PUNCT	-RRB-	_	_	_	_	_
26	in	in	ADP	IN	_	_	_	_	_
27	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
28	presence	presence	NOUN	NN	Number=Sing	_	_	_	_
29	of	of	ADP	IN	_	_	_	_	_
30	bone	bone	NOUN	NN	Number=Sing	_	_	_	_
31	metastases	metastase	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
32	,	,	PUNCT	,	_	_	_	_	_
33	were	be	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
34	not	not	PART	RB	_	_	_	_	_
35	found	find	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	SpaceAfter=No
36	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1379
# text = Abnormal NFkappaB activation after stimulation with phorbol myristate acetate/ionomycin and/or anti-CD3 monoclonal antibody was found in 59% of patients (17 of 28) and was not accounted for by the advanced age of the study cohort.
1	Abnormal	abnormal	PROPN	NNP	Number=Sing	_	_	_	_
2	NFkappaB	NFkappaB	PROPN	NNP	Number=Sing	_	_	_	_
3	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
4	after	after	ADP	IN	_	_	_	_	_
5	stimulation	stimulation	NOUN	NN	Number=Sing	_	_	_	_
6	with	with	ADP	IN	_	_	_	_	_
7	phorbol	phorbol	NOUN	NN	Number=Sing	_	_	_	_
8	myristate	myristate	NOUN	NN	Number=Sing	_	_	_	_
9	acetate	acetate	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
10	/ionomycin	/ionomycin	NOUN	NN	Number=Sing	_	_	_	_
11	and	and	CCONJ	CC	_	_	_	_	SpaceAfter=No
12	/	/	PUNCT	,	_	_	_	_	SpaceAfter=No
13	or	or	CCONJ	CC	_	_	_	_	_
14	anti-CD3	anti-CD3	NUM	CD	NumType=Card	_	_	_	_
15	monoclonal	monoclonal	ADJ	JJ	Degree=Pos	_	_	_	_
16	antibody	antibody	NOUN	NN	Number=Sing	_	_	_	_
17	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
18	found	find	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
19	in	in	ADP	IN	_	_	_	_	_
20	59	59	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
21	%	%	SYM	NN	Number=Sing	_	_	_	_
22	of	of	ADP	IN	_	_	_	_	_
23	patients	patient	NOUN	NNS	Number=Plur	_	_	_	_
24	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
25	17	17	NUM	CD	NumType=Card	_	_	_	_
26	of	of	ADP	IN	_	_	_	_	_
27	28	28	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
28	)	)	PUNCT	-RRB-	_	_	_	_	_
29	and	and	CCONJ	CC	_	_	_	_	_
30	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
31	not	not	PART	RB	_	_	_	_	_
32	accounted	account	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
33	for	for	ADP	IN	_	_	_	_	_
34	by	by	ADP	IN	_	_	_	_	_
35	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
36	advanced	advanced	ADJ	JJ	Degree=Pos	_	_	_	_
37	age	age	NOUN	NN	Number=Sing	_	_	_	_
38	of	of	ADP	IN	_	_	_	_	_
39	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
40	study	study	NOUN	NN	Number=Sing	_	_	_	_
41	cohort	cohort	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
42	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1380
# text = Activation of NFkappaB in peripheral blood T cells was inducible during cytokine therapy in four of six individuals who displayed impaired NFkappaB activity prior to therapy.
1	Activation	Activation	NOUN	NN	Number=Sing	_	_	_	_
2	of	of	ADP	IN	_	_	_	_	_
3	NFkappaB	NFkappaB	PROPN	NNP	Number=Sing	_	_	_	_
4	in	in	ADP	IN	_	_	_	_	_
5	peripheral	peripheral	ADJ	JJ	Degree=Pos	_	_	_	_
6	blood	blood	NOUN	NN	Number=Sing	_	_	_	_
7	T	t	PROPN	NNP	Number=Sing	_	_	_	_
8	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
9	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
10	inducible	inducible	ADJ	JJ	Degree=Pos	_	_	_	_
11	during	during	ADP	IN	_	_	_	_	_
12	cytokine	cytokine	NOUN	NN	Number=Sing	_	_	_	_
13	therapy	therapy	NOUN	NN	Number=Sing	_	_	_	_
14	in	in	ADP	IN	_	_	_	_	_
15	four	four	NUM	CD	NumType=Card	_	_	_	_
16	of	of	ADP	IN	_	_	_	_	_
17	six	six	NUM	CD	NumType=Card	_	_	_	_
18	individuals	individual	NOUN	NNS	Number=Plur	_	_	_	_
19	who	who	PRON	WP	PronType=Rel	_	_	_	_
20	displayed	display	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
21	impaired	impaire	ADJ	JJ	Degree=Pos	_	_	_	_
22	NFkappaB	NFkappaB	PROPN	NNP	Number=Sing	_	_	_	_
23	activity	activity	NOUN	NN	Number=Sing	_	_	_	_
24	prior	prior	ADJ	JJ	Degree=Pos	_	_	_	_
25	to	to	ADP	IN	_	_	_	_	_
26	therapy	therapy	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
27	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1381
# text = Moreover, impaired activation of NFkappaB does not appear linked to a reduction of TCRzeta expression, because in five patients, normal TCRzeta levels were present although kappaB binding was not inducible.
1	Moreover	moreover	ADV	RB	_	_	_	_	SpaceAfter=No
2	,	,	PUNCT	,	_	_	_	_	_
3	impaired	impaired	ADJ	JJ	Degree=Pos	_	_	_	_
4	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
5	of	of	ADP	IN	_	_	_	_	_
6	NFkappaB	NFkappaB	PROPN	NNP	Number=Sing	_	_	_	_
7	does	do	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
8	not	not	PART	RB	_	_	_	_	_
9	appear	appear	VERB	VB	VerbForm=Inf	_	_	_	_
10	linked	link	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
11	to	to	ADP	IN	_	_	_	_	_
12	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
13	reduction	reduction	NOUN	NN	Number=Sing	_	_	_	_
14	of	of	ADP	IN	_	_	_	_	_
15	TCRzeta	TCRzeta	PROPN	NNP	Number=Sing	_	_	_	_
16	expression	expression	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
17	,	,	PUNCT	,	_	_	_	_	_
18	because	because	SCONJ	IN	_	_	_	_	_
19	in	in	ADP	IN	_	_	_	_	_
20	five	five	NUM	CD	NumType=Card	_	_	_	_
21	patients	patient	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
22	,	,	PUNCT	,	_	_	_	_	_
23	normal	normal	ADJ	JJ	Degree=Pos	_	_	_	_
24	TCRzeta	TCRzeta	PROPN	NNP	Number=Sing	_	_	_	_
25	levels	level	NOUN	NNS	Number=Plur	_	_	_	_
26	were	be	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
27	present	present	ADJ	JJ	Degree=Pos	_	_	_	_
28	although	although	SCONJ	IN	_	_	_	_	_
29	kappaB	kappaB	PROPN	NNP	Number=Sing	_	_	_	_
30	binding	binding	VERB	VBG	VerbForm=Ger	_	_	_	_
31	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
32	not	not	PART	RB	_	_	_	_	_
33	inducible	inducible	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
34	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1382
# text = In the majority of patients with advanced RCC, peripheral blood T cells express TCRzeta and p56(lck), and in a subset, reduced levels of these TCRzeta associated molecules are seen that may increase during cytokine-based therapy.
1	In	in	ADP	IN	_	_	_	_	_
2	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
3	majority	majority	NOUN	NN	Number=Sing	_	_	_	_
4	of	of	ADP	IN	_	_	_	_	_
5	patients	patient	NOUN	NNS	Number=Plur	_	_	_	_
6	with	with	ADP	IN	_	_	_	_	_
7	advanced	advanced	ADJ	JJ	Degree=Pos	_	_	_	_
8	RCC	RCC	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
9	,	,	PUNCT	,	_	_	_	_	_
10	peripheral	peripheral	ADJ	JJ	Degree=Pos	_	_	_	_
11	blood	blood	NOUN	NN	Number=Sing	_	_	_	_
12	T	t	PROPN	NNP	Number=Sing	_	_	_	_
13	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
14	express	express	VERB	VB	VerbForm=Inf	_	_	_	_
15	TCRzeta	TCRzeta	PROPN	NNP	Number=Sing	_	_	_	_
16	and	and	CCONJ	CC	_	_	_	_	_
17	p56	p56	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
18	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
19	lck	lck	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
20	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
21	,	,	PUNCT	,	_	_	_	_	_
22	and	and	CCONJ	CC	_	_	_	_	_
23	in	in	ADP	IN	_	_	_	_	_
24	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
25	subset	subset	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
26	,	,	PUNCT	,	_	_	_	_	_
27	reduced	reduce	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
28	levels	level	NOUN	NNS	Number=Plur	_	_	_	_
29	of	of	ADP	IN	_	_	_	_	_
30	these	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
31	TCRzeta	TCRzeta	PROPN	NNP	Number=Sing	_	_	_	_
32	associated	associate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
33	molecules	molecule	NOUN	NNS	Number=Plur	_	_	_	_
34	are	be	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
35	seen	see	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
36	that	that	PRON	WDT	PronType=Dem	_	_	_	_
37	may	may	AUX	MD	VerbForm=Fin	_	_	_	_
38	increase	increase	VERB	VB	VerbForm=Inf	_	_	_	_
39	during	during	ADP	IN	_	_	_	_	_
40	cytokine	cytokine	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
41	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
42	based	base	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
43	therapy	therapy	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
44	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1383
# text = Abnormal activation of NFkappaB is also present in >50% of patients and may also revert to normal during IL-2/IFN alpha-based treatment.
1	Abnormal	abnormal	ADJ	JJ	Degree=Pos	_	_	_	_
2	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
3	of	of	ADP	IN	_	_	_	_	_
4	NFkappaB	NFkappaB	PROPN	NNP	Number=Sing	_	_	_	_
5	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
6	also	also	ADV	RB	_	_	_	_	_
7	present	presend	ADJ	JJ	Degree=Pos	_	_	_	_
8	in	in	ADP	IN	_	_	_	_	_
9	>	>	SYM	NFP	_	_	_	_	SpaceAfter=No
10	50	50	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
11	%	%	SYM	NN	Number=Sing	_	_	_	_
12	of	of	ADP	IN	_	_	_	_	_
13	patients	patient	NOUN	NNS	Number=Plur	_	_	_	_
14	and	and	CCONJ	CC	_	_	_	_	_
15	may	may	AUX	MD	VerbForm=Fin	_	_	_	_
16	also	also	ADV	RB	_	_	_	_	_
17	revert	revert	VERB	VB	VerbForm=Inf	_	_	_	_
18	to	to	PART	TO	_	_	_	_	_
19	normal	normal	VERB	VB	VerbForm=Inf	_	_	_	_
20	during	during	ADP	IN	_	_	_	_	_
21	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
22	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
23	2	2	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
24	/	/	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
25	IFN	Ifn	NOUN	NN	Number=Sing	_	_	_	_
26	alpha	alpha	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
27	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
28	based	base	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
29	treatment	treatment	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
30	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1384
# text = This alteration in NFkappaB activation occurred in the presence of normal expression of TCRzeta-associated signaling elements.
1	This	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
2	alteration	alteration	NOUN	NN	Number=Sing	_	_	_	_
3	in	in	ADP	IN	_	_	_	_	_
4	NFkappaB	NFkappaB	PROPN	NNP	Number=Sing	_	_	_	_
5	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
6	occurred	occur	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
7	in	in	ADP	IN	_	_	_	_	_
8	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
9	presence	presence	NOUN	NN	Number=Sing	_	_	_	_
10	of	of	ADP	IN	_	_	_	_	_
11	normal	normal	ADJ	JJ	Degree=Pos	_	_	_	_
12	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
13	of	of	ADP	IN	_	_	_	_	_
14	TCRzeta	TCRzeta	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
15	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
16	associated	associate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
17	signaling	signaling	NOUN	NN	Number=Sing	_	_	_	_
18	elements	element	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
19	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1385
# text = The clinical significance of these findings remains unclear.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	clinical	clinical	ADJ	JJ	Degree=Pos	_	_	_	_
3	significance	significance	NOUN	NN	Number=Sing	_	_	_	_
4	of	of	ADP	IN	_	_	_	_	_
5	these	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
6	findings	finding	NOUN	NNS	Number=Plur	_	_	_	_
7	remains	remain	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
8	unclear	unclear	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
9	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 1386
# text = Document 003002493 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	003002493	003002493	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 1387
# text = Activation of protein kinase C and elevation of cAMP interact synergistically to raise c-Fos and AP-1 activity in Jurkat cells.
1	Activation	Activation	NOUN	NN	Number=Sing	_	_	_	_
2	of	of	ADP	IN	_	_	_	_	_
3	protein	protein	NOUN	NN	Number=Sing	_	_	_	_
4	kinase	kinase	NOUN	NN	Number=Sing	_	_	_	_
5	C	c	NOUN	NN	Number=Sing	_	_	_	_
6	and	and	CCONJ	CC	_	_	_	_	_
7	elevation	elevation	NOUN	NN	Number=Sing	_	_	_	_
8	of	of	ADP	IN	_	_	_	_	_
9	cAMP	camp	NOUN	NN	Number=Sing	_	_	_	_
10	interact	interact	NOUN	NN	Number=Sing	_	_	_	_
11	synergistically	synergistically	ADV	RB	_	_	_	_	_
12	to	to	PART	TO	_	_	_	_	_
13	raise	raise	VERB	VB	VerbForm=Inf	_	_	_	_
14	c	c	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
15	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
16	Fos	Fo	NOUN	NNS	Number=Plur	_	_	_	_
17	and	and	CCONJ	CC	_	_	_	_	_
18	AP	ap	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
19	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
20	1	1	NUM	CD	NumType=Card	_	_	_	_
21	activity	activity	NOUN	NN	Number=Sing	_	_	_	_
22	in	in	ADP	IN	_	_	_	_	_
23	Jurkat	Jurkat	PROPN	NNP	Number=Sing	_	_	_	_
24	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
25	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 1388
# text = We have earlier found that in Jurkat cells activation of protein kinase C (PKC) enhances the cyclic adenosine monophosphate (cAMP) accumulation induced by adenosine receptor stimulation or activation of Gs.
1	We	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
2	have	have	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
3	earlier	earlier	ADV	RB	_	_	_	_	_
4	found	find	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
5	that	that	SCONJ	IN	_	_	_	_	_
6	in	in	ADP	IN	_	_	_	_	_
7	Jurkat	Jurkat	PROPN	NNP	Number=Sing	_	_	_	_
8	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
9	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
10	of	of	ADP	IN	_	_	_	_	_
11	protein	protein	NOUN	NN	Number=Sing	_	_	_	_
12	kinase	kinase	NOUN	NN	Number=Sing	_	_	_	_
13	C	C	PROPN	NNP	Number=Sing	_	_	_	_
14	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
15	PKC	PKC	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
16	)	)	PUNCT	-RRB-	_	_	_	_	_
17	enhances	enhance	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
18	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
19	cyclic	cyclic	ADJ	JJ	Degree=Pos	_	_	_	_
20	adenosine	adenosine	NOUN	NN	Number=Sing	_	_	_	_
21	monophosphate	monophosphate	NOUN	NN	Number=Sing	_	_	_	_
22	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
23	cAMP	camp	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
24	)	)	PUNCT	-RRB-	_	_	_	_	_
25	accumulation	accumulation	NOUN	NN	Number=Sing	_	_	_	_
26	induced	induce	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
27	by	by	ADP	IN	_	_	_	_	_
28	adenosine	adenosine	NOUN	NN	Number=Sing	_	_	_	_
29	receptor	receptor	NOUN	NN	Number=Sing	_	_	_	_
30	stimulation	stimulation	NOUN	NN	Number=Sing	_	_	_	_
31	or	or	CCONJ	CC	_	_	_	_	_
32	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
33	of	of	ADP	IN	_	_	_	_	_
34	Gs	g	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
35	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1389
# text = Here we have therefore examined the effect of the phorbol ester PMA (phorbol 12-myristate 13-acetate) which stimulates PKC and a combination of the adenosine receptor agonist NECA (5'-(N-ethyl)-carboxamido adenosine) and forskolin to raise cAMP, on the levels of c-Fos and Jun and on the binding and transcriptional activity of the transcription factor, activator protein-1 (AP-1).
1	Here	here	ADV	RB	PronType=Dem	_	_	_	_
2	we	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
3	have	have	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
4	therefore	therefore	ADV	RB	_	_	_	_	_
5	examined	examine	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
6	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
7	effect	effect	NOUN	NN	Number=Sing	_	_	_	_
8	of	of	ADP	IN	_	_	_	_	_
9	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
10	phorbol	phorbol	NOUN	NN	Number=Sing	_	_	_	_
11	ester	ester	NOUN	NN	Number=Sing	_	_	_	_
12	PMA	PMA	PROPN	NNP	Number=Sing	_	_	_	_
13	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
14	phorbol	phorbol	NOUN	NN	Number=Sing	_	_	_	_
15	12	12	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
16	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
17	myristate	myristate	NOUN	NN	Number=Sing	_	_	_	_
18	13	13	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
19	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
20	acetate	acetate	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
21	)	)	PUNCT	-RRB-	_	_	_	_	_
22	which	which	PRON	WDT	PronType=Rel	_	_	_	_
23	stimulates	stimulate	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
24	PKC	PKC	PROPN	NNP	Number=Sing	_	_	_	_
25	and	and	CCONJ	CC	_	_	_	_	_
26	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
27	combination	combination	NOUN	NN	Number=Sing	_	_	_	_
28	of	of	ADP	IN	_	_	_	_	_
29	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
30	adenosine	adenosine	ADJ	JJ	Degree=Pos	_	_	_	_
31	receptor	receptor	NOUN	NN	Number=Sing	_	_	_	_
32	agonist	agonist	NOUN	NN	Number=Sing	_	_	_	_
33	NECA	NECA	PROPN	NNP	Number=Sing	_	_	_	_
34	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
35	5	5	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
36	'-(	'-(	PUNCT	.	_	_	_	_	SpaceAfter=No
37	N-	N-	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
38	ethyl	ethyl	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
39	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
40	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
41	carboxamido	carboxamido	NOUN	NN	Number=Sing	_	_	_	_
42	adenosine	adenosine	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
43	)	)	PUNCT	-RRB-	_	_	_	_	_
44	and	and	CCONJ	CC	_	_	_	_	_
45	forskolin	forskolin	VERB	VB	VerbForm=Inf	_	_	_	_
46	to	to	PART	TO	_	_	_	_	_
47	raise	raise	VERB	VB	VerbForm=Inf	_	_	_	_
48	cAMP	camp	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
49	,	,	PUNCT	,	_	_	_	_	_
50	on	on	ADP	IN	_	_	_	_	_
51	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
52	levels	level	NOUN	NNS	Number=Plur	_	_	_	_
53	of	of	ADP	IN	_	_	_	_	_
54	c	c	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
55	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
56	Fos	Fo	PROPN	NNP	Number=Sing	_	_	_	_
57	and	and	CCONJ	CC	_	_	_	_	_
58	Jun	Jun	PROPN	NNP	Number=Sing	_	_	_	_
59	and	and	CCONJ	CC	_	_	_	_	_
60	on	on	ADP	IN	_	_	_	_	_
61	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
62	binding	binding	NOUN	NN	Number=Sing	_	_	_	_
63	and	and	CCONJ	CC	_	_	_	_	_
64	transcriptional	transcriptional	ADJ	JJ	Degree=Pos	_	_	_	_
65	activity	activity	NOUN	NN	Number=Sing	_	_	_	_
66	of	of	ADP	IN	_	_	_	_	_
67	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
68	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
69	factor	factor	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
70	,	,	PUNCT	,	_	_	_	_	_
71	activator	activator	NOUN	NN	Number=Sing	_	_	_	_
72	protein	protein	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
73	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
74	1	1	NUM	CD	NumType=Card	_	_	_	_
75	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
76	AP	ap	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
77	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
78	1	1	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
79	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
80	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1390
# text = PMA treatment caused a concentration- and time-dependent increase in both c-Fos and Jun immunoreactivity in contrast to cAMP elevation that had only a slight effect.
1	PMA	PMA	PROPN	NNP	Number=Sing	_	_	_	_
2	treatment	treatment	NOUN	NN	Number=Sing	_	_	_	_
3	caused	cause	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
4	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
5	concentration	concentration	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
6	-	-	PUNCT	,	_	_	_	_	_
7	and	and	CCONJ	CC	_	_	_	_	_
8	time	time	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
9	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
10	dependent	dependent	ADJ	JJ	Degree=Pos	_	_	_	_
11	increase	increase	NOUN	NN	Number=Sing	_	_	_	_
12	in	in	ADP	IN	_	_	_	_	_
13	both	both	CCONJ	CC	_	_	_	_	_
14	c-	c-	SYM	SYM	_	_	_	_	SpaceAfter=No
15	Fos	Fos	PROPN	NNPS	Number=Plur	_	_	_	_
16	and	and	CCONJ	CC	_	_	_	_	_
17	Jun	Jun	PROPN	NNP	Number=Sing	_	_	_	_
18	immunoreactivity	immunoreactivity	NOUN	NN	Number=Sing	_	_	_	_
19	in	in	ADP	IN	_	_	_	_	_
20	contrast	contrast	ADJ	JJ	Degree=Pos	_	_	_	_
21	to	to	PART	TO	_	_	_	_	_
22	cAMP	camp	VERB	VB	VerbForm=Inf	_	_	_	_
23	elevation	elevation	NOUN	NN	Number=Sing	_	_	_	_
24	that	that	PRON	WDT	PronType=Rel	_	_	_	_
25	had	have	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
26	only	only	ADV	RB	_	_	_	_	_
27	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
28	slight	slight	ADJ	JJ	Degree=Pos	_	_	_	_
29	effect	effect	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
30	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1391
# text = Both PMA and the combination of NECA and forskolin acted together either to increase (c-Fos) or decrease (Jun) protein levels as well as increasing AP-1 binding, as judged by gel-shift assay, and AP-1 transcriptional activity.
1	Both	both	CCONJ	CC	_	_	_	_	_
2	PMA	PMA	PROPN	NNP	Number=Sing	_	_	_	_
3	and	and	CCONJ	CC	_	_	_	_	_
4	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
5	combination	combination	NOUN	NN	Number=Sing	_	_	_	_
6	of	of	ADP	IN	_	_	_	_	_
7	NECA	NECA	PROPN	NNP	Number=Sing	_	_	_	_
8	and	and	CCONJ	CC	_	_	_	_	_
9	forskolin	forskolin	PROPN	NNP	Number=Sing	_	_	_	_
10	acted	act	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
11	together	together	ADV	RB	_	_	_	_	_
12	either	either	CCONJ	CC	_	_	_	_	_
13	to	to	ADP	IN	_	_	_	_	_
14	increase	increase	NOUN	NN	Number=Sing	_	_	_	_
15	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
16	c	c	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
17	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
18	Fos	Fos	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
19	)	)	PUNCT	-RRB-	_	_	_	_	_
20	or	or	CCONJ	CC	_	_	_	_	_
21	decrease	decrease	NOUN	NN	Number=Sing	_	_	_	_
22	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
23	Jun	Jun	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
24	)	)	PUNCT	-RRB-	_	_	_	_	_
25	protein	protein	NOUN	NN	Number=Sing	_	_	_	_
26	levels	level	NOUN	NNS	Number=Plur	_	_	_	_
27	as	as	ADV	RB	_	_	_	_	_
28	well	well	ADV	RB	Degree=Pos	_	_	_	_
29	as	as	SCONJ	IN	_	_	_	_	_
30	increasing	increase	VERB	VBG	VerbForm=Ger	_	_	_	_
31	AP	ap	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
32	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
33	1	1	NUM	CD	NumType=Card	_	_	_	_
34	binding	binding	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
35	,	,	PUNCT	,	_	_	_	_	_
36	as	as	SCONJ	IN	_	_	_	_	_
37	judged	judge	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
38	by	by	ADP	IN	_	_	_	_	_
39	gel	gel	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
40	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
41	shift	shift	NOUN	NN	Number=Sing	_	_	_	_
42	assay	assay	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
43	,	,	PUNCT	,	_	_	_	_	_
44	and	and	CCONJ	CC	_	_	_	_	_
45	AP	ap	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
46	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
47	1	1	NUM	CD	NumType=Card	_	_	_	_
48	transcriptional	transcriptional	ADJ	JJ	Degree=Pos	_	_	_	_
49	activity	activity	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
50	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1392
# text = Furthermore there was a clear-cut synergy between the PKC stimulator and the cAMP elevating agents.
1	Furthermore	furthermore	ADV	RB	_	_	_	_	_
2	there	there	PRON	EX	_	_	_	_	_
3	was	be	VERB	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
4	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
5	clear	clear	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
6	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
7	cut	cut	ADJ	JJ	Degree=Pos	_	_	_	_
8	synergy	synergy	NOUN	NN	Number=Sing	_	_	_	_
9	between	between	ADP	IN	_	_	_	_	_
10	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
11	PKC	Pkc	NOUN	NN	Number=Sing	_	_	_	_
12	stimulator	stimulator	NOUN	NN	Number=Sing	_	_	_	_
13	and	and	CCONJ	CC	_	_	_	_	_
14	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
15	cAMP	camp	NOUN	NN	Number=Sing	_	_	_	_
16	elevating	elevate	VERB	VBG	VerbForm=Ger	_	_	_	_
17	agents	agent	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
18	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1393
# text = The results demonstrate that the simultaneous activation of PKC and elevation of cAMP leads to an enhanced AP-1 transcriptional activity in a T-leukemia cell line, suggesting that the previously observed interaction between the parallel signal transduction pathways may have functional consequences at the level of gene transcription.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	results	result	NOUN	NNS	Number=Plur	_	_	_	_
3	demonstrate	demonstrate	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
4	that	that	SCONJ	IN	_	_	_	_	_
5	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
6	simultaneous	simultaneous	ADJ	JJ	Degree=Pos	_	_	_	_
7	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
8	of	of	ADP	IN	_	_	_	_	_
9	PKC	Pkc	NOUN	NN	Number=Sing	_	_	_	_
10	and	and	CCONJ	CC	_	_	_	_	_
11	elevation	elevation	NOUN	NN	Number=Sing	_	_	_	_
12	of	of	ADP	IN	_	_	_	_	_
13	cAMP	camp	NOUN	NN	Number=Sing	_	_	_	_
14	leads	lead	NOUN	NNS	Number=Plur	_	_	_	_
15	to	to	ADP	IN	_	_	_	_	_
16	an	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
17	enhanced	enhance	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
18	AP	ap	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
19	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
20	1	1	NUM	CD	NumType=Card	_	_	_	_
21	transcriptional	transcriptional	ADJ	JJ	Degree=Pos	_	_	_	_
22	activity	activity	NOUN	NN	Number=Sing	_	_	_	_
23	in	in	ADP	IN	_	_	_	_	_
24	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
25	T-	t-	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
26	leukemia	leukemia	NOUN	NN	Number=Sing	_	_	_	_
27	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
28	line	line	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
29	,	,	PUNCT	,	_	_	_	_	_
30	suggesting	suggest	VERB	VBG	VerbForm=Ger	_	_	_	_
31	that	that	SCONJ	IN	_	_	_	_	_
32	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
33	previously	previously	ADV	RB	_	_	_	_	_
34	observed	observe	ADJ	JJ	Degree=Pos	_	_	_	_
35	interaction	interaction	NOUN	NN	Number=Sing	_	_	_	_
36	between	between	ADP	IN	_	_	_	_	_
37	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
38	parallel	parallel	ADJ	JJ	Degree=Pos	_	_	_	_
39	signal	signal	NOUN	NN	Number=Sing	_	_	_	_
40	transduction	transduction	NOUN	NN	Number=Sing	_	_	_	_
41	pathways	pathway	NOUN	NNS	Number=Plur	_	_	_	_
42	may	may	AUX	MD	VerbForm=Fin	_	_	_	_
43	have	have	VERB	VB	VerbForm=Inf	_	_	_	_
44	functional	functional	ADJ	JJ	Degree=Pos	_	_	_	_
45	consequences	consequence	NOUN	NNS	Number=Plur	_	_	_	_
46	at	at	ADP	IN	_	_	_	_	_
47	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
48	level	level	NOUN	NN	Number=Sing	_	_	_	_
49	of	of	ADP	IN	_	_	_	_	_
50	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
51	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
52	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 1394
# text = Document 003002498 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	003002498	003002498	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 1395
# text = c-Myb and Ets proteins synergize to overcome transcriptional repression by ZEB.
1	c	c	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
2	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
3	Myb	Myb	NOUN	NN	Number=Sing	_	_	_	_
4	and	and	CCONJ	CC	_	_	_	_	_
5	Ets	ets	NOUN	NNS	Number=Plur	_	_	_	_
6	proteins	protein	NOUN	NNS	Number=Plur	_	_	_	_
7	synergize	synergize	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
8	to	to	PART	TO	_	_	_	_	_
9	overcome	overcome	VERB	VB	VerbForm=Inf	_	_	_	_
10	transcriptional	transcriptional	ADJ	JJ	Degree=Pos	_	_	_	_
11	repression	repression	NOUN	NN	Number=Sing	_	_	_	_
12	by	by	ADP	IN	_	_	_	_	_
13	ZEB	ZEB	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
14	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 1396
# text = The Zfh family of zinc finger/homeodomain proteins was first identified in Drosophila where it is required for differentiation of tissues such as the central nervous system and muscle.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	Zfh	Zfh	ADJ	JJ	Degree=Pos|NumType=Ord	_	_	_	_
3	family	family	NOUN	NN	Number=Sing	_	_	_	_
4	of	of	ADP	IN	_	_	_	_	_
5	zinc	zinc	NOUN	NN	Number=Sing	_	_	_	_
6	finger	finger	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
7	/	/	PUNCT	,	_	_	_	_	SpaceAfter=No
8	homeodomain	homeodomain	NOUN	NN	Number=Sing	_	_	_	_
9	proteins	protein	NOUN	NNS	Number=Plur	_	_	_	_
10	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
11	first	first	ADV	RB	_	_	_	_	_
12	identified	identify	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
13	in	in	ADP	IN	_	_	_	_	_
14	Drosophila	Drosophila	PROPN	NNP	Number=Sing	_	_	_	_
15	where	where	ADV	WRB	PronType=Rel	_	_	_	_
16	it	it	PRON	PRP	Case=Nom|Gender=Neut|Number=Sing|Person=3|PronType=Prs	_	_	_	_
17	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
18	required	require	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
19	for	for	ADP	IN	_	_	_	_	_
20	differentiation	differentiation	NOUN	NN	Number=Sing	_	_	_	_
21	of	of	ADP	IN	_	_	_	_	_
22	tissues	tissue	NOUN	NNS	Number=Plur	_	_	_	_
23	such	such	ADJ	JJ	Degree=Pos	_	_	_	_
24	as	as	ADP	IN	_	_	_	_	_
25	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
26	central	central	ADJ	JJ	Degree=Pos	_	_	_	_
27	nervous	nervous	ADJ	JJ	Degree=Pos	_	_	_	_
28	system	system	NOUN	NN	Number=Sing	_	_	_	_
29	and	and	CCONJ	CC	_	_	_	_	_
30	muscle	muscle	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
31	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1397
# text = ZEB, a vertebrate homolog of Zfh-1, binds a subset of E boxes and blocks myogenesis through transcriptional repression of muscle genes.
1	ZEB	ZEB	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
2	,	,	PUNCT	,	_	_	_	_	_
3	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
4	vertebrate	vertebrate	ADJ	JJ	Degree=Pos	_	_	_	_
5	homolog	homolog	NOUN	NN	Number=Sing	_	_	_	_
6	of	of	ADP	IN	_	_	_	_	_
7	Zfh	Zfh	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
8	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
9	1	1	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
10	,	,	PUNCT	,	_	_	_	_	_
11	binds	bind	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
12	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
13	subset	subset	NOUN	NN	Number=Sing	_	_	_	_
14	of	of	ADP	IN	_	_	_	_	_
15	E	e	NOUN	NN	Number=Sing	_	_	_	_
16	boxes	boxe	NOUN	NNS	Number=Plur	_	_	_	_
17	and	and	CCONJ	CC	_	_	_	_	_
18	blocks	block	NOUN	NNS	Number=Plur	_	_	_	_
19	myogenesis	myogenesis	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
20	through	through	ADP	IN	_	_	_	_	_
21	transcriptional	transcriptional	ADJ	JJ	Degree=Pos	_	_	_	_
22	repression	repression	NOUN	NN	Number=Sing	_	_	_	_
23	of	of	ADP	IN	_	_	_	_	_
24	muscle	muscle	NOUN	NN	Number=Sing	_	_	_	_
25	genes	gene	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
26	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1398
# text = We present evidence here that ZEB also has an important role in controlling hematopoietic gene transcription.
1	We	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
2	present	present	ADJ	JJ	Degree=Pos	_	_	_	_
3	evidence	evidence	NOUN	NN	Number=Sing	_	_	_	_
4	here	here	ADV	RB	PronType=Dem	_	_	_	_
5	that	that	SCONJ	IN	_	_	_	_	_
6	ZEB	ZEB	PROPN	NNP	Number=Sing	_	_	_	_
7	also	also	ADV	RB	_	_	_	_	_
8	has	have	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
9	an	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
10	important	important	ADJ	JJ	Degree=Pos	_	_	_	_
11	role	role	NOUN	NN	Number=Sing	_	_	_	_
12	in	in	SCONJ	IN	_	_	_	_	_
13	controlling	controlle	VERB	VBG	VerbForm=Ger	_	_	_	_
14	hematopoietic	hematopoietic	ADJ	JJ	Degree=Pos	_	_	_	_
15	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
16	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
17	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1399
# text = Two families of transcription factors that are required for normal hematopoiesis are c-Myb and Ets.
1	Two	two	NUM	CD	NumType=Card	_	_	_	_
2	families	family	NOUN	NNS	Number=Plur	_	_	_	_
3	of	of	ADP	IN	_	_	_	_	_
4	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
5	factors	factor	NOUN	NNS	Number=Plur	_	_	_	_
6	that	that	PRON	WDT	PronType=Rel	_	_	_	_
7	are	be	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
8	required	require	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
9	for	for	ADP	IN	_	_	_	_	_
10	normal	normal	ADJ	JJ	Degree=Pos	_	_	_	_
11	hematopoiesis	hematopoiesis	NOUN	NN	Number=Sing	_	_	_	_
12	are	be	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
13	c-	c-	SYM	NFP	_	_	_	_	SpaceAfter=No
14	Myb	Myb	PROPN	NNP	Number=Sing	_	_	_	_
15	and	and	CCONJ	CC	_	_	_	_	_
16	Ets	Ets	PROPN	NNPS	Number=Plur	_	_	_	SpaceAfter=No
17	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1400
# text = These factors act synergistically to activate transcription, and this synergy is required for transcription of at least several important hematopoietic genes.
1	These	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
2	factors	factor	NOUN	NNS	Number=Plur	_	_	_	_
3	act	act	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
4	synergistically	synergistically	ADV	RB	_	_	_	_	_
5	to	to	PART	TO	_	_	_	_	_
6	activate	activate	VERB	VB	VerbForm=Inf	_	_	_	_
7	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
8	,	,	PUNCT	,	_	_	_	_	_
9	and	and	CCONJ	CC	_	_	_	_	_
10	this	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
11	synergy	synergy	NOUN	NN	Number=Sing	_	_	_	_
12	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
13	required	require	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
14	for	for	ADP	IN	_	_	_	_	_
15	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
16	of	of	ADP	IN	_	_	_	_	_
17	at	at	ADV	RB	_	_	_	_	_
18	least	least	ADV	RBS	Degree=Sup	_	_	_	_
19	several	several	ADJ	JJ	Degree=Pos	_	_	_	_
20	important	important	ADJ	JJ	Degree=Pos	_	_	_	_
21	hematopoietic	hematopoietic	ADJ	JJ	Degree=Pos	_	_	_	_
22	genes	gene	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
23	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1401
# text = ZEB blocks the activity of c-Myb and Ets individually, but together the factors synergize to resist this repression.
1	ZEB	ZEB	PROPN	NNP	Number=Sing	_	_	_	_
2	blocks	block	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
3	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
4	activity	activity	NOUN	NN	Number=Sing	_	_	_	_
5	of	of	ADP	IN	_	_	_	_	_
6	c	c	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
7	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
8	Myb	Myb	PROPN	NNP	Number=Sing	_	_	_	_
9	and	and	CCONJ	CC	_	_	_	_	_
10	Ets	ets	PROPN	NNPS	Number=Plur	_	_	_	_
11	individually	individually	ADV	RB	_	_	_	_	SpaceAfter=No
12	,	,	PUNCT	,	_	_	_	_	_
13	but	but	CCONJ	CC	_	_	_	_	_
14	together	together	ADV	RB	_	_	_	_	_
15	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
16	factors	factor	NOUN	NNS	Number=Plur	_	_	_	_
17	synergize	synergize	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
18	to	to	PART	TO	_	_	_	_	_
19	resist	resist	VERB	VB	VerbForm=Inf	_	_	_	_
20	this	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
21	repression	repression	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
22	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1402
# text = Such repression imposes a requirement for both c-Myb and Ets for transcriptional activity, providing one explanation for why synergy between these factors is important.
1	Such	such	ADJ	JJ	Degree=Pos	_	_	_	_
2	repression	repression	NOUN	NN	Number=Sing	_	_	_	_
3	imposes	impose	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
4	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
5	requirement	requirement	NOUN	NN	Number=Sing	_	_	_	_
6	for	for	ADP	IN	_	_	_	_	_
7	both	both	CCONJ	CC	_	_	_	_	_
8	c-	c-	SYM	NFP	_	_	_	_	SpaceAfter=No
9	Myb	Myb	NOUN	NN	Number=Sing	_	_	_	_
10	and	and	CCONJ	CC	_	_	_	_	_
11	Ets	et	NOUN	NNS	Number=Plur	_	_	_	_
12	for	for	ADP	IN	_	_	_	_	_
13	transcriptional	transcriptional	ADJ	JJ	Degree=Pos	_	_	_	_
14	activity	activity	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
15	,	,	PUNCT	,	_	_	_	_	_
16	providing	provide	VERB	VBG	VerbForm=Ger	_	_	_	_
17	one	one	NUM	CD	NumType=Card	_	_	_	_
18	explanation	explanation	NOUN	NN	Number=Sing	_	_	_	_
19	for	for	SCONJ	IN	_	_	_	_	_
20	why	why	ADV	WRB	PronType=Int	_	_	_	_
21	synergy	synergy	NOUN	NN	Number=Sing	_	_	_	_
22	between	between	ADP	IN	_	_	_	_	_
23	these	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
24	factors	factor	NOUN	NNS	Number=Plur	_	_	_	_
25	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
26	important	important	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
27	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1403
# text = The balance between repression by ZEB and transcriptional activation by c-Myb/Ets provides a flexible regulatory mechanism for controlling gene expression in hematopoietic cells.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	balance	balance	NOUN	NN	Number=Sing	_	_	_	_
3	between	between	ADP	IN	_	_	_	_	_
4	repression	repression	NOUN	NN	Number=Sing	_	_	_	_
5	by	by	ADP	IN	_	_	_	_	_
6	ZEB	ZEB	PROPN	NNP	Number=Sing	_	_	_	_
7	and	and	CCONJ	CC	_	_	_	_	_
8	transcriptional	transcriptional	ADJ	JJ	Degree=Pos	_	_	_	_
9	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
10	by	by	ADP	IN	_	_	_	_	_
11	c-	c-	SYM	NFP	_	_	_	_	SpaceAfter=No
12	Myb/	Myb/	SYM	NFP	_	_	_	_	SpaceAfter=No
13	Ets	ets	PROPN	NNPS	Number=Plur	_	_	_	_
14	provides	provide	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
15	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
16	flexible	flexible	ADJ	JJ	Degree=Pos	_	_	_	_
17	regulatory	regulatory	ADJ	JJ	Degree=Pos	_	_	_	_
18	mechanism	mechanism	NOUN	NN	Number=Sing	_	_	_	_
19	for	for	SCONJ	IN	_	_	_	_	_
20	controlling	controlle	VERB	VBG	VerbForm=Ger	_	_	_	_
21	gene	gene	ADJ	JJ	Degree=Pos	_	_	_	_
22	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
23	in	in	ADP	IN	_	_	_	_	_
24	hematopoietic	hematopoietic	ADJ	JJ	Degree=Pos	_	_	_	_
25	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
26	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1404
# text = We demonstrate that one target of this positive/negative regulation in vivo is the alpha4 integrin, which play a key role in normal hematopoiesis and function of mature leukocytes.
1	We	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
2	demonstrate	demonstrate	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
3	that	that	SCONJ	IN	_	_	_	_	_
4	one	one	NUM	CD	NumType=Card	_	_	_	_
5	target	target	NOUN	NN	Number=Sing	_	_	_	_
6	of	of	ADP	IN	_	_	_	_	_
7	this	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
8	positive	positive	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
9	/	/	PUNCT	,	_	_	_	_	SpaceAfter=No
10	negative	negative	ADJ	JJ	Degree=Pos	_	_	_	_
11	regulation	regulation	NOUN	NN	Number=Sing	_	_	_	_
12	in	in	ADP	IN	_	_	_	_	_
13	vivo	vivo	NOUN	NN	Number=Sing	_	_	_	_
14	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
15	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
16	alpha4	alpha4	NOUN	NN	Number=Sing	_	_	_	_
17	integrin	integrin	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
18	,	,	PUNCT	,	_	_	_	_	_
19	which	which	PRON	WDT	PronType=Rel	_	_	_	_
20	play	play	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
21	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
22	key	key	ADJ	JJ	Degree=Pos	_	_	_	_
23	role	role	NOUN	NN	Number=Sing	_	_	_	_
24	in	in	ADP	IN	_	_	_	_	_
25	normal	normal	ADJ	JJ	Degree=Pos	_	_	_	_
26	hematopoiesis	hematopoiesis	NOUN	NN	Number=Sing	_	_	_	_
27	and	and	CCONJ	CC	_	_	_	_	_
28	function	function	NOUN	NN	Number=Sing	_	_	_	_
29	of	of	ADP	IN	_	_	_	_	_
30	mature	mature	ADJ	JJ	Degree=Pos	_	_	_	_
31	leukocytes	leukocyte	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
32	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 1405
# text = Document 003002502 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	003002502	003002502	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 1406
# text = Differential effects of lipopolysaccharide and tumor necrosis factor on monocytic IkappaB kinase signalsome activation and IkappaB proteolysis.
1	Differential	differential	ADJ	JJ	Degree=Pos	_	_	_	_
2	effects	effect	NOUN	NNS	Number=Plur	_	_	_	_
3	of	of	ADP	IN	_	_	_	_	_
4	lipopolysaccharide	lipopolysaccharide	NOUN	NN	Number=Sing	_	_	_	_
5	and	and	CCONJ	CC	_	_	_	_	_
6	tumor	tumor	NOUN	NN	Number=Sing	_	_	_	_
7	necrosis	necrosis	NOUN	NN	Number=Sing	_	_	_	_
8	factor	factor	NOUN	NN	Number=Sing	_	_	_	_
9	on	on	ADP	IN	_	_	_	_	_
10	monocytic	monocytic	ADJ	JJ	Degree=Pos	_	_	_	_
11	IkappaB	IkappaB	NOUN	NN	Number=Sing	_	_	_	_
12	kinase	kinase	NOUN	NN	Number=Sing	_	_	_	_
13	signalsome	signalsome	NOUN	NN	Number=Sing	_	_	_	_
14	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
15	and	and	CCONJ	CC	_	_	_	_	_
16	IkappaB	Ikappab	NOUN	NN	Number=Sing	_	_	_	_
17	proteolysis	proteolysis	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
18	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 1407
# text = The inflammatory mediators lipopolysaccharide (LPS) and tumor necrosis factor (TNF) are potent activators of NF-kappaB.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	inflammatory	inflammatory	ADJ	JJ	Degree=Pos	_	_	_	_
3	mediators	mediator	NOUN	NNS	Number=Plur	_	_	_	_
4	lipopolysaccharide	lipopolysaccharide	NOUN	NN	Number=Sing	_	_	_	_
5	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
6	LPS	LPS	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
7	)	)	PUNCT	-RRB-	_	_	_	_	_
8	and	and	CCONJ	CC	_	_	_	_	_
9	tumor	tumor	NOUN	NN	Number=Sing	_	_	_	_
10	necrosis	necrosis	NOUN	NN	Number=Sing	_	_	_	_
11	factor	factor	NOUN	NN	Number=Sing	_	_	_	_
12	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
13	TNF	TNF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
14	)	)	PUNCT	-RRB-	_	_	_	_	_
15	are	be	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
16	potent	potent	ADJ	JJ	Degree=Pos	_	_	_	_
17	activators	activator	NOUN	NNS	Number=Plur	_	_	_	_
18	of	of	ADP	IN	_	_	_	_	_
19	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
20	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
21	kappaB	kappaB	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
22	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1408
# text = This study compared the effect of these stimuli on endogenous IkappaB kinase (IKK) signalsome activation and IkappaB phosphorylation/proteolysis in human monocytic cells and investigated the role of the signalsome proteins IKK-alpha, IKK-beta, NF-kappaB-inducing kinase (NIK), IKK-gamma (NF-kappaB essential modulator), and IKK complex-associated protein.
1	This	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
2	study	study	NOUN	NN	Number=Sing	_	_	_	_
3	compared	compare	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
4	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
5	effect	effect	NOUN	NN	Number=Sing	_	_	_	_
6	of	of	ADP	IN	_	_	_	_	_
7	these	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
8	stimuli	stimuli	NOUN	NN	Number=Sing	_	_	_	_
9	on	on	ADP	IN	_	_	_	_	_
10	endogenous	endogenous	ADJ	JJ	Degree=Pos	_	_	_	_
11	IkappaB	Ikappab	NOUN	NN	Number=Sing	_	_	_	_
12	kinase	kinase	NOUN	NN	Number=Sing	_	_	_	_
13	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
14	IKK	IKK	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
15	)	)	PUNCT	-RRB-	_	_	_	_	_
16	signalsome	signalsome	ADJ	JJ	Degree=Pos	_	_	_	_
17	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
18	and	and	CCONJ	CC	_	_	_	_	_
19	IkappaB	Ikappab	NOUN	NN	Number=Sing	_	_	_	_
20	phosphorylation	phosphorylation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
21	/	/	PUNCT	,	_	_	_	_	SpaceAfter=No
22	proteolysis	proteolysis	NOUN	NN	Number=Sing	_	_	_	_
23	in	in	ADP	IN	_	_	_	_	_
24	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
25	monocytic	monocytic	ADJ	JJ	Degree=Pos	_	_	_	_
26	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
27	and	and	CCONJ	CC	_	_	_	_	_
28	investigated	investigate	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
29	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
30	role	role	NOUN	NN	Number=Sing	_	_	_	_
31	of	of	ADP	IN	_	_	_	_	_
32	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
33	signalsome	signalsome	ADJ	JJ	Degree=Pos	_	_	_	_
34	proteins	protein	NOUN	NNS	Number=Plur	_	_	_	_
35	IKK	IKK	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
36	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
37	alpha	alpha	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
38	,	,	PUNCT	,	_	_	_	_	_
39	IKK	IKK	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
40	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
41	beta	beta	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
42	,	,	PUNCT	,	_	_	_	_	_
43	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
44	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
45	kappaB	kappaB	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
46	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
47	inducing	induce	VERB	VBG	VerbForm=Ger	_	_	_	_
48	kinase	kinase	NOUN	NN	Number=Sing	_	_	_	_
49	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
50	NIK	NIK	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
51	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
52	,	,	PUNCT	,	_	_	_	_	_
53	IKK	IKK	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
54	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
55	gamma	gamma	PROPN	NNP	Number=Sing	_	_	_	_
56	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
57	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
58	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
59	kappaB	kappaB	PROPN	NNP	Number=Sing	_	_	_	_
60	essential	essential	ADJ	JJ	Degree=Pos	_	_	_	_
61	modulator	modulator	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
62	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
63	,	,	PUNCT	,	_	_	_	_	_
64	and	and	CCONJ	CC	_	_	_	_	_
65	IKK	IKK	PROPN	NNP	Number=Sing	_	_	_	_
66	complex	complex	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
67	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
68	associated	associate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
69	protein	protein	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
70	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1409
# text = Kinase assays showed that TNF elicited a rapid but short-lived induction of IKK activity with a 3-fold greater effect on IKK-alpha than on IKK-beta, peaking at 5 min.
1	Kinase	Kinase	ADJ	JJ	Degree=Pos	_	_	_	_
2	assays	assays	NOUN	NNS	Number=Plur	_	_	_	_
3	showed	show	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
4	that	that	SCONJ	IN	_	_	_	_	_
5	TNF	TNF	PROPN	NNP	Number=Sing	_	_	_	_
6	elicited	elicit	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
7	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
8	rapid	rapid	ADJ	JJ	Degree=Pos	_	_	_	_
9	but	but	CCONJ	CC	_	_	_	_	_
10	short	short	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
11	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
12	lived	lived	ADJ	JJ	Degree=Pos	_	_	_	_
13	induction	induction	NOUN	NN	Number=Sing	_	_	_	_
14	of	of	ADP	IN	_	_	_	_	_
15	IKK	IKK	NUM	CD	NumType=Card	_	_	_	_
16	activity	activity	NOUN	NN	Number=Sing	_	_	_	_
17	with	with	ADP	IN	_	_	_	_	_
18	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
19	3	3	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
20	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
21	fold	fold	VERB	VB	VerbForm=Inf	_	_	_	_
22	greater	greater	ADJ	JJR	Degree=Cmp	_	_	_	_
23	effect	effect	NOUN	NN	Number=Sing	_	_	_	_
24	on	on	ADP	IN	_	_	_	_	_
25	IKK	IKK	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
26	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
27	alpha	alpha	ADV	RB	_	_	_	_	_
28	than	than	ADP	IN	_	_	_	_	_
29	on	on	ADP	IN	_	_	_	_	_
30	IKK	IKK	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
31	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
32	beta	beta	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
33	,	,	PUNCT	,	_	_	_	_	_
34	peaking	peak	VERB	VBG	VerbForm=Ger	_	_	_	_
35	at	at	ADP	IN	_	_	_	_	_
36	5	5	NUM	CD	NumType=Card	_	_	_	_
37	min	min	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
38	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1410
# text = In contrast, LPS predominantly stimulated IKK-beta activity, which slowly increased, peaking at 30 min.
1	In	in	ADP	IN	_	_	_	_	_
2	contrast	contrast	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
3	,	,	PUNCT	,	_	_	_	_	_
4	LPS	LPS	INTJ	UH	_	_	_	_	_
5	predominantly	predominantly	ADV	RB	_	_	_	_	_
6	stimulated	stimulate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
7	IKK	IKK	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
8	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
9	beta	beta	NOUN	NN	Number=Sing	_	_	_	_
10	activity	activity	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
11	,	,	PUNCT	,	_	_	_	_	_
12	which	which	PRON	WDT	PronType=Rel	_	_	_	_
13	slowly	slowly	ADV	RB	_	_	_	_	_
14	increased	increase	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	SpaceAfter=No
15	,	,	PUNCT	,	_	_	_	_	_
16	peaking	peak	VERB	VBG	VerbForm=Ger	_	_	_	_
17	at	at	ADP	IN	_	_	_	_	_
18	30	30	NUM	CD	NumType=Card	_	_	_	_
19	min	min	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
20	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1411
# text = A second peak was observed at a later time point following LPS stimulation, which consisted of both IKK-alpha and -beta activity.
1	A	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
2	second	second	ADJ	JJ	Degree=Pos|NumType=Ord	_	_	_	_
3	peak	peak	NOUN	NN	Number=Sing	_	_	_	_
4	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
5	observed	observe	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
6	at	at	ADP	IN	_	_	_	_	_
7	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
8	later	later	ADJ	JJR	Degree=Cmp	_	_	_	_
9	time	time	NOUN	NN	Number=Sing	_	_	_	_
10	point	point	NOUN	NN	Number=Sing	_	_	_	_
11	following	follow	VERB	VBG	VerbForm=Ger	_	_	_	_
12	LPS	Lps	ADJ	JJ	Degree=Pos	_	_	_	_
13	stimulation	stimulation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
14	,	,	PUNCT	,	_	_	_	_	_
15	which	which	PRON	WDT	PronType=Rel	_	_	_	_
16	consisted	consist	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
17	of	of	ADP	IN	_	_	_	_	_
18	both	both	DET	DT	_	_	_	_	_
19	IKK	IKK	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
20	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
21	alpha	alpha	NOUN	NN	Number=Sing	_	_	_	_
22	and	and	CCONJ	CC	_	_	_	_	_
23	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
24	beta	beta	ADJ	JJ	Degree=Pos	_	_	_	_
25	activity	activity	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
26	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1412
# text = The endogenous levels of the signalsome components were unaffected by stimulation.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	endogenous	endogenous	ADJ	JJ	Degree=Pos	_	_	_	_
3	levels	level	NOUN	NNS	Number=Plur	_	_	_	_
4	of	of	ADP	IN	_	_	_	_	_
5	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
6	signalsome	signalsome	ADJ	JJ	Degree=Pos	_	_	_	_
7	components	component	NOUN	NNS	Number=Plur	_	_	_	_
8	were	be	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
9	unaffected	unaffect	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
10	by	by	ADP	IN	_	_	_	_	_
11	stimulation	stimulation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
12	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1413
# text = Furthermore, our studies showed association of the IKK-alpha/beta heterodimer with NIK, IkappaB-alpha and -epsilon in unstimulated cells.
1	Furthermore	furthermore	ADV	RB	_	_	_	_	SpaceAfter=No
2	,	,	PUNCT	,	_	_	_	_	_
3	our	we	PRON	PRP$	Number=Plur|Person=1|Poss=Yes|PronType=Prs	_	_	_	_
4	studies	study	NOUN	NNS	Number=Plur	_	_	_	_
5	showed	show	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
6	association	association	NOUN	NN	Number=Sing	_	_	_	_
7	of	of	ADP	IN	_	_	_	_	_
8	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
9	IKK	IKK	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
10	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
11	alpha	alpha	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
12	/	/	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
13	beta	beta	NOUN	NN	Number=Sing	_	_	_	_
14	heterodimer	heterodimer	NOUN	NN	Number=Sing	_	_	_	_
15	with	with	ADP	IN	_	_	_	_	_
16	NIK	NIK	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
17	,	,	PUNCT	,	_	_	_	_	_
18	IkappaB	IkappaB	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
19	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
20	alpha	alpha	PROPN	NNP	Number=Sing	_	_	_	_
21	and	and	CCONJ	CC	_	_	_	_	_
22	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
23	epsilon	epsilon	NOUN	NN	Number=Sing	_	_	_	_
24	in	in	ADP	IN	_	_	_	_	_
25	unstimulated	unstimulated	ADJ	JJ	Degree=Pos	_	_	_	_
26	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
27	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1414
# text = Exposure to LPS or TNF led to differential patterns of IkappaB-alpha and IkappaB-epsilon disappearance from and reassembly with the signalsome, whereas IKK-alpha, IKK-beta, and NIK remained complex-associated.
1	Exposure	exposure	NOUN	NN	Number=Sing	_	_	_	_
2	to	to	ADP	IN	_	_	_	_	_
3	LPS	LPS	PROPN	NNP	Number=Sing	_	_	_	_
4	or	or	CCONJ	CC	_	_	_	_	_
5	TNF	TNF	PROPN	NNP	Number=Sing	_	_	_	_
6	led	lead	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
7	to	to	ADP	IN	_	_	_	_	_
8	differential	differential	ADJ	JJ	Degree=Pos	_	_	_	_
9	patterns	pattern	NOUN	NNS	Number=Plur	_	_	_	_
10	of	of	ADP	IN	_	_	_	_	_
11	IkappaB	IkappaB	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
12	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
13	alpha	alpha	NOUN	NN	Number=Sing	_	_	_	_
14	and	and	CCONJ	CC	_	_	_	_	_
15	IkappaB	Ikappab	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
16	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
17	epsilon	epsilon	NOUN	NN	Number=Sing	_	_	_	_
18	disappearance	disappearance	NOUN	NN	Number=Sing	_	_	_	_
19	from	from	ADP	IN	_	_	_	_	_
20	and	and	CCONJ	CC	_	_	_	_	_
21	reassembly	reassembly	ADV	RB	_	_	_	_	_
22	with	with	ADP	IN	_	_	_	_	_
23	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
24	signalsome	signalsome	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
25	,	,	PUNCT	,	_	_	_	_	_
26	whereas	whereas	SCONJ	IN	_	_	_	_	_
27	IKK	Ikk	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
28	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
29	alpha	alpha	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
30	,	,	PUNCT	,	_	_	_	_	_
31	IKK	IKK	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
32	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
33	beta	beta	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
34	,	,	PUNCT	,	_	_	_	_	_
35	and	and	CCONJ	CC	_	_	_	_	_
36	NIK	NIK	PROPN	NNP	Number=Sing	_	_	_	_
37	remained	remain	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
38	complex	complex	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
39	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
40	associated	associate	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
41	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1415
# text = NIK cannot phosphorylate IkappaB-alpha directly, but it appears to be a functionally important subunit, because mutated NIK inhibited stimulus-induced kappaB-dependent transcription more effectively than mutated IKK-alpha or -beta.
1	NIK	NIK	ADV	RB	_	_	_	_	_
2	can	can	AUX	MD	VerbForm=Fin	_	_	_	SpaceAfter=No
3	not	not	PART	RB	_	_	_	_	_
4	phosphorylate	phosphorylate	VERB	VB	VerbForm=Inf	_	_	_	_
5	IkappaB	Ikappab	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
6	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
7	alpha	alpha	NOUN	NN	Number=Sing	_	_	_	_
8	directly	directly	ADV	RB	_	_	_	_	SpaceAfter=No
9	,	,	PUNCT	,	_	_	_	_	_
10	but	but	CCONJ	CC	_	_	_	_	_
11	it	it	PRON	PRP	Case=Nom|Gender=Neut|Number=Sing|Person=3|PronType=Prs	_	_	_	_
12	appears	appear	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
13	to	to	PART	TO	_	_	_	_	_
14	be	be	AUX	VB	VerbForm=Inf	_	_	_	_
15	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
16	functionally	functionally	ADV	RB	_	_	_	_	_
17	important	important	ADJ	JJ	Degree=Pos	_	_	_	_
18	subunit	subunit	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
19	,	,	PUNCT	,	_	_	_	_	_
20	because	because	SCONJ	IN	_	_	_	_	_
21	mutated	mutate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
22	NIK	NIK	PROPN	NNP	Number=Sing	_	_	_	_
23	inhibited	inhibit	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
24	stimulus	stimulus	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
25	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
26	induced	induce	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
27	kappaB	kappab	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
28	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
29	dependent	dependent	ADJ	JJ	Degree=Pos	_	_	_	_
30	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
31	more	more	ADV	RBR	_	_	_	_	_
32	effectively	effectively	ADV	RB	_	_	_	_	_
33	than	than	ADP	IN	_	_	_	_	_
34	mutated	mutate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
35	IKK	IKK	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
36	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
37	alpha	alpha	NOUN	NN	Number=Sing	_	_	_	_
38	or	or	CCONJ	CC	_	_	_	_	_
39	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
40	beta	beta	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
41	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1416
# text = Overexpression of IKK complex-associated protein inhibited stimulus-mediated transcription, whereas NF-kappaB essential modulator enhanced it.
1	Overexpression	Overexpression	NOUN	NN	Number=Sing	_	_	_	_
2	of	of	ADP	IN	_	_	_	_	_
3	IKK	IKK	PROPN	NNP	Number=Sing	_	_	_	_
4	complex	complex	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
5	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
6	associated	associate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
7	protein	protein	NOUN	NN	Number=Sing	_	_	_	_
8	inhibited	inhibit	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
9	stimulus	stimulus	ADV	RB	_	_	_	_	SpaceAfter=No
10	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
11	mediated	mediate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
12	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
13	,	,	PUNCT	,	_	_	_	_	_
14	whereas	whereas	SCONJ	IN	_	_	_	_	_
15	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
16	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
17	kappaB	kappaB	PROPN	NNP	Number=Sing	_	_	_	_
18	essential	essential	ADJ	JJ	Degree=Pos	_	_	_	_
19	modulator	modulator	NOUN	NN	Number=Sing	_	_	_	_
20	enhanced	enhance	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
21	it	it	PRON	PRP	Case=Acc|Gender=Neut|Number=Sing|Person=3|PronType=Prs	_	_	_	SpaceAfter=No
22	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1417
# text = The understanding of LPS- and TNF-induced signaling may allow the development of specific strategies to treat sepsis-associated disease.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	understanding	understanding	NOUN	NN	Number=Sing	_	_	_	_
3	of	of	ADP	IN	_	_	_	_	_
4	LPS	LPS	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
5	-	-	PUNCT	,	_	_	_	_	_
6	and	and	CCONJ	CC	_	_	_	_	_
7	TNF	Tnf	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
8	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
9	induced	induce	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
10	signaling	signaling	NOUN	NN	Number=Sing	_	_	_	_
11	may	may	AUX	MD	VerbForm=Fin	_	_	_	_
12	allow	allow	VERB	VB	VerbForm=Inf	_	_	_	_
13	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
14	development	development	NOUN	NN	Number=Sing	_	_	_	_
15	of	of	ADP	IN	_	_	_	_	_
16	specific	specific	ADJ	JJ	Degree=Pos	_	_	_	_
17	strategies	strategy	NOUN	NNS	Number=Plur	_	_	_	_
18	to	to	PART	TO	_	_	_	_	_
19	treat	treat	VERB	VB	VerbForm=Inf	_	_	_	_
20	sepsis-	sepsis-	PUNCT	:	_	_	_	_	SpaceAfter=No
21	associated	associate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
22	disease	disease	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
23	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 1418
# text = Document 003002513 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	003002513	003002513	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 1419
# text = Extinction of immunoglobulin gene expression in B cells upon fusion with HeLa cells is preceded by rapid nuclear depletion of essential transcription factors and is accompanied by widespread inactivation of genes expressed in a B cell-specific manner.
1	Extinction	extinction	NOUN	NN	Number=Sing	_	_	_	_
2	of	of	ADP	IN	_	_	_	_	_
3	immunoglobulin	immunoglobulin	ADJ	JJ	Degree=Pos	_	_	_	_
4	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
5	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
6	in	in	ADP	IN	_	_	_	_	_
7	B	b	ADJ	JJ	Degree=Pos	_	_	_	_
8	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
9	upon	upon	ADP	IN	_	_	_	_	_
10	fusion	fusion	NOUN	NN	Number=Sing	_	_	_	_
11	with	with	ADP	IN	_	_	_	_	_
12	HeLa	HeLa	PROPN	NNP	Number=Sing	_	_	_	_
13	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
14	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
15	preceded	preced	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
16	by	by	ADP	IN	_	_	_	_	_
17	rapid	rapid	ADJ	JJ	Degree=Pos	_	_	_	_
18	nuclear	nuclear	ADJ	JJ	Degree=Pos	_	_	_	_
19	depletion	depletion	NOUN	NN	Number=Sing	_	_	_	_
20	of	of	ADP	IN	_	_	_	_	_
21	essential	essential	ADJ	JJ	Degree=Pos	_	_	_	_
22	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
23	factors	factor	NOUN	NNS	Number=Plur	_	_	_	_
24	and	and	CCONJ	CC	_	_	_	_	_
25	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
26	accompanied	accompany	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
27	by	by	ADP	IN	_	_	_	_	_
28	widespread	widespread	ADJ	JJ	Degree=Pos	_	_	_	_
29	inactivation	inactivation	NOUN	NN	Number=Sing	_	_	_	_
30	of	of	ADP	IN	_	_	_	_	_
31	genes	gene	NOUN	NNS	Number=Plur	_	_	_	_
32	expressed	express	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
33	in	in	ADP	IN	_	_	_	_	_
34	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
35	B	b	PROPN	NNP	Number=Sing	_	_	_	_
36	cell	cell	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
37	-specific	-specific	ADJ	JJ	Degree=Pos	_	_	_	_
38	manner	manner	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
39	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 1420
# text = When immunoglobulin
1	When	when	ADV	WRB	PronType=Int	_	_	_	_
2	immunoglobulin	immunoglobulin	ADJ	JJ	Degree=Pos	_	_	_	_

# sent_id = 1421
# text = (Ig) expressing B cells are fused with non-B cells, Ig expression is rapidly suppressed at the level of transcription, a phenomenon termed extinction.
1	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
2	Ig	ig	X	ADD	_	_	_	_	SpaceAfter=No
3	)	)	PUNCT	-RRB-	_	_	_	_	_
4	expressing	express	VERB	VBG	VerbForm=Ger	_	_	_	_
5	B	b	ADJ	JJ	Degree=Pos	_	_	_	_
6	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
7	are	be	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
8	fused	fuse	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
9	with	with	ADP	IN	_	_	_	_	_
10	non	non	X	AFX	_	_	_	_	SpaceAfter=No
11	-B	-b	ADJ	JJ	Degree=Pos	_	_	_	_
12	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
13	,	,	PUNCT	,	_	_	_	_	_
14	Ig	ig	PROPN	NNP	Number=Sing	_	_	_	_
15	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
16	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
17	rapidly	rapidly	ADV	RB	_	_	_	_	_
18	suppressed	suppress	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
19	at	at	ADP	IN	_	_	_	_	_
20	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
21	level	level	NOUN	NN	Number=Sing	_	_	_	_
22	of	of	ADP	IN	_	_	_	_	_
23	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
24	,	,	PUNCT	,	_	_	_	_	_
25	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
26	phenomenon	phenomenon	NOUN	NN	Number=Sing	_	_	_	_
27	termed	term	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
28	extinction	extinction	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
29	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1422
# text = Here we demonstrate that fusion of HeLa cells with either diploid or tetraploid B cells (Daudi) results in widespread extinction of several other B cell-encoded genes that are expressed in a B cell-specific manner.
1	Here	here	ADV	RB	PronType=Dem	_	_	_	_
2	we	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
3	demonstrate	demonstrate	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
4	that	that	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
5	fusion	fusion	NOUN	NN	Number=Sing	_	_	_	_
6	of	of	ADP	IN	_	_	_	_	_
7	HeLa	Hela	PROPN	NNP	Number=Sing	_	_	_	_
8	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
9	with	with	ADP	IN	_	_	_	_	_
10	either	either	CCONJ	CC	_	_	_	_	_
11	diploid	diploid	ADJ	JJ	Degree=Pos	_	_	_	_
12	or	or	CCONJ	CC	_	_	_	_	_
13	tetraploid	tetraploid	ADJ	JJ	Degree=Pos	_	_	_	_
14	B	b	ADJ	JJ	Degree=Pos	_	_	_	_
15	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
16	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
17	Daudi	Daudi	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
18	)	)	PUNCT	-RRB-	_	_	_	_	_
19	results	result	NOUN	NNS	Number=Plur	_	_	_	_
20	in	in	ADP	IN	_	_	_	_	_
21	widespread	widespread	ADJ	JJ	Degree=Pos	_	_	_	_
22	extinction	extinction	NOUN	NN	Number=Sing	_	_	_	_
23	of	of	ADP	IN	_	_	_	_	_
24	several	several	ADJ	JJ	Degree=Pos	_	_	_	_
25	other	other	ADJ	JJ	Degree=Pos	_	_	_	_
26	B	b	NOUN	NN	Number=Sing	_	_	_	_
27	cell	cell	ADV	RB	Degree=Pos	_	_	_	SpaceAfter=No
28	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
29	encoded	encod	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
30	genes	gene	NOUN	NNS	Number=Plur	_	_	_	_
31	that	that	PRON	WDT	PronType=Rel	_	_	_	_
32	are	be	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
33	expressed	express	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
34	in	in	ADP	IN	_	_	_	_	_
35	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
36	B	b	PROPN	NNP	Number=Sing	_	_	_	_
37	cell	cell	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
38	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
39	specific	specific	ADJ	JJ	Degree=Pos	_	_	_	_
40	manner	manner	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
41	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1423
# text = In contrast, expression of B cell-expressed genes that are not dependent on cell-specific controls is unaffected.
1	In	in	ADP	IN	_	_	_	_	_
2	contrast	contrast	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
3	,	,	PUNCT	,	_	_	_	_	_
4	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
5	of	of	ADP	IN	_	_	_	_	_
6	B	b	ADJ	JJ	Degree=Pos	_	_	_	_
7	cell	cell	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
8	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
9	expressed	express	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
10	genes	gene	NOUN	NNS	Number=Plur	_	_	_	_
11	that	that	PRON	WDT	PronType=Rel	_	_	_	_
12	are	be	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
13	not	not	PART	RB	_	_	_	_	_
14	dependent	dependent	ADJ	JJ	Degree=Pos	_	_	_	_
15	on	on	ADP	IN	_	_	_	_	_
16	cell	cell	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
17	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
18	specific	specific	ADJ	JJ	Degree=Pos	_	_	_	_
19	controls	controls	NOUN	NN	Number=Sing	_	_	_	_
20	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
21	unaffected	unaffected	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
22	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1424
# text = We show that the molecular mechanism(s) underlying Ig gene extinction can be explained, at least in part, by a lack of transcription factors that are essential for Ig gene transcription.
1	We	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
2	show	show	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
3	that	that	SCONJ	IN	_	_	_	_	_
4	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
5	molecular	molecular	ADJ	JJ	Degree=Pos	_	_	_	_
6	mechanism	mechanism	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
7	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
8	s	s	X	AFX	_	_	_	_	SpaceAfter=No
9	)	)	PUNCT	-RRB-	_	_	_	_	_
10	underlying	underly	ADJ	JJ	Degree=Pos	_	_	_	_
11	Ig	ig	NOUN	NN	Number=Sing	_	_	_	_
12	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
13	extinction	extinction	NOUN	NN	Number=Sing	_	_	_	_
14	can	can	AUX	MD	VerbForm=Fin	_	_	_	_
15	be	be	AUX	VB	VerbForm=Inf	_	_	_	_
16	explained	explain	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	SpaceAfter=No
17	,	,	PUNCT	,	_	_	_	_	_
18	at	at	ADV	RB	_	_	_	_	_
19	least	least	ADV	RBS	Degree=Sup	_	_	_	_
20	in	in	ADP	IN	_	_	_	_	_
21	part	part	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
22	,	,	PUNCT	,	_	_	_	_	_
23	by	by	ADP	IN	_	_	_	_	_
24	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
25	lack	lack	NOUN	NN	Number=Sing	_	_	_	_
26	of	of	ADP	IN	_	_	_	_	_
27	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
28	factors	factor	NOUN	NNS	Number=Plur	_	_	_	_
29	that	that	PRON	WDT	PronType=Rel	_	_	_	_
30	are	be	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
31	essential	essential	ADJ	JJ	Degree=Pos	_	_	_	_
32	for	for	SCONJ	IN	_	_	_	_	_
33	Ig	ig	VERB	VBG	VerbForm=Ger	_	_	_	_
34	gene	gene	ADJ	JJ	Degree=Pos	_	_	_	_
35	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
36	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1425
# text = These transcription factors are either not produced due to block of transcription of their respective genes (Oct-2, OBF-1, PU.1), or are rendered inactive posttranslationally (NF-kappa B, E47).
1	These	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
2	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
3	factors	factor	NOUN	NNS	Number=Plur	_	_	_	_
4	are	be	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
5	either	either	CCONJ	CC	_	_	_	_	_
6	not	not	PART	RB	_	_	_	_	_
7	produced	produce	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
8	due	due	ADP	IN	_	_	_	_	_
9	to	to	ADP	IN	_	_	_	_	_
10	block	block	NOUN	NN	Number=Sing	_	_	_	_
11	of	of	ADP	IN	_	_	_	_	_
12	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
13	of	of	ADP	IN	_	_	_	_	_
14	their	they	PRON	PRP$	Number=Plur|Person=3|Poss=Yes|PronType=Prs	_	_	_	_
15	respective	respective	ADJ	JJ	Degree=Pos	_	_	_	_
16	genes	gene	NOUN	NNS	Number=Plur	_	_	_	_
17	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
18	Oct	Oct	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
19	-2	-2	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
20	,	,	PUNCT	,	_	_	_	_	_
21	OBF	OBF	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
22	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
23	1	1	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
24	,	,	PUNCT	,	_	_	_	_	_
25	PU.1	PU.1	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
26	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
27	,	,	PUNCT	,	_	_	_	_	_
28	or	or	CCONJ	CC	_	_	_	_	_
29	are	be	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
30	rendered	render	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
31	inactive	inactive	ADJ	JJ	Degree=Pos	_	_	_	_
32	posttranslationally	posttranslationally	ADV	RB	_	_	_	_	_
33	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
34	NF	Nf	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
35	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
36	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_
37	B	b	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
38	,	,	PUNCT	,	_	_	_	_	_
39	E47	E47	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
40	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
41	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1426
# text = By isolating Daudi x
1	By	by	SCONJ	IN	_	_	_	_	_
2	isolating	isolate	VERB	VBG	VerbForm=Ger	_	_	_	_
3	Daudi	Daudi	PROPN	NNP	Number=Sing	_	_	_	_
4	x	x	NOUN	NN	Number=Sing	_	_	_	_

# sent_id = 1427
# text = HeLa heterokaryons a few hours after fusion, we have studied the initial fate of two B cell-specific transcription factors involved in Ig gene transcription, Oct-2 and NF-kappa B.
1	HeLa	HeLa	PROPN	NNP	Number=Sing	_	_	_	_
2	heterokaryons	heterokaryon	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
3	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
4	few	few	ADJ	JJ	Degree=Pos	_	_	_	_
5	hours	hour	NOUN	NNS	Number=Plur	_	_	_	_
6	after	after	ADP	IN	_	_	_	_	_
7	fusion	fusion	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
8	,	,	PUNCT	,	_	_	_	_	_
9	we	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
10	have	have	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
11	studied	studie	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
12	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
13	initial	initial	ADJ	JJ	Degree=Pos	_	_	_	_
14	fate	fate	NOUN	NN	Number=Sing	_	_	_	_
15	of	of	ADP	IN	_	_	_	_	_
16	two	two	NUM	CD	NumType=Card	_	_	_	_
17	B	b	ADJ	JJ	Degree=Pos	_	_	_	_
18	cell	cell	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
19	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
20	specific	specific	ADJ	JJ	Degree=Pos	_	_	_	_
21	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
22	factors	factor	NOUN	NNS	Number=Plur	_	_	_	_
23	involved	involved	ADJ	JJ	Degree=Pos	_	_	_	_
24	in	in	ADP	IN	_	_	_	_	_
25	Ig	ig	PROPN	NNP	Number=Sing	_	_	_	_
26	gene	gene	PROPN	NNP	Number=Sing	_	_	_	_
27	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
28	,	,	PUNCT	,	_	_	_	_	_
29	Oct	Oct	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
30	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
31	2	2	NUM	CD	NumType=Card	_	_	_	_
32	and	and	CCONJ	CC	_	_	_	_	_
33	NF	Nf	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
34	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
35	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_
36	B	b	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
37	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1428
# text = This report provides the first demonstration that upon fusion with HeLa cells, the nuclear contents of B cell-expressed transcription factors are depleted within a few hours with kinetics that are as fast or faster than that of Ig gene extinction.
1	This	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
2	report	report	NOUN	NN	Number=Sing	_	_	_	_
3	provides	provide	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
4	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
5	first	first	ADJ	JJ	Degree=Pos|NumType=Ord	_	_	_	_
6	demonstration	demonstration	NOUN	NN	Number=Sing	_	_	_	_
7	that	that	PRON	WDT	PronType=Rel	_	_	_	_
8	upon	upon	ADP	IN	_	_	_	_	_
9	fusion	fusion	NOUN	NN	Number=Sing	_	_	_	_
10	with	with	ADP	IN	_	_	_	_	_
11	HeLa	HeLa	PROPN	NNP	Number=Sing	_	_	_	_
12	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
13	,	,	PUNCT	,	_	_	_	_	_
14	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
15	nuclear	nuclear	ADJ	JJ	Degree=Pos	_	_	_	_
16	contents	contents	NOUN	NNS	Number=Plur	_	_	_	_
17	of	of	ADP	IN	_	_	_	_	_
18	B	b	NOUN	NN	Number=Sing	_	_	_	_
19	cell	cell	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
20	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
21	expressed	expressed	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
22	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
23	factors	factor	NOUN	NNS	Number=Plur	_	_	_	_
24	are	be	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
25	depleted	deplet	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
26	within	within	ADP	IN	_	_	_	_	_
27	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
28	few	few	ADJ	JJ	Degree=Pos	_	_	_	_
29	hours	hour	NOUN	NNS	Number=Plur	_	_	_	_
30	with	with	ADP	IN	_	_	_	_	_
31	kinetics	kinetic	NOUN	NNS	Number=Plur	_	_	_	_
32	that	that	PRON	WDT	PronType=Rel	_	_	_	_
33	are	be	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
34	as	as	ADV	RB	_	_	_	_	_
35	fast	fast	ADJ	JJ	Degree=Pos	_	_	_	_
36	or	or	CCONJ	CC	_	_	_	_	_
37	faster	faster	ADJ	JJR	Degree=Cmp	_	_	_	_
38	than	than	ADP	IN	_	_	_	_	_
39	that	that	PRON	DT	Number=Sing|PronType=Dem	_	_	_	_
40	of	of	ADP	IN	_	_	_	_	_
41	Ig	ig	ADJ	JJ	Degree=Pos	_	_	_	_
42	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
43	extinction	extinction	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
44	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1429
# text = Thus, the extinguishing mechanism is effective very early after fusion.
1	Thus	thus	ADV	RB	_	_	_	_	SpaceAfter=No
2	,	,	PUNCT	,	_	_	_	_	_
3	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
4	extinguishing	extinguishing	NOUN	NN	Number=Sing	_	_	_	_
5	mechanism	mechanism	NOUN	NN	Number=Sing	_	_	_	_
6	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
7	effective	effective	ADJ	JJ	Degree=Pos	_	_	_	_
8	very	very	ADV	RB	_	_	_	_	_
9	early	early	ADV	RB	Degree=Pos	_	_	_	_
10	after	after	ADP	IN	_	_	_	_	_
11	fusion	fusion	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
12	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1430
# text = We suggest that extinction of Ig genes is part of a global mechanism that suppresses the differentiation program foreign to the HeLa phenotype.
1	We	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
2	suggest	suggest	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
3	that	that	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
4	extinction	extinction	NOUN	NN	Number=Sing	_	_	_	_
5	of	of	ADP	IN	_	_	_	_	_
6	Ig	ig	ADJ	JJ	Degree=Pos	_	_	_	_
7	genes	gene	NOUN	NNS	Number=Plur	_	_	_	_
8	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
9	part	part	NOUN	NN	Number=Sing	_	_	_	_
10	of	of	ADP	IN	_	_	_	_	_
11	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
12	global	global	ADJ	JJ	Degree=Pos	_	_	_	_
13	mechanism	mechanism	NOUN	NN	Number=Sing	_	_	_	_
14	that	that	PRON	WDT	PronType=Rel	_	_	_	_
15	suppresses	suppress	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
16	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
17	differentiation	differentiation	NOUN	NN	Number=Sing	_	_	_	_
18	program	program	NOUN	NN	Number=Sing	_	_	_	_
19	foreign	foreign	ADJ	JJ	Degree=Pos	_	_	_	_
20	to	to	ADP	IN	_	_	_	_	_
21	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
22	HeLa	HeLa	PROPN	NNP	Number=Sing	_	_	_	_
23	phenotype	phenotype	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
24	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 1431
# text = Document 003002514 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	003002514	003002514	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 1432
# text = Sequential development of structural and functional alterations in T cells from tumor-bearing mice.
1	Sequential	Sequential	ADJ	JJ	Degree=Pos	_	_	_	_
2	development	development	NOUN	NN	Number=Sing	_	_	_	_
3	of	of	ADP	IN	_	_	_	_	_
4	structural	structural	ADJ	JJ	Degree=Pos	_	_	_	_
5	and	and	CCONJ	CC	_	_	_	_	_
6	functional	functional	ADJ	JJ	Degree=Pos	_	_	_	_
7	alterations	alteration	NOUN	NNS	Number=Plur	_	_	_	_
8	in	in	ADP	IN	_	_	_	_	_
9	T	t	PROPN	NNP	Number=Sing	_	_	_	_
10	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
11	from	from	ADP	IN	_	_	_	_	_
12	tumor	tumor	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
13	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
14	bearing	bearing	VERB	VBG	VerbForm=Ger	_	_	_	_
15	mice	mouse	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
16	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 1433
# text = The TCR alpha beta or -gamma delta chains bind the peptide ligand, whereas the associated CD3 deltaepsilongamma and TCR zeta subunits couple the TCR to intracellular signal transduction components.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	TCR	Tcr	NOUN	NN	Number=Sing	_	_	_	_
3	alpha	alpha	ADP	IN	_	_	_	_	_
4	beta	beta	NOUN	NN	Number=Sing	_	_	_	_
5	or	or	CCONJ	CC	_	_	_	_	_
6	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
7	gamma	gamma	NOUN	NN	Number=Sing	_	_	_	_
8	delta	delta	NOUN	NN	Number=Sing	_	_	_	_
9	chains	chain	NOUN	NNS	Number=Plur	_	_	_	_
10	bind	bind	ADP	IN	_	_	_	_	_
11	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
12	peptide	peptide	NOUN	NN	Number=Sing	_	_	_	_
13	ligand	ligand	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
14	,	,	PUNCT	,	_	_	_	_	_
15	whereas	whereas	SCONJ	IN	_	_	_	_	_
16	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
17	associated	associate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
18	CD3	CD3	NOUN	NN	Number=Sing	_	_	_	_
19	deltaepsilongamma	deltaepsilongamma	NOUN	NN	Number=Sing	_	_	_	_
20	and	and	CCONJ	CC	_	_	_	_	_
21	TCR	Tcr	NOUN	NN	Number=Sing	_	_	_	_
22	zeta	zeta	NOUN	NN	Number=Sing	_	_	_	_
23	subunits	subunit	NOUN	NNS	Number=Plur	_	_	_	_
24	couple	couple	NOUN	NN	Number=Sing	_	_	_	_
25	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
26	TCR	Tcr	NOUN	NN	Number=Sing	_	_	_	_
27	to	to	ADP	IN	_	_	_	_	_
28	intracellular	intracellular	ADJ	JJ	Degree=Pos	_	_	_	_
29	signal	signal	NOUN	NN	Number=Sing	_	_	_	_
30	transduction	transduction	NOUN	NN	Number=Sing	_	_	_	_
31	components	component	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
32	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1434
# text = Recently, several groups have described marked alterations in signal transduction elements in T cells from cancer patients or in mice bearing tumor for a few weeks (>26 days).
1	Recently	recently	ADV	RB	_	_	_	_	SpaceAfter=No
2	,	,	PUNCT	,	_	_	_	_	_
3	several	several	ADJ	JJ	Degree=Pos	_	_	_	_
4	groups	group	NOUN	NNS	Number=Plur	_	_	_	_
5	have	have	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
6	described	describe	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
7	marked	mark	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
8	alterations	alteration	NOUN	NNS	Number=Plur	_	_	_	_
9	in	in	ADP	IN	_	_	_	_	_
10	signal	signal	ADJ	JJ	Degree=Pos	_	_	_	_
11	transduction	transduction	NOUN	NN	Number=Sing	_	_	_	_
12	elements	element	NOUN	NNS	Number=Plur	_	_	_	_
13	in	in	ADP	IN	_	_	_	_	_
14	T	t	PROPN	NNP	Number=Sing	_	_	_	_
15	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
16	from	from	ADP	IN	_	_	_	_	_
17	cancer	cancer	NOUN	NN	Number=Sing	_	_	_	_
18	patients	patient	NOUN	NN	Number=Sing	_	_	_	_
19	or	or	CCONJ	CC	_	_	_	_	_
20	in	in	ADP	IN	_	_	_	_	_
21	mice	mouse	NOUN	NNS	Number=Plur	_	_	_	_
22	bearing	bear	VERB	VBG	VerbForm=Ger	_	_	_	_
23	tumor	tumor	NOUN	NN	Number=Sing	_	_	_	_
24	for	for	ADP	IN	_	_	_	_	_
25	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
26	few	few	ADJ	JJ	Degree=Pos	_	_	_	_
27	weeks	week	NOUN	NNS	Number=Plur	_	_	_	_
28	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
29	>26	>26	NUM	CD	NumType=Card	_	_	_	_
30	days	day	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
31	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
32	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1435
# text = The sequence in which these alterations develop is unknown.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	sequence	sequence	NOUN	NN	Number=Sing	_	_	_	_
3	in	in	ADP	IN	_	_	_	_	_
4	which	which	PRON	WDT	PronType=Rel	_	_	_	_
5	these	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
6	alterations	alteration	NOUN	NNS	Number=Plur	_	_	_	_
7	develop	develop	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
8	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
9	unknown	unknown	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
10	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1436
# text = The aim of this study was to explore the kinetics of the development of alterations in signal transduction molecules (TCR zeta chain, NF kappaB family proteins, and tyrosine kinase p56(lck)) in mice bearing MC38 colon adenocarcinoma.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	aim	aim	NOUN	NN	Number=Sing	_	_	_	_
3	of	of	ADP	IN	_	_	_	_	_
4	this	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
5	study	study	NOUN	NN	Number=Sing	_	_	_	_
6	was	be	VERB	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
7	to	to	PART	TO	_	_	_	_	_
8	explore	explore	VERB	VB	VerbForm=Inf	_	_	_	_
9	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
10	kinetics	kinetic	NOUN	NNS	Number=Plur	_	_	_	_
11	of	of	ADP	IN	_	_	_	_	_
12	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
13	development	development	NOUN	NN	Number=Sing	_	_	_	_
14	of	of	ADP	IN	_	_	_	_	_
15	alterations	alteration	NOUN	NNS	Number=Plur	_	_	_	_
16	in	in	ADP	IN	_	_	_	_	_
17	signal	signal	ADJ	JJ	Degree=Pos	_	_	_	_
18	transduction	transduction	NOUN	NN	Number=Sing	_	_	_	_
19	molecules	molecule	NOUN	NNS	Number=Plur	_	_	_	_
20	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
21	TCR	Tcr	NOUN	NN	Number=Sing	_	_	_	_
22	zeta	zeta	NOUN	NN	Number=Sing	_	_	_	_
23	chain	chain	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
24	,	,	PUNCT	,	_	_	_	_	_
25	NF	NF	PROPN	NNP	Number=Sing	_	_	_	_
26	kappaB	kappaB	PROPN	NNP	Number=Sing	_	_	_	_
27	family	family	NOUN	NN	Number=Sing	_	_	_	_
28	proteins	protein	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
29	,	,	PUNCT	,	_	_	_	_	_
30	and	and	CCONJ	CC	_	_	_	_	_
31	tyrosine	tyrosine	NOUN	NN	Number=Sing	_	_	_	_
32	kinase	kinase	NOUN	NN	Number=Sing	_	_	_	_
33	p56	p56	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
34	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
35	lck	lck	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
36	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
37	)	)	PUNCT	-RRB-	_	_	_	_	_
38	in	in	ADP	IN	_	_	_	_	_
39	mice	mouse	NOUN	NNS	Number=Plur	_	_	_	_
40	bearing	bear	VERB	VBG	VerbForm=Ger	_	_	_	_
41	MC38	MC38	NUM	CD	NumType=Card	_	_	_	_
42	colon	colon	NOUN	NN	Number=Sing	_	_	_	_
43	adenocarcinoma	adenocarcinoma	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
44	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1437
# text = The results demonstrate that alterations in NF kappaB family proteins, specifically the failure of p65 translocation to the nucleus, occur earlier and more frequently than the decrease in zeta-chain.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	results	result	NOUN	NNS	Number=Plur	_	_	_	_
3	demonstrate	demonstrate	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
4	that	that	SCONJ	IN	_	_	_	_	_
5	alterations	alteration	NOUN	NNS	Number=Plur	_	_	_	_
6	in	in	ADP	IN	_	_	_	_	_
7	NF	NF	PROPN	NNP	Number=Sing	_	_	_	_
8	kappaB	kappaB	PROPN	NNP	Number=Sing	_	_	_	_
9	family	family	NOUN	NN	Number=Sing	_	_	_	_
10	proteins	protein	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
11	,	,	PUNCT	,	_	_	_	_	_
12	specifically	specifically	ADV	RB	_	_	_	_	_
13	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
14	failure	failure	NOUN	NN	Number=Sing	_	_	_	_
15	of	of	ADP	IN	_	_	_	_	_
16	p65	p65	NUM	CD	NumType=Card	_	_	_	_
17	translocation	translocation	NOUN	NN	Number=Sing	_	_	_	_
18	to	to	ADP	IN	_	_	_	_	_
19	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
20	nucleus	nucleus	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
21	,	,	PUNCT	,	_	_	_	_	_
22	occur	occur	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
23	earlier	earlier	ADV	RBR	Degree=Cmp	_	_	_	_
24	and	and	CCONJ	CC	_	_	_	_	_
25	more	more	ADV	RBR	_	_	_	_	_
26	frequently	frequently	ADV	RB	_	_	_	_	_
27	than	than	ADP	IN	_	_	_	_	_
28	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
29	decrease	decrease	NOUN	NN	Number=Sing	_	_	_	_
30	in	in	ADP	IN	_	_	_	_	_
31	zeta	zeta	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
32	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
33	chain	chain	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
34	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1438
# text = These defects are paralleled by an impaired ability to produce Th1 cytokines (IL-2 and IFN-gamma).
1	These	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
2	defects	defects	NOUN	NNS	Number=Plur	_	_	_	_
3	are	be	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
4	paralleled	parallel	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
5	by	by	ADP	IN	_	_	_	_	_
6	an	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
7	impaired	impaire	ADJ	JJ	Degree=Pos	_	_	_	_
8	ability	ability	NOUN	NN	Number=Sing	_	_	_	_
9	to	to	PART	TO	_	_	_	_	_
10	produce	produce	VERB	VB	VerbForm=Inf	_	_	_	_
11	Th1	Th1	NUM	CD	NumType=Card	_	_	_	_
12	cytokines	cytokine	NOUN	NNS	Number=Plur	_	_	_	_
13	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
14	IL	Il	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
15	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
16	2	2	NUM	CD	NumType=Card	_	_	_	_
17	and	and	CCONJ	CC	_	_	_	_	_
18	IFN	Ifn	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
19	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
20	gamma	gamma	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
21	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
22	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1439
# text = These initial changes are followed by the eventual loss of TCR zeta chain and p56(lck) and a marked decrease in cytotoxic function.
1	These	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
2	initial	initial	ADJ	JJ	Degree=Pos	_	_	_	_
3	changes	change	NOUN	NNS	Number=Plur	_	_	_	_
4	are	be	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
5	followed	follow	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
6	by	by	ADP	IN	_	_	_	_	_
7	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
8	eventual	eventual	ADJ	JJ	Degree=Pos	_	_	_	_
9	loss	loss	NOUN	NN	Number=Sing	_	_	_	_
10	of	of	ADP	IN	_	_	_	_	_
11	TCR	Tcr	NOUN	NN	Number=Sing	_	_	_	_
12	zeta	zeta	NOUN	NN	Number=Sing	_	_	_	_
13	chain	chain	NOUN	NN	Number=Sing	_	_	_	_
14	and	and	CCONJ	CC	_	_	_	_	_
15	p56	p56	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
16	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
17	lck	lck	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
18	)	)	PUNCT	-RRB-	_	_	_	_	_
19	and	and	CCONJ	CC	_	_	_	_	_
20	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
21	marked	mark	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
22	decrease	decrease	NOUN	NN	Number=Sing	_	_	_	_
23	in	in	ADP	IN	_	_	_	_	_
24	cytotoxic	cytotoxic	ADJ	JJ	Degree=Pos	_	_	_	_
25	function	function	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
26	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1440
# text = An increased rate of lysosomal degradation is one of the mechanisms responsible for the loss of zeta-chain.
1	An	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
2	increased	increase	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
3	rate	rate	NOUN	NN	Number=Sing	_	_	_	_
4	of	of	ADP	IN	_	_	_	_	_
5	lysosomal	lysosomal	ADJ	JJ	Degree=Pos	_	_	_	_
6	degradation	degradation	NOUN	NN	Number=Sing	_	_	_	_
7	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
8	one	one	NUM	CD	NumType=Card	_	_	_	_
9	of	of	ADP	IN	_	_	_	_	_
10	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
11	mechanisms	mechanism	NOUN	NNS	Number=Plur	_	_	_	_
12	responsible	responsible	ADJ	JJ	Degree=Pos	_	_	_	_
13	for	for	ADP	IN	_	_	_	_	_
14	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
15	loss	loss	NOUN	NN	Number=Sing	_	_	_	_
16	of	of	ADP	IN	_	_	_	_	_
17	zeta	zeta	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
18	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
19	chain	chain	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
20	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 1441
# text = Document 003002520 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	003002520	003002520	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 1442
# text = Thymocytes control the CD4 gene differently from mature T lymphocytes.
1	Thymocytes	Thymocyte	NOUN	NNS	Number=Plur	_	_	_	_
2	control	control	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
3	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
4	CD4	CD4	PROPN	NNP	Number=Sing	_	_	_	_
5	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
6	differently	differently	ADV	RB	_	_	_	_	_
7	from	from	ADP	IN	_	_	_	_	_
8	mature	mature	ADJ	JJ	Degree=Pos	_	_	_	_
9	T	t	PROPN	NNP	Number=Sing	_	_	_	_
10	lymphocytes	lymphocyte	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
11	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 1443
# text = We analyzed the activity of the enhancer, the promoter and the silencer of the human CD4 gene during T cell development using transgenic mice.
1	We	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
2	analyzed	analyze	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
3	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
4	activity	activity	NOUN	NN	Number=Sing	_	_	_	_
5	of	of	ADP	IN	_	_	_	_	_
6	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
7	enhancer	enhancer	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
8	,	,	PUNCT	,	_	_	_	_	_
9	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
10	promoter	promoter	NOUN	NN	Number=Sing	_	_	_	_
11	and	and	CCONJ	CC	_	_	_	_	_
12	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
13	silencer	silencer	NOUN	NN	Number=Sing	_	_	_	_
14	of	of	ADP	IN	_	_	_	_	_
15	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
16	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
17	CD4	Cd4	NOUN	NN	Number=Sing	_	_	_	_
18	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
19	during	during	ADP	IN	_	_	_	_	_
20	T	t	PROPN	NNP	Number=Sing	_	_	_	_
21	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
22	development	development	NOUN	NN	Number=Sing	_	_	_	_
23	using	use	VERB	VBG	VerbForm=Ger	_	_	_	_
24	transgenic	transgenic	ADJ	JJ	Degree=Pos	_	_	_	_
25	mice	mouse	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
26	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1444
# text = Immunofluorescence studies on thymic populations of mice carrying transgenes in various combinations of these regulatory DNA elements revealed that thymocytes control the CD4 gene in a different manner than mature peripheral T lymphocytes.
1	Immunofluorescence	Immunofluorescence	NOUN	NN	Number=Sing	_	_	_	_
2	studies	study	NOUN	NNS	Number=Plur	_	_	_	_
3	on	on	ADP	IN	_	_	_	_	_
4	thymic	thymic	ADJ	JJ	Degree=Pos	_	_	_	_
5	populations	population	NOUN	NNS	Number=Plur	_	_	_	_
6	of	of	ADP	IN	_	_	_	_	_
7	mice	mouse	NOUN	NNS	Number=Plur	_	_	_	_
8	carrying	carry	VERB	VBG	VerbForm=Ger	_	_	_	_
9	transgenes	transgene	NOUN	NNS	Number=Plur	_	_	_	_
10	in	in	ADP	IN	_	_	_	_	_
11	various	various	ADJ	JJ	Degree=Pos	_	_	_	_
12	combinations	combination	NOUN	NNS	Number=Plur	_	_	_	_
13	of	of	ADP	IN	_	_	_	_	_
14	these	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
15	regulatory	regulatory	ADJ	JJ	Degree=Pos	_	_	_	_
16	DNA	dna	NOUN	NN	Number=Sing	_	_	_	_
17	elements	element	NOUN	NNS	Number=Plur	_	_	_	_
18	revealed	reveal	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
19	that	that	SCONJ	IN	_	_	_	_	_
20	thymocytes	thymocyte	NOUN	NNS	Number=Plur	_	_	_	_
21	control	control	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
22	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
23	CD4	CD4	PROPN	NNP	Number=Sing	_	_	_	_
24	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
25	in	in	ADP	IN	_	_	_	_	_
26	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
27	different	different	ADJ	JJ	Degree=Pos	_	_	_	_
28	manner	manner	NOUN	NN	Number=Sing	_	_	_	_
29	than	than	ADP	IN	_	_	_	_	_
30	mature	mature	ADJ	JJ	Degree=Pos	_	_	_	_
31	peripheral	peripheral	ADJ	JJ	Degree=Pos	_	_	_	_
32	T	t	NOUN	NN	Number=Sing	_	_	_	_
33	lymphocytes	lymphocyte	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
34	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1445
# text = The 5'-positive regulatory unit, consisting of the promoter and the 5' enhancer, is already active at the CD4-CD8-double-negative (DN) stage of development.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	5	5	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
3	'	'	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	-	-	PUNCT	:	_	_	_	_	SpaceAfter=No
5	positive	positive	ADJ	JJ	Degree=Pos	_	_	_	_
6	regulatory	regulatory	ADJ	JJ	Degree=Pos	_	_	_	_
7	unit	unit	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
8	,	,	PUNCT	,	_	_	_	_	_
9	consisting	consisting	VERB	VBG	VerbForm=Ger	_	_	_	_
10	of	of	ADP	IN	_	_	_	_	_
11	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
12	promoter	promoter	NOUN	NN	Number=Sing	_	_	_	_
13	and	and	CCONJ	CC	_	_	_	_	_
14	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
15	5	5	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
16	'	's	PUNCT	``	_	_	_	_	_
17	enhancer	enhancer	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
18	,	,	PUNCT	,	_	_	_	_	_
19	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
20	already	already	ADV	RB	_	_	_	_	_
21	active	active	ADJ	JJ	Degree=Pos	_	_	_	_
22	at	at	ADP	IN	_	_	_	_	_
23	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
24	CD4-CD8	CD4-CD8	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
25	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
26	double	double	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
27	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
28	negative	negative	ADJ	JJ	Degree=Pos	_	_	_	_
29	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
30	DN	DN	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
31	)	)	PUNCT	-RRB-	_	_	_	_	_
32	stage	stage	NOUN	NN	Number=Sing	_	_	_	_
33	of	of	ADP	IN	_	_	_	_	_
34	development	development	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
35	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1446
# text = However, its activity becomes lower in the double-positive and a fraction of the CD4+ CD8int/- cell population, indicating that an additional enhancer, located in either the first or the third intron of the CD4 gene, is required for CD4 gene expression in this population.
1	However	however	ADV	RB	_	_	_	_	SpaceAfter=No
2	,	,	PUNCT	,	_	_	_	_	_
3	it	it	PRON	PRP	Case=Nom|Gender=Neut|Number=Sing|Person=3|PronType=Prs	_	_	_	SpaceAfter=No
4	s	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
5	activity	activity	NOUN	NN	Number=Sing	_	_	_	_
6	becomes	become	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
7	lower	lower	ADJ	JJR	Degree=Cmp	_	_	_	_
8	in	in	ADP	IN	_	_	_	_	_
9	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
10	double	double	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
11	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
12	positive	positive	ADJ	JJ	Degree=Pos	_	_	_	_
13	and	and	CCONJ	CC	_	_	_	_	_
14	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
15	fraction	fraction	NOUN	NN	Number=Sing	_	_	_	_
16	of	of	ADP	IN	_	_	_	_	_
17	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
18	CD4	CD4	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
19	+	+	SYM	SYM	_	_	_	_	_
20	CD8int	CD8int	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
21	/-	/-	PUNCT	.	_	_	_	_	_
22	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
23	population	population	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
24	,	,	PUNCT	,	_	_	_	_	_
25	indicating	indicate	VERB	VBG	VerbForm=Ger	_	_	_	_
26	that	that	SCONJ	IN	_	_	_	_	_
27	an	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
28	additional	additional	ADJ	JJ	Degree=Pos	_	_	_	_
29	enhancer	enhancer	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
30	,	,	PUNCT	,	_	_	_	_	_
31	located	locate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
32	in	in	ADP	IN	_	_	_	_	_
33	either	either	CCONJ	CC	_	_	_	_	_
34	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
35	first	first	ADJ	JJ	Degree=Pos|NumType=Ord	_	_	_	_
36	or	or	CCONJ	CC	_	_	_	_	_
37	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
38	third	third	ADJ	JJ	Degree=Pos|NumType=Ord	_	_	_	_
39	intron	intron	NOUN	NN	Number=Sing	_	_	_	_
40	of	of	ADP	IN	_	_	_	_	_
41	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
42	CD4	CD4	PROPN	NNP	Number=Sing	_	_	_	_
43	gene	gene	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
44	,	,	PUNCT	,	_	_	_	_	_
45	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
46	required	require	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
47	for	for	ADP	IN	_	_	_	_	_
48	CD4	CD4	NUM	CD	NumType=Card	_	_	_	_
49	gene	gene	ADJ	JJ	Degree=Pos	_	_	_	_
50	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
51	in	in	ADP	IN	_	_	_	_	_
52	this	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
53	population	population	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
54	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1447
# text = The other studied regulatory element is the minimal CD4 silencer which inhibits CD4 gene expression in peripheral CD8 T lymphocytes.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	other	other	ADJ	JJ	Degree=Pos	_	_	_	_
3	studied	study	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
4	regulatory	regulatory	ADJ	JJ	Degree=Pos	_	_	_	_
5	element	element	NOUN	NN	Number=Sing	_	_	_	_
6	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
7	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
8	minimal	minimal	ADJ	JJ	Degree=Pos	_	_	_	_
9	CD4	Cd4	NOUN	NN	Number=Sing	_	_	_	_
10	silencer	silencer	NOUN	NN	Number=Sing	_	_	_	_
11	which	which	PRON	WDT	PronType=Rel	_	_	_	_
12	inhibits	inhibits	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
13	CD4	CD4	NUM	CD	NumType=Card	_	_	_	_
14	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
15	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
16	in	in	ADP	IN	_	_	_	_	_
17	peripheral	peripheral	ADJ	JJ	Degree=Pos	_	_	_	_
18	CD8	CD8	PROPN	NNP	Number=Sing	_	_	_	_
19	T	t	PROPN	NNP	Number=Sing	_	_	_	_
20	lymphocytes	lymphocyte	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
21	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1448
# text = This silencer is inactive in the most immature DN thymocytes, which probably use a distinct silencer mechanism to down-regulate CD4 gene expression.
1	This	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
2	silencer	silencer	NOUN	NN	Number=Sing	_	_	_	_
3	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
4	inactive	inactive	ADJ	JJ	Degree=Pos	_	_	_	_
5	in	in	ADP	IN	_	_	_	_	_
6	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
7	most	most	ADV	RBS	_	_	_	_	_
8	immature	immature	ADJ	JJ	Degree=Pos	_	_	_	_
9	DN	Dn	NOUN	NN	Number=Sing	_	_	_	_
10	thymocytes	thymocyte	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
11	,	,	PUNCT	,	_	_	_	_	_
12	which	which	PRON	WDT	PronType=Rel	_	_	_	_
13	probably	probably	ADV	RB	_	_	_	_	_
14	use	use	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
15	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
16	distinct	distinct	ADJ	JJ	Degree=Pos	_	_	_	_
17	silencer	silencer	NOUN	NN	Number=Sing	_	_	_	_
18	mechanism	mechanism	NOUN	NN	Number=Sing	_	_	_	_
19	to	to	ADP	IN	_	_	_	_	_
20	down	down	ADV	RB	_	_	_	_	SpaceAfter=No
21	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
22	regulate	regulate	ADJ	JJ	Degree=Pos	_	_	_	_
23	CD4	Cd4	NOUN	NN	Number=Sing	_	_	_	_
24	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
25	expression	expression	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
26	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1449
# text = Unexpectedly, the CD4 silencer is also active in CD4+ CD8int/- cells of the thymus, implying that an anti-silencer may be required to resume CD4 expression in this cell population.
1	Unexpectedly	unexpectedly	ADV	RB	_	_	_	_	SpaceAfter=No
2	,	,	PUNCT	,	_	_	_	_	_
3	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
4	CD4	CD4	PROPN	NNP	Number=Sing	_	_	_	_
5	silencer	silencer	NOUN	NN	Number=Sing	_	_	_	_
6	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
7	also	also	ADV	RB	_	_	_	_	_
8	active	active	ADJ	JJ	Degree=Pos	_	_	_	_
9	in	in	ADP	IN	_	_	_	_	_
10	CD4	CD4	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
11	+	+	SYM	SYM	_	_	_	_	_
12	CD8int	CD8int	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
13	/-	/-	PUNCT	.	_	_	_	_	_
14	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
15	of	of	ADP	IN	_	_	_	_	_
16	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
17	thymus	thymus	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
18	,	,	PUNCT	,	_	_	_	_	_
19	implying	imply	VERB	VBG	VerbForm=Ger	_	_	_	_
20	that	that	SCONJ	IN	_	_	_	_	_
21	an	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
22	anti-silencer	anti-silencer	NOUN	NN	Number=Sing	_	_	_	_
23	may	may	AUX	MD	VerbForm=Fin	_	_	_	_
24	be	be	AUX	VB	VerbForm=Inf	_	_	_	_
25	required	require	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
26	to	to	PART	TO	_	_	_	_	_
27	resume	resume	VERB	VB	VerbForm=Inf	_	_	_	_
28	CD4	CD4	NUM	CD	NumType=Card	_	_	_	_
29	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
30	in	in	ADP	IN	_	_	_	_	_
31	this	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
32	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
33	population	population	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
34	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1450
# text = Altogether, the CD4 gene is regulated by several positive and negative regulatory mechanisms which come into play in a developmentally coordinated manner.
1	Altogether	altogether	ADV	RB	_	_	_	_	SpaceAfter=No
2	,	,	PUNCT	,	_	_	_	_	_
3	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
4	CD4	CD4	PROPN	NNP	Number=Sing	_	_	_	_
5	gene	gene	PROPN	NNP	Number=Sing	_	_	_	_
6	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
7	regulated	regulate	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
8	by	by	ADP	IN	_	_	_	_	_
9	several	several	ADJ	JJ	Degree=Pos	_	_	_	_
10	positive	positive	ADJ	JJ	Degree=Pos	_	_	_	_
11	and	and	CCONJ	CC	_	_	_	_	_
12	negative	negative	ADJ	JJ	Degree=Pos	_	_	_	_
13	regulatory	regulatory	ADJ	JJ	Degree=Pos	_	_	_	_
14	mechanisms	mechanism	NOUN	NNS	Number=Plur	_	_	_	_
15	which	which	PRON	WDT	PronType=Rel	_	_	_	_
16	come	come	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
17	into	into	ADP	IN	_	_	_	_	_
18	play	play	NOUN	NN	Number=Sing	_	_	_	_
19	in	in	ADP	IN	_	_	_	_	_
20	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
21	developmentally	developmentally	ADV	RB	_	_	_	_	_
22	coordinated	coordinate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
23	manner	manner	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
24	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 1451
# text = Document 003002530 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	003002530	003002530	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 1452
# text = Globin gene switching.
1	Globin	Globin	PROPN	NNP	Number=Sing	_	_	_	_
2	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
3	switching	switching	VERB	VBG	Tense=Pres|VerbForm=Part	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1453
# text = In vivo protein-DNA interactions of the human beta-globin locus in erythroid cells expressing the fetal or the adult globin gene program.
1	In	in	ADP	IN	_	_	_	_	_
2	vivo	vivo	NOUN	NN	Number=Sing	_	_	_	_
3	protein	protein	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
4	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
5	DNA	dna	NOUN	NN	Number=Sing	_	_	_	_
6	interactions	interaction	NOUN	NNS	Number=Plur	_	_	_	_
7	of	of	ADP	IN	_	_	_	_	_
8	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
9	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
10	beta	beta	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
11	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
12	globin	globin	NOUN	NN	Number=Sing	_	_	_	_
13	locus	locus	NOUN	NN	Number=Sing	_	_	_	_
14	in	in	ADP	IN	_	_	_	_	_
15	erythroid	erythroid	ADJ	JJ	Degree=Pos	_	_	_	_
16	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
17	expressing	express	VERB	VBG	VerbForm=Ger	_	_	_	_
18	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
19	fetal	fetal	ADJ	JJ	Degree=Pos	_	_	_	_
20	or	or	CCONJ	CC	_	_	_	_	_
21	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
22	adult	adult	ADJ	JJ	Degree=Pos	_	_	_	_
23	globin	globin	NOUN	NN	Number=Sing	_	_	_	_
24	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
25	program	program	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
26	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 1454
# text = To characterize the protein-DNA interactions important for the developmental control of the human beta-globin locus, we analyzed by in vivo dimethyl sulfate footprinting erythroid cells expressing either the fetal or the adult globin developmental program.
1	To	to	PART	TO	_	_	_	_	_
2	characterize	characterize	VERB	VB	VerbForm=Inf	_	_	_	_
3	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
4	protein	protein	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
5	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
6	DNA	dna	NOUN	NN	Number=Sing	_	_	_	_
7	interactions	interaction	NOUN	NNS	Number=Plur	_	_	_	_
8	important	important	ADJ	JJ	Degree=Pos	_	_	_	_
9	for	for	ADP	IN	_	_	_	_	_
10	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
11	developmental	developmental	ADJ	JJ	Degree=Pos	_	_	_	_
12	control	control	NOUN	NN	Number=Sing	_	_	_	_
13	of	of	ADP	IN	_	_	_	_	_
14	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
15	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
16	beta	beta	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
17	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
18	globin	globin	NOUN	NN	Number=Sing	_	_	_	_
19	locus	locus	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
20	,	,	PUNCT	,	_	_	_	_	_
21	we	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
22	analyzed	analyze	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
23	by	by	ADP	IN	_	_	_	_	_
24	in	in	ADP	IN	_	_	_	_	_
25	vivo	vivo	NOUN	NN	Number=Sing	_	_	_	_
26	dimethyl	dimethyl	NOUN	NN	Number=Sing	_	_	_	_
27	sulfate	sulfate	NOUN	NN	Number=Sing	_	_	_	_
28	footprinting	footprint	VERB	VBG	VerbForm=Ger	_	_	_	_
29	erythroid	erythroid	ADJ	JJ	Degree=Pos	_	_	_	_
30	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
31	expressing	expresse	VERB	VBG	VerbForm=Ger	_	_	_	_
32	either	either	CCONJ	CC	_	_	_	_	_
33	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
34	fetal	fetal	ADJ	JJ	Degree=Pos	_	_	_	_
35	or	or	CCONJ	CC	_	_	_	_	_
36	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
37	adult	adult	NOUN	NN	Number=Sing	_	_	_	_
38	globin	globin	ADP	IN	_	_	_	_	_
39	developmental	developmental	ADJ	JJ	Degree=Pos	_	_	_	_
40	program	program	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
41	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1455
# text = In the locus control region (LCR) of the beta-globin locus, in vivo footprints on NF-E2 (or AP-1) and GATA-1 motifs remained the same regardless of whether the fetal or the adult globin genes are expressed.
1	In	in	ADP	IN	_	_	_	_	_
2	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
3	locus	locus	NOUN	NN	Number=Sing	_	_	_	_
4	control	control	NOUN	NN	Number=Sing	_	_	_	_
5	region	region	NOUN	NN	Number=Sing	_	_	_	_
6	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
7	LCR	LCR	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
8	)	)	PUNCT	-RRB-	_	_	_	_	_
9	of	of	ADP	IN	_	_	_	_	_
10	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
11	beta	beta	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
12	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
13	globin	globin	NOUN	NN	Number=Sing	_	_	_	_
14	locus	locus	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
15	,	,	PUNCT	,	_	_	_	_	_
16	in	in	ADP	IN	_	_	_	_	_
17	vivo	vivo	ADJ	JJ	Degree=Pos	_	_	_	_
18	footprints	footprint	NOUN	NNS	Number=Plur	_	_	_	_
19	on	on	ADP	IN	_	_	_	_	_
20	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
21	-E2	-E2	NUM	CD	NumType=Card	_	_	_	_
22	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
23	or	or	CCONJ	CC	_	_	_	_	_
24	AP	ap	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
25	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
26	1	1	X	LS	_	_	_	_	SpaceAfter=No
27	)	)	PUNCT	-RRB-	_	_	_	_	_
28	and	and	CCONJ	CC	_	_	_	_	_
29	GATA	GATA	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
30	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
31	1	1	NUM	CD	NumType=Card	_	_	_	_
32	motifs	motif	NOUN	NNS	Number=Plur	_	_	_	_
33	remained	remain	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
34	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
35	same	same	ADJ	JJ	Degree=Pos	_	_	_	_
36	regardless	regardless	ADV	RB	_	_	_	_	_
37	of	of	SCONJ	IN	_	_	_	_	_
38	whether	whether	SCONJ	IN	_	_	_	_	_
39	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
40	fetal	fetal	ADJ	JJ	Degree=Pos	_	_	_	_
41	or	or	CCONJ	CC	_	_	_	_	_
42	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
43	adult	adult	ADJ	JJ	Degree=Pos	_	_	_	_
44	globin	globin	NOUN	NN	Number=Sing	_	_	_	_
45	genes	gene	NOUN	NNS	Number=Plur	_	_	_	_
46	are	be	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
47	expressed	expressed	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
48	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1456
# text = In contrast, in vivo footprints on GT (CACCC) motifs differed between the cells expressing the fetal or the adult globin program.
1	In	in	ADP	IN	_	_	_	_	_
2	contrast	contrast	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
3	,	,	PUNCT	,	_	_	_	_	_
4	in	in	ADP	IN	_	_	_	_	_
5	vivo	vivo	ADJ	JJ	Degree=Pos	_	_	_	_
6	footprints	footprint	NOUN	NNS	Number=Plur	_	_	_	_
7	on	on	ADP	IN	_	_	_	_	_
8	GT	GT	PROPN	NNP	Number=Sing	_	_	_	_
9	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
10	CACCC	CACCC	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
11	)	)	PUNCT	-RRB-	_	_	_	_	_
12	motifs	motif	NOUN	NNS	Number=Plur	_	_	_	_
13	differed	differ	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
14	between	between	ADP	IN	_	_	_	_	_
15	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
16	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
17	expressing	express	VERB	VBG	VerbForm=Ger	_	_	_	_
18	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
19	fetal	fetal	ADJ	JJ	Degree=Pos	_	_	_	_
20	or	or	CCONJ	CC	_	_	_	_	_
21	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
22	adult	adult	ADJ	JJ	Degree=Pos	_	_	_	_
23	globin	globin	NOUN	NN	Number=Sing	_	_	_	_
24	program	program	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
25	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1457
# text = In promoter regions, the actively transcribed genes demonstrated extensive and consistent footprints over the canonical elements, such as CACCC and CCAAT motifs.
1	In	in	ADP	IN	_	_	_	_	_
2	promoter	promoter	ADJ	JJ	Degree=Pos	_	_	_	_
3	regions	region	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	,	,	PUNCT	,	_	_	_	_	_
5	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
6	actively	actively	ADV	RB	_	_	_	_	_
7	transcribed	transcribe	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
8	genes	gene	NOUN	NNS	Number=Plur	_	_	_	_
9	demonstrated	demonstrate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
10	extensive	extensive	ADJ	JJ	Degree=Pos	_	_	_	_
11	and	and	CCONJ	CC	_	_	_	_	_
12	consistent	consistent	ADJ	JJ	Degree=Pos	_	_	_	_
13	footprints	footprint	NOUN	NNS	Number=Plur	_	_	_	_
14	over	over	ADP	IN	_	_	_	_	_
15	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
16	canonical	canonical	ADJ	JJ	Degree=Pos	_	_	_	_
17	elements	element	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
18	,	,	PUNCT	,	_	_	_	_	_
19	such	such	ADJ	JJ	Degree=Pos	_	_	_	_
20	as	as	ADP	IN	_	_	_	_	_
21	CACCC	CACCC	PROPN	NNP	Number=Sing	_	_	_	_
22	and	and	CCONJ	CC	_	_	_	_	_
23	CCAAT	Ccaat	ADJ	JJ	Degree=Pos	_	_	_	_
24	motifs	motif	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
25	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1458
# text = The adult globin expressing cells displayed more extensive footprints than the fetal globin expressing cells in the 3' regulatory sequences of both the Agamma- and the beta-globin genes, suggesting a role of these 3' elements in beta-globin gene expression.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	adult	adult	NOUN	NN	Number=Sing	_	_	_	_
3	globin	globin	NOUN	NN	Number=Sing	_	_	_	_
4	expressing	express	VERB	VBG	VerbForm=Ger	_	_	_	_
5	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
6	displayed	display	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
7	more	more	ADV	RBR	_	_	_	_	_
8	extensive	extensive	ADJ	JJ	Degree=Pos	_	_	_	_
9	footprints	footprint	NOUN	NNS	Number=Plur	_	_	_	_
10	than	than	ADP	IN	_	_	_	_	_
11	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
12	fetal	fetal	ADJ	JJ	Degree=Pos	_	_	_	_
13	globin	globin	NOUN	NN	Number=Sing	_	_	_	_
14	expressing	expresse	VERB	VBG	VerbForm=Ger	_	_	_	_
15	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
16	in	in	ADP	IN	_	_	_	_	_
17	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
18	3	3	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
19	'	'	PUNCT	``	_	_	_	_	_
20	regulatory	regulatory	ADJ	JJ	Degree=Pos	_	_	_	_
21	sequences	sequence	NOUN	NNS	Number=Plur	_	_	_	_
22	of	of	ADP	IN	_	_	_	_	_
23	both	both	CCONJ	CC	_	_	_	_	_
24	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
25	Agamma	Agamma	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
26	-	-	PUNCT	,	_	_	_	_	_
27	and	and	CCONJ	CC	_	_	_	_	_
28	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
29	beta	beta	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
30	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
31	globin	globin	NOUN	NN	Number=Sing	_	_	_	_
32	genes	gene	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
33	,	,	PUNCT	,	_	_	_	_	_
34	suggesting	suggest	VERB	VBG	VerbForm=Ger	_	_	_	_
35	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
36	role	role	NOUN	NN	Number=Sing	_	_	_	_
37	of	of	ADP	IN	_	_	_	_	_
38	these	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
39	3	3	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
40	'	'	PUNCT	''	_	_	_	_	_
41	elements	element	NOUN	NNS	Number=Plur	_	_	_	_
42	in	in	ADP	IN	_	_	_	_	_
43	beta	beta	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
44	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
45	globin	globin	NOUN	NN	Number=Sing	_	_	_	_
46	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
47	expression	expression	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
48	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1459
# text = Our results suggest that the bulk of protein-DNA interactions that underlies the developmental control of globin genes takes place in the gamma- and beta-globin gene promoters, and that GT motifs of the beta-globin locus LCR may play a role in the developmental regulation of human beta-globin gene expression, perhaps by increasing the probability of interaction of the LCR holocomplex with the fetal or the adult globin gene.
1	Our	we	PRON	PRP$	Number=Plur|Person=1|Poss=Yes|PronType=Prs	_	_	_	_
2	results	result	NOUN	NNS	Number=Plur	_	_	_	_
3	suggest	suggest	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
4	that	that	SCONJ	IN	_	_	_	_	_
5	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
6	bulk	bulk	NOUN	NN	Number=Sing	_	_	_	_
7	of	of	ADP	IN	_	_	_	_	_
8	protein	protein	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
9	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
10	DNA	dna	NOUN	NN	Number=Sing	_	_	_	_
11	interactions	interaction	NOUN	NNS	Number=Plur	_	_	_	_
12	that	that	PRON	WDT	PronType=Rel	_	_	_	_
13	underlies	underly	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
14	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
15	developmental	developmental	ADJ	JJ	Degree=Pos	_	_	_	_
16	control	control	NOUN	NN	Number=Sing	_	_	_	_
17	of	of	ADP	IN	_	_	_	_	_
18	globin	globin	ADJ	JJ	Degree=Pos	_	_	_	_
19	genes	gene	NOUN	NNS	Number=Plur	_	_	_	_
20	takes	take	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
21	place	place	NOUN	NN	Number=Sing	_	_	_	_
22	in	in	ADP	IN	_	_	_	_	_
23	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
24	gamma	gamma	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
25	-	-	PUNCT	,	_	_	_	_	_
26	and	and	CCONJ	CC	_	_	_	_	_
27	beta	beta	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
28	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
29	globin	globin	NOUN	NN	Number=Sing	_	_	_	_
30	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
31	promoters	promoter	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
32	,	,	PUNCT	,	_	_	_	_	_
33	and	and	CCONJ	CC	_	_	_	_	_
34	that	that	SCONJ	IN	_	_	_	_	_
35	GT	Gt	NOUN	NN	Number=Sing	_	_	_	_
36	motifs	motif	NOUN	NNS	Number=Plur	_	_	_	_
37	of	of	ADP	IN	_	_	_	_	_
38	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
39	beta	beta	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
40	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
41	globin	globin	NOUN	NN	Number=Sing	_	_	_	_
42	locus	locus	NOUN	NN	Number=Sing	_	_	_	_
43	LCR	Lcr	PROPN	NNP	Number=Sing	_	_	_	_
44	may	may	AUX	MD	VerbForm=Fin	_	_	_	_
45	play	play	VERB	VB	VerbForm=Inf	_	_	_	_
46	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
47	role	role	NOUN	NN	Number=Sing	_	_	_	_
48	in	in	ADP	IN	_	_	_	_	_
49	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
50	developmental	developmental	ADJ	JJ	Degree=Pos	_	_	_	_
51	regulation	regulation	NOUN	NN	Number=Sing	_	_	_	_
52	of	of	ADP	IN	_	_	_	_	_
53	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
54	beta	beta	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
55	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
56	globin	globin	NOUN	NN	Number=Sing	_	_	_	_
57	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
58	expression	expression	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
59	,	,	PUNCT	,	_	_	_	_	_
60	perhaps	perhaps	ADV	RB	_	_	_	_	_
61	by	by	SCONJ	IN	_	_	_	_	_
62	increasing	increase	VERB	VBG	VerbForm=Ger	_	_	_	_
63	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
64	probability	probability	NOUN	NN	Number=Sing	_	_	_	_
65	of	of	ADP	IN	_	_	_	_	_
66	interaction	interaction	NOUN	NN	Number=Sing	_	_	_	_
67	of	of	ADP	IN	_	_	_	_	_
68	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
69	LCR	LCR	PROPN	NNP	Number=Sing	_	_	_	_
70	holocomplex	holocomplex	NOUN	NN	Number=Sing	_	_	_	_
71	with	with	ADP	IN	_	_	_	_	_
72	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
73	fetal	fetal	ADJ	JJ	Degree=Pos	_	_	_	_
74	or	or	CCONJ	CC	_	_	_	_	_
75	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
76	adult	adult	NOUN	NN	Number=Sing	_	_	_	_
77	globin	globin	ADP	IN	_	_	_	_	_
78	gene	gene	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
79	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 1460
# text = Document 003002536 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	003002536	003002536	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 1461
# text = Differential regulation of 4E-BP1 and 4E-BP2, two repressors of translation initiation, during human myeloid cell differentiation.
1	Differential	differential	ADJ	JJ	Degree=Pos	_	_	_	_
2	regulation	regulation	NOUN	NN	Number=Sing	_	_	_	_
3	of	of	ADP	IN	_	_	_	_	_
4	4E	4E	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
5	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
6	BP1	BP1	PROPN	NNP	Number=Sing	_	_	_	_
7	and	and	CCONJ	CC	_	_	_	_	_
8	4E	4e	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
9	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
10	BP2	Bp2	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
11	,	,	PUNCT	,	_	_	_	_	_
12	two	two	NUM	CD	NumType=Card	_	_	_	_
13	repressors	repressor	NOUN	NNS	Number=Plur	_	_	_	_
14	of	of	ADP	IN	_	_	_	_	_
15	translation	translation	NOUN	NN	Number=Sing	_	_	_	_
16	initiation	initiation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
17	,	,	PUNCT	,	_	_	_	_	_
18	during	during	ADP	IN	_	_	_	_	_
19	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
20	myeloid	myeloid	NOUN	NN	Number=Sing	_	_	_	_
21	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
22	differentiation	differentiation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
23	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 1462
# text = Human myeloid differentiation is accompanied by a decrease in cell proliferation.
1	Human	human	ADJ	JJ	Degree=Pos	_	_	_	_
2	myeloid	myeloid	NOUN	NN	Number=Sing	_	_	_	_
3	differentiation	differentiation	NOUN	NN	Number=Sing	_	_	_	_
4	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
5	accompanied	accompany	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
6	by	by	ADP	IN	_	_	_	_	_
7	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
8	decrease	decrease	NOUN	NN	Number=Sing	_	_	_	_
9	in	in	ADP	IN	_	_	_	_	_
10	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
11	proliferation	proliferation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
12	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1463
# text = Because the translation rate is an important determinant of cell proliferation, we have investigated translation initiation during human myeloid cell differentiation using the HL-60 promyelocytic leukemia cell line and the U-937 monoblastic cell line.
1	Because	because	SCONJ	IN	_	_	_	_	_
2	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
3	translation	translation	NOUN	NN	Number=Sing	_	_	_	_
4	rate	rate	NOUN	NN	Number=Sing	_	_	_	_
5	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
6	an	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
7	important	important	ADJ	JJ	Degree=Pos	_	_	_	_
8	determinant	determinant	NOUN	NN	Number=Sing	_	_	_	_
9	of	of	ADP	IN	_	_	_	_	_
10	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
11	proliferation	proliferation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
12	,	,	PUNCT	,	_	_	_	_	_
13	we	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
14	have	have	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
15	investigated	investigate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
16	translation	translation	NOUN	NN	Number=Sing	_	_	_	_
17	initiation	initiation	NOUN	NN	Number=Sing	_	_	_	_
18	during	during	ADP	IN	_	_	_	_	_
19	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
20	myeloid	myeloid	NOUN	NN	Number=Sing	_	_	_	_
21	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
22	differentiation	differentiation	NOUN	NN	Number=Sing	_	_	_	_
23	using	use	VERB	VBG	VerbForm=Ger	_	_	_	_
24	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
25	HL	HL	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
26	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
27	60	60	NUM	CD	NumType=Card	_	_	_	_
28	promyelocytic	promyelocytic	ADJ	JJ	Degree=Pos	_	_	_	_
29	leukemia	leukemia	NOUN	NN	Number=Sing	_	_	_	_
30	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
31	line	line	NOUN	NN	Number=Sing	_	_	_	_
32	and	and	CCONJ	CC	_	_	_	_	_
33	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
34	U	U	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
35	-	-	SYM	SYM	_	_	_	_	SpaceAfter=No
36	937	937	NUM	CD	NumType=Card	_	_	_	_
37	monoblastic	monoblastic	ADJ	JJ	Degree=Pos	_	_	_	_
38	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
39	line	line	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
40	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1464
# text = A decrease in the translation rate is observed when the cells are induced to differentiate along the monocytic/macrophage pathway or along the granulocytic pathway.
1	A	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
2	decrease	decrease	NOUN	NN	Number=Sing	_	_	_	_
3	in	in	ADP	IN	_	_	_	_	_
4	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
5	translation	translation	NOUN	NN	Number=Sing	_	_	_	_
6	rate	rate	NOUN	NN	Number=Sing	_	_	_	_
7	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
8	observed	observe	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
9	when	when	ADV	WRB	PronType=Int	_	_	_	_
10	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
11	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
12	are	be	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
13	induced	induce	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
14	to	to	PART	TO	_	_	_	_	_
15	differentiate	differentiate	VERB	VB	VerbForm=Inf	_	_	_	_
16	along	along	ADP	IN	_	_	_	_	_
17	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
18	monocytic	monocytic	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
19	/	/	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
20	macrophage	macrophage	NOUN	NN	Number=Sing	_	_	_	_
21	pathway	pathway	NOUN	NN	Number=Sing	_	_	_	_
22	or	or	CCONJ	CC	_	_	_	_	_
23	along	along	ADP	IN	_	_	_	_	_
24	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
25	granulocytic	granulocytic	ADJ	JJ	Degree=Pos	_	_	_	_
26	pathway	pathway	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
27	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1465
# text = The inhibition in protein synthesis correlates with specific regulation of two repressors of translation initiation, 4E-BP1 and 4E-BP2.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	inhibition	inhibition	NOUN	NN	Number=Sing	_	_	_	_
3	in	in	ADP	IN	_	_	_	_	_
4	protein	protein	NOUN	NN	Number=Sing	_	_	_	_
5	synthesis	synthesis	NOUN	NN	Number=Sing	_	_	_	_
6	correlates	correlate	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
7	with	with	ADP	IN	_	_	_	_	_
8	specific	specific	ADJ	JJ	Degree=Pos	_	_	_	_
9	regulation	regulation	NOUN	NN	Number=Sing	_	_	_	_
10	of	of	ADP	IN	_	_	_	_	_
11	two	two	NUM	CD	NumType=Card	_	_	_	_
12	repressors	repressor	NOUN	NNS	Number=Plur	_	_	_	_
13	of	of	ADP	IN	_	_	_	_	_
14	translation	translation	NOUN	NN	Number=Sing	_	_	_	_
15	initiation	initiation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
16	,	,	PUNCT	,	_	_	_	_	_
17	4E	4e	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
18	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
19	BP1	Bp1	NOUN	NN	Number=Sing	_	_	_	_
20	and	and	CCONJ	CC	_	_	_	_	_
21	4E	4e	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
22	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
23	BP2	Bp2	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
24	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1466
# text = Induction of HL-60 and U-937 cell differentiation into monocytes/macrophages by IFN-gamma or PMA results in a dephosphorylation and consequent activation of 4E-BP1.
1	Induction	Induction	NOUN	NN	Number=Sing	_	_	_	_
2	of	of	ADP	IN	_	_	_	_	_
3	HL	HL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
4	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
5	60	60	NUM	CD	NumType=Card	_	_	_	_
6	and	and	CCONJ	CC	_	_	_	_	_
7	U	U	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
8	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
9	937	937	NUM	CD	NumType=Card	_	_	_	_
10	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
11	differentiation	differentiation	NOUN	NN	Number=Sing	_	_	_	_
12	into	into	ADP	IN	_	_	_	_	_
13	monocytes	monocyte	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
14	/	/	PUNCT	,	_	_	_	_	SpaceAfter=No
15	macrophages	macrophage	NOUN	NNS	Number=Plur	_	_	_	_
16	by	by	ADP	IN	_	_	_	_	_
17	IFN	IFN	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
18	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
19	gamma	gamma	PROPN	NNP	Number=Sing	_	_	_	_
20	or	or	CCONJ	CC	_	_	_	_	_
21	PMA	Pma	PROPN	NNP	Number=Sing	_	_	_	_
22	results	result	NOUN	NNS	Number=Plur	_	_	_	_
23	in	in	ADP	IN	_	_	_	_	_
24	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
25	dephosphorylation	dephosphorylation	NOUN	NN	Number=Sing	_	_	_	_
26	and	and	CCONJ	CC	_	_	_	_	_
27	consequent	consequent	ADJ	JJ	Degree=Pos	_	_	_	_
28	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
29	of	of	ADP	IN	_	_	_	_	_
30	4E	4E	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
31	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
32	BP1	BP1	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
33	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1467
# text = Dephosphorylation of 4E-BP1 was also observed when U-937 cells were induced to differentiate into monocytes/macrophages following treatment with retinoic acid or DMSO.
1	Dephosphorylation	Dephosphorylation	NOUN	NN	Number=Sing	_	_	_	_
2	of	of	ADP	IN	_	_	_	_	_
3	4E	4E	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
4	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
5	BP1	BP1	PROPN	NNP	Number=Sing	_	_	_	_
6	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
7	also	also	ADV	RB	_	_	_	_	_
8	observed	observe	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
9	when	when	ADV	WRB	PronType=Int	_	_	_	_
10	U	U	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
11	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
12	937	937	NUM	CD	NumType=Card	_	_	_	_
13	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
14	were	be	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
15	induced	induce	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
16	to	to	PART	TO	_	_	_	_	_
17	differentiate	differentiate	VERB	VB	VerbForm=Inf	_	_	_	_
18	into	into	ADP	IN	_	_	_	_	_
19	monocytes	monocyte	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
20	/	/	PUNCT	,	_	_	_	_	SpaceAfter=No
21	macrophages	macrophage	NOUN	NNS	Number=Plur	_	_	_	_
22	following	follow	VERB	VBG	VerbForm=Ger	_	_	_	_
23	treatment	treatment	NOUN	NN	Number=Sing	_	_	_	_
24	with	with	ADP	IN	_	_	_	_	_
25	retinoic	retinoic	ADJ	JJ	Degree=Pos	_	_	_	_
26	acid	acid	NOUN	NN	Number=Sing	_	_	_	_
27	or	or	CCONJ	CC	_	_	_	_	_
28	DMSO	DMSO	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
29	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1468
# text = In contrast, treatment of HL-60 cells with retinoic acid or DMSO, which results in a granulocytic differentiation of these cells, decreases 4E-BP1 amount without affecting its phosphorylation and strongly increases 4E-BP2 amount.
1	In	in	ADP	IN	_	_	_	_	_
2	contrast	contrast	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
3	,	,	PUNCT	,	_	_	_	_	_
4	treatment	treatment	NOUN	NN	Number=Sing	_	_	_	_
5	of	of	ADP	IN	_	_	_	_	_
6	HL	HL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
7	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
8	60	60	NUM	CD	NumType=Card	_	_	_	_
9	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
10	with	with	ADP	IN	_	_	_	_	_
11	retinoic	retinoic	ADJ	JJ	Degree=Pos	_	_	_	_
12	acid	acid	NOUN	NN	Number=Sing	_	_	_	_
13	or	or	CCONJ	CC	_	_	_	_	_
14	DMSO	Dmso	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
15	,	,	PUNCT	,	_	_	_	_	_
16	which	which	DET	WDT	PronType=Int	_	_	_	_
17	results	result	NOUN	NNS	Number=Plur	_	_	_	_
18	in	in	ADP	IN	_	_	_	_	_
19	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
20	granulocytic	granulocytic	ADJ	JJ	Degree=Pos	_	_	_	_
21	differentiation	differentiation	NOUN	NN	Number=Sing	_	_	_	_
22	of	of	ADP	IN	_	_	_	_	_
23	these	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
24	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
25	,	,	PUNCT	,	_	_	_	_	_
26	decreases	decrease	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
27	4E	4e	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
28	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
29	BP1	Bp1	PROPN	NNP	Number=Sing	_	_	_	_
30	amount	amount	NOUN	NN	Number=Sing	_	_	_	_
31	without	without	SCONJ	IN	_	_	_	_	_
32	affecting	affect	VERB	VBG	VerbForm=Ger	_	_	_	_
33	its	its	PRON	PRP$	Gender=Neut|Number=Sing|Person=3|Poss=Yes|PronType=Prs	_	_	_	_
34	phosphorylation	phosphorylation	NOUN	NN	Number=Sing	_	_	_	_
35	and	and	CCONJ	CC	_	_	_	_	_
36	strongly	strongly	ADV	RB	_	_	_	_	_
37	increases	increase	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
38	4E	4e	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
39	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
40	BP2	Bp2	NUM	CD	NumType=Card	_	_	_	_
41	amount	amount	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
42	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1469
# text = Taken together, these data provide evidence for differential regulation of the translational machinery during human myeloid differentiation, specific to the monocytic/macrophage pathway or to the granulocytic pathway.
1	Taken	take	PROPN	NNP	Number=Sing	_	_	_	_
2	together	together	ADV	RB	_	_	_	_	SpaceAfter=No
3	,	,	PUNCT	,	_	_	_	_	_
4	these	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
5	data	data	NOUN	NN	Number=Sing	_	_	_	_
6	provide	provide	VERB	VB	VerbForm=Inf	_	_	_	_
7	evidence	evidence	NOUN	NN	Number=Sing	_	_	_	_
8	for	for	ADP	IN	_	_	_	_	_
9	differential	differential	ADJ	JJ	Degree=Pos	_	_	_	_
10	regulation	regulation	NOUN	NN	Number=Sing	_	_	_	_
11	of	of	ADP	IN	_	_	_	_	_
12	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
13	translational	translational	ADJ	JJ	Degree=Pos	_	_	_	_
14	machinery	machinery	NOUN	NN	Number=Sing	_	_	_	_
15	during	during	ADP	IN	_	_	_	_	_
16	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
17	myeloid	myeloid	NOUN	NN	Number=Sing	_	_	_	_
18	differentiation	differentiation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
19	,	,	PUNCT	,	_	_	_	_	_
20	specific	specific	ADJ	JJ	Degree=Pos	_	_	_	_
21	to	to	ADP	IN	_	_	_	_	_
22	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
23	monocytic	monocytic	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
24	/	/	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
25	macrophage	macrophage	NOUN	NN	Number=Sing	_	_	_	_
26	pathway	pathway	NOUN	NN	Number=Sing	_	_	_	_
27	or	or	CCONJ	CC	_	_	_	_	_
28	to	to	ADP	IN	_	_	_	_	_
29	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
30	granulocytic	granulocytic	ADJ	JJ	Degree=Pos	_	_	_	_
31	pathway	pathway	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
32	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 1470
# text = Document 003002537 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	003002537	003002537	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 1471
# text = Regulatory effects of interleukin-11 during acute lung inflammatory injury.
1	Regulatory	Regulatory	ADJ	JJ	Degree=Pos	_	_	_	_
2	effects	effect	NOUN	NNS	Number=Plur	_	_	_	_
3	of	of	ADP	IN	_	_	_	_	_
4	interleukin	interleukin	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
5	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
6	11	11	NUM	CD	NumType=Card	_	_	_	_
7	during	during	ADP	IN	_	_	_	_	_
8	acute	acute	ADJ	JJ	Degree=Pos	_	_	_	_
9	lung	lung	NOUN	NN	Number=Sing	_	_	_	_
10	inflammatory	inflammatory	ADJ	JJ	Degree=Pos	_	_	_	_
11	injury	injury	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
12	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 1472
# text = The role of interleukin-11 (IL-11) was evaluated in the IgG immune complex model of acute lung injury in rats.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	role	role	NOUN	NN	Number=Sing	_	_	_	_
3	of	of	ADP	IN	_	_	_	_	_
4	interleukin	interleukin	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
5	-11	-11	NUM	CD	NumType=Card	_	_	_	_
6	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
7	IL	Il	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
8	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
9	11	11	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
10	)	)	PUNCT	-RRB-	_	_	_	_	_
11	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
12	evaluated	evaluate	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
13	in	in	ADP	IN	_	_	_	_	_
14	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
15	IgG	IgG	PROPN	NNP	Number=Sing	_	_	_	_
16	immune	immune	ADJ	JJ	Degree=Pos	_	_	_	_
17	complex	complex	ADJ	JJ	Degree=Pos	_	_	_	_
18	model	model	NOUN	NN	Number=Sing	_	_	_	_
19	of	of	ADP	IN	_	_	_	_	_
20	acute	acute	ADJ	JJ	Degree=Pos	_	_	_	_
21	lung	lung	NOUN	NN	Number=Sing	_	_	_	_
22	injury	injury	NOUN	NN	Number=Sing	_	_	_	_
23	in	in	ADP	IN	_	_	_	_	_
24	rats	rat	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
25	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1473
# text = IL-11 mRNA and protein were both up-regulated during the course of this inflammatory response.
1	IL	Il	INTJ	UH	_	_	_	_	SpaceAfter=No
2	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
3	11	11	NUM	CD	NumType=Card	_	_	_	_
4	mRNA	mRNa	NOUN	NN	Number=Sing	_	_	_	_
5	and	and	CCONJ	CC	_	_	_	_	_
6	protein	protein	NOUN	NN	Number=Sing	_	_	_	_
7	were	be	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
8	both	both	ADV	RB	_	_	_	_	_
9	up	up	ADV	RB	_	_	_	_	SpaceAfter=No
10	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
11	regulated	regulate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
12	during	during	ADP	IN	_	_	_	_	_
13	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
14	course	course	NOUN	NN	Number=Sing	_	_	_	_
15	of	of	ADP	IN	_	_	_	_	_
16	this	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
17	inflammatory	inflammatory	ADJ	JJ	Degree=Pos	_	_	_	_
18	response	response	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
19	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1474
# text = Exogenously administered IL-11 substantially reduced, in a dose-dependent manner, the intrapulmonary accumulation of neutrophils and the lung vascular leak of albumin.
1	Exogenously	Exogenously	ADV	RB	_	_	_	_	_
2	administered	administer	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
3	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
4	-	-	SYM	SYM	_	_	_	_	SpaceAfter=No
5	11	11	NUM	CD	NumType=Card	_	_	_	_
6	substantially	substantially	ADV	RB	_	_	_	_	_
7	reduced	reduce	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	SpaceAfter=No
8	,	,	PUNCT	,	_	_	_	_	_
9	in	in	ADP	IN	_	_	_	_	_
10	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
11	dose	dose	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
12	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
13	dependent	dependent	ADJ	JJ	Degree=Pos	_	_	_	_
14	manner	manner	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
15	,	,	PUNCT	,	_	_	_	_	_
16	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
17	intrapulmonary	intrapulmonary	ADJ	JJ	Degree=Pos	_	_	_	_
18	accumulation	accumulation	NOUN	NN	Number=Sing	_	_	_	_
19	of	of	ADP	IN	_	_	_	_	_
20	neutrophils	neutrophil	NOUN	NNS	Number=Plur	_	_	_	_
21	and	and	CCONJ	CC	_	_	_	_	_
22	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
23	lung	lung	ADJ	JJ	Degree=Pos	_	_	_	_
24	vascular	vascular	ADJ	JJ	Degree=Pos	_	_	_	_
25	leak	leak	NOUN	NN	Number=Sing	_	_	_	_
26	of	of	ADP	IN	_	_	_	_	_
27	albumin	albumin	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
28	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1475
# text = These in vivo anti-inflammatory effects of IL-11 were associated with reduced NF-kappaB activation in lung, reduced levels of tumor necrosis factor alpha (TNF-alpha) in bronchoalveolar lavage (BAL) fluids, and diminished up-regulation of lung vascular ICAM-1.
1	These	these	PRON	DT	Number=Plur|PronType=Dem	_	_	_	_
2	in	in	ADP	IN	_	_	_	_	_
3	vivo	vivo	ADJ	JJ	Degree=Pos	_	_	_	_
4	anti-inflammatory	anti-inflammatory	ADJ	JJ	Degree=Pos	_	_	_	_
5	effects	effect	NOUN	NNS	Number=Plur	_	_	_	_
6	of	of	ADP	IN	_	_	_	_	_
7	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
8	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
9	11	11	NUM	CD	NumType=Card	_	_	_	_
10	were	be	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
11	associated	associate	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
12	with	with	ADP	IN	_	_	_	_	_
13	reduced	reduce	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
14	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
15	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
16	kappaB	kappaB	PROPN	NNP	Number=Sing	_	_	_	_
17	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
18	in	in	ADP	IN	_	_	_	_	_
19	lung	lung	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
20	,	,	PUNCT	,	_	_	_	_	_
21	reduced	reduce	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
22	levels	level	NOUN	NNS	Number=Plur	_	_	_	_
23	of	of	ADP	IN	_	_	_	_	_
24	tumor	tumor	NOUN	NN	Number=Sing	_	_	_	_
25	necrosis	necrosis	NOUN	NN	Number=Sing	_	_	_	_
26	factor	factor	NOUN	NN	Number=Sing	_	_	_	_
27	alpha	alpha	NOUN	NN	Number=Sing	_	_	_	_
28	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
29	TNF	Tnf	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
30	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
31	alpha	alpha	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
32	)	)	PUNCT	-RRB-	_	_	_	_	_
33	in	in	ADP	IN	_	_	_	_	_
34	bronchoalveolar	bronchoalveolar	ADJ	JJ	Degree=Pos	_	_	_	_
35	lavage	lavage	NOUN	NN	Number=Sing	_	_	_	_
36	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
37	BAL	Bal	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
38	)	)	PUNCT	-RRB-	_	_	_	_	_
39	fluids	fluid	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
40	,	,	PUNCT	,	_	_	_	_	_
41	and	and	CCONJ	CC	_	_	_	_	_
42	diminished	diminish	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
43	up	up	ADP	RP	_	_	_	_	SpaceAfter=No
44	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
45	regulation	regulation	NOUN	NN	Number=Sing	_	_	_	_
46	of	of	ADP	IN	_	_	_	_	_
47	lung	lung	ADJ	JJ	Degree=Pos	_	_	_	_
48	vascular	vascular	ADJ	JJ	Degree=Pos	_	_	_	_
49	ICAM	ICAm	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
50	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
51	1	1	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
52	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1476
# text = It is interesting that IL-11 did not affect BAL fluid content of the CXC chemokines, macrophage inflammatory protein-2 (MIP-2) and cytokine-inducible neutrophil chemoattractant (CINC); the presence of IL-11 did not affect these chemokines.
1	It	it	PRON	PRP	Case=Nom|Gender=Neut|Number=Sing|Person=3|PronType=Prs	_	_	_	_
2	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
3	interesting	interesting	ADJ	JJ	Degree=Pos	_	_	_	_
4	that	that	SCONJ	IN	_	_	_	_	_
5	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
6	-	-	SYM	SYM	_	_	_	_	SpaceAfter=No
7	11	11	NUM	CD	NumType=Card	_	_	_	_
8	did	do	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
9	not	not	PART	RB	_	_	_	_	_
10	affect	affect	VERB	VB	VerbForm=Inf	_	_	_	_
11	BAL	Bal	ADJ	JJ	Degree=Pos	_	_	_	_
12	fluid	fluid	NOUN	NN	Number=Sing	_	_	_	_
13	content	content	NOUN	NN	Number=Sing	_	_	_	_
14	of	of	ADP	IN	_	_	_	_	_
15	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
16	CXC	CXC	NOUN	NN	Number=Sing	_	_	_	_
17	chemokines	chemokine	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
18	,	,	PUNCT	,	_	_	_	_	_
19	macrophage	macrophage	ADJ	JJ	Degree=Pos	_	_	_	_
20	inflammatory	inflammatory	ADJ	JJ	Degree=Pos	_	_	_	_
21	protein	protein	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
22	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
23	2	2	NUM	CD	NumType=Card	_	_	_	_
24	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
25	MIP	Mip	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
26	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
27	2	2	X	LS	_	_	_	_	SpaceAfter=No
28	)	)	PUNCT	-RRB-	_	_	_	_	_
29	and	and	CCONJ	CC	_	_	_	_	_
30	cytokine	cytokine	VERB	VB	VerbForm=Inf	_	_	_	SpaceAfter=No
31	-inducible	-inducible	ADJ	JJ	Degree=Pos	_	_	_	_
32	neutrophil	neutrophil	NOUN	NN	Number=Sing	_	_	_	_
33	chemoattractant	chemoattractant	NOUN	NN	Number=Sing	_	_	_	_
34	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
35	CINC	CINC	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
36	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
37	;	;	PUNCT	,	_	_	_	_	_
38	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
39	presence	presence	NOUN	NN	Number=Sing	_	_	_	_
40	of	of	ADP	IN	_	_	_	_	_
41	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
42	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
43	11	11	NUM	CD	NumType=Card	_	_	_	_
44	did	do	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
45	not	not	PART	RB	_	_	_	_	_
46	affect	affect	VERB	VB	VerbForm=Inf	_	_	_	_
47	these	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
48	chemokines	chemokine	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
49	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1477
# text = However, BAL content of C5a was reduced by IL-11.
1	However	however	ADV	RB	_	_	_	_	SpaceAfter=No
2	,	,	PUNCT	,	_	_	_	_	_
3	BAL	Bal	ADJ	NNP	Number=Sing	_	_	_	_
4	content	content	NOUN	NN	Number=Sing	_	_	_	_
5	of	of	ADP	IN	_	_	_	_	_
6	C5	C5	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
7	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
8	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
9	reduced	reduce	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
10	by	by	ADP	IN	_	_	_	_	_
11	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
12	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
13	11	11	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
14	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1478
# text = These data indicate that IL-11 is a regulatory cytokine in the lung and that, like other members of this family, its anti-inflammatory properties appear to be linked to its suppression of NF-kappaB activation, diminished production of TNF-alpha, and reduced up-regulation of lung vascular ICAM-1.
1	These	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
2	data	data	NOUN	NN	Number=Sing	_	_	_	_
3	indicate	indicate	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
4	that	that	SCONJ	IN	_	_	_	_	_
5	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
6	-	-	SYM	SYM	_	_	_	_	SpaceAfter=No
7	11	11	NUM	CD	NumType=Card	_	_	_	_
8	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
9	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
10	regulatory	regulatory	ADJ	JJ	Degree=Pos	_	_	_	_
11	cytokine	cytokine	NOUN	NN	Number=Sing	_	_	_	_
12	in	in	ADP	IN	_	_	_	_	_
13	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
14	lung	lung	NOUN	NN	Number=Sing	_	_	_	_
15	and	and	CCONJ	CC	_	_	_	_	_
16	that	that	PRON	DT	Number=Sing|PronType=Dem	_	_	_	SpaceAfter=No
17	,	,	PUNCT	,	_	_	_	_	_
18	like	like	ADP	IN	_	_	_	_	_
19	other	other	ADJ	JJ	Degree=Pos	_	_	_	_
20	members	member	NOUN	NNS	Number=Plur	_	_	_	_
21	of	of	ADP	IN	_	_	_	_	_
22	this	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
23	family	family	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
24	,	,	PUNCT	,	_	_	_	_	_
25	its	its	PRON	PRP$	Gender=Neut|Number=Sing|Person=3|Poss=Yes|PronType=Prs	_	_	_	_
26	anti-inflammatory	anti-inflammatory	ADJ	JJ	Degree=Pos	_	_	_	_
27	properties	property	NOUN	NNS	Number=Plur	_	_	_	_
28	appear	appear	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
29	to	to	PART	TO	_	_	_	_	_
30	be	be	AUX	VB	VerbForm=Inf	_	_	_	_
31	linked	link	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
32	to	to	ADP	IN	_	_	_	_	_
33	its	its	PRON	PRP$	Gender=Neut|Number=Sing|Person=3|Poss=Yes|PronType=Prs	_	_	_	_
34	suppression	suppression	NOUN	NN	Number=Sing	_	_	_	_
35	of	of	ADP	IN	_	_	_	_	_
36	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
37	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
38	kappaB	kappaB	PROPN	NNP	Number=Sing	_	_	_	_
39	activation	activation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
40	,	,	PUNCT	,	_	_	_	_	_
41	diminished	diminish	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
42	production	production	NOUN	NN	Number=Sing	_	_	_	_
43	of	of	ADP	IN	_	_	_	_	_
44	TNF	TNF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
45	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
46	alpha	alpha	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
47	,	,	PUNCT	,	_	_	_	_	_
48	and	and	CCONJ	CC	_	_	_	_	_
49	reduced	reduce	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
50	up	up	ADP	RP	_	_	_	_	SpaceAfter=No
51	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
52	regulation	regulation	NOUN	NN	Number=Sing	_	_	_	_
53	of	of	ADP	IN	_	_	_	_	_
54	lung	lung	ADJ	JJ	Degree=Pos	_	_	_	_
55	vascular	vascular	ADJ	JJ	Degree=Pos	_	_	_	_
56	ICAM	ICAm	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
57	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
58	1	1	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
59	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 1479
# text = Document 003002
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	003002	003002	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No

# sent_id = 1480
# text = 544 ends.
1	544	544	NUM	CD	NumType=Card	_	_	_	_
2	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
3	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 1481
# text = v-erbA overexpression is required to extinguish c-erbA function in erythroid cell differentiation and regulation of the erbA target gene CAII.
1	v-	v-	SYM	NFP	_	_	_	_	SpaceAfter=No
2	erbA	erbA	NOUN	NN	Number=Sing	_	_	_	_
3	overexpression	overexpression	NOUN	NN	Number=Sing	_	_	_	_
4	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
5	required	require	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
6	to	to	PART	TO	_	_	_	_	_
7	extinguish	extinguish	VERB	VB	VerbForm=Inf	_	_	_	_
8	c-	c-	PUNCT	,	_	_	_	_	SpaceAfter=No
9	erbA	erba	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
10	function	function	NOUN	NN	Number=Sing	_	_	_	_
11	in	in	ADP	IN	_	_	_	_	_
12	erythroid	erythroid	ADJ	JJ	Degree=Pos	_	_	_	_
13	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
14	differentiation	differentiation	NOUN	NN	Number=Sing	_	_	_	_
15	and	and	CCONJ	CC	_	_	_	_	_
16	regulation	regulation	NOUN	NN	Number=Sing	_	_	_	_
17	of	of	ADP	IN	_	_	_	_	_
18	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
19	erbA	erbA	PROPN	NNP	Number=Sing	_	_	_	_
20	target	target	NOUN	NN	Number=Sing	_	_	_	_
21	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
22	CAII	caii	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
23	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 1482
# text = The v-erbA oncoprotein represents a retrovirus-transduced oncogenic version of the thyroid hormone (T3/T4) receptor c-erbA (type alpha).
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	v-	v-	SYM	NFP	_	_	_	_	SpaceAfter=No
3	erbA	erbA	PROPN	NNP	Number=Sing	_	_	_	_
4	oncoprotein	oncoprotein	ADV	RB	_	_	_	_	_
5	represents	represent	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
6	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
7	retrovirus	retrovirus	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
8	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
9	transduced	transduce	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
10	oncogenic	oncogenic	ADJ	JJ	Degree=Pos	_	_	_	_
11	version	version	NOUN	NN	Number=Sing	_	_	_	_
12	of	of	ADP	IN	_	_	_	_	_
13	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
14	thyroid	thyroid	NOUN	NN	Number=Sing	_	_	_	_
15	hormone	hormone	NOUN	NN	Number=Sing	_	_	_	_
16	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
17	T3/	T3/	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
18	T4	T4	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
19	)	)	PUNCT	-RRB-	_	_	_	_	_
20	receptor	receptor	NOUN	NN	Number=Sing	_	_	_	_
21	c-	c-	PUNCT	:	_	_	_	_	SpaceAfter=No
22	erbA	erbA	PROPN	NNP	Number=Sing	_	_	_	_
23	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
24	type	type	NOUN	NN	Number=Sing	_	_	_	_
25	alpha	alpha	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
26	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
27	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1483
# text = It contributes to virus-induced erythroleukemia by efficiently arresting differentiation of red cell progenitors and by suppressing transcription of erythrocyte-specific genes.
1	It	it	PRON	PRP	Case=Nom|Gender=Neut|Number=Sing|Person=3|PronType=Prs	_	_	_	_
2	contributes	contribute	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
3	to	to	PART	TO	_	_	_	_	_
4	virus	virus	VERB	VB	VerbForm=Inf	_	_	_	SpaceAfter=No
5	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
6	induced	induce	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
7	erythroleukemia	erythroleukemia	NOUN	NN	Number=Sing	_	_	_	_
8	by	by	SCONJ	IN	_	_	_	_	_
9	efficiently	efficiently	ADV	RB	_	_	_	_	_
10	arresting	arreste	VERB	VBG	VerbForm=Ger	_	_	_	_
11	differentiation	differentiation	NOUN	NN	Number=Sing	_	_	_	_
12	of	of	ADP	IN	_	_	_	_	_
13	red	red	ADJ	JJ	Degree=Pos	_	_	_	_
14	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
15	progenitors	progenitor	NOUN	NNS	Number=Plur	_	_	_	_
16	and	and	CCONJ	CC	_	_	_	_	_
17	by	by	SCONJ	IN	_	_	_	_	_
18	suppressing	suppresse	VERB	VBG	VerbForm=Ger	_	_	_	_
19	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
20	of	of	ADP	IN	_	_	_	_	_
21	erythrocyte-specific	erythrocyte-specific	ADJ	JJ	Degree=Pos	_	_	_	_
22	genes	gene	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
23	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1484
# text = Here, we show that v-erbA and c-erbA bind directly to sequences within the promoter of the erythrocyte-specific carbonic anhydrase II (CAII), a gene whose transcription is efficiently suppressed by v-erbA.
1	Here	here	ADV	RB	PronType=Dem	_	_	_	SpaceAfter=No
2	,	,	PUNCT	,	_	_	_	_	_
3	we	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
4	show	show	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
5	that	that	SCONJ	IN	_	_	_	_	_
6	v-	v-	SYM	NFP	_	_	_	_	SpaceAfter=No
7	erbA	erbA	PROPN	NNP	Number=Sing	_	_	_	_
8	and	and	CCONJ	CC	_	_	_	_	_
9	c-	c-	SYM	NFP	_	_	_	_	SpaceAfter=No
10	erbA	erbA	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
11	bind	bind	NOUN	NN	Number=Sing	_	_	_	_
12	directly	directly	ADV	RB	_	_	_	_	_
13	to	to	ADP	IN	_	_	_	_	_
14	sequences	sequence	NOUN	NNS	Number=Plur	_	_	_	_
15	within	within	ADP	IN	_	_	_	_	_
16	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
17	promoter	promoter	NOUN	NN	Number=Sing	_	_	_	_
18	of	of	ADP	IN	_	_	_	_	_
19	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
20	erythrocyte-	erythrocyte-	SYM	SYM	_	_	_	_	SpaceAfter=No
21	specific	specific	ADJ	JJ	Degree=Pos	_	_	_	_
22	carbonic	carbonic	NOUN	NN	Number=Sing	_	_	_	_
23	anhydrase	anhydrase	NOUN	NN	Number=Sing	_	_	_	_
24	II	ii	NUM	CD	NumType=Card	_	_	_	_
25	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
26	CAII	Caii	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
27	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
28	,	,	PUNCT	,	_	_	_	_	_
29	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
30	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
31	whose	whose	PRON	WP$	Poss=Yes|PronType=Int	_	_	_	_
32	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
33	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
34	efficiently	efficiently	ADV	RB	_	_	_	_	_
35	suppressed	suppress	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
36	by	by	ADP	IN	_	_	_	_	_
37	v-	v-	SYM	NFP	_	_	_	_	SpaceAfter=No
38	erbA	erbA	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
39	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1485
# text = This erbA-binding site confers thyroid hormone responsiveness to a heterologous promoter in transient expression experiments and is a target for efficient down-regulation of CAII transcription by the v-erbA oncoprotein.
1	This	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
2	erbA-	erbA-	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
3	binding	bind	VERB	VBG	VerbForm=Ger	_	_	_	_
4	site	site	NOUN	NN	Number=Sing	_	_	_	_
5	confers	confer	NOUN	NNS	Number=Plur	_	_	_	_
6	thyroid	thyroid	NOUN	NN	Number=Sing	_	_	_	_
7	hormone	hormone	NOUN	NN	Number=Sing	_	_	_	_
8	responsiveness	responsiveness	NOUN	NN	Number=Sing	_	_	_	_
9	to	to	ADP	IN	_	_	_	_	_
10	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
11	heterologous	heterologous	ADJ	JJ	Degree=Pos	_	_	_	_
12	promoter	promoter	NOUN	NN	Number=Sing	_	_	_	_
13	in	in	ADP	IN	_	_	_	_	_
14	transient	transient	ADJ	JJ	Degree=Pos	_	_	_	_
15	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
16	experiments	experiment	NOUN	NNS	Number=Plur	_	_	_	_
17	and	and	CCONJ	CC	_	_	_	_	_
18	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
19	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
20	target	target	NOUN	NN	Number=Sing	_	_	_	_
21	for	for	ADP	IN	_	_	_	_	_
22	efficient	efficient	ADJ	JJ	Degree=Pos	_	_	_	_
23	down	down	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
24	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
25	regulation	regulation	NOUN	NN	Number=Sing	_	_	_	_
26	of	of	ADP	IN	_	_	_	_	_
27	CAII	Caii	PROPN	NNP	Number=Sing	_	_	_	_
28	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
29	by	by	ADP	IN	_	_	_	_	_
30	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
31	v-	v-	SYM	NFP	_	_	_	_	SpaceAfter=No
32	erbA	erbA	PROPN	NNP	Number=Sing	_	_	_	_
33	oncoprotein	oncoprotein	ADV	RB	_	_	_	_	SpaceAfter=No
34	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1486
# text = In stably transformed erythroblasts coexpressing the v-erbA oncoprotein and the c-erbA/T3 receptor at an approximately equimolar ratio, c-erbA activity is dominant over v-erbA.
1	In	in	ADP	IN	_	_	_	_	_
2	stably	stably	ADV	RB	_	_	_	_	_
3	transformed	transform	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
4	erythroblasts	erythroblast	NOUN	NNS	Number=Plur	_	_	_	_
5	coexpressing	coexpresse	VERB	VBG	VerbForm=Ger	_	_	_	_
6	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
7	v-	v-	SYM	NFP	_	_	_	_	SpaceAfter=No
8	erbA	erbA	PROPN	NNP	Number=Sing	_	_	_	_
9	oncoprotein	oncoprotein	PROPN	NNP	Number=Sing	_	_	_	_
10	and	and	CCONJ	CC	_	_	_	_	_
11	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
12	c-	c-	SYM	SYM	_	_	_	_	SpaceAfter=No
13	erbA/T3	erbA/T3	NUM	CD	NumType=Card	_	_	_	_
14	receptor	receptor	NOUN	NN	Number=Sing	_	_	_	_
15	at	at	ADP	IN	_	_	_	_	_
16	an	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
17	approximately	approximately	ADV	RB	_	_	_	_	_
18	equimolar	equimolar	ADJ	JJ	Degree=Pos	_	_	_	_
19	ratio	ratio	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
20	,	,	PUNCT	,	_	_	_	_	_
21	c-	c-	SYM	NFP	_	_	_	_	SpaceAfter=No
22	erbA	erbA	ADJ	JJ	Degree=Pos	_	_	_	_
23	activity	activity	NOUN	NN	Number=Sing	_	_	_	_
24	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
25	dominant	dominant	ADJ	JJ	Degree=Pos	_	_	_	_
26	over	over	ADP	IN	_	_	_	_	_
27	v-	v-	SYM	NFP	_	_	_	_	SpaceAfter=No
28	erbA.	erbA.	PROPN	NNP	Number=Sing	_	_	_	_

# sent_id = 1487
# text = T3 efficiently induced erythroid differentiation in these cells, thus overcoming the v-erbA-mediated differentiation arrest.
1	T3	T3	NUM	CD	NumType=Card	_	_	_	_
2	efficiently	efficiently	ADV	RB	_	_	_	_	_
3	induced	induce	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
4	erythroid	erythroid	ADJ	JJ	Degree=Pos	_	_	_	_
5	differentiation	differentiation	NOUN	NN	Number=Sing	_	_	_	_
6	in	in	ADP	IN	_	_	_	_	_
7	these	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
8	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
9	,	,	PUNCT	,	_	_	_	_	_
10	thus	thus	ADV	RB	_	_	_	_	_
11	overcoming	overcom	VERB	VBG	VerbForm=Ger	_	_	_	_
12	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
13	v-	v-	SYM	NFP	_	_	_	_	SpaceAfter=No
14	erbA	erbA	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
15	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
16	mediated	mediate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
17	differentiation	differentiation	NOUN	NN	Number=Sing	_	_	_	_
18	arrest	arrest	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
19	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1488
# text = Likewise, T3 activated CAII transcription as well as transient expression of a T3-responsive reporter gene containing the CAII-specific erbA-binding site.
1	Likewise	likewise	ADV	RB	_	_	_	_	SpaceAfter=No
2	,	,	PUNCT	,	_	_	_	_	_
3	T3	T3	NUM	CD	NumType=Card	_	_	_	_
4	activated	activate	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
5	CAII	Caii	NUM	CD	NumType=Card	_	_	_	_
6	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
7	as	as	ADV	RB	_	_	_	_	_
8	well	well	ADV	RB	Degree=Pos	_	_	_	_
9	as	as	ADP	IN	_	_	_	_	_
10	transient	transient	ADJ	JJ	Degree=Pos	_	_	_	_
11	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
12	of	of	ADP	IN	_	_	_	_	_
13	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
14	T3	T3	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
15	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
16	responsive	responsive	ADJ	JJ	Degree=Pos	_	_	_	_
17	reporter	reporter	NOUN	NN	Number=Sing	_	_	_	_
18	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
19	containing	contain	VERB	VBG	VerbForm=Ger	_	_	_	_
20	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
21	CAII	CAII	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
22	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
23	specific	specific	ADJ	JJ	Degree=Pos	_	_	_	_
24	erbA-	erba-	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
25	binding	bind	VERB	VBG	VerbForm=Ger	_	_	_	_
26	site	site	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
27	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1489
# text = The c-erbA-dependent activation of this CAII reporter construct could only be suppressed by very high amounts of v-erbA.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	c-	c-	SYM	NFP	_	_	_	_	SpaceAfter=No
3	erbA-dependent	erbA-dependent	ADJ	JJ	Degree=Pos	_	_	_	_
4	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
5	of	of	ADP	IN	_	_	_	_	_
6	this	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
7	CAII	CAII	ADJ	JJ	Degree=Pos	_	_	_	_
8	reporter	reporter	NOUN	NN	Number=Sing	_	_	_	_
9	construct	construct	NOUN	NN	Number=Sing	_	_	_	_
10	could	could	AUX	MD	VerbForm=Fin	_	_	_	_
11	only	only	ADV	RB	_	_	_	_	_
12	be	be	AUX	VB	VerbForm=Inf	_	_	_	_
13	suppressed	suppress	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
14	by	by	ADP	IN	_	_	_	_	_
15	very	very	ADV	RB	_	_	_	_	_
16	high	high	ADJ	JJ	Degree=Pos	_	_	_	_
17	amounts	amount	NOUN	NNS	Number=Plur	_	_	_	_
18	of	of	ADP	IN	_	_	_	_	_
19	v-	v-	SYM	NFP	_	_	_	_	SpaceAfter=No
20	erbA	erbA	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
21	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1490
# text = Our results suggest that overexpression of v-erbA is required for its function as an oncoprotein.
1	Our	we	PRON	PRP$	Number=Plur|Person=1|Poss=Yes|PronType=Prs	_	_	_	_
2	results	result	NOUN	NNS	Number=Plur	_	_	_	_
3	suggest	suggest	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
4	that	that	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
5	overexpression	overexpression	NOUN	NN	Number=Sing	_	_	_	_
6	of	of	ADP	IN	_	_	_	_	_
7	v-	v-	PUNCT	,	_	_	_	_	SpaceAfter=No
8	erbA	erbA	PROPN	NNP	Number=Sing	_	_	_	_
9	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
10	required	require	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
11	for	for	ADP	IN	_	_	_	_	_
12	its	its	PRON	PRP$	Gender=Neut|Number=Sing|Person=3|Poss=Yes|PronType=Prs	_	_	_	_
13	function	function	NOUN	NN	Number=Sing	_	_	_	_
14	as	as	ADP	IN	_	_	_	_	_
15	an	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
16	oncoprotein	oncoprotein	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
17	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 1491
# text = Document 003002548 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	003002548	003002548	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 1492
# text = Differential induction of the NF-AT complex during restimulation and the induction of T-cell anergy.
1	Differential	differential	ADJ	JJ	Degree=Pos	_	_	_	_
2	induction	induction	NOUN	NN	Number=Sing	_	_	_	_
3	of	of	ADP	IN	_	_	_	_	_
4	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
5	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
6	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
7	AT	AT	ADJ	JJ	Degree=Pos	_	_	_	_
8	complex	complex	NOUN	NN	Number=Sing	_	_	_	_
9	during	during	ADP	IN	_	_	_	_	_
10	restimulation	restimulation	NOUN	NN	Number=Sing	_	_	_	_
11	and	and	CCONJ	CC	_	_	_	_	_
12	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
13	induction	induction	NOUN	NN	Number=Sing	_	_	_	_
14	of	of	ADP	IN	_	_	_	_	_
15	T-	t-	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
16	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
17	anergy	anergy	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
18	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 1493
# text = Stimulation of human CD4+ T-cell clones through the T-cell receptor (TcR) by high doses of specific peptide results in the induction of a long-lived state of nonresponsiveness that has been called anergy.
1	Stimulation	Stimulation	NOUN	NN	Number=Sing	_	_	_	_
2	of	of	ADP	IN	_	_	_	_	_
3	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
4	CD4	CD4	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
5	+	+	SYM	SYM	_	_	_	_	_
6	T-	T-	SYM	NFP	_	_	_	_	SpaceAfter=No
7	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
8	clones	clone	NOUN	NNS	Number=Plur	_	_	_	_
9	through	through	ADP	IN	_	_	_	_	_
10	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
11	T-	t-	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
12	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
13	receptor	receptor	NOUN	NN	Number=Sing	_	_	_	_
14	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
15	TcR	TcR	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
16	)	)	PUNCT	-RRB-	_	_	_	_	_
17	by	by	ADP	IN	_	_	_	_	_
18	high	high	ADJ	JJ	Degree=Pos	_	_	_	_
19	doses	dos	NOUN	NNS	Number=Plur	_	_	_	_
20	of	of	ADP	IN	_	_	_	_	_
21	specific	specific	ADJ	JJ	Degree=Pos	_	_	_	_
22	peptide	peptide	NOUN	NN	Number=Sing	_	_	_	_
23	results	result	NOUN	NNS	Number=Plur	_	_	_	_
24	in	in	ADP	IN	_	_	_	_	_
25	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
26	induction	induction	NOUN	NN	Number=Sing	_	_	_	_
27	of	of	ADP	IN	_	_	_	_	_
28	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
29	long	long	ADV	RB	Degree=Pos	_	_	_	SpaceAfter=No
30	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
31	lived	live	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
32	state	state	NOUN	NN	Number=Sing	_	_	_	_
33	of	of	ADP	IN	_	_	_	_	_
34	nonresponsiveness	nonresponsiveness	NOUN	NN	Number=Sing	_	_	_	_
35	that	that	PRON	WDT	PronType=Rel	_	_	_	_
36	has	have	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
37	been	be	AUX	VBN	Tense=Past|VerbForm=Part	_	_	_	_
38	called	call	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
39	anergy	anergy	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
40	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1494
# text = During the induction of anergy, T cells are phenotypically similar to cells responding to an immunogenic stimulus.
1	During	during	ADP	IN	_	_	_	_	_
2	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
3	induction	induction	NOUN	NN	Number=Sing	_	_	_	_
4	of	of	ADP	IN	_	_	_	_	_
5	anergy	anergy	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
6	,	,	PUNCT	,	_	_	_	_	_
7	T	t	NUM	CD	NumType=Card	_	_	_	_
8	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
9	are	be	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
10	phenotypically	phenotypically	ADV	RB	_	_	_	_	_
11	similar	similar	ADJ	JJ	Degree=Pos	_	_	_	_
12	to	to	ADP	IN	_	_	_	_	_
13	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
14	responding	respond	VERB	VBG	VerbForm=Ger	_	_	_	_
15	to	to	ADP	IN	_	_	_	_	_
16	an	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
17	immunogenic	immunogenic	ADJ	JJ	Degree=Pos	_	_	_	_
18	stimulus	stimulus	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
19	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1495
# text = The amount of TcR at the cell surface is downmodulated, whereas the CD2 and CD25 receptors are increased.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	amount	amount	NOUN	NN	Number=Sing	_	_	_	_
3	of	of	ADP	IN	_	_	_	_	_
4	TcR	TcR	NOUN	NN	Number=Sing	_	_	_	_
5	at	at	ADP	IN	_	_	_	_	_
6	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
7	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
8	surface	surface	NOUN	NN	Number=Sing	_	_	_	_
9	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
10	downmodulated	downmodulate	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	SpaceAfter=No
11	,	,	PUNCT	,	_	_	_	_	_
12	whereas	whereas	SCONJ	IN	_	_	_	_	_
13	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
14	CD2	Cd2	NOUN	NN	Number=Sing	_	_	_	_
15	and	and	CCONJ	CC	_	_	_	_	_
16	CD25	Cd25	NUM	CD	NumType=Card	_	_	_	_
17	receptors	receptor	NOUN	NNS	Number=Plur	_	_	_	_
18	are	be	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
19	increased	increase	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	SpaceAfter=No
20	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1496
# text = When restimulated, however, anergic T cells fail to up-regulate transcription of the IL-2 gene and in consequence do not produce IL-2.
1	When	when	ADV	WRB	PronType=Int	_	_	_	_
2	restimulated	restimulate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	SpaceAfter=No
3	,	,	PUNCT	,	_	_	_	_	_
4	however	however	ADV	RB	_	_	_	_	SpaceAfter=No
5	,	,	PUNCT	,	_	_	_	_	_
6	anergic	anergic	ADJ	JJ	Degree=Pos	_	_	_	_
7	T	t	PROPN	NNP	Number=Sing	_	_	_	_
8	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
9	fail	fail	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
10	to	to	ADP	IN	_	_	_	_	_
11	up	up	ADV	RB	_	_	_	_	SpaceAfter=No
12	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
13	regulate	regulate	ADJ	JJ	Degree=Pos	_	_	_	_
14	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
15	of	of	ADP	IN	_	_	_	_	_
16	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
17	IL	Il	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
18	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
19	2	2	NUM	CD	NumType=Card	_	_	_	_
20	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
21	and	and	CCONJ	CC	_	_	_	_	_
22	in	in	ADP	IN	_	_	_	_	_
23	consequence	consequence	NOUN	NN	Number=Sing	_	_	_	_
24	do	do	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
25	not	not	PART	RB	_	_	_	_	_
26	produce	produce	VERB	VB	VerbForm=Inf	_	_	_	_
27	IL	il	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
28	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
29	2	2	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
30	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1497
# text = In this study, we have compared the ability of various transcription factors to bind to their appropriate site on DNA.
1	In	in	ADP	IN	_	_	_	_	_
2	this	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
3	study	study	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
4	,	,	PUNCT	,	_	_	_	_	_
5	we	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
6	have	have	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
7	compared	compare	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
8	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
9	ability	ability	NOUN	NN	Number=Sing	_	_	_	_
10	of	of	ADP	IN	_	_	_	_	_
11	various	various	ADJ	JJ	Degree=Pos	_	_	_	_
12	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
13	factors	factor	NOUN	NNS	Number=Plur	_	_	_	_
14	to	to	PART	TO	_	_	_	_	_
15	bind	bind	VERB	VB	VerbForm=Inf	_	_	_	_
16	to	to	ADP	IN	_	_	_	_	_
17	their	they	PRON	PRP$	Number=Plur|Person=3|Poss=Yes|PronType=Prs	_	_	_	_
18	appropriate	appropriate	ADJ	JJ	Degree=Pos	_	_	_	_
19	site	site	NOUN	NN	Number=Sing	_	_	_	_
20	on	on	ADP	IN	_	_	_	_	_
21	DNA	dna	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
22	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1498
# text = Factors were isolated from the nuclei of T cells that were in the induction phase of anergy or were undergoing activation.
1	Factors	factor	NOUN	NNS	Number=Plur	_	_	_	_
2	were	be	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
3	isolated	isolate	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
4	from	from	ADP	IN	_	_	_	_	_
5	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
6	nuclei	nuclei	NOUN	NN	Number=Sing	_	_	_	_
7	of	of	ADP	IN	_	_	_	_	_
8	T	t	PROPN	NNP	Number=Sing	_	_	_	_
9	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
10	that	that	PRON	WDT	PronType=Rel	_	_	_	_
11	were	be	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
12	in	in	ADP	IN	_	_	_	_	_
13	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
14	induction	induction	NOUN	NN	Number=Sing	_	_	_	_
15	phase	phase	NOUN	NN	Number=Sing	_	_	_	_
16	of	of	ADP	IN	_	_	_	_	_
17	anergy	anergy	NOUN	NN	Number=Sing	_	_	_	_
18	or	or	CCONJ	CC	_	_	_	_	_
19	were	be	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
20	undergoing	undergoing	VERB	VBG	Tense=Pres|VerbForm=Part	_	_	_	_
21	activation	activation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
22	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1499
# text = The pattern of binding activity in restimulated T cells is consistent with the pattern that has previously been shown to regulate T-cell-specific expression of the IL-2 and the beta chain of the TcR genes.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	pattern	pattern	NOUN	NN	Number=Sing	_	_	_	_
3	of	of	SCONJ	IN	_	_	_	_	_
4	binding	bind	VERB	VBG	VerbForm=Ger	_	_	_	_
5	activity	activity	NOUN	NN	Number=Sing	_	_	_	_
6	in	in	ADP	IN	_	_	_	_	_
7	restimulated	restimulate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
8	T	t	PROPN	NNP	Number=Sing	_	_	_	_
9	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
10	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
11	consistent	consistent	ADJ	JJ	Degree=Pos	_	_	_	_
12	with	with	ADP	IN	_	_	_	_	_
13	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
14	pattern	pattern	NOUN	NN	Number=Sing	_	_	_	_
15	that	that	PRON	WDT	PronType=Rel	_	_	_	_
16	has	have	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
17	previously	previously	ADV	RB	_	_	_	_	_
18	been	be	AUX	VBN	Tense=Past|VerbForm=Part	_	_	_	_
19	shown	show	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
20	to	to	PART	TO	_	_	_	_	_
21	regulate	regulate	VERB	VB	VerbForm=Inf	_	_	_	_
22	T-cell	T-cell	ADV	RB	Degree=Pos	_	_	_	SpaceAfter=No
23	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
24	specific	specific	ADJ	JJ	Degree=Pos	_	_	_	_
25	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
26	of	of	ADP	IN	_	_	_	_	_
27	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
28	IL	Il	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
29	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
30	2	2	NUM	CD	NumType=Card	_	_	_	_
31	and	and	CCONJ	CC	_	_	_	_	_
32	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
33	beta	beta	NOUN	NN	Number=Sing	_	_	_	_
34	chain	chain	NOUN	NN	Number=Sing	_	_	_	_
35	of	of	ADP	IN	_	_	_	_	_
36	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
37	TcR	Tcr	NOUN	NN	Number=Sing	_	_	_	_
38	genes	gene	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
39	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1500
# text = The measured binding to a TCF-1 site is the same in the nuclei of resting, activated, and anergized cells.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	measured	measure	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
3	binding	binding	VERB	VBG	VerbForm=Ger	_	_	_	_
4	to	to	ADP	IN	_	_	_	_	_
5	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
6	TCF	TCF	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
7	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
8	1	1	NUM	CD	NumType=Card	_	_	_	_
9	site	site	NOUN	NN	Number=Sing	_	_	_	_
10	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
11	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
12	same	same	ADJ	JJ	Degree=Pos	_	_	_	_
13	in	in	ADP	IN	_	_	_	_	_
14	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
15	nuclei	nuclei	NOUN	NN	Number=Sing	_	_	_	_
16	of	of	ADP	IN	_	_	_	_	_
17	resting	resting	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
18	,	,	PUNCT	,	_	_	_	_	_
19	activated	activate	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	SpaceAfter=No
20	,	,	PUNCT	,	_	_	_	_	_
21	and	and	CCONJ	CC	_	_	_	_	_
22	anergized	anergize	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
23	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
24	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1501
# text = The inducible factors NK-kappa B, beta E2, CD28RC, and AP-1 are not expressed in resting cells and are twofold lower in anergized as compared with activated cells.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	inducible	inducible	ADJ	JJ	Degree=Pos	_	_	_	_
3	factors	factor	NOUN	NNS	Number=Plur	_	_	_	_
4	NK	NK	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
5	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
6	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_
7	B	b	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
8	,	,	PUNCT	,	_	_	_	_	_
9	beta	beta	NOUN	NN	Number=Sing	_	_	_	_
10	E2	E2	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
11	,	,	PUNCT	,	_	_	_	_	_
12	CD28RC	CD28RC	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
13	,	,	PUNCT	,	_	_	_	_	_
14	and	and	CCONJ	CC	_	_	_	_	_
15	AP	ap	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
16	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
17	1	1	NUM	CD	NumType=Card	_	_	_	_
18	are	be	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
19	not	not	PART	RB	_	_	_	_	_
20	expressed	express	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
21	in	in	ADP	IN	_	_	_	_	_
22	resting	rest	VERB	VBG	VerbForm=Ger	_	_	_	_
23	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
24	and	and	CCONJ	CC	_	_	_	_	_
25	are	be	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
26	twofold	twofold	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
27	lower	lower	ADJ	JJR	Degree=Cmp	_	_	_	_
28	in	in	ADP	IN	_	_	_	_	_
29	anergized	anergize	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
30	as	as	ADP	IN	_	_	_	_	_
31	compared	compare	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
32	with	with	ADP	IN	_	_	_	_	_
33	activated	activate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
34	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
35	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1502
# text = In contrast, anergic T cells express approximately eightfold lower amounts of NF-AT, a member of the class of inducible factors that regulates IL-2 gene transcription.
1	In	in	ADP	IN	_	_	_	_	_
2	contrast	contrast	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
3	,	,	PUNCT	,	_	_	_	_	_
4	anergic	anergic	ADJ	JJ	Degree=Pos	_	_	_	_
5	T	t	PROPN	NNP	Number=Sing	_	_	_	_
6	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
7	express	express	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
8	approximately	approximately	ADV	RB	_	_	_	_	_
9	eightfold	eightfold	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
10	lower	lower	ADJ	JJR	Degree=Cmp	_	_	_	_
11	amounts	amount	NOUN	NNS	Number=Plur	_	_	_	_
12	of	of	ADP	IN	_	_	_	_	_
13	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
14	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
15	AT	AT	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
16	,	,	PUNCT	,	_	_	_	_	_
17	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
18	member	member	NOUN	NN	Number=Sing	_	_	_	_
19	of	of	ADP	IN	_	_	_	_	_
20	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
21	class	class	NOUN	NN	Number=Sing	_	_	_	_
22	of	of	ADP	IN	_	_	_	_	_
23	inducible	inducible	ADJ	JJ	Degree=Pos	_	_	_	_
24	factors	factor	NOUN	NNS	Number=Plur	_	_	_	_
25	that	that	PRON	WDT	PronType=Rel	_	_	_	_
26	regulates	regulate	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
27	IL	Il	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
28	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
29	2	2	NUM	CD	NumType=Card	_	_	_	_
30	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
31	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
32	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1503
# text = (ABSTRACT TRUNCATED AT 250 WORDS)
1	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
2	ABSTRACT	ABSTRACT	X	GW	_	_	_	_	_
3	TRUNCATED	Truncate	VERB	VB	Mood=Imp|VerbForm=Fin	_	_	_	_
4	AT	at	ADV	RB	_	_	_	_	_
5	250	250	NUM	CD	NumType=Card	_	_	_	_
6	WORDS	words	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
7	)	)	PUNCT	-RRB-	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 1504
# text = Document 003002549 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	003002549	003002549	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 1505
# text = The p53 paradox in the pathogenesis of tumor progression.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	p53	p53	NOUN	NN	Number=Sing	_	_	_	_
3	paradox	paradox	NOUN	NN	Number=Sing	_	_	_	_
4	in	in	ADP	IN	_	_	_	_	_
5	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
6	pathogenesis	pathogenesis	NOUN	NN	Number=Sing	_	_	_	_
7	of	of	ADP	IN	_	_	_	_	_
8	tumor	tumor	NOUN	NN	Number=Sing	_	_	_	_
9	progression	progression	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
10	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 1506
# text = Recent evidence suggests that the p53 molecule appears in two different forms: the mutant p53 that stimulates tumor progression, and wild type p53 that inhibits tumor progression.
1	Recent	recent	ADJ	JJ	Degree=Pos	_	_	_	_
2	evidence	evidence	NOUN	NN	Number=Sing	_	_	_	_
3	suggests	suggest	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
4	that	that	SCONJ	IN	_	_	_	_	_
5	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
6	p53	p53	NOUN	NN	Number=Sing	_	_	_	_
7	molecule	molecule	NOUN	NN	Number=Sing	_	_	_	_
8	appears	appear	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
9	in	in	ADP	IN	_	_	_	_	_
10	two	two	NUM	CD	NumType=Card	_	_	_	_
11	different	different	ADJ	JJ	Degree=Pos	_	_	_	_
12	forms	form	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
13	:	:	PUNCT	:	_	_	_	_	_
14	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
15	mutant	mutant	ADJ	JJ	Degree=Pos	_	_	_	_
16	p53	p53	NOUN	NN	Number=Sing	_	_	_	_
17	that	that	PRON	WDT	PronType=Rel	_	_	_	_
18	stimulates	stimulate	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
19	tumor	tumor	NOUN	NN	Number=Sing	_	_	_	_
20	progression	progression	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
21	,	,	PUNCT	,	_	_	_	_	_
22	and	and	CCONJ	CC	_	_	_	_	_
23	wild	wild	ADJ	JJ	Degree=Pos	_	_	_	_
24	type	type	NOUN	NN	Number=Sing	_	_	_	_
25	p53	p53	NOUN	NN	Number=Sing	_	_	_	_
26	that	that	PRON	WDT	PronType=Rel	_	_	_	_
27	inhibits	inhibit	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
28	tumor	tumor	NOUN	NN	Number=Sing	_	_	_	_
29	progression	progression	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
30	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1507
# text = In addition, it has been established that tumor necrosis factor-alpha (TNF-alpha) can activate the expression of wild type p53 in concert with the nuclear transcription factor, NF-kappa B.
1	In	in	ADP	IN	_	_	_	_	_
2	addition	addition	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
3	,	,	PUNCT	,	_	_	_	_	_
4	it	it	PRON	PRP	Case=Nom|Gender=Neut|Number=Sing|Person=3|PronType=Prs	_	_	_	_
5	has	have	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
6	been	be	AUX	VBN	Tense=Past|VerbForm=Part	_	_	_	_
7	established	establish	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
8	that	that	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
9	tumor	tumor	NOUN	NN	Number=Sing	_	_	_	_
10	necrosis	necrosis	NOUN	NN	Number=Sing	_	_	_	_
11	factor	factor	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
12	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
13	alpha	alpha	NOUN	NN	Number=Sing	_	_	_	_
14	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
15	TNF	Tnf	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
16	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
17	alpha	alpha	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
18	)	)	PUNCT	-RRB-	_	_	_	_	_
19	can	can	AUX	MD	VerbForm=Fin	_	_	_	_
20	activate	activate	VERB	VB	VerbForm=Inf	_	_	_	_
21	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
22	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
23	of	of	ADP	IN	_	_	_	_	_
24	wild	wild	ADJ	JJ	Degree=Pos	_	_	_	_
25	type	type	NOUN	NN	Number=Sing	_	_	_	_
26	p53	p53	NOUN	NN	Number=Sing	_	_	_	_
27	in	in	ADP	IN	_	_	_	_	_
28	concert	concert	NOUN	NN	Number=Sing	_	_	_	_
29	with	with	ADP	IN	_	_	_	_	_
30	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
31	nuclear	nuclear	ADJ	JJ	Degree=Pos	_	_	_	_
32	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
33	factor	factor	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
34	,	,	PUNCT	,	_	_	_	_	_
35	NF	Nf	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
36	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
37	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_
38	B	b	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
39	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1508
# text = Both TNF-alpha and NF-kappa B are also involved in the stimulation of the pathway that leads to the expression of major histocompatibility complex (MHC) class I molecules and, hence, antigen presentation to the T cells.
1	Both	both	DET	DT	_	_	_	_	_
2	TNF	Tnf	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
3	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
4	alpha	alpha	NOUN	NN	Number=Sing	_	_	_	_
5	and	and	CCONJ	CC	_	_	_	_	_
6	NF	Nf	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
7	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
8	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_
9	B	b	NOUN	NN	Number=Sing	_	_	_	_
10	are	be	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
11	also	also	ADV	RB	_	_	_	_	_
12	involved	involved	ADJ	JJ	Degree=Pos	_	_	_	_
13	in	in	ADP	IN	_	_	_	_	_
14	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
15	stimulation	stimulation	NOUN	NN	Number=Sing	_	_	_	_
16	of	of	ADP	IN	_	_	_	_	_
17	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
18	pathway	pathway	NOUN	NN	Number=Sing	_	_	_	_
19	that	that	PRON	WDT	PronType=Rel	_	_	_	_
20	leads	lead	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
21	to	to	ADP	IN	_	_	_	_	_
22	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
23	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
24	of	of	ADP	IN	_	_	_	_	_
25	major	major	ADJ	JJ	Degree=Pos	_	_	_	_
26	histocompatibility	histocompatibility	NOUN	NN	Number=Sing	_	_	_	_
27	complex	complex	NOUN	NN	Number=Sing	_	_	_	_
28	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
29	MHC	MHC	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
30	)	)	PUNCT	-RRB-	_	_	_	_	_
31	class	class	NOUN	NN	Number=Sing	_	_	_	_
32	I	I	PRON	PRP	Case=Nom|Number=Sing|Person=1|PronType=Prs	_	_	_	_
33	molecules	molecule	NOUN	NNS	Number=Plur	_	_	_	_
34	and	and	CCONJ	CC	_	_	_	_	SpaceAfter=No
35	,	,	PUNCT	,	_	_	_	_	_
36	hence	hence	ADV	RB	_	_	_	_	SpaceAfter=No
37	,	,	PUNCT	,	_	_	_	_	_
38	antigen	antigen	ADJ	JJ	Degree=Pos	_	_	_	_
39	presentation	presentation	NOUN	NN	Number=Sing	_	_	_	_
40	to	to	ADP	IN	_	_	_	_	_
41	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
42	T	t	PROPN	NNP	Number=Sing	_	_	_	_
43	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
44	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1509
# text = In this paper we shall advance the hypothesis that: (i) TNF-alpha indirectly controls immune surveillance; and (ii) TNF-alpha controls DNA repair and tumor suppression through the regulation of wild type p53.
1	In	in	ADP	IN	_	_	_	_	_
2	this	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
3	paper	paper	NOUN	NN	Number=Sing	_	_	_	_
4	we	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
5	shall	shall	AUX	MD	VerbForm=Fin	_	_	_	_
6	advance	advance	VERB	VB	VerbForm=Inf	_	_	_	_
7	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
8	hypothesis	hypothesis	NOUN	NN	Number=Sing	_	_	_	_
9	that	that	PRON	WDT	PronType=Rel	_	_	_	SpaceAfter=No
10	:	:	PUNCT	:	_	_	_	_	_
11	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
12	i	i	X	LS	_	_	_	_	SpaceAfter=No
13	)	)	PUNCT	-RRB-	_	_	_	_	_
14	TNF	Tnf	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
15	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
16	alpha	alpha	NOUN	NN	Number=Sing	_	_	_	_
17	indirectly	indirectly	ADV	RB	_	_	_	_	_
18	controls	control	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
19	immune	immune	ADJ	JJ	Degree=Pos	_	_	_	_
20	surveillance	surveillance	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
21	;	;	PUNCT	,	_	_	_	_	_
22	and	and	CCONJ	CC	_	_	_	_	_
23	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
24	ii	ii	X	LS	_	_	_	_	SpaceAfter=No
25	)	)	PUNCT	-RRB-	_	_	_	_	_
26	TNF	Tnf	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
27	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
28	alpha	alpha	NOUN	NN	Number=Sing	_	_	_	_
29	controls	controls	NOUN	NN	Number=Sing	_	_	_	_
30	DNA	dna	NOUN	NN	Number=Sing	_	_	_	_
31	repair	repair	NOUN	NN	Number=Sing	_	_	_	_
32	and	and	CCONJ	CC	_	_	_	_	_
33	tumor	tumor	NOUN	NN	Number=Sing	_	_	_	_
34	suppression	suppression	NOUN	NN	Number=Sing	_	_	_	_
35	through	through	ADP	IN	_	_	_	_	_
36	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
37	regulation	regulation	NOUN	NN	Number=Sing	_	_	_	_
38	of	of	ADP	IN	_	_	_	_	_
39	wild	wild	ADJ	JJ	Degree=Pos	_	_	_	_
40	type	type	NOUN	NN	Number=Sing	_	_	_	_
41	p53	p53	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
42	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1510
# text = Thus, it is hypothesized that elevated TNF-alpha is primarily responsible for promoting tumor progression.
1	Thus	thus	ADV	RB	_	_	_	_	SpaceAfter=No
2	,	,	PUNCT	,	_	_	_	_	_
3	it	it	PRON	PRP	Case=Nom|Gender=Neut|Number=Sing|Person=3|PronType=Prs	_	_	_	_
4	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
5	hypothesized	hypothesize	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
6	that	that	SCONJ	IN	_	_	_	_	_
7	elevated	elevate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
8	TNF	TNF	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
9	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
10	alpha	alpha	NOUN	NN	Number=Sing	_	_	_	_
11	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
12	primarily	primarily	ADV	RB	_	_	_	_	_
13	responsible	responsible	ADJ	JJ	Degree=Pos	_	_	_	_
14	for	for	SCONJ	IN	_	_	_	_	_
15	promoting	promote	VERB	VBG	VerbForm=Ger	_	_	_	_
16	tumor	tumor	NOUN	NN	Number=Sing	_	_	_	_
17	progression	progression	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
18	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 1511
# text = Document 003002554 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	003002554	003002554	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 1512
# text = Human T lymphotropic virus-I infection of human T lymphocytes induces expression of the beta-galactoside-binding lectin, galectin-3.
1	Human	human	PROPN	NNP	Number=Sing	_	_	_	_
2	T	t	PROPN	NNP	Number=Sing	_	_	_	_
3	lymphotropic	lymphotropic	ADJ	JJ	Degree=Pos	_	_	_	_
4	virus	virus	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
5	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
6	I	I	PRON	PRP	Case=Nom|Number=Sing|Person=1|PronType=Prs	_	_	_	_
7	infection	infection	NOUN	NN	Number=Sing	_	_	_	_
8	of	of	ADP	IN	_	_	_	_	_
9	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
10	T	T	PROPN	NNP	Number=Sing	_	_	_	_
11	lymphocytes	lymphocyte	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
12	induces	induce	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
13	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
14	of	of	ADP	IN	_	_	_	_	_
15	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
16	beta	beta	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
17	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
18	galactoside-binding	galactoside-binding	NOUN	NN	Number=Sing	_	_	_	_
19	lectin	lectin	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
20	,	,	PUNCT	,	_	_	_	_	_
21	galectin	galectin	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
22	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
23	3	3	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
24	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 1513
# text = Animal lectins play important roles in a variety of biological processes via their recognition of glycoconjugates.
1	Animal	animal	ADJ	JJ	Degree=Pos	_	_	_	_
2	lectins	lectin	NOUN	NNS	Number=Plur	_	_	_	_
3	play	play	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
4	important	important	ADJ	JJ	Degree=Pos	_	_	_	_
5	roles	role	NOUN	NNS	Number=Plur	_	_	_	_
6	in	in	ADP	IN	_	_	_	_	_
7	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
8	variety	variety	NOUN	NN	Number=Sing	_	_	_	_
9	of	of	ADP	IN	_	_	_	_	_
10	biological	biological	ADJ	JJ	Degree=Pos	_	_	_	_
11	processes	process	NOUN	NNS	Number=Plur	_	_	_	_
12	via	via	ADP	IN	_	_	_	_	_
13	their	they	PRON	PRP$	Number=Plur|Person=3|Poss=Yes|PronType=Prs	_	_	_	_
14	recognition	recognition	NOUN	NN	Number=Sing	_	_	_	_
15	of	of	ADP	IN	_	_	_	_	_
16	glycoconjugates	glycoconjugate	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
17	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1514
# text = Galectin-3 is a beta-galactoside-binding lectin previously designated as epsilon BP (IgE-binding protein), CBP35, Mac-2, L-29, and L-34, and its expression has been associated with various physiological and pathological processes, including cell growth, tumor transformation, and metastasis.
1	Galectin	Galectin	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
2	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
3	3	3	NUM	CD	NumType=Card	_	_	_	_
4	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
5	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
6	beta	beta	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
7	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
8	galactoside	galactoside	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
9	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
10	binding	binding	VERB	VBG	VerbForm=Ger	_	_	_	_
11	lectin	lectin	NOUN	NN	Number=Sing	_	_	_	_
12	previously	previously	ADV	RB	_	_	_	_	_
13	designated	designate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
14	as	as	ADV	RB	_	_	_	_	_
15	epsilon	epsilon	ADP	IN	_	_	_	_	_
16	BP	BP	PROPN	NNP	Number=Sing	_	_	_	_
17	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
18	IgE	Ige	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
19	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
20	binding	binding	VERB	VBG	VerbForm=Ger	_	_	_	_
21	protein	protein	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
22	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
23	,	,	PUNCT	,	_	_	_	_	_
24	CBP35	CBP35	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
25	,	,	PUNCT	,	_	_	_	_	_
26	Mac	Mac	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
27	-2	-2	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
28	,	,	PUNCT	,	_	_	_	_	_
29	L	L	SYM	$	_	_	_	_	SpaceAfter=No
30	-	-	SYM	SYM	_	_	_	_	SpaceAfter=No
31	29	29	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
32	,	,	PUNCT	,	_	_	_	_	_
33	and	and	CCONJ	CC	_	_	_	_	_
34	L	l	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
35	-34	-34	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
36	,	,	PUNCT	,	_	_	_	_	_
37	and	and	CCONJ	CC	_	_	_	_	_
38	it	it	PRON	PRP	Case=Nom|Gender=Neut|Number=Sing|Person=3|PronType=Prs	_	_	_	SpaceAfter=No
39	s	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
40	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
41	has	have	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
42	been	be	AUX	VBN	Tense=Past|VerbForm=Part	_	_	_	_
43	associated	associate	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
44	with	with	ADP	IN	_	_	_	_	_
45	various	various	ADJ	JJ	Degree=Pos	_	_	_	_
46	physiological	physiological	ADJ	JJ	Degree=Pos	_	_	_	_
47	and	and	CCONJ	CC	_	_	_	_	_
48	pathological	pathological	ADJ	JJ	Degree=Pos	_	_	_	_
49	processes	process	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
50	,	,	PUNCT	,	_	_	_	_	_
51	including	include	VERB	VBG	VerbForm=Ger	_	_	_	_
52	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
53	growth	growth	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
54	,	,	PUNCT	,	_	_	_	_	_
55	tumor	tumor	NOUN	NN	Number=Sing	_	_	_	_
56	transformation	transformation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
57	,	,	PUNCT	,	_	_	_	_	_
58	and	and	CCONJ	CC	_	_	_	_	_
59	metastasis	metastasis	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
60	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1515
# text = Galectin-3 is widely distributed in various tissues and cell types and is expressed in many leukocytes, with the notable exception of B and T lymphocytes.
1	Galectin	Galectin	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
2	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
3	3	3	NUM	CD	NumType=Card	_	_	_	_
4	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
5	widely	widely	ADV	RB	_	_	_	_	_
6	distributed	distribute	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
7	in	in	ADP	IN	_	_	_	_	_
8	various	various	ADJ	JJ	Degree=Pos	_	_	_	_
9	tissues	tissue	NOUN	NNS	Number=Plur	_	_	_	_
10	and	and	CCONJ	CC	_	_	_	_	_
11	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
12	types	type	NOUN	NNS	Number=Plur	_	_	_	_
13	and	and	CCONJ	CC	_	_	_	_	_
14	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
15	expressed	express	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
16	in	in	ADP	IN	_	_	_	_	_
17	many	many	ADJ	JJ	Degree=Pos	_	_	_	_
18	leukocytes	leukocyte	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
19	,	,	PUNCT	,	_	_	_	_	_
20	with	with	ADP	IN	_	_	_	_	_
21	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
22	notable	notable	ADJ	JJ	Degree=Pos	_	_	_	_
23	exception	exception	NOUN	NN	Number=Sing	_	_	_	_
24	of	of	ADP	IN	_	_	_	_	_
25	B	b	PROPN	NNP	Number=Sing	_	_	_	_
26	and	and	CCONJ	CC	_	_	_	_	_
27	T	t	PROPN	NNP	Number=Sing	_	_	_	_
28	lymphocytes	lymphocyte	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
29	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1516
# text = We now report that galectin-3 is abundantly expressed in a number of human T lymphotropic virus (HTLV)-I-infected human T cell lines, including F6T, HUT 102, K3T, MT-2, and SLB-I, but is not expressed in non-HTLV-I-infected T cell lines such as Jurkat, CEM, and MOLT-4.
1	We	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
2	now	now	ADV	RB	_	_	_	_	_
3	report	report	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
4	that	that	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
5	galectin	galectin	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
6	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
7	3	3	NUM	CD	NumType=Card	_	_	_	_
8	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
9	abundantly	abundantly	ADV	RB	_	_	_	_	_
10	expressed	express	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
11	in	in	ADP	IN	_	_	_	_	_
12	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
13	number	number	NOUN	NN	Number=Sing	_	_	_	_
14	of	of	ADP	IN	_	_	_	_	_
15	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
16	T	t	PROPN	NNP	Number=Sing	_	_	_	_
17	lymphotropic	lymphotropic	ADJ	JJ	Degree=Pos	_	_	_	_
18	virus	virus	NOUN	NN	Number=Sing	_	_	_	_
19	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
20	HTLV	HTLV	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
21	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
22	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
23	I	I	PRON	PRP	Case=Nom|Number=Sing|Person=1|PronType=Prs	_	_	_	SpaceAfter=No
24	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
25	infected	infect	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
26	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
27	T	t	NOUN	NN	Number=Sing	_	_	_	_
28	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
29	lines	line	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
30	,	,	PUNCT	,	_	_	_	_	_
31	including	include	VERB	VBG	VerbForm=Ger	_	_	_	_
32	F6T	F6T	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
33	,	,	PUNCT	,	_	_	_	_	_
34	HUT	Hut	PROPN	NNP	Number=Sing	_	_	_	_
35	102	102	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
36	,	,	PUNCT	,	_	_	_	_	_
37	K3T	K3T	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
38	,	,	PUNCT	,	_	_	_	_	_
39	MT	Mt	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
40	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
41	2	2	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
42	,	,	PUNCT	,	_	_	_	_	_
43	and	and	CCONJ	CC	_	_	_	_	_
44	SLB	SLB	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
45	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
46	I	I	PRON	PRP	Case=Nom|Number=Sing|Person=1|PronType=Prs	_	_	_	SpaceAfter=No
47	,	,	PUNCT	,	_	_	_	_	_
48	but	but	CCONJ	CC	_	_	_	_	_
49	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
50	not	not	PART	RB	_	_	_	_	_
51	expressed	express	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
52	in	in	ADP	IN	_	_	_	_	_
53	non-HTLV	non-HTLV	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
54	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
55	I	I	PRON	PRP	Case=Nom|Number=Sing|Person=1|PronType=Prs	_	_	_	SpaceAfter=No
56	-infected	-infect	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
57	T	t	PROPN	NNP	Number=Sing	_	_	_	_
58	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
59	lines	line	NOUN	NNS	Number=Plur	_	_	_	_
60	such	such	ADJ	JJ	Degree=Pos	_	_	_	_
61	as	as	ADP	IN	_	_	_	_	_
62	Jurkat	Jurkat	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
63	,	,	PUNCT	,	_	_	_	_	_
64	CEM	CEM	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
65	,	,	PUNCT	,	_	_	_	_	_
66	and	and	CCONJ	CC	_	_	_	_	_
67	MOLT	Molt	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
68	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
69	4	4	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
70	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1517
# text = In addition, the galectin-3 level was markedly increased in human thymocytes after infection with HTLV-I as compared with uninfected thymocytes.
1	In	in	ADP	IN	_	_	_	_	_
2	addition	addition	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
3	,	,	PUNCT	,	_	_	_	_	_
4	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
5	galectin	galectin	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
6	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
7	3	3	NUM	CD	NumType=Card	_	_	_	_
8	level	level	NOUN	NN	Number=Sing	_	_	_	_
9	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
10	markedly	markedly	ADV	RB	_	_	_	_	_
11	increased	increase	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
12	in	in	ADP	IN	_	_	_	_	_
13	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
14	thymocytes	thymocyte	NOUN	NNS	Number=Plur	_	_	_	_
15	after	after	ADP	IN	_	_	_	_	_
16	infection	infection	NOUN	NN	Number=Sing	_	_	_	_
17	with	with	ADP	IN	_	_	_	_	_
18	HTLV	HTLV	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
19	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
20	I	I	PRON	PRP	Case=Nom|Number=Sing|Person=1|PronType=Prs	_	_	_	_
21	as	as	AUX	VBP	Mood=Ind|Tense=Pres|Typo=Yes|VerbForm=Fin	_	_	_	_
22	compared	compare	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
23	with	with	ADP	IN	_	_	_	_	_
24	uninfected	uninfect	ADJ	JJ	Degree=Pos	_	_	_	_
25	thymocytes	thymocyte	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
26	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1518
# text = The up-regulation of galectin-3 expression appeared to correlate well with HTLV-I gene expression, as undetectable or very low levels of galectin-3 were found in the S1T and ATL-1K cell lines, which are nonproductively infected with HTLV-I.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	up	up	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
3	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
4	regulation	regulation	NOUN	NN	Number=Sing	_	_	_	_
5	of	of	ADP	IN	_	_	_	_	_
6	galectin	galectin	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
7	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
8	3	3	NUM	CD	NumType=Card	_	_	_	_
9	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
10	appeared	appear	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
11	to	to	PART	TO	_	_	_	_	_
12	correlate	correlate	VERB	VB	VerbForm=Inf	_	_	_	_
13	well	well	ADV	RB	Degree=Pos	_	_	_	_
14	with	with	ADP	IN	_	_	_	_	_
15	HTLV	HTLV	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
16	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
17	I	I	PRON	PRP	Case=Nom|Number=Sing|Person=1|PronType=Prs	_	_	_	_
18	gene	gene	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
19	expression	expression	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
20	,	,	PUNCT	,	_	_	_	_	_
21	as	as	SCONJ	IN	_	_	_	_	_
22	undetectable	undetectable	ADJ	JJ	Degree=Pos	_	_	_	_
23	or	or	CCONJ	CC	_	_	_	_	_
24	very	very	ADV	RB	_	_	_	_	_
25	low	low	ADJ	JJ	Degree=Pos	_	_	_	_
26	levels	level	NOUN	NNS	Number=Plur	_	_	_	_
27	of	of	ADP	IN	_	_	_	_	_
28	galectin	galectin	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
29	-3	-3	NUM	CD	NumType=Card	_	_	_	_
30	were	be	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
31	found	find	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
32	in	in	ADP	IN	_	_	_	_	_
33	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
34	S1T	S1T	NOUN	NN	Number=Sing	_	_	_	_
35	and	and	CCONJ	CC	_	_	_	_	_
36	ATL	ATL	ADV	RB	_	_	_	_	SpaceAfter=No
37	-	-	SYM	SYM	_	_	_	_	SpaceAfter=No
38	1	1	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
39	K	k	NUM	CD	NumType=Card	_	_	_	_
40	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
41	lines	line	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
42	,	,	PUNCT	,	_	_	_	_	_
43	which	which	PRON	WDT	PronType=Rel	_	_	_	_
44	are	be	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
45	nonproductively	nonproductively	ADV	RB	_	_	_	_	_
46	infected	infect	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
47	with	with	ADP	IN	_	_	_	_	_
48	HTLV	HTLV	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
49	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
50	I	I	PRON	PRP	Case=Nom|Number=Sing|Person=1|PronType=Prs	_	_	_	SpaceAfter=No
51	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1519
# text = In co-transfection experiments, the galectin-3 promoter was significantly up-regulated by expression vectors encoding the 40-kd Tax protein, a potent transactivator in HTLV-I.
1	In	in	ADP	IN	_	_	_	_	_
2	co-transfection	co-transfection	NOUN	NN	Number=Sing	_	_	_	_
3	experiments	experiment	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	,	,	PUNCT	,	_	_	_	_	_
5	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
6	galectin	galectin	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
7	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
8	3	3	NUM	CD	NumType=Card	_	_	_	_
9	promoter	promoter	NOUN	NN	Number=Sing	_	_	_	_
10	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
11	significantly	significantly	ADV	RB	_	_	_	_	_
12	up	up	ADV	RB	_	_	_	_	SpaceAfter=No
13	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
14	regulated	regulate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
15	by	by	ADP	IN	_	_	_	_	_
16	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
17	vectors	vector	NOUN	NNS	Number=Plur	_	_	_	_
18	encoding	encod	VERB	VBG	VerbForm=Ger	_	_	_	_
19	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
20	40	40	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
21	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
22	kd	kd	NOUN	NN	Number=Sing	_	_	_	_
23	Tax	tax	NOUN	NN	Number=Sing	_	_	_	_
24	protein	protein	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
25	,	,	PUNCT	,	_	_	_	_	_
26	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
27	potent	potent	NOUN	NN	Number=Sing	_	_	_	_
28	transactivator	transactivator	NOUN	NN	Number=Sing	_	_	_	_
29	in	in	ADP	IN	_	_	_	_	_
30	HTLV	HTLV	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
31	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
32	I	I	PRON	PRP	Case=Nom|Number=Sing|Person=1|PronType=Prs	_	_	_	SpaceAfter=No
33	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1520
# text = Analysis of various Tax mutants suggested that galectin-3 promoter induction is dependent on activation of the cyclic-AMP-responsive element binding protein/activation transcription factor family of transcription factors and, to a lesser extent, nuclear factor-kappa B/Rel induction.
1	Analysis	analysis	NOUN	NN	Number=Sing	_	_	_	_
2	of	of	ADP	IN	_	_	_	_	_
3	various	various	ADJ	JJ	Degree=Pos	_	_	_	_
4	Tax	tax	PROPN	NNP	Number=Sing	_	_	_	_
5	mutants	mutant	NOUN	NNS	Number=Plur	_	_	_	_
6	suggested	suggest	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
7	that	that	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
8	galectin	galectin	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
9	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
10	3	3	NUM	CD	NumType=Card	_	_	_	_
11	promoter	promoter	NOUN	NN	Number=Sing	_	_	_	_
12	induction	induction	NOUN	NN	Number=Sing	_	_	_	_
13	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
14	dependent	dependent	ADJ	JJ	Degree=Pos	_	_	_	_
15	on	on	ADP	IN	_	_	_	_	_
16	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
17	of	of	ADP	IN	_	_	_	_	_
18	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
19	cyclic	cyclic	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
20	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
21	AMP	Amp	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
22	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
23	responsive	responsive	ADJ	JJ	Degree=Pos	_	_	_	_
24	element	element	NOUN	NN	Number=Sing	_	_	_	_
25	binding	bind	VERB	VBG	VerbForm=Ger	_	_	_	_
26	protein/	proteinith	ADP	IN	Abbr=Yes	_	_	_	SpaceAfter=No
27	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
28	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
29	factor	factor	NOUN	NN	Number=Sing	_	_	_	_
30	family	family	NOUN	NN	Number=Sing	_	_	_	_
31	of	of	ADP	IN	_	_	_	_	_
32	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
33	factors	factor	NOUN	NNS	Number=Plur	_	_	_	_
34	and	and	CCONJ	CC	_	_	_	_	SpaceAfter=No
35	,	,	PUNCT	,	_	_	_	_	_
36	to	to	ADP	IN	_	_	_	_	_
37	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
38	lesser	lesser	ADJ	JJR	Degree=Cmp	_	_	_	_
39	extent	extent	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
40	,	,	PUNCT	,	_	_	_	_	_
41	nuclear	nuclear	ADJ	JJ	Degree=Pos	_	_	_	_
42	factor	factor	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
43	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
44	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_
45	B	b	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
46	/	/	PUNCT	,	_	_	_	_	SpaceAfter=No
47	Rel	Rel	NOUN	NN	Number=Sing	_	_	_	_
48	induction	induction	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
49	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1521
# text = Transfection of human promonocytic U-937 cells with an HTLV-I Tax expression vector induced galectin-3 expression in this cell line.
1	Transfection	Transfection	NOUN	NN	Number=Sing	_	_	_	_
2	of	of	ADP	IN	_	_	_	_	_
3	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
4	promonocytic	promonocytic	ADJ	JJ	Degree=Pos	_	_	_	_
5	U	U	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
6	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
7	937	937	NUM	CD	NumType=Card	_	_	_	_
8	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
9	with	with	ADP	IN	_	_	_	_	_
10	an	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
11	HTLV	HTLV	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
12	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
13	I	I	PRON	PRP	Case=Nom|Number=Sing|Person=1|PronType=Prs	_	_	_	_
14	Tax	tax	PROPN	NNP	Number=Sing	_	_	_	_
15	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
16	vector	vector	NOUN	NN	Number=Sing	_	_	_	_
17	induced	induce	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
18	galectin	galectin	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
19	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
20	3	3	NUM	CD	NumType=Card	_	_	_	_
21	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
22	in	in	ADP	IN	_	_	_	_	_
23	this	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
24	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
25	line	line	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
26	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1522
# text = Functionally, galectin-3 was shown to activate interleukin-2 production in Jurkat T cells.
1	Functionally	functionally	ADV	RB	_	_	_	_	SpaceAfter=No
2	,	,	PUNCT	,	_	_	_	_	_
3	galectin	galectin	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
4	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
5	3	3	NUM	CD	NumType=Card	_	_	_	_
6	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
7	shown	show	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
8	to	to	PART	TO	_	_	_	_	_
9	activate	activate	VERB	VB	VerbForm=Inf	_	_	_	_
10	interleukin	interleukin	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
11	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
12	2	2	NUM	CD	NumType=Card	_	_	_	_
13	production	production	NOUN	NN	Number=Sing	_	_	_	_
14	in	in	ADP	IN	_	_	_	_	_
15	Jurkat	Jurkat	PROPN	NNP	Number=Sing	_	_	_	_
16	T	T	PROPN	NNP	Number=Sing	_	_	_	_
17	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
18	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1523
# text = Together, these findings raise the possibility that HTLV-I Tax production induces the transcription and subsequent synthesis and secretion of galectin-3, which in turn may further activate these T cells and contribute to the altered properties of cell growth found in adult T cell leukemia induced by HTLV-I.
1	Together	together	ADV	RB	_	_	_	_	SpaceAfter=No
2	,	,	PUNCT	,	_	_	_	_	_
3	these	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
4	findings	finding	NOUN	NNS	Number=Plur	_	_	_	_
5	raise	raise	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
6	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
7	possibility	possibility	NOUN	NN	Number=Sing	_	_	_	_
8	that	that	PRON	WDT	PronType=Rel	_	_	_	_
9	HTLV	HTLV	VERB	VBP	Abbr=Yes|Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	SpaceAfter=No
10	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
11	I	I	PRON	PRP	Case=Nom|Number=Sing|Person=1|PronType=Prs	_	_	_	_
12	Tax	tax	PROPN	NNP	Number=Sing	_	_	_	_
13	production	production	NOUN	NN	Number=Sing	_	_	_	_
14	induces	induce	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
15	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
16	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
17	and	and	CCONJ	CC	_	_	_	_	_
18	subsequent	subsequent	ADJ	JJ	Degree=Pos	_	_	_	_
19	synthesis	synthesis	NOUN	NN	Number=Sing	_	_	_	_
20	and	and	CCONJ	CC	_	_	_	_	_
21	secretion	secretion	NOUN	NN	Number=Sing	_	_	_	_
22	of	of	ADP	IN	_	_	_	_	_
23	galectin	galectin	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
24	-3	-3	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
25	,	,	PUNCT	,	_	_	_	_	_
26	which	which	PRON	WDT	PronType=Rel	_	_	_	_
27	in	in	ADP	IN	_	_	_	_	_
28	turn	turn	NOUN	NN	Number=Sing	_	_	_	_
29	may	may	AUX	MD	VerbForm=Fin	_	_	_	_
30	further	further	ADV	RB	_	_	_	_	_
31	activate	activate	VERB	VB	VerbForm=Inf	_	_	_	_
32	these	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
33	T	t	PROPN	NNP	Number=Sing	_	_	_	_
34	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
35	and	and	CCONJ	CC	_	_	_	_	_
36	contribute	contribute	VERB	VB	VerbForm=Inf	_	_	_	_
37	to	to	ADP	IN	_	_	_	_	_
38	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
39	altered	alter	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
40	properties	property	NOUN	NNS	Number=Plur	_	_	_	_
41	of	of	ADP	IN	_	_	_	_	_
42	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
43	growth	growth	NOUN	NN	Number=Sing	_	_	_	_
44	found	find	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
45	in	in	ADP	IN	_	_	_	_	_
46	adult	adult	ADJ	JJ	Degree=Pos	_	_	_	_
47	T	T	PROPN	NNP	Number=Sing	_	_	_	_
48	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
49	leukemia	leukemia	NOUN	NN	Number=Sing	_	_	_	_
50	induced	induce	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
51	by	by	ADP	IN	_	_	_	_	_
52	HTLV	HTLV	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
53	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
54	I	I	PRON	PRP	Case=Nom|Number=Sing|Person=1|PronType=Prs	_	_	_	SpaceAfter=No
55	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 1524
# text = Document 003002562 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	003002	003002	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
3	562	562	NUM	CD	NumType=Card	_	_	_	_
4	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
5	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 1525
# text = Initiation binding repressor, a factor that binds to the transcription initiation site of the histone h5 gene, is a glycosylated member of a family of cell growth regulators [corrected] [published erratum appears in Mol Cell Biol 1996 Feb;16(2):735]
1	Initiation	Initiation	NOUN	NN	Number=Sing	_	_	_	_
2	binding	bind	VERB	VBG	VerbForm=Ger	_	_	_	_
3	repressor	repressor	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
4	,	,	PUNCT	,	_	_	_	_	_
5	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
6	factor	factor	NOUN	NN	Number=Sing	_	_	_	_
7	that	that	PRON	WDT	PronType=Rel	_	_	_	_
8	binds	bind	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
9	to	to	ADP	IN	_	_	_	_	_
10	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
11	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
12	initiation	initiation	NOUN	NN	Number=Sing	_	_	_	_
13	site	site	NOUN	NN	Number=Sing	_	_	_	_
14	of	of	ADP	IN	_	_	_	_	_
15	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
16	histone	histone	NOUN	NN	Number=Sing	_	_	_	_
17	h5	h5	NUM	CD	NumType=Card	_	_	_	_
18	gene	gene	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
19	,	,	PUNCT	,	_	_	_	_	_
20	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
21	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
22	glycosylated	glycosylate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
23	member	member	NOUN	NN	Number=Sing	_	_	_	_
24	of	of	ADP	IN	_	_	_	_	_
25	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
26	family	family	NOUN	NN	Number=Sing	_	_	_	_
27	of	of	ADP	IN	_	_	_	_	_
28	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
29	growth	growth	NOUN	NN	Number=Sing	_	_	_	_
30	regulators	regulator	NOUN	NNS	Number=Plur	_	_	_	_
31	[	[	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
32	corrected	correct	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	SpaceAfter=No
33	]	]	PUNCT	-RRB-	_	_	_	_	_
34	[	[	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
35	published	publish	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
36	erratum	erratum	NOUN	NN	Number=Sing	_	_	_	_
37	appears	appear	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
38	in	in	ADP	IN	_	_	_	_	_
39	Mol	Mol	PROPN	NNP	Number=Sing	_	_	_	_
40	Cell	cell	PROPN	NNP	Number=Sing	_	_	_	_
41	Biol	Biol	PROPN	NNP	Number=Sing	_	_	_	_
42	1996	1996	NUM	CD	NumType=Card	_	_	_	_
43	Feb;16	Feb;16	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
44	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
45	2)	2)	SYM	NFP	_	_	_	_	SpaceAfter=No
46	:735	:735	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
47	]	]	PUNCT	-RRB-	_	_	_	_	SpacesAfter=\s\n

# sent_id = 1526
# text = Initiation binding repressor [corrected] (IBR) is a chicken erythrocyte factor (apparent molecular mass, 70 to 73 kDa) that binds to the sequences spanning the transcription initiation site of the histone h5 gene, repressing its transcription.
1	Initiation	Initiation	NOUN	NN	Number=Sing	_	_	_	_
2	binding	binding	VERB	VBG	VerbForm=Ger	_	_	_	_
3	repressor	repressor	NOUN	NN	Number=Sing	_	_	_	_
4	[	[	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
5	corrected	correct	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	SpaceAfter=No
6	]	]	PUNCT	-RRB-	_	_	_	_	_
7	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
8	IBR	IBR	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
9	)	)	PUNCT	-RRB-	_	_	_	_	_
10	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
11	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
12	chicken	chicken	NOUN	NN	Number=Sing	_	_	_	_
13	erythrocyte	erythrocyte	NOUN	NN	Number=Sing	_	_	_	_
14	factor	factor	NOUN	NN	Number=Sing	_	_	_	_
15	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
16	apparent	apparent	ADJ	JJ	Degree=Pos	_	_	_	_
17	molecular	molecular	ADJ	JJ	Degree=Pos	_	_	_	_
18	mass	mass	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
19	,	,	PUNCT	,	_	_	_	_	_
20	70	70	NUM	CD	NumType=Card	_	_	_	_
21	to	to	ADP	IN	_	_	_	_	_
22	73	73	NUM	CD	NumType=Card	_	_	_	_
23	kDa	kDa	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
24	)	)	PUNCT	-RRB-	_	_	_	_	_
25	that	that	PRON	WDT	PronType=Rel	_	_	_	_
26	binds	bind	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
27	to	to	ADP	IN	_	_	_	_	_
28	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
29	sequences	sequence	NOUN	NNS	Number=Plur	_	_	_	_
30	spanning	spann	VERB	VBG	VerbForm=Ger	_	_	_	_
31	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
32	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
33	initiation	initiation	NOUN	NN	Number=Sing	_	_	_	_
34	site	site	NOUN	NN	Number=Sing	_	_	_	_
35	of	of	ADP	IN	_	_	_	_	_
36	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
37	histone	histone	NOUN	NN	Number=Sing	_	_	_	_
38	h5	h5	NUM	CD	NumType=Card	_	_	_	_
39	gene	gene	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
40	,	,	PUNCT	,	_	_	_	_	_
41	repressing	represse	VERB	VBG	VerbForm=Ger	_	_	_	_
42	its	its	PRON	PRP$	Gender=Neut|Number=Sing|Person=3|Poss=Yes|PronType=Prs	_	_	_	_
43	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
44	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1527
# text = A variety of other cells, including transformed erythroid precursors, do not have IBR but a factor referred to as IBF (68 to 70 kDa) that recognizes the same IBR sites.
1	A	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
2	variety	variety	NOUN	NN	Number=Sing	_	_	_	_
3	of	of	ADP	IN	_	_	_	_	_
4	other	other	ADJ	JJ	Degree=Pos	_	_	_	_
5	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
6	,	,	PUNCT	,	_	_	_	_	_
7	including	include	VERB	VBG	VerbForm=Ger	_	_	_	_
8	transformed	transform	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
9	erythroid	erythroid	NOUN	NN	Number=Sing	_	_	_	_
10	precursors	precursor	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
11	,	,	PUNCT	,	_	_	_	_	_
12	do	do	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
13	not	not	PART	RB	_	_	_	_	_
14	have	have	VERB	VB	VerbForm=Inf	_	_	_	_
15	IBR	IBR	PROPN	NNP	Number=Sing	_	_	_	_
16	but	but	CCONJ	CC	_	_	_	_	_
17	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
18	factor	factor	NOUN	NN	Number=Sing	_	_	_	_
19	referred	refer	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
20	to	to	ADP	IN	_	_	_	_	_
21	as	as	ADP	IN	_	_	_	_	_
22	IBF	IBF	PROPN	NNP	Number=Sing	_	_	_	_
23	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
24	68	68	NUM	CD	NumType=Card	_	_	_	_
25	to	to	ADP	IN	_	_	_	_	_
26	70	70	NUM	CD	NumType=Card	_	_	_	_
27	kDa	kDa	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
28	)	)	PUNCT	-RRB-	_	_	_	_	_
29	that	that	PRON	WDT	PronType=Rel	_	_	_	_
30	recognizes	recognize	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
31	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
32	same	same	ADJ	JJ	Degree=Pos	_	_	_	_
33	IBR	Ibr	NOUN	NN	Number=Sing	_	_	_	_
34	sites	site	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
35	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1528
# text = We have cloned the IBR cDNA and studied the relationship of IBR and IBF.
1	We	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
2	have	have	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
3	cloned	clon	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
4	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
5	IBR	IBR	PROPN	NNP	Number=Sing	_	_	_	_
6	cDNA	cDNA	PROPN	NNP	Number=Sing	_	_	_	_
7	and	and	CCONJ	CC	_	_	_	_	_
8	studied	study	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
9	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
10	relationship	relationship	NOUN	NN	Number=Sing	_	_	_	_
11	of	of	ADP	IN	_	_	_	_	_
12	IBR	IBR	PROPN	NNP	Number=Sing	_	_	_	_
13	and	and	CCONJ	CC	_	_	_	_	_
14	IBF	IBF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
15	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1529
# text = IBR is a 503-amino-acid-long acidic protein which is 99.0% identical to the recently reported human NRF-1/alpha-Pal factor and highly related to the invertebrate transcription factors P3A2 and erected wing gene product (EWG).
1	IBR	Ibr	PROPN	NNP	Number=Sing	_	_	_	_
2	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
3	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
4	503	503	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
5	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
6	amino	amino	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
7	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
8	acid	acid	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
9	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
10	long	long	ADJ	JJ	Degree=Pos	_	_	_	_
11	acidic	acidic	ADJ	JJ	Degree=Pos	_	_	_	_
12	protein	protein	NOUN	NN	Number=Sing	_	_	_	_
13	which	which	PRON	WDT	PronType=Rel	_	_	_	_
14	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
15	99.0	99.0	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
16	%	%	SYM	NN	Number=Sing	_	_	_	_
17	identical	identical	ADJ	JJ	Degree=Pos	_	_	_	_
18	to	to	ADP	IN	_	_	_	_	_
19	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
20	recently	recently	ADV	RB	_	_	_	_	_
21	reported	report	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
22	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
23	NRF	NRF	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
24	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
25	1	1	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
26	/	/	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
27	alpha	alpha	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
28	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
29	Pal	pal	ADJ	JJ	Degree=Pos	_	_	_	_
30	factor	factor	NOUN	NN	Number=Sing	_	_	_	_
31	and	and	CCONJ	CC	_	_	_	_	_
32	highly	highly	ADV	RB	_	_	_	_	_
33	related	related	ADJ	JJ	Degree=Pos	_	_	_	_
34	to	to	ADP	IN	_	_	_	_	_
35	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
36	invertebrate	invertebrate	ADJ	JJ	Degree=Pos	_	_	_	_
37	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
38	factors	factor	NOUN	NNS	Number=Plur	_	_	_	_
39	P3	P3	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
40	A2	A2	NOUN	NN	Number=Sing	_	_	_	_
41	and	and	CCONJ	CC	_	_	_	_	_
42	erected	erect	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
43	wing	w	NOUN	NN	Number=Sing	_	_	_	_
44	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
45	product	product	NOUN	NN	Number=Sing	_	_	_	_
46	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
47	EWG	EWG	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
48	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
49	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1530
# text = We present evidence that IBR and IBF are most likely identical proteins, differing in their degree of glycosylation.
1	We	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
2	present	present	ADJ	JJ	Degree=Pos	_	_	_	_
3	evidence	evidence	NOUN	NN	Number=Sing	_	_	_	_
4	that	that	PRON	WDT	PronType=Rel	_	_	_	_
5	IBR	IBR	PROPN	NNP	Number=Sing	_	_	_	_
6	and	and	CCONJ	CC	_	_	_	_	_
7	IBF	IBF	PROPN	NNP	Number=Sing	_	_	_	_
8	are	be	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
9	most	most	ADV	RBS	_	_	_	_	_
10	likely	likely	ADJ	JJ	Degree=Pos	_	_	_	_
11	identical	identical	ADJ	JJ	Degree=Pos	_	_	_	_
12	proteins	protein	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
13	,	,	PUNCT	,	_	_	_	_	_
14	differing	differ	VERB	VBG	VerbForm=Ger	_	_	_	_
15	in	in	ADP	IN	_	_	_	_	_
16	their	they	PRON	PRP$	Number=Plur|Person=3|Poss=Yes|PronType=Prs	_	_	_	_
17	degree	degree	NOUN	NN	Number=Sing	_	_	_	_
18	of	of	ADP	IN	_	_	_	_	_
19	glycosylation	glycosylation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
20	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1531
# text = We have analyzed several molecular aspects of IBR/F and shown that the factor associates as stable homodimers and that the dimer is the relevant DNA-binding species.
1	We	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
2	have	have	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
3	analyzed	analyze	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
4	several	several	ADJ	JJ	Degree=Pos	_	_	_	_
5	molecular	molecular	ADJ	JJ	Degree=Pos	_	_	_	_
6	aspects	aspect	NOUN	NNS	Number=Plur	_	_	_	_
7	of	of	ADP	IN	_	_	_	_	_
8	IBR/	IBR/	ADP	IN	Abbr=Yes	_	_	_	SpaceAfter=No
9	F	F	PROPN	NNP	Number=Sing	_	_	_	_
10	and	and	CCONJ	CC	_	_	_	_	_
11	shown	show	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
12	that	that	SCONJ	IN	_	_	_	_	_
13	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
14	factor	factor	NOUN	NN	Number=Sing	_	_	_	_
15	associates	associate	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
16	as	as	ADP	IN	_	_	_	_	_
17	stable	stable	ADJ	JJ	Degree=Pos	_	_	_	_
18	homodimers	homodimer	NOUN	NNS	Number=Plur	_	_	_	_
19	and	and	CCONJ	CC	_	_	_	_	_
20	that	that	SCONJ	IN	_	_	_	_	_
21	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
22	dimer	dimer	NOUN	NN	Number=Sing	_	_	_	_
23	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
24	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
25	relevant	relevant	ADJ	JJ	Degree=Pos	_	_	_	_
26	DNA	dna	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
27	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
28	binding	binding	VERB	VBG	VerbForm=Ger	_	_	_	_
29	species	species	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
30	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1532
# text = The evolutionarily conserved N-terminal half of IBR/F harbors the DNA-binding/dimerization domain (outer limits, 127 to 283), one or several casein kinase II sites (37 to 67), and a bipartite nuclear localization signal (89 to 106) which appears to be necessary for nuclear targeting.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	evolutionarily	evolutionarily	ADV	RB	Degree=Pos	_	_	_	_
3	conserved	conserve	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
4	N-	N-	SYM	SYM	_	_	_	_	SpaceAfter=No
5	terminal	terminal	ADJ	JJ	Degree=Pos	_	_	_	_
6	half	half	NOUN	NN	Number=Sing	_	_	_	_
7	of	of	ADP	IN	_	_	_	_	_
8	IBR/	Ibr/	ADP	IN	Abbr=Yes	_	_	_	SpaceAfter=No
9	F	F	PROPN	NNP	Number=Sing	_	_	_	_
10	harbors	harbor	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
11	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
12	DNA	dna	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
13	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
14	binding	binding	VERB	VBG	VerbForm=Ger	_	_	_	SpaceAfter=No
15	/	/	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
16	dimerization	dimerization	NOUN	NN	Number=Sing	_	_	_	_
17	domain	domain	NOUN	NN	Number=Sing	_	_	_	_
18	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
19	outer	outer	ADJ	JJ	Degree=Pos	_	_	_	_
20	limits	limit	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
21	,	,	PUNCT	,	_	_	_	_	_
22	127	127	NUM	CD	NumType=Card	_	_	_	_
23	to	to	ADP	IN	_	_	_	_	_
24	283	283	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
25	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
26	,	,	PUNCT	,	_	_	_	_	_
27	one	one	NUM	CD	NumType=Card	_	_	_	_
28	or	or	CCONJ	CC	_	_	_	_	_
29	several	several	ADJ	JJ	Degree=Pos	_	_	_	_
30	casein	casein	NOUN	NN	Number=Sing	_	_	_	_
31	kinase	kinase	NOUN	NN	Number=Sing	_	_	_	_
32	II	ii	NUM	CD	NumType=Card	_	_	_	_
33	sites	site	NOUN	NNS	Number=Plur	_	_	_	_
34	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
35	37	37	NUM	CD	NumType=Card	_	_	_	_
36	to	to	ADP	IN	_	_	_	_	_
37	67	67	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
38	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
39	,	,	PUNCT	,	_	_	_	_	_
40	and	and	CCONJ	CC	_	_	_	_	_
41	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
42	bipartite	bipartite	ADJ	JJ	Degree=Pos	_	_	_	_
43	nuclear	nuclear	ADJ	JJ	Degree=Pos	_	_	_	_
44	localization	localization	NOUN	NN	Number=Sing	_	_	_	_
45	signal	signal	NOUN	NN	Number=Sing	_	_	_	_
46	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
47	89	89	NUM	CD	NumType=Card	_	_	_	_
48	to	to	ADP	IN	_	_	_	_	_
49	106	106	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
50	)	)	PUNCT	-RRB-	_	_	_	_	_
51	which	which	PRON	WDT	PronType=Rel	_	_	_	_
52	appears	appear	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
53	to	to	PART	TO	_	_	_	_	_
54	be	be	AUX	VB	VerbForm=Inf	_	_	_	_
55	necessary	necessary	ADJ	JJ	Degree=Pos	_	_	_	_
56	for	for	ADP	IN	_	_	_	_	_
57	nuclear	nuclear	ADJ	JJ	Degree=Pos	_	_	_	_
58	targeting	targeting	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
59	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1533
# text = Binding site selection revealed that the alternating RCGCRYGCGY consensus constitutes high-affinity IBR/F binding sites and that the direct-repeat palindrome TGCGCATGCGCA is the optimal site.
1	Binding	bind	VERB	VBG	VerbForm=Ger	_	_	_	_
2	site	site	NOUN	NN	Number=Sing	_	_	_	_
3	selection	selection	NOUN	NN	Number=Sing	_	_	_	_
4	revealed	reveal	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
5	that	that	SCONJ	IN	_	_	_	_	_
6	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
7	alternating	alternate	VERB	VBG	VerbForm=Ger	_	_	_	_
8	RCGCRYGCGY	Rcgcrygcgy	NOUN	NN	Number=Sing	_	_	_	_
9	consensus	consensus	NOUN	NN	Number=Sing	_	_	_	_
10	constitutes	constitute	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
11	high	high	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
12	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
13	affinity	affinity	NOUN	NN	Number=Sing	_	_	_	_
14	IBR/	IBR/	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
15	F	f	SCONJ	IN	_	_	_	_	_
16	binding	binding	VERB	VBG	VerbForm=Ger	_	_	_	_
17	sites	site	NOUN	NNS	Number=Plur	_	_	_	_
18	and	and	CCONJ	CC	_	_	_	_	_
19	that	that	SCONJ	IN	_	_	_	_	_
20	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
21	direct	direct	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
22	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
23	repeat	repeat	ADJ	JJ	Degree=Pos	_	_	_	_
24	palindrome	palindrome	NOUN	NN	Number=Sing	_	_	_	_
25	TGCGCATGCGCA	TGCGCATGCGCa	NOUN	NN	Number=Sing	_	_	_	_
26	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
27	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
28	optimal	optimal	ADJ	JJ	Degree=Pos	_	_	_	_
29	site	site	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
30	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1534
# text = A survey of genes potentially regulated by this family of factors primarily revealed genes involved in growth-related metabolism.
1	A	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
2	survey	survey	NOUN	NN	Number=Sing	_	_	_	_
3	of	of	ADP	IN	_	_	_	_	_
4	genes	gene	NOUN	NNS	Number=Plur	_	_	_	_
5	potentially	potentially	ADV	RB	_	_	_	_	_
6	regulated	regulate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
7	by	by	ADP	IN	_	_	_	_	_
8	this	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
9	family	family	NOUN	NN	Number=Sing	_	_	_	_
10	of	of	ADP	IN	_	_	_	_	_
11	factors	factor	NOUN	NNS	Number=Plur	_	_	_	_
12	primarily	primarily	ADV	RB	_	_	_	_	_
13	revealed	reveale	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
14	genes	gene	NOUN	NNS	Number=Plur	_	_	_	_
15	involved	involve	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
16	in	in	ADP	IN	_	_	_	_	_
17	growth	growth	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
18	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
19	related	related	ADJ	JJ	Degree=Pos	_	_	_	_
20	metabolism	metabolism	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
21	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 1535
# text = Document 003002564 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	003002	003002	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
3	564	564	NUM	CD	NumType=Card	_	_	_	_
4	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
5	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 1536
# text = Apoptosis signaling pathways in normal T cells: differential activity of Bcl-2 and IL-1beta-converting enzyme family protease inhibitors on glucocorticoid- and Fas-mediated cytotoxicity.
1	Apoptosis	Apoptosis	PROPN	NNP	Number=Sing	_	_	_	_
2	signaling	signal	VERB	VBG	VerbForm=Ger	_	_	_	_
3	pathways	pathway	NOUN	NNS	Number=Plur	_	_	_	_
4	in	in	ADP	IN	_	_	_	_	_
5	normal	normal	ADJ	JJ	Degree=Pos	_	_	_	_
6	T	t	PROPN	NNP	Number=Sing	_	_	_	_
7	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
8	:	:	PUNCT	:	_	_	_	_	_
9	differential	differential	ADJ	JJ	Degree=Pos	_	_	_	_
10	activity	activity	NOUN	NN	Number=Sing	_	_	_	_
11	of	of	ADP	IN	_	_	_	_	_
12	Bcl	Bcl	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
13	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
14	2	2	NUM	CD	NumType=Card	_	_	_	_
15	and	and	CCONJ	CC	_	_	_	_	_
16	IL	Il	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
17	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
18	1	1	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
19	beta	beta	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
20	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
21	converting	convert	VERB	VBG	VerbForm=Ger	_	_	_	_
22	enzyme	enzyme	ADJ	JJ	Degree=Pos	_	_	_	_
23	family	family	NOUN	NN	Number=Sing	_	_	_	_
24	protease	protease	NOUN	NN	Number=Sing	_	_	_	_
25	inhibitors	inhibitor	NOUN	NNS	Number=Plur	_	_	_	_
26	on	on	ADP	IN	_	_	_	_	_
27	glucocorticoid	glucocorticoid	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
28	-	-	PUNCT	,	_	_	_	_	_
29	and	and	CCONJ	CC	_	_	_	_	_
30	Fas-	Fas-	SYM	NFP	_	_	_	_	SpaceAfter=No
31	mediated	mediate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
32	cytotoxicity	cytotoxicity	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
33	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 1537
# text = Fas-mediated apoptosis plays an important role in regulating the immune response in peripheral T cells.
1	Fas-	Fas-	SYM	NFP	_	_	_	_	SpaceAfter=No
2	mediated	mediate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
3	apoptosis	apoptosis	NOUN	NN	Number=Sing	_	_	_	_
4	plays	play	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
5	an	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
6	important	important	ADJ	JJ	Degree=Pos	_	_	_	_
7	role	role	NOUN	NN	Number=Sing	_	_	_	_
8	in	in	SCONJ	IN	_	_	_	_	_
9	regulating	regulate	VERB	VBG	VerbForm=Ger	_	_	_	_
10	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
11	immune	immune	ADJ	JJ	Degree=Pos	_	_	_	_
12	response	response	NOUN	NN	Number=Sing	_	_	_	_
13	in	in	ADP	IN	_	_	_	_	_
14	peripheral	peripheral	ADJ	JJ	Degree=Pos	_	_	_	_
15	T	t	PROPN	NNP	Number=Sing	_	_	_	_
16	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
17	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1538
# text = Restimulation of T cell blasts up-regulates Fas and Fas ligand expression, with subsequent interaction leading to cell death.
1	Restimulation	Restimulation	NOUN	NN	Number=Sing	_	_	_	_
2	of	of	ADP	IN	_	_	_	_	_
3	T	t	PROPN	NNP	Number=Sing	_	_	_	_
4	cell	cell	PROPN	NNP	Number=Sing	_	_	_	_
5	blasts	blast	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
6	up	up	ADP	RP	_	_	_	_	SpaceAfter=No
7	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
8	regulates	regulate	NOUN	NNS	Number=Plur	_	_	_	_
9	Fas	Fa	NOUN	NNS	Number=Plur	_	_	_	_
10	and	and	CCONJ	CC	_	_	_	_	_
11	Fas	Fa	NOUN	NNS	Number=Plur	_	_	_	_
12	ligand	ligand	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
13	expression	expression	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
14	,	,	PUNCT	,	_	_	_	_	_
15	with	with	ADP	IN	_	_	_	_	_
16	subsequent	subsequent	ADJ	JJ	Degree=Pos	_	_	_	_
17	interaction	interaction	NOUN	NN	Number=Sing	_	_	_	_
18	leading	lead	VERB	VBG	VerbForm=Ger	_	_	_	_
19	to	to	PART	TO	_	_	_	_	_
20	cell	cell	VERB	VB	VerbForm=Inf	_	_	_	_
21	death	death	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
22	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1539
# text = Overexpression of Bcl-2 in tumor cells blocks apoptosis induced by many stimuli, but inhibition of Fas-mediated killing has not been consistently observed.
1	Overexpression	Overexpression	NOUN	NN	Number=Sing	_	_	_	_
2	of	of	ADP	IN	_	_	_	_	_
3	Bcl	Bcl	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
4	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
5	2	2	NUM	CD	NumType=Card	_	_	_	_
6	in	in	ADP	IN	_	_	_	_	_
7	tumor	tumor	ADJ	JJ	Degree=Pos	_	_	_	_
8	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
9	blocks	block	NOUN	NNS	Number=Plur	_	_	_	_
10	apoptosis	apoptosis	NOUN	NN	Number=Sing	_	_	_	_
11	induced	induce	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
12	by	by	ADP	IN	_	_	_	_	_
13	many	many	ADJ	JJ	Degree=Pos	_	_	_	_
14	stimuli	stimuli	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
15	,	,	PUNCT	,	_	_	_	_	_
16	but	but	CCONJ	CC	_	_	_	_	_
17	inhibition	inhibition	NOUN	NN	Number=Sing	_	_	_	_
18	of	of	ADP	IN	_	_	_	_	_
19	Fas-	Fas-	SYM	NFP	_	_	_	_	SpaceAfter=No
20	mediated	mediate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
21	killing	killing	NOUN	NN	Number=Sing	_	_	_	_
22	has	have	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
23	not	not	PART	RB	_	_	_	_	_
24	been	be	AUX	VBN	Tense=Past|VerbForm=Part	_	_	_	_
25	consistently	consistently	ADV	RB	_	_	_	_	_
26	observed	observe	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	SpaceAfter=No
27	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1540
# text = To examine the behavior of Bcl-2 in normal cells, T cell blasts were transiently transfected with Bcl-2 and related gene products to determine the effect on apoptotic signaling.
1	To	to	PART	TO	_	_	_	_	_
2	examine	examine	VERB	VB	VerbForm=Inf	_	_	_	_
3	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
4	behavior	behavior	NOUN	NN	Number=Sing	_	_	_	_
5	of	of	ADP	IN	_	_	_	_	_
6	Bcl	Bcl	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
7	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
8	2	2	NUM	CD	NumType=Card	_	_	_	_
9	in	in	ADP	IN	_	_	_	_	_
10	normal	normal	ADJ	JJ	Degree=Pos	_	_	_	_
11	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
12	,	,	PUNCT	,	_	_	_	_	_
13	T	t	PROPN	NNP	Number=Sing	_	_	_	_
14	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
15	blasts	blast	NOUN	NNS	Number=Plur	_	_	_	_
16	were	be	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
17	transiently	transiently	ADV	RB	_	_	_	_	_
18	transfected	transfect	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
19	with	with	ADP	IN	_	_	_	_	_
20	Bcl	Bcl	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
21	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
22	2	2	NUM	CD	NumType=Card	_	_	_	_
23	and	and	CCONJ	CC	_	_	_	_	_
24	related	relate	ADJ	JJ	Degree=Pos	_	_	_	_
25	gene	gene	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
26	products	product	NOUN	NNS	Number=Plur	_	_	_	_
27	to	to	PART	TO	_	_	_	_	_
28	determine	determine	VERB	VB	VerbForm=Inf	_	_	_	_
29	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
30	effect	effect	NOUN	NN	Number=Sing	_	_	_	_
31	on	on	ADP	IN	_	_	_	_	_
32	apoptotic	apoptotic	ADJ	JJ	Degree=Pos	_	_	_	_
33	signaling	signaling	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
34	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1541
# text = Transient overexpression of Bcl-2 in mouse and human T cell blasts did not block Fas-mediated apoptosis, whereas etoposide- and glucocorticoid-induced cytotoxicity was potently inhibited.
1	Transient	Transient	ADJ	JJ	Degree=Pos	_	_	_	_
2	overexpression	overexpression	NOUN	NN	Number=Sing	_	_	_	_
3	of	of	ADP	IN	_	_	_	_	_
4	Bcl	Bcl	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
5	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
6	2	2	NUM	CD	NumType=Card	_	_	_	_
7	in	in	ADP	IN	_	_	_	_	_
8	mouse	mouse	NOUN	NN	Number=Sing	_	_	_	_
9	and	and	CCONJ	CC	_	_	_	_	_
10	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
11	T	T	PROPN	NNP	Number=Sing	_	_	_	_
12	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
13	blasts	blast	NOUN	NNS	Number=Plur	_	_	_	_
14	did	do	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
15	not	not	PART	RB	_	_	_	_	_
16	block	block	VERB	VB	VerbForm=Inf	_	_	_	_
17	Fas-	Fas-	PUNCT	:	_	_	_	_	SpaceAfter=No
18	mediated	mediate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
19	apoptosis	apoptosis	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
20	,	,	PUNCT	,	_	_	_	_	_
21	whereas	wherea	ADV	RB	_	_	_	_	_
22	etoposide	etoposide	ADV	RB	_	_	_	_	SpaceAfter=No
23	-	-	PUNCT	,	_	_	_	_	_
24	and	and	CCONJ	CC	_	_	_	_	_
25	glucocorticoid	glucocorticoid	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
26	-induced	-induced	ADJ	JJ	Degree=Pos	_	_	_	_
27	cytotoxicity	cytotoxicity	NOUN	NN	Number=Sing	_	_	_	_
28	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
29	potently	potently	ADV	RB	_	_	_	_	_
30	inhibited	inhibit	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	SpaceAfter=No
31	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1542
# text = Expression of Bcl-xL and adenovirus E1B 19K did not interfere with anti-Fas killing.
1	Expression	expression	NOUN	NN	Number=Sing	_	_	_	_
2	of	of	ADP	IN	_	_	_	_	_
3	Bcl	Bcl	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
4	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
5	xL	xL	PROPN	NNP	Number=Sing	_	_	_	_
6	and	and	CCONJ	CC	_	_	_	_	_
7	adenovirus	adenovirus	PROPN	NNP	Number=Sing	_	_	_	_
8	E1B	E1B	PROPN	NNP	Number=Sing	_	_	_	_
9	19	19	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
10	K	k	NUM	CD	NumType=Card	_	_	_	_
11	did	do	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
12	not	not	PART	RB	_	_	_	_	_
13	interfere	interfere	VERB	VB	VerbForm=Inf	_	_	_	_
14	with	with	ADP	IN	_	_	_	_	_
15	anti	anti	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
16	-Fas	-Fas	SCONJ	IN	_	_	_	_	_
17	killing	kill	VERB	VBG	VerbForm=Ger	_	_	_	SpaceAfter=No
18	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1543
# text = In contrast, interleukin-1beta-converting enzyme family protease inhibitors Ac-DEVD-CHO and CrmA blocked Fas-mediated apoptosis.
1	In	in	ADP	IN	_	_	_	_	_
2	contrast	contrast	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
3	,	,	PUNCT	,	_	_	_	_	_
4	interleukin	interleukin	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
5	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
6	1	1	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
7	beta	beta	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
8	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
9	converting	converte	VERB	VBG	VerbForm=Ger	_	_	_	_
10	enzyme	enzyme	ADJ	JJ	Degree=Pos	_	_	_	_
11	family	family	NOUN	NN	Number=Sing	_	_	_	_
12	protease	protease	NOUN	NN	Number=Sing	_	_	_	_
13	inhibitors	inhibitor	NOUN	NNS	Number=Plur	_	_	_	_
14	Ac-	Ac-	PUNCT	,	_	_	_	_	SpaceAfter=No
15	DEVD	DEVD	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
16	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
17	CHO	Cho	PROPN	NNP	Number=Sing	_	_	_	_
18	and	and	CCONJ	CC	_	_	_	_	_
19	CrmA	CrmA	PROPN	NNP	Number=Sing	_	_	_	_
20	blocked	block	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
21	Fas	Fas	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
22	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
23	mediated	mediate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
24	apoptosis	apoptosis	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
25	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1544
# text = These results suggest that peripheral T cells use distinct apoptosis signaling pathways with differential sensitivity to Bcl-2 and interleukin-1beta-converting enzyme family protease inhibitors.
1	These	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
2	results	result	NOUN	NNS	Number=Plur	_	_	_	_
3	suggest	suggest	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
4	that	that	SCONJ	IN	_	_	_	_	_
5	peripheral	peripheral	ADJ	JJ	Degree=Pos	_	_	_	_
6	T	t	PROPN	NNP	Number=Sing	_	_	_	_
7	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
8	use	use	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
9	distinct	distinct	ADJ	JJ	Degree=Pos	_	_	_	_
10	apoptosis	apoptosis	NOUN	NN	Number=Sing	_	_	_	_
11	signaling	signale	VERB	VBG	VerbForm=Ger	_	_	_	_
12	pathways	pathway	NOUN	NNS	Number=Plur	_	_	_	_
13	with	with	ADP	IN	_	_	_	_	_
14	differential	differential	ADJ	JJ	Degree=Pos	_	_	_	_
15	sensitivity	sensitivity	NOUN	NN	Number=Sing	_	_	_	_
16	to	to	ADP	IN	_	_	_	_	_
17	Bcl	Bcl	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
18	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
19	2	2	NUM	CD	NumType=Card	_	_	_	_
20	and	and	CCONJ	CC	_	_	_	_	_
21	interleukin	interleukin	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
22	-1	-1	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
23	beta	beta	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
24	-	-	SYM	SYM	_	_	_	_	SpaceAfter=No
25	converting	convert	VERB	VBG	VerbForm=Ger	_	_	_	_
26	enzyme	enzyme	ADJ	JJ	Degree=Pos	_	_	_	_
27	family	family	NOUN	NN	Number=Sing	_	_	_	_
28	protease	protease	NOUN	NN	Number=Sing	_	_	_	_
29	inhibitors	inhibitor	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
30	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1545
# text = Since T cells normally express Bcl-2 and Bcl-xL following activation, their inability to block Fas-mediated apoptosis may allow for the elimination of self-reactive cells and the appropriate regulation of immune responses.
1	Since	since	SCONJ	IN	_	_	_	_	_
2	T	t	PROPN	NNP	Number=Sing	_	_	_	_
3	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
4	normally	normally	ADV	RB	_	_	_	_	_
5	express	express	ADJ	JJ	Degree=Pos	_	_	_	_
6	Bcl	Bcl	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
7	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
8	2	2	NUM	CD	NumType=Card	_	_	_	_
9	and	and	CCONJ	CC	_	_	_	_	_
10	Bcl	Bcl	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
11	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
12	xL	xL	PROPN	NNP	Number=Sing	_	_	_	_
13	following	follow	VERB	VBG	VerbForm=Ger	_	_	_	_
14	activation	activation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
15	,	,	PUNCT	,	_	_	_	_	_
16	their	they	PRON	PRP$	Number=Plur|Person=3|Poss=Yes|PronType=Prs	_	_	_	_
17	inability	inability	NOUN	NN	Number=Sing	_	_	_	_
18	to	to	PART	TO	_	_	_	_	_
19	block	block	VERB	VB	VerbForm=Inf	_	_	_	_
20	Fas-	Fas-	PUNCT	:	_	_	_	_	SpaceAfter=No
21	mediated	mediate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
22	apoptosis	apoptosis	PRON	PRP$	Gender=Masc|Number=Sing|Person=3|Poss=Yes|PronType=Prs	_	_	_	_
23	may	may	AUX	MD	VerbForm=Fin	_	_	_	_
24	allow	allow	VERB	VB	VerbForm=Inf	_	_	_	_
25	for	for	ADP	IN	_	_	_	_	_
26	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
27	elimination	elimination	NOUN	NN	Number=Sing	_	_	_	_
28	of	of	ADP	IN	_	_	_	_	_
29	self	self	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
30	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
31	reactive	reactive	ADJ	JJ	Degree=Pos	_	_	_	_
32	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
33	and	and	CCONJ	CC	_	_	_	_	_
34	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
35	appropriate	appropriate	ADJ	JJ	Degree=Pos	_	_	_	_
36	regulation	regulation	NOUN	NN	Number=Sing	_	_	_	_
37	of	of	ADP	IN	_	_	_	_	_
38	immune	immune	ADJ	JJ	Degree=Pos	_	_	_	_
39	responses	respons	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
40	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 1546
# text = Document 003002565 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	003002565	003002565	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 1547
# text = Induction of monocytic differentiation and NF-kappa B-like activities by human immunodeficiency virus 1 infection of myelomonoblastic cells.
1	Induction	Induction	NOUN	NN	Number=Sing	_	_	_	_
2	of	of	ADP	IN	_	_	_	_	_
3	monocytic	monocytic	ADJ	JJ	Degree=Pos	_	_	_	_
4	differentiation	differentiation	NOUN	NN	Number=Sing	_	_	_	_
5	and	and	CCONJ	CC	_	_	_	_	_
6	NF	Nf	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
7	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
8	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_
9	B	b	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
10	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
11	like	like	ADJ	JJ	Degree=Pos	_	_	_	_
12	activities	activity	NOUN	NNS	Number=Plur	_	_	_	_
13	by	by	ADP	IN	_	_	_	_	_
14	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
15	immunodeficiency	immunodeficiency	NOUN	NN	Number=Sing	_	_	_	_
16	virus	virus	NOUN	NN	Number=Sing	_	_	_	_
17	1	1	NUM	CD	NumType=Card	_	_	_	_
18	infection	infection	NOUN	NN	Number=Sing	_	_	_	_
19	of	of	ADP	IN	_	_	_	_	_
20	myelomonoblastic	myelomonoblastic	ADJ	JJ	Degree=Pos	_	_	_	_
21	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
22	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 1548
# text = The effects of human immunodeficiency virus 1 (HIV-1) infection on cellular differentiation and NF-kappa B DNA binding activity have been investigated in a new model of myeloid differentiation.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	effects	effect	NOUN	NNS	Number=Plur	_	_	_	_
3	of	of	ADP	IN	_	_	_	_	_
4	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
5	immunodeficiency	immunodeficiency	NOUN	NN	Number=Sing	_	_	_	_
6	virus	virus	NOUN	NN	Number=Sing	_	_	_	_
7	1	1	NUM	CD	NumType=Card	_	_	_	_
8	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
9	HIV	Hiv	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
10	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
11	1	1	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
12	)	)	PUNCT	-RRB-	_	_	_	_	_
13	infection	infection	NOUN	NN	Number=Sing	_	_	_	_
14	on	on	ADP	IN	_	_	_	_	_
15	cellular	cellular	ADJ	JJ	Degree=Pos	_	_	_	_
16	differentiation	differentiation	NOUN	NN	Number=Sing	_	_	_	_
17	and	and	CCONJ	CC	_	_	_	_	_
18	NF	Nf	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
19	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
20	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_
21	B	b	NOUN	NN	Number=Sing	_	_	_	_
22	DNA	dna	NOUN	NN	Number=Sing	_	_	_	_
23	binding	binding	VERB	VBG	VerbForm=Ger	_	_	_	_
24	activity	activity	NOUN	NN	Number=Sing	_	_	_	_
25	have	have	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
26	been	be	AUX	VBN	Tense=Past|VerbForm=Part	_	_	_	_
27	investigated	investigate	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
28	in	in	ADP	IN	_	_	_	_	_
29	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
30	new	new	ADJ	JJ	Degree=Pos	_	_	_	_
31	model	model	NOUN	NN	Number=Sing	_	_	_	_
32	of	of	ADP	IN	_	_	_	_	_
33	myeloid	myeloid	ADJ	JJ	Degree=Pos	_	_	_	_
34	differentiation	differentiation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
35	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1549
# text = PLB-985 cells represent a bipotential myelomonoblastic cell population capable of either granulocytic or monocytic differentiation after induction with appropriate inducers.
1	PLB	Plb	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
2	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
3	985	985	NUM	CD	NumType=Card	_	_	_	_
4	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
5	represent	represent	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
6	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
7	bipotential	bipotential	ADJ	JJ	Degree=Pos	_	_	_	_
8	myelomonoblastic	myelomonoblastic	ADJ	JJ	Degree=Pos	_	_	_	_
9	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
10	population	population	NOUN	NN	Number=Sing	_	_	_	_
11	capable	capable	ADJ	JJ	Degree=Pos	_	_	_	_
12	of	of	ADP	IN	_	_	_	_	_
13	either	either	CCONJ	CC	_	_	_	_	_
14	granulocytic	granulocytic	ADJ	JJ	Degree=Pos	_	_	_	_
15	or	or	CCONJ	CC	_	_	_	_	_
16	monocytic	monocytic	ADJ	JJ	Degree=Pos	_	_	_	_
17	differentiation	differentiation	NOUN	NN	Number=Sing	_	_	_	_
18	after	after	ADP	IN	_	_	_	_	_
19	induction	induction	NOUN	NN	Number=Sing	_	_	_	_
20	with	with	ADP	IN	_	_	_	_	_
21	appropriate	appropriate	ADJ	JJ	Degree=Pos	_	_	_	_
22	inducers	inducer	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
23	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1550
# text = By virtue of the presence of CD4 on the cell surface, PLB-985 cells were chronically infected with HIV-1 strain IIIB.
1	By	by	ADP	IN	_	_	_	_	_
2	virtue	virtue	NOUN	NN	Number=Sing	_	_	_	_
3	of	of	ADP	IN	_	_	_	_	_
4	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
5	presence	presence	NOUN	NN	Number=Sing	_	_	_	_
6	of	of	ADP	IN	_	_	_	_	_
7	CD4	CD4	NUM	CD	NumType=Card	_	_	_	_
8	on	on	ADP	IN	_	_	_	_	_
9	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
10	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
11	surface	surface	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
12	,	,	PUNCT	,	_	_	_	_	_
13	PLB	Plb	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
14	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
15	985	985	NUM	CD	NumType=Card	_	_	_	_
16	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
17	were	be	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
18	chronically	chronically	ADV	RB	_	_	_	_	_
19	infected	infect	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
20	with	with	ADP	IN	_	_	_	_	_
21	HIV	HIV	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
22	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
23	1	1	NUM	CD	NumType=Card	_	_	_	_
24	strain	strain	NOUN	NN	Number=Sing	_	_	_	_
25	IIIB	Iiib	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
26	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1551
# text = PLB-IIIB cells clearly possessed a more monocytic phenotype than the parental myeloblasts, as determined by differential staining, increased expression of the myeloid-specific surface markers, and transcription of the c-fms proto-oncogene.
1	PLB	Plb	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
2	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
3	IIIB	Iiib	NOUN	NN	Number=Sing	_	_	_	_
4	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
5	clearly	clearly	ADV	RB	_	_	_	_	_
6	possessed	possess	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
7	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
8	more	more	ADV	RBR	_	_	_	_	_
9	monocytic	monocytic	ADJ	JJ	Degree=Pos	_	_	_	_
10	phenotype	phenotype	NOUN	NN	Number=Sing	_	_	_	_
11	than	than	ADP	IN	_	_	_	_	_
12	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
13	parental	parental	ADJ	JJ	Degree=Pos	_	_	_	_
14	myeloblasts	myeloblast	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
15	,	,	PUNCT	,	_	_	_	_	_
16	as	as	SCONJ	IN	_	_	_	_	_
17	determined	determine	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
18	by	by	ADP	IN	_	_	_	_	_
19	differential	differential	ADJ	JJ	Degree=Pos	_	_	_	_
20	staining	staining	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
21	,	,	PUNCT	,	_	_	_	_	_
22	increased	increase	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
23	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
24	of	of	ADP	IN	_	_	_	_	_
25	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
26	myeloid	myeloid	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
27	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
28	specific	specific	ADJ	JJ	Degree=Pos	_	_	_	_
29	surface	surface	NOUN	NN	Number=Sing	_	_	_	_
30	markers	marker	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
31	,	,	PUNCT	,	_	_	_	_	_
32	and	and	CCONJ	CC	_	_	_	_	_
33	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
34	of	of	ADP	IN	_	_	_	_	_
35	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
36	c-	c-	SYM	NFP	_	_	_	_	SpaceAfter=No
37	fms	fm	NOUN	NNS	Number=Plur	_	_	_	_
38	proto	proto	PART	TO	_	_	_	_	SpaceAfter=No
39	-oncogene	-oncogene	VERB	VB	VerbForm=Inf	_	_	_	SpaceAfter=No
40	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1552
# text = NF-kappa B binding activity was inducible by tumor necrosis factor and phorbol myristate acetate in PLB-985.
1	NF	Nf	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
2	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
3	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_
4	B	b	NOUN	NN	Number=Sing	_	_	_	_
5	binding	binde	VERB	VBG	VerbForm=Ger	_	_	_	_
6	activity	activity	NOUN	NN	Number=Sing	_	_	_	_
7	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
8	inducible	inducible	ADJ	JJ	Degree=Pos	_	_	_	_
9	by	by	ADP	IN	_	_	_	_	_
10	tumor	tumor	NOUN	NN	Number=Sing	_	_	_	_
11	necrosis	necrosis	NOUN	NN	Number=Sing	_	_	_	_
12	factor	factor	NOUN	NN	Number=Sing	_	_	_	_
13	and	and	CCONJ	CC	_	_	_	_	_
14	phorbol	phorbol	NOUN	NN	Number=Sing	_	_	_	_
15	myristate	myristate	NOUN	NN	Number=Sing	_	_	_	_
16	acetate	acetate	NOUN	NN	Number=Sing	_	_	_	_
17	in	in	ADP	IN	_	_	_	_	_
18	PLB	PLB	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
19	-	-	SYM	SYM	_	_	_	_	SpaceAfter=No
20	985	985	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
21	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1553
# text = However, in PLB-IIIB cells, constitutive expression of a novel NF-kappa B complex was detected, composed of proteins ranging between 70 and 110 kD.
1	However	however	ADV	RB	_	_	_	_	SpaceAfter=No
2	,	,	PUNCT	,	_	_	_	_	_
3	in	in	ADP	IN	_	_	_	_	_
4	PLB	PLB	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
5	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
6	IIIB	IIIB	PROPN	NNP	Number=Sing	_	_	_	_
7	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
8	,	,	PUNCT	,	_	_	_	_	_
9	constitutive	constitutive	ADJ	JJ	Degree=Pos	_	_	_	_
10	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
11	of	of	ADP	IN	_	_	_	_	_
12	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
13	novel	novel	NOUN	NN	Number=Sing	_	_	_	_
14	NF	Nf	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
15	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
16	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_
17	B	b	NOUN	NN	Number=Sing	_	_	_	_
18	complex	complex	NOUN	NN	Number=Sing	_	_	_	_
19	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
20	detected	detect	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	SpaceAfter=No
21	,	,	PUNCT	,	_	_	_	_	_
22	composed	compose	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
23	of	of	ADP	IN	_	_	_	_	_
24	proteins	protein	NOUN	NNS	Number=Plur	_	_	_	_
25	ranging	range	VERB	VBG	VerbForm=Ger	_	_	_	_
26	between	between	ADP	IN	_	_	_	_	_
27	70	70	NUM	CD	NumType=Card	_	_	_	_
28	and	and	CCONJ	CC	_	_	_	_	_
29	110	110	NUM	CD	NumType=Card	_	_	_	_
30	kD	kD	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
31	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1554
# text = These proteins interacted specifically with the symmetric NF-kappa B site from the interferon beta (IFN-beta) promoter.
1	These	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
2	proteins	protein	NOUN	NNS	Number=Plur	_	_	_	_
3	interacted	interact	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
4	specifically	specifically	ADV	RB	_	_	_	_	_
5	with	with	ADP	IN	_	_	_	_	_
6	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
7	symmetric	symmetric	ADJ	JJ	Degree=Pos	_	_	_	_
8	NF	Nf	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
9	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
10	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_
11	B	b	NOUN	NN	Number=Sing	_	_	_	_
12	site	site	NOUN	NN	Number=Sing	_	_	_	_
13	from	from	ADP	IN	_	_	_	_	_
14	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
15	interferon	interferon	NOUN	NN	Number=Sing	_	_	_	_
16	beta	beta	NOUN	NN	Number=Sing	_	_	_	_
17	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
18	IFN	Ifn	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
19	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
20	beta	beta	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
21	)	)	PUNCT	-RRB-	_	_	_	_	_
22	promoter	promoter	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
23	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1555
# text = Mutations affecting the 5' guanine residues of the kappa B site were unable to compete for these NF-kappa B-related proteins.
1	Mutations	Mutation	NOUN	NNS	Number=Plur	_	_	_	_
2	affecting	affecte	VERB	VBG	VerbForm=Ger	_	_	_	_
3	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
4	5	5	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
5	'	'	PUNCT	``	_	_	_	_	_
6	guanine	guanine	NOUN	NN	Number=Sing	_	_	_	_
7	residues	residue	NOUN	NNS	Number=Plur	_	_	_	_
8	of	of	ADP	IN	_	_	_	_	_
9	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
10	kappa	kappa	PROPN	NNP	Number=Sing	_	_	_	_
11	B	b	PROPN	NNP	Number=Sing	_	_	_	_
12	site	site	NOUN	NN	Number=Sing	_	_	_	_
13	were	be	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
14	unable	unable	ADJ	JJ	Degree=Pos	_	_	_	_
15	to	to	PART	TO	_	_	_	_	_
16	compete	compete	VERB	VB	VerbForm=Inf	_	_	_	_
17	for	for	ADP	IN	_	_	_	_	_
18	these	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
19	NF	Nf	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
20	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
21	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_
22	B	b	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
23	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
24	related	related	ADJ	JJ	Degree=Pos	_	_	_	_
25	proteins	protein	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
26	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1556
# text = Inducibility of endogenous IFN-beta and IFN-alpha RNA was also increased in PLB-IIIB cells.
1	Inducibility	Inducibility	NOUN	NN	Number=Sing	_	_	_	_
2	of	of	ADP	IN	_	_	_	_	_
3	endogenous	endogenous	ADJ	JJ	Degree=Pos	_	_	_	_
4	IFN	IFN	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
5	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
6	beta	beta	NOUN	NN	Number=Sing	_	_	_	_
7	and	and	CCONJ	CC	_	_	_	_	_
8	IFN	IFN	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
9	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
10	alpha	alpha	NOUN	NN	Number=Sing	_	_	_	_
11	RNA	RNA	PROPN	NNP	Number=Sing	_	_	_	_
12	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
13	also	also	ADV	RB	_	_	_	_	_
14	increased	increase	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
15	in	in	ADP	IN	_	_	_	_	_
16	PLB	PLB	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
17	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
18	IIIB	Iiib	PROPN	NNP	Number=Sing	_	_	_	_
19	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
20	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1557
# text = These studies indicate that HIV-1 infection of myelomonoblastic cells may select for a more mature monocytic phenotype and that unique subunit associations of NF-kappa B DNA binding proteins may contribute to differential NF-kappa B-mediated gene expression.
1	These	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
2	studies	study	NOUN	NNS	Number=Plur	_	_	_	_
3	indicate	indicate	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
4	that	that	SCONJ	IN	_	_	_	_	_
5	HIV	HIV	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
6	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
7	1	1	NUM	CD	NumType=Card	_	_	_	_
8	infection	infection	NOUN	NN	Number=Sing	_	_	_	_
9	of	of	ADP	IN	_	_	_	_	_
10	myelomonoblastic	myelomonoblastic	ADJ	JJ	Degree=Pos	_	_	_	_
11	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
12	may	may	AUX	MD	VerbForm=Fin	_	_	_	_
13	select	select	VERB	VB	VerbForm=Inf	_	_	_	_
14	for	for	ADP	IN	_	_	_	_	_
15	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
16	more	more	ADV	RBR	_	_	_	_	_
17	mature	mature	ADJ	JJ	Degree=Pos	_	_	_	_
18	monocytic	monocytic	ADJ	JJ	Degree=Pos	_	_	_	_
19	phenotype	phenotype	NOUN	NN	Number=Sing	_	_	_	_
20	and	and	CCONJ	CC	_	_	_	_	_
21	that	that	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
22	unique	unique	ADJ	JJ	Degree=Pos	_	_	_	_
23	subunit	subunit	NOUN	NN	Number=Sing	_	_	_	_
24	associations	association	NOUN	NNS	Number=Plur	_	_	_	_
25	of	of	ADP	IN	_	_	_	_	_
26	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
27	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
28	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_
29	B	b	NOUN	NN	Number=Sing	_	_	_	_
30	DNA	dna	NOUN	NN	Number=Sing	_	_	_	_
31	binding	bind	VERB	VBG	VerbForm=Ger	_	_	_	_
32	proteins	protein	NOUN	NNS	Number=Plur	_	_	_	_
33	may	may	AUX	MD	VerbForm=Fin	_	_	_	_
34	contribute	contribute	VERB	VB	VerbForm=Inf	_	_	_	_
35	to	to	PART	TO	_	_	_	_	_
36	differential	differential	VERB	VB	VerbForm=Inf	_	_	_	_
37	NF	NF	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
38	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
39	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_
40	B	b	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
41	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
42	mediated	mediate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
43	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
44	expression	expression	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
45	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 1558
# text = Document 003002567 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	003002567	003002567	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 1559
# text = NF-kappa B activity in T cells stably expressing the Tax protein of human T cell lymphotropic virus type I.
1	NF	Nf	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
2	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
3	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_
4	B	b	NOUN	NN	Number=Sing	_	_	_	_
5	activity	activity	NOUN	NN	Number=Sing	_	_	_	_
6	in	in	ADP	IN	_	_	_	_	_
7	T	t	PROPN	NNP	Number=Sing	_	_	_	_
8	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
9	stably	stably	ADV	RB	_	_	_	_	_
10	expressing	express	VERB	VBG	VerbForm=Ger	_	_	_	_
11	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
12	Tax	tax	NOUN	NN	Number=Sing	_	_	_	_
13	protein	protein	NOUN	NN	Number=Sing	_	_	_	_
14	of	of	ADP	IN	_	_	_	_	_
15	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
16	T	T	PROPN	NNP	Number=Sing	_	_	_	_
17	cell	cell	PROPN	NNP	Number=Sing	_	_	_	_
18	lymphotropic	lymphotropic	ADJ	JJ	Degree=Pos	_	_	_	_
19	virus	virus	NOUN	NN	Number=Sing	_	_	_	_
20	type	type	NOUN	NN	Number=Sing	_	_	_	_
21	I	I	PRON	PRP	Case=Nom|Number=Sing|Person=1|PronType=Prs	_	_	_	SpaceAfter=No
22	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 1560
# text = The effect of constitutive Tax expression on the interaction of NF-kappa B with its recognition sequence and on NF-kappa B-dependent gene expression was examined in T lymphoid Jurkat cell lines (19D and 9J) stably transformed with a Tax expression vector.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	effect	effect	NOUN	NN	Number=Sing	_	_	_	_
3	of	of	ADP	IN	_	_	_	_	_
4	constitutive	constitutive	ADJ	JJ	Degree=Pos	_	_	_	_
5	Tax	tax	NOUN	NN	Number=Sing	_	_	_	_
6	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
7	on	on	ADP	IN	_	_	_	_	_
8	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
9	interaction	interaction	NOUN	NN	Number=Sing	_	_	_	_
10	of	of	ADP	IN	_	_	_	_	_
11	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
12	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
13	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_
14	B	b	NOUN	NN	Number=Sing	_	_	_	_
15	with	with	ADP	IN	_	_	_	_	_
16	its	its	PRON	PRP$	Gender=Neut|Number=Sing|Person=3|Poss=Yes|PronType=Prs	_	_	_	_
17	recognition	recognition	NOUN	NN	Number=Sing	_	_	_	_
18	sequence	sequence	NOUN	NN	Number=Sing	_	_	_	_
19	and	and	CCONJ	CC	_	_	_	_	_
20	on	on	ADP	IN	_	_	_	_	_
21	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
22	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
23	kappa	kappa	PROPN	NNP	Number=Sing	_	_	_	_
24	B	b	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
25	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
26	dependent	dependent	ADJ	JJ	Degree=Pos	_	_	_	_
27	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
28	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
29	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
30	examined	examin	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
31	in	in	ADP	IN	_	_	_	_	_
32	T	t	PROPN	NNP	Number=Sing	_	_	_	_
33	lymphoid	lymphoid	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
34	Jurkat	Jurkat	PROPN	NNP	Number=Sing	_	_	_	_
35	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
36	lines	line	NOUN	NNS	Number=Plur	_	_	_	_
37	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
38	19D	19D	NOUN	NN	Number=Sing	_	_	_	_
39	and	and	CCONJ	CC	_	_	_	_	_
40	9J	9J	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
41	)	)	PUNCT	-RRB-	_	_	_	_	_
42	stably	stably	ADV	RB	_	_	_	_	_
43	transformed	transform	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
44	with	with	ADP	IN	_	_	_	_	_
45	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
46	Tax	tax	NOUN	NN	Number=Sing	_	_	_	_
47	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
48	vector	vector	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
49	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1561
# text = Tax expressing T cell lines contained a constitutive level of NF-kappa B binding activity, detectable by mobility shift assay and uv cross-linking using a palindromic NF-kappa B probe homologous to the interferon beta PRDII site.
1	Tax	tax	NOUN	NN	Number=Sing	_	_	_	_
2	expressing	express	VERB	VBG	VerbForm=Ger	_	_	_	_
3	T	t	NUM	CD	NumType=Card	_	_	_	_
4	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
5	lines	line	NOUN	NNS	Number=Plur	_	_	_	_
6	contained	contain	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
7	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
8	constitutive	constitutive	ADJ	JJ	Degree=Pos	_	_	_	_
9	level	level	NOUN	NN	Number=Sing	_	_	_	_
10	of	of	ADP	IN	_	_	_	_	_
11	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
12	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
13	kappa	kappa	PROPN	NNP	Number=Sing	_	_	_	_
14	B	b	PROPN	NNP	Number=Sing	_	_	_	_
15	binding	bind	VERB	VBG	VerbForm=Ger	_	_	_	_
16	activity	activity	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
17	,	,	PUNCT	,	_	_	_	_	_
18	detectable	detectable	ADJ	JJ	Degree=Pos	_	_	_	_
19	by	by	ADP	IN	_	_	_	_	_
20	mobility	mobility	NOUN	NN	Number=Sing	_	_	_	_
21	shift	shift	NOUN	NN	Number=Sing	_	_	_	_
22	assay	assay	NOUN	NN	Number=Sing	_	_	_	_
23	and	and	CCONJ	CC	_	_	_	_	_
24	uv	uv	NOUN	NN	Number=Sing	_	_	_	_
25	cross	cross	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
26	-linking	-link	VERB	VBG	VerbForm=Ger	_	_	_	_
27	using	use	VERB	VBG	VerbForm=Ger	_	_	_	_
28	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
29	palindromic	palindromic	ADJ	JJ	Degree=Pos	_	_	_	_
30	NF	Nf	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
31	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
32	kappa	kappa	PROPN	NNP	Number=Sing	_	_	_	_
33	B	b	PROPN	NNP	Number=Sing	_	_	_	_
34	probe	probe	ADV	RB	_	_	_	_	_
35	homologous	homologous	ADJ	JJ	Degree=Pos	_	_	_	_
36	to	to	ADP	IN	_	_	_	_	_
37	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
38	interferon	interferon	PROPN	NNP	Number=Sing	_	_	_	_
39	beta	beta	PROPN	NNP	Number=Sing	_	_	_	_
40	PRDII	Prdii	PROPN	NNP	Number=Sing	_	_	_	_
41	site	site	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
42	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1562
# text = In Jurkat and NC2.10 induction with phorbol esters resulted in the appearance of new DNA binding proteins of 85, 75, and 54 kDa, whereas in Tax expressing cells the 85-kDa protein and a 92-kDa DNA binding protein were constitutively induced.
1	In	in	ADP	IN	_	_	_	_	_
2	Jurkat	Jurkat	PROPN	NNP	Number=Sing	_	_	_	_
3	and	and	CCONJ	CC	_	_	_	_	_
4	NC2.10	NC2.10	NUM	CD	NumType=Card	_	_	_	_
5	induction	induction	NOUN	NN	Number=Sing	_	_	_	_
6	with	with	ADP	IN	_	_	_	_	_
7	phorbol	phorbol	NOUN	NN	Number=Sing	_	_	_	_
8	esters	ester	NOUN	NNS	Number=Plur	_	_	_	_
9	resulted	result	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
10	in	in	ADP	IN	_	_	_	_	_
11	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
12	appearance	appearance	NOUN	NN	Number=Sing	_	_	_	_
13	of	of	ADP	IN	_	_	_	_	_
14	new	new	ADJ	JJ	Degree=Pos	_	_	_	_
15	DNA	dna	NOUN	NN	Number=Sing	_	_	_	_
16	binding	binding	VERB	VBG	VerbForm=Ger	_	_	_	_
17	proteins	protein	NOUN	NNS	Number=Plur	_	_	_	_
18	of	of	ADP	IN	_	_	_	_	_
19	85	85	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
20	,	,	PUNCT	,	_	_	_	_	_
21	75	75	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
22	,	,	PUNCT	,	_	_	_	_	_
23	and	and	CCONJ	CC	_	_	_	_	_
24	54	54	NUM	CD	NumType=Card	_	_	_	_
25	kDa	kDa	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
26	,	,	PUNCT	,	_	_	_	_	_
27	whereas	wherea	SCONJ	IN	_	_	_	_	_
28	in	in	ADP	IN	_	_	_	_	_
29	Tax	Tax	NOUN	NN	Number=Sing	_	_	_	_
30	expressing	expresse	VERB	VBG	VerbForm=Ger	_	_	_	_
31	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
32	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
33	85	85	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
34	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
35	kDa	kDa	NOUN	NN	Number=Sing	_	_	_	_
36	protein	protein	NOUN	NN	Number=Sing	_	_	_	_
37	and	and	CCONJ	CC	_	_	_	_	_
38	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
39	92	92	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
40	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
41	kDa	kDa	NOUN	NN	Number=Sing	_	_	_	_
42	DNA	dna	NOUN	NN	Number=Sing	_	_	_	_
43	binding	bind	VERB	VBG	VerbForm=Ger	_	_	_	_
44	protein	protein	NOUN	NN	Number=Sing	_	_	_	_
45	were	be	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
46	constitutively	constitutively	ADV	RB	_	_	_	_	_
47	induced	induce	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	SpaceAfter=No
48	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1563
# text = Expression of Tax protein in 19D and 9J resulted in transcription of the endogenous NF-kappa B-dependent granulocyte-macrophage colony stimulating factor gene and increased basal level expression of transfected NF-kappa B-regulated promoters.
1	Expression	expression	NOUN	NN	Number=Sing	_	_	_	_
2	of	of	ADP	IN	_	_	_	_	_
3	Tax	tax	NOUN	NN	Number=Sing	_	_	_	_
4	protein	protein	NOUN	NN	Number=Sing	_	_	_	_
5	in	in	ADP	IN	_	_	_	_	_
6	19D	19D	PROPN	NNP	Number=Sing	_	_	_	_
7	and	and	CCONJ	CC	_	_	_	_	_
8	9J	9J	PROPN	NNP	Number=Sing	_	_	_	_
9	resulted	result	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
10	in	in	ADP	IN	_	_	_	_	_
11	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
12	of	of	ADP	IN	_	_	_	_	_
13	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
14	endogenous	endogenous	ADJ	JJ	Degree=Pos	_	_	_	_
15	NF	NF	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
16	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
17	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_
18	B	b	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
19	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
20	dependent	dependent	ADJ	JJ	Degree=Pos	_	_	_	_
21	granulocyte	granulocyte	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
22	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
23	macrophage	macrophage	NOUN	NN	Number=Sing	_	_	_	_
24	colony	colony	NOUN	NN	Number=Sing	_	_	_	_
25	stimulating	stimulate	VERB	VBG	VerbForm=Ger	_	_	_	_
26	factor	factor	NOUN	NN	Number=Sing	_	_	_	_
27	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
28	and	and	CCONJ	CC	_	_	_	_	_
29	increased	increase	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
30	basal	basal	ADJ	JJ	Degree=Pos	_	_	_	_
31	level	level	NOUN	NN	Number=Sing	_	_	_	_
32	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
33	of	of	ADP	IN	_	_	_	_	_
34	transfected	transfect	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
35	NF	NF	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
36	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
37	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_
38	B	b	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
39	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
40	regulated	regulate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
41	promoters	promoter	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
42	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1564
# text = Nonetheless transcription of both the endogenous and the transfected gene was inducible by PMA treatment.
1	Nonetheless	nonetheless	ADJ	JJ	Degree=Pos	_	_	_	_
2	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
3	of	of	ADP	IN	_	_	_	_	_
4	both	both	CCONJ	CC	_	_	_	_	_
5	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
6	endogenous	endogenous	ADJ	JJ	Degree=Pos	_	_	_	_
7	and	and	CCONJ	CC	_	_	_	_	_
8	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
9	transfected	transfect	ADJ	JJ	Degree=Pos	_	_	_	_
10	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
11	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
12	inducible	inducible	ADJ	JJ	Degree=Pos	_	_	_	_
13	by	by	ADP	IN	_	_	_	_	_
14	PMA	PMA	PROPN	NNP	Number=Sing	_	_	_	_
15	treatment	treatment	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
16	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1565
# text = Tax expression in Jurkat
1	Tax	tax	NOUN	NN	Number=Sing	_	_	_	_
2	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
3	in	in	ADP	IN	_	_	_	_	_
4	Jurkat	Jurkat	PROPN	NNP	Number=Sing	_	_	_	_

# sent_id = 1566
# text = T cells may alter the stoichiometry of NF-kappa B DNA binding proteins and thus change the expression of NF-kappa B-regulated promoters.
1	T	t	ADJ	JJ	Degree=Pos	_	_	_	_
2	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
3	may	may	AUX	MD	VerbForm=Fin	_	_	_	_
4	alter	alter	VERB	VB	VerbForm=Inf	_	_	_	_
5	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
6	stoichiometry	stoichiometry	NOUN	NN	Number=Sing	_	_	_	_
7	of	of	ADP	IN	_	_	_	_	_
8	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
9	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
10	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_
11	B	b	NOUN	NN	Number=Sing	_	_	_	_
12	DNA	dna	NOUN	NN	Number=Sing	_	_	_	_
13	binding	bind	VERB	VBG	VerbForm=Ger	_	_	_	_
14	proteins	protein	NOUN	NNS	Number=Plur	_	_	_	_
15	and	and	CCONJ	CC	_	_	_	_	_
16	thus	thus	ADV	RB	_	_	_	_	_
17	change	change	VERB	VB	VerbForm=Inf	_	_	_	_
18	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
19	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
20	of	of	ADP	IN	_	_	_	_	_
21	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
22	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
23	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_
24	B	b	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
25	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
26	regulated	regulate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
27	promoters	promoter	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
28	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 1567
# text = Document 003002568 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	003002568	003002568	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 1568
# text = Identification and characterization of a leukocyte-specific component of the nuclear body.
1	Identification	identification	NOUN	NN	Number=Sing	_	_	_	_
2	and	and	CCONJ	CC	_	_	_	_	_
3	characterization	characterization	NOUN	NN	Number=Sing	_	_	_	_
4	of	of	ADP	IN	_	_	_	_	_
5	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
6	leukocyte	leukocyte	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
7	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
8	specific	specific	ADJ	JJ	Degree=Pos	_	_	_	_
9	component	component	NOUN	NN	Number=Sing	_	_	_	_
10	of	of	ADP	IN	_	_	_	_	_
11	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
12	nuclear	nuclear	ADJ	JJ	Degree=Pos	_	_	_	_
13	body	body	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
14	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 1569
# text = The nuclear body (NB) is a cellular organelle that is involved in the pathogenesis of acute promyelocytic leukemia and viral infection.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	nuclear	nuclear	ADJ	JJ	Degree=Pos	_	_	_	_
3	body	body	NOUN	NN	Number=Sing	_	_	_	_
4	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
5	NB	NB	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
6	)	)	PUNCT	-RRB-	_	_	_	_	_
7	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
8	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
9	cellular	cellular	ADJ	JJ	Degree=Pos	_	_	_	_
10	organelle	organelle	NOUN	NN	Number=Sing	_	_	_	_
11	that	that	PRON	WDT	PronType=Rel	_	_	_	_
12	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
13	involved	involved	ADJ	JJ	Degree=Pos	_	_	_	_
14	in	in	ADP	IN	_	_	_	_	_
15	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
16	pathogenesis	pathogenesis	NOUN	NN	Number=Sing	_	_	_	_
17	of	of	ADP	IN	_	_	_	_	_
18	acute	acute	ADJ	JJ	Degree=Pos	_	_	_	_
19	promyelocytic	promyelocytic	ADJ	JJ	Degree=Pos	_	_	_	_
20	leukemia	leukemia	NOUN	NN	Number=Sing	_	_	_	_
21	and	and	CCONJ	CC	_	_	_	_	_
22	viral	viral	ADJ	JJ	Degree=Pos	_	_	_	_
23	infection	infection	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
24	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1570
# text = The NB is also a target of antibodies in the serum of patients with the autoimmune disease primary biliary cirrhosis.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	NB	Nb	NOUN	NN	Number=Sing	_	_	_	_
3	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
4	also	also	ADV	RB	_	_	_	_	_
5	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
6	target	target	NOUN	NN	Number=Sing	_	_	_	_
7	of	of	ADP	IN	_	_	_	_	_
8	antibodies	antibody	NOUN	NNS	Number=Plur	_	_	_	_
9	in	in	ADP	IN	_	_	_	_	_
10	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
11	serum	serum	NOUN	NN	Number=Sing	_	_	_	_
12	of	of	ADP	IN	_	_	_	_	_
13	patients	patient	NOUN	NNS	Number=Plur	_	_	_	_
14	with	with	ADP	IN	_	_	_	_	_
15	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
16	autoimmune	autoimmune	ADJ	JJ	Degree=Pos	_	_	_	_
17	disease	disease	NOUN	NN	Number=Sing	_	_	_	_
18	primary	primary	ADJ	JJ	Degree=Pos	_	_	_	_
19	biliary	biliary	ADJ	JJ	Degree=Pos	_	_	_	_
20	cirrhosis	cirrhosis	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
21	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1571
# text = In this study, serum from a patient with primary biliary cirrhosis was used to identify a cDNA encoding a novel component of the NB, a 140-kDa protein designated Sp140.
1	In	in	ADP	IN	_	_	_	_	_
2	this	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
3	study	study	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
4	,	,	PUNCT	,	_	_	_	_	_
5	serum	serum	NOUN	NN	Number=Sing	_	_	_	_
6	from	from	ADP	IN	_	_	_	_	_
7	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
8	patient	patient	NOUN	NN	Number=Sing	_	_	_	_
9	with	with	ADP	IN	_	_	_	_	_
10	primary	primary	ADJ	JJ	Degree=Pos	_	_	_	_
11	biliary	biliary	ADJ	JJ	Degree=Pos	_	_	_	_
12	cirrhosis	cirrhosis	NOUN	NN	Number=Sing	_	_	_	_
13	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
14	used	use	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
15	to	to	PART	TO	_	_	_	_	_
16	identify	identify	VERB	VB	VerbForm=Inf	_	_	_	_
17	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
18	cDNA	cDNa	NOUN	NN	Number=Sing	_	_	_	_
19	encoding	encod	VERB	VBG	VerbForm=Ger	_	_	_	_
20	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
21	novel	novel	NOUN	NN	Number=Sing	_	_	_	_
22	component	component	NOUN	NN	Number=Sing	_	_	_	_
23	of	of	ADP	IN	_	_	_	_	_
24	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
25	NB	NB	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
26	,	,	PUNCT	,	_	_	_	_	_
27	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
28	140	140	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
29	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
30	kDa	kDa	NOUN	NN	Number=Sing	_	_	_	_
31	protein	protein	NOUN	NN	Number=Sing	_	_	_	_
32	designated	designate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
33	Sp140	Sp140	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
34	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1572
# text = The predicted amino acid sequence of the amino-terminal portion of Sp140 was similar to Sp100, a previously identified NB protein.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	predicted	predict	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
3	amino	amino	DET	DT	_	_	_	_	_
4	acid	acid	ADJ	JJ	Degree=Pos	_	_	_	_
5	sequence	sequence	NOUN	NN	Number=Sing	_	_	_	_
6	of	of	ADP	IN	_	_	_	_	_
7	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
8	amino	amino	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
9	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
10	terminal	terminal	ADJ	JJ	Degree=Pos	_	_	_	_
11	portion	portion	NOUN	NN	Number=Sing	_	_	_	_
12	of	of	ADP	IN	_	_	_	_	_
13	Sp140	Sp140	PROPN	NNP	Number=Sing	_	_	_	_
14	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
15	similar	similar	ADJ	JJ	Degree=Pos	_	_	_	_
16	to	to	ADP	IN	_	_	_	_	_
17	Sp100	Sp100	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
18	,	,	PUNCT	,	_	_	_	_	_
19	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
20	previously	previously	ADV	RB	_	_	_	_	_
21	identified	identify	ADJ	JJ	Degree=Pos	_	_	_	_
22	NB	NB	PROPN	NNP	Number=Sing	_	_	_	_
23	protein	protein	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
24	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1573
# text = The carboxyl portion of Sp140 contained a zinc-finger domain and a bromodomain, motifs that are present in proteins regulating gene transcription.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	carboxyl	carboxyl	NOUN	NN	Number=Sing	_	_	_	_
3	portion	portion	NOUN	NN	Number=Sing	_	_	_	_
4	of	of	ADP	IN	_	_	_	_	_
5	Sp140	Sp140	PROPN	NNP	Number=Sing	_	_	_	_
6	contained	contain	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
7	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
8	zinc	zinc	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
9	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
10	finger	finger	NOUN	NN	Number=Sing	_	_	_	_
11	domain	domain	NOUN	NN	Number=Sing	_	_	_	_
12	and	and	CCONJ	CC	_	_	_	_	_
13	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
14	bromodomain	bromodomain	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
15	,	,	PUNCT	,	_	_	_	_	_
16	motifs	motif	NOUN	NNS	Number=Plur	_	_	_	_
17	that	that	PRON	WDT	PronType=Rel	_	_	_	_
18	are	be	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
19	present	present	ADJ	JJ	Degree=Pos	_	_	_	_
20	in	in	ADP	IN	_	_	_	_	_
21	proteins	protein	NOUN	NNS	Number=Plur	_	_	_	_
22	regulating	regulate	VERB	VBG	VerbForm=Ger	_	_	_	_
23	gene	gene	ADJ	JJ	Degree=Pos	_	_	_	_
24	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
25	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1574
# text = High levels of Sp140 mRNA were detected in human spleen and peripheral blood leukocytes, but not other human tissues.
1	High	high	ADJ	JJ	Degree=Pos	_	_	_	_
2	levels	level	NOUN	NNS	Number=Plur	_	_	_	_
3	of	of	ADP	IN	_	_	_	_	_
4	Sp140	Sp140	PROPN	NNP	Number=Sing	_	_	_	_
5	mRNA	mRNA	PROPN	NNP	Number=Sing	_	_	_	_
6	were	be	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
7	detected	detect	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
8	in	in	ADP	IN	_	_	_	_	_
9	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
10	spleen	spleen	NOUN	NNS	Number=Plur	_	_	_	_
11	and	and	CCONJ	CC	_	_	_	_	_
12	peripheral	peripheral	ADJ	JJ	Degree=Pos	_	_	_	_
13	blood	blood	NOUN	NN	Number=Sing	_	_	_	_
14	leukocytes	leukocyte	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
15	,	,	PUNCT	,	_	_	_	_	_
16	but	but	CCONJ	CC	_	_	_	_	_
17	not	not	ADV	RB	_	_	_	_	_
18	other	other	ADJ	JJ	Degree=Pos	_	_	_	_
19	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
20	tissues	tissue	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
21	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1575
# text = The level of SP140 mRNA in myeloid precursor cell lines HL60 and NB4 markedly increased in response to chemically induced cellular differentiation.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	level	level	NOUN	NN	Number=Sing	_	_	_	_
3	of	of	ADP	IN	_	_	_	_	_
4	SP	sp	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
5	140	140	NUM	CD	NumType=Card	_	_	_	_
6	mRNA	mRNa	NOUN	NN	Number=Sing	_	_	_	_
7	in	in	ADP	IN	_	_	_	_	_
8	myeloid	myeloid	ADJ	JJ	Degree=Pos	_	_	_	_
9	precursor	precursor	ADJ	JJ	Degree=Pos	_	_	_	_
10	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
11	lines	line	NOUN	NNS	Number=Plur	_	_	_	_
12	HL60	HL60	PROPN	NNP	Number=Sing	_	_	_	_
13	and	and	CCONJ	CC	_	_	_	_	_
14	NB4	NB4	PROPN	NNP	Number=Sing	_	_	_	_
15	markedly	markedly	ADV	RB	_	_	_	_	_
16	increased	increase	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
17	in	in	ADP	IN	_	_	_	_	_
18	response	response	NOUN	NN	Number=Sing	_	_	_	_
19	to	to	PART	TO	_	_	_	_	_
20	chemically	chemically	ADV	RB	_	_	_	_	_
21	induced	induce	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
22	cellular	cellular	ADJ	JJ	Degree=Pos	_	_	_	_
23	differentiation	differentiation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
24	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1576
# text = Immunohistochemical techniques were used to demonstrate that SP140 localized to the NB in differentiated HL60 and NB4 cells.
1	Immunohistochemical	Immunohistochemical	ADJ	JJ	Degree=Pos	_	_	_	_
2	techniques	technique	NOUN	NNS	Number=Plur	_	_	_	_
3	were	be	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
4	used	use	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
5	to	to	PART	TO	_	_	_	_	_
6	demonstrate	demonstrate	VERB	VB	VerbForm=Inf	_	_	_	_
7	that	that	SCONJ	IN	_	_	_	_	_
8	SP	sp	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
9	140	140	NUM	CD	NumType=Card	_	_	_	_
10	localized	localize	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
11	to	to	ADP	IN	_	_	_	_	_
12	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
13	NB	NB	PROPN	NNP	Number=Sing	_	_	_	_
14	in	in	ADP	IN	_	_	_	_	_
15	differentiated	differentiated	PROPN	NNP	Number=Sing	_	_	_	_
16	HL60	HL60	PROPN	NNP	Number=Sing	_	_	_	_
17	and	and	CCONJ	CC	_	_	_	_	_
18	NB4	NB4	PROPN	NNP	Number=Sing	_	_	_	_
19	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
20	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1577
# text = The location of Sp140 in the NB, and expression of this gene in cells involved in host defense, suggest that Sp140 may be involved in the pathogenesis of acute promyelocytic leukemia and viral infection.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	location	location	NOUN	NN	Number=Sing	_	_	_	_
3	of	of	ADP	IN	_	_	_	_	_
4	Sp140	Sp140	NUM	CD	NumType=Card	_	_	_	_
5	in	in	ADP	IN	_	_	_	_	_
6	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
7	NB	NB	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
8	,	,	PUNCT	,	_	_	_	_	_
9	and	and	CCONJ	CC	_	_	_	_	_
10	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
11	of	of	ADP	IN	_	_	_	_	_
12	this	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
13	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
14	in	in	ADP	IN	_	_	_	_	_
15	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
16	involved	involved	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
17	in	in	ADP	IN	_	_	_	_	_
18	host	host	NOUN	NN	Number=Sing	_	_	_	_
19	defense	defense	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
20	,	,	PUNCT	,	_	_	_	_	_
21	suggest	suggest	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
22	that	that	SCONJ	IN	_	_	_	_	_
23	Sp140	Sp140	PROPN	NNP	Number=Sing	_	_	_	_
24	may	may	AUX	MD	VerbForm=Fin	_	_	_	_
25	be	be	AUX	VB	VerbForm=Inf	_	_	_	_
26	involved	involved	ADJ	JJ	Degree=Pos	_	_	_	_
27	in	in	ADP	IN	_	_	_	_	_
28	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
29	pathogenesis	pathogenesis	NOUN	NN	Number=Sing	_	_	_	_
30	of	of	ADP	IN	_	_	_	_	_
31	acute	acute	ADJ	JJ	Degree=Pos	_	_	_	_
32	promyelocytic	promyelocytic	ADJ	JJ	Degree=Pos	_	_	_	_
33	leukemia	leukemia	NOUN	NN	Number=Sing	_	_	_	_
34	and	and	CCONJ	CC	_	_	_	_	_
35	viral	viral	ADJ	JJ	Degree=Pos	_	_	_	_
36	infection	infection	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
37	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 1578
# text = Document 003002570 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	003002570	003002570	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 1579
# text = Activation of pp90rsk and early growth response-1 gene expression by pokeweed mitogen in human B cells.
1	Activation	Activation	NOUN	NN	Number=Sing	_	_	_	_
2	of	of	ADP	IN	_	_	_	_	_
3	pp90rsk	pp90rsk	NOUN	NN	Number=Sing	_	_	_	_
4	and	and	CCONJ	CC	_	_	_	_	_
5	early	early	ADJ	JJ	Degree=Pos	_	_	_	_
6	growth	growth	NOUN	NN	Number=Sing	_	_	_	_
7	response	response	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
8	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
9	1	1	NUM	CD	NumType=Card	_	_	_	_
10	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
11	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
12	by	by	ADP	IN	_	_	_	_	_
13	pokeweed	pokeweed	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
14	mitogen	mitogen	NOUN	NNS	Number=Plur	_	_	_	_
15	in	in	ADP	IN	_	_	_	_	_
16	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
17	B	b	ADJ	JJ	Degree=Pos	_	_	_	_
18	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
19	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 1580
# text = The present studies have examined the effects of pokeweed mitogen (PWM) on the induction of early growth response-1 gene (EGR-1) in normal human B cells.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	present	present	ADJ	JJ	Degree=Pos	_	_	_	_
3	studies	study	NOUN	NNS	Number=Plur	_	_	_	_
4	have	have	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
5	examined	examine	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
6	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
7	effects	effect	NOUN	NNS	Number=Plur	_	_	_	_
8	of	of	ADP	IN	_	_	_	_	_
9	pokeweed	pokeweed	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
10	mitogen	mitogen	NOUN	NNS	Number=Plur	_	_	_	_
11	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
12	PWM	PWM	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
13	)	)	PUNCT	-RRB-	_	_	_	_	_
14	on	on	ADP	IN	_	_	_	_	_
15	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
16	induction	induction	NOUN	NN	Number=Sing	_	_	_	_
17	of	of	ADP	IN	_	_	_	_	_
18	early	early	ADJ	JJ	Degree=Pos	_	_	_	_
19	growth	growth	NOUN	NN	Number=Sing	_	_	_	_
20	response	response	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
21	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
22	1	1	NUM	CD	NumType=Card	_	_	_	_
23	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
24	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
25	EGR	EGR	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
26	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
27	1	1	X	LS	_	_	_	_	SpaceAfter=No
28	)	)	PUNCT	-RRB-	_	_	_	_	_
29	in	in	ADP	IN	_	_	_	_	_
30	normal	normal	ADJ	JJ	Degree=Pos	_	_	_	_
31	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
32	B	b	NOUN	NN	Number=Sing	_	_	_	_
33	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
34	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1581
# text = PWM regulates EGR-1 gene expression by both transcriptional and post-transcriptional mechanisms.
1	PWM	PWM	PRON	PRP	Case=Acc|Number=Plur|Person=3|PronType=Prs	_	_	_	_
2	regulates	regulate	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
3	EGR	EGR	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
4	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
5	1	1	NUM	CD	NumType=Card	_	_	_	_
6	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
7	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
8	by	by	ADP	IN	_	_	_	_	_
9	both	both	CCONJ	CC	_	_	_	_	_
10	transcriptional	transcriptional	ADJ	JJ	Degree=Pos	_	_	_	_
11	and	and	CCONJ	CC	_	_	_	_	_
12	post-transcriptional	post-transcriptional	ADJ	JJ	Degree=Pos	_	_	_	_
13	mechanisms	mechanism	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
14	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1582
# text = Transient transfection assays with EGR-1 promoter fragments linked to the chloramphenicol acetyltransferase (CAT) gene demonstrated that PWM induced EGR-1 transcription is conferred by the CArG motif (C C[AT]6GG) in the EGR-1 promoter.
1	Transient	Transient	ADJ	JJ	Degree=Pos	_	_	_	_
2	transfection	transfection	NOUN	NN	Number=Sing	_	_	_	_
3	assays	assay	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
4	with	with	ADP	IN	_	_	_	_	_
5	EGR	EGR	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
6	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
7	1	1	NUM	CD	NumType=Card	_	_	_	_
8	promoter	promoter	NOUN	NN	Number=Sing	_	_	_	_
9	fragments	fragment	NOUN	NNS	Number=Plur	_	_	_	_
10	linked	link	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
11	to	to	ADP	IN	_	_	_	_	_
12	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
13	chloramphenicol	chloramphenicol	NOUN	NN	Number=Sing	_	_	_	_
14	acetyltransferase	acetyltransferase	NOUN	NN	Number=Sing	_	_	_	_
15	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
16	CAT	cat	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
17	)	)	PUNCT	-RRB-	_	_	_	_	_
18	gene	gene	PRON	NN	Number=Sing	_	_	_	_
19	demonstrated	demonstrate	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
20	that	that	SCONJ	IN	_	_	_	_	_
21	PWM	PWM	PROPN	NNP	Number=Sing	_	_	_	_
22	induced	induce	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
23	EGR	EGR	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
24	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
25	1	1	NUM	CD	NumType=Card	_	_	_	_
26	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
27	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
28	conferred	confer	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
29	by	by	ADP	IN	_	_	_	_	_
30	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
31	CArG	CArG	PROPN	NNP	Number=Sing	_	_	_	_
32	motif	motif	NOUN	NN	Number=Sing	_	_	_	_
33	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
34	C	C	PROPN	NNP	Number=Sing	_	_	_	_
35	C	C	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
36	[	[	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
37	AT	at	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
38	]	]	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
39	6GG	6gg	INTJ	UH	_	_	_	_	SpaceAfter=No
40	)	)	PUNCT	-RRB-	_	_	_	_	_
41	in	in	ADP	IN	_	_	_	_	_
42	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
43	EGR	Egr	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
44	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
45	1	1	NUM	CD	NumType=Card	_	_	_	_
46	promoter	promoter	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
47	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1583
# text = The results further demonstrated the activation of S6 kinase (pp90rsk), evidenced by phosphorylation of S6 and serum response factor (SRF) peptides, in PWM treated B cells.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	results	result	NOUN	NNS	Number=Plur	_	_	_	_
3	further	further	ADV	RB	_	_	_	_	_
4	demonstrated	demonstrate	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
5	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
6	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
7	of	of	ADP	IN	_	_	_	_	_
8	S6	S6	NUM	CD	NumType=Card	_	_	_	_
9	kinase	kinase	NOUN	NN	Number=Sing	_	_	_	_
10	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
11	pp90rsk	pp90rsk	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
12	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
13	,	,	PUNCT	,	_	_	_	_	_
14	evidenced	evidence	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
15	by	by	ADP	IN	_	_	_	_	_
16	phosphorylation	phosphorylation	NOUN	NN	Number=Sing	_	_	_	_
17	of	of	ADP	IN	_	_	_	_	_
18	S6	s6	NOUN	NN	Number=Sing	_	_	_	_
19	and	and	CCONJ	CC	_	_	_	_	_
20	serum	serum	NOUN	NN	Number=Sing	_	_	_	_
21	response	response	NOUN	NN	Number=Sing	_	_	_	_
22	factor	factor	NOUN	NN	Number=Sing	_	_	_	_
23	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
24	SRF	SRF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
25	)	)	PUNCT	-RRB-	_	_	_	_	_
26	peptides	peptide	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
27	,	,	PUNCT	,	_	_	_	_	_
28	in	in	ADP	IN	_	_	_	_	_
29	PWM	PWM	PROPN	NNP	Number=Sing	_	_	_	_
30	treated	treat	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
31	B	b	ADJ	JJ	Degree=Pos	_	_	_	_
32	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
33	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1584
# text = Taken together, these findings suggest that PWM is able to initiate an intracytoplasmic signalling cascade and EGR-1 induction in normal human B cells.
1	Taken	take	PROPN	NNP	Number=Sing	_	_	_	_
2	together	together	ADV	RB	_	_	_	_	SpaceAfter=No
3	,	,	PUNCT	,	_	_	_	_	_
4	these	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
5	findings	finding	NOUN	NNS	Number=Plur	_	_	_	_
6	suggest	suggest	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
7	that	that	SCONJ	IN	_	_	_	_	_
8	PWM	PWM	PROPN	NNP	Number=Sing	_	_	_	_
9	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
10	able	able	ADJ	JJ	Degree=Pos	_	_	_	_
11	to	to	PART	TO	_	_	_	_	_
12	initiate	initiate	VERB	VB	VerbForm=Inf	_	_	_	_
13	an	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
14	intracytoplasmic	intracytoplasmic	ADJ	JJ	Degree=Pos	_	_	_	_
15	signalling	signalling	NOUN	NN	Number=Sing	_	_	_	_
16	cascade	cascade	NOUN	NN	Number=Sing	_	_	_	_
17	and	and	CCONJ	CC	_	_	_	_	_
18	EGR	Egr	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
19	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
20	1	1	NUM	CD	NumType=Card	_	_	_	_
21	induction	induction	NOUN	NN	Number=Sing	_	_	_	_
22	in	in	ADP	IN	_	_	_	_	_
23	normal	normal	ADJ	JJ	Degree=Pos	_	_	_	_
24	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
25	B	b	NOUN	NN	Number=Sing	_	_	_	_
26	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
27	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 1585
# text = Document 003002578 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	003002578	003002578	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 1586
# text = Autoregulation of the NF-kappa B transactivator RelA (p65) by multiple cytoplasmic inhibitors containing ankyrin motifs.
1	Autoregulation	Autoregulation	NOUN	NN	Number=Sing	_	_	_	_
2	of	of	ADP	IN	_	_	_	_	_
3	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
4	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
5	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
6	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_
7	B	b	NOUN	NN	Number=Sing	_	_	_	_
8	transactivator	transactivator	NOUN	NN	Number=Sing	_	_	_	_
9	RelA	RelA	PROPN	NNP	Number=Sing	_	_	_	_
10	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
11	p65	p65	X	LS	_	_	_	_	SpaceAfter=No
12	)	)	PUNCT	-RRB-	_	_	_	_	_
13	by	by	ADP	IN	_	_	_	_	_
14	multiple	multiple	ADJ	JJ	Degree=Pos	_	_	_	_
15	cytoplasmic	cytoplasmic	ADJ	JJ	Degree=Pos	_	_	_	_
16	inhibitors	inhibitor	NOUN	NNS	Number=Plur	_	_	_	_
17	containing	contain	VERB	VBG	VerbForm=Ger	_	_	_	_
18	ankyrin	ankyrin	ADP	IN	_	_	_	_	_
19	motifs	motif	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
20	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 1587
# text = RelA (p65) functions as the critical transactivating component of the heterodimeric p50-p65 NF-kappa B complex and contains a high-affinity binding site for its cytoplasmic inhibitor, I kappa B alpha.
1	RelA	Rela	NOUN	NN	Number=Sing	_	_	_	_
2	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
3	p65	p65	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
4	)	)	PUNCT	-RRB-	_	_	_	_	_
5	functions	function	NOUN	NNS	Number=Plur	_	_	_	_
6	as	as	ADP	IN	_	_	_	_	_
7	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
8	critical	critical	ADJ	JJ	Degree=Pos	_	_	_	_
9	transactivating	transactivating	NOUN	NN	Number=Sing	_	_	_	_
10	component	component	NOUN	NN	Number=Sing	_	_	_	_
11	of	of	ADP	IN	_	_	_	_	_
12	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
13	heterodimeric	heterodimeric	ADJ	JJ	Degree=Pos	_	_	_	_
14	p50	p50	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
15	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
16	p65	p65	NOUN	NN	Number=Sing	_	_	_	_
17	NF	Nf	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
18	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
19	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_
20	B	b	NOUN	NN	Number=Sing	_	_	_	_
21	complex	complex	NOUN	NN	Number=Sing	_	_	_	_
22	and	and	CCONJ	CC	_	_	_	_	_
23	contains	contain	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
24	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
25	high	high	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
26	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
27	affinity	affinity	NOUN	NN	Number=Sing	_	_	_	_
28	binding	bind	VERB	VBG	VerbForm=Ger	_	_	_	_
29	site	site	NOUN	NN	Number=Sing	_	_	_	_
30	for	for	ADP	IN	_	_	_	_	_
31	its	its	PRON	PRP$	Gender=Neut|Number=Sing|Person=3|Poss=Yes|PronType=Prs	_	_	_	_
32	cytoplasmic	cytoplasmic	ADJ	JJ	Degree=Pos	_	_	_	_
33	inhibitor	inhibitor	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
34	,	,	PUNCT	,	_	_	_	_	_
35	I	I	PRON	PRP	Case=Nom|Number=Sing|Person=1|PronType=Prs	_	_	_	_
36	kappa	kappa	PROPN	NNP	Number=Sing	_	_	_	_
37	B	b	PROPN	NNP	Number=Sing	_	_	_	_
38	alpha	alpha	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
39	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1588
# text = After cellular activation, I kappa B alpha is rapidly degraded in concert with the induced nuclear translocation of NF-kappa B.
1	After	after	ADP	IN	_	_	_	_	_
2	cellular	cellular	ADJ	JJ	Degree=Pos	_	_	_	_
3	activation	activation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
4	,	,	PUNCT	,	_	_	_	_	_
5	I	I	PRON	PRP	Case=Nom|Number=Sing|Person=1|PronType=Prs	_	_	_	_
6	kappa	kappa	X	FW	Foreign=Yes	_	_	_	_
7	B	b	ADJ	JJ	Degree=Pos	_	_	_	_
8	alpha	alpha	NOUN	NN	Number=Sing	_	_	_	_
9	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
10	rapidly	rapidly	ADV	RB	_	_	_	_	_
11	degraded	degrad	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
12	in	in	ADP	IN	_	_	_	_	_
13	concert	concert	NOUN	NN	Number=Sing	_	_	_	_
14	with	with	ADP	IN	_	_	_	_	_
15	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
16	induced	induce	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
17	nuclear	nuclear	ADJ	JJ	Degree=Pos	_	_	_	_
18	translocation	translocation	NOUN	NN	Number=Sing	_	_	_	_
19	of	of	ADP	IN	_	_	_	_	_
20	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
21	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
22	kappa	kappa	PROPN	NNP	Number=Sing	_	_	_	_
23	B	b	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
24	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1589
# text = The present study demonstrates that tumor necrosis factor alpha-induced degradation of I kappa B alpha in human T cells is preceded by its rapid phosphorylation in vivo.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	present	present	ADJ	JJ	Degree=Pos	_	_	_	_
3	study	study	NOUN	NN	Number=Sing	_	_	_	_
4	demonstrates	demonstrate	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
5	that	that	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
6	tumor	tumor	NOUN	NN	Number=Sing	_	_	_	_
7	necrosis	necrosis	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
8	factor	factor	NOUN	NN	Number=Sing	_	_	_	_
9	alpha	alpha	ADV	RB	_	_	_	_	SpaceAfter=No
10	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
11	induced	induce	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
12	degradation	degradation	NOUN	NN	Number=Sing	_	_	_	_
13	of	of	ADP	IN	_	_	_	_	_
14	I	I	PRON	PRP	Case=Nom|Number=Sing|Person=1|PronType=Prs	_	_	_	_
15	kappa	kappa	PROPN	NNP	Number=Sing	_	_	_	_
16	B	b	PROPN	NNP	Number=Sing	_	_	_	_
17	alpha	alpha	NOUN	NN	Number=Sing	_	_	_	_
18	in	in	ADP	IN	_	_	_	_	_
19	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
20	T	T	PROPN	NNP	Number=Sing	_	_	_	_
21	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
22	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
23	preceded	preced	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
24	by	by	ADP	IN	_	_	_	_	_
25	its	its	PRON	PRP$	Gender=Neut|Number=Sing|Person=3|Poss=Yes|PronType=Prs	_	_	_	_
26	rapid	rapid	ADJ	JJ	Degree=Pos	_	_	_	_
27	phosphorylation	phosphorylation	NOUN	NN	Number=Sing	_	_	_	_
28	in	in	ADP	IN	_	_	_	_	_
29	vivo	vivo	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
30	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1590
# text = However, these effects on I kappa B alpha result in nuclear mobilization of only a fraction of the entire cytoplasmic pool of RelA.
1	However	however	ADV	RB	_	_	_	_	SpaceAfter=No
2	,	,	PUNCT	,	_	_	_	_	_
3	these	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
4	effects	effect	NOUN	NNS	Number=Plur	_	_	_	_
5	on	on	ADP	IN	_	_	_	_	_
6	I	I	PRON	PRP	Case=Nom|Number=Sing|Person=1|PronType=Prs	_	_	_	_
7	kappa	kappa	X	GW	_	_	_	_	_
8	B	b	X	GW	_	_	_	_	_
9	alpha	alpha	X	GW	_	_	_	_	_
10	result	result	NOUN	NN	Number=Sing	_	_	_	_
11	in	in	ADP	IN	_	_	_	_	_
12	nuclear	nuclear	ADJ	JJ	Degree=Pos	_	_	_	_
13	mobilization	mobilization	NOUN	NN	Number=Sing	_	_	_	_
14	of	of	ADP	IN	_	_	_	_	_
15	only	only	ADV	RB	_	_	_	_	_
16	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
17	fraction	fraction	NOUN	NN	Number=Sing	_	_	_	_
18	of	of	ADP	IN	_	_	_	_	_
19	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
20	entire	entire	ADJ	JJ	Degree=Pos	_	_	_	_
21	cytoplasmic	cytoplasmic	ADJ	JJ	Degree=Pos	_	_	_	_
22	pool	pool	NOUN	NN	Number=Sing	_	_	_	_
23	of	of	ADP	IN	_	_	_	_	_
24	RelA	RelA	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
25	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1591
# text = Subsequent studies have revealed that (i) cytoplasmic RelA is stably associated not only with I kappa B alpha but also with other ankyrin motif-rich proteins including the products of the NF-kappa B2 (p100) and NF-kappa B1 (p105) genes; (ii) in contrast to RelA-I kappa B alpha, RelA-p100 cytoplasmic complexes are not dissociated following tumor necrosis factor alpha activation; (iii) p100 functions as a potent inhibitor of RelA-mediated transcription in vivo; (iv) the interaction of RelA and p100 involves the conserved Rel homology domain of both proteins but not the nuclear localization signal of RelA, which is required for I kappa B alpha binding; (v) p100 inhibition of RelA function requires the C-terminal ankyrin motif domain, which mediates cytoplasmic retention of RelA; and (vi) as observed with I kappa B alpha, nuclear RelA stimulates p100 mRNA and protein expression.
1	Subsequent	subsequent	ADJ	JJ	Degree=Pos	_	_	_	_
2	studies	study	NOUN	NNS	Number=Plur	_	_	_	_
3	have	have	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
4	revealed	reveal	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
5	that	that	SCONJ	IN	_	_	_	_	_
6	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
7	i	i	PRON	PRP	Case=Nom|Number=Sing|Person=1|PronType=Prs	_	_	_	SpaceAfter=No
8	)	)	PUNCT	-RRB-	_	_	_	_	_
9	cytoplasmic	cytoplasmic	ADJ	JJ	Degree=Pos	_	_	_	_
10	RelA	Rela	NOUN	NN	Number=Sing	_	_	_	_
11	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
12	stably	stably	ADV	RB	_	_	_	_	_
13	associated	associate	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
14	not	not	ADV	RB	_	_	_	_	_
15	only	only	ADV	RB	_	_	_	_	_
16	with	with	SCONJ	IN	_	_	_	_	_
17	I	I	PRON	PRP	Case=Nom|Number=Sing|Person=1|PronType=Prs	_	_	_	_
18	kappa	kappa	PROPN	NNP	Number=Sing	_	_	_	_
19	B	b	PROPN	NNP	Number=Sing	_	_	_	_
20	alpha	alpha	NOUN	NN	Number=Sing	_	_	_	_
21	but	but	CCONJ	CC	_	_	_	_	_
22	also	also	ADV	RB	_	_	_	_	_
23	with	with	ADP	IN	_	_	_	_	_
24	other	other	ADJ	JJ	Degree=Pos	_	_	_	_
25	ankyrin	ankyrin	NOUN	NN	Number=Sing	_	_	_	_
26	motif	motif	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
27	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
28	rich	rich	ADJ	JJ	Degree=Pos	_	_	_	_
29	proteins	protein	NOUN	NNS	Number=Plur	_	_	_	_
30	including	include	VERB	VBG	VerbForm=Ger	_	_	_	_
31	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
32	products	product	NOUN	NNS	Number=Plur	_	_	_	_
33	of	of	ADP	IN	_	_	_	_	_
34	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
35	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
36	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
37	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_
38	B2	b2	NOUN	NN	Number=Sing	_	_	_	_
39	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
40	p100	p100	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
41	)	)	PUNCT	-RRB-	_	_	_	_	_
42	and	and	CCONJ	CC	_	_	_	_	_
43	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
44	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
45	kappa	kappa	PROPN	NNP	Number=Sing	_	_	_	_
46	B1	B1	PROPN	NNP	Number=Sing	_	_	_	_
47	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
48	p105	p105	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
49	)	)	PUNCT	-RRB-	_	_	_	_	_
50	genes	gene	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
51	;	;	PUNCT	,	_	_	_	_	_
52	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
53	ii	ii	X	LS	_	_	_	_	SpaceAfter=No
54	)	)	PUNCT	-RRB-	_	_	_	_	_
55	in	in	ADP	IN	_	_	_	_	_
56	contrast	contrast	NOUN	NN	Number=Sing	_	_	_	_
57	to	to	ADP	IN	_	_	_	_	_
58	RelA	RelA	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
59	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
60	I	I	PRON	PRP	Case=Nom|Number=Sing|Person=1|PronType=Prs	_	_	_	_
61	kappa	kappa	PROPN	NNP	Number=Sing	_	_	_	_
62	B	b	PROPN	NNP	Number=Sing	_	_	_	_
63	alpha	alpha	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
64	,	,	PUNCT	,	_	_	_	_	_
65	RelA	Rela	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
66	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
67	p100	p100	NUM	CD	NumType=Card	_	_	_	_
68	cytoplasmic	cytoplasmic	NOUN	NN	Number=Sing	_	_	_	_
69	complexes	complex	NOUN	NNS	Number=Plur	_	_	_	_
70	are	be	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
71	not	not	PART	RB	_	_	_	_	_
72	dissociated	dissociate	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
73	following	follow	VERB	VBG	VerbForm=Ger	_	_	_	_
74	tumor	tumor	NOUN	NN	Number=Sing	_	_	_	_
75	necrosis	necrosis	NOUN	NN	Number=Sing	_	_	_	_
76	factor	factor	NOUN	NN	Number=Sing	_	_	_	_
77	alpha	alpha	ADP	IN	_	_	_	_	_
78	activation	activation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
79	;	;	PUNCT	,	_	_	_	_	_
80	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
81	iii	iii	X	LS	_	_	_	_	SpaceAfter=No
82	)	)	PUNCT	-RRB-	_	_	_	_	_
83	p100	p100	NUM	CD	NumType=Card	_	_	_	_
84	functions	function	NOUN	NNS	Number=Plur	_	_	_	_
85	as	as	ADP	IN	_	_	_	_	_
86	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
87	potent	potent	NOUN	NN	Number=Sing	_	_	_	_
88	inhibitor	inhibitor	NOUN	NN	Number=Sing	_	_	_	_
89	of	of	ADP	IN	_	_	_	_	_
90	RelA	RelA	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
91	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
92	mediated	mediate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
93	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
94	in	in	ADP	IN	_	_	_	_	_
95	vivo	vivo	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
96	;	;	PUNCT	,	_	_	_	_	_
97	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
98	iv	iv	X	ADD	_	_	_	_	SpaceAfter=No
99	)	)	PUNCT	-RRB-	_	_	_	_	_
100	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
101	interaction	interaction	NOUN	NN	Number=Sing	_	_	_	_
102	of	of	ADP	IN	_	_	_	_	_
103	RelA	RelA	PROPN	NNP	Number=Sing	_	_	_	_
104	and	and	CCONJ	CC	_	_	_	_	_
105	p100	p100	NUM	CD	NumType=Card	_	_	_	_
106	involves	involf	NOUN	NNS	Number=Plur	_	_	_	_
107	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
108	conserved	conserve	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
109	Rel	Rel	NOUN	NN	Number=Sing	_	_	_	_
110	homology	homology	NOUN	NN	Number=Sing	_	_	_	_
111	domain	domain	NOUN	NN	Number=Sing	_	_	_	_
112	of	of	ADP	IN	_	_	_	_	_
113	both	both	DET	DT	_	_	_	_	_
114	proteins	protein	NOUN	NNS	Number=Plur	_	_	_	_
115	but	but	CCONJ	CC	_	_	_	_	_
116	not	not	PART	RB	_	_	_	_	_
117	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
118	nuclear	nuclear	ADJ	JJ	Degree=Pos	_	_	_	_
119	localization	localization	NOUN	NN	Number=Sing	_	_	_	_
120	signal	signal	NOUN	NN	Number=Sing	_	_	_	_
121	of	of	ADP	IN	_	_	_	_	_
122	RelA	RelA	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
123	,	,	PUNCT	,	_	_	_	_	_
124	which	which	PRON	WDT	PronType=Rel	_	_	_	_
125	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
126	required	require	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
127	for	for	SCONJ	IN	_	_	_	_	_
128	I	I	PRON	PRP	Case=Nom|Number=Sing|Person=1|PronType=Prs	_	_	_	_
129	kappa	kappa	X	GW	_	_	_	_	_
130	B	b	X	GW	_	_	_	_	_
131	alpha	alpha	X	GW	_	_	_	_	_
132	binding	binding	VERB	VBG	VerbForm=Ger	_	_	_	SpaceAfter=No
133	;	;	PUNCT	,	_	_	_	_	_
134	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
135	v	v	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
136	)	)	PUNCT	-RRB-	_	_	_	_	_
137	p100	p100	NUM	CD	NumType=Card	_	_	_	_
138	inhibition	inhibition	NOUN	NN	Number=Sing	_	_	_	_
139	of	of	ADP	IN	_	_	_	_	_
140	RelA	Rela	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
141	function	function	NOUN	NN	Number=Sing	_	_	_	_
142	requires	require	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
143	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
144	C-	c-	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
145	terminal	terminal	NOUN	NN	Number=Sing	_	_	_	_
146	ankyrin	ankyrin	ADP	IN	_	_	_	_	_
147	motif	motif	NOUN	NN	Number=Sing	_	_	_	_
148	domain	domain	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
149	,	,	PUNCT	,	_	_	_	_	_
150	which	which	PRON	WDT	PronType=Rel	_	_	_	_
151	mediates	mediate	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
152	cytoplasmic	cytoplasmic	ADJ	JJ	Degree=Pos	_	_	_	_
153	retention	retention	NOUN	NN	Number=Sing	_	_	_	_
154	of	of	ADP	IN	_	_	_	_	_
155	RelA	RelA	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
156	;	;	PUNCT	,	_	_	_	_	_
157	and	and	CCONJ	CC	_	_	_	_	_
158	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
159	vi	vi	X	LS	_	_	_	_	SpaceAfter=No
160	)	)	PUNCT	-RRB-	_	_	_	_	_
161	as	as	ADP	IN	_	_	_	_	_
162	observed	observed	ADJ	JJ	Degree=Pos	_	_	_	_
163	with	with	ADP	IN	_	_	_	_	_
164	I	I	PRON	PRP	Case=Nom|Number=Sing|Person=1|PronType=Prs	_	_	_	_
165	kappa	kappa	PROPN	NNP	Number=Sing	_	_	_	_
166	B	benefit	PROPN	NNP	Number=Sing	_	_	_	_
167	alpha	alpha	ADV	RB	_	_	_	_	SpaceAfter=No
168	,	,	PUNCT	,	_	_	_	_	_
169	nuclear	nuclear	ADJ	JJ	Degree=Pos	_	_	_	_
170	RelA	Rela	NOUN	NN	Number=Sing	_	_	_	_
171	stimulates	stimulate	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
172	p100	p100	NUM	CD	NumType=Card	_	_	_	_
173	mRNA	mRNa	NOUN	NN	Number=Sing	_	_	_	_
174	and	and	CCONJ	CC	_	_	_	_	_
175	protein	protein	NOUN	NN	Number=Sing	_	_	_	_
176	expression	expression	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
177	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1592
# text = These findings thus reveal the presence of a second inducible autoregulated inhibitory pathway that helps ensure the rapid but transient action of nuclear NF-kappa B.
1	These	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
2	findings	finding	NOUN	NNS	Number=Plur	_	_	_	_
3	thus	thus	ADV	RB	_	_	_	_	_
4	reveal	reveal	VERB	VB	VerbForm=Inf	_	_	_	_
5	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
6	presence	presence	NOUN	NN	Number=Sing	_	_	_	_
7	of	of	ADP	IN	_	_	_	_	_
8	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
9	second	second	ADJ	JJ	Degree=Pos|NumType=Ord	_	_	_	_
10	inducible	inducible	ADJ	JJ	Degree=Pos	_	_	_	_
11	autoregulated	autoregulate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
12	inhibitory	inhibitory	ADJ	JJ	Degree=Pos	_	_	_	_
13	pathway	pathway	NOUN	NN	Number=Sing	_	_	_	_
14	that	that	PRON	WDT	PronType=Rel	_	_	_	_
15	helps	help	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
16	ensure	ensure	VERB	VB	VerbForm=Inf	_	_	_	_
17	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
18	rapid	rapid	ADJ	JJ	Degree=Pos	_	_	_	_
19	but	but	CCONJ	CC	_	_	_	_	_
20	transient	transient	ADJ	JJ	Degree=Pos	_	_	_	_
21	action	action	NOUN	NN	Number=Sing	_	_	_	_
22	of	of	ADP	IN	_	_	_	_	_
23	nuclear	nuclear	ADJ	JJ	Degree=Pos	_	_	_	_
24	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
25	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
26	kappa	kappa	PROPN	NNP	Number=Sing	_	_	_	_
27	B.	B.	PROPN	NNP	Number=Sing	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 1593
# text = Document 003002582 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	003002582	003002582	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 1594
# text = Functional interaction between the two zinc finger domains of the v-erb A oncoprotein.
1	Functional	functional	ADJ	JJ	Degree=Pos	_	_	_	_
2	interaction	interaction	NOUN	NN	Number=Sing	_	_	_	_
3	between	between	ADP	IN	_	_	_	_	_
4	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
5	two	two	NUM	CD	NumType=Card	_	_	_	_
6	zinc	zinc	NOUN	NN	Number=Sing	_	_	_	_
7	finger	finger	NOUN	NN	Number=Sing	_	_	_	_
8	domains	domain	NOUN	NNS	Number=Plur	_	_	_	_
9	of	of	ADP	IN	_	_	_	_	_
10	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
11	v-	v-	SYM	NFP	_	_	_	_	SpaceAfter=No
12	erb	erb	VERB	VB	Mood=Imp|VerbForm=Fin	_	_	_	_
13	A	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
14	oncoprotein	oncoprotein	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
15	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 1595
# text = The v-erb
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	v-	v-	SYM	NFP	_	_	_	_	SpaceAfter=No
3	erb	erb	NOUN	NN	Number=Sing	_	_	_	_

# sent_id = 1596
# text = A oncogene of avian erythroblastosis virus is a mutated and virally transduced copy of a host cell gene encoding a thyroid hormone receptor.
1	A	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
2	oncogene	oncogene	NOUN	NN	Number=Sing	_	_	_	_
3	of	of	ADP	IN	_	_	_	_	_
4	avian	avian	ADJ	JJ	Degree=Pos	_	_	_	_
5	erythroblastosis	erythroblastosis	NOUN	NN	Number=Sing	_	_	_	_
6	virus	virus	NOUN	NN	Number=Sing	_	_	_	_
7	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
8	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
9	mutated	mutate	ADJ	JJ	Degree=Pos	_	_	_	_
10	and	and	CCONJ	CC	_	_	_	_	_
11	virally	virally	ADV	RB	_	_	_	_	_
12	transduced	transduce	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
13	copy	copy	NOUN	NN	Number=Sing	_	_	_	_
14	of	of	ADP	IN	_	_	_	_	_
15	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
16	host	host	NOUN	NN	Number=Sing	_	_	_	_
17	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
18	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
19	encoding	encod	VERB	VBG	VerbForm=Ger	_	_	_	_
20	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
21	thyroid	thyroid	NOUN	NN	Number=Sing	_	_	_	_
22	hormone	hormone	NOUN	NN	Number=Sing	_	_	_	_
23	receptor	receptor	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
24	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1597
# text = The protein expressed by the v-erb A oncogene binds to DNA and acts as a dominant negative inhibitor of both the thyroid hormone receptor and the closely related retinoic acid receptor.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	protein	protein	NOUN	NN	Number=Sing	_	_	_	_
3	expressed	express	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
4	by	by	ADP	IN	_	_	_	_	_
5	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
6	v-	v-	SYM	NFP	_	_	_	_	SpaceAfter=No
7	erb	erb	ADJ	JJ	Degree=Pos	_	_	_	_
8	A	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
9	oncogene	oncogene	ADJ	JJ	Degree=Pos	_	_	_	_
10	binds	bind	NOUN	NNS	Number=Plur	_	_	_	_
11	to	to	ADP	IN	_	_	_	_	_
12	DNA	Dna	NOUN	NN	Number=Sing	_	_	_	_
13	and	and	CCONJ	CC	_	_	_	_	_
14	acts	act	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
15	as	as	ADP	IN	_	_	_	_	_
16	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
17	dominant	dominant	ADJ	JJ	Degree=Pos	_	_	_	_
18	negative	negative	ADJ	JJ	Degree=Pos	_	_	_	_
19	inhibitor	inhibitor	NOUN	NN	Number=Sing	_	_	_	_
20	of	of	ADP	IN	_	_	_	_	_
21	both	both	CCONJ	CC	_	_	_	_	_
22	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
23	thyroid	thyroid	NOUN	NN	Number=Sing	_	_	_	_
24	hormone	hormone	NOUN	NN	Number=Sing	_	_	_	_
25	receptor	receptor	NOUN	NN	Number=Sing	_	_	_	_
26	and	and	CCONJ	CC	_	_	_	_	_
27	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
28	closely	closely	ADV	RB	_	_	_	_	_
29	related	related	ADJ	JJ	Degree=Pos	_	_	_	_
30	retinoic	retinoic	ADJ	JJ	Degree=Pos	_	_	_	_
31	acid	acid	ADJ	JJ	Degree=Pos	_	_	_	_
32	receptor	receptor	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
33	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1598
# text = The v-erb
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	v-	v-	SYM	NFP	_	_	_	_	SpaceAfter=No
3	erb	erb	NOUN	NN	Number=Sing	_	_	_	_

# sent_id = 1599
# text = A protein has sustained two amino acid alterations within its DNA-binding domain relative to that of c-erb A, one of which, at serine 61, is known to be important for v-erb A function in the neoplastic cell.
1	A	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
2	protein	protein	NOUN	NN	Number=Sing	_	_	_	_
3	has	have	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
4	sustained	sustain	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
5	two	two	NUM	CD	NumType=Card	_	_	_	_
6	amino	amino	DET	DT	_	_	_	_	_
7	acid	acid	ADJ	JJ	Degree=Pos	_	_	_	_
8	alterations	alteration	NOUN	NNS	Number=Plur	_	_	_	_
9	within	within	ADP	IN	_	_	_	_	_
10	its	its	PRON	PRP$	Gender=Neut|Number=Sing|Person=3|Poss=Yes|PronType=Prs	_	_	_	_
11	DNA	dna	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
12	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
13	binding	binding	VERB	VBG	VerbForm=Ger	_	_	_	_
14	domain	domain	NOUN	NN	Number=Sing	_	_	_	_
15	relative	relative	ADV	RB	_	_	_	_	_
16	to	to	ADP	IN	_	_	_	_	_
17	that	that	PRON	DT	Number=Sing|PronType=Dem	_	_	_	_
18	of	of	ADP	IN	_	_	_	_	_
19	c-	c-	SYM	NFP	_	_	_	_	SpaceAfter=No
20	erb	erb	NOUN	NN	Number=Sing	_	_	_	_
21	A	a	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
22	,	,	PUNCT	,	_	_	_	_	_
23	one	one	NUM	CD	NumType=Card	_	_	_	_
24	of	of	ADP	IN	_	_	_	_	_
25	which	which	PRON	WDT	PronType=Int	_	_	_	SpaceAfter=No
26	,	,	PUNCT	,	_	_	_	_	_
27	at	at	ADP	IN	_	_	_	_	_
28	serine	serine	NOUN	NN	Number=Sing	_	_	_	_
29	61	61	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
30	,	,	PUNCT	,	_	_	_	_	_
31	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
32	known	know	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
33	to	to	PART	TO	_	_	_	_	_
34	be	be	AUX	VB	VerbForm=Inf	_	_	_	_
35	important	important	ADJ	JJ	Degree=Pos	_	_	_	_
36	for	for	ADP	IN	_	_	_	_	_
37	v-	v-	SYM	NFP	_	_	_	_	SpaceAfter=No
38	erb	erb	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
39	A	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
40	function	function	NOUN	NN	Number=Sing	_	_	_	_
41	in	in	ADP	IN	_	_	_	_	_
42	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
43	neoplastic	neoplastic	ADJ	JJ	Degree=Pos	_	_	_	_
44	cell	cell	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
45	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1600
# text = We report here that the second alteration, at threonine 78, also plays an important, although more indirect, role: alteration of the sequence at threonine 78 such that it resembles that of c-erb
1	We	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
2	report	report	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
3	here	here	ADV	RB	PronType=Dem	_	_	_	_
4	that	that	SCONJ	IN	_	_	_	_	_
5	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
6	second	second	ADJ	JJ	Degree=Pos|NumType=Ord	_	_	_	_
7	alteration	alteration	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
8	,	,	PUNCT	,	_	_	_	_	_
9	at	at	ADP	IN	_	_	_	_	_
10	threonine	threonine	NUM	CD	NumType=Card	_	_	_	_
11	78	78	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
12	,	,	PUNCT	,	_	_	_	_	_
13	also	also	ADV	RB	_	_	_	_	_
14	plays	play	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
15	an	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
16	important	important	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
17	,	,	PUNCT	,	_	_	_	_	_
18	although	although	SCONJ	IN	_	_	_	_	_
19	more	more	ADJ	JJR	Degree=Cmp	_	_	_	_
20	indirect	indirect	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
21	,	,	PUNCT	,	_	_	_	_	_
22	role	role	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
23	:	:	PUNCT	:	_	_	_	_	_
24	alteration	alteration	NOUN	NN	Number=Sing	_	_	_	_
25	of	of	ADP	IN	_	_	_	_	_
26	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
27	sequence	sequence	NOUN	NN	Number=Sing	_	_	_	_
28	at	at	ADP	IN	_	_	_	_	_
29	threonine	threonine	NUM	CD	NumType=Card	_	_	_	_
30	78	78	NUM	CD	NumType=Card	_	_	_	_
31	such	such	ADJ	JJ	Degree=Pos	_	_	_	_
32	that	that	SCONJ	IN	_	_	_	_	_
33	it	it	PRON	PRP	Case=Nom|Gender=Neut|Number=Sing|Person=3|PronType=Prs	_	_	_	_
34	resembles	resemble	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
35	that	that	PRON	DT	Number=Sing|PronType=Dem	_	_	_	_
36	of	of	ADP	IN	_	_	_	_	_
37	c-	c-	SYM	NFP	_	_	_	_	SpaceAfter=No
38	erb	erb	NOUN	NN	Number=Sing	_	_	_	_

# sent_id = 1601
# text = A can act as an intragenic suppressor and can partially restore function to a v-erb
1	A	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
2	can	can	AUX	MD	VerbForm=Fin	_	_	_	_
3	act	act	VERB	VB	VerbForm=Inf	_	_	_	_
4	as	as	ADP	IN	_	_	_	_	_
5	an	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
6	intragenic	intragenic	ADJ	JJ	Degree=Pos	_	_	_	_
7	suppressor	suppressor	NOUN	NN	Number=Sing	_	_	_	_
8	and	and	CCONJ	CC	_	_	_	_	_
9	can	can	AUX	MD	VerbForm=Fin	_	_	_	_
10	partially	partially	ADV	RB	_	_	_	_	_
11	restore	restore	VERB	VB	VerbForm=Inf	_	_	_	_
12	function	function	NOUN	NN	Number=Sing	_	_	_	_
13	to	to	ADP	IN	_	_	_	_	_
14	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
15	v-	v-	SYM	NFP	_	_	_	_	SpaceAfter=No
16	erb	erb	NOUN	NN	Number=Sing	_	_	_	_

# sent_id = 1602
# text = A protein rendered defective due to a mutation at position 61.
1	A	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
2	protein	protein	NOUN	NN	Number=Sing	_	_	_	_
3	rendered	render	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
4	defective	defective	ADJ	JJ	Degree=Pos	_	_	_	_
5	due	due	ADP	IN	_	_	_	_	_
6	to	to	ADP	IN	_	_	_	_	_
7	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
8	mutation	mutation	NOUN	NN	Number=Sing	_	_	_	_
9	at	at	ADP	IN	_	_	_	_	_
10	position	position	NOUN	NN	Number=Sing	_	_	_	_
11	61	61	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
12	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1603
# text = Threonine 78 lies within the D-box of the v-erb A protein, a region thought to mediate receptor-receptor dimerizations, and is not in physical proximity to the serine at position 61.
1	Threonine	Threonine	NUM	CD	NumType=Card	_	_	_	_
2	78	78	NUM	CD	NumType=Card	_	_	_	_
3	lies	lie	NOUN	NNS	Number=Plur	_	_	_	_
4	within	within	ADP	IN	_	_	_	_	_
5	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
6	D-	d-	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
7	box	box	NOUN	NN	Number=Sing	_	_	_	_
8	of	of	ADP	IN	_	_	_	_	_
9	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
10	v-	v-	SYM	NFP	_	_	_	_	SpaceAfter=No
11	erb	erb	VERB	VB	Mood=Imp|VerbForm=Fin	_	_	_	_
12	A	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
13	protein	protein	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
14	,	,	PUNCT	,	_	_	_	_	_
15	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
16	region	region	NOUN	NN	Number=Sing	_	_	_	_
17	thought	think	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
18	to	to	PART	TO	_	_	_	_	_
19	mediate	mediate	VERB	VB	VerbForm=Inf	_	_	_	_
20	receptor	receptor	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
21	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
22	receptor	receptor	NOUN	NN	Number=Sing	_	_	_	_
23	dimerizations	dimerization	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
24	,	,	PUNCT	,	_	_	_	_	_
25	and	and	CCONJ	CC	_	_	_	_	_
26	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
27	not	not	PART	RB	_	_	_	_	_
28	in	in	ADP	IN	_	_	_	_	_
29	physical	physical	ADJ	JJ	Degree=Pos	_	_	_	_
30	proximity	proximity	NOUN	NN	Number=Sing	_	_	_	_
31	to	to	ADP	IN	_	_	_	_	_
32	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
33	serine	serine	NOUN	NN	Number=Sing	_	_	_	_
34	at	at	ADP	IN	_	_	_	_	_
35	position	position	NOUN	NN	Number=Sing	_	_	_	_
36	61	61	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
37	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1604
# text = It therefore appears that an indirect interaction occurs between these two sites and that this interaction is crucial for v-erb
1	It	it	PRON	PRP	Case=Nom|Gender=Neut|Number=Sing|Person=3|PronType=Prs	_	_	_	_
2	therefore	therefore	ADV	RB	_	_	_	_	_
3	appears	appear	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
4	that	that	PRON	DT	Number=Sing|PronType=Dem	_	_	_	_
5	an	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
6	indirect	indirect	ADJ	JJ	Degree=Pos	_	_	_	_
7	interaction	interaction	NOUN	NN	Number=Sing	_	_	_	_
8	occurs	occur	NOUN	NNS	Number=Plur	_	_	_	_
9	between	between	ADP	IN	_	_	_	_	_
10	these	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
11	two	two	NUM	CD	NumType=Card	_	_	_	_
12	sites	site	NOUN	NNS	Number=Plur	_	_	_	_
13	and	and	CCONJ	CC	_	_	_	_	_
14	that	that	SCONJ	IN	_	_	_	_	_
15	this	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
16	interaction	interaction	NOUN	NN	Number=Sing	_	_	_	_
17	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
18	crucial	crucial	ADJ	JJ	Degree=Pos	_	_	_	_
19	for	for	ADP	IN	_	_	_	_	_
20	v-	v-	SYM	NFP	_	_	_	_	SpaceAfter=No
21	erb	erb	NOUN	NN	Number=Sing	_	_	_	_

# sent_id = 1605
# text = A function.
1	A	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
2	function	function	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
3	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 1606
# text = Document 003002583 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	003002583	003002583	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 1607
# text = Abnormal T lymphocyte development induced by targeted overexpression of IkappaB alpha.
1	Abnormal	abnormal	PROPN	NNP	Number=Sing	_	_	_	_
2	T	T	PROPN	NNP	Number=Sing	_	_	_	_
3	lymphocyte	lymphocyte	NOUN	NN	Number=Sing	_	_	_	_
4	development	development	NOUN	NN	Number=Sing	_	_	_	_
5	induced	induce	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
6	by	by	ADP	IN	_	_	_	_	_
7	targeted	target	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
8	overexpression	overexpression	NOUN	NN	Number=Sing	_	_	_	_
9	of	of	ADP	IN	_	_	_	_	_
10	IkappaB	IkappaB	PROPN	NNP	Number=Sing	_	_	_	_
11	alpha	alpha	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
12	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 1608
# text = A role in thymic maturation for factors of the NF-kappaB family has long been suspected, but not yet proven.
1	A	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
2	role	role	NOUN	NN	Number=Sing	_	_	_	_
3	in	in	ADP	IN	_	_	_	_	_
4	thymic	thymic	ADJ	JJ	Degree=Pos	_	_	_	_
5	maturation	maturation	NOUN	NN	Number=Sing	_	_	_	_
6	for	for	ADP	IN	_	_	_	_	_
7	factors	factor	NOUN	NNS	Number=Plur	_	_	_	_
8	of	of	ADP	IN	_	_	_	_	_
9	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
10	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
11	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
12	kappaB	kappaB	PROPN	NNP	Number=Sing	_	_	_	_
13	family	family	NOUN	NN	Number=Sing	_	_	_	_
14	has	have	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
15	long	long	ADV	RB	Degree=Pos	_	_	_	_
16	been	be	AUX	VBN	Tense=Past|VerbForm=Part	_	_	_	_
17	suspected	suspect	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	SpaceAfter=No
18	,	,	PUNCT	,	_	_	_	_	_
19	but	but	CCONJ	CC	_	_	_	_	_
20	not	not	PART	RB	_	_	_	_	_
21	yet	yet	ADV	RB	_	_	_	_	_
22	proven	prove	VERB	VB	VerbForm=Inf	_	_	_	SpaceAfter=No
23	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1609
# text = Transgenic mice with a lymphocyte-specific defect in NF-kappaB activation were produced by targeted expression of human IkappaB alpha.
1	Transgenic	Transgenic	ADJ	JJ	Degree=Pos	_	_	_	_
2	mice	mouse	NOUN	NNS	Number=Plur	_	_	_	_
3	with	with	ADP	IN	_	_	_	_	_
4	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
5	lymphocyte	lymphocyte	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
6	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
7	specific	specific	ADJ	JJ	Degree=Pos	_	_	_	_
8	defect	defect	NOUN	NN	Number=Sing	_	_	_	_
9	in	in	ADP	IN	_	_	_	_	_
10	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
11	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
12	kappaB	kappaB	PROPN	NNP	Number=Sing	_	_	_	_
13	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
14	were	be	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
15	produced	produce	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
16	by	by	ADP	IN	_	_	_	_	_
17	targeted	target	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
18	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
19	of	of	ADP	IN	_	_	_	_	_
20	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
21	IkappaB	IkappaB	PROPN	NNP	Number=Sing	_	_	_	_
22	alpha	alpha	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
23	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1610
# text = The thymic cellularity of these mice was significantly decreased.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	thymic	thymic	ADJ	JJ	Degree=Pos	_	_	_	_
3	cellularity	cellularity	NOUN	NN	Number=Sing	_	_	_	_
4	of	of	ADP	IN	_	_	_	_	_
5	these	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
6	mice	mouse	NOUN	NNS	Number=Plur	_	_	_	_
7	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
8	significantly	significantly	ADV	RB	_	_	_	_	_
9	decreased	decrease	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	SpaceAfter=No
10	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1611
# text = The proportion of mature, TCRhigh thymocytes of the alphabeta lineage was reduced, and the remaining TCRhigh population contained an unusually high proportion of double-positive cells.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	proportion	proportion	NOUN	NN	Number=Sing	_	_	_	_
3	of	of	ADP	IN	_	_	_	_	_
4	mature	mature	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
5	,	,	PUNCT	,	_	_	_	_	_
6	TC	tc	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
7	Rhigh	Rhigh	PROPN	NNP	Number=Sing	_	_	_	_
8	thymocytes	thymocyte	NOUN	NNS	Number=Plur	_	_	_	_
9	of	of	ADP	IN	_	_	_	_	_
10	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
11	alphabeta	alphabeta	NOUN	NN	Number=Sing	_	_	_	_
12	lineage	lineage	NOUN	NN	Number=Sing	_	_	_	_
13	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
14	reduced	reduce	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	SpaceAfter=No
15	,	,	PUNCT	,	_	_	_	_	_
16	and	and	CCONJ	CC	_	_	_	_	_
17	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
18	remaining	remain	VERB	VBG	VerbForm=Ger	_	_	_	_
19	TC	tc	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
20	Rhigh	Rhigh	PROPN	NNP	Number=Sing	_	_	_	_
21	population	population	NOUN	NN	Number=Sing	_	_	_	_
22	contained	contain	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
23	an	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
24	unusually	unusually	ADV	RB	_	_	_	_	_
25	high	high	ADJ	JJ	Degree=Pos	_	_	_	_
26	proportion	proportion	NOUN	NN	Number=Sing	_	_	_	_
27	of	of	ADP	IN	_	_	_	_	_
28	double	double	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
29	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
30	positive	positive	ADJ	JJ	Degree=Pos	_	_	_	_
31	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
32	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1612
# text = This defect in maturation resulted in a transgene dose-dependent reduction in peripheral T lymphocytes, with the CD8 lineage being more severely affected.
1	This	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
2	defect	defect	NOUN	NN	Number=Sing	_	_	_	_
3	in	in	ADP	IN	_	_	_	_	_
4	maturation	maturation	NOUN	NN	Number=Sing	_	_	_	_
5	resulted	result	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
6	in	in	ADP	IN	_	_	_	_	_
7	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
8	transgene	transgene	NOUN	NN	Number=Sing	_	_	_	_
9	dose	dose	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
10	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
11	dependent	dependent	ADJ	JJ	Degree=Pos	_	_	_	_
12	reduction	reduction	NOUN	NN	Number=Sing	_	_	_	_
13	in	in	ADP	IN	_	_	_	_	_
14	peripheral	peripheral	ADJ	JJ	Degree=Pos	_	_	_	_
15	T	t	PROPN	NNP	Number=Sing	_	_	_	_
16	lymphocytes	lymphocyte	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
17	,	,	PUNCT	,	_	_	_	_	_
18	with	with	ADP	IN	_	_	_	_	_
19	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
20	CD8	Cd8	NOUN	NN	Number=Sing	_	_	_	_
21	lineage	lineage	NOUN	NN	Number=Sing	_	_	_	_
22	being	be	AUX	VBG	VerbForm=Ger	_	_	_	_
23	more	more	ADV	RBR	_	_	_	_	_
24	severely	severely	ADV	RB	_	_	_	_	_
25	affected	affect	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	SpaceAfter=No
26	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1613
# text = These data provide direct evidence for the involvement of NF-kappaB/Rel family proteins in late stages of T lymphocyte development, coincident with positive and negative selection.
1	These	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
2	data	data	NOUN	NN	Number=Sing	_	_	_	_
3	provide	provide	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
4	direct	direct	ADJ	JJ	Degree=Pos	_	_	_	_
5	evidence	evidence	NOUN	NN	Number=Sing	_	_	_	_
6	for	for	ADP	IN	_	_	_	_	_
7	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
8	involvement	involvement	NOUN	NN	Number=Sing	_	_	_	_
9	of	of	ADP	IN	_	_	_	_	_
10	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
11	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
12	kappaB	kappaB	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
13	/	/	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
14	Rel	Rel	PROPN	NNP	Number=Sing	_	_	_	_
15	family	family	NOUN	NN	Number=Sing	_	_	_	_
16	proteins	protein	NOUN	NNS	Number=Plur	_	_	_	_
17	in	in	ADP	IN	_	_	_	_	_
18	late	late	ADJ	JJ	Degree=Pos	_	_	_	_
19	stages	stage	NOUN	NNS	Number=Plur	_	_	_	_
20	of	of	ADP	IN	_	_	_	_	_
21	T	t	PROPN	NNP	Number=Sing	_	_	_	_
22	lymphocyte	lymphocyte	NOUN	NN	Number=Sing	_	_	_	_
23	development	development	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
24	,	,	PUNCT	,	_	_	_	_	_
25	coincident	coincident	NOUN	NN	Number=Sing	_	_	_	_
26	with	with	ADP	IN	_	_	_	_	_
27	positive	positive	ADJ	JJ	Degree=Pos	_	_	_	_
28	and	and	CCONJ	CC	_	_	_	_	_
29	negative	negative	ADJ	JJ	Degree=Pos	_	_	_	_
30	selection	selection	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
31	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 1614
# text = Document 003002587 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	003002587	003002587	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 1615
# text = Inhibition of transcription factors belonging to the rel/NF-kappa B family by a transdominant negative mutant.
1	Inhibition	Inhibition	NOUN	NN	Number=Sing	_	_	_	_
2	of	of	ADP	IN	_	_	_	_	_
3	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
4	factors	factor	NOUN	NNS	Number=Plur	_	_	_	_
5	belonging	belong	VERB	VBG	VerbForm=Ger	_	_	_	_
6	to	to	ADP	IN	_	_	_	_	_
7	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
8	rel/	relith	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
9	NF	NF	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
10	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
11	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_
12	B	b	NOUN	NN	Number=Sing	_	_	_	_
13	family	family	NOUN	NN	Number=Sing	_	_	_	_
14	by	by	ADP	IN	_	_	_	_	_
15	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
16	transdominant	transdominant	ADJ	JJ	Degree=Pos	_	_	_	_
17	negative	negative	ADJ	JJ	Degree=Pos	_	_	_	_
18	mutant	mutant	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
19	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 1616
# text = The KBF1 factor, which binds to the enhancer
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	KBF1	KBF1	PROPN	NNP	Number=Sing	_	_	_	_
3	factor	factor	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
4	,	,	PUNCT	,	_	_	_	_	_
5	which	which	PRON	WDT	PronType=Rel	_	_	_	_
6	binds	bind	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
7	to	to	ADP	IN	_	_	_	_	_
8	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
9	enhancer	enhancer	NOUN	NN	Number=Sing	_	_	_	_

# sent_id = 1617
# text = A located in the promoter of the mouse MHC class I gene H-2Kb, is indistinguishable from the p50 DNA binding subunit of the transcription factor NF-kappa B, which regulates a series of genes involved in immune and inflammatory responses.
1	A	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
2	located	locate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
3	in	in	ADP	IN	_	_	_	_	_
4	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
5	promoter	promoter	NOUN	NN	Number=Sing	_	_	_	_
6	of	of	ADP	IN	_	_	_	_	_
7	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
8	mouse	mouse	NOUN	NN	Number=Sing	_	_	_	_
9	MHC	MHC	PROPN	NNP	Number=Sing	_	_	_	_
10	class	class	NOUN	NN	Number=Sing	_	_	_	_
11	I	I	PRON	PRP	Case=Nom|Number=Sing|Person=1|PronType=Prs	_	_	_	_
12	gene	gene	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
13	H	h	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
14	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
15	2	2	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
16	Kb	kb	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
17	,	,	PUNCT	,	_	_	_	_	_
18	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
19	indistinguishable	indistinguishable	ADJ	JJ	Degree=Pos	_	_	_	_
20	from	from	ADP	IN	_	_	_	_	_
21	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
22	p50	p50	NOUN	NN	Number=Sing	_	_	_	_
23	DNA	dna	NOUN	NN	Number=Sing	_	_	_	_
24	binding	binde	VERB	VBG	VerbForm=Ger	_	_	_	_
25	subunit	subunit	NOUN	NN	Number=Sing	_	_	_	_
26	of	of	ADP	IN	_	_	_	_	_
27	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
28	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
29	factor	factor	NOUN	NN	Number=Sing	_	_	_	_
30	NF	Nf	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
31	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
32	kappa	kappa	PROPN	NNP	Number=Sing	_	_	_	_
33	B	b	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
34	,	,	PUNCT	,	_	_	_	_	_
35	which	which	PRON	WDT	PronType=Rel	_	_	_	_
36	regulates	regulate	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
37	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
38	series	series	NOUN	NN	Number=Sing	_	_	_	_
39	of	of	ADP	IN	_	_	_	_	_
40	genes	gene	NOUN	NNS	Number=Plur	_	_	_	_
41	involved	involved	ADJ	JJ	Degree=Pos	_	_	_	_
42	in	in	ADP	IN	_	_	_	_	_
43	immune	immune	ADJ	JJ	Degree=Pos	_	_	_	_
44	and	and	CCONJ	CC	_	_	_	_	_
45	inflammatory	inflammatory	ADJ	JJ	Degree=Pos	_	_	_	_
46	responses	response	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
47	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1618
# text = The KBF1/p50 factor binds as a homodimer but can also form heterodimers with the products of other members of the same family, like the c-rel and v-rel (proto)oncogenes.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	KBF1/p50	KBF1/p50	PROPN	NNP	Number=Sing	_	_	_	_
3	factor	factor	NOUN	NN	Number=Sing	_	_	_	_
4	binds	bind	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
5	as	as	ADP	IN	_	_	_	_	_
6	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
7	homodimer	homodimer	NOUN	NN	Number=Sing	_	_	_	_
8	but	but	CCONJ	CC	_	_	_	_	_
9	can	can	AUX	MD	VerbForm=Fin	_	_	_	_
10	also	also	ADV	RB	_	_	_	_	_
11	form	form	VERB	VB	VerbForm=Inf	_	_	_	_
12	heterodimers	heterodimer	NOUN	NNS	Number=Plur	_	_	_	_
13	with	with	ADP	IN	_	_	_	_	_
14	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
15	products	product	NOUN	NNS	Number=Plur	_	_	_	_
16	of	of	ADP	IN	_	_	_	_	_
17	other	other	ADJ	JJ	Degree=Pos	_	_	_	_
18	members	member	NOUN	NNS	Number=Plur	_	_	_	_
19	of	of	ADP	IN	_	_	_	_	_
20	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
21	same	same	ADJ	JJ	Degree=Pos	_	_	_	_
22	family	family	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
23	,	,	PUNCT	,	_	_	_	_	_
24	like	like	ADP	IN	_	_	_	_	_
25	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
26	c-	c-	SYM	NFP	_	_	_	_	SpaceAfter=No
27	rel	rel	NOUN	NN	Number=Sing	_	_	_	_
28	and	and	CCONJ	CC	_	_	_	_	_
29	v-rel	v-rel	NOUN	NN	Number=Sing	_	_	_	_
30	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
31	proto	proto	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
32	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
33	oncogenes	oncogene	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
34	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1619
# text = The dimerization domain of KBF1/p50 is contained between amino acids 201 and 367.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	dimerization	dimerization	NOUN	NN	Number=Sing	_	_	_	_
3	domain	domain	NOUN	NN	Number=Sing	_	_	_	_
4	of	of	ADP	IN	_	_	_	_	_
5	KBF	KBF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
6	1	1	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
7	/	/	PUNCT	,	_	_	_	_	SpaceAfter=No
8	p50	p50	NOUN	NN	Number=Sing	_	_	_	_
9	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
10	contained	contain	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
11	between	between	ADP	IN	_	_	_	_	_
12	amino	amino	DET	DT	_	_	_	_	_
13	acids	acid	NOUN	NNS	Number=Plur	_	_	_	_
14	201	201	NUM	CD	NumType=Card	_	_	_	_
15	and	and	CCONJ	CC	_	_	_	_	_
16	367	367	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
17	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1620
# text = A mutant of KBF1/p50 (delta SP), unable to bind to DNA but able to form homo- or heterodimers, has been constructed.
1	A	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
2	mutant	mutant	NOUN	NN	Number=Sing	_	_	_	_
3	of	of	ADP	IN	_	_	_	_	_
4	KBF1/	Kbf1/	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
5	p50	p50	NUM	CD	NumType=Card	_	_	_	_
6	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
7	delta	delta	NOUN	NN	Number=Sing	_	_	_	_
8	SP	sp	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
9	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
10	,	,	PUNCT	,	_	_	_	_	_
11	unable	unable	ADJ	JJ	Degree=Pos	_	_	_	_
12	to	to	PART	TO	_	_	_	_	_
13	bind	bind	VERB	VB	VerbForm=Inf	_	_	_	_
14	to	to	ADP	IN	_	_	_	_	_
15	DNA	dna	NOUN	NN	Number=Sing	_	_	_	_
16	but	but	CCONJ	CC	_	_	_	_	_
17	able	able	ADJ	JJ	Degree=Pos	_	_	_	_
18	to	to	PART	TO	_	_	_	_	_
19	form	form	VERB	VB	VerbForm=Inf	_	_	_	_
20	homo	homo	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
21	-	-	PUNCT	HYPH	_	_	_	_	_
22	or	or	CCONJ	CC	_	_	_	_	_
23	heterodimers	heterodimer	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
24	,	,	PUNCT	,	_	_	_	_	_
25	has	have	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
26	been	be	AUX	VBN	Tense=Past|VerbForm=Part	_	_	_	_
27	constructed	construct	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	SpaceAfter=No
28	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1621
# text = This protein reduces or abolishes in vitro the DNA binding activity of wild-type proteins of the same family (KBF1/p50, c- and v-rel).
1	This	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
2	protein	protein	NOUN	NN	Number=Sing	_	_	_	_
3	reduces	reduce	NOUN	NNS	Number=Plur	_	_	_	_
4	or	or	CCONJ	CC	_	_	_	_	_
5	abolishes	abolish	NOUN	NNS	Number=Plur	_	_	_	_
6	in	in	ADP	IN	_	_	_	_	_
7	vitro	vitro	ADP	IN	Typo=Yes	_	_	_	_
8	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
9	DNA	dna	NOUN	NN	Number=Sing	_	_	_	_
10	binding	bind	VERB	VBG	VerbForm=Ger	_	_	_	_
11	activity	activity	NOUN	NN	Number=Sing	_	_	_	_
12	of	of	ADP	IN	_	_	_	_	_
13	wild	wild	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
14	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
15	type	type	NOUN	NN	Number=Sing	_	_	_	_
16	proteins	protein	NOUN	NNS	Number=Plur	_	_	_	_
17	of	of	ADP	IN	_	_	_	_	_
18	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
19	same	same	ADJ	JJ	Degree=Pos	_	_	_	_
20	family	family	NOUN	NN	Number=Sing	_	_	_	_
21	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
22	KBF	KBF	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
23	1/	1/	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
24	p50	p50	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
25	,	,	PUNCT	,	_	_	_	_	_
26	c	c	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
27	-	-	PUNCT	,	_	_	_	_	_
28	and	and	CCONJ	CC	_	_	_	_	_
29	v-rel	v-rel	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
30	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
31	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1622
# text = This mutant also functions in vivo as a trans-acting dominant negative regulator: the transcriptional inducibility of the HIV long terminal repeat (which contains two potential NF-kappa B binding sites) by phorbol ester (PMA) is inhibited when it is co-transfected into CD4+ T cells with the delta SP mutant.
1	This	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
2	mutant	mutant	NOUN	NN	Number=Sing	_	_	_	_
3	also	also	ADV	RB	_	_	_	_	_
4	functions	function	NOUN	NNS	Number=Plur	_	_	_	_
5	in	in	ADP	IN	_	_	_	_	_
6	vivo	vivo	NOUN	NN	Number=Sing	_	_	_	_
7	as	as	ADP	IN	_	_	_	_	_
8	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
9	trans	tran	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
10	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
11	acting	act	VERB	VBG	VerbForm=Ger	_	_	_	_
12	dominant	dominant	ADJ	JJ	Degree=Pos	_	_	_	_
13	negative	negative	NOUN	NN	Number=Sing	_	_	_	_
14	regulator	regulator	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
15	:	:	PUNCT	:	_	_	_	_	_
16	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
17	transcriptional	transcriptional	ADJ	JJ	Degree=Pos	_	_	_	_
18	inducibility	inducibility	NOUN	NN	Number=Sing	_	_	_	_
19	of	of	ADP	IN	_	_	_	_	_
20	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
21	HIV	HIV	PROPN	NNP	Number=Sing	_	_	_	_
22	long	long	ADJ	JJ	Degree=Pos	_	_	_	_
23	terminal	terminal	NOUN	NN	Number=Sing	_	_	_	_
24	repeat	repeat	NOUN	NN	Number=Sing	_	_	_	_
25	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
26	which	which	PRON	WDT	PronType=Rel	_	_	_	_
27	contains	contain	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
28	two	two	NUM	CD	NumType=Card	_	_	_	_
29	potential	potential	ADJ	JJ	Degree=Pos	_	_	_	_
30	NF	Nf	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
31	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
32	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_
33	B	b	NOUN	NN	Number=Sing	_	_	_	_
34	binding	binding	VERB	VBG	VerbForm=Ger	_	_	_	_
35	sites	site	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
36	)	)	PUNCT	-RRB-	_	_	_	_	_
37	by	by	ADP	IN	_	_	_	_	_
38	phorbol	phorbol	NOUN	NN	Number=Sing	_	_	_	_
39	ester	ester	NOUN	NN	Number=Sing	_	_	_	_
40	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
41	PMA	PMA	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
42	)	)	PUNCT	-RRB-	_	_	_	_	_
43	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
44	inhibited	inhibit	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
45	when	when	ADV	WRB	PronType=Int	_	_	_	_
46	it	it	PRON	PRP	Case=Nom|Gender=Neut|Number=Sing|Person=3|PronType=Prs	_	_	_	_
47	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
48	co-transfected	co-transfect	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
49	into	into	ADP	IN	_	_	_	_	_
50	CD4	CD4	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
51	+	+	SYM	SYM	_	_	_	_	_
52	T	t	NUM	CD	NumType=Card	_	_	_	_
53	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
54	with	with	ADP	IN	_	_	_	_	_
55	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
56	delta	delta	PROPN	NNP	Number=Sing	_	_	_	_
57	SP	sp	PROPN	NNP	Number=Sing	_	_	_	_
58	mutant	mutant	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
59	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1623
# text = Similarly the basal as well as TNF or IL1-induced activity of the MHC class I H-2Kb promoter can be inhibited by this mutant in two different cell lines.
1	Similarly	similarly	ADV	RB	_	_	_	_	_
2	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
3	basal	basal	NOUN	NN	Number=Sing	_	_	_	_
4	as	as	ADV	RB	_	_	_	_	_
5	well	well	ADV	RB	Degree=Pos	_	_	_	_
6	as	as	ADP	IN	_	_	_	_	_
7	TNF	TNF	PROPN	NNP	Number=Sing	_	_	_	_
8	or	or	CCONJ	CC	_	_	_	_	_
9	IL1	IL1	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
10	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
11	induced	induce	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
12	activity	activity	NOUN	NN	Number=Sing	_	_	_	_
13	of	of	ADP	IN	_	_	_	_	_
14	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
15	MHC	MHC	PROPN	NNP	Number=Sing	_	_	_	_
16	class	class	NOUN	NN	Number=Sing	_	_	_	_
17	I	I	PRON	PRP	Case=Nom|Number=Sing|Person=1|PronType=Prs	_	_	_	_
18	H	h	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	SpaceAfter=No
19	-2	-2	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
20	Kb	kb	NOUN	NN	Number=Sing	_	_	_	_
21	promoter	promoter	NOUN	NN	Number=Sing	_	_	_	_
22	can	can	AUX	MD	VerbForm=Fin	_	_	_	_
23	be	be	AUX	VB	VerbForm=Inf	_	_	_	_
24	inhibited	inhibit	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
25	by	by	ADP	IN	_	_	_	_	_
26	this	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
27	mutant	mutant	NOUN	NN	Number=Sing	_	_	_	_
28	in	in	ADP	IN	_	_	_	_	_
29	two	two	NUM	CD	NumType=Card	_	_	_	_
30	different	different	ADJ	JJ	Degree=Pos	_	_	_	_
31	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
32	lines	line	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
33	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1624
# text = These results constitute the first formal demonstration that these genes are regulated by members of the rel/NF-kappa B family.
1	These	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
2	results	result	NOUN	NNS	Number=Plur	_	_	_	_
3	constitute	constitute	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
4	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
5	first	first	ADV	RBS	_	_	_	_	_
6	formal	formal	ADJ	JJ	Degree=Pos	_	_	_	_
7	demonstration	demonstration	NOUN	NN	Number=Sing	_	_	_	_
8	that	that	PRON	WDT	PronType=Rel	_	_	_	_
9	these	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
10	genes	gene	NOUN	NNS	Number=Plur	_	_	_	_
11	are	be	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
12	regulated	regulate	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
13	by	by	ADP	IN	_	_	_	_	_
14	members	member	NOUN	NNS	Number=Plur	_	_	_	_
15	of	of	ADP	IN	_	_	_	_	_
16	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
17	rel/	rel/	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
18	NF	Nf	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
19	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
20	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_
21	B	b	NOUN	NN	Number=Sing	_	_	_	_
22	family	family	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
23	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 1625
# text = Document 003002588 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	003002588	003002588	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 1626
# text = Human MHC class II gene transcription directed by the carboxyl terminus of CIITA, one of the defective genes in type II MHC combined immune deficiency.
1	Human	human	PROPN	NNP	Number=Sing	_	_	_	_
2	MHC	MHC	PROPN	NNP	Number=Sing	_	_	_	_
3	class	class	NOUN	NN	Number=Sing	_	_	_	_
4	II	ii	NUM	CD	NumType=Card	_	_	_	_
5	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
6	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
7	directed	direct	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
8	by	by	ADP	IN	_	_	_	_	_
9	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
10	carboxyl	carboxyl	NOUN	NN	Number=Sing	_	_	_	_
11	terminus	terminus	NOUN	NN	Number=Sing	_	_	_	_
12	of	of	ADP	IN	_	_	_	_	_
13	CIITA	CIITA	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
14	,	,	PUNCT	,	_	_	_	_	_
15	one	one	NUM	CD	NumType=Card	_	_	_	_
16	of	of	ADP	IN	_	_	_	_	_
17	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
18	defective	defective	ADJ	JJ	Degree=Pos	_	_	_	_
19	genes	gene	NOUN	NNS	Number=Plur	_	_	_	_
20	in	in	ADP	IN	_	_	_	_	_
21	type	type	NOUN	NN	Number=Sing	_	_	_	_
22	II	ii	PROPN	NNP	Number=Sing	_	_	_	_
23	MHC	mhc	PROPN	NNP	Number=Sing	_	_	_	_
24	combined	combine	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
25	immune	immune	ADJ	JJ	Degree=Pos	_	_	_	_
26	deficiency	deficiency	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
27	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 1627
# text = Type II major histocompatibility complex combined immune deficiency (type II MHC CID or bare lymphocyte syndrome) is a congenital immunodeficiency disease characterized by absent MHC class II expression.
1	Type	type	NOUN	NN	Number=Sing	_	_	_	_
2	II	ii	NUM	CD	NumType=Card	_	_	_	_
3	major	major	ADJ	JJ	Degree=Pos	_	_	_	_
4	histocompatibility	histocompatibility	NOUN	NN	Number=Sing	_	_	_	_
5	complex	complex	NOUN	NN	Number=Sing	_	_	_	_
6	combined	combine	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
7	immune	immune	ADJ	JJ	Degree=Pos	_	_	_	_
8	deficiency	deficiency	NOUN	NN	Number=Sing	_	_	_	_
9	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
10	type	type	NOUN	NN	Number=Sing	_	_	_	_
11	II	ii	NUM	CD	NumType=Card	_	_	_	_
12	MHC	MHC	PROPN	NNP	Number=Sing	_	_	_	_
13	CID	CID	PROPN	NNP	Number=Sing	_	_	_	_
14	or	or	CCONJ	CC	_	_	_	_	_
15	bare	bear	ADJ	JJ	Degree=Pos	_	_	_	_
16	lymphocyte	lymphocyte	ADJ	JJ	Degree=Pos	_	_	_	_
17	syndrome	syndrome	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
18	)	)	PUNCT	-RRB-	_	_	_	_	_
19	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
20	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
21	congenital	congenital	ADJ	JJ	Degree=Pos	_	_	_	_
22	immunodeficiency	immunodeficiency	NOUN	NN	Number=Sing	_	_	_	_
23	disease	disease	NOUN	NN	Number=Sing	_	_	_	_
24	characterized	characterize	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
25	by	by	ADP	IN	_	_	_	_	_
26	absent	absent	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
27	MHC	MHC	PROPN	NNP	Number=Sing	_	_	_	_
28	class	class	NOUN	NN	Number=Sing	_	_	_	_
29	II	ii	NUM	CD	NumType=Card	_	_	_	_
30	expression	expression	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
31	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1628
# text = Four distinct complementation groups have been identified.
1	Four	four	NUM	CD	NumType=Card	_	_	_	_
2	distinct	distinct	ADJ	JJ	Degree=Pos	_	_	_	_
3	complementation	complementation	NOUN	NN	Number=Sing	_	_	_	_
4	groups	group	NOUN	NNS	Number=Plur	_	_	_	_
5	have	have	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
6	been	be	AUX	VBN	Tense=Past|VerbForm=Part	_	_	_	_
7	identified	identify	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	SpaceAfter=No
8	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1629
# text = Recently, the defective gene in group II type II MHC CID has been isolated and termed CIITA.
1	Recently	recently	ADV	RB	_	_	_	_	SpaceAfter=No
2	,	,	PUNCT	,	_	_	_	_	_
3	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
4	defective	defective	ADJ	JJ	Degree=Pos	_	_	_	_
5	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
6	in	in	ADP	IN	_	_	_	_	_
7	group	group	NOUN	NN	Number=Sing	_	_	_	_
8	II	ii	NUM	CD	NumType=Card	_	_	_	_
9	type	type	NOUN	NN	Number=Sing	_	_	_	_
10	II	ii	NUM	CD	NumType=Card	_	_	_	_
11	MHC	MHC	PROPN	NNP	Number=Sing	_	_	_	_
12	CID	CID	PROPN	NNP	Number=Sing	_	_	_	_
13	has	have	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
14	been	be	AUX	VBN	Tense=Past|VerbForm=Part	_	_	_	_
15	isolated	isolate	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
16	and	and	CCONJ	CC	_	_	_	_	_
17	termed	term	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
18	CIITA	CIITa	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
19	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1630
# text = Here, we demonstrate that CIITA is an MHC class II gene-specific transcription activator.
1	Here	here	ADV	RB	PronType=Dem	_	_	_	SpaceAfter=No
2	,	,	PUNCT	,	_	_	_	_	_
3	we	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
4	demonstrate	demonstrate	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
5	that	that	SCONJ	IN	_	_	_	_	_
6	CIITA	CIITA	PROPN	NNP	Number=Sing	_	_	_	_
7	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
8	an	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
9	MHC	MHC	PROPN	NNP	Number=Sing	_	_	_	_
10	class	class	NOUN	NN	Number=Sing	_	_	_	_
11	II	ii	NUM	CD	NumType=Card	_	_	_	_
12	gene-	gene-	SYM	SYM	_	_	_	_	SpaceAfter=No
13	specific	specific	ADJ	JJ	Degree=Pos	_	_	_	_
14	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
15	activator	activator	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
16	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1631
# text = The transcription activation function is provided by the N-terminal acidic domain (amino acids 26-137), which is experimentally exchangeable with a heterologous viral transcription-activating domain.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
3	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
4	function	function	NOUN	NN	Number=Sing	_	_	_	_
5	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
6	provided	provide	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
7	by	by	ADP	IN	_	_	_	_	_
8	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
9	N-	N-	SYM	SYM	_	_	_	_	SpaceAfter=No
10	terminal	terminal	ADJ	JJ	Degree=Pos	_	_	_	_
11	acidic	acidic	ADJ	JJ	Degree=Pos	_	_	_	_
12	domain	domain	NOUN	NN	Number=Sing	_	_	_	_
13	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
14	amino	amino	DET	DT	_	_	_	_	_
15	acids	acid	NOUN	NNS	Number=Plur	_	_	_	_
16	26	26	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
17	-	-	SYM	SYM	_	_	_	_	SpaceAfter=No
18	137	137	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
19	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
20	,	,	PUNCT	,	_	_	_	_	_
21	which	which	PRON	WDT	PronType=Rel	_	_	_	_
22	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
23	experimentally	experimentally	ADV	RB	_	_	_	_	_
24	exchangeable	exchangeable	ADJ	JJ	Degree=Pos	_	_	_	_
25	with	with	ADP	IN	_	_	_	_	_
26	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
27	heterologous	heterologous	ADJ	JJ	Degree=Pos	_	_	_	_
28	viral	viral	ADJ	JJ	Degree=Pos	_	_	_	_
29	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
30	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
31	activating	activate	VERB	VBG	VerbForm=Ger	_	_	_	_
32	domain	domain	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
33	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1632
# text = The specificity of CIITA for three major MHC class II genes, DR, DQ and DP, is mediated by its remaining C-terminal residues (amino acids 317-1130).
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	specificity	specificity	NOUN	NN	Number=Sing	_	_	_	_
3	of	of	ADP	IN	_	_	_	_	_
4	CIITA	CIITA	PROPN	NNP	Number=Sing	_	_	_	_
5	for	for	ADP	IN	_	_	_	_	_
6	three	three	NUM	CD	NumType=Card	_	_	_	_
7	major	major	ADJ	JJ	Degree=Pos	_	_	_	_
8	MHC	MHC	PROPN	NNP	Number=Sing	_	_	_	_
9	class	class	NOUN	NN	Number=Sing	_	_	_	_
10	II	ii	NUM	CD	NumType=Card	_	_	_	_
11	genes	gene	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
12	,	,	PUNCT	,	_	_	_	_	_
13	DR	dr	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
14	,	,	PUNCT	,	_	_	_	_	_
15	DQ	Dq	PROPN	NNP	Number=Sing	_	_	_	_
16	and	and	CCONJ	CC	_	_	_	_	_
17	DP	DP	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
18	,	,	PUNCT	,	_	_	_	_	_
19	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
20	mediated	mediate	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
21	by	by	ADP	IN	_	_	_	_	_
22	its	its	PRON	PRP$	Gender=Neut|Number=Sing|Person=3|Poss=Yes|PronType=Prs	_	_	_	_
23	remaining	remain	VERB	VBG	VerbForm=Ger	_	_	_	_
24	C-	C-	SYM	NFP	_	_	_	_	SpaceAfter=No
25	terminal	terminal	ADJ	JJ	Degree=Pos	_	_	_	_
26	residues	residue	NOUN	NNS	Number=Plur	_	_	_	_
27	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
28	amino	amino	DET	DT	_	_	_	_	_
29	acids	acid	NOUN	NNS	Number=Plur	_	_	_	_
30	317	317	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
31	-	-	SYM	SYM	_	_	_	_	SpaceAfter=No
32	1130	1130	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
33	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
34	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1633
# text = The transactivation of multiple cis elements, especially S and X2, of the DR alpha proximal promoter in group II CID cells is CIITA dependent.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	transactivation	transactivation	NOUN	NN	Number=Sing	_	_	_	_
3	of	of	ADP	IN	_	_	_	_	_
4	multiple	multiple	ADJ	JJ	Degree=Pos	_	_	_	_
5	cis	cis	NOUN	NN	Number=Sing	_	_	_	_
6	elements	element	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
7	,	,	PUNCT	,	_	_	_	_	_
8	especially	especially	ADV	RB	_	_	_	_	_
9	S	S	NOUN	NN	Number=Sing	_	_	_	_
10	and	and	CCONJ	CC	_	_	_	_	_
11	X2	X2	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
12	,	,	PUNCT	,	_	_	_	_	_
13	of	of	ADP	IN	_	_	_	_	_
14	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
15	DR	Dr	PROPN	NNP	Number=Sing	_	_	_	_
16	alpha	alpha	PROPN	NNP	Number=Sing	_	_	_	_
17	proximal	proximal	ADJ	JJ	Degree=Pos	_	_	_	_
18	promoter	promoter	NOUN	NN	Number=Sing	_	_	_	_
19	in	in	ADP	IN	_	_	_	_	_
20	group	group	NOUN	NN	Number=Sing	_	_	_	_
21	II	ii	NUM	CD	NumType=Card	_	_	_	_
22	CID	Cid	ADJ	JJ	Degree=Pos	_	_	_	_
23	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
24	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
25	CIITA	CIITA	X	GW	_	_	_	_	_
26	dependent	dependent	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
27	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1634
# text = Since CIITA overexpression in normal cells did not increase class II expression, we propose that initiation of CIITA expression serves as the on-off switch, while availability of downstream interactor(s) limits transcription.
1	Since	since	SCONJ	IN	_	_	_	_	_
2	CIITA	CIITA	PROPN	NNP	Number=Sing	_	_	_	_
3	overexpression	overexpression	NOUN	NN	Number=Sing	_	_	_	_
4	in	in	ADP	IN	_	_	_	_	_
5	normal	normal	ADJ	JJ	Degree=Pos	_	_	_	_
6	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
7	did	do	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
8	not	not	PART	RB	_	_	_	_	_
9	increase	increase	VERB	VB	VerbForm=Inf	_	_	_	_
10	class	class	NOUN	NN	Number=Sing	_	_	_	_
11	II	ii	NUM	CD	NumType=Card	_	_	_	_
12	expression	expression	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
13	,	,	PUNCT	,	_	_	_	_	_
14	we	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
15	propose	propose	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
16	that	that	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
17	initiation	initiation	NOUN	NN	Number=Sing	_	_	_	_
18	of	of	ADP	IN	_	_	_	_	_
19	CIITA	CIITA	PROPN	NNP	Number=Sing	_	_	_	_
20	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
21	serves	serve	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
22	as	as	ADP	IN	_	_	_	_	_
23	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
24	on	on	ADP	IN	_	_	_	_	SpaceAfter=No
25	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
26	off	off	ADJ	JJ	Degree=Pos	_	_	_	_
27	switch	switch	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
28	,	,	PUNCT	,	_	_	_	_	_
29	while	while	SCONJ	IN	_	_	_	_	_
30	availability	availability	NOUN	NN	Number=Sing	_	_	_	_
31	of	of	ADP	IN	_	_	_	_	_
32	downstream	downstream	ADJ	JJ	Degree=Pos	_	_	_	_
33	interactor	interactor	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
34	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
35	s	s	X	AFX	_	_	_	_	SpaceAfter=No
36	)	)	PUNCT	-RRB-	_	_	_	_	_
37	limits	limit	NOUN	NNS	Number=Plur	_	_	_	_
38	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
39	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 1635
# text = Document 003002594 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	003002594	003002594	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 1636
# text = Induction of Sp1 phosphorylation and NF-kappa B-independent HIV promoter domain activity in T lymphocytes stimulated by okadaic acid.
1	Induction	Induction	NOUN	NN	Number=Sing	_	_	_	_
2	of	of	ADP	IN	_	_	_	_	_
3	Sp1	Sp1	NUM	CD	NumType=Card	_	_	_	_
4	phosphorylation	phosphorylation	NOUN	NN	Number=Sing	_	_	_	_
5	and	and	CCONJ	CC	_	_	_	_	_
6	NF	Nf	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
7	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
8	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_
9	B	b	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
10	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
11	independent	independent	ADJ	JJ	Degree=Pos	_	_	_	_
12	HIV	Hiv	NOUN	NN	Number=Sing	_	_	_	_
13	promoter	promoter	NOUN	NN	Number=Sing	_	_	_	_
14	domain	domain	NOUN	NN	Number=Sing	_	_	_	_
15	activity	activity	NOUN	NN	Number=Sing	_	_	_	_
16	in	in	ADP	IN	_	_	_	_	_
17	T	t	PROPN	NNP	Number=Sing	_	_	_	_
18	lymphocytes	lymphocyte	NOUN	NNS	Number=Plur	_	_	_	_
19	stimulated	stimulate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
20	by	by	ADP	IN	_	_	_	_	_
21	okadaic	okadaic	ADJ	JJ	Degree=Pos	_	_	_	_
22	acid	acid	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
23	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 1637
# text = In contrast to the purely enhancer-dependent effect of cytokines such as TNF on the activity of the HIV regulatory region (LTR), we observed that okadaic acid (OKA) activates
1	In	in	ADP	IN	_	_	_	_	_
2	contrast	contrast	NOUN	NN	Number=Sing	_	_	_	_
3	to	to	ADP	IN	_	_	_	_	_
4	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
5	purely	purely	ADJ	JJ	Degree=Pos	_	_	_	_
6	enhancer	enhancer	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
7	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
8	dependent	dependent	ADJ	JJ	Degree=Pos	_	_	_	_
9	effect	effect	NOUN	NN	Number=Sing	_	_	_	_
10	of	of	ADP	IN	_	_	_	_	_
11	cytokines	cytokine	NOUN	NNS	Number=Plur	_	_	_	_
12	such	such	ADJ	JJ	Degree=Pos	_	_	_	_
13	as	as	ADP	IN	_	_	_	_	_
14	TNF	TNF	PROPN	NNP	Number=Sing	_	_	_	_
15	on	on	ADP	IN	_	_	_	_	_
16	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
17	activity	activity	NOUN	NN	Number=Sing	_	_	_	_
18	of	of	ADP	IN	_	_	_	_	_
19	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
20	HIV	HIV	PROPN	NNP	Number=Sing	_	_	_	_
21	regulatory	regulatory	ADJ	JJ	Degree=Pos	_	_	_	_
22	region	region	NOUN	NN	Number=Sing	_	_	_	_
23	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
24	LTR	LTR	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
25	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
26	,	,	PUNCT	,	_	_	_	_	_
27	we	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
28	observed	observe	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
29	that	that	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
30	okadaic	okadaic	ADJ	JJ	Degree=Pos	_	_	_	_
31	acid	acid	NOUN	NN	Number=Sing	_	_	_	_
32	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
33	OKA	OKA	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
34	)	)	PUNCT	-RRB-	_	_	_	_	_
35	activates	activate	NOUN	NNS	Number=Plur	_	_	_	_

# sent_id = 1638
# text = HIV transcription through both the enhancer, responding to the factor NF-kappa B, and the promoter domain of the LTR.
1	HIV	Hiv	NOUN	NN	Number=Sing	_	_	_	_
2	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
3	through	through	ADP	IN	_	_	_	_	_
4	both	both	CCONJ	CC	_	_	_	_	_
5	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
6	enhancer	enhancer	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
7	,	,	PUNCT	,	_	_	_	_	_
8	responding	respond	VERB	VBG	VerbForm=Ger	_	_	_	_
9	to	to	ADP	IN	_	_	_	_	_
10	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
11	factor	factor	NOUN	NN	Number=Sing	_	_	_	_
12	NF	Nf	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
13	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
14	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_
15	B	b	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
16	,	,	PUNCT	,	_	_	_	_	_
17	and	and	CCONJ	CC	_	_	_	_	_
18	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
19	promoter	promoter	NOUN	NN	Number=Sing	_	_	_	_
20	domain	domain	NOUN	NN	Number=Sing	_	_	_	_
21	of	of	ADP	IN	_	_	_	_	_
22	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
23	LTR	LTR	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
24	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1639
# text = The inducibility of HIV LTR-driven luciferase expression constructs in lymphoblastoid cells stimulated by OKA depended on both functional Sp1 binding elements and the ability of the TATA box to bind the protein TBP.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	inducibility	inducibility	NOUN	NN	Number=Sing	_	_	_	_
3	of	of	ADP	IN	_	_	_	_	_
4	HIV	HIV	PROPN	NNP	Number=Sing	_	_	_	_
5	LTR-	LTR-	PUNCT	:	_	_	_	_	SpaceAfter=No
6	driven	drive	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
7	luciferase	luciferase	NOUN	NN	Number=Sing	_	_	_	_
8	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
9	constructs	constructs	NOUN	NNS	Number=Plur	_	_	_	_
10	in	in	ADP	IN	_	_	_	_	_
11	lymphoblastoid	lymphoblastoid	ADJ	JJ	Degree=Pos	_	_	_	_
12	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
13	stimulated	stimulate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
14	by	by	ADP	IN	_	_	_	_	_
15	OKA	OKA	PROPN	NNP	Number=Sing	_	_	_	_
16	depended	depend	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
17	on	on	ADP	IN	_	_	_	_	_
18	both	both	DET	DT	_	_	_	_	_
19	functional	functional	ADJ	JJ	Degree=Pos	_	_	_	_
20	Sp1	sp1	NOUN	NN	Number=Sing	_	_	_	_
21	binding	bind	VERB	VBG	VerbForm=Ger	_	_	_	_
22	elements	element	NOUN	NNS	Number=Plur	_	_	_	_
23	and	and	CCONJ	CC	_	_	_	_	_
24	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
25	ability	ability	NOUN	NN	Number=Sing	_	_	_	_
26	of	of	ADP	IN	_	_	_	_	_
27	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
28	TATA	TATA	PROPN	NNP	Number=Sing	_	_	_	_
29	box	box	NOUN	NN	Number=Sing	_	_	_	_
30	to	to	PART	TO	_	_	_	_	_
31	bind	bind	VERB	VB	VerbForm=Inf	_	_	_	_
32	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
33	protein	protein	NOUN	NN	Number=Sing	_	_	_	_
34	TBP	Tbp	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
35	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1640
# text = In both transformed and normal lymphocytes, OKA stimulation induced intense phosphorylation of the constitutively expressed Sp1 protein in the nucleus, a property of OKA not shared by TNF, phorbol ester, or PHA and interleukin 2.
1	In	in	ADP	IN	_	_	_	_	_
2	both	both	CCONJ	CC	_	_	_	_	_
3	transformed	transformed	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
4	and	and	CCONJ	CC	_	_	_	_	_
5	normal	normal	ADJ	JJ	Degree=Pos	_	_	_	_
6	lymphocytes	lymphocyte	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
7	,	,	PUNCT	,	_	_	_	_	_
8	OKA	OKA	PROPN	NNP	Number=Sing	_	_	_	_
9	stimulation	stimulation	NOUN	NN	Number=Sing	_	_	_	_
10	induced	induce	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
11	intense	intense	ADJ	JJ	Degree=Pos	_	_	_	_
12	phosphorylation	phosphorylation	NOUN	NN	Number=Sing	_	_	_	_
13	of	of	ADP	IN	_	_	_	_	_
14	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
15	constitutively	constitutively	ADV	RB	_	_	_	_	_
16	expressed	express	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
17	Sp1	sp1	NUM	CD	NumType=Card	_	_	_	_
18	protein	protein	NOUN	NN	Number=Sing	_	_	_	_
19	in	in	ADP	IN	_	_	_	_	_
20	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
21	nucleus	nucleus	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
22	,	,	PUNCT	,	_	_	_	_	_
23	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
24	property	property	NOUN	NN	Number=Sing	_	_	_	_
25	of	of	ADP	IN	_	_	_	_	_
26	OKA	OKA	PROPN	NNP	Number=Sing	_	_	_	_
27	not	not	PART	RB	_	_	_	_	_
28	shared	share	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
29	by	by	ADP	IN	_	_	_	_	_
30	TNF	TNF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
31	,	,	PUNCT	,	_	_	_	_	_
32	phorbol	phorbol	NOUN	NN	Number=Sing	_	_	_	_
33	ester	ester	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
34	,	,	PUNCT	,	_	_	_	_	_
35	or	or	CCONJ	CC	_	_	_	_	_
36	PHA	PHa	PROPN	NNP	Number=Sing	_	_	_	_
37	and	and	CCONJ	CC	_	_	_	_	_
38	interleukin	interleukin	ADJ	JJ	Degree=Pos	_	_	_	_
39	2	2	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
40	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1641
# text = Responsiveness of LTR constructs deleted of kappa B elements to HIV Tat expression was increased upon OKA but not TNF stimulation.
1	Responsiveness	responsiveness	NOUN	NN	Number=Sing	_	_	_	_
2	of	of	ADP	IN	_	_	_	_	_
3	LTR	Ltr	PROPN	NNP	Number=Sing	_	_	_	_
4	constructs	construct	NOUN	NNS	Number=Plur	_	_	_	_
5	deleted	delet	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
6	of	of	ADP	IN	_	_	_	_	_
7	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_
8	B	b	NOUN	NN	Number=Sing	_	_	_	_
9	elements	element	NOUN	NNS	Number=Plur	_	_	_	_
10	to	to	ADP	IN	_	_	_	_	_
11	HIV	HIV	PROPN	NNP	Number=Sing	_	_	_	_
12	Tat	Tat	PROPN	NNP	Number=Sing	_	_	_	_
13	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
14	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
15	increased	increase	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
16	upon	upon	ADP	IN	_	_	_	_	_
17	OKA	OKA	PROPN	NNP	Number=Sing	_	_	_	_
18	but	but	CCONJ	CC	_	_	_	_	_
19	not	not	ADV	RB	_	_	_	_	_
20	TNF	Tnf	ADP	IN	_	_	_	_	_
21	stimulation	stimulation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
22	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1642
# text = Our results suggest that SP1 phosphorylation induced by OKA, a selective inhibitor of the serine-threonine phosphatase PP2A, facilitates the formation of a transcription complex involving general transcription factors, HIV Tat, and Sp1 proteins.
1	Our	we	PRON	PRP$	Number=Plur|Person=1|Poss=Yes|PronType=Prs	_	_	_	_
2	results	result	NOUN	NNS	Number=Plur	_	_	_	_
3	suggest	suggest	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
4	that	that	SCONJ	IN	_	_	_	_	_
5	SP1	SP1	NUM	CD	NumType=Card	_	_	_	_
6	phosphorylation	phosphorylation	NOUN	NN	Number=Sing	_	_	_	_
7	induced	induce	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
8	by	by	ADP	IN	_	_	_	_	_
9	OKA	OKA	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
10	,	,	PUNCT	,	_	_	_	_	_
11	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
12	selective	selective	ADJ	JJ	Degree=Pos	_	_	_	_
13	inhibitor	inhibitor	NOUN	NN	Number=Sing	_	_	_	_
14	of	of	ADP	IN	_	_	_	_	_
15	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
16	serine	serine	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
17	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
18	threonine	threonine	NUM	CD	NumType=Card	_	_	_	_
19	phosphatase	phosphatase	NOUN	NN	Number=Sing	_	_	_	_
20	PP2	Pp2	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
21	A	a	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
22	,	,	PUNCT	,	_	_	_	_	_
23	facilitates	facilitate	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
24	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
25	formation	formation	NOUN	NN	Number=Sing	_	_	_	_
26	of	of	ADP	IN	_	_	_	_	_
27	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
28	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
29	complex	complex	NOUN	NN	Number=Sing	_	_	_	_
30	involving	involve	VERB	VBG	VerbForm=Ger	_	_	_	_
31	general	general	ADJ	JJ	Degree=Pos	_	_	_	_
32	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
33	factors	factor	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
34	,	,	PUNCT	,	_	_	_	_	_
35	HIV	HIV	PROPN	NNP	Number=Sing	_	_	_	_
36	Tat	Tat	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
37	,	,	PUNCT	,	_	_	_	_	_
38	and	and	CCONJ	CC	_	_	_	_	_
39	Sp1	Sp1	NUM	CD	NumType=Card	_	_	_	_
40	proteins	protein	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
41	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1643
# text = The formation of this complex would increase, independently of an in synergy with NF-kappa B, the low basal activity of the HIV LTR observed in normal T lymphocytes.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	formation	formation	NOUN	NN	Number=Sing	_	_	_	_
3	of	of	ADP	IN	_	_	_	_	_
4	this	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
5	complex	complex	NOUN	NN	Number=Sing	_	_	_	_
6	would	would	AUX	MD	VerbForm=Fin	_	_	_	_
7	increase	increase	VERB	VB	VerbForm=Inf	_	_	_	SpaceAfter=No
8	,	,	PUNCT	,	_	_	_	_	_
9	independently	independently	ADV	RB	_	_	_	_	_
10	of	of	ADP	IN	_	_	_	_	_
11	an	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
12	in	in	ADP	IN	_	_	_	_	_
13	synergy	synergy	NOUN	NN	Number=Sing	_	_	_	_
14	with	with	ADP	IN	_	_	_	_	_
15	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
16	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
17	kappa	kappa	PROPN	NNP	Number=Sing	_	_	_	_
18	B	b	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
19	,	,	PUNCT	,	_	_	_	_	_
20	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
21	low	low	ADJ	JJ	Degree=Pos	_	_	_	_
22	basal	basal	ADJ	JJ	Degree=Pos	_	_	_	_
23	activity	activity	NOUN	NN	Number=Sing	_	_	_	_
24	of	of	ADP	IN	_	_	_	_	_
25	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
26	HIV	HIV	PROPN	NNP	Number=Sing	_	_	_	_
27	LTR	LTR	PROPN	NNP	Number=Sing	_	_	_	_
28	observed	observe	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
29	in	in	ADP	IN	_	_	_	_	_
30	normal	normal	ADJ	JJ	Degree=Pos	_	_	_	_
31	T	t	PROPN	NNP	Number=Sing	_	_	_	_
32	lymphocytes	lymphocyte	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
33	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 1644
# text = Document 003002595 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	003002595	003002595	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 1645
# text = Functional association of Nmi with Stat5 and Stat1 in IL-2- and IFNgamma-mediated signaling.
1	Functional	functional	ADJ	JJ	Degree=Pos	_	_	_	_
2	association	association	NOUN	NN	Number=Sing	_	_	_	_
3	of	of	ADP	IN	_	_	_	_	_
4	Nmi	Nmi	PROPN	NNP	Number=Sing	_	_	_	_
5	with	with	ADP	IN	_	_	_	_	_
6	Stat5	Stat5	PROPN	NNP	Number=Sing	_	_	_	_
7	and	and	CCONJ	CC	_	_	_	_	_
8	Stat1	Stat1	PROPN	NNP	Number=Sing	_	_	_	_
9	in	in	ADP	IN	_	_	_	_	_
10	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
11	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
12	2	2	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
13	-	-	PUNCT	HYPH	_	_	_	_	_
14	and	and	CCONJ	CC	_	_	_	_	_
15	IFNgamma	IFNgamma	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
16	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
17	mediated	mediate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
18	signaling	signaling	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
19	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 1646
# text = Using the coiled-coil region of Stat5b as the bait in a yeast two-hybrid screen, we identified the association of
1	Using	use	VERB	VBG	VerbForm=Ger	_	_	_	_
2	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
3	coiled	coil	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	SpaceAfter=No
4	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
5	coil	coil	NOUN	NN	Number=Sing	_	_	_	_
6	region	region	NOUN	NN	Number=Sing	_	_	_	_
7	of	of	ADP	IN	_	_	_	_	_
8	Stat5	Stat5	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
9	b	b	NOUN	NN	Number=Sing	_	_	_	_
10	as	as	ADP	IN	_	_	_	_	_
11	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
12	bait	bait	NOUN	NN	Number=Sing	_	_	_	_
13	in	in	ADP	IN	_	_	_	_	_
14	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
15	yeast	yeast	ADJ	JJS	Degree=Sup	_	_	_	_
16	two	two	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
17	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
18	hybrid	hybrid	NOUN	NN	Number=Sing	_	_	_	_
19	screen	screen	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
20	,	,	PUNCT	,	_	_	_	_	_
21	we	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
22	identified	identify	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
23	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
24	association	association	NOUN	NN	Number=Sing	_	_	_	_
25	of	of	ADP	IN	_	_	_	_	_

# sent_id = 1647
# text = Nmi, a protein of unknown function previously reported as an N-Myc interactor.
1	Nmi	Nmi	INTJ	UH	_	_	_	_	SpaceAfter=No
2	,	,	PUNCT	,	_	_	_	_	_
3	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
4	protein	protein	NOUN	NN	Number=Sing	_	_	_	_
5	of	of	ADP	IN	_	_	_	_	_
6	unknown	unknown	ADJ	JJ	Degree=Pos	_	_	_	_
7	function	function	NOUN	NN	Number=Sing	_	_	_	_
8	previously	previously	ADV	RB	_	_	_	_	_
9	reported	report	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
10	as	as	ADP	IN	_	_	_	_	_
11	an	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
12	N	N	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
13	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
14	Myc	Myc	PROPN	NNP	Number=Sing	_	_	_	_
15	interactor	interactor	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
16	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1648
# text = We further show that Nmi interacts with all STATs except Stat2.
1	We	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
2	further	further	ADV	RB	_	_	_	_	_
3	show	show	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
4	that	that	SCONJ	IN	_	_	_	_	_
5	Nmi	Nmi	PROPN	NNP	Number=Sing	_	_	_	_
6	interacts	interact	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
7	with	with	ADP	IN	_	_	_	_	_
8	all	all	DET	DT	_	_	_	_	_
9	STATs	STAT	NOUN	NNS	Number=Plur	_	_	_	_
10	except	except	ADP	IN	_	_	_	_	_
11	Stat2	stat2	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
12	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1649
# text = We evaluated two cytokine systems, IL-2 and IFNgamma, and demonstrate that Nmi augments STAT-mediated transcription in response to these cytokines.
1	We	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
2	evaluated	evaluate	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
3	two	two	NUM	CD	NumType=Card	_	_	_	_
4	cytokine	cytokine	NOUN	NN	Number=Sing	_	_	_	_
5	systems	system	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
6	,	,	PUNCT	,	_	_	_	_	_
7	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
8	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
9	2	2	NUM	CD	NumType=Card	_	_	_	_
10	and	and	CCONJ	CC	_	_	_	_	_
11	IFNgamma	IFNgamma	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
12	,	,	PUNCT	,	_	_	_	_	_
13	and	and	CCONJ	CC	_	_	_	_	_
14	demonstrate	demonstrate	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
15	that	that	SCONJ	IN	_	_	_	_	_
16	Nmi	Nmi	PROPN	NNP	Number=Sing	_	_	_	_
17	augments	augment	NOUN	NNS	Number=Plur	_	_	_	_
18	STAT	Stat	ADV	RB	_	_	_	_	SpaceAfter=No
19	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
20	mediated	mediated	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
21	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
22	in	in	ADP	IN	_	_	_	_	_
23	response	response	NOUN	NN	Number=Sing	_	_	_	_
24	to	to	ADP	IN	_	_	_	_	_
25	these	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
26	cytokines	cytokine	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
27	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1650
# text = Interestingly, Nmi lacks an intrinsic transcriptional activation domain; instead, Nmi enhances the association of CBP/p300 coactivator proteins with Stat1 and Stat5, and together with CBP/p300 can augment IL-2- and IFNgamma-dependent transcription.
1	Interestingly	Interestingly	ADV	RB	_	_	_	_	SpaceAfter=No
2	,	,	PUNCT	,	_	_	_	_	_
3	Nmi	Nmi	PROPN	NNP	Number=Sing	_	_	_	_
4	lacks	lack	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
5	an	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
6	intrinsic	intrinsic	ADJ	JJ	Degree=Pos	_	_	_	_
7	transcriptional	transcriptional	ADJ	JJ	Degree=Pos	_	_	_	_
8	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
9	domain	domain	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
10	;	;	PUNCT	,	_	_	_	_	_
11	instead	instead	ADV	RB	_	_	_	_	SpaceAfter=No
12	,	,	PUNCT	,	_	_	_	_	_
13	Nmi	Nmi	PROPN	NNP	Number=Sing	_	_	_	_
14	enhances	enhance	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
15	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
16	association	association	NOUN	NN	Number=Sing	_	_	_	_
17	of	of	ADP	IN	_	_	_	_	_
18	CBP	CBP	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
19	/	/	PUNCT	,	_	_	_	_	SpaceAfter=No
20	p300	p300	NUM	CD	NumType=Card	_	_	_	_
21	coactivator	coactivator	NOUN	NN	Number=Sing	_	_	_	_
22	proteins	protein	NOUN	NNS	Number=Plur	_	_	_	_
23	with	with	ADP	IN	_	_	_	_	_
24	Stat1	stat1	PROPN	NNP	Number=Sing	_	_	_	_
25	and	and	CCONJ	CC	_	_	_	_	_
26	Stat5	stat5	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
27	,	,	PUNCT	,	_	_	_	_	_
28	and	and	CCONJ	CC	_	_	_	_	_
29	together	together	ADV	RB	_	_	_	_	_
30	with	with	ADP	IN	_	_	_	_	_
31	CBP	CBP	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
32	/	/	PUNCT	,	_	_	_	_	SpaceAfter=No
33	p300	p300	NOUN	NN	Number=Sing	_	_	_	_
34	can	can	AUX	MD	VerbForm=Fin	_	_	_	_
35	augment	augment	VERB	VB	VerbForm=Inf	_	_	_	_
36	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
37	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
38	2	2	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
39	-	-	PUNCT	HYPH	_	_	_	_	_
40	and	and	CCONJ	CC	_	_	_	_	_
41	IFNgamma	IFNgamma	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
42	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
43	dependent	dependent	ADJ	JJ	Degree=Pos	_	_	_	_
44	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
45	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1651
# text = Therefore, our data not only reveal that Nmi can potentiate STAT-dependent transcription, but also suggest that it can augment coactivator protein recruitment to at least some members of a group of sequence-specific transcription factors.
1	Therefore	therefore	ADV	RB	_	_	_	_	SpaceAfter=No
2	,	,	PUNCT	,	_	_	_	_	_
3	our	we	PRON	PRP$	Number=Plur|Person=1|Poss=Yes|PronType=Prs	_	_	_	_
4	data	data	NOUN	NN	Number=Sing	_	_	_	_
5	not	not	ADV	RB	_	_	_	_	_
6	only	only	ADV	RB	_	_	_	_	_
7	reveal	reveal	VERB	VB	VerbForm=Inf	_	_	_	_
8	that	that	SCONJ	IN	_	_	_	_	_
9	Nmi	Nmi	PROPN	NNP	Number=Sing	_	_	_	_
10	can	can	AUX	MD	VerbForm=Fin	_	_	_	_
11	potentiate	potentiate	VERB	VB	VerbForm=Inf	_	_	_	_
12	STAT	Stat	ADV	RB	_	_	_	_	SpaceAfter=No
13	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
14	dependent	dependent	ADJ	JJ	Degree=Pos	_	_	_	_
15	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
16	,	,	PUNCT	,	_	_	_	_	_
17	but	but	CCONJ	CC	_	_	_	_	_
18	also	also	ADV	RB	_	_	_	_	_
19	suggest	suggest	VERB	VB	VerbForm=Inf	_	_	_	_
20	that	that	SCONJ	IN	_	_	_	_	_
21	it	it	PRON	PRP	Case=Nom|Gender=Neut|Number=Sing|Person=3|PronType=Prs	_	_	_	_
22	can	can	AUX	MD	VerbForm=Fin	_	_	_	_
23	augment	augment	VERB	VB	VerbForm=Inf	_	_	_	_
24	coactivator	coactivator	NOUN	NN	Number=Sing	_	_	_	_
25	protein	protein	NOUN	NN	Number=Sing	_	_	_	_
26	recruitment	recruitment	NOUN	NN	Number=Sing	_	_	_	_
27	to	to	ADP	IN	_	_	_	_	_
28	at	at	ADV	RB	_	_	_	_	_
29	least	least	ADV	RBS	Degree=Sup	_	_	_	_
30	some	some	DET	DT	_	_	_	_	_
31	members	member	NOUN	NNS	Number=Plur	_	_	_	_
32	of	of	ADP	IN	_	_	_	_	_
33	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
34	group	group	NOUN	NN	Number=Sing	_	_	_	_
35	of	of	ADP	IN	_	_	_	_	_
36	sequence	sequence	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
37	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
38	specific	specific	ADJ	JJ	Degree=Pos	_	_	_	_
39	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
40	factors	factor	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
41	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 1652
# text = Document 003002600 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	003002600	003002600	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 1653
# text = Vitamin
1	Vitamin	Vitamin	PROPN	NNP	Number=Sing	_	_	_	_

# sent_id = 1654
# text = D receptor 3'-untranslated region polymorphisms:
1	D	would	NOUN	NN	Number=Sing	_	_	_	_
2	receptor	receptor	NOUN	NN	Number=Sing	_	_	_	_
3	3	3	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
4	'	'	PUNCT	``	_	_	_	_	SpaceAfter=No
5	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
6	untranslated	untranslated	ADJ	JJ	Degree=Pos	_	_	_	_
7	region	region	NOUN	NN	Number=Sing	_	_	_	_
8	polymorphisms	polymorphism	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
9	:	:	PUNCT	:	_	_	_	_	_

# sent_id = 1655
# text = lack of effect on mRNA stability.
1	lack	lack	NOUN	NN	Number=Sing	_	_	_	_
2	of	of	ADP	IN	_	_	_	_	_
3	effect	effect	NOUN	NN	Number=Sing	_	_	_	_
4	on	on	ADP	IN	_	_	_	_	_
5	mRNA	mRNA	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
6	stability	stability	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
7	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 1656
# text = Allelic variation at the 3'-end of the vitamin D receptor (VDR) gene has been associated with a 3-5-fold increased risk of developing prostate cancer and with differences in bone mineralization.
1	Allelic	Allelic	ADJ	JJ	Degree=Pos	_	_	_	_
2	variation	variation	NOUN	NN	Number=Sing	_	_	_	_
3	at	at	ADP	IN	_	_	_	_	_
4	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
5	3	3	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
6	'	'	PUNCT	``	_	_	_	_	SpaceAfter=No
7	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
8	end	end	NOUN	NN	Number=Sing	_	_	_	_
9	of	of	ADP	IN	_	_	_	_	_
10	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
11	vitamin	vitamin	ADJ	JJ	Degree=Pos	_	_	_	_
12	D	d	NOUN	NN	Number=Sing	_	_	_	_
13	receptor	receptor	NOUN	NN	Number=Sing	_	_	_	_
14	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
15	VDR	VDR	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
16	)	)	PUNCT	-RRB-	_	_	_	_	_
17	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
18	has	have	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
19	been	be	AUX	VBN	Tense=Past|VerbForm=Part	_	_	_	_
20	associated	associate	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
21	with	with	ADP	IN	_	_	_	_	_
22	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
23	3	3	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
24	-	-	SYM	SYM	_	_	_	_	SpaceAfter=No
25	5	5	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
26	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
27	fold	fold	VERB	VB	VerbForm=Inf	_	_	_	_
28	increased	increase	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
29	risk	risk	NOUN	NN	Number=Sing	_	_	_	_
30	of	of	SCONJ	IN	_	_	_	_	_
31	developing	develop	VERB	VBG	VerbForm=Ger	_	_	_	_
32	prostate	prostate	NOUN	NN	Number=Sing	_	_	_	_
33	cancer	cancer	NOUN	NN	Number=Sing	_	_	_	_
34	and	and	CCONJ	CC	_	_	_	_	_
35	with	with	ADP	IN	_	_	_	_	_
36	differences	difference	NOUN	NNS	Number=Plur	_	_	_	_
37	in	in	ADP	IN	_	_	_	_	_
38	bone	bone	ADJ	JJ	Degree=Pos	_	_	_	_
39	mineralization	mineralization	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
40	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1657
# text = This genetic diversity does not alter the VDR protein structurally, but instead may be a marker(s) of other, nearby polymorphisms that influence message stability or translation.
1	This	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
2	genetic	genetic	ADJ	JJ	Degree=Pos	_	_	_	_
3	diversity	diversity	NOUN	NN	Number=Sing	_	_	_	_
4	does	do	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
5	not	not	PART	RB	_	_	_	_	_
6	alter	alter	VERB	VB	VerbForm=Inf	_	_	_	_
7	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
8	VDR	VDR	PROPN	NNP	Number=Sing	_	_	_	_
9	protein	protein	NOUN	NN	Number=Sing	_	_	_	_
10	structurally	structurally	ADV	RB	_	_	_	_	SpaceAfter=No
11	,	,	PUNCT	,	_	_	_	_	_
12	but	but	CCONJ	CC	_	_	_	_	_
13	instead	instead	ADV	RB	_	_	_	_	_
14	may	may	AUX	MD	VerbForm=Fin	_	_	_	_
15	be	be	AUX	VB	VerbForm=Inf	_	_	_	_
16	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
17	marker	marker	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
18	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
19	s	s	X	AFX	_	_	_	_	SpaceAfter=No
20	)	)	PUNCT	-RRB-	_	_	_	_	_
21	of	of	ADP	IN	_	_	_	_	_
22	other	other	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
23	,	,	PUNCT	,	_	_	_	_	_
24	nearby	nearby	ADJ	JJ	Degree=Pos	_	_	_	_
25	polymorphisms	polymorphism	NOUN	NNS	Number=Plur	_	_	_	_
26	that	that	PRON	WDT	PronType=Rel	_	_	_	_
27	influence	influence	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
28	message	message	NOUN	NN	Number=Sing	_	_	_	_
29	stability	stability	NOUN	NN	Number=Sing	_	_	_	_
30	or	or	CCONJ	CC	_	_	_	_	_
31	translation	translation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
32	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1658
# text = The work reported here was instigated to identify additional VDR 3'-UTR polymorphisms that may have functional significance and to then test whether these genetic variants alter message stability.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	work	work	NOUN	NN	Number=Sing	_	_	_	_
3	reported	report	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
4	here	here	ADV	RB	PronType=Dem	_	_	_	_
5	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
6	instigated	instigate	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
7	to	to	PART	TO	_	_	_	_	_
8	identify	identify	VERB	VB	VerbForm=Inf	_	_	_	_
9	additional	additional	ADJ	JJ	Degree=Pos	_	_	_	_
10	VDR	VDR	PROPN	NNP	Number=Sing	_	_	_	_
11	3	3	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
12	'	'	PUNCT	''	_	_	_	_	SpaceAfter=No
13	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
14	UTR	UTR	ADJ	JJR	Degree=Cmp	_	_	_	_
15	polymorphisms	polymorphism	NOUN	NNS	Number=Plur	_	_	_	_
16	that	that	PRON	WDT	PronType=Rel	_	_	_	_
17	may	may	AUX	MD	VerbForm=Fin	_	_	_	_
18	have	have	VERB	VB	VerbForm=Inf	_	_	_	_
19	functional	functional	ADJ	JJ	Degree=Pos	_	_	_	_
20	significance	significance	NOUN	NN	Number=Sing	_	_	_	_
21	and	and	CCONJ	CC	_	_	_	_	_
22	to	to	ADP	IN	_	_	_	_	_
23	then	then	ADV	RB	PronType=Dem	_	_	_	_
24	test	test	NOUN	NN	Number=Sing	_	_	_	_
25	whether	whether	SCONJ	IN	_	_	_	_	_
26	these	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
27	genetic	genetic	ADJ	JJ	Degree=Pos	_	_	_	_
28	variants	variant	NOUN	NNS	Number=Plur	_	_	_	_
29	alter	alter	NOUN	NN	Number=Sing	_	_	_	_
30	message	message	NOUN	NN	Number=Sing	_	_	_	_
31	stability	stability	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
32	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1659
# text = Initially, four novel, frequently occurring sequence variants were identified that associated with two common haplotypes that were described previously.
1	Initially	initially	ADV	RB	_	_	_	_	SpaceAfter=No
2	,	,	PUNCT	,	_	_	_	_	_
3	four	four	NUM	CD	NumType=Card	_	_	_	_
4	novel	novel	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
5	,	,	PUNCT	,	_	_	_	_	_
6	frequently	frequently	ADV	RB	_	_	_	_	_
7	occurring	occurre	VERB	VBG	VerbForm=Ger	_	_	_	_
8	sequence	sequence	NOUN	NN	Number=Sing	_	_	_	_
9	variants	variant	NOUN	NNS	Number=Plur	_	_	_	_
10	were	be	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
11	identified	identify	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
12	that	that	SCONJ	IN	_	_	_	_	_
13	associated	associate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
14	with	with	ADP	IN	_	_	_	_	_
15	two	two	NUM	CD	NumType=Card	_	_	_	_
16	common	common	ADJ	JJ	Degree=Pos	_	_	_	_
17	haplotypes	haplotype	NOUN	NNS	Number=Plur	_	_	_	_
18	that	that	PRON	WDT	PronType=Rel	_	_	_	_
19	were	be	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
20	described	describe	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
21	previously	previously	ADV	RB	_	_	_	_	SpaceAfter=No
22	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1660
# text = These common sequence variants were not found within three message-destabilizing elements that we mapped within the 3'-UTR of the vitamin D receptor mRNA.
1	These	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
2	common	common	ADJ	JJ	Degree=Pos	_	_	_	_
3	sequence	sequence	NOUN	NN	Number=Sing	_	_	_	_
4	variants	variant	NOUN	NNS	Number=Plur	_	_	_	_
5	were	be	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
6	not	not	PART	RB	_	_	_	_	_
7	found	find	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
8	within	within	ADP	IN	_	_	_	_	_
9	three	three	NUM	CD	NumType=Card	_	_	_	_
10	message	message	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
11	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
12	destabilizing	destabilize	VERB	VBG	VerbForm=Ger	_	_	_	_
13	elements	element	NOUN	NNS	Number=Plur	_	_	_	_
14	that	that	PRON	WDT	PronType=Rel	_	_	_	_
15	we	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
16	mapped	map	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
17	within	within	ADP	IN	_	_	_	_	_
18	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
19	3	3	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
20	'	'	PUNCT	``	_	_	_	_	SpaceAfter=No
21	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
22	UTR	Utr	ADP	IN	_	_	_	_	_
23	of	of	ADP	IN	_	_	_	_	_
24	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
25	vitamin	vitamin	ADJ	JJ	Degree=Pos	_	_	_	_
26	D	would	NOUN	NN	Number=Sing	_	_	_	_
27	receptor	receptor	NOUN	NN	Number=Sing	_	_	_	_
28	mRNA	mRNA	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
29	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1661
# text = Furthermore, the two VDR 3'-UTR haplotypes conferred an identical half-life on a heterologous beta-globin reporter gene, in an in vitro assay.
1	Furthermore	furthermore	ADV	RB	_	_	_	_	SpaceAfter=No
2	,	,	PUNCT	,	_	_	_	_	_
3	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
4	two	two	NUM	CD	NumType=Card	_	_	_	_
5	VDR	Vdr	NOUN	NN	Number=Sing	_	_	_	_
6	3	3	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
7	'	'	PUNCT	``	_	_	_	_	SpaceAfter=No
8	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
9	UTR	UTR	PROPN	NNP	Number=Sing	_	_	_	_
10	haplotypes	haplotype	NOUN	NNS	Number=Plur	_	_	_	_
11	conferred	confer	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
12	an	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
13	identical	identical	ADJ	JJ	Degree=Pos	_	_	_	_
14	half	half	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
15	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
16	life	life	NOUN	NN	Number=Sing	_	_	_	_
17	on	on	ADP	IN	_	_	_	_	_
18	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
19	heterologous	heterologous	ADJ	JJ	Degree=Pos	_	_	_	_
20	beta	beta	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
21	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
22	globin	globin	ADJ	JJ	Degree=Pos	_	_	_	_
23	reporter	reporter	NOUN	NN	Number=Sing	_	_	_	_
24	gene	gene	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
25	,	,	PUNCT	,	_	_	_	_	_
26	in	in	ADP	IN	_	_	_	_	_
27	an	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
28	in	in	ADP	IN	_	_	_	_	_
29	vitro	vitro	ADJ	JJ	Degree=Pos	_	_	_	_
30	assay	assay	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
31	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1662
# text = We therefore conclude that common polymorphisms within the VDR 3'-UTR do not influence message stability.
1	We	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
2	therefore	therefore	ADV	RB	_	_	_	_	_
3	conclude	conclude	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
4	that	that	SCONJ	IN	_	_	_	_	_
5	common	common	ADJ	JJ	Degree=Pos	_	_	_	_
6	polymorphisms	polymorphism	NOUN	NNS	Number=Plur	_	_	_	_
7	within	within	ADP	IN	_	_	_	_	_
8	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
9	VDR	Vdr	PROPN	NNP	Number=Sing	_	_	_	_
10	3	3	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
11	'	'	PUNCT	''	_	_	_	_	SpaceAfter=No
12	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
13	UTR	Utr	PROPN	NNP	Number=Sing	_	_	_	_
14	do	do	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
15	not	not	PART	RB	_	_	_	_	_
16	influence	influence	VERB	VB	VerbForm=Inf	_	_	_	_
17	message	message	NOUN	NN	Number=Sing	_	_	_	_
18	stability	stability	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
19	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 1663
# text = Document 0030031 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	0030031	0030031	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 1664
# text = Circadian rhythm of glucocorticoid receptors in human peripheral leukocytes and their reactivity to glucocorticoids.
1	Circadian	Circadian	ADJ	JJ	Degree=Pos	_	_	_	_
2	rhythm	rhythm	NOUN	NN	Number=Sing	_	_	_	_
3	of	of	ADP	IN	_	_	_	_	_
4	glucocorticoid	glucocorticoid	ADJ	JJ	Degree=Pos	_	_	_	_
5	receptors	receptor	NOUN	NNS	Number=Plur	_	_	_	_
6	in	in	ADP	IN	_	_	_	_	_
7	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
8	peripheral	peripheral	ADJ	JJ	Degree=Pos	_	_	_	_
9	leukocytes	leukocyte	NOUN	NNS	Number=Plur	_	_	_	_
10	and	and	CCONJ	CC	_	_	_	_	_
11	their	they	PRON	PRP$	Number=Plur|Person=3|Poss=Yes|PronType=Prs	_	_	_	_
12	reactivity	reactivity	NOUN	NN	Number=Sing	_	_	_	_
13	to	to	ADP	IN	_	_	_	_	_
14	glucocorticoids	glucocorticoid	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
15	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 1665
# text = 1) There exists a CR of GR in human leukocytes, PMN, and monocytes with the peak values from 0400 to 0800 hr and the trough values between 2300 and 0000 hr.
1	1	1	X	LS	_	_	_	_	SpaceAfter=No
2	)	)	PUNCT	-RRB-	_	_	_	_	_
3	There	there	PRON	EX	_	_	_	_	_
4	exists	exist	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
5	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
6	CR	Cr	NOUN	NN	Number=Sing	_	_	_	_
7	of	of	ADP	IN	_	_	_	_	_
8	GR	Gr	PROPN	NNP	Number=Sing	_	_	_	_
9	in	in	ADP	IN	_	_	_	_	_
10	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
11	leukocytes	leukocyte	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
12	,	,	PUNCT	,	_	_	_	_	_
13	PMN	Pmn	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
14	,	,	PUNCT	,	_	_	_	_	_
15	and	and	CCONJ	CC	_	_	_	_	_
16	monocytes	monocyte	NOUN	NNS	Number=Plur	_	_	_	_
17	with	with	ADP	IN	_	_	_	_	_
18	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
19	peak	peak	NOUN	NN	Number=Sing	_	_	_	_
20	values	value	NOUN	NNS	Number=Plur	_	_	_	_
21	from	from	ADP	IN	_	_	_	_	_
22	0400	0400	NUM	CD	NumType=Card	_	_	_	_
23	to	to	ADP	IN	_	_	_	_	_
24	0800	0800	NUM	CD	NumType=Card	_	_	_	_
25	hr	hr	NOUN	NN	Number=Sing	_	_	_	_
26	and	and	CCONJ	CC	_	_	_	_	_
27	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
28	trough	trough	ADJ	JJ	Degree=Pos	_	_	_	_
29	values	value	NOUN	NNS	Number=Plur	_	_	_	_
30	between	between	ADP	IN	_	_	_	_	_
31	2300	2300	NUM	CD	NumType=Card	_	_	_	_
32	and	and	CCONJ	CC	_	_	_	_	_
33	0000	0000	NUM	CD	NumType=Card	_	_	_	_
34	hr	hr	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
35	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1666
# text = The difference between them was significant statistically.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	difference	difference	NOUN	NN	Number=Sing	_	_	_	_
3	between	between	ADP	IN	_	_	_	_	_
4	them	they	PRON	PRP	Case=Acc|Number=Plur|Person=3|PronType=Prs	_	_	_	_
5	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
6	significant	significant	ADJ	JJ	Degree=Pos	_	_	_	_
7	statistically	statistically	ADV	RB	_	_	_	_	SpaceAfter=No
8	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1667
# text = 2) The FI of the chemotactic migration rate of PMN by cortisol also showed diurnal changes which were synchronous with that of GR.
1	2	2	X	LS	_	_	_	_	SpaceAfter=No
2	)	)	PUNCT	-RRB-	_	_	_	_	_
3	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
4	FI	fi	PROPN	NNP	Number=Sing	_	_	_	_
5	of	of	ADP	IN	_	_	_	_	_
6	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
7	chemotactic	chemotactic	ADJ	JJ	Degree=Pos	_	_	_	_
8	migration	migration	NOUN	NN	Number=Sing	_	_	_	_
9	rate	rate	NOUN	NN	Number=Sing	_	_	_	_
10	of	of	ADP	IN	_	_	_	_	_
11	PMN	PMN	PROPN	NNP	Number=Sing	_	_	_	_
12	by	by	ADP	IN	_	_	_	_	_
13	cortisol	cortisol	PROPN	NNP	Number=Sing	_	_	_	_
14	also	also	ADV	RB	_	_	_	_	_
15	showed	show	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
16	diurnal	diurnal	ADJ	JJ	Degree=Pos	_	_	_	_
17	changes	change	NOUN	NNS	Number=Plur	_	_	_	_
18	which	which	PRON	WDT	PronType=Rel	_	_	_	_
19	were	be	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
20	synchronous	synchronous	ADJ	JJ	Degree=Pos	_	_	_	_
21	with	with	ADP	IN	_	_	_	_	_
22	that	that	PRON	DT	Number=Sing|PronType=Dem	_	_	_	_
23	of	of	ADP	IN	_	_	_	_	_
24	GR	GR	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
25	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1668
# text = This indicates that the CR of GR may be of functional significance.
1	This	this	PRON	DT	Number=Sing|PronType=Dem	_	_	_	_
2	indicates	indicate	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
3	that	that	SCONJ	IN	_	_	_	_	_
4	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
5	CR	Cr	NOUN	NN	Number=Sing	_	_	_	_
6	of	of	ADP	IN	_	_	_	_	_
7	GR	GR	PROPN	NNP	Number=Sing	_	_	_	_
8	may	may	AUX	MD	VerbForm=Fin	_	_	_	_
9	be	be	AUX	VB	VerbForm=Inf	_	_	_	_
10	of	of	ADP	IN	_	_	_	_	_
11	functional	functional	ADJ	JJ	Degree=Pos	_	_	_	_
12	significance	significance	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
13	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1669
# text = 3) In Cushing's syndrome, the CR of GR was normal in spite of the fact that the CR of plasma cortisol was disturbed.
1	3	3	X	LS	_	_	_	_	SpaceAfter=No
2	)	)	PUNCT	-RRB-	_	_	_	_	_
3	In	in	ADP	IN	_	_	_	_	_
4	Cushing	Cushing	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
5	's	's	PART	POS	_	_	_	_	_
6	syndrome	syndrome	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
7	,	,	PUNCT	,	_	_	_	_	_
8	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
9	CR	Cr	PROPN	NNP	Number=Sing	_	_	_	_
10	of	of	ADP	IN	_	_	_	_	_
11	GR	GR	PROPN	NNP	Number=Sing	_	_	_	_
12	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
13	normal	normal	ADJ	JJ	Degree=Pos	_	_	_	_
14	in	in	ADP	IN	_	_	_	_	_
15	spite	spite	NOUN	NN	Number=Sing	_	_	_	_
16	of	of	ADP	IN	_	_	_	_	_
17	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
18	fact	fact	NOUN	NN	Number=Sing	_	_	_	_
19	that	that	SCONJ	IN	_	_	_	_	_
20	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
21	CR	Cr	NOUN	NN	Number=Sing	_	_	_	_
22	of	of	ADP	IN	_	_	_	_	_
23	plasma	plasma	NOUN	NN	Number=Sing	_	_	_	_
24	cortisol	cortisol	NOUN	NN	Number=Sing	_	_	_	_
25	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
26	disturbed	distur	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
27	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1670
# text = This indicates the independency of the CR of GR from that of cortisol.
1	This	this	PRON	DT	Number=Sing|PronType=Dem	_	_	_	_
2	indicates	indicate	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
3	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
4	independency	independency	NOUN	NN	Number=Sing	_	_	_	_
5	of	of	ADP	IN	_	_	_	_	_
6	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
7	CR	CR	PROPN	NNP	Number=Sing	_	_	_	_
8	of	of	ADP	IN	_	_	_	_	_
9	GR	GR	PROPN	NNP	Number=Sing	_	_	_	_
10	from	from	ADP	IN	_	_	_	_	_
11	that	that	PRON	DT	Number=Sing|PronType=Dem	_	_	_	_
12	of	of	ADP	IN	_	_	_	_	_
13	cortisol	cortisol	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
14	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1671
# text = 4) In apoplexy caused by brain ischemia, the CR of GR was abolished in patients with basal lesions but preserved when the lesions were located in the cerebral cortex.
1	4	4	X	LS	_	_	_	_	SpaceAfter=No
2	)	)	PUNCT	-RRB-	_	_	_	_	_
3	In	in	ADP	IN	_	_	_	_	_
4	apoplexy	apoplexy	NOUN	NN	Number=Sing	_	_	_	_
5	caused	cause	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
6	by	by	ADP	IN	_	_	_	_	_
7	brain	brain	NOUN	NN	Number=Sing	_	_	_	_
8	ischemia	ischemion	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
9	,	,	PUNCT	,	_	_	_	_	_
10	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
11	CR	CR	PROPN	NNP	Number=Sing	_	_	_	_
12	of	of	ADP	IN	_	_	_	_	_
13	GR	GR	PROPN	NNP	Number=Sing	_	_	_	_
14	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
15	abolished	abolish	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
16	in	in	ADP	IN	_	_	_	_	_
17	patients	patient	NOUN	NN	Number=Sing	_	_	_	_
18	with	with	ADP	IN	_	_	_	_	_
19	basal	basal	ADJ	JJ	Degree=Pos	_	_	_	_
20	lesions	lesion	NOUN	NNS	Number=Plur	_	_	_	_
21	but	but	CCONJ	CC	_	_	_	_	_
22	preserved	preserve	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
23	when	when	ADV	WRB	PronType=Int	_	_	_	_
24	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
25	lesions	lesion	NOUN	NNS	Number=Plur	_	_	_	_
26	were	be	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
27	located	locate	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
28	in	in	ADP	IN	_	_	_	_	_
29	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
30	cerebral	cerebral	ADJ	JJ	Degree=Pos	_	_	_	_
31	cortex	cortex	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
32	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1672
# text = These results strongly suggest that the main "circadian pacemaker" of GR is located in the basal brain, most probably in the suprachiasmatic nuclei as has been suggested for rodents.
1	These	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
2	results	result	NOUN	NNS	Number=Plur	_	_	_	_
3	strongly	strongly	ADV	RB	_	_	_	_	_
4	suggest	suggest	VERB	VB	VerbForm=Inf	_	_	_	_
5	that	that	SCONJ	IN	_	_	_	_	_
6	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
7	main	main	ADJ	JJ	Degree=Pos	_	_	_	_
8	"	"	PUNCT	``	_	_	_	_	SpaceAfter=No
9	circadian	circadian	ADJ	JJ	Degree=Pos	_	_	_	_
10	pacemaker	pacemaker	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
11	"	"	PUNCT	''	_	_	_	_	_
12	of	of	ADP	IN	_	_	_	_	_
13	GR	GR	PROPN	NNP	Number=Sing	_	_	_	_
14	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
15	located	locate	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
16	in	in	ADP	IN	_	_	_	_	_
17	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
18	basal	basal	ADJ	JJ	Degree=Pos	_	_	_	_
19	brain	brain	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
20	,	,	PUNCT	,	_	_	_	_	_
21	most	most	ADV	RBS	_	_	_	_	_
22	probably	probably	ADV	RB	_	_	_	_	_
23	in	in	ADP	IN	_	_	_	_	_
24	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
25	suprachiasmatic	suprachiasmatic	ADJ	JJ	Degree=Pos	_	_	_	_
26	nuclei	nuclei	NOUN	NN	Number=Sing	_	_	_	_
27	as	as	SCONJ	IN	_	_	_	_	_
28	has	have	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
29	been	be	AUX	VBN	Tense=Past|VerbForm=Part	_	_	_	_
30	suggested	suggest	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
31	for	for	ADP	IN	_	_	_	_	_
32	rodents	rodent	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
33	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 1673
# text = Document 0030032 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	0030032	0030032	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 1674
# text = Progesterone suppression of pregnancy lymphocytes is not mediated by glucocorticoid effect.
1	Progesterone	Progesterone	NOUN	NN	Number=Sing	_	_	_	_
2	suppression	suppression	NOUN	NN	Number=Sing	_	_	_	_
3	of	of	ADP	IN	_	_	_	_	_
4	pregnancy	pregnancy	ADJ	JJ	Degree=Pos	_	_	_	_
5	lymphocytes	lymphocyte	NOUN	NNS	Number=Plur	_	_	_	_
6	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
7	not	not	PART	RB	_	_	_	_	_
8	mediated	mediate	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
9	by	by	ADP	IN	_	_	_	_	_
10	glucocorticoid	glucocorticoid	ADJ	JJ	Degree=Pos	_	_	_	_
11	effect	effect	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
12	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 1675
# text = This study investigated whether the suppressive effect of progesterone on pregnancy lymphocytes is mediated by specific progesterone receptors.
1	This	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
2	study	study	NOUN	NN	Number=Sing	_	_	_	_
3	investigated	investigate	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
4	whether	whether	SCONJ	IN	_	_	_	_	_
5	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
6	suppressive	suppressive	ADJ	JJ	Degree=Pos	_	_	_	_
7	effect	effect	NOUN	NN	Number=Sing	_	_	_	_
8	of	of	ADP	IN	_	_	_	_	_
9	progesterone	progesterone	NOUN	NN	Number=Sing	_	_	_	_
10	on	on	ADP	IN	_	_	_	_	_
11	pregnancy	pregnancy	ADJ	JJ	Degree=Pos	_	_	_	_
12	lymphocytes	lymphocyte	NOUN	NNS	Number=Plur	_	_	_	_
13	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
14	mediated	mediate	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
15	by	by	ADP	IN	_	_	_	_	_
16	specific	specific	ADJ	JJ	Degree=Pos	_	_	_	_
17	progesterone	progesterone	NOUN	NN	Number=Sing	_	_	_	_
18	receptors	receptor	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
19	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1676
# text = The effects of a competitive progesterone antagonist (RU486) and a specific glucocorticoid receptor blocker (RU43044) were tested on the release of a blocking factor by progesterone-treated pregnancy lymphocytes.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	effects	effect	NOUN	NNS	Number=Plur	_	_	_	_
3	of	of	ADP	IN	_	_	_	_	_
4	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
5	competitive	competitive	ADJ	JJ	Degree=Pos	_	_	_	_
6	progesterone	progesterone	NOUN	NN	Number=Sing	_	_	_	_
7	antagonist	antagonist	NOUN	NN	Number=Sing	_	_	_	_
8	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
9	RU486	RU486	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
10	)	)	PUNCT	-RRB-	_	_	_	_	_
11	and	and	CCONJ	CC	_	_	_	_	_
12	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
13	specific	specific	ADJ	JJ	Degree=Pos	_	_	_	_
14	glucocorticoid	glucocorticoid	NOUN	NN	Number=Sing	_	_	_	_
15	receptor	receptor	NOUN	NN	Number=Sing	_	_	_	_
16	blocker	blocker	NOUN	NN	Number=Sing	_	_	_	_
17	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
18	RU43044	RU43044	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
19	)	)	PUNCT	-RRB-	_	_	_	_	_
20	were	be	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
21	tested	test	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
22	on	on	ADP	IN	_	_	_	_	_
23	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
24	release	release	NOUN	NN	Number=Sing	_	_	_	_
25	of	of	ADP	IN	_	_	_	_	_
26	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
27	blocking	block	VERB	VBG	VerbForm=Ger	_	_	_	_
28	factor	factor	NOUN	NN	Number=Sing	_	_	_	_
29	by	by	ADP	IN	_	_	_	_	_
30	progesterone	progesterone	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	SpaceAfter=No
31	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
32	treated	treat	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
33	pregnancy	pregnancy	NOUN	NN	Number=Sing	_	_	_	_
34	lymphocytes	lymphocyte	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
35	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1677
# text = RU 486 tested at an equal concentration as progesterone significantly inhibited the production of the blocking factor, while RU 43044 was without effect.
1	RU	Ru	PROPN	NNP	Number=Sing	_	_	_	_
2	486	486	NUM	CD	NumType=Card	_	_	_	_
3	tested	test	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
4	at	at	ADP	IN	_	_	_	_	_
5	an	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
6	equal	equal	ADJ	JJ	Degree=Pos	_	_	_	_
7	concentration	concentration	NOUN	NN	Number=Sing	_	_	_	_
8	as	as	SCONJ	IN	_	_	_	_	_
9	progesterone	progesterone	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
10	significantly	significantly	ADV	RB	_	_	_	_	_
11	inhibited	inhibit	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
12	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
13	production	production	NOUN	NN	Number=Sing	_	_	_	_
14	of	of	ADP	IN	_	_	_	_	_
15	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
16	blocking	blocking	NOUN	NN	Number=Sing	_	_	_	_
17	factor	factor	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
18	,	,	PUNCT	,	_	_	_	_	_
19	while	while	SCONJ	IN	_	_	_	_	_
20	RU	RU	PROPN	NNP	Number=Sing	_	_	_	_
21	43044	43044	NUM	CD	NumType=Card	_	_	_	_
22	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
23	without	without	ADP	IN	_	_	_	_	_
24	effect	effect	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
25	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1678
# text = These data suggest that in pregnancy, lymphocyte progesterone acts on specific progesterone receptors and glucocorticoid binding sites are not involved.
1	These	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
2	data	data	NOUN	NN	Number=Sing	_	_	_	_
3	suggest	suggest	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
4	that	that	SCONJ	IN	_	_	_	_	_
5	in	in	ADP	IN	_	_	_	_	_
6	pregnancy	pregnancy	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
7	,	,	PUNCT	,	_	_	_	_	_
8	lymphocyte	lymphocyte	NOUN	NN	Number=Sing	_	_	_	_
9	progesterone	progesterone	NOUN	NN	Number=Sing	_	_	_	_
10	acts	act	NOUN	NNS	Number=Plur	_	_	_	_
11	on	on	ADP	IN	_	_	_	_	_
12	specific	specific	ADJ	JJ	Degree=Pos	_	_	_	_
13	progesterone	progesterone	NOUN	NN	Number=Sing	_	_	_	_
14	receptors	receptor	NOUN	NNS	Number=Plur	_	_	_	_
15	and	and	CCONJ	CC	_	_	_	_	_
16	glucocorticoid	glucocorticoid	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
17	binding	binding	VERB	VBG	VerbForm=Ger	_	_	_	_
18	sites	site	NOUN	NNS	Number=Plur	_	_	_	_
19	are	be	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
20	not	not	PART	RB	_	_	_	_	_
21	involved	involved	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
22	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 1679
# text = Document 0030033 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	0030033	0030033	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 1680
# text = Infection with Theileria annulata induces expression of matrix metalloproteinase 9 and transcription factor AP-1 in bovine leucocytes.
1	Infection	Infection	NOUN	NN	Number=Sing	_	_	_	_
2	with	with	ADP	IN	_	_	_	_	_
3	Theileria	Theileria	PROPN	NNP	Number=Sing	_	_	_	_
4	annulata	annulata	PART	TO	Abbr=Yes	_	_	_	_
5	induces	induce	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
6	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
7	of	of	ADP	IN	_	_	_	_	_
8	matrix	matrix	NUM	CD	NumType=Card	_	_	_	_
9	metalloproteinase	metalloproteinase	NOUN	NN	Number=Sing	_	_	_	_
10	9	9	NUM	CD	NumType=Card	_	_	_	_
11	and	and	CCONJ	CC	_	_	_	_	_
12	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
13	factor	factor	NOUN	NN	Number=Sing	_	_	_	_
14	AP	ap	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
15	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
16	1	1	NUM	CD	NumType=Card	_	_	_	_
17	in	in	ADP	IN	_	_	_	_	_
18	bovine	bovine	ADJ	JJ	Degree=Pos	_	_	_	_
19	leucocytes	leucocyte	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
20	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 1681
# text = Theileria annulata infects bovine leucocytes and results in their reversible transformation such that they become immortalised and metastatic.
1	Theileria	Theileria	PROPN	NNP	Number=Sing	_	_	_	_
2	annulata	annulata	PART	TO	Abbr=Yes	_	_	_	_
3	infects	infect	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
4	bovine	bovine	NOUN	NN	Number=Sing	_	_	_	_
5	leucocytes	leucocyte	NOUN	NNS	Number=Plur	_	_	_	_
6	and	and	CCONJ	CC	_	_	_	_	_
7	results	result	NOUN	NNS	Number=Plur	_	_	_	_
8	in	in	ADP	IN	_	_	_	_	_
9	their	they	PRON	PRP$	Number=Plur|Person=3|Poss=Yes|PronType=Prs	_	_	_	_
10	reversible	reversible	ADJ	JJ	Degree=Pos	_	_	_	_
11	transformation	transformation	NOUN	NN	Number=Sing	_	_	_	_
12	such	such	ADJ	JJ	Degree=Pos	_	_	_	_
13	that	that	SCONJ	IN	_	_	_	_	_
14	they	they	PRON	PRP	Case=Nom|Number=Plur|Person=3|PronType=Prs	_	_	_	_
15	become	become	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
16	immortalised	immortalised	ADJ	JJ	Degree=Pos	_	_	_	_
17	and	and	CCONJ	CC	_	_	_	_	_
18	metastatic	metastatic	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
19	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1682
# text = The present study describes parasite-induced changes in host cell gene expression which have a direct bearing on this transformation process.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	present	present	ADJ	JJ	Degree=Pos	_	_	_	_
3	study	study	NOUN	NN	Number=Sing	_	_	_	_
4	describes	describe	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
5	parasite	parasite	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
6	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
7	induced	induce	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
8	changes	change	NOUN	NNS	Number=Plur	_	_	_	_
9	in	in	ADP	IN	_	_	_	_	_
10	host	host	NOUN	NN	Number=Sing	_	_	_	_
11	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
12	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
13	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
14	which	which	PRON	WDT	PronType=Rel	_	_	_	_
15	have	have	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
16	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
17	direct	direct	ADJ	JJ	Degree=Pos	_	_	_	_
18	bearing	bearing	NOUN	NN	Number=Sing	_	_	_	_
19	on	on	ADP	IN	_	_	_	_	_
20	this	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
21	transformation	transformation	NOUN	NN	Number=Sing	_	_	_	_
22	process	process	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
23	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1683
# text = T. annulata-infected leucocytes produce a number of novel metalloproteinase activities.
1	T.	T.	PROPN	NNP	Number=Sing	_	_	_	_
2	annulata	annulata	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
3	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
4	infected	infect	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
5	leucocytes	leucocyte	NOUN	NNS	Number=Plur	_	_	_	_
6	produce	produce	VERB	VB	VerbForm=Inf	_	_	_	_
7	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
8	number	number	NOUN	NN	Number=Sing	_	_	_	_
9	of	of	ADP	IN	_	_	_	_	_
10	novel	novel	NOUN	NN	Number=Sing	_	_	_	_
11	metalloproteinase	metalloproteinase	NOUN	NN	Number=Sing	_	_	_	_
12	activities	activity	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
13	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1684
# text = One of these, previously called B1, is a 97-kDa protein which is secreted in large amounts and has been purified from protein-free, conditioned medium.
1	One	one	NUM	CD	NumType=Card	_	_	_	_
2	of	of	ADP	IN	_	_	_	_	_
3	these	these	PRON	DT	Number=Plur|PronType=Dem	_	_	_	SpaceAfter=No
4	,	,	PUNCT	,	_	_	_	_	_
5	previously	previously	ADV	RB	_	_	_	_	_
6	called	call	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
7	B1	b1	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
8	,	,	PUNCT	,	_	_	_	_	_
9	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
10	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
11	97	97	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
12	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
13	kDa	kDa	NOUN	NN	Number=Sing	_	_	_	_
14	protein	protein	NOUN	NN	Number=Sing	_	_	_	_
15	which	which	PRON	WDT	PronType=Rel	_	_	_	_
16	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
17	secreted	secret	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
18	in	in	ADP	IN	_	_	_	_	_
19	large	large	ADJ	JJ	Degree=Pos	_	_	_	_
20	amounts	amount	NOUN	NNS	Number=Plur	_	_	_	_
21	and	and	CCONJ	CC	_	_	_	_	_
22	has	have	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
23	been	be	AUX	VBN	Tense=Past|VerbForm=Part	_	_	_	_
24	purified	purify	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
25	from	from	ADP	IN	_	_	_	_	_
26	protein-	protein-	SYM	NFP	_	_	_	_	SpaceAfter=No
27	free	free	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
28	,	,	PUNCT	,	_	_	_	_	_
29	conditioned	condition	ADJ	JJ	Degree=Pos	_	_	_	_
30	medium	medium	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
31	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1685
# text = An antiserum to this enzyme was used to isolate a cDNA clone.
1	An	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
2	antiserum	antiserum	NOUN	NN	Number=Sing	_	_	_	_
3	to	to	ADP	IN	_	_	_	_	_
4	this	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
5	enzyme	enzyme	NOUN	NN	Number=Sing	_	_	_	_
6	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
7	used	use	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
8	to	to	PART	TO	_	_	_	_	_
9	isolate	isolate	VERB	VB	VerbForm=Inf	_	_	_	_
10	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
11	cDNA	cDNa	NOUN	NN	Number=Sing	_	_	_	_
12	clone	clone	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
13	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1686
# text = The predicted protein sequence of B1 is 81% identical to human matrix metalloproteinase 9 (MMP9), demonstrating that it is the bovine homologue of this enzyme.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	predicted	predict	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
3	protein	protein	NOUN	NN	Number=Sing	_	_	_	_
4	sequence	sequence	NOUN	NN	Number=Sing	_	_	_	_
5	of	of	ADP	IN	_	_	_	_	_
6	B1	B1	PROPN	NNP	Number=Sing	_	_	_	_
7	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
8	81	81	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
9	%	%	SYM	NN	Number=Sing	_	_	_	_
10	identical	identical	ADJ	JJ	Degree=Pos	_	_	_	_
11	to	to	ADP	IN	_	_	_	_	_
12	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
13	matrix	matrix	NOUN	NN	Number=Sing	_	_	_	_
14	metalloproteinase	metalloproteinase	NOUN	NN	Number=Sing	_	_	_	_
15	9	9	NUM	CD	NumType=Card	_	_	_	_
16	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
17	MMP9	Mmp9	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
18	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
19	,	,	PUNCT	,	_	_	_	_	_
20	demonstrating	demonstrat	VERB	VBG	VerbForm=Ger	_	_	_	_
21	that	that	SCONJ	IN	_	_	_	_	_
22	it	it	PRON	PRP	Case=Nom|Gender=Neut|Number=Sing|Person=3|PronType=Prs	_	_	_	_
23	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
24	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
25	bovine	bovine	NOUN	NN	Number=Sing	_	_	_	_
26	homologue	homologue	NOUN	NN	Number=Sing	_	_	_	_
27	of	of	ADP	IN	_	_	_	_	_
28	this	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
29	enzyme	enzyme	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
30	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1687
# text = RNAase protection assays demonstrated that the MMP9 activity, unique to infected cells, is due to increased MMP9 mRNA levels.
1	RNAase	RNAase	NOUN	NN	Number=Sing	_	_	_	_
2	protection	protection	NOUN	NN	Number=Sing	_	_	_	_
3	assays	assays	NOUN	NNS	Number=Plur	_	_	_	_
4	demonstrated	demonstrate	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
5	that	that	SCONJ	IN	_	_	_	_	_
6	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
7	MMP9	MMP9	PROPN	NNP	Number=Sing	_	_	_	_
8	activity	activity	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
9	,	,	PUNCT	,	_	_	_	_	_
10	unique	unique	ADJ	JJ	Degree=Pos	_	_	_	_
11	to	to	ADP	IN	_	_	_	_	_
12	infected	infect	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
13	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
14	,	,	PUNCT	,	_	_	_	_	_
15	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
16	due	due	ADP	IN	_	_	_	_	_
17	to	to	ADP	IN	_	_	_	_	_
18	increased	increase	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
19	MMP9	MMP9	PROPN	NNP	Number=Sing	_	_	_	_
20	mRNA	mRNA	PROPN	NNP	Number=Sing	_	_	_	_
21	levels	level	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
22	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1688
# text = We also assayed the levels of transcription factor AP-1 and demonstrated that it was constitutively present in increased amounts in Theileria-infected cells.
1	We	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
2	also	also	ADV	RB	_	_	_	_	_
3	assayed	assay	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
4	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
5	levels	level	NOUN	NNS	Number=Plur	_	_	_	_
6	of	of	ADP	IN	_	_	_	_	_
7	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
8	factor	factor	NOUN	NN	Number=Sing	_	_	_	_
9	AP	ap	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
10	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
11	1	1	NUM	CD	NumType=Card	_	_	_	_
12	and	and	CCONJ	CC	_	_	_	_	_
13	demonstrated	demonstrate	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
14	that	that	SCONJ	IN	_	_	_	_	_
15	it	it	PRON	PRP	Case=Nom|Gender=Neut|Number=Sing|Person=3|PronType=Prs	_	_	_	_
16	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
17	constitutively	constitutively	ADV	RB	_	_	_	_	_
18	present	present	ADJ	JJ	Degree=Pos	_	_	_	_
19	in	in	ADP	IN	_	_	_	_	_
20	increased	increase	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
21	amounts	amount	NOUN	NNS	Number=Plur	_	_	_	_
22	in	in	ADP	IN	_	_	_	_	_
23	Theileria	Theileria	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
24	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
25	infected	infect	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
26	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
27	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1689
# text = In addition we assayed the level of mRNA encoding c-Fos, a common component of AP-1 and observed that it was indeed up-regulated in infected cells.
1	In	in	ADP	IN	_	_	_	_	_
2	addition	addition	NOUN	NN	Number=Sing	_	_	_	_
3	we	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
4	assayed	assay	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
5	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
6	level	level	NOUN	NN	Number=Sing	_	_	_	_
7	of	of	ADP	IN	_	_	_	_	_
8	mRNA	mRNA	PROPN	NNP	Number=Sing	_	_	_	_
9	encoding	encod	VERB	VBG	VerbForm=Ger	_	_	_	_
10	c-	c-	SYM	NFP	_	_	_	_	SpaceAfter=No
11	Fos	Fos	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
12	,	,	PUNCT	,	_	_	_	_	_
13	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
14	common	common	ADJ	JJ	Degree=Pos	_	_	_	_
15	component	component	NOUN	NN	Number=Sing	_	_	_	_
16	of	of	ADP	IN	_	_	_	_	_
17	AP	Ap	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
18	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
19	1	1	NUM	CD	NumType=Card	_	_	_	_
20	and	and	CCONJ	CC	_	_	_	_	_
21	observed	observe	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
22	that	that	SCONJ	IN	_	_	_	_	_
23	it	it	PRON	PRP	Case=Nom|Gender=Neut|Number=Sing|Person=3|PronType=Prs	_	_	_	_
24	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
25	indeed	indeed	ADV	RB	_	_	_	_	_
26	up	up	ADV	RB	_	_	_	_	SpaceAfter=No
27	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
28	regulated	regulate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
29	in	in	ADP	IN	_	_	_	_	_
30	infected	infect	ADJ	JJ	Degree=Pos	_	_	_	_
31	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
32	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1690
# text = Since AP-1 is implicated in the control of the cell cycle, and MMP9 can confer metastatic properties, these results are of considerable significance with respect to the transformed phenotype induced by Theileria infection.
1	Since	since	ADP	IN	_	_	_	_	_
2	AP	ap	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
3	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
4	1	1	NUM	CD	NumType=Card	_	_	_	_
5	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
6	implicated	implicate	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
7	in	in	ADP	IN	_	_	_	_	_
8	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
9	control	control	NOUN	NN	Number=Sing	_	_	_	_
10	of	of	ADP	IN	_	_	_	_	_
11	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
12	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
13	cycle	cycle	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
14	,	,	PUNCT	,	_	_	_	_	_
15	and	and	CCONJ	CC	_	_	_	_	_
16	MMP9	MMP9	PROPN	NNP	Number=Sing	_	_	_	_
17	can	can	AUX	MD	VerbForm=Fin	_	_	_	_
18	confer	confer	VERB	VB	VerbForm=Inf	_	_	_	_
19	metastatic	metastatic	ADJ	JJ	Degree=Pos	_	_	_	_
20	properties	property	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
21	,	,	PUNCT	,	_	_	_	_	_
22	these	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
23	results	result	NOUN	NNS	Number=Plur	_	_	_	_
24	are	be	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
25	of	of	ADP	IN	_	_	_	_	_
26	considerable	considerable	ADJ	JJ	Degree=Pos	_	_	_	_
27	significance	significance	NOUN	NN	Number=Sing	_	_	_	_
28	with	with	ADP	IN	_	_	_	_	_
29	respect	respect	NOUN	NN	Number=Sing	_	_	_	_
30	to	to	ADP	IN	_	_	_	_	_
31	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
32	transformed	transform	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
33	phenotype	phenotype	NOUN	NN	Number=Sing	_	_	_	_
34	induced	induce	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
35	by	by	ADP	IN	_	_	_	_	_
36	Theileria	Theileria	PROPN	NNP	Number=Sing	_	_	_	_
37	infection	infection	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
38	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 1691
# text = Document 0030036 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	0030036	0030036	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 1692
# text = Tyloxapol inhibits NF-kappa B and cytokine release, scavenges HOCI, and reduces viscosity of cystic fibrosis sputum.
1	Tyloxapol	Tyloxapol	PROPN	NNP	Number=Sing	_	_	_	_
2	inhibits	inhibit	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
3	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
4	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
5	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_
6	B	b	NOUN	NN	Number=Sing	_	_	_	_
7	and	and	CCONJ	CC	_	_	_	_	_
8	cytokine	cytokine	NOUN	NN	Number=Sing	_	_	_	_
9	release	release	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
10	,	,	PUNCT	,	_	_	_	_	_
11	scavenges	scavenge	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
12	HOCI	HOCI	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
13	,	,	PUNCT	,	_	_	_	_	_
14	and	and	CCONJ	CC	_	_	_	_	_
15	reduces	reduce	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
16	viscosity	viscosity	NOUN	NN	Number=Sing	_	_	_	_
17	of	of	ADP	IN	_	_	_	_	_
18	cystic	cystic	ADJ	JJ	Degree=Pos	_	_	_	_
19	fibrosis	fibrosis	NOUN	NN	Number=Sing	_	_	_	_
20	sputum	sputum	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
21	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 1693
# text = Cystic fibrosis (CF) patients develop progressive cytokine-mediated inflammatory lung disease, with abundant production of thick, tenacious, protease- and oxidant-rich purulent airway secretions that are difficult to clear even with physiotherapy.
1	Cystic	Cystic	ADJ	JJ	Degree=Pos	_	_	_	_
2	fibrosis	fibrosis	NOUN	NN	Number=Sing	_	_	_	_
3	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
4	CF	CF	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
5	)	)	PUNCT	-RRB-	_	_	_	_	_
6	patients	patient	NOUN	NNS	Number=Plur	_	_	_	_
7	develop	develop	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
8	progressive	progressive	ADJ	JJ	Degree=Pos	_	_	_	_
9	cytokine	cytokine	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
10	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
11	mediated	mediate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
12	inflammatory	inflammatory	ADJ	JJ	Degree=Pos	_	_	_	_
13	lung	lung	NOUN	NN	Number=Sing	_	_	_	_
14	disease	disease	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
15	,	,	PUNCT	,	_	_	_	_	_
16	with	with	ADP	IN	_	_	_	_	_
17	abundant	abundant	ADJ	JJ	Degree=Pos	_	_	_	_
18	production	production	NOUN	NN	Number=Sing	_	_	_	_
19	of	of	ADP	IN	_	_	_	_	_
20	thick	thick	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
21	,	,	PUNCT	,	_	_	_	_	_
22	tenacious	tenacious	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
23	,	,	PUNCT	,	_	_	_	_	_
24	protease	protease	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
25	-	-	PUNCT	,	_	_	_	_	_
26	and	and	CCONJ	CC	_	_	_	_	_
27	oxidant	oxidant	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
28	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
29	rich	rich	ADJ	JJ	Degree=Pos	_	_	_	_
30	purulent	purulent	ADJ	JJ	Degree=Pos	_	_	_	_
31	airway	airway	NOUN	NN	Number=Sing	_	_	_	_
32	secretions	secretion	NOUN	NNS	Number=Plur	_	_	_	_
33	that	that	PRON	WDT	PronType=Rel	_	_	_	_
34	are	be	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
35	difficult	difficult	ADJ	JJ	Degree=Pos	_	_	_	_
36	to	to	PART	TO	_	_	_	_	_
37	clear	clear	VERB	VB	VerbForm=Inf	_	_	_	_
38	even	even	ADV	RB	_	_	_	_	_
39	with	with	ADP	IN	_	_	_	_	_
40	physiotherapy	physiotherapy	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
41	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1694
# text = In the search for a potential treatment, we have tested tyloxapol, an alkylaryl polyether alcohol polymer detergent previously used as a mucolytic agent in adult chronic bronchitis.
1	In	in	ADP	IN	_	_	_	_	_
2	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
3	search	search	NOUN	NN	Number=Sing	_	_	_	_
4	for	for	ADP	IN	_	_	_	_	_
5	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
6	potential	potential	ADJ	JJ	Degree=Pos	_	_	_	_
7	treatment	treatment	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
8	,	,	PUNCT	,	_	_	_	_	_
9	we	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
10	have	have	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
11	tested	test	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
12	tyloxapol	tyloxapol	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
13	,	,	PUNCT	,	_	_	_	_	_
14	an	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
15	alkylaryl	alkylaryl	ADJ	JJ	Degree=Pos	_	_	_	_
16	polyether	polyether	NOUN	NN	Number=Sing	_	_	_	_
17	alcohol	alcohol	NOUN	NN	Number=Sing	_	_	_	_
18	polymer	polymer	NOUN	NN	Number=Sing	_	_	_	_
19	detergent	detergent	NOUN	NN	Number=Sing	_	_	_	_
20	previously	previously	ADV	RB	_	_	_	_	_
21	used	use	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
22	as	as	ADP	IN	_	_	_	_	_
23	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
24	mucolytic	mucolytic	ADJ	JJ	Degree=Pos	_	_	_	_
25	agent	agent	NOUN	NN	Number=Sing	_	_	_	_
26	in	in	ADP	IN	_	_	_	_	_
27	adult	adult	NOUN	NN	Number=Sing	_	_	_	_
28	chronic	chronic	NOUN	NN	Number=Sing	_	_	_	_
29	bronchitis	bronchitis	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
30	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1695
# text = Tyloxapol inhibits activation of the transcription factor nuclear factor-kappa B (NK-kappa B), reduces resting secretion of the cytokine interleukin-8 (IL-8) in cultured human monocytes, and inhibits lipopolysaccharide (LPS)-stimulated release of tumor necrosis factor-alpha (TNF-alpha), IL-1 beta, IL-6, IL-8, granulocyte-macrophage colony-stimulating factor (GM-CSF), and the eiconsanoids thromboxane A2 and leukotriene B4 (LTB4).
1	Tyloxapol	Tyloxapol	ADJ	JJ	Degree=Pos	_	_	_	_
2	inhibits	inhibits	NOUN	NNS	Number=Plur	_	_	_	_
3	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
4	of	of	ADP	IN	_	_	_	_	_
5	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
6	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
7	factor	factor	NOUN	NN	Number=Sing	_	_	_	_
8	nuclear	nuclear	ADJ	JJ	Degree=Pos	_	_	_	_
9	factor	factor	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
10	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
11	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_
12	B	b	NOUN	NN	Number=Sing	_	_	_	_
13	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
14	NK	Nk	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
15	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
16	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_
17	B	b	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
18	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
19	,	,	PUNCT	,	_	_	_	_	_
20	reduces	reduce	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
21	resting	rest	VERB	VBG	VerbForm=Ger	_	_	_	_
22	secretion	secretion	NOUN	NN	Number=Sing	_	_	_	_
23	of	of	ADP	IN	_	_	_	_	_
24	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
25	cytokine	cytokine	NOUN	NN	Number=Sing	_	_	_	_
26	interleukin	interleukin	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
27	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
28	8	8	NUM	CD	NumType=Card	_	_	_	_
29	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
30	IL	Il	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
31	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
32	8	8	X	LS	_	_	_	_	SpaceAfter=No
33	)	)	PUNCT	-RRB-	_	_	_	_	_
34	in	in	ADP	IN	_	_	_	_	_
35	cultured	culture	ADJ	JJ	Degree=Pos	_	_	_	_
36	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
37	monocytes	monocyte	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
38	,	,	PUNCT	,	_	_	_	_	_
39	and	and	CCONJ	CC	_	_	_	_	_
40	inhibits	inhibits	PRON	PRP$	Gender=Neut|Number=Sing|Person=3|Poss=Yes|PronType=Prs	_	_	_	_
41	lipopolysaccharide	lipopolysaccharide	NOUN	NN	Number=Sing	_	_	_	_
42	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
43	LPS	LPS	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
44	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
45	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
46	stimulated	stimulate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
47	release	release	NOUN	NN	Number=Sing	_	_	_	_
48	of	of	ADP	IN	_	_	_	_	_
49	tumor	tumor	NOUN	NN	Number=Sing	_	_	_	_
50	necrosis	necrosis	NOUN	NN	Number=Sing	_	_	_	_
51	factor	factor	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
52	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
53	alpha	alpha	NOUN	NN	Number=Sing	_	_	_	_
54	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
55	TNF	Tnf	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
56	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
57	alpha	alpha	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
58	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
59	,	,	PUNCT	,	_	_	_	_	_
60	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
61	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
62	1	1	NUM	CD	NumType=Card	_	_	_	_
63	beta	beta	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
64	,	,	PUNCT	,	_	_	_	_	_
65	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
66	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
67	6	6	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
68	,	,	PUNCT	,	_	_	_	_	_
69	IL	Il	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
70	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
71	8	8	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
72	,	,	PUNCT	,	_	_	_	_	_
73	granulocyte	granulocyte	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
74	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
75	macrophage	macrophage	NOUN	NN	Number=Sing	_	_	_	_
76	colony	colony	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
77	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
78	stimulating	stimulating	VERB	VBG	VerbForm=Ger	_	_	_	_
79	factor	factor	NOUN	NN	Number=Sing	_	_	_	_
80	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
81	GM	GM	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
82	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
83	CSF	CSF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
84	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
85	,	,	PUNCT	,	_	_	_	_	_
86	and	and	CCONJ	CC	_	_	_	_	_
87	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
88	eiconsanoids	eiconsanoid	NOUN	NNS	Number=Plur	_	_	_	_
89	thromboxane	thromboxane	NOUN	NN	Number=Sing	_	_	_	_
90	A2	a2	NOUN	NN	Number=Sing	_	_	_	_
91	and	and	CCONJ	CC	_	_	_	_	_
92	leukotriene	leukotriene	NOUN	NN	Number=Sing	_	_	_	_
93	B4	B4	PROPN	NNP	Number=Sing	_	_	_	_
94	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
95	LTB4	LTB4	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
96	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
97	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1696
# text = We have previously shown that tyloxapol is a potent antioxidant for hydroxyl radicals ( OH).
1	We	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
2	have	have	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
3	previously	previously	ADV	RB	_	_	_	_	_
4	shown	show	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
5	that	that	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
6	tyloxapol	tyloxapol	NOUN	NN	Number=Sing	_	_	_	_
7	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
8	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
9	potent	potent	NOUN	NN	Number=Sing	_	_	_	_
10	antioxidant	antioxidant	NOUN	NN	Number=Sing	_	_	_	_
11	for	for	ADP	IN	_	_	_	_	_
12	hydroxyl	hydroxyl	NOUN	NN	Number=Sing	_	_	_	_
13	radicals	radical	NOUN	NNS	Number=Plur	_	_	_	_
14	(	(	PUNCT	-LRB-	_	_	_	_	_
15	OH	oh	INTJ	UH	_	_	_	_	SpaceAfter=No
16	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
17	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1697
# text = Tyloxapol (0.05 to 0.1% wt/vol) effectively scavenges the oxidant hypochlorous acid (HOCl; 1 to 7.5 mM) in vitro, and protects from HOCl-mediated lung injury in rats.
1	Tyloxapol	Tyloxapol	PROPN	NNP	Number=Sing	_	_	_	_
2	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
3	0.05	0.05	NUM	CD	NumType=Card	_	_	_	_
4	to	to	ADP	IN	_	_	_	_	_
5	0.1	0.1	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
6	%	%	SYM	NN	Number=Sing	_	_	_	_
7	wt	wt	ADJ	JJS	Degree=Sup	_	_	_	SpaceAfter=No
8	/vol	/vol	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
9	)	)	PUNCT	-RRB-	_	_	_	_	_
10	effectively	effectively	ADV	RB	_	_	_	_	_
11	scavenges	scavenge	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
12	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
13	oxidant	oxidant	ADJ	JJ	Degree=Pos	_	_	_	_
14	hypochlorous	hypochlorous	ADJ	JJ	Degree=Pos	_	_	_	_
15	acid	acid	NOUN	NN	Number=Sing	_	_	_	_
16	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
17	HOCl	HOCl	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
18	;	;	PUNCT	,	_	_	_	_	_
19	1	1	NUM	CD	NumType=Card	_	_	_	_
20	to	to	ADP	IN	_	_	_	_	_
21	7.5	7.5	NUM	CD	NumType=Card	_	_	_	_
22	mM	mm	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
23	)	)	PUNCT	-RRB-	_	_	_	_	_
24	in	in	ADP	IN	_	_	_	_	_
25	vitro	vitro	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
26	,	,	PUNCT	,	_	_	_	_	_
27	and	and	CCONJ	CC	_	_	_	_	_
28	protects	protect	NOUN	NNS	Number=Plur	_	_	_	_
29	from	from	ADP	IN	_	_	_	_	_
30	HOCl	HOCl	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
31	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
32	mediated	mediate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
33	lung	lung	NOUN	NN	Number=Sing	_	_	_	_
34	injury	injury	NOUN	NN	Number=Sing	_	_	_	_
35	in	in	ADP	IN	_	_	_	_	_
36	rats	rat	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
37	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1698
# text = Tyloxapol also reduces the viscosity of CF sputum (from 463 +/- 133 to 128 +/- 52 centipoise).
1	Tyloxapol	Tyloxapol	PROPN	NNP	Number=Sing	_	_	_	_
2	also	also	ADV	RB	_	_	_	_	_
3	reduces	reduce	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
4	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
5	viscosity	viscosity	NOUN	NN	Number=Sing	_	_	_	_
6	of	of	ADP	IN	_	_	_	_	_
7	CF	CF	PROPN	NNP	Number=Sing	_	_	_	_
8	sputum	sputum	NOUN	NN	Number=Sing	_	_	_	_
9	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
10	from	from	ADP	IN	_	_	_	_	_
11	463	463	NUM	CD	NumType=Card	_	_	_	_
12	+/-	+/-	SYM	SYM	_	_	_	_	_
13	133	133	NUM	CD	NumType=Card	_	_	_	_
14	to	to	ADP	IN	_	_	_	_	_
15	128	128	NUM	CD	NumType=Card	_	_	_	_
16	+/-	+/-	SYM	SYM	_	_	_	_	_
17	52	52	NUM	CD	NumType=Card	_	_	_	_
18	centipoise	centipoise	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
19	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
20	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1699
# text = We conclude that tyloxapol is potentially useful as a new antiinflammatory therapy for CF lung disease, and could possibly promote clearance of secretions in the CF airway.
1	We	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
2	conclude	conclude	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
3	that	that	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
4	tyloxapol	tyloxapol	NOUN	NN	Number=Sing	_	_	_	_
5	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
6	potentially	potentially	ADV	RB	_	_	_	_	_
7	useful	useful	ADJ	JJ	Degree=Pos	_	_	_	_
8	as	as	ADP	IN	_	_	_	_	_
9	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
10	new	new	ADJ	JJ	Degree=Pos	_	_	_	_
11	antiinflammatory	antiinflammatory	ADJ	JJ	Degree=Pos	_	_	_	_
12	therapy	therapy	NOUN	NN	Number=Sing	_	_	_	_
13	for	for	ADP	IN	_	_	_	_	_
14	CF	CF	PROPN	NNP	Number=Sing	_	_	_	_
15	lung	lung	NOUN	NN	Number=Sing	_	_	_	_
16	disease	disease	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
17	,	,	PUNCT	,	_	_	_	_	_
18	and	and	CCONJ	CC	_	_	_	_	_
19	could	could	AUX	MD	VerbForm=Fin	_	_	_	_
20	possibly	possibly	ADV	RB	_	_	_	_	_
21	promote	promote	VERB	VB	VerbForm=Inf	_	_	_	_
22	clearance	clearance	NOUN	NN	Number=Sing	_	_	_	_
23	of	of	ADP	IN	_	_	_	_	_
24	secretions	secretion	NOUN	NNS	Number=Plur	_	_	_	_
25	in	in	ADP	IN	_	_	_	_	_
26	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
27	CF	CF	PROPN	NNP	Number=Sing	_	_	_	_
28	airway	airway	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
29	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 1700
# text = Document 0030039 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	0030039	0030039	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 1701
# text = The murine BCL6 gene is induced in activated lymphocytes as an immediate early gene.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	murine	murine	NOUN	NN	Number=Sing	_	_	_	_
3	BCL6	Bcl6	NOUN	NN	Number=Sing	_	_	_	_
4	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
5	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
6	induced	induce	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
7	in	in	ADP	IN	_	_	_	_	_
8	activated	activate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
9	lymphocytes	lymphocyte	NOUN	NNS	Number=Plur	_	_	_	_
10	as	as	ADP	IN	_	_	_	_	_
11	an	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
12	immediate	immediate	ADJ	JJ	Degree=Pos	_	_	_	_
13	early	early	ADJ	JJ	Degree=Pos	_	_	_	_
14	gene	gene	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
15	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 1702
# text = The chromosomal translocation involving 3q27 is often detected in human B-cell lymphomas, especially diffuse lymphomas with a large-cell component.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	chromosomal	chromosomal	NOUN	NN	Number=Sing	_	_	_	_
3	translocation	translocation	NOUN	NN	Number=Sing	_	_	_	_
4	involving	involve	VERB	VBG	VerbForm=Ger	_	_	_	_
5	3q27	3q27	NUM	CD	NumType=Card	_	_	_	_
6	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
7	often	often	ADV	RB	_	_	_	_	_
8	detected	detect	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
9	in	in	ADP	IN	_	_	_	_	_
10	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
11	B	b	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
12	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
13	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
14	lymphomas	lymphoma	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
15	,	,	PUNCT	,	_	_	_	_	_
16	especially	especially	ADV	RB	_	_	_	_	_
17	diffuse	diffuse	ADJ	JJ	Degree=Pos	_	_	_	_
18	lymphomas	lymphoma	NOUN	NNS	Number=Plur	_	_	_	_
19	with	with	ADP	IN	_	_	_	_	_
20	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
21	large	large	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
22	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
23	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
24	component	component	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
25	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1703
# text = The BCL6 gene has been isolated from the chromosomal breakpoint in these lymphomas.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	BCL6	Bcl6	PROPN	NNP	Number=Sing	_	_	_	_
3	gene	gene	PROPN	NNP	Number=Sing	_	_	_	_
4	has	have	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
5	been	be	AUX	VBN	Tense=Past|VerbForm=Part	_	_	_	_
6	isolated	isolate	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
7	from	from	ADP	IN	_	_	_	_	_
8	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
9	chromosomal	chromosomal	ADJ	JJ	Degree=Pos	_	_	_	_
10	breakpoint	breakpoint	NOUN	NN	Number=Sing	_	_	_	_
11	in	in	ADP	IN	_	_	_	_	_
12	these	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
13	lymphomas	lymphoma	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
14	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1704
# text = Here we cloned the murine BCL6 (mBCL6) cDNA from the muscle cDNA library using the human BCL6 (hBCL6) cDNA as a probe.
1	Here	here	ADV	RB	PronType=Dem	_	_	_	_
2	we	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
3	cloned	clon	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
4	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
5	murine	murine	NOUN	NN	Number=Sing	_	_	_	_
6	BCL6	Bcl6	PROPN	NNP	Number=Sing	_	_	_	_
7	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
8	mBCL6	mBCL6	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
9	)	)	PUNCT	-RRB-	_	_	_	_	_
10	cDNA	cDNa	NOUN	NN	Number=Sing	_	_	_	_
11	from	from	ADP	IN	_	_	_	_	_
12	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
13	muscle	muscle	NOUN	NN	Number=Sing	_	_	_	_
14	cDNA	cDNa	NOUN	NN	Number=Sing	_	_	_	_
15	library	library	NOUN	NN	Number=Sing	_	_	_	_
16	using	use	VERB	VBG	VerbForm=Ger	_	_	_	_
17	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
18	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
19	BCL6	Bcl6	NOUN	NN	Number=Sing	_	_	_	_
20	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
21	hBCL6	hBCL6	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
22	)	)	PUNCT	-RRB-	_	_	_	_	_
23	cDNA	cDNa	NOUN	NN	Number=Sing	_	_	_	_
24	as	as	ADP	IN	_	_	_	_	_
25	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
26	probe	probe	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
27	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1705
# text = The predicted amino acid sequence was 95% identical to that of hBCL6.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	predicted	predict	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
3	amino	amino	DET	DT	_	_	_	_	_
4	acid	acid	ADJ	JJ	Degree=Pos	_	_	_	_
5	sequence	sequence	NOUN	NN	Number=Sing	_	_	_	_
6	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
7	95	95	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
8	%	%	SYM	NN	Number=Sing	_	_	_	_
9	identical	identical	ADJ	JJ	Degree=Pos	_	_	_	_
10	to	to	ADP	IN	_	_	_	_	_
11	that	that	PRON	DT	Number=Sing|PronType=Dem	_	_	_	_
12	of	of	ADP	IN	_	_	_	_	_
13	hBCL6	hbcl6	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
14	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1706
# text = It contains six repeats of the Kruppel-like zinc-finger motif that are completely identical to those of hBCL6, indicating that the BCL6 gene is well conserved between humans and mice.
1	It	it	PRON	PRP	Case=Nom|Gender=Neut|Number=Sing|Person=3|PronType=Prs	_	_	_	_
2	contains	contain	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
3	six	six	NUM	CD	NumType=Card	_	_	_	_
4	repeats	repeat	NOUN	NNS	Number=Plur	_	_	_	_
5	of	of	ADP	IN	_	_	_	_	_
6	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
7	Kruppel	Kruppel	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
8	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
9	like	like	ADJ	JJ	Degree=Pos	_	_	_	_
10	zinc	zinc	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
11	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
12	finger	finger	NOUN	NN	Number=Sing	_	_	_	_
13	motif	motif	NOUN	NN	Number=Sing	_	_	_	_
14	that	that	PRON	WDT	PronType=Rel	_	_	_	_
15	are	be	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
16	completely	completely	ADV	RB	_	_	_	_	_
17	identical	identical	ADJ	JJ	Degree=Pos	_	_	_	_
18	to	to	ADP	IN	_	_	_	_	_
19	those	those	PRON	DT	Number=Plur|PronType=Dem	_	_	_	_
20	of	of	ADP	IN	_	_	_	_	_
21	hBCL6	hBCL6	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
22	,	,	PUNCT	,	_	_	_	_	_
23	indicating	indicate	VERB	VBG	VerbForm=Ger	_	_	_	_
24	that	that	SCONJ	IN	_	_	_	_	_
25	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
26	BCL6	Bcl6	PROPN	NNP	Number=Sing	_	_	_	_
27	gene	gene	PROPN	NNP	Number=Sing	_	_	_	_
28	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
29	well	well	ADV	RB	Degree=Pos	_	_	_	_
30	conserved	conserve	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
31	between	between	ADP	IN	_	_	_	_	_
32	humans	human	NOUN	NNS	Number=Plur	_	_	_	_
33	and	and	CCONJ	CC	_	_	_	_	_
34	mice	mouse	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
35	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1707
# text = Expression of the mBCL6 gene was ubiquitously detected in adult mouse tissues including lymphatic organs.
1	Expression	expression	NOUN	NN	Number=Sing	_	_	_	_
2	of	of	ADP	IN	_	_	_	_	_
3	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
4	mBCL6	mbcl6	PROPN	NNP	Number=Sing	_	_	_	_
5	gene	gene	PROPN	NNP	Number=Sing	_	_	_	_
6	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
7	ubiquitously	ubiquitously	ADV	RB	_	_	_	_	_
8	detected	detect	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
9	in	in	ADP	IN	_	_	_	_	_
10	adult	adult	NOUN	NN	Number=Sing	_	_	_	_
11	mouse	mouse	NOUN	NN	Number=Sing	_	_	_	_
12	tissues	tissue	NOUN	NNS	Number=Plur	_	_	_	_
13	including	include	VERB	VBG	VerbForm=Ger	_	_	_	_
14	lymphatic	lymphatic	ADJ	JJ	Degree=Pos	_	_	_	_
15	organs	organ	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
16	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1708
# text = Furthermore, it was induced in lymphocytes activated with phorbol ester and Ca2+ ionophore within 30 min after stimulation.
1	Furthermore	furthermore	ADV	RB	_	_	_	_	SpaceAfter=No
2	,	,	PUNCT	,	_	_	_	_	_
3	it	it	PRON	PRP	Case=Nom|Gender=Neut|Number=Sing|Person=3|PronType=Prs	_	_	_	_
4	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
5	induced	induce	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
6	in	in	ADP	IN	_	_	_	_	_
7	lymphocytes	lymphocyte	NOUN	NNS	Number=Plur	_	_	_	_
8	activated	activate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
9	with	with	ADP	IN	_	_	_	_	_
10	phorbol	phorbol	NOUN	NN	Number=Sing	_	_	_	_
11	ester	ester	NOUN	NN	Number=Sing	_	_	_	_
12	and	and	CCONJ	CC	_	_	_	_	_
13	Ca2	ca2	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
14	+	+	SYM	SYM	_	_	_	_	_
15	ionophore	ionophore	ADJ	JJ	Degree=Pos	_	_	_	_
16	within	within	ADP	IN	_	_	_	_	_
17	30	30	NUM	CD	NumType=Card	_	_	_	_
18	min	min	NOUN	NNS	Number=Plur	_	_	_	_
19	after	after	ADP	IN	_	_	_	_	_
20	stimulation	stimulation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
21	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1709
# text = This induction was not inhibited by treatment of the cells with a protein synthesis inhibitor, cycloheximide.
1	This	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
2	induction	induction	NOUN	NN	Number=Sing	_	_	_	_
3	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
4	not	not	PART	RB	_	_	_	_	_
5	inhibited	inhibit	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
6	by	by	ADP	IN	_	_	_	_	_
7	treatment	treatment	NOUN	NN	Number=Sing	_	_	_	_
8	of	of	ADP	IN	_	_	_	_	_
9	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
10	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
11	with	with	ADP	IN	_	_	_	_	_
12	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
13	protein	protein	NOUN	NN	Number=Sing	_	_	_	_
14	synthesis	synthesis	NOUN	NN	Number=Sing	_	_	_	_
15	inhibitor	inhibitor	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
16	,	,	PUNCT	,	_	_	_	_	_
17	cycloheximide	cycloheximide	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
18	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1710
# text = These results suggest that BCL6 plays a role in activated lymphocytes as an immediate early gene.
1	These	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
2	results	result	NOUN	NNS	Number=Plur	_	_	_	_
3	suggest	suggest	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
4	that	that	SCONJ	IN	_	_	_	_	_
5	BCL6	Bcl6	PROPN	NNP	Number=Sing	_	_	_	_
6	plays	play	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
7	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
8	role	role	NOUN	NN	Number=Sing	_	_	_	_
9	in	in	ADP	IN	_	_	_	_	_
10	activated	activated	ADJ	JJ	Degree=Pos	_	_	_	_
11	lymphocytes	lymphocyte	NOUN	NNS	Number=Plur	_	_	_	_
12	as	as	ADP	IN	_	_	_	_	_
13	an	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
14	immediate	immediate	ADJ	JJ	Degree=Pos	_	_	_	_
15	early	early	ADJ	JJ	Degree=Pos	_	_	_	_
16	gene	gene	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
17	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 1711
# text = Document 00300310 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	00300310	00300310	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 1712
# text = Differences in phosphorylation of the IL-2R associated JAK/STAT proteins between HTLV-I(+), IL-2-independent and IL-2-dependent cell lines and uncultured leukemic cells from patients with adult T-cell lymphoma/leukemia.
1	Differences	difference	NOUN	NNS	Number=Plur	_	_	_	_
2	in	in	ADP	IN	_	_	_	_	_
3	phosphorylation	phosphorylation	NOUN	NN	Number=Sing	_	_	_	_
4	of	of	ADP	IN	_	_	_	_	_
5	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
6	IL	Il	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
7	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
8	2R	2r	PROPN	NNP	Number=Sing	_	_	_	_
9	associated	associate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
10	JAK	JAK	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
11	/	/	PUNCT	,	_	_	_	_	SpaceAfter=No
12	STAT	Stat	PROPN	NNP	Number=Sing	_	_	_	_
13	proteins	protein	NOUN	NNS	Number=Plur	_	_	_	_
14	between	between	ADP	IN	_	_	_	_	_
15	HTLV	HTLV	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
16	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
17	I	I	PRON	PRP	Case=Nom|Number=Sing|Person=1|PronType=Prs	_	_	_	SpaceAfter=No
18	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
19	+)	+)	SYM	NFP	_	_	_	_	SpaceAfter=No
20	,	,	PUNCT	,	_	_	_	_	_
21	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
22	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
23	2	2	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
24	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
25	independent	independent	ADJ	JJ	Degree=Pos	_	_	_	_
26	and	and	CCONJ	CC	_	_	_	_	_
27	IL	Il	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
28	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
29	2	2	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
30	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
31	dependent	dependent	ADJ	JJ	Degree=Pos	_	_	_	_
32	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
33	lines	line	NOUN	NNS	Number=Plur	_	_	_	_
34	and	and	CCONJ	CC	_	_	_	_	_
35	uncultured	uncultured	ADJ	JJ	Degree=Pos	_	_	_	_
36	leukemic	leukemic	ADJ	JJ	Degree=Pos	_	_	_	_
37	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
38	from	from	ADP	IN	_	_	_	_	_
39	patients	patient	NOUN	NNS	Number=Plur	_	_	_	_
40	with	with	ADP	IN	_	_	_	_	_
41	adult	adult	NOUN	NN	Number=Sing	_	_	_	_
42	T-	t-	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
43	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
44	lymphoma/	lymphomaith	ADP	IN	Abbr=Yes	_	_	_	SpaceAfter=No
45	leukemia	leukemia	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
46	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 1713
# text = To determine activation status of the IL-2R-associated (Jak/STAT) pathway in the HTLV-I infected cells, we examined tyrosine phosphorylation of Jak3, STAT3, and STAT5 in several HTLV-I(+)
1	To	to	PART	TO	_	_	_	_	_
2	determine	determine	VERB	VB	VerbForm=Inf	_	_	_	_
3	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
4	status	status	NOUN	NN	Number=Sing	_	_	_	_
5	of	of	ADP	IN	_	_	_	_	_
6	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
7	IL-	Il-	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
8	2R-associated	2R-associate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
9	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
10	Jak/	Jakith	X	ADD	_	_	_	_	SpaceAfter=No
11	STAT	STAT	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
12	)	)	PUNCT	-RRB-	_	_	_	_	_
13	pathway	pathway	NOUN	NN	Number=Sing	_	_	_	_
14	in	in	ADP	IN	_	_	_	_	_
15	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
16	HTLV	Htlv	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
17	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
18	I	I	PRON	PRP	Case=Nom|Number=Sing|Person=1|PronType=Prs	_	_	_	_
19	infected	infect	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
20	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
21	,	,	PUNCT	,	_	_	_	_	_
22	we	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
23	examined	examin	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
24	tyrosine	tyrosine	PRON	PRP	_	_	_	_	_
25	phosphorylation	phosphorylation	NOUN	NN	Number=Sing	_	_	_	_
26	of	of	ADP	IN	_	_	_	_	_
27	Jak3	Jak3	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
28	,	,	PUNCT	,	_	_	_	_	_
29	STAT3	STAT3	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
30	,	,	PUNCT	,	_	_	_	_	_
31	and	and	CCONJ	CC	_	_	_	_	_
32	STAT5	STAT5	NUM	CD	NumType=Card	_	_	_	_
33	in	in	ADP	IN	_	_	_	_	_
34	several	several	ADJ	JJ	Degree=Pos	_	_	_	_
35	HTLV	HTLV	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
36	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
37	I	I	PRON	PRP	Case=Nom|Number=Sing|Person=1|PronType=Prs	_	_	_	SpaceAfter=No
38	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
39	+)	+)	SYM	NFP	_	_	_	_	_

# sent_id = 1714
# text = T-cell lines and in uncultured leukemic T cells isolated from patients with adult T-cell lymphoma/leukemia (ATLL).
1	T-	T-	SYM	NFP	_	_	_	_	SpaceAfter=No
2	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
3	lines	line	NOUN	NNS	Number=Plur	_	_	_	_
4	and	and	CCONJ	CC	_	_	_	_	_
5	in	in	ADP	IN	_	_	_	_	_
6	uncultured	uncultured	ADJ	JJ	Degree=Pos	_	_	_	_
7	leukemic	leukemic	ADJ	JJ	Degree=Pos	_	_	_	_
8	T	t	PROPN	NNP	Number=Sing	_	_	_	_
9	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
10	isolated	isolate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
11	from	from	ADP	IN	_	_	_	_	_
12	patients	patient	NOUN	NNS	Number=Plur	_	_	_	_
13	with	with	ADP	IN	_	_	_	_	_
14	adult	adult	NOUN	NN	Number=Sing	_	_	_	_
15	T-	t-	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
16	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
17	lymphoma/leukemia	lymphoma/leukemia	NOUN	NN	Number=Sing	_	_	_	_
18	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
19	ATLL	ATLL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
20	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
21	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1715
# text = Constitutive basal phosphorylation of Jak3 and, usually, STAT3 and STAT5 was detected in all four IL-2-independent cell lines tested, but in none of the three IL-2-dependent cell lines.
1	Constitutive	Constitutive	ADJ	JJ	Degree=Pos	_	_	_	_
2	basal	basal	ADJ	JJ	Degree=Pos	_	_	_	_
3	phosphorylation	phosphorylation	NOUN	NN	Number=Sing	_	_	_	_
4	of	of	ADP	IN	_	_	_	_	_
5	Jak3	Jak3	NUM	CD	NumType=Card	_	_	_	_
6	and	and	CCONJ	CC	_	_	_	_	SpaceAfter=No
7	,	,	PUNCT	,	_	_	_	_	_
8	usually	usually	ADV	RB	_	_	_	_	SpaceAfter=No
9	,	,	PUNCT	,	_	_	_	_	_
10	STAT3	STAT3	NUM	CD	NumType=Card	_	_	_	_
11	and	and	CCONJ	CC	_	_	_	_	_
12	STAT5	stat5	PROPN	NNP	Number=Sing	_	_	_	_
13	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
14	detected	detect	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
15	in	in	ADP	IN	_	_	_	_	_
16	all	all	DET	DT	_	_	_	_	_
17	four	four	NUM	CD	NumType=Card	_	_	_	_
18	IL	Il	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
19	-	-	SYM	SYM	_	_	_	_	SpaceAfter=No
20	2	2	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
21	-independent	-independent	ADJ	JJ	Degree=Pos	_	_	_	_
22	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
23	lines	line	NOUN	NNS	Number=Plur	_	_	_	_
24	tested	tested	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	SpaceAfter=No
25	,	,	PUNCT	,	_	_	_	_	_
26	but	but	CCONJ	CC	_	_	_	_	_
27	in	in	ADP	IN	_	_	_	_	_
28	none	none	NOUN	NN	Number=Sing	_	_	_	_
29	of	of	ADP	IN	_	_	_	_	_
30	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
31	three	three	NUM	CD	NumType=Card	_	_	_	_
32	IL	Il	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
33	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
34	2	2	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
35	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
36	dependent	dependent	ADJ	JJ	Degree=Pos	_	_	_	_
37	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
38	lines	line	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
39	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1716
# text = Similarly, there was no detectable basal phosphorylation of Jak3 and STAT5 in the leukemic cells from ATLL patients (0/8 and 0/3, respectively).
1	Similarly	similarly	ADV	RB	_	_	_	_	SpaceAfter=No
2	,	,	PUNCT	,	_	_	_	_	_
3	there	there	PRON	EX	_	_	_	_	_
4	was	be	VERB	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
5	no	no	DET	DT	_	_	_	_	_
6	detectable	detectable	ADJ	JJ	Degree=Pos	_	_	_	_
7	basal	basal	ADJ	JJ	Degree=Pos	_	_	_	_
8	phosphorylation	phosphorylation	NOUN	NN	Number=Sing	_	_	_	_
9	of	of	ADP	IN	_	_	_	_	_
10	Jak3	Jak3	NUM	CD	NumType=Card	_	_	_	_
11	and	and	CCONJ	CC	_	_	_	_	_
12	STAT5	STAT5	NUM	CD	NumType=Card	_	_	_	_
13	in	in	ADP	IN	_	_	_	_	_
14	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
15	leukemic	leukemic	ADJ	JJ	Degree=Pos	_	_	_	_
16	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
17	from	from	ADP	IN	_	_	_	_	_
18	ATLL	Atll	DET	DT	_	_	_	_	_
19	patients	patient	NOUN	NNS	Number=Plur	_	_	_	_
20	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
21	0/8	0/8	NUM	CD	NumType=Card	_	_	_	_
22	and	and	CCONJ	CC	_	_	_	_	_
23	0/3	0/3	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
24	,	,	PUNCT	,	_	_	_	_	_
25	respectively	respectively	ADV	RB	_	_	_	_	SpaceAfter=No
26	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
27	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1717
# text = However, stimulation with IL-2 resulted in Jak3 and STAT5 phosphorylation in both leukemic ATLL cells and IL-2-dependent lines.
1	However	however	ADV	RB	_	_	_	_	SpaceAfter=No
2	,	,	PUNCT	,	_	_	_	_	_
3	stimulation	stimulation	NOUN	NN	Number=Sing	_	_	_	_
4	with	with	ADP	IN	_	_	_	_	_
5	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
6	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
7	2	2	NUM	CD	NumType=Card	_	_	_	_
8	resulted	result	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
9	in	in	ADP	IN	_	_	_	_	_
10	Jak3	Jak3	NUM	CD	NumType=Card	_	_	_	_
11	and	and	CCONJ	CC	_	_	_	_	_
12	STAT5	STAT5	NUM	CD	NumType=Card	_	_	_	_
13	phosphorylation	phosphorylation	NOUN	NN	Number=Sing	_	_	_	_
14	in	in	ADP	IN	_	_	_	_	_
15	both	both	DET	DT	_	_	_	_	_
16	leukemic	leukemic	ADJ	JJ	Degree=Pos	_	_	_	_
17	ATLL	Atll	NOUN	NN	Number=Sing	_	_	_	_
18	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
19	and	and	CCONJ	CC	_	_	_	_	_
20	IL	Il	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
21	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
22	2	2	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
23	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
24	dependent	dependent	ADJ	JJ	Degree=Pos	_	_	_	_
25	lines	line	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
26	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1718
# text = Furthermore, expression of SHP-1 phosphatase which is a negative regulator of cytokine receptor signaling, was lost in most IL-2 independent cell lines (3/4) but not in the leukemic ATLL cells (0/3).
1	Furthermore	furthermore	ADV	RB	_	_	_	_	SpaceAfter=No
2	,	,	PUNCT	,	_	_	_	_	_
3	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
4	of	of	ADP	IN	_	_	_	_	_
5	SHP	SHP	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
6	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
7	1	1	NUM	CD	NumType=Card	_	_	_	_
8	phosphatase	phosphatase	NOUN	NN	Number=Sing	_	_	_	_
9	which	which	PRON	WDT	PronType=Rel	_	_	_	_
10	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
11	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
12	negative	negative	ADJ	JJ	Degree=Pos	_	_	_	_
13	regulator	regulator	NOUN	NN	Number=Sing	_	_	_	_
14	of	of	ADP	IN	_	_	_	_	_
15	cytokine	cytokine	NOUN	NN	Number=Sing	_	_	_	_
16	receptor	receptor	NOUN	NN	Number=Sing	_	_	_	_
17	signaling	signaling	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
18	,	,	PUNCT	,	_	_	_	_	_
19	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
20	lost	lose	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
21	in	in	ADP	IN	_	_	_	_	_
22	most	most	ADJ	JJS	Degree=Sup	_	_	_	_
23	IL	Il	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
24	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
25	2	2	NUM	CD	NumType=Card	_	_	_	_
26	independent	independent	ADJ	JJ	Degree=Pos	_	_	_	_
27	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
28	lines	line	NOUN	NNS	Number=Plur	_	_	_	_
29	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
30	3/	3/	SYM	SYM	_	_	_	_	SpaceAfter=No
31	4	4	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
32	)	)	PUNCT	-RRB-	_	_	_	_	_
33	but	but	CCONJ	CC	_	_	_	_	_
34	not	not	ADV	RB	_	_	_	_	_
35	in	in	ADP	IN	_	_	_	_	_
36	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
37	leukemic	leukemic	ADJ	JJ	Degree=Pos	_	_	_	_
38	ATLL	Atll	NOUN	NN	Number=Sing	_	_	_	_
39	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
40	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
41	0/3	0/3	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
42	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
43	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1719
# text = Finally, the HTLV-I(+)
1	Finally	finally	ADV	RB	_	_	_	_	SpaceAfter=No
2	,	,	PUNCT	,	_	_	_	_	_
3	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
4	HTLV	Htlv	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
5	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
6	I	I	PRON	PRP	Case=Nom|Number=Sing|Person=1|PronType=Prs	_	_	_	SpaceAfter=No
7	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
8	+)	+)	SYM	NFP	_	_	_	_	_

# sent_id = 1720
# text = T-cell lines (313) but not the control, HTLV-I(-)
1	T-	T-	SYM	NFP	_	_	_	_	SpaceAfter=No
2	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
3	lines	line	NOUN	NNS	Number=Plur	_	_	_	_
4	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
5	313	313	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
6	)	)	PUNCT	-RRB-	_	_	_	_	_
7	but	but	CCONJ	CC	_	_	_	_	_
8	not	not	PART	RB	_	_	_	_	_
9	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
10	control	control	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
11	,	,	PUNCT	,	_	_	_	_	_
12	HTLV	HTLV	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
13	-	-	PUNCT	:	_	_	_	_	SpaceAfter=No
14	I	I	PRON	PRP	Case=Nom|Number=Sing|Person=1|PronType=Prs	_	_	_	SpaceAfter=No
15	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
16	-)	-)	PUNCT	.	_	_	_	_	_

# sent_id = 1721
# text = T-cell lines were resistant to rapamycin and its novel analog RAD.
1	T-	T-	SYM	NFP	_	_	_	_	SpaceAfter=No
2	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
3	lines	line	NOUN	NNS	Number=Plur	_	_	_	_
4	were	be	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
5	resistant	resistant	ADJ	JJ	Degree=Pos	_	_	_	_
6	to	to	PART	TO	_	_	_	_	_
7	rapamycin	rapamycin	VERB	VB	VerbForm=Inf	_	_	_	_
8	and	and	CCONJ	CC	_	_	_	_	_
9	it	it	PRON	PRP	Case=Nom|Gender=Neut|Number=Sing|Person=3|PronType=Prs	_	_	_	SpaceAfter=No
10	s	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
11	novel	novel	VERB	VB	VerbForm=Inf	_	_	_	_
12	analog	analog	ADJ	JJ	Degree=Pos	_	_	_	_
13	RAD	Rad	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
14	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1722
# text = We conclude that (1) HTLV-I infection per se does not result in a constitutive phosphorylation of the Jak3, STAT3, and STAT5 proteins; (2) malignant transformation in at least some cases of ATLL does not require the constitutive, but may require IL-2-induced, activation of the IL-2R Jak/STAT pathway; and (3) there are major differences in T-cell immortalization mechanism(s) which appear to involve SHP-1 and target molecules for rapamycin and RAD.
1	We	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
2	conclude	conclude	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
3	that	that	PRON	DT	Number=Sing|PronType=Dem	_	_	_	_
4	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
5	1	1	X	LS	_	_	_	_	SpaceAfter=No
6	)	)	PUNCT	-RRB-	_	_	_	_	_
7	HTLV	Htlv	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
8	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
9	I	I	PRON	PRP	Case=Nom|Number=Sing|Person=1|PronType=Prs	_	_	_	_
10	infection	infection	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
11	per	per	ADP	IN	_	_	_	_	_
12	se	se	NOUN	NN	Number=Sing	_	_	_	_
13	does	do	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
14	not	not	PART	RB	_	_	_	_	_
15	result	result	VERB	VB	VerbForm=Inf	_	_	_	_
16	in	in	ADP	IN	_	_	_	_	_
17	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
18	constitutive	constitutive	ADJ	JJ	Degree=Pos	_	_	_	_
19	phosphorylation	phosphorylation	NOUN	NN	Number=Sing	_	_	_	_
20	of	of	ADP	IN	_	_	_	_	_
21	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
22	Jak3	Jak3	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
23	,	,	PUNCT	,	_	_	_	_	_
24	STAT3	STAT3	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
25	,	,	PUNCT	,	_	_	_	_	_
26	and	and	CCONJ	CC	_	_	_	_	_
27	STAT5	STAT5	NOUN	NN	Number=Sing	_	_	_	_
28	proteins	protein	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
29	;	;	PUNCT	,	_	_	_	_	_
30	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
31	2	2	X	LS	_	_	_	_	SpaceAfter=No
32	)	)	PUNCT	-RRB-	_	_	_	_	_
33	malignant	malignant	ADJ	JJ	Degree=Pos	_	_	_	_
34	transformation	transformation	NOUN	NN	Number=Sing	_	_	_	_
35	in	in	ADP	IN	_	_	_	_	_
36	at	at	ADV	RB	_	_	_	_	_
37	least	least	ADV	RBS	Degree=Sup	_	_	_	_
38	some	some	DET	DT	_	_	_	_	_
39	cases	case	NOUN	NNS	Number=Plur	_	_	_	_
40	of	of	ADP	IN	_	_	_	_	_
41	ATLL	ATLL	NOUN	NN	Number=Sing	_	_	_	_
42	does	do	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
43	not	not	PART	RB	_	_	_	_	_
44	require	require	VERB	VB	VerbForm=Inf	_	_	_	_
45	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
46	constitutive	constitutive	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
47	,	,	PUNCT	,	_	_	_	_	_
48	but	but	CCONJ	CC	_	_	_	_	_
49	may	may	AUX	MD	VerbForm=Fin	_	_	_	_
50	require	require	VERB	VB	VerbForm=Inf	_	_	_	_
51	IL	Il	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
52	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
53	2	2	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
54	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
55	induced	induce	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	SpaceAfter=No
56	,	,	PUNCT	,	_	_	_	_	_
57	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
58	of	of	ADP	IN	_	_	_	_	_
59	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
60	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
61	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
62	2R	2R	PROPN	NNP	Number=Sing	_	_	_	_
63	Jak/	Jak/	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
64	STAT	Stat	PROPN	NNP	Number=Sing	_	_	_	_
65	pathway	pathway	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
66	;	;	PUNCT	,	_	_	_	_	_
67	and	and	CCONJ	CC	_	_	_	_	_
68	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
69	3	3	X	LS	_	_	_	_	SpaceAfter=No
70	)	)	PUNCT	-RRB-	_	_	_	_	_
71	there	there	PRON	EX	_	_	_	_	_
72	are	be	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
73	major	major	ADJ	JJ	Degree=Pos	_	_	_	_
74	differences	difference	NOUN	NNS	Number=Plur	_	_	_	_
75	in	in	ADP	IN	_	_	_	_	_
76	T-	t-	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
77	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
78	immortalization	immortalization	NOUN	NN	Number=Sing	_	_	_	_
79	mechanism	mechanism	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
80	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
81	s	s	X	AFX	_	_	_	_	SpaceAfter=No
82	)	)	PUNCT	-RRB-	_	_	_	_	_
83	which	which	PRON	WDT	PronType=Rel	_	_	_	_
84	appear	appear	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
85	to	to	PART	TO	_	_	_	_	_
86	involve	involve	VERB	VB	VerbForm=Inf	_	_	_	_
87	SHP	sHp	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
88	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
89	1	1	NUM	CD	NumType=Card	_	_	_	_
90	and	and	CCONJ	CC	_	_	_	_	_
91	target	target	NOUN	NN	Number=Sing	_	_	_	_
92	molecules	molecule	NOUN	NNS	Number=Plur	_	_	_	_
93	for	for	ADP	IN	_	_	_	_	_
94	rapamycin	rapamycin	NOUN	NN	Number=Sing	_	_	_	_
95	and	and	CCONJ	CC	_	_	_	_	_
96	RAD	Rad	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
97	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 1723
# text = Document 00300311 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	00300311	00300311	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 1724
# text = Glucocorticoid-induced cell death requires autoinduction of glucocorticoid receptor expression in human leukemic T cells.
1	Glucocorticoid	Glucocorticoid	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
2	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
3	induced	induce	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
4	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
5	death	death	NOUN	NN	Number=Sing	_	_	_	_
6	requires	require	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
7	autoinduction	autoinduction	NOUN	NN	Number=Sing	_	_	_	_
8	of	of	ADP	IN	_	_	_	_	_
9	glucocorticoid	glucocorticoid	ADJ	JJ	Degree=Pos	_	_	_	_
10	receptor	receptor	NOUN	NN	Number=Sing	_	_	_	_
11	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
12	in	in	ADP	IN	_	_	_	_	_
13	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
14	leukemic	leukemic	ADJ	JJ	Degree=Pos	_	_	_	_
15	T	t	PROPN	NNP	Number=Sing	_	_	_	_
16	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
17	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 1725
# text = In contrast to the negative autoregulation of glucocorticoid receptor (GR) expression seen in most cells and tissues, GR expression is positively autoregulated in human leukemic T cells and in other cells sensitive to glucocorticoid-induced cell death.
1	In	in	ADP	IN	_	_	_	_	_
2	contrast	contrast	NOUN	NN	Number=Sing	_	_	_	_
3	to	to	ADP	IN	_	_	_	_	_
4	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
5	negative	negative	ADJ	JJ	Degree=Pos	_	_	_	_
6	autoregulation	autoregulation	NOUN	NN	Number=Sing	_	_	_	_
7	of	of	ADP	IN	_	_	_	_	_
8	glucocorticoid	glucocorticoid	ADJ	JJ	Degree=Pos	_	_	_	_
9	receptor	receptor	NOUN	NN	Number=Sing	_	_	_	_
10	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
11	GR	GR	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
12	)	)	PUNCT	-RRB-	_	_	_	_	_
13	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
14	seen	see	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
15	in	in	ADP	IN	_	_	_	_	_
16	most	most	ADJ	JJS	Degree=Sup	_	_	_	_
17	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
18	and	and	CCONJ	CC	_	_	_	_	_
19	tissues	tissue	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
20	,	,	PUNCT	,	_	_	_	_	_
21	GR	GR	PROPN	NNP	Number=Sing	_	_	_	_
22	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
23	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
24	positively	positively	ADV	RB	_	_	_	_	_
25	autoregulated	autoregulate	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
26	in	in	ADP	IN	_	_	_	_	_
27	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
28	leukemic	leukemic	ADJ	JJ	Degree=Pos	_	_	_	_
29	T	t	PROPN	NNP	Number=Sing	_	_	_	_
30	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
31	and	and	CCONJ	CC	_	_	_	_	_
32	in	in	ADP	IN	_	_	_	_	_
33	other	other	ADJ	JJ	Degree=Pos	_	_	_	_
34	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
35	sensitive	sensitive	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
36	to	to	PART	TO	_	_	_	_	_
37	glucocorticoid	glucocorticoid	VERB	VB	VerbForm=Inf	_	_	_	SpaceAfter=No
38	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
39	induced	induce	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
40	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
41	death	death	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
42	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1726
# text = To determine whether positive autoregulation is a necessary component of glucocorticoid-induced cell death, a wild-type GR gene under the control of a tetracycline-regulated promoter was stably transfected into glucocorticoid-resistant cells lacking endogenous functional receptor.
1	To	to	PART	TO	_	_	_	_	_
2	determine	determine	VERB	VB	VerbForm=Inf	_	_	_	_
3	whether	whether	SCONJ	IN	_	_	_	_	_
4	positive	positive	ADJ	JJ	Degree=Pos	_	_	_	_
5	autoregulation	autoregulation	NOUN	NN	Number=Sing	_	_	_	_
6	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
7	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
8	necessary	necessary	ADJ	JJ	Degree=Pos	_	_	_	_
9	component	component	NOUN	NN	Number=Sing	_	_	_	_
10	of	of	ADP	IN	_	_	_	_	_
11	glucocorticoid	glucocorticoid	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
12	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
13	induced	induce	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
14	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
15	death	death	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
16	,	,	PUNCT	,	_	_	_	_	_
17	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
18	wild	wild	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
19	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
20	type	type	NOUN	NN	Number=Sing	_	_	_	_
21	GR	Gr	NOUN	NN	Number=Sing	_	_	_	_
22	gene	gene	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
23	under	under	ADP	IN	_	_	_	_	_
24	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
25	control	control	NOUN	NN	Number=Sing	_	_	_	_
26	of	of	ADP	IN	_	_	_	_	_
27	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
28	tetracycline	tetracycline	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
29	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
30	regulated	regulate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
31	promoter	promoter	NOUN	NN	Number=Sing	_	_	_	_
32	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
33	stably	stably	ADV	RB	_	_	_	_	_
34	transfected	transfect	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
35	into	into	ADP	IN	_	_	_	_	_
36	glucocorticoid	glucocorticoid	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
37	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
38	resistant	resistant	NOUN	NN	Number=Sing	_	_	_	_
39	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
40	lacking	lack	VERB	VBG	VerbForm=Ger	_	_	_	_
41	endogenous	endogenous	ADJ	JJ	Degree=Pos	_	_	_	_
42	functional	functional	ADJ	JJ	Degree=Pos	_	_	_	_
43	receptor	receptor	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
44	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1727
# text = Transfectants grown in the presence of tetracycline contained about 15,000 receptors/cell, a value approximately equal to basal level GR expression in glucocorticoid-sensitive 6TG1.1 cells before steroid treatment.
1	Transfectants	Transfectant	NOUN	NNS	Number=Plur	_	_	_	_
2	grown	grow	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
3	in	in	ADP	IN	_	_	_	_	_
4	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
5	presence	presence	NOUN	NN	Number=Sing	_	_	_	_
6	of	of	ADP	IN	_	_	_	_	_
7	tetracycline	tetracycline	NOUN	NN	Number=Sing	_	_	_	_
8	contained	contain	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
9	about	about	ADV	RB	_	_	_	_	_
10	15,000	15,000	NUM	CD	NumType=Card	_	_	_	_
11	receptors	receptor	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
12	/	/	PUNCT	,	_	_	_	_	SpaceAfter=No
13	cell	cell	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
14	,	,	PUNCT	,	_	_	_	_	_
15	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
16	value	value	NOUN	NN	Number=Sing	_	_	_	_
17	approximately	approximately	ADV	RB	_	_	_	_	_
18	equal	equal	ADJ	JJ	Degree=Pos	_	_	_	_
19	to	to	ADP	IN	_	_	_	_	_
20	basal	basal	ADJ	JJ	Degree=Pos	_	_	_	_
21	level	level	NOUN	NN	Number=Sing	_	_	_	_
22	GR	Gr	NOUN	NN	Number=Sing	_	_	_	_
23	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
24	in	in	ADP	IN	_	_	_	_	_
25	glucocorticoid	glucocorticoid	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
26	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
27	sensitive	sensitive	ADJ	JJ	Degree=Pos	_	_	_	_
28	6TG1.1	6tg1.1	NUM	CD	NumType=Card	_	_	_	_
29	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
30	before	before	ADP	IN	_	_	_	_	_
31	steroid	steroid	ADJ	JJ	Degree=Pos	_	_	_	_
32	treatment	treatment	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
33	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1728
# text = Under these conditions, dexamethasone had a minimal effect on cell growth, elicited little internucleosomal DNA fragmentation, and induced no cell cycle perturbation.
1	Under	under	ADP	IN	_	_	_	_	_
2	these	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
3	conditions	condition	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	,	,	PUNCT	,	_	_	_	_	_
5	dexamethasone	dexamethasone	PRON	NN	Number=Sing	_	_	_	_
6	had	have	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
7	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
8	minimal	minimal	ADJ	JJ	Degree=Pos	_	_	_	_
9	effect	effect	NOUN	NN	Number=Sing	_	_	_	_
10	on	on	ADP	IN	_	_	_	_	_
11	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
12	growth	growth	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
13	,	,	PUNCT	,	_	_	_	_	_
14	elicited	elicit	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
15	little	little	ADJ	JJ	Degree=Pos	_	_	_	_
16	internucleosomal	internucleosomal	ADJ	JJ	Degree=Pos	_	_	_	_
17	DNA	dna	NOUN	NN	Number=Sing	_	_	_	_
18	fragmentation	fragmentation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
19	,	,	PUNCT	,	_	_	_	_	_
20	and	and	CCONJ	CC	_	_	_	_	_
21	induced	induce	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
22	no	no	DET	DT	_	_	_	_	_
23	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
24	cycle	cycle	NOUN	NN	Number=Sing	_	_	_	_
25	perturbation	perturbation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
26	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1729
# text = In the absence of tetracycline, GR mRNA and protein expression increased 2-3-fold, and cells expressed 48,000 receptors, a level nearly equivalent to that present in 6TG1.1 cells after 18 h of autoinduction.
1	In	in	ADP	IN	_	_	_	_	_
2	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
3	absence	absence	NOUN	NN	Number=Sing	_	_	_	_
4	of	of	ADP	IN	_	_	_	_	_
5	tetracycline	tetracycline	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
6	,	,	PUNCT	,	_	_	_	_	_
7	GR	GR	PROPN	NNP	Number=Sing	_	_	_	_
8	mRNA	mRNA	PROPN	NNP	Number=Sing	_	_	_	_
9	and	and	CCONJ	CC	_	_	_	_	_
10	protein	protein	VERB	VB	VerbForm=Inf	_	_	_	_
11	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
12	increased	increase	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
13	2	2	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
14	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
15	3	3	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
16	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
17	fold	fold	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
18	,	,	PUNCT	,	_	_	_	_	_
19	and	and	CCONJ	CC	_	_	_	_	_
20	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
21	expressed	express	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
22	48,000	48,000	NUM	CD	NumType=Card	_	_	_	_
23	receptors	receptor	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
24	,	,	PUNCT	,	_	_	_	_	_
25	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
26	level	level	NOUN	NN	Number=Sing	_	_	_	_
27	nearly	nearly	ADV	RB	_	_	_	_	_
28	equivalent	equivalent	ADJ	JJ	Degree=Pos	_	_	_	_
29	to	to	ADP	IN	_	_	_	_	_
30	that	that	PRON	DT	Number=Sing|PronType=Dem	_	_	_	_
31	present	present	ADJ	JJ	Degree=Pos	_	_	_	_
32	in	in	ADP	IN	_	_	_	_	_
33	6TG1.1	6TG1.1	NUM	CD	NumType=Card	_	_	_	_
34	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
35	after	after	ADP	IN	_	_	_	_	_
36	18	18	NUM	CD	NumType=Card	_	_	_	_
37	h	h	NOUN	NN	Number=Sing	_	_	_	_
38	of	of	ADP	IN	_	_	_	_	_
39	autoinduction	autoinduction	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
40	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1730
# text = Under these conditions, dexamethasone markedly inhibited cell growth, caused G1 arrest, and induced significant internucleosomal DNA fragmentation.
1	Under	under	ADP	IN	_	_	_	_	_
2	these	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
3	conditions	condition	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	,	,	PUNCT	,	_	_	_	_	_
5	dexamethasone	dexamethasone	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
6	markedly	markedly	ADV	RB	_	_	_	_	_
7	inhibited	inhibit	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
8	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
9	growth	growth	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
10	,	,	PUNCT	,	_	_	_	_	_
11	caused	cause	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
12	G1	G1	NUM	CD	NumType=Card	_	_	_	_
13	arrest	arrest	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
14	,	,	PUNCT	,	_	_	_	_	_
15	and	and	CCONJ	CC	_	_	_	_	_
16	induced	induce	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
17	significant	significant	ADJ	JJ	Degree=Pos	_	_	_	_
18	internucleosomal	internucleosomal	ADJ	JJ	Degree=Pos	_	_	_	_
19	DNA	dna	NOUN	NN	Number=Sing	_	_	_	_
20	fragmentation	fragmentation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
21	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1731
# text = These studies therefore suggest that basal level GR expression is inadequate to mediate glucocorticoid-induced apoptosis in glucocorticoid-sensitive T cells and that positive autoregulation is a necessary component of this process.
1	These	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
2	studies	study	NOUN	NNS	Number=Plur	_	_	_	_
3	therefore	therefore	ADV	RB	_	_	_	_	_
4	suggest	suggest	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
5	that	that	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
6	basal	basal	ADJ	JJ	Degree=Pos	_	_	_	_
7	level	level	NOUN	NN	Number=Sing	_	_	_	_
8	GR	Gr	NOUN	NN	Number=Sing	_	_	_	_
9	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
10	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
11	inadequate	inadequate	ADJ	JJ	Degree=Pos	_	_	_	_
12	to	to	PART	TO	_	_	_	_	_
13	mediate	mediate	VERB	VB	VerbForm=Inf	_	_	_	_
14	glucocorticoid	glucocorticoid	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
15	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
16	induced	induce	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
17	apoptosis	apoptosis	NOUN	NN	Number=Sing	_	_	_	_
18	in	in	ADP	IN	_	_	_	_	_
19	glucocorticoid	glucocorticoid	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
20	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
21	sensitive	sensitive	ADJ	JJ	Degree=Pos	_	_	_	_
22	T	t	PROPN	NNP	Number=Sing	_	_	_	_
23	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
24	and	and	CCONJ	CC	_	_	_	_	_
25	that	that	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
26	positive	positive	ADJ	JJ	Degree=Pos	_	_	_	_
27	autoregulation	autoregulation	NOUN	NN	Number=Sing	_	_	_	_
28	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
29	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
30	necessary	necessary	ADJ	JJ	Degree=Pos	_	_	_	_
31	component	component	NOUN	NN	Number=Sing	_	_	_	_
32	of	of	ADP	IN	_	_	_	_	_
33	this	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
34	process	process	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
35	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 1732
# text = Document 00300312 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	00300312	00300312	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 1733
# text = Modulation of normal erythroid differentiation by the endogenous thyroid hormone and retinoic acid receptors:
1	Modulation	Modulation	NOUN	NN	Number=Sing	_	_	_	_
2	of	of	ADP	IN	_	_	_	_	_
3	normal	normal	ADJ	JJ	Degree=Pos	_	_	_	_
4	erythroid	erythroid	ADJ	JJ	Degree=Pos	_	_	_	_
5	differentiation	differentiation	NOUN	NN	Number=Sing	_	_	_	_
6	by	by	ADP	IN	_	_	_	_	_
7	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
8	endogenous	endogenous	ADJ	JJ	Degree=Pos	_	_	_	_
9	thyroid	thyroid	NOUN	NN	Number=Sing	_	_	_	_
10	hormone	hormone	NOUN	NN	Number=Sing	_	_	_	_
11	and	and	CCONJ	CC	_	_	_	_	_
12	retinoic	retinoic	ADJ	JJ	Degree=Pos	_	_	_	_
13	acid	acid	ADJ	JJ	Degree=Pos	_	_	_	_
14	receptors	receptor	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
15	:	:	PUNCT	:	_	_	_	_	_

# sent_id = 1734
# text = a possible target for v-erbA oncogene action.
1	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
2	possible	possible	ADJ	JJ	Degree=Pos	_	_	_	_
3	target	target	NOUN	NN	Number=Sing	_	_	_	_
4	for	for	ADP	IN	_	_	_	_	_
5	v-	v-	SYM	NFP	_	_	_	_	SpaceAfter=No
6	erbA	erbA	SYM	SYM	_	_	_	_	_
7	oncogene	oncogene	ADJ	JJ	Degree=Pos	_	_	_	_
8	action	action	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
9	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 1735
# text = The v-erbA oncogene, a mutated version of the thyroid hormone receptor alpha (c-erbA/TR-alpha), inhibits erythroid differentiation and constitutively represses transcription of certain erythrocyte genes, suggesting a normal function of the proto-oncogene c-erbA in erythropoiesis.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	v-	v-	SYM	NFP	_	_	_	_	SpaceAfter=No
3	erbA	erba	PROPN	NNP	Number=Sing	_	_	_	_
4	oncogene	oncogene	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
5	,	,	PUNCT	,	_	_	_	_	_
6	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
7	mutated	mutate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
8	version	version	NOUN	NN	Number=Sing	_	_	_	_
9	of	of	ADP	IN	_	_	_	_	_
10	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
11	thyroid	thyroid	NOUN	NN	Number=Sing	_	_	_	_
12	hormone	hormone	NOUN	NN	Number=Sing	_	_	_	_
13	receptor	receptor	NOUN	NN	Number=Sing	_	_	_	_
14	alpha	alpha	NOUN	NN	Number=Sing	_	_	_	_
15	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
16	c-	c-	PUNCT	,	_	_	_	_	SpaceAfter=No
17	erbA/TR-alpha	erbA/TR-alpha	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
18	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
19	,	,	PUNCT	,	_	_	_	_	_
20	inhibits	inhibits	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
21	erythroid	erythroid	ADJ	JJ	Degree=Pos	_	_	_	_
22	differentiation	differentiation	NOUN	NN	Number=Sing	_	_	_	_
23	and	and	CCONJ	CC	_	_	_	_	_
24	constitutively	constitutively	ADV	RB	_	_	_	_	_
25	represses	repress	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
26	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
27	of	of	ADP	IN	_	_	_	_	_
28	certain	certain	ADJ	JJ	Degree=Pos	_	_	_	_
29	erythrocyte	erythrocyte	NOUN	NN	Number=Sing	_	_	_	_
30	genes	gene	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
31	,	,	PUNCT	,	_	_	_	_	_
32	suggesting	suggest	VERB	VBG	VerbForm=Ger	_	_	_	_
33	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
34	normal	normal	ADJ	JJ	Degree=Pos	_	_	_	_
35	function	function	NOUN	NN	Number=Sing	_	_	_	_
36	of	of	ADP	IN	_	_	_	_	_
37	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
38	proto	proto	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
39	-oncogene	-oncogene	NOUN	NN	Number=Sing	_	_	_	_
40	c-	c-	PUNCT	:	_	_	_	_	SpaceAfter=No
41	erbA	erbA	PROPN	NNP	Number=Sing	_	_	_	_
42	in	in	ADP	IN	_	_	_	_	_
43	erythropoiesis	erythropoiesis	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
44	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1736
# text = Here we demonstrate that the endogenous thyroid hormone receptor alpha (c-erbA/TR-alpha) and the closely related retinoic acid receptor alpha (RAR-alpha) play a role in the regulation of normal erythroid differentiation.
1	Here	here	ADV	RB	PronType=Dem	_	_	_	_
2	we	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
3	demonstrate	demonstrate	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
4	that	that	SCONJ	IN	_	_	_	_	_
5	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
6	endogenous	endogenous	ADJ	JJ	Degree=Pos	_	_	_	_
7	thyroid	thyroid	NOUN	NN	Number=Sing	_	_	_	_
8	hormone	hormone	NOUN	NN	Number=Sing	_	_	_	_
9	receptor	receptor	NOUN	NN	Number=Sing	_	_	_	_
10	alpha	alpha	NOUN	NN	Number=Sing	_	_	_	_
11	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
12	c-	c-	X	GW	_	_	_	_	SpaceAfter=No
13	erbA/TR-	erbA/TR-	X	GW	_	_	_	_	SpaceAfter=No
14	alpha	alpha	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
15	)	)	PUNCT	-RRB-	_	_	_	_	_
16	and	and	CCONJ	CC	_	_	_	_	_
17	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
18	closely	closely	ADV	RB	_	_	_	_	_
19	related	related	ADJ	JJ	Degree=Pos	_	_	_	_
20	retinoic	retinoic	X	GW	_	_	_	_	_
21	acid	acid	X	GW	_	_	_	_	_
22	receptor	receptor	X	GW	_	_	_	_	_
23	alpha	alpha	X	GW	_	_	_	_	_
24	(	(	X	GW	_	_	_	_	SpaceAfter=No
25	RAR	Rar	X	GW	_	_	_	_	SpaceAfter=No
26	-	-	X	GW	_	_	_	_	SpaceAfter=No
27	alpha	alpha	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
28	)	)	PUNCT	-RRB-	_	_	_	_	_
29	play	play	VERB	VB	VerbForm=Inf	_	_	_	_
30	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
31	role	role	NOUN	NN	Number=Sing	_	_	_	_
32	in	in	ADP	IN	_	_	_	_	_
33	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
34	regulation	regulation	NOUN	NN	Number=Sing	_	_	_	_
35	of	of	ADP	IN	_	_	_	_	_
36	normal	normal	ADJ	JJ	Degree=Pos	_	_	_	_
37	erythroid	erythroid	ADJ	JJ	Degree=Pos	_	_	_	_
38	differentiation	differentiation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
39	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1737
# text = Retinoic acid (RA) distinctly modulated the erythroid differentiation program of normal erythroid progenitors and erythroblasts reversibly transformed by a conditional tyrosine kinase oncogene.
1	Retinoic	Retinoic	ADJ	JJ	Degree=Pos	_	_	_	_
2	acid	acid	NOUN	NN	Number=Sing	_	_	_	_
3	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
4	RA	RA	X	AFX	_	_	_	_	SpaceAfter=No
5	)	)	PUNCT	-RRB-	_	_	_	_	_
6	distinctly	distinctly	ADV	RB	_	_	_	_	_
7	modulated	modulate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
8	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
9	erythroid	erythroid	ADJ	JJ	Degree=Pos	_	_	_	_
10	differentiation	differentiation	NOUN	NN	Number=Sing	_	_	_	_
11	program	program	NOUN	NN	Number=Sing	_	_	_	_
12	of	of	ADP	IN	_	_	_	_	_
13	normal	normal	ADJ	JJ	Degree=Pos	_	_	_	_
14	erythroid	erythroid	ADJ	JJ	Degree=Pos	_	_	_	_
15	progenitors	progenitor	NOUN	NNS	Number=Plur	_	_	_	_
16	and	and	CCONJ	CC	_	_	_	_	_
17	erythroblasts	erythroblast	NOUN	NNS	Number=Plur	_	_	_	_
18	reversibly	reversibly	ADV	RB	_	_	_	_	_
19	transformed	transform	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
20	by	by	ADP	IN	_	_	_	_	_
21	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
22	conditional	conditional	ADJ	JJ	Degree=Pos	_	_	_	_
23	tyrosine	tyrosine	NOUN	NN	Number=Sing	_	_	_	_
24	kinase	kinase	NOUN	NN	Number=Sing	_	_	_	_
25	oncogene	oncogene	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
26	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1738
# text = When added pulsewise to immature cells, differentiation was accelerated while more mature cells underwent premature cell death.
1	When	when	ADV	WRB	PronType=Int	_	_	_	_
2	added	add	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
3	pulsewise	pulsewise	NOUN	NN	Number=Sing	_	_	_	_
4	to	to	ADP	IN	_	_	_	_	_
5	immature	immature	ADJ	JJ	Degree=Pos	_	_	_	_
6	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
7	,	,	PUNCT	,	_	_	_	_	_
8	differentiation	differentiation	NOUN	NN	Number=Sing	_	_	_	_
9	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
10	accelerated	accelerated	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
11	while	while	SCONJ	IN	_	_	_	_	_
12	more	more	ADV	RBR	_	_	_	_	_
13	mature	mature	ADJ	JJ	Degree=Pos	_	_	_	_
14	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
15	underwent	underwent	ADJ	JJ	Degree=Pos	_	_	_	_
16	premature	premature	ADJ	JJ	Degree=Pos	_	_	_	_
17	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
18	death	death	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
19	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1739
# text = Thyroid hormone (T3) alone caused similar but weaker effects.
1	Thyroid	thyroid	ADJ	JJ	Degree=Pos	_	_	_	_
2	hormone	hormone	NOUN	NN	Number=Sing	_	_	_	_
3	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
4	T3	T3	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
5	)	)	PUNCT	-RRB-	_	_	_	_	_
6	alone	alone	PRON	NN	Number=Sing	_	_	_	_
7	caused	cause	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
8	similar	similar	ADJ	JJ	Degree=Pos	_	_	_	_
9	but	but	CCONJ	CC	_	_	_	_	_
10	weaker	weaker	ADJ	JJ	Degree=Pos	_	_	_	_
11	effects	effect	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
12	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1740
# text = Interestingly, T3 strongly enhanced the action of RA, suggesting cooperative action of the two receptors in modulating erythroid differentiation.
1	Interestingly	Interestingly	ADV	RB	_	_	_	_	SpaceAfter=No
2	,	,	PUNCT	,	_	_	_	_	_
3	T3	T3	NUM	CD	NumType=Card	_	_	_	_
4	strongly	strongly	ADV	RB	_	_	_	_	_
5	enhanced	enhance	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
6	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
7	action	action	NOUN	NN	Number=Sing	_	_	_	_
8	of	of	ADP	IN	_	_	_	_	_
9	RA	RA	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
10	,	,	PUNCT	,	_	_	_	_	_
11	suggesting	suggest	VERB	VBG	VerbForm=Ger	_	_	_	_
12	cooperative	cooperative	ADJ	JJ	Degree=Pos	_	_	_	_
13	action	action	NOUN	NN	Number=Sing	_	_	_	_
14	of	of	ADP	IN	_	_	_	_	_
15	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
16	two	two	NUM	CD	NumType=Card	_	_	_	_
17	receptors	receptor	NOUN	NNS	Number=Plur	_	_	_	_
18	in	in	SCONJ	IN	_	_	_	_	_
19	modulating	modulat	VERB	VBG	VerbForm=Ger	_	_	_	_
20	erythroid	erythroid	ADJ	JJ	Degree=Pos	_	_	_	_
21	differentiation	differentiation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
22	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1741
# text = Expression of the human RAR-alpha in receptor-negative erythroblasts conferred RA-induced regulation of differentiation to the otherwise unresponsive cells, thus showing that the RAR-alpha is essential for the RA effect.
1	Expression	expression	NOUN	NN	Number=Sing	_	_	_	_
2	of	of	ADP	IN	_	_	_	_	_
3	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
4	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
5	RAR	Rar	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
6	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
7	alpha	alpha	NOUN	NN	Number=Sing	_	_	_	_
8	in	in	ADP	IN	_	_	_	_	_
9	receptor	receptor	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
10	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
11	negative	negative	ADJ	JJ	Degree=Pos	_	_	_	_
12	erythroblasts	erythroblast	NOUN	NNS	Number=Plur	_	_	_	_
13	conferred	confer	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
14	RA	RA	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
15	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
16	induced	induce	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
17	regulation	regulation	NOUN	NN	Number=Sing	_	_	_	_
18	of	of	ADP	IN	_	_	_	_	_
19	differentiation	differentiation	NOUN	NN	Number=Sing	_	_	_	_
20	to	to	ADP	IN	_	_	_	_	_
21	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
22	otherwise	otherwise	ADJ	JJ	Degree=Pos	_	_	_	_
23	unresponsive	unresponsive	ADJ	JJ	Degree=Pos	_	_	_	_
24	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
25	,	,	PUNCT	,	_	_	_	_	_
26	thus	thus	ADV	RB	_	_	_	_	_
27	showing	show	VERB	VBG	VerbForm=Ger	_	_	_	_
28	that	that	SCONJ	IN	_	_	_	_	_
29	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
30	RAR	Rar	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
31	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
32	alpha	alpha	NOUN	NN	Number=Sing	_	_	_	_
33	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
34	essential	essential	ADJ	JJ	Degree=Pos	_	_	_	_
35	for	for	ADP	IN	_	_	_	_	_
36	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
37	RA	RA	PROPN	NNP	Number=Sing	_	_	_	_
38	effect	effect	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
39	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1742
# text = Likewise, enhanced expression of exogenous c-erbA/TR-alpha in erythroblasts rendered them susceptible to modulation of differentiation by T3, suggesting a similar function of both receptors.
1	Likewise	likewise	ADV	RB	_	_	_	_	SpaceAfter=No
2	,	,	PUNCT	,	_	_	_	_	_
3	enhanced	enhance	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
4	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
5	of	of	ADP	IN	_	_	_	_	_
6	exogenous	exogenous	ADJ	JJ	Degree=Pos	_	_	_	_
7	c-	c-	PUNCT	:	_	_	_	_	SpaceAfter=No
8	erbA/TR-alpha	erbA/TR-alpha	NOUN	NN	Number=Sing	_	_	_	_
9	in	in	ADP	IN	_	_	_	_	_
10	erythroblasts	erythroblast	NOUN	NNS	Number=Plur	_	_	_	_
11	rendered	render	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
12	them	they	PRON	PRP	Case=Acc|Number=Plur|Person=3|PronType=Prs	_	_	_	_
13	susceptible	susceptible	ADJ	JJ	Degree=Pos	_	_	_	_
14	to	to	ADP	IN	_	_	_	_	_
15	modulation	modulation	NOUN	NN	Number=Sing	_	_	_	_
16	of	of	ADP	IN	_	_	_	_	_
17	differentiation	differentiation	NOUN	NN	Number=Sing	_	_	_	_
18	by	by	ADP	IN	_	_	_	_	_
19	T3	T3	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
20	,	,	PUNCT	,	_	_	_	_	_
21	suggesting	suggest	VERB	VBG	VerbForm=Ger	_	_	_	_
22	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
23	similar	similar	ADJ	JJ	Degree=Pos	_	_	_	_
24	function	function	NOUN	NN	Number=Sing	_	_	_	_
25	of	of	ADP	IN	_	_	_	_	_
26	both	both	DET	DT	_	_	_	_	_
27	receptors	receptor	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
28	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 1743
# text = Document 00300319 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	00300319	00300319	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 1744
# text = The internal methionine codons of human T-cell leukemia virus type II rex gene are not required for p24rex production or virus replication and transformation.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	internal	internal	ADJ	JJ	Degree=Pos	_	_	_	_
3	methionine	methionine	NOUN	NN	Number=Sing	_	_	_	_
4	codons	codon	NOUN	NNS	Number=Plur	_	_	_	_
5	of	of	ADP	IN	_	_	_	_	_
6	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
7	T-	t-	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
8	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
9	leukemia	leukemia	NOUN	NN	Number=Sing	_	_	_	_
10	virus	virus	NOUN	NN	Number=Sing	_	_	_	_
11	type	type	NOUN	NN	Number=Sing	_	_	_	_
12	II	ii	NUM	CD	NumType=Card	_	_	_	_
13	rex	rex	NOUN	NN	Number=Sing	_	_	_	_
14	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
15	are	be	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
16	not	not	PART	RB	_	_	_	_	_
17	required	require	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
18	for	for	ADP	IN	_	_	_	_	_
19	p24rex	p24rex	NOUN	NN	Number=Sing	_	_	_	_
20	production	production	NOUN	NN	Number=Sing	_	_	_	_
21	or	or	CCONJ	CC	_	_	_	_	_
22	virus	virus	NOUN	NN	Number=Sing	_	_	_	_
23	replication	replication	NOUN	NN	Number=Sing	_	_	_	_
24	and	and	CCONJ	CC	_	_	_	_	_
25	transformation	transformation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
26	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 1745
# text = Human T-cell leukemia virus types I (HTLV-I) and II (HTLV-II) have two nonstructural trans-acting regulatory genes, tax and rex, located in the 3' region of the viral genome.
1	Human	human	ADJ	JJ	Degree=Pos	_	_	_	_
2	T-	t-	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
3	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
4	leukemia	leukemia	NOUN	NN	Number=Sing	_	_	_	_
5	virus	virus	NOUN	NN	Number=Sing	_	_	_	_
6	types	type	NOUN	NNS	Number=Plur	_	_	_	_
7	I	I	PRON	PRP	Case=Nom|Number=Sing|Person=1|PronType=Prs	_	_	_	_
8	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
9	HTLV	HTLV	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
10	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
11	I	I	PRON	PRP	Case=Nom|Number=Sing|Person=1|PronType=Prs	_	_	_	SpaceAfter=No
12	)	)	PUNCT	-RRB-	_	_	_	_	_
13	and	and	CCONJ	CC	_	_	_	_	_
14	II	II	PROPN	NNP	Number=Sing	_	_	_	_
15	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
16	HTLV	HTLV	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
17	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
18	II	ii	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
19	)	)	PUNCT	-RRB-	_	_	_	_	_
20	have	have	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
21	two	two	NUM	CD	NumType=Card	_	_	_	_
22	nonstructural	nonstructural	ADJ	JJ	Degree=Pos	_	_	_	_
23	trans	tran	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
24	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
25	acting	act	VERB	VBG	VerbForm=Ger	_	_	_	_
26	regulatory	regulatory	ADJ	JJ	Degree=Pos	_	_	_	_
27	genes	gene	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
28	,	,	PUNCT	,	_	_	_	_	_
29	tax	tax	NOUN	NN	Number=Sing	_	_	_	_
30	and	and	CCONJ	CC	_	_	_	_	_
31	rex	rex	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
32	,	,	PUNCT	,	_	_	_	_	_
33	located	locate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
34	in	in	ADP	IN	_	_	_	_	_
35	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
36	3	3	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
37	'	'	PUNCT	``	_	_	_	_	_
38	region	region	NOUN	NN	Number=Sing	_	_	_	_
39	of	of	ADP	IN	_	_	_	_	_
40	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
41	viral	viral	ADJ	JJ	Degree=Pos	_	_	_	_
42	genome	genome	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
43	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1746
# text = The tax gene product (HTLV-I p40tax and HTLV-II p37tax) is the transcriptional activator of the viral long terminal repeat.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	tax	tax	NOUN	NN	Number=Sing	_	_	_	_
3	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
4	product	product	NOUN	NN	Number=Sing	_	_	_	_
5	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
6	HTLV	Htlv	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
7	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
8	I	I	PRON	PRP	Case=Nom|Number=Sing|Person=1|PronType=Prs	_	_	_	_
9	p40	p40	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
10	tax	tax	NOUN	NN	Number=Sing	_	_	_	_
11	and	and	CCONJ	CC	_	_	_	_	_
12	HTLV	Htlv	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
13	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
14	II	ii	NUM	CD	NumType=Card	_	_	_	_
15	p37tax	p37tax	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
16	)	)	PUNCT	-RRB-	_	_	_	_	_
17	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
18	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
19	transcriptional	transcriptional	ADJ	JJ	Degree=Pos	_	_	_	_
20	activator	activator	NOUN	NN	Number=Sing	_	_	_	_
21	of	of	ADP	IN	_	_	_	_	_
22	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
23	viral	viral	ADJ	JJ	Degree=Pos	_	_	_	_
24	long	long	ADJ	JJ	Degree=Pos	_	_	_	_
25	terminal	terminal	NOUN	NN	Number=Sing	_	_	_	_
26	repeat	repeat	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	SpaceAfter=No
27	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1747
# text = The rex gene encodes two protein products, p27rex/p21rex and p26rex/p24rex in HTLV-I and HTLV-II, respectively.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	rex	rex	NOUN	NN	Number=Sing	_	_	_	_
3	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
4	encodes	encode	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
5	two	two	NUM	CD	NumType=Card	_	_	_	_
6	protein	protein	NOUN	NN	Number=Sing	_	_	_	_
7	products	product	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
8	,	,	PUNCT	,	_	_	_	_	_
9	p27rex/	p27rex/	SYM	NFP	_	_	_	_	SpaceAfter=No
10	p21rex	p21rex	NOUN	NN	Number=Sing	_	_	_	_
11	and	and	CCONJ	CC	_	_	_	_	_
12	p26rex/	p26rexith	ADP	IN	Abbr=Yes	_	_	_	SpaceAfter=No
13	p24rex	p24rex	NOUN	NN	Number=Sing	_	_	_	_
14	in	in	ADP	IN	_	_	_	_	_
15	HTLV	HTLV	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
16	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
17	I	I	PRON	PRP	Case=Nom|Number=Sing|Person=1|PronType=Prs	_	_	_	_
18	and	and	CCONJ	CC	_	_	_	_	_
19	HTLV	HTLV	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
20	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
21	II	ii	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
22	,	,	PUNCT	,	_	_	_	_	_
23	respectively	respectively	ADV	RB	_	_	_	_	SpaceAfter=No
24	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1748
# text = Rex acts posttranscriptionally to facilitate accumulation of full-length gag/pol and singly spliced env mRNA in the cytoplasm of HTLV-infected cells.
1	Rex	Rex	NOUN	NN	Number=Sing	_	_	_	_
2	acts	act	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
3	posttranscriptionally	posttranscriptionally	ADV	RB	_	_	_	_	_
4	to	to	PART	TO	_	_	_	_	_
5	facilitate	facilitate	VERB	VB	VerbForm=Inf	_	_	_	_
6	accumulation	accumulation	NOUN	NN	Number=Sing	_	_	_	_
7	of	of	ADP	IN	_	_	_	_	_
8	full	full	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
9	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
10	length	length	NOUN	NN	Number=Sing	_	_	_	_
11	gag	gag	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
12	/	/	PUNCT	,	_	_	_	_	SpaceAfter=No
13	pol	pol	NOUN	NN	Number=Sing	_	_	_	_
14	and	and	CCONJ	CC	_	_	_	_	_
15	singly	singly	ADV	RB	_	_	_	_	_
16	spliced	splice	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
17	env	env	NOUN	NN	Number=Sing	_	_	_	_
18	mRNA	mRNa	NOUN	NN	Number=Sing	_	_	_	_
19	in	in	ADP	IN	_	_	_	_	_
20	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
21	cytoplasm	cytoplasm	NOUN	NN	Number=Sing	_	_	_	_
22	of	of	ADP	IN	_	_	_	_	_
23	HTLV	HTLV	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
24	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
25	infected	infect	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
26	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
27	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1749
# text = Previous studies showed that the first ATG of the rex gene is critical for Rex production and function.
1	Previous	previous	ADJ	JJ	Degree=Pos	_	_	_	_
2	studies	study	NOUN	NNS	Number=Plur	_	_	_	_
3	showed	show	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
4	that	that	SCONJ	IN	_	_	_	_	_
5	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
6	first	first	ADJ	JJ	Degree=Pos|NumType=Ord	_	_	_	_
7	ATG	Atg	NOUN	NN	Number=Sing	_	_	_	_
8	of	of	ADP	IN	_	_	_	_	_
9	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
10	rex	rex	NOUN	NN	Number=Sing	_	_	_	_
11	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
12	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
13	critical	critical	ADJ	JJ	Degree=Pos	_	_	_	_
14	for	for	ADP	IN	_	_	_	_	_
15	Rex	Rex	NOUN	NN	Number=Sing	_	_	_	_
16	production	production	NOUN	NN	Number=Sing	_	_	_	_
17	and	and	CCONJ	CC	_	_	_	_	_
18	function	function	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
19	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1750
# text = The importance of the internal ATGs to Rex function is not known.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	importance	importance	NOUN	NN	Number=Sing	_	_	_	_
3	of	of	ADP	IN	_	_	_	_	_
4	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
5	internal	internal	ADJ	JJ	Degree=Pos	_	_	_	_
6	ATGs	ATGs	NOUN	NNS	Number=Plur	_	_	_	_
7	to	to	ADP	IN	_	_	_	_	_
8	Rex	Rex	NOUN	NN	Number=Sing	_	_	_	_
9	function	function	NOUN	NN	Number=Sing	_	_	_	_
10	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
11	not	not	PART	RB	_	_	_	_	_
12	known	known	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
13	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1751
# text = However, in vitro mutagenesis of the HTLV-I rex gene has provided indirect evidence which suggests that p21rex, and by analogy HTLV-II p24rex, results from initiation at an internal AUG of the tax/rex mRNA.
1	However	however	ADV	RB	_	_	_	_	SpaceAfter=No
2	,	,	PUNCT	,	_	_	_	_	_
3	in	in	ADP	IN	_	_	_	_	_
4	vitro	vitro	ADJ	JJ	Degree=Pos	_	_	_	_
5	mutagenesis	mutagenesis	NOUN	NN	Number=Sing	_	_	_	_
6	of	of	ADP	IN	_	_	_	_	_
7	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
8	HTLV	HTLV	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
9	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
10	I	I	PRON	PRP	Case=Nom|Number=Sing|Person=1|PronType=Prs	_	_	_	_
11	rex	rex	VERB	VB	VerbForm=Inf	_	_	_	_
12	gene	gene	PRON	NN	Number=Sing	_	_	_	_
13	has	have	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
14	provided	provide	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
15	indirect	indirect	ADJ	JJ	Degree=Pos	_	_	_	_
16	evidence	evidence	NOUN	NN	Number=Sing	_	_	_	_
17	which	which	PRON	WDT	PronType=Rel	_	_	_	_
18	suggests	suggest	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
19	that	that	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
20	p21rex	p21rex	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
21	,	,	PUNCT	,	_	_	_	_	_
22	and	and	CCONJ	CC	_	_	_	_	_
23	by	by	ADP	IN	_	_	_	_	_
24	analogy	analogy	NOUN	NN	Number=Sing	_	_	_	_
25	HTLV	Htlv	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
26	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
27	II	ii	NUM	CD	NumType=Card	_	_	_	_
28	p24rex	p24rex	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
29	,	,	PUNCT	,	_	_	_	_	_
30	results	result	NOUN	NNS	Number=Plur	_	_	_	_
31	from	from	ADP	IN	_	_	_	_	_
32	initiation	initiation	NOUN	NN	Number=Sing	_	_	_	_
33	at	at	ADP	IN	_	_	_	_	_
34	an	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
35	internal	internal	ADJ	JJ	Degree=Pos	_	_	_	_
36	AUG	Aug	NOUN	NN	Number=Sing	_	_	_	_
37	of	of	ADP	IN	_	_	_	_	_
38	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
39	tax	tax	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
40	/	/	PUNCT	,	_	_	_	_	SpaceAfter=No
41	rex	rex	NOUN	NN	Number=Sing	_	_	_	_
42	mRNA	mRNa	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
43	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1752
# text = By using an infectious molecular clone of HTLV-II, we investigated the importance of the internal ATGs of the rex gene on Rex protein production and function.
1	By	by	SCONJ	IN	_	_	_	_	_
2	using	use	VERB	VBG	VerbForm=Ger	_	_	_	_
3	an	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
4	infectious	infectious	ADJ	JJ	Degree=Pos	_	_	_	_
5	molecular	molecular	ADJ	JJ	Degree=Pos	_	_	_	_
6	clone	clone	NOUN	NN	Number=Sing	_	_	_	_
7	of	of	ADP	IN	_	_	_	_	_
8	HTLV	HTLV	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
9	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
10	II	II	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
11	,	,	PUNCT	,	_	_	_	_	_
12	we	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
13	investigated	investigate	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
14	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
15	importance	importance	NOUN	NN	Number=Sing	_	_	_	_
16	of	of	ADP	IN	_	_	_	_	_
17	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
18	internal	internal	ADJ	JJ	Degree=Pos	_	_	_	_
19	ATGs	ATGs	NOUN	NNS	Number=Plur	_	_	_	_
20	of	of	ADP	IN	_	_	_	_	_
21	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
22	rex	rex	NOUN	NN	Number=Sing	_	_	_	_
23	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
24	on	on	ADP	IN	_	_	_	_	_
25	Rex	Rex	NOUN	NN	Number=Sing	_	_	_	_
26	protein	protein	NOUN	NN	Number=Sing	_	_	_	_
27	production	production	NOUN	NN	Number=Sing	_	_	_	_
28	and	and	CCONJ	CC	_	_	_	_	_
29	function	function	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
30	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1753
# text = Our results indicate that p24rex of HTLV-II is not initiated at an internal AUG and that the internal methionine codons are not crucial to the function of the rex gene and, ultimately, the transforming properties of the virus.
1	Our	we	PRON	PRP$	Number=Plur|Person=1|Poss=Yes|PronType=Prs	_	_	_	_
2	results	result	NOUN	NNS	Number=Plur	_	_	_	_
3	indicate	indicate	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
4	that	that	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
5	p24rex	p24rex	NOUN	NN	Number=Sing	_	_	_	_
6	of	of	ADP	IN	_	_	_	_	_
7	HTLV	HTLV	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
8	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
9	II	II	PROPN	NNP	Number=Sing	_	_	_	_
10	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
11	not	not	PART	RB	_	_	_	_	_
12	initiated	initiate	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
13	at	at	ADP	IN	_	_	_	_	_
14	an	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
15	internal	internal	ADJ	JJ	Degree=Pos	_	_	_	_
16	AUG	Aug	NOUN	NN	Number=Sing	_	_	_	_
17	and	and	CCONJ	CC	_	_	_	_	_
18	that	that	SCONJ	IN	_	_	_	_	_
19	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
20	internal	internal	ADJ	JJ	Degree=Pos	_	_	_	_
21	methionine	methionine	NOUN	NN	Number=Sing	_	_	_	_
22	codons	codon	NOUN	NNS	Number=Plur	_	_	_	_
23	are	be	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
24	not	not	PART	RB	_	_	_	_	_
25	crucial	crucial	ADJ	JJ	Degree=Pos	_	_	_	_
26	to	to	ADP	IN	_	_	_	_	_
27	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
28	function	function	NOUN	NN	Number=Sing	_	_	_	_
29	of	of	ADP	IN	_	_	_	_	_
30	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
31	rex	rex	NOUN	NN	Number=Sing	_	_	_	_
32	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
33	and	and	CCONJ	CC	_	_	_	_	SpaceAfter=No
34	,	,	PUNCT	,	_	_	_	_	_
35	ultimately	ultimately	ADV	RB	_	_	_	_	SpaceAfter=No
36	,	,	PUNCT	,	_	_	_	_	_
37	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
38	transforming	transforming	VERB	VBG	VerbForm=Ger	_	_	_	_
39	properties	property	NOUN	NNS	Number=Plur	_	_	_	_
40	of	of	ADP	IN	_	_	_	_	_
41	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
42	virus	virus	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
43	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 1754
# text = Document 00300320 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	00300320	00300320	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 1755
# text = [Induction of apoptosis in lymphocytes by glucocorticoids: between physiology and pharmacology]
1	[	[	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
2	Induction	Induction	NOUN	NN	Number=Sing	_	_	_	_
3	of	of	ADP	IN	_	_	_	_	_
4	apoptosis	apoptosis	NOUN	NN	Number=Sing	_	_	_	_
5	in	in	ADP	IN	_	_	_	_	_
6	lymphocytes	lymphocyte	NOUN	NNS	Number=Plur	_	_	_	_
7	by	by	ADP	IN	_	_	_	_	_
8	glucocorticoids	glucocorticoid	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
9	:	:	PUNCT	:	_	_	_	_	_
10	between	between	ADP	IN	_	_	_	_	_
11	physiology	physiology	NOUN	NN	Number=Sing	_	_	_	_
12	and	and	CCONJ	CC	_	_	_	_	_
13	pharmacology	pharmacology	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
14	]	]	PUNCT	-RRB-	_	_	_	_	SpacesAfter=\s\n

# sent_id = 1756
# text = Glucocorticoids are physiological molecules that are also extensively used in clinics as anti-inflammatory, immunosuppressive or anti-tumoral agents.
1	Glucocorticoids	Glucocorticoid	NOUN	NNS	Number=Plur	_	_	_	_
2	are	be	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
3	physiological	physiological	ADJ	JJ	Degree=Pos	_	_	_	_
4	molecules	molecule	NOUN	NNS	Number=Plur	_	_	_	_
5	that	that	PRON	WDT	PronType=Rel	_	_	_	_
6	are	be	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
7	also	also	ADV	RB	_	_	_	_	_
8	extensively	extensively	ADV	RB	_	_	_	_	_
9	used	use	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
10	in	in	ADP	IN	_	_	_	_	_
11	clinics	clinic	NOUN	NNS	Number=Plur	_	_	_	_
12	as	as	ADP	IN	_	_	_	_	_
13	anti-inflammatory	anti-inflammatory	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
14	,	,	PUNCT	,	_	_	_	_	_
15	immunosuppressive	immunosuppressive	ADJ	JJ	Degree=Pos	_	_	_	_
16	or	or	CCONJ	CC	_	_	_	_	_
17	anti-tumoral	anti-tumoral	ADJ	JJ	Degree=Pos	_	_	_	_
18	agents	agent	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
19	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1757
# text = Glucocorticoids can induce apoptosis on normal lymphoid cells and play a key role in the physiology of thymic selection.
1	Glucocorticoids	Glucocorticoid	NOUN	NNS	Number=Plur	_	_	_	_
2	can	can	AUX	MD	VerbForm=Fin	_	_	_	_
3	induce	induce	VERB	VB	VerbForm=Inf	_	_	_	_
4	apoptosis	apoptosis	PRON	PRP$	Gender=Masc|Number=Sing|Person=3|Poss=Yes|PronType=Prs	_	_	_	_
5	on	on	ADP	IN	_	_	_	_	_
6	normal	normal	ADJ	JJ	Degree=Pos	_	_	_	_
7	lymphoid	lymphoid	ADJ	JJ	Degree=Pos	_	_	_	_
8	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
9	and	and	CCONJ	CC	_	_	_	_	_
10	play	play	VERB	VB	VerbForm=Inf	_	_	_	_
11	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
12	key	key	ADJ	JJ	Degree=Pos	_	_	_	_
13	role	role	NOUN	NN	Number=Sing	_	_	_	_
14	in	in	ADP	IN	_	_	_	_	_
15	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
16	physiology	physiology	NOUN	NN	Number=Sing	_	_	_	_
17	of	of	ADP	IN	_	_	_	_	_
18	thymic	thymic	ADJ	JJ	Degree=Pos	_	_	_	_
19	selection	selection	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
20	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1758
# text = In clinics these molecules are also used for their potencies in inducing apoptosis of malignant lymphoid cells.
1	In	in	ADP	IN	_	_	_	_	_
2	clinics	clinic	NOUN	NNS	Number=Plur	_	_	_	_
3	these	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
4	molecules	molecule	NOUN	NNS	Number=Plur	_	_	_	_
5	are	be	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
6	also	also	ADV	RB	_	_	_	_	_
7	used	use	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
8	for	for	ADP	IN	_	_	_	_	_
9	their	they	PRON	PRP$	Number=Plur|Person=3|Poss=Yes|PronType=Prs	_	_	_	_
10	potencies	potency	NOUN	NNS	Number=Plur	_	_	_	_
11	in	in	ADP	IN	_	_	_	_	_
12	inducing	induce	NOUN	NN	Number=Sing	_	_	_	_
13	apoptosis	apoptosis	NOUN	NN	Number=Sing	_	_	_	_
14	of	of	ADP	IN	_	_	_	_	_
15	malignant	malignant	ADJ	JJ	Degree=Pos	_	_	_	_
16	lymphoid	lymphoid	NOUN	NN	Number=Sing	_	_	_	_
17	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
18	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1759
# text = Glucocorticoids are mediating their effects after binding to an intracellular receptor belonging to the steroid receptor superfamily: the glucocorticoid receptor (GR).
1	Glucocorticoids	Glucocorticoid	NOUN	NNS	Number=Plur	_	_	_	_
2	are	be	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
3	mediating	mediat	VERB	VBG	Tense=Pres|VerbForm=Part	_	_	_	_
4	their	they	PRON	PRP$	Number=Plur|Person=3|Poss=Yes|PronType=Prs	_	_	_	_
5	effects	effect	NOUN	NNS	Number=Plur	_	_	_	_
6	after	after	SCONJ	IN	_	_	_	_	_
7	binding	bind	VERB	VBG	VerbForm=Ger	_	_	_	_
8	to	to	ADP	IN	_	_	_	_	_
9	an	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
10	intracellular	intracellular	ADJ	JJ	Degree=Pos	_	_	_	_
11	receptor	receptor	NOUN	NN	Number=Sing	_	_	_	_
12	belonging	belong	VERB	VBG	VerbForm=Ger	_	_	_	_
13	to	to	ADP	IN	_	_	_	_	_
14	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
15	steroid	steroid	NOUN	NN	Number=Sing	_	_	_	_
16	receptor	receptor	NOUN	NN	Number=Sing	_	_	_	_
17	superfamily	superfamily	ADV	RB	_	_	_	_	SpaceAfter=No
18	:	:	PUNCT	:	_	_	_	_	_
19	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
20	glucocorticoid	glucocorticoid	ADJ	JJ	Degree=Pos	_	_	_	_
21	receptor	receptor	NOUN	NN	Number=Sing	_	_	_	_
22	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
23	GR	GR	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
24	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
25	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1760
# text = Once activated, the GR, can mediate his effects through direct binding on the DNA or via protein/protein interactions with transcription factors.
1	Once	once	SCONJ	IN	_	_	_	_	_
2	activated	activate	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	SpaceAfter=No
3	,	,	PUNCT	,	_	_	_	_	_
4	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
5	GR	Gr	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
6	,	,	PUNCT	,	_	_	_	_	_
7	can	can	AUX	MD	VerbForm=Fin	_	_	_	_
8	mediate	mediate	VERB	VB	VerbForm=Inf	_	_	_	_
9	his	he	PRON	PRP$	Gender=Masc|Number=Sing|Person=3|Poss=Yes|PronType=Prs	_	_	_	_
10	effects	effect	NOUN	NNS	Number=Plur	_	_	_	_
11	through	through	ADP	IN	_	_	_	_	_
12	direct	direct	ADJ	JJ	Degree=Pos	_	_	_	_
13	binding	binding	VERB	VBG	VerbForm=Ger	_	_	_	_
14	on	on	ADP	IN	_	_	_	_	_
15	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
16	DNA	dna	NOUN	NN	Number=Sing	_	_	_	_
17	or	or	CCONJ	CC	_	_	_	_	_
18	via	via	ADP	IN	_	_	_	_	_
19	protein	protein	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
20	/	/	PUNCT	,	_	_	_	_	SpaceAfter=No
21	protein	protein	NOUN	NN	Number=Sing	_	_	_	_
22	interactions	interaction	NOUN	NNS	Number=Plur	_	_	_	_
23	with	with	ADP	IN	_	_	_	_	_
24	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
25	factors	factor	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
26	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1761
# text = Depending on the type of lymphocytes, the mechanism of apoptosis induced by glucocorticoids fall roughly in two categories: induction of "death genes" by the activated GR (I kappa B, c-jun) or repression of survival factors (AP-1, c-Myc).
1	Depending	depend	VERB	VBG	VerbForm=Ger	_	_	_	_
2	on	on	ADP	IN	_	_	_	_	_
3	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
4	type	type	NOUN	NN	Number=Sing	_	_	_	_
5	of	of	ADP	IN	_	_	_	_	_
6	lymphocytes	lymphocyte	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
7	,	,	PUNCT	,	_	_	_	_	_
8	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
9	mechanism	mechanism	NOUN	NN	Number=Sing	_	_	_	_
10	of	of	ADP	IN	_	_	_	_	_
11	apoptosis	apoptosis	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
12	induced	induce	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
13	by	by	ADP	IN	_	_	_	_	_
14	glucocorticoids	glucocorticoid	NOUN	NNS	Number=Plur	_	_	_	_
15	fall	fall	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
16	roughly	roughly	ADV	RB	_	_	_	_	_
17	in	in	ADP	IN	_	_	_	_	_
18	two	two	NUM	CD	NumType=Card	_	_	_	_
19	categories	category	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
20	:	:	PUNCT	:	_	_	_	_	_
21	induction	induction	NOUN	NN	Number=Sing	_	_	_	_
22	of	of	ADP	IN	_	_	_	_	_
23	"	"	PUNCT	``	_	_	_	_	SpaceAfter=No
24	death	death	NOUN	NN	Number=Sing	_	_	_	_
25	genes	gene	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
26	"	"	PUNCT	''	_	_	_	_	_
27	by	by	ADP	IN	_	_	_	_	_
28	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
29	activated	activate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
30	GR	Gr	NOUN	NN	Number=Sing	_	_	_	_
31	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
32	I	I	PRON	PRP	Case=Nom|Number=Sing|Person=1|PronType=Prs	_	_	_	_
33	kappa	kappa	PROPN	NNP	Number=Sing	_	_	_	_
34	B	B	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
35	,	,	PUNCT	,	_	_	_	_	_
36	c-	c-	SYM	NFP	_	_	_	_	SpaceAfter=No
37	jun	jun	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
38	)	)	PUNCT	-RRB-	_	_	_	_	_
39	or	or	CCONJ	CC	_	_	_	_	_
40	repression	repression	NOUN	NN	Number=Sing	_	_	_	_
41	of	of	ADP	IN	_	_	_	_	_
42	survival	survival	NOUN	NN	Number=Sing	_	_	_	_
43	factors	factor	NOUN	NNS	Number=Plur	_	_	_	_
44	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
45	AP	ap	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
46	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
47	1	1	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
48	,	,	PUNCT	,	_	_	_	_	_
49	c	c	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
50	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
51	Myc	Myc	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
52	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
53	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1762
# text = In the case of thymic selection the mechanism is more subtle depending on the mutual repression of Nur77 and GR.
1	In	in	ADP	IN	_	_	_	_	_
2	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
3	case	case	NOUN	NN	Number=Sing	_	_	_	_
4	of	of	ADP	IN	_	_	_	_	_
5	thymic	thymic	ADJ	JJ	Degree=Pos	_	_	_	_
6	selection	selection	NOUN	NN	Number=Sing	_	_	_	_
7	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
8	mechanism	mechanism	NOUN	NN	Number=Sing	_	_	_	_
9	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
10	more	more	ADV	RBR	_	_	_	_	_
11	subtle	subtle	ADJ	JJ	Degree=Pos	_	_	_	_
12	depending	depend	VERB	VBG	VerbForm=Ger	_	_	_	_
13	on	on	ADP	IN	_	_	_	_	_
14	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
15	mutual	mutual	ADJ	JJ	Degree=Pos	_	_	_	_
16	repression	repression	NOUN	NN	Number=Sing	_	_	_	_
17	of	of	ADP	IN	_	_	_	_	_
18	Nur77	Nur77	NUM	CD	NumType=Card	_	_	_	_
19	and	and	CCONJ	CC	_	_	_	_	_
20	GR	Gr	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
21	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 1763
# text = Document 00300324 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	00300324	00300324	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 1764
# text = Phosphorylation of the transcription factor NFATp inhibits its DNA binding activity in cyclosporin A-treated human B and T cells.
1	Phosphorylation	Phosphorylation	NOUN	NN	Number=Sing	_	_	_	_
2	of	of	ADP	IN	_	_	_	_	_
3	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
4	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
5	factor	factor	NOUN	NN	Number=Sing	_	_	_	_
6	NFATp	NFATp	PROPN	NNP	Number=Sing	_	_	_	_
7	inhibits	inhibit	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
8	its	its	PRON	PRP$	Gender=Neut|Number=Sing|Person=3|Poss=Yes|PronType=Prs	_	_	_	_
9	DNA	dna	NOUN	NN	Number=Sing	_	_	_	_
10	binding	binde	VERB	VBG	VerbForm=Ger	_	_	_	_
11	activity	activity	NOUN	NN	Number=Sing	_	_	_	_
12	in	in	ADP	IN	_	_	_	_	_
13	cyclosporin	cyclosporin	NOUN	NN	Number=Sing	_	_	_	_
14	A	a	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
15	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
16	treated	treat	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
17	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
18	B	b	NOUN	NN	Number=Sing	_	_	_	_
19	and	and	CCONJ	CC	_	_	_	_	_
20	T	t	PROPN	NNP	Number=Sing	_	_	_	_
21	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
22	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 1765
# text = Cyclosporin A (CsA) exerts its immunosuppressive effect by inhibiting the activity of nuclear factor of activated T cells (NFAT), thus preventing transcriptional induction of several cytokine genes.
1	Cyclosporin	Cyclosporin	PROPN	NNP	Number=Sing	_	_	_	_
2	A	a	PROPN	NNP	Number=Sing	_	_	_	_
3	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
4	CsA	csa	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
5	)	)	PUNCT	-RRB-	_	_	_	_	_
6	exerts	exert	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
7	its	its	PRON	PRP$	Gender=Neut|Number=Sing|Person=3|Poss=Yes|PronType=Prs	_	_	_	_
8	immunosuppressive	immunosuppressive	ADJ	JJ	Degree=Pos	_	_	_	_
9	effect	effect	NOUN	NN	Number=Sing	_	_	_	_
10	by	by	SCONJ	IN	_	_	_	_	_
11	inhibiting	inhibit	VERB	VBG	VerbForm=Ger	_	_	_	_
12	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
13	activity	activity	NOUN	NN	Number=Sing	_	_	_	_
14	of	of	ADP	IN	_	_	_	_	_
15	nuclear	nuclear	ADJ	JJ	Degree=Pos	_	_	_	_
16	factor	factor	NOUN	NN	Number=Sing	_	_	_	_
17	of	of	ADP	IN	_	_	_	_	_
18	activated	activate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
19	T	t	PROPN	NNP	Number=Sing	_	_	_	_
20	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
21	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
22	NFAT	NFAT	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
23	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
24	,	,	PUNCT	,	_	_	_	_	_
25	thus	thus	ADV	RB	_	_	_	_	_
26	preventing	prevent	VERB	VBG	VerbForm=Ger	_	_	_	_
27	transcriptional	transcriptional	ADJ	JJ	Degree=Pos	_	_	_	_
28	induction	induction	NOUN	NN	Number=Sing	_	_	_	_
29	of	of	ADP	IN	_	_	_	_	_
30	several	several	ADJ	JJ	Degree=Pos	_	_	_	_
31	cytokine	cytokine	NOUN	NN	Number=Sing	_	_	_	_
32	genes	gene	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
33	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1766
# text = This effect is thought to be largely mediated through inactivation of the phosphatase calcineurin, which in turn inhibits translocation of an NFAT component to the nucleus.
1	This	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
2	effect	effect	NOUN	NN	Number=Sing	_	_	_	_
3	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
4	thought	think	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
5	to	to	PART	TO	_	_	_	_	_
6	be	be	AUX	VB	VerbForm=Inf	_	_	_	_
7	largely	largely	ADV	RB	_	_	_	_	_
8	mediated	mediate	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
9	through	through	ADP	IN	_	_	_	_	_
10	inactivation	inactivation	NOUN	NN	Number=Sing	_	_	_	_
11	of	of	ADP	IN	_	_	_	_	_
12	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
13	phosphatase	phosphatase	NOUN	NN	Number=Sing	_	_	_	_
14	calcineurin	calcineurin	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
15	,	,	PUNCT	,	_	_	_	_	_
16	which	which	PRON	WDT	PronType=Rel	_	_	_	_
17	in	in	ADP	IN	_	_	_	_	_
18	turn	turn	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
19	inhibits	inhibit	NOUN	NNS	Number=Plur	_	_	_	_
20	translocation	translocation	NOUN	NN	Number=Sing	_	_	_	_
21	of	of	ADP	IN	_	_	_	_	_
22	an	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
23	NFAT	Nfat	ADJ	JJ	Degree=Pos	_	_	_	_
24	component	component	NOUN	NN	Number=Sing	_	_	_	_
25	to	to	ADP	IN	_	_	_	_	_
26	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
27	nucleus	nucleus	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
28	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1767
# text = Here we report that CsA treatment of Raji B and Jurkat T cell lines yields a phosphorylated form of NFATp that is inhibited in DNA-binding and in its ability to form an NFAT complex with Fos and Jun.
1	Here	here	ADV	RB	PronType=Dem	_	_	_	_
2	we	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
3	report	report	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
4	that	that	SCONJ	IN	_	_	_	_	_
5	CsA	csa	PROPN	NNP	Number=Sing	_	_	_	_
6	treatment	treatment	NOUN	NN	Number=Sing	_	_	_	_
7	of	of	ADP	IN	_	_	_	_	_
8	Raji	Raji	PROPN	NNP	Number=Sing	_	_	_	_
9	B	b	PROPN	NNP	Number=Sing	_	_	_	_
10	and	and	CCONJ	CC	_	_	_	_	_
11	Jurkat	Jurkat	PROPN	NNP	Number=Sing	_	_	_	_
12	T	T	PROPN	NNP	Number=Sing	_	_	_	_
13	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
14	lines	line	NOUN	NNS	Number=Plur	_	_	_	_
15	yields	yield	ADP	IN	_	_	_	_	_
16	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
17	phosphorylated	phosphorylate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
18	form	form	NOUN	NN	Number=Sing	_	_	_	_
19	of	of	ADP	IN	_	_	_	_	_
20	NFATp	NFATp	PROPN	NNP	Number=Sing	_	_	_	_
21	that	that	PRON	WDT	PronType=Rel	_	_	_	_
22	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
23	inhibited	inhibit	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
24	in	in	ADP	IN	_	_	_	_	_
25	DNA	dna	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
26	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
27	binding	binding	VERB	VBG	VerbForm=Ger	_	_	_	_
28	and	and	CCONJ	CC	_	_	_	_	_
29	in	in	ADP	IN	_	_	_	_	_
30	its	its	PRON	PRP$	Gender=Neut|Number=Sing|Person=3|Poss=Yes|PronType=Prs	_	_	_	_
31	ability	ability	NOUN	NN	Number=Sing	_	_	_	_
32	to	to	PART	TO	_	_	_	_	_
33	form	form	VERB	VB	VerbForm=Inf	_	_	_	_
34	an	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
35	NFAT	Nfat	ADJ	JJ	Degree=Pos	_	_	_	_
36	complex	complex	NOUN	NN	Number=Sing	_	_	_	_
37	with	with	ADP	IN	_	_	_	_	_
38	Fos	Fos	PROPN	NNP	Number=Sing	_	_	_	_
39	and	and	CCONJ	CC	_	_	_	_	_
40	Jun	Jun	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
41	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1768
# text = Immunoblot analyses and metabolic labeling with [32P]orthophosphate show that CsA alters NFATp migration on SDS-polyacrylamide gel electrophoresis by increasing its phosphorylation level without affecting subcellular distribution.
1	Immunoblot	Immunoblot	ADJ	JJ	Degree=Pos	_	_	_	_
2	analyses	analysis	NOUN	NNS	Number=Plur	_	_	_	_
3	and	and	CCONJ	CC	_	_	_	_	_
4	metabolic	metabolic	ADJ	JJ	Degree=Pos	_	_	_	_
5	labeling	labeling	NOUN	NN	Number=Sing	_	_	_	_
6	with	with	ADP	IN	_	_	_	_	_
7	[	[	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
8	32P]	32P]	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
9	orthophosphate	orthophosphate	ADJ	JJ	Degree=Pos	_	_	_	_
10	show	show	NOUN	NN	Number=Sing	_	_	_	_
11	that	that	PRON	WDT	PronType=Rel	_	_	_	_
12	CsA	csa	PROPN	NNP	Number=Sing	_	_	_	_
13	alters	alter	PROPN	NNPS	Number=Plur	_	_	_	_
14	NFATp	NFATp	PROPN	NNP	Number=Sing	_	_	_	_
15	migration	migration	NOUN	NN	Number=Sing	_	_	_	_
16	on	on	ADP	IN	_	_	_	_	_
17	SDS	SDS	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
18	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
19	polyacrylamide	polyacrylamide	NOUN	NN	Number=Sing	_	_	_	_
20	gel	gel	NOUN	NN	Number=Sing	_	_	_	_
21	electrophoresis	electrophoresis	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
22	by	by	SCONJ	IN	_	_	_	_	_
23	increasing	increase	VERB	VBG	VerbForm=Ger	_	_	_	_
24	its	its	PRON	PRP$	Gender=Neut|Number=Sing|Person=3|Poss=Yes|PronType=Prs	_	_	_	_
25	phosphorylation	phosphorylation	NOUN	NN	Number=Sing	_	_	_	_
26	level	level	NOUN	NN	Number=Sing	_	_	_	_
27	without	without	SCONJ	IN	_	_	_	_	_
28	affecting	affect	VERB	VBG	VerbForm=Ger	_	_	_	_
29	subcellular	subcellular	ADJ	JJ	Degree=Pos	_	_	_	_
30	distribution	distribution	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
31	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1769
# text = Dephosphorylation by in vitro treatment with calcineurin or alkaline phosphatase restores NFATp DNA binding activity and its ability to reconstitute an NFAT complex with Fos and Jun proteins.
1	Dephosphorylation	Dephosphorylation	NOUN	NN	Number=Sing	_	_	_	_
2	by	by	ADP	IN	_	_	_	_	_
3	in	in	ADP	IN	_	_	_	_	_
4	vitro	vitro	ADJ	JJ	Degree=Pos	_	_	_	_
5	treatment	treatment	NOUN	NN	Number=Sing	_	_	_	_
6	with	with	ADP	IN	_	_	_	_	_
7	calcineurin	calcineurin	NOUN	NN	Number=Sing	_	_	_	_
8	or	or	CCONJ	CC	_	_	_	_	_
9	alkaline	alkaline	NOUN	NN	Number=Sing	_	_	_	_
10	phosphatase	phosphatase	NOUN	NN	Number=Sing	_	_	_	_
11	restores	restore	NOUN	NNS	Number=Plur	_	_	_	_
12	NFATp	NFATp	PROPN	NNP	Number=Sing	_	_	_	_
13	DNA	dna	PROPN	NNP	Number=Sing	_	_	_	_
14	binding	binde	VERB	VBG	VerbForm=Ger	_	_	_	_
15	activity	activity	NOUN	NN	Number=Sing	_	_	_	_
16	and	and	CCONJ	CC	_	_	_	_	_
17	its	its	PRON	PRP$	Gender=Neut|Number=Sing|Person=3|Poss=Yes|PronType=Prs	_	_	_	_
18	ability	ability	NOUN	NN	Number=Sing	_	_	_	_
19	to	to	PART	TO	_	_	_	_	_
20	reconstitute	reconstitute	VERB	VB	VerbForm=Inf	_	_	_	_
21	an	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
22	NFAT	Nfat	ADJ	JJ	Degree=Pos	_	_	_	_
23	complex	complex	NOUN	NN	Number=Sing	_	_	_	_
24	with	with	ADP	IN	_	_	_	_	_
25	Fos	Fos	PROPN	NNP	Number=Sing	_	_	_	_
26	and	and	CCONJ	CC	_	_	_	_	_
27	Jun	Jun	PROPN	NNP	Number=Sing	_	_	_	_
28	proteins	protein	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
29	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1770
# text = These data point to a new mechanism for CsA-sensitive regulation of NFATp in which dephosphorylation is critical for DNA binding.
1	These	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
2	data	data	NOUN	NN	Number=Sing	_	_	_	_
3	point	point	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
4	to	to	ADP	IN	_	_	_	_	_
5	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
6	new	new	ADJ	JJ	Degree=Pos	_	_	_	_
7	mechanism	mechanism	NOUN	NN	Number=Sing	_	_	_	_
8	for	for	ADP	IN	_	_	_	_	_
9	CsA	csa	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
10	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
11	sensitive	sensitive	ADJ	JJ	Degree=Pos	_	_	_	_
12	regulation	regulation	NOUN	NN	Number=Sing	_	_	_	_
13	of	of	ADP	IN	_	_	_	_	_
14	NFATp	NFATp	PROPN	NNP	Number=Sing	_	_	_	_
15	in	in	ADP	IN	_	_	_	_	_
16	which	which	PRON	WDT	PronType=Rel	_	_	_	_
17	dephosphorylation	dephosphorylation	NOUN	NN	Number=Sing	_	_	_	_
18	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
19	critical	critical	ADJ	JJ	Degree=Pos	_	_	_	_
20	for	for	ADP	IN	_	_	_	_	_
21	DNA	dna	NOUN	NN	Number=Sing	_	_	_	_
22	binding	binding	VERB	VBG	VerbForm=Ger	_	_	_	SpaceAfter=No
23	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 1771
# text = Document 00300327 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	00300327	00300327	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 1772
# text = A mutation of the glucocorticoid receptor in primary cortisol resistance.
1	A	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
2	mutation	mutation	NOUN	NN	Number=Sing	_	_	_	_
3	of	of	ADP	IN	_	_	_	_	_
4	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
5	glucocorticoid	glucocorticoid	ADJ	JJ	Degree=Pos	_	_	_	_
6	receptor	receptor	NOUN	NN	Number=Sing	_	_	_	_
7	in	in	ADP	IN	_	_	_	_	_
8	primary	primary	ADJ	JJ	Degree=Pos	_	_	_	_
9	cortisol	cortisol	NOUN	NN	Number=Sing	_	_	_	_
10	resistance	resistance	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
11	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 1773
# text = The precise molecular abnormalities that cause primary cortisol resistance have not been completely described.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	precise	precise	ADJ	JJ	Degree=Pos	_	_	_	_
3	molecular	molecular	ADJ	JJ	Degree=Pos	_	_	_	_
4	abnormalities	abnormality	NOUN	NNS	Number=Plur	_	_	_	_
5	that	that	PRON	WDT	PronType=Rel	_	_	_	_
6	cause	cause	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
7	primary	primary	ADJ	JJ	Degree=Pos	_	_	_	_
8	cortisol	cortisol	NOUN	NN	Number=Sing	_	_	_	_
9	resistance	resistance	NOUN	NN	Number=Sing	_	_	_	_
10	have	have	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
11	not	not	PART	RB	_	_	_	_	_
12	been	be	AUX	VBN	Tense=Past|VerbForm=Part	_	_	_	_
13	completely	completely	ADV	RB	_	_	_	_	_
14	described	describe	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	SpaceAfter=No
15	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1774
# text = In a subject with primary cortisol resistance we have observed glucocorticoid receptors (hGR) with a decreased affinity for dexamethasone.
1	In	in	ADP	IN	_	_	_	_	_
2	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
3	subject	subject	NOUN	NN	Number=Sing	_	_	_	_
4	with	with	ADP	IN	_	_	_	_	_
5	primary	primary	ADJ	JJ	Degree=Pos	_	_	_	_
6	cortisol	cortisol	NOUN	NN	Number=Sing	_	_	_	_
7	resistance	resistance	NOUN	NN	Number=Sing	_	_	_	_
8	we	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
9	have	have	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
10	observed	observe	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
11	glucocorticoid	glucocorticoid	ADJ	JJ	Degree=Pos	_	_	_	_
12	receptors	receptor	NOUN	NNS	Number=Plur	_	_	_	_
13	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
14	hGR	hGR	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
15	)	)	PUNCT	-RRB-	_	_	_	_	_
16	with	with	ADP	IN	_	_	_	_	_
17	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
18	decreased	decrease	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
19	affinity	affinity	NOUN	NN	Number=Sing	_	_	_	_
20	for	for	ADP	IN	_	_	_	_	_
21	dexamethasone	dexamethasone	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
22	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1775
# text = We hypothesize that a mutation of the hGR glucocorticoid-binding domain is the cause of cortisol resistance.
1	We	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
2	hypothesize	hypothesize	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
3	that	that	SCONJ	IN	_	_	_	_	_
4	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
5	mutation	mutation	NOUN	NN	Number=Sing	_	_	_	_
6	of	of	ADP	IN	_	_	_	_	_
7	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
8	hGR	hGR	PROPN	NNP	Number=Sing	_	_	_	_
9	glucocorticoid	glucocorticoid	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
10	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
11	binding	binding	VERB	VBG	VerbForm=Ger	_	_	_	_
12	domain	domain	NOUN	NN	Number=Sing	_	_	_	_
13	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
14	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
15	cause	cause	NOUN	NN	Number=Sing	_	_	_	_
16	of	of	ADP	IN	_	_	_	_	_
17	cortisol	cortisol	NOUN	NN	Number=Sing	_	_	_	_
18	resistance	resistance	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
19	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1776
# text = Total RNA isolated from the index subject's mononuclear leukocytes was used to produce first strand hGR cDNAs, and the entire hGR cDNA was amplified in segments and sequenced.
1	Total	total	PROPN	NNP	Number=Sing	_	_	_	_
2	RNA	RNa	PROPN	NNP	Number=Sing	_	_	_	_
3	isolated	isolate	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
4	from	from	ADP	IN	_	_	_	_	_
5	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
6	index	index	NOUN	NN	Number=Sing	_	_	_	_
7	subject	subject	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
8	's	's	PART	POS	_	_	_	_	_
9	mononuclear	mononuclear	ADJ	JJ	Degree=Pos	_	_	_	_
10	leukocytes	leukocyte	NOUN	NNS	Number=Plur	_	_	_	_
11	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
12	used	use	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
13	to	to	PART	TO	_	_	_	_	_
14	produce	produce	VERB	VB	VerbForm=Inf	_	_	_	_
15	first	first	ADJ	JJ	Degree=Pos|NumType=Ord	_	_	_	_
16	strand	strand	NOUN	NN	Number=Sing	_	_	_	_
17	hGR	hgr	ADP	IN	_	_	_	_	_
18	cDNAs	cDNA	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
19	,	,	PUNCT	,	_	_	_	_	_
20	and	and	CCONJ	CC	_	_	_	_	_
21	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
22	entire	entire	ADJ	JJ	Degree=Pos	_	_	_	_
23	hGR	hgr	NOUN	NN	Number=Sing	_	_	_	_
24	cDNA	cDNa	NOUN	NN	Number=Sing	_	_	_	_
25	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
26	amplified	amplify	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
27	in	in	ADP	IN	_	_	_	_	_
28	segments	segment	NOUN	NNS	Number=Plur	_	_	_	_
29	and	and	CCONJ	CC	_	_	_	_	_
30	sequenced	sequence	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	SpaceAfter=No
31	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1777
# text = At nucleotide 2,317 we identified a homozygous A for G point mutation that predicts an isoleucine (ATT) for valine (GTT) substitution at amino acid 729.
1	At	at	ADP	IN	_	_	_	_	_
2	nucleotide	nucleotide	ADV	RB	_	_	_	_	_
3	2,317	2,317	NUM	CD	NumType=Card	_	_	_	_
4	we	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
5	identified	identify	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
6	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
7	homozygous	homozygous	ADJ	JJ	Degree=Pos	_	_	_	_
8	A	a	NOUN	NN	Number=Sing	_	_	_	_
9	for	for	ADP	IN	_	_	_	_	_
10	G	G	ADJ	JJ	Degree=Pos	_	_	_	_
11	point	point	NOUN	NN	Number=Sing	_	_	_	_
12	mutation	mutation	NOUN	NN	Number=Sing	_	_	_	_
13	that	that	PRON	WDT	PronType=Rel	_	_	_	_
14	predicts	predict	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
15	an	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
16	isoleucine	isoleucine	NOUN	NN	Number=Sing	_	_	_	_
17	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
18	ATT	ATT	X	ADD	_	_	_	_	SpaceAfter=No
19	)	)	PUNCT	-RRB-	_	_	_	_	_
20	for	for	ADP	IN	_	_	_	_	_
21	valine	valine	NOUN	NN	Number=Sing	_	_	_	_
22	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
23	GTT	GTT	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
24	)	)	PUNCT	-RRB-	_	_	_	_	_
25	substitution	substitution	NOUN	NN	Number=Sing	_	_	_	_
26	at	at	ADP	IN	_	_	_	_	_
27	amino	amino	DET	DT	_	_	_	_	_
28	acid	acid	NOUN	NN	Number=Sing	_	_	_	_
29	729	729	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
30	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1778
# text = When the wild-type hGR and hGR-Ile 729 were expressed in COS-1 cells and assayed for [3H]-Dexamethasone binding, the dissociation constants were 0.799 +/- 0.068 and 1.54 +/- 0.06 nM
1	When	when	ADV	WRB	PronType=Int	_	_	_	_
2	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
3	wild	wild	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
4	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
5	type	type	NOUN	NN	Number=Sing	_	_	_	_
6	hGR	hgr	NOUN	NN	Number=Sing	_	_	_	_
7	and	and	CCONJ	CC	_	_	_	_	_
8	hGR-	hGR-	SYM	NFP	_	_	_	_	SpaceAfter=No
9	Ile	Ile	PROPN	NNP	Number=Sing	_	_	_	_
10	729	729	NUM	CD	NumType=Card	_	_	_	_
11	were	be	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
12	expressed	express	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
13	in	in	ADP	IN	_	_	_	_	_
14	COS	COS	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
15	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
16	1	1	NUM	CD	NumType=Card	_	_	_	_
17	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
18	and	and	CCONJ	CC	_	_	_	_	_
19	assayed	assay	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
20	for	for	ADP	IN	_	_	_	_	_
21	[	[	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
22	3	3	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
23	H	h	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
24	]	]	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
25	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
26	Dexamethasone	Dexamethasone	PROPN	NNP	Number=Sing	_	_	_	_
27	binding	binding	VERB	VBG	VerbForm=Ger	_	_	_	SpaceAfter=No
28	,	,	PUNCT	,	_	_	_	_	_
29	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
30	dissociation	dissociation	NOUN	NN	Number=Sing	_	_	_	_
31	constants	constant	NOUN	NNS	Number=Plur	_	_	_	_
32	were	be	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
33	0.799	0.799	NUM	CD	NumType=Card	_	_	_	_
34	+/-	+/-	SYM	SYM	_	_	_	_	_
35	0.068	0.068	NUM	CD	NumType=Card	_	_	_	_
36	and	and	CCONJ	CC	_	_	_	_	_
37	1.54	1.54	NUM	CD	NumType=Card	_	_	_	_
38	+/-	+/-	SYM	SYM	_	_	_	_	_
39	0.06	0.06	NUM	CD	NumType=Card	_	_	_	_
40	nM	nm	NOUN	NN	Number=Sing	_	_	_	_

# sent_id = 1779
# text = (mean +/- SEM) (P < 0.01), respectively.
1	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
2	mean	mean	X	GW	_	_	_	_	_
3	+/-	+/-	X	GW	_	_	_	_	_
4	SEM	SEm	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
5	)	)	PUNCT	-RRB-	_	_	_	_	_
6	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
7	P	p	NOUN	NN	Number=Sing	_	_	_	_
8	<	<	PUNCT	-LRB-	_	_	_	_	_
9	0.01	0.01	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
10	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
11	,	,	PUNCT	,	_	_	_	_	_
12	respectively	respectively	ADV	RB	_	_	_	_	SpaceAfter=No
13	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1780
# text = When the wild-type hGR and hGR-Ile 729 were expressed in CV-1 cells that were cotransfected with the mouse mammary tumor virus long terminal repeat fused to the chloramphenicol acetyl transferase (CAT) gene, the hGR-Ile 729 conferred a fourfold decrease in apparent potency on dexamethasone stimulation of CAT activity.
1	When	when	ADV	WRB	PronType=Int	_	_	_	_
2	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
3	wild	wild	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
4	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
5	type	type	NOUN	NN	Number=Sing	_	_	_	_
6	hGR	hgr	NOUN	NN	Number=Sing	_	_	_	_
7	and	and	CCONJ	CC	_	_	_	_	_
8	hGR-	hGR-	SYM	NFP	_	_	_	_	SpaceAfter=No
9	Ile	Ile	PROPN	NNP	Number=Sing	_	_	_	_
10	729	729	NUM	CD	NumType=Card	_	_	_	_
11	were	be	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
12	expressed	express	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
13	in	in	ADP	IN	_	_	_	_	_
14	CV	CV	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
15	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
16	1	1	NUM	CD	NumType=Card	_	_	_	_
17	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
18	that	that	PRON	WDT	PronType=Rel	_	_	_	_
19	were	be	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
20	cotransfected	cotransfect	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
21	with	with	ADP	IN	_	_	_	_	_
22	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
23	mouse	mouse	NOUN	NN	Number=Sing	_	_	_	_
24	mammary	mammary	NOUN	NN	Number=Sing	_	_	_	_
25	tumor	tumor	NOUN	NN	Number=Sing	_	_	_	_
26	virus	virus	NOUN	NN	Number=Sing	_	_	_	_
27	long	long	ADV	RB	Degree=Pos	_	_	_	_
28	terminal	terminal	ADJ	JJ	Degree=Pos	_	_	_	_
29	repeat	repeat	NOUN	NN	Number=Sing	_	_	_	_
30	fused	fuse	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
31	to	to	ADP	IN	_	_	_	_	_
32	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
33	chloramphenicol	chloramphenicol	NOUN	NN	Number=Sing	_	_	_	_
34	acetyl	acetyl	NOUN	NN	Number=Sing	_	_	_	_
35	transferase	transferase	NOUN	NN	Number=Sing	_	_	_	_
36	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
37	CAT	cat	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
38	)	)	PUNCT	-RRB-	_	_	_	_	_
39	gene	gene	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
40	,	,	PUNCT	,	_	_	_	_	_
41	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
42	hGR-	hGR-	X	AFX	_	_	_	_	SpaceAfter=No
43	Ile	Ile	PROPN	NNP	Number=Sing	_	_	_	_
44	729	729	NUM	CD	NumType=Card	_	_	_	_
45	conferred	confer	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
46	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
47	fourfold	fourfold	ADJ	JJ	Degree=Pos	_	_	_	_
48	decrease	decrease	NOUN	NN	Number=Sing	_	_	_	_
49	in	in	ADP	IN	_	_	_	_	_
50	apparent	apparent	ADJ	JJ	Degree=Pos	_	_	_	_
51	potency	potency	NOUN	NN	Number=Sing	_	_	_	_
52	on	on	ADP	IN	_	_	_	_	_
53	dexamethasone	dexamethasone	NOUN	NN	Number=Sing	_	_	_	_
54	stimulation	stimulation	NOUN	NN	Number=Sing	_	_	_	_
55	of	of	ADP	IN	_	_	_	_	_
56	CAT	Cat	ADJ	JJ	Degree=Pos	_	_	_	_
57	activity	activity	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
58	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1781
# text = The isoleucine for valine substitution at amino acid 729 impairs the function of the hGR and is the likely cause of primary cortisol resistance in this subject.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	isoleucine	isoleucine	NOUN	NN	Number=Sing	_	_	_	_
3	for	for	ADP	IN	_	_	_	_	_
4	valine	valine	NOUN	NN	Number=Sing	_	_	_	_
5	substitution	substitution	NOUN	NN	Number=Sing	_	_	_	_
6	at	at	ADP	IN	_	_	_	_	_
7	amino	amino	DET	DT	_	_	_	_	_
8	acid	acid	ADJ	JJ	Degree=Pos	_	_	_	_
9	729	729	NUM	CD	NumType=Card	_	_	_	_
10	impairs	impair	NOUN	NNS	Number=Plur	_	_	_	_
11	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
12	function	function	NOUN	NN	Number=Sing	_	_	_	_
13	of	of	ADP	IN	_	_	_	_	_
14	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
15	hGR	hgr	PROPN	NNP	Number=Sing	_	_	_	_
16	and	and	CCONJ	CC	_	_	_	_	_
17	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
18	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
19	likely	likely	ADJ	JJ	Degree=Pos	_	_	_	_
20	cause	cause	NOUN	NN	Number=Sing	_	_	_	_
21	of	of	ADP	IN	_	_	_	_	_
22	primary	primary	ADJ	JJ	Degree=Pos	_	_	_	_
23	cortisol	cortisol	NOUN	NN	Number=Sing	_	_	_	_
24	resistance	resistance	NOUN	NN	Number=Sing	_	_	_	_
25	in	in	ADP	IN	_	_	_	_	_
26	this	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
27	subject	subject	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
28	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 1782
# text = Document 00300340 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	00300340	00300340	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 1783
# text = Expression and role of PML gene in normal adult hematopoiesis: functional interaction between PML and Rb proteins in erythropoiesis.
1	Expression	expression	NOUN	NN	Number=Sing	_	_	_	_
2	and	and	CCONJ	CC	_	_	_	_	_
3	role	role	NOUN	NN	Number=Sing	_	_	_	_
4	of	of	ADP	IN	_	_	_	_	_
5	PML	pMl	ADJ	JJ	Degree=Pos	_	_	_	_
6	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
7	in	in	ADP	IN	_	_	_	_	_
8	normal	normal	ADJ	JJ	Degree=Pos	_	_	_	_
9	adult	adult	NOUN	NN	Number=Sing	_	_	_	_
10	hematopoiesis	hematopoiesis	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
11	:	:	PUNCT	:	_	_	_	_	_
12	functional	functional	ADJ	JJ	Degree=Pos	_	_	_	_
13	interaction	interaction	NOUN	NN	Number=Sing	_	_	_	_
14	between	between	ADP	IN	_	_	_	_	_
15	PML	PML	PROPN	NNP	Number=Sing	_	_	_	_
16	and	and	CCONJ	CC	_	_	_	_	_
17	Rb	Rb	PROPN	NNP	Number=Sing	_	_	_	_
18	proteins	protein	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
19	in	in	ADP	IN	_	_	_	_	_
20	erythropoiesis	erythropoiesis	PRON	DT	Number=Sing|PronType=Dem	_	_	_	SpaceAfter=No
21	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 1784
# text = The expression of the PML gene was investigated in purified early hematopoietic progenitor cells (HPCs) induced to unilineage erythroid or granulocytic differentiation.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
3	of	of	ADP	IN	_	_	_	_	_
4	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
5	PML	PML	PROPN	NNP	Number=Sing	_	_	_	_
6	gene	gene	PROPN	NNP	Number=Sing	_	_	_	_
7	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
8	investigated	investigate	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
9	in	in	ADP	IN	_	_	_	_	_
10	purified	purify	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
11	early	early	ADV	RB	Degree=Pos	_	_	_	_
12	hematopoietic	hematopoietic	ADJ	JJ	Degree=Pos	_	_	_	_
13	progenitor	progenitor	NOUN	NN	Number=Sing	_	_	_	_
14	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
15	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
16	HPCs	HPC	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
17	)	)	PUNCT	-RRB-	_	_	_	_	_
18	induced	induce	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
19	to	to	ADP	IN	_	_	_	_	_
20	unilineage	unilineage	NOUN	NN	Number=Sing	_	_	_	_
21	erythroid	erythroid	NOUN	NN	Number=Sing	_	_	_	_
22	or	or	CCONJ	CC	_	_	_	_	_
23	granulocytic	granulocytic	ADJ	JJ	Degree=Pos	_	_	_	_
24	differentiation	differentiation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
25	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1785
# text = PML mRNA and protein, while barely detectable in quiescent HPCs, are consistently induced by growth factor stimulation through the erythroid or granulocytic lineage.
1	PML	PML	PROPN	NNP	Number=Sing	_	_	_	_
2	mRNA	mRNA	PROPN	NNP	Number=Sing	_	_	_	_
3	and	and	CCONJ	CC	_	_	_	_	_
4	protein	protein	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
5	,	,	PUNCT	,	_	_	_	_	_
6	while	while	SCONJ	IN	_	_	_	_	_
7	barely	barely	ADV	RB	_	_	_	_	_
8	detectable	detectable	ADJ	JJ	Degree=Pos	_	_	_	_
9	in	in	ADP	IN	_	_	_	_	_
10	quiescent	quiescent	ADJ	JJ	Degree=Pos	_	_	_	_
11	HPCs	HPC	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
12	,	,	PUNCT	,	_	_	_	_	_
13	are	be	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
14	consistently	consistently	ADV	RB	_	_	_	_	_
15	induced	induce	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
16	by	by	ADP	IN	_	_	_	_	_
17	growth	growth	NOUN	NN	Number=Sing	_	_	_	_
18	factor	factor	NOUN	NN	Number=Sing	_	_	_	_
19	stimulation	stimulation	NOUN	NN	Number=Sing	_	_	_	_
20	through	through	ADP	IN	_	_	_	_	_
21	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
22	erythroid	erythroid	ADJ	JJ	Degree=Pos	_	_	_	_
23	or	or	CCONJ	CC	_	_	_	_	_
24	granulocytic	granulocytic	ADJ	JJ	Degree=Pos	_	_	_	_
25	lineage	lineage	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
26	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1786
# text = Thereafter, PML is downmodulated in late granulocytic maturation, whereas it is sustainably expressed through the erythroid pathway.
1	Thereafter	thereafter	ADV	RB	_	_	_	_	SpaceAfter=No
2	,	,	PUNCT	,	_	_	_	_	_
3	PML	PML	PROPN	NNP	Number=Sing	_	_	_	_
4	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
5	downmodulated	downmodulate	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
6	in	in	ADP	IN	_	_	_	_	_
7	late	late	ADJ	JJ	Degree=Pos	_	_	_	_
8	granulocytic	granulocytic	ADJ	JJ	Degree=Pos	_	_	_	_
9	maturation	maturation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
10	,	,	PUNCT	,	_	_	_	_	_
11	whereas	whereas	SCONJ	IN	_	_	_	_	_
12	it	it	PRON	PRP	Case=Nom|Gender=Neut|Number=Sing|Person=3|PronType=Prs	_	_	_	_
13	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
14	sustainably	sustainably	ADV	RB	_	_	_	_	_
15	expressed	express	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
16	through	through	ADP	IN	_	_	_	_	_
17	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
18	erythroid	erythroid	ADJ	JJ	Degree=Pos	_	_	_	_
19	pathway	pathway	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
20	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1787
# text = In functional studies, PML expression was inhibited by addition of antisense oligomers targeting PML mRNA (alpha-PML).
1	In	in	ADP	IN	_	_	_	_	_
2	functional	functional	ADJ	JJ	Degree=Pos	_	_	_	_
3	studies	study	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	,	,	PUNCT	,	_	_	_	_	_
5	PML	PML	ADJ	JJ	Degree=Pos	_	_	_	_
6	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
7	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
8	inhibited	inhibit	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
9	by	by	ADP	IN	_	_	_	_	_
10	addition	addition	NOUN	NN	Number=Sing	_	_	_	_
11	of	of	ADP	IN	_	_	_	_	_
12	antisense	antisense	ADJ	JJ	Degree=Pos	_	_	_	_
13	oligomers	oligomer	NOUN	NNS	Number=Plur	_	_	_	_
14	targeting	target	VERB	VBG	VerbForm=Ger	_	_	_	_
15	PML	PML	PROPN	NNP	Number=Sing	_	_	_	_
16	mRNA	mRNA	PROPN	NNP	Number=Sing	_	_	_	_
17	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
18	alpha	alpha	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
19	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
20	PML	pMl	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
21	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
22	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1788
# text = Interestingly, early treatment (day 0 HPCs) with alpha-PML reduced the number of both erythroid and granulocytic colonies, whereas late treatment (day 5 culture) reduced erythroid, but not granulocytic, clonogenesis.
1	Interestingly	Interestingly	ADV	RB	_	_	_	_	SpaceAfter=No
2	,	,	PUNCT	,	_	_	_	_	_
3	early	early	ADJ	JJ	Degree=Pos	_	_	_	_
4	treatment	treatment	NOUN	NN	Number=Sing	_	_	_	_
5	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
6	day	day	NOUN	NN	Number=Sing	_	_	_	_
7	0	0	NUM	CD	NumType=Card	_	_	_	_
8	HPCs	HPC	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
9	)	)	PUNCT	-RRB-	_	_	_	_	_
10	with	with	ADP	IN	_	_	_	_	_
11	alpha	alpha	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
12	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
13	PML	PML	PROPN	NNP	Number=Sing	_	_	_	_
14	reduced	reduce	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
15	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
16	number	number	NOUN	NN	Number=Sing	_	_	_	_
17	of	of	ADP	IN	_	_	_	_	_
18	both	both	CCONJ	CC	_	_	_	_	_
19	erythroid	erythroid	ADJ	JJ	Degree=Pos	_	_	_	_
20	and	and	CCONJ	CC	_	_	_	_	_
21	granulocytic	granulocytic	ADJ	JJ	Degree=Pos	_	_	_	_
22	colonies	colony	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
23	,	,	PUNCT	,	_	_	_	_	_
24	whereas	whereas	SCONJ	IN	_	_	_	_	_
25	late	late	ADJ	JJ	Degree=Pos	_	_	_	_
26	treatment	treatment	NOUN	NN	Number=Sing	_	_	_	_
27	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
28	day	day	NOUN	NN	Number=Sing	_	_	_	_
29	5	5	NUM	CD	NumType=Card	_	_	_	_
30	culture	culture	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
31	)	)	PUNCT	-RRB-	_	_	_	_	_
32	reduced	reduce	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
33	erythroid	erythroid	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
34	,	,	PUNCT	,	_	_	_	_	_
35	but	but	CCONJ	CC	_	_	_	_	_
36	not	not	ADV	RB	_	_	_	_	_
37	granulocytic	granulocytic	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
38	,	,	PUNCT	,	_	_	_	_	_
39	clonogenesis	clonogenesis	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
40	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1789
# text = These findings suggest that PML is required for early hematopoiesis and erythroid, but not granulocytic maturation.
1	These	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
2	findings	finding	NOUN	NNS	Number=Plur	_	_	_	_
3	suggest	suggest	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
4	that	that	SCONJ	IN	_	_	_	_	_
5	PML	PML	PROPN	NNP	Number=Sing	_	_	_	_
6	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
7	required	require	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
8	for	for	ADP	IN	_	_	_	_	_
9	early	early	ADJ	JJ	Degree=Pos	_	_	_	_
10	hematopoiesis	hematopoiesis	NOUN	NN	Number=Sing	_	_	_	_
11	and	and	CCONJ	CC	_	_	_	_	_
12	erythroid	erythroid	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
13	,	,	PUNCT	,	_	_	_	_	_
14	but	but	CCONJ	CC	_	_	_	_	_
15	not	not	ADV	RB	_	_	_	_	_
16	granulocytic	granulocytic	ADJ	JJ	Degree=Pos	_	_	_	_
17	maturation	maturation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
18	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1790
# text = The pattern of PML expression in normal hematopoiesis mimics that of retinoblastoma pRb 105.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	pattern	pattern	NOUN	NN	Number=Sing	_	_	_	_
3	of	of	ADP	IN	_	_	_	_	_
4	PML	pMl	NOUN	NN	Number=Sing	_	_	_	_
5	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
6	in	in	ADP	IN	_	_	_	_	_
7	normal	normal	ADJ	JJ	Degree=Pos	_	_	_	_
8	hematopoiesis	hematopoiesis	NOUN	NN	Number=Sing	_	_	_	_
9	mimics	mimics	NOUN	NNS	Number=Plur	_	_	_	_
10	that	that	PRON	WDT	PronType=Rel	_	_	_	_
11	of	of	ADP	IN	_	_	_	_	_
12	retinoblastoma	retinoblastoma	NOUN	NN	Number=Sing	_	_	_	_
13	pRb	pRb	NOUN	NN	Number=Sing	_	_	_	_
14	105	105	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
15	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1791
# text = Combined treatment of HPCs with alpha-PML and alpha-Rb oligomers inhibited both PML and Rb protein expression and completely blocked erythroid colony development.
1	Combined	combine	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
2	treatment	treatment	NOUN	NN	Number=Sing	_	_	_	_
3	of	of	ADP	IN	_	_	_	_	_
4	HPCs	HPC	PROPN	NNPS	Number=Plur	_	_	_	_
5	with	with	ADP	IN	_	_	_	_	_
6	alpha	alpha	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
7	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
8	PML	PML	PROPN	NNP	Number=Sing	_	_	_	_
9	and	and	CCONJ	CC	_	_	_	_	_
10	alpha	alpha	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
11	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
12	Rb	Rb	PROPN	NNP	Number=Sing	_	_	_	_
13	oligomers	oligomer	NOUN	NNS	Number=Plur	_	_	_	_
14	inhibited	inhibit	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
15	both	both	CCONJ	CC	_	_	_	_	_
16	PML	PML	PROPN	NNP	Number=Sing	_	_	_	_
17	and	and	CCONJ	CC	_	_	_	_	_
18	Rb	Rb	PROPN	NNP	Number=Sing	_	_	_	_
19	protein	protein	NOUN	NN	Number=Sing	_	_	_	_
20	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
21	and	and	CCONJ	CC	_	_	_	_	_
22	completely	completely	ADV	RB	_	_	_	_	_
23	blocked	block	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
24	erythroid	erythroid	ADJ	JJ	Degree=Pos	_	_	_	_
25	colony	colony	NOUN	NN	Number=Sing	_	_	_	_
26	development	development	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
27	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1792
# text = Furthermore, PML and pRb 105 were co-immunoprecipitated in cellular lysates derived from erythroid precursors indicating that this functional interaction may have a biochemical basis.
1	Furthermore	furthermore	ADV	RB	_	_	_	_	SpaceAfter=No
2	,	,	PUNCT	,	_	_	_	_	_
3	PML	PML	PROPN	NNP	Number=Sing	_	_	_	_
4	and	and	CCONJ	CC	_	_	_	_	_
5	pRb	pRb	PROPN	NNP	Number=Sing	_	_	_	_
6	105	105	NUM	CD	NumType=Card	_	_	_	_
7	were	be	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
8	co-immunoprecipitated	co-immunoprecipitate	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
9	in	in	ADP	IN	_	_	_	_	_
10	cellular	cellular	ADJ	JJ	Degree=Pos	_	_	_	_
11	lysates	lysate	NOUN	NNS	Number=Plur	_	_	_	_
12	derived	derive	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
13	from	from	ADP	IN	_	_	_	_	_
14	erythroid	erythroid	ADJ	JJ	Degree=Pos	_	_	_	_
15	precursors	precursor	NOUN	NNS	Number=Plur	_	_	_	_
16	indicating	indicate	VERB	VBG	VerbForm=Ger	_	_	_	_
17	that	that	SCONJ	IN	_	_	_	_	_
18	this	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
19	functional	functional	ADJ	JJ	Degree=Pos	_	_	_	_
20	interaction	interaction	NOUN	NN	Number=Sing	_	_	_	_
21	may	may	AUX	MD	VerbForm=Fin	_	_	_	_
22	have	have	VERB	VB	VerbForm=Inf	_	_	_	_
23	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
24	biochemical	biochemical	ADJ	JJ	Degree=Pos	_	_	_	_
25	basis	basis	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
26	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1793
# text = These results suggest a key functional role of PML in early hematopoiesis and late erythropoiesis: the latter phenomenon may be related to the molecular and functional interaction of PML with pRb 105.
1	These	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
2	results	result	NOUN	NNS	Number=Plur	_	_	_	_
3	suggest	suggest	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
4	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
5	key	key	ADJ	JJ	Degree=Pos	_	_	_	_
6	functional	functional	ADJ	JJ	Degree=Pos	_	_	_	_
7	role	role	NOUN	NN	Number=Sing	_	_	_	_
8	of	of	ADP	IN	_	_	_	_	_
9	PML	pMl	NOUN	NN	Number=Sing	_	_	_	_
10	in	in	ADP	IN	_	_	_	_	_
11	early	early	ADJ	JJ	Degree=Pos	_	_	_	_
12	hematopoiesis	hematopoiesis	NOUN	NN	Number=Sing	_	_	_	_
13	and	and	CCONJ	CC	_	_	_	_	_
14	late	late	ADJ	JJ	Degree=Pos	_	_	_	_
15	erythropoiesis	erythropoiesis	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
16	:	:	PUNCT	:	_	_	_	_	_
17	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
18	latter	latter	ADJ	JJ	Degree=Pos	_	_	_	_
19	phenomenon	phenomenon	NOUN	NN	Number=Sing	_	_	_	_
20	may	may	AUX	MD	VerbForm=Fin	_	_	_	_
21	be	be	AUX	VB	VerbForm=Inf	_	_	_	_
22	related	related	ADJ	JJ	Degree=Pos	_	_	_	_
23	to	to	ADP	IN	_	_	_	_	_
24	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
25	molecular	molecular	ADJ	JJ	Degree=Pos	_	_	_	_
26	and	and	CCONJ	CC	_	_	_	_	_
27	functional	functional	ADJ	JJ	Degree=Pos	_	_	_	_
28	interaction	interaction	NOUN	NN	Number=Sing	_	_	_	_
29	of	of	ADP	IN	_	_	_	_	_
30	PML	pMl	NOUN	NN	Number=Sing	_	_	_	_
31	with	with	ADP	IN	_	_	_	_	_
32	pRb	pRb	NOUN	NN	Number=Sing	_	_	_	_
33	105	105	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
34	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 1794
# text = Document 00300346 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	00300346	00300346	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 1795
# text = Glucocorticoid receptors in anorexia nervosa and Cushing's disease.
1	Glucocorticoid	Glucocorticoid	ADJ	JJ	Degree=Pos	_	_	_	_
2	receptors	receptor	NOUN	NNS	Number=Plur	_	_	_	_
3	in	in	ADP	IN	_	_	_	_	_
4	anorexia	anorexia	PROPN	NNP	Number=Sing	_	_	_	_
5	nervosa	nervosa	PROPN	NNP	Number=Sing	_	_	_	_
6	and	and	CCONJ	CC	_	_	_	_	_
7	Cushing	Cushing	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
8	's	's	PART	POS	_	_	_	_	_
9	disease	disease	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
10	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 1796
# text = BACKGROUND: Patients with anorexia nervosa do not display cushingoid features in spite of elevated cortisol plasma levels.
1	BACKGROUND	background	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
2	:	:	PUNCT	:	_	_	_	_	_
3	Patients	patient	NOUN	NNS	Number=Plur	_	_	_	_
4	with	with	ADP	IN	_	_	_	_	_
5	anorexia	anorexia	NOUN	NN	Number=Sing	_	_	_	_
6	nervosa	nervosa	NOUN	NN	Number=Sing	_	_	_	_
7	do	do	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
8	not	not	PART	RB	_	_	_	_	_
9	display	display	VERB	VB	VerbForm=Inf	_	_	_	_
10	cushingoid	cushingoid	ADJ	JJ	Degree=Pos	_	_	_	_
11	features	feature	NOUN	NNS	Number=Plur	_	_	_	_
12	in	in	ADP	IN	_	_	_	_	_
13	spite	spite	NOUN	NN	Number=Sing	_	_	_	_
14	of	of	ADP	IN	_	_	_	_	_
15	elevated	elevate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
16	cortisol	cortisol	NOUN	NN	Number=Sing	_	_	_	_
17	plasma	plasma	NOUN	NN	Number=Sing	_	_	_	_
18	levels	level	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
19	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1797
# text = Whether a cortisol resistance or a reduced availability of the metabolic substrates necessary to develop the effect of glucocorticoids is responsible for this has not been established.
1	Whether	whether	SCONJ	IN	_	_	_	_	_
2	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
3	cortisol	cortisol	NOUN	NN	Number=Sing	_	_	_	_
4	resistance	resistance	NOUN	NN	Number=Sing	_	_	_	_
5	or	or	CCONJ	CC	_	_	_	_	_
6	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
7	reduced	reduce	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
8	availability	availability	NOUN	NN	Number=Sing	_	_	_	_
9	of	of	ADP	IN	_	_	_	_	_
10	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
11	metabolic	metabolic	NOUN	NN	Number=Sing	_	_	_	_
12	substrates	substrate	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
13	necessary	necessary	ADJ	JJ	Degree=Pos	_	_	_	_
14	to	to	PART	TO	_	_	_	_	_
15	develop	develop	VERB	VB	VerbForm=Inf	_	_	_	_
16	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
17	effect	effect	NOUN	NN	Number=Sing	_	_	_	_
18	of	of	ADP	IN	_	_	_	_	_
19	glucocorticoids	glucocorticoid	NOUN	NNS	Number=Plur	_	_	_	_
20	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
21	responsible	responsible	ADJ	JJ	Degree=Pos	_	_	_	_
22	for	for	ADP	IN	_	_	_	_	_
23	this	this	PRON	DT	Number=Sing|PronType=Dem	_	_	_	_
24	has	have	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
25	not	not	PART	RB	_	_	_	_	_
26	been	be	AUX	VBN	Tense=Past|VerbForm=Part	_	_	_	_
27	established	establish	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	SpaceAfter=No
28	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1798
# text = METHODS: Twenty-two patients with severe restrictive anorexia nervosa, 10 patients with active Cushing's disease, and 24 healthy volunteers without psychiatric disorders or mood alterations were investigated.
1	METHODS	method	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
2	:	:	PUNCT	:	_	_	_	_	_
3	Twenty	twenty	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
4	-	-	SYM	SYM	_	_	_	_	SpaceAfter=No
5	two	two	NUM	CD	NumType=Card	_	_	_	_
6	patients	patient	NOUN	NNS	Number=Plur	_	_	_	_
7	with	with	ADP	IN	_	_	_	_	_
8	severe	severe	ADJ	JJ	Degree=Pos	_	_	_	_
9	restrictive	restrictive	ADJ	JJ	Degree=Pos	_	_	_	_
10	anorexia	anorexia	NOUN	NN	Number=Sing	_	_	_	_
11	nervosa	nervosa	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
12	,	,	PUNCT	,	_	_	_	_	_
13	10	10	NUM	CD	NumType=Card	_	_	_	_
14	patients	patient	NOUN	NNS	Number=Plur	_	_	_	_
15	with	with	ADP	IN	_	_	_	_	_
16	active	active	ADJ	JJ	Degree=Pos	_	_	_	_
17	Cushing	Cushing	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
18	's	's	PART	POS	_	_	_	_	_
19	disease	disease	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
20	,	,	PUNCT	,	_	_	_	_	_
21	and	and	CCONJ	CC	_	_	_	_	_
22	24	24	NUM	CD	NumType=Card	_	_	_	_
23	healthy	healthy	ADJ	JJ	Degree=Pos	_	_	_	_
24	volunteers	volunteer	NOUN	NNS	Number=Plur	_	_	_	_
25	without	without	ADP	IN	_	_	_	_	_
26	psychiatric	psychiatric	ADJ	JJ	Degree=Pos	_	_	_	_
27	disorders	disorder	NOUN	NNS	Number=Plur	_	_	_	_
28	or	or	CCONJ	CC	_	_	_	_	_
29	mood	mood	NOUN	NN	Number=Sing	_	_	_	_
30	alterations	alteration	NOUN	NNS	Number=Plur	_	_	_	_
31	were	be	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
32	investigated	investigate	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	SpaceAfter=No
33	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1799
# text = Glucocorticoid receptor characteristics were examined on mononuclear leukocytes by measuring [3H]dexamethasone binding and the effect of dexamethasone on [3H]thymidine incorporation, which represents an index of DNA synthesis.
1	Glucocorticoid	Glucocorticoid	ADJ	JJ	Degree=Pos	_	_	_	_
2	receptor	receptor	NOUN	NN	Number=Sing	_	_	_	_
3	characteristics	characteristic	NOUN	NNS	Number=Plur	_	_	_	_
4	were	be	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
5	examined	examin	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
6	on	on	ADP	IN	_	_	_	_	_
7	mononuclear	mononuclear	ADJ	JJ	Degree=Pos	_	_	_	_
8	leukocytes	leukocyte	NOUN	NNS	Number=Plur	_	_	_	_
9	by	by	SCONJ	IN	_	_	_	_	_
10	measuring	measure	VERB	VBG	VerbForm=Ger	_	_	_	_
11	[	[	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
12	3	3	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
13	H]	H]	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
14	dexamethasone	dexamethasone	NOUN	NN	Number=Sing	_	_	_	_
15	binding	binding	VERB	VBG	VerbForm=Ger	_	_	_	_
16	and	and	CCONJ	CC	_	_	_	_	_
17	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
18	effect	effect	NOUN	NN	Number=Sing	_	_	_	_
19	of	of	ADP	IN	_	_	_	_	_
20	dexamethasone	dexamethasone	NOUN	NN	Number=Sing	_	_	_	_
21	on	on	ADP	IN	_	_	_	_	_
22	[	[	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
23	3	3	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
24	H	h	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
25	]	]	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
26	thymidine	thymidine	NOUN	NN	Number=Sing	_	_	_	_
27	incorporation	incorporation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
28	,	,	PUNCT	,	_	_	_	_	_
29	which	which	PRON	WDT	PronType=Rel	_	_	_	_
30	represents	represent	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
31	an	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
32	index	index	NOUN	NN	Number=Sing	_	_	_	_
33	of	of	ADP	IN	_	_	_	_	_
34	DNA	dna	NOUN	NN	Number=Sing	_	_	_	_
35	synthesis	synthesis	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
36	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1800
# text = RESULTS: The number of glucocorticoid receptors on mononuclear leukocytes (MNL) was comparable in patients with anorexia nervosa, patients with active Cushing's disease, and normal subjects (binding capacity 3.3 +/- 0.23 vs. 3.7 +/- 0.30 and 3.5 +/- 0.20 fmol/10(6) cells).
1	RESULTS	result	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
2	:	:	PUNCT	:	_	_	_	_	_
3	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
4	number	number	NOUN	NN	Number=Sing	_	_	_	_
5	of	of	ADP	IN	_	_	_	_	_
6	glucocorticoid	glucocorticoid	ADJ	JJ	Degree=Pos	_	_	_	_
7	receptors	receptor	NOUN	NNS	Number=Plur	_	_	_	_
8	on	on	ADP	IN	_	_	_	_	_
9	mononuclear	mononuclear	ADJ	JJ	Degree=Pos	_	_	_	_
10	leukocytes	leukocyte	NOUN	NNS	Number=Plur	_	_	_	_
11	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
12	MNL	MNL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
13	)	)	PUNCT	-RRB-	_	_	_	_	_
14	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
15	comparable	comparable	ADJ	JJ	Degree=Pos	_	_	_	_
16	in	in	ADP	IN	_	_	_	_	_
17	patients	patient	NOUN	NNS	Number=Plur	_	_	_	_
18	with	with	ADP	IN	_	_	_	_	_
19	anorexia	anorexia	NOUN	NN	Number=Sing	_	_	_	_
20	nervosa	nervosa	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
21	,	,	PUNCT	,	_	_	_	_	_
22	patients	patient	NOUN	NNS	Number=Plur	_	_	_	_
23	with	with	ADP	IN	_	_	_	_	_
24	active	active	ADJ	JJ	Degree=Pos	_	_	_	_
25	Cushing	Cushing	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
26	's	's	PART	POS	_	_	_	_	_
27	disease	disease	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
28	,	,	PUNCT	,	_	_	_	_	_
29	and	and	CCONJ	CC	_	_	_	_	_
30	normal	normal	ADJ	JJ	Degree=Pos	_	_	_	_
31	subjects	subject	NOUN	NNS	Number=Plur	_	_	_	_
32	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
33	binding	bind	VERB	VBG	VerbForm=Ger	_	_	_	_
34	capacity	capacity	NOUN	NN	Number=Sing	_	_	_	_
35	3.3	3.3	NUM	CD	NumType=Card	_	_	_	_
36	+/-	+/-	SYM	SYM	_	_	_	_	_
37	0.23	0.23	NUM	CD	NumType=Card	_	_	_	_
38	vs.	vs.	ADP	IN	_	_	_	_	_
39	3.7	3.7	NUM	CD	NumType=Card	_	_	_	_
40	+/-	+/-	SYM	SYM	_	_	_	_	_
41	0.30	0.30	NUM	CD	NumType=Card	_	_	_	_
42	and	and	CCONJ	CC	_	_	_	_	_
43	3.5	3.5	NUM	CD	NumType=Card	_	_	_	_
44	+/-	+/-	SYM	SYM	_	_	_	_	_
45	0.20	0.20	NUM	CD	NumType=Card	_	_	_	_
46	fmol/10	fmol/10	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
47	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
48	6	6	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
49	)	)	PUNCT	-RRB-	_	_	_	_	_
50	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
51	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
52	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1801
# text = Conversely, glucocorticoid receptor affinity was significantly decreased in anorexia nervosa as well as in Cushing's patients compared to control subjects (dissociation constant 4.0 +/- 0.31 and 4.1 +/- 0.34 vs. 2.9 +/- 0.29 nmol/L, p < .001) and inversely correlated with the levels of urinary free cortisol in both groups of patients.
1	Conversely	Conversely	ADV	RB	_	_	_	_	SpaceAfter=No
2	,	,	PUNCT	,	_	_	_	_	_
3	glucocorticoid	glucocorticoid	ADJ	JJ	Degree=Pos	_	_	_	_
4	receptor	receptor	NOUN	NN	Number=Sing	_	_	_	_
5	affinity	affinity	NOUN	NN	Number=Sing	_	_	_	_
6	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
7	significantly	significantly	ADV	RB	_	_	_	_	_
8	decreased	decrease	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
9	in	in	ADP	IN	_	_	_	_	_
10	anorexia	anorexia	NOUN	NN	Number=Sing	_	_	_	_
11	nervosa	nervosa	NOUN	NN	Number=Sing	_	_	_	_
12	as	as	ADV	RB	_	_	_	_	_
13	well	well	ADV	RB	Degree=Pos	_	_	_	_
14	as	as	ADP	IN	_	_	_	_	_
15	in	in	ADP	IN	_	_	_	_	_
16	Cushing	Cushing	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
17	's	's	PART	POS	_	_	_	_	_
18	patients	patient	NOUN	NNS	Number=Plur	_	_	_	_
19	compared	compare	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
20	to	to	PART	TO	_	_	_	_	_
21	control	control	VERB	VB	VerbForm=Inf	_	_	_	_
22	subjects	subject	NOUN	NNS	Number=Plur	_	_	_	_
23	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
24	dissociation	dissociation	NOUN	NN	Number=Sing	_	_	_	_
25	constant	constant	ADJ	JJ	Degree=Pos	_	_	_	_
26	4.0	4.0	NUM	CD	NumType=Card	_	_	_	_
27	+/-	+/-	SYM	SYM	_	_	_	_	_
28	0.31	0.31	NUM	CD	NumType=Card	_	_	_	_
29	and	and	CCONJ	CC	_	_	_	_	_
30	4.1	4.1	NUM	CD	NumType=Card	_	_	_	_
31	+/-	+/-	SYM	SYM	_	_	_	_	_
32	0.34	0.34	NUM	CD	NumType=Card	_	_	_	_
33	vs.	vs.	ADP	IN	_	_	_	_	_
34	2.9	2.9	NUM	CD	NumType=Card	_	_	_	_
35	+/-	+/-	SYM	SYM	_	_	_	_	_
36	0.29	0.29	NUM	CD	NumType=Card	_	_	_	_
37	nmol/L	nmol/l	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
38	,	,	PUNCT	,	_	_	_	_	_
39	p	p	NOUN	NN	Number=Sing	_	_	_	_
40	<	<	PUNCT	-LRB-	_	_	_	_	_
41	.001	.001	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
42	)	)	PUNCT	-RRB-	_	_	_	_	_
43	and	and	CCONJ	CC	_	_	_	_	_
44	inversely	inversely	ADV	RB	_	_	_	_	_
45	correlated	correlate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
46	with	with	ADP	IN	_	_	_	_	_
47	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
48	levels	level	NOUN	NNS	Number=Plur	_	_	_	_
49	of	of	ADP	IN	_	_	_	_	_
50	urinary	urinary	ADJ	JJ	Degree=Pos	_	_	_	_
51	free	free	ADJ	JJ	Degree=Pos	_	_	_	_
52	cortisol	cortisol	NOUN	NN	Number=Sing	_	_	_	_
53	in	in	ADP	IN	_	_	_	_	_
54	both	both	DET	DT	_	_	_	_	_
55	groups	group	NOUN	NNS	Number=Plur	_	_	_	_
56	of	of	ADP	IN	_	_	_	_	_
57	patients	patient	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
58	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1802
# text = Basal [3H]thymidine incorporation in MNL was significantly reduced in anorexia nervosa as well as in Cushing's patients compared to control subjects (p < .001) and was diminished by dexamethasone to an extent similar to control subjects in patients with anorexia nervosa, but significantly (p < .001) less in those with Cushing's disease.
1	Basal	Basal	PROPN	NNP	Number=Sing	_	_	_	_
2	[	[	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
3	3	3	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
4	H	h	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
5	]	]	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
6	thymidine	thymidine	NOUN	NN	Number=Sing	_	_	_	_
7	incorporation	incorporation	NOUN	NN	Number=Sing	_	_	_	_
8	in	in	ADP	IN	_	_	_	_	_
9	MNL	MNL	PROPN	NNP	Number=Sing	_	_	_	_
10	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
11	significantly	significantly	ADV	RB	_	_	_	_	_
12	reduced	reduce	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
13	in	in	ADP	IN	_	_	_	_	_
14	anorexia	anorexia	NOUN	NN	Number=Sing	_	_	_	_
15	nervosa	nervosa	NOUN	NN	Number=Sing	_	_	_	_
16	as	as	ADV	RB	_	_	_	_	_
17	well	well	ADV	RB	Degree=Pos	_	_	_	_
18	as	as	ADP	IN	_	_	_	_	_
19	in	in	ADP	IN	_	_	_	_	_
20	Cushing	Cushing	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
21	's	's	PART	POS	_	_	_	_	_
22	patients	patient	NOUN	NNS	Number=Plur	_	_	_	_
23	compared	compare	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
24	to	to	PART	TO	_	_	_	_	_
25	control	control	VERB	VB	VerbForm=Inf	_	_	_	_
26	subjects	subject	NOUN	NNS	Number=Plur	_	_	_	_
27	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
28	p	p	NOUN	NN	Number=Sing	_	_	_	_
29	<	<	PUNCT	-LRB-	_	_	_	_	_
30	.001	.001	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
31	)	)	PUNCT	-RRB-	_	_	_	_	_
32	and	and	CCONJ	CC	_	_	_	_	_
33	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
34	diminished	diminish	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
35	by	by	ADP	IN	_	_	_	_	_
36	dexamethasone	dexamethasone	NOUN	NN	Number=Sing	_	_	_	_
37	to	to	ADP	IN	_	_	_	_	_
38	an	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
39	extent	extent	NOUN	NN	Number=Sing	_	_	_	_
40	similar	similar	ADJ	JJ	Degree=Pos	_	_	_	_
41	to	to	PART	TO	_	_	_	_	_
42	control	control	VERB	VB	VerbForm=Inf	_	_	_	_
43	subjects	subject	NOUN	NNS	Number=Plur	_	_	_	_
44	in	in	ADP	IN	_	_	_	_	_
45	patients	patient	NOUN	NNS	Number=Plur	_	_	_	_
46	with	with	ADP	IN	_	_	_	_	_
47	anorexia	anorexia	NOUN	NN	Number=Sing	_	_	_	_
48	nervosa	nervosa	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
49	,	,	PUNCT	,	_	_	_	_	_
50	but	but	CCONJ	CC	_	_	_	_	_
51	significantly	significantly	ADV	RB	_	_	_	_	_
52	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
53	p	p	NOUN	NN	Number=Sing	_	_	_	_
54	<	<	PUNCT	-LRB-	_	_	_	_	_
55	.001	.001	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
56	)	)	PUNCT	-RRB-	_	_	_	_	_
57	less	less	ADJ	JJR	Degree=Cmp	_	_	_	_
58	in	in	ADP	IN	_	_	_	_	_
59	those	those	PRON	DT	Number=Plur|PronType=Dem	_	_	_	_
60	with	with	ADP	IN	_	_	_	_	_
61	Cushing	Cushing	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
62	's	's	PART	POS	_	_	_	_	_
63	disease	disease	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
64	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1803
# text = In patients with anorexia nervosa, the incorporation of [3H]thymidine into the MNL was inversely correlated with urinary free cortisol levels.
1	In	in	ADP	IN	_	_	_	_	_
2	patients	patient	NOUN	NN	Number=Sing	_	_	_	_
3	with	with	ADP	IN	_	_	_	_	_
4	anorexia	anorexia	NOUN	NN	Number=Sing	_	_	_	_
5	nervosa	nervosa	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
6	,	,	PUNCT	,	_	_	_	_	_
7	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
8	incorporation	incorporation	NOUN	NN	Number=Sing	_	_	_	_
9	of	of	ADP	IN	_	_	_	_	_
10	[	[	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
11	3H]	3H]	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
12	thymidine	thymidine	NOUN	NN	Number=Sing	_	_	_	_
13	into	into	ADP	IN	_	_	_	_	_
14	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
15	MNL	Mnl	PROPN	NNP	Number=Sing	_	_	_	_
16	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
17	inversely	inversely	ADV	RB	_	_	_	_	_
18	correlated	correlate	ADJ	JJ	Degree=Pos	_	_	_	_
19	with	with	ADP	IN	_	_	_	_	_
20	urinary	urinary	ADJ	JJ	Degree=Pos	_	_	_	_
21	free	free	ADJ	JJ	Degree=Pos	_	_	_	_
22	cortisol	cortisol	NOUN	NN	Number=Sing	_	_	_	_
23	levels	level	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
24	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1804
# text = CONCLUSIONS:
1	CONCLUSIONS	conclusion	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
2	:	:	PUNCT	:	_	_	_	_	_

# sent_id = 1805
# text = These data indicate that the lack of cushingoid features in patients with anorexia nervosa is not ascribable to a reduced sensitivity to glucocorticoids but is more likely due to the paucity of metabolic substrates.
1	These	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
2	data	data	NOUN	NN	Number=Sing	_	_	_	_
3	indicate	indicate	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
4	that	that	SCONJ	IN	_	_	_	_	_
5	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
6	lack	lack	NOUN	NN	Number=Sing	_	_	_	_
7	of	of	ADP	IN	_	_	_	_	_
8	cushingoid	cushingoid	ADJ	JJ	Degree=Pos	_	_	_	_
9	features	feature	NOUN	NNS	Number=Plur	_	_	_	_
10	in	in	ADP	IN	_	_	_	_	_
11	patients	patient	NOUN	NNS	Number=Plur	_	_	_	_
12	with	with	ADP	IN	_	_	_	_	_
13	anorexia	anorexia	NOUN	NN	Number=Sing	_	_	_	_
14	nervosa	nervosa	NOUN	NN	Number=Sing	_	_	_	_
15	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
16	not	not	PART	RB	_	_	_	_	_
17	ascribable	ascribable	ADJ	JJ	Degree=Pos	_	_	_	_
18	to	to	ADP	IN	_	_	_	_	_
19	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
20	reduced	reduce	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
21	sensitivity	sensitivity	NOUN	NN	Number=Sing	_	_	_	_
22	to	to	ADP	IN	_	_	_	_	_
23	glucocorticoids	glucocorticoid	NOUN	NNS	Number=Plur	_	_	_	_
24	but	but	CCONJ	CC	_	_	_	_	_
25	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
26	more	more	ADV	RBR	_	_	_	_	_
27	likely	likely	ADJ	JJ	Degree=Pos	_	_	_	_
28	due	due	ADP	IN	_	_	_	_	_
29	to	to	ADP	IN	_	_	_	_	_
30	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
31	paucity	paucity	NOUN	NN	Number=Sing	_	_	_	_
32	of	of	ADP	IN	_	_	_	_	_
33	metabolic	metabolic	ADJ	JJ	Degree=Pos	_	_	_	_
34	substrates	substrate	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
35	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 1806
# text = Document 00300349 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	00300349	00300349	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 1807
# text = Genes that regulate interleukin-4 expression in T cells.
1	Genes	gene	NOUN	NNS	Number=Plur	_	_	_	_
2	that	that	PRON	WDT	PronType=Rel	_	_	_	_
3	regulate	regulate	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
4	interleukin	interleukin	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
5	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
6	4	4	NUM	CD	NumType=Card	_	_	_	_
7	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
8	in	in	ADP	IN	_	_	_	_	_
9	T	t	PROPN	NNP	Number=Sing	_	_	_	_
10	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
11	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 1808
# text = Interleukin-4 is an immunomodulatory cytokine which plays a central role in the regulation of allergic and atopic immune responses.
1	Interleukin	Interleukin	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
2	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
3	4	4	NUM	CD	NumType=Card	_	_	_	_
4	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
5	an	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
6	immunomodulatory	immunomodulatory	ADJ	JJ	Degree=Pos	_	_	_	_
7	cytokine	cytokine	NOUN	NN	Number=Sing	_	_	_	_
8	which	which	PRON	WDT	PronType=Rel	_	_	_	_
9	plays	play	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
10	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
11	central	central	ADJ	JJ	Degree=Pos	_	_	_	_
12	role	role	NOUN	NN	Number=Sing	_	_	_	_
13	in	in	ADP	IN	_	_	_	_	_
14	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
15	regulation	regulation	NOUN	NN	Number=Sing	_	_	_	_
16	of	of	ADP	IN	_	_	_	_	_
17	allergic	allergic	ADJ	JJ	Degree=Pos	_	_	_	_
18	and	and	CCONJ	CC	_	_	_	_	_
19	atopic	atopic	ADJ	JJ	Degree=Pos	_	_	_	_
20	immune	immune	ADJ	JJ	Degree=Pos	_	_	_	_
21	responses	response	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
22	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1809
# text = Significant progress has been made in gaining a detailed understanding of the transcriptional regulation of the interleukin-4 gene.
1	Significant	significant	ADJ	JJ	Degree=Pos	_	_	_	_
2	progress	progress	NOUN	NN	Number=Sing	_	_	_	_
3	has	have	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
4	been	be	AUX	VBN	Tense=Past|VerbForm=Part	_	_	_	_
5	made	make	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
6	in	in	SCONJ	IN	_	_	_	_	_
7	gaining	gain	VERB	VBG	VerbForm=Ger	_	_	_	_
8	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
9	detailed	detailed	ADJ	JJ	Degree=Pos	_	_	_	_
10	understanding	understanding	NOUN	NN	Number=Sing	_	_	_	_
11	of	of	ADP	IN	_	_	_	_	_
12	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
13	transcriptional	transcriptional	ADJ	JJ	Degree=Pos	_	_	_	_
14	regulation	regulation	NOUN	NN	Number=Sing	_	_	_	_
15	of	of	ADP	IN	_	_	_	_	_
16	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
17	interleukin	interleukin	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
18	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
19	4	4	NUM	CD	NumType=Card	_	_	_	_
20	gene	gene	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
21	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1810
# text = The recent identification and characterization of several key transcription factors has helped to elucidate the molecular mechanisms of T helper cell cytokine gene expression.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	recent	recent	ADJ	JJ	Degree=Pos	_	_	_	_
3	identification	identification	NOUN	NN	Number=Sing	_	_	_	_
4	and	and	CCONJ	CC	_	_	_	_	_
5	characterization	characterization	NOUN	NN	Number=Sing	_	_	_	_
6	of	of	ADP	IN	_	_	_	_	_
7	several	several	ADJ	JJ	Degree=Pos	_	_	_	_
8	key	key	ADJ	JJ	Degree=Pos	_	_	_	_
9	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
10	factors	factor	NOUN	NNS	Number=Plur	_	_	_	_
11	has	have	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
12	helped	help	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
13	to	to	PART	TO	_	_	_	_	_
14	elucidate	elucidate	VERB	VB	VerbForm=Inf	_	_	_	_
15	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
16	molecular	molecular	ADJ	JJ	Degree=Pos	_	_	_	_
17	mechanisms	mechanism	NOUN	NNS	Number=Plur	_	_	_	_
18	of	of	ADP	IN	_	_	_	_	_
19	T	t	PROPN	NNP	Number=Sing	_	_	_	_
20	helper	helper	NOUN	NN	Number=Sing	_	_	_	_
21	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
22	cytokine	cytokine	NOUN	NN	Number=Sing	_	_	_	_
23	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
24	expression	expression	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
25	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 1811
# text = Document 00300354 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	00300354	00300354	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 1812
# text = Extracellular signal-regulated protein kinase (ERK)-dependent and ERK-independent pathways target STAT3 on serine-727 in human neutrophils stimulated by chemotactic factors and cytokines.
1	Extracellular	Extracelular	ADJ	JJ	Degree=Pos	_	_	_	_
2	signal	signal	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
3	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
4	regulated	regulate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
5	protein	protein	NOUN	NN	Number=Sing	_	_	_	_
6	kinase	kinase	NOUN	NN	Number=Sing	_	_	_	_
7	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
8	ERK	ERK	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
9	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
10	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
11	dependent	dependent	ADJ	JJ	Degree=Pos	_	_	_	_
12	and	and	CCONJ	CC	_	_	_	_	_
13	ERK	ERK	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
14	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
15	independent	independent	ADJ	JJ	Degree=Pos	_	_	_	_
16	pathways	pathway	NOUN	NNS	Number=Plur	_	_	_	_
17	target	target	NOUN	NN	Number=Sing	_	_	_	_
18	STAT3	STAT3	NOUN	NN	Number=Sing	_	_	_	_
19	on	on	ADP	IN	_	_	_	_	_
20	serine	serine	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
21	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
22	727	727	NUM	CD	NumType=Card	_	_	_	_
23	in	in	ADP	IN	_	_	_	_	_
24	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
25	neutrophils	neutrophil	NOUN	NNS	Number=Plur	_	_	_	_
26	stimulated	stimulate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
27	by	by	ADP	IN	_	_	_	_	_
28	chemotactic	chemotactic	ADJ	JJ	Degree=Pos	_	_	_	_
29	factors	factor	NOUN	NNS	Number=Plur	_	_	_	_
30	and	and	CCONJ	CC	_	_	_	_	_
31	cytokines	cytokine	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
32	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 1813
# text = STAT3 (signal transducer and activator of transcription 3) is a latent transcription factor that is activated by tyrosine phosphorylation (Tyr-705) in cells stimulated with cytokines or growth factors.
1	STAT3	STAT3	NOUN	NN	Number=Sing	_	_	_	_
2	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
3	signal	signal	NOUN	NN	Number=Sing	_	_	_	_
4	transducer	transducer	NOUN	NN	Number=Sing	_	_	_	_
5	and	and	CCONJ	CC	_	_	_	_	_
6	activator	activator	NOUN	NN	Number=Sing	_	_	_	_
7	of	of	ADP	IN	_	_	_	_	_
8	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
9	3	3	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
10	)	)	PUNCT	-RRB-	_	_	_	_	_
11	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
12	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
13	latent	latent	ADJ	JJ	Degree=Pos	_	_	_	_
14	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
15	factor	factor	NOUN	NN	Number=Sing	_	_	_	_
16	that	that	PRON	WDT	PronType=Rel	_	_	_	_
17	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
18	activated	activate	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
19	by	by	ADP	IN	_	_	_	_	_
20	tyrosine	tyrosine	NOUN	NN	Number=Sing	_	_	_	_
21	phosphorylation	phosphorylation	NOUN	NN	Number=Sing	_	_	_	_
22	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
23	Tyr	Tyr	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
24	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
25	705	705	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
26	)	)	PUNCT	-RRB-	_	_	_	_	_
27	in	in	ADP	IN	_	_	_	_	_
28	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
29	stimulated	stimulate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
30	with	with	ADP	IN	_	_	_	_	_
31	cytokines	cytokine	NOUN	NNS	Number=Plur	_	_	_	_
32	or	or	CCONJ	CC	_	_	_	_	_
33	growth	growth	NOUN	NN	Number=Sing	_	_	_	_
34	factors	factor	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
35	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1814
# text = Recent studies suggest that one or more cytoplasmic serine kinases also phosphorylate STAT3 and are necessary for maximal gene activation.
1	Recent	recent	ADJ	JJ	Degree=Pos	_	_	_	_
2	studies	study	NOUN	NNS	Number=Plur	_	_	_	_
3	suggest	suggest	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
4	that	that	SCONJ	IN	_	_	_	_	_
5	one	one	NUM	CD	NumType=Card	_	_	_	_
6	or	or	CCONJ	CC	_	_	_	_	_
7	more	more	ADJ	JJR	Degree=Cmp	_	_	_	_
8	cytoplasmic	cytoplasmic	ADJ	JJ	Degree=Pos	_	_	_	_
9	serine	serine	NOUN	NN	Number=Sing	_	_	_	_
10	kinases	kinase	NOUN	NNS	Number=Plur	_	_	_	_
11	also	also	ADV	RB	_	_	_	_	_
12	phosphorylate	phosphorylate	ADJ	JJ	Degree=Pos	_	_	_	_
13	STAT3	STAT3	NOUN	NN	Number=Sing	_	_	_	_
14	and	and	CCONJ	CC	_	_	_	_	_
15	are	be	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
16	necessary	necessary	ADJ	JJ	Degree=Pos	_	_	_	_
17	for	for	ADP	IN	_	_	_	_	_
18	maximal	maximal	ADJ	JJ	Degree=Pos	_	_	_	_
19	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
20	activation	activation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
21	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1815
# text = Here we demonstrate, with a site-specific antibody, that STAT3 is phosphorylated on Ser-727 in human neutrophils stimulated with chemotactic factors (N-formyl-methionyl-leucyl-phenylalanine and complement C5a), cytokines [granulocyte/macrophage colony-stimulating factor (GM-CSF) and granulocyte colony-stimulating factor (G-CSF)], or a protein kinase C activator (PMA).
1	Here	here	ADV	RB	PronType=Dem	_	_	_	_
2	we	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
3	demonstrate	demonstrate	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	SpaceAfter=No
4	,	,	PUNCT	,	_	_	_	_	_
5	with	with	ADP	IN	_	_	_	_	_
6	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
7	site	site	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
8	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
9	specific	specific	ADJ	JJ	Degree=Pos	_	_	_	_
10	antibody	antibody	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
11	,	,	PUNCT	,	_	_	_	_	_
12	that	that	SCONJ	IN	_	_	_	_	_
13	STAT3	STAT3	NOUN	NN	Number=Sing	_	_	_	_
14	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
15	phosphorylated	phosphorylate	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
16	on	on	ADP	IN	_	_	_	_	_
17	Ser-727	Ser-727	NUM	CD	NumType=Card	_	_	_	_
18	in	in	ADP	IN	_	_	_	_	_
19	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
20	neutrophils	neutrophil	NOUN	NNS	Number=Plur	_	_	_	_
21	stimulated	stimulate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
22	with	with	ADP	IN	_	_	_	_	_
23	chemotactic	chemotactic	ADJ	JJ	Degree=Pos	_	_	_	_
24	factors	factor	NOUN	NNS	Number=Plur	_	_	_	_
25	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
26	N-formyl-methionyl-leucyl-phenylalanine	N-formyl-methionyl-leucyl-phenylalanine	ADJ	JJ	Degree=Pos	_	_	_	_
27	and	and	CCONJ	CC	_	_	_	_	_
28	complement	complement	ADJ	JJ	Degree=Pos	_	_	_	_
29	C5a	C5a	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
30	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
31	,	,	PUNCT	,	_	_	_	_	_
32	cytokines	cytokine	NOUN	NNS	Number=Plur	_	_	_	_
33	[	[	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
34	granulocyte	granulocyte	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
35	/	/	PUNCT	,	_	_	_	_	SpaceAfter=No
36	macrophage	macrophage	NOUN	NN	Number=Sing	_	_	_	_
37	colony	colony	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
38	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
39	stimulating	stimulating	VERB	VBG	VerbForm=Ger	_	_	_	_
40	factor	factor	NOUN	NN	Number=Sing	_	_	_	_
41	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
42	GM	GM	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
43	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
44	CSF	CSF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
45	)	)	PUNCT	-RRB-	_	_	_	_	_
46	and	and	CCONJ	CC	_	_	_	_	_
47	granulocyte	granulocyte	NOUN	NN	Number=Sing	_	_	_	_
48	colony	colony	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
49	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
50	stimulating	stimulating	VERB	VBG	VerbForm=Ger	_	_	_	_
51	factor	factor	NOUN	NN	Number=Sing	_	_	_	_
52	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
53	G-	g-	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
54	CSF	Csf	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
55	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
56	]	]	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
57	,	,	PUNCT	,	_	_	_	_	_
58	or	or	CCONJ	CC	_	_	_	_	_
59	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
60	protein	protein	NOUN	NN	Number=Sing	_	_	_	_
61	kinase	kinase	NOUN	NN	Number=Sing	_	_	_	_
62	C	c	NOUN	NN	Number=Sing	_	_	_	_
63	activator	activator	NOUN	NN	Number=Sing	_	_	_	_
64	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
65	PMA	PMA	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
66	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
67	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1816
# text = (2-Amino-3'-methoxyphenyl)oxanaphthalen-4-one (PD 98059), an inhibitor of extracellular signal-regulated protein kinase (ERK) activation, blocked the serine phosphorylation of STAT3 induced by chemotactic factors or PMA.
1	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
2	2	2	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
3	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
4	Amino	Amino	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
5	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
6	3	3	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
7	'	'	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
8	-	-	PUNCT	:	_	_	_	_	SpaceAfter=No
9	methoxyphenyl	methoxyphenyl	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
10	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
11	oxanaphthalen	oxanaphthal	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
12	-	-	SYM	SYM	_	_	_	_	SpaceAfter=No
13	4	4	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
14	-	-	SYM	SYM	_	_	_	_	SpaceAfter=No
15	one	one	NUM	CD	NumType=Card	_	_	_	_
16	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
17	PD	P	NOUN	NN	Number=Sing	_	_	_	_
18	98059	98059	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
19	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
20	,	,	PUNCT	,	_	_	_	_	_
21	an	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
22	inhibitor	inhibitor	NOUN	NN	Number=Sing	_	_	_	_
23	of	of	ADP	IN	_	_	_	_	_
24	extracellular	extracellular	ADJ	JJ	Degree=Pos	_	_	_	_
25	signal	signal	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
26	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
27	regulated	regulate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
28	protein	protein	NOUN	NN	Number=Sing	_	_	_	_
29	kinase	kinase	NOUN	NN	Number=Sing	_	_	_	_
30	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
31	ERK	ERK	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
32	)	)	PUNCT	-RRB-	_	_	_	_	_
33	activation	activation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
34	,	,	PUNCT	,	_	_	_	_	_
35	blocked	block	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
36	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
37	serine	serine	NOUN	NN	Number=Sing	_	_	_	_
38	phosphorylation	phosphorylation	NOUN	NN	Number=Sing	_	_	_	_
39	of	of	ADP	IN	_	_	_	_	_
40	STAT3	STAT3	NUM	CD	NumType=Card	_	_	_	_
41	induced	induce	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
42	by	by	ADP	IN	_	_	_	_	_
43	chemotactic	chemotactic	ADJ	JJ	Degree=Pos	_	_	_	_
44	factors	factor	NOUN	NNS	Number=Plur	_	_	_	_
45	or	or	CCONJ	CC	_	_	_	_	_
46	PMA	PMA	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
47	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1817
# text = The drug was less effective on cytokines: it virtually abolished the response to GM-CSF that occurred 5 min after stimulation but only partly decreased those at 15-30 min and did not appreciably alter responses to G-CSF regardless of incubation time.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	drug	drug	NOUN	NN	Number=Sing	_	_	_	_
3	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
4	less	less	ADV	RBR	Degree=Cmp	_	_	_	_
5	effective	effective	ADJ	JJ	Degree=Pos	_	_	_	_
6	on	on	ADP	IN	_	_	_	_	_
7	cytokines	cytokine	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
8	:	:	PUNCT	:	_	_	_	_	_
9	it	it	PRON	PRP	Case=Nom|Gender=Neut|Number=Sing|Person=3|PronType=Prs	_	_	_	_
10	virtually	virtually	ADV	RB	_	_	_	_	_
11	abolished	abolish	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
12	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
13	response	response	NOUN	NN	Number=Sing	_	_	_	_
14	to	to	ADP	IN	_	_	_	_	_
15	GM	GM	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
16	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
17	CSF	CSF	PROPN	NNP	Number=Sing	_	_	_	_
18	that	that	PRON	WDT	PronType=Rel	_	_	_	_
19	occurred	occur	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
20	5	5	NUM	CD	NumType=Card	_	_	_	_
21	min	min	NOUN	NNS	Number=Plur	_	_	_	_
22	after	after	ADP	IN	_	_	_	_	_
23	stimulation	stimulation	NOUN	NN	Number=Sing	_	_	_	_
24	but	but	CCONJ	CC	_	_	_	_	_
25	only	only	ADV	RB	_	_	_	_	_
26	partly	partly	ADV	RB	_	_	_	_	_
27	decreased	decrease	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
28	those	those	PRON	DT	Number=Plur|PronType=Dem	_	_	_	_
29	at	at	ADP	IN	_	_	_	_	_
30	15	15	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
31	-	-	SYM	SYM	_	_	_	_	SpaceAfter=No
32	30	30	NUM	CD	NumType=Card	_	_	_	_
33	min	min	NOUN	NNS	Number=Plur	_	_	_	_
34	and	and	CCONJ	CC	_	_	_	_	_
35	did	do	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
36	not	not	PART	RB	_	_	_	_	_
37	appreciably	appreciably	ADV	RB	_	_	_	_	_
38	alter	alter	VERB	VB	VerbForm=Inf	_	_	_	_
39	responses	response	NOUN	NNS	Number=Plur	_	_	_	_
40	to	to	ADP	IN	_	_	_	_	_
41	G-	G-	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
42	CSF	CSF	PROPN	NNP	Number=Sing	_	_	_	_
43	regardless	regardless	ADV	RB	_	_	_	_	_
44	of	of	ADP	IN	_	_	_	_	_
45	incubation	incubation	NOUN	NN	Number=Sing	_	_	_	_
46	time	time	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
47	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1818
# text = 1-(5-Isoquinolinylsulphonyl)-2-methylpiperazine dihydrochloride
1	1	1	X	LS	_	_	_	_	SpaceAfter=No
2	-(	-(	PUNCT	.	_	_	_	_	SpaceAfter=No
3	5	5	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
4	-Isoquinolinylsulphonyl	-Isoquinolinylsulphonyl	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
5	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
6	-	-	PUNCT	:	_	_	_	_	SpaceAfter=No
7	2	2	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
8	-methylpiperazine	-methylpiperazine	NOUN	NN	Number=Sing	_	_	_	_
9	dihydrochloride	dihydrochloride	NOUN	NN	Number=Sing	_	_	_	_

# sent_id = 1819
# text = (H7), an inhibitor of a putative STAT3 serine kinase, and 4-(4-fluorophenyl)-2-(4-methylsulphinylphenyl)-5-(4-pyridyl) 1H-imidazole (SB 203580), an inhibitor of p38 mitogen-activated protein (MAP) kinase, did not dampen any of these serine phosphorylation responses.
1	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
2	H7	H7	X	LS	_	_	_	_	SpaceAfter=No
3	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
4	,	,	PUNCT	,	_	_	_	_	_
5	an	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
6	inhibitor	inhibitor	NOUN	NN	Number=Sing	_	_	_	_
7	of	of	ADP	IN	_	_	_	_	_
8	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
9	putative	putative	ADJ	JJ	Degree=Pos	_	_	_	_
10	STAT3	STAT3	NOUN	NN	Number=Sing	_	_	_	_
11	serine	serine	NOUN	NN	Number=Sing	_	_	_	_
12	kinase	kinase	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
13	,	,	PUNCT	,	_	_	_	_	_
14	and	and	CCONJ	CC	_	_	_	_	_
15	4	4	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
16	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
17	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
18	4	4	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
19	-fluorophenyl	-fluorophenyl	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
20	)-	)-	PUNCT	.	_	_	_	_	SpaceAfter=No
21	2-(	2-(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
22	4-methylsulphinylphenyl)-	4-methylsulphinylphenyl)-	SYM	NFP	_	_	_	_	SpaceAfter=No
23	5	5	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
24	-(	-(	PUNCT	.	_	_	_	_	SpaceAfter=No
25	4	4	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
26	-pyridyl	-pyridyl	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
27	)	)	PUNCT	-RRB-	_	_	_	_	_
28	1H	1h	ADJ	JJ	Degree=Pos|NumType=Ord	_	_	_	SpaceAfter=No
29	-imidazole	-imidazole	NOUN	NN	Number=Sing	_	_	_	_
30	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
31	SB	Sb	NOUN	NN	Number=Sing	_	_	_	_
32	203580	203580	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
33	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
34	,	,	PUNCT	,	_	_	_	_	_
35	an	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
36	inhibitor	inhibitor	NOUN	NN	Number=Sing	_	_	_	_
37	of	of	ADP	IN	_	_	_	_	_
38	p38	p38	NUM	CD	NumType=Card	_	_	_	_
39	mitogen	mitogen	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
40	-	-	PUNCT	:	_	_	_	_	SpaceAfter=No
41	activated	activated	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
42	protein	protein	NOUN	NN	Number=Sing	_	_	_	_
43	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
44	MAP	map	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
45	)	)	PUNCT	-RRB-	_	_	_	_	_
46	kinase	kinase	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
47	,	,	PUNCT	,	_	_	_	_	_
48	did	do	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
49	not	not	PART	RB	_	_	_	_	_
50	dampen	dampen	VERB	VB	VerbForm=Inf	_	_	_	_
51	any	any	DET	DT	_	_	_	_	_
52	of	of	ADP	IN	_	_	_	_	_
53	these	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
54	serine	serine	NOUN	NN	Number=Sing	_	_	_	_
55	phosphorylation	phosphorylation	NOUN	NN	Number=Sing	_	_	_	_
56	responses	response	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
57	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1820
# text = We propose that neutrophils use both ERK-dependent and ERK-independent pathways to phosphorylate Ser-727 on STAT3.
1	We	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
2	propose	propose	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
3	that	that	SCONJ	IN	_	_	_	_	_
4	neutrophils	neutrophil	NOUN	NNS	Number=Plur	_	_	_	_
5	use	use	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
6	both	both	CCONJ	CC	_	_	_	_	_
7	ERK	ERK	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
8	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
9	dependent	dependent	ADJ	JJ	Degree=Pos	_	_	_	_
10	and	and	CCONJ	CC	_	_	_	_	_
11	ERK	ERK	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
12	-independent	-independent	ADJ	JJ	Degree=Pos	_	_	_	_
13	pathways	pathway	NOUN	NNS	Number=Plur	_	_	_	_
14	to	to	PART	TO	_	_	_	_	_
15	phosphorylate	phosphorylate	VERB	VB	VerbForm=Inf	_	_	_	_
16	Ser-727	Ser-727	NUM	CD	NumType=Card	_	_	_	_
17	on	on	ADP	IN	_	_	_	_	_
18	STAT3	STAT3	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
19	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1821
# text = The former pathway is recruited by all ERK-activating stimuli, whereas the latter pathway uses an undefined serine kinase and is recruited selectively by cytokines.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	former	former	ADJ	JJ	Degree=Pos	_	_	_	_
3	pathway	pathway	NOUN	NN	Number=Sing	_	_	_	_
4	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
5	recruited	recruit	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
6	by	by	ADP	IN	_	_	_	_	_
7	all	all	DET	DT	_	_	_	_	_
8	ERK-	ERK-	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
9	activating	activat	VERB	VBG	VerbForm=Ger	_	_	_	_
10	stimuli	stimuli	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
11	,	,	PUNCT	,	_	_	_	_	_
12	whereas	whereas	SCONJ	IN	_	_	_	_	_
13	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
14	latter	latter	ADJ	JJ	Degree=Pos	_	_	_	_
15	pathway	pathway	NOUN	NN	Number=Sing	_	_	_	_
16	uses	use	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
17	an	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
18	undefined	undefin	ADJ	JJ	Degree=Pos	_	_	_	_
19	serine	serine	NOUN	NN	Number=Sing	_	_	_	_
20	kinase	kinase	NOUN	NN	Number=Sing	_	_	_	_
21	and	and	CCONJ	CC	_	_	_	_	_
22	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
23	recruited	recruit	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
24	selectively	selectively	ADV	RB	_	_	_	_	_
25	by	by	ADP	IN	_	_	_	_	_
26	cytokines	cytokine	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
27	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 1822
# text = Document 00300356 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	00300356	00300356	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 1823
# text = Effects of IL-10 and IL-4 on LPS-induced transcription factors (AP-1, NF-IL6 and NF-kappa B) which are involved in IL-6 regulation.
1	Effects	Effects	PROPN	NNPS	Number=Plur	_	_	_	_
2	of	of	ADP	IN	_	_	_	_	_
3	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
4	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
5	10	10	NUM	CD	NumType=Card	_	_	_	_
6	and	and	CCONJ	CC	_	_	_	_	_
7	IL	Il	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
8	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
9	4	4	NUM	CD	NumType=Card	_	_	_	_
10	on	on	ADP	IN	_	_	_	_	_
11	LPS	LPS	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
12	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
13	induced	induce	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
14	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
15	factors	factor	NOUN	NNS	Number=Plur	_	_	_	_
16	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
17	AP	ap	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
18	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
19	1	1	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
20	,	,	PUNCT	,	_	_	_	_	_
21	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
22	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
23	IL6	Il6	PROPN	NNP	Number=Sing	_	_	_	_
24	and	and	CCONJ	CC	_	_	_	_	_
25	NF	Nf	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
26	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
27	kappa	kappa	PROPN	NNP	Number=Sing	_	_	_	_
28	B	b	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
29	)	)	PUNCT	-RRB-	_	_	_	_	_
30	which	which	PRON	WDT	PronType=Rel	_	_	_	_
31	are	be	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
32	involved	involved	ADJ	JJ	Degree=Pos	_	_	_	_
33	in	in	ADP	IN	_	_	_	_	_
34	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
35	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
36	6	6	NUM	CD	NumType=Card	_	_	_	_
37	regulation	regulation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
38	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 1824
# text = Interleukin-10 (IL-10), like IL-4, is known to inhibit cytokine expression in activated human monocytes.
1	Interleukin	Interleukin	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
2	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
3	10	10	NUM	CD	NumType=Card	_	_	_	_
4	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
5	IL	Il	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
6	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
7	10	10	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
8	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
9	,	,	PUNCT	,	_	_	_	_	_
10	like	like	ADP	IN	_	_	_	_	_
11	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
12	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
13	4	4	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
14	,	,	PUNCT	,	_	_	_	_	_
15	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
16	known	know	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
17	to	to	PART	TO	_	_	_	_	_
18	inhibit	inhibit	VERB	VB	VerbForm=Inf	_	_	_	_
19	cytokine	cytokine	NOUN	NN	Number=Sing	_	_	_	_
20	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
21	in	in	ADP	IN	_	_	_	_	_
22	activated	activated	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
23	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
24	monocytes	monocyte	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
25	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1825
# text = We showed that both IL-10 and IL-4 inhibit LPS-induced IL-6 mRNA and protein expression by inhibiting the transcription rate of the IL-6 gene.
1	We	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
2	showed	show	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
3	that	that	SCONJ	IN	_	_	_	_	_
4	both	both	DET	DT	_	_	_	_	_
5	IL	Il	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
6	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
7	10	10	NUM	CD	NumType=Card	_	_	_	_
8	and	and	CCONJ	CC	_	_	_	_	_
9	IL	Il	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
10	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
11	4	4	NUM	CD	NumType=Card	_	_	_	_
12	inhibit	inhibit	NOUN	NN	Number=Sing	_	_	_	_
13	LPS	Lps	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
14	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
15	induced	induce	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
16	IL	Il	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
17	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
18	6	6	NUM	CD	NumType=Card	_	_	_	_
19	mRNA	mRNa	NOUN	NN	Number=Sing	_	_	_	_
20	and	and	CCONJ	CC	_	_	_	_	_
21	protein	protein	NOUN	NN	Number=Sing	_	_	_	_
22	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
23	by	by	SCONJ	IN	_	_	_	_	_
24	inhibiting	inhibit	VERB	VBG	VerbForm=Ger	_	_	_	_
25	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
26	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
27	rate	rate	NOUN	NN	Number=Sing	_	_	_	_
28	of	of	ADP	IN	_	_	_	_	_
29	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
30	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
31	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
32	6	6	NUM	CD	NumType=Card	_	_	_	_
33	gene	gene	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
34	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1826
# text = The strong inhibition of the IL-6 transcription rate prompted us to study the effect of IL-10 and IL-4 on the expression of transcription factors.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	strong	strong	ADJ	JJ	Degree=Pos	_	_	_	_
3	inhibition	inhibition	NOUN	NN	Number=Sing	_	_	_	_
4	of	of	ADP	IN	_	_	_	_	_
5	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
6	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
7	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
8	6	6	NUM	CD	NumType=Card	_	_	_	_
9	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
10	rate	rate	NOUN	NN	Number=Sing	_	_	_	_
11	prompted	prompt	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
12	us	we	PRON	PRP	Case=Acc|Number=Plur|Person=1|PronType=Prs	_	_	_	_
13	to	to	PART	TO	_	_	_	_	_
14	study	study	VERB	VB	VerbForm=Inf	_	_	_	_
15	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
16	effect	effect	NOUN	NN	Number=Sing	_	_	_	_
17	of	of	ADP	IN	_	_	_	_	_
18	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
19	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
20	10	10	NUM	CD	NumType=Card	_	_	_	_
21	and	and	CCONJ	CC	_	_	_	_	_
22	IL	Il	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
23	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
24	4	4	NUM	CD	NumType=Card	_	_	_	_
25	on	on	ADP	IN	_	_	_	_	_
26	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
27	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
28	of	of	ADP	IN	_	_	_	_	_
29	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
30	factors	factor	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
31	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1827
# text = We questioned whether or not IL-10 and IL-4 affected the expression of transcription factors that are known to be involved in the control of the IL-6 transcription rate, namely activator protein-1 (AP-1), nuclear factor IL-6 (NF-IL6), and nuclear factor kappa B (NF-kappaB).
1	We	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
2	questioned	question	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
3	whether	whether	SCONJ	IN	_	_	_	_	_
4	or	or	CCONJ	CC	_	_	_	_	_
5	not	not	ADV	RB	_	_	_	_	_
6	IL	Il	ADV	RB	_	_	_	_	SpaceAfter=No
7	-	-	SYM	SYM	_	_	_	_	SpaceAfter=No
8	10	10	NUM	CD	NumType=Card	_	_	_	_
9	and	and	CCONJ	CC	_	_	_	_	_
10	IL	Il	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
11	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
12	4	4	NUM	CD	NumType=Card	_	_	_	_
13	affected	affect	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
14	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
15	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
16	of	of	ADP	IN	_	_	_	_	_
17	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
18	factors	factor	NOUN	NNS	Number=Plur	_	_	_	_
19	that	that	PRON	WDT	PronType=Rel	_	_	_	_
20	are	be	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
21	known	know	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
22	to	to	PART	TO	_	_	_	_	_
23	be	be	AUX	VB	VerbForm=Inf	_	_	_	_
24	involved	involved	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
25	in	in	ADP	IN	_	_	_	_	_
26	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
27	control	control	NOUN	NN	Number=Sing	_	_	_	_
28	of	of	ADP	IN	_	_	_	_	_
29	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
30	IL	Il	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
31	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
32	6	6	NUM	CD	NumType=Card	_	_	_	_
33	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
34	rate	rate	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
35	,	,	PUNCT	,	_	_	_	_	_
36	namely	namely	ADV	RB	_	_	_	_	_
37	activator	activator	NOUN	NN	Number=Sing	_	_	_	_
38	protein	protein	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
39	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
40	1	1	NUM	CD	NumType=Card	_	_	_	_
41	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
42	AP	ap	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
43	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
44	1	1	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
45	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
46	,	,	PUNCT	,	_	_	_	_	_
47	nuclear	nuclear	ADJ	JJ	Degree=Pos	_	_	_	_
48	factor	factor	NOUN	NN	Number=Sing	_	_	_	_
49	IL	Il	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
50	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
51	6	6	NUM	CD	NumType=Card	_	_	_	_
52	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
53	NF	Nf	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
54	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
55	IL6	Il6	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
56	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
57	,	,	PUNCT	,	_	_	_	_	_
58	and	and	CCONJ	CC	_	_	_	_	_
59	nuclear	nuclear	ADJ	JJ	Degree=Pos	_	_	_	_
60	factor	factor	NOUN	NN	Number=Sing	_	_	_	_
61	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_
62	B	b	PROPN	NNP	Number=Sing	_	_	_	_
63	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
64	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
65	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
66	kappaB	kappaB	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
67	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
68	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1828
# text = In electrophoretic mobility shift assays (EMSAs) we showed that IL-10 and IL-4 inhibited LPS-induced AP-1 binding activity.
1	In	in	ADP	IN	_	_	_	_	_
2	electrophoretic	electrophoretic	ADJ	JJ	Degree=Pos	_	_	_	_
3	mobility	mobility	NOUN	NN	Number=Sing	_	_	_	_
4	shift	shift	NOUN	NN	Number=Sing	_	_	_	_
5	assays	assay	NOUN	NNS	Number=Plur	_	_	_	_
6	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
7	EMSAs	EMSAs	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
8	)	)	PUNCT	-RRB-	_	_	_	_	_
9	we	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
10	showed	show	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
11	that	that	SCONJ	IN	_	_	_	_	_
12	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
13	-	-	SYM	SYM	_	_	_	_	SpaceAfter=No
14	10	10	NUM	CD	NumType=Card	_	_	_	_
15	and	and	CCONJ	CC	_	_	_	_	_
16	IL	Il	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
17	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
18	4	4	NUM	CD	NumType=Card	_	_	_	_
19	inhibited	inhibit	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
20	LPS	LPS	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
21	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
22	induced	induce	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
23	AP	ap	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
24	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
25	1	1	NUM	CD	NumType=Card	_	_	_	_
26	binding	binding	VERB	VBG	VerbForm=Ger	_	_	_	_
27	activity	activity	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
28	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1829
# text = The inhibiting effect of IL-4 was slightly more pronounced than that of IL-10.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	inhibiting	inhibit	NOUN	NN	Number=Sing	_	_	_	_
3	effect	effect	NOUN	NN	Number=Sing	_	_	_	_
4	of	of	ADP	IN	_	_	_	_	_
5	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
6	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
7	4	4	NUM	CD	NumType=Card	_	_	_	_
8	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
9	slightly	slightly	ADV	RB	_	_	_	_	_
10	more	more	ADV	RBR	_	_	_	_	_
11	pronounced	pronounced	ADJ	JJ	Degree=Pos	_	_	_	_
12	than	than	ADP	IN	_	_	_	_	_
13	that	that	PRON	DT	Number=Sing|PronType=Dem	_	_	_	_
14	of	of	ADP	IN	_	_	_	_	_
15	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
16	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
17	10	10	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
18	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1830
# text = Downregulation of LPS-induced AP-1 was accompanied, and thus possibly explained, by a reduced expression at mRNA level of the two major components of the AP-1 complex, namely c-fos and c-jun as determined by Northern experiments.
1	Downregulation	Downregulation	NOUN	NN	Number=Sing	_	_	_	_
2	of	of	ADP	IN	_	_	_	_	_
3	LPS	LPS	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
4	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
5	induced	induce	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
6	AP	ap	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
7	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
8	1	1	NUM	CD	NumType=Card	_	_	_	_
9	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
10	accompanied	accompanied	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
11	,	,	PUNCT	,	_	_	_	_	_
12	and	and	CCONJ	CC	_	_	_	_	_
13	thus	thus	ADV	RB	_	_	_	_	_
14	possibly	possibly	ADV	RB	_	_	_	_	_
15	explained	explain	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	SpaceAfter=No
16	,	,	PUNCT	,	_	_	_	_	_
17	by	by	ADP	IN	_	_	_	_	_
18	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
19	reduced	reduce	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
20	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
21	at	at	ADP	IN	_	_	_	_	_
22	mRNA	mRNA	PROPN	NNP	Number=Sing	_	_	_	_
23	level	level	NOUN	NN	Number=Sing	_	_	_	_
24	of	of	ADP	IN	_	_	_	_	_
25	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
26	two	two	NUM	CD	NumType=Card	_	_	_	_
27	major	major	ADJ	JJ	Degree=Pos	_	_	_	_
28	components	component	NOUN	NNS	Number=Plur	_	_	_	_
29	of	of	ADP	IN	_	_	_	_	_
30	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
31	AP	ap	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
32	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
33	1	1	NUM	CD	NumType=Card	_	_	_	_
34	complex	complex	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
35	,	,	PUNCT	,	_	_	_	_	_
36	namely	namely	ADV	RB	_	_	_	_	_
37	c-	c-	SYM	NFP	_	_	_	_	SpaceAfter=No
38	fos	fo	NOUN	NNS	Number=Plur	_	_	_	_
39	and	and	CCONJ	CC	_	_	_	_	_
40	c-	c-	SYM	NFP	_	_	_	_	SpaceAfter=No
41	jun	jun	NOUN	NN	Number=Sing	_	_	_	_
42	as	as	SCONJ	IN	_	_	_	_	_
43	determined	determine	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
44	by	by	ADP	IN	_	_	_	_	_
45	Northern	Northern	ADJ	JJ	Degree=Pos	_	_	_	_
46	experiments	experiment	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
47	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1831
# text = Binding activity of NF-IL6 was also strongly inhibited by IL-4 whereas IL-10 showed no effect.
1	Binding	bind	VERB	VBG	VerbForm=Ger	_	_	_	_
2	activity	activity	NOUN	NN	Number=Sing	_	_	_	_
3	of	of	ADP	IN	_	_	_	_	_
4	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
5	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
6	IL6	Il6	PROPN	NNP	Number=Sing	_	_	_	_
7	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
8	also	also	ADV	RB	_	_	_	_	_
9	strongly	strongly	ADV	RB	_	_	_	_	_
10	inhibited	inhibit	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
11	by	by	ADP	IN	_	_	_	_	_
12	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
13	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
14	4	4	NUM	CD	NumType=Card	_	_	_	_
15	whereas	wherea	NOUN	NNS	Number=Plur	_	_	_	_
16	IL	Il	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
17	-	-	SYM	SYM	_	_	_	_	SpaceAfter=No
18	10	10	NUM	CD	NumType=Card	_	_	_	_
19	showed	show	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
20	no	no	DET	DT	_	_	_	_	_
21	effect	effect	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
22	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1832
# text = NF-IL6 mRNA levels were not affected by IL-10 or IL-4, suggesting that IL-4 affects binding activity of preexisting NF-IL6.
1	NF	Nf	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
2	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
3	IL6	IL6	PROPN	NNP	Number=Sing	_	_	_	_
4	mRNA	mRNa	PROPN	NNP	Number=Sing	_	_	_	_
5	levels	level	NOUN	NNS	Number=Plur	_	_	_	_
6	were	be	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
7	not	not	PART	RB	_	_	_	_	_
8	affected	affect	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
9	by	by	ADP	IN	_	_	_	_	_
10	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
11	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
12	10	10	NUM	CD	NumType=Card	_	_	_	_
13	or	or	CCONJ	CC	_	_	_	_	_
14	IL	Il	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
15	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
16	4	4	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
17	,	,	PUNCT	,	_	_	_	_	_
18	suggesting	suggest	VERB	VBG	VerbForm=Ger	_	_	_	_
19	that	that	SCONJ	IN	_	_	_	_	_
20	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
21	-	-	SYM	SYM	_	_	_	_	SpaceAfter=No
22	4	4	NUM	CD	NumType=Card	_	_	_	_
23	affects	affect	NOUN	NNS	Number=Plur	_	_	_	_
24	binding	bind	VERB	VBG	VerbForm=Ger	_	_	_	_
25	activity	activity	NOUN	NN	Number=Sing	_	_	_	_
26	of	of	SCONJ	IN	_	_	_	_	_
27	preexisting	preexist	VERB	VBG	VerbForm=Ger	_	_	_	_
28	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
29	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
30	IL6	Il6	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
31	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1833
# text = Neither IL-10 nor IL-4 inhibited LPS-induced NF-kappa B binding activity.
1	Neither	neither	DET	DT	_	_	_	_	_
2	IL	Il	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
3	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
4	10	10	NUM	CD	NumType=Card	_	_	_	_
5	nor	nor	NOUN	NN	Number=Sing	_	_	_	_
6	IL	Il	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
7	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
8	4	4	NUM	CD	NumType=Card	_	_	_	_
9	inhibited	inhibit	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
10	LPS	Lps	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
11	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
12	induced	induce	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
13	NF	Nf	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
14	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
15	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_
16	B	b	NOUN	NN	Number=Sing	_	_	_	_
17	binding	binde	VERB	VBG	VerbForm=Ger	_	_	_	_
18	activity	activity	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
19	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1834
# text = In agreement with this finding, Northern experiments where p65 and p105 mRNA levels were determined, demonstrated that expression of these components of the NF-kappa B transcription factor were not affected by IL-10 or IL-4.
1	In	in	ADP	IN	_	_	_	_	_
2	agreement	agreement	NOUN	NN	Number=Sing	_	_	_	_
3	with	with	ADP	IN	_	_	_	_	_
4	this	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
5	finding	finding	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
6	,	,	PUNCT	,	_	_	_	_	_
7	Northern	Northern	ADJ	JJ	Degree=Pos	_	_	_	_
8	experiments	experiment	NOUN	NNS	Number=Plur	_	_	_	_
9	where	where	ADV	WRB	PronType=Rel	_	_	_	_
10	p65	p65	NUM	CD	NumType=Card	_	_	_	_
11	and	and	CCONJ	CC	_	_	_	_	_
12	p105	p105	NUM	CD	NumType=Card	_	_	_	_
13	mRNA	mRNa	NOUN	NN	Number=Sing	_	_	_	_
14	levels	level	NOUN	NNS	Number=Plur	_	_	_	_
15	were	be	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
16	determined	determine	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	SpaceAfter=No
17	,	,	PUNCT	,	_	_	_	_	_
18	demonstrated	demonstrate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
19	that	that	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
20	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
21	of	of	ADP	IN	_	_	_	_	_
22	these	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
23	components	component	NOUN	NNS	Number=Plur	_	_	_	_
24	of	of	ADP	IN	_	_	_	_	_
25	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
26	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
27	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
28	kappa	kappa	PROPN	NNP	Number=Sing	_	_	_	_
29	B	b	PROPN	NNP	Number=Sing	_	_	_	_
30	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
31	factor	factor	NOUN	NN	Number=Sing	_	_	_	_
32	were	be	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
33	not	not	PART	RB	_	_	_	_	_
34	affected	affect	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
35	by	by	ADP	IN	_	_	_	_	_
36	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
37	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
38	10	10	NUM	CD	NumType=Card	_	_	_	_
39	or	or	CCONJ	CC	_	_	_	_	_
40	IL	il	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
41	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
42	4	4	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
43	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1835
# text = Furthermore, neither IL-10 nor IL-4 showed any effect on
1	Furthermore	furthermore	ADV	RB	_	_	_	_	SpaceAfter=No
2	,	,	PUNCT	,	_	_	_	_	_
3	neither	neither	DET	DT	_	_	_	_	_
4	IL	Il	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
5	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
6	10	10	NUM	CD	NumType=Card	_	_	_	_
7	nor	nor	NOUN	NN	Number=Sing	_	_	_	_
8	IL	Il	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
9	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
10	4	4	NUM	CD	NumType=Card	_	_	_	_
11	showed	show	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
12	any	any	DET	DT	_	_	_	_	_
13	effect	effect	NOUN	NN	Number=Sing	_	_	_	_
14	on	on	ADP	IN	_	_	_	_	_

# sent_id = 1836
# text = I-kappa B mRNA expression as determined by Northern experiments.
1	I	I	PRON	PRP	Case=Nom|Number=Sing|Person=1|PronType=Prs	_	_	_	SpaceAfter=No
2	-	-	PUNCT	NFP	_	_	_	_	SpaceAfter=No
3	kappa	kappa	X	GW	_	_	_	_	_
4	B	b	X	GW	_	_	_	_	_
5	mRNA	mRNa	X	GW	_	_	_	_	_
6	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
7	as	as	SCONJ	IN	_	_	_	_	_
8	determined	determine	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
9	by	by	ADP	IN	_	_	_	_	_
10	Northern	Northern	ADJ	JJ	Degree=Pos	_	_	_	_
11	experiments	experiment	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
12	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1837
# text = Thus, IL-10 and IL-4 similarly affect IL-6 expression.
1	Thus	thus	ADV	RB	_	_	_	_	SpaceAfter=No
2	,	,	PUNCT	,	_	_	_	_	_
3	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
4	-	-	SYM	SYM	_	_	_	_	SpaceAfter=No
5	10	10	NUM	CD	NumType=Card	_	_	_	_
6	and	and	CCONJ	CC	_	_	_	_	_
7	IL	Il	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
8	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
9	4	4	NUM	CD	NumType=Card	_	_	_	_
10	similarly	similarly	ADJ	JJ	Degree=Pos	_	_	_	_
11	affect	affect	NOUN	NN	Number=Sing	_	_	_	_
12	IL	Il	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
13	-	-	PUNCT	:	_	_	_	_	SpaceAfter=No
14	6	6	NUM	CD	NumType=Card	_	_	_	_
15	expression	expression	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
16	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1838
# text = However, for IL-4 this was accompanied with a reduction of AP-1 and NF-IL6 binding activity whereas IL-10 only inhibited AP-1 binding activity.
1	However	however	ADV	RB	_	_	_	_	SpaceAfter=No
2	,	,	PUNCT	,	_	_	_	_	_
3	for	for	ADP	IN	_	_	_	_	_
4	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
5	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
6	4	4	NUM	CD	NumType=Card	_	_	_	_
7	this	this	PRON	DT	Number=Sing|PronType=Dem	_	_	_	_
8	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
9	accompanied	accompany	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
10	with	with	ADP	IN	_	_	_	_	_
11	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
12	reduction	reduction	NOUN	NN	Number=Sing	_	_	_	_
13	of	of	ADP	IN	_	_	_	_	_
14	AP	ap	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
15	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
16	1	1	NUM	CD	NumType=Card	_	_	_	_
17	and	and	CCONJ	CC	_	_	_	_	_
18	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
19	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
20	IL6	IL6	PROPN	NNP	Number=Sing	_	_	_	_
21	binding	bind	VERB	VBG	VerbForm=Ger	_	_	_	_
22	activity	activity	NOUN	NN	Number=Sing	_	_	_	_
23	whereas	whereas	NOUN	NNS	Number=Plur	_	_	_	_
24	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
25	-	-	SYM	SYM	_	_	_	_	SpaceAfter=No
26	10	10	NUM	CD	NumType=Card	_	_	_	_
27	only	only	ADV	RB	_	_	_	_	_
28	inhibited	inhibit	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
29	AP	ap	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
30	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
31	1	1	NUM	CD	NumType=Card	_	_	_	_
32	binding	binding	VERB	VBG	VerbForm=Ger	_	_	_	_
33	activity	activity	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
34	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 1839
# text = Document 00300363 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	00300363	00300363	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 1840
# text = Thyroid hormone receptors form distinct nuclear protein-dependent and independent complexes with a thyroid hormone response element.
1	Thyroid	thyroid	ADJ	JJ	Degree=Pos	_	_	_	_
2	hormone	hormone	NOUN	NN	Number=Sing	_	_	_	_
3	receptors	receptor	NOUN	NNS	Number=Plur	_	_	_	_
4	form	form	ADP	IN	Typo=Yes	_	_	_	_
5	distinct	distinct	ADJ	JJ	Degree=Pos	_	_	_	_
6	nuclear	nuclear	ADJ	JJ	Degree=Pos	_	_	_	_
7	protein-	protein-	SYM	NFP	_	_	_	_	SpaceAfter=No
8	dependent	dependent	ADJ	JJ	Degree=Pos	_	_	_	_
9	and	and	CCONJ	CC	_	_	_	_	_
10	independent	independent	ADJ	JJ	Degree=Pos	_	_	_	_
11	complexes	complexe	NOUN	NNS	Number=Plur	_	_	_	_
12	with	with	ADP	IN	_	_	_	_	_
13	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
14	thyroid	thyroid	NOUN	NN	Number=Sing	_	_	_	_
15	hormone	hormone	NOUN	NN	Number=Sing	_	_	_	_
16	response	response	NOUN	NN	Number=Sing	_	_	_	_
17	element	element	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
18	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 1841
# text = We have examined the binding of nuclear proteins and recombinant thyroid hormone receptors (TRs) to the palindromic thyroid hormone responsive element AGGTCATGACCT (TREp) using a gel electrophoretic mobility shift assay.
1	We	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
2	have	have	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
3	examined	examine	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
4	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
5	binding	binding	NOUN	NN	Number=Sing	_	_	_	_
6	of	of	ADP	IN	_	_	_	_	_
7	nuclear	nuclear	ADJ	JJ	Degree=Pos	_	_	_	_
8	proteins	protein	NOUN	NNS	Number=Plur	_	_	_	_
9	and	and	CCONJ	CC	_	_	_	_	_
10	recombinant	recombinant	ADJ	JJ	Degree=Pos	_	_	_	_
11	thyroid	thyroid	NOUN	NN	Number=Sing	_	_	_	_
12	hormone	hormone	NOUN	NN	Number=Sing	_	_	_	_
13	receptors	receptor	NOUN	NNS	Number=Plur	_	_	_	_
14	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
15	TRs	TRs	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
16	)	)	PUNCT	-RRB-	_	_	_	_	_
17	to	to	ADP	IN	_	_	_	_	_
18	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
19	palindromic	palindromic	ADJ	JJ	Degree=Pos	_	_	_	_
20	thyroid	thyroid	NOUN	NN	Number=Sing	_	_	_	_
21	hormone	hormone	NOUN	NN	Number=Sing	_	_	_	_
22	responsive	responsive	ADJ	JJ	Degree=Pos	_	_	_	_
23	element	element	NOUN	NN	Number=Sing	_	_	_	_
24	AGGTCATGACCT	AGGTCATGACCT	PROPN	NNP	Number=Sing	_	_	_	_
25	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
26	TREp	TREp	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
27	)	)	PUNCT	-RRB-	_	_	_	_	_
28	using	use	VERB	VBG	VerbForm=Ger	_	_	_	_
29	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
30	gel	gel	NOUN	NN	Number=Sing	_	_	_	_
31	electrophoretic	electrophoretic	ADJ	JJ	Degree=Pos	_	_	_	_
32	mobility	mobility	NOUN	NN	Number=Sing	_	_	_	_
33	shift	shift	NOUN	NN	Number=Sing	_	_	_	_
34	assay	assay	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
35	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1842
# text = Four specific protein-DNA complexes were detected after incubation of nuclear extracts (NE) from T3-responsive pituitary (GH3) cells with a TREp-containing DNA fragment.
1	Four	four	NUM	CD	NumType=Card	_	_	_	_
2	specific	specific	ADJ	JJ	Degree=Pos	_	_	_	_
3	protein	protein	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
4	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
5	DNA	dna	NOUN	NN	Number=Sing	_	_	_	_
6	complexes	complex	NOUN	NNS	Number=Plur	_	_	_	_
7	were	be	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
8	detected	detect	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
9	after	after	ADP	IN	_	_	_	_	_
10	incubation	incubation	NOUN	NN	Number=Sing	_	_	_	_
11	of	of	ADP	IN	_	_	_	_	_
12	nuclear	nuclear	ADJ	JJ	Degree=Pos	_	_	_	_
13	extracts	extract	NOUN	NNS	Number=Plur	_	_	_	_
14	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
15	NE	NE	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
16	)	)	PUNCT	-RRB-	_	_	_	_	_
17	from	from	ADP	IN	_	_	_	_	_
18	T3	T3	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
19	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
20	responsive	responsive	ADJ	JJ	Degree=Pos	_	_	_	_
21	pituitary	pituitary	NOUN	NN	Number=Sing	_	_	_	_
22	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
23	GH3	GH3	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
24	)	)	PUNCT	-RRB-	_	_	_	_	_
25	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
26	with	with	ADP	IN	_	_	_	_	_
27	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
28	TREp	TREp	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
29	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
30	containing	contain	VERB	VBG	VerbForm=Ger	_	_	_	_
31	DNA	dna	NOUN	NN	Number=Sing	_	_	_	_
32	fragment	fragment	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
33	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1843
# text = This was compared with the TREp binding of reticulocyte lysate-synthesized TRs.
1	This	this	PRON	DT	Number=Sing|PronType=Dem	_	_	_	_
2	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
3	compared	compare	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
4	with	with	ADP	IN	_	_	_	_	_
5	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
6	TREp	TREp	NOUN	NN	Number=Sing	_	_	_	_
7	binding	binding	VERB	VBG	VerbForm=Ger	_	_	_	_
8	of	of	ADP	IN	_	_	_	_	_
9	reticulocyte	reticulocyte	NOUN	NN	Number=Sing	_	_	_	_
10	lysate	lysate	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
11	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
12	synthesized	synthesize	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
13	TRs	TR	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
14	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1844
# text = TR alpha 1 and TR beta 2 each formed a single major TR:TREp complex which comigrated with the least retarded complex formed by GH3 NE, while TR beta 1 formed multiple complexes suggesting that it can bind to TREp as an oligomer.
1	TR	Tr	VERB	VB	Mood=Imp|VerbForm=Fin	_	_	_	_
2	alpha	alpha	ADV	RB	_	_	_	_	_
3	1	1	NUM	CD	NumType=Card	_	_	_	_
4	and	and	CCONJ	CC	_	_	_	_	_
5	TR	Tr	ADJ	JJR	Degree=Cmp	_	_	_	_
6	beta	beta	NOUN	NN	Number=Sing	_	_	_	_
7	2	2	NUM	CD	NumType=Card	_	_	_	_
8	each	each	DET	DT	_	_	_	_	_
9	formed	form	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
10	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
11	single	single	ADJ	JJ	Degree=Pos	_	_	_	_
12	major	major	ADJ	JJ	Degree=Pos	_	_	_	_
13	TR:	Tr:	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
14	TREp	TREp	NOUN	NN	Number=Sing	_	_	_	_
15	complex	complex	NOUN	NN	Number=Sing	_	_	_	_
16	which	which	PRON	WDT	PronType=Rel	_	_	_	_
17	comigrated	comigrate	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
18	with	with	ADP	IN	_	_	_	_	_
19	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
20	least	least	ADJ	JJS	Degree=Sup	_	_	_	_
21	retarded	retard	ADJ	JJ	Degree=Pos	_	_	_	_
22	complex	complex	NOUN	NN	Number=Sing	_	_	_	_
23	formed	form	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
24	by	by	ADP	IN	_	_	_	_	_
25	GH3	GH3	NOUN	NN	Number=Sing	_	_	_	_
26	NE	Ne	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
27	,	,	PUNCT	,	_	_	_	_	_
28	while	while	SCONJ	IN	_	_	_	_	_
29	TR	TR	PROPN	NNP	Number=Sing	_	_	_	_
30	beta	beta	PROPN	NNP	Number=Sing	_	_	_	_
31	1	1	NUM	CD	NumType=Card	_	_	_	_
32	formed	form	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
33	multiple	multiple	ADJ	JJ	Degree=Pos	_	_	_	_
34	complexes	complex	NOUN	NNS	Number=Plur	_	_	_	_
35	suggesting	suggest	VERB	VBG	VerbForm=Ger	_	_	_	_
36	that	that	SCONJ	IN	_	_	_	_	_
37	it	it	PRON	PRP	Case=Nom|Gender=Neut|Number=Sing|Person=3|PronType=Prs	_	_	_	_
38	can	can	AUX	MD	VerbForm=Fin	_	_	_	_
39	bind	bind	VERB	VB	VerbForm=Inf	_	_	_	_
40	to	to	PART	TO	_	_	_	_	_
41	TREp	TREp	VERB	VB	VerbForm=Inf	_	_	_	_
42	as	as	ADP	IN	_	_	_	_	_
43	an	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
44	oligomer	oligomer	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
45	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1845
# text = Interestingly, coincubation of 35S-TR alpha 1, GH3 NE, and unlabeled TREp resulted in not only the 35S-TR:TREp complex, but in two additional more greatly retarded complexes containing 35S-TR alpha 1 and comigrating with those formed by GH3 extract alone.
1	Interestingly	Interestingly	ADV	RB	_	_	_	_	SpaceAfter=No
2	,	,	PUNCT	,	_	_	_	_	_
3	coincubation	coincubation	NOUN	NN	Number=Sing	_	_	_	_
4	of	of	ADP	IN	_	_	_	_	_
5	35S	35S	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
6	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
7	TR	TR	PROPN	NNP	Number=Sing	_	_	_	_
8	alpha	alpha	NOUN	NN	Number=Sing	_	_	_	_
9	1	1	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
10	,	,	PUNCT	,	_	_	_	_	_
11	GH3	GH3	NUM	CD	NumType=Card	_	_	_	_
12	NE	NE	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
13	,	,	PUNCT	,	_	_	_	_	_
14	and	and	CCONJ	CC	_	_	_	_	_
15	unlabeled	unlabel	ADJ	JJ	Degree=Pos	_	_	_	_
16	TREp	TREp	PROPN	NNP	Number=Sing	_	_	_	_
17	resulted	result	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
18	in	in	ADP	IN	_	_	_	_	_
19	not	not	ADV	RB	_	_	_	_	_
20	only	only	ADV	RB	_	_	_	_	_
21	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
22	35S	35S	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
23	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
24	TR:TREp	TR:TREp	NOUN	NN	Number=Sing	_	_	_	_
25	complex	complex	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
26	,	,	PUNCT	,	_	_	_	_	_
27	but	but	CCONJ	CC	_	_	_	_	_
28	in	in	ADP	IN	_	_	_	_	_
29	two	two	NUM	CD	NumType=Card	_	_	_	_
30	additional	additional	ADJ	JJ	Degree=Pos	_	_	_	_
31	more	more	ADV	RBR	_	_	_	_	_
32	greatly	greatly	ADV	RB	_	_	_	_	_
33	retarded	retarded	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
34	complexes	complexe	NOUN	NNS	Number=Plur	_	_	_	_
35	containing	contain	VERB	VBG	VerbForm=Ger	_	_	_	_
36	35S	35S	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
37	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
38	TR	TR	PROPN	NNP	Number=Sing	_	_	_	_
39	alpha	alpha	ADP	IN	_	_	_	_	_
40	1	1	NUM	CD	NumType=Card	_	_	_	_
41	and	and	CCONJ	CC	_	_	_	_	_
42	comigrating	comigrat	VERB	VBG	VerbForm=Ger	_	_	_	_
43	with	with	ADP	IN	_	_	_	_	_
44	those	those	PRON	DT	Number=Plur|PronType=Dem	_	_	_	_
45	formed	form	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
46	by	by	ADP	IN	_	_	_	_	_
47	GH3	GH3	NUM	CD	NumType=Card	_	_	_	_
48	extract	extract	NOUN	NN	Number=Sing	_	_	_	_
49	alone	alone	ADV	RB	_	_	_	_	SpaceAfter=No
50	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1846
# text = Incubation of each of the TRs with NE from COS-7 cells, which do not possess sufficient endogenous TRs to mediate T3-responses, resulted in formation of a new, more greatly shifted complex.
1	Incubation	incubation	NOUN	NN	Number=Sing	_	_	_	_
2	of	of	ADP	IN	_	_	_	_	_
3	each	each	DET	DT	_	_	_	_	_
4	of	of	ADP	IN	_	_	_	_	_
5	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
6	TRs	TRs	PROPN	NNPS	Number=Plur	_	_	_	_
7	with	with	ADP	IN	_	_	_	_	_
8	NE	NE	PROPN	NNP	Number=Sing	_	_	_	_
9	from	from	ADP	IN	_	_	_	_	_
10	COS	COS	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
11	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
12	7	7	NUM	CD	NumType=Card	_	_	_	_
13	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
14	,	,	PUNCT	,	_	_	_	_	_
15	which	which	PRON	WDT	PronType=Rel	_	_	_	_
16	do	do	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
17	not	not	PART	RB	_	_	_	_	_
18	possess	possess	VERB	VB	VerbForm=Inf	_	_	_	_
19	sufficient	sufficient	ADJ	JJ	Degree=Pos	_	_	_	_
20	endogenous	endogenous	ADJ	JJ	Degree=Pos	_	_	_	_
21	TRs	TR	NOUN	NNS	Number=Plur	_	_	_	_
22	to	to	PART	TO	_	_	_	_	_
23	mediate	mediate	VERB	VB	VerbForm=Inf	_	_	_	_
24	T3	T3	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
25	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
26	responses	response	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
27	,	,	PUNCT	,	_	_	_	_	_
28	resulted	result	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
29	in	in	ADP	IN	_	_	_	_	_
30	formation	formation	NOUN	NN	Number=Sing	_	_	_	_
31	of	of	ADP	IN	_	_	_	_	_
32	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
33	new	new	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
34	,	,	PUNCT	,	_	_	_	_	_
35	more	more	ADV	RBR	_	_	_	_	_
36	greatly	greatly	ADV	RB	_	_	_	_	_
37	shifted	shifte	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
38	complex	complex	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
39	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1847
# text = A similar, heat labile activity which altered mobility of the TR:TRE complex was also present in NE from T3-unresponsive JEG-3 cells.
1	A	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
2	similar	similar	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
3	,	,	PUNCT	,	_	_	_	_	_
4	heat	heat	NOUN	NN	Number=Sing	_	_	_	_
5	labile	labile	ADJ	JJ	Degree=Pos	_	_	_	_
6	activity	activity	NOUN	NN	Number=Sing	_	_	_	_
7	which	which	PRON	WDT	PronType=Rel	_	_	_	_
8	altered	alter	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
9	mobility	mobility	NOUN	NN	Number=Sing	_	_	_	_
10	of	of	ADP	IN	_	_	_	_	_
11	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
12	TR:	Tr:	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
13	TRE	Tre	NOUN	NN	Number=Sing	_	_	_	_
14	complex	complex	NOUN	NN	Number=Sing	_	_	_	_
15	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
16	also	also	ADV	RB	_	_	_	_	_
17	present	present	ADJ	JJ	Degree=Pos	_	_	_	_
18	in	in	ADP	IN	_	_	_	_	_
19	NE	NE	PROPN	NNP	Number=Sing	_	_	_	_
20	from	from	ADP	IN	_	_	_	_	_
21	T3	T3	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
22	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
23	unresponsive	unresponsive	ADJ	JJ	Degree=Pos	_	_	_	_
24	JEG	JEG	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
25	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
26	3	3	NUM	CD	NumType=Card	_	_	_	_
27	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
28	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1848
# text = At high concentration of NE, all of the TR bound to TREp was more greatly retarded than in the absence of NE.
1	At	at	ADP	IN	_	_	_	_	_
2	high	high	ADJ	JJ	Degree=Pos	_	_	_	_
3	concentration	concentration	NOUN	NN	Number=Sing	_	_	_	_
4	of	of	ADP	IN	_	_	_	_	_
5	NE	Ne	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
6	,	,	PUNCT	,	_	_	_	_	_
7	all	all	DET	DT	_	_	_	_	_
8	of	of	ADP	IN	_	_	_	_	_
9	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
10	TR	TR	PROPN	NNP	Number=Sing	_	_	_	_
11	bound	bound	ADJ	JJ	Degree=Pos	_	_	_	_
12	to	to	ADP	IN	_	_	_	_	_
13	TREp	TREp	PROPN	NNP	Number=Sing	_	_	_	_
14	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
15	more	more	ADV	RBR	_	_	_	_	_
16	greatly	greatly	ADV	RB	_	_	_	_	_
17	retarded	retard	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
18	than	than	ADP	IN	_	_	_	_	_
19	in	in	ADP	IN	_	_	_	_	_
20	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
21	absence	absence	NOUN	NN	Number=Sing	_	_	_	_
22	of	of	ADP	IN	_	_	_	_	_
23	NE	NE	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
24	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1849
# text = Truncation of TR alpha 1 at amino acid 210 prevented additional complex formation in the presence of NE without affecting DNA binding, suggesting that the carboxyl-terminus of the TRs is essential for interaction with nuclear proteins.
1	Truncation	Truncation	NOUN	NN	Number=Sing	_	_	_	_
2	of	of	ADP	IN	_	_	_	_	_
3	TR	TR	PROPN	NNP	Number=Sing	_	_	_	_
4	alpha	alpha	NOUN	NN	Number=Sing	_	_	_	_
5	1	1	NUM	CD	NumType=Card	_	_	_	_
6	at	at	ADP	IN	_	_	_	_	_
7	amino	amino	DET	DT	_	_	_	_	_
8	acid	acid	ADJ	JJ	Degree=Pos	_	_	_	_
9	210	210	NUM	CD	NumType=Card	_	_	_	_
10	prevented	prevent	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
11	additional	additional	ADJ	JJ	Degree=Pos	_	_	_	_
12	complex	complex	NOUN	NN	Number=Sing	_	_	_	_
13	formation	formation	NOUN	NN	Number=Sing	_	_	_	_
14	in	in	ADP	IN	_	_	_	_	_
15	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
16	presence	presence	NOUN	NN	Number=Sing	_	_	_	_
17	of	of	ADP	IN	_	_	_	_	_
18	NE	NE	PROPN	NNP	Number=Sing	_	_	_	_
19	without	without	SCONJ	IN	_	_	_	_	_
20	affecting	affect	VERB	VBG	VerbForm=Ger	_	_	_	_
21	DNA	dna	NOUN	NN	Number=Sing	_	_	_	_
22	binding	binding	VERB	VBG	VerbForm=Ger	_	_	_	SpaceAfter=No
23	,	,	PUNCT	,	_	_	_	_	_
24	suggesting	suggest	VERB	VBG	VerbForm=Ger	_	_	_	_
25	that	that	SCONJ	IN	_	_	_	_	_
26	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
27	carboxyl	carboxyl	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
28	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
29	terminus	terminus	NOUN	NN	Number=Sing	_	_	_	_
30	of	of	ADP	IN	_	_	_	_	_
31	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
32	TRs	TRs	NOUN	NNS	Number=Plur	_	_	_	_
33	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
34	essential	essential	ADJ	JJ	Degree=Pos	_	_	_	_
35	for	for	ADP	IN	_	_	_	_	_
36	interaction	interaction	NOUN	NN	Number=Sing	_	_	_	_
37	with	with	ADP	IN	_	_	_	_	_
38	nuclear	nuclear	ADJ	JJ	Degree=Pos	_	_	_	_
39	proteins	protein	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
40	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1850
# text = (ABSTRACT TRUNCATED AT 250 WORDS)
1	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
2	ABSTRACT	ABSTRACT	X	GW	_	_	_	_	_
3	TRUNCATED	Truncate	VERB	VB	Mood=Imp|VerbForm=Fin	_	_	_	_
4	AT	at	ADV	RB	_	_	_	_	_
5	250	250	NUM	CD	NumType=Card	_	_	_	_
6	WORDS	words	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
7	)	)	PUNCT	-RRB-	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 1851
# text = Document 00300368 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	00300368	00300368	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 1852
# text = Megakaryocytic and erythrocytic lineages share specific transcription factors.
1	Megakaryocytic	Megakaryocytic	ADJ	JJ	Degree=Pos	_	_	_	_
2	and	and	CCONJ	CC	_	_	_	_	_
3	erythrocytic	erythrocytic	ADJ	JJ	Degree=Pos	_	_	_	_
4	lineages	lineage	NOUN	NNS	Number=Plur	_	_	_	_
5	share	share	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
6	specific	specific	ADJ	JJ	Degree=Pos	_	_	_	_
7	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
8	factors	factor	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
9	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 1853
# text = Erythroid-specific genes contain binding sites for NF-E1 (also called GF-1 and Eryf-1; refs 1-3 respectively), the principal DNA-binding protein of the erythrocytic lineage.
1	Erythroid	Erythroid	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
2	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
3	specific	specific	ADJ	JJ	Degree=Pos	_	_	_	_
4	genes	gene	NOUN	NNS	Number=Plur	_	_	_	_
5	contain	contain	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
6	binding	bind	VERB	VBG	VerbForm=Ger	_	_	_	_
7	sites	site	NOUN	NNS	Number=Plur	_	_	_	_
8	for	for	ADP	IN	_	_	_	_	_
9	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
10	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
11	E1	E1	PROPN	NNP	Number=Sing	_	_	_	_
12	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
13	also	also	ADV	RB	_	_	_	_	_
14	called	call	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
15	GF	gf	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
16	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
17	1	1	NUM	CD	NumType=Card	_	_	_	_
18	and	and	CCONJ	CC	_	_	_	_	_
19	Eryf	Eryf	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
20	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
21	1	1	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
22	;	;	PUNCT	,	_	_	_	_	_
23	refs	ref	NOUN	NNS	Number=Plur	_	_	_	_
24	1	1	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
25	-	-	SYM	SYM	_	_	_	_	SpaceAfter=No
26	3	3	NUM	CD	NumType=Card	_	_	_	_
27	respectively	respectively	ADV	RB	_	_	_	_	SpaceAfter=No
28	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
29	,	,	PUNCT	,	_	_	_	_	_
30	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
31	principal	principal	ADJ	JJ	Degree=Pos	_	_	_	_
32	DNA	dna	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
33	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
34	binding	binding	VERB	VBG	VerbForm=Ger	_	_	_	_
35	protein	protein	NOUN	NN	Number=Sing	_	_	_	_
36	of	of	ADP	IN	_	_	_	_	_
37	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
38	erythrocytic	erythrocytic	ADJ	JJ	Degree=Pos	_	_	_	_
39	lineage	lineage	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
40	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1854
# text = NF-E1 expression seems to be restricted to the erythrocytic lineage.
1	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
2	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
3	E1	E1	PROPN	NNP	Number=Sing	_	_	_	_
4	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
5	seems	seem	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
6	to	to	PART	TO	_	_	_	_	_
7	be	be	AUX	VB	VerbForm=Inf	_	_	_	_
8	restricted	restrict	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
9	to	to	ADP	IN	_	_	_	_	_
10	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
11	erythrocytic	erythrocytic	ADJ	JJ	Degree=Pos	_	_	_	_
12	lineage	lineage	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
13	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1855
# text = A closely related (if not identical) protein is found in both a human megakaryocytic cell line and purified human megakaryocytes; it binds to promoter regions of two megakaryocytic-specific genes.
1	A	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
2	closely	closely	ADV	RB	_	_	_	_	_
3	related	related	ADJ	JJ	Degree=Pos	_	_	_	_
4	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
5	if	if	SCONJ	IN	_	_	_	_	_
6	not	not	PART	RB	_	_	_	_	_
7	identical	identical	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
8	)	)	PUNCT	-RRB-	_	_	_	_	_
9	protein	protein	NOUN	NN	Number=Sing	_	_	_	_
10	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
11	found	find	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
12	in	in	ADP	IN	_	_	_	_	_
13	both	both	DET	DT	_	_	_	_	_
14	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
15	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
16	megakaryocytic	megakaryocytic	ADJ	JJ	Degree=Pos	_	_	_	_
17	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
18	line	line	NOUN	NN	Number=Sing	_	_	_	_
19	and	and	CCONJ	CC	_	_	_	_	_
20	purified	purify	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
21	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
22	megakaryocytes	megakaryocyte	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
23	;	;	PUNCT	,	_	_	_	_	_
24	it	it	PRON	PRP	Case=Nom|Gender=Neut|Number=Sing|Person=3|PronType=Prs	_	_	_	_
25	binds	bind	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
26	to	to	PART	TO	_	_	_	_	_
27	promoter	promoter	VERB	VB	VerbForm=Inf	_	_	_	_
28	regions	region	NOUN	NNS	Number=Plur	_	_	_	_
29	of	of	ADP	IN	_	_	_	_	_
30	two	two	NUM	CD	NumType=Card	_	_	_	_
31	megakaryocytic	megakaryocytic	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
32	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
33	specific	specific	ADJ	JJ	Degree=Pos	_	_	_	_
34	genes	gene	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
35	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1856
# text = The binding sites and partial proteolysis profile of this protein are indistinguishable from those of the erythroid protein; also, NF-E1 messenger RNA is the same size in both the megakaryocytic and erythroid cell lines.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	binding	binding	VERB	VBG	VerbForm=Ger	_	_	_	_
3	sites	site	NOUN	NNS	Number=Plur	_	_	_	_
4	and	and	CCONJ	CC	_	_	_	_	_
5	partial	partial	ADJ	JJ	Degree=Pos	_	_	_	_
6	proteolysis	proteolysis	NOUN	NN	Number=Sing	_	_	_	_
7	profile	profile	NOUN	NN	Number=Sing	_	_	_	_
8	of	of	ADP	IN	_	_	_	_	_
9	this	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
10	protein	protein	NOUN	NN	Number=Sing	_	_	_	_
11	are	be	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
12	indistinguishable	indistinguishable	ADJ	JJ	Degree=Pos	_	_	_	_
13	from	from	ADP	IN	_	_	_	_	_
14	those	those	PRON	DT	Number=Plur|PronType=Dem	_	_	_	_
15	of	of	ADP	IN	_	_	_	_	_
16	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
17	erythroid	erythroid	ADJ	JJ	Degree=Pos	_	_	_	_
18	protein	protein	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
19	;	;	PUNCT	,	_	_	_	_	_
20	also	also	ADV	RB	_	_	_	_	SpaceAfter=No
21	,	,	PUNCT	,	_	_	_	_	_
22	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
23	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
24	E1	E1	PROPN	NNP	Number=Sing	_	_	_	_
25	messenger	messenger	NOUN	NN	Number=Sing	_	_	_	_
26	RNA	RNA	PROPN	NNP	Number=Sing	_	_	_	_
27	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
28	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
29	same	same	ADJ	JJ	Degree=Pos	_	_	_	_
30	size	size	NOUN	NN	Number=Sing	_	_	_	_
31	in	in	ADP	IN	_	_	_	_	_
32	both	both	CCONJ	CC	_	_	_	_	_
33	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
34	megakaryocytic	megakaryocytic	ADJ	JJ	Degree=Pos	_	_	_	_
35	and	and	CCONJ	CC	_	_	_	_	_
36	erythroid	erythroid	ADJ	JJ	Degree=Pos	_	_	_	_
37	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
38	lines	line	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
39	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1857
# text = Furthermore, point mutations that abolish binding of NF-E1 result in a 70% decrease in the transcriptional activity of a megakaryocytic-specific promoter.
1	Furthermore	furthermore	ADV	RB	_	_	_	_	SpaceAfter=No
2	,	,	PUNCT	,	_	_	_	_	_
3	point	point	VERB	VB	Mood=Imp|VerbForm=Fin	_	_	_	_
4	mutations	mutation	NOUN	NNS	Number=Plur	_	_	_	_
5	that	that	PRON	WDT	PronType=Rel	_	_	_	_
6	abolish	abolish	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
7	binding	binding	VERB	VBG	VerbForm=Ger	_	_	_	_
8	of	of	ADP	IN	_	_	_	_	_
9	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
10	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
11	E1	e1	PROPN	NNP	Number=Sing	_	_	_	_
12	result	result	NOUN	NN	Number=Sing	_	_	_	_
13	in	in	ADP	IN	_	_	_	_	_
14	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
15	70	70	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
16	%	%	SYM	NN	Number=Sing	_	_	_	_
17	decrease	decrease	NOUN	NN	Number=Sing	_	_	_	_
18	in	in	ADP	IN	_	_	_	_	_
19	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
20	transcriptional	transcriptional	ADJ	JJ	Degree=Pos	_	_	_	_
21	activity	activity	NOUN	NN	Number=Sing	_	_	_	_
22	of	of	ADP	IN	_	_	_	_	_
23	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
24	megakaryocytic	megakaryocytic	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
25	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
26	specific	specific	ADJ	JJ	Degree=Pos	_	_	_	_
27	promoter	promoter	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
28	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1858
# text = We also find that NF-E2, another trans-acting factor of the erythrocytic lineage, is present in megakaryocytes.
1	We	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
2	also	also	ADV	RB	_	_	_	_	_
3	find	find	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
4	that	that	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
5	NF	Nf	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
6	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
7	E2	e2	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
8	,	,	PUNCT	,	_	_	_	_	_
9	another	another	DET	DT	_	_	_	_	_
10	trans	tran	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
11	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
12	acting	act	VERB	VBG	VerbForm=Ger	_	_	_	_
13	factor	factor	NOUN	NN	Number=Sing	_	_	_	_
14	of	of	ADP	IN	_	_	_	_	_
15	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
16	erythrocytic	erythrocytic	ADJ	JJ	Degree=Pos	_	_	_	_
17	lineage	lineage	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
18	,	,	PUNCT	,	_	_	_	_	_
19	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
20	present	present	ADJ	JJ	Degree=Pos	_	_	_	_
21	in	in	ADP	IN	_	_	_	_	_
22	megakaryocytes	megakaryocyte	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
23	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1859
# text = Transcriptional effects in both lineages might then be mediated in part by the same specific trans-acting factors.
1	Transcriptional	Transcriptional	ADJ	JJ	Degree=Pos	_	_	_	_
2	effects	effect	NOUN	NNS	Number=Plur	_	_	_	_
3	in	in	ADP	IN	_	_	_	_	_
4	both	both	DET	DT	_	_	_	_	_
5	lineages	lineage	NOUN	NNS	Number=Plur	_	_	_	_
6	might	might	AUX	MD	VerbForm=Fin	_	_	_	_
7	then	then	ADV	RB	PronType=Dem	_	_	_	_
8	be	be	AUX	VB	VerbForm=Inf	_	_	_	_
9	mediated	mediate	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
10	in	in	ADP	IN	_	_	_	_	_
11	part	part	NOUN	NN	Number=Sing	_	_	_	_
12	by	by	ADP	IN	_	_	_	_	_
13	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
14	same	same	ADJ	JJ	Degree=Pos	_	_	_	_
15	specific	specific	ADJ	JJ	Degree=Pos	_	_	_	_
16	trans	tran	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
17	-acting	-act	VERB	VBG	VerbForm=Ger	_	_	_	_
18	factors	factor	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
19	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1860
# text = Our data strengthen the idea of a close association between the erythrocytic and the megakaryocytic lineages and could also explain the expression of markers specific to the erythrocytic and megakaryocytic lineages in most erythroblastic and megakaryoblastic permanent cell lines.
1	Our	we	PRON	PRP$	Number=Plur|Person=1|Poss=Yes|PronType=Prs	_	_	_	_
2	data	data	NOUN	NN	Number=Sing	_	_	_	_
3	strengthen	strengthan	ADP	IN	Typo=Yes	_	_	_	_
4	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
5	idea	idea	NOUN	NN	Number=Sing	_	_	_	_
6	of	of	ADP	IN	_	_	_	_	_
7	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
8	close	close	ADJ	JJ	Degree=Pos	_	_	_	_
9	association	association	NOUN	NN	Number=Sing	_	_	_	_
10	between	between	ADP	IN	_	_	_	_	_
11	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
12	erythrocytic	erythrocytic	ADJ	JJ	Degree=Pos	_	_	_	_
13	and	and	CCONJ	CC	_	_	_	_	_
14	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
15	megakaryocytic	megakaryocytic	ADJ	JJ	Degree=Pos	_	_	_	_
16	lineages	lineage	NOUN	NNS	Number=Plur	_	_	_	_
17	and	and	CCONJ	CC	_	_	_	_	_
18	could	could	AUX	MD	VerbForm=Fin	_	_	_	_
19	also	also	ADV	RB	_	_	_	_	_
20	explain	explain	VERB	VB	VerbForm=Inf	_	_	_	_
21	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
22	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
23	of	of	ADP	IN	_	_	_	_	_
24	markers	marker	NOUN	NNS	Number=Plur	_	_	_	_
25	specific	specific	ADJ	JJ	Degree=Pos	_	_	_	_
26	to	to	ADP	IN	_	_	_	_	_
27	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
28	erythrocytic	erythrocytic	ADJ	JJ	Degree=Pos	_	_	_	_
29	and	and	CCONJ	CC	_	_	_	_	_
30	megakaryocytic	megakaryocytic	ADJ	JJ	Degree=Pos	_	_	_	_
31	lineages	lineage	NOUN	NNS	Number=Plur	_	_	_	_
32	in	in	ADV	RB	_	_	_	_	_
33	most	most	ADV	RBS	_	_	_	_	_
34	erythroblastic	erythroblastic	ADJ	JJ	Degree=Pos	_	_	_	_
35	and	and	CCONJ	CC	_	_	_	_	_
36	megakaryoblastic	megakaryoblastic	ADJ	JJ	Degree=Pos	_	_	_	_
37	permanent	permanent	ADJ	JJ	Degree=Pos	_	_	_	_
38	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
39	lines	line	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
40	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 1861
# text = Document 00300370 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	00300370	00300370	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 1862
# text = Tumor necrosis factor alpha decreases, and interleukin-10 increases, the sensitivity of human monocytes to dexamethasone: potential regulation of the glucocorticoid receptor.
1	Tumor	tumor	ADP	IN	_	_	_	_	_
2	necrosis	necrosis	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
3	factor	factor	NOUN	NN	Number=Sing	_	_	_	_
4	alpha	alpha	ADP	IN	_	_	_	_	_
5	decreases	decrease	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
6	,	,	PUNCT	,	_	_	_	_	_
7	and	and	CCONJ	CC	_	_	_	_	_
8	interleukin	interleukin	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
9	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
10	10	10	NUM	CD	NumType=Card	_	_	_	_
11	increases	increase	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
12	,	,	PUNCT	,	_	_	_	_	_
13	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
14	sensitivity	sensitivity	NOUN	NN	Number=Sing	_	_	_	_
15	of	of	ADP	IN	_	_	_	_	_
16	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
17	monocytes	monocyte	NOUN	NNS	Number=Plur	_	_	_	_
18	to	to	PART	TO	_	_	_	_	_
19	dexamethasone	dexamethasone	VERB	VB	VerbForm=Inf	_	_	_	SpaceAfter=No
20	:	:	PUNCT	:	_	_	_	_	_
21	potential	potential	ADJ	JJ	Degree=Pos	_	_	_	_
22	regulation	regulation	NOUN	NN	Number=Sing	_	_	_	_
23	of	of	ADP	IN	_	_	_	_	_
24	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
25	glucocorticoid	glucocorticoid	ADJ	JJ	Degree=Pos	_	_	_	_
26	receptor	receptor	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
27	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 1863
# text = Resistance to glucocorticoid therapy has been observed in patients with autoimmune/inflammatory diseases and may be related to the inflammatory process itself.
1	Resistance	resistance	NOUN	NN	Number=Sing	_	_	_	_
2	to	to	ADP	IN	_	_	_	_	_
3	glucocorticoid	glucocorticoid	ADJ	JJ	Degree=Pos	_	_	_	_
4	therapy	therapy	NOUN	NN	Number=Sing	_	_	_	_
5	has	have	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
6	been	be	AUX	VBN	Tense=Past|VerbForm=Part	_	_	_	_
7	observed	observe	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
8	in	in	ADP	IN	_	_	_	_	_
9	patients	patient	NOUN	NNS	Number=Plur	_	_	_	_
10	with	with	ADP	IN	_	_	_	_	_
11	autoimmune	autoimmune	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
12	/	/	PUNCT	,	_	_	_	_	SpaceAfter=No
13	inflammatory	inflammatory	ADJ	JJ	Degree=Pos	_	_	_	_
14	diseases	diseasis	NOUN	NNS	Number=Plur	_	_	_	_
15	and	and	CCONJ	CC	_	_	_	_	_
16	may	may	AUX	MD	VerbForm=Fin	_	_	_	_
17	be	be	AUX	VB	VerbForm=Inf	_	_	_	_
18	related	related	ADJ	JJ	Degree=Pos	_	_	_	_
19	to	to	ADP	IN	_	_	_	_	_
20	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
21	inflammatory	inflammatory	ADJ	JJ	Degree=Pos	_	_	_	_
22	process	process	NOUN	NN	Number=Sing	_	_	_	_
23	itself	itself	PRON	PRP	Gender=Neut|Number=Sing|Person=3|PronType=Prs	_	_	_	SpaceAfter=No
24	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1864
# text = The aim of this study was to examine the ability of tumor necrosis factor alpha (TNFalpha, a proinflammatory cytokine) and interleukin (IL)-10 (an anti-inflammatory cytokine) to differentially regulate the sensitivity of human monocytes/macrophages to glucocorticoids.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	aim	aim	NOUN	NN	Number=Sing	_	_	_	_
3	of	of	ADP	IN	_	_	_	_	_
4	this	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
5	study	study	NOUN	NN	Number=Sing	_	_	_	_
6	was	be	VERB	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
7	to	to	PART	TO	_	_	_	_	_
8	examine	examine	VERB	VB	VerbForm=Inf	_	_	_	_
9	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
10	ability	ability	NOUN	NN	Number=Sing	_	_	_	_
11	of	of	ADP	IN	_	_	_	_	_
12	tumor	tumor	NOUN	NN	Number=Sing	_	_	_	_
13	necrosis	necrosis	NOUN	NN	Number=Sing	_	_	_	_
14	factor	factor	NOUN	NN	Number=Sing	_	_	_	_
15	alpha	alpha	NOUN	NN	Number=Sing	_	_	_	_
16	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
17	TNFalpha	TNFalpha	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
18	,	,	PUNCT	,	_	_	_	_	_
19	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
20	proinflammatory	proinflammatory	ADJ	JJ	Degree=Pos	_	_	_	_
21	cytokine	cytokine	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
22	)	)	PUNCT	-RRB-	_	_	_	_	_
23	and	and	CCONJ	CC	_	_	_	_	_
24	interleukin	interleukin	NOUN	NN	Number=Sing	_	_	_	_
25	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
26	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
27	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
28	-	-	SYM	SYM	_	_	_	_	SpaceAfter=No
29	10	10	NUM	CD	NumType=Card	_	_	_	_
30	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
31	an	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
32	anti-inflammatory	anti-inflammatory	ADJ	JJ	Degree=Pos	_	_	_	_
33	cytokine	cytokine	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
34	)	)	PUNCT	-RRB-	_	_	_	_	_
35	to	to	PART	TO	_	_	_	_	_
36	differentially	differentially	ADV	RB	_	_	_	_	_
37	regulate	regulate	VERB	VB	VerbForm=Inf	_	_	_	_
38	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
39	sensitivity	sensitivity	NOUN	NN	Number=Sing	_	_	_	_
40	of	of	ADP	IN	_	_	_	_	_
41	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
42	monocytes	monocyte	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
43	/	/	PUNCT	,	_	_	_	_	SpaceAfter=No
44	macrophages	macrophage	NOUN	NNS	Number=Plur	_	_	_	_
45	to	to	ADP	IN	_	_	_	_	_
46	glucocorticoids	glucocorticoid	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
47	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1865
# text = To accomplish this, we first analyzed the pattern of TNFalpha and IL-10 inhibition by dexamethasone in LPS-stimulated whole-blood cell cultures.
1	To	to	PART	TO	_	_	_	_	_
2	accomplish	accomplish	VERB	VB	VerbForm=Inf	_	_	_	_
3	this	this	PRON	DT	Number=Sing|PronType=Dem	_	_	_	SpaceAfter=No
4	,	,	PUNCT	,	_	_	_	_	_
5	we	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
6	first	first	ADV	RB	_	_	_	_	_
7	analyzed	analyze	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
8	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
9	pattern	pattern	NOUN	NN	Number=Sing	_	_	_	_
10	of	of	ADP	IN	_	_	_	_	_
11	TNFalpha	TNFalpha	PROPN	NNP	Number=Sing	_	_	_	_
12	and	and	CCONJ	CC	_	_	_	_	_
13	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
14	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
15	10	10	NUM	CD	NumType=Card	_	_	_	_
16	inhibition	inhibition	NOUN	NN	Number=Sing	_	_	_	_
17	by	by	ADP	IN	_	_	_	_	_
18	dexamethasone	dexamethasone	NOUN	NN	Number=Sing	_	_	_	_
19	in	in	ADP	IN	_	_	_	_	_
20	LPS	LPS	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
21	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
22	stimulated	stimulate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
23	whole	whole	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
24	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
25	blood	blood	NOUN	NN	Number=Sing	_	_	_	_
26	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
27	cultures	culture	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
28	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1866
# text = Second, we studied the modulation of the sensitivity of these cells to dexamethasone by preincubation with TNFalpha or IL-10 and measurement of LPS-stimulated IL-6 secretion.
1	Second	second	ADV	RB	_	_	_	_	SpaceAfter=No
2	,	,	PUNCT	,	_	_	_	_	_
3	we	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
4	studied	study	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
5	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
6	modulation	modulation	NOUN	NN	Number=Sing	_	_	_	_
7	of	of	ADP	IN	_	_	_	_	_
8	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
9	sensitivity	sensitivity	NOUN	NN	Number=Sing	_	_	_	_
10	of	of	ADP	IN	_	_	_	_	_
11	these	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
12	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
13	to	to	PART	TO	_	_	_	_	_
14	dexamethasone	dexamethasone	VERB	VB	VerbForm=Inf	_	_	_	_
15	by	by	ADP	IN	_	_	_	_	_
16	preincubation	preincubation	NOUN	NN	Number=Sing	_	_	_	_
17	with	with	ADP	IN	_	_	_	_	_
18	TNFalpha	TNFalpha	PROPN	NNP	Number=Sing	_	_	_	_
19	or	or	CCONJ	CC	_	_	_	_	_
20	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
21	-	-	SYM	SYM	_	_	_	_	SpaceAfter=No
22	10	10	NUM	CD	NumType=Card	_	_	_	_
23	and	and	CCONJ	CC	_	_	_	_	_
24	measurement	measurement	NOUN	NN	Number=Sing	_	_	_	_
25	of	of	ADP	IN	_	_	_	_	_
26	LPS	LPS	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
27	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
28	stimulated	stimulate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
29	IL	Il	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
30	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
31	6	6	NUM	CD	NumType=Card	_	_	_	_
32	secretion	secretion	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
33	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1867
# text = In addition, we evaluated the effect of dexamethasone on phorbolmyristate-acetate-stimulated IL-1 receptor antagonist secretion by the human monocytic cell line U937.
1	In	in	ADP	IN	_	_	_	_	_
2	addition	addition	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
3	,	,	PUNCT	,	_	_	_	_	_
4	we	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
5	evaluated	evaluate	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
6	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
7	effect	effect	NOUN	NN	Number=Sing	_	_	_	_
8	of	of	ADP	IN	_	_	_	_	_
9	dexamethasone	dexamethasone	NOUN	NN	Number=Sing	_	_	_	_
10	on	on	ADP	IN	_	_	_	_	_
11	phorbolmyristate-acetate-stimulated	phorbolmyristate-acetate-stimulate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
12	IL	Il	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
13	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
14	1	1	NUM	CD	NumType=Card	_	_	_	_
15	receptor	receptor	NOUN	NN	Number=Sing	_	_	_	_
16	antagonist	antagonist	NOUN	NN	Number=Sing	_	_	_	_
17	secretion	secretion	NOUN	NN	Number=Sing	_	_	_	_
18	by	by	ADP	IN	_	_	_	_	_
19	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
20	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
21	monocytic	monocytic	ADJ	JJ	Degree=Pos	_	_	_	_
22	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
23	line	line	NOUN	NN	Number=Sing	_	_	_	_
24	U937	U937	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
25	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1868
# text = Finally, we investigated whether the modulation of corticosensitivity in TNFalpha- and IL-10-pretreated U937 cells was related to a change of the glucocorticoid receptor concentration and affinity.
1	Finally	finally	ADV	RB	_	_	_	_	SpaceAfter=No
2	,	,	PUNCT	,	_	_	_	_	_
3	we	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
4	investigated	investigate	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
5	whether	whether	SCONJ	IN	_	_	_	_	_
6	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
7	modulation	modulation	NOUN	NN	Number=Sing	_	_	_	_
8	of	of	ADP	IN	_	_	_	_	_
9	corticosensitivity	corticosensitivity	NOUN	NN	Number=Sing	_	_	_	_
10	in	in	ADP	IN	_	_	_	_	_
11	TNFalpha	TNFalpha	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
12	-	-	PUNCT	,	_	_	_	_	_
13	and	and	CCONJ	CC	_	_	_	_	_
14	IL	Il	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
15	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
16	10	10	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
17	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
18	pretreated	pretreate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
19	U937	U937	NUM	CD	NumType=Card	_	_	_	_
20	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
21	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
22	related	related	ADJ	JJ	Degree=Pos	_	_	_	_
23	to	to	ADP	IN	_	_	_	_	_
24	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
25	change	change	NOUN	NN	Number=Sing	_	_	_	_
26	of	of	ADP	IN	_	_	_	_	_
27	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
28	glucocorticoid	glucocorticoid	ADJ	JJ	Degree=Pos	_	_	_	_
29	receptor	receptor	NOUN	NN	Number=Sing	_	_	_	_
30	concentration	concentration	NOUN	NN	Number=Sing	_	_	_	_
31	and	and	CCONJ	CC	_	_	_	_	_
32	affinity	affinity	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
33	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1869
# text = Dexamethasone had different effects on LPS-induced TNFalpha and IL-10 secretion; whereas it suppressed TNFalpha in a dose-dependent fashion, its effect on IL-10 secretion was biphasic, producing stimulation at lower, and inhibition at higher doses.
1	Dexamethasone	Dexamethasone	PRON	NN	Number=Sing	_	_	_	_
2	had	have	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
3	different	different	ADJ	JJ	Degree=Pos	_	_	_	_
4	effects	effect	NOUN	NNS	Number=Plur	_	_	_	_
5	on	on	ADP	IN	_	_	_	_	_
6	LPS	LPS	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
7	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
8	induced	induced	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
9	TNFalpha	TNFalpha	PROPN	NNP	Number=Sing	_	_	_	_
10	and	and	CCONJ	CC	_	_	_	_	_
11	IL	Il	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
12	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
13	10	10	NUM	CD	NumType=Card	_	_	_	_
14	secretion	secretion	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
15	;	;	PUNCT	,	_	_	_	_	_
16	whereas	whereas	SCONJ	IN	_	_	_	_	_
17	it	it	PRON	PRP	Case=Nom|Gender=Neut|Number=Sing|Person=3|PronType=Prs	_	_	_	_
18	suppressed	suppress	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
19	TNFalpha	TNFalpha	PROPN	NNP	Number=Sing	_	_	_	_
20	in	in	ADP	IN	_	_	_	_	_
21	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
22	dose	dose	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
23	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
24	dependent	dependent	ADJ	JJ	Degree=Pos	_	_	_	_
25	fashion	fashion	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
26	,	,	PUNCT	,	_	_	_	_	_
27	it	it	PRON	PRP	Case=Nom|Gender=Neut|Number=Sing|Person=3|PronType=Prs	_	_	_	SpaceAfter=No
28	s	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
29	effect	effect	NOUN	NN	Number=Sing	_	_	_	_
30	on	on	ADP	IN	_	_	_	_	_
31	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
32	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
33	10	10	NUM	CD	NumType=Card	_	_	_	_
34	secretion	secretion	NOUN	NN	Number=Sing	_	_	_	_
35	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
36	biphasic	biphasic	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
37	,	,	PUNCT	,	_	_	_	_	_
38	producing	produce	VERB	VBG	VerbForm=Ger	_	_	_	_
39	stimulation	stimulation	NOUN	NN	Number=Sing	_	_	_	_
40	at	at	ADP	IN	_	_	_	_	_
41	lower	lower	ADJ	JJR	Degree=Cmp	_	_	_	SpaceAfter=No
42	,	,	PUNCT	,	_	_	_	_	_
43	and	and	CCONJ	CC	_	_	_	_	_
44	inhibition	inhibition	NOUN	NN	Number=Sing	_	_	_	_
45	at	at	ADP	IN	_	_	_	_	_
46	higher	higher	ADJ	JJR	Degree=Cmp	_	_	_	_
47	doses	dos	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
48	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1870
# text = The concentration of LPS employed influenced the effect of dexamethasone on IL-10 secretion (P < 0.001).
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	concentration	concentration	NOUN	NN	Number=Sing	_	_	_	_
3	of	of	ADP	IN	_	_	_	_	_
4	LPS	LPS	PROPN	NNP	Number=Sing	_	_	_	_
5	employed	employ	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
6	influenced	influence	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
7	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
8	effect	effect	NOUN	NN	Number=Sing	_	_	_	_
9	of	of	ADP	IN	_	_	_	_	_
10	dexamethasone	dexamethasone	NOUN	NN	Number=Sing	_	_	_	_
11	on	on	ADP	IN	_	_	_	_	_
12	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
13	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
14	10	10	NUM	CD	NumType=Card	_	_	_	_
15	secretion	secretion	NOUN	NN	Number=Sing	_	_	_	_
16	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
17	P	p	NOUN	NN	Number=Sing	_	_	_	_
18	<	<	PUNCT	-LRB-	_	_	_	_	_
19	0.001	0.001	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
20	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
21	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1871
# text = Pretreatment with TNFalpha diminished, and with IL-10 improved, the ability of dexamethasone to suppress IL-6 secretion in whole-blood cell cultures (P < 0.01 for both) and to enhance IL-1 receptor antagonist secretion by U937 cells (P < 0.05 for both).
1	Pretreatment	Pretreatment	NOUN	NN	Number=Sing	_	_	_	_
2	with	with	ADP	IN	_	_	_	_	_
3	TNFalpha	TNFalpha	PROPN	NNP	Number=Sing	_	_	_	_
4	diminished	diminish	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	SpaceAfter=No
5	,	,	PUNCT	,	_	_	_	_	_
6	and	and	CCONJ	CC	_	_	_	_	_
7	with	with	ADP	IN	_	_	_	_	_
8	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
9	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
10	10	10	NUM	CD	NumType=Card	_	_	_	_
11	improved	improve	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	SpaceAfter=No
12	,	,	PUNCT	,	_	_	_	_	_
13	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
14	ability	ability	NOUN	NN	Number=Sing	_	_	_	_
15	of	of	ADP	IN	_	_	_	_	_
16	dexamethasone	dexamethasone	NOUN	NN	Number=Sing	_	_	_	_
17	to	to	PART	TO	_	_	_	_	_
18	suppress	suppress	VERB	VB	VerbForm=Inf	_	_	_	_
19	IL	Il	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
20	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
21	6	6	NUM	CD	NumType=Card	_	_	_	_
22	secretion	secretion	NOUN	NN	Number=Sing	_	_	_	_
23	in	in	ADP	IN	_	_	_	_	_
24	whole	whole	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
25	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
26	blood	blood	NOUN	NN	Number=Sing	_	_	_	_
27	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
28	cultures	culture	NOUN	NNS	Number=Plur	_	_	_	_
29	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
30	P	p	NOUN	NN	Number=Sing	_	_	_	_
31	<	<	PUNCT	-LRB-	_	_	_	_	_
32	0.01	0.01	NUM	CD	NumType=Card	_	_	_	_
33	for	for	ADP	IN	_	_	_	_	_
34	both	both	CCONJ	CC	_	_	_	_	SpaceAfter=No
35	)	)	PUNCT	-RRB-	_	_	_	_	_
36	and	and	CCONJ	CC	_	_	_	_	_
37	to	to	PART	TO	_	_	_	_	_
38	enhance	enhance	VERB	VB	VerbForm=Inf	_	_	_	_
39	IL	Il	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
40	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
41	1	1	NUM	CD	NumType=Card	_	_	_	_
42	receptor	receptor	NOUN	NN	Number=Sing	_	_	_	_
43	antagonist	antagonist	NOUN	NN	Number=Sing	_	_	_	_
44	secretion	secretion	NOUN	NN	Number=Sing	_	_	_	_
45	by	by	ADP	IN	_	_	_	_	_
46	U937	U937	NUM	CD	NumType=Card	_	_	_	_
47	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
48	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
49	P	p	NOUN	NN	Number=Sing	_	_	_	_
50	<	<	PUNCT	-LRB-	_	_	_	_	_
51	0.05	0.05	NUM	CD	NumType=Card	_	_	_	_
52	for	for	ADP	IN	_	_	_	_	_
53	both	both	DET	DT	_	_	_	_	SpaceAfter=No
54	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
55	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1872
# text = TNFalpha decreased (P < 0.001), while IL-10 increased (P < 0.001), the concentration of dexamethasone binding sites in these cells, with no discernible effect on their binding affinity.
1	TNFalpha	TNFalpha	PROPN	NNP	Number=Sing	_	_	_	_
2	decreased	decreased	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
3	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
4	P	p	NOUN	NN	Number=Sing	_	_	_	_
5	<	<	PUNCT	-LRB-	_	_	_	_	_
6	0.001	0.001	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
7	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
8	,	,	PUNCT	,	_	_	_	_	_
9	while	while	SCONJ	IN	_	_	_	_	_
10	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
11	-	-	SYM	SYM	_	_	_	_	SpaceAfter=No
12	10	10	NUM	CD	NumType=Card	_	_	_	_
13	increased	increased	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
14	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
15	P	p	NOUN	NN	Number=Sing	_	_	_	_
16	<	<	PUNCT	-LRB-	_	_	_	_	_
17	0.001	0.001	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
18	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
19	,	,	PUNCT	,	_	_	_	_	_
20	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
21	concentration	concentration	NOUN	NN	Number=Sing	_	_	_	_
22	of	of	ADP	IN	_	_	_	_	_
23	dexamethasone	dexamethasone	NOUN	NN	Number=Sing	_	_	_	_
24	binding	bind	VERB	VBG	VerbForm=Ger	_	_	_	_
25	sites	site	NOUN	NNS	Number=Plur	_	_	_	_
26	in	in	ADP	IN	_	_	_	_	_
27	these	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
28	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
29	,	,	PUNCT	,	_	_	_	_	_
30	with	with	ADP	IN	_	_	_	_	_
31	no	no	DET	DT	_	_	_	_	_
32	discernible	discernible	ADJ	JJ	Degree=Pos	_	_	_	_
33	effect	effect	NOUN	NN	Number=Sing	_	_	_	_
34	on	on	ADP	IN	_	_	_	_	_
35	their	they	PRON	PRP$	Number=Plur|Person=3|Poss=Yes|PronType=Prs	_	_	_	_
36	binding	binding	NOUN	NN	Number=Sing	_	_	_	_
37	affinity	affinity	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
38	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1873
# text = We conclude that glucocorticoids differentially modulate TNFalpha and IL-10 secretion by human monocytes in a LPS dose-dependent fashion and that the sensitivity of these cells to glucocorticoids is altered by TNFalpha or IL-10 pretreatment; TNFalpha blocks their effects, whereas IL-10 acts synergistically with glucocorticoids.
1	We	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
2	conclude	conclude	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
3	that	that	SCONJ	IN	_	_	_	_	_
4	glucocorticoids	glucocorticoid	NOUN	NNS	Number=Plur	_	_	_	_
5	differentially	differentially	ADV	RB	_	_	_	_	_
6	modulate	modulate	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
7	TNFalpha	TNFalpha	PROPN	NNP	Number=Sing	_	_	_	_
8	and	and	CCONJ	CC	_	_	_	_	_
9	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
10	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
11	10	10	NUM	CD	NumType=Card	_	_	_	_
12	secretion	secretion	NOUN	NN	Number=Sing	_	_	_	_
13	by	by	ADP	IN	_	_	_	_	_
14	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
15	monocytes	monocyte	NOUN	NNS	Number=Plur	_	_	_	_
16	in	in	ADP	IN	_	_	_	_	_
17	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
18	LPS	LPS	PROPN	NNP	Number=Sing	_	_	_	_
19	dose	dose	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
20	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
21	dependent	dependent	ADJ	JJ	Degree=Pos	_	_	_	_
22	fashion	fashion	NOUN	NN	Number=Sing	_	_	_	_
23	and	and	CCONJ	CC	_	_	_	_	_
24	that	that	SCONJ	IN	_	_	_	_	_
25	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
26	sensitivity	sensitivity	NOUN	NN	Number=Sing	_	_	_	_
27	of	of	ADP	IN	_	_	_	_	_
28	these	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
29	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
30	to	to	ADP	IN	_	_	_	_	_
31	glucocorticoids	glucocorticoid	NOUN	NNS	Number=Plur	_	_	_	_
32	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
33	altered	alter	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
34	by	by	ADP	IN	_	_	_	_	_
35	TNFalpha	TNFalpha	PROPN	NNP	Number=Sing	_	_	_	_
36	or	or	CCONJ	CC	_	_	_	_	_
37	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
38	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
39	10	10	NUM	CD	NumType=Card	_	_	_	_
40	pretreatment	pretreatment	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
41	;	;	PUNCT	,	_	_	_	_	_
42	TNFalpha	TNFalpha	PROPN	NNP	Number=Sing	_	_	_	_
43	blocks	block	NOUN	NNS	Number=Plur	_	_	_	_
44	their	they	PRON	PRP$	Number=Plur|Person=3|Poss=Yes|PronType=Prs	_	_	_	_
45	effects	effect	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
46	,	,	PUNCT	,	_	_	_	_	_
47	whereas	whereas	SCONJ	IN	_	_	_	_	_
48	IL	Il	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
49	-	-	SYM	SYM	_	_	_	_	SpaceAfter=No
50	10	10	NUM	CD	NumType=Card	_	_	_	_
51	acts	acts	NOUN	NNS	Number=Plur	_	_	_	_
52	synergistically	synergistically	ADV	RB	_	_	_	_	_
53	with	with	ADP	IN	_	_	_	_	_
54	glucocorticoids	glucocorticoid	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
55	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1874
# text = This is accompanied by opposite glucocorticoid receptor changes, respectively opposing and favoring glucocorticoid actions.
1	This	this	PRON	DT	Number=Sing|PronType=Dem	_	_	_	_
2	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
3	accompanied	accompany	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
4	by	by	ADP	IN	_	_	_	_	_
5	opposite	opposite	ADJ	JJ	Degree=Pos	_	_	_	_
6	glucocorticoid	glucocorticoid	ADJ	JJ	Degree=Pos	_	_	_	_
7	receptor	receptor	NOUN	NN	Number=Sing	_	_	_	_
8	changes	change	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
9	,	,	PUNCT	,	_	_	_	_	_
10	respectively	respectively	ADV	RB	_	_	_	_	_
11	opposing	oppos	VERB	VBG	VerbForm=Ger	_	_	_	_
12	and	and	CCONJ	CC	_	_	_	_	_
13	favoring	favor	VERB	VBG	VerbForm=Ger	_	_	_	_
14	glucocorticoid	glucocorticoid	ADJ	JJ	Degree=Pos	_	_	_	_
15	actions	action	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
16	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1875
# text = This study suggests that the pattern of pro-/antiinflammatory cytokine secretion may alter the response of patients to glucocorticoid therapy.
1	This	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
2	study	study	NOUN	NN	Number=Sing	_	_	_	_
3	suggests	suggest	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
4	that	that	SCONJ	IN	_	_	_	_	_
5	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
6	pattern	pattern	NOUN	NN	Number=Sing	_	_	_	_
7	of	of	ADP	IN	_	_	_	_	_
8	pro-/	pro-ith	ADP	IN	Abbr=Yes	_	_	_	SpaceAfter=No
9	antiinflammatory	antiinflammatory	ADJ	JJ	Degree=Pos	_	_	_	_
10	cytokine	cytokine	NOUN	NN	Number=Sing	_	_	_	_
11	secretion	secretion	NOUN	NN	Number=Sing	_	_	_	_
12	may	may	AUX	MD	VerbForm=Fin	_	_	_	_
13	alter	alter	VERB	VB	VerbForm=Inf	_	_	_	_
14	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
15	response	response	NOUN	NN	Number=Sing	_	_	_	_
16	of	of	ADP	IN	_	_	_	_	_
17	patients	patient	NOUN	NNS	Number=Plur	_	_	_	_
18	to	to	PART	TO	_	_	_	_	_
19	glucocorticoid	glucocorticoid	VERB	VB	VerbForm=Inf	_	_	_	_
20	therapy	therapy	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
21	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 1876
# text = Document 00300379 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	00300379	00300379	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 1877
# text = CD14-mediated signal pathway of Porphyromonas gingivalis lipopolysaccharide in human gingival fibroblasts.
1	CD14	CD14	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
2	-mediated	-mediate	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
3	signal	signal	ADJ	JJ	Degree=Pos	_	_	_	_
4	pathway	pathway	NOUN	NN	Number=Sing	_	_	_	_
5	of	of	ADP	IN	_	_	_	_	_
6	Porphyromonas	Porphyromonas	PROPN	NNP	Number=Sing	_	_	_	_
7	gingivalis	gingivalis	PROPN	NNP	Number=Sing	_	_	_	_
8	lipopolysaccharide	lipopolysaccharide	NOUN	NN	Number=Sing	_	_	_	_
9	in	in	ADP	IN	_	_	_	_	_
10	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
11	gingival	gingival	NOUN	NN	Number=Sing	_	_	_	_
12	fibroblasts	fibroblast	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
13	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 1878
# text = Lipopolysaccharide (LPS) induces expression of inflammatory cytokines in monocytes/macrophages via CD14, one of the LPS receptors, which is expressed predominantly in these cells.
1	Lipopolysaccharide	Lipopolysaccharide	PROPN	NNP	Number=Sing	_	_	_	_
2	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
3	LPS	LPS	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
4	)	)	PUNCT	-RRB-	_	_	_	_	_
5	induces	induce	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
6	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
7	of	of	ADP	IN	_	_	_	_	_
8	inflammatory	inflammatory	ADJ	JJ	Degree=Pos	_	_	_	_
9	cytokines	cytokine	NOUN	NNS	Number=Plur	_	_	_	_
10	in	in	ADP	IN	_	_	_	_	_
11	monocytes	monocyte	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
12	/	/	PUNCT	,	_	_	_	_	SpaceAfter=No
13	macrophages	macrophage	NOUN	NNS	Number=Plur	_	_	_	_
14	via	via	ADP	IN	_	_	_	_	_
15	CD14	CD14	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
16	,	,	PUNCT	,	_	_	_	_	_
17	one	one	NUM	CD	NumType=Card	_	_	_	_
18	of	of	ADP	IN	_	_	_	_	_
19	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
20	LPS	Lp	NOUN	NNS	Number=Plur	_	_	_	_
21	receptors	receptor	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
22	,	,	PUNCT	,	_	_	_	_	_
23	which	which	PRON	WDT	PronType=Rel	_	_	_	_
24	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
25	expressed	express	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
26	predominantly	predominantly	ADV	RB	_	_	_	_	_
27	in	in	ADP	IN	_	_	_	_	_
28	these	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
29	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
30	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1879
# text = It has been demonstrated that Porphyromonas gingivalis LPS (P-LPS) also is able to induce inflammatory cytokines in human gingival fibroblasts.
1	It	it	PRON	PRP	Case=Nom|Gender=Neut|Number=Sing|Person=3|PronType=Prs	_	_	_	_
2	has	have	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
3	been	be	AUX	VBN	Tense=Past|VerbForm=Part	_	_	_	_
4	demonstrated	demonstrate	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
5	that	that	SCONJ	IN	_	_	_	_	_
6	Porphyromonas	Porphyromonas	PROPN	NNP	Number=Sing	_	_	_	_
7	gingivalis	gingivalis	PROPN	NNP	Number=Sing	_	_	_	_
8	LPS	LPS	PROPN	NNP	Number=Sing	_	_	_	_
9	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
10	P	p	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
11	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
12	LPS	Lps	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
13	)	)	PUNCT	-RRB-	_	_	_	_	_
14	also	also	ADV	RB	_	_	_	_	_
15	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
16	able	able	ADJ	JJ	Degree=Pos	_	_	_	_
17	to	to	PART	TO	_	_	_	_	_
18	induce	induce	VERB	VB	VerbForm=Inf	_	_	_	_
19	inflammatory	inflammatory	ADJ	JJ	Degree=Pos	_	_	_	_
20	cytokines	cytokine	NOUN	NNS	Number=Plur	_	_	_	_
21	in	in	ADP	IN	_	_	_	_	_
22	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
23	gingival	gingival	NOUN	NN	Number=Sing	_	_	_	_
24	fibroblasts	fibroblast	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
25	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1880
# text = Therefore, it is important to determine whether CD14 is expressed in gingival fibroblasts and to define the P-LPS-mediated signal-transducing mechanism in the cells.
1	Therefore	therefore	ADV	RB	_	_	_	_	SpaceAfter=No
2	,	,	PUNCT	,	_	_	_	_	_
3	it	it	PRON	PRP	Case=Nom|Gender=Neut|Number=Sing|Person=3|PronType=Prs	_	_	_	_
4	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
5	important	important	ADJ	JJ	Degree=Pos	_	_	_	_
6	to	to	PART	TO	_	_	_	_	_
7	determine	determine	VERB	VB	VerbForm=Inf	_	_	_	_
8	whether	whether	SCONJ	IN	_	_	_	_	_
9	CD14	CD14	PROPN	NNP	Number=Sing	_	_	_	_
10	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
11	expressed	express	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
12	in	in	ADP	IN	_	_	_	_	_
13	gingival	gingival	ADJ	JJ	Degree=Pos	_	_	_	_
14	fibroblasts	fibroblast	NOUN	NNS	Number=Plur	_	_	_	_
15	and	and	CCONJ	CC	_	_	_	_	_
16	to	to	PART	TO	_	_	_	_	_
17	define	define	VERB	VB	VerbForm=Inf	_	_	_	_
18	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
19	P	p	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
20	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
21	LPS	Lps	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
22	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
23	mediated	mediate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
24	signal	signal	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
25	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
26	transducing	transducing	NOUN	NN	Number=Sing	_	_	_	_
27	mechanism	mechanism	NOUN	NN	Number=Sing	_	_	_	_
28	in	in	ADP	IN	_	_	_	_	_
29	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
30	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
31	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1881
# text = In this study, we observed unexpectedly by immunohistochemical, Western blotting (immunoblotting), and Northern (RNA) blotting assays that CD14 is expressed at high density in human gingival fibroblasts.
1	In	in	ADP	IN	_	_	_	_	_
2	this	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
3	study	study	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
4	,	,	PUNCT	,	_	_	_	_	_
5	we	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
6	observed	observe	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
7	unexpectedly	unexpectedly	ADV	RB	_	_	_	_	_
8	by	by	ADP	IN	_	_	_	_	_
9	immunohistochemical	immunohistochemical	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
10	,	,	PUNCT	,	_	_	_	_	_
11	Western	western	ADJ	JJ	Degree=Pos	_	_	_	_
12	blotting	blotting	NOUN	NN	Number=Sing	_	_	_	_
13	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
14	immunoblotting	immunoblott	VERB	VBG	VerbForm=Ger	_	_	_	SpaceAfter=No
15	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
16	,	,	PUNCT	,	_	_	_	_	_
17	and	and	CCONJ	CC	_	_	_	_	_
18	Northern	Northern	PROPN	NNP	Number=Sing	_	_	_	_
19	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
20	RNA	RNA	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
21	)	)	PUNCT	-RRB-	_	_	_	_	_
22	blotting	blott	VERB	VBG	VerbForm=Ger	_	_	_	_
23	assays	assay	NOUN	NNS	Number=Plur	_	_	_	_
24	that	that	PRON	WDT	PronType=Rel	_	_	_	_
25	CD	CD	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
26	14	14	NUM	CD	NumType=Card	_	_	_	_
27	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
28	expressed	express	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
29	at	at	ADP	IN	_	_	_	_	_
30	high	high	ADJ	JJ	Degree=Pos	_	_	_	_
31	density	density	NOUN	NN	Number=Sing	_	_	_	_
32	in	in	ADP	IN	_	_	_	_	_
33	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
34	gingival	gingival	NOUN	NN	Number=Sing	_	_	_	_
35	fibroblasts	fibroblast	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
36	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1882
# text = P-LPS-induced expression of the monocyte chemoattractant protein 1 (MCP-1) gene in the cells was inhibited markedly by treatment with anti-human CD14 antibody and was completely inhibited by herbimycin A, a potent inhibitor of tyrosine kinase.
1	P-	P-	PUNCT	NFP	_	_	_	_	SpaceAfter=No
2	LPS	LPS	X	GW	_	_	_	_	SpaceAfter=No
3	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
4	induced	induce	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
5	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
6	of	of	ADP	IN	_	_	_	_	_
7	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
8	monocyte	monocyte	NOUN	NN	Number=Sing	_	_	_	_
9	chemoattractant	chemoattractant	NOUN	NN	Number=Sing	_	_	_	_
10	protein	protein	NOUN	NN	Number=Sing	_	_	_	_
11	1	1	NUM	CD	NumType=Card	_	_	_	_
12	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
13	MCP	Mcp	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
14	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
15	1	1	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
16	)	)	PUNCT	-RRB-	_	_	_	_	_
17	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
18	in	in	ADP	IN	_	_	_	_	_
19	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
20	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
21	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
22	inhibited	inhibit	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
23	markedly	markedly	ADV	RB	_	_	_	_	_
24	by	by	ADP	IN	_	_	_	_	_
25	treatment	treatment	NOUN	NN	Number=Sing	_	_	_	_
26	with	with	ADP	IN	_	_	_	_	_
27	anti-human	anti-human	ADJ	JJ	Degree=Pos	_	_	_	_
28	CD	CD	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
29	14	14	NUM	CD	NumType=Card	_	_	_	_
30	antibody	antibody	NOUN	NN	Number=Sing	_	_	_	_
31	and	and	CCONJ	CC	_	_	_	_	_
32	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
33	completely	completely	ADV	RB	_	_	_	_	_
34	inhibited	inhibit	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
35	by	by	ADP	IN	_	_	_	_	_
36	herbimycin	herbimycin	NOUN	NN	Number=Sing	_	_	_	_
37	A	a	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
38	,	,	PUNCT	,	_	_	_	_	_
39	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
40	potent	potent	NOUN	NN	Number=Sing	_	_	_	_
41	inhibitor	inhibitor	NOUN	NN	Number=Sing	_	_	_	_
42	of	of	ADP	IN	_	_	_	_	_
43	tyrosine	tyrosine	NOUN	NN	Number=Sing	_	_	_	_
44	kinase	kinase	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
45	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1883
# text = The inhibitor also dramatically inhibited monocyte chemotactic activity of and MCP-1 production by the cells.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	inhibitor	inhibitor	NOUN	NN	Number=Sing	_	_	_	_
3	also	also	ADV	RB	_	_	_	_	_
4	dramatically	dramatically	ADV	RB	_	_	_	_	_
5	inhibited	inhibit	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
6	monocyte	monocyte	NOUN	NN	Number=Sing	_	_	_	_
7	chemotactic	chemotactic	ADJ	JJ	Degree=Pos	_	_	_	_
8	activity	activity	NOUN	NN	Number=Sing	_	_	_	_
9	of	of	ADP	IN	_	_	_	_	_
10	and	and	CCONJ	CC	_	_	_	_	_
11	MCP	MCP	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
12	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
13	1	1	NUM	CD	NumType=Card	_	_	_	_
14	production	production	NOUN	NN	Number=Sing	_	_	_	_
15	by	by	ADP	IN	_	_	_	_	_
16	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
17	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
18	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1884
# text = Furthermore, P-LPS-induced expression of the MCP-1 gene in the cells also was blocked by inhibitors of two transcription factors, i.e., curcumin, an inhibitor of AP-1, and pyrolidine dithiocarbamate, an inhibitor of NF-kappaB.
1	Furthermore	furthermore	ADV	RB	_	_	_	_	SpaceAfter=No
2	,	,	PUNCT	,	_	_	_	_	_
3	P-	P-	X	GW	_	_	_	_	SpaceAfter=No
4	LPS	LPS	X	GW	_	_	_	_	SpaceAfter=No
5	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
6	induced	induce	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
7	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
8	of	of	ADP	IN	_	_	_	_	_
9	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
10	MCP	Mcp	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
11	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
12	1	1	NUM	CD	NumType=Card	_	_	_	_
13	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
14	in	in	ADP	IN	_	_	_	_	_
15	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
16	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
17	also	also	ADV	RB	_	_	_	_	_
18	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
19	blocked	block	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
20	by	by	ADP	IN	_	_	_	_	_
21	inhibitors	inhibitor	NOUN	NNS	Number=Plur	_	_	_	_
22	of	of	ADP	IN	_	_	_	_	_
23	two	two	NUM	CD	NumType=Card	_	_	_	_
24	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
25	factors	factor	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
26	,	,	PUNCT	,	_	_	_	_	_
27	i.e.	i.e.	X	FW	_	_	_	_	SpaceAfter=No
28	,	,	PUNCT	,	_	_	_	_	_
29	curcumin	curcumin	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
30	,	,	PUNCT	,	_	_	_	_	_
31	an	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
32	inhibitor	inhibitor	NOUN	NN	Number=Sing	_	_	_	_
33	of	of	ADP	IN	_	_	_	_	_
34	AP	ap	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
35	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
36	1	1	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
37	,	,	PUNCT	,	_	_	_	_	_
38	and	and	CCONJ	CC	_	_	_	_	_
39	pyrolidine	pyrolidine	NOUN	NN	Number=Sing	_	_	_	_
40	dithiocarbamate	dithiocarbamate	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
41	,	,	PUNCT	,	_	_	_	_	_
42	an	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
43	inhibitor	inhibitor	NOUN	NN	Number=Sing	_	_	_	_
44	of	of	ADP	IN	_	_	_	_	_
45	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
46	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
47	kappaB	kappaB	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
48	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1885
# text = Both inhibitors inhibited monocyte chemotactic activity in the culture supernatant of P-LPS-treated cells.
1	Both	both	DET	DT	_	_	_	_	_
2	inhibitors	inhibitor	NOUN	NNS	Number=Plur	_	_	_	_
3	inhibited	inhibit	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
4	monocyte	monocyte	NOUN	NN	Number=Sing	_	_	_	_
5	chemotactic	chemotactic	ADJ	JJ	Degree=Pos	_	_	_	_
6	activity	activity	NOUN	NN	Number=Sing	_	_	_	_
7	in	in	ADP	IN	_	_	_	_	_
8	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
9	culture	culture	NOUN	NN	Number=Sing	_	_	_	_
10	supernatant	supernatant	NOUN	NN	Number=Sing	_	_	_	_
11	of	of	ADP	IN	_	_	_	_	_
12	P-	P-	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
13	LPS	LPS	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
14	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
15	treated	treat	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
16	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
17	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1886
# text = Gel shift mobility assay showed stimulation of the AP-1 and NF-kappaB contents in P-LPS-treated cells.
1	Gel	gel	NOUN	NN	Number=Sing	_	_	_	_
2	shift	shift	NOUN	NN	Number=Sing	_	_	_	_
3	mobility	mobility	NOUN	NN	Number=Sing	_	_	_	_
4	assay	assay	NOUN	NN	Number=Sing	_	_	_	_
5	showed	show	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
6	stimulation	stimulation	NOUN	NN	Number=Sing	_	_	_	_
7	of	of	ADP	IN	_	_	_	_	_
8	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
9	AP	ap	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
10	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
11	1	1	NUM	CD	NumType=Card	_	_	_	_
12	and	and	CCONJ	CC	_	_	_	_	_
13	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
14	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
15	kappaB	kappaB	PROPN	NNP	Number=Sing	_	_	_	_
16	contents	contents	NOUN	NNS	Number=Plur	_	_	_	_
17	in	in	ADP	IN	_	_	_	_	_
18	P-	P-	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
19	LPS	LPS	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
20	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
21	treated	treat	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
22	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
23	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1887
# text = This study is the first to demonstrate the expression of CD14 in human gingival fibroblasts and to show that the signal-transducing pathway of P-LPS in the cells is mediated by CD14.
1	This	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
2	study	study	NOUN	NN	Number=Sing	_	_	_	_
3	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
4	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
5	first	first	ADJ	JJ	Degree=Pos|NumType=Ord	_	_	_	_
6	to	to	PART	TO	_	_	_	_	_
7	demonstrate	demonstrate	VERB	VB	VerbForm=Inf	_	_	_	_
8	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
9	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
10	of	of	ADP	IN	_	_	_	_	_
11	CD	CD	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
12	14	14	NUM	CD	NumType=Card	_	_	_	_
13	in	in	ADP	IN	_	_	_	_	_
14	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
15	gingival	gingival	NOUN	NN	Number=Sing	_	_	_	_
16	fibroblasts	fibroblast	NOUN	NNS	Number=Plur	_	_	_	_
17	and	and	CCONJ	CC	_	_	_	_	_
18	to	to	PART	TO	_	_	_	_	_
19	show	show	VERB	VB	VerbForm=Inf	_	_	_	_
20	that	that	SCONJ	IN	_	_	_	_	_
21	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
22	signal	signal	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
23	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
24	transducing	transduce	VERB	VBG	VerbForm=Ger	_	_	_	_
25	pathway	pathway	NOUN	NN	Number=Sing	_	_	_	_
26	of	of	ADP	IN	_	_	_	_	_
27	P	P	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
28	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
29	LPS	LPS	PROPN	NNP	Number=Sing	_	_	_	_
30	in	in	ADP	IN	_	_	_	_	_
31	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
32	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
33	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
34	mediated	mediate	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
35	by	by	ADP	IN	_	_	_	_	_
36	CD14	CD14	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
37	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 1888
# text = Document 00300384 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	00300384	00300384	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 1889
# text = UV-induced CYP1A1 gene expression in human cells is mediated by tryptophan.
1	UV	haUve	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
2	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
3	induced	induce	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
4	CYP1A1	Cyp1a1	NOUN	NN	Number=Sing	_	_	_	_
5	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
6	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
7	in	in	ADP	IN	_	_	_	_	_
8	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
9	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
10	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
11	mediated	mediate	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
12	by	by	ADP	IN	_	_	_	_	_
13	tryptophan	tryptophan	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
14	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 1890
# text = Induction of cytochrome P-4501A1 (CYP1A1) activity by UV has been observed earlier in animal studies via a mechanism that has not yet been resolved.
1	Induction	Induction	NOUN	NN	Number=Sing	_	_	_	_
2	of	of	ADP	IN	_	_	_	_	_
3	cytochrome	cytochrome	NOUN	NN	Number=Sing	_	_	_	_
4	P-4501A1	P-4501A1	NOUN	NN	Number=Sing	_	_	_	_
5	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
6	CYP1	CYP1	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
7	A1	A1	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
8	)	)	PUNCT	-RRB-	_	_	_	_	_
9	activity	activity	NOUN	NN	Number=Sing	_	_	_	_
10	by	by	ADP	IN	_	_	_	_	_
11	UV	UV	PROPN	NNP	Number=Sing	_	_	_	_
12	has	have	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
13	been	be	AUX	VBN	Tense=Past|VerbForm=Part	_	_	_	_
14	observed	observe	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
15	earlier	earlier	ADV	RBR	Degree=Cmp	_	_	_	_
16	in	in	ADP	IN	_	_	_	_	_
17	animal	animal	NOUN	NN	Number=Sing	_	_	_	_
18	studies	study	NOUN	NNS	Number=Plur	_	_	_	_
19	via	via	ADP	IN	_	_	_	_	_
20	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
21	mechanism	mechanism	NOUN	NN	Number=Sing	_	_	_	_
22	that	that	PRON	WDT	PronType=Rel	_	_	_	_
23	has	have	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
24	not	not	PART	RB	_	_	_	_	_
25	yet	yet	ADV	RB	_	_	_	_	_
26	been	be	AUX	VBN	Tense=Past|VerbForm=Part	_	_	_	_
27	resolved	resolve	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	SpaceAfter=No
28	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1891
# text = Our previous data have indicated that formylated indolocarbazoles which are formed by UV irradiation of tryptophan solutions are very potent
1	Our	we	PRON	PRP$	Number=Plur|Person=1|Poss=Yes|PronType=Prs	_	_	_	_
2	previous	previous	ADJ	JJ	Degree=Pos	_	_	_	_
3	data	data	NOUN	NN	Number=Sing	_	_	_	_
4	have	have	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
5	indicated	indicate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
6	that	that	SCONJ	IN	_	_	_	_	_
7	formylated	formylate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
8	indolocarbazoles	indolocarbazole	NOUN	NNS	Number=Plur	_	_	_	_
9	which	which	PRON	WDT	PronType=Rel	_	_	_	_
10	are	be	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
11	formed	form	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
12	by	by	ADP	IN	_	_	_	_	_
13	UV	UV	PROPN	NNP	Number=Sing	_	_	_	_
14	irradiation	irradiation	NOUN	NN	Number=Sing	_	_	_	_
15	of	of	ADP	IN	_	_	_	_	_
16	tryptophan	tryptophan	ADJ	JJ	Degree=Pos	_	_	_	_
17	solutions	solution	NOUN	NNS	Number=Plur	_	_	_	_
18	are	be	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
19	very	very	ADV	RB	_	_	_	_	_
20	potent	potent	ADJ	JJ	Degree=Pos	_	_	_	_

# sent_id = 1892
# text = Ah-receptor agonists.
1	Ah	ah	INTJ	UH	_	_	_	_	SpaceAfter=No
2	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
3	receptor	receptor	NOUN	NN	Number=Sing	_	_	_	_
4	agonists	agonist	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
5	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1893
# text = To evaluate the effect of UV light on cytochrome P4501A1 gene expression, we studied the induction of CYP1A1 mRNA by UV irradiation of cultured human keratinocytes (HaCaT cell line), primary human blood lymphocytes and mouse Hepa-1 cells.
1	To	to	PART	TO	_	_	_	_	_
2	evaluate	evaluate	VERB	VB	VerbForm=Inf	_	_	_	_
3	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
4	effect	effect	NOUN	NN	Number=Sing	_	_	_	_
5	of	of	ADP	IN	_	_	_	_	_
6	UV	UV	NOUN	NN	Number=Sing	_	_	_	_
7	light	light	NOUN	NN	Number=Sing	_	_	_	_
8	on	on	ADP	IN	_	_	_	_	_
9	cytochrome	cytochrome	NOUN	NN	Number=Sing	_	_	_	_
10	P4501A1	P4501A1	NOUN	NN	Number=Sing	_	_	_	_
11	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
12	expression	expression	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
13	,	,	PUNCT	,	_	_	_	_	_
14	we	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
15	studied	study	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
16	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
17	induction	induction	NOUN	NN	Number=Sing	_	_	_	_
18	of	of	ADP	IN	_	_	_	_	_
19	CYP1A1	CYP1A1	PROPN	NNP	Number=Sing	_	_	_	_
20	mRNA	mRNA	PROPN	NNP	Number=Sing	_	_	_	_
21	by	by	ADP	IN	_	_	_	_	_
22	UV	UV	PROPN	NNP	Number=Sing	_	_	_	_
23	irradiation	irradiation	NOUN	NN	Number=Sing	_	_	_	_
24	of	of	ADP	IN	_	_	_	_	_
25	cultured	culture	ADJ	JJ	Degree=Pos	_	_	_	_
26	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
27	keratinocytes	keratinocyte	NOUN	NNS	Number=Plur	_	_	_	_
28	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
29	HaCaT	Hacat	NOUN	NN	Number=Sing	_	_	_	_
30	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
31	line	line	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
32	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
33	,	,	PUNCT	,	_	_	_	_	_
34	primary	primary	ADJ	JJ	Degree=Pos	_	_	_	_
35	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
36	blood	blood	NOUN	NN	Number=Sing	_	_	_	_
37	lymphocytes	lymphocyte	NOUN	NNS	Number=Plur	_	_	_	_
38	and	and	CCONJ	CC	_	_	_	_	_
39	mouse	mouse	NOUN	NN	Number=Sing	_	_	_	_
40	Hepa	Hepa	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
41	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
42	1	1	NUM	CD	NumType=Card	_	_	_	_
43	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
44	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1894
# text = The cells were exposed to UV light delivered by a bank of 6 Philips TL20/12RS sun lamps emitting primarily in the UVB range in the absence and presence of tryptophan.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
3	were	be	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
4	exposed	expose	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
5	to	to	ADP	IN	_	_	_	_	_
6	UV	UV	PROPN	NNP	Number=Sing	_	_	_	_
7	light	light	NOUN	NN	Number=Sing	_	_	_	_
8	delivered	deliver	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
9	by	by	ADP	IN	_	_	_	_	_
10	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
11	bank	bank	NOUN	NN	Number=Sing	_	_	_	_
12	of	of	ADP	IN	_	_	_	_	_
13	6	6	NUM	CD	NumType=Card	_	_	_	_
14	Philips	Philips	PROPN	NNP	Number=Sing	_	_	_	_
15	TL20/12RS	tl20/12rs	PROPN	NNP	Number=Sing	_	_	_	_
16	sun	sun	NOUN	NN	Number=Sing	_	_	_	_
17	lamps	lamp	NOUN	NNS	Number=Plur	_	_	_	_
18	emitting	emit	VERB	VBG	VerbForm=Ger	_	_	_	_
19	primarily	primarily	ADV	RB	_	_	_	_	_
20	in	in	ADP	IN	_	_	_	_	_
21	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
22	UVB	uvb	PROPN	NNP	Number=Sing	_	_	_	_
23	range	range	NOUN	NN	Number=Sing	_	_	_	_
24	in	in	ADP	IN	_	_	_	_	_
25	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
26	absence	absence	NOUN	NN	Number=Sing	_	_	_	_
27	and	and	CCONJ	CC	_	_	_	_	_
28	presence	presence	NOUN	NN	Number=Sing	_	_	_	_
29	of	of	ADP	IN	_	_	_	_	_
30	tryptophan	tryptophan	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
31	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1895
# text = A semiquantitative reverse transcriptase-linked polymerase chain reaction (RT-PCR) was used for analysis of gene expression in the treated cells.
1	A	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
2	semiquantitative	semiquantitative	ADJ	JJ	Degree=Pos	_	_	_	_
3	reverse	reverse	NOUN	NN	Number=Sing	_	_	_	_
4	transcriptase	transcriptase	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
5	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
6	linked	link	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
7	polymerase	polymerase	NOUN	NN	Number=Sing	_	_	_	_
8	chain	chain	NOUN	NN	Number=Sing	_	_	_	_
9	reaction	reaction	NOUN	NN	Number=Sing	_	_	_	_
10	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
11	RT	Rt	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
12	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
13	PCR	Pcr	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
14	)	)	PUNCT	-RRB-	_	_	_	_	_
15	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
16	used	use	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
17	for	for	ADP	IN	_	_	_	_	_
18	analysis	analysis	NOUN	NN	Number=Sing	_	_	_	_
19	of	of	ADP	IN	_	_	_	_	_
20	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
21	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
22	in	in	ADP	IN	_	_	_	_	_
23	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
24	treated	treat	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
25	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
26	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1896
# text = The results show that the CYP1A1 mRNA level induced by UV in the presence of tryptophan was higher than that induced by UV alone in both HaCaT cells and lymphocytes after 3 h of incubation post-UV irradiation.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	results	result	NOUN	NNS	Number=Plur	_	_	_	_
3	show	show	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
4	that	that	SCONJ	IN	_	_	_	_	_
5	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
6	CYP1A1	CYP1A1	PROPN	NNP	Number=Sing	_	_	_	_
7	mRNA	mRNA	PROPN	NNP	Number=Sing	_	_	_	_
8	level	level	NOUN	NN	Number=Sing	_	_	_	_
9	induced	induce	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
10	by	by	ADP	IN	_	_	_	_	_
11	UV	UV	PROPN	NNP	Number=Sing	_	_	_	_
12	in	in	ADP	IN	_	_	_	_	_
13	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
14	presence	presence	NOUN	NN	Number=Sing	_	_	_	_
15	of	of	ADP	IN	_	_	_	_	_
16	tryptophan	tryptophan	NOUN	NN	Number=Sing	_	_	_	_
17	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
18	higher	higher	ADJ	JJR	Degree=Cmp	_	_	_	_
19	than	than	ADP	IN	_	_	_	_	_
20	that	that	PRON	DT	Number=Sing|PronType=Dem	_	_	_	_
21	induced	induce	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
22	by	by	ADP	IN	_	_	_	_	_
23	UV	UV	PROPN	NNP	Number=Sing	_	_	_	_
24	alone	alone	ADV	RB	_	_	_	_	_
25	in	in	ADP	IN	_	_	_	_	_
26	both	both	DET	DT	_	_	_	_	_
27	HaCaT	Hacat	ADJ	JJ	Degree=Pos	_	_	_	_
28	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
29	and	and	CCONJ	CC	_	_	_	_	_
30	lymphocytes	lymphocyte	NOUN	NNS	Number=Plur	_	_	_	_
31	after	after	ADP	IN	_	_	_	_	_
32	3	3	NUM	CD	NumType=Card	_	_	_	_
33	h	h	NOUN	NN	Number=Sing	_	_	_	_
34	of	of	ADP	IN	_	_	_	_	_
35	incubation	incubation	NOUN	NN	Number=Sing	_	_	_	_
36	post	post	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
37	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
38	UV	uv	NOUN	NN	Number=Sing	_	_	_	_
39	irradiation	irradiation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
40	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1897
# text = To find out if the induction by UV light is caused by the formation of an Ah receptor ligand, Hepa-1 wild-type and Ah receptor deficient c12 cell lines were applied.
1	To	to	PART	TO	_	_	_	_	_
2	find	find	VERB	VB	VerbForm=Inf	_	_	_	_
3	out	out	ADP	RP	_	_	_	_	_
4	if	if	SCONJ	IN	_	_	_	_	_
5	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
6	induction	induction	NOUN	NN	Number=Sing	_	_	_	_
7	by	by	ADP	IN	_	_	_	_	_
8	UV	UV	PROPN	NNP	Number=Sing	_	_	_	_
9	light	light	NOUN	NN	Number=Sing	_	_	_	_
10	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
11	caused	cause	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
12	by	by	ADP	IN	_	_	_	_	_
13	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
14	formation	formation	NOUN	NN	Number=Sing	_	_	_	_
15	of	of	ADP	IN	_	_	_	_	_
16	an	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
17	Ah	ah	PROPN	NNP	Number=Sing	_	_	_	_
18	receptor	receptor	NOUN	NN	Number=Sing	_	_	_	_
19	ligand	ligand	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
20	,	,	PUNCT	,	_	_	_	_	_
21	Hepa	Hepa	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
22	-1	-1	NUM	CD	NumType=Card	_	_	_	_
23	wild	wild	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
24	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
25	type	type	NOUN	NN	Number=Sing	_	_	_	_
26	and	and	CCONJ	CC	_	_	_	_	_
27	Ah	ah	PROPN	NNP	Number=Sing	_	_	_	_
28	receptor	receptor	NOUN	NN	Number=Sing	_	_	_	_
29	deficient	deficient	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
30	c12	c12	NUM	CD	NumType=Card	_	_	_	_
31	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
32	lines	line	NOUN	NNS	Number=Plur	_	_	_	_
33	were	be	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
34	applied	apply	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	SpaceAfter=No
35	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1898
# text = Wild-type (wt) cells were inducible either by the tryptophan photoproduct 6-formylindolo[3,2-b]carbazole (FICZ) or by UV-irradiation but very low or undetectable levels were observed in the c12 cells.
1	Wild	wild	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
2	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
3	type	type	NOUN	NN	Number=Sing	_	_	_	_
4	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
5	wt	wt	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
6	)	)	PUNCT	-RRB-	_	_	_	_	_
7	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
8	were	be	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
9	inducible	inducible	ADJ	JJ	Degree=Pos	_	_	_	_
10	either	either	CCONJ	CC	_	_	_	_	_
11	by	by	ADP	IN	_	_	_	_	_
12	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
13	tryptophan	tryptophan	ADJ	JJ	Degree=Pos	_	_	_	_
14	photoproduct	photoproduct	NOUN	NN	Number=Sing	_	_	_	_
15	6	6	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
16	-	-	PUNCT	:	_	_	_	_	SpaceAfter=No
17	formylindolo	formylindolo	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
18	[3	[3	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
19	,	,	PUNCT	,	_	_	_	_	SpaceAfter=No
20	2	2	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
21	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
22	b]	b]	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
23	carbazole	carbazole	NOUN	NN	Number=Sing	_	_	_	_
24	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
25	FICZ	FICZ	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
26	)	)	PUNCT	-RRB-	_	_	_	_	_
27	or	or	CCONJ	CC	_	_	_	_	_
28	by	by	ADP	IN	_	_	_	_	_
29	UV	UV	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
30	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
31	irradiation	irradiation	NOUN	NN	Number=Sing	_	_	_	_
32	but	but	CCONJ	CC	_	_	_	_	_
33	very	very	ADV	RB	_	_	_	_	_
34	low	low	ADJ	JJ	Degree=Pos	_	_	_	_
35	or	or	CCONJ	CC	_	_	_	_	_
36	undetectable	undetectable	ADJ	JJ	Degree=Pos	_	_	_	_
37	levels	level	NOUN	NNS	Number=Plur	_	_	_	_
38	were	be	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
39	observed	observe	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
40	in	in	ADP	IN	_	_	_	_	_
41	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
42	c12	c12	NOUN	NN	Number=Sing	_	_	_	_
43	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
44	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1899
# text = This shows that the induction of gene expression by FICZ and UV is Ah receptor dependent.
1	This	this	PRON	DT	Number=Sing|PronType=Dem	_	_	_	_
2	shows	show	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
3	that	that	SCONJ	IN	_	_	_	_	_
4	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
5	induction	induction	NOUN	NN	Number=Sing	_	_	_	_
6	of	of	ADP	IN	_	_	_	_	_
7	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
8	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
9	by	by	ADP	IN	_	_	_	_	_
10	FICZ	FICZ	PROPN	NNP	Number=Sing	_	_	_	_
11	and	and	CCONJ	CC	_	_	_	_	_
12	UV	UV	PROPN	NNP	Number=Sing	_	_	_	_
13	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
14	Ah	ah	PROPN	NNP	Number=Sing	_	_	_	_
15	receptor	receptor	NOUN	NN	Number=Sing	_	_	_	_
16	dependent	dependent	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
17	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1900
# text = Together, these results indicate that UV-induced CYP1A1 gene expression in mammalian cells is mediated by an Ah receptor ligand formed from tryptophan.
1	Together	together	ADV	RB	_	_	_	_	SpaceAfter=No
2	,	,	PUNCT	,	_	_	_	_	_
3	these	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
4	results	result	NOUN	NNS	Number=Plur	_	_	_	_
5	indicate	indicate	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
6	that	that	SCONJ	IN	_	_	_	_	_
7	UV	uv	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
8	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
9	induced	induce	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
10	CYP1A1	Cyp1a1	NOUN	NN	Number=Sing	_	_	_	_
11	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
12	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
13	in	in	ADP	IN	_	_	_	_	_
14	mammalian	mammalian	ADJ	JJ	Degree=Pos	_	_	_	_
15	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
16	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
17	mediated	mediate	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
18	by	by	ADP	IN	_	_	_	_	_
19	an	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
20	Ah	ah	PROPN	NNP	Number=Sing	_	_	_	_
21	receptor	receptor	NOUN	NN	Number=Sing	_	_	_	_
22	ligand	ligand	NOUN	NN	Number=Sing	_	_	_	_
23	formed	form	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
24	from	from	ADP	IN	_	_	_	_	_
25	tryptophan	tryptophan	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
26	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1901
# text = Thus, the photoproducts of tryptophan are suggested to be mediators of light via binding to the Ah receptor and as such also could have a role in light-regulated biological rhythms.
1	Thus	thus	ADV	RB	_	_	_	_	SpaceAfter=No
2	,	,	PUNCT	,	_	_	_	_	_
3	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
4	photoproducts	photoproduct	NOUN	NNS	Number=Plur	_	_	_	_
5	of	of	ADP	IN	_	_	_	_	_
6	tryptophan	tryptophan	NOUN	NN	Number=Sing	_	_	_	_
7	are	be	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
8	suggested	suggest	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
9	to	to	PART	TO	_	_	_	_	_
10	be	be	AUX	VB	VerbForm=Inf	_	_	_	_
11	mediators	mediator	NOUN	NNS	Number=Plur	_	_	_	_
12	of	of	ADP	IN	_	_	_	_	_
13	light	light	NOUN	NN	Number=Sing	_	_	_	_
14	via	via	NOUN	NN	Number=Sing	_	_	_	_
15	binding	binding	VERB	VBG	VerbForm=Ger	_	_	_	_
16	to	to	ADP	IN	_	_	_	_	_
17	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
18	Ah	ah	PROPN	NNP	Number=Sing	_	_	_	_
19	receptor	receptor	NOUN	NN	Number=Sing	_	_	_	_
20	and	and	CCONJ	CC	_	_	_	_	_
21	as	as	ADP	IN	_	_	_	_	_
22	such	such	ADJ	JJ	Degree=Pos	_	_	_	_
23	also	also	ADV	RB	_	_	_	_	_
24	could	could	AUX	MD	VerbForm=Fin	_	_	_	_
25	have	have	VERB	VB	VerbForm=Inf	_	_	_	_
26	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
27	role	role	NOUN	NN	Number=Sing	_	_	_	_
28	in	in	ADP	IN	_	_	_	_	_
29	light	light	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
30	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
31	regulated	regulate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
32	biological	biological	ADJ	JJ	Degree=Pos	_	_	_	_
33	rhythms	rhythm	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
34	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 1902
# text = Document 00300385 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	00300385	00300385	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 1903
# text = The Ah receptor recognizes DNA binding sites for the B cell transcription factor, BSAP: a possible mechanism for dioxin-mediated alteration of CD19 gene expression in human B lymphocytes.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	Ah	ah	PROPN	NNP	Number=Sing	_	_	_	_
3	receptor	receptor	NOUN	NN	Number=Sing	_	_	_	_
4	recognizes	recognize	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
5	DNA	dna	NOUN	NN	Number=Sing	_	_	_	_
6	binding	bind	VERB	VBG	VerbForm=Ger	_	_	_	_
7	sites	site	NOUN	NNS	Number=Plur	_	_	_	_
8	for	for	ADP	IN	_	_	_	_	_
9	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
10	B	b	ADJ	JJ	Degree=Pos	_	_	_	_
11	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
12	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
13	factor	factor	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
14	,	,	PUNCT	,	_	_	_	_	_
15	BSAP	Bsap	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
16	:	:	PUNCT	:	_	_	_	_	_
17	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
18	possible	possible	ADJ	JJ	Degree=Pos	_	_	_	_
19	mechanism	mechanism	NOUN	NN	Number=Sing	_	_	_	_
20	for	for	ADP	IN	_	_	_	_	_
21	dioxin-	dioxin-	SYM	NFP	_	_	_	_	SpaceAfter=No
22	mediated	mediate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
23	alteration	alteration	NOUN	NN	Number=Sing	_	_	_	_
24	of	of	ADP	IN	_	_	_	_	_
25	CD	cd	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
26	19	19	NUM	CD	NumType=Card	_	_	_	_
27	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
28	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
29	in	in	ADP	IN	_	_	_	_	_
30	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
31	B	b	NOUN	NN	Number=Sing	_	_	_	_
32	lymphocytes.	lymphocytes.	NOUN	NN	Number=Sing	_	_	_	SpacesAfter=\s\n

# sent_id = 1904
# text = 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) inhibits murine and human B lymphocyte immunoglobulin production through an unknown mechanism.
1	2,3,7,8-tetrachlorodibenzo-p-dioxin	2,3,7,8-tetrachlorodibenzo-p-dioxin	NOUN	NN	Number=Sing	_	_	_	_
2	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
3	TCDD	tCDd	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
4	)	)	PUNCT	-RRB-	_	_	_	_	_
5	inhibits	inhibit	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
6	murine	murine	NOUN	NN	Number=Sing	_	_	_	_
7	and	and	CCONJ	CC	_	_	_	_	_
8	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
9	B	b	NOUN	NN	Number=Sing	_	_	_	_
10	lymphocyte	lymphocyte	NOUN	NN	Number=Sing	_	_	_	_
11	immunoglobulin	immunoglobulin	ADP	IN	_	_	_	_	_
12	production	production	NOUN	NN	Number=Sing	_	_	_	_
13	through	through	ADP	IN	_	_	_	_	_
14	an	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
15	unknown	unknown	ADJ	JJ	Degree=Pos	_	_	_	_
16	mechanism	mechanism	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
17	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1905
# text = This study investigated the effect of TCDD on expression of the CD19 gene in a human B lymphocyte cell line.
1	This	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
2	study	study	NOUN	NN	Number=Sing	_	_	_	_
3	investigated	investigate	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
4	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
5	effect	effect	NOUN	NN	Number=Sing	_	_	_	_
6	of	of	ADP	IN	_	_	_	_	_
7	TCDD	tCDd	NOUN	NN	Number=Sing	_	_	_	_
8	on	on	ADP	IN	_	_	_	_	_
9	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
10	of	of	ADP	IN	_	_	_	_	_
11	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
12	CD	cd	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
13	19	19	NUM	CD	NumType=Card	_	_	_	_
14	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
15	in	in	ADP	IN	_	_	_	_	_
16	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
17	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
18	B	b	NOUN	NN	Number=Sing	_	_	_	_
19	lymphocyte	lymphocyte	NOUN	NN	Number=Sing	_	_	_	_
20	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
21	line	line	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
22	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1906
# text = Northern blot analysis showed that TCDD treatment decreased steady state levels of CD19 mRNA by 67% in the IM-9 cell line.
1	Northern	Northern	ADJ	JJ	Degree=Pos	_	_	_	_
2	blot	blot	NOUN	NN	Number=Sing	_	_	_	_
3	analysis	analysis	NOUN	NN	Number=Sing	_	_	_	_
4	showed	show	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
5	that	that	SCONJ	IN	_	_	_	_	_
6	TCDD	TCDD	PROPN	NNP	Number=Sing	_	_	_	_
7	treatment	treatment	NOUN	NN	Number=Sing	_	_	_	_
8	decreased	decrease	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
9	steady	steady	ADJ	JJ	Degree=Pos	_	_	_	_
10	state	state	NOUN	NN	Number=Sing	_	_	_	_
11	levels	level	NOUN	NNS	Number=Plur	_	_	_	_
12	of	of	ADP	IN	_	_	_	_	_
13	CD	cd	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
14	19	19	NUM	CD	NumType=Card	_	_	_	_
15	mRNA	mRNA	PROPN	NNP	Number=Sing	_	_	_	_
16	by	by	ADP	IN	_	_	_	_	_
17	67	67	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
18	%	%	SYM	NN	Number=Sing	_	_	_	_
19	in	in	ADP	IN	_	_	_	_	_
20	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
21	IM	Im	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
22	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
23	9	9	NUM	CD	NumType=Card	_	_	_	_
24	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
25	line	line	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
26	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1907
# text = Using a gel mobility shift assay, we identified a DNA-binding complex in IM-9 nuclear extracts that by several criteria appears to be the Ah receptor.
1	Using	use	VERB	VBG	VerbForm=Ger	_	_	_	_
2	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
3	gel	gel	NOUN	NN	Number=Sing	_	_	_	_
4	mobility	mobility	NOUN	NN	Number=Sing	_	_	_	_
5	shift	shift	NOUN	NN	Number=Sing	_	_	_	_
6	assay	assay	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
7	,	,	PUNCT	,	_	_	_	_	_
8	we	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
9	identified	identify	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
10	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
11	DNA	dna	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
12	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
13	binding	bind	VERB	VBG	VerbForm=Ger	_	_	_	_
14	complex	complex	NOUN	NN	Number=Sing	_	_	_	_
15	in	in	ADP	IN	_	_	_	_	_
16	IM	Im	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
17	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
18	9	9	NUM	CD	NumType=Card	_	_	_	_
19	nuclear	nuclear	ADJ	JJ	Degree=Pos	_	_	_	_
20	extracts	extract	NOUN	NNS	Number=Plur	_	_	_	_
21	that	that	PRON	WDT	PronType=Rel	_	_	_	_
22	by	by	ADP	IN	_	_	_	_	_
23	several	several	ADJ	JJ	Degree=Pos	_	_	_	_
24	criteria	criteria	NOUN	NN	Number=Sing	_	_	_	_
25	appears	appear	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
26	to	to	PART	TO	_	_	_	_	_
27	be	be	AUX	VB	VerbForm=Inf	_	_	_	_
28	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
29	Ah	ah	PROPN	NNP	Number=Sing	_	_	_	_
30	receptor	receptor	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
31	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1908
# text = In addition, the Ah receptor complex recognized a DNA binding site for B cell lineage-specific activator protein (BSAP) in the promoter region of the human CD19 gene which is similar to the consensus
1	In	in	ADP	IN	_	_	_	_	_
2	addition	addition	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
3	,	,	PUNCT	,	_	_	_	_	_
4	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
5	Ah	ah	PROPN	NNP	Number=Sing	_	_	_	_
6	receptor	receptor	NOUN	NN	Number=Sing	_	_	_	_
7	complex	complex	NOUN	NN	Number=Sing	_	_	_	_
8	recognized	recognize	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
9	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
10	DNA	dna	NOUN	NN	Number=Sing	_	_	_	_
11	binding	bind	VERB	VBG	VerbForm=Ger	_	_	_	_
12	site	site	NOUN	NN	Number=Sing	_	_	_	_
13	for	for	ADP	IN	_	_	_	_	_
14	B	b	ADJ	JJ	Degree=Pos	_	_	_	_
15	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
16	lineage	lineage	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
17	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
18	specific	specific	ADJ	JJ	Degree=Pos	_	_	_	_
19	activator	activator	NOUN	NN	Number=Sing	_	_	_	_
20	protein	protein	NOUN	NN	Number=Sing	_	_	_	_
21	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
22	BSAP	BSAP	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
23	)	)	PUNCT	-RRB-	_	_	_	_	_
24	in	in	ADP	IN	_	_	_	_	_
25	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
26	promoter	promoter	NOUN	NN	Number=Sing	_	_	_	_
27	region	region	NOUN	NN	Number=Sing	_	_	_	_
28	of	of	ADP	IN	_	_	_	_	_
29	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
30	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
31	CD	cd	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
32	19	19	NUM	CD	NumType=Card	_	_	_	_
33	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
34	which	which	PRON	WDT	PronType=Rel	_	_	_	_
35	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
36	similar	similar	ADJ	JJ	Degree=Pos	_	_	_	_
37	to	to	ADP	IN	_	_	_	_	_
38	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
39	consensus	consensus	NOUN	NN	Number=Sing	_	_	_	_

# sent_id = 1909
# text = Ah receptor DNA binding site.
1	Ah	ah	ADJ	JJ	Degree=Pos	_	_	_	_
2	receptor	receptor	NOUN	NN	Number=Sing	_	_	_	_
3	DNA	dna	NOUN	NN	Number=Sing	_	_	_	_
4	binding	binding	VERB	VBG	VerbForm=Ger	_	_	_	_
5	site	site	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
6	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1910
# text = These results suggest that the AhR could interfere with BSAP-stimulated CD19 gene transcription by competition for a common DNA binding site.
1	These	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
2	results	result	NOUN	NNS	Number=Plur	_	_	_	_
3	suggest	suggest	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
4	that	that	SCONJ	IN	_	_	_	_	_
5	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
6	AhR	Ahr	NOUN	NN	Number=Sing	_	_	_	_
7	could	could	AUX	MD	VerbForm=Fin	_	_	_	_
8	interfere	interfere	VERB	VB	VerbForm=Inf	_	_	_	_
9	with	with	ADP	IN	_	_	_	_	_
10	BSAP	BSAP	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
11	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
12	stimulated	stimulate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
13	CD	cd	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
14	19	19	NUM	CD	NumType=Card	_	_	_	_
15	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
16	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
17	by	by	ADP	IN	_	_	_	_	_
18	competition	competition	NOUN	NN	Number=Sing	_	_	_	_
19	for	for	ADP	IN	_	_	_	_	_
20	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
21	common	common	ADJ	JJ	Degree=Pos	_	_	_	_
22	DNA	dna	NOUN	NN	Number=Sing	_	_	_	_
23	binding	bind	VERB	VBG	VerbForm=Ger	_	_	_	_
24	site	site	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
25	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 1911
# text = Document 00300387 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	00300387	00300387	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 1912
# text = Apoptosis and growth inhibition in malignant lymphocytes after treatment with arsenic trioxide at clinically achievable concentrations [see comments] BACKGROUND: Arsenic trioxide (As2O3) can induce clinical remission in patients with acute promyelocytic leukemia via induction of differentiation and programmed cell death (apoptosis).
1	Apoptosis	Apoptosis	PROPN	NNP	Number=Sing	_	_	_	_
2	and	and	CCONJ	CC	_	_	_	_	_
3	growth	growth	NOUN	NN	Number=Sing	_	_	_	_
4	inhibition	inhibition	NOUN	NN	Number=Sing	_	_	_	_
5	in	in	ADP	IN	_	_	_	_	_
6	malignant	malignant	ADJ	JJ	Degree=Pos	_	_	_	_
7	lymphocytes	lymphocyte	NOUN	NNS	Number=Plur	_	_	_	_
8	after	after	ADP	IN	_	_	_	_	_
9	treatment	treatment	NOUN	NN	Number=Sing	_	_	_	_
10	with	with	ADP	IN	_	_	_	_	_
11	arsenic	arsenic	NOUN	NN	Number=Sing	_	_	_	_
12	trioxide	trioxide	NOUN	NN	Number=Sing	_	_	_	_
13	at	at	ADP	IN	_	_	_	_	_
14	clinically	clinically	ADV	RB	_	_	_	_	_
15	achievable	achievable	ADJ	JJ	Degree=Pos	_	_	_	_
16	concentrations	concentration	NOUN	NNS	Number=Plur	_	_	_	_
17	[	[	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
18	see	see	VERB	VB	Mood=Imp|VerbForm=Fin	_	_	_	_
19	comments	comment	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
20	]	]	PUNCT	-RRB-	_	_	_	_	SpacesAfter=\s\n
21	BACKGROUND	background	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
22	:	:	PUNCT	:	_	_	_	_	_
23	Arsenic	arsenic	ADJ	JJ	Degree=Pos	_	_	_	_
24	trioxide	trioxide	NOUN	NN	Number=Sing	_	_	_	_
25	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
26	As2	As2	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
27	O3	O3	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
28	)	)	PUNCT	-RRB-	_	_	_	_	_
29	can	can	AUX	MD	VerbForm=Fin	_	_	_	_
30	induce	induce	VERB	VB	VerbForm=Inf	_	_	_	_
31	clinical	clinical	ADJ	JJ	Degree=Pos	_	_	_	_
32	remission	remission	NOUN	NN	Number=Sing	_	_	_	_
33	in	in	ADP	IN	_	_	_	_	_
34	patients	patient	NOUN	NNS	Number=Plur	_	_	_	_
35	with	with	ADP	IN	_	_	_	_	_
36	acute	acute	ADJ	JJ	Degree=Pos	_	_	_	_
37	promyelocytic	promyelocytic	ADJ	JJ	Degree=Pos	_	_	_	_
38	leukemia	leukemia	NOUN	NN	Number=Sing	_	_	_	_
39	via	via	ADP	IN	_	_	_	_	_
40	induction	induction	NOUN	NN	Number=Sing	_	_	_	_
41	of	of	ADP	IN	_	_	_	_	_
42	differentiation	differentiation	NOUN	NN	Number=Sing	_	_	_	_
43	and	and	CCONJ	CC	_	_	_	_	_
44	programmed	programm	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
45	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
46	death	death	NOUN	NN	Number=Sing	_	_	_	_
47	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
48	apoptosis	apoptosis	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
49	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
50	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1913
# text = We investigated the effects of As2O3 on a panel of malignant lymphocytes to determine whether growth-inhibitory and apoptotic effects of As2O3 can be observed in these cells at clinically achievable concentrations.
1	We	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
2	investigated	investigate	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
3	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
4	effects	effect	NOUN	NNS	Number=Plur	_	_	_	_
5	of	of	ADP	IN	_	_	_	_	_
6	As2O3	As2O3	NUM	CD	NumType=Card	_	_	_	_
7	on	on	ADP	IN	_	_	_	_	_
8	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
9	panel	panel	NOUN	NN	Number=Sing	_	_	_	_
10	of	of	ADP	IN	_	_	_	_	_
11	malignant	malignant	ADJ	JJ	Degree=Pos	_	_	_	_
12	lymphocytes	lymphocyte	NOUN	NNS	Number=Plur	_	_	_	_
13	to	to	PART	TO	_	_	_	_	_
14	determine	determine	VERB	VB	VerbForm=Inf	_	_	_	_
15	whether	whether	SCONJ	IN	_	_	_	_	_
16	growth	growth	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
17	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
18	inhibitory	inhibitory	NOUN	NN	Number=Sing	_	_	_	_
19	and	and	CCONJ	CC	_	_	_	_	_
20	apoptotic	apoptotic	ADJ	JJ	Degree=Pos	_	_	_	_
21	effects	effect	NOUN	NNS	Number=Plur	_	_	_	_
22	of	of	ADP	IN	_	_	_	_	_
23	As2O3	As2O3	NOUN	NN	Number=Sing	_	_	_	_
24	can	can	AUX	MD	VerbForm=Fin	_	_	_	_
25	be	be	AUX	VB	VerbForm=Inf	_	_	_	_
26	observed	observe	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
27	in	in	ADP	IN	_	_	_	_	_
28	these	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
29	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
30	at	at	ADP	IN	_	_	_	_	_
31	clinically	clinically	ADV	RB	_	_	_	_	_
32	achievable	achievable	ADJ	JJ	Degree=Pos	_	_	_	_
33	concentrations	concentration	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
34	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1914
# text = METHODS: Eight malignant lymphocytic cell lines and primary cultures of lymphocytic leukemia and lymphoma cells were treated with As2O3, with or without dithiothreitol (DTT) or buthionine sulfoximine (BSO) (an inhibitor of glutathione synthesis).
1	METHODS	method	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
2	:	:	PUNCT	:	_	_	_	_	_
3	Eight	eight	PROPN	NNP	Number=Sing	_	_	_	_
4	malignant	malignant	ADJ	JJ	Degree=Pos	_	_	_	_
5	lymphocytic	lymphocytic	ADJ	JJ	Degree=Pos	_	_	_	_
6	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
7	lines	line	NOUN	NNS	Number=Plur	_	_	_	_
8	and	and	CCONJ	CC	_	_	_	_	_
9	primary	primary	ADJ	JJ	Degree=Pos	_	_	_	_
10	cultures	culture	NOUN	NNS	Number=Plur	_	_	_	_
11	of	of	ADP	IN	_	_	_	_	_
12	lymphocytic	lymphocytic	ADJ	JJ	Degree=Pos	_	_	_	_
13	leukemia	leukemia	NOUN	NN	Number=Sing	_	_	_	_
14	and	and	CCONJ	CC	_	_	_	_	_
15	lymphoma	lymphoma	NOUN	NN	Number=Sing	_	_	_	_
16	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
17	were	be	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
18	treated	treat	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
19	with	with	ADP	IN	_	_	_	_	_
20	As2O3	As2O3	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
21	,	,	PUNCT	,	_	_	_	_	_
22	with	with	ADP	IN	_	_	_	_	_
23	or	or	CCONJ	CC	_	_	_	_	_
24	without	without	ADP	IN	_	_	_	_	_
25	dithiothreitol	dithiothreitol	NOUN	NN	Number=Sing	_	_	_	_
26	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
27	DTT	DTT	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
28	)	)	PUNCT	-RRB-	_	_	_	_	_
29	or	or	CCONJ	CC	_	_	_	_	_
30	buthionine	buthionine	NUM	CD	NumType=Card	_	_	_	_
31	sulfoximine	sulfoximine	NOUN	NN	Number=Sing	_	_	_	_
32	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
33	BSO	BSO	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
34	)	)	PUNCT	-RRB-	_	_	_	_	_
35	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
36	an	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
37	inhibitor	inhibitor	NOUN	NN	Number=Sing	_	_	_	_
38	of	of	ADP	IN	_	_	_	_	_
39	glutathione	glutathione	ADJ	JJ	Degree=Pos	_	_	_	_
40	synthesis	synthesis	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
41	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
42	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1915
# text = Apoptosis was assessed by cell morphology, flow cytometry, annexin V protein level, and terminal deoxynucleotidyl transferase labeling of DNA fragments.
1	Apoptosis	Apoptosis	PRON	DT	Number=Sing|PronType=Dem	_	_	_	_
2	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
3	assessed	assess	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
4	by	by	ADP	IN	_	_	_	_	_
5	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
6	morphology	morphology	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
7	,	,	PUNCT	,	_	_	_	_	_
8	flow	flow	NOUN	NN	Number=Sing	_	_	_	_
9	cytometry	cytometry	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
10	,	,	PUNCT	,	_	_	_	_	_
11	annexin	annexin	ADP	IN	_	_	_	_	_
12	V	V	PROPN	NNP	Number=Sing	_	_	_	_
13	protein	protein	NOUN	NN	Number=Sing	_	_	_	_
14	level	level	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
15	,	,	PUNCT	,	_	_	_	_	_
16	and	and	CCONJ	CC	_	_	_	_	_
17	terminal	terminal	ADJ	JJ	Degree=Pos	_	_	_	_
18	deoxynucleotidyl	deoxynucleotidyl	NOUN	NN	Number=Sing	_	_	_	_
19	transferase	transferase	NOUN	NN	Number=Sing	_	_	_	_
20	labeling	labeling	NOUN	NN	Number=Sing	_	_	_	_
21	of	of	ADP	IN	_	_	_	_	_
22	DNA	dna	NOUN	NN	Number=Sing	_	_	_	_
23	fragments	fragment	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
24	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1916
# text = Cellular proliferation was determined by 5-bromo-2'-deoxyuridine incorporation into DNA and flow cytometry and by use of a mitotic arrest assay.
1	Cellular	celular	ADJ	JJ	Degree=Pos	_	_	_	_
2	proliferation	proliferation	NOUN	NN	Number=Sing	_	_	_	_
3	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
4	determined	determine	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
5	by	by	ADP	IN	_	_	_	_	_
6	5	5	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
7	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
8	bromo	bromo	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
9	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
10	2	2	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
11	'-	'-	PUNCT	.	_	_	_	_	SpaceAfter=No
12	deoxyuridine	deoxyuridine	NOUN	NN	Number=Sing	_	_	_	_
13	incorporation	incorporation	NOUN	NN	Number=Sing	_	_	_	_
14	into	into	ADP	IN	_	_	_	_	_
15	DNA	dna	NOUN	NN	Number=Sing	_	_	_	_
16	and	and	CCONJ	CC	_	_	_	_	_
17	flow	flow	VERB	VB	VerbForm=Inf	_	_	_	_
18	cytometry	cytometry	NOUN	NN	Number=Sing	_	_	_	_
19	and	and	CCONJ	CC	_	_	_	_	_
20	by	by	ADP	IN	_	_	_	_	_
21	use	use	NOUN	NN	Number=Sing	_	_	_	_
22	of	of	ADP	IN	_	_	_	_	_
23	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
24	mitotic	mitotic	ADJ	JJ	Degree=Pos	_	_	_	_
25	arrest	arrest	NOUN	NN	Number=Sing	_	_	_	_
26	assay	assay	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
27	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1917
# text = Mitochondrial transmembrane potential (delta psi(m)) was measured by means of rhodamine 123 staining and flow cytometry.
1	Mitochondrial	Mitochondrial	ADJ	JJ	Degree=Pos	_	_	_	_
2	transmembrane	transmembrane	NOUN	NN	Number=Sing	_	_	_	_
3	potential	potential	NOUN	NN	Number=Sing	_	_	_	_
4	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
5	delta	delta	NOUN	NN	Number=Sing	_	_	_	_
6	psi	psi	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
7	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
8	m	m	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
9	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
10	)	)	PUNCT	-RRB-	_	_	_	_	_
11	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
12	measured	measure	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
13	by	by	ADP	IN	_	_	_	_	_
14	means	means	NOUN	NNS	Number=Plur	_	_	_	_
15	of	of	ADP	IN	_	_	_	_	_
16	rhodamine	rhodamine	NOUN	NN	Number=Sing	_	_	_	_
17	123	123	NUM	CD	NumType=Card	_	_	_	_
18	staining	stain	VERB	VBG	VerbForm=Ger	_	_	_	_
19	and	and	CCONJ	CC	_	_	_	_	_
20	flow	flow	VERB	VB	VerbForm=Inf	_	_	_	_
21	cytometry	cytometry	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
22	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1918
# text = Protein expression was assessed by western blot analysis or immunofluorescence.
1	Protein	protein	NOUN	NN	Number=Sing	_	_	_	_
2	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
3	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
4	assessed	assess	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
5	by	by	ADP	IN	_	_	_	_	_
6	western	western	ADJ	JJ	Degree=Pos	_	_	_	_
7	blot	blot	NOUN	NN	Number=Sing	_	_	_	_
8	analysis	analysis	NOUN	NN	Number=Sing	_	_	_	_
9	or	or	CCONJ	CC	_	_	_	_	_
10	immunofluorescence	immunofluorescence	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
11	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1919
# text = RESULTS: Therapeutic concentrations of As2O3 (1-2 microM) had dual effects on malignant lymphocytes:
1	RESULTS	result	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
2	:	:	PUNCT	:	_	_	_	_	_
3	Therapeutic	Therapeutic	ADJ	JJ	Degree=Pos	_	_	_	_
4	concentrations	concentration	NOUN	NNS	Number=Plur	_	_	_	_
5	of	of	ADP	IN	_	_	_	_	_
6	As2O3	As2O3	NOUN	NN	Number=Sing	_	_	_	_
7	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
8	1	1	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
9	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
10	2	2	NUM	CD	NumType=Card	_	_	_	_
11	microM	microm	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
12	)	)	PUNCT	-RRB-	_	_	_	_	_
13	had	have	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
14	dual	dual	ADJ	JJ	Degree=Pos	_	_	_	_
15	effects	effect	NOUN	NNS	Number=Plur	_	_	_	_
16	on	on	ADP	IN	_	_	_	_	_
17	malignant	malignant	ADJ	JJ	Degree=Pos	_	_	_	_
18	lymphocytes	lymphocyte	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
19	:	:	PUNCT	:	_	_	_	_	_

# sent_id = 1920
# text = 1) inhibition of growth through adenosine triphosphate (ATP) depletion and prolongation of cell cycle time and 2) induction of apoptosis.
1	1	1	X	LS	_	_	_	_	SpaceAfter=No
2	)	)	PUNCT	-RRB-	_	_	_	_	_
3	inhibition	inhibition	NOUN	NN	Number=Sing	_	_	_	_
4	of	of	ADP	IN	_	_	_	_	_
5	growth	growth	NOUN	NN	Number=Sing	_	_	_	_
6	through	through	ADP	IN	_	_	_	_	_
7	adenosine	adenosine	NOUN	NN	Number=Sing	_	_	_	_
8	triphosphate	triphosphate	NOUN	NN	Number=Sing	_	_	_	_
9	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
10	ATP	ATP	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
11	)	)	PUNCT	-RRB-	_	_	_	_	_
12	depletion	depletion	NOUN	NN	Number=Sing	_	_	_	_
13	and	and	CCONJ	CC	_	_	_	_	_
14	prolongation	prolongation	NOUN	NN	Number=Sing	_	_	_	_
15	of	of	ADP	IN	_	_	_	_	_
16	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
17	cycle	cycle	NOUN	NN	Number=Sing	_	_	_	_
18	time	time	NOUN	NN	Number=Sing	_	_	_	_
19	and	and	CCONJ	CC	_	_	_	_	_
20	2	2	X	LS	_	_	_	_	SpaceAfter=No
21	)	)	PUNCT	-RRB-	_	_	_	_	_
22	induction	induction	NOUN	NN	Number=Sing	_	_	_	_
23	of	of	ADP	IN	_	_	_	_	_
24	apoptosis.	apoptosis.	NOUN	NN	Number=Sing	_	_	_	_

# sent_id = 1921
# text = As2O3-induced apoptosis was preceded by delta psi(m) collapse.
1	As2O3	As2O3	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
2	-	-	PUNCT	:	_	_	_	_	SpaceAfter=No
3	induced	induce	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
4	apoptosis	apoptosis	NOUN	NN	Number=Sing	_	_	_	_
5	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
6	preceded	preced	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
7	by	by	ADP	IN	_	_	_	_	_
8	delta	delta	NOUN	NN	Number=Sing	_	_	_	_
9	psi	psi	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
10	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
11	m	m	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
12	)	)	PUNCT	-RRB-	_	_	_	_	_
13	collapse	collapse	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
14	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1922
# text = DTT antagonized and BSO enhanced As2O3-induced ATP depletion, delta psi(m) collapse, and apoptosis.
1	DTT	DTT	PROPN	NNP	Number=Sing	_	_	_	_
2	antagonized	antagonize	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
3	and	and	CCONJ	CC	_	_	_	_	_
4	BSO	BSO	PROPN	NNP	Number=Sing	_	_	_	_
5	enhanced	enhance	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
6	As2O3	As2O3	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
7	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
8	induced	induce	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
9	ATP	Atp	NOUN	NN	Number=Sing	_	_	_	_
10	depletion	depletion	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
11	,	,	PUNCT	,	_	_	_	_	_
12	delta	delta	NOUN	NN	Number=Sing	_	_	_	_
13	psi	psi	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
14	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
15	m	m	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
16	)	)	PUNCT	-RRB-	_	_	_	_	_
17	collapse	collapse	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
18	,	,	PUNCT	,	_	_	_	_	_
19	and	and	CCONJ	CC	_	_	_	_	_
20	apoptosis	apoptosis	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	SpaceAfter=No
21	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1923
# text = Caspase-3 activation, usually resulting from delta psi(m) collapse, was not always associated with As2O3-induced apoptosis.
1	Caspase	Caspase	INTJ	UH	_	_	_	_	SpaceAfter=No
2	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
3	3	3	NUM	CD	NumType=Card	_	_	_	_
4	activation	activation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
5	,	,	PUNCT	,	_	_	_	_	_
6	usually	usually	ADV	RB	_	_	_	_	_
7	resulting	result	VERB	VBG	VerbForm=Ger	_	_	_	_
8	from	from	ADP	IN	_	_	_	_	_
9	delta	delta	PROPN	NNP	Number=Sing	_	_	_	_
10	psi	psi	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
11	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
12	m	m	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
13	)	)	PUNCT	-RRB-	_	_	_	_	_
14	collapse	collapse	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
15	,	,	PUNCT	,	_	_	_	_	_
16	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
17	not	not	PART	RB	_	_	_	_	_
18	always	always	ADV	RB	_	_	_	_	_
19	associated	associate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
20	with	with	ADP	IN	_	_	_	_	_
21	As2O3	As2O3	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
22	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
23	induced	induce	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
24	apoptosis	apoptosis	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
25	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1924
# text = As2O3 induced PML (promyelocytic leukemia) protein degradation but did not modulate expression of cell cycle-related proteins, including c-myc, retinoblastoma protein, cyclin-dependent kinase 4, cyclin D1, and p53, or expression of differentiation-related antigens.
1	As2O3	As2O3	X	LS	_	_	_	_	_
2	induced	induce	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
3	PML	pMl	NOUN	NN	Number=Sing	_	_	_	_
4	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
5	promyelocytic	promyelocytic	ADJ	JJ	Degree=Pos	_	_	_	_
6	leukemia	leukemia	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
7	)	)	PUNCT	-RRB-	_	_	_	_	_
8	protein	protein	NOUN	NN	Number=Sing	_	_	_	_
9	degradation	degradation	NOUN	NN	Number=Sing	_	_	_	_
10	but	but	CCONJ	CC	_	_	_	_	_
11	did	do	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
12	not	not	PART	RB	_	_	_	_	_
13	modulate	modulate	VERB	VB	VerbForm=Inf	_	_	_	_
14	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
15	of	of	ADP	IN	_	_	_	_	_
16	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
17	cycle	cycle	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
18	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
19	related	related	ADJ	JJ	Degree=Pos	_	_	_	_
20	proteins	protein	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
21	,	,	PUNCT	,	_	_	_	_	_
22	including	include	VERB	VBG	VerbForm=Ger	_	_	_	_
23	c-	c-	SYM	NFP	_	_	_	_	SpaceAfter=No
24	myc	myc	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
25	,	,	PUNCT	,	_	_	_	_	_
26	retinoblastoma	retinoblastoma	NOUN	NN	Number=Sing	_	_	_	_
27	protein	protein	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
28	,	,	PUNCT	,	_	_	_	_	_
29	cyclin	cyclin	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
30	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
31	dependent	dependent	ADJ	JJ	Degree=Pos	_	_	_	_
32	kinase	kinase	NOUN	NN	Number=Sing	_	_	_	_
33	4	4	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
34	,	,	PUNCT	,	_	_	_	_	_
35	cyclin	cyclin	NOUN	NN	Number=Sing	_	_	_	_
36	D1	d1	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
37	,	,	PUNCT	,	_	_	_	_	_
38	and	and	CCONJ	CC	_	_	_	_	_
39	p53	p53	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
40	,	,	PUNCT	,	_	_	_	_	_
41	or	or	CCONJ	CC	_	_	_	_	_
42	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
43	of	of	ADP	IN	_	_	_	_	_
44	differentiation	differentiation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
45	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
46	related	related	ADJ	JJ	Degree=Pos	_	_	_	_
47	antigens	antigen	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
48	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1925
# text = CONCLUSIONS: Substantial growth inhibition and apoptosis without evidence of differentiation were induced in most malignant lymphocytic cells treated with 1-2 microM As2O3.
1	CONCLUSIONS	conclusion	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
2	:	:	PUNCT	:	_	_	_	_	_
3	Substantial	substantial	ADJ	JJ	Degree=Pos	_	_	_	_
4	growth	growth	NOUN	NN	Number=Sing	_	_	_	_
5	inhibition	inhibition	NOUN	NN	Number=Sing	_	_	_	_
6	and	and	CCONJ	CC	_	_	_	_	_
7	apoptosis	apoptosis	NOUN	NN	Number=Sing	_	_	_	_
8	without	without	ADP	IN	_	_	_	_	_
9	evidence	evidence	NOUN	NN	Number=Sing	_	_	_	_
10	of	of	ADP	IN	_	_	_	_	_
11	differentiation	differentiation	NOUN	NN	Number=Sing	_	_	_	_
12	were	be	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
13	induced	induce	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
14	in	in	ADV	RB	_	_	_	_	_
15	most	most	ADV	RBS	_	_	_	_	_
16	malignant	malignant	ADJ	JJ	Degree=Pos	_	_	_	_
17	lymphocytic	lymphocytic	ADJ	JJ	Degree=Pos	_	_	_	_
18	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
19	treated	treat	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
20	with	with	ADP	IN	_	_	_	_	_
21	1	1	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
22	-	-	SYM	SYM	_	_	_	_	SpaceAfter=No
23	2	2	NUM	CD	NumType=Card	_	_	_	_
24	microM	microm	NOUN	NN	Number=Sing	_	_	_	_
25	As2	As2	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
26	O3	O3	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
27	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1926
# text = As2O3 may prove useful in the treatment of malignant lymphoproliferative disorders.
1	As	as	ADP	IN	_	_	_	_	SpaceAfter=No
2	2O3	2O3	NUM	CD	NumType=Card	_	_	_	_
3	may	may	AUX	MD	VerbForm=Fin	_	_	_	_
4	prove	prove	VERB	VB	VerbForm=Inf	_	_	_	_
5	useful	useful	ADJ	JJ	Degree=Pos	_	_	_	_
6	in	in	ADP	IN	_	_	_	_	_
7	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
8	treatment	treatment	NOUN	NN	Number=Sing	_	_	_	_
9	of	of	ADP	IN	_	_	_	_	_
10	malignant	malignant	ADJ	JJ	Degree=Pos	_	_	_	_
11	lymphoproliferative	lymphoproliferative	ADJ	JJ	Degree=Pos	_	_	_	_
12	disorders	disorder	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
13	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 1927
# text = Document 00300389 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	00300389	00300389	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 1928
# text = The Legionella pneumophila rpoS gene is required for growth within Acanthamoeba castellanii.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	Legionella	Legionella	PROPN	NNP	Number=Sing	_	_	_	_
3	pneumophila	pneumophila	NOUN	NN	Number=Sing	_	_	_	_
4	rpoS	rpos	NOUN	NN	Number=Sing	_	_	_	_
5	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
6	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
7	required	require	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
8	for	for	ADP	IN	_	_	_	_	_
9	growth	growth	NOUN	NN	Number=Sing	_	_	_	_
10	within	within	ADP	IN	_	_	_	_	_
11	Acanthamoeba	Acanthamoeba	PROPN	NNP	Number=Sing	_	_	_	_
12	castellanii	castellanii	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
13	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 1929
# text = To investigate regulatory networks in Legionella pneumophila, the gene encoding the homolog of the Escherichia coli stress and stationary-phase sigma factor RpoS was identified by complementation of an E. coli rpoS mutation.
1	To	to	PART	TO	_	_	_	_	_
2	investigate	investigate	VERB	VB	VerbForm=Inf	_	_	_	_
3	regulatory	regulatory	ADJ	JJ	Degree=Pos	_	_	_	_
4	networks	network	NOUN	NNS	Number=Plur	_	_	_	_
5	in	in	ADP	IN	_	_	_	_	_
6	Legionella	Legionella	PROPN	NNP	Number=Sing	_	_	_	_
7	pneumophila	pneumophila	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
8	,	,	PUNCT	,	_	_	_	_	_
9	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
10	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
11	encoding	encod	VERB	VBG	VerbForm=Ger	_	_	_	_
12	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
13	homolog	homolog	NOUN	NN	Number=Sing	_	_	_	_
14	of	of	ADP	IN	_	_	_	_	_
15	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
16	Escherichia	Escherichia	PROPN	NNP	Number=Sing	_	_	_	_
17	coli	coli	NOUN	NN	Number=Sing	_	_	_	_
18	stress	stress	NOUN	NN	Number=Sing	_	_	_	_
19	and	and	CCONJ	CC	_	_	_	_	_
20	stationary	stationary	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
21	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
22	phase	phase	NOUN	NN	Number=Sing	_	_	_	_
23	sigma	sigma	NOUN	NN	Number=Sing	_	_	_	_
24	factor	factor	NOUN	NN	Number=Sing	_	_	_	_
25	RpoS	Rpos	PROPN	NNP	Number=Sing	_	_	_	_
26	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
27	identified	identify	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
28	by	by	ADP	IN	_	_	_	_	_
29	complementation	complementation	NOUN	NN	Number=Sing	_	_	_	_
30	of	of	ADP	IN	_	_	_	_	_
31	an	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
32	E.	E.	PROPN	NNP	Number=Sing	_	_	_	_
33	coli	coli	NOUN	NN	Number=Sing	_	_	_	_
34	rpoS	rpos	NOUN	NN	Number=Sing	_	_	_	_
35	mutation	mutation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
36	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1930
# text = An open reading frame that is approximately 60% identical to the E.
1	An	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
2	open	open	ADJ	JJ	Degree=Pos	_	_	_	_
3	reading	reading	NOUN	NN	Number=Sing	_	_	_	_
4	frame	frame	NOUN	NN	Number=Sing	_	_	_	_
5	that	that	PRON	WDT	PronType=Rel	_	_	_	_
6	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
7	approximately	approximately	ADV	RB	_	_	_	_	_
8	60	60	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
9	%	%	SYM	NN	Number=Sing	_	_	_	_
10	identical	identical	ADJ	JJ	Degree=Pos	_	_	_	_
11	to	to	ADP	IN	_	_	_	_	_
12	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
13	E.	E.	PROPN	NNP	Number=Sing	_	_	_	_

# sent_id = 1931
# text = coli rpoS gene was identified.
1	coli	coli	NOUN	NN	Number=Sing	_	_	_	_
2	rpoS	rpos	NOUN	NN	Number=Sing	_	_	_	_
3	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
4	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
5	identified	identify	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	SpaceAfter=No
6	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1932
# text = Western blot analysis showed that the level of L.
1	Western	western	ADJ	JJ	Degree=Pos	_	_	_	_
2	blot	blot	NOUN	NN	Number=Sing	_	_	_	_
3	analysis	analysis	NOUN	NN	Number=Sing	_	_	_	_
4	showed	show	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
5	that	that	SCONJ	IN	_	_	_	_	_
6	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
7	level	level	NOUN	NN	Number=Sing	_	_	_	_
8	of	of	ADP	IN	_	_	_	_	_
9	L.	L.	PROPN	NNP	Number=Sing	_	_	_	_

# sent_id = 1933
# text = pneumophila
1	pneumophila	pneumophila	NOUN	NN	Number=Sing	_	_	_	_

# sent_id = 1934
# text = RpoS increased in stationary phase.
1	RpoS	Rpo	NOUN	NNS	Number=Plur	_	_	_	_
2	increased	increase	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
3	in	in	ADP	IN	_	_	_	_	_
4	stationary	stationary	ADJ	JJ	Degree=Pos	_	_	_	_
5	phase	phase	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
6	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1935
# text = An insertion mutation was constructed in the rpoS gene on the chromosome of L. pneumophila, and the ability of this mutant strain to survive various stress conditions was assayed and compared with results for the wild-type strain.
1	An	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
2	insertion	insertion	NOUN	NN	Number=Sing	_	_	_	_
3	mutation	mutation	NOUN	NN	Number=Sing	_	_	_	_
4	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
5	constructed	construct	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
6	in	in	ADP	IN	_	_	_	_	_
7	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
8	rpoS	rpoS	NOUN	NN	Number=Sing	_	_	_	_
9	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
10	on	on	ADP	IN	_	_	_	_	_
11	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
12	chromosome	chromosome	NOUN	NN	Number=Sing	_	_	_	_
13	of	of	ADP	IN	_	_	_	_	_
14	L.	L.	PROPN	NNP	Number=Sing	_	_	_	_
15	pneumophila	pneumophila	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
16	,	,	PUNCT	,	_	_	_	_	_
17	and	and	CCONJ	CC	_	_	_	_	_
18	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
19	ability	ability	NOUN	NN	Number=Sing	_	_	_	_
20	of	of	ADP	IN	_	_	_	_	_
21	this	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
22	mutant	mutant	ADJ	JJ	Degree=Pos	_	_	_	_
23	strain	strain	NOUN	NN	Number=Sing	_	_	_	_
24	to	to	PART	TO	_	_	_	_	_
25	survive	survive	VERB	VB	VerbForm=Inf	_	_	_	_
26	various	various	ADJ	JJ	Degree=Pos	_	_	_	_
27	stress	stress	NOUN	NN	Number=Sing	_	_	_	_
28	conditions	condition	NOUN	NNS	Number=Plur	_	_	_	_
29	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
30	assayed	assay	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
31	and	and	CCONJ	CC	_	_	_	_	_
32	compared	compare	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
33	with	with	ADP	IN	_	_	_	_	_
34	results	result	NOUN	NNS	Number=Plur	_	_	_	_
35	for	for	ADP	IN	_	_	_	_	_
36	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
37	wild	wild	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
38	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
39	type	type	NOUN	NN	Number=Sing	_	_	_	_
40	strain	strain	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
41	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1936
# text = Both the mutant and wild-type strains were more resistant to stress when in stationary phase than when in the logarithmic phase of growth.
1	Both	both	CCONJ	CC	_	_	_	_	_
2	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
3	mutant	mutant	ADJ	JJ	Degree=Pos	_	_	_	_
4	and	and	CCONJ	CC	_	_	_	_	_
5	wild	wild	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
6	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
7	type	type	NOUN	NN	Number=Sing	_	_	_	_
8	strains	strains	NOUN	NNS	Number=Plur	_	_	_	_
9	were	be	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
10	more	more	ADV	RBR	_	_	_	_	_
11	resistant	resistant	ADJ	JJ	Degree=Pos	_	_	_	_
12	to	to	PART	TO	_	_	_	_	_
13	stress	stress	VERB	VB	VerbForm=Inf	_	_	_	_
14	when	when	ADV	WRB	PronType=Int	_	_	_	_
15	in	in	ADP	IN	_	_	_	_	_
16	stationary	stationary	ADJ	JJ	Degree=Pos	_	_	_	_
17	phase	phase	NOUN	NN	Number=Sing	_	_	_	_
18	than	than	SCONJ	IN	_	_	_	_	_
19	when	when	ADV	WRB	PronType=Int	_	_	_	_
20	in	in	ADP	IN	_	_	_	_	_
21	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
22	logarithmic	logarithmic	ADJ	JJ	Degree=Pos	_	_	_	_
23	phase	phase	NOUN	NN	Number=Sing	_	_	_	_
24	of	of	ADP	IN	_	_	_	_	_
25	growth	growth	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
26	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1937
# text = This finding indicates that L. pneumophila
1	This	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
2	finding	finding	NOUN	NN	Number=Sing	_	_	_	_
3	indicates	indicate	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
4	that	that	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
5	L.	L.	PROPN	NNP	Number=Sing	_	_	_	_
6	pneumophila	pneumophila	NOUN	NN	Number=Sing	_	_	_	_

# sent_id = 1938
# text = RpoS is not required for a stationary-phase-dependent resistance to stress.
1	RpoS	RpoS	PROPN	NNP	Number=Sing	_	_	_	_
2	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
3	not	not	PART	RB	_	_	_	_	_
4	required	require	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
5	for	for	ADP	IN	_	_	_	_	_
6	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
7	stationary	stationary	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
8	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
9	phase	phase	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
10	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
11	dependent	dependent	ADJ	JJ	Degree=Pos	_	_	_	_
12	resistance	resistance	NOUN	NN	Number=Sing	_	_	_	_
13	to	to	ADP	IN	_	_	_	_	_
14	stress	stress	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
15	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1939
# text = Although the mutant strain was able to kill HL-60- and THP-1-derived macrophages, it could not replicate within a protozoan host, Acanthamoeba castellanii.
1	Although	although	SCONJ	IN	_	_	_	_	_
2	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
3	mutant	mutant	ADJ	JJ	Degree=Pos	_	_	_	_
4	strain	strain	NOUN	NN	Number=Sing	_	_	_	_
5	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
6	able	able	ADJ	JJ	Degree=Pos	_	_	_	_
7	to	to	PART	TO	_	_	_	_	_
8	kill	kill	VERB	VB	VerbForm=Inf	_	_	_	_
9	HL	HL	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
10	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
11	60	60	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
12	-	-	PUNCT	HYPH	_	_	_	_	_
13	and	and	CCONJ	CC	_	_	_	_	_
14	THP	Thp	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
15	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
16	1	1	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
17	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
18	derived	derive	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
19	macrophages	macrophage	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
20	,	,	PUNCT	,	_	_	_	_	_
21	it	it	PRON	PRP	Case=Nom|Gender=Neut|Number=Sing|Person=3|PronType=Prs	_	_	_	_
22	could	could	AUX	MD	VerbForm=Fin	_	_	_	_
23	not	not	PART	RB	_	_	_	_	_
24	replicate	replicate	VERB	VB	VerbForm=Inf	_	_	_	_
25	within	within	ADP	IN	_	_	_	_	_
26	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
27	protozoan	protozoan	NOUN	NN	Number=Sing	_	_	_	_
28	host	host	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
29	,	,	PUNCT	,	_	_	_	_	_
30	Acanthamoeba	Acanthamoeba	PROPN	NNP	Number=Sing	_	_	_	_
31	castellanii	castellanii	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
32	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1940
# text = These data suggest that L.
1	These	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
2	data	data	NOUN	NN	Number=Sing	_	_	_	_
3	suggest	suggest	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
4	that	that	SCONJ	IN	_	_	_	_	_
5	L.	L.	PROPN	NNP	Number=Sing	_	_	_	_

# sent_id = 1941
# text = pneumophila possesses a growth phase-dependent resistance to stress that is independent of RpoS control and that RpoS likely regulates genes that enable it to survive in the environment within protozoa.
1	pneumophila	pneumophila	NOUN	NN	Number=Sing	_	_	_	_
2	possesses	possess	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
3	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
4	growth	growth	NOUN	NN	Number=Sing	_	_	_	_
5	phase	phase	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
6	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
7	dependent	dependent	ADJ	JJ	Degree=Pos	_	_	_	_
8	resistance	resistance	NOUN	NN	Number=Sing	_	_	_	_
9	to	to	ADP	IN	_	_	_	_	_
10	stress	stress	NOUN	NNS	Number=Plur	_	_	_	_
11	that	that	PRON	WDT	PronType=Rel	_	_	_	_
12	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
13	independent	independent	ADJ	JJ	Degree=Pos	_	_	_	_
14	of	of	ADP	IN	_	_	_	_	_
15	RpoS	Rpos	ADJ	JJ	Degree=Pos	_	_	_	_
16	control	control	NOUN	NN	Number=Sing	_	_	_	_
17	and	and	CCONJ	CC	_	_	_	_	_
18	that	that	SCONJ	IN	_	_	_	_	_
19	RpoS	RpoS	PROPN	NNP	Number=Sing	_	_	_	_
20	likely	likely	ADV	RB	_	_	_	_	_
21	regulates	regulate	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
22	genes	gene	NOUN	NNS	Number=Plur	_	_	_	_
23	that	that	PRON	WDT	PronType=Rel	_	_	_	_
24	enable	enable	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
25	it	it	PRON	PRP	Case=Acc|Gender=Neut|Number=Sing|Person=3|PronType=Prs	_	_	_	_
26	to	to	PART	TO	_	_	_	_	_
27	survive	survive	VERB	VB	VerbForm=Inf	_	_	_	_
28	in	in	ADP	IN	_	_	_	_	_
29	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
30	environment	environment	NOUN	NN	Number=Sing	_	_	_	_
31	within	within	ADP	IN	_	_	_	_	_
32	protozoa	protozoa	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
33	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1942
# text = Our data indicate that the role of rpoS in L. pneumophila is very different from what has previously been reported for E. coli rpoS.
1	Our	we	PRON	PRP$	Number=Plur|Person=1|Poss=Yes|PronType=Prs	_	_	_	_
2	data	data	NOUN	NN	Number=Sing	_	_	_	_
3	indicate	indicate	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
4	that	that	SCONJ	IN	_	_	_	_	_
5	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
6	role	role	NOUN	NN	Number=Sing	_	_	_	_
7	of	of	ADP	IN	_	_	_	_	_
8	rpoS	rpo	PROPN	NNP	Number=Sing	_	_	_	_
9	in	in	ADP	IN	_	_	_	_	_
10	L.	L.	PROPN	NNP	Number=Sing	_	_	_	_
11	pneumophila	pneumophila	PROPN	NNP	Number=Sing	_	_	_	_
12	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
13	very	very	ADV	RB	_	_	_	_	_
14	different	different	ADJ	JJ	Degree=Pos	_	_	_	_
15	from	from	SCONJ	IN	_	_	_	_	_
16	what	what	PRON	WP	PronType=Int	_	_	_	_
17	has	have	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
18	previously	previously	ADV	RB	_	_	_	_	_
19	been	be	AUX	VBN	Tense=Past|VerbForm=Part	_	_	_	_
20	reported	report	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
21	for	for	ADP	IN	_	_	_	_	_
22	E.	E.	PROPN	NNP	Number=Sing	_	_	_	_
23	coli	coli	PROPN	NNPS	Number=Plur	_	_	_	_
24	rpoS.	rpoS.	PROPN	NNP	Number=Sing	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 1943
# text = Document 00300390 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	00300390	00300390	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 1944
# text = Modulation of CD28 expression: distinct regulatory pathways during activation and replicative senescence.
1	Modulation	Modulation	NOUN	NN	Number=Sing	_	_	_	_
2	of	of	ADP	IN	_	_	_	_	_
3	CD28	CD28	NUM	CD	NumType=Card	_	_	_	_
4	expression	expression	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
5	:	:	PUNCT	:	_	_	_	_	_
6	distinct	distinct	ADJ	JJ	Degree=Pos	_	_	_	_
7	regulatory	regulatory	ADJ	JJ	Degree=Pos	_	_	_	_
8	pathways	pathway	NOUN	NNS	Number=Plur	_	_	_	_
9	during	during	ADP	IN	_	_	_	_	_
10	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
11	and	and	CCONJ	CC	_	_	_	_	_
12	replicative	replicative	ADJ	JJ	Degree=Pos	_	_	_	_
13	senescence	senescence	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
14	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 1945
# text = The costimulatory molecule CD28 has a restricted tissue distribution and is expressed on T cells and some plasmacytoma cells.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	costimulatory	costimulatory	ADJ	JJ	Degree=Pos	_	_	_	_
3	molecule	molecule	NOUN	NN	Number=Sing	_	_	_	_
4	CD28	CD28	NOUN	NN	Number=Sing	_	_	_	_
5	has	have	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
6	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
7	restricted	restricted	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
8	tissue	tissue	NOUN	NN	Number=Sing	_	_	_	_
9	distribution	distribution	NOUN	NN	Number=Sing	_	_	_	_
10	and	and	CCONJ	CC	_	_	_	_	_
11	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
12	expressed	expressed	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
13	on	on	ADP	IN	_	_	_	_	_
14	T	t	PROPN	NNP	Number=Sing	_	_	_	_
15	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
16	and	and	CCONJ	CC	_	_	_	_	_
17	some	some	DET	DT	_	_	_	_	_
18	plasmacytoma	plasmacytoma	NOUN	NN	Number=Sing	_	_	_	_
19	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
20	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1946
# text = Although CD28 is constitutively expressed, its expression is transiently down-regulated following T cell activation and declines progressively with in vitro senescence.
1	Although	although	SCONJ	IN	_	_	_	_	_
2	CD28	CD28	PROPN	NNP	Number=Sing	_	_	_	_
3	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
4	constitutively	constitutively	ADV	RB	_	_	_	_	_
5	expressed	express	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	SpaceAfter=No
6	,	,	PUNCT	,	_	_	_	_	_
7	its	its	PRON	PRP$	Gender=Neut|Number=Sing|Person=3|Poss=Yes|PronType=Prs	_	_	_	_
8	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
9	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
10	transiently	transiently	ADV	RB	_	_	_	_	_
11	down	down	ADV	RB	_	_	_	_	SpaceAfter=No
12	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
13	regulated	regulate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
14	following	follow	VERB	VBG	VerbForm=Ger	_	_	_	_
15	T	t	NUM	CD	NumType=Card	_	_	_	_
16	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
17	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
18	and	and	CCONJ	CC	_	_	_	_	_
19	declines	decline	NOUN	NNS	Number=Plur	_	_	_	_
20	progressively	progressively	ADV	RB	_	_	_	_	_
21	with	with	ADP	IN	_	_	_	_	_
22	in	in	ADP	IN	_	_	_	_	_
23	vitro	vitro	NOUN	NN	Number=Sing	_	_	_	_
24	senescence	senescence	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
25	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1947
# text = In vivo, CD8+ T cells and, less frequently, CD4+ T cells may completely lose CD28 surface expression during chronic infections and with aging.
1	In	in	ADP	IN	_	_	_	_	_
2	vivo	vivo	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
3	,	,	PUNCT	,	_	_	_	_	_
4	CD8	CD8	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
5	+	+	SYM	SYM	_	_	_	_	_
6	T	t	NUM	CD	NumType=Card	_	_	_	_
7	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
8	and	and	CCONJ	CC	_	_	_	_	SpaceAfter=No
9	,	,	PUNCT	,	_	_	_	_	_
10	less	less	ADV	RBR	Degree=Cmp	_	_	_	_
11	frequently	frequently	ADV	RB	_	_	_	_	SpaceAfter=No
12	,	,	PUNCT	,	_	_	_	_	_
13	CD4	CD4	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
14	+	+	SYM	SYM	_	_	_	_	_
15	T	t	NUM	CD	NumType=Card	_	_	_	_
16	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
17	may	may	AUX	MD	VerbForm=Fin	_	_	_	_
18	completely	completely	ADV	RB	_	_	_	_	_
19	lose	lose	VERB	VB	VerbForm=Inf	_	_	_	_
20	CD28	CD28	NUM	CD	NumType=Card	_	_	_	_
21	surface	surface	NOUN	NN	Number=Sing	_	_	_	_
22	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
23	during	during	ADP	IN	_	_	_	_	_
24	chronic	chronic	ADJ	JJ	Degree=Pos	_	_	_	_
25	infections	infection	NOUN	NNS	Number=Plur	_	_	_	_
26	and	and	CCONJ	CC	_	_	_	_	_
27	with	with	SCONJ	IN	_	_	_	_	_
28	aging	ag	VERB	VBG	VerbForm=Ger	_	_	_	SpaceAfter=No
29	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1948
# text = This correlates with changes of nuclear protein-binding activities to two motifs, site alpha and beta, within the CD28 minimal promoter.
1	This	this	PRON	DT	Number=Sing|PronType=Dem	_	_	_	_
2	correlates	correlate	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
3	with	with	ADP	IN	_	_	_	_	_
4	changes	change	NOUN	NNS	Number=Plur	_	_	_	_
5	of	of	ADP	IN	_	_	_	_	_
6	nuclear	nuclear	ADJ	JJ	Degree=Pos	_	_	_	_
7	protein-	protein-	PUNCT	,	_	_	_	_	SpaceAfter=No
8	binding	bind	VERB	VBG	VerbForm=Ger	_	_	_	_
9	activities	activity	NOUN	NNS	Number=Plur	_	_	_	_
10	to	to	ADP	IN	_	_	_	_	_
11	two	two	NUM	CD	NumType=Card	_	_	_	_
12	motifs	motif	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
13	,	,	PUNCT	,	_	_	_	_	_
14	site	site	NOUN	NN	Number=Sing	_	_	_	_
15	alpha	alpha	NOUN	NN	Number=Sing	_	_	_	_
16	and	and	CCONJ	CC	_	_	_	_	_
17	beta	beta	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
18	,	,	PUNCT	,	_	_	_	_	_
19	within	within	ADP	IN	_	_	_	_	_
20	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
21	CD28	CD28	PROPN	NNP	Number=Sing	_	_	_	_
22	minimal	minimal	ADJ	JJ	Degree=Pos	_	_	_	_
23	promoter	promoter	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
24	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1949
# text = Both alpha- and beta-bound complexes are found only in lymphoid tissues, in CD28+ T cells, and in some transformed B cells.
1	Both	both	DET	DT	_	_	_	_	_
2	alpha	alpha	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
3	-	-	PUNCT	,	_	_	_	_	_
4	and	and	CCONJ	CC	_	_	_	_	_
5	beta	beta	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
6	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
7	bound	bound	ADJ	JJ	Degree=Pos	_	_	_	_
8	complexes	complex	NOUN	NNS	Number=Plur	_	_	_	_
9	are	be	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
10	found	find	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
11	only	only	ADV	RB	_	_	_	_	_
12	in	in	ADP	IN	_	_	_	_	_
13	lymphoid	lymphoid	ADJ	JJ	Degree=Pos	_	_	_	_
14	tissues	tissue	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
15	,	,	PUNCT	,	_	_	_	_	_
16	in	in	ADP	IN	_	_	_	_	_
17	CD28	CD28	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
18	+	+	SYM	SYM	_	_	_	_	_
19	T	t	NUM	CD	NumType=Card	_	_	_	_
20	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
21	,	,	PUNCT	,	_	_	_	_	_
22	and	and	CCONJ	CC	_	_	_	_	_
23	in	in	ADP	IN	_	_	_	_	_
24	some	some	DET	DT	_	_	_	_	_
25	transformed	transform	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
26	B	b	ADJ	JJ	Degree=Pos	_	_	_	_
27	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
28	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1950
# text = These complexes are coordinately expressed except during replicative senescence, which is characterized by the down-modulation of site beta- but not site alpha-binding activities.
1	These	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
2	complexes	complexe	NOUN	NNS	Number=Plur	_	_	_	_
3	are	be	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
4	coordinately	coordinately	ADV	RB	_	_	_	_	_
5	expressed	express	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
6	except	except	ADP	IN	_	_	_	_	_
7	during	during	ADP	IN	_	_	_	_	_
8	replicative	replicative	ADJ	JJ	Degree=Pos	_	_	_	_
9	senescence	senescence	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
10	,	,	PUNCT	,	_	_	_	_	_
11	which	which	PRON	WDT	PronType=Rel	_	_	_	_
12	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
13	characterized	characterize	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
14	by	by	ADP	IN	_	_	_	_	_
15	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
16	down	down	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
17	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
18	modulation	modulation	NOUN	NN	Number=Sing	_	_	_	_
19	of	of	ADP	IN	_	_	_	_	_
20	site	site	NOUN	NN	Number=Sing	_	_	_	_
21	beta	beta	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
22	-	-	PUNCT	,	_	_	_	_	_
23	but	but	CCONJ	CC	_	_	_	_	_
24	not	not	PART	RB	_	_	_	_	_
25	site	site	NOUN	NN	Number=Sing	_	_	_	_
26	alpha	alpha	ADV	RB	_	_	_	_	SpaceAfter=No
27	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
28	binding	binding	VERB	VBG	VerbForm=Ger	_	_	_	_
29	activities	activity	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
30	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1951
# text = In contrast, T cell activation induces a parallel decline in both site alpha- and beta-binding activities.
1	In	in	ADP	IN	_	_	_	_	_
2	contrast	contrast	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
3	,	,	PUNCT	,	_	_	_	_	_
4	T	t	NUM	CD	NumType=Card	_	_	_	_
5	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
6	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
7	induces	induce	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
8	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
9	parallel	parallel	ADJ	JJ	Degree=Pos	_	_	_	_
10	decline	decline	NOUN	NN	Number=Sing	_	_	_	_
11	in	in	ADP	IN	_	_	_	_	_
12	both	both	DET	DT	_	_	_	_	_
13	site	site	NOUN	NN	Number=Sing	_	_	_	_
14	alpha	alpha	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
15	-	-	PUNCT	,	_	_	_	_	_
16	and	and	CCONJ	CC	_	_	_	_	_
17	beta	beta	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
18	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
19	binding	binding	VERB	VBG	VerbForm=Ger	_	_	_	_
20	activities	activity	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
21	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1952
# text = CD4+ and CD8+
1	CD4	CD4	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
2	+	+	SYM	SYM	_	_	_	_	_
3	and	and	CCONJ	CC	_	_	_	_	_
4	CD8	CD8	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
5	+	+	SYM	NFP	_	_	_	_	_

# sent_id = 1953
# text = T cells differ in their beta-binding profiles, which may explain the more pronounced down-regulation of CD28 in senescent CD8+ T cells.
1	T	t	PROPN	NNP	Number=Sing	_	_	_	_
2	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
3	differ	differ	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
4	in	in	ADP	IN	_	_	_	_	_
5	their	they	PRON	PRP$	Number=Plur|Person=3|Poss=Yes|PronType=Prs	_	_	_	_
6	beta	beta	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
7	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
8	binding	binding	VERB	VBG	VerbForm=Ger	_	_	_	_
9	profiles	profile	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
10	,	,	PUNCT	,	_	_	_	_	_
11	which	which	PRON	WDT	PronType=Rel	_	_	_	_
12	may	may	AUX	MD	VerbForm=Fin	_	_	_	_
13	explain	explain	VERB	VB	VerbForm=Inf	_	_	_	_
14	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
15	more	more	ADV	RBR	_	_	_	_	_
16	pronounced	pronounced	ADJ	JJ	Degree=Pos	_	_	_	_
17	down	down	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
18	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
19	regulation	regulation	NOUN	NN	Number=Sing	_	_	_	_
20	of	of	ADP	IN	_	_	_	_	_
21	CD28	Cd28	NOUN	NN	Number=Sing	_	_	_	_
22	in	in	ADP	IN	_	_	_	_	_
23	senescent	senescent	ADJ	JJ	Degree=Pos	_	_	_	_
24	CD8	CD8	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
25	+	+	SYM	SYM	_	_	_	_	_
26	T	t	NUM	CD	NumType=Card	_	_	_	_
27	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
28	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1954
# text = In vivo expanded CD4+CD28null and CD8+CD28null T cells uniformly lack alpha- and beta- bound complexes, resembling the pattern seen in chronically activated cells and not of senescent cells.
1	In	in	ADP	IN	_	_	_	_	_
2	vivo	vivo	ADP	IN	_	_	_	_	_
3	expanded	expand	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
4	CD4+CD28null	CD4+CD28null	PROPN	NNP	Number=Sing	_	_	_	_
5	and	and	CCONJ	CC	_	_	_	_	_
6	CD8+CD28null	CD8+CD28null	PROPN	NNP	Number=Sing	_	_	_	_
7	T	t	PROPN	NNP	Number=Sing	_	_	_	_
8	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
9	uniformly	uniformly	ADJ	JJ	Degree=Pos	_	_	_	_
10	lack	lack	NOUN	NN	Number=Sing	_	_	_	_
11	alpha	alpha	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
12	-	-	PUNCT	,	_	_	_	_	_
13	and	and	CCONJ	CC	_	_	_	_	_
14	beta	beta	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
15	-	-	PUNCT	HYPH	_	_	_	_	_
16	bound	bound	ADJ	JJ	Degree=Pos	_	_	_	_
17	complexes	complex	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
18	,	,	PUNCT	,	_	_	_	_	_
19	resembling	resembl	VERB	VBG	VerbForm=Ger	_	_	_	_
20	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
21	pattern	pattern	NOUN	NN	Number=Sing	_	_	_	_
22	seen	see	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
23	in	in	ADP	IN	_	_	_	_	_
24	chronically	chronically	ADV	RB	_	_	_	_	_
25	activated	activated	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
26	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
27	and	and	CCONJ	CC	_	_	_	_	_
28	not	not	PART	RB	_	_	_	_	_
29	of	of	ADP	IN	_	_	_	_	_
30	senescent	senescent	ADJ	JJ	Degree=Pos	_	_	_	_
31	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
32	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 1955
# text = Document 00300393 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	00300393	00300393	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 1956
# text = The DNA-binding properties of two heat shock factors, HSF1 and HSF3, are induced in the avian erythroblast cell line HD6.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	DNA	dna	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
3	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
4	binding	binding	VERB	VBG	VerbForm=Ger	_	_	_	_
5	properties	property	NOUN	NNS	Number=Plur	_	_	_	_
6	of	of	ADP	IN	_	_	_	_	_
7	two	two	NUM	CD	NumType=Card	_	_	_	_
8	heat	heat	NOUN	NN	Number=Sing	_	_	_	_
9	shock	shock	NOUN	NN	Number=Sing	_	_	_	_
10	factors	factor	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
11	,	,	PUNCT	,	_	_	_	_	_
12	HSF1	HSF1	NUM	CD	NumType=Card	_	_	_	_
13	and	and	CCONJ	CC	_	_	_	_	_
14	HSF3	HSF3	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
15	,	,	PUNCT	,	_	_	_	_	_
16	are	be	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
17	induced	induce	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
18	in	in	ADP	IN	_	_	_	_	_
19	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
20	avian	avian	ADJ	JJ	Degree=Pos	_	_	_	_
21	erythroblast	erythroblast	ADJ	JJ	Degree=Pos	_	_	_	_
22	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
23	line	line	NOUN	NN	Number=Sing	_	_	_	_
24	HD6	Hd6	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
25	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 1957
# text = Avian cells express three heat shock transcription factor (HSF) genes corresponding to a novel factor, HSF3, and homologs of mouse and human HSF1 and HSF2.
1	Avian	avian	ADJ	JJ	Degree=Pos	_	_	_	_
2	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
3	express	express	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
4	three	three	NUM	CD	NumType=Card	_	_	_	_
5	heat	heat	NOUN	NN	Number=Sing	_	_	_	_
6	shock	shock	NOUN	NN	Number=Sing	_	_	_	_
7	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
8	factor	factor	NOUN	NN	Number=Sing	_	_	_	_
9	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
10	HSF	HSF	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
11	)	)	PUNCT	-RRB-	_	_	_	_	_
12	genes	gene	NOUN	NNS	Number=Plur	_	_	_	_
13	corresponding	correspond	VERB	VBG	VerbForm=Ger	_	_	_	_
14	to	to	ADP	IN	_	_	_	_	_
15	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
16	novel	novel	NOUN	NN	Number=Sing	_	_	_	_
17	factor	factor	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
18	,	,	PUNCT	,	_	_	_	_	_
19	HSF3	HSF3	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
20	,	,	PUNCT	,	_	_	_	_	_
21	and	and	CCONJ	CC	_	_	_	_	_
22	homologs	homolog	NOUN	NNS	Number=Plur	_	_	_	_
23	of	of	ADP	IN	_	_	_	_	_
24	mouse	mouse	NOUN	NN	Number=Sing	_	_	_	_
25	and	and	CCONJ	CC	_	_	_	_	_
26	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
27	HSF1	Hsf1	NOUN	NN	Number=Sing	_	_	_	_
28	and	and	CCONJ	CC	_	_	_	_	_
29	HSF2	Hsf2	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
30	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1958
# text = Analysis of the biochemical and cell biological properties of these HSFs reveals that HSF3 has properties in common with both HSF1 and HSF2 and yet has features which are distinct from both.
1	Analysis	analysis	NOUN	NN	Number=Sing	_	_	_	_
2	of	of	ADP	IN	_	_	_	_	_
3	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
4	biochemical	biochemical	ADJ	JJ	Degree=Pos	_	_	_	_
5	and	and	CCONJ	CC	_	_	_	_	_
6	cell	cell	VERB	VB	VerbForm=Inf	_	_	_	_
7	biological	biological	ADJ	JJ	Degree=Pos	_	_	_	_
8	properties	property	NOUN	NNS	Number=Plur	_	_	_	_
9	of	of	ADP	IN	_	_	_	_	_
10	these	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
11	HSFs	HSF	ADJ	JJ	Degree=Pos	_	_	_	_
12	reveals	reveal	NOUN	NNS	Number=Plur	_	_	_	_
13	that	that	PRON	WDT	PronType=Rel	_	_	_	_
14	HSF3	HSF3	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
15	has	have	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
16	properties	property	NOUN	NNS	Number=Plur	_	_	_	_
17	in	in	ADP	IN	_	_	_	_	_
18	common	common	ADJ	JJ	Degree=Pos	_	_	_	_
19	with	with	ADP	IN	_	_	_	_	_
20	both	both	CCONJ	CC	_	_	_	_	_
21	HSF1	HSF1	NOUN	NN	Number=Sing	_	_	_	_
22	and	and	CCONJ	CC	_	_	_	_	_
23	HSF2	HSF2	NOUN	NN	Number=Sing	_	_	_	_
24	and	and	CCONJ	CC	_	_	_	_	_
25	yet	yet	CCONJ	CC	_	_	_	_	_
26	has	have	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
27	features	feature	NOUN	NNS	Number=Plur	_	_	_	_
28	which	which	PRON	WDT	PronType=Rel	_	_	_	_
29	are	be	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
30	distinct	distinct	ADJ	JJ	Degree=Pos	_	_	_	_
31	from	from	ADP	IN	_	_	_	_	_
32	both	both	DET	DT	_	_	_	_	SpaceAfter=No
33	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1959
# text = HSF3 is constitutively expressed in the erythroblast cell line HD6, the lymphoblast cell line MSB, and embryo fibroblasts, and yet its DNA-binding activity is induced only upon exposure of HD6 cells to heat shock.
1	HSF3	HSF3	NOUN	NN	Number=Sing	_	_	_	_
2	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
3	constitutively	constitutively	ADV	RB	_	_	_	_	_
4	expressed	express	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
5	in	in	ADP	IN	_	_	_	_	_
6	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
7	erythroblast	erythroblast	ADJ	JJ	Degree=Pos	_	_	_	_
8	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
9	line	line	NOUN	NN	Number=Sing	_	_	_	_
10	HD6	HD6	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
11	,	,	PUNCT	,	_	_	_	_	_
12	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
13	lymphoblast	lymphoblast	ADJ	JJ	Degree=Pos	_	_	_	_
14	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
15	line	line	NOUN	NN	Number=Sing	_	_	_	_
16	MSB	Msb	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
17	,	,	PUNCT	,	_	_	_	_	_
18	and	and	CCONJ	CC	_	_	_	_	_
19	embryo	embryo	NOUN	NN	Number=Sing	_	_	_	_
20	fibroblasts	fibroblast	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
21	,	,	PUNCT	,	_	_	_	_	_
22	and	and	CCONJ	CC	_	_	_	_	_
23	yet	yet	ADV	RB	_	_	_	_	_
24	its	its	PRON	PRP$	Gender=Neut|Number=Sing|Person=3|Poss=Yes|PronType=Prs	_	_	_	_
25	DNA	dna	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
26	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
27	binding	binding	VERB	VBG	VerbForm=Ger	_	_	_	_
28	activity	activity	NOUN	NN	Number=Sing	_	_	_	_
29	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
30	induced	induce	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
31	only	only	ADV	RB	_	_	_	_	_
32	upon	upon	ADP	IN	_	_	_	_	_
33	exposure	exposure	NOUN	NN	Number=Sing	_	_	_	_
34	of	of	ADP	IN	_	_	_	_	_
35	HD6	HD6	NUM	CD	NumType=Card	_	_	_	_
36	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
37	to	to	ADP	IN	_	_	_	_	_
38	heat	heat	NOUN	NN	Number=Sing	_	_	_	_
39	shock	shock	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
40	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1960
# text = Acquisition of HSF3 DNA-binding activity in HD6 cells is accompanied by oligomerization from a non-DNA-binding dimer to a DNA-binding trimer, whereas the effect of heat shock on HSF1 is oligomerization of an inert monomer to a DNA-binding trimer.
1	Acquisition	Acquisition	NOUN	NN	Number=Sing	_	_	_	_
2	of	of	ADP	IN	_	_	_	_	_
3	HSF3	HSF3	NUM	CD	NumType=Card	_	_	_	_
4	DNA	dna	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
5	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
6	binding	bind	VERB	VBG	VerbForm=Ger	_	_	_	_
7	activity	activity	NOUN	NN	Number=Sing	_	_	_	_
8	in	in	ADP	IN	_	_	_	_	_
9	HD6	HD6	NUM	CD	NumType=Card	_	_	_	_
10	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
11	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
12	accompanied	accompany	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
13	by	by	ADP	IN	_	_	_	_	_
14	oligomerization	oligomerization	NOUN	NN	Number=Sing	_	_	_	_
15	from	from	ADP	IN	_	_	_	_	_
16	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
17	non-DNA	non-DNa	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
18	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
19	binding	bind	VERB	VBG	VerbForm=Ger	_	_	_	_
20	dimer	dimer	NOUN	NN	Number=Sing	_	_	_	_
21	to	to	ADP	IN	_	_	_	_	_
22	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
23	DNA	dna	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
24	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
25	binding	binding	VERB	VBG	VerbForm=Ger	_	_	_	_
26	trimer	trimer	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
27	,	,	PUNCT	,	_	_	_	_	_
28	whereas	whereas	SCONJ	IN	_	_	_	_	_
29	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
30	effect	effect	NOUN	NN	Number=Sing	_	_	_	_
31	of	of	ADP	IN	_	_	_	_	_
32	heat	heat	NOUN	NN	Number=Sing	_	_	_	_
33	shock	shock	NOUN	NN	Number=Sing	_	_	_	_
34	on	on	ADP	IN	_	_	_	_	_
35	HSF1	HSF1	PROPN	NNP	Number=Sing	_	_	_	_
36	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
37	oligomerization	oligomerization	NOUN	NN	Number=Sing	_	_	_	_
38	of	of	ADP	IN	_	_	_	_	_
39	an	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
40	inert	inert	ADJ	JJ	Degree=Pos	_	_	_	_
41	monomer	monomer	NOUN	NN	Number=Sing	_	_	_	_
42	to	to	ADP	IN	_	_	_	_	_
43	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
44	DNA	dna	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
45	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
46	binding	binding	VERB	VBG	VerbForm=Ger	_	_	_	_
47	trimer	trimer	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
48	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1961
# text = Induction of HSF3 DNA-binding activity is delayed compared with that of HSF1.
1	Induction	Induction	NOUN	NN	Number=Sing	_	_	_	_
2	of	of	ADP	IN	_	_	_	_	_
3	HSF3	HSF3	NUM	CD	NumType=Card	_	_	_	_
4	DNA	dna	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
5	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
6	binding	binding	VERB	VBG	VerbForm=Ger	_	_	_	_
7	activity	activity	NOUN	NN	Number=Sing	_	_	_	_
8	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
9	delayed	delay	ADJ	JJ	Degree=Pos	_	_	_	_
10	compared	compare	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
11	with	with	ADP	IN	_	_	_	_	_
12	that	that	PRON	DT	Number=Sing|PronType=Dem	_	_	_	_
13	of	of	ADP	IN	_	_	_	_	_
14	HSF1	HSF1	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
15	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1962
# text = As occurs for HSF1, heat shock leads to the translocation of HSF3 to the nucleus.
1	As	as	SCONJ	IN	_	_	_	_	_
2	occurs	occur	NOUN	NNS	Number=Plur	_	_	_	_
3	for	for	ADP	IN	_	_	_	_	_
4	HSF1	HSF1	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
5	,	,	PUNCT	,	_	_	_	_	_
6	heat	heat	NOUN	NN	Number=Sing	_	_	_	_
7	shock	shock	NOUN	NN	Number=Sing	_	_	_	_
8	leads	lead	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
9	to	to	ADP	IN	_	_	_	_	_
10	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
11	translocation	translocation	NOUN	NN	Number=Sing	_	_	_	_
12	of	of	ADP	IN	_	_	_	_	_
13	HSF3	HSF3	NUM	CD	NumType=Card	_	_	_	_
14	to	to	ADP	IN	_	_	_	_	_
15	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
16	nucleus	nucleus	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
17	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1963
# text = HSF exhibits the properties of a transcriptional activator, as judged from the stimulatory activity of transiently overexpressed HSF3 measured by using a heat shock element-containing reporter construct and as independently assayed by the activity of a chimeric GAL4-HSF3 protein on a GAL4 reporter construct.
1	HSF	HSF	PRON	PRP	Case=Acc|Number=Sing|Person=1|PronType=Prs|Reflex=Yes	_	_	_	_
2	exhibits	exhibit	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
3	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
4	properties	property	NOUN	NNS	Number=Plur	_	_	_	_
5	of	of	ADP	IN	_	_	_	_	_
6	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
7	transcriptional	transcriptional	ADJ	JJ	Degree=Pos	_	_	_	_
8	activator	activator	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
9	,	,	PUNCT	,	_	_	_	_	_
10	as	as	SCONJ	IN	_	_	_	_	_
11	judged	judge	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
12	from	from	ADP	IN	_	_	_	_	_
13	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
14	stimulatory	stimulatory	ADJ	JJ	Degree=Pos	_	_	_	_
15	activity	activity	NOUN	NN	Number=Sing	_	_	_	_
16	of	of	ADP	IN	_	_	_	_	_
17	transiently	transiently	ADV	RB	_	_	_	_	_
18	overexpressed	overexpress	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
19	HSF3	HSF3	NUM	CD	NumType=Card	_	_	_	_
20	measured	measure	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
21	by	by	SCONJ	IN	_	_	_	_	_
22	using	use	VERB	VBG	VerbForm=Ger	_	_	_	_
23	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
24	heat	heat	NOUN	NN	Number=Sing	_	_	_	_
25	shock	shock	NOUN	NN	Number=Sing	_	_	_	_
26	element	element	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
27	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
28	containing	contain	VERB	VBG	VerbForm=Ger	_	_	_	_
29	reporter	reporter	NOUN	NN	Number=Sing	_	_	_	_
30	construct	construct	NOUN	NN	Number=Sing	_	_	_	_
31	and	and	CCONJ	CC	_	_	_	_	_
32	as	as	SCONJ	IN	_	_	_	_	_
33	independently	independently	ADV	RB	_	_	_	_	_
34	assayed	assay	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
35	by	by	ADP	IN	_	_	_	_	_
36	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
37	activity	activity	NOUN	NN	Number=Sing	_	_	_	_
38	of	of	ADP	IN	_	_	_	_	_
39	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
40	chimeric	chimeric	ADJ	JJ	Degree=Pos	_	_	_	_
41	GAL4	Gal4	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
42	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
43	HSF3	HSF3	NOUN	NN	Number=Sing	_	_	_	_
44	protein	protein	NOUN	NN	Number=Sing	_	_	_	_
45	on	on	ADP	IN	_	_	_	_	_
46	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
47	GAL4	GAL4	PROPN	NNP	Number=Sing	_	_	_	_
48	reporter	reporter	NOUN	NN	Number=Sing	_	_	_	_
49	construct	construct	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
50	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1964
# text = These results reveal that HSF3 is negatively regulated in avian cells and acquires DNA-binding activity in certain cells upon heat shock.
1	These	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
2	results	result	NOUN	NNS	Number=Plur	_	_	_	_
3	reveal	reveal	ADJ	JJ	Degree=Pos	_	_	_	_
4	that	that	SCONJ	IN	_	_	_	_	_
5	HSF3	HSF3	NOUN	NN	Number=Sing	_	_	_	_
6	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
7	negatively	negatively	ADV	RB	_	_	_	_	_
8	regulated	regulate	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
9	in	in	ADP	IN	_	_	_	_	_
10	avian	avian	ADJ	JJ	Degree=Pos	_	_	_	_
11	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
12	and	and	CCONJ	CC	_	_	_	_	_
13	acquires	acquire	NOUN	NNS	Number=Plur	_	_	_	_
14	DNA	dna	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
15	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
16	binding	binding	VERB	VBG	VerbForm=Ger	_	_	_	_
17	activity	activity	NOUN	NN	Number=Sing	_	_	_	_
18	in	in	ADP	IN	_	_	_	_	_
19	certain	certain	ADJ	JJ	Degree=Pos	_	_	_	_
20	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
21	upon	upon	ADP	IN	_	_	_	_	_
22	heat	heat	NOUN	NN	Number=Sing	_	_	_	_
23	shock	shock	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
24	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 1965
# text = Document 00300399 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	00300399	00300399	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 1966
# text = Increased glucocorticoid receptor beta in airway cells of glucocorticoid-insensitive asthma.
1	Increased	increase	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
2	glucocorticoid	glucocorticoid	ADJ	JJ	Degree=Pos	_	_	_	_
3	receptor	receptor	NOUN	NN	Number=Sing	_	_	_	_
4	beta	beta	NOUN	NN	Number=Sing	_	_	_	_
5	in	in	ADP	IN	_	_	_	_	_
6	airway	airway	ADJ	JJ	Degree=Pos	_	_	_	_
7	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
8	of	of	ADP	IN	_	_	_	_	_
9	glucocorticoid	glucocorticoid	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
10	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
11	insensitive	insensitive	ADJ	JJ	Degree=Pos	_	_	_	_
12	asthma	asthma	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
13	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 1967
# text = Glucocorticoid (GC)-insensitive asthma is a challenging clinical problem that can be associated with life-threatening disease progression.
1	Glucocorticoid	Glucocorticoid	PROPN	NNP	Number=Sing	_	_	_	_
2	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
3	GC	GC	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
4	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
5	-	-	PUNCT	:	_	_	_	_	SpaceAfter=No
6	insensitive	insensitive	ADJ	JJ	Degree=Pos	_	_	_	_
7	asthma	asthma	NOUN	NN	Number=Sing	_	_	_	_
8	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
9	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
10	challenging	challenging	ADJ	JJ	Degree=Pos	_	_	_	_
11	clinical	clinical	ADJ	JJ	Degree=Pos	_	_	_	_
12	problem	problem	NOUN	NN	Number=Sing	_	_	_	_
13	that	that	PRON	WDT	PronType=Rel	_	_	_	_
14	can	can	AUX	MD	VerbForm=Fin	_	_	_	_
15	be	be	AUX	VB	VerbForm=Inf	_	_	_	_
16	associated	associate	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
17	with	with	ADP	IN	_	_	_	_	_
18	life	life	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
19	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
20	threatening	threaten	VERB	VBG	VerbForm=Ger	_	_	_	_
21	disease	disease	NOUN	NN	Number=Sing	_	_	_	_
22	progression	progression	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
23	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1968
# text = The molecular basis of GC insensitivity is unknown.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	molecular	molecular	ADJ	JJ	Degree=Pos	_	_	_	_
3	basis	basis	NOUN	NN	Number=Sing	_	_	_	_
4	of	of	ADP	IN	_	_	_	_	_
5	GC	GC	NOUN	NN	Number=Sing	_	_	_	_
6	insensitivity	insensitivity	NOUN	NN	Number=Sing	_	_	_	_
7	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
8	unknown	unknown	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
9	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1969
# text = Alternative splicing of the GC receptor (GCR) pre-mRNA generates a second GCR, termed GCRbeta, which does not bind GC but antagonizes the transactivating activity of the classic GCR.
1	Alternative	alternative	ADJ	JJ	Degree=Pos	_	_	_	_
2	splicing	splicing	NOUN	NN	Number=Sing	_	_	_	_
3	of	of	ADP	IN	_	_	_	_	_
4	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
5	GC	GC	PROPN	NNP	Number=Sing	_	_	_	_
6	receptor	receptor	NOUN	NN	Number=Sing	_	_	_	_
7	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
8	GCR	GCR	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
9	)	)	PUNCT	-RRB-	_	_	_	_	_
10	pre-mRNA	pre-mRNa	PROPN	NNP	Number=Sing	_	_	_	_
11	generates	generate	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
12	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
13	second	second	ADJ	JJ	Degree=Pos|NumType=Ord	_	_	_	_
14	GCR	Gcr	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
15	,	,	PUNCT	,	_	_	_	_	_
16	termed	term	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
17	GCRbeta	GCRbeta	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
18	,	,	PUNCT	,	_	_	_	_	_
19	which	which	PRON	WDT	PronType=Rel	_	_	_	_
20	does	do	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
21	not	not	PART	RB	_	_	_	_	_
22	bind	bind	VERB	VB	VerbForm=Inf	_	_	_	_
23	GC	GC	PROPN	NNP	Number=Sing	_	_	_	_
24	but	but	CCONJ	CC	_	_	_	_	_
25	antagonizes	antagonize	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
26	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
27	transactivating	transactivat	VERB	VBG	VerbForm=Ger	_	_	_	_
28	activity	activity	NOUN	NN	Number=Sing	_	_	_	_
29	of	of	ADP	IN	_	_	_	_	_
30	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
31	classic	classic	ADJ	JJ	Degree=Pos	_	_	_	_
32	GCR	Gcr	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
33	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1970
# text = Thus increased expression of GCRbeta could account for glucocorticoid insensitivity.
1	Thus	thus	ADV	RB	_	_	_	_	_
2	increased	increase	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
3	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
4	of	of	ADP	IN	_	_	_	_	_
5	GCRbeta	GCRbeta	PROPN	NNP	Number=Sing	_	_	_	_
6	could	could	AUX	MD	VerbForm=Fin	_	_	_	_
7	account	account	VERB	VB	VerbForm=Inf	_	_	_	_
8	for	for	ADP	IN	_	_	_	_	_
9	glucocorticoid	glucocorticoid	ADJ	JJ	Degree=Pos	_	_	_	_
10	insensitivity	insensitivity	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
11	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1971
# text = Bronchoalveolar lavage (BAL) cells and peripheral blood mononuclear cells (PBMC) were examined for GCRbeta immunoreactivity using a GCRbeta-specific antibody by immunohistochemical staining.
1	Bronchoalveolar	Bronchoalveolar	ADJ	JJ	Degree=Pos	_	_	_	_
2	lavage	lavage	NOUN	NN	Number=Sing	_	_	_	_
3	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
4	BAL	Bal	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
5	)	)	PUNCT	-RRB-	_	_	_	_	_
6	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
7	and	and	CCONJ	CC	_	_	_	_	_
8	peripheral	peripheral	ADJ	JJ	Degree=Pos	_	_	_	_
9	blood	blood	NOUN	NN	Number=Sing	_	_	_	_
10	mononuclear	mononuclear	ADJ	JJ	Degree=Pos	_	_	_	_
11	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
12	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
13	PBMC	PBMC	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
14	)	)	PUNCT	-RRB-	_	_	_	_	_
15	were	be	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
16	examined	examin	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
17	for	for	ADP	IN	_	_	_	_	_
18	GCRbeta	GCRbeta	PROPN	NNP	Number=Sing	_	_	_	_
19	immunoreactivity	immunoreactivity	NOUN	NN	Number=Sing	_	_	_	_
20	using	use	VERB	VBG	VerbForm=Ger	_	_	_	_
21	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
22	GCRbeta	GCRbeta	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
23	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
24	specific	specific	ADJ	JJ	Degree=Pos	_	_	_	_
25	antibody	antibody	NOUN	NN	Number=Sing	_	_	_	_
26	by	by	ADP	IN	_	_	_	_	_
27	immunohistochemical	immunohistochemical	ADJ	JJ	Degree=Pos	_	_	_	_
28	staining	staining	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
29	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1972
# text = Cell localization of GCRbeta expression was performed using a double immunostaining technique.
1	Cell	cell	NOUN	NN	Number=Sing	_	_	_	_
2	localization	localization	NOUN	NN	Number=Sing	_	_	_	_
3	of	of	ADP	IN	_	_	_	_	_
4	GCRbeta	GCRbeta	PROPN	NNP	Number=Sing	_	_	_	_
5	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
6	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
7	performed	perform	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
8	using	use	VERB	VBG	VerbForm=Ger	_	_	_	_
9	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
10	double	double	NOUN	NN	Number=Sing	_	_	_	_
11	immunostaining	immunostain	VERB	VBG	VerbForm=Ger	_	_	_	_
12	technique	technique	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
13	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1973
# text = Patients with GC-insensitive asthma expressed a significantly higher number of GCRbeta-immunoreactive cells in their BAL and peripheral blood than GC-sensitive asthmatics or normal control subjects.
1	Patients	patient	NOUN	NNS	Number=Plur	_	_	_	_
2	with	with	ADP	IN	_	_	_	_	_
3	GC	GC	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
4	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
5	insensitive	insensitive	ADJ	JJ	Degree=Pos	_	_	_	_
6	asthma	asthma	NOUN	NN	Number=Sing	_	_	_	_
7	expressed	express	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
8	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
9	significantly	significantly	ADV	RB	_	_	_	_	_
10	higher	higher	ADJ	JJR	Degree=Cmp	_	_	_	_
11	number	number	NOUN	NN	Number=Sing	_	_	_	_
12	of	of	ADP	IN	_	_	_	_	_
13	GCRbeta	GCRbeta	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
14	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
15	immunoreactive	immunoreactive	ADJ	JJ	Degree=Pos	_	_	_	_
16	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
17	in	in	ADP	IN	_	_	_	_	_
18	their	they	PRON	PRP$	Number=Plur|Person=3|Poss=Yes|PronType=Prs	_	_	_	_
19	BAL	Bal	NOUN	NN	Number=Sing	_	_	_	_
20	and	and	CCONJ	CC	_	_	_	_	_
21	peripheral	peripheral	ADJ	JJ	Degree=Pos	_	_	_	_
22	blood	blood	NOUN	NN	Number=Sing	_	_	_	_
23	than	than	ADP	IN	_	_	_	_	_
24	GC	GC	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
25	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
26	sensitive	sensitive	ADJ	JJ	Degree=Pos	_	_	_	_
27	asthmatics	asthmatic	NOUN	NNS	Number=Plur	_	_	_	_
28	or	or	CCONJ	CC	_	_	_	_	_
29	normal	normal	ADJ	JJ	Degree=Pos	_	_	_	_
30	control	control	NOUN	NN	Number=Sing	_	_	_	_
31	subjects	subject	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
32	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1974
# text = Furthermore, GCRbeta expression in GC-insensitive asthma was particularly high in airway T cells, which are thought to play a major role in the pathogenesis of asthma.
1	Furthermore	furthermore	ADV	RB	_	_	_	_	SpaceAfter=No
2	,	,	PUNCT	,	_	_	_	_	_
3	GCRbeta	GCRbeta	PROPN	NNP	Number=Sing	_	_	_	_
4	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
5	in	in	ADP	IN	_	_	_	_	_
6	GC	GC	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
7	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
8	insensitive	insensitive	ADJ	JJ	Degree=Pos	_	_	_	_
9	asthma	asthma	NOUN	NN	Number=Sing	_	_	_	_
10	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
11	particularly	particularly	ADV	RB	_	_	_	_	_
12	high	high	ADJ	JJ	Degree=Pos	_	_	_	_
13	in	in	ADP	IN	_	_	_	_	_
14	airway	airway	ADJ	JJ	Degree=Pos	_	_	_	_
15	T	t	PROPN	NNP	Number=Sing	_	_	_	_
16	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
17	,	,	PUNCT	,	_	_	_	_	_
18	which	which	PRON	WDT	PronType=Rel	_	_	_	_
19	are	be	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
20	thought	think	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
21	to	to	PART	TO	_	_	_	_	_
22	play	play	VERB	VB	VerbForm=Inf	_	_	_	_
23	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
24	major	major	ADJ	JJ	Degree=Pos	_	_	_	_
25	role	role	NOUN	NN	Number=Sing	_	_	_	_
26	in	in	ADP	IN	_	_	_	_	_
27	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
28	pathogenesis	pathogenesis	NOUN	NN	Number=Sing	_	_	_	_
29	of	of	ADP	IN	_	_	_	_	_
30	asthma	asthma	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
31	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1975
# text = We also examined the expression of GCRbeta in specimens from the airways of patients with chronic bronchitis.
1	We	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
2	also	also	ADV	RB	_	_	_	_	_
3	examined	examin	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
4	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
5	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
6	of	of	ADP	IN	_	_	_	_	_
7	GCRbeta	GCRbeta	PROPN	NNP	Number=Sing	_	_	_	_
8	in	in	ADP	IN	_	_	_	_	_
9	specimens	specimen	NOUN	NNS	Number=Plur	_	_	_	_
10	from	from	ADP	IN	_	_	_	_	_
11	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
12	airways	airway	NOUN	NNS	Number=Plur	_	_	_	_
13	of	of	ADP	IN	_	_	_	_	_
14	patients	patient	NOUN	NN	Number=Sing	_	_	_	_
15	with	with	ADP	IN	_	_	_	_	_
16	chronic	chronic	ADJ	JJ	Degree=Pos	_	_	_	_
17	bronchitis	bronchitis	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
18	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1976
# text = In chronic bronchitis, few cells were GCRbeta-positive and their numbers did not differ significantly from normal control subjects.
1	In	in	ADP	IN	_	_	_	_	_
2	chronic	chronic	ADJ	JJ	Degree=Pos	_	_	_	_
3	bronchitis	bronchitis	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
4	,	,	PUNCT	,	_	_	_	_	_
5	few	few	ADJ	JJ	Degree=Pos	_	_	_	_
6	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
7	were	be	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
8	GCRbeta	GCRbeta	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
9	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
10	positive	positive	ADJ	JJ	Degree=Pos	_	_	_	_
11	and	and	CCONJ	CC	_	_	_	_	_
12	their	they	PRON	PRP$	Number=Plur|Person=3|Poss=Yes|PronType=Prs	_	_	_	_
13	numbers	number	NOUN	NNS	Number=Plur	_	_	_	_
14	did	do	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
15	not	not	PART	RB	_	_	_	_	_
16	differ	differ	VERB	VB	VerbForm=Inf	_	_	_	_
17	significantly	significantly	ADV	RB	_	_	_	_	_
18	from	from	ADP	IN	_	_	_	_	_
19	normal	normal	ADJ	JJ	Degree=Pos	_	_	_	_
20	control	control	NOUN	NN	Number=Sing	_	_	_	_
21	subjects	subject	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
22	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1977
# text = We conclude that GC-insensitive asthma is associated with increased expression of GCRbeta in airway T cells.
1	We	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
2	conclude	conclude	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
3	that	that	SCONJ	IN	_	_	_	_	_
4	GC	GC	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
5	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
6	insensitive	insensitive	ADJ	JJ	Degree=Pos	_	_	_	_
7	asthma	asthma	NOUN	NN	Number=Sing	_	_	_	_
8	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
9	associated	associate	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
10	with	with	ADP	IN	_	_	_	_	_
11	increased	increase	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
12	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
13	of	of	ADP	IN	_	_	_	_	_
14	GCRbeta	GCRbeta	PROPN	NNP	Number=Sing	_	_	_	_
15	in	in	ADP	IN	_	_	_	_	_
16	airway	airway	PROPN	NNP	Number=Sing	_	_	_	_
17	T	t	PROPN	NNP	Number=Sing	_	_	_	_
18	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
19	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 1978
# text = Document 003003106 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	003003106	003003106	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 1979
# text = Tyrphostin AG-490 inhibits cytokine-mediated JAK3/STAT5a/b signal transduction and cellular proliferation of antigen-activated human T cells.
1	Tyrphostin	Tyrphostin	VERB	VB	Mood=Imp|VerbForm=Fin	_	_	_	_
2	AG	AG	ADV	RB	_	_	_	_	SpaceAfter=No
3	-	-	SYM	SYM	_	_	_	_	SpaceAfter=No
4	490	490	NUM	CD	NumType=Card	_	_	_	_
5	inhibits	inhibit	NOUN	NNS	Number=Plur	_	_	_	_
6	cytokine	cytokine	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
7	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
8	mediated	mediate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
9	JAK3/STAT5	JAK3/STAT5	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
10	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	SpaceAfter=No
11	/	/	PUNCT	,	_	_	_	_	SpaceAfter=No
12	b	benefit	NOUN	NN	Number=Sing	_	_	_	_
13	signal	signal	NOUN	NN	Number=Sing	_	_	_	_
14	transduction	transduction	NOUN	NN	Number=Sing	_	_	_	_
15	and	and	CCONJ	CC	_	_	_	_	_
16	cellular	cellular	ADJ	JJ	Degree=Pos	_	_	_	_
17	proliferation	proliferation	NOUN	NN	Number=Sing	_	_	_	_
18	of	of	ADP	IN	_	_	_	_	_
19	antigen	antigen	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
20	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
21	activated	activate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
22	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
23	T	t	PROPN	NNP	Number=Sing	_	_	_	_
24	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
25	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 1980
# text = Janus kinase 3 (JAK3) is a cytoplasmic tyrosine kinase required for T cell development and activated by cytokines that utilize the interleukin-2 (IL-2) receptor common gamma chain (gamma(c)).
1	Janus	Janus	PROPN	NNP	Number=Sing	_	_	_	_
2	kinase	kinase	NOUN	NN	Number=Sing	_	_	_	_
3	3	3	NUM	CD	NumType=Card	_	_	_	_
4	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
5	JAK3	JAK3	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
6	)	)	PUNCT	-RRB-	_	_	_	_	_
7	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
8	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
9	cytoplasmic	cytoplasmic	ADJ	JJ	Degree=Pos	_	_	_	_
10	tyrosine	tyrosine	NOUN	NN	Number=Sing	_	_	_	_
11	kinase	kinase	NOUN	NN	Number=Sing	_	_	_	_
12	required	require	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
13	for	for	ADP	IN	_	_	_	_	_
14	T	t	PROPN	NNP	Number=Sing	_	_	_	_
15	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
16	development	development	NOUN	NN	Number=Sing	_	_	_	_
17	and	and	CCONJ	CC	_	_	_	_	_
18	activated	activate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
19	by	by	ADP	IN	_	_	_	_	_
20	cytokines	cytokine	NOUN	NNS	Number=Plur	_	_	_	_
21	that	that	PRON	WDT	PronType=Rel	_	_	_	_
22	utilize	utilize	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
23	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
24	interleukin	interleukin	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
25	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
26	2	2	NUM	CD	NumType=Card	_	_	_	_
27	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
28	IL	Il	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
29	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
30	2	2	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
31	)	)	PUNCT	-RRB-	_	_	_	_	_
32	receptor	receptor	NOUN	NN	Number=Sing	_	_	_	_
33	common	common	ADJ	JJ	Degree=Pos	_	_	_	_
34	gamma	gamma	NOUN	NN	Number=Sing	_	_	_	_
35	chain	chain	NOUN	NN	Number=Sing	_	_	_	_
36	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
37	gamma	gamma	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
38	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
39	c	c	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
40	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
41	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
42	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1981
# text = Genetic inactivation of JAK3 is manifested as severe combined immunodeficiency disease (SCID) in humans and mice.
1	Genetic	genetic	ADJ	JJ	Degree=Pos	_	_	_	_
2	inactivation	inactivation	NOUN	NN	Number=Sing	_	_	_	_
3	of	of	ADP	IN	_	_	_	_	_
4	JAK3	JAK3	NUM	CD	NumType=Card	_	_	_	_
5	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
6	manifested	manifest	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
7	as	as	ADP	IN	_	_	_	_	_
8	severe	severe	ADJ	JJ	Degree=Pos	_	_	_	_
9	combined	combine	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
10	immunodeficiency	immunodeficiency	NOUN	NN	Number=Sing	_	_	_	_
11	disease	disease	NOUN	NN	Number=Sing	_	_	_	_
12	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
13	SCID	SCID	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
14	)	)	PUNCT	-RRB-	_	_	_	_	_
15	in	in	ADP	IN	_	_	_	_	_
16	humans	human	NOUN	NNS	Number=Plur	_	_	_	_
17	and	and	CCONJ	CC	_	_	_	_	_
18	mice	mouse	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
19	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1982
# text = These findings have suggested that JAK3 represents a pharmacological target to control certain lymphoid-derived diseases.
1	These	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
2	findings	finding	NOUN	NNS	Number=Plur	_	_	_	_
3	have	have	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
4	suggested	suggest	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
5	that	that	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
6	JAK3	JAK3	NOUN	NN	Number=Sing	_	_	_	_
7	represents	represent	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
8	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
9	pharmacological	pharmacological	ADJ	JJ	Degree=Pos	_	_	_	_
10	target	target	NOUN	NN	Number=Sing	_	_	_	_
11	to	to	PART	TO	_	_	_	_	_
12	control	control	VERB	VB	VerbForm=Inf	_	_	_	_
13	certain	certain	ADJ	JJ	Degree=Pos	_	_	_	_
14	lymphoid	lymphoid	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
15	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
16	derived	derive	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
17	diseases	diseasis	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
18	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1983
# text = Here we provide novel evidence that AG-490 potently inhibits the autokinase activity of JAK3 and tyrosine phosphorylation and DNA binding of signal transducer and activator of transcription 5a and 5b (STAT5a/b).
1	Here	here	ADV	RB	PronType=Dem	_	_	_	_
2	we	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
3	provide	provide	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
4	novel	novel	ADJ	JJ	Degree=Pos	_	_	_	_
5	evidence	evidence	NOUN	NN	Number=Sing	_	_	_	_
6	that	that	SCONJ	IN	_	_	_	_	_
7	AG	AG	VERB	VBG	VerbForm=Ger	_	_	_	SpaceAfter=No
8	-	-	SYM	SYM	_	_	_	_	SpaceAfter=No
9	490	490	NUM	CD	NumType=Card	_	_	_	_
10	potently	potently	ADV	RB	_	_	_	_	_
11	inhibits	inhibits	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
12	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
13	autokinase	autokinase	ADJ	JJ	Degree=Pos	_	_	_	_
14	activity	activity	NOUN	NN	Number=Sing	_	_	_	_
15	of	of	ADP	IN	_	_	_	_	_
16	JAK3	JAK3	NUM	CD	NumType=Card	_	_	_	_
17	and	and	CCONJ	CC	_	_	_	_	_
18	tyrosine	tyrosine	NOUN	NN	Number=Sing	_	_	_	_
19	phosphorylation	phosphorylation	NOUN	NN	Number=Sing	_	_	_	_
20	and	and	CCONJ	CC	_	_	_	_	_
21	DNA	dna	NOUN	NN	Number=Sing	_	_	_	_
22	binding	binding	VERB	VBG	VerbForm=Ger	_	_	_	_
23	of	of	ADP	IN	_	_	_	_	_
24	signal	signal	NOUN	NN	Number=Sing	_	_	_	_
25	transducer	transducer	NOUN	NN	Number=Sing	_	_	_	_
26	and	and	CCONJ	CC	_	_	_	_	_
27	activator	activator	NOUN	NN	Number=Sing	_	_	_	_
28	of	of	ADP	IN	_	_	_	_	_
29	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
30	5	5	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
31	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
32	and	and	CCONJ	CC	_	_	_	_	_
33	5	5	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
34	b	b	NOUN	NN	Number=Sing	_	_	_	_
35	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
36	STAT5	STAT5	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
37	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	SpaceAfter=No
38	/	/	PUNCT	,	_	_	_	_	SpaceAfter=No
39	b	b	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
40	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
41	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1984
# text = Similar inhibitory effects were observed with other cytokines that use gamma(c).
1	Similar	similar	ADJ	JJ	Degree=Pos	_	_	_	_
2	inhibitory	inhibitory	NOUN	NN	Number=Sing	_	_	_	_
3	effects	effect	NOUN	NNS	Number=Plur	_	_	_	_
4	were	be	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
5	observed	observe	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
6	with	with	ADP	IN	_	_	_	_	_
7	other	other	ADJ	JJ	Degree=Pos	_	_	_	_
8	cytokines	cytokine	NOUN	NNS	Number=Plur	_	_	_	_
9	that	that	PRON	WDT	PronType=Rel	_	_	_	_
10	use	use	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
11	gamma	gamma	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
12	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
13	c	c	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
14	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
15	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1985
# text = AG-490 also inhibited IL-2-mediated proliferative growth in human T cells with an IC50) = 25 microM that was partially recoverable.
1	AG	ag	INTJ	UH	_	_	_	_	SpaceAfter=No
2	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
3	490	490	NUM	CD	NumType=Card	_	_	_	_
4	also	also	ADV	RB	_	_	_	_	_
5	inhibited	inhibit	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
6	IL	il	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
7	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
8	2	2	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
9	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
10	mediated	mediate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
11	proliferative	proliferative	ADJ	JJ	Degree=Pos	_	_	_	_
12	growth	growth	NOUN	NN	Number=Sing	_	_	_	_
13	in	in	ADP	IN	_	_	_	_	_
14	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
15	T	t	PROPN	NNP	Number=Sing	_	_	_	_
16	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
17	with	with	ADP	IN	_	_	_	_	_
18	an	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
19	IC50	IC50	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
20	)	)	PUNCT	-RRB-	_	_	_	_	_
21	=	=	SYM	SYM	_	_	_	_	_
22	25	25	NUM	CD	NumType=Card	_	_	_	_
23	microM	microm	NOUN	NN	Number=Sing	_	_	_	_
24	that	that	PRON	WDT	PronType=Rel	_	_	_	_
25	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
26	partially	partially	ADV	RB	_	_	_	_	_
27	recoverable	recoverable	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
28	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1986
# text = Moreover, we demonstrate that this inhibitor prevented tetanus toxoid antigen-specific T cell proliferation and expansion but failed to block activation of Zap70 or p56Lck after anti-CD3 stimulation of human T cells.
1	Moreover	moreover	ADV	RB	_	_	_	_	SpaceAfter=No
2	,	,	PUNCT	,	_	_	_	_	_
3	we	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
4	demonstrate	demonstrate	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
5	that	that	SCONJ	IN	_	_	_	_	_
6	this	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
7	inhibitor	inhibitor	NOUN	NN	Number=Sing	_	_	_	_
8	prevented	prevent	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
9	tetanus	tetanus	ADP	IN	_	_	_	_	_
10	toxoid	toxoid	ADJ	JJ	Degree=Pos	_	_	_	_
11	antigen-specific	antigen-specific	ADJ	JJ	Degree=Pos	_	_	_	_
12	T	t	PROPN	NNP	Number=Sing	_	_	_	_
13	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
14	proliferation	proliferation	NOUN	NN	Number=Sing	_	_	_	_
15	and	and	CCONJ	CC	_	_	_	_	_
16	expansion	expansion	NOUN	NN	Number=Sing	_	_	_	_
17	but	but	CCONJ	CC	_	_	_	_	_
18	failed	fail	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
19	to	to	PART	TO	_	_	_	_	_
20	block	block	VERB	VB	VerbForm=Inf	_	_	_	_
21	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
22	of	of	ADP	IN	_	_	_	_	_
23	Zap70	Zap70	PROPN	NNP	Number=Sing	_	_	_	_
24	or	or	CCONJ	CC	_	_	_	_	_
25	p56Lck	p56Lck	PROPN	NNP	Number=Sing	_	_	_	_
26	after	after	ADP	IN	_	_	_	_	_
27	anti-CD3	anti-CD3	NUM	CD	NumType=Card	_	_	_	_
28	stimulation	stimulation	NOUN	NN	Number=Sing	_	_	_	_
29	of	of	ADP	IN	_	_	_	_	_
30	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
31	T	t	PROPN	NNP	Number=Sing	_	_	_	_
32	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
33	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1987
# text = Taken together, these findings suggest that AG-490 inhibits the JAK3-mediated Type II signaling pathway but not the T cell receptor-derived Type I pathway and possesses therapeutic potential for T cell-derived pathologies such as graft-versus-host disease, allergy, and autoimmune disorders.
1	Taken	take	PROPN	NNP	Number=Sing	_	_	_	_
2	together	together	ADV	RB	_	_	_	_	SpaceAfter=No
3	,	,	PUNCT	,	_	_	_	_	_
4	these	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
5	findings	finding	NOUN	NNS	Number=Plur	_	_	_	_
6	suggest	suggest	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
7	that	that	SCONJ	IN	_	_	_	_	_
8	AG	AG	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
9	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
10	490	490	NUM	CD	NumType=Card	_	_	_	_
11	inhibits	inhibit	NOUN	NNS	Number=Plur	_	_	_	_
12	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
13	JAK3	JAK3	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
14	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
15	mediated	mediate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
16	Type	type	NOUN	NN	Number=Sing	_	_	_	_
17	II	ii	NUM	CD	NumType=Card	_	_	_	_
18	signaling	signal	NOUN	NN	Number=Sing	_	_	_	_
19	pathway	pathway	NOUN	NN	Number=Sing	_	_	_	_
20	but	but	CCONJ	CC	_	_	_	_	_
21	not	not	PART	RB	_	_	_	_	_
22	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
23	T	T	PROPN	NNP	Number=Sing	_	_	_	_
24	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
25	receptor	receptor	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
26	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
27	derived	derived	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
28	Type	type	NOUN	NN	Number=Sing	_	_	_	_
29	I	I	PRON	PRP	Case=Nom|Number=Sing|Person=1|PronType=Prs	_	_	_	_
30	pathway	pathway	NOUN	NN	Number=Sing	_	_	_	_
31	and	and	CCONJ	CC	_	_	_	_	_
32	possesses	possess	NOUN	NNS	Number=Plur	_	_	_	_
33	therapeutic	therapeutic	ADJ	JJ	Degree=Pos	_	_	_	_
34	potential	potential	NOUN	NN	Number=Sing	_	_	_	_
35	for	for	ADP	IN	_	_	_	_	_
36	T	t	PROPN	NNP	Number=Sing	_	_	_	_
37	cell	cell	ADV	RB	Degree=Pos	_	_	_	SpaceAfter=No
38	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
39	derived	derive	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
40	pathologies	pathology	NOUN	NNS	Number=Plur	_	_	_	_
41	such	such	ADJ	JJ	Degree=Pos	_	_	_	_
42	as	as	ADP	IN	_	_	_	_	_
43	graft	graft	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
44	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
45	versus	versus	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
46	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
47	host	host	NOUN	NN	Number=Sing	_	_	_	_
48	disease	disease	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
49	,	,	PUNCT	,	_	_	_	_	_
50	allergy	allergy	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
51	,	,	PUNCT	,	_	_	_	_	_
52	and	and	CCONJ	CC	_	_	_	_	_
53	autoimmune	autoimmune	ADJ	JJ	Degree=Pos	_	_	_	_
54	disorders	disorder	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
55	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 1988
# text = Document 003003107 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	003003107	003003107	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 1989
# text = Inhibition of T cell activation by the extracellular matrix protein tenascin.
1	Inhibition	Inhibition	NOUN	NN	Number=Sing	_	_	_	_
2	of	of	ADP	IN	_	_	_	_	_
3	T	t	PROPN	NNP	Number=Sing	_	_	_	_
4	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
5	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
6	by	by	ADP	IN	_	_	_	_	_
7	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
8	extracellular	extracellular	ADJ	JJ	Degree=Pos	_	_	_	_
9	matrix	matrix	NOUN	NN	Number=Sing	_	_	_	_
10	protein	protein	NOUN	NN	Number=Sing	_	_	_	_
11	tenascin	tenascin	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
12	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 1990
# text = Tenascin (TN) is an extracellular matrix protein that is expressed widely in the fetus and sparingly in the adult, but reappears at high levels in certain areas of tissue insult such as tumor matrices and sites of wound healing.
1	Tenascin	Tenascin	PROPN	NNP	Number=Sing	_	_	_	_
2	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
3	TN	TN	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
4	)	)	PUNCT	-RRB-	_	_	_	_	_
5	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
6	an	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
7	extracellular	extracellular	ADJ	JJ	Degree=Pos	_	_	_	_
8	matrix	matrix	NOUN	NN	Number=Sing	_	_	_	_
9	protein	protein	NOUN	NN	Number=Sing	_	_	_	_
10	that	that	PRON	WDT	PronType=Rel	_	_	_	_
11	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
12	expressed	express	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
13	widely	widely	ADV	RB	_	_	_	_	_
14	in	in	ADP	IN	_	_	_	_	_
15	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
16	fetus	fetus	NOUN	NN	Number=Sing	_	_	_	_
17	and	and	CCONJ	CC	_	_	_	_	_
18	sparingly	sparingly	ADV	RB	_	_	_	_	_
19	in	in	ADP	IN	_	_	_	_	_
20	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
21	adult	adult	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
22	,	,	PUNCT	,	_	_	_	_	_
23	but	but	CCONJ	CC	_	_	_	_	_
24	reappears	reappear	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
25	at	at	ADP	IN	_	_	_	_	_
26	high	high	ADJ	JJ	Degree=Pos	_	_	_	_
27	levels	level	NOUN	NNS	Number=Plur	_	_	_	_
28	in	in	ADP	IN	_	_	_	_	_
29	certain	certain	ADJ	JJ	Degree=Pos	_	_	_	_
30	areas	area	NOUN	NNS	Number=Plur	_	_	_	_
31	of	of	ADP	IN	_	_	_	_	_
32	tissue	tissue	NOUN	NN	Number=Sing	_	_	_	_
33	insult	insult	NOUN	NN	Number=Sing	_	_	_	_
34	such	such	ADJ	JJ	Degree=Pos	_	_	_	_
35	as	as	ADP	IN	_	_	_	_	_
36	tumor	tumor	NOUN	NN	Number=Sing	_	_	_	_
37	matrices	matrice	NOUN	NNS	Number=Plur	_	_	_	_
38	and	and	CCONJ	CC	_	_	_	_	_
39	sites	site	NOUN	NNS	Number=Plur	_	_	_	_
40	of	of	ADP	IN	_	_	_	_	_
41	wound	wound	ADJ	JJ	Degree=Pos	_	_	_	_
42	healing	healing	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
43	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1991
# text = We show here that soluble TN inhibits proliferation of human T cells in response to alpha CD3
1	We	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
2	show	show	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
3	here	here	ADV	RB	PronType=Dem	_	_	_	_
4	that	that	SCONJ	IN	_	_	_	_	_
5	soluble	soluble	ADJ	JJ	Degree=Pos	_	_	_	_
6	TN	Tn	NOUN	NN	Number=Sing	_	_	_	_
7	inhibits	inhibits	NOUN	NNS	Number=Plur	_	_	_	_
8	proliferation	proliferation	NOUN	NN	Number=Sing	_	_	_	_
9	of	of	ADP	IN	_	_	_	_	_
10	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
11	T	t	PROPN	NNP	Number=Sing	_	_	_	_
12	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
13	in	in	ADP	IN	_	_	_	_	_
14	response	response	NOUN	NN	Number=Sing	_	_	_	_
15	to	to	ADP	IN	_	_	_	_	_
16	alpha	alpha	NOUN	NN	Number=Sing	_	_	_	_
17	CD3	CD3	NOUN	NN	Number=Sing	_	_	_	_

# sent_id = 1992
# text = Ab co-immobilized with the extracellular matrix protein fibronectin (FN).
1	Ab	Ab	PROPN	NNP	Number=Sing	_	_	_	_
2	co-immobilized	co-immobilize	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
3	with	with	ADP	IN	_	_	_	_	_
4	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
5	extracellular	extracellular	ADJ	JJ	Degree=Pos	_	_	_	_
6	matrix	matrix	NOUN	NN	Number=Sing	_	_	_	_
7	protein	protein	NOUN	NN	Number=Sing	_	_	_	_
8	fibronectin	fibronectin	NOUN	NN	Number=Sing	_	_	_	_
9	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
10	FN	FN	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
11	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
12	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1993
# text = TN also inhibits proliferation driven by alpha CD3/IL-2 or by phorbol ester/IL-2, and it prevents high level induction of IL-2R.
1	TN	rn	PROPN	NNP	Number=Sing	_	_	_	_
2	also	also	ADV	RB	_	_	_	_	_
3	inhibits	inhibits	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
4	proliferation	proliferation	NOUN	NN	Number=Sing	_	_	_	_
5	driven	drive	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
6	by	by	ADP	IN	_	_	_	_	_
7	alpha	alpha	NOUN	NN	Number=Sing	_	_	_	_
8	CD3/IL	Cd3/il	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
9	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
10	2	2	NUM	CD	NumType=Card	_	_	_	_
11	or	or	CCONJ	CC	_	_	_	_	_
12	by	by	ADP	IN	_	_	_	_	_
13	phorbol	phorbol	NOUN	NN	Number=Sing	_	_	_	_
14	ester/IL	ester/il	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
15	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
16	2	2	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
17	,	,	PUNCT	,	_	_	_	_	_
18	and	and	CCONJ	CC	_	_	_	_	_
19	it	it	PRON	PRP	Case=Nom|Gender=Neut|Number=Sing|Person=3|PronType=Prs	_	_	_	_
20	prevents	prevent	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
21	high	high	ADJ	JJ	Degree=Pos	_	_	_	_
22	level	level	NOUN	NN	Number=Sing	_	_	_	_
23	induction	induction	NOUN	NN	Number=Sing	_	_	_	_
24	of	of	ADP	IN	_	_	_	_	_
25	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
26	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
27	2R	2R	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
28	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1994
# text = The presence of TN in culture medium does not detectably alter the pattern of tyrosine phosphorylation resulting from T cell triggering with alpha CD3, but at later time points prevents the appearance of functional NF-AT1 transcription factor complexes in T cell nuclear extracts.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	presence	presence	NOUN	NN	Number=Sing	_	_	_	_
3	of	of	ADP	IN	_	_	_	_	_
4	TN	rn	PROPN	NNP	Number=Sing	_	_	_	_
5	in	in	ADP	IN	_	_	_	_	_
6	culture	culture	NOUN	NN	Number=Sing	_	_	_	_
7	medium	medium	NOUN	NN	Number=Sing	_	_	_	_
8	does	do	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
9	not	not	PART	RB	_	_	_	_	_
10	detectably	detectably	ADV	RB	_	_	_	_	_
11	alter	alter	VERB	VB	VerbForm=Inf	_	_	_	_
12	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
13	pattern	pattern	NOUN	NN	Number=Sing	_	_	_	_
14	of	of	ADP	IN	_	_	_	_	_
15	tyrosine	tyrosine	NOUN	NN	Number=Sing	_	_	_	_
16	phosphorylation	phosphorylation	NOUN	NN	Number=Sing	_	_	_	_
17	resulting	result	VERB	VBG	VerbForm=Ger	_	_	_	_
18	from	from	ADP	IN	_	_	_	_	_
19	T	T	PROPN	NNP	Number=Sing	_	_	_	_
20	cell	cell	PROPN	NNP	Number=Sing	_	_	_	_
21	triggering	trigger	VERB	VBG	VerbForm=Ger	_	_	_	_
22	with	with	ADP	IN	_	_	_	_	_
23	alpha	alpha	NOUN	NN	Number=Sing	_	_	_	_
24	CD3	CD3	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
25	,	,	PUNCT	,	_	_	_	_	_
26	but	but	CCONJ	CC	_	_	_	_	_
27	at	at	ADP	IN	_	_	_	_	_
28	later	later	ADJ	JJR	Degree=Cmp	_	_	_	_
29	time	time	NOUN	NN	Number=Sing	_	_	_	_
30	points	point	NOUN	NNS	Number=Plur	_	_	_	_
31	prevents	prevent	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
32	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
33	appearance	appearance	NOUN	NN	Number=Sing	_	_	_	_
34	of	of	ADP	IN	_	_	_	_	_
35	functional	functional	ADJ	JJ	Degree=Pos	_	_	_	_
36	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
37	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
38	AT1	AT1	PROPN	NNP	Number=Sing	_	_	_	_
39	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
40	factor	factor	NOUN	NN	Number=Sing	_	_	_	_
41	complexes	complex	NOUN	NNS	Number=Plur	_	_	_	_
42	in	in	ADP	IN	_	_	_	_	_
43	T	t	PROPN	NNP	Number=Sing	_	_	_	_
44	cell	cell	PROPN	NNP	Number=Sing	_	_	_	_
45	nuclear	nuclear	ADJ	JJ	Degree=Pos	_	_	_	_
46	extracts	extract	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
47	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1995
# text = These findings are consistent with the postulated role for TN as a natural antagonist to FN action, and suggest that T cell responses occurring at tissue sites in which TN is expressed could be influenced by its presence.
1	These	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
2	findings	finding	NOUN	NNS	Number=Plur	_	_	_	_
3	are	be	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
4	consistent	consistent	ADJ	JJ	Degree=Pos	_	_	_	_
5	with	with	ADP	IN	_	_	_	_	_
6	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
7	postulated	postulate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
8	role	role	NOUN	NN	Number=Sing	_	_	_	_
9	for	for	ADP	IN	_	_	_	_	_
10	TN	TN	PROPN	NNP	Number=Sing	_	_	_	_
11	as	as	ADP	IN	_	_	_	_	_
12	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
13	natural	natural	ADJ	JJ	Degree=Pos	_	_	_	_
14	antagonist	antagonist	NOUN	NN	Number=Sing	_	_	_	_
15	to	to	PART	TO	_	_	_	_	_
16	FN	Fn	VERB	VB	VerbForm=Inf	_	_	_	_
17	action	action	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
18	,	,	PUNCT	,	_	_	_	_	_
19	and	and	CCONJ	CC	_	_	_	_	_
20	suggest	suggest	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
21	that	that	SCONJ	IN	_	_	_	_	_
22	T	t	PROPN	NNP	Number=Sing	_	_	_	_
23	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
24	responses	response	NOUN	NNS	Number=Plur	_	_	_	_
25	occurring	occurre	VERB	VBG	VerbForm=Ger	_	_	_	_
26	at	at	ADP	IN	_	_	_	_	_
27	tissue	tissue	NOUN	NN	Number=Sing	_	_	_	_
28	sites	site	NOUN	NNS	Number=Plur	_	_	_	_
29	in	in	ADP	IN	_	_	_	_	_
30	which	which	PRON	WDT	PronType=Rel	_	_	_	_
31	TN	TN	PROPN	NNP	Number=Sing	_	_	_	_
32	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
33	expressed	express	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
34	could	could	AUX	MD	VerbForm=Fin	_	_	_	_
35	be	be	AUX	VB	VerbForm=Inf	_	_	_	_
36	influenced	influence	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
37	by	by	ADP	IN	_	_	_	_	_
38	its	its	PRON	PRP$	Gender=Neut|Number=Sing|Person=3|Poss=Yes|PronType=Prs	_	_	_	_
39	presence	presence	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
40	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 1996
# text = Document 003003108 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	003003108	003003108	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 1997
# text = CBP/p300 integrates Raf/Rac-signaling pathways in the transcriptional induction of NF-ATc during T cell activation.
1	CBP	CBp	SYM	NFP	_	_	_	_	SpaceAfter=No
2	/	/	SYM	SYM	_	_	_	_	SpaceAfter=No
3	p300	p300	NUM	CD	NumType=Card	_	_	_	_
4	integrates	integrate	NOUN	NNS	Number=Plur	_	_	_	_
5	Raf	Raf	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
6	/	/	PUNCT	,	_	_	_	_	SpaceAfter=No
7	Rac	rac	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
8	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
9	signaling	signal	VERB	VBG	VerbForm=Ger	_	_	_	_
10	pathways	pathway	NOUN	NNS	Number=Plur	_	_	_	_
11	in	in	ADP	IN	_	_	_	_	_
12	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
13	transcriptional	transcriptional	ADJ	JJ	Degree=Pos	_	_	_	_
14	induction	induction	NOUN	NN	Number=Sing	_	_	_	_
15	of	of	ADP	IN	_	_	_	_	_
16	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
17	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
18	ATc	ATc	PROPN	NNP	Number=Sing	_	_	_	_
19	during	during	ADP	IN	_	_	_	_	_
20	T	t	PROPN	NNP	Number=Sing	_	_	_	_
21	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
22	activation	activation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
23	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 1998
# text = NF-ATc, an inducibly expressed transcription factor, controls gene expression in T lymphocytes and cardiomyocytes.
1	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
2	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
3	ATc	ATc	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
4	,	,	PUNCT	,	_	_	_	_	_
5	an	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
6	inducibly	inducibly	ADV	RB	_	_	_	_	_
7	expressed	express	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
8	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
9	factor	factor	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
10	,	,	PUNCT	,	_	_	_	_	_
11	controls	control	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
12	gene	gene	ADJ	JJ	Degree=Pos	_	_	_	_
13	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
14	in	in	ADP	IN	_	_	_	_	_
15	T	t	PROPN	NNP	Number=Sing	_	_	_	_
16	lymphocytes	lymphocyte	NOUN	NNS	Number=Plur	_	_	_	_
17	and	and	CCONJ	CC	_	_	_	_	_
18	cardiomyocytes	cardiomyocyte	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
19	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 1999
# text = We show here that the transcriptional co-activators CBP/p300 bind to and control the activity of the inducible N-terminal transactivation domain of NF-ATc, TAD-A.
1	We	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
2	show	show	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
3	here	here	ADV	RB	PronType=Dem	_	_	_	_
4	that	that	SCONJ	IN	_	_	_	_	_
5	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
6	transcriptional	transcriptional	ADJ	JJ	Degree=Pos	_	_	_	_
7	co-activators	co-activator	NOUN	NNS	Number=Plur	_	_	_	_
8	CBP	Cbp	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
9	/	/	PUNCT	,	_	_	_	_	SpaceAfter=No
10	p300	p300	NUM	CD	NumType=Card	_	_	_	_
11	bind	bind	NOUN	NN	Number=Sing	_	_	_	_
12	to	to	PART	TO	_	_	_	_	_
13	and	and	CCONJ	CC	_	_	_	_	_
14	control	control	VERB	VB	VerbForm=Inf	_	_	_	_
15	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
16	activity	activity	NOUN	NN	Number=Sing	_	_	_	_
17	of	of	ADP	IN	_	_	_	_	_
18	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
19	inducible	inducible	ADJ	JJ	Degree=Pos	_	_	_	_
20	N-	N-	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
21	terminal	terminal	NOUN	NN	Number=Sing	_	_	_	_
22	transactivation	transactivation	NOUN	NN	Number=Sing	_	_	_	_
23	domain	domain	NOUN	NN	Number=Sing	_	_	_	_
24	of	of	ADP	IN	_	_	_	_	_
25	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
26	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
27	ATc	ATc	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
28	,	,	PUNCT	,	_	_	_	_	_
29	TAD	TAD	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
30	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
31	A	A	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
32	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2000
# text = Similar to the N terminal transactivation domain of c-Jun, TAD-A is inducibly phosphorylated, but this phosphorylation is dispensable for the interaction with CBP/p300.
1	Similar	similar	ADJ	JJ	Degree=Pos	_	_	_	_
2	to	to	ADP	IN	_	_	_	_	_
3	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
4	N	N	PROPN	NNP	Number=Sing	_	_	_	_
5	terminal	terminal	ADJ	JJ	Degree=Pos	_	_	_	_
6	transactivation	transactivation	NOUN	NN	Number=Sing	_	_	_	_
7	domain	domain	NOUN	NN	Number=Sing	_	_	_	_
8	of	of	ADP	IN	_	_	_	_	_
9	c	c	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
10	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
11	Jun	Jun	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
12	,	,	PUNCT	,	_	_	_	_	_
13	TAD	TAD	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
14	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
15	A	a	PROPN	NNP	Number=Sing	_	_	_	_
16	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
17	inducibly	inducibly	ADV	RB	_	_	_	_	_
18	phosphorylated	phosphorylate	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	SpaceAfter=No
19	,	,	PUNCT	,	_	_	_	_	_
20	but	but	CCONJ	CC	_	_	_	_	_
21	this	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
22	phosphorylation	phosphorylation	NOUN	NN	Number=Sing	_	_	_	_
23	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
24	dispensable	dispensable	ADJ	JJ	Degree=Pos	_	_	_	_
25	for	for	ADP	IN	_	_	_	_	_
26	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
27	interaction	interaction	NOUN	NN	Number=Sing	_	_	_	_
28	with	with	ADP	IN	_	_	_	_	_
29	CBP	CBP	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
30	/	/	PUNCT	,	_	_	_	_	SpaceAfter=No
31	p300	p300	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
32	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2001
# text = Constitutive active versions of c-Raf and Rac synergistically enhance the CBP/p300-mediated increase of TAD-A activity, indicating the important role CBP/p300 plays in the integration of T cell activation signals.
1	Constitutive	Constitutive	ADJ	JJ	Degree=Pos	_	_	_	_
2	active	active	ADJ	JJ	Degree=Pos	_	_	_	_
3	versions	version	NOUN	NNS	Number=Plur	_	_	_	_
4	of	of	ADP	IN	_	_	_	_	_
5	c	c	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
6	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
7	Raf	Raf	PROPN	NNP	Number=Sing	_	_	_	_
8	and	and	CCONJ	CC	_	_	_	_	_
9	Rac	rac	PROPN	NNP	Number=Sing	_	_	_	_
10	synergistically	synergistically	ADV	RB	_	_	_	_	_
11	enhance	enhance	VERB	VB	Mood=Imp|VerbForm=Fin	_	_	_	_
12	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
13	CBP	CBP	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
14	/	/	PUNCT	,	_	_	_	_	SpaceAfter=No
15	p300	p300	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
16	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
17	mediated	mediate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
18	increase	increase	NOUN	NN	Number=Sing	_	_	_	_
19	of	of	ADP	IN	_	_	_	_	_
20	TAD	TAD	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
21	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
22	A	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
23	activity	activity	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
24	,	,	PUNCT	,	_	_	_	_	_
25	indicating	indicate	VERB	VBG	VerbForm=Ger	_	_	_	_
26	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
27	important	important	ADJ	JJ	Degree=Pos	_	_	_	_
28	role	role	NOUN	NN	Number=Sing	_	_	_	_
29	CBP	Cbp	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
30	/	/	PUNCT	,	_	_	_	_	SpaceAfter=No
31	p300	p300	NUM	CD	NumType=Card	_	_	_	_
32	plays	play	NOUN	NNS	Number=Plur	_	_	_	_
33	in	in	ADP	IN	_	_	_	_	_
34	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
35	integration	integration	NOUN	NN	Number=Sing	_	_	_	_
36	of	of	ADP	IN	_	_	_	_	_
37	T	t	PROPN	NNP	Number=Sing	_	_	_	_
38	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
39	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
40	signals	signal	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
41	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2002
# text = Since a mutation of CBP abolishing HAT activity is almost as active as wild-type CBP in T cells, functions of CBP/p300 other than histone acetylation appear to control the NF-AT-dependent transcription in T cells.
1	Since	since	ADP	IN	_	_	_	_	_
2	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
3	mutation	mutation	NOUN	NN	Number=Sing	_	_	_	_
4	of	of	ADP	IN	_	_	_	_	_
5	CBP	CBP	PROPN	NNP	Number=Sing	_	_	_	_
6	abolishing	abolish	VERB	VBG	VerbForm=Ger	_	_	_	_
7	HAT	hat	DET	WDT	PronType=Int	_	_	_	_
8	activity	activity	NOUN	NN	Number=Sing	_	_	_	_
9	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
10	almost	almost	ADV	RB	_	_	_	_	_
11	as	as	ADV	RB	_	_	_	_	_
12	active	active	ADJ	JJ	Degree=Pos	_	_	_	_
13	as	as	ADP	IN	_	_	_	_	_
14	wild	wild	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
15	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
16	type	type	NOUN	NN	Number=Sing	_	_	_	_
17	CBP	Cbp	NOUN	NN	Number=Sing	_	_	_	_
18	in	in	ADP	IN	_	_	_	_	_
19	T	t	PROPN	NNP	Number=Sing	_	_	_	_
20	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
21	,	,	PUNCT	,	_	_	_	_	_
22	functions	function	NOUN	NNS	Number=Plur	_	_	_	_
23	of	of	ADP	IN	_	_	_	_	_
24	CBP	CBP	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
25	/	/	PUNCT	,	_	_	_	_	SpaceAfter=No
26	p300	p300	NUM	CD	NumType=Card	_	_	_	_
27	other	other	ADJ	JJ	Degree=Pos	_	_	_	_
28	than	than	ADP	IN	_	_	_	_	_
29	histone	histone	PRON	NN	Number=Sing	_	_	_	_
30	acetylation	acetylation	NOUN	NN	Number=Sing|Typo=Yes	_	_	_	_
31	appear	appear	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
32	to	to	PART	TO	_	_	_	_	_
33	control	control	VERB	VB	VerbForm=Inf	_	_	_	_
34	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
35	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
36	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
37	AT	AT	ADV	RB	_	_	_	_	SpaceAfter=No
38	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
39	dependent	dependent	ADJ	JJ	Degree=Pos	_	_	_	_
40	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
41	in	in	ADP	IN	_	_	_	_	_
42	T	t	PROPN	NNP	Number=Sing	_	_	_	_
43	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
44	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 2003
# text = Document 003003114 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	003003114	003003114	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 2004
# text = Bik, a novel death-inducing protein shares a distinct sequence motif with Bcl-2 family proteins and interacts with viral and cellular survival-promoting proteins.
1	Bik	Bik	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
2	,	,	PUNCT	,	_	_	_	_	_
3	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
4	novel	novel	NOUN	NN	Number=Sing	_	_	_	_
5	death	death	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
6	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
7	inducing	induce	VERB	VBG	VerbForm=Ger	_	_	_	_
8	protein	protein	NOUN	NN	Number=Sing	_	_	_	_
9	shares	share	NOUN	NNS	Number=Plur	_	_	_	_
10	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
11	distinct	distinct	ADJ	JJ	Degree=Pos	_	_	_	_
12	sequence	sequence	NOUN	NN	Number=Sing	_	_	_	_
13	motif	motif	NOUN	NN	Number=Sing	_	_	_	_
14	with	with	ADP	IN	_	_	_	_	_
15	Bcl	Bcl	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
16	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
17	2	2	NUM	CD	NumType=Card	_	_	_	_
18	family	family	NOUN	NN	Number=Sing	_	_	_	_
19	proteins	protein	NOUN	NNS	Number=Plur	_	_	_	_
20	and	and	CCONJ	CC	_	_	_	_	_
21	interacts	interacts	NOUN	NNS	Number=Plur	_	_	_	_
22	with	with	ADP	IN	_	_	_	_	_
23	viral	viral	ADJ	JJ	Degree=Pos	_	_	_	_
24	and	and	CCONJ	CC	_	_	_	_	_
25	cellular	celular	ADJ	JJ	Degree=Pos	_	_	_	_
26	survival	survival	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
27	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
28	promoting	promoting	VERB	VBG	VerbForm=Ger	_	_	_	_
29	proteins	protein	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
30	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 2005
# text = The survival-promoting activity of the Bcl-2 family of proteins appears to be modulated by interactions between various cellular proteins.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	survival	survival	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
3	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
4	promoting	promote	VERB	VBG	VerbForm=Ger	_	_	_	_
5	activity	activity	NOUN	NN	Number=Sing	_	_	_	_
6	of	of	ADP	IN	_	_	_	_	_
7	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
8	Bcl	Bcl	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
9	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
10	2	2	NUM	CD	NumType=Card	_	_	_	_
11	family	family	NOUN	NN	Number=Sing	_	_	_	_
12	of	of	ADP	IN	_	_	_	_	_
13	proteins	protein	NOUN	NNS	Number=Plur	_	_	_	_
14	appears	appear	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
15	to	to	PART	TO	_	_	_	_	_
16	be	be	AUX	VB	VerbForm=Inf	_	_	_	_
17	modulated	modulate	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
18	by	by	ADP	IN	_	_	_	_	_
19	interactions	interaction	NOUN	NNS	Number=Plur	_	_	_	_
20	between	between	ADP	IN	_	_	_	_	_
21	various	various	ADJ	JJ	Degree=Pos	_	_	_	_
22	cellular	cellular	ADJ	JJ	Degree=Pos	_	_	_	_
23	proteins	protein	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
24	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2006
# text = We have identified a novel cellular protein, Bik, that interacts with the cellular survival-promoting proteins, Bcl-2 and Bcl-xL, as well as the viral survival-promoting proteins, Epstein Barr virus-BHRF1 and adenovirus E1B-19 kDa.
1	We	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
2	have	have	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
3	identified	identify	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
4	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
5	novel	novel	NOUN	NN	Number=Sing	_	_	_	_
6	cellular	celular	ADJ	JJ	Degree=Pos	_	_	_	_
7	protein	protein	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
8	,	,	PUNCT	,	_	_	_	_	_
9	Bik	Bik	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
10	,	,	PUNCT	,	_	_	_	_	_
11	that	that	PRON	WDT	PronType=Rel	_	_	_	_
12	interacts	interact	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
13	with	with	ADP	IN	_	_	_	_	_
14	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
15	cellular	cellular	ADJ	JJ	Degree=Pos	_	_	_	_
16	survival	survival	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
17	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
18	promoting	promoting	VERB	VBG	VerbForm=Ger	_	_	_	_
19	proteins	protein	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
20	,	,	PUNCT	,	_	_	_	_	_
21	Bcl	Bcl	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
22	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
23	2	2	NUM	CD	NumType=Card	_	_	_	_
24	and	and	CCONJ	CC	_	_	_	_	_
25	Bcl	Bcl	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
26	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
27	xL	xl	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
28	,	,	PUNCT	,	_	_	_	_	_
29	as	as	ADV	RB	_	_	_	_	_
30	well	well	ADV	RB	Degree=Pos	_	_	_	_
31	as	as	ADP	IN	_	_	_	_	_
32	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
33	viral	viral	ADJ	JJ	Degree=Pos	_	_	_	_
34	survival	survival	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
35	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
36	promoting	promoting	VERB	VBG	VerbForm=Ger	_	_	_	_
37	proteins	protein	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
38	,	,	PUNCT	,	_	_	_	_	_
39	Epstein	Epstein	PROPN	NNP	Number=Sing	_	_	_	_
40	Barr	Barr	PROPN	NNP	Number=Sing	_	_	_	_
41	virus	virus	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
42	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
43	BHRF1	Bhrf1	NOUN	NN	Number=Sing	_	_	_	_
44	and	and	CCONJ	CC	_	_	_	_	_
45	adenovirus	adenovirus	NOUN	NN	Number=Sing	_	_	_	_
46	E1B	E1b	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
47	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
48	19	19	NUM	CD	NumType=Card	_	_	_	_
49	kDa	kDa	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
50	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2007
# text = In transient transfection assays, Bik promotes cell death in a manner similar to the death-promoting members of the Bcl-2 family, Bax and Bak.
1	In	in	ADP	IN	_	_	_	_	_
2	transient	transient	ADJ	JJ	Degree=Pos	_	_	_	_
3	transfection	transfection	NOUN	NN	Number=Sing	_	_	_	_
4	assays	assay	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
5	,	,	PUNCT	,	_	_	_	_	_
6	Bik	Bik	PROPN	NNP	Number=Sing	_	_	_	_
7	promotes	promote	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
8	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
9	death	death	NOUN	NN	Number=Sing	_	_	_	_
10	in	in	ADP	IN	_	_	_	_	_
11	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
12	manner	manner	NOUN	NN	Number=Sing	_	_	_	_
13	similar	similar	ADJ	JJ	Degree=Pos	_	_	_	_
14	to	to	ADP	IN	_	_	_	_	_
15	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
16	death	death	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
17	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
18	promoting	promote	VERB	VBG	VerbForm=Ger	_	_	_	_
19	members	member	NOUN	NNS	Number=Plur	_	_	_	_
20	of	of	ADP	IN	_	_	_	_	_
21	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
22	Bcl	Bcl	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
23	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
24	2	2	NUM	CD	NumType=Card	_	_	_	_
25	family	family	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
26	,	,	PUNCT	,	_	_	_	_	_
27	Bax	Bax	PROPN	NNP	Number=Sing	_	_	_	_
28	and	and	CCONJ	CC	_	_	_	_	_
29	Bak	Bak	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
30	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2008
# text = This death-promoting activity of Bik can be suppressed by coexpression of Bcl-2, Bcl-XL, EBV-BHRF1 and E1B-19 kDa proteins suggesting that Bik may be a common target for both cellular and viral anti-apoptotic proteins.
1	This	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
2	death	death	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
3	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
4	promoting	promote	VERB	VBG	VerbForm=Ger	_	_	_	_
5	activity	activity	NOUN	NN	Number=Sing	_	_	_	_
6	of	of	ADP	IN	_	_	_	_	_
7	Bik	Bik	PROPN	NNP	Number=Sing	_	_	_	_
8	can	can	AUX	MD	VerbForm=Fin	_	_	_	_
9	be	be	AUX	VB	VerbForm=Inf	_	_	_	_
10	suppressed	suppress	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
11	by	by	ADP	IN	_	_	_	_	_
12	coexpression	coexpression	NOUN	NN	Number=Sing	_	_	_	_
13	of	of	ADP	IN	_	_	_	_	_
14	Bcl	Bcl	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
15	-2	-2	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
16	,	,	PUNCT	,	_	_	_	_	_
17	Bcl	Bcl	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
18	-XL	-XL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
19	,	,	PUNCT	,	_	_	_	_	_
20	EBV	EBV	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
21	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
22	BHRF1	BHRF1	PROPN	NNP	Number=Sing	_	_	_	_
23	and	and	CCONJ	CC	_	_	_	_	_
24	E1B	E1B	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
25	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
26	19	19	NUM	CD	NumType=Card	_	_	_	_
27	kDa	kDa	NOUN	NN	Number=Sing	_	_	_	_
28	proteins	protein	NOUN	NNS	Number=Plur	_	_	_	_
29	suggesting	suggest	VERB	VBG	VerbForm=Ger	_	_	_	_
30	that	that	SCONJ	IN	_	_	_	_	_
31	Bik	Bik	PROPN	NNP	Number=Sing	_	_	_	_
32	may	may	AUX	MD	VerbForm=Fin	_	_	_	_
33	be	be	AUX	VB	VerbForm=Inf	_	_	_	_
34	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
35	common	common	ADJ	JJ	Degree=Pos	_	_	_	_
36	target	target	NOUN	NN	Number=Sing	_	_	_	_
37	for	for	ADP	IN	_	_	_	_	_
38	both	both	CCONJ	CC	_	_	_	_	_
39	cellular	cellular	ADJ	JJ	Degree=Pos	_	_	_	_
40	and	and	CCONJ	CC	_	_	_	_	_
41	viral	viral	ADJ	JJ	Degree=Pos	_	_	_	_
42	anti-apoptotic	anti-apoptotic	ADJ	JJ	Degree=Pos	_	_	_	_
43	proteins	protein	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
44	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2009
# text = While Bik does not show overt homology to the BH1 and BH2 conserved domains characteristic of the Bcl-2 family, it does share a 9 amino acid domain (BH3) with Bax and Bak which may be a critical determinant for the death-promoting activity of these proteins.
1	While	while	SCONJ	IN	_	_	_	_	_
2	Bik	Bik	PROPN	NNP	Number=Sing	_	_	_	_
3	does	do	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
4	not	not	PART	RB	_	_	_	_	_
5	show	show	VERB	VB	VerbForm=Inf	_	_	_	_
6	overt	over	ADP	IN	Typo=Yes	_	_	_	_
7	homology	homology	NOUN	NN	Number=Sing	_	_	_	_
8	to	to	ADP	IN	_	_	_	_	_
9	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
10	BH1	Bh1	NOUN	NN	Number=Sing	_	_	_	_
11	and	and	CCONJ	CC	_	_	_	_	_
12	BH2	Bh2	NOUN	NN	Number=Sing	_	_	_	_
13	conserved	conserve	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
14	domains	domain	NOUN	NNS	Number=Plur	_	_	_	_
15	characteristic	characteristic	NOUN	NN	Number=Sing	_	_	_	_
16	of	of	ADP	IN	_	_	_	_	_
17	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
18	Bcl	Bcl	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
19	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
20	2	2	NUM	CD	NumType=Card	_	_	_	_
21	family	family	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
22	,	,	PUNCT	,	_	_	_	_	_
23	it	it	PRON	PRP	Case=Nom|Gender=Neut|Number=Sing|Person=3|PronType=Prs	_	_	_	_
24	does	do	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
25	share	share	VERB	VB	VerbForm=Inf	_	_	_	_
26	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
27	9	9	NUM	CD	NumType=Card	_	_	_	_
28	amino	amino	NOUN	NN	Number=Sing	_	_	_	_
29	acid	acid	NOUN	NN	Number=Sing	_	_	_	_
30	domain	domain	NOUN	NN	Number=Sing	_	_	_	_
31	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
32	BH3	BH3	X	LS	_	_	_	_	SpaceAfter=No
33	)	)	PUNCT	-RRB-	_	_	_	_	_
34	with	with	ADP	IN	_	_	_	_	_
35	Bax	Bax	PROPN	NNP	Number=Sing	_	_	_	_
36	and	and	CCONJ	CC	_	_	_	_	_
37	Bak	Bak	PROPN	NNP	Number=Sing	_	_	_	_
38	which	which	PRON	WDT	PronType=Rel	_	_	_	_
39	may	may	AUX	MD	VerbForm=Fin	_	_	_	_
40	be	be	AUX	VB	VerbForm=Inf	_	_	_	_
41	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
42	critical	critical	ADJ	JJ	Degree=Pos	_	_	_	_
43	determinant	determinant	NOUN	NN	Number=Sing	_	_	_	_
44	for	for	ADP	IN	_	_	_	_	_
45	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
46	death	death	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
47	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
48	promoting	promote	VERB	VBG	VerbForm=Ger	_	_	_	_
49	activity	activity	NOUN	NN	Number=Sing	_	_	_	_
50	of	of	ADP	IN	_	_	_	_	_
51	these	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
52	proteins	protein	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
53	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 2010
# text = Document 003003117 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	003003117	003003117	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 2011
# text = Cell type- and stage-specific expression of the CD20/B1 antigen correlates with the activity of a diverged octamer DNA motif present in its promoter.
1	Cell	cell	NOUN	NN	Number=Sing	_	_	_	_
2	type	type	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
3	-	-	PUNCT	,	_	_	_	_	_
4	and	and	CCONJ	CC	_	_	_	_	_
5	stage	stage	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
6	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
7	specific	specific	ADJ	JJ	Degree=Pos	_	_	_	_
8	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
9	of	of	ADP	IN	_	_	_	_	_
10	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
11	CD20/B1	CD20/B1	PROPN	NNP	Number=Sing	_	_	_	_
12	antigen	antigen	NOUN	NN	Number=Sing	_	_	_	_
13	correlates	correlate	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
14	with	with	ADP	IN	_	_	_	_	_
15	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
16	activity	activity	NOUN	NN	Number=Sing	_	_	_	_
17	of	of	ADP	IN	_	_	_	_	_
18	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
19	diverged	diverge	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
20	octamer	octamer	NOUN	NN	Number=Sing	_	_	_	_
21	DNA	dna	NOUN	NN	Number=Sing	_	_	_	_
22	motif	motif	NOUN	NN	Number=Sing	_	_	_	_
23	present	present	ADJ	JJ	Degree=Pos	_	_	_	_
24	in	in	ADP	IN	_	_	_	_	_
25	its	its	PRON	PRP$	Gender=Neut|Number=Sing|Person=3|Poss=Yes|PronType=Prs	_	_	_	_
26	promoter	promoter	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
27	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 2012
# text = The CD20(B1) gene encodes a B cell-specific protein involved in the regulation of human B cell proliferation and differentiation.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	CD20	CD20	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
3	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
4	B1	B1	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
5	)	)	PUNCT	-RRB-	_	_	_	_	_
6	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
7	encodes	encode	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
8	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
9	B	b	NOUN	NN	Number=Sing	_	_	_	_
10	cell	cell	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
11	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
12	specific	specific	ADJ	JJ	Degree=Pos	_	_	_	_
13	protein	protein	NOUN	NN	Number=Sing	_	_	_	_
14	involved	involve	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
15	in	in	ADP	IN	_	_	_	_	_
16	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
17	regulation	regulation	NOUN	NN	Number=Sing	_	_	_	_
18	of	of	ADP	IN	_	_	_	_	_
19	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
20	B	b	NOUN	NN	Number=Sing	_	_	_	_
21	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
22	proliferation	proliferation	NOUN	NN	Number=Sing	_	_	_	_
23	and	and	CCONJ	CC	_	_	_	_	_
24	differentiation	differentiation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
25	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2013
# text = Studies with 5' deletion CD20 promoter-CAT constructs have previously revealed two regions of the promoter between bases -186 and -280 and between bases -280 and -454 which contained positive regulatory elements.
1	Studies	study	NOUN	NNS	Number=Plur	_	_	_	_
2	with	with	ADP	IN	_	_	_	_	_
3	5	5	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
4	'	's	PUNCT	``	_	_	_	_	_
5	deletion	deletion	NOUN	NN	Number=Sing	_	_	_	_
6	CD20	CD20	NUM	CD	NumType=Card	_	_	_	_
7	promoter	promoter	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
8	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
9	CAT	Cat	NOUN	NN	Number=Sing	_	_	_	_
10	constructs	construct	NOUN	NNS	Number=Plur	_	_	_	_
11	have	have	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
12	previously	previously	ADV	RB	_	_	_	_	_
13	revealed	reveale	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
14	two	two	NUM	CD	NumType=Card	_	_	_	_
15	regions	region	NOUN	NNS	Number=Plur	_	_	_	_
16	of	of	ADP	IN	_	_	_	_	_
17	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
18	promoter	promoter	NOUN	NN	Number=Sing	_	_	_	_
19	between	between	ADP	IN	_	_	_	_	_
20	bases	bas	NOUN	NNS	Number=Plur	_	_	_	_
21	-186	-186	NUM	CD	NumType=Card	_	_	_	_
22	and	and	CCONJ	CC	_	_	_	_	_
23	-	-	SYM	SYM	_	_	_	_	SpaceAfter=No
24	280	280	NUM	CD	NumType=Card	_	_	_	_
25	and	and	CCONJ	CC	_	_	_	_	_
26	between	between	ADP	IN	_	_	_	_	_
27	bases	bas	NOUN	NNS	Number=Plur	_	_	_	_
28	-280	-280	NUM	CD	NumType=Card	_	_	_	_
29	and	and	CCONJ	CC	_	_	_	_	_
30	-	-	SYM	SYM	_	_	_	_	SpaceAfter=No
31	454	454	NUM	CD	NumType=Card	_	_	_	_
32	which	which	PRON	WDT	PronType=Rel	_	_	_	_
33	contained	contain	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
34	positive	positive	ADJ	JJ	Degree=Pos	_	_	_	_
35	regulatory	regulatory	ADJ	JJ	Degree=Pos	_	_	_	_
36	elements	element	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
37	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2014
# text = In this study we identified a sequence element present in the most proximal region located between bases -214 and -201, TTCTTCTAATTAA, which is important in the high constitutive expression of CD20 in mature B cells and the induction of CD20 in pre-B cells.
1	In	in	ADP	IN	_	_	_	_	_
2	this	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
3	study	study	NOUN	NN	Number=Sing	_	_	_	_
4	we	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
5	identified	identify	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
6	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
7	sequence	sequence	NOUN	NN	Number=Sing	_	_	_	_
8	element	element	NOUN	NN	Number=Sing	_	_	_	_
9	present	present	VERB	VB	VerbForm=Inf	_	_	_	_
10	in	in	ADP	IN	_	_	_	_	_
11	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
12	most	most	ADV	RBS	_	_	_	_	_
13	proximal	proximal	ADJ	JJ	Degree=Pos	_	_	_	_
14	region	region	NOUN	NN	Number=Sing	_	_	_	_
15	located	locate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
16	between	between	ADP	IN	_	_	_	_	_
17	bases	bas	NOUN	NNS	Number=Plur	_	_	_	_
18	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
19	214	214	NUM	CD	NumType=Card	_	_	_	_
20	and	and	CCONJ	CC	_	_	_	_	_
21	-	-	SYM	SYM	_	_	_	_	SpaceAfter=No
22	201	201	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
23	,	,	PUNCT	,	_	_	_	_	_
24	TTCTTCTAATTAA	TTCTTCTAATTAa	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
25	,	,	PUNCT	,	_	_	_	_	_
26	which	which	PRON	WDT	PronType=Rel	_	_	_	_
27	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
28	important	important	ADJ	JJ	Degree=Pos	_	_	_	_
29	in	in	ADP	IN	_	_	_	_	_
30	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
31	high	high	ADJ	JJ	Degree=Pos	_	_	_	_
32	constitutive	constitutive	ADJ	JJ	Degree=Pos	_	_	_	_
33	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
34	of	of	ADP	IN	_	_	_	_	_
35	CD20	CD20	PROPN	NNP	Number=Sing	_	_	_	_
36	in	in	ADP	IN	_	_	_	_	_
37	mature	mature	ADJ	JJ	Degree=Pos	_	_	_	_
38	B	b	ADJ	JJ	Degree=Pos	_	_	_	_
39	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
40	and	and	CCONJ	CC	_	_	_	_	_
41	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
42	induction	induction	NOUN	NN	Number=Sing	_	_	_	_
43	of	of	ADP	IN	_	_	_	_	_
44	CD20	CD20	PROPN	NNP	Number=Sing	_	_	_	_
45	in	in	ADP	IN	_	_	_	_	_
46	pre	pre	X	AFX	_	_	_	_	SpaceAfter=No
47	-B	-b	ADJ	JJ	Degree=Pos	_	_	_	_
48	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
49	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2015
# text = This sequence element was referred to as the BAT box and its deletion significantly reduced the activity of a CD20 promoter-CAT construct in B cells.
1	This	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
2	sequence	sequence	NOUN	NN	Number=Sing	_	_	_	_
3	element	element	NOUN	NN	Number=Sing	_	_	_	_
4	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
5	referred	refer	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
6	to	to	ADP	IN	_	_	_	_	_
7	as	as	ADP	IN	_	_	_	_	_
8	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
9	BAT	bat	NOUN	NN	Number=Sing	_	_	_	_
10	box	box	NOUN	NN	Number=Sing	_	_	_	_
11	and	and	CCONJ	CC	_	_	_	_	_
12	its	its	PRON	PRP$	Gender=Neut|Number=Sing|Person=3|Poss=Yes|PronType=Prs	_	_	_	_
13	deletion	deletion	NOUN	NN	Number=Sing	_	_	_	_
14	significantly	significantly	ADV	RB	_	_	_	_	_
15	reduced	reduce	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
16	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
17	activity	activity	NOUN	NN	Number=Sing	_	_	_	_
18	of	of	ADP	IN	_	_	_	_	_
19	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
20	CD20	CD20	PROPN	NNP	Number=Sing	_	_	_	_
21	promoter	promoter	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
22	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
23	CAT	cat	NOUN	NN	Number=Sing	_	_	_	_
24	construct	construct	NOUN	NN	Number=Sing	_	_	_	_
25	in	in	ADP	IN	_	_	_	_	_
26	B	b	ADJ	JJ	Degree=Pos	_	_	_	_
27	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
28	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2016
# text = Mobility shift assays with various mutant probes and B cell nuclear extracts demonstrated that the core sequence TAAT was essential for binding to this site.
1	Mobility	Mobility	NOUN	NN	Number=Sing	_	_	_	_
2	shift	shift	NOUN	NN	Number=Sing	_	_	_	_
3	assays	assay	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
4	with	with	ADP	IN	_	_	_	_	_
5	various	various	ADJ	JJ	Degree=Pos	_	_	_	_
6	mutant	mutant	ADJ	JJ	Degree=Pos	_	_	_	_
7	probes	probe	NOUN	NNS	Number=Plur	_	_	_	_
8	and	and	CCONJ	CC	_	_	_	_	_
9	B	b	ADJ	JJ	Degree=Pos	_	_	_	_
10	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
11	nuclear	nuclear	ADJ	JJ	Degree=Pos	_	_	_	_
12	extracts	extract	NOUN	NNS	Number=Plur	_	_	_	_
13	demonstrated	demonstrate	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
14	that	that	SCONJ	IN	_	_	_	_	_
15	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
16	core	core	NOUN	NN	Number=Sing	_	_	_	_
17	sequence	sequence	NOUN	NN	Number=Sing	_	_	_	_
18	TAAT	Taat	PRON	WDT	PronType=Rel	_	_	_	_
19	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
20	essential	essential	ADJ	JJ	Degree=Pos	_	_	_	_
21	for	for	SCONJ	IN	_	_	_	_	_
22	binding	bind	VERB	VBG	VerbForm=Ger	_	_	_	_
23	to	to	ADP	IN	_	_	_	_	_
24	this	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
25	site	site	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
26	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2017
# text = Cross competition experiments with an octamer sequence from the Ig heavy chain promoter, the BAT box, and a TA-rich sequence present in the CD21 promoter revealed that all three sequences bound the same nuclear proteins suggesting that the BAT box binding proteins were Oct-1 and Oct-2. Southwestern blotting and UV cross-linking studies confirmed that the BAT box binding proteins were Oct-1 and Oct-2.
1	Cross	cross	VERB	VB	Mood=Imp|VerbForm=Fin	_	_	_	_
2	competition	competition	NOUN	NN	Number=Sing	_	_	_	_
3	experiments	experiment	NOUN	NNS	Number=Plur	_	_	_	_
4	with	with	ADP	IN	_	_	_	_	_
5	an	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
6	octamer	octamer	ADJ	JJ	Degree=Pos	_	_	_	_
7	sequence	sequence	NOUN	NN	Number=Sing	_	_	_	_
8	from	from	ADP	IN	_	_	_	_	_
9	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
10	Ig	ig	PROPN	NNP	Number=Sing	_	_	_	_
11	heavy	heavy	ADJ	JJ	Degree=Pos	_	_	_	_
12	chain	chain	NOUN	NN	Number=Sing	_	_	_	_
13	promoter	promoter	ADV	RBR	Degree=Cmp	_	_	_	SpaceAfter=No
14	,	,	PUNCT	,	_	_	_	_	_
15	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
16	BAT	bat	NOUN	NN	Number=Sing	_	_	_	_
17	box	box	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
18	,	,	PUNCT	,	_	_	_	_	_
19	and	and	CCONJ	CC	_	_	_	_	_
20	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
21	TA	Ta	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
22	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
23	rich	rich	ADJ	JJ	Degree=Pos	_	_	_	_
24	sequence	sequence	NOUN	NN	Number=Sing	_	_	_	_
25	present	present	ADJ	JJ	Degree=Pos	_	_	_	_
26	in	in	ADP	IN	_	_	_	_	_
27	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
28	CD21	Cd21	PROPN	NNP	Number=Sing	_	_	_	_
29	promoter	promoter	NOUN	NN	Number=Sing	_	_	_	_
30	revealed	reveal	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
31	that	that	SCONJ	IN	_	_	_	_	_
32	all	all	DET	DT	_	_	_	_	_
33	three	three	NUM	CD	NumType=Card	_	_	_	_
34	sequences	sequence	NOUN	NNS	Number=Plur	_	_	_	_
35	bound	bound	ADP	IN	_	_	_	_	_
36	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
37	same	same	ADJ	JJ	Degree=Pos	_	_	_	_
38	nuclear	nuclear	ADJ	JJ	Degree=Pos	_	_	_	_
39	proteins	protein	NOUN	NNS	Number=Plur	_	_	_	_
40	suggesting	suggest	VERB	VBG	VerbForm=Ger	_	_	_	_
41	that	that	SCONJ	IN	_	_	_	_	_
42	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
43	BAT	bat	NOUN	NN	Number=Sing	_	_	_	_
44	box	box	NOUN	NN	Number=Sing	_	_	_	_
45	binding	bind	VERB	VBG	VerbForm=Ger	_	_	_	_
46	proteins	protein	NOUN	NNS	Number=Plur	_	_	_	_
47	were	be	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
48	Oct	Oct	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
49	-1	-1	NUM	CD	NumType=Card	_	_	_	_
50	and	and	CCONJ	CC	_	_	_	_	_
51	Oct	Oct	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
52	-2	-2	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
53	.	.	PUNCT	.	_	_	_	_	_
54	Southwestern	southwestern	ADJ	JJ	Degree=Pos	_	_	_	_
55	blotting	blotting	NOUN	NN	Number=Sing	_	_	_	_
56	and	and	CCONJ	CC	_	_	_	_	_
57	UV	UV	PROPN	NNP	Number=Sing	_	_	_	_
58	cross	cross	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
59	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
60	linking	link	NOUN	NN	Number=Sing	_	_	_	_
61	studies	study	NOUN	NNS	Number=Plur	_	_	_	_
62	confirmed	confirm	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
63	that	that	SCONJ	IN	_	_	_	_	_
64	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
65	BAT	bat	NOUN	NN	Number=Sing	_	_	_	_
66	box	box	NOUN	NN	Number=Sing	_	_	_	_
67	binding	bind	VERB	VBG	VerbForm=Ger	_	_	_	_
68	proteins	protein	NOUN	NNS	Number=Plur	_	_	_	_
69	were	be	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
70	Oct	Oct	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
71	-1	-1	NUM	CD	NumType=Card	_	_	_	_
72	and	and	CCONJ	CC	_	_	_	_	_
73	Oct	Oct	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
74	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
75	2	2	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
76	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2018
# text = The affinity of the BAT box binding proteins for the BAT box was approximately 25-fold less than for the octamer sequence and the BAT box binding proteins dissociated from the BAT box 10-fold more rapidly than from the octamer sequence.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	affinity	affinity	NOUN	NN	Number=Sing	_	_	_	_
3	of	of	ADP	IN	_	_	_	_	_
4	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
5	BAT	bat	NOUN	NN	Number=Sing	_	_	_	_
6	box	box	NOUN	NN	Number=Sing	_	_	_	_
7	binding	bind	VERB	VBG	VerbForm=Ger	_	_	_	_
8	proteins	protein	NOUN	NNS	Number=Plur	_	_	_	_
9	for	for	ADP	IN	_	_	_	_	_
10	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
11	BAT	bat	NOUN	NN	Number=Sing	_	_	_	_
12	box	box	NOUN	NN	Number=Sing	_	_	_	_
13	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
14	approximately	approximately	ADV	RB	_	_	_	_	_
15	25	25	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
16	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
17	fold	fold	NOUN	NN	Number=Sing	_	_	_	_
18	less	less	ADJ	JJR	Degree=Cmp	_	_	_	_
19	than	than	ADP	IN	_	_	_	_	_
20	for	for	ADP	IN	_	_	_	_	_
21	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
22	octamer	octamer	NOUN	NN	Number=Sing	_	_	_	_
23	sequence	sequence	NOUN	NN	Number=Sing	_	_	_	_
24	and	and	CCONJ	CC	_	_	_	_	_
25	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
26	BAT	bat	NOUN	NN	Number=Sing	_	_	_	_
27	box	box	NOUN	NN	Number=Sing	_	_	_	_
28	binding	bind	VERB	VBG	VerbForm=Ger	_	_	_	_
29	proteins	protein	NOUN	NNS	Number=Plur	_	_	_	_
30	dissociated	dissociate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
31	from	from	ADP	IN	_	_	_	_	_
32	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
33	BAT	bat	PROPN	NNP	Number=Sing	_	_	_	_
34	box	box	NOUN	NN	Number=Sing	_	_	_	_
35	10	10	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
36	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
37	fold	fold	VERB	VB	VerbForm=Inf	_	_	_	_
38	more	more	ADV	RBR	_	_	_	_	_
39	rapidly	rapidly	ADV	RB	_	_	_	_	_
40	than	than	ADP	IN	_	_	_	_	_
41	from	from	ADP	IN	_	_	_	_	_
42	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
43	octamer	octamer	NOUN	NN	Number=Sing	_	_	_	_
44	sequence	sequence	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
45	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2019
# text = Despite this lower affinity, a trimer of the BAT box sequence was as efficiently transactivated by an Oct-2 expression vector as was a trimer of the octamer sequence in HeLa cells.
1	Despite	despite	ADP	IN	_	_	_	_	_
2	this	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
3	lower	lower	ADJ	JJR	Degree=Cmp	_	_	_	_
4	affinity	affinity	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
5	,	,	PUNCT	,	_	_	_	_	_
6	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
7	trimer	trimer	NOUN	NN	Number=Sing	_	_	_	_
8	of	of	ADP	IN	_	_	_	_	_
9	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
10	BAT	bat	PROPN	NNP	Number=Sing	_	_	_	_
11	box	box	NOUN	NN	Number=Sing	_	_	_	_
12	sequence	sequence	NOUN	NN	Number=Sing	_	_	_	_
13	was	be	VERB	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
14	as	as	SCONJ	IN	_	_	_	_	_
15	efficiently	efficiently	ADV	RB	_	_	_	_	_
16	transactivated	transactivate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
17	by	by	ADP	IN	_	_	_	_	_
18	an	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
19	Oct	Oct	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
20	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
21	2	2	NUM	CD	NumType=Card	_	_	_	_
22	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
23	vector	vector	NOUN	NN	Number=Sing	_	_	_	_
24	as	as	SCONJ	IN	_	_	_	_	_
25	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
26	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
27	trimer	trimer	NOUN	NN	Number=Sing	_	_	_	_
28	of	of	ADP	IN	_	_	_	_	_
29	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
30	octamer	octamer	ADJ	JJ	Degree=Pos	_	_	_	_
31	sequence	sequence	NOUN	NN	Number=Sing	_	_	_	_
32	in	in	ADP	IN	_	_	_	_	_
33	HeLa	HeLa	PROPN	NNP	Number=Sing	_	_	_	_
34	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
35	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2020
# text = The BAT box and Oct-2 were also implicated in the induction of CD20 in the pre-B cell line, PB-697, via phorbol esters.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	BAT	bat	NOUN	NN	Number=Sing	_	_	_	_
3	box	box	NOUN	NN	Number=Sing	_	_	_	_
4	and	and	CCONJ	CC	_	_	_	_	_
5	Oct	Oct	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
6	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
7	2	2	NUM	CD	NumType=Card	_	_	_	_
8	were	be	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
9	also	also	ADV	RB	_	_	_	_	_
10	implicated	implicate	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
11	in	in	ADP	IN	_	_	_	_	_
12	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
13	induction	induction	NOUN	NN	Number=Sing	_	_	_	_
14	of	of	ADP	IN	_	_	_	_	_
15	CD20	CD20	NUM	CD	NumType=Card	_	_	_	_
16	in	in	ADP	IN	_	_	_	_	_
17	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
18	pre	pre	X	AFX	_	_	_	_	SpaceAfter=No
19	-B	-b	ADJ	JJ	Degree=Pos	_	_	_	_
20	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
21	line	line	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
22	,	,	PUNCT	,	_	_	_	_	_
23	PB	Pb	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
24	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
25	697	697	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
26	,	,	PUNCT	,	_	_	_	_	_
27	via	via	ADP	IN	_	_	_	_	_
28	phorbol	phorbol	ADJ	JJ	Degree=Pos	_	_	_	_
29	esters	ester	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
30	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2021
# text = The induction of CD20 mRNA was temporally associated with induction of Oct-2 mRNA and a BAT box-deleted CD20-CAT construct, in contrast to the wild type, was poorly induced by phorbol esters.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	induction	induction	NOUN	NN	Number=Sing	_	_	_	_
3	of	of	ADP	IN	_	_	_	_	_
4	CD20	CD20	PROPN	NNP	Number=Sing	_	_	_	_
5	mRNA	mRNA	PROPN	NNP	Number=Sing	_	_	_	_
6	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
7	temporally	temporally	ADV	RB	_	_	_	_	_
8	associated	associate	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
9	with	with	ADP	IN	_	_	_	_	_
10	induction	induction	NOUN	NN	Number=Sing	_	_	_	_
11	of	of	ADP	IN	_	_	_	_	_
12	Oct	Oct	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
13	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
14	2	2	NUM	CD	NumType=Card	_	_	_	_
15	mRNA	mRNa	NOUN	NN	Number=Sing	_	_	_	_
16	and	and	CCONJ	CC	_	_	_	_	_
17	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
18	BAT	bat	NOUN	NN	Number=Sing	_	_	_	_
19	box	box	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
20	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
21	deleted	delet	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
22	CD20	CD20	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
23	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
24	CAT	cat	PROPN	NNP	Number=Sing	_	_	_	_
25	construct	construct	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
26	,	,	PUNCT	,	_	_	_	_	_
27	in	in	ADP	IN	_	_	_	_	_
28	contrast	contrast	NOUN	NN	Number=Sing	_	_	_	_
29	to	to	ADP	IN	_	_	_	_	_
30	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
31	wild	wild	NOUN	NN	Number=Sing	_	_	_	_
32	type	type	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
33	,	,	PUNCT	,	_	_	_	_	_
34	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
35	poorly	poorly	ADV	RB	_	_	_	_	_
36	induced	induce	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
37	by	by	ADP	IN	_	_	_	_	_
38	phorbol	phorbol	NOUN	NN	Number=Sing	_	_	_	_
39	esters	ester	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
40	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2022
# text = Together these results suggest that the BAT box binding proteins are important in the B cell specific expression of CD20 and perhaps CD21.
1	Together	together	SCONJ	IN	_	_	_	_	_
2	these	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
3	results	result	NOUN	NNS	Number=Plur	_	_	_	_
4	suggest	suggest	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
5	that	that	SCONJ	IN	_	_	_	_	_
6	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
7	BAT	bat	NOUN	NN	Number=Sing	_	_	_	_
8	box	box	NOUN	NN	Number=Sing	_	_	_	_
9	binding	binding	VERB	VBG	VerbForm=Ger	_	_	_	_
10	proteins	protein	NOUN	NNS	Number=Plur	_	_	_	_
11	are	be	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
12	important	important	ADJ	JJ	Degree=Pos	_	_	_	_
13	in	in	ADP	IN	_	_	_	_	_
14	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
15	B	b	PROPN	NNP	Number=Sing	_	_	_	_
16	cell	cell	PROPN	NNP	Number=Sing	_	_	_	_
17	specific	specific	ADJ	JJ	Degree=Pos	_	_	_	_
18	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
19	of	of	ADP	IN	_	_	_	_	_
20	CD20	CD20	PROPN	NNP	Number=Sing	_	_	_	_
21	and	and	CCONJ	CC	_	_	_	_	_
22	perhaps	perhaps	ADV	RB	_	_	_	_	_
23	CD21	Cd21	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
24	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 2023
# text = Document 003003118 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	003003118	003003118	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 2024
# text = Retinoic acid-induced expression of CD38 antigen in myeloid cells is mediated through retinoic acid receptor-alpha.
1	Retinoic	Retinoic	ADJ	JJ	Degree=Pos	_	_	_	_
2	acid	acid	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
3	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
4	induced	induce	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
5	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
6	of	of	ADP	IN	_	_	_	_	_
7	CD38	CD38	PROPN	NNP	Number=Sing	_	_	_	_
8	antigen	antigen	NOUN	NNS	Number=Plur	_	_	_	_
9	in	in	ADP	IN	_	_	_	_	_
10	myeloid	myeloid	ADJ	JJ	Degree=Pos	_	_	_	_
11	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
12	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
13	mediated	mediate	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
14	through	through	ADP	IN	_	_	_	_	_
15	retinoic	retinoic	ADJ	JJ	Degree=Pos	_	_	_	_
16	acid	acid	ADJ	JJ	Degree=Pos	_	_	_	_
17	receptor	receptor	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
18	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
19	alpha	alpha	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
20	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 2025
# text = CD38 is a leukocyte differentiation antigen that has been thought to be a phenotypic marker of different subpopulations of T- and B- lymphocytes.
1	CD38	Cd38	NOUN	NN	Number=Sing	_	_	_	_
2	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
3	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
4	leukocyte	leukocyte	NOUN	NN	Number=Sing	_	_	_	_
5	differentiation	differentiation	NOUN	NN	Number=Sing	_	_	_	_
6	antigen	antigen	NOUN	NN	Number=Sing	_	_	_	_
7	that	that	PRON	WDT	PronType=Rel	_	_	_	_
8	has	have	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
9	been	be	AUX	VBN	Tense=Past|VerbForm=Part	_	_	_	_
10	thought	think	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
11	to	to	PART	TO	_	_	_	_	_
12	be	be	AUX	VB	VerbForm=Inf	_	_	_	_
13	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
14	phenotypic	phenotypic	ADJ	JJ	Degree=Pos	_	_	_	_
15	marker	marker	NOUN	NN	Number=Sing	_	_	_	_
16	of	of	ADP	IN	_	_	_	_	_
17	different	different	ADJ	JJ	Degree=Pos	_	_	_	_
18	subpopulations	subpopulation	NOUN	NNS	Number=Plur	_	_	_	_
19	of	of	ADP	IN	_	_	_	_	_
20	T	t	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
21	-	-	PUNCT	,	_	_	_	_	_
22	and	and	CCONJ	CC	_	_	_	_	_
23	B	b	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
24	-	-	PUNCT	HYPH	_	_	_	_	_
25	lymphocytes	lymphocyte	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
26	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2026
# text = In myeloid cells, CD38 is expressed during early stages of differentiation.
1	In	in	ADP	IN	_	_	_	_	_
2	myeloid	myeloid	ADJ	JJ	Degree=Pos	_	_	_	_
3	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	,	,	PUNCT	,	_	_	_	_	_
5	CD38	CD38	PROPN	NNP	Number=Sing	_	_	_	_
6	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
7	expressed	express	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
8	during	during	ADP	IN	_	_	_	_	_
9	early	early	ADJ	JJ	Degree=Pos	_	_	_	_
10	stages	stage	NOUN	NNS	Number=Plur	_	_	_	_
11	of	of	ADP	IN	_	_	_	_	_
12	differentiation	differentiation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
13	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2027
# text = Virtually no information is available on regulation and functions of CD38.
1	Virtually	virtually	ADV	RB	_	_	_	_	_
2	no	no	DET	DT	_	_	_	_	_
3	information	information	NOUN	NN	Number=Sing	_	_	_	_
4	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
5	available	available	ADJ	JJ	Degree=Pos	_	_	_	_
6	on	on	ADP	IN	_	_	_	_	_
7	regulation	regulation	NOUN	NN	Number=Sing	_	_	_	_
8	and	and	CCONJ	CC	_	_	_	_	_
9	functions	function	NOUN	NNS	Number=Plur	_	_	_	_
10	of	of	ADP	IN	_	_	_	_	_
11	CD	CD	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
12	38	38	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
13	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2028
# text = Recently we reported that all-trans-retinoic acid (ATRA) is a potent and highly specific inducer of CD38 expression in human promyelocytic leukemia cells.
1	Recently	recently	ADV	RB	_	_	_	_	_
2	we	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
3	reported	report	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
4	that	that	SCONJ	IN	_	_	_	_	_
5	all	all	DET	DT	_	_	_	_	SpaceAfter=No
6	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
7	trans	tran	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
8	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
9	retinoic	retinoic	ADJ	JJ	Degree=Pos	_	_	_	_
10	acid	acid	NOUN	NN	Number=Sing	_	_	_	_
11	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
12	ATRA	ATRA	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
13	)	)	PUNCT	-RRB-	_	_	_	_	_
14	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
15	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
16	potent	potent	NOUN	NN	Number=Sing	_	_	_	_
17	and	and	CCONJ	CC	_	_	_	_	_
18	highly	highly	ADV	RB	_	_	_	_	_
19	specific	specific	ADJ	JJ	Degree=Pos	_	_	_	_
20	inducer	inducer	NOUN	NN	Number=Sing	_	_	_	_
21	of	of	ADP	IN	_	_	_	_	_
22	CD38	CD38	NUM	CD	NumType=Card	_	_	_	_
23	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
24	in	in	ADP	IN	_	_	_	_	_
25	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
26	promyelocytic	promyelocytic	ADJ	JJ	Degree=Pos	_	_	_	_
27	leukemia	leukemia	NOUN	NN	Number=Sing	_	_	_	_
28	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
29	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2029
# text = Here we report that ATRA-induced expression of CD38 antigen in myeloid cells is mediated through retinoic acid-alpha receptor (RAR alpha).
1	Here	here	ADV	RB	PronType=Dem	_	_	_	_
2	we	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
3	report	report	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
4	that	that	SCONJ	IN	_	_	_	_	_
5	ATRA	ATRA	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
6	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
7	induced	induce	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
8	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
9	of	of	ADP	IN	_	_	_	_	_
10	CD38	CD38	PROPN	NNP	Number=Sing	_	_	_	_
11	antigen	antigen	NOUN	NNS	Number=Plur	_	_	_	_
12	in	in	ADP	IN	_	_	_	_	_
13	myeloid	myeloid	ADJ	JJ	Degree=Pos	_	_	_	_
14	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
15	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
16	mediated	mediate	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
17	through	through	ADP	IN	_	_	_	_	_
18	retinoic	retinoic	ADJ	JJ	Degree=Pos	_	_	_	_
19	acid	acid	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
20	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
21	alpha	alpha	NOUN	NN	Number=Sing	_	_	_	_
22	receptor	receptor	NOUN	NN	Number=Sing	_	_	_	_
23	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
24	RAR	Rar	NOUN	NN	Number=Sing	_	_	_	_
25	alpha	alpha	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
26	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
27	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2030
# text = ATRA failed to induce CD38 expression in a mutant subclone of the HL-60 myeloid leukemia cell line (designated HL-60R) that is relatively resistant to ATRA-induced granulocytic differentiation.
1	ATRA	ATRA	PROPN	NNP	Number=Sing	_	_	_	_
2	failed	fail	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
3	to	to	PART	TO	_	_	_	_	_
4	induce	induce	VERB	VB	VerbForm=Inf	_	_	_	_
5	CD38	Cd38	NUM	CD	NumType=Card	_	_	_	_
6	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
7	in	in	ADP	IN	_	_	_	_	_
8	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
9	mutant	mutant	ADJ	JJ	Degree=Pos	_	_	_	_
10	subclone	subclone	NOUN	NN	Number=Sing	_	_	_	_
11	of	of	ADP	IN	_	_	_	_	_
12	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
13	HL	HL	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
14	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
15	60	60	NUM	CD	NumType=Card	_	_	_	_
16	myeloid	myeloid	NOUN	NN	Number=Sing	_	_	_	_
17	leukemia	leukemia	NOUN	NN	Number=Sing	_	_	_	_
18	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
19	line	line	NOUN	NN	Number=Sing	_	_	_	_
20	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
21	designated	designate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
22	HL	HL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
23	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
24	60R	60R	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
25	)	)	PUNCT	-RRB-	_	_	_	_	_
26	that	that	PRON	WDT	PronType=Rel	_	_	_	_
27	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
28	relatively	relatively	ADV	RB	_	_	_	_	_
29	resistant	resistant	ADJ	JJ	Degree=Pos	_	_	_	_
30	to	to	ADP	IN	_	_	_	_	_
31	ATRA	ATRA	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
32	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
33	induced	induce	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
34	granulocytic	granulocytic	ADJ	JJ	Degree=Pos	_	_	_	_
35	differentiation	differentiation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
36	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2031
# text = Retroviral vector-mediated transduction of RA receptor (RAR alpha) into this HL-60R subclone completely restored the sensitivity of these cells to ATRA in terms of their ability to express CD38.
1	Retroviral	Retroviral	ADJ	JJ	Degree=Pos	_	_	_	_
2	vector	vector	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
3	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
4	mediated	mediate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
5	transduction	transduction	NOUN	NN	Number=Sing	_	_	_	_
6	of	of	ADP	IN	_	_	_	_	_
7	RA	RA	PROPN	NNP	Number=Sing	_	_	_	_
8	receptor	receptor	NOUN	NN	Number=Sing	_	_	_	_
9	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
10	RAR	Rar	NOUN	NN	Number=Sing	_	_	_	_
11	alpha	alpha	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
12	)	)	PUNCT	-RRB-	_	_	_	_	_
13	into	into	ADP	IN	_	_	_	_	_
14	this	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
15	HL	Hl	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
16	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
17	60R	60r	NOUN	NN	Number=Sing	_	_	_	_
18	subclone	subclone	NOUN	NN	Number=Sing	_	_	_	_
19	completely	completely	ADV	RB	_	_	_	_	_
20	restored	restore	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
21	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
22	sensitivity	sensitivity	NOUN	NN	Number=Sing	_	_	_	_
23	of	of	ADP	IN	_	_	_	_	_
24	these	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
25	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
26	to	to	ADP	IN	_	_	_	_	_
27	ATRA	ATRA	PROPN	NNP	Number=Sing	_	_	_	_
28	in	in	ADP	IN	_	_	_	_	_
29	terms	term	NOUN	NNS	Number=Plur	_	_	_	_
30	of	of	ADP	IN	_	_	_	_	_
31	their	they	PRON	PRP$	Number=Plur|Person=3|Poss=Yes|PronType=Prs	_	_	_	_
32	ability	ability	NOUN	NN	Number=Sing	_	_	_	_
33	to	to	PART	TO	_	_	_	_	_
34	express	express	VERB	VB	VerbForm=Inf	_	_	_	_
35	CD38	CD38	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
36	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2032
# text = In contrast, CD38 expression was not inducible by ATRA in HL-60R cells, transfected with a functional RAR beta, RAR gamma, or RXR alpha receptor.
1	In	in	ADP	IN	_	_	_	_	_
2	contrast	contrast	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
3	,	,	PUNCT	,	_	_	_	_	_
4	CD38	CD38	NUM	CD	NumType=Card	_	_	_	_
5	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
6	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
7	not	not	PART	RB	_	_	_	_	_
8	inducible	inducible	ADJ	JJ	Degree=Pos	_	_	_	_
9	by	by	ADP	IN	_	_	_	_	_
10	ATRA	ATRA	PROPN	NNP	Number=Sing	_	_	_	_
11	in	in	ADP	IN	_	_	_	_	_
12	HL	HL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
13	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
14	60R	60r	PROPN	NNP	Number=Sing	_	_	_	_
15	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
16	,	,	PUNCT	,	_	_	_	_	_
17	transfected	transfect	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
18	with	with	ADP	IN	_	_	_	_	_
19	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
20	functional	functional	ADJ	JJ	Degree=Pos	_	_	_	_
21	RAR	RAR	PROPN	NNP	Number=Sing	_	_	_	_
22	beta	beta	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
23	,	,	PUNCT	,	_	_	_	_	_
24	RAR	RAR	PROPN	NNP	Number=Sing	_	_	_	_
25	gamma	gamma	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
26	,	,	PUNCT	,	_	_	_	_	_
27	or	or	CCONJ	CC	_	_	_	_	_
28	RXR	RXR	PROPN	NNP	Number=Sing	_	_	_	_
29	alpha	alpha	PROPN	NNP	Number=Sing	_	_	_	_
30	receptor	receptor	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
31	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2033
# text = Induction of CD38 in acute promyelocytic and acute myeloblastic leukemia cells was independent of ATRA-induced cytodifferentiation.
1	Induction	Induction	NOUN	NN	Number=Sing	_	_	_	_
2	of	of	ADP	IN	_	_	_	_	_
3	CD38	CD38	PROPN	NNP	Number=Sing	_	_	_	_
4	in	in	ADP	IN	_	_	_	_	_
5	acute	acute	ADJ	JJ	Degree=Pos	_	_	_	_
6	promyelocytic	promyelocytic	ADJ	JJ	Degree=Pos	_	_	_	_
7	and	and	CCONJ	CC	_	_	_	_	_
8	acute	acute	ADJ	JJ	Degree=Pos	_	_	_	_
9	myeloblastic	myeloblastic	ADJ	JJ	Degree=Pos	_	_	_	_
10	leukemia	leukemia	NOUN	NN	Number=Sing	_	_	_	_
11	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
12	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
13	independent	independent	ADJ	JJ	Degree=Pos	_	_	_	_
14	of	of	ADP	IN	_	_	_	_	_
15	ATRA	ATRA	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
16	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
17	induced	induce	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
18	cytodifferentiation	cytodifferentiation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
19	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2034
# text = Following culture with ATRA, increased CD38 protein levels were also observed in normal CD34+ bone marrow cells, but not on normal circulating granulocytes.
1	Following	follow	VERB	VBG	VerbForm=Ger	_	_	_	_
2	culture	culture	NOUN	NN	Number=Sing	_	_	_	_
3	with	with	ADP	IN	_	_	_	_	_
4	ATRA	ATRA	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
5	,	,	PUNCT	,	_	_	_	_	_
6	increased	increase	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
7	CD38	CD38	NUM	CD	NumType=Card	_	_	_	_
8	protein	protein	NOUN	NN	Number=Sing	_	_	_	_
9	levels	level	NOUN	NNS	Number=Plur	_	_	_	_
10	were	be	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
11	also	also	ADV	RB	_	_	_	_	_
12	observed	observe	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
13	in	in	ADP	IN	_	_	_	_	_
14	normal	normal	ADJ	JJ	Degree=Pos	_	_	_	_
15	CD34	CD34	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
16	+	+	SYM	SYM	_	_	_	_	_
17	bone	bone	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
18	marrow	marrow	ADJ	JJ	Degree=Pos	_	_	_	_
19	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
20	,	,	PUNCT	,	_	_	_	_	_
21	but	but	CCONJ	CC	_	_	_	_	_
22	not	not	ADV	RB	_	_	_	_	_
23	on	on	ADP	IN	_	_	_	_	_
24	normal	normal	ADJ	JJ	Degree=Pos	_	_	_	_
25	circulating	circulating	NOUN	NN	Number=Sing	_	_	_	_
26	granulocytes	granulocyte	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
27	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2035
# text = From these results, we conclude that CD38 is ATRA inducible in myeloid leukemia cells and normal CD34+ bone marrow cells.
1	From	from	ADP	IN	_	_	_	_	_
2	these	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
3	results	result	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	,	,	PUNCT	,	_	_	_	_	_
5	we	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
6	conclude	conclude	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
7	that	that	SCONJ	IN	_	_	_	_	_
8	CD38	CD38	PROPN	NNP	Number=Sing	_	_	_	_
9	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
10	ATRA	ATRa	ADV	RB	_	_	_	_	_
11	inducible	inducible	ADJ	JJ	Degree=Pos	_	_	_	_
12	in	in	ADP	IN	_	_	_	_	_
13	myeloid	myeloid	ADJ	JJ	Degree=Pos	_	_	_	_
14	leukemia	leukemia	NOUN	NN	Number=Sing	_	_	_	_
15	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
16	and	and	CCONJ	CC	_	_	_	_	_
17	normal	normal	ADJ	JJ	Degree=Pos	_	_	_	_
18	CD34	Cd34	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
19	+	+	SYM	SYM	_	_	_	_	_
20	bone	bone	ADJ	JJ	Degree=Pos	_	_	_	_
21	marrow	marrow	ADJ	JJ	Degree=Pos	_	_	_	_
22	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
23	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2036
# text = This effect is independent of differentiation and is mediated by RAR alpha in HL-60 cells, suggesting a similar role for RAR alpha in CD38 expression in other hematopoietic cells.
1	This	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
2	effect	effect	NOUN	NN	Number=Sing	_	_	_	_
3	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
4	independent	independent	ADJ	JJ	Degree=Pos	_	_	_	_
5	of	of	ADP	IN	_	_	_	_	_
6	differentiation	differentiation	NOUN	NN	Number=Sing	_	_	_	_
7	and	and	CCONJ	CC	_	_	_	_	_
8	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
9	mediated	mediate	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
10	by	by	ADP	IN	_	_	_	_	_
11	RAR	RAR	PROPN	NNP	Number=Sing	_	_	_	_
12	alpha	alpha	ADV	RB	_	_	_	_	_
13	in	in	ADP	IN	_	_	_	_	_
14	HL	HL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
15	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
16	60	60	NUM	CD	NumType=Card	_	_	_	_
17	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
18	,	,	PUNCT	,	_	_	_	_	_
19	suggesting	suggest	VERB	VBG	VerbForm=Ger	_	_	_	_
20	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
21	similar	similar	ADJ	JJ	Degree=Pos	_	_	_	_
22	role	role	NOUN	NN	Number=Sing	_	_	_	_
23	for	for	ADP	IN	_	_	_	_	_
24	RAR	RAR	PROPN	NNP	Number=Sing	_	_	_	_
25	alpha	alpha	PROPN	NNP	Number=Sing	_	_	_	_
26	in	in	ADP	IN	_	_	_	_	_
27	CD38	CD38	PROPN	NNP	Number=Sing	_	_	_	_
28	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
29	in	in	ADP	IN	_	_	_	_	_
30	other	other	ADJ	JJ	Degree=Pos	_	_	_	_
31	hematopoietic	hematopoietic	ADJ	JJ	Degree=Pos	_	_	_	_
32	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
33	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 2037
# text = Document 003003119 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	003003119	003003119	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 2038
# text = Altered memory T cell differentiation in patients with early rheumatoid arthritis.
1	Altered	alter	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
2	memory	memory	NOUN	NN	Number=Sing	_	_	_	_
3	T	t	NUM	CD	NumType=Card	_	_	_	_
4	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
5	differentiation	differentiation	NOUN	NN	Number=Sing	_	_	_	_
6	in	in	ADP	IN	_	_	_	_	_
7	patients	patient	NOUN	NNS	Number=Plur	_	_	_	_
8	with	with	ADP	IN	_	_	_	_	_
9	early	early	ADJ	JJ	Degree=Pos	_	_	_	_
10	rheumatoid	rheumatoid	ADJ	JJ	Degree=Pos	_	_	_	_
11	arthritis	arthritis	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
12	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 2039
# text = The chronic immune response in rheumatoid arthritis (RA) might be driven by activated Th1 cells without sufficient Th2 cell differentiation to down-modulate inflammation.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	chronic	chronic	ADJ	JJ	Degree=Pos	_	_	_	_
3	immune	immune	ADJ	JJ	Degree=Pos	_	_	_	_
4	response	response	NOUN	NN	Number=Sing	_	_	_	_
5	in	in	ADP	IN	_	_	_	_	_
6	rheumatoid	rheumatoid	ADJ	JJ	Degree=Pos	_	_	_	_
7	arthritis	arthritis	NOUN	NN	Number=Sing	_	_	_	_
8	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
9	RA	RA	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
10	)	)	PUNCT	-RRB-	_	_	_	_	_
11	might	might	AUX	MD	VerbForm=Fin	_	_	_	_
12	be	be	AUX	VB	VerbForm=Inf	_	_	_	_
13	driven	drive	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
14	by	by	ADP	IN	_	_	_	_	_
15	activated	activate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
16	Th1	Th1	NUM	CD	NumType=Card	_	_	_	_
17	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
18	without	without	ADP	IN	_	_	_	_	_
19	sufficient	sufficient	ADJ	JJ	Degree=Pos	_	_	_	_
20	Th2	th2	NUM	CD	NumType=Card	_	_	_	_
21	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
22	differentiation	differentiation	NOUN	NN	Number=Sing	_	_	_	_
23	to	to	ADP	IN	_	_	_	_	_
24	down	down	ADV	RB	_	_	_	_	SpaceAfter=No
25	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
26	modulate	modulate	ADJ	JJ	Degree=Pos	_	_	_	_
27	inflammation	inflammation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
28	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2040
# text = To test whether disordered memory T cell differentiation contributes to the typical Th1-dominated chronic inflammation in RA we investigated differentiation of resting CD4+ memory T cells in patients with early (6 wk to 12 mo) untreated RA and in age- and sex-matched healthy controls in vitro.
1	To	to	PART	TO	_	_	_	_	_
2	test	test	VERB	VB	VerbForm=Inf	_	_	_	_
3	whether	whether	SCONJ	IN	_	_	_	_	_
4	disordered	disorder	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
5	memory	memory	NOUN	NN	Number=Sing	_	_	_	_
6	T	t	NUM	CD	NumType=Card	_	_	_	_
7	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
8	differentiation	differentiation	NOUN	NN	Number=Sing	_	_	_	_
9	contributes	contribute	NOUN	NNS	Number=Plur	_	_	_	_
10	to	to	ADP	IN	_	_	_	_	_
11	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
12	typical	typical	ADJ	JJ	Degree=Pos	_	_	_	_
13	Th1	th1	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
14	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
15	dominated	dominate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
16	chronic	chronic	ADJ	JJ	Degree=Pos	_	_	_	_
17	inflammation	inflammation	NOUN	NN	Number=Sing	_	_	_	_
18	in	in	ADP	IN	_	_	_	_	_
19	RA	RA	PROPN	NNP	Number=Sing	_	_	_	_
20	we	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
21	investigated	investigate	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
22	differentiation	differentiation	NOUN	NN	Number=Sing	_	_	_	_
23	of	of	SCONJ	IN	_	_	_	_	_
24	resting	rest	VERB	VBG	VerbForm=Ger	_	_	_	_
25	CD4	CD4	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
26	+	+	SYM	SYM	_	_	_	_	_
27	memory	memory	NOUN	NN	Number=Sing	_	_	_	_
28	T	t	PROPN	NNP	Number=Sing	_	_	_	_
29	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
30	in	in	ADP	IN	_	_	_	_	_
31	patients	patient	NOUN	NNS	Number=Plur	_	_	_	_
32	with	with	ADP	IN	_	_	_	_	_
33	early	early	ADV	RB	Degree=Pos	_	_	_	_
34	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
35	6	6	NUM	CD	NumType=Card	_	_	_	_
36	wk	wk	NOUN	NN	Number=Sing	_	_	_	_
37	to	to	ADP	IN	_	_	_	_	_
38	12	12	NUM	CD	NumType=Card	_	_	_	_
39	mo	mo	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
40	)	)	PUNCT	-RRB-	_	_	_	_	_
41	untreated	untreated	ADJ	JJ	Degree=Pos	_	_	_	_
42	RA	RA	PROPN	NNP	Number=Sing	_	_	_	_
43	and	and	CCONJ	CC	_	_	_	_	_
44	in	in	ADP	IN	_	_	_	_	_
45	age	age	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
46	-	-	PUNCT	,	_	_	_	_	_
47	and	and	CCONJ	CC	_	_	_	_	_
48	sex	sex	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
49	-matched	-match	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
50	healthy	healthy	ADJ	JJ	Degree=Pos	_	_	_	_
51	controls	control	NOUN	NNS	Number=Plur	_	_	_	_
52	in	in	ADP	IN	_	_	_	_	_
53	vitro	vitro	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
54	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2041
# text = No difference in cytokine secretion profiles of freshly isolated memory T cells was detected between patients and controls.
1	No	no	DET	DT	_	_	_	_	_
2	difference	difference	NOUN	NN	Number=Sing	_	_	_	_
3	in	in	ADP	IN	_	_	_	_	_
4	cytokine	cytokine	ADJ	JJ	Degree=Pos	_	_	_	_
5	secretion	secretion	NOUN	NN	Number=Sing	_	_	_	_
6	profiles	profile	NOUN	NNS	Number=Plur	_	_	_	_
7	of	of	ADP	IN	_	_	_	_	_
8	freshly	freshly	ADV	RB	_	_	_	_	_
9	isolated	isolate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
10	memory	memory	NOUN	NN	Number=Sing	_	_	_	_
11	T	t	NUM	CD	NumType=Card	_	_	_	_
12	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
13	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
14	detected	detect	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
15	between	between	ADP	IN	_	_	_	_	_
16	patients	patient	NOUN	NNS	Number=Plur	_	_	_	_
17	and	and	CCONJ	CC	_	_	_	_	_
18	controls	control	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
19	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2042
# text = A cell culture system was then employed that permitted the differentiation of Th effectors from resting memory T cells by short term priming.
1	A	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
2	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
3	culture	culture	NOUN	NN	Number=Sing	_	_	_	_
4	system	system	NOUN	NN	Number=Sing	_	_	_	_
5	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
6	then	then	ADV	RB	PronType=Dem	_	_	_	_
7	employed	employ	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
8	that	that	SCONJ	IN	_	_	_	_	_
9	permitted	permit	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
10	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
11	differentiation	differentiation	NOUN	NN	Number=Sing	_	_	_	_
12	of	of	ADP	IN	_	_	_	_	_
13	Th	th	PROPN	NNP	Number=Sing	_	_	_	_
14	effectors	effector	NOUN	NNS	Number=Plur	_	_	_	_
15	from	from	SCONJ	IN	_	_	_	_	_
16	resting	rest	VERB	VBG	VerbForm=Ger	_	_	_	_
17	memory	memory	NOUN	NN	Number=Sing	_	_	_	_
18	T	t	PROPN	NNP	Number=Sing	_	_	_	_
19	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
20	by	by	ADP	IN	_	_	_	_	_
21	short	short	ADJ	JJ	Degree=Pos	_	_	_	_
22	term	term	NOUN	NN	Number=Sing	_	_	_	_
23	priming	priming	VERB	VBG	VerbForm=Ger	_	_	_	SpaceAfter=No
24	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2043
# text = Marked differences were found in response to priming.
1	Marked	marked	ADJ	JJ	Degree=Pos	_	_	_	_
2	differences	difference	NOUN	NNS	Number=Plur	_	_	_	_
3	were	be	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
4	found	find	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
5	in	in	ADP	IN	_	_	_	_	_
6	response	response	NOUN	NN	Number=Sing	_	_	_	_
7	to	to	SCONJ	IN	_	_	_	_	_
8	priming	priming	VERB	VBG	VerbForm=Ger	_	_	_	SpaceAfter=No
9	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2044
# text = Th2 cells could be induced in all healthy controls by priming with anti-CD28 in the absence of TCR ligation.
1	Th2	Th2	NUM	CD	NumType=Card	_	_	_	_
2	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
3	could	could	AUX	MD	VerbForm=Fin	_	_	_	_
4	be	be	AUX	VB	VerbForm=Inf	_	_	_	_
5	induced	induce	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
6	in	in	ADP	IN	_	_	_	_	_
7	all	all	DET	DT	_	_	_	_	_
8	healthy	healthy	ADJ	JJ	Degree=Pos	_	_	_	_
9	controls	control	NOUN	NNS	Number=Plur	_	_	_	_
10	by	by	SCONJ	IN	_	_	_	_	_
11	priming	prim	VERB	VBG	VerbForm=Ger	_	_	_	_
12	with	with	ADP	IN	_	_	_	_	_
13	anti-CD28	anti-cd28	NUM	CD	NumType=Card	_	_	_	_
14	in	in	ADP	IN	_	_	_	_	_
15	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
16	absence	absence	NOUN	NN	Number=Sing	_	_	_	_
17	of	of	ADP	IN	_	_	_	_	_
18	TCR	Tcr	NOUN	NN	Number=Sing	_	_	_	_
19	ligation	ligation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
20	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2045
# text = By contrast, priming under those conditions resulted in Th2 differentiation in only 9 of 24 RA patients.
1	By	by	ADP	IN	_	_	_	_	_
2	contrast	contrast	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
3	,	,	PUNCT	,	_	_	_	_	_
4	priming	priming	VERB	VBG	VerbForm=Ger	_	_	_	_
5	under	under	ADP	IN	_	_	_	_	_
6	those	those	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
7	conditions	condition	NOUN	NNS	Number=Plur	_	_	_	_
8	resulted	result	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
9	in	in	ADP	IN	_	_	_	_	_
10	Th2	Th2	NUM	CD	NumType=Card	_	_	_	_
11	differentiation	differentiation	NOUN	NN	Number=Sing	_	_	_	_
12	in	in	ADP	IN	_	_	_	_	_
13	only	only	ADV	RB	_	_	_	_	_
14	9	9	NUM	CD	NumType=Card	_	_	_	_
15	of	of	ADP	IN	_	_	_	_	_
16	24	24	NUM	CD	NumType=Card	_	_	_	_
17	RA	RA	PROPN	NNP	Number=Sing	_	_	_	_
18	patients	patient	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
19	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2046
# text = Exogenous IL-4 could overcome the apparent Th2 differentiation defect in seven patients but was without effect in the remaining eight patients.
1	Exogenous	Exogenous	PROPN	NNP	Number=Sing	_	_	_	_
2	IL	Il	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
3	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
4	4	4	NUM	CD	NumType=Card	_	_	_	_
5	could	could	AUX	MD	VerbForm=Fin	_	_	_	_
6	overcome	overcome	VERB	VB	VerbForm=Inf	_	_	_	_
7	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
8	apparent	apparent	ADJ	JJ	Degree=Pos	_	_	_	_
9	Th2	Th2	NOUN	NN	Number=Sing	_	_	_	_
10	differentiation	differentiation	NOUN	NN	Number=Sing	_	_	_	_
11	defect	defect	NOUN	NN	Number=Sing	_	_	_	_
12	in	in	ADP	IN	_	_	_	_	_
13	seven	seven	NUM	CD	NumType=Card	_	_	_	_
14	patients	patient	NOUN	NNS	Number=Plur	_	_	_	_
15	but	but	CCONJ	CC	_	_	_	_	_
16	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
17	without	without	ADP	IN	_	_	_	_	_
18	effect	effect	NOUN	NN	Number=Sing	_	_	_	_
19	in	in	ADP	IN	_	_	_	_	_
20	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
21	remaining	remaining	VERB	VBG	VerbForm=Ger	_	_	_	_
22	eight	eight	NUM	CD	NumType=Card	_	_	_	_
23	patients	patient	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
24	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2047
# text = In all patients a marked decrease in IL-2-producing cells and a significant increase in well-differentiated Th1 cells that produced IFN-gamma but not IL-2 were evident after priming with anti-CD3 and anti-CD28.
1	In	in	ADP	IN	_	_	_	_	_
2	all	all	DET	DT	_	_	_	_	_
3	patients	patient	NOUN	NNS	Number=Plur	_	_	_	_
4	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
5	marked	mark	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
6	decrease	decrease	NOUN	NN	Number=Sing	_	_	_	_
7	in	in	ADP	IN	_	_	_	_	_
8	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
9	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
10	2	2	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
11	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
12	producing	produce	VERB	VBG	VerbForm=Ger	_	_	_	_
13	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
14	and	and	CCONJ	CC	_	_	_	_	_
15	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
16	significant	significant	ADJ	JJ	Degree=Pos	_	_	_	_
17	increase	increase	NOUN	NN	Number=Sing	_	_	_	_
18	in	in	ADP	IN	_	_	_	_	_
19	well	well	ADV	RB	Degree=Pos	_	_	_	SpaceAfter=No
20	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
21	differentiated	differentiate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
22	Th1	th1	NUM	CD	NumType=Card	_	_	_	_
23	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
24	that	that	PRON	WDT	PronType=Rel	_	_	_	_
25	produced	produce	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
26	IFN	Ifn	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
27	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
28	gamma	gamma	NOUN	NN	Number=Sing	_	_	_	_
29	but	but	CCONJ	CC	_	_	_	_	_
30	not	not	PART	RB	_	_	_	_	_
31	IL	Il	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
32	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
33	2	2	NUM	CD	NumType=Card	_	_	_	_
34	were	be	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
35	evident	evident	ADJ	JJ	Degree=Pos	_	_	_	_
36	after	after	SCONJ	IN	_	_	_	_	_
37	priming	prim	VERB	VBG	VerbForm=Ger	_	_	_	_
38	with	with	ADP	IN	_	_	_	_	_
39	anti-CD3	anti-CD3	NOUN	NN	Number=Sing	_	_	_	_
40	and	and	CCONJ	CC	_	_	_	_	_
41	anti-CD28	anti-cd28	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
42	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2048
# text = The data suggest that CD4+ memory T cells from patients with early untreated RA manifest an intrinsic abnormality in their ability to differentiate into specific cytokine-producing effector cells that might contribute to the characteristic Th1-dominated chronic (auto)immune inflammation in RA.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	data	data	NOUN	NN	Number=Sing	_	_	_	_
3	suggest	suggest	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
4	that	that	SCONJ	IN	_	_	_	_	_
5	CD4	CD4	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
6	+	+	SYM	SYM	_	_	_	_	_
7	memory	memory	NOUN	NN	Number=Sing	_	_	_	_
8	T	t	NUM	CD	NumType=Card	_	_	_	_
9	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
10	from	from	ADP	IN	_	_	_	_	_
11	patients	patient	NOUN	NNS	Number=Plur	_	_	_	_
12	with	with	ADP	IN	_	_	_	_	_
13	early	early	ADJ	JJ	Degree=Pos	_	_	_	_
14	untreated	untreated	ADJ	JJ	Degree=Pos	_	_	_	_
15	RA	Ra	NOUN	NN	Number=Sing	_	_	_	_
16	manifest	manifest	ADV	RBS	Degree=Sup	_	_	_	_
17	an	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
18	intrinsic	intrinsic	ADJ	JJ	Degree=Pos	_	_	_	_
19	abnormality	abnormality	NOUN	NN	Number=Sing	_	_	_	_
20	in	in	ADP	IN	_	_	_	_	_
21	their	they	PRON	PRP$	Number=Plur|Person=3|Poss=Yes|PronType=Prs	_	_	_	_
22	ability	ability	NOUN	NN	Number=Sing	_	_	_	_
23	to	to	PART	TO	_	_	_	_	_
24	differentiate	differentiate	VERB	VB	VerbForm=Inf	_	_	_	_
25	into	into	ADP	IN	_	_	_	_	_
26	specific	specific	ADJ	JJ	Degree=Pos	_	_	_	_
27	cytokine	cytokine	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
28	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
29	producing	produce	VERB	VBG	VerbForm=Ger	_	_	_	_
30	effector	effector	NOUN	NN	Number=Sing	_	_	_	_
31	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
32	that	that	PRON	WDT	PronType=Rel	_	_	_	_
33	might	might	AUX	MD	VerbForm=Fin	_	_	_	_
34	contribute	contribute	VERB	VB	VerbForm=Inf	_	_	_	_
35	to	to	ADP	IN	_	_	_	_	_
36	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
37	characteristic	characteristic	NOUN	NN	Number=Sing	_	_	_	_
38	Th1	th1	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
39	-	-	PUNCT	:	_	_	_	_	SpaceAfter=No
40	dominated	dominate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
41	chronic	chronic	NOUN	NN	Number=Sing	_	_	_	_
42	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
43	auto	auto	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
44	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
45	immune	immune	ADJ	JJ	Degree=Pos	_	_	_	_
46	inflammation	inflammation	NOUN	NN	Number=Sing	_	_	_	_
47	in	in	ADP	IN	_	_	_	_	_
48	RA	RA	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
49	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 2049
# text = Document 003003122 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	003003122	003003122	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 2050
# text = c-Myc and E1A induced cellular sensitivity to activated NK cells involves cytotoxic granules as death effectors.
1	c	class	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
2	-	-	PUNCT	:	_	_	_	_	SpaceAfter=No
3	Myc	Myc	PROPN	NNP	Number=Sing	_	_	_	_
4	and	and	CCONJ	CC	_	_	_	_	_
5	E1	E1	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
6	A	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
7	induced	induce	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
8	cellular	cellular	ADJ	JJ	Degree=Pos	_	_	_	_
9	sensitivity	sensitivity	NOUN	NN	Number=Sing	_	_	_	_
10	to	to	ADP	IN	_	_	_	_	_
11	activated	activated	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
12	NK	NK	PROPN	NNP	Number=Sing	_	_	_	_
13	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
14	involves	involve	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
15	cytotoxic	cytotoxic	ADJ	JJ	Degree=Pos	_	_	_	_
16	granules	granule	NOUN	NNS	Number=Plur	_	_	_	_
17	as	as	ADP	IN	_	_	_	_	_
18	death	death	NOUN	NN	Number=Sing	_	_	_	_
19	effectors	effector	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
20	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 2051
# text = The contact of natural killer (NK) cells with foreign cells and with certain virus-infected or tumor cells triggers the cytolytic machinery of NK cells.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	contact	contact	NOUN	NN	Number=Sing	_	_	_	_
3	of	of	ADP	IN	_	_	_	_	_
4	natural	natural	ADJ	JJ	Degree=Pos	_	_	_	_
5	killer	killer	NOUN	NN	Number=Sing	_	_	_	_
6	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
7	NK	NK	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
8	)	)	PUNCT	-RRB-	_	_	_	_	_
9	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
10	with	with	ADP	IN	_	_	_	_	_
11	foreign	foreign	ADJ	JJ	Degree=Pos	_	_	_	_
12	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
13	and	and	CCONJ	CC	_	_	_	_	_
14	with	with	ADP	IN	_	_	_	_	_
15	certain	certain	ADJ	JJ	Degree=Pos	_	_	_	_
16	virus	virus	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
17	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
18	infected	infect	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
19	or	or	CCONJ	CC	_	_	_	_	_
20	tumor	tumor	NOUN	NN	Number=Sing	_	_	_	_
21	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
22	triggers	trigger	NOUN	NNS	Number=Plur	_	_	_	_
23	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
24	cytolytic	cytolytic	ADJ	JJ	Degree=Pos	_	_	_	_
25	machinery	machinery	NOUN	NN	Number=Sing	_	_	_	_
26	of	of	ADP	IN	_	_	_	_	_
27	NK	NK	PROPN	NNP	Number=Sing	_	_	_	_
28	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
29	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2052
# text = This triggering leads to exocytosis of the cytotoxic NK cell granules.
1	This	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
2	triggering	triggering	NOUN	NN	Number=Sing	_	_	_	_
3	leads	lead	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
4	to	to	ADP	IN	_	_	_	_	_
5	exocytosis	exocytosis	PRON	DT	Number=Sing|PronType=Dem	_	_	_	_
6	of	of	ADP	IN	_	_	_	_	_
7	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
8	cytotoxic	cytotoxic	ADJ	JJ	Degree=Pos	_	_	_	_
9	NK	NK	PROPN	NNP	Number=Sing	_	_	_	_
10	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
11	granules	granule	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
12	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2053
# text = The oncoproteins c-Myc and E1A render cells vulnerable to NK cell mediated cytolysis yet the mechanisms of sensitization are not well understood.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	oncoproteins	oncoprotein	NOUN	NNS	Number=Plur	_	_	_	_
3	c-	c-	PUNCT	,	_	_	_	_	SpaceAfter=No
4	Myc	Myc	PROPN	NNP	Number=Sing	_	_	_	_
5	and	and	CCONJ	CC	_	_	_	_	_
6	E1	E1	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
7	A	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
8	render	render	NOUN	NN	Number=Sing	_	_	_	_
9	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
10	vulnerable	vulnerable	ADJ	JJ	Degree=Pos	_	_	_	_
11	to	to	ADP	IN	_	_	_	_	_
12	NK	Nk	PROPN	NNP	Number=Sing	_	_	_	_
13	cell	cell	PROPN	NNP	Number=Sing	_	_	_	_
14	mediated	mediate	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
15	cytolysis	cytolysis	NOUN	NN	Number=Sing	_	_	_	_
16	yet	yet	CCONJ	CC	_	_	_	_	_
17	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
18	mechanisms	mechanism	NOUN	NNS	Number=Plur	_	_	_	_
19	of	of	ADP	IN	_	_	_	_	_
20	sensitization	sensitization	NOUN	NN	Number=Sing	_	_	_	_
21	are	be	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
22	not	not	PART	RB	_	_	_	_	_
23	well	well	ADV	RB	Degree=Pos	_	_	_	_
24	understood	understand	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	SpaceAfter=No
25	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2054
# text = In a model where foreign cells (rat fibroblasts) were cocultured with human IL-2 activated NK cells, we observed that NK cells were capable of efficiently killing their targets only if the cells overexpressed the oncogene c-Myc or E1A.
1	In	in	ADP	IN	_	_	_	_	_
2	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
3	model	model	NOUN	NN	Number=Sing	_	_	_	_
4	where	where	ADV	WRB	PronType=Rel	_	_	_	_
5	foreign	foreign	ADJ	JJ	Degree=Pos	_	_	_	_
6	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
7	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
8	rat	rat	NOUN	NN	Number=Sing	_	_	_	_
9	fibroblasts	fibroblast	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
10	)	)	PUNCT	-RRB-	_	_	_	_	_
11	were	be	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
12	cocultured	coculture	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
13	with	with	ADP	IN	_	_	_	_	_
14	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
15	IL	Il	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
16	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
17	2	2	NUM	CD	NumType=Card	_	_	_	_
18	activated	activate	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
19	NK	Nk	PROPN	NNP	Number=Sing	_	_	_	_
20	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
21	,	,	PUNCT	,	_	_	_	_	_
22	we	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
23	observed	observe	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
24	that	that	SCONJ	IN	_	_	_	_	_
25	NK	NK	PROPN	NNP	Number=Sing	_	_	_	_
26	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
27	were	be	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
28	capable	capable	ADJ	JJ	Degree=Pos	_	_	_	_
29	of	of	SCONJ	IN	_	_	_	_	_
30	efficiently	efficiently	ADV	RB	_	_	_	_	_
31	killing	kill	VERB	VBG	VerbForm=Ger	_	_	_	_
32	their	they	PRON	PRP$	Number=Plur|Person=3|Poss=Yes|PronType=Prs	_	_	_	_
33	targets	target	NOUN	NNS	Number=Plur	_	_	_	_
34	only	only	ADV	RB	_	_	_	_	_
35	if	if	SCONJ	IN	_	_	_	_	_
36	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
37	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
38	overexpressed	overexpress	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
39	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
40	oncogene	oncogene	ADJ	JJ	Degree=Pos	_	_	_	_
41	c	c	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
42	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
43	Myc	Myc	PROPN	NNP	Number=Sing	_	_	_	_
44	or	or	CCONJ	CC	_	_	_	_	_
45	E1A	E1A	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
46	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2055
# text = Both the parental and the oncogene expressing fibroblasts similarly triggered phosphoinositide hydrolysis in the bound NK cells, demonstrating that NK cells were cytolytically activated in contact with both resistant parental and oncogene expressing sensitive target fibroblasts.
1	Both	both	CCONJ	CC	_	_	_	_	_
2	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
3	parental	parental	NOUN	NN	Number=Sing	_	_	_	_
4	and	and	CCONJ	CC	_	_	_	_	_
5	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
6	oncogene	oncogene	NOUN	NN	Number=Sing	_	_	_	_
7	expressing	express	VERB	VBG	VerbForm=Ger	_	_	_	_
8	fibroblasts	fibroblast	NOUN	NNS	Number=Plur	_	_	_	_
9	similarly	similarly	ADV	RB	_	_	_	_	_
10	triggered	trigger	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
11	phosphoinositide	phosphoinositide	NOUN	NN	Number=Sing	_	_	_	_
12	hydrolysis	hydrolysis	NOUN	NN	Number=Sing	_	_	_	_
13	in	in	ADP	IN	_	_	_	_	_
14	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
15	bound	bound	ADJ	JJ	Degree=Pos	_	_	_	_
16	NK	Nk	PROPN	NNP	Number=Sing	_	_	_	_
17	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
18	,	,	PUNCT	,	_	_	_	_	_
19	demonstrating	demonstrat	VERB	VBG	VerbForm=Ger	_	_	_	_
20	that	that	SCONJ	IN	_	_	_	_	_
21	NK	NK	PROPN	NNP	Number=Sing	_	_	_	_
22	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
23	were	be	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
24	cytolytically	cytolytically	ADV	RB	_	_	_	_	_
25	activated	activate	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
26	in	in	ADP	IN	_	_	_	_	_
27	contact	contact	NOUN	NN	Number=Sing	_	_	_	_
28	with	with	ADP	IN	_	_	_	_	_
29	both	both	DET	DT	_	_	_	_	_
30	resistant	resistant	NOUN	NN	Number=Sing	_	_	_	_
31	parental	parental	NOUN	NN	Number=Sing	_	_	_	_
32	and	and	CCONJ	CC	_	_	_	_	_
33	oncogene	oncogene	ADV	RB	_	_	_	_	_
34	expressing	expresse	VERB	VBG	VerbForm=Ger	_	_	_	_
35	sensitive	sensitive	ADJ	JJ	Degree=Pos	_	_	_	_
36	target	target	NOUN	NN	Number=Sing	_	_	_	_
37	fibroblasts	fibroblast	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
38	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2056
# text = The cell death was independent of wild-type p53 and was not inhibited by an anti-apoptotic protein EIB19K.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
3	death	death	NOUN	NN	Number=Sing	_	_	_	_
4	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
5	independent	independent	ADJ	JJ	Degree=Pos	_	_	_	_
6	of	of	ADP	IN	_	_	_	_	_
7	wild	wild	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
8	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
9	type	type	NOUN	NN	Number=Sing	_	_	_	_
10	p53	p53	NOUN	NN	Number=Sing	_	_	_	_
11	and	and	CCONJ	CC	_	_	_	_	_
12	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
13	not	not	PART	RB	_	_	_	_	_
14	inhibited	inhibit	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
15	by	by	ADP	IN	_	_	_	_	_
16	an	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
17	anti-apoptotic	anti-apoptotic	ADJ	JJ	Degree=Pos	_	_	_	_
18	protein	protein	NOUN	NN	Number=Sing	_	_	_	_
19	EIB	EIB	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
20	19K	19K	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
21	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2057
# text = These results provided evidence that c-Myc and E1A activated the NK cell induced cytolysis at a post-triggering stage of NK cell-target cell interaction.
1	These	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
2	results	result	NOUN	NNS	Number=Plur	_	_	_	_
3	provided	provide	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
4	evidence	evidence	NOUN	NN	Number=Sing	_	_	_	_
5	that	that	SCONJ	IN	_	_	_	_	_
6	c-	c-	SYM	NFP	_	_	_	_	SpaceAfter=No
7	Myc	Myc	PROPN	NNP	Number=Sing	_	_	_	_
8	and	and	CCONJ	CC	_	_	_	_	_
9	E1	E1	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
10	A	A	PROPN	NNP	Number=Sing	_	_	_	_
11	activated	activate	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
12	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
13	NK	NK	PROPN	NNP	Number=Sing	_	_	_	_
14	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
15	induced	induce	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
16	cytolysis	cytolysis	NOUN	NN	Number=Sing	_	_	_	_
17	at	at	ADP	IN	_	_	_	_	_
18	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
19	post	post	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
20	-triggering	-trigger	VERB	VBG	VerbForm=Ger	_	_	_	_
21	stage	stage	NOUN	NN	Number=Sing	_	_	_	_
22	of	of	ADP	IN	_	_	_	_	_
23	NK	NK	PROPN	NNP	Number=Sing	_	_	_	_
24	cell	cell	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
25	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
26	target	target	NOUN	NN	Number=Sing	_	_	_	_
27	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
28	interaction	interaction	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
29	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2058
# text = In consistence, the c-Myc and E1A overexpressing fibroblasts were more sensitive to the cytolytic effects of isolated NK cell-derived granules than parental cells.
1	In	in	ADP	IN	_	_	_	_	_
2	consistence	consistence	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
3	,	,	PUNCT	,	_	_	_	_	_
4	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
5	c	c	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
6	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
7	Myc	Myc	PROPN	NNP	Number=Sing	_	_	_	_
8	and	and	CCONJ	CC	_	_	_	_	_
9	E1A	E1A	PROPN	NNP	Number=Sing	_	_	_	_
10	overexpressing	overexpresse	ADJ	JJ	Degree=Pos	_	_	_	_
11	fibroblasts	fibroblast	NOUN	NNS	Number=Plur	_	_	_	_
12	were	be	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
13	more	more	ADV	RBR	_	_	_	_	_
14	sensitive	sensitive	ADJ	JJ	Degree=Pos	_	_	_	_
15	to	to	ADP	IN	_	_	_	_	_
16	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
17	cytolytic	cytolytic	ADJ	JJ	Degree=Pos	_	_	_	_
18	effects	effect	NOUN	NNS	Number=Plur	_	_	_	_
19	of	of	ADP	IN	_	_	_	_	_
20	isolated	isolate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
21	NK	NK	PROPN	NNP	Number=Sing	_	_	_	_
22	cell	cell	ADV	RB	Degree=Pos	_	_	_	SpaceAfter=No
23	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
24	derived	derive	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
25	granules	granule	NOUN	NNS	Number=Plur	_	_	_	_
26	than	than	ADP	IN	_	_	_	_	_
27	parental	parental	ADJ	JJ	Degree=Pos	_	_	_	_
28	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
29	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2059
# text = The data indicate that oncogenes activate the cytotoxicity of NK cell granules.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	data	data	NOUN	NN	Number=Sing	_	_	_	_
3	indicate	indicate	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
4	that	that	SCONJ	IN	_	_	_	_	_
5	oncogenes	oncogene	NOUN	NNS	Number=Plur	_	_	_	_
6	activate	activate	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
7	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
8	cytotoxicity	cytotoxicity	NOUN	NN	Number=Sing	_	_	_	_
9	of	of	ADP	IN	_	_	_	_	_
10	NK	NK	PROPN	NNP	Number=Sing	_	_	_	_
11	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
12	granules	granule	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
13	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2060
# text = This mechanism can have a role in directing the cytolytic action of NK cells towards the virus-infected and cancer cells.
1	This	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
2	mechanism	mechanism	NOUN	NN	Number=Sing	_	_	_	_
3	can	can	AUX	MD	VerbForm=Fin	_	_	_	_
4	have	have	VERB	VB	VerbForm=Inf	_	_	_	_
5	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
6	role	role	NOUN	NN	Number=Sing	_	_	_	_
7	in	in	SCONJ	IN	_	_	_	_	_
8	directing	direct	VERB	VBG	VerbForm=Ger	_	_	_	_
9	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
10	cytolytic	cytolytic	ADJ	JJ	Degree=Pos	_	_	_	_
11	action	action	NOUN	NN	Number=Sing	_	_	_	_
12	of	of	ADP	IN	_	_	_	_	_
13	NK	NK	PROPN	NNP	Number=Sing	_	_	_	_
14	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
15	towards	towards	ADP	IN	_	_	_	_	_
16	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
17	virus	virus	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
18	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
19	infected	infect	ADJ	JJ	Degree=Pos	_	_	_	_
20	and	and	CCONJ	CC	_	_	_	_	_
21	cancer	cancer	NOUN	NN	Number=Sing	_	_	_	_
22	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
23	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 2061
# text = Document 003003125 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	003003125	003003125	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 2062
# text = Lymphocyte glucocorticoid receptor: predictor of sertraline response in adolescent major depressive disorder (MDD).
1	Lymphocyte	Lymphocyte	ADJ	JJ	Degree=Pos	_	_	_	_
2	glucocorticoid	glucocorticoid	NOUN	NN	Number=Sing	_	_	_	_
3	receptor	receptor	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
4	:	:	PUNCT	:	_	_	_	_	_
5	predictor	predictor	NOUN	NN	Number=Sing	_	_	_	_
6	of	of	ADP	IN	_	_	_	_	_
7	sertraline	sertraline	NOUN	NN	Number=Sing	_	_	_	_
8	response	response	NOUN	NN	Number=Sing	_	_	_	_
9	in	in	ADP	IN	_	_	_	_	_
10	adolescent	adolescent	ADJ	JJ	Degree=Pos	_	_	_	_
11	major	major	ADJ	JJ	Degree=Pos	_	_	_	_
12	depressive	depressive	ADJ	JJ	Degree=Pos	_	_	_	_
13	disorder	disorder	NOUN	NN	Number=Sing	_	_	_	_
14	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
15	MDD	MDD	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
16	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
17	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 2063
# text = Major depressive disorder (MDD) in adolescents demonstrates resistance to tricyclic antidepressants and absence of hypercortisolemia.
1	Major	major	ADJ	JJ	Degree=Pos	_	_	_	_
2	depressive	depressive	ADJ	JJ	Degree=Pos	_	_	_	_
3	disorder	disorder	NOUN	NN	Number=Sing	_	_	_	_
4	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
5	MDD	MDD	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
6	)	)	PUNCT	-RRB-	_	_	_	_	_
7	in	in	ADP	IN	_	_	_	_	_
8	adolescents	adolescent	NOUN	NNS	Number=Plur	_	_	_	_
9	demonstrates	demonstrate	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
10	resistance	resistance	NOUN	NN	Number=Sing	_	_	_	_
11	to	to	ADP	IN	_	_	_	_	_
12	tricyclic	tricyclic	ADJ	JJ	Degree=Pos	_	_	_	_
13	antidepressants	antidepressant	NOUN	NNS	Number=Plur	_	_	_	_
14	and	and	CCONJ	CC	_	_	_	_	_
15	absence	absence	NOUN	NN	Number=Sing	_	_	_	_
16	of	of	ADP	IN	_	_	_	_	_
17	hypercortisolemia	hypercortisolemion	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
18	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2064
# text = The efficacy of serotonin reuptake inhibitors (SRIs) is uncertain, and response predictors are unavailable.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	efficacy	efficacy	NOUN	NN	Number=Sing	_	_	_	_
3	of	of	ADP	IN	_	_	_	_	_
4	serotonin	serotonin	ADJ	JJ	Degree=Pos	_	_	_	_
5	reuptake	reuptake	NOUN	NN	Number=Sing	_	_	_	_
6	inhibitors	inhibitor	NOUN	NNS	Number=Plur	_	_	_	_
7	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
8	SRIs	SRIs	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
9	)	)	PUNCT	-RRB-	_	_	_	_	_
10	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
11	uncertain	uncertain	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
12	,	,	PUNCT	,	_	_	_	_	_
13	and	and	CCONJ	CC	_	_	_	_	_
14	response	response	NOUN	NN	Number=Sing	_	_	_	_
15	predictors	predictor	NOUN	NNS	Number=Plur	_	_	_	_
16	are	be	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
17	unavailable	unavailable	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
18	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2065
# text = Abnormal fast feedback and negative feedback of the hypothalamic-pituitary-adrenal axis implicates a dampened limbic-hippocampal glucocorticoid type II receptor (GCII).
1	Abnormal	abnormal	ADJ	JJ	Degree=Pos	_	_	_	_
2	fast	fast	ADJ	JJ	Degree=Pos	_	_	_	_
3	feedback	feedback	NOUN	NN	Number=Sing	_	_	_	_
4	and	and	CCONJ	CC	_	_	_	_	_
5	negative	negative	ADJ	JJ	Degree=Pos	_	_	_	_
6	feedback	feedback	NOUN	NN	Number=Sing	_	_	_	_
7	of	of	ADP	IN	_	_	_	_	_
8	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
9	hypothalamic	hypothalamic	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
10	-pituitary-adrenal	-pituitary-adrenal	ADJ	JJ	Degree=Pos	_	_	_	_
11	axis	axis	NOUN	NN	Number=Sing	_	_	_	_
12	implicates	implicate	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
13	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
14	dampened	dampen	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
15	limbic	limbic	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
16	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
17	hippocampal	hippocampal	ADJ	JJ	Degree=Pos	_	_	_	_
18	glucocorticoid	glucocorticoid	NOUN	NN	Number=Sing	_	_	_	_
19	type	type	NOUN	NN	Number=Sing	_	_	_	_
20	II	ii	NUM	CD	NumType=Card	_	_	_	_
21	receptor	receptor	NOUN	NN	Number=Sing	_	_	_	_
22	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
23	GCII	GCII	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
24	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
25	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2066
# text = We hypothesized that lymphocyte GCII is altered in adolescent MDD and could serve as a marker for response to SRIs.
1	We	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
2	hypothesized	hypothesize	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
3	that	that	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
4	lymphocyte	lymphocyte	NOUN	NN	Number=Sing	_	_	_	_
5	GCII	GCII	NOUN	NN	Number=Sing	_	_	_	_
6	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
7	altered	alter	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
8	in	in	ADP	IN	_	_	_	_	_
9	adolescent	adolescent	ADJ	JJ	Degree=Pos	_	_	_	_
10	MDD	mdd	NOUN	NN	Number=Sing	_	_	_	_
11	and	and	CCONJ	CC	_	_	_	_	_
12	could	could	AUX	MD	VerbForm=Fin	_	_	_	_
13	serve	serve	VERB	VB	VerbForm=Inf	_	_	_	_
14	as	as	ADP	IN	_	_	_	_	_
15	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
16	marker	marker	NOUN	NN	Number=Sing	_	_	_	_
17	for	for	ADP	IN	_	_	_	_	_
18	response	response	NOUN	NN	Number=Sing	_	_	_	_
19	to	to	ADP	IN	_	_	_	_	_
20	SRIs	SRIs	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
21	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2067
# text = In an open-label study, adolescents (n = 20) meeting DSM-III-R criteria for MDD showed baseline lymphocyte GCII sites per cell (sites/cell) values of 793 +/- 106 versus 2,563 +/- 499 (+/- SEM) for matched controls (n = 18) (t = 3.5; df = 36; p < .001).
1	In	in	ADP	IN	_	_	_	_	_
2	an	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
3	open	open	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
4	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
5	label	label	NOUN	NN	Number=Sing	_	_	_	_
6	study	study	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
7	,	,	PUNCT	,	_	_	_	_	_
8	adolescents	adolescent	NOUN	NNS	Number=Plur	_	_	_	_
9	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
10	n	not	NOUN	NN	Number=Sing	_	_	_	_
11	=	=	SYM	SYM	_	_	_	_	_
12	20	20	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
13	)	)	PUNCT	-RRB-	_	_	_	_	_
14	meeting	meet	NOUN	NN	Number=Sing	_	_	_	_
15	DSM	DSM	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
16	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
17	III	III	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
18	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
19	R	R	PROPN	NNP	Number=Sing	_	_	_	_
20	criteria	criteria	NOUN	NN	Number=Sing	_	_	_	_
21	for	for	ADP	IN	_	_	_	_	_
22	MDD	MDD	PROPN	NNP	Number=Sing	_	_	_	_
23	showed	show	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
24	baseline	baseline	NOUN	NN	Number=Sing	_	_	_	_
25	lymphocyte	lymphocyte	NOUN	NN	Number=Sing	_	_	_	_
26	GCII	Gcii	NUM	CD	NumType=Card	_	_	_	_
27	sites	site	NOUN	NNS	Number=Plur	_	_	_	_
28	per	per	ADP	IN	_	_	_	_	_
29	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
30	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
31	sites	site	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
32	/	/	PUNCT	,	_	_	_	_	SpaceAfter=No
33	cell	cell	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
34	)	)	PUNCT	-RRB-	_	_	_	_	_
35	values	value	NOUN	NNS	Number=Plur	_	_	_	_
36	of	of	ADP	IN	_	_	_	_	_
37	793	793	NUM	CD	NumType=Card	_	_	_	_
38	+/-	+/-	SYM	SYM	_	_	_	_	_
39	106	106	NUM	CD	NumType=Card	_	_	_	_
40	versus	versus	ADP	IN	_	_	_	_	_
41	2,563	2,563	NUM	CD	NumType=Card	_	_	_	_
42	+/-	+/-	SYM	SYM	_	_	_	_	_
43	499	499	NUM	CD	NumType=Card	_	_	_	_
44	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
45	+/-	+/-	SYM	NFP	_	_	_	_	_
46	SEM	SEM	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
47	)	)	PUNCT	-RRB-	_	_	_	_	_
48	for	for	ADP	IN	_	_	_	_	_
49	matched	match	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
50	controls	control	NOUN	NNS	Number=Plur	_	_	_	_
51	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
52	n	not	NOUN	NN	Number=Sing	_	_	_	_
53	=	=	SYM	SYM	_	_	_	_	_
54	18	18	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
55	)	)	PUNCT	-RRB-	_	_	_	_	_
56	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
57	t	t	NOUN	NN	Number=Sing	_	_	_	_
58	=	=	SYM	SYM	_	_	_	_	_
59	3.5	3.5	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
60	;	;	PUNCT	,	_	_	_	_	_
61	df	df	NOUN	NN	Number=Sing	_	_	_	_
62	=	=	SYM	SYM	_	_	_	_	_
63	36	36	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
64	;	;	PUNCT	,	_	_	_	_	_
65	p	p	NOUN	NN	Number=Sing	_	_	_	_
66	<	<	PUNCT	-LRB-	_	_	_	_	_
67	.001	.001	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
68	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
69	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2068
# text = GCII was bimodally distributed, with SRI responders differing from nonresponders (t = 3.9; df = 14; p < .001).
1	GCII	GCII	PRON	PRP	Case=Nom|Number=Sing|Person=1|PronType=Prs	_	_	_	_
2	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
3	bimodally	bimodally	ADV	RB	_	_	_	_	_
4	distributed	distribute	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	SpaceAfter=No
5	,	,	PUNCT	,	_	_	_	_	_
6	with	with	ADP	IN	_	_	_	_	_
7	SRI	Sri	NOUN	NN	Number=Sing	_	_	_	_
8	responders	responder	NOUN	NNS	Number=Plur	_	_	_	_
9	differing	differ	VERB	VBG	VerbForm=Ger	_	_	_	_
10	from	from	ADP	IN	_	_	_	_	_
11	nonresponders	nonresponder	NOUN	NNS	Number=Plur	_	_	_	_
12	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
13	t	t	NUM	CD	NumType=Card	_	_	_	_
14	=	=	SYM	SYM	_	_	_	_	_
15	3.9	3.9	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
16	;	;	PUNCT	,	_	_	_	_	_
17	df	df	NOUN	NN	Number=Sing	_	_	_	_
18	=	=	SYM	SYM	_	_	_	_	_
19	14	14	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
20	;	;	PUNCT	,	_	_	_	_	_
21	p	p	NOUN	NN	Number=Sing	_	_	_	_
22	<	<	PUNCT	-LRB-	_	_	_	_	_
23	.001	.001	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
24	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
25	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2069
# text = GCII accurately classified 90 percent of sertraline responders and 80 percent of nonresponders.
1	GCII	GCII	PRON	PRP	Case=Nom|Number=Sing|Person=1|PronType=Prs	_	_	_	_
2	accurately	accurately	ADV	RB	_	_	_	_	_
3	classified	classify	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
4	90	90	NUM	CD	NumType=Card	_	_	_	_
5	percent	percent	NOUN	NN	Number=Sing	_	_	_	_
6	of	of	ADP	IN	_	_	_	_	_
7	sertraline	sertraline	NOUN	NN	Number=Sing	_	_	_	_
8	responders	responder	NOUN	NNS	Number=Plur	_	_	_	_
9	and	and	CCONJ	CC	_	_	_	_	_
10	80	80	NUM	CD	NumType=Card	_	_	_	_
11	percent	percent	NOUN	NN	Number=Sing	_	_	_	_
12	of	of	ADP	IN	_	_	_	_	_
13	nonresponders	nonresponder	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
14	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2070
# text = Only SRI responders showed GCII sites/cell upregulated after 6 weeks of treatment (t = 2.1, df = 10; p < .05).
1	Only	only	ADV	RB	_	_	_	_	_
2	SRI	Sri	PROPN	NNP	Number=Sing	_	_	_	_
3	responders	responder	NOUN	NNS	Number=Plur	_	_	_	_
4	showed	show	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
5	GCII	Gcii	PROPN	NNP	Number=Sing	_	_	_	_
6	sites	site	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
7	/	/	PUNCT	,	_	_	_	_	SpaceAfter=No
8	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
9	upregulated	upregulate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
10	after	after	ADP	IN	_	_	_	_	_
11	6	6	NUM	CD	NumType=Card	_	_	_	_
12	weeks	week	NOUN	NNS	Number=Plur	_	_	_	_
13	of	of	ADP	IN	_	_	_	_	_
14	treatment	treatment	NOUN	NN	Number=Sing	_	_	_	_
15	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
16	t	t	NOUN	NN	Number=Sing	_	_	_	_
17	=	=	SYM	SYM	_	_	_	_	_
18	2.1	2.1	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
19	,	,	PUNCT	,	_	_	_	_	_
20	df	df	PROPN	NNP	Number=Sing	_	_	_	_
21	=	=	SYM	SYM	_	_	_	_	_
22	10	10	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
23	;	;	PUNCT	,	_	_	_	_	_
24	p	p	NOUN	NN	Number=Sing	_	_	_	_
25	<	<	PUNCT	-LRB-	_	_	_	_	_
26	.05	.05	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
27	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
28	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 2071
# text = Document 003003126 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	003003126	003003126	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 2072
# text = Transcriptional activity of core binding factor-alpha (AML1) and beta subunits on murine leukemia virus enhancer cores.
1	Transcriptional	Transcriptional	ADJ	JJ	Degree=Pos	_	_	_	_
2	activity	activity	NOUN	NN	Number=Sing	_	_	_	_
3	of	of	ADP	IN	_	_	_	_	_
4	core	core	NOUN	NN	Number=Sing	_	_	_	_
5	binding	bind	VERB	VBG	VerbForm=Ger	_	_	_	_
6	factor	factor	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
7	-alpha	-alpha	NOUN	NN	Number=Sing	_	_	_	_
8	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
9	AML1	AML1	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
10	)	)	PUNCT	-RRB-	_	_	_	_	_
11	and	and	CCONJ	CC	_	_	_	_	_
12	beta	beta	NOUN	NN	Number=Sing	_	_	_	_
13	subunits	subunit	NOUN	NNS	Number=Plur	_	_	_	_
14	on	on	ADP	IN	_	_	_	_	_
15	murine	murine	NOUN	NN	Number=Sing	_	_	_	_
16	leukemia	leukemia	NOUN	NN	Number=Sing	_	_	_	_
17	virus	virus	NOUN	NN	Number=Sing	_	_	_	_
18	enhancer	enhancer	NOUN	NN	Number=Sing	_	_	_	_
19	cores	core	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
20	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 2073
# text = Core binding factor (CBF), also known as polyomavirus enhancer-binding protein 2 and SL3 enhancer factor 1, is a mammalian transcription factor that binds to an element termed the core within the enhancers of the murine leukemia virus family of retroviruses.
1	Core	core	VERB	VB	Mood=Imp|VerbForm=Fin	_	_	_	_
2	binding	binding	VERB	VBG	VerbForm=Ger	_	_	_	_
3	factor	factor	NOUN	NN	Number=Sing	_	_	_	_
4	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
5	CBF	CBF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
6	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
7	,	,	PUNCT	,	_	_	_	_	_
8	also	also	ADV	RB	_	_	_	_	_
9	known	know	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
10	as	as	ADP	IN	_	_	_	_	_
11	polyomavirus	polyomavirus	NOUN	NN	Number=Sing	_	_	_	_
12	enhancer	enhancer	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
13	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
14	binding	binding	VERB	VBG	VerbForm=Ger	_	_	_	_
15	protein	protein	NOUN	NN	Number=Sing	_	_	_	_
16	2	2	NUM	CD	NumType=Card	_	_	_	_
17	and	and	CCONJ	CC	_	_	_	_	_
18	SL3	SL3	NUM	CD	NumType=Card	_	_	_	_
19	enhancer	enhancer	NOUN	NN	Number=Sing	_	_	_	_
20	factor	factor	NOUN	NN	Number=Sing	_	_	_	_
21	1	1	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
22	,	,	PUNCT	,	_	_	_	_	_
23	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
24	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
25	mammalian	mammalian	ADJ	JJ	Degree=Pos	_	_	_	_
26	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
27	factor	factor	NOUN	NN	Number=Sing	_	_	_	_
28	that	that	PRON	WDT	PronType=Rel	_	_	_	_
29	binds	bind	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
30	to	to	ADP	IN	_	_	_	_	_
31	an	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
32	element	element	NOUN	NN	Number=Sing	_	_	_	_
33	termed	term	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
34	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
35	core	core	NOUN	NN	Number=Sing	_	_	_	_
36	within	within	ADP	IN	_	_	_	_	_
37	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
38	enhancers	enhancer	NOUN	NNS	Number=Plur	_	_	_	_
39	of	of	ADP	IN	_	_	_	_	_
40	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
41	murine	murine	NOUN	NN	Number=Sing	_	_	_	_
42	leukemia	leukemia	NOUN	NN	Number=Sing	_	_	_	_
43	virus	virus	NOUN	NN	Number=Sing	_	_	_	_
44	family	family	NOUN	NN	Number=Sing	_	_	_	_
45	of	of	ADP	IN	_	_	_	_	_
46	retroviruses	retroviruse	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
47	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2074
# text = The core elements of the SL3 virus are important genetic determinants of the ability of this virus to induce T-cell lymphomas and the transcriptional activity of the viral long terminal repeat in T lymphocytes.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	core	core	NOUN	NN	Number=Sing	_	_	_	_
3	elements	element	NOUN	NNS	Number=Plur	_	_	_	_
4	of	of	ADP	IN	_	_	_	_	_
5	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
6	SL3	SL3	NOUN	NN	Number=Sing	_	_	_	_
7	virus	virus	NOUN	NN	Number=Sing	_	_	_	_
8	are	be	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
9	important	important	ADJ	JJ	Degree=Pos	_	_	_	_
10	genetic	genetic	ADJ	JJ	Degree=Pos	_	_	_	_
11	determinants	determinant	NOUN	NNS	Number=Plur	_	_	_	_
12	of	of	ADP	IN	_	_	_	_	_
13	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
14	ability	ability	NOUN	NN	Number=Sing	_	_	_	_
15	of	of	ADP	IN	_	_	_	_	_
16	this	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
17	virus	virus	NOUN	NN	Number=Sing	_	_	_	_
18	to	to	PART	TO	_	_	_	_	_
19	induce	induce	VERB	VB	VerbForm=Inf	_	_	_	_
20	T-	T-	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
21	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
22	lymphomas	lymphoma	NOUN	NNS	Number=Plur	_	_	_	_
23	and	and	CCONJ	CC	_	_	_	_	_
24	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
25	transcriptional	transcriptional	ADJ	JJ	Degree=Pos	_	_	_	_
26	activity	activity	NOUN	NN	Number=Sing	_	_	_	_
27	of	of	ADP	IN	_	_	_	_	_
28	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
29	viral	viral	ADJ	JJ	Degree=Pos	_	_	_	_
30	long	long	ADJ	JJ	Degree=Pos	_	_	_	_
31	terminal	terminal	NOUN	NN	Number=Sing	_	_	_	_
32	repeat	repeat	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
33	in	in	ADP	IN	_	_	_	_	_
34	T	t	PROPN	NNP	Number=Sing	_	_	_	_
35	lymphocytes	lymphocyte	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
36	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2075
# text = CBF consists of two subunits, a DNA binding subunit, CBF alpha, and a second subunit, CBF beta, that stimulates the DNA binding activity of CBF alpha.
1	CBF	Cbf	PROPN	NNP	Number=Sing	_	_	_	_
2	consists	consist	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
3	of	of	ADP	IN	_	_	_	_	_
4	two	two	NUM	CD	NumType=Card	_	_	_	_
5	subunits	subunit	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
6	,	,	PUNCT	,	_	_	_	_	_
7	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
8	DNA	dna	NOUN	NN	Number=Sing	_	_	_	_
9	binding	binding	VERB	VBG	VerbForm=Ger	_	_	_	_
10	subunit	subunit	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
11	,	,	PUNCT	,	_	_	_	_	_
12	CBF	CBF	PROPN	NNP	Number=Sing	_	_	_	_
13	alpha	alpha	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
14	,	,	PUNCT	,	_	_	_	_	_
15	and	and	CCONJ	CC	_	_	_	_	_
16	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
17	second	second	ADJ	JJ	Degree=Pos|NumType=Ord	_	_	_	_
18	subunit	subunit	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
19	,	,	PUNCT	,	_	_	_	_	_
20	CBF	CBF	PROPN	NNP	Number=Sing	_	_	_	_
21	beta	beta	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
22	,	,	PUNCT	,	_	_	_	_	_
23	that	that	PRON	DT	Number=Sing|PronType=Dem	_	_	_	_
24	stimulates	stimulate	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
25	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
26	DNA	dna	NOUN	NN	Number=Sing	_	_	_	_
27	binding	binde	VERB	VBG	VerbForm=Ger	_	_	_	_
28	activity	activity	NOUN	NN	Number=Sing	_	_	_	_
29	of	of	ADP	IN	_	_	_	_	_
30	CBF	CBF	PROPN	NNP	Number=Sing	_	_	_	_
31	alpha	alpha	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
32	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2076
# text = One of the genes that encodes a CBF alpha subunit is AML1, also called Cbf alpha
1	One	one	NUM	CD	NumType=Card	_	_	_	_
2	of	of	ADP	IN	_	_	_	_	_
3	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
4	genes	gene	NOUN	NNS	Number=Plur	_	_	_	_
5	that	that	PRON	WDT	PronType=Rel	_	_	_	_
6	encodes	encode	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
7	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
8	CBF	Cbf	PROPN	NNP	Number=Sing	_	_	_	_
9	alpha	alpha	NOUN	NN	Number=Sing	_	_	_	_
10	subunit	subunit	NOUN	NN	Number=Sing	_	_	_	_
11	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
12	AML1	AML1	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
13	,	,	PUNCT	,	_	_	_	_	_
14	also	also	ADV	RB	_	_	_	_	_
15	called	call	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
16	Cbf	Cbf	PROPN	NNP	Number=Sing	_	_	_	_
17	alpha	alpha	NOUN	NN	Number=Sing	_	_	_	_

# sent_id = 2077
# text = 2.
1	2	2	X	LS	_	_	_	_	SpaceAfter=No
2	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2078
# text = This locus is rearranged by chromosomal translocations in human myeloproliferative disorders and leukemias.
1	This	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
2	locus	locus	NOUN	NN	Number=Sing	_	_	_	_
3	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
4	rearranged	rearrange	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
5	by	by	ADP	IN	_	_	_	_	_
6	chromosomal	chromosomal	ADJ	JJ	Degree=Pos	_	_	_	_
7	translocations	translocation	NOUN	NNS	Number=Plur	_	_	_	_
8	in	in	ADP	IN	_	_	_	_	_
9	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
10	myeloproliferative	myeloproliferative	ADJ	JJ	Degree=Pos	_	_	_	_
11	disorders	disorder	NOUN	NNS	Number=Plur	_	_	_	_
12	and	and	CCONJ	CC	_	_	_	_	_
13	leukemias	leukemia	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
14	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2079
# text = An exogenously expressed Cbf alpha 2-encoded subunit (CBF alpha 2-451) stimulated transcription from the SL3 enhancer in P19 and HeLa cells.
1	An	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
2	exogenously	exogenously	ADV	RB	_	_	_	_	_
3	expressed	express	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
4	Cbf	Cbf	PROPN	NNP	Number=Sing	_	_	_	_
5	alpha	alpha	NOUN	NN	Number=Sing	_	_	_	_
6	2	2	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
7	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
8	encoded	encod	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
9	subunit	subunit	NOUN	NN	Number=Sing	_	_	_	_
10	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
11	CBF	CBF	NOUN	NN	Number=Sing	_	_	_	_
12	alpha	alpha	NOUN	NN	Number=Sing	_	_	_	_
13	2-	2-	SYM	SYM	_	_	_	_	SpaceAfter=No
14	451	451	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
15	)	)	PUNCT	-RRB-	_	_	_	_	_
16	stimulated	stimulate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
17	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
18	from	from	ADP	IN	_	_	_	_	_
19	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
20	SL3	SL3	NOUN	NN	Number=Sing	_	_	_	_
21	enhancer	enhancer	NOUN	NN	Number=Sing	_	_	_	_
22	in	in	ADP	IN	_	_	_	_	_
23	P19	P19	PROPN	NNP	Number=Sing	_	_	_	_
24	and	and	CCONJ	CC	_	_	_	_	_
25	HeLa	HeLa	PROPN	NNP	Number=Sing	_	_	_	_
26	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
27	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2080
# text = Activity was mediated through the core elements.
1	Activity	activity	NOUN	NN	Number=Sing	_	_	_	_
2	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
3	mediated	mediate	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
4	through	through	ADP	IN	_	_	_	_	_
5	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
6	core	core	NOUN	NN	Number=Sing	_	_	_	_
7	elements	element	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
8	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2081
# text = Three different isoforms of CBF beta were also tested for transcriptional activity on the SL3 enhancer.
1	Three	Three	NUM	CD	NumType=Card	_	_	_	_
2	different	different	ADJ	JJ	Degree=Pos	_	_	_	_
3	isoforms	isoform	NOUN	NNS	Number=Plur	_	_	_	_
4	of	of	ADP	IN	_	_	_	_	_
5	CBF	CBF	PROPN	NNP	Number=Sing	_	_	_	_
6	beta	beta	NOUN	NN	Number=Sing	_	_	_	_
7	were	be	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
8	also	also	ADV	RB	_	_	_	_	_
9	tested	test	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
10	for	for	ADP	IN	_	_	_	_	_
11	transcriptional	transcriptional	ADJ	JJ	Degree=Pos	_	_	_	_
12	activity	activity	NOUN	NN	Number=Sing	_	_	_	_
13	on	on	ADP	IN	_	_	_	_	_
14	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
15	SL3	SL3	NUM	CD	NumType=Card	_	_	_	_
16	enhancer	enhancer	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
17	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2082
# text = The longest form, CBF beta-187, increased the transcriptional stimulation by CBF alpha 2-451 twofold in HeLa cells, although it had no effect in P19 cells.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	longest	longest	ADJ	JJS	Degree=Sup	_	_	_	_
3	form	form	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
4	,	,	PUNCT	,	_	_	_	_	_
5	CBF	CBF	PROPN	NNP	Number=Sing	_	_	_	_
6	beta	beta	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
7	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
8	187	187	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
9	,	,	PUNCT	,	_	_	_	_	_
10	increased	increase	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
11	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
12	transcriptional	transcriptional	ADJ	JJ	Degree=Pos	_	_	_	_
13	stimulation	stimulation	NOUN	NN	Number=Sing	_	_	_	_
14	by	by	ADP	IN	_	_	_	_	_
15	CBF	CBF	PROPN	NNP	Number=Sing	_	_	_	_
16	alpha	alpha	ADV	RB	_	_	_	_	_
17	2-	2-	SYM	SYM	_	_	_	_	SpaceAfter=No
18	451	451	NUM	CD	NumType=Card	_	_	_	_
19	twofold	twofold	NOUN	NN	Number=Sing	_	_	_	_
20	in	in	ADP	IN	_	_	_	_	_
21	HeLa	HeLa	PROPN	NNP	Number=Sing	_	_	_	_
22	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
23	,	,	PUNCT	,	_	_	_	_	_
24	although	although	SCONJ	IN	_	_	_	_	_
25	it	it	PRON	PRP	Case=Nom|Gender=Neut|Number=Sing|Person=3|PronType=Prs	_	_	_	_
26	had	have	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
27	no	no	DET	DT	_	_	_	_	_
28	effect	effect	NOUN	NN	Number=Sing	_	_	_	_
29	in	in	ADP	IN	_	_	_	_	_
30	P19	P19	NUM	CD	NumType=Card	_	_	_	_
31	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
32	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2083
# text = Transcriptional activation by CBF beta required binding to the CBF alpha subunit, as a form of CBF beta that lacked binding ability, CBF beta-148, failed to increase activity.
1	Transcriptional	Transcriptional	ADJ	JJ	Degree=Pos	_	_	_	_
2	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
3	by	by	ADP	IN	_	_	_	_	_
4	CBF	CBF	PROPN	NNP	Number=Sing	_	_	_	_
5	beta	beta	PROPN	NNP	Number=Sing	_	_	_	_
6	required	require	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
7	binding	bind	VERB	VBG	VerbForm=Ger	_	_	_	_
8	to	to	ADP	IN	_	_	_	_	_
9	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
10	CBF	CBF	PROPN	NNP	Number=Sing	_	_	_	_
11	alpha	alpha	NOUN	NN	Number=Sing	_	_	_	_
12	subunit	subunit	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
13	,	,	PUNCT	,	_	_	_	_	_
14	as	as	ADP	IN	_	_	_	_	_
15	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
16	form	form	NOUN	NN	Number=Sing	_	_	_	_
17	of	of	ADP	IN	_	_	_	_	_
18	CBF	CBF	PROPN	NNP	Number=Sing	_	_	_	_
19	beta	beta	NOUN	NN	Number=Sing	_	_	_	_
20	that	that	PRON	WDT	PronType=Rel	_	_	_	_
21	lacked	lack	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
22	binding	bind	VERB	VBG	VerbForm=Ger	_	_	_	_
23	ability	ability	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
24	,	,	PUNCT	,	_	_	_	_	_
25	CBF	CBF	PROPN	NNP	Number=Sing	_	_	_	_
26	beta	beta	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
27	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
28	148	148	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
29	,	,	PUNCT	,	_	_	_	_	_
30	failed	fail	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
31	to	to	PART	TO	_	_	_	_	_
32	increase	increase	VERB	VB	VerbForm=Inf	_	_	_	_
33	activity	activity	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
34	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2084
# text = These results indicated that at least in certain cell types, the maximum activity of CBF required both subunits.
1	These	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
2	results	result	NOUN	NNS	Number=Plur	_	_	_	_
3	indicated	indicate	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
4	that	that	SCONJ	IN	_	_	_	_	_
5	at	at	ADV	RB	_	_	_	_	_
6	least	least	ADV	RBS	Degree=Sup	_	_	_	_
7	in	in	ADP	IN	_	_	_	_	_
8	certain	certain	ADJ	JJ	Degree=Pos	_	_	_	_
9	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
10	types	type	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
11	,	,	PUNCT	,	_	_	_	_	_
12	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
13	maximum	maximum	ADJ	JJ	Degree=Pos	_	_	_	_
14	activity	activity	NOUN	NN	Number=Sing	_	_	_	_
15	of	of	ADP	IN	_	_	_	_	_
16	CBF	CBF	PROPN	NNP	Number=Sing	_	_	_	_
17	required	require	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
18	both	both	DET	DT	_	_	_	_	_
19	subunits	subunit	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
20	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2085
# text = They also provided support for the hypothesis that CBF is a factor in T lymphocytes that is responsible for recognition of the SL3 cores.
1	They	they	PRON	PRP	Case=Nom|Number=Plur|Person=3|PronType=Prs	_	_	_	_
2	also	also	ADV	RB	_	_	_	_	_
3	provided	provide	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
4	support	support	NOUN	NN	Number=Sing	_	_	_	_
5	for	for	ADP	IN	_	_	_	_	_
6	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
7	hypothesis	hypothesis	NOUN	NN	Number=Sing	_	_	_	_
8	that	that	PRON	WDT	PronType=Rel	_	_	_	_
9	CBF	CBF	PROPN	NNP	Number=Sing	_	_	_	_
10	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
11	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
12	factor	factor	NOUN	NN	Number=Sing	_	_	_	_
13	in	in	ADP	IN	_	_	_	_	_
14	T	t	PROPN	NNP	Number=Sing	_	_	_	_
15	lymphocytes	lymphocyte	NOUN	NNS	Number=Plur	_	_	_	_
16	that	that	PRON	WDT	PronType=Rel	_	_	_	_
17	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
18	responsible	responsible	ADJ	JJ	Degree=Pos	_	_	_	_
19	for	for	ADP	IN	_	_	_	_	_
20	recognition	recognition	NOUN	NN	Number=Sing	_	_	_	_
21	of	of	ADP	IN	_	_	_	_	_
22	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
23	SL3	SL3	NOUN	NN	Number=Sing	_	_	_	_
24	cores	core	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
25	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2086
# text = We also examined whether CBF could distinguish a 1-bp difference between the enhancer core of SL3 and the core of the nonleukemogenic virus, Akv.
1	We	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
2	also	also	ADV	RB	_	_	_	_	_
3	examined	examin	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
4	whether	whether	SCONJ	IN	_	_	_	_	_
5	CBF	CBF	PROPN	NNP	Number=Sing	_	_	_	_
6	could	could	AUX	MD	VerbForm=Fin	_	_	_	_
7	distinguish	distinguish	VERB	VB	VerbForm=Inf	_	_	_	_
8	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
9	1	1	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
10	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
11	bp	bp	NOUN	NN	Number=Sing	_	_	_	_
12	difference	difference	NOUN	NN	Number=Sing	_	_	_	_
13	between	between	ADP	IN	_	_	_	_	_
14	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
15	enhancer	enhancer	NOUN	NN	Number=Sing	_	_	_	_
16	core	core	NOUN	NN	Number=Sing	_	_	_	_
17	of	of	ADP	IN	_	_	_	_	_
18	SL3	SL3	NOUN	NN	Number=Sing	_	_	_	_
19	and	and	CCONJ	CC	_	_	_	_	_
20	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
21	core	core	NOUN	NN	Number=Sing	_	_	_	_
22	of	of	ADP	IN	_	_	_	_	_
23	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
24	nonleukemogenic	nonleukemogenic	ADJ	JJ	Degree=Pos	_	_	_	_
25	virus	virus	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
26	,	,	PUNCT	,	_	_	_	_	_
27	Akv	Akv	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
28	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2087
# text = This difference strongly affects transcription in T cells and leukemogenicity of SL3.
1	This	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
2	difference	difference	NOUN	NN	Number=Sing	_	_	_	_
3	strongly	strongly	ADV	RB	_	_	_	_	_
4	affects	affect	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
5	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
6	in	in	ADP	IN	_	_	_	_	_
7	T	t	PROPN	NNP	Number=Sing	_	_	_	_
8	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
9	and	and	CCONJ	CC	_	_	_	_	_
10	leukemogenicity	leukemogenicity	NOUN	NN	Number=Sing	_	_	_	_
11	of	of	ADP	IN	_	_	_	_	_
12	SL3	SL3	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
13	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2088
# text = However, no combination of CBF alpha and CBF beta subunits that we tested was able to distinguish the 1-bp difference in transcription assays.
1	However	however	ADV	RB	_	_	_	_	SpaceAfter=No
2	,	,	PUNCT	,	_	_	_	_	_
3	no	no	DET	DT	_	_	_	_	_
4	combination	combination	NOUN	NN	Number=Sing	_	_	_	_
5	of	of	ADP	IN	_	_	_	_	_
6	CBF	CBF	PROPN	NNP	Number=Sing	_	_	_	_
7	alpha	alpha	PROPN	NNP	Number=Sing	_	_	_	_
8	and	and	CCONJ	CC	_	_	_	_	_
9	CBF	CBF	PROPN	NNP	Number=Sing	_	_	_	_
10	beta	beta	NOUN	NN	Number=Sing	_	_	_	_
11	subunits	subunit	NOUN	NNS	Number=Plur	_	_	_	_
12	that	that	PRON	WDT	PronType=Rel	_	_	_	_
13	we	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
14	tested	test	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
15	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
16	able	able	ADJ	JJ	Degree=Pos	_	_	_	_
17	to	to	PART	TO	_	_	_	_	_
18	distinguish	distinguish	VERB	VB	VerbForm=Inf	_	_	_	_
19	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
20	1	1	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
21	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
22	bp	bp	NOUN	NN	Number=Sing	_	_	_	_
23	difference	difference	NOUN	NN	Number=Sing	_	_	_	_
24	in	in	ADP	IN	_	_	_	_	_
25	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
26	assays	assay	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
27	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2089
# text = Thus, a complete understanding of how T cells recognize the SL3 core remains to be elucidated.
1	Thus	thus	ADV	RB	_	_	_	_	SpaceAfter=No
2	,	,	PUNCT	,	_	_	_	_	_
3	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
4	complete	complete	ADJ	JJ	Degree=Pos	_	_	_	_
5	understanding	understanding	NOUN	NN	Number=Sing	_	_	_	_
6	of	of	SCONJ	IN	_	_	_	_	_
7	how	how	ADV	WRB	PronType=Int	_	_	_	_
8	T	t	PROPN	NNP	Number=Sing	_	_	_	_
9	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
10	recognize	recognize	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
11	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
12	SL3	SL3	NOUN	NN	Number=Sing	_	_	_	_
13	core	core	NOUN	NN	Number=Sing	_	_	_	_
14	remains	remain	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
15	to	to	PART	TO	_	_	_	_	_
16	be	be	AUX	VB	VerbForm=Inf	_	_	_	_
17	elucidated	elucidate	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	SpaceAfter=No
18	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 2090
# text = Document 003003129 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	003003129	003003129	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 2091
# text = Selective DNA-binding activity of interleukin-10-stimulated STAT molecules in human monocytes.
1	Selective	selective	ADJ	JJ	Degree=Pos	_	_	_	_
2	DNA	dna	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
3	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
4	binding	bind	VERB	VBG	VerbForm=Ger	_	_	_	_
5	activity	activity	NOUN	NN	Number=Sing	_	_	_	_
6	of	of	ADP	IN	_	_	_	_	_
7	interleukin	interleukin	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
8	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
9	10	10	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
10	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
11	stimulated	stimulate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
12	STAT	Stat	NOUN	NN	Number=Sing	_	_	_	_
13	molecules	molecule	NOUN	NNS	Number=Plur	_	_	_	_
14	in	in	ADP	IN	_	_	_	_	_
15	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
16	monocytes	monocyte	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
17	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 2092
# text = It has been demonstrated that interferon-gamma (IFN-gamma) and interleukin-10 (IL-10) have various reverse effects on macrophages; however, the molecular mechanism of this difference has not been fully understood.
1	It	it	PRON	PRP	Case=Nom|Gender=Neut|Number=Sing|Person=3|PronType=Prs	_	_	_	_
2	has	have	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
3	been	be	AUX	VBN	Tense=Past|VerbForm=Part	_	_	_	_
4	demonstrated	demonstrate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
5	that	that	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
6	interferon	interferon	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
7	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
8	gamma	gamma	NOUN	NN	Number=Sing	_	_	_	_
9	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
10	IFN	Ifn	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
11	-gamma	-gamma	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
12	)	)	PUNCT	-RRB-	_	_	_	_	_
13	and	and	CCONJ	CC	_	_	_	_	_
14	interleukin	interleukin	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
15	-10	-10	NUM	CD	NumType=Card	_	_	_	_
16	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
17	IL	Il	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
18	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
19	10	10	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
20	)	)	PUNCT	-RRB-	_	_	_	_	_
21	have	have	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
22	various	various	ADJ	JJ	Degree=Pos	_	_	_	_
23	reverse	reverse	NOUN	NN	Number=Sing	_	_	_	_
24	effects	effect	NOUN	NNS	Number=Plur	_	_	_	_
25	on	on	ADP	IN	_	_	_	_	_
26	macrophages	macrophage	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
27	;	;	PUNCT	,	_	_	_	_	_
28	however	however	ADV	RB	_	_	_	_	SpaceAfter=No
29	,	,	PUNCT	,	_	_	_	_	_
30	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
31	molecular	molecular	ADJ	JJ	Degree=Pos	_	_	_	_
32	mechanism	mechanism	NOUN	NN	Number=Sing	_	_	_	_
33	of	of	ADP	IN	_	_	_	_	_
34	this	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
35	difference	difference	NOUN	NN	Number=Sing	_	_	_	_
36	has	have	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
37	not	not	PART	RB	_	_	_	_	_
38	been	be	AUX	VBN	Tense=Past|VerbForm=Part	_	_	_	_
39	fully	fully	ADV	RB	_	_	_	_	_
40	understood	understand	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
41	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2093
# text = In this study, we analyzed the binding activity of IL-10- and IFN-gamma-activated
1	In	in	ADP	IN	_	_	_	_	_
2	this	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
3	study	study	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
4	,	,	PUNCT	,	_	_	_	_	_
5	we	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
6	analyzed	analyze	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
7	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
8	binding	bind	VERB	VBG	VerbForm=Ger	_	_	_	_
9	activity	activity	NOUN	NN	Number=Sing	_	_	_	_
10	of	of	ADP	IN	_	_	_	_	_
11	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
12	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
13	10	10	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
14	-	-	PUNCT	HYPH	_	_	_	_	_
15	and	and	CCONJ	CC	_	_	_	_	_
16	IFN-	Ifn-	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
17	gamma	gamma	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
18	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
19	activated	activate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_

# sent_id = 2094
# text = STAT molecules to two kinds of GAS-motif sequences.
1	STAT	Stat	ADJ	JJ	Degree=Pos	_	_	_	_
2	molecules	molecule	NOUN	NNS	Number=Plur	_	_	_	_
3	to	to	ADP	IN	_	_	_	_	_
4	two	two	NUM	CD	NumType=Card	_	_	_	_
5	kinds	kind	NOUN	NNS	Number=Plur	_	_	_	_
6	of	of	ADP	IN	_	_	_	_	_
7	GAS	gas	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
8	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
9	motif	motif	NOUN	NN	Number=Sing	_	_	_	_
10	sequences	sequence	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
11	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2095
# text = IL-10-activated STAT1 could bind to the GAS-motif sequence in the promoter region of the Fcgamma receptor, but not to that in the promoter region of the COX-2 gene, whereas IFN-gamma-activated STAT1 and STAT5 could bind to both sequences.
1	IL	Il	INTJ	UH	_	_	_	_	SpaceAfter=No
2	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
3	10	10	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
4	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
5	activated	activated	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
6	STAT1	stat1	PROPN	NNP	Number=Sing	_	_	_	_
7	could	could	AUX	MD	VerbForm=Fin	_	_	_	_
8	bind	bind	VERB	VB	VerbForm=Inf	_	_	_	_
9	to	to	ADP	IN	_	_	_	_	_
10	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
11	GAS	gas	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
12	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
13	motif	motif	NOUN	NN	Number=Sing	_	_	_	_
14	sequence	sequence	NOUN	NN	Number=Sing	_	_	_	_
15	in	in	ADP	IN	_	_	_	_	_
16	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
17	promoter	promoter	NOUN	NN	Number=Sing	_	_	_	_
18	region	region	NOUN	NN	Number=Sing	_	_	_	_
19	of	of	ADP	IN	_	_	_	_	_
20	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
21	Fcgamma	Fcgamma	PROPN	NNP	Number=Sing	_	_	_	_
22	receptor	receptor	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
23	,	,	PUNCT	,	_	_	_	_	_
24	but	but	CCONJ	CC	_	_	_	_	_
25	not	not	ADV	RB	_	_	_	_	_
26	to	to	ADP	IN	_	_	_	_	_
27	that	that	PRON	DT	Number=Sing|PronType=Dem	_	_	_	_
28	in	in	ADP	IN	_	_	_	_	_
29	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
30	promoter	promoter	NOUN	NN	Number=Sing	_	_	_	_
31	region	region	NOUN	NN	Number=Sing	_	_	_	_
32	of	of	ADP	IN	_	_	_	_	_
33	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
34	COX	cox	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
35	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
36	2	2	NUM	CD	NumType=Card	_	_	_	_
37	gene	gene	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
38	,	,	PUNCT	,	_	_	_	_	_
39	whereas	whereas	SCONJ	IN	_	_	_	_	_
40	IFN-	IFN-	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
41	gamma	gamma	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
42	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
43	activated	activated	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
44	STAT1	stat1	PROPN	NNP	Number=Sing	_	_	_	_
45	and	and	CCONJ	CC	_	_	_	_	_
46	STAT5	stat5	PROPN	NNP	Number=Sing	_	_	_	_
47	could	could	AUX	MD	VerbForm=Fin	_	_	_	_
48	bind	bind	VERB	VB	VerbForm=Inf	_	_	_	_
49	to	to	ADP	IN	_	_	_	_	_
50	both	both	DET	DT	_	_	_	_	_
51	sequences	sequence	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
52	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2096
# text = IL-10 inhibited IFN-gamma-induced STAT activation without newly synthesized protein.
1	IL	Il	INTJ	UH	_	_	_	_	SpaceAfter=No
2	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
3	10	10	NUM	CD	NumType=Card	_	_	_	_
4	inhibited	inhibit	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
5	IFN-	IFN-	SYM	SYM	_	_	_	_	SpaceAfter=No
6	gamma	gamma	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
7	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
8	induced	induce	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
9	STAT	Stat	NOUN	NN	Number=Sing	_	_	_	_
10	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
11	without	without	ADP	IN	_	_	_	_	_
12	newly	newly	ADV	RB	_	_	_	_	_
13	synthesized	synthesize	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
14	protein	protein	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
15	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2097
# text = We further demonstrated that aspirin, but not dexamethasone, suppressed IFN-gamma-induced STAT activation.
1	We	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
2	further	further	ADV	RB	_	_	_	_	_
3	demonstrated	demonstrate	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
4	that	that	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
5	aspirin	aspirin	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
6	,	,	PUNCT	,	_	_	_	_	_
7	but	but	CCONJ	CC	_	_	_	_	_
8	not	not	ADV	RB	_	_	_	_	_
9	dexamethasone	dexamethasone	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	SpaceAfter=No
10	,	,	PUNCT	,	_	_	_	_	_
11	suppressed	suppress	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
12	IFN-	IFN-	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
13	gamma	gamma	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
14	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
15	induced	induce	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
16	STAT	Stat	NOUN	NN	Number=Sing	_	_	_	_
17	activation	activation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
18	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2098
# text = Taken together, these results suggest that IL-10-activated STAT1 has a specificity in binding to the GAS-motif sequences, whereas IFN-gamma-activated STAT1 and STAT5 have a broader spectrum in binding to the GAS-motif sequences.
1	Taken	take	PROPN	NNP	Number=Sing	_	_	_	_
2	together	together	ADV	RB	_	_	_	_	SpaceAfter=No
3	,	,	PUNCT	,	_	_	_	_	_
4	these	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
5	results	result	NOUN	NNS	Number=Plur	_	_	_	_
6	suggest	suggest	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
7	that	that	SCONJ	IN	_	_	_	_	_
8	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
9	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
10	10	10	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
11	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
12	activated	activated	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
13	STAT1	stat1	NOUN	NN	Number=Sing	_	_	_	_
14	has	have	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
15	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
16	specificity	specificity	NOUN	NN	Number=Sing	_	_	_	_
17	in	in	SCONJ	IN	_	_	_	_	_
18	binding	binding	VERB	VBG	VerbForm=Ger	_	_	_	_
19	to	to	ADP	IN	_	_	_	_	_
20	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
21	GAS	gas	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
22	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
23	motif	motif	NOUN	NN	Number=Sing	_	_	_	_
24	sequences	sequence	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
25	,	,	PUNCT	,	_	_	_	_	_
26	whereas	wherea	SCONJ	IN	_	_	_	_	_
27	IFN-	IFN-	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
28	gamma	gamma	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
29	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
30	activated	activated	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
31	STAT1	stat1	PROPN	NNP	Number=Sing	_	_	_	_
32	and	and	CCONJ	CC	_	_	_	_	_
33	STAT5	stat5	PROPN	NNP	Number=Sing	_	_	_	_
34	have	have	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
35	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
36	broader	broader	ADJ	JJR	Degree=Cmp	_	_	_	_
37	spectrum	spectrum	NOUN	NN	Number=Sing	_	_	_	_
38	in	in	SCONJ	IN	_	_	_	_	_
39	binding	bind	VERB	VBG	VerbForm=Ger	_	_	_	_
40	to	to	ADP	IN	_	_	_	_	_
41	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
42	GAS	gas	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
43	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
44	motif	motif	NOUN	NN	Number=Sing	_	_	_	_
45	sequences	sequence	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
46	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2099
# text = This may explain the difference between IL-10 and IFN-gamma in biological activity, and the inhibitory effect of IL-10 on IFN-gamma activities.
1	This	this	PRON	DT	Number=Sing|PronType=Dem	_	_	_	_
2	may	may	AUX	MD	VerbForm=Fin	_	_	_	_
3	explain	explain	VERB	VB	VerbForm=Inf	_	_	_	_
4	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
5	difference	difference	NOUN	NN	Number=Sing	_	_	_	_
6	between	between	ADP	IN	_	_	_	_	_
7	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
8	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
9	10	10	NUM	CD	NumType=Card	_	_	_	_
10	and	and	CCONJ	CC	_	_	_	_	_
11	IFN	Ifn	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
12	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
13	gamma	gamma	NOUN	NN	Number=Sing	_	_	_	_
14	in	in	ADP	IN	_	_	_	_	_
15	biological	biological	ADJ	JJ	Degree=Pos	_	_	_	_
16	activity	activity	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
17	,	,	PUNCT	,	_	_	_	_	_
18	and	and	CCONJ	CC	_	_	_	_	_
19	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
20	inhibitory	inhibitory	ADJ	JJ	Degree=Pos	_	_	_	_
21	effect	effect	NOUN	NN	Number=Sing	_	_	_	_
22	of	of	ADP	IN	_	_	_	_	_
23	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
24	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
25	10	10	NUM	CD	NumType=Card	_	_	_	_
26	on	on	ADP	IN	_	_	_	_	_
27	IFN	Ifn	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
28	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
29	gamma	gamma	NOUN	NN	Number=Sing	_	_	_	_
30	activities	activity	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
31	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 2100
# text = Document 003003130 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	003003130	003003130	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 2101
# text = Protein kinase inhibitor H-7 blocks accumulation of unspliced mRNA of human T-cell leukemia virus type I (HTLV-I).
1	Protein	protein	NOUN	NN	Number=Sing	_	_	_	_
2	kinase	kinase	NOUN	NN	Number=Sing	_	_	_	_
3	inhibitor	inhibitor	NOUN	NN	Number=Sing	_	_	_	_
4	H	h	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
5	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
6	7	7	NUM	CD	NumType=Card	_	_	_	_
7	blocks	block	NOUN	NNS	Number=Plur	_	_	_	_
8	accumulation	accumulation	NOUN	NN	Number=Sing	_	_	_	_
9	of	of	ADP	IN	_	_	_	_	_
10	unspliced	unspliced	ADJ	JJ	Degree=Pos	_	_	_	_
11	mRNA	mRNa	NOUN	NN	Number=Sing	_	_	_	_
12	of	of	ADP	IN	_	_	_	_	_
13	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
14	T-	t-	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
15	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
16	leukemia	leukemia	NOUN	NN	Number=Sing	_	_	_	_
17	virus	virus	NOUN	NN	Number=Sing	_	_	_	_
18	type	type	NOUN	NN	Number=Sing	_	_	_	_
19	I	I	PRON	PRP	Case=Nom|Number=Sing|Person=1|PronType=Prs	_	_	_	_
20	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
21	HTLV	HTLV	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
22	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
23	I	I	PRON	PRP	Case=Nom|Number=Sing|Person=1|PronType=Prs	_	_	_	SpaceAfter=No
24	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
25	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 2102
# text = Rex, the post-transcriptional regulator of human T-cell leukemia virus type I (HTLV-I), is known to induce accumulation of the unspliced viral gag-pol mRNA.
1	Rex	Rex	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
2	,	,	PUNCT	,	_	_	_	_	_
3	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
4	post	post	X	AFX	_	_	_	_	SpaceAfter=No
5	-transcriptional	-transcriptional	ADJ	JJ	Degree=Pos	_	_	_	_
6	regulator	regulator	NOUN	NN	Number=Sing	_	_	_	_
7	of	of	ADP	IN	_	_	_	_	_
8	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
9	T-	t-	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
10	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
11	leukemia	leukemia	NOUN	NN	Number=Sing	_	_	_	_
12	virus	virus	NOUN	NN	Number=Sing	_	_	_	_
13	type	type	NOUN	NN	Number=Sing	_	_	_	_
14	I	I	PRON	PRP	Case=Nom|Number=Sing|Person=1|PronType=Prs	_	_	_	_
15	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
16	HTLV	HTLV	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
17	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
18	I	I	PRON	PRP	Case=Nom|Number=Sing|Person=1|PronType=Prs	_	_	_	SpaceAfter=No
19	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
20	,	,	PUNCT	,	_	_	_	_	_
21	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
22	known	know	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
23	to	to	PART	TO	_	_	_	_	_
24	induce	induce	VERB	VB	VerbForm=Inf	_	_	_	_
25	accumulation	accumulation	NOUN	NN	Number=Sing	_	_	_	_
26	of	of	ADP	IN	_	_	_	_	_
27	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
28	unspliced	unspliced	ADJ	JJ	Degree=Pos	_	_	_	_
29	viral	viral	ADJ	JJ	Degree=Pos	_	_	_	_
30	gag	gag	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
31	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
32	pol	pol	NOUN	NN	Number=Sing	_	_	_	_
33	mRNA	mRNa	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
34	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2103
# text = Rex is a phosphoprotein found in the cell nucleolus, whose function may be regulated by its localization and phosphorylation.
1	Rex	Rex	NOUN	NN	Number=Sing	_	_	_	_
2	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
3	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
4	phosphoprotein	phosphoprotein	NOUN	NN	Number=Sing	_	_	_	_
5	found	find	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
6	in	in	ADP	IN	_	_	_	_	_
7	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
8	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
9	nucleolus	nucleolus	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
10	,	,	PUNCT	,	_	_	_	_	_
11	whose	whose	PRON	WP$	Poss=Yes|PronType=Int	_	_	_	_
12	function	function	NOUN	NN	Number=Sing	_	_	_	_
13	may	may	AUX	MD	VerbForm=Fin	_	_	_	_
14	be	be	AUX	VB	VerbForm=Inf	_	_	_	_
15	regulated	regulate	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
16	by	by	ADP	IN	_	_	_	_	_
17	its	its	PRON	PRP$	Gender=Neut|Number=Sing|Person=3|Poss=Yes|PronType=Prs	_	_	_	_
18	localization	localization	NOUN	NN	Number=Sing	_	_	_	_
19	and	and	CCONJ	CC	_	_	_	_	_
20	phosphorylation	phosphorylation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
21	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2104
# text = We have examined the role of phosphorylation on Rex function by using a protein kinase inhibitor, H-7 [1-(5-isoquinolinyl-sulfonyl)-2-methylpiperazine].
1	We	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
2	have	have	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
3	examined	examine	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
4	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
5	role	role	NOUN	NN	Number=Sing	_	_	_	_
6	of	of	ADP	IN	_	_	_	_	_
7	phosphorylation	phosphorylation	NOUN	NN	Number=Sing	_	_	_	_
8	on	on	ADP	IN	_	_	_	_	_
9	Rex	Rex	NOUN	NN	Number=Sing	_	_	_	_
10	function	function	NOUN	NN	Number=Sing	_	_	_	_
11	by	by	SCONJ	IN	_	_	_	_	_
12	using	use	VERB	VBG	VerbForm=Ger	_	_	_	_
13	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
14	protein	protein	NOUN	NN	Number=Sing	_	_	_	_
15	kinase	kinase	NOUN	NN	Number=Sing	_	_	_	_
16	inhibitor	inhibitor	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
17	,	,	PUNCT	,	_	_	_	_	_
18	H	h	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
19	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
20	7	7	NUM	CD	NumType=Card	_	_	_	_
21	[	[	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
22	1-(	1-(	SYM	NFP	_	_	_	_	SpaceAfter=No
23	5-isoquinolinyl-sulfonyl	5-isoquinolinyl-sulfonyl	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
24	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
25	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
26	2	2	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
27	-methylpiperazine	-methylpiperazine	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
28	]	]	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
29	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2105
# text = Treatment of an HTLV-I infected human T-cell line with H-7 blocked specifically accumulation of the unspliced gag-pol mRNA, resulting in the decreased Gag protein synthesis that corresponds with the decreased in vivo phosphorylation of Rex.
1	Treatment	treatment	NOUN	NN	Number=Sing	_	_	_	_
2	of	of	ADP	IN	_	_	_	_	_
3	an	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
4	HTLV	HTLV	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
5	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
6	I	I	PRON	PRP	Case=Nom|Number=Sing|Person=1|PronType=Prs	_	_	_	_
7	infected	infect	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
8	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
9	T-	t-	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
10	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
11	line	line	NOUN	NN	Number=Sing	_	_	_	_
12	with	with	ADP	IN	_	_	_	_	_
13	H	H	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
14	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
15	7	7	NUM	CD	NumType=Card	_	_	_	_
16	blocked	block	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
17	specifically	specifically	ADV	RB	_	_	_	_	_
18	accumulation	accumulation	NOUN	NN	Number=Sing	_	_	_	_
19	of	of	ADP	IN	_	_	_	_	_
20	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
21	unspliced	unspliced	ADJ	JJ	Degree=Pos	_	_	_	_
22	gag	gag	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
23	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
24	pol	pol	NOUN	NN	Number=Sing	_	_	_	_
25	mRNA	mRNa	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
26	,	,	PUNCT	,	_	_	_	_	_
27	resulting	result	VERB	VBG	VerbForm=Ger	_	_	_	_
28	in	in	ADP	IN	_	_	_	_	_
29	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
30	decreased	decreased	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
31	Gag	Gag	NOUN	NN	Number=Sing	_	_	_	_
32	protein	protein	NOUN	NN	Number=Sing	_	_	_	_
33	synthesis	synthesis	NOUN	NN	Number=Sing	_	_	_	_
34	that	that	PRON	WDT	PronType=Rel	_	_	_	_
35	corresponds	correspond	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
36	with	with	ADP	IN	_	_	_	_	_
37	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
38	decreased	decrease	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
39	in	in	ADP	IN	_	_	_	_	_
40	vivo	vivo	NOUN	NN	Number=Sing	_	_	_	_
41	phosphorylation	phosphorylation	NOUN	NN	Number=Sing	_	_	_	_
42	of	of	ADP	IN	_	_	_	_	_
43	Rex	Rex	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
44	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2106
# text = In contrast, other viral and cellular products have not been influenced by the level of H-7 used.
1	In	in	ADP	IN	_	_	_	_	_
2	contrast	contrast	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
3	,	,	PUNCT	,	_	_	_	_	_
4	other	other	ADJ	JJ	Degree=Pos	_	_	_	_
5	viral	viral	ADJ	JJ	Degree=Pos	_	_	_	_
6	and	and	CCONJ	CC	_	_	_	_	_
7	cellular	cellular	ADJ	JJ	Degree=Pos	_	_	_	_
8	products	product	NOUN	NNS	Number=Plur	_	_	_	_
9	have	have	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
10	not	not	PART	RB	_	_	_	_	_
11	been	be	AUX	VBN	Tense=Past|VerbForm=Part	_	_	_	_
12	influenced	influence	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
13	by	by	ADP	IN	_	_	_	_	_
14	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
15	level	level	NOUN	NN	Number=Sing	_	_	_	_
16	of	of	ADP	IN	_	_	_	_	_
17	H	H	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
18	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
19	7	7	NUM	CD	NumType=Card	_	_	_	_
20	used	use	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	SpaceAfter=No
21	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2107
# text = Therefore, the phosphorylation of Rex is required for the viral RNA partition of HTLV-I.
1	Therefore	therefore	ADV	RB	_	_	_	_	SpaceAfter=No
2	,	,	PUNCT	,	_	_	_	_	_
3	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
4	phosphorylation	phosphorylation	NOUN	NN	Number=Sing	_	_	_	_
5	of	of	ADP	IN	_	_	_	_	_
6	Rex	Rex	PROPN	NNP	Number=Sing	_	_	_	_
7	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
8	required	require	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
9	for	for	ADP	IN	_	_	_	_	_
10	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
11	viral	viral	ADJ	JJ	Degree=Pos	_	_	_	_
12	RNA	RNA	NOUN	NN	Number=Sing	_	_	_	_
13	partition	partition	NOUN	NN	Number=Sing	_	_	_	_
14	of	of	ADP	IN	_	_	_	_	_
15	HTLV	HTLV	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
16	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
17	I	I	PRON	PRP	Case=Nom|Number=Sing|Person=1|PronType=Prs	_	_	_	SpaceAfter=No
18	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 2108
# text = Document 003003133 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	003003133	003003133	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 2109
# text = G(Anh)MTetra, a natural bacterial cell wall breakdown product, induces interleukin-1 beta and interleukin-6 expression in human monocytes.
1	G	G	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
2	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
3	Anh	Anh	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
4	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
5	MTetra	MTetra	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
6	,	,	PUNCT	,	_	_	_	_	_
7	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
8	natural	natural	ADJ	JJ	Degree=Pos	_	_	_	_
9	bacterial	bacterial	ADJ	JJ	Degree=Pos	_	_	_	_
10	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
11	wall	wall	NOUN	NN	Number=Sing	_	_	_	_
12	breakdown	breakdown	NOUN	NN	Number=Sing	_	_	_	_
13	product	product	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
14	,	,	PUNCT	,	_	_	_	_	_
15	induces	induce	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
16	interleukin	interleukin	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
17	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
18	1	1	NUM	CD	NumType=Card	_	_	_	_
19	beta	beta	NOUN	NN	Number=Sing	_	_	_	_
20	and	and	CCONJ	CC	_	_	_	_	_
21	interleukin	interleukin	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
22	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
23	6	6	NUM	CD	NumType=Card	_	_	_	_
24	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
25	in	in	ADP	IN	_	_	_	_	_
26	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
27	monocytes	monocyte	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
28	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2110
# text = A study of the molecular mechanisms involved in inflammatory cytokine expression [published erratum appears in J Biol Chem 1994 Jun 17;269(24):16983]
1	A	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
2	study	study	NOUN	NN	Number=Sing	_	_	_	_
3	of	of	ADP	IN	_	_	_	_	_
4	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
5	molecular	molecular	ADJ	JJ	Degree=Pos	_	_	_	_
6	mechanisms	mechanism	NOUN	NNS	Number=Plur	_	_	_	_
7	involved	involve	ADJ	JJ	Degree=Pos	_	_	_	_
8	in	in	ADP	IN	_	_	_	_	_
9	inflammatory	inflammatory	ADJ	JJ	Degree=Pos	_	_	_	_
10	cytokine	cytokine	NOUN	NN	Number=Sing	_	_	_	_
11	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
12	[	[	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
13	published	publish	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
14	erratum	erratum	NOUN	NN	Number=Sing	_	_	_	_
15	appears	appear	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
16	in	in	ADP	IN	_	_	_	_	_
17	J	j	PROPN	NNP	Number=Sing	_	_	_	_
18	Biol	Biol	PROPN	NNP	Number=Sing	_	_	_	_
19	Chem	Chem	PROPN	NNP	Number=Sing	_	_	_	_
20	1994	1994	NUM	CD	NumType=Card	_	_	_	_
21	Jun	Jun	PROPN	NNP	Number=Sing	_	_	_	_
22	17;269	17;269	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
23	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
24	24)	24)	SYM	NFP	_	_	_	_	SpaceAfter=No
25	:16983	:16983	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
26	]	]	PUNCT	-RRB-	_	_	_	_	SpacesAfter=\s\n

# sent_id = 2111
# text = It is believed that induction of cytokine expression by bacterial cell wall components plays a role in the development and course of sepsis.
1	It	it	PRON	PRP	Case=Nom|Gender=Neut|Number=Sing|Person=3|PronType=Prs	_	_	_	_
2	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
3	believed	believe	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
4	that	that	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
5	induction	induction	NOUN	NN	Number=Sing	_	_	_	_
6	of	of	ADP	IN	_	_	_	_	_
7	cytokine	cytokine	NOUN	NN	Number=Sing	_	_	_	_
8	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
9	by	by	ADP	IN	_	_	_	_	_
10	bacterial	bacterial	ADJ	JJ	Degree=Pos	_	_	_	_
11	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
12	wall	wall	NOUN	NN	Number=Sing	_	_	_	_
13	components	component	NOUN	NNS	Number=Plur	_	_	_	_
14	plays	play	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
15	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
16	role	role	NOUN	NN	Number=Sing	_	_	_	_
17	in	in	ADP	IN	_	_	_	_	_
18	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
19	development	development	NOUN	NN	Number=Sing	_	_	_	_
20	and	and	CCONJ	CC	_	_	_	_	_
21	course	course	NOUN	NN	Number=Sing	_	_	_	_
22	of	of	ADP	IN	_	_	_	_	_
23	sepsis	sepsis	PRON	DT	Number=Sing|PronType=Dem	_	_	_	SpaceAfter=No
24	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2112
# text = However, most attention has been focused on lipopolysaccharide (LPS).
1	However	however	ADV	RB	_	_	_	_	SpaceAfter=No
2	,	,	PUNCT	,	_	_	_	_	_
3	most	most	ADJ	JJS	Degree=Sup	_	_	_	_
4	attention	attention	NOUN	NN	Number=Sing	_	_	_	_
5	has	have	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
6	been	be	AUX	VBN	Tense=Past|VerbForm=Part	_	_	_	_
7	focused	focus	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
8	on	on	ADP	IN	_	_	_	_	_
9	lipopolysaccharide	lipopolysaccharide	NOUN	NN	Number=Sing	_	_	_	_
10	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
11	LPS	LPS	INTJ	UH	_	_	_	_	SpaceAfter=No
12	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
13	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2113
# text = We studied the ability of N-acetylglucosaminyl-1,6-anhydro-N-acetylmuramyl-L-alanyl-D- isoglutamyl-m-diaminopimelyl-D-alanine (G(Anh)MTetra), a naturally occurring breakdown product of peptidoglycan that is produced by soluble lytic transglycosylase of Escherichia coli, to induce cytokine expression in human monocytes.
1	We	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
2	studied	study	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
3	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
4	ability	ability	NOUN	NN	Number=Sing	_	_	_	_
5	of	of	ADP	IN	_	_	_	_	_
6	N-acetylglucosaminyl	N-acetylglucosaminyl	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
7	-1,6-anhydro-N-acetylmuramyl-L-	-1,6-anhydro-N-acetylmuramyl-L-	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
8	alanyl	alanyl	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
9	-D	-d	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
10	-	-	PUNCT	HYPH	_	_	_	_	_
11	isoglutamyl	isoglutamyl	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
12	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
13	m-diaminopimelyl	m-diaminopimelyl	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
14	-D-	-d-	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
15	alanine	alanine	NUM	CD	NumType=Card	_	_	_	_
16	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
17	G	g	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
18	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
19	Anh	Anh	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
20	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
21	MTetra	MTetra	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
22	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
23	,	,	PUNCT	,	_	_	_	_	_
24	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
25	naturally	naturally	NOUN	NN	Number=Sing	_	_	_	_
26	occurring	occurre	VERB	VBG	VerbForm=Ger	_	_	_	_
27	breakdown	breakdown	ADP	IN	_	_	_	_	_
28	product	product	NOUN	NN	Number=Sing	_	_	_	_
29	of	of	ADP	IN	_	_	_	_	_
30	peptidoglycan	peptidoglycan	NOUN	NN	Number=Sing	_	_	_	_
31	that	that	PRON	WDT	PronType=Rel	_	_	_	_
32	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
33	produced	produce	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
34	by	by	ADP	IN	_	_	_	_	_
35	soluble	soluble	ADJ	JJ	Degree=Pos	_	_	_	_
36	lytic	lytic	ADJ	JJ	Degree=Pos	_	_	_	_
37	transglycosylase	transglycosylase	NOUN	NN	Number=Sing	_	_	_	_
38	of	of	ADP	IN	_	_	_	_	_
39	Escherichia	Escherichia	PROPN	NNP	Number=Sing	_	_	_	_
40	coli	coli	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
41	,	,	PUNCT	,	_	_	_	_	_
42	to	to	PART	TO	_	_	_	_	_
43	induce	induce	VERB	VB	VerbForm=Inf	_	_	_	_
44	cytokine	cytokine	NOUN	NN	Number=Sing	_	_	_	_
45	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
46	in	in	ADP	IN	_	_	_	_	_
47	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
48	monocytes	monocyte	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
49	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2114
# text = G(Anh)MTetra was found to strongly induce interleukin (IL)-1 beta and IL-6 mRNA expression after 2 h and IL-1 beta and IL-6 protein secretion after 48 h of activation.
1	G	G	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
2	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
3	Anh	Anh	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
4	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
5	MTetra	MTetra	PROPN	NNP	Number=Sing	_	_	_	_
6	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
7	found	find	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
8	to	to	PART	TO	_	_	_	_	_
9	strongly	strongly	ADV	RB	_	_	_	_	_
10	induce	induce	VERB	VB	VerbForm=Inf	_	_	_	_
11	interleukin	interleukin	NOUN	NN	Number=Sing	_	_	_	_
12	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
13	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
14	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
15	-	-	SYM	SYM	_	_	_	_	SpaceAfter=No
16	1	1	NUM	CD	NumType=Card	_	_	_	_
17	beta	beta	NOUN	NN	Number=Sing	_	_	_	_
18	and	and	CCONJ	CC	_	_	_	_	_
19	IL	Il	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
20	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
21	6	6	NUM	CD	NumType=Card	_	_	_	_
22	mRNA	mRNa	NOUN	NN	Number=Sing	_	_	_	_
23	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
24	after	after	ADP	IN	_	_	_	_	_
25	2	2	NUM	CD	NumType=Card	_	_	_	_
26	h	h	NOUN	NN	Number=Sing	_	_	_	_
27	and	and	CCONJ	CC	_	_	_	_	_
28	IL	Il	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
29	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
30	1	1	NUM	CD	NumType=Card	_	_	_	_
31	beta	beta	NOUN	NN	Number=Sing	_	_	_	_
32	and	and	CCONJ	CC	_	_	_	_	_
33	IL	Il	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
34	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
35	6	6	NUM	CD	NumType=Card	_	_	_	_
36	protein	protein	NOUN	NN	Number=Sing	_	_	_	_
37	secretion	secretion	NOUN	NN	Number=Sing	_	_	_	_
38	after	after	ADP	IN	_	_	_	_	_
39	48	48	NUM	CD	NumType=Card	_	_	_	_
40	h	h	NOUN	NN	Number=Sing	_	_	_	_
41	of	of	ADP	IN	_	_	_	_	_
42	activation	activation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
43	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2115
# text = The increase in mRNA accumulation was at least partly due to an increase in the transcription rates of the respective genes and was accompanied by a strong induction of nuclear factor-kappa B and activator protein-1 transcription factor expression.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	increase	increase	NOUN	NN	Number=Sing	_	_	_	_
3	in	in	ADP	IN	_	_	_	_	_
4	mRNA	mRNA	PROPN	NNP	Number=Sing	_	_	_	_
5	accumulation	accumulation	NOUN	NN	Number=Sing	_	_	_	_
6	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
7	at	at	ADV	RB	_	_	_	_	_
8	least	least	ADV	RBS	Degree=Sup	_	_	_	_
9	partly	partly	ADV	RB	_	_	_	_	_
10	due	due	ADP	IN	_	_	_	_	_
11	to	to	ADP	IN	_	_	_	_	_
12	an	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
13	increase	increase	NOUN	NN	Number=Sing	_	_	_	_
14	in	in	ADP	IN	_	_	_	_	_
15	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
16	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
17	rates	rate	NOUN	NNS	Number=Plur	_	_	_	_
18	of	of	ADP	IN	_	_	_	_	_
19	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
20	respective	respective	ADJ	JJ	Degree=Pos	_	_	_	_
21	genes	gene	NOUN	NNS	Number=Plur	_	_	_	_
22	and	and	CCONJ	CC	_	_	_	_	_
23	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
24	accompanied	accompany	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
25	by	by	ADP	IN	_	_	_	_	_
26	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
27	strong	strong	ADJ	JJ	Degree=Pos	_	_	_	_
28	induction	induction	NOUN	NN	Number=Sing	_	_	_	_
29	of	of	ADP	IN	_	_	_	_	_
30	nuclear	nuclear	ADJ	JJ	Degree=Pos	_	_	_	_
31	factor	factor	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
32	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
33	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_
34	B	b	NOUN	NN	Number=Sing	_	_	_	_
35	and	and	CCONJ	CC	_	_	_	_	_
36	activator	activator	NOUN	NN	Number=Sing	_	_	_	_
37	protein	protein	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
38	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
39	1	1	NUM	CD	NumType=Card	_	_	_	_
40	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
41	factor	factor	NOUN	NN	Number=Sing	_	_	_	_
42	expression	expression	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
43	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2116
# text = Experiments using inhibitors of protein kinase C, protein kinase A, and tyrosine kinase-dependent pathways revealed that G(Anh)MTetra-induced IL-1 beta and IL-6 mRNA expression involves activation of an H7-inhibitable pathway.
1	Experiments	Experiment	NOUN	NNS	Number=Plur	_	_	_	_
2	using	use	VERB	VBG	VerbForm=Ger	_	_	_	_
3	inhibitors	inhibitor	NOUN	NNS	Number=Plur	_	_	_	_
4	of	of	ADP	IN	_	_	_	_	_
5	protein	protein	NOUN	NN	Number=Sing	_	_	_	_
6	kinase	kinase	NOUN	NN	Number=Sing	_	_	_	_
7	C	C	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
8	,	,	PUNCT	,	_	_	_	_	_
9	protein	protein	NOUN	NN	Number=Sing	_	_	_	_
10	kinase	kinase	NOUN	NN	Number=Sing	_	_	_	_
11	A	a	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
12	,	,	PUNCT	,	_	_	_	_	_
13	and	and	CCONJ	CC	_	_	_	_	_
14	tyrosine	tyrosine	NOUN	NN	Number=Sing	_	_	_	_
15	kinase	kinase	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
16	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
17	dependent	dependent	ADJ	JJ	Degree=Pos	_	_	_	_
18	pathways	pathway	NOUN	NNS	Number=Plur	_	_	_	_
19	revealed	reveal	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
20	that	that	SCONJ	IN	_	_	_	_	_
21	G	G	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
22	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
23	Anh	Anh	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
24	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
25	MTetra	MTetra	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
26	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
27	induced	induce	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
28	IL	Il	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
29	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
30	1	1	NUM	CD	NumType=Card	_	_	_	_
31	beta	beta	NOUN	NN	Number=Sing	_	_	_	_
32	and	and	CCONJ	CC	_	_	_	_	_
33	IL	Il	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
34	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
35	6	6	NUM	CD	NumType=Card	_	_	_	_
36	mRNA	mRNa	NOUN	NN	Number=Sing	_	_	_	_
37	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
38	involves	involf	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
39	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
40	of	of	ADP	IN	_	_	_	_	_
41	an	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
42	H7	H7	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
43	-inhibitable	-inhibitable	ADJ	JJ	Degree=Pos	_	_	_	_
44	pathway	pathway	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
45	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2117
# text = By using the protein synthesis inhibitor cycloheximide, it was shown that G(Anh)MTetra-induced IL-6 mRNA expression depends on the synthesis of new protein, whereas G(Anh)MTetra-induced IL-1 beta mRNA accumulation does not.
1	By	by	SCONJ	IN	_	_	_	_	_
2	using	use	VERB	VBG	VerbForm=Ger	_	_	_	_
3	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
4	protein	protein	NOUN	NN	Number=Sing	_	_	_	_
5	synthesis	synthesis	NOUN	NN	Number=Sing	_	_	_	_
6	inhibitor	inhibitor	NOUN	NN	Number=Sing	_	_	_	_
7	cycloheximide	cycloheximide	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
8	,	,	PUNCT	,	_	_	_	_	_
9	it	it	PRON	PRP	Case=Nom|Gender=Neut|Number=Sing|Person=3|PronType=Prs	_	_	_	_
10	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
11	shown	show	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
12	that	that	SCONJ	IN	_	_	_	_	_
13	G	G	VERB	VBG	VerbForm=Ger	_	_	_	SpaceAfter=No
14	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
15	Anh	Anh	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
16	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
17	MTetra	MTetra	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
18	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
19	induced	induce	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
20	IL	Il	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
21	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
22	6	6	NUM	CD	NumType=Card	_	_	_	_
23	mRNA	mRNA	NOUN	NN	Number=Sing	_	_	_	_
24	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
25	depends	depend	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
26	on	on	ADP	IN	_	_	_	_	_
27	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
28	synthesis	synthesis	NOUN	NN	Number=Sing	_	_	_	_
29	of	of	ADP	IN	_	_	_	_	_
30	new	new	ADJ	JJ	Degree=Pos	_	_	_	_
31	protein	protein	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
32	,	,	PUNCT	,	_	_	_	_	_
33	whereas	whereas	SCONJ	IN	_	_	_	_	_
34	G	G	VERB	VBG	VerbForm=Ger	_	_	_	SpaceAfter=No
35	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
36	Anh	Anh	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
37	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
38	MTetra	MTetra	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
39	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
40	induced	induce	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
41	IL	Il	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
42	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
43	1	1	NUM	CD	NumType=Card	_	_	_	_
44	beta	beta	NOUN	NN	Number=Sing	_	_	_	_
45	mRNA	mRNa	SYM	SYM	_	_	_	_	_
46	accumulation	accumulation	NOUN	NN	Number=Sing	_	_	_	_
47	does	do	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
48	not	not	PART	RB	_	_	_	_	SpaceAfter=No
49	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2118
# text = When responses to G(Anh)MTetra were compared with those to LPS and muramyldipeptide (MDP), it was found that the optimal response to G(Anh)MTetra induction was similar to that of LPS but significantly higher than the response to MDP.
1	When	when	ADV	WRB	PronType=Int	_	_	_	_
2	responses	response	NOUN	NNS	Number=Plur	_	_	_	_
3	to	to	ADP	IN	_	_	_	_	_
4	G	G	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
5	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
6	Anh	Anh	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
7	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
8	MTetra	MTetra	PROPN	NNP	Number=Sing	_	_	_	_
9	were	be	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
10	compared	compare	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
11	with	with	ADP	IN	_	_	_	_	_
12	those	those	PRON	DT	Number=Plur|PronType=Dem	_	_	_	_
13	to	to	ADP	IN	_	_	_	_	_
14	LPS	LPS	NOUN	NNS	Number=Plur	_	_	_	_
15	and	and	CCONJ	CC	_	_	_	_	_
16	muramyldipeptide	muramyldipeptide	NOUN	NN	Number=Sing	_	_	_	_
17	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
18	MDP	MDP	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
19	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
20	,	,	PUNCT	,	_	_	_	_	_
21	it	it	PRON	PRP	Case=Nom|Gender=Neut|Number=Sing|Person=3|PronType=Prs	_	_	_	_
22	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
23	found	find	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
24	that	that	SCONJ	IN	_	_	_	_	_
25	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
26	optimal	optimal	ADJ	JJ	Degree=Pos	_	_	_	_
27	response	response	NOUN	NN	Number=Sing	_	_	_	_
28	to	to	ADP	IN	_	_	_	_	_
29	G	G	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
30	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
31	Anh	Anh	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
32	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
33	MTetra	MTetra	PROPN	NNP	Number=Sing	_	_	_	_
34	induction	induction	NOUN	NN	Number=Sing	_	_	_	_
35	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
36	similar	similar	ADJ	JJ	Degree=Pos	_	_	_	_
37	to	to	ADP	IN	_	_	_	_	_
38	that	that	PRON	DT	Number=Sing|PronType=Dem	_	_	_	_
39	of	of	ADP	IN	_	_	_	_	_
40	LPS	LPS	NOUN	NN	Number=Sing	_	_	_	_
41	but	but	CCONJ	CC	_	_	_	_	_
42	significantly	significantly	ADV	RB	_	_	_	_	_
43	higher	higher	ADJ	JJR	Degree=Cmp	_	_	_	_
44	than	than	ADP	IN	_	_	_	_	_
45	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
46	response	response	NOUN	NN	Number=Sing	_	_	_	_
47	to	to	ADP	IN	_	_	_	_	_
48	MDP	MDP	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
49	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2119
# text = Furthermore, maximal G(Anh)MTetra-induced IL-1 beta and IL-6 mRNA expression could be enhanced by co-stimulation with LPS or MDP, suggesting that different receptors and/or transduction pathways were involved.
1	Furthermore	furthermore	ADV	RB	_	_	_	_	SpaceAfter=No
2	,	,	PUNCT	,	_	_	_	_	_
3	maximal	maximal	ADJ	JJ	Degree=Pos	_	_	_	_
4	G	G	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
5	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
6	Anh	Anh	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
7	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
8	MTetra	MTetra	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
9	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
10	induced	induce	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
11	IL	Il	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
12	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
13	1	1	NUM	CD	NumType=Card	_	_	_	_
14	beta	beta	NOUN	NN	Number=Sing	_	_	_	_
15	and	and	CCONJ	CC	_	_	_	_	_
16	IL	Il	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
17	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
18	6	6	NUM	CD	NumType=Card	_	_	_	_
19	mRNA	mRNa	NOUN	NN	Number=Sing	_	_	_	_
20	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
21	could	could	AUX	MD	VerbForm=Fin	_	_	_	_
22	be	be	AUX	VB	VerbForm=Inf	_	_	_	_
23	enhanced	enhance	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
24	by	by	ADP	IN	_	_	_	_	_
25	co-stimulation	co-stimulation	NOUN	NN	Number=Sing	_	_	_	_
26	with	with	ADP	IN	_	_	_	_	_
27	LPS	Lps	PROPN	NNP	Number=Sing	_	_	_	_
28	or	or	CCONJ	CC	_	_	_	_	_
29	MDP	Mdp	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
30	,	,	PUNCT	,	_	_	_	_	_
31	suggesting	suggest	VERB	VBG	VerbForm=Ger	_	_	_	_
32	that	that	SCONJ	IN	_	_	_	_	_
33	different	different	ADJ	JJ	Degree=Pos	_	_	_	_
34	receptors	receptor	NOUN	NNS	Number=Plur	_	_	_	_
35	and	and	CCONJ	CC	_	_	_	_	SpaceAfter=No
36	/	/	PUNCT	,	_	_	_	_	SpaceAfter=No
37	or	or	CCONJ	CC	_	_	_	_	_
38	transduction	transduction	NOUN	NN	Number=Sing	_	_	_	_
39	pathways	pathway	NOUN	NNS	Number=Plur	_	_	_	_
40	were	be	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
41	involved	involved	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
42	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2120
# text = These results indicate that G(Anh)MTetra induces IL-1 beta and IL-6 expression in human monocytes suggesting a possible role for G(Anh)MTetra in the release of cytokines during sepsis.
1	These	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
2	results	result	NOUN	NNS	Number=Plur	_	_	_	_
3	indicate	indicate	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
4	that	that	SCONJ	IN	_	_	_	_	_
5	G	G	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
6	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
7	Anh	Anh	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
8	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
9	MTetra	MTetra	PROPN	NNP	Number=Sing	_	_	_	_
10	induces	induce	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
11	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
12	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
13	1	1	NUM	CD	NumType=Card	_	_	_	_
14	beta	beta	NOUN	NN	Number=Sing	_	_	_	_
15	and	and	CCONJ	CC	_	_	_	_	_
16	IL	Il	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
17	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
18	6	6	NUM	CD	NumType=Card	_	_	_	_
19	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
20	in	in	ADP	IN	_	_	_	_	_
21	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
22	monocytes	monocyte	NOUN	NNS	Number=Plur	_	_	_	_
23	suggesting	suggest	VERB	VBG	VerbForm=Ger	_	_	_	_
24	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
25	possible	possible	ADJ	JJ	Degree=Pos	_	_	_	_
26	role	role	NOUN	NN	Number=Sing	_	_	_	_
27	for	for	ADP	IN	_	_	_	_	_
28	G	G	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
29	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
30	Anh	Anh	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
31	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
32	MTetra	MTetra	PROPN	NNP	Number=Sing	_	_	_	_
33	in	in	ADP	IN	_	_	_	_	_
34	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
35	release	release	NOUN	NN	Number=Sing	_	_	_	_
36	of	of	ADP	IN	_	_	_	_	_
37	cytokines	cytokine	NOUN	NNS	Number=Plur	_	_	_	_
38	during	during	ADP	IN	_	_	_	_	_
39	sepsis.	sepsis.	NOUN	NN	Number=Sing	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 2121
# text = Document 003003134 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	003003134	003003134	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 2122
# text = C/EBP beta in rheumatoid arthritis: correlation with inflammation, not disease specificity.
1	C	C	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
2	/	/	PUNCT	,	_	_	_	_	SpaceAfter=No
3	EBP	EBP	PROPN	NNP	Number=Sing	_	_	_	_
4	beta	beta	NOUN	NN	Number=Sing	_	_	_	_
5	in	in	ADP	IN	_	_	_	_	_
6	rheumatoid	rheumatoid	ADJ	JJ	Degree=Pos	_	_	_	_
7	arthritis	arthritis	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
8	:	:	PUNCT	:	_	_	_	_	_
9	correlation	correlation	NOUN	NN	Number=Sing	_	_	_	_
10	with	with	ADP	IN	_	_	_	_	_
11	inflammation	inflammation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
12	,	,	PUNCT	,	_	_	_	_	_
13	not	not	ADV	RB	_	_	_	_	_
14	disease	disease	NOUN	NN	Number=Sing	_	_	_	_
15	specificity	specificity	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
16	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 2123
# text = Rheumatoid arthritis synovial tissue was examined and compared with osteoarthritis tissue for the presence of the nuclear transcription factor C/EBP beta (NF-IL-6).
1	Rheumatoid	Rheumatoid	VERB	VB	Mood=Imp|VerbForm=Fin	_	_	_	_
2	arthritis	arthritis	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
3	synovial	synovial	ADJ	JJ	Degree=Pos	_	_	_	_
4	tissue	tissue	NOUN	NN	Number=Sing	_	_	_	_
5	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
6	examined	examin	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
7	and	and	CCONJ	CC	_	_	_	_	_
8	compared	compare	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
9	with	with	ADP	IN	_	_	_	_	_
10	osteoarthritis	osteoarthritis	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
11	tissue	tissue	NOUN	NN	Number=Sing	_	_	_	_
12	for	for	ADP	IN	_	_	_	_	_
13	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
14	presence	presence	NOUN	NN	Number=Sing	_	_	_	_
15	of	of	ADP	IN	_	_	_	_	_
16	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
17	nuclear	nuclear	ADJ	JJ	Degree=Pos	_	_	_	_
18	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
19	factor	factor	NOUN	NN	Number=Sing	_	_	_	_
20	C/	Cith	ADP	IN	Abbr=Yes	_	_	_	SpaceAfter=No
21	EBP	EBP	PROPN	NNP	Number=Sing	_	_	_	_
22	beta	beta	PROPN	NNP	Number=Sing	_	_	_	_
23	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
24	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
25	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
26	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
27	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
28	6	6	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
29	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
30	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2124
# text = The region (lining or sublining), cell type, and subcellular distribution (cytoplasmic or nuclear) of the expression of C/EBP beta was characterized.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	region	region	NOUN	NN	Number=Sing	_	_	_	_
3	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
4	lining	lin	NOUN	NN	Number=Sing	_	_	_	_
5	or	or	CCONJ	CC	_	_	_	_	_
6	sublining	sublin	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
7	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
8	,	,	PUNCT	,	_	_	_	_	_
9	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
10	type	type	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
11	,	,	PUNCT	,	_	_	_	_	_
12	and	and	CCONJ	CC	_	_	_	_	_
13	subcellular	subcelular	ADJ	JJ	Degree=Pos	_	_	_	_
14	distribution	distribution	NOUN	NN	Number=Sing	_	_	_	_
15	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
16	cytoplasmic	cytoplasmic	ADJ	JJ	Degree=Pos	_	_	_	_
17	or	or	CCONJ	CC	_	_	_	_	_
18	nuclear	nuclear	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
19	)	)	PUNCT	-RRB-	_	_	_	_	_
20	of	of	ADP	IN	_	_	_	_	_
21	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
22	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
23	of	of	ADP	IN	_	_	_	_	_
24	C	C	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
25	/	/	PUNCT	,	_	_	_	_	SpaceAfter=No
26	EBP	EBP	PROPN	NNP	Number=Sing	_	_	_	_
27	beta	beta	PROPN	NNP	Number=Sing	_	_	_	_
28	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
29	characterized	characterize	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	SpaceAfter=No
30	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2125
# text = Rheumatoid arthritis synovial fluid and blood and normal peripheral blood were also examined.
1	Rheumatoid	Rheumatoid	VERB	VB	Mood=Imp|VerbForm=Fin	_	_	_	_
2	arthritis	arthritis	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
3	synovial	synovial	ADJ	JJ	Degree=Pos	_	_	_	_
4	fluid	fluid	NOUN	NN	Number=Sing	_	_	_	_
5	and	and	CCONJ	CC	_	_	_	_	_
6	blood	blood	NOUN	NN	Number=Sing	_	_	_	_
7	and	and	CCONJ	CC	_	_	_	_	_
8	normal	normal	ADJ	JJ	Degree=Pos	_	_	_	_
9	peripheral	peripheral	ADJ	JJ	Degree=Pos	_	_	_	_
10	blood	blood	NOUN	NN	Number=Sing	_	_	_	_
11	were	be	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
12	also	also	ADV	RB	_	_	_	_	_
13	examined	examin	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	SpaceAfter=No
14	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2126
# text = C/EBP beta was detected in the synovial lining and in sublining cells of synovial tissue from patients with both rheumatoid and osteoarthritis.
1	C/	C/	SYM	NFP	_	_	_	_	SpaceAfter=No
2	EBP	EBP	PROPN	NNP	Number=Sing	_	_	_	_
3	beta	beta	PROPN	NNP	Number=Sing	_	_	_	_
4	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
5	detected	detect	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
6	in	in	ADP	IN	_	_	_	_	_
7	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
8	synovial	synovial	ADJ	JJ	Degree=Pos	_	_	_	_
9	lining	lining	NOUN	NN	Number=Sing	_	_	_	_
10	and	and	CCONJ	CC	_	_	_	_	_
11	in	in	ADP	IN	_	_	_	_	_
12	sublining	sublin	VERB	VBG	VerbForm=Ger	_	_	_	_
13	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
14	of	of	ADP	IN	_	_	_	_	_
15	synovial	synovial	ADJ	JJ	Degree=Pos	_	_	_	_
16	tissue	tissue	NOUN	NN	Number=Sing	_	_	_	_
17	from	from	ADP	IN	_	_	_	_	_
18	patients	patient	NOUN	NNS	Number=Plur	_	_	_	_
19	with	with	ADP	IN	_	_	_	_	_
20	both	both	CCONJ	CC	_	_	_	_	_
21	rheumatoid	rheumatoid	NOUN	NN	Number=Sing	_	_	_	_
22	and	and	CCONJ	CC	_	_	_	_	_
23	osteoarthritis	osteoarthritis	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
24	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2127
# text = A significant (P < 0.001 and < 0.05, respectively) increase in the percentage of cells with nuclear staining was seen in the lining layer, compared to cells in the sublining region, in rheumatoid and osteoarthritis.
1	A	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
2	significant	significant	ADJ	JJ	Degree=Pos	_	_	_	_
3	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
4	P	p	NOUN	NN	Number=Sing	_	_	_	_
5	<	<	PUNCT	-LRB-	_	_	_	_	_
6	0.001	0.001	NUM	CD	NumType=Card	_	_	_	_
7	and	and	CCONJ	CC	_	_	_	_	_
8	<	<	PUNCT	-LRB-	_	_	_	_	_
9	0.05	0.05	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
10	,	,	PUNCT	,	_	_	_	_	_
11	respectively	respectively	ADV	RB	_	_	_	_	SpaceAfter=No
12	)	)	PUNCT	-RRB-	_	_	_	_	_
13	increase	increase	NOUN	NN	Number=Sing	_	_	_	_
14	in	in	ADP	IN	_	_	_	_	_
15	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
16	percentage	percentage	NOUN	NN	Number=Sing	_	_	_	_
17	of	of	ADP	IN	_	_	_	_	_
18	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
19	with	with	ADP	IN	_	_	_	_	_
20	nuclear	nuclear	ADJ	JJ	Degree=Pos	_	_	_	_
21	staining	staining	NOUN	NN	Number=Sing	_	_	_	_
22	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
23	seen	see	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
24	in	in	ADP	IN	_	_	_	_	_
25	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
26	lining	lining	NOUN	NN	Number=Sing	_	_	_	_
27	layer	layer	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
28	,	,	PUNCT	,	_	_	_	_	_
29	compared	compare	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
30	to	to	ADP	IN	_	_	_	_	_
31	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
32	in	in	ADP	IN	_	_	_	_	_
33	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
34	sublining	sublining	NOUN	NN	Number=Sing	_	_	_	_
35	region	region	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
36	,	,	PUNCT	,	_	_	_	_	_
37	in	in	ADP	IN	_	_	_	_	_
38	rheumatoid	rheumatoid	NOUN	NN	Number=Sing	_	_	_	_
39	and	and	CCONJ	CC	_	_	_	_	_
40	osteoarthritis	osteoarthritis	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
41	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2128
# text = In both diseases a strong correlation (r = 0.79, P < 0.001) was observed between the percentage of cells in the synovial lining that were positive for nuclear C/EBP beta and lining cell depth.
1	In	in	ADP	IN	_	_	_	_	_
2	both	both	DET	DT	_	_	_	_	_
3	diseases	diseasis	NOUN	NNS	Number=Plur	_	_	_	_
4	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
5	strong	strong	ADJ	JJ	Degree=Pos	_	_	_	_
6	correlation	correlation	NOUN	NN	Number=Sing	_	_	_	_
7	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
8	r	be	NOUN	NN	Number=Sing	_	_	_	_
9	=	=	SYM	SYM	_	_	_	_	_
10	0.79	0.79	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
11	,	,	PUNCT	,	_	_	_	_	_
12	P	P	NOUN	NN	Number=Sing	_	_	_	_
13	<	<	PUNCT	-LRB-	_	_	_	_	_
14	0.001	0.001	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
15	)	)	PUNCT	-RRB-	_	_	_	_	_
16	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
17	observed	observe	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
18	between	between	ADP	IN	_	_	_	_	_
19	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
20	percentage	percentage	NOUN	NN	Number=Sing	_	_	_	_
21	of	of	ADP	IN	_	_	_	_	_
22	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
23	in	in	ADP	IN	_	_	_	_	_
24	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
25	synovial	synovial	ADJ	JJ	Degree=Pos	_	_	_	_
26	lining	lining	NOUN	NN	Number=Sing	_	_	_	_
27	that	that	PRON	WDT	PronType=Rel	_	_	_	_
28	were	be	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
29	positive	positive	ADJ	JJ	Degree=Pos	_	_	_	_
30	for	for	ADP	IN	_	_	_	_	_
31	nuclear	nuclear	ADJ	JJ	Degree=Pos	_	_	_	_
32	C	C	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
33	/	/	PUNCT	,	_	_	_	_	SpaceAfter=No
34	EBP	EBP	PROPN	NNP	Number=Sing	_	_	_	_
35	beta	beta	NOUN	NN	Number=Sing	_	_	_	_
36	and	and	CCONJ	CC	_	_	_	_	_
37	lining	lin	VERB	VBG	VerbForm=Ger	_	_	_	_
38	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
39	depth	depth	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
40	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2129
# text = Two-color immunohistochemistry demonstrated that both macrophages and fibroblast-like synoviocytes were positive for nuclear C/EBP beta.
1	Two	two	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
2	-	-	PUNCT	:	_	_	_	_	SpaceAfter=No
3	color	color	NOUN	NN	Number=Sing	_	_	_	_
4	immunohistochemistry	immunohistochemistry	NOUN	NN	Number=Sing	_	_	_	_
5	demonstrated	demonstrate	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
6	that	that	SCONJ	IN	_	_	_	_	_
7	both	both	DET	DT	_	_	_	_	_
8	macrophages	macrophage	NOUN	NNS	Number=Plur	_	_	_	_
9	and	and	CCONJ	CC	_	_	_	_	_
10	fibroblast	fibroblast	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
11	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
12	like	like	SCONJ	IN	_	_	_	_	_
13	synoviocytes	synoviocyte	NOUN	NNS	Number=Plur	_	_	_	_
14	were	be	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
15	positive	positive	ADJ	JJ	Degree=Pos	_	_	_	_
16	for	for	ADP	IN	_	_	_	_	_
17	nuclear	nuclear	ADJ	JJ	Degree=Pos	_	_	_	_
18	C/	c/	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
19	EBP	EBP	NOUN	NN	Number=Sing	_	_	_	_
20	beta	beta	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
21	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2130
# text = The presence of C/EBP beta was confirmed by immunohistochemistry and Western blot analysis with isolated synovial fibroblasts.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	presence	presence	NOUN	NN	Number=Sing	_	_	_	_
3	of	of	ADP	IN	_	_	_	_	_
4	C	C	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
5	/	/	PUNCT	,	_	_	_	_	SpaceAfter=No
6	EBP	EBP	PROPN	NNP	Number=Sing	_	_	_	_
7	beta	beta	PROPN	NNP	Number=Sing	_	_	_	_
8	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
9	confirmed	confirm	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
10	by	by	ADP	IN	_	_	_	_	_
11	immunohistochemistry	immunohistochemistry	ADJ	JJ	Degree=Pos	_	_	_	_
12	and	and	CCONJ	CC	_	_	_	_	_
13	Western	western	ADJ	JJ	Degree=Pos	_	_	_	_
14	blot	blot	NOUN	NN	Number=Sing	_	_	_	_
15	analysis	analysis	NOUN	NN	Number=Sing	_	_	_	_
16	with	with	ADP	IN	_	_	_	_	_
17	isolated	isolate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
18	synovial	synovial	ADJ	JJ	Degree=Pos	_	_	_	_
19	fibroblasts	fibroblast	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
20	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2131
# text = Nuclear C/EBP beta was also detected in rheumatoid synovial fluid monocytes/macrophages, but not in lymphocytes or neutrophils.
1	Nuclear	nuclear	ADJ	JJ	Degree=Pos	_	_	_	_
2	C/	c/	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
3	EBP	EBP	PROPN	NNP	Number=Sing	_	_	_	_
4	beta	beta	PROPN	NNP	Number=Sing	_	_	_	_
5	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
6	also	also	ADV	RB	_	_	_	_	_
7	detected	detect	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
8	in	in	ADP	IN	_	_	_	_	_
9	rheumatoid	rheumatoid	ADJ	JJ	Degree=Pos	_	_	_	_
10	synovial	synovial	ADJ	JJ	Degree=Pos	_	_	_	_
11	fluid	fluid	NOUN	NN	Number=Sing	_	_	_	_
12	monocytes	monocyte	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
13	/	/	PUNCT	,	_	_	_	_	SpaceAfter=No
14	macrophages	macrophage	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
15	,	,	PUNCT	,	_	_	_	_	_
16	but	but	CCONJ	CC	_	_	_	_	_
17	not	not	ADV	RB	_	_	_	_	_
18	in	in	ADP	IN	_	_	_	_	_
19	lymphocytes	lymphocyte	NOUN	NNS	Number=Plur	_	_	_	_
20	or	or	CCONJ	CC	_	_	_	_	_
21	neutrophils	neutrophil	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
22	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2132
# text = Western blot analysis confirmed the presence of C/EBP beta in these cells.
1	Western	western	ADJ	JJ	Degree=Pos	_	_	_	_
2	blot	blot	NOUN	NN	Number=Sing	_	_	_	_
3	analysis	analysis	NOUN	NN	Number=Sing	_	_	_	_
4	confirmed	confirm	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
5	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
6	presence	presence	NOUN	NN	Number=Sing	_	_	_	_
7	of	of	ADP	IN	_	_	_	_	_
8	C	C	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
9	/	/	PUNCT	,	_	_	_	_	SpaceAfter=No
10	EBP	EBP	PROPN	NNP	Number=Sing	_	_	_	_
11	beta	beta	NOUN	NN	Number=Sing	_	_	_	_
12	in	in	ADP	IN	_	_	_	_	_
13	these	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
14	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
15	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2133
# text = The intensity of C/EBP beta staining was greater (P < 0.001) in synovial fluid monocytes than in those from normal or rheumatoid peripheral blood.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	intensity	intensity	NOUN	NN	Number=Sing	_	_	_	_
3	of	of	ADP	IN	_	_	_	_	_
4	C	C	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
5	/	/	PUNCT	,	_	_	_	_	SpaceAfter=No
6	EBP	EBP	PROPN	NNP	Number=Sing	_	_	_	_
7	beta	beta	NOUN	NN	Number=Sing	_	_	_	_
8	staining	staining	VERB	VBG	VerbForm=Ger	_	_	_	_
9	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
10	greater	greater	ADJ	JJR	Degree=Cmp	_	_	_	_
11	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
12	P	p	NOUN	NN	Number=Sing	_	_	_	_
13	<	<	PUNCT	-LRB-	_	_	_	_	_
14	0.001	0.001	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
15	)	)	PUNCT	-RRB-	_	_	_	_	_
16	in	in	ADP	IN	_	_	_	_	_
17	synovial	synovial	ADJ	JJ	Degree=Pos	_	_	_	_
18	fluid	fluid	NOUN	NN	Number=Sing	_	_	_	_
19	monocytes	monocyte	NOUN	NNS	Number=Plur	_	_	_	_
20	than	than	ADP	IN	_	_	_	_	_
21	in	in	ADP	IN	_	_	_	_	_
22	those	those	PRON	DT	Number=Plur|PronType=Dem	_	_	_	_
23	from	from	ADP	IN	_	_	_	_	_
24	normal	normal	ADJ	JJ	Degree=Pos	_	_	_	_
25	or	or	CCONJ	CC	_	_	_	_	_
26	rheumatoid	rheumatoid	ADJ	JJ	Degree=Pos	_	_	_	_
27	peripheral	peripheral	ADJ	JJ	Degree=Pos	_	_	_	_
28	blood	blood	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
29	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2134
# text = In conclusion, the enhanced nuclear staining for C/EBP beta in the synovial lining, compared to the sublining, suggesting activation in the lining, and the positive correlation of lining layer depth with the percentage of cells in the lining positive for nuclear C/EBP beta, suggest a potential role for C/EBP beta in chronic inflammation.
1	In	in	ADP	IN	_	_	_	_	_
2	conclusion	conclusion	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
3	,	,	PUNCT	,	_	_	_	_	_
4	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
5	enhanced	enhance	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
6	nuclear	nuclear	NOUN	NN	Number=Sing	_	_	_	_
7	staining	staining	VERB	VBG	VerbForm=Ger	_	_	_	_
8	for	for	ADP	IN	_	_	_	_	_
9	C	C	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
10	/	/	PUNCT	,	_	_	_	_	SpaceAfter=No
11	EBP	EBP	PROPN	NNP	Number=Sing	_	_	_	_
12	beta	beta	NOUN	NN	Number=Sing	_	_	_	_
13	in	in	ADP	IN	_	_	_	_	_
14	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
15	synovial	synovial	ADJ	JJ	Degree=Pos	_	_	_	_
16	lining	lining	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
17	,	,	PUNCT	,	_	_	_	_	_
18	compared	compare	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
19	to	to	ADP	IN	_	_	_	_	_
20	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
21	sublining	sublining	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
22	,	,	PUNCT	,	_	_	_	_	_
23	suggesting	suggest	VERB	VBG	VerbForm=Ger	_	_	_	_
24	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
25	in	in	ADP	IN	_	_	_	_	_
26	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
27	lining	lining	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
28	,	,	PUNCT	,	_	_	_	_	_
29	and	and	CCONJ	CC	_	_	_	_	_
30	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
31	positive	positive	ADJ	JJ	Degree=Pos	_	_	_	_
32	correlation	correlation	NOUN	NN	Number=Sing	_	_	_	_
33	of	of	SCONJ	IN	_	_	_	_	_
34	lining	lin	VERB	VBG	VerbForm=Ger	_	_	_	_
35	layer	layer	NOUN	NN	Number=Sing	_	_	_	_
36	depth	depth	NOUN	NN	Number=Sing	_	_	_	_
37	with	with	ADP	IN	_	_	_	_	_
38	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
39	percentage	percentage	NOUN	NN	Number=Sing	_	_	_	_
40	of	of	ADP	IN	_	_	_	_	_
41	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
42	in	in	ADP	IN	_	_	_	_	_
43	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
44	lining	lining	NOUN	NN	Number=Sing	_	_	_	_
45	positive	positive	ADJ	JJ	Degree=Pos	_	_	_	_
46	for	for	ADP	IN	_	_	_	_	_
47	nuclear	nuclear	ADJ	JJ	Degree=Pos	_	_	_	_
48	C	C	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
49	/	/	PUNCT	,	_	_	_	_	SpaceAfter=No
50	EBP	EBP	PROPN	NNP	Number=Sing	_	_	_	_
51	beta	beta	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
52	,	,	PUNCT	,	_	_	_	_	_
53	suggest	suggest	VERB	VB	Mood=Imp|VerbForm=Fin	_	_	_	_
54	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
55	potential	potential	ADJ	JJ	Degree=Pos	_	_	_	_
56	role	role	NOUN	NN	Number=Sing	_	_	_	_
57	for	for	ADP	IN	_	_	_	_	_
58	C	C	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
59	/	/	PUNCT	,	_	_	_	_	SpaceAfter=No
60	EBP	EBP	PROPN	NNP	Number=Sing	_	_	_	_
61	beta	beta	NOUN	NN	Number=Sing	_	_	_	_
62	in	in	ADP	IN	_	_	_	_	_
63	chronic	chronic	ADJ	JJ	Degree=Pos	_	_	_	_
64	inflammation	inflammation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
65	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2135
# text = The regulation of the production or activity of C/EBP beta, to inhibit inflammatory mediator expression by synovial macrophages and fibroblasts, offers a novel approach to therapeutic intervention.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	regulation	regulation	NOUN	NN	Number=Sing	_	_	_	_
3	of	of	ADP	IN	_	_	_	_	_
4	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
5	production	production	NOUN	NN	Number=Sing	_	_	_	_
6	or	or	CCONJ	CC	_	_	_	_	_
7	activity	activity	NOUN	NN	Number=Sing	_	_	_	_
8	of	of	ADP	IN	_	_	_	_	_
9	C	C	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
10	/	/	PUNCT	,	_	_	_	_	SpaceAfter=No
11	EBP	EBP	PROPN	NNP	Number=Sing	_	_	_	_
12	beta	beta	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
13	,	,	PUNCT	,	_	_	_	_	_
14	to	to	PART	TO	_	_	_	_	_
15	inhibit	inhibit	VERB	VB	VerbForm=Inf	_	_	_	_
16	inflammatory	inflammatory	ADJ	JJ	Degree=Pos	_	_	_	_
17	mediator	mediator	NOUN	NN	Number=Sing	_	_	_	_
18	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
19	by	by	ADP	IN	_	_	_	_	_
20	synovial	synovial	ADJ	JJ	Degree=Pos	_	_	_	_
21	macrophages	macrophage	NOUN	NNS	Number=Plur	_	_	_	_
22	and	and	CCONJ	CC	_	_	_	_	_
23	fibroblasts	fibroblast	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
24	,	,	PUNCT	,	_	_	_	_	_
25	offers	offer	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
26	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
27	novel	novel	NOUN	NN	Number=Sing	_	_	_	_
28	approach	approach	NOUN	NN	Number=Sing	_	_	_	_
29	to	to	ADP	IN	_	_	_	_	_
30	therapeutic	therapeutic	ADJ	JJ	Degree=Pos	_	_	_	_
31	intervention	intervention	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
32	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 2136
# text = Document 003003138 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	003003138	003003138	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 2137
# text = The activation of the Jak-STAT 1 signaling pathway by IL-5 in eosinophils.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
3	of	of	ADP	IN	_	_	_	_	_
4	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
5	Jak-	Jak-	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
6	STAT	Stat	NOUN	NN	Number=Sing	_	_	_	_
7	1	1	NUM	CD	NumType=Card	_	_	_	_
8	signaling	signal	NOUN	NN	Number=Sing	_	_	_	_
9	pathway	pathway	NOUN	NN	Number=Sing	_	_	_	_
10	by	by	ADP	IN	_	_	_	_	_
11	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
12	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
13	5	5	NUM	CD	NumType=Card	_	_	_	_
14	in	in	ADP	IN	_	_	_	_	_
15	eosinophils	eosinophil	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
16	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 2138
# text = The intracellular signal transduction of IL-5 in eosinophils is unknown.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	intracellular	intracellular	ADJ	JJ	Degree=Pos	_	_	_	_
3	signal	signal	NOUN	NN	Number=Sing	_	_	_	_
4	transduction	transduction	NOUN	NN	Number=Sing	_	_	_	_
5	of	of	ADP	IN	_	_	_	_	_
6	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
7	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
8	5	5	NUM	CD	NumType=Card	_	_	_	_
9	in	in	ADP	IN	_	_	_	_	_
10	eosinophils	eosinophil	NOUN	NNS	Number=Plur	_	_	_	_
11	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
12	unknown	unknown	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
13	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2139
# text = The objective of this study was to investigate the involvement of the newly discovered Jak-STAT pathway in the IL-5 signal transduction mechanism.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	objective	objective	NOUN	NN	Number=Sing	_	_	_	_
3	of	of	ADP	IN	_	_	_	_	_
4	this	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
5	study	study	NOUN	NN	Number=Sing	_	_	_	_
6	was	be	VERB	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
7	to	to	PART	TO	_	_	_	_	_
8	investigate	investigate	VERB	VB	VerbForm=Inf	_	_	_	_
9	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
10	involvement	involvement	NOUN	NN	Number=Sing	_	_	_	_
11	of	of	ADP	IN	_	_	_	_	_
12	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
13	newly	newly	ADV	RB	_	_	_	_	_
14	discovered	discover	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
15	Jak	Jak	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
16	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
17	STAT	STAT	PROPN	NNP	Number=Sing	_	_	_	_
18	pathway	pathway	NOUN	NN	Number=Sing	_	_	_	_
19	in	in	ADP	IN	_	_	_	_	_
20	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
21	IL	IL	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
22	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
23	5	5	NUM	CD	NumType=Card	_	_	_	_
24	signal	signal	NOUN	NN	Number=Sing	_	_	_	_
25	transduction	transduction	NOUN	NN	Number=Sing	_	_	_	_
26	mechanism	mechanism	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
27	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2140
# text = Eosinophils were purified from peripheral blood by discontinuous
1	Eosinophils	Eosinophil	NOUN	NNS	Number=Plur	_	_	_	_
2	were	be	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
3	purified	purify	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
4	from	from	ADP	IN	_	_	_	_	_
5	peripheral	peripheral	ADJ	JJ	Degree=Pos	_	_	_	_
6	blood	blood	NOUN	NN	Number=Sing	_	_	_	_
7	by	by	ADP	IN	_	_	_	_	_
8	discontinuous	discontinuous	ADJ	JJ	Degree=Pos	_	_	_	_

# sent_id = 2141
# text = Percoll gradients and stimulated with IL-5.
1	Percoll	Percoll	ADJ	JJ	Degree=Pos	_	_	_	_
2	gradients	gradient	NOUN	NNS	Number=Plur	_	_	_	_
3	and	and	CCONJ	CC	_	_	_	_	_
4	stimulated	stimulate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
5	with	with	ADP	IN	_	_	_	_	_
6	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
7	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
8	5	5	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
9	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2142
# text = The involvement of Jak 2 was investigated by immunoprecipitation followed by immunoblotting for tyrosine phosphorylation.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	involvement	involvement	NOUN	NN	Number=Sing	_	_	_	_
3	of	of	ADP	IN	_	_	_	_	_
4	Jak	Jak	PROPN	NNP	Number=Sing	_	_	_	_
5	2	2	NUM	CD	NumType=Card	_	_	_	_
6	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
7	investigated	investigate	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
8	by	by	ADP	IN	_	_	_	_	_
9	immunoprecipitation	immunoprecipitation	NOUN	NN	Number=Sing	_	_	_	_
10	followed	follow	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
11	by	by	SCONJ	IN	_	_	_	_	_
12	immunoblotting	immunoblott	VERB	VBG	VerbForm=Ger	_	_	_	_
13	for	for	ADP	IN	_	_	_	_	_
14	tyrosine	tyrosine	NOUN	NN	Number=Sing	_	_	_	_
15	phosphorylation	phosphorylation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
16	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2143
# text = The activation of Jak 2 was studied by autophosphorylation of the immunoprecipitated kinase.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
3	of	of	ADP	IN	_	_	_	_	_
4	Jak	Jak	PROPN	NNP	Number=Sing	_	_	_	_
5	2	2	NUM	CD	NumType=Card	_	_	_	_
6	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
7	studied	study	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
8	by	by	ADP	IN	_	_	_	_	_
9	autophosphorylation	autophosphorylation	NOUN	NN	Number=Sing	_	_	_	_
10	of	of	ADP	IN	_	_	_	_	_
11	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
12	immunoprecipitated	immunoprecipitate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
13	kinase	kinase	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
14	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2144
# text = Jak 2 was tyrosine phosphorylated within 1 to 3 min after stimulation of eosinophils with IL-5.
1	Jak	Jak	PROPN	NNP	Number=Sing	_	_	_	_
2	2	2	NUM	CD	NumType=Card	_	_	_	_
3	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
4	tyrosine	tyrosine	PRON	PRP	_	_	_	_	_
5	phosphorylated	phosphorylate	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
6	within	within	ADP	IN	_	_	_	_	_
7	1	1	NUM	CD	NumType=Card	_	_	_	_
8	to	to	ADP	IN	_	_	_	_	_
9	3	3	NUM	CD	NumType=Card	_	_	_	_
10	min	min	NOUN	NNS	Number=Plur	_	_	_	_
11	after	after	ADP	IN	_	_	_	_	_
12	stimulation	stimulation	NOUN	NN	Number=Sing	_	_	_	_
13	of	of	ADP	IN	_	_	_	_	_
14	eosinophils	eosinophil	NOUN	NNS	Number=Plur	_	_	_	_
15	with	with	ADP	IN	_	_	_	_	_
16	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
17	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
18	5	5	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
19	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2145
# text = Further, the immunoprecipitated Jak 2 obtained from IL-5-stimulated cells underwent autophosphorylation.
1	Further	further	ADV	RB	_	_	_	_	SpaceAfter=No
2	,	,	PUNCT	,	_	_	_	_	_
3	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
4	immunoprecipitated	immunoprecipitate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
5	Jak	Jak	PROPN	NNP	Number=Sing	_	_	_	_
6	2	2	NUM	CD	NumType=Card	_	_	_	_
7	obtained	obtaine	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
8	from	from	ADP	IN	_	_	_	_	_
9	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
10	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
11	5	5	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
12	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
13	stimulated	stimulate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
14	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
15	underwent	underwent	ADJ	JJ	Degree=Pos	_	_	_	_
16	autophosphorylation	autophosphorylation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
17	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2146
# text = Jak 2 coprecipitated with the beta-subunit of the IL-5 receptor, suggesting a physical association of the kinase with the receptor.
1	Jak	Jak	PROPN	NNP	Number=Sing	_	_	_	_
2	2	2	NUM	CD	NumType=Card	_	_	_	_
3	coprecipitated	coprecipitate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
4	with	with	ADP	IN	_	_	_	_	_
5	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
6	beta	beta	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
7	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
8	subunit	subunit	NOUN	NN	Number=Sing	_	_	_	_
9	of	of	ADP	IN	_	_	_	_	_
10	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
11	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
12	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
13	5	5	NUM	CD	NumType=Card	_	_	_	_
14	receptor	receptor	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
15	,	,	PUNCT	,	_	_	_	_	_
16	suggesting	suggest	VERB	VBG	VerbForm=Ger	_	_	_	_
17	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
18	physical	physical	ADJ	JJ	Degree=Pos	_	_	_	_
19	association	association	NOUN	NN	Number=Sing	_	_	_	_
20	of	of	ADP	IN	_	_	_	_	_
21	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
22	kinase	kinase	NOUN	NN	Number=Sing	_	_	_	_
23	with	with	ADP	IN	_	_	_	_	_
24	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
25	receptor	receptor	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
26	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2147
# text = The nuclear factor STAT-1 (p91) was investigated by immunoprecipitation followed by immunoblotting for tyrosine phosphorylation.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	nuclear	nuclear	ADJ	JJ	Degree=Pos	_	_	_	_
3	factor	factor	NOUN	NN	Number=Sing	_	_	_	_
4	STAT	Stat	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
5	-	-	PUNCT	:	_	_	_	_	SpaceAfter=No
6	1	1	NUM	CD	NumType=Card	_	_	_	_
7	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
8	p91	p91	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
9	)	)	PUNCT	-RRB-	_	_	_	_	_
10	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
11	investigated	investigate	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
12	by	by	ADP	IN	_	_	_	_	_
13	immunoprecipitation	immunoprecipitation	NOUN	NN	Number=Sing	_	_	_	_
14	followed	follow	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
15	by	by	SCONJ	IN	_	_	_	_	_
16	immunoblotting	immunoblott	VERB	VBG	VerbForm=Ger	_	_	_	_
17	for	for	ADP	IN	_	_	_	_	_
18	tyrosine	tyrosine	NOUN	NN	Number=Sing	_	_	_	_
19	phosphorylation	phosphorylation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
20	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2148
# text = STAT-1 was tyrosine phosphorylated within 15 min of IL-5 stimulation.
1	STAT	Stat	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
2	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
3	1	1	NUM	CD	NumType=Card	_	_	_	_
4	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
5	tyrosine	tyrosine	ADV	RB	_	_	_	_	_
6	phosphorylated	phosphorylate	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
7	within	within	ADP	IN	_	_	_	_	_
8	15	15	NUM	CD	NumType=Card	_	_	_	_
9	min	min	NOUN	NNS	Number=Plur	_	_	_	_
10	of	of	ADP	IN	_	_	_	_	_
11	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
12	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
13	5	5	NUM	CD	NumType=Card	_	_	_	_
14	stimulation	stimulation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
15	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2149
# text = The presence of STAT-1 in the nuclear extract was studied by electrophoretic mobility shift assay.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	presence	presence	NOUN	NN	Number=Sing	_	_	_	_
3	of	of	ADP	IN	_	_	_	_	_
4	STAT	STAT	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
5	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
6	1	1	NUM	CD	NumType=Card	_	_	_	_
7	in	in	ADP	IN	_	_	_	_	_
8	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
9	nuclear	nuclear	ADJ	JJ	Degree=Pos	_	_	_	_
10	extract	extract	NOUN	NN	Number=Sing	_	_	_	_
11	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
12	studied	study	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
13	by	by	ADP	IN	_	_	_	_	_
14	electrophoretic	electrophoretic	ADJ	JJ	Degree=Pos	_	_	_	_
15	mobility	mobility	NOUN	NN	Number=Sing	_	_	_	_
16	shift	shift	NOUN	NN	Number=Sing	_	_	_	_
17	assay	assay	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
18	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2150
# text = IL-5 induced two proteins that bound to the gamma-activating sequence.
1	IL	Il	INTJ	UH	_	_	_	_	SpaceAfter=No
2	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
3	5	5	NUM	CD	NumType=Card	_	_	_	_
4	induced	induce	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
5	two	two	NUM	CD	NumType=Card	_	_	_	_
6	proteins	protein	NOUN	NNS	Number=Plur	_	_	_	_
7	that	that	PRON	WDT	PronType=Rel	_	_	_	_
8	bound	bound	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
9	to	to	ADP	IN	_	_	_	_	_
10	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
11	gamma	gamma	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
12	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
13	activating	activating	VERB	VBG	VerbForm=Ger	_	_	_	_
14	sequence	sequence	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
15	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2151
# text = In the presence of an anti-STAT-1
1	In	in	ADP	IN	_	_	_	_	_
2	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
3	presence	presence	NOUN	NN	Number=Sing	_	_	_	_
4	of	of	ADP	IN	_	_	_	_	_
5	an	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
6	anti-STAT	anti-stat	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
7	-1	-1	NUM	CD	NumType=Card	_	_	_	_

# sent_id = 2152
# text = Ab, the band was supershifted.
1	Ab	Ab	ADV	RB	_	_	_	_	SpaceAfter=No
2	,	,	PUNCT	,	_	_	_	_	_
3	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
4	band	band	NOUN	NN	Number=Sing	_	_	_	_
5	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
6	supershifted	supershift	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	SpaceAfter=No
7	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2153
# text = Thus, we demonstrated that IL-5 activated the Jak 2-STAT 1 signaling pathway in eosinophils.
1	Thus	thus	ADV	RB	_	_	_	_	SpaceAfter=No
2	,	,	PUNCT	,	_	_	_	_	_
3	we	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
4	demonstrated	demonstrate	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
5	that	that	SCONJ	IN	_	_	_	_	_
6	IL	Il	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
7	-	-	SYM	SYM	_	_	_	_	SpaceAfter=No
8	5	5	NUM	CD	NumType=Card	_	_	_	_
9	activated	activate	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
10	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
11	Jak	Jak	PROPN	NNP	Number=Sing	_	_	_	_
12	2-	2-	SYM	NFP	_	_	_	_	SpaceAfter=No
13	STAT	Stat	NOUN	NN	Number=Sing	_	_	_	_
14	1	1	NUM	CD	NumType=Card	_	_	_	_
15	signaling	signale	NOUN	NN	Number=Sing	_	_	_	_
16	pathway	pathway	NOUN	NN	Number=Sing	_	_	_	_
17	in	in	ADP	IN	_	_	_	_	_
18	eosinophils	eosinophil	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
19	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2154
# text = We speculate that the Jak 2-STAT 1 pathway may be involved in the activation of IL-5-inducible genes in eosinophils.
1	We	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
2	speculate	speculate	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
3	that	that	SCONJ	IN	_	_	_	_	_
4	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
5	Jak	Jak	PROPN	NNP	Number=Sing	_	_	_	_
6	2-	2-	SYM	NFP	_	_	_	_	SpaceAfter=No
7	STAT	Stat	NOUN	NN	Number=Sing	_	_	_	_
8	1	1	NUM	CD	NumType=Card	_	_	_	_
9	pathway	pathway	NOUN	NN	Number=Sing	_	_	_	_
10	may	may	AUX	MD	VerbForm=Fin	_	_	_	_
11	be	be	AUX	VB	VerbForm=Inf	_	_	_	_
12	involved	involved	ADJ	JJ	Degree=Pos	_	_	_	_
13	in	in	ADP	IN	_	_	_	_	_
14	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
15	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
16	of	of	ADP	IN	_	_	_	_	_
17	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
18	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
19	5	5	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
20	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
21	inducible	inducible	ADJ	JJ	Degree=Pos	_	_	_	_
22	genes	gene	NOUN	NNS	Number=Plur	_	_	_	_
23	in	in	ADP	IN	_	_	_	_	_
24	eosinophils	eosinophil	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
25	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 2155
# text = Document 003003139 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	003003139	003003139	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 2156
# text = Retinoid X receptor (RXR) agonist-induced activation of dominant-negative RXR-retinoic acid receptor alpha403 heterodimers is developmentally regulated during myeloid differentiation.
1	Retinoid	Retinoid	ADJ	JJ	Degree=Pos	_	_	_	_
2	X	x	NOUN	NN	Number=Sing	_	_	_	_
3	receptor	receptor	NOUN	NN	Number=Sing	_	_	_	_
4	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
5	RXR	RXR	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
6	)	)	PUNCT	-RRB-	_	_	_	_	_
7	agonist	agonist	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
8	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
9	induced	induce	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
10	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
11	of	of	ADP	IN	_	_	_	_	_
12	dominant	dominant	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
13	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
14	negative	negative	ADJ	JJ	Degree=Pos	_	_	_	_
15	RXR	Rxr	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
16	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
17	retinoic	retinoic	ADJ	JJ	Degree=Pos	_	_	_	_
18	acid	acid	ADJ	JJ	Degree=Pos	_	_	_	_
19	receptor	receptor	NOUN	NN	Number=Sing	_	_	_	_
20	alpha403	alpha403	NOUN	NN	Number=Sing	_	_	_	_
21	heterodimers	heterodimer	NOUN	NNS	Number=Plur	_	_	_	_
22	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
23	developmentally	developmentally	ADV	RB	_	_	_	_	_
24	regulated	regulate	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
25	during	during	ADP	IN	_	_	_	_	_
26	myeloid	myeloid	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
27	differentiation	differentiation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
28	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 2157
# text = The multiple biologic activities of retinoic acid (RA) are mediated through RAR and retinoid X receptor (RXR) nuclear receptors that interact with specific DNA target sequences as heterodimers (RXR-RAR) or homodimers (RXR-RXR).
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	multiple	multiple	ADJ	JJ	Degree=Pos	_	_	_	_
3	biologic	biologic	NOUN	NN	Number=Sing	_	_	_	_
4	activities	activity	NOUN	NNS	Number=Plur	_	_	_	_
5	of	of	ADP	IN	_	_	_	_	_
6	retinoic	retinoic	ADJ	JJ	Degree=Pos	_	_	_	_
7	acid	acid	NOUN	NN	Number=Sing	_	_	_	_
8	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
9	RA	Ra	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
10	)	)	PUNCT	-RRB-	_	_	_	_	_
11	are	be	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
12	mediated	mediate	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
13	through	through	ADP	IN	_	_	_	_	_
14	RAR	RAR	PROPN	NNP	Number=Sing	_	_	_	_
15	and	and	CCONJ	CC	_	_	_	_	_
16	retinoid	retinoid	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
17	X	x	ADP	IN	_	_	_	_	_
18	receptor	receptor	NOUN	NN	Number=Sing	_	_	_	_
19	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
20	RXR	RXR	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
21	)	)	PUNCT	-RRB-	_	_	_	_	_
22	nuclear	nuclear	ADJ	JJ	Degree=Pos	_	_	_	_
23	receptors	receptor	NOUN	NNS	Number=Plur	_	_	_	_
24	that	that	PRON	WDT	PronType=Rel	_	_	_	_
25	interact	interact	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
26	with	with	ADP	IN	_	_	_	_	_
27	specific	specific	ADJ	JJ	Degree=Pos	_	_	_	_
28	DNA	dna	NOUN	NN	Number=Sing	_	_	_	_
29	target	target	NOUN	NN	Number=Sing	_	_	_	_
30	sequences	sequence	NOUN	NNS	Number=Plur	_	_	_	_
31	as	as	ADP	IN	_	_	_	_	_
32	heterodimers	heterodimer	NOUN	NNS	Number=Plur	_	_	_	_
33	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
34	RXR	Rxr	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
35	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
36	RAR	Rar	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
37	)	)	PUNCT	-RRB-	_	_	_	_	_
38	or	or	CCONJ	CC	_	_	_	_	_
39	homodimers	homodimer	NOUN	NNS	Number=Plur	_	_	_	_
40	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
41	RXR-	RXR-	X	AFX	_	_	_	_	SpaceAfter=No
42	RXR	Rxr	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
43	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
44	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2158
# text = RA receptor activation appears critical to regulating important aspects of hematopoiesis, since transducing a COOH-terminally truncated RARalpha exhibiting dominant-negative activity (RARalpha403) into normal mouse bone marrow generates hematopoietic growth factor-dependent cell lines frozen at the multipotent progenitor (EML) or committed promyelocyte (MPRO) stages.
1	RA	Ra	NOUN	NN	Number=Sing	_	_	_	_
2	receptor	receptor	NOUN	NN	Number=Sing	_	_	_	_
3	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
4	appears	appear	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
5	critical	critical	ADJ	JJ	Degree=Pos	_	_	_	_
6	to	to	SCONJ	IN	_	_	_	_	_
7	regulating	regulate	VERB	VBG	VerbForm=Ger	_	_	_	_
8	important	important	ADJ	JJ	Degree=Pos	_	_	_	_
9	aspects	aspect	NOUN	NNS	Number=Plur	_	_	_	_
10	of	of	ADP	IN	_	_	_	_	_
11	hematopoiesis	hematopoiesis	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
12	,	,	PUNCT	,	_	_	_	_	_
13	since	since	SCONJ	IN	_	_	_	_	_
14	transducing	transduce	VERB	VBG	VerbForm=Ger	_	_	_	_
15	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
16	COOH	COOh	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
17	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
18	terminally	terminally	ADV	RB	_	_	_	_	_
19	truncated	truncate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
20	RARalpha	RARalpha	PROPN	NNP	Number=Sing	_	_	_	_
21	exhibiting	exhibite	VERB	VBG	VerbForm=Ger	_	_	_	_
22	dominant	dominant	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
23	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
24	negative	negative	ADJ	JJ	Degree=Pos	_	_	_	_
25	activity	activity	NOUN	NN	Number=Sing	_	_	_	_
26	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
27	RARalpha403	RARalpha403	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
28	)	)	PUNCT	-RRB-	_	_	_	_	_
29	into	into	ADP	IN	_	_	_	_	_
30	normal	normal	ADJ	JJ	Degree=Pos	_	_	_	_
31	mouse	mouse	NOUN	NN	Number=Sing	_	_	_	_
32	bone	bone	NOUN	NN	Number=Sing	_	_	_	_
33	marrow	marrow	NOUN	NN	Number=Sing	_	_	_	_
34	generates	generate	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
35	hematopoietic	hematopoietic	ADJ	JJ	Degree=Pos	_	_	_	_
36	growth	growth	NOUN	NN	Number=Sing	_	_	_	_
37	factor	factor	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
38	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
39	dependent	dependent	ADJ	JJ	Degree=Pos	_	_	_	_
40	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
41	lines	line	NOUN	NNS	Number=Plur	_	_	_	_
42	frozen	freeze	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
43	at	at	ADP	IN	_	_	_	_	_
44	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
45	multipotent	multipotent	ADJ	JJ	Degree=Pos	_	_	_	_
46	progenitor	progenitor	NOUN	NN	Number=Sing	_	_	_	_
47	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
48	EML	EML	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
49	)	)	PUNCT	-RRB-	_	_	_	_	_
50	or	or	CCONJ	CC	_	_	_	_	_
51	committed	commit	ADJ	JJ	Degree=Pos	_	_	_	_
52	promyelocyte	promyelocyte	NOUN	NN	Number=Sing	_	_	_	_
53	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
54	MPRO	MPRO	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
55	)	)	PUNCT	-RRB-	_	_	_	_	_
56	stages	stage	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
57	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2159
# text = Nevertheless, relatively high, pharmacological concentrations of RA (1 to 10 &mgr;M) overcome these differentiation blocks and induce terminal granulocytic differentiation of the MPRO promyelocytes while potentiating interleukin-3 (IL-3)-induced commitment of EML cells to the granulocyte/monocyte lineage.
1	Nevertheless	nevertheless	ADV	RB	_	_	_	_	SpaceAfter=No
2	,	,	PUNCT	,	_	_	_	_	_
3	relatively	relatively	ADV	RB	_	_	_	_	_
4	high	high	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
5	,	,	PUNCT	,	_	_	_	_	_
6	pharmacological	pharmacological	ADJ	JJ	Degree=Pos	_	_	_	_
7	concentrations	concentration	NOUN	NNS	Number=Plur	_	_	_	_
8	of	of	ADP	IN	_	_	_	_	_
9	RA	RA	PROPN	NNP	Number=Sing	_	_	_	_
10	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
11	1	1	NUM	CD	NumType=Card	_	_	_	_
12	to	to	ADP	IN	_	_	_	_	_
13	10	10	NUM	CD	NumType=Card	_	_	_	_
14	&	&	CCONJ	CC	_	_	_	_	SpaceAfter=No
15	mgr	mgr	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
16	;	;	PUNCT	,	_	_	_	_	SpaceAfter=No
17	M	m	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
18	)	)	PUNCT	-RRB-	_	_	_	_	_
19	overcome	overcome	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
20	these	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
21	differentiation	differentiation	NOUN	NN	Number=Sing	_	_	_	_
22	blocks	block	NOUN	NNS	Number=Plur	_	_	_	_
23	and	and	CCONJ	CC	_	_	_	_	_
24	induce	induce	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
25	terminal	terminal	ADJ	JJ	Degree=Pos	_	_	_	_
26	granulocytic	granulocytic	ADJ	JJ	Degree=Pos	_	_	_	_
27	differentiation	differentiation	NOUN	NN	Number=Sing	_	_	_	_
28	of	of	ADP	IN	_	_	_	_	_
29	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
30	MPRO	MPRO	PROPN	NNP	Number=Sing	_	_	_	_
31	promyelocytes	promyelocyte	NOUN	NNS	Number=Plur	_	_	_	_
32	while	while	SCONJ	IN	_	_	_	_	_
33	potentiating	potentiat	VERB	VBG	VerbForm=Ger	_	_	_	_
34	interleukin	interleukin	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
35	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
36	3	3	NUM	CD	NumType=Card	_	_	_	_
37	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
38	IL	Il	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
39	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
40	3	3	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
41	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
42	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
43	induced	induce	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
44	commitment	commitment	NOUN	NN	Number=Sing	_	_	_	_
45	of	of	ADP	IN	_	_	_	_	_
46	EML	EML	ADJ	JJ	Degree=Pos	_	_	_	_
47	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
48	to	to	ADP	IN	_	_	_	_	_
49	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
50	granulocyte	granulocyte	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
51	/	/	PUNCT	,	_	_	_	_	SpaceAfter=No
52	monocyte	monocyte	NOUN	NN	Number=Sing	_	_	_	_
53	lineage	lineage	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
54	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2160
# text = In the present study, we utilized RXR- and RAR-specific agonists and antagonists to determine how RA overcomes the dominant-negative activity of the truncated RARalpha in these different myeloid developmental stages.
1	In	in	ADP	IN	_	_	_	_	_
2	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
3	present	present	ADJ	JJ	Degree=Pos	_	_	_	_
4	study	study	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
5	,	,	PUNCT	,	_	_	_	_	_
6	we	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
7	utilized	utilize	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
8	RXR	RXR	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
9	-	-	PUNCT	,	_	_	_	_	_
10	and	and	CCONJ	CC	_	_	_	_	_
11	RAR-	RAR-	X	GW	_	_	_	_	SpaceAfter=No
12	specific	specific	ADJ	JJ	Degree=Pos	_	_	_	_
13	agonists	agonist	NOUN	NNS	Number=Plur	_	_	_	_
14	and	and	CCONJ	CC	_	_	_	_	_
15	antagonists	antagonist	NOUN	NNS	Number=Plur	_	_	_	_
16	to	to	PART	TO	_	_	_	_	_
17	determine	determine	VERB	VB	VerbForm=Inf	_	_	_	_
18	how	how	ADV	WRB	PronType=Int	_	_	_	_
19	RA	RA	PROPN	NNP	Number=Sing	_	_	_	_
20	overcomes	overcome	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
21	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
22	dominant	dominant	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
23	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
24	negative	negative	ADJ	JJ	Degree=Pos	_	_	_	_
25	activity	activity	NOUN	NN	Number=Sing	_	_	_	_
26	of	of	ADP	IN	_	_	_	_	_
27	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
28	truncated	truncate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
29	RARalpha	RARalpha	PROPN	NNP	Number=Sing	_	_	_	_
30	in	in	ADP	IN	_	_	_	_	_
31	these	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
32	different	different	ADJ	JJ	Degree=Pos	_	_	_	_
33	myeloid	myeloid	ADJ	JJ	Degree=Pos	_	_	_	_
34	developmental	developmental	ADJ	JJ	Degree=Pos	_	_	_	_
35	stages	stage	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
36	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2161
# text = Unexpectedly, we observed that an RXR-specific, rather than an RAR-specific, agonist induces terminal granulocytic differentiation of MPRO promyelocytes, and this differentiation is associated with activation of DNA response elements corresponding to RAR-RXR heterodimers rather than RXR-RXR homodimers.
1	Unexpectedly	unexpectedly	ADV	RB	_	_	_	_	SpaceAfter=No
2	,	,	PUNCT	,	_	_	_	_	_
3	we	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
4	observed	observe	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
5	that	that	PRON	DT	Number=Sing|PronType=Dem	_	_	_	_
6	an	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
7	RXR-specific	RXR-specific	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
8	,	,	PUNCT	,	_	_	_	_	_
9	rather	rather	ADV	RB	_	_	_	_	_
10	than	than	ADP	IN	_	_	_	_	_
11	an	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
12	RAR-	rar-	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
13	specific	specific	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
14	,	,	PUNCT	,	_	_	_	_	_
15	agonist	agonist	ADJ	JJ	Degree=Pos	_	_	_	_
16	induces	induces	NOUN	NNS	Number=Plur	_	_	_	_
17	terminal	terminal	ADJ	JJ	Degree=Pos	_	_	_	_
18	granulocytic	granulocytic	ADJ	JJ	Degree=Pos	_	_	_	_
19	differentiation	differentiation	NOUN	NN	Number=Sing	_	_	_	_
20	of	of	ADP	IN	_	_	_	_	_
21	MPRO	MPRO	ADJ	JJ	Degree=Pos	_	_	_	_
22	promyelocytes	promyelocyte	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
23	,	,	PUNCT	,	_	_	_	_	_
24	and	and	CCONJ	CC	_	_	_	_	_
25	this	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
26	differentiation	differentiation	NOUN	NN	Number=Sing	_	_	_	_
27	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
28	associated	associate	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
29	with	with	ADP	IN	_	_	_	_	_
30	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
31	of	of	ADP	IN	_	_	_	_	_
32	DNA	dna	NOUN	NN	Number=Sing	_	_	_	_
33	response	response	NOUN	NN	Number=Sing	_	_	_	_
34	elements	element	NOUN	NNS	Number=Plur	_	_	_	_
35	corresponding	correspond	VERB	VBG	VerbForm=Ger	_	_	_	_
36	to	to	ADP	IN	_	_	_	_	_
37	RAR	RAR	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
38	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
39	RXR	RXR	PROPN	NNP	Number=Sing	_	_	_	_
40	heterodimers	heterodimer	NOUN	NNS	Number=Plur	_	_	_	_
41	rather	rather	ADV	RB	_	_	_	_	_
42	than	than	ADP	IN	_	_	_	_	_
43	RXR	RXR	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
44	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
45	RXR	RXR	PROPN	NNP	Number=Sing	_	_	_	_
46	homodimers	homodimer	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
47	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2162
# text = This RXR agonist activity is blocked by RAR-specific antagonists, suggesting extensive cross-talk between the partners of the RXR -RARalpha403 heterodimer.
1	This	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
2	RXR	Rxr	NOUN	NN	Number=Sing	_	_	_	_
3	agonist	agonist	NOUN	NN	Number=Sing	_	_	_	_
4	activity	activity	NOUN	NN	Number=Sing	_	_	_	_
5	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
6	blocked	block	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
7	by	by	ADP	IN	_	_	_	_	_
8	RAR-	RAR-	X	AFX	_	_	_	_	SpaceAfter=No
9	specific	specific	ADJ	JJ	Degree=Pos	_	_	_	_
10	antagonists	antagonist	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
11	,	,	PUNCT	,	_	_	_	_	_
12	suggesting	suggest	VERB	VBG	VerbForm=Ger	_	_	_	_
13	extensive	extensive	ADJ	JJ	Degree=Pos	_	_	_	_
14	cross-talk	cross-talk	NOUN	NN	Number=Sing	_	_	_	_
15	between	between	ADP	IN	_	_	_	_	_
16	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
17	partners	partner	NOUN	NNS	Number=Plur	_	_	_	_
18	of	of	ADP	IN	_	_	_	_	_
19	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
20	RXR	Rxr	PROPN	NNP	Number=Sing	_	_	_	_
21	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
22	RARalpha403	RARalpha403	NUM	CD	NumType=Card	_	_	_	_
23	heterodimer	heterodimer	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
24	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2163
# text = In contrast, in the more immature, multipotent EML cells we observed that this RXR-specific agonist is inactive either in potentiating IL-3-mediated commitment of EML cells to the granulocyte lineage or in transactivating RAR-RXR response elements.
1	In	in	ADP	IN	_	_	_	_	_
2	contrast	contrast	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
3	,	,	PUNCT	,	_	_	_	_	_
4	in	in	ADP	IN	_	_	_	_	_
5	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
6	more	more	ADV	RBR	_	_	_	_	_
7	immature	immature	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
8	,	,	PUNCT	,	_	_	_	_	_
9	multipotent	multipotent	ADJ	JJ	Degree=Pos	_	_	_	_
10	EML	EML	ADJ	JJ	Degree=Pos	_	_	_	_
11	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
12	we	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
13	observed	observe	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
14	that	that	SCONJ	IN	_	_	_	_	_
15	this	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
16	RXR-	rxr-	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
17	specific	specific	ADJ	JJ	Degree=Pos	_	_	_	_
18	agonist	agonist	NOUN	NN	Number=Sing	_	_	_	_
19	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
20	inactive	inactive	ADJ	JJ	Degree=Pos	_	_	_	_
21	either	either	CCONJ	CC	_	_	_	_	_
22	in	in	SCONJ	IN	_	_	_	_	_
23	potentiating	potentiat	VERB	VBG	VerbForm=Ger	_	_	_	_
24	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
25	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
26	3	3	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
27	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
28	mediated	mediate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
29	commitment	commitment	NOUN	NN	Number=Sing	_	_	_	_
30	of	of	ADP	IN	_	_	_	_	_
31	EML	EML	ADJ	JJ	Degree=Pos	_	_	_	_
32	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
33	to	to	ADP	IN	_	_	_	_	_
34	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
35	granulocyte	granulocyte	NOUN	NN	Number=Sing	_	_	_	_
36	lineage	lineage	NOUN	NN	Number=Sing	_	_	_	_
37	or	or	CCONJ	CC	_	_	_	_	_
38	in	in	SCONJ	IN	_	_	_	_	_
39	transactivating	transactivat	VERB	VBG	VerbForm=Ger	_	_	_	_
40	RAR	RAR	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
41	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
42	RXR	RXR	PROPN	NNP	Number=Sing	_	_	_	_
43	response	response	NOUN	NN	Number=Sing	_	_	_	_
44	elements	element	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
45	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2164
# text = RA- triggered GALdbd-RARalpha hybrid activity in these cells indicates that the multipotent EML cells harbor substantial nuclear hormone receptor coactivator activity.
1	RA	Ra	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
2	-	-	PUNCT	HYPH	_	_	_	_	_
3	triggered	trigger	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
4	GALdbd	GALdbd	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
5	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
6	RARalpha	RARalpha	PROPN	NNP	Number=Sing	_	_	_	_
7	hybrid	hybrid	NOUN	NN	Number=Sing	_	_	_	_
8	activity	activity	NOUN	NN	Number=Sing	_	_	_	_
9	in	in	ADP	IN	_	_	_	_	_
10	these	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
11	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
12	indicates	indicate	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
13	that	that	SCONJ	IN	_	_	_	_	_
14	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
15	multipotent	multipotent	ADJ	JJ	Degree=Pos	_	_	_	_
16	EML	eml	ADJ	JJ	Degree=Pos	_	_	_	_
17	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
18	harbor	harbor	CCONJ	CC	_	_	_	_	_
19	substantial	substantial	ADJ	JJ	Degree=Pos	_	_	_	_
20	nuclear	nuclear	ADJ	JJ	Degree=Pos	_	_	_	_
21	hormone	hormone	NOUN	NN	Number=Sing	_	_	_	_
22	receptor	receptor	NOUN	NN	Number=Sing	_	_	_	_
23	coactivator	coactivator	NOUN	NN	Number=Sing	_	_	_	_
24	activity	activity	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
25	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2165
# text = However, the histone deacetylase (HDAC) inhibitor trichostatin
1	However	however	ADV	RB	_	_	_	_	SpaceAfter=No
2	,	,	PUNCT	,	_	_	_	_	_
3	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
4	histone	histone	NOUN	NN	Number=Sing	_	_	_	_
5	deacetylase	deacetylase	NOUN	NN	Number=Sing	_	_	_	_
6	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
7	HDAC	HDAC	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
8	)	)	PUNCT	-RRB-	_	_	_	_	_
9	inhibitor	inhibitor	NOUN	NN	Number=Sing	_	_	_	_
10	trichostatin	trichostatin	NOUN	NN	Number=Sing	_	_	_	_

# sent_id = 2166
# text = A readily activates an RXR-RAR reporter construct in the multipotent EML cells but not in the committed MPRO promyelocytes, indicating that differences in HDAC-containing repressor complexes in these two closely related but distinct hematopoietic lineages might account for the differential activation of the RXR-RARalpha403 heterodimers that we observed at these different stages of myeloid development.
1	A	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
2	readily	readily	NOUN	NN	Number=Sing	_	_	_	_
3	activates	activate	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
4	an	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
5	RXR	RXR	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
6	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
7	RAR	RAR	PROPN	NNP	Number=Sing	_	_	_	_
8	reporter	reporter	NOUN	NN	Number=Sing	_	_	_	_
9	construct	construct	NOUN	NN	Number=Sing	_	_	_	_
10	in	in	ADP	IN	_	_	_	_	_
11	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
12	multipotent	multipotent	ADJ	JJ	Degree=Pos	_	_	_	_
13	EML	EML	ADJ	JJ	Degree=Pos	_	_	_	_
14	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
15	but	but	CCONJ	CC	_	_	_	_	_
16	not	not	PART	RB	_	_	_	_	_
17	in	in	ADP	IN	_	_	_	_	_
18	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
19	committed	committed	ADJ	JJ	Degree=Pos	_	_	_	_
20	MPRO	Mpro	NOUN	NN	Number=Sing	_	_	_	_
21	promyelocytes	promyelocyte	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
22	,	,	PUNCT	,	_	_	_	_	_
23	indicating	indicate	VERB	VBG	VerbForm=Ger	_	_	_	_
24	that	that	SCONJ	IN	_	_	_	_	_
25	differences	difference	NOUN	NNS	Number=Plur	_	_	_	_
26	in	in	ADP	IN	_	_	_	_	_
27	HDAC	HDAC	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
28	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
29	containing	contain	VERB	VBG	VerbForm=Ger	_	_	_	_
30	repressor	repressor	NOUN	NN	Number=Sing	_	_	_	_
31	complexes	complex	NOUN	NNS	Number=Plur	_	_	_	_
32	in	in	ADP	IN	_	_	_	_	_
33	these	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
34	two	two	NUM	CD	NumType=Card	_	_	_	_
35	closely	closely	ADV	RB	_	_	_	_	_
36	related	related	ADJ	JJ	Degree=Pos	_	_	_	_
37	but	but	CCONJ	CC	_	_	_	_	_
38	distinct	distinct	ADJ	JJ	Degree=Pos	_	_	_	_
39	hematopoietic	hematopoietic	ADJ	JJ	Degree=Pos	_	_	_	_
40	lineages	lineage	NOUN	NNS	Number=Plur	_	_	_	_
41	might	might	AUX	MD	VerbForm=Fin	_	_	_	_
42	account	account	VERB	VB	VerbForm=Inf	_	_	_	_
43	for	for	ADP	IN	_	_	_	_	_
44	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
45	differential	differential	ADJ	JJ	Degree=Pos	_	_	_	_
46	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
47	of	of	ADP	IN	_	_	_	_	_
48	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
49	RXR-	rxr-	SYM	SYM	_	_	_	_	SpaceAfter=No
50	RARalpha403	RARalpha403	NUM	CD	NumType=Card	_	_	_	_
51	heterodimers	heterodimer	NOUN	NNS	Number=Plur	_	_	_	_
52	that	that	PRON	WDT	PronType=Rel	_	_	_	_
53	we	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
54	observed	observe	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
55	at	at	ADP	IN	_	_	_	_	_
56	these	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
57	different	different	ADJ	JJ	Degree=Pos	_	_	_	_
58	stages	stage	NOUN	NNS	Number=Plur	_	_	_	_
59	of	of	ADP	IN	_	_	_	_	_
60	myeloid	myeloid	ADJ	JJ	Degree=Pos	_	_	_	_
61	development	development	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
62	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 2167
# text = Document 003003143 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	003003143	003003143	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 2168
# text = Decreased concentration of 1,25-dihydroxyvitamin D3 receptors in peripheral mononuclear cells of patients with X-linked hypophosphatemic rickets: effect of phosphate supplementation.
1	Decreased	Decrease	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
2	concentration	concentration	NOUN	NN	Number=Sing	_	_	_	_
3	of	of	ADP	IN	_	_	_	_	_
4	1,25	1,25	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
5	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
6	dihydroxyvitamin	dihydroxyvitamin	NOUN	NN	Number=Sing	_	_	_	_
7	D3	D3	NOUN	NN	Number=Sing	_	_	_	_
8	receptors	receptor	NOUN	NNS	Number=Plur	_	_	_	_
9	in	in	ADP	IN	_	_	_	_	_
10	peripheral	peripheral	ADJ	JJ	Degree=Pos	_	_	_	_
11	mononuclear	mononuclear	ADJ	JJ	Degree=Pos	_	_	_	_
12	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
13	of	of	ADP	IN	_	_	_	_	_
14	patients	patient	NOUN	NNS	Number=Plur	_	_	_	_
15	with	with	ADP	IN	_	_	_	_	_
16	X	X	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
17	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
18	linked	link	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
19	hypophosphatemic	hypophosphatemic	ADJ	JJ	Degree=Pos	_	_	_	_
20	rickets	ricket	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
21	:	:	PUNCT	:	_	_	_	_	_
22	effect	effect	NOUN	NN	Number=Sing	_	_	_	_
23	of	of	ADP	IN	_	_	_	_	_
24	phosphate	phosphate	ADJ	JJ	Degree=Pos	_	_	_	_
25	supplementation	supplementation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
26	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 2169
# text = Abnormal renal tubular phosphate transport is considered to be the primary defect in X-linked hypophosphatemic rickets (XLH).
1	Abnormal	abnormal	ADJ	JJ	Degree=Pos	_	_	_	_
2	renal	renal	ADJ	JJ	Degree=Pos	_	_	_	_
3	tubular	tubular	NOUN	NN	Number=Sing	_	_	_	_
4	phosphate	phosphate	NOUN	NN	Number=Sing	_	_	_	_
5	transport	transport	NOUN	NN	Number=Sing	_	_	_	_
6	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
7	considered	consider	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
8	to	to	PART	TO	_	_	_	_	_
9	be	be	AUX	VB	VerbForm=Inf	_	_	_	_
10	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
11	primary	primary	ADJ	JJ	Degree=Pos	_	_	_	_
12	defect	defect	NOUN	NN	Number=Sing	_	_	_	_
13	in	in	ADP	IN	_	_	_	_	_
14	X	X	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
15	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
16	linked	link	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
17	hypophosphatemic	hypophosphatemic	ADJ	JJ	Degree=Pos	_	_	_	_
18	rickets	ricket	NOUN	NNS	Number=Plur	_	_	_	_
19	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
20	XLH	XLH	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
21	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
22	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2170
# text = However, the resistance to vitamin D treatment in XLH cannot be explained by hypophosphatemia alone.
1	However	however	ADV	RB	_	_	_	_	SpaceAfter=No
2	,	,	PUNCT	,	_	_	_	_	_
3	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
4	resistance	resistance	NOUN	NN	Number=Sing	_	_	_	_
5	to	to	PART	TO	_	_	_	_	_
6	vitamin	vitamin	VERB	VB	VerbForm=Inf	_	_	_	_
7	D	would	NOUN	NN	Number=Sing	_	_	_	_
8	treatment	treatment	NOUN	NN	Number=Sing	_	_	_	_
9	in	in	ADP	IN	_	_	_	_	_
10	XLH	XLH	PROPN	NNP	Number=Sing	_	_	_	_
11	can	can	AUX	MD	VerbForm=Fin	_	_	_	SpaceAfter=No
12	not	not	PART	RB	_	_	_	_	_
13	be	be	AUX	VB	VerbForm=Inf	_	_	_	_
14	explained	explain	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
15	by	by	ADP	IN	_	_	_	_	_
16	hypophosphatemia	hypophosphatemia	NOUN	NN	Number=Sing	_	_	_	_
17	alone	alone	ADV	RB	_	_	_	_	SpaceAfter=No
18	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2171
# text = Since most of the actions of vitamin D are mediated by its receptors (VDR), abnormalities of VDR have been postulated in XLH.
1	Since	since	SCONJ	IN	_	_	_	_	_
2	most	most	ADJ	JJS	Degree=Sup	_	_	_	_
3	of	of	ADP	IN	_	_	_	_	_
4	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
5	actions	action	NOUN	NNS	Number=Plur	_	_	_	_
6	of	of	ADP	IN	_	_	_	_	_
7	vitamin	vitamin	NOUN	NN	Number=Sing	_	_	_	_
8	D	d	NOUN	NN	Number=Sing	_	_	_	_
9	are	be	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
10	mediated	mediate	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
11	by	by	ADP	IN	_	_	_	_	_
12	its	its	PRON	PRP$	Gender=Neut|Number=Sing|Person=3|Poss=Yes|PronType=Prs	_	_	_	_
13	receptors	receptor	NOUN	NNS	Number=Plur	_	_	_	_
14	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
15	VDR	VDR	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
16	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
17	,	,	PUNCT	,	_	_	_	_	_
18	abnormalities	abnormality	NOUN	NNS	Number=Plur	_	_	_	_
19	of	of	ADP	IN	_	_	_	_	_
20	VDR	Vdr	PROPN	NNP	Number=Sing	_	_	_	_
21	have	have	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
22	been	be	AUX	VBN	Tense=Past|VerbForm=Part	_	_	_	_
23	postulated	postulate	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
24	in	in	ADP	IN	_	_	_	_	_
25	XLH	XLH	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
26	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2172
# text = In order to investigate this possibility, we measured the concentration of VDR in PHA-activated peripheral mononuclear cells from 10 XLH patients.
1	In	in	ADP	IN	_	_	_	_	_
2	order	order	NOUN	NN	Number=Sing	_	_	_	_
3	to	to	PART	TO	_	_	_	_	_
4	investigate	investigate	VERB	VB	VerbForm=Inf	_	_	_	_
5	this	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
6	possibility	possibility	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
7	,	,	PUNCT	,	_	_	_	_	_
8	we	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
9	measured	measure	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
10	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
11	concentration	concentration	NOUN	NN	Number=Sing	_	_	_	_
12	of	of	ADP	IN	_	_	_	_	_
13	VDR	VDR	PROPN	NNP	Number=Sing	_	_	_	_
14	in	in	ADP	IN	_	_	_	_	_
15	PHA	PHA	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
16	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
17	activated	activate	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
18	peripheral	peripheral	ADJ	JJ	Degree=Pos	_	_	_	_
19	mononuclear	mononuclear	ADJ	JJ	Degree=Pos	_	_	_	_
20	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
21	from	from	ADP	IN	_	_	_	_	_
22	10	10	NUM	CD	NumType=Card	_	_	_	_
23	XLH	Xlh	ADJ	JJ	Degree=Pos	_	_	_	_
24	patients	patient	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
25	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2173
# text = Patients without phosphate supplementation showed significantly lower concentration (21.7 +/- 5.1 fmol/mg protein, mean +/- SEM) compared to the normal controls (60.7 +/- 4.0).
1	Patients	patient	NOUN	NNS	Number=Plur	_	_	_	_
2	without	without	ADP	IN	_	_	_	_	_
3	phosphate	phosphate	NOUN	NN	Number=Sing	_	_	_	_
4	supplementation	supplementation	NOUN	NN	Number=Sing	_	_	_	_
5	showed	show	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
6	significantly	significantly	ADV	RB	_	_	_	_	_
7	lower	lower	ADJ	JJR	Degree=Cmp	_	_	_	_
8	concentration	concentration	NOUN	NN	Number=Sing	_	_	_	_
9	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
10	21.7	21.7	NUM	CD	NumType=Card	_	_	_	_
11	+/-	+/-	SYM	SYM	_	_	_	_	_
12	5.1	5.1	NUM	CD	NumType=Card	_	_	_	_
13	fmol	fmol	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
14	/	/	PUNCT	,	_	_	_	_	SpaceAfter=No
15	mg	mg	NOUN	NN	Number=Sing	_	_	_	_
16	protein	protein	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
17	,	,	PUNCT	,	_	_	_	_	_
18	mean	mean	X	GW	_	_	_	_	_
19	+/-	+/-	X	GW	_	_	_	_	_
20	SEM	SEM	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
21	)	)	PUNCT	-RRB-	_	_	_	_	_
22	compared	compare	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
23	to	to	ADP	IN	_	_	_	_	_
24	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
25	normal	normal	ADJ	JJ	Degree=Pos	_	_	_	_
26	controls	controls	NOUN	NNS	Number=Plur	_	_	_	_
27	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
28	60.7	60.7	NUM	CD	NumType=Card	_	_	_	_
29	+/-	+/-	SYM	SYM	_	_	_	_	_
30	4.0	4.0	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
31	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
32	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2174
# text = On the contrary, there was no significant difference between the phosphate-supplemented patients (58.3 +/- 2.7) and controls.
1	On	on	ADP	IN	_	_	_	_	_
2	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
3	contrary	contrary	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
4	,	,	PUNCT	,	_	_	_	_	_
5	there	there	PRON	EX	_	_	_	_	_
6	was	be	VERB	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
7	no	no	DET	DT	_	_	_	_	_
8	significant	significant	ADJ	JJ	Degree=Pos	_	_	_	_
9	difference	difference	NOUN	NN	Number=Sing	_	_	_	_
10	between	between	ADP	IN	_	_	_	_	_
11	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
12	phosphate	phosphate	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
13	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
14	supplemented	supplement	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
15	patients	patient	NOUN	NNS	Number=Plur	_	_	_	_
16	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
17	58.3	58.3	NUM	CD	NumType=Card	_	_	_	_
18	+/-	+/-	SYM	SYM	_	_	_	_	_
19	2.7	2.7	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
20	)	)	PUNCT	-RRB-	_	_	_	_	_
21	and	and	CCONJ	CC	_	_	_	_	_
22	controls	control	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
23	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2175
# text = There was a significant positive correlation between VDR concentration and serum phosphate (P less than 0.05).
1	There	there	PRON	EX	_	_	_	_	_
2	was	be	VERB	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
3	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
4	significant	significant	ADJ	JJ	Degree=Pos	_	_	_	_
5	positive	positive	ADJ	JJ	Degree=Pos	_	_	_	_
6	correlation	correlation	NOUN	NN	Number=Sing	_	_	_	_
7	between	between	ADP	IN	_	_	_	_	_
8	VDR	Vdr	ADJ	JJ	Degree=Pos	_	_	_	_
9	concentration	concentration	NOUN	NN	Number=Sing	_	_	_	_
10	and	and	CCONJ	CC	_	_	_	_	_
11	serum	serum	NOUN	NN	Number=Sing	_	_	_	_
12	phosphate	phosphate	NOUN	NN	Number=Sing	_	_	_	_
13	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
14	P	p	SYM	NFP	_	_	_	_	_
15	less	less	ADJ	JJR	Degree=Cmp	_	_	_	_
16	than	than	ADP	IN	_	_	_	_	_
17	0.05	0.05	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
18	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
19	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2176
# text = In two patients, VDR was increased after daily phosphate supplementation was started.
1	In	in	ADP	IN	_	_	_	_	_
2	two	two	NUM	CD	NumType=Card	_	_	_	_
3	patients	patient	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
4	,	,	PUNCT	,	_	_	_	_	_
5	VDR	VDR	PROPN	NNP	Number=Sing	_	_	_	_
6	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
7	increased	increase	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
8	after	after	ADP	IN	_	_	_	_	_
9	daily	daily	ADJ	JJ	Degree=Pos	_	_	_	_
10	phosphate	phosphate	NOUN	NN	Number=Sing	_	_	_	_
11	supplementation	supplementation	NOUN	NN	Number=Sing	_	_	_	_
12	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
13	started	start	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	SpaceAfter=No
14	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2177
# text = These results indicate that a decreased concentration of VDR secondary to persistent hypophosphatemia is one of the causes of vitamin D resistance in XLH.
1	These	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
2	results	result	NOUN	NNS	Number=Plur	_	_	_	_
3	indicate	indicate	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
4	that	that	SCONJ	IN	_	_	_	_	_
5	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
6	decreased	decreased	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
7	concentration	concentration	NOUN	NN	Number=Sing	_	_	_	_
8	of	of	ADP	IN	_	_	_	_	_
9	VDR	VDR	PROPN	NNP	Number=Sing	_	_	_	_
10	secondary	secondary	ADJ	JJ	Degree=Pos	_	_	_	_
11	to	to	ADP	IN	_	_	_	_	_
12	persistent	persistent	ADJ	JJ	Degree=Pos	_	_	_	_
13	hypophosphatemia	hypophosphatemia	NOUN	NN	Number=Sing	_	_	_	_
14	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
15	one	one	NUM	CD	NumType=Card	_	_	_	_
16	of	of	ADP	IN	_	_	_	_	_
17	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
18	causes	cause	NOUN	NNS	Number=Plur	_	_	_	_
19	of	of	ADP	IN	_	_	_	_	_
20	vitamin	vitamin	ADJ	JJ	Degree=Pos	_	_	_	_
21	D	d	NOUN	NN	Number=Sing	_	_	_	_
22	resistance	resistance	NOUN	NN	Number=Sing	_	_	_	_
23	in	in	ADP	IN	_	_	_	_	_
24	XLH	XLH	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
25	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 2178
# text = Document 003003144 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	003003144	003003144	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 2179
# text = Spi-C, a novel Ets protein that is temporally regulated during B lymphocyte development.
1	Spi	Spi	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
2	-C	-C	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
3	,	,	PUNCT	,	_	_	_	_	_
4	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
5	novel	novel	NOUN	NN	Number=Sing	_	_	_	_
6	Ets	Ets	NOUN	NN	Number=Sing	_	_	_	_
7	protein	protein	NOUN	NN	Number=Sing	_	_	_	_
8	that	that	PRON	WDT	PronType=Rel	_	_	_	_
9	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
10	temporally	temporally	ADV	RB	_	_	_	_	_
11	regulated	regulate	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
12	during	during	ADP	IN	_	_	_	_	_
13	B	b	NOUN	NN	Number=Sing	_	_	_	_
14	lymphocyte	lymphocyte	NOUN	NN	Number=Sing	_	_	_	_
15	development	development	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
16	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 2180
# text = A novel Ets protein was isolated by yeast one-hybrid screening of a cDNA library made from lipopolysaccharide-stimulated mouse splenic
1	A	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
2	novel	novel	ADJ	JJ	Degree=Pos	_	_	_	_
3	Ets	Ets	NOUN	NNS	Number=Plur	_	_	_	_
4	protein	protein	NOUN	NN	Number=Sing	_	_	_	_
5	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
6	isolated	isolate	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
7	by	by	ADP	IN	_	_	_	_	_
8	yeast	yeast	ADJ	JJS	Degree=Sup	_	_	_	_
9	one	one	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
10	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
11	hybrid	hybrid	NOUN	NN	Number=Sing	_	_	_	_
12	screening	screening	NOUN	NN	Number=Sing	_	_	_	_
13	of	of	ADP	IN	_	_	_	_	_
14	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
15	cDNA	cDNa	NOUN	NN	Number=Sing	_	_	_	_
16	library	library	NOUN	NN	Number=Sing	_	_	_	_
17	made	make	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
18	from	from	ADP	IN	_	_	_	_	_
19	lipopolysaccharide	lipopolysaccharide	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
20	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
21	stimulated	stimulate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
22	mouse	mouse	NOUN	NN	Number=Sing	_	_	_	_
23	splenic	splenic	NOUN	NN	Number=Sing	_	_	_	_

# sent_id = 2181
# text = B cells, using the SP6 kappa promoter kappaY element as a bait.
1	B	b	ADJ	JJ	Degree=Pos	_	_	_	_
2	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
3	,	,	PUNCT	,	_	_	_	_	_
4	using	use	VERB	VBG	VerbForm=Ger	_	_	_	_
5	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
6	SP6	Sp6	PROPN	NNP	Number=Sing	_	_	_	_
7	kappa	kappa	PROPN	NNP	Number=Sing	_	_	_	_
8	promoter	promoter	NOUN	NN	Number=Sing	_	_	_	_
9	kappaY	kappay	NOUN	NN	Number=Sing	_	_	_	_
10	element	element	NOUN	NN	Number=Sing	_	_	_	_
11	as	as	ADP	IN	_	_	_	_	_
12	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
13	bait	bait	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
14	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2182
# text = The novel Ets protein was most closely related to PU.1 and Spi-B within the DNA binding Ets domain and was therefore named Spi-C.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	novel	novel	NOUN	NN	Number=Sing	_	_	_	_
3	Ets	Ets	PROPN	NNPS	Number=Plur	_	_	_	_
4	protein	protein	PROPN	NNP	Number=Sing	_	_	_	_
5	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
6	most	most	ADV	RBS	_	_	_	_	_
7	closely	closely	ADV	RB	_	_	_	_	_
8	related	related	ADJ	JJ	Degree=Pos	_	_	_	_
9	to	to	ADP	IN	_	_	_	_	_
10	PU.1	PU.1	PROPN	NNP	Number=Sing	_	_	_	_
11	and	and	CCONJ	CC	_	_	_	_	_
12	Spi	Spi	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
13	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
14	B	B	PROPN	NNP	Number=Sing	_	_	_	_
15	within	within	ADP	IN	_	_	_	_	_
16	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
17	DNA	dna	NOUN	NN	Number=Sing	_	_	_	_
18	binding	bind	VERB	VBG	VerbForm=Ger	_	_	_	_
19	Ets	et	NOUN	NNS	Number=Plur	_	_	_	_
20	domain	domain	NOUN	NN	Number=Sing	_	_	_	_
21	and	and	CCONJ	CC	_	_	_	_	_
22	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
23	therefore	therefore	ADV	RB	_	_	_	_	_
24	named	name	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
25	Spi	Spi	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
26	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
27	C	C	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
28	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2183
# text = However, Spi-C may represent a novel subgroup within the Ets protein family, as it differed significantly from Spi-B and PU.1 within helix 1 of the Ets domain.
1	However	however	ADV	RB	_	_	_	_	SpaceAfter=No
2	,	,	PUNCT	,	_	_	_	_	_
3	Spi	Spi	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
4	-C	-C	PROPN	NNP	Number=Sing	_	_	_	_
5	may	may	AUX	MD	VerbForm=Fin	_	_	_	_
6	represent	represent	VERB	VB	VerbForm=Inf	_	_	_	_
7	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
8	novel	novel	NOUN	NN	Number=Sing	_	_	_	_
9	subgroup	subgroup	NOUN	NN	Number=Sing	_	_	_	_
10	within	within	ADP	IN	_	_	_	_	_
11	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
12	Ets	ets	PROPN	NNPS	Number=Plur	_	_	_	_
13	protein	protein	NOUN	NN	Number=Sing	_	_	_	_
14	family	family	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
15	,	,	PUNCT	,	_	_	_	_	_
16	as	as	SCONJ	IN	_	_	_	_	_
17	it	it	PRON	PRP	Case=Nom|Gender=Neut|Number=Sing|Person=3|PronType=Prs	_	_	_	_
18	differed	differ	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
19	significantly	significantly	ADV	RB	_	_	_	_	_
20	from	from	ADP	IN	_	_	_	_	_
21	Spi	Spi	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
22	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
23	B	B	PROPN	NNP	Number=Sing	_	_	_	_
24	and	and	CCONJ	CC	_	_	_	_	_
25	PU.1	PU.1	NUM	CD	NumType=Card	_	_	_	_
26	within	within	ADP	IN	_	_	_	_	_
27	helix	helix	NUM	CD	NumType=Card	_	_	_	_
28	1	1	NUM	CD	NumType=Card	_	_	_	_
29	of	of	ADP	IN	_	_	_	_	_
30	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
31	Ets	ets	PROPN	NNPS	Number=Plur	_	_	_	_
32	domain	domain	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
33	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2184
# text = Spi-C was encoded by a single-copy gene that was mapped to chromosome 10, region C. Spi-C interacted with DNA similarly to PU.1 as judged by methylation interference, band-shift and site selection analysis, and activated transcription of a kappaY element reporter gene upon co-transfection of HeLa cells.
1	Spi	Spi	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
2	-C	-C	PROPN	NNP	Number=Sing	_	_	_	_
3	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
4	encoded	encod	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
5	by	by	ADP	IN	_	_	_	_	_
6	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
7	single	single	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
8	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
9	copy	copy	NOUN	NN	Number=Sing	_	_	_	_
10	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
11	that	that	PRON	WDT	PronType=Rel	_	_	_	_
12	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
13	mapped	map	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
14	to	to	PART	TO	_	_	_	_	_
15	chromosome	chromosome	VERB	VB	VerbForm=Inf	_	_	_	_
16	10	10	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
17	,	,	PUNCT	,	_	_	_	_	_
18	region	region	NOUN	NN	Number=Sing	_	_	_	_
19	C	C	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
20	.	.	PUNCT	.	_	_	_	_	_
21	Spi	Spi	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
22	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
23	C	C	PROPN	NNP	Number=Sing	_	_	_	_
24	interacted	interact	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
25	with	with	ADP	IN	_	_	_	_	_
26	DNA	dna	NOUN	NN	Number=Sing	_	_	_	_
27	similarly	similarly	ADV	RB	_	_	_	_	_
28	to	to	ADP	IN	_	_	_	_	_
29	PU.1	PU.1	PROPN	NNP	Number=Sing	_	_	_	_
30	as	as	SCONJ	IN	_	_	_	_	_
31	judged	judge	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
32	by	by	ADP	IN	_	_	_	_	_
33	methylation	methylation	NOUN	NN	Number=Sing	_	_	_	_
34	interference	interference	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
35	,	,	PUNCT	,	_	_	_	_	_
36	band	band	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
37	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
38	shift	shift	NOUN	NN	Number=Sing	_	_	_	_
39	and	and	CCONJ	CC	_	_	_	_	_
40	site	site	NOUN	NN	Number=Sing	_	_	_	_
41	selection	selection	NOUN	NN	Number=Sing	_	_	_	_
42	analysis	analysis	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
43	,	,	PUNCT	,	_	_	_	_	_
44	and	and	CCONJ	CC	_	_	_	_	_
45	activated	activate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
46	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
47	of	of	ADP	IN	_	_	_	_	_
48	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
49	kappaY	kappaY	PROPN	NNP	Number=Sing	_	_	_	_
50	element	element	NOUN	NN	Number=Sing	_	_	_	_
51	reporter	reporter	NOUN	NN	Number=Sing	_	_	_	_
52	gene	gene	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
53	upon	upon	ADP	IN	_	_	_	_	_
54	co-transfection	co-transfection	NOUN	NN	Number=Sing	_	_	_	_
55	of	of	ADP	IN	_	_	_	_	_
56	HeLa	HeLa	PROPN	NNP	Number=Sing	_	_	_	_
57	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
58	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2185
# text = Spi-C RNA was expressed in mature B lymphocytes and at lower levels in macrophages.
1	Spi	Spi	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
2	-C	-C	PROPN	NNP	Number=Sing	_	_	_	_
3	RNA	RNA	PROPN	NNP	Number=Sing	_	_	_	_
4	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
5	expressed	express	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
6	in	in	ADP	IN	_	_	_	_	_
7	mature	mature	ADJ	JJ	Degree=Pos	_	_	_	_
8	B	b	NOUN	NN	Number=Sing	_	_	_	_
9	lymphocytes	lymphocyte	NOUN	NNS	Number=Plur	_	_	_	_
10	and	and	CCONJ	CC	_	_	_	_	_
11	at	at	ADP	IN	_	_	_	_	_
12	lower	lower	ADJ	JJR	Degree=Cmp	_	_	_	_
13	levels	level	NOUN	NNS	Number=Plur	_	_	_	_
14	in	in	ADP	IN	_	_	_	_	_
15	macrophages	macrophage	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
16	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2186
# text = Furthermore, pre-B cell and plasma cell lines were Spi-C-negative, suggesting that Spi-C might be a regulatory molecule during a specific phase of B lymphoid development.
1	Furthermore	furthermore	ADV	RB	_	_	_	_	SpaceAfter=No
2	,	,	PUNCT	,	_	_	_	_	_
3	pre	pre	X	AFX	_	_	_	_	SpaceAfter=No
4	-B	-b	ADJ	JJ	Degree=Pos	_	_	_	_
5	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
6	and	and	CCONJ	CC	_	_	_	_	_
7	plasma	plasma	NOUN	NN	Number=Sing	_	_	_	_
8	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
9	lines	line	NOUN	NNS	Number=Plur	_	_	_	_
10	were	be	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
11	Spi	Spi	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
12	-C-	-C-	SYM	NFP	_	_	_	_	SpaceAfter=No
13	negative	negative	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
14	,	,	PUNCT	,	_	_	_	_	_
15	suggesting	suggest	VERB	VBG	VerbForm=Ger	_	_	_	_
16	that	that	SCONJ	IN	_	_	_	_	_
17	Spi	Spi	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
18	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
19	C	C	PROPN	NNP	Number=Sing	_	_	_	_
20	might	might	AUX	MD	VerbForm=Fin	_	_	_	_
21	be	be	AUX	VB	VerbForm=Inf	_	_	_	_
22	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
23	regulatory	regulatory	ADJ	JJ	Degree=Pos	_	_	_	_
24	molecule	molecule	NOUN	NN	Number=Sing	_	_	_	_
25	during	during	ADP	IN	_	_	_	_	_
26	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
27	specific	specific	ADJ	JJ	Degree=Pos	_	_	_	_
28	phase	phase	NOUN	NN	Number=Sing	_	_	_	_
29	of	of	ADP	IN	_	_	_	_	_
30	B	b	ADJ	JJ	Degree=Pos	_	_	_	_
31	lymphoid	lymphoid	NOUN	NN	Number=Sing	_	_	_	_
32	development	development	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
33	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 2187
# text = Document 003003147 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	003003147	003003147	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 2188
# text = Expression of the nucleoside diphosphate kinase in human skin cancers: an immunohistochemical study.
1	Expression	expression	NOUN	NN	Number=Sing	_	_	_	_
2	of	of	ADP	IN	_	_	_	_	_
3	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
4	nucleoside	nucleoside	ADJ	JJ	Degree=Pos	_	_	_	_
5	diphosphate	diphosphate	NOUN	NN	Number=Sing	_	_	_	_
6	kinase	kinase	NOUN	NN	Number=Sing	_	_	_	_
7	in	in	ADP	IN	_	_	_	_	_
8	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
9	skin	skin	NOUN	NN	Number=Sing	_	_	_	_
10	cancers	cancer	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
11	:	:	PUNCT	:	_	_	_	_	_
12	an	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
13	immunohistochemical	immunohistochemical	ADJ	JJ	Degree=Pos	_	_	_	_
14	study	study	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
15	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 2189
# text = Expression of nucleoside diphosphate(NDP) kinase, which is homologous to the nm23 gene product in a variety of species, has been found to be inversely associated with metastatic potential.
1	Expression	expression	NOUN	NN	Number=Sing	_	_	_	_
2	of	of	ADP	IN	_	_	_	_	_
3	nucleoside	nucleoside	ADJ	JJ	Degree=Pos	_	_	_	_
4	diphosphate	diphosphate	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
5	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
6	NDP	NDP	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
7	)	)	PUNCT	-RRB-	_	_	_	_	_
8	kinase	kinase	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
9	,	,	PUNCT	,	_	_	_	_	_
10	which	which	PRON	WDT	PronType=Rel	_	_	_	_
11	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
12	homologous	homologous	ADJ	JJ	Degree=Pos	_	_	_	_
13	to	to	ADP	IN	_	_	_	_	_
14	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
15	nm23	nm23	NOUN	NN	Number=Sing	_	_	_	_
16	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
17	product	product	NOUN	NN	Number=Sing	_	_	_	_
18	in	in	ADP	IN	_	_	_	_	_
19	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
20	variety	variety	NOUN	NN	Number=Sing	_	_	_	_
21	of	of	ADP	IN	_	_	_	_	_
22	species	species	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
23	,	,	PUNCT	,	_	_	_	_	_
24	has	have	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
25	been	be	AUX	VBN	Tense=Past|VerbForm=Part	_	_	_	_
26	found	find	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
27	to	to	PART	TO	_	_	_	_	_
28	be	be	AUX	VB	VerbForm=Inf	_	_	_	_
29	inversely	inversely	ADV	RB	_	_	_	_	_
30	associated	associate	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
31	with	with	ADP	IN	_	_	_	_	_
32	metastatic	metastatic	ADJ	JJ	Degree=Pos	_	_	_	_
33	potential	potential	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
34	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2190
# text = However, the relationship remains controversial according to the tumor cell types and experimental system, with conflicting results from different research groups.
1	However	however	ADV	RB	_	_	_	_	SpaceAfter=No
2	,	,	PUNCT	,	_	_	_	_	_
3	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
4	relationship	relationship	NOUN	NN	Number=Sing	_	_	_	_
5	remains	remain	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
6	controversial	controversial	ADJ	JJ	Degree=Pos	_	_	_	_
7	according	accord	VERB	VBG	VerbForm=Ger	_	_	_	_
8	to	to	ADP	IN	_	_	_	_	_
9	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
10	tumor	tumor	NOUN	NN	Number=Sing	_	_	_	_
11	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
12	types	type	NOUN	NNS	Number=Plur	_	_	_	_
13	and	and	CCONJ	CC	_	_	_	_	_
14	experimental	experimental	ADJ	JJ	Degree=Pos	_	_	_	_
15	system	system	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
16	,	,	PUNCT	,	_	_	_	_	_
17	with	with	SCONJ	IN	_	_	_	_	_
18	conflicting	conflicte	VERB	VBG	VerbForm=Ger	_	_	_	_
19	results	result	NOUN	NNS	Number=Plur	_	_	_	_
20	from	from	ADP	IN	_	_	_	_	_
21	different	different	ADJ	JJ	Degree=Pos	_	_	_	_
22	research	research	NOUN	NN	Number=Sing	_	_	_	_
23	groups	group	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
24	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2191
# text = In order to determine whether NDP kinase expression serves as a marker for metastatic potential in human skin cancer, we assessed the levels of NDP kinase expression in 9 keratoacanthomas (KAs), 26 squamous cell carcinomas (SCCs), and 25 basal cell carcinomas (BCCs) using immunohistochemistry.
1	In	in	ADP	IN	_	_	_	_	_
2	order	order	NOUN	NN	Number=Sing	_	_	_	_
3	to	to	PART	TO	_	_	_	_	_
4	determine	determine	VERB	VB	VerbForm=Inf	_	_	_	_
5	whether	whether	SCONJ	IN	_	_	_	_	_
6	NDP	Ndp	PROPN	NNP	Number=Sing	_	_	_	_
7	kinase	kinase	NOUN	NN	Number=Sing	_	_	_	_
8	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
9	serves	serve	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
10	as	as	ADP	IN	_	_	_	_	_
11	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
12	marker	marker	NOUN	NN	Number=Sing	_	_	_	_
13	for	for	ADP	IN	_	_	_	_	_
14	metastatic	metastatic	ADJ	JJ	Degree=Pos	_	_	_	_
15	potential	potential	NOUN	NN	Number=Sing	_	_	_	_
16	in	in	ADP	IN	_	_	_	_	_
17	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
18	skin	skin	NOUN	NN	Number=Sing	_	_	_	_
19	cancer	cancer	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
20	,	,	PUNCT	,	_	_	_	_	_
21	we	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
22	assessed	assess	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
23	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
24	levels	level	NOUN	NNS	Number=Plur	_	_	_	_
25	of	of	ADP	IN	_	_	_	_	_
26	NDP	Ndp	NOUN	NN	Number=Sing	_	_	_	_
27	kinase	kinase	NOUN	NN	Number=Sing	_	_	_	_
28	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
29	in	in	ADP	IN	_	_	_	_	_
30	9	9	NUM	CD	NumType=Card	_	_	_	_
31	keratoacanthomas	keratoacanthoma	NOUN	NNS	Number=Plur	_	_	_	_
32	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
33	KAs	KAs	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
34	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
35	,	,	PUNCT	,	_	_	_	_	_
36	26	26	NUM	CD	NumType=Card	_	_	_	_
37	squamous	squamous	ADJ	JJ	Degree=Pos	_	_	_	_
38	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
39	carcinomas	carcinoma	NOUN	NNS	Number=Plur	_	_	_	_
40	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
41	SCCs	SCC	PROPN	NNPS	Number=Plur	_	_	_	SpaceAfter=No
42	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
43	,	,	PUNCT	,	_	_	_	_	_
44	and	and	CCONJ	CC	_	_	_	_	_
45	25	25	NUM	CD	NumType=Card	_	_	_	_
46	basal	basal	ADJ	JJ	Degree=Pos	_	_	_	_
47	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
48	carcinomas	carcinoma	NOUN	NNS	Number=Plur	_	_	_	_
49	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
50	BCCs	Bccs	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
51	)	)	PUNCT	-RRB-	_	_	_	_	_
52	using	use	VERB	VBG	VerbForm=Ger	_	_	_	_
53	immunohistochemistry	immunohistochemistry	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
54	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2192
# text = The expression of NDP kinase was intense in KA and SCC compared with BCC.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
3	of	of	ADP	IN	_	_	_	_	_
4	NDP	NDP	PROPN	NNP	Number=Sing	_	_	_	_
5	kinase	kinase	NOUN	NN	Number=Sing	_	_	_	_
6	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
7	intense	intense	ADJ	JJ	Degree=Pos	_	_	_	_
8	in	in	ADP	IN	_	_	_	_	_
9	KA	KA	PROPN	NNP	Number=Sing	_	_	_	_
10	and	and	CCONJ	CC	_	_	_	_	_
11	SCC	SCC	PROPN	NNP	Number=Sing	_	_	_	_
12	compared	compare	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
13	with	with	ADP	IN	_	_	_	_	_
14	BCC	BCC	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
15	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2193
# text = However, the difference of NDP kinase expression between KA and SCC was not statistically significant.
1	However	however	ADV	RB	_	_	_	_	SpaceAfter=No
2	,	,	PUNCT	,	_	_	_	_	_
3	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
4	difference	difference	NOUN	NN	Number=Sing	_	_	_	_
5	of	of	ADP	IN	_	_	_	_	_
6	NDP	NDP	PROPN	NNP	Number=Sing	_	_	_	_
7	kinase	kinase	NOUN	NN	Number=Sing	_	_	_	_
8	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
9	between	between	ADP	IN	_	_	_	_	_
10	KA	KA	PROPN	NNP	Number=Sing	_	_	_	_
11	and	and	CCONJ	CC	_	_	_	_	_
12	SCC	SCC	PROPN	NNP	Number=Sing	_	_	_	_
13	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
14	not	not	PART	RB	_	_	_	_	_
15	statistically	statistically	ADV	RB	_	_	_	_	_
16	significant	significant	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
17	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2194
# text = And there was no statistically significant difference in NDP kinase expression between SCC with metastasis and SCC without metastasis.
1	And	and	CCONJ	CC	_	_	_	_	_
2	there	there	PRON	EX	_	_	_	_	_
3	was	be	VERB	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
4	no	no	DET	DT	_	_	_	_	_
5	statistically	statistically	ADV	RB	_	_	_	_	_
6	significant	significant	ADJ	JJ	Degree=Pos	_	_	_	_
7	difference	difference	NOUN	NN	Number=Sing	_	_	_	_
8	in	in	ADP	IN	_	_	_	_	_
9	NDP	Ndp	PROPN	NNP	Number=Sing	_	_	_	_
10	kinase	kinase	NOUN	NN	Number=Sing	_	_	_	_
11	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
12	between	between	ADP	IN	_	_	_	_	_
13	SCC	Scc	NOUN	NN	Number=Sing	_	_	_	_
14	with	with	ADP	IN	_	_	_	_	_
15	metastasis	metastasis	NOUN	NN	Number=Sing	_	_	_	_
16	and	and	CCONJ	CC	_	_	_	_	_
17	SCC	Scc	NOUN	NN	Number=Sing	_	_	_	_
18	without	without	ADP	IN	_	_	_	_	_
19	metastasis	metastasis	PRON	DT	Number=Sing|PronType=Dem	_	_	_	SpaceAfter=No
20	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2195
# text = Our results contradict the hypothesis concerning the possible role of nm23 gene as a metastatic suppressor gene in human skin cancer.
1	Our	we	PRON	PRP$	Number=Plur|Person=1|Poss=Yes|PronType=Prs	_	_	_	_
2	results	result	NOUN	NNS	Number=Plur	_	_	_	_
3	contradict	contradict	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
4	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
5	hypothesis	hypothesis	NOUN	NN	Number=Sing	_	_	_	_
6	concerning	concern	VERB	VBG	VerbForm=Ger	_	_	_	_
7	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
8	possible	possible	ADJ	JJ	Degree=Pos	_	_	_	_
9	role	role	NOUN	NN	Number=Sing	_	_	_	_
10	of	of	ADP	IN	_	_	_	_	_
11	nm23	nm23	NUM	CD	NumType=Card	_	_	_	_
12	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
13	as	as	ADP	IN	_	_	_	_	_
14	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
15	metastatic	metastatic	ADJ	JJ	Degree=Pos	_	_	_	_
16	suppressor	suppressor	NOUN	NN	Number=Sing	_	_	_	_
17	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
18	in	in	ADP	IN	_	_	_	_	_
19	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
20	skin	skin	NOUN	NN	Number=Sing	_	_	_	_
21	cancer	cancer	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
22	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2196
# text = The mechanism of overexpression in various tumor cell types and its biological significance in cutaneous carcinogenesis remain to be determined.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	mechanism	mechanism	NOUN	NN	Number=Sing	_	_	_	_
3	of	of	ADP	IN	_	_	_	_	_
4	overexpression	overexpression	NOUN	NN	Number=Sing	_	_	_	_
5	in	in	ADP	IN	_	_	_	_	_
6	various	various	ADJ	JJ	Degree=Pos	_	_	_	_
7	tumor	tumor	NOUN	NN	Number=Sing	_	_	_	_
8	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
9	types	type	NOUN	NNS	Number=Plur	_	_	_	_
10	and	and	CCONJ	CC	_	_	_	_	_
11	its	its	PRON	PRP$	Gender=Neut|Number=Sing|Person=3|Poss=Yes|PronType=Prs	_	_	_	_
12	biological	biological	ADJ	JJ	Degree=Pos	_	_	_	_
13	significance	significance	NOUN	NN	Number=Sing	_	_	_	_
14	in	in	ADP	IN	_	_	_	_	_
15	cutaneous	cutaneous	ADJ	JJ	Degree=Pos	_	_	_	_
16	carcinogenesis	carcinogenesis	NOUN	NN	Number=Sing	_	_	_	_
17	remain	remain	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
18	to	to	PART	TO	_	_	_	_	_
19	be	be	AUX	VB	VerbForm=Inf	_	_	_	_
20	determined	determine	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	SpaceAfter=No
21	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 2197
# text = Document 003003150 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	003003150	003003150	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 2198
# text = Glucocorticoid receptors are down-regulated in inflamed colonic mucosa but not in peripheral blood mononuclear cells from patients with inflammatory bowel disease [see comments] BACKGROUND: Growing evidence indicates that the immune system and the hypothalamic-pituitary-adrenal system are linked by several mechanisms, for example intracellular glucocorticoid receptors (hGR).
1	Glucocorticoid	Glucocorticoid	ADJ	JJ	Degree=Pos	_	_	_	_
2	receptors	receptor	NOUN	NNS	Number=Plur	_	_	_	_
3	are	be	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
4	down	down	ADV	RB	_	_	_	_	SpaceAfter=No
5	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
6	regulated	regulate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
7	in	in	ADP	IN	_	_	_	_	_
8	inflamed	inflam	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
9	colonic	colonic	ADJ	JJ	Degree=Pos	_	_	_	_
10	mucosa	mucosa	NOUN	NN	Number=Sing	_	_	_	_
11	but	but	CCONJ	CC	_	_	_	_	_
12	not	not	PART	RB	_	_	_	_	_
13	in	in	ADP	IN	_	_	_	_	_
14	peripheral	peripheral	ADJ	JJ	Degree=Pos	_	_	_	_
15	blood	blood	NOUN	NN	Number=Sing	_	_	_	_
16	mononuclear	mononuclear	ADJ	JJ	Degree=Pos	_	_	_	_
17	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
18	from	from	ADP	IN	_	_	_	_	_
19	patients	patient	NOUN	NNS	Number=Plur	_	_	_	_
20	with	with	ADP	IN	_	_	_	_	_
21	inflammatory	inflammatory	ADJ	JJ	Degree=Pos	_	_	_	_
22	bowel	bowel	NOUN	NN	Number=Sing	_	_	_	_
23	disease	disease	NOUN	NN	Number=Sing	_	_	_	_
24	[	[	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
25	see	see	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
26	comments	comment	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
27	]	]	PUNCT	-RRB-	_	_	_	_	SpacesAfter=\s\n
28	BACKGROUND	background	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
29	:	:	PUNCT	:	_	_	_	_	_
30	Growing	growing	VERB	VBG	VerbForm=Ger	_	_	_	_
31	evidence	evidence	NOUN	NN	Number=Sing	_	_	_	_
32	indicates	indicate	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
33	that	that	SCONJ	IN	_	_	_	_	_
34	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
35	immune	immune	ADJ	JJ	Degree=Pos	_	_	_	_
36	system	system	NOUN	NN	Number=Sing	_	_	_	_
37	and	and	CCONJ	CC	_	_	_	_	_
38	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
39	hypothalamic	hypothalamic	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
40	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
41	pituitary	pituitary	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
42	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
43	adrenal	adrenal	ADJ	JJ	Degree=Pos	_	_	_	_
44	system	system	NOUN	NN	Number=Sing	_	_	_	_
45	are	be	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
46	linked	link	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
47	by	by	ADP	IN	_	_	_	_	_
48	several	several	ADJ	JJ	Degree=Pos	_	_	_	_
49	mechanisms	mechanism	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
50	,	,	PUNCT	,	_	_	_	_	_
51	for	for	ADP	IN	_	_	_	_	_
52	example	example	NOUN	NN	Number=Sing	_	_	_	_
53	intracellular	intracelular	ADJ	JJ	Degree=Pos	_	_	_	_
54	glucocorticoid	glucocorticoid	NOUN	NN	Number=Sing	_	_	_	_
55	receptors	receptor	NOUN	NNS	Number=Plur	_	_	_	_
56	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
57	hGR	hGR	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
58	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
59	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2199
# text = Glucocorticoids are the standard treatment of acute attacks of inflammatory bowel disease (IBD).
1	Glucocorticoids	Glucocorticoid	NOUN	NNS	Number=Plur	_	_	_	_
2	are	be	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
3	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
4	standard	standard	ADJ	JJ	Degree=Pos	_	_	_	_
5	treatment	treatment	NOUN	NN	Number=Sing	_	_	_	_
6	of	of	ADP	IN	_	_	_	_	_
7	acute	acute	ADJ	JJ	Degree=Pos	_	_	_	_
8	attacks	attack	NOUN	NNS	Number=Plur	_	_	_	_
9	of	of	ADP	IN	_	_	_	_	_
10	inflammatory	inflammatory	ADJ	JJ	Degree=Pos	_	_	_	_
11	bowel	bowel	NOUN	NN	Number=Sing	_	_	_	_
12	disease	disease	NOUN	NN	Number=Sing	_	_	_	_
13	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
14	IBD	IBD	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
15	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
16	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2200
# text = Binding of glucocorticoids to hGR down-regulates the transcription of inflammatory genes that can propagate IBD.
1	Binding	binding	NOUN	NN	Number=Sing	_	_	_	_
2	of	of	ADP	IN	_	_	_	_	_
3	glucocorticoids	glucocorticoid	NOUN	NNS	Number=Plur	_	_	_	_
4	to	to	PART	TO	_	_	_	_	_
5	hGR	hGR	VERB	VB	VerbForm=Inf	_	_	_	_
6	down	down	ADV	RB	_	_	_	_	SpaceAfter=No
7	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
8	regulates	regulate	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
9	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
10	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
11	of	of	ADP	IN	_	_	_	_	_
12	inflammatory	inflammatory	ADJ	JJ	Degree=Pos	_	_	_	_
13	genes	gene	NOUN	NNS	Number=Plur	_	_	_	_
14	that	that	PRON	WDT	PronType=Rel	_	_	_	_
15	can	can	AUX	MD	VerbForm=Fin	_	_	_	_
16	propagate	propagate	VERB	VB	VerbForm=Inf	_	_	_	_
17	IBD	IBD	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
18	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2201
# text = PATIENTS AND METHODS: IBD patients were either treated with 5-60 mg of prednisolone for more than 1 week or were without glucocorticoid treatment for more than 4 weeks.
1	PATIENTS	patient	NOUN	NNS	Number=Plur	_	_	_	_
2	AND	and	CCONJ	CC	_	_	_	_	_
3	METHODS	method	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	:	:	PUNCT	:	_	_	_	_	_
5	IBD	Ibd	ADJ	JJ	Degree=Pos	_	_	_	_
6	patients	patient	NOUN	NNS	Number=Plur	_	_	_	_
7	were	be	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
8	either	either	ADV	RB	_	_	_	_	_
9	treated	treat	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
10	with	with	ADP	IN	_	_	_	_	_
11	5	5	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
12	-	-	SYM	SYM	_	_	_	_	SpaceAfter=No
13	60	60	NUM	CD	NumType=Card	_	_	_	_
14	mg	mg	NOUN	NN	Number=Sing	_	_	_	_
15	of	of	ADP	IN	_	_	_	_	_
16	prednisolone	prednisolone	PRON	NN	Number=Sing	_	_	_	_
17	for	for	ADP	IN	_	_	_	_	_
18	more	more	ADJ	JJR	Degree=Cmp	_	_	_	_
19	than	than	ADP	IN	_	_	_	_	_
20	1	1	NUM	CD	NumType=Card	_	_	_	_
21	week	week	NOUN	NN	Number=Sing	_	_	_	_
22	or	or	CCONJ	CC	_	_	_	_	_
23	were	be	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
24	without	without	ADP	IN	_	_	_	_	_
25	glucocorticoid	glucocorticoid	ADJ	JJ	Degree=Pos	_	_	_	_
26	treatment	treatment	NOUN	NN	Number=Sing	_	_	_	_
27	for	for	ADP	IN	_	_	_	_	_
28	more	more	ADJ	JJR	Degree=Cmp	_	_	_	_
29	than	than	ADP	IN	_	_	_	_	_
30	4	4	NUM	CD	NumType=Card	_	_	_	_
31	weeks	week	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
32	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2202
# text = hGR levels were determined from isolated cytosol of peripheral blood mononuclear cells (PBMCs) or mucosal biopsies using a radioassay with [3H]-dexamethasone.
1	hGR	hgr	ADJ	JJR	Degree=Cmp	_	_	_	_
2	levels	level	NOUN	NNS	Number=Plur	_	_	_	_
3	were	be	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
4	determined	determine	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
5	from	from	ADP	IN	_	_	_	_	_
6	isolated	isolate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
7	cytosol	cytosol	NOUN	NN	Number=Sing	_	_	_	_
8	of	of	ADP	IN	_	_	_	_	_
9	peripheral	peripheral	ADJ	JJ	Degree=Pos	_	_	_	_
10	blood	blood	NOUN	NN	Number=Sing	_	_	_	_
11	mononuclear	mononuclear	ADJ	JJ	Degree=Pos	_	_	_	_
12	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
13	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
14	PBMCs	PBMC	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
15	)	)	PUNCT	-RRB-	_	_	_	_	_
16	or	or	CCONJ	CC	_	_	_	_	_
17	mucosal	mucosal	ADJ	JJ	Degree=Pos	_	_	_	_
18	biopsies	biopsy	NOUN	NNS	Number=Plur	_	_	_	_
19	using	use	VERB	VBG	VerbForm=Ger	_	_	_	_
20	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
21	radioassay	radioassay	NOUN	NN	Number=Sing	_	_	_	_
22	with	with	ADP	IN	_	_	_	_	_
23	[	[	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
24	3	3	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
25	H	h	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
26	]	]	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
27	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
28	dexamethasone	dexamethasone	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
29	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2203
# text = Interleukin (IL) 6 levels were determined by enzyme-linked immunosorbent assay (ELISA).
1	Interleukin	Interleukin	PROPN	NNP	Number=Sing	_	_	_	_
2	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
3	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
4	)	)	PUNCT	-RRB-	_	_	_	_	_
5	6	6	NUM	CD	NumType=Card	_	_	_	_
6	levels	level	NOUN	NNS	Number=Plur	_	_	_	_
7	were	be	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
8	determined	determine	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
9	by	by	ADP	IN	_	_	_	_	_
10	enzyme	enzyme	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
11	-linked	-link	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
12	immunosorbent	immunosorbent	ADJ	JJ	Degree=Pos	_	_	_	_
13	assay	assay	NOUN	NN	Number=Sing	_	_	_	_
14	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
15	ELISA	ELISA	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
16	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
17	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2204
# text = RESULTS: The systemic (PBMC) hGR levels of corticosteroid-treated IBD patients were significantly lower than those of control subjects (59.6 +/- 57.1 dpm mg-1 cytosol protein vs. 227.0 +/- 90.8 dpm mg-1 cytosol protein, P = 0.007) and IBD patients not receiving glucocorticoid treatment (179.7 +/- 171.3 dpm mg-1 cytosol protein, P = 0.002).
1	RESULTS	result	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
2	:	:	PUNCT	:	_	_	_	_	_
3	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
4	systemic	systemic	NOUN	NN	Number=Sing	_	_	_	_
5	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
6	PBMC	PBMC	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
7	)	)	PUNCT	-RRB-	_	_	_	_	_
8	hGR	hgr	NOUN	NN	Number=Sing	_	_	_	_
9	levels	level	NOUN	NNS	Number=Plur	_	_	_	_
10	of	of	ADP	IN	_	_	_	_	_
11	corticosteroid	corticosteroid	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
12	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
13	treated	treat	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
14	IBD	ibd	PROPN	NNP	Number=Sing	_	_	_	_
15	patients	patient	NOUN	NNS	Number=Plur	_	_	_	_
16	were	be	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
17	significantly	significantly	ADV	RB	_	_	_	_	_
18	lower	lower	ADJ	JJR	Degree=Cmp	_	_	_	_
19	than	than	ADP	IN	_	_	_	_	_
20	those	those	PRON	DT	Number=Plur|PronType=Dem	_	_	_	_
21	of	of	ADP	IN	_	_	_	_	_
22	control	control	NOUN	NN	Number=Sing	_	_	_	_
23	subjects	subject	NOUN	NNS	Number=Plur	_	_	_	_
24	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
25	59.6	59.6	NUM	CD	NumType=Card	_	_	_	_
26	+/-	+/-	SYM	SYM	_	_	_	_	_
27	57.1	57.1	NUM	CD	NumType=Card	_	_	_	_
28	dpm	dpm	NOUN	NN	Number=Sing	_	_	_	_
29	mg	mg	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
30	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
31	1	1	NUM	CD	NumType=Card	_	_	_	_
32	cytosol	cytosol	NOUN	NN	Number=Sing	_	_	_	_
33	protein	protein	NOUN	NN	Number=Sing	_	_	_	_
34	vs.	versus	ADP	IN	_	_	_	_	_
35	227.0	227.0	NUM	CD	NumType=Card	_	_	_	_
36	+/-	+/-	SYM	SYM	_	_	_	_	_
37	90.8	90.8	NUM	CD	NumType=Card	_	_	_	_
38	dpm	dpm	NOUN	NN	Number=Sing	_	_	_	_
39	mg	mg	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
40	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
41	1	1	NUM	CD	NumType=Card	_	_	_	_
42	cytosol	cytosol	NOUN	NN	Number=Sing	_	_	_	_
43	protein	protein	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
44	,	,	PUNCT	,	_	_	_	_	_
45	P	p	NOUN	NN	Number=Sing	_	_	_	_
46	=	=	SYM	SYM	_	_	_	_	_
47	0.007	0.007	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
48	)	)	PUNCT	-RRB-	_	_	_	_	_
49	and	and	CCONJ	CC	_	_	_	_	_
50	IBD	IBD	PROPN	NNP	Number=Sing	_	_	_	_
51	patient	patient	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
52	s	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
53	not	not	PART	RB	_	_	_	_	_
54	receiving	receive	VERB	VBG	Tense=Pres|VerbForm=Part	_	_	_	_
55	glucocorticoid	glucocorticoid	ADJ	JJ	Degree=Pos	_	_	_	_
56	treatment	treatment	NOUN	NN	Number=Sing	_	_	_	_
57	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
58	179.7	179.7	NUM	CD	NumType=Card	_	_	_	_
59	+/-	+/-	SYM	SYM	_	_	_	_	_
60	171.3	171.3	NUM	CD	NumType=Card	_	_	_	_
61	dpm	dpm	NOUN	NN	Number=Sing	_	_	_	_
62	mg	mg	VERB	VBG	VerbForm=Ger	_	_	_	SpaceAfter=No
63	-1	-1	NUM	CD	NumType=Card	_	_	_	_
64	cytosol	cytosol	NOUN	NN	Number=Sing	_	_	_	_
65	protein	protein	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
66	,	,	PUNCT	,	_	_	_	_	_
67	P	p	NOUN	NN	Number=Sing	_	_	_	_
68	=	=	SYM	SYM	_	_	_	_	_
69	0.002	0.002	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
70	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
71	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2205
# text = Systemic hGR levels in untreated IBD patients did not differ significantly from those in control subjects.
1	Systemic	Systemic	ADJ	JJ	Degree=Pos	_	_	_	_
2	hGR	hgr	NOUN	NN	Number=Sing	_	_	_	_
3	levels	level	NOUN	NNS	Number=Plur	_	_	_	_
4	in	in	ADP	IN	_	_	_	_	_
5	untreated	untreated	ADJ	JJ	Degree=Pos	_	_	_	_
6	IBD	Ibd	PROPN	NNP	Number=Sing	_	_	_	_
7	patients	patient	NOUN	NNS	Number=Plur	_	_	_	_
8	did	do	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
9	not	not	PART	RB	_	_	_	_	_
10	differ	differ	VERB	VB	VerbForm=Inf	_	_	_	_
11	significantly	significantly	ADV	RB	_	_	_	_	_
12	from	from	ADP	IN	_	_	_	_	_
13	those	those	PRON	DT	Number=Plur|PronType=Dem	_	_	_	_
14	in	in	ADP	IN	_	_	_	_	_
15	control	control	NOUN	NN	Number=Sing	_	_	_	_
16	subjects	subject	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
17	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2206
# text = In patients with connective tissue diseases, systemic hGR levels were also found to be decreased in the absence of glucocorticoid treatment.
1	In	in	ADP	IN	_	_	_	_	_
2	patients	patient	NOUN	NN	Number=Sing	_	_	_	_
3	with	with	ADP	IN	_	_	_	_	_
4	connective	connective	ADJ	JJ	Degree=Pos	_	_	_	_
5	tissue	tissue	NOUN	NN	Number=Sing	_	_	_	_
6	diseases	diseasis	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
7	,	,	PUNCT	,	_	_	_	_	_
8	systemic	systemic	ADJ	JJ	Degree=Pos	_	_	_	_
9	hGR	hgr	NOUN	NN	Number=Sing	_	_	_	_
10	levels	level	NOUN	NNS	Number=Plur	_	_	_	_
11	were	be	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
12	also	also	ADV	RB	_	_	_	_	_
13	found	find	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
14	to	to	PART	TO	_	_	_	_	_
15	be	be	AUX	VB	VerbForm=Inf	_	_	_	_
16	decreased	decrease	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
17	in	in	ADP	IN	_	_	_	_	_
18	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
19	absence	absence	NOUN	NN	Number=Sing	_	_	_	_
20	of	of	ADP	IN	_	_	_	_	_
21	glucocorticoid	glucocorticoid	ADJ	JJ	Degree=Pos	_	_	_	_
22	treatment	treatment	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
23	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2207
# text = Systemic hGR levels in patients with Crohn's disease (CD) treated with steroids (66.6 +/- 61.0 dpm mg-1 cytosol protein) were not different from those in patients with ulcerative colitis (UC) (56.1 +/- 51.6 dpm mg-1 cytosol protein).
1	Systemic	Systemic	ADJ	JJ	Degree=Pos	_	_	_	_
2	hGR	hgr	NOUN	NN	Number=Sing	_	_	_	_
3	levels	level	NOUN	NNS	Number=Plur	_	_	_	_
4	in	in	ADP	IN	_	_	_	_	_
5	patients	patient	NOUN	NNS	Number=Plur	_	_	_	_
6	with	with	ADP	IN	_	_	_	_	_
7	Crohn	Crohn	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
8	's	's	PART	POS	_	_	_	_	_
9	disease	disease	NOUN	NN	Number=Sing	_	_	_	_
10	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
11	CD	CD	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
12	)	)	PUNCT	-RRB-	_	_	_	_	_
13	treated	treat	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
14	with	with	ADP	IN	_	_	_	_	_
15	steroids	steroid	NOUN	NNS	Number=Plur	_	_	_	_
16	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
17	66.6	66.6	NUM	CD	NumType=Card	_	_	_	_
18	+/-	+/-	SYM	SYM	_	_	_	_	_
19	61.0	61.0	NUM	CD	NumType=Card	_	_	_	_
20	dpm	dpm	NOUN	NN	Number=Sing	_	_	_	_
21	mg	mg	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
22	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
23	1	1	NUM	CD	NumType=Card	_	_	_	_
24	cytosol	cytosol	NOUN	NN	Number=Sing	_	_	_	_
25	protein	protein	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
26	)	)	PUNCT	-RRB-	_	_	_	_	_
27	were	be	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
28	not	not	PART	RB	_	_	_	_	_
29	different	different	ADJ	JJ	Degree=Pos	_	_	_	_
30	from	from	ADP	IN	_	_	_	_	_
31	those	those	PRON	DT	Number=Plur|PronType=Dem	_	_	_	_
32	in	in	ADP	IN	_	_	_	_	_
33	patients	patient	NOUN	NNS	Number=Plur	_	_	_	_
34	with	with	ADP	IN	_	_	_	_	_
35	ulcerative	ulcerative	ADJ	JJ	Degree=Pos	_	_	_	_
36	colitis	colitis	NOUN	NN	Number=Sing	_	_	_	_
37	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
38	UC	Uc	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
39	)	)	PUNCT	-RRB-	_	_	_	_	_
40	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
41	56.1	56.1	NUM	CD	NumType=Card	_	_	_	_
42	+/-	+/-	SYM	SYM	_	_	_	_	_
43	51.6	51.6	NUM	CD	NumType=Card	_	_	_	_
44	dpm	dpm	NOUN	NN	Number=Sing	_	_	_	_
45	mg	mg	VERB	VBG	VerbForm=Ger	_	_	_	SpaceAfter=No
46	-1	-1	NUM	CD	NumType=Card	_	_	_	_
47	cytosol	cytosol	NOUN	NN	Number=Sing	_	_	_	_
48	protein	protein	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
49	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
50	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2208
# text = In contrast to these findings, mucosal hGR levels were significantly decreased in both steroid-treated (18.0 +/- 15.5) and not steroid-treated (37.8 +/- 30.5) patients compared with control subjects ( 125.6 +/- 97.1; P = 0.00009 and P = 0.0008 respectively ).
1	In	in	ADP	IN	_	_	_	_	_
2	contrast	contrast	NOUN	NN	Number=Sing	_	_	_	_
3	to	to	ADP	IN	_	_	_	_	_
4	these	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
5	findings	finding	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
6	,	,	PUNCT	,	_	_	_	_	_
7	mucosal	mucosal	ADJ	JJ	Degree=Pos	_	_	_	_
8	hGR	hgr	NOUN	NN	Number=Sing	_	_	_	_
9	levels	level	NOUN	NNS	Number=Plur	_	_	_	_
10	were	be	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
11	significantly	significantly	ADV	RB	_	_	_	_	_
12	decreased	decrease	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
13	in	in	ADP	IN	_	_	_	_	_
14	both	both	DET	DT	_	_	_	_	_
15	steroid	steroid	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
16	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
17	treated	treat	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
18	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
19	18.0	18.0	NUM	CD	NumType=Card	_	_	_	_
20	+/-	+/-	SYM	SYM	_	_	_	_	_
21	15.5	15.5	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
22	)	)	PUNCT	-RRB-	_	_	_	_	_
23	and	and	CCONJ	CC	_	_	_	_	_
24	not	not	ADV	RB	_	_	_	_	_
25	steroid	steroid	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	SpaceAfter=No
26	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
27	treated	treat	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
28	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
29	37.8	37.8	NUM	CD	NumType=Card	_	_	_	_
30	+/-	+/-	SYM	SYM	_	_	_	_	_
31	30.5	30.5	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
32	)	)	PUNCT	-RRB-	_	_	_	_	_
33	patients	patient	NOUN	NN	Number=Sing	_	_	_	_
34	compared	compare	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
35	with	with	ADP	IN	_	_	_	_	_
36	control	control	NOUN	NN	Number=Sing	_	_	_	_
37	subjects	subjects	NOUN	NNS	Number=Plur	_	_	_	_
38	(	(	PUNCT	-LRB-	_	_	_	_	_
39	125.6	125.6	NUM	CD	NumType=Card	_	_	_	_
40	+/-	+/-	SYM	SYM	_	_	_	_	_
41	97.1	97.1	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
42	;	;	PUNCT	,	_	_	_	_	_
43	P	p	NOUN	NN	Number=Sing	_	_	_	_
44	=	=	SYM	SYM	_	_	_	_	_
45	0.00009	0.00009	NUM	CD	NumType=Card	_	_	_	_
46	and	and	CCONJ	CC	_	_	_	_	_
47	P	p	NOUN	NN	Number=Sing	_	_	_	_
48	=	=	SYM	SYM	_	_	_	_	_
49	0.0008	0.0008	NUM	CD	NumType=Card	_	_	_	_
50	respectively	respectively	ADV	RB	_	_	_	_	_
51	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
52	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2209
# text = IL-6 levels in all IBD groups with and without steroids were significantly different from those in control subjects.
1	IL	Il	INTJ	UH	_	_	_	_	SpaceAfter=No
2	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
3	6	6	NUM	CD	NumType=Card	_	_	_	_
4	levels	level	NOUN	NNS	Number=Plur	_	_	_	_
5	in	in	ADP	IN	_	_	_	_	_
6	all	all	DET	DT	_	_	_	_	_
7	IBD	Ibd	ADJ	JJ	Degree=Pos	_	_	_	_
8	groups	group	NOUN	NNS	Number=Plur	_	_	_	_
9	with	with	ADP	IN	_	_	_	_	_
10	and	and	CCONJ	CC	_	_	_	_	_
11	without	without	ADP	IN	_	_	_	_	_
12	steroids	steroid	NOUN	NNS	Number=Plur	_	_	_	_
13	were	be	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
14	significantly	significantly	ADV	RB	_	_	_	_	_
15	different	different	ADJ	JJ	Degree=Pos	_	_	_	_
16	from	from	ADP	IN	_	_	_	_	_
17	those	those	PRON	DT	Number=Plur|PronType=Dem	_	_	_	_
18	in	in	ADP	IN	_	_	_	_	_
19	control	control	NOUN	NN	Number=Sing	_	_	_	_
20	subjects	subjects	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
21	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2210
# text = CONCLUSION: In IBD there is no difference in systemic hGR levels between not steroid-treated patients and control subjects, in spite of inflammatory activity (IL-6).
1	CONCLUSION	conclusion	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
2	:	:	PUNCT	:	_	_	_	_	_
3	In	in	ADP	IN	_	_	_	_	_
4	IBD	IBD	PROPN	NNP	Number=Sing	_	_	_	_
5	there	there	ADV	RB	PronType=Dem	_	_	_	_
6	is	be	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
7	no	no	DET	DT	_	_	_	_	_
8	difference	difference	NOUN	NN	Number=Sing	_	_	_	_
9	in	in	ADP	IN	_	_	_	_	_
10	systemic	systemic	ADJ	JJ	Degree=Pos	_	_	_	_
11	hGR	hgr	NOUN	NN	Number=Sing	_	_	_	_
12	levels	level	NOUN	NNS	Number=Plur	_	_	_	_
13	between	between	ADV	RB	_	_	_	_	_
14	not	not	PART	RB	_	_	_	_	_
15	steroid	steroid	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	SpaceAfter=No
16	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
17	treated	treat	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
18	patients	patient	NOUN	NNS	Number=Plur	_	_	_	_
19	and	and	CCONJ	CC	_	_	_	_	_
20	control	control	NOUN	NN	Number=Sing	_	_	_	_
21	subjects	subject	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
22	,	,	PUNCT	,	_	_	_	_	_
23	in	in	ADP	IN	_	_	_	_	_
24	spite	spite	NOUN	NN	Number=Sing	_	_	_	_
25	of	of	ADP	IN	_	_	_	_	_
26	inflammatory	inflammatory	ADJ	JJ	Degree=Pos	_	_	_	_
27	activity	activity	NOUN	NN	Number=Sing	_	_	_	_
28	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
29	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
30	-	-	SYM	SYM	_	_	_	_	SpaceAfter=No
31	6	6	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
32	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
33	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2211
# text = Mucosal hGR levels were decreased independently of treatment, probably leading to a decreased protection against NF-kappaB action in the intestinal mucosa.
1	Mucosal	Mucosal	ADJ	JJ	Degree=Pos	_	_	_	_
2	hGR	hgr	NOUN	NN	Number=Sing	_	_	_	_
3	levels	level	NOUN	NNS	Number=Plur	_	_	_	_
4	were	be	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
5	decreased	decrease	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
6	independently	independently	ADV	RB	_	_	_	_	_
7	of	of	ADP	IN	_	_	_	_	_
8	treatment	treatment	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
9	,	,	PUNCT	,	_	_	_	_	_
10	probably	probably	ADV	RB	_	_	_	_	_
11	leading	lead	VERB	VBG	VerbForm=Ger	_	_	_	_
12	to	to	ADP	IN	_	_	_	_	_
13	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
14	decreased	decrease	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
15	protection	protection	NOUN	NN	Number=Sing	_	_	_	_
16	against	against	ADP	IN	_	_	_	_	_
17	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
18	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
19	kappaB	kappaB	PROPN	NNP	Number=Sing	_	_	_	_
20	action	action	NOUN	NN	Number=Sing	_	_	_	_
21	in	in	ADP	IN	_	_	_	_	_
22	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
23	intestinal	intestinal	ADJ	JJ	Degree=Pos	_	_	_	_
24	mucosa	mucosa	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
25	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 2212
# text = Document 003003152 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	003003152	003003152	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 2213
# text = Expression of tal-1 and GATA-binding proteins during human hematopoiesis.
1	Expression	expression	NOUN	NN	Number=Sing	_	_	_	_
2	of	of	ADP	IN	_	_	_	_	_
3	tal	tal	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
4	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
5	1	1	NUM	CD	NumType=Card	_	_	_	_
6	and	and	CCONJ	CC	_	_	_	_	_
7	GATA	GATa	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
8	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
9	binding	binding	VERB	VBG	VerbForm=Ger	_	_	_	_
10	proteins	protein	NOUN	NNS	Number=Plur	_	_	_	_
11	during	during	ADP	IN	_	_	_	_	_
12	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
13	hematopoiesis	hematopoiesis	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
14	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 2214
# text = Tal-1 rearrangements are associated with nearly 30% of human T acute lymphoblastic leukemia.
1	Tal	Tal	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
2	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
3	1	1	NUM	CD	NumType=Card	_	_	_	_
4	rearrangements	rearrangement	NOUN	NNS	Number=Plur	_	_	_	_
5	are	be	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
6	associated	associate	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
7	with	with	ADP	IN	_	_	_	_	_
8	nearly	nearly	ADV	RB	_	_	_	_	_
9	30	30	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
10	%	%	SYM	NN	Number=Sing	_	_	_	_
11	of	of	ADP	IN	_	_	_	_	_
12	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
13	T	T	PROPN	NNP	Number=Sing	_	_	_	_
14	acute	acute	VERB	VB	VerbForm=Inf	_	_	_	_
15	lymphoblastic	lymphoblastic	ADJ	JJ	Degree=Pos	_	_	_	_
16	leukemia	leukemia	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
17	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2215
# text = Tal-1 gene encodes a putative transcription factor with a basic helix-loop-helix domain and is known to be predominantly expressed in hematopoietic cells.
1	Tal	Tal	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
2	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
3	1	1	NUM	CD	NumType=Card	_	_	_	_
4	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
5	encodes	encode	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
6	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
7	putative	putative	ADJ	JJ	Degree=Pos	_	_	_	_
8	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
9	factor	factor	NOUN	NN	Number=Sing	_	_	_	_
10	with	with	ADP	IN	_	_	_	_	_
11	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
12	basic	basic	ADJ	JJ	Degree=Pos	_	_	_	_
13	helix-loop	helix-loop	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
14	-helix	-helix	NOUN	NN	Number=Sing	_	_	_	_
15	domain	domain	NOUN	NN	Number=Sing	_	_	_	_
16	and	and	CCONJ	CC	_	_	_	_	_
17	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
18	known	know	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
19	to	to	PART	TO	_	_	_	_	_
20	be	be	AUX	VB	VerbForm=Inf	_	_	_	_
21	predominantly	predominantly	ADV	RB	_	_	_	_	_
22	expressed	express	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
23	in	in	ADP	IN	_	_	_	_	_
24	hematopoietic	hematopoietic	ADJ	JJ	Degree=Pos	_	_	_	_
25	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
26	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2216
# text = We investigated the pattern of tal-1 expression in purified human hematopoietic cells by in situ hybridization and reverse transcriptase polymerase chain reaction analysis.
1	We	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
2	investigated	investigate	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
3	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
4	pattern	pattern	NOUN	NN	Number=Sing	_	_	_	_
5	of	of	ADP	IN	_	_	_	_	_
6	tal	tal	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
7	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
8	1	1	NUM	CD	NumType=Card	_	_	_	_
9	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
10	in	in	ADP	IN	_	_	_	_	_
11	purified	purified	ADJ	JJ	Degree=Pos	_	_	_	_
12	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
13	hematopoietic	hematopoietic	ADJ	JJ	Degree=Pos	_	_	_	_
14	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
15	by	by	ADP	IN	_	_	_	_	_
16	in	in	ADP	IN	_	_	_	_	_
17	situ	situ	NOUN	NN	Number=Sing	_	_	_	_
18	hybridization	hybridization	NOUN	NN	Number=Sing	_	_	_	_
19	and	and	CCONJ	CC	_	_	_	_	_
20	reverse	reverse	NOUN	NN	Number=Sing	_	_	_	_
21	transcriptase	transcriptase	NOUN	NN	Number=Sing	_	_	_	_
22	polymerase	polymerase	NOUN	NN	Number=Sing	_	_	_	_
23	chain	chain	NOUN	NN	Number=Sing	_	_	_	_
24	reaction	reaction	NOUN	NN	Number=Sing	_	_	_	_
25	analysis	analysis	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
26	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2217
# text = Both methods demonstrated that the tal-1 gene is expressed in megakaryocytes and erythroblasts as well as in basophilic granulocytes.
1	Both	both	DET	DT	_	_	_	_	_
2	methods	method	NOUN	NNS	Number=Plur	_	_	_	_
3	demonstrated	demonstrate	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
4	that	that	SCONJ	IN	_	_	_	_	_
5	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
6	tal	tal	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
7	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
8	1	1	NUM	CD	NumType=Card	_	_	_	_
9	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
10	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
11	expressed	express	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
12	in	in	ADP	IN	_	_	_	_	_
13	megakaryocytes	megakaryocyte	NOUN	NNS	Number=Plur	_	_	_	_
14	and	and	CCONJ	CC	_	_	_	_	_
15	erythroblasts	erythroblast	NOUN	NNS	Number=Plur	_	_	_	_
16	as	as	ADV	RB	_	_	_	_	_
17	well	well	ADV	RB	Degree=Pos	_	_	_	_
18	as	as	ADP	IN	_	_	_	_	_
19	in	in	ADP	IN	_	_	_	_	_
20	basophilic	basophilic	ADJ	JJ	Degree=Pos	_	_	_	_
21	granulocytes	granulocyte	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
22	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2218
# text = In addition, our results indicate that the tal-1 1A promoter, which contains two consensus GATA-binding sites, is active mainly in these lineages.
1	In	in	ADP	IN	_	_	_	_	_
2	addition	addition	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
3	,	,	PUNCT	,	_	_	_	_	_
4	our	we	PRON	PRP$	Number=Plur|Person=1|Poss=Yes|PronType=Prs	_	_	_	_
5	results	result	NOUN	NNS	Number=Plur	_	_	_	_
6	indicate	indicate	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
7	that	that	SCONJ	IN	_	_	_	_	_
8	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
9	tal	tal	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
10	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
11	1	1	NUM	CD	NumType=Card	_	_	_	_
12	1	1	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
13	A	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
14	promoter	promoter	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
15	,	,	PUNCT	,	_	_	_	_	_
16	which	which	PRON	WDT	PronType=Rel	_	_	_	_
17	contains	contain	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
18	two	two	NUM	CD	NumType=Card	_	_	_	_
19	consensus	consensus	NOUN	NN	Number=Sing	_	_	_	_
20	GATA	GATa	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
21	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
22	binding	binding	VERB	VBG	VerbForm=Ger	_	_	_	_
23	sites	site	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
24	,	,	PUNCT	,	_	_	_	_	_
25	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
26	active	active	ADJ	JJ	Degree=Pos	_	_	_	_
27	mainly	mainly	ADV	RB	_	_	_	_	_
28	in	in	ADP	IN	_	_	_	_	_
29	these	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
30	lineages	lineage	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
31	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2219
# text = Because the GATA-1 gene is known to transactivate several genes specific for the erythroid, megakaryocytic, and mastocytic/basophilic lineages, we studied GATA-1 expression in these purified hematopoietic cells.
1	Because	because	SCONJ	IN	_	_	_	_	_
2	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
3	GATA	GATa	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
4	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
5	1	1	NUM	CD	NumType=Card	_	_	_	_
6	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
7	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
8	known	know	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
9	to	to	PART	TO	_	_	_	_	_
10	transactivate	transactivate	VERB	VB	VerbForm=Inf	_	_	_	_
11	several	several	ADJ	JJ	Degree=Pos	_	_	_	_
12	genes	gene	NOUN	NNS	Number=Plur	_	_	_	_
13	specific	specific	ADJ	JJ	Degree=Pos	_	_	_	_
14	for	for	ADP	IN	_	_	_	_	_
15	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
16	erythroid	erythroid	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
17	,	,	PUNCT	,	_	_	_	_	_
18	megakaryocytic	megakaryocytic	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
19	,	,	PUNCT	,	_	_	_	_	_
20	and	and	CCONJ	CC	_	_	_	_	_
21	mastocytic	mastocytic	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
22	/	/	PUNCT	,	_	_	_	_	SpaceAfter=No
23	basophilic	basophilic	ADJ	JJ	Degree=Pos	_	_	_	_
24	lineages	lineage	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
25	,	,	PUNCT	,	_	_	_	_	_
26	we	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
27	studied	study	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
28	GATA	GATA	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
29	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
30	1	1	NUM	CD	NumType=Card	_	_	_	_
31	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
32	in	in	ADP	IN	_	_	_	_	_
33	these	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
34	purified	purify	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
35	hematopoietic	hematopoietic	ADJ	JJ	Degree=Pos	_	_	_	_
36	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
37	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2220
# text = We found that GATA-1 and tal-1 genes are coexpressed in these three lineages.
1	We	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
2	found	find	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
3	that	that	SCONJ	IN	_	_	_	_	_
4	GATA	GATA	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
5	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
6	1	1	NUM	CD	NumType=Card	_	_	_	_
7	and	and	CCONJ	CC	_	_	_	_	_
8	tal	tal	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
9	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
10	1	1	NUM	CD	NumType=Card	_	_	_	_
11	genes	gene	NOUN	NNS	Number=Plur	_	_	_	_
12	are	be	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
13	coexpressed	coexpress	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
14	in	in	ADP	IN	_	_	_	_	_
15	these	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
16	three	three	NUM	CD	NumType=Card	_	_	_	_
17	lineages	lineage	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
18	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2221
# text = Remarkably, the expression of both genes is downmodulated during erythroid and megakaryocytic terminal maturation.
1	Remarkably	remarkably	ADV	RB	_	_	_	_	SpaceAfter=No
2	,	,	PUNCT	,	_	_	_	_	_
3	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
4	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
5	of	of	ADP	IN	_	_	_	_	_
6	both	both	DET	DT	_	_	_	_	_
7	genes	gene	NOUN	NNS	Number=Plur	_	_	_	_
8	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
9	downmodulated	downmodulate	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
10	during	during	ADP	IN	_	_	_	_	_
11	erythroid	erythroid	ADJ	JJ	Degree=Pos	_	_	_	_
12	and	and	CCONJ	CC	_	_	_	_	_
13	megakaryocytic	megakaryocytic	ADJ	JJ	Degree=Pos	_	_	_	_
14	terminal	terminal	ADJ	JJ	Degree=Pos	_	_	_	_
15	maturation	maturation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
16	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2222
# text = In immature hematopoietic cells, tal-1 and GATA-1 genes are coexpressed in committed progenitors cells (CD34+/CD38(2+)), whereas they are not detectable in the most primitive cells (CD34(2+)/CD38-).
1	In	in	ADP	IN	_	_	_	_	_
2	immature	immature	ADJ	JJ	Degree=Pos	_	_	_	_
3	hematopoietic	hematopoietic	ADJ	JJ	Degree=Pos	_	_	_	_
4	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
5	,	,	PUNCT	,	_	_	_	_	_
6	tal	tal	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
7	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
8	1	1	NUM	CD	NumType=Card	_	_	_	_
9	and	and	CCONJ	CC	_	_	_	_	_
10	GATA	GATa	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
11	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
12	1	1	NUM	CD	NumType=Card	_	_	_	_
13	genes	gene	NOUN	NNS	Number=Plur	_	_	_	_
14	are	be	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
15	coexpressed	coexpress	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
16	in	in	ADP	IN	_	_	_	_	_
17	committed	commit	ADJ	JJ	Degree=Pos	_	_	_	_
18	progenitors	progenitor	NOUN	NNS	Number=Plur	_	_	_	_
19	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
20	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
21	CD34+/CD38	Cd34+/cd38	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
22	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
23	2+	2+	SYM	SYM	_	_	_	_	SpaceAfter=No
24	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
25	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
26	,	,	PUNCT	,	_	_	_	_	_
27	whereas	whereas	SCONJ	IN	_	_	_	_	_
28	they	they	PRON	PRP	Case=Nom|Number=Plur|Person=3|PronType=Prs	_	_	_	_
29	are	be	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
30	not	not	PART	RB	_	_	_	_	_
31	detectable	detectable	ADJ	JJ	Degree=Pos	_	_	_	_
32	in	in	ADP	IN	_	_	_	_	_
33	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
34	most	most	ADV	RBS	_	_	_	_	_
35	primitive	primitive	ADJ	JJ	Degree=Pos	_	_	_	_
36	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
37	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
38	CD34	CD34	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
39	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
40	2+)	2+)	SYM	NFP	_	_	_	_	SpaceAfter=No
41	/CD38-)	/cd38-)	SYM	NFP	_	_	_	_	SpaceAfter=No
42	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2223
# text = In contrast, GATA-2 is strongly expressed in both most primitive and committed progenitors cells, whereas GATA-3 is mostly detected in most primitive ones.
1	In	in	ADP	IN	_	_	_	_	_
2	contrast	contrast	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
3	,	,	PUNCT	,	_	_	_	_	_
4	GATA	GATA	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
5	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
6	2	2	NUM	CD	NumType=Card	_	_	_	_
7	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
8	strongly	strongly	ADV	RB	_	_	_	_	_
9	expressed	express	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
10	in	in	ADP	IN	_	_	_	_	_
11	both	both	DET	DT	_	_	_	_	_
12	most	most	ADV	RBS	_	_	_	_	_
13	primitive	primitive	ADJ	JJ	Degree=Pos	_	_	_	_
14	and	and	CCONJ	CC	_	_	_	_	_
15	committed	commit	ADJ	JJ	Degree=Pos	_	_	_	_
16	progenitors	progenitor	NOUN	NNS	Number=Plur	_	_	_	_
17	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
18	,	,	PUNCT	,	_	_	_	_	_
19	whereas	whereas	SCONJ	IN	_	_	_	_	_
20	GATA	GATA	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
21	-	-	SYM	SYM	_	_	_	_	SpaceAfter=No
22	3	3	NUM	CD	NumType=Card	_	_	_	_
23	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
24	mostly	mostly	ADV	RB	_	_	_	_	_
25	detected	detect	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
26	in	in	ADP	IN	_	_	_	_	_
27	most	most	ADJ	JJS	Degree=Sup	_	_	_	_
28	primitive	primitive	ADJ	JJ	Degree=Pos	_	_	_	_
29	ones	one	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
30	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2224
# text = Altogether our results strongly suggest that GATA-1 modulates the transcription of tal-1 during the differentiation of the erythroid, megakaryocytic, and basosophilic lineages.
1	Altogether	altogether	ADV	RB	_	_	_	_	_
2	our	we	PRON	PRP$	Number=Plur|Person=1|Poss=Yes|PronType=Prs	_	_	_	_
3	results	result	NOUN	NNS	Number=Plur	_	_	_	_
4	strongly	strongly	ADV	RB	_	_	_	_	_
5	suggest	suggest	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
6	that	that	SCONJ	IN	_	_	_	_	_
7	GATA	GATa	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
8	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
9	1	1	NUM	CD	NumType=Card	_	_	_	_
10	modulates	modulate	NOUN	NNS	Number=Plur	_	_	_	_
11	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
12	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
13	of	of	ADP	IN	_	_	_	_	_
14	tal	tal	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
15	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
16	1	1	NUM	CD	NumType=Card	_	_	_	_
17	during	during	ADP	IN	_	_	_	_	_
18	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
19	differentiation	differentiation	NOUN	NN	Number=Sing	_	_	_	_
20	of	of	ADP	IN	_	_	_	_	_
21	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
22	erythroid	erythroid	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
23	,	,	PUNCT	,	_	_	_	_	_
24	megakaryocytic	megakaryocytic	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
25	,	,	PUNCT	,	_	_	_	_	_
26	and	and	CCONJ	CC	_	_	_	_	_
27	basosophilic	basosophilic	ADJ	JJ	Degree=Pos	_	_	_	_
28	lineages	lineage	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
29	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 2225
# text = Document 003003154 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	003003154	003003154	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 2226
# text = Activation of human CD4 T lymphocytes.
1	Activation	Activation	NOUN	NN	Number=Sing	_	_	_	_
2	of	of	ADP	IN	_	_	_	_	_
3	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
4	CD4	CD4	PROPN	NNP	Number=Sing	_	_	_	_
5	T	t	PROPN	NNP	Number=Sing	_	_	_	_
6	lymphocytes	lymphocyte	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
7	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2227
# text = Interaction of fibronectin with VLA-5 receptor on CD4 cells induces the AP-1 transcription factor.
1	Interaction	interaction	NOUN	NN	Number=Sing	_	_	_	_
2	of	of	ADP	IN	_	_	_	_	_
3	fibronectin	fibronectin	NOUN	NN	Number=Sing	_	_	_	_
4	with	with	ADP	IN	_	_	_	_	_
5	VLA	VLA	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
6	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
7	5	5	NUM	CD	NumType=Card	_	_	_	_
8	receptor	receptor	NOUN	NN	Number=Sing	_	_	_	_
9	on	on	ADP	IN	_	_	_	_	_
10	CD4	CD4	PROPN	NNP	Number=Sing	_	_	_	_
11	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
12	induces	induce	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
13	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
14	AP	ap	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
15	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
16	1	1	NUM	CD	NumType=Card	_	_	_	_
17	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
18	factor	factor	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
19	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 2228
# text = Fibronectin synergized with anti-CD3 antibody to promote CD4 cell proliferation in a serum-free culture system whereas no proliferation was observed when CD4 cells were cultured with anti-CD3 alone or fibronectin alone.
1	Fibronectin	Fibronectin	PROPN	NNP	Number=Sing	_	_	_	_
2	synergized	synergize	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
3	with	with	ADP	IN	_	_	_	_	_
4	anti-CD3	anti-CD3	NUM	CD	NumType=Card	_	_	_	_
5	antibody	antibody	ADJ	JJ	Degree=Pos	_	_	_	_
6	to	to	PART	TO	_	_	_	_	_
7	promote	promote	VERB	VB	VerbForm=Inf	_	_	_	_
8	CD4	CD4	NUM	CD	NumType=Card	_	_	_	_
9	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
10	proliferation	proliferation	NOUN	NN	Number=Sing	_	_	_	_
11	in	in	ADP	IN	_	_	_	_	_
12	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
13	serum	serum	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
14	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
15	free	free	ADJ	JJ	Degree=Pos	_	_	_	_
16	culture	culture	NOUN	NN	Number=Sing	_	_	_	_
17	system	system	NOUN	NN	Number=Sing	_	_	_	_
18	whereas	whereas	SCONJ	IN	_	_	_	_	_
19	no	no	DET	DT	_	_	_	_	_
20	proliferation	proliferation	NOUN	NN	Number=Sing	_	_	_	_
21	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
22	observed	observe	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
23	when	when	ADV	WRB	PronType=Int	_	_	_	_
24	CD4	CD4	NUM	CD	NumType=Card	_	_	_	_
25	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
26	were	be	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
27	cultured	culture	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
28	with	with	ADP	IN	_	_	_	_	_
29	anti-CD3	anti-CD3	NUM	CD	NumType=Card	_	_	_	_
30	alone	alone	ADJ	JJ	Degree=Pos	_	_	_	_
31	or	or	CCONJ	CC	_	_	_	_	_
32	fibronectin	fibronectin	ADV	RB	_	_	_	_	_
33	alone	alone	ADV	RB	_	_	_	_	SpaceAfter=No
34	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2229
# text = In addition, anti-CD29 (integrin beta 1) as well as anti-VLA-5 (human fibronectin receptor) antibodies blocked this CD4 cell activation in this system.
1	In	in	ADP	IN	_	_	_	_	_
2	addition	addition	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
3	,	,	PUNCT	,	_	_	_	_	_
4	anti-CD29	anti-CD29	NUM	CD	NumType=Card	_	_	_	_
5	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
6	integrin	integrin	NOUN	NN	Number=Sing	_	_	_	_
7	beta	beta	NOUN	NN	Number=Sing	_	_	_	_
8	1	1	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
9	)	)	PUNCT	-RRB-	_	_	_	_	_
10	as	as	ADV	RB	_	_	_	_	_
11	well	well	ADV	RB	Degree=Pos	_	_	_	_
12	as	as	ADP	IN	_	_	_	_	_
13	anti-VLA	anti-vla	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
14	-	-	SYM	SYM	_	_	_	_	SpaceAfter=No
15	5	5	NUM	CD	NumType=Card	_	_	_	_
16	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
17	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
18	fibronectin	fibronectin	NOUN	NN	Number=Sing	_	_	_	_
19	receptor	receptor	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
20	)	)	PUNCT	-RRB-	_	_	_	_	_
21	antibodies	antibody	NOUN	NNS	Number=Plur	_	_	_	_
22	blocked	block	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
23	this	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
24	CD4	Cd4	NOUN	NN	Number=Sing	_	_	_	_
25	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
26	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
27	in	in	ADP	IN	_	_	_	_	_
28	this	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
29	system	system	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
30	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2230
# text = Although anti-CD3 alone or fibronectin alone cannot induce IL-2 message by CD4 cells, the combination of anti-CD3 plus fibronectin induced IL-2 message by CD4 cells.
1	Although	although	SCONJ	IN	_	_	_	_	_
2	anti	anti	PRON	PRP	_	_	_	_	SpaceAfter=No
3	-CD3	-CD3	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
4	alone	alone	ADJ	JJ	Degree=Pos	_	_	_	_
5	or	or	CCONJ	CC	_	_	_	_	_
6	fibronectin	fibronectin	ADV	RB	_	_	_	_	_
7	alone	alone	ADV	RB	_	_	_	_	_
8	can	can	AUX	MD	VerbForm=Fin	_	_	_	SpaceAfter=No
9	not	not	PART	RB	_	_	_	_	_
10	induce	induce	VERB	VB	VerbForm=Inf	_	_	_	_
11	IL	Il	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
12	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
13	2	2	NUM	CD	NumType=Card	_	_	_	_
14	message	message	NOUN	NN	Number=Sing	_	_	_	_
15	by	by	ADP	IN	_	_	_	_	_
16	CD4	CD4	PROPN	NNP	Number=Sing	_	_	_	_
17	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
18	,	,	PUNCT	,	_	_	_	_	_
19	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
20	combination	combination	NOUN	NN	Number=Sing	_	_	_	_
21	of	of	ADP	IN	_	_	_	_	_
22	anti-CD3	anti-CD3	NUM	CD	NumType=Card	_	_	_	_
23	plus	plus	CCONJ	CC	_	_	_	_	_
24	fibronectin	fibronectin	NOUN	NN	Number=Sing	_	_	_	_
25	induced	induce	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
26	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
27	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
28	2	2	NUM	CD	NumType=Card	_	_	_	_
29	message	message	NOUN	NN	Number=Sing	_	_	_	_
30	by	by	ADP	IN	_	_	_	_	_
31	CD4	CD4	PROPN	NNP	Number=Sing	_	_	_	_
32	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
33	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2231
# text = In an analysis of the molecular mechanism by which IL-2 message was generated, we showed that a fibronectin-VLA-5 fibronectin receptor interaction may contribute an independent signal distinct from the CD3 pathway of activation by the induction of an AP-1 transcriptional factor.
1	In	in	ADP	IN	_	_	_	_	_
2	an	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
3	analysis	analysis	NOUN	NN	Number=Sing	_	_	_	_
4	of	of	ADP	IN	_	_	_	_	_
5	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
6	molecular	molecular	ADJ	JJ	Degree=Pos	_	_	_	_
7	mechanism	mechanism	NOUN	NN	Number=Sing	_	_	_	_
8	by	by	ADP	IN	_	_	_	_	_
9	which	which	PRON	WDT	PronType=Rel	_	_	_	_
10	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
11	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
12	2	2	NUM	CD	NumType=Card	_	_	_	_
13	message	message	NOUN	NN	Number=Sing	_	_	_	_
14	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
15	generated	generate	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	SpaceAfter=No
16	,	,	PUNCT	,	_	_	_	_	_
17	we	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
18	showed	show	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
19	that	that	SCONJ	IN	_	_	_	_	_
20	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
21	fibronectin	fibronectin	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
22	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
23	VLA	VLa	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
24	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
25	5	5	NUM	CD	NumType=Card	_	_	_	_
26	fibronectin	fibronectin	NOUN	NN	Number=Sing	_	_	_	_
27	receptor	receptor	NOUN	NN	Number=Sing	_	_	_	_
28	interaction	interaction	NOUN	NN	Number=Sing	_	_	_	_
29	may	may	AUX	MD	VerbForm=Fin	_	_	_	_
30	contribute	contribute	VERB	VB	VerbForm=Inf	_	_	_	_
31	an	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
32	independent	independent	ADJ	JJ	Degree=Pos	_	_	_	_
33	signal	signal	NOUN	NN	Number=Sing	_	_	_	_
34	distinct	distinct	ADJ	JJ	Degree=Pos	_	_	_	_
35	from	from	ADP	IN	_	_	_	_	_
36	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
37	CD3	CD3	NOUN	NN	Number=Sing	_	_	_	_
38	pathway	pathway	NOUN	NN	Number=Sing	_	_	_	_
39	of	of	ADP	IN	_	_	_	_	_
40	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
41	by	by	ADP	IN	_	_	_	_	_
42	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
43	induction	induction	NOUN	NN	Number=Sing	_	_	_	_
44	of	of	ADP	IN	_	_	_	_	_
45	an	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
46	AP	ap	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
47	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
48	1	1	NUM	CD	NumType=Card	_	_	_	_
49	transcriptional	transcriptional	ADJ	JJ	Degree=Pos	_	_	_	_
50	factor	factor	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
51	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2232
# text = Thus the VLA-5 fibronectin receptor on CD4 cells can play a complementary role in CD3-TCR-mediated signal transduction through its interaction with fibronectin.
1	Thus	thus	ADV	RB	_	_	_	_	_
2	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
3	VLA	VLa	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
4	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
5	5	5	NUM	CD	NumType=Card	_	_	_	_
6	fibronectin	fibronectin	NOUN	NN	Number=Sing	_	_	_	_
7	receptor	receptor	NOUN	NN	Number=Sing	_	_	_	_
8	on	on	ADP	IN	_	_	_	_	_
9	CD4	CD4	NUM	CD	NumType=Card	_	_	_	_
10	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
11	can	can	AUX	MD	VerbForm=Fin	_	_	_	_
12	play	play	VERB	VB	VerbForm=Inf	_	_	_	_
13	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
14	complementary	complementary	ADJ	JJ	Degree=Pos	_	_	_	_
15	role	role	NOUN	NN	Number=Sing	_	_	_	_
16	in	in	ADP	IN	_	_	_	_	_
17	CD3-TCR	CD3-TCR	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
18	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
19	mediated	mediate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
20	signal	signal	NOUN	NN	Number=Sing	_	_	_	_
21	transduction	transduction	NOUN	NN	Number=Sing	_	_	_	_
22	through	through	ADP	IN	_	_	_	_	_
23	its	its	PRON	PRP$	Gender=Neut|Number=Sing|Person=3|Poss=Yes|PronType=Prs	_	_	_	_
24	interaction	interaction	NOUN	NN	Number=Sing	_	_	_	_
25	with	with	ADP	IN	_	_	_	_	_
26	fibronectin	fibronectin	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
27	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 2233
# text = Document 003003157 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	003003157	003003157	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 2234
# text = Daidzein and genistein glucuronides in vitro are weakly estrogenic and activate human natural killer cells at nutritionally relevant concentrations.
1	Daidzein	Daidzein	PROPN	NNP	Number=Sing	_	_	_	_
2	and	and	CCONJ	CC	_	_	_	_	_
3	genistein	genistein	VERB	VB	VerbForm=Inf	_	_	_	_
4	glucuronides	glucuronide	NOUN	NNS	Number=Plur	_	_	_	_
5	in	in	ADP	IN	_	_	_	_	_
6	vitro	vitro	NOUN	NN	Number=Sing	_	_	_	_
7	are	be	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
8	weakly	weakly	ADV	RB	_	_	_	_	_
9	estrogenic	estrogenic	ADJ	JJ	Degree=Pos	_	_	_	_
10	and	and	CCONJ	CC	_	_	_	_	_
11	activate	activate	ADJ	JJ	Degree=Pos	_	_	_	_
12	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
13	natural	natural	ADJ	JJ	Degree=Pos	_	_	_	_
14	killer	killer	NOUN	NN	Number=Sing	_	_	_	_
15	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
16	at	at	ADP	IN	_	_	_	_	_
17	nutritionally	nutritionally	ADV	RB	_	_	_	_	_
18	relevant	relevant	ADJ	JJ	Degree=Pos	_	_	_	_
19	concentrations	concentration	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
20	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 2235
# text = Daidzein and genistein glucuronides (DG and GG), major isoflavone metabolites, may be partly responsible for biological effects of isoflavones, such as estrogen receptor binding and natural killer cell (NK) activation or inhibition.
1	Daidzein	Daidzein	PROPN	NNP	Number=Sing	_	_	_	_
2	and	and	CCONJ	CC	_	_	_	_	_
3	genistein	genistein	ADJ	JJ	Degree=Pos	_	_	_	_
4	glucuronides	glucuronide	NOUN	NNS	Number=Plur	_	_	_	_
5	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
6	DG	dg	PROPN	NNP	Number=Sing	_	_	_	_
7	and	and	CCONJ	CC	_	_	_	_	_
8	GG	GG	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
9	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
10	,	,	PUNCT	,	_	_	_	_	_
11	major	major	ADJ	JJ	Degree=Pos	_	_	_	_
12	isoflavone	isoflavone	NOUN	NN	Number=Sing	_	_	_	_
13	metabolites	metabolite	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
14	,	,	PUNCT	,	_	_	_	_	_
15	may	may	AUX	MD	VerbForm=Fin	_	_	_	_
16	be	be	AUX	VB	VerbForm=Inf	_	_	_	_
17	partly	partly	ADV	RB	_	_	_	_	_
18	responsible	responsible	ADJ	JJ	Degree=Pos	_	_	_	_
19	for	for	ADP	IN	_	_	_	_	_
20	biological	biological	ADJ	JJ	Degree=Pos	_	_	_	_
21	effects	effect	NOUN	NNS	Number=Plur	_	_	_	_
22	of	of	ADP	IN	_	_	_	_	_
23	isoflavones	isoflavone	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
24	,	,	PUNCT	,	_	_	_	_	_
25	such	such	ADJ	JJ	Degree=Pos	_	_	_	_
26	as	as	ADP	IN	_	_	_	_	_
27	estrogen	estrogen	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
28	receptor	receptor	NOUN	NN	Number=Sing	_	_	_	_
29	binding	binding	VERB	VBG	VerbForm=Ger	_	_	_	_
30	and	and	CCONJ	CC	_	_	_	_	_
31	natural	natural	ADJ	JJ	Degree=Pos	_	_	_	_
32	killer	killer	NOUN	NN	Number=Sing	_	_	_	_
33	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
34	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
35	NK	NK	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
36	)	)	PUNCT	-RRB-	_	_	_	_	_
37	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
38	or	or	CCONJ	CC	_	_	_	_	_
39	inhibition	inhibition	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
40	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2236
# text = DG and GG were synthesized using 3-methylcholanthrene-induced rat liver microsomes.
1	DG	dg	PROPN	NNP	Number=Sing	_	_	_	_
2	and	and	CCONJ	CC	_	_	_	_	_
3	GG	GG	PROPN	NNP	Number=Sing	_	_	_	_
4	were	be	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
5	synthesized	synthesize	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
6	using	use	VERB	VBG	VerbForm=Ger	_	_	_	_
7	3	3	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
8	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
9	methylcholanthrene-induced	methylcholanthrene-induce	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
10	rat	rat	NOUN	NN	Number=Sing	_	_	_	_
11	liver	liver	NOUN	NN	Number=Sing	_	_	_	_
12	microsomes	microsome	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
13	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2237
# text = The Km and Vmax for daidzein and genistein were 9.0 and 7.7 micromol/L, and 0.7 and 1.6 micromol/(mg protein.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	Km	Km	PROPN	NNP	Number=Sing	_	_	_	_
3	and	and	CCONJ	CC	_	_	_	_	_
4	Vmax	Vmax	PROPN	NNP	Number=Sing	_	_	_	_
5	for	for	ADP	IN	_	_	_	_	_
6	daidzein	daidzein	NOUN	NN	Number=Sing	_	_	_	_
7	and	and	CCONJ	CC	_	_	_	_	_
8	genistein	genistein	NOUN	NN	Number=Sing	_	_	_	_
9	were	be	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
10	9.0	9.0	NUM	CD	NumType=Card	_	_	_	_
11	and	and	CCONJ	CC	_	_	_	_	_
12	7.7	7.7	NUM	CD	NumType=Card	_	_	_	_
13	micromol/L	micromol/l	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
14	,	,	PUNCT	,	_	_	_	_	_
15	and	and	CCONJ	CC	_	_	_	_	_
16	0.7	0.7	NUM	CD	NumType=Card	_	_	_	_
17	and	and	CCONJ	CC	_	_	_	_	_
18	1.6	1.6	NUM	CD	NumType=Card	_	_	_	_
19	micromol	micromol	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
20	/	/	PUNCT	,	_	_	_	_	SpaceAfter=No
21	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
22	mg	mg	NOUN	NN	Number=Sing	_	_	_	_
23	protein	protein	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
24	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2238
# text = min), respectively.
1	min	min	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
2	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
3	,	,	PUNCT	,	_	_	_	_	_
4	respectively	respectively	ADV	RB	_	_	_	_	SpaceAfter=No
5	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2239
# text = The absence of ultraviolet absorbance maxima shifts in the presence of sodium acetate confirmed that the synthesized products were 7-O-glucuronides.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	absence	absence	NOUN	NN	Number=Sing	_	_	_	_
3	of	of	ADP	IN	_	_	_	_	_
4	ultraviolet	ultraviolet	X	ADD	_	_	_	_	_
5	absorbance	absorbance	X	FW	Foreign=Yes	_	_	_	_
6	maxima	maxima	X	FW	Foreign=Yes	_	_	_	_
7	shifts	shift	NOUN	NNS	Number=Plur	_	_	_	_
8	in	in	ADP	IN	_	_	_	_	_
9	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
10	presence	presence	NOUN	NN	Number=Sing	_	_	_	_
11	of	of	ADP	IN	_	_	_	_	_
12	sodium	sodium	NOUN	NN	Number=Sing	_	_	_	_
13	acetate	acetate	NOUN	NN	Number=Sing	_	_	_	_
14	confirmed	confirm	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
15	that	that	SCONJ	IN	_	_	_	_	_
16	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
17	synthesized	synthesized	ADJ	JJ	Degree=Pos	_	_	_	_
18	products	product	NOUN	NNS	Number=Plur	_	_	_	_
19	were	be	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
20	7	7	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
21	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
22	O	of	ADP	IN	Abbr=Yes	_	_	_	SpaceAfter=No
23	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
24	glucuronides	glucuronide	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
25	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2240
# text = DG and GG were further purified by a Sephadex LH-20 column.
1	DG	dg	PROPN	NNP	Number=Sing	_	_	_	_
2	and	and	CCONJ	CC	_	_	_	_	_
3	GG	GG	PROPN	NNP	Number=Sing	_	_	_	_
4	were	be	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
5	further	further	ADV	RB	_	_	_	_	_
6	purified	purify	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
7	by	by	ADP	IN	_	_	_	_	_
8	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
9	Sephadex	Sephadex	PROPN	NNP	Number=Sing	_	_	_	_
10	LH	Lh	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
11	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
12	20	20	NUM	CD	NumType=Card	_	_	_	_
13	column	column	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
14	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2241
# text = DG and GG competed with the binding of 17beta-(3H) estradiol to estrogen receptors of B6D2F1 mouse uterine cytosol.
1	DG	dg	PROPN	NNP	Number=Sing	_	_	_	_
2	and	and	CCONJ	CC	_	_	_	_	_
3	GG	GG	PROPN	NNP	Number=Sing	_	_	_	_
4	competed	compete	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
5	with	with	ADP	IN	_	_	_	_	_
6	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
7	binding	binding	NOUN	NN	Number=Sing	_	_	_	_
8	of	of	ADP	IN	_	_	_	_	_
9	17beta	17beta	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
10	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
11	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
12	3	3	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
13	H	h	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
14	)	)	PUNCT	-RRB-	_	_	_	_	_
15	estradiol	estradiol	NOUN	NN	Number=Sing	_	_	_	_
16	to	to	PART	TO	_	_	_	_	_
17	estrogen	estrogen	VERB	VB	VerbForm=Inf	_	_	_	_
18	receptors	receptor	NOUN	NNS	Number=Plur	_	_	_	_
19	of	of	ADP	IN	_	_	_	_	_
20	B6D2F1	B6D2F1	NOUN	NN	Number=Sing	_	_	_	_
21	mouse	mouse	NOUN	NN	Number=Sing	_	_	_	_
22	uterine	uterine	NOUN	NN	Number=Sing	_	_	_	_
23	cytosol	cytosol	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
24	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2242
# text = The concentrations required for 50% displacement of 17beta-(3H) estradiol (CB50) were: 17beta-estradiol, 1.34 nmol/L; diethylstilbestrol, 1.46 nmol/L; daidzein, 1.6 micromol/L; DG, 14.7 micromol/L; genistein, 0.154 micromol/L; GG, 7.27 micromol/L.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	concentrations	concentration	NOUN	NNS	Number=Plur	_	_	_	_
3	required	require	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
4	for	for	ADP	IN	_	_	_	_	_
5	50	50	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
6	%	%	SYM	NN	Number=Sing	_	_	_	_
7	displacement	displacement	NOUN	NN	Number=Sing	_	_	_	_
8	of	of	ADP	IN	_	_	_	_	_
9	17beta	17beta	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
10	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
11	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
12	3	3	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
13	H	h	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
14	)	)	PUNCT	-RRB-	_	_	_	_	_
15	estradiol	estradiol	NOUN	NN	Number=Sing	_	_	_	_
16	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
17	CB50	CB50	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
18	)	)	PUNCT	-RRB-	_	_	_	_	_
19	were	be	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	SpaceAfter=No
20	:	:	PUNCT	:	_	_	_	_	_
21	17beta	17beta	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
22	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
23	estradiol	estradiol	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
24	,	,	PUNCT	,	_	_	_	_	_
25	1.34	1.34	NUM	CD	NumType=Card	_	_	_	_
26	nmol/L	nmol/l	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
27	;	;	PUNCT	,	_	_	_	_	_
28	diethylstilbestrol	diethylstilbestrol	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
29	,	,	PUNCT	,	_	_	_	_	_
30	1.46	1.46	NUM	CD	NumType=Card	_	_	_	_
31	nmol/L	nmol/l	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
32	;	;	PUNCT	,	_	_	_	_	_
33	daidzein	daidzein	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
34	,	,	PUNCT	,	_	_	_	_	_
35	1.6	1.6	NUM	CD	NumType=Card	_	_	_	_
36	micromol/L	micromol/l	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
37	;	;	PUNCT	,	_	_	_	_	_
38	DG	DG	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
39	,	,	PUNCT	,	_	_	_	_	_
40	14.7	14.7	NUM	CD	NumType=Card	_	_	_	_
41	micromol/L	micromol/l	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
42	;	;	PUNCT	,	_	_	_	_	_
43	genistein	genistein	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
44	,	,	PUNCT	,	_	_	_	_	_
45	0.154	0.154	NUM	CD	NumType=Card	_	_	_	_
46	micromol/L	micromol/l	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
47	;	;	PUNCT	,	_	_	_	_	_
48	GG	GG	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
49	,	,	PUNCT	,	_	_	_	_	_
50	7.27	7.27	NUM	CD	NumType=Card	_	_	_	_
51	micromol/L.	micromol/L.	NOUN	NN	Number=Sing	_	_	_	_

# sent_id = 2243
# text = In human peripheral blood NK cells, genistein at <0.5 micromol/L and DG and GG at 0.1-10 micromol/L enhanced NK cell-mediated K562 cancer cell killing significantly (P < 0.05).
1	In	in	ADP	IN	_	_	_	_	_
2	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
3	peripheral	peripheral	ADJ	JJ	Degree=Pos	_	_	_	_
4	blood	blood	NOUN	NN	Number=Sing	_	_	_	_
5	NK	NK	PROPN	NNP	Number=Sing	_	_	_	_
6	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
7	,	,	PUNCT	,	_	_	_	_	_
8	genistein	genistein	ADJ	JJ	Degree=Pos	_	_	_	_
9	at	at	ADP	IN	_	_	_	_	_
10	<	<	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
11	0.5	0.5	NUM	CD	NumType=Card	_	_	_	_
12	micromol/L	micromol/L	NOUN	NN	Number=Sing	_	_	_	_
13	and	and	CCONJ	CC	_	_	_	_	_
14	DG	dg	PROPN	NNP	Number=Sing	_	_	_	_
15	and	and	CCONJ	CC	_	_	_	_	_
16	GG	GG	PROPN	NNP	Number=Sing	_	_	_	_
17	at	at	ADP	IN	_	_	_	_	_
18	0.1	0.1	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
19	-	-	SYM	SYM	_	_	_	_	SpaceAfter=No
20	10	10	NUM	CD	NumType=Card	_	_	_	_
21	micromol/L	micromol/l	NOUN	NN	Number=Sing	_	_	_	_
22	enhanced	enhance	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
23	NK	NK	PROPN	NNP	Number=Sing	_	_	_	_
24	cell	cell	ADV	RB	Degree=Pos	_	_	_	SpaceAfter=No
25	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
26	mediated	mediate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
27	K562	k562	NUM	CD	NumType=Card	_	_	_	_
28	cancer	cancer	NOUN	NN	Number=Sing	_	_	_	_
29	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
30	killing	killing	VERB	VBG	VerbForm=Ger	_	_	_	_
31	significantly	significantly	ADV	RB	_	_	_	_	_
32	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
33	P	p	NOUN	NN	Number=Sing	_	_	_	_
34	<	<	PUNCT	-LRB-	_	_	_	_	_
35	0.05	0.05	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
36	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
37	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2244
# text = At > 0.5 micromol/L, genistein inhibited NK cytotoxicity significantly (P < 0.05).
1	At	at	ADP	IN	_	_	_	_	_
2	>	>	PUNCT	-RRB-	_	_	_	_	_
3	0.5	0.5	NUM	CD	NumType=Card	_	_	_	_
4	micromol/L	micromol/l	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
5	,	,	PUNCT	,	_	_	_	_	_
6	genistein	genistein	ADV	WRB	PronType=Rel	_	_	_	_
7	inhibited	inhibit	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
8	NK	NK	PROPN	NNP	Number=Sing	_	_	_	_
9	cytotoxicity	cytotoxicity	NOUN	NN	Number=Sing	_	_	_	_
10	significantly	significantly	ADV	RB	_	_	_	_	_
11	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
12	P	p	NOUN	NN	Number=Sing	_	_	_	_
13	<	<	PUNCT	-LRB-	_	_	_	_	_
14	0.05	0.05	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
15	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
16	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2245
# text = The glucuronides only inhibited NK cytotoxicity at 50 micromol/L.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	glucuronides	glucuronide	NOUN	NNS	Number=Plur	_	_	_	_
3	only	only	ADV	RB	_	_	_	_	_
4	inhibited	inhibit	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
5	NK	NK	PROPN	NNP	Number=Sing	_	_	_	_
6	cytotoxicity	cytotoxicity	NOUN	NN	Number=Sing	_	_	_	_
7	at	at	ADP	IN	_	_	_	_	_
8	50	50	NUM	CD	NumType=Card	_	_	_	_
9	micromol/L.	micromol/L.	PROPN	NNP	Number=Sing	_	_	_	_

# sent_id = 2246
# text = Isoflavones, and especially the isoflavone glucuronides, enhanced activation of NK cells by interleukin-2 (IL-2), additively.
1	Isoflavones	Isoflavone	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
2	,	,	PUNCT	,	_	_	_	_	_
3	and	and	CCONJ	CC	_	_	_	_	_
4	especially	especially	ADV	RB	_	_	_	_	_
5	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
6	isoflavone	isoflavone	ADJ	JJ	Degree=Pos	_	_	_	_
7	glucuronides	glucuronide	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
8	,	,	PUNCT	,	_	_	_	_	_
9	enhanced	enhance	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
10	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
11	of	of	ADP	IN	_	_	_	_	_
12	NK	NK	PROPN	NNP	Number=Sing	_	_	_	_
13	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
14	by	by	ADP	IN	_	_	_	_	_
15	interleukin	interleukin	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
16	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
17	2	2	NUM	CD	NumType=Card	_	_	_	_
18	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
19	IL	Il	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
20	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
21	2	2	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
22	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
23	,	,	PUNCT	,	_	_	_	_	_
24	additively	additively	ADV	RB	_	_	_	_	SpaceAfter=No
25	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2247
# text = At physiological concentrations, DG and GG were weakly estrogenic, and they activated human NK cells in nutritionally relevant concentrations in vitro, probably at a site different from IL-2 action.
1	At	at	ADP	IN	_	_	_	_	_
2	physiological	physiological	ADJ	JJ	Degree=Pos	_	_	_	_
3	concentrations	concentration	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	,	,	PUNCT	,	_	_	_	_	_
5	DG	dg	PROPN	NNP	Number=Sing	_	_	_	_
6	and	and	CCONJ	CC	_	_	_	_	_
7	GG	GG	PROPN	NNP	Number=Sing	_	_	_	_
8	were	be	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
9	weakly	weakly	ADV	RB	_	_	_	_	_
10	estrogenic	estrogenic	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
11	,	,	PUNCT	,	_	_	_	_	_
12	and	and	CCONJ	CC	_	_	_	_	_
13	they	they	PRON	PRP	Case=Nom|Number=Plur|Person=3|PronType=Prs	_	_	_	_
14	activated	activate	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
15	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
16	NK	Nk	PROPN	NNP	Number=Sing	_	_	_	_
17	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
18	in	in	ADP	IN	_	_	_	_	_
19	nutritionally	nutritionally	ADV	RB	_	_	_	_	_
20	relevant	relevant	ADJ	JJ	Degree=Pos	_	_	_	_
21	concentrations	concentration	NOUN	NNS	Number=Plur	_	_	_	_
22	in	in	ADP	IN	_	_	_	_	_
23	vitro	vitro	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
24	,	,	PUNCT	,	_	_	_	_	_
25	probably	probably	ADV	RB	_	_	_	_	_
26	at	at	ADP	IN	_	_	_	_	_
27	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
28	site	site	NOUN	NN	Number=Sing	_	_	_	_
29	different	different	NOUN	NN	Number=Sing	_	_	_	_
30	from	from	ADP	IN	_	_	_	_	_
31	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
32	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
33	2	2	NUM	CD	NumType=Card	_	_	_	_
34	action	action	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
35	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 2248
# text = Document 003003160 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	003003160	003003160	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 2249
# text = The human TCF-1 gene encodes a nuclear DNA-binding protein uniquely expressed in normal and neoplastic T-lineage lymphocytes.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
3	TCF	Tcf	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
4	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
5	1	1	NUM	CD	NumType=Card	_	_	_	_
6	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
7	encodes	encode	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
8	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
9	nuclear	nuclear	ADJ	JJ	Degree=Pos	_	_	_	_
10	DNA	dna	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
11	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
12	binding	bind	VERB	VBG	VerbForm=Ger	_	_	_	_
13	protein	protein	NOUN	NN	Number=Sing	_	_	_	_
14	uniquely	uniquely	ADV	RB	_	_	_	_	_
15	expressed	express	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
16	in	in	ADP	IN	_	_	_	_	_
17	normal	normal	ADJ	JJ	Degree=Pos	_	_	_	_
18	and	and	CCONJ	CC	_	_	_	_	_
19	neoplastic	neoplastic	ADJ	JJ	Degree=Pos	_	_	_	_
20	T-	t-	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
21	lineage	lineage	NOUN	NN	Number=Sing	_	_	_	_
22	lymphocytes	lymphocyte	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
23	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 2250
# text = The TCF-1 gene encodes a putative transcription factor with affinity for a sequence motif occurring in a number of T-cell enhancers.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	TCF	Tcf	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
3	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
4	1	1	NUM	CD	NumType=Card	_	_	_	_
5	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
6	encodes	encode	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
7	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
8	putative	putative	ADJ	JJ	Degree=Pos	_	_	_	_
9	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
10	factor	factor	NOUN	NN	Number=Sing	_	_	_	_
11	with	with	ADP	IN	_	_	_	_	_
12	affinity	affinity	NOUN	NN	Number=Sing	_	_	_	_
13	for	for	ADP	IN	_	_	_	_	_
14	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
15	sequence	sequence	NOUN	NN	Number=Sing	_	_	_	_
16	motif	motif	SCONJ	IN	_	_	_	_	_
17	occurring	occurre	VERB	VBG	VerbForm=Ger	_	_	_	_
18	in	in	ADP	IN	_	_	_	_	_
19	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
20	number	number	NOUN	NN	Number=Sing	_	_	_	_
21	of	of	ADP	IN	_	_	_	_	_
22	T-	t-	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
23	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
24	enhancers	enhancer	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
25	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2251
# text = TCF-1 mRNA was originally found to be expressed in a T cell-specific fashion within a set of human and mouse cell lines.
1	TCF	Tcf	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
2	-	-	PUNCT	:	_	_	_	_	SpaceAfter=No
3	1	1	NUM	CD	NumType=Card	_	_	_	_
4	mRNA	mRNa	NOUN	NN	Number=Sing	_	_	_	_
5	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
6	originally	originally	ADV	RB	_	_	_	_	_
7	found	find	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
8	to	to	PART	TO	_	_	_	_	_
9	be	be	AUX	VB	VerbForm=Inf	_	_	_	_
10	expressed	express	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
11	in	in	ADP	IN	_	_	_	_	_
12	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
13	T	t	PROPN	NNP	Number=Sing	_	_	_	_
14	cell	cell	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
15	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
16	specific	specific	ADJ	JJ	Degree=Pos	_	_	_	_
17	fashion	fashion	NOUN	NN	Number=Sing	_	_	_	_
18	within	within	ADP	IN	_	_	_	_	_
19	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
20	set	set	NOUN	NN	Number=Sing	_	_	_	_
21	of	of	ADP	IN	_	_	_	_	_
22	human	human	NOUN	NN	Number=Sing	_	_	_	_
23	and	and	CCONJ	CC	_	_	_	_	_
24	mouse	mouse	NOUN	NN	Number=Sing	_	_	_	_
25	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
26	lines	line	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
27	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2252
# text = In contrast, expression reportedly occurs in multiple nonlymphoid tissues during murine embryogenesis.
1	In	in	ADP	IN	_	_	_	_	_
2	contrast	contrast	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
3	,	,	PUNCT	,	_	_	_	_	_
4	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
5	reportedly	reportedly	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
6	occurs	occur	NOUN	NNS	Number=Plur	_	_	_	_
7	in	in	ADP	IN	_	_	_	_	_
8	multiple	multiple	ADJ	JJ	Degree=Pos	_	_	_	_
9	nonlymphoid	nonlymphoid	ADJ	JJ	Degree=Pos	_	_	_	_
10	tissues	tissue	NOUN	NNS	Number=Plur	_	_	_	_
11	during	during	ADP	IN	_	_	_	_	_
12	murine	murine	NOUN	NN	Number=Sing	_	_	_	_
13	embryogenesis	embryogenesis	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
14	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2253
# text = We have now raised a monoclonal antibody to document expression and biochemistry of the human TCF-1 protein.
1	We	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
2	have	have	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
3	now	now	ADV	RB	_	_	_	_	_
4	raised	raise	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
5	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
6	monoclonal	monoclonal	ADJ	JJ	Degree=Pos	_	_	_	_
7	antibody	antibody	NOUN	NN	Number=Sing	_	_	_	_
8	to	to	PART	TO	_	_	_	_	_
9	document	document	VERB	VB	VerbForm=Inf	_	_	_	_
10	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
11	and	and	CCONJ	CC	_	_	_	_	_
12	biochemistry	biochemistry	NOUN	NN	Number=Sing	_	_	_	_
13	of	of	ADP	IN	_	_	_	_	_
14	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
15	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
16	TCF	TCF	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
17	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
18	1	1	NUM	CD	NumType=Card	_	_	_	_
19	protein	protein	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
20	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2254
# text = As expected, the TCF-1 protein was detectable only in cell lines of T lineage.
1	As	as	ADP	IN	_	_	_	_	_
2	expected	expect	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	SpaceAfter=No
3	,	,	PUNCT	,	_	_	_	_	_
4	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
5	TCF	Tcf	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
6	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
7	1	1	NUM	CD	NumType=Card	_	_	_	_
8	protein	protein	NOUN	NN	Number=Sing	_	_	_	_
9	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
10	detectable	detectable	ADJ	JJ	Degree=Pos	_	_	_	_
11	only	only	ADV	RB	_	_	_	_	_
12	in	in	ADP	IN	_	_	_	_	_
13	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
14	lines	line	NOUN	NNS	Number=Plur	_	_	_	_
15	of	of	ADP	IN	_	_	_	_	_
16	T	t	PROPN	NNP	Number=Sing	_	_	_	_
17	lineage	lineage	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
18	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2255
# text = Its expression was always restricted to the nucleus.
1	Its	its	PRON	PRP$	Gender=Neut|Number=Sing|Person=3|Poss=Yes|PronType=Prs	_	_	_	_
2	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
3	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
4	always	always	ADV	RB	_	_	_	_	_
5	restricted	restrict	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
6	to	to	ADP	IN	_	_	_	_	_
7	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
8	nucleus	nucleus	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
9	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2256
# text = Immunohistochemistry on a panel of human tissues revealed that the TCF-1 protein was found exclusively in thymocytes and in CD3+ T cells in peripheral lymphoid tissues.
1	Immunohistochemistry	Immunohistochemistry	VERB	VB	Mood=Imp|VerbForm=Fin	_	_	_	_
2	on	on	ADP	IN	_	_	_	_	_
3	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
4	panel	panel	NOUN	NN	Number=Sing	_	_	_	_
5	of	of	ADP	IN	_	_	_	_	_
6	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
7	tissues	tissue	NOUN	NNS	Number=Plur	_	_	_	_
8	revealed	reveal	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
9	that	that	SCONJ	IN	_	_	_	_	_
10	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
11	TCF	Tcf	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
12	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
13	1	1	NUM	CD	NumType=Card	_	_	_	_
14	protein	protein	NOUN	NN	Number=Sing	_	_	_	_
15	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
16	found	find	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
17	exclusively	exclusively	ADV	RB	_	_	_	_	_
18	in	in	ADP	IN	_	_	_	_	_
19	thymocytes	thymocyte	NOUN	NNS	Number=Plur	_	_	_	_
20	and	and	CCONJ	CC	_	_	_	_	_
21	in	in	ADP	IN	_	_	_	_	_
22	CD3	CD3	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
23	+	+	SYM	SYM	_	_	_	_	_
24	T	t	NUM	CD	NumType=Card	_	_	_	_
25	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
26	in	in	ADP	IN	_	_	_	_	_
27	peripheral	peripheral	ADJ	JJ	Degree=Pos	_	_	_	_
28	lymphoid	lymphoid	ADJ	JJ	Degree=Pos	_	_	_	_
29	tissues	tissue	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
30	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2257
# text = Western blotting yielded a set of bands ranging from 25 kD to 55 kD, resulting from extensive alternative splicing.
1	Western	western	ADJ	JJ	Degree=Pos	_	_	_	_
2	blotting	blotting	NOUN	NN	Number=Sing	_	_	_	_
3	yielded	yield	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
4	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
5	set	set	NOUN	NN	Number=Sing	_	_	_	_
6	of	of	ADP	IN	_	_	_	_	_
7	bands	band	NOUN	NNS	Number=Plur	_	_	_	_
8	ranging	rang	VERB	VBG	VerbForm=Ger	_	_	_	_
9	from	from	ADP	IN	_	_	_	_	_
10	25	25	NUM	CD	NumType=Card	_	_	_	_
11	kD	kD	NOUN	NN	Number=Sing	_	_	_	_
12	to	to	ADP	IN	_	_	_	_	_
13	55	55	NUM	CD	NumType=Card	_	_	_	_
14	kD	kD	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
15	,	,	PUNCT	,	_	_	_	_	_
16	resulting	result	VERB	VBG	VerbForm=Ger	_	_	_	_
17	from	from	ADP	IN	_	_	_	_	_
18	extensive	extensive	ADJ	JJ	Degree=Pos	_	_	_	_
19	alternative	alternative	ADJ	JJ	Degree=Pos	_	_	_	_
20	splicing	splicing	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
21	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2258
# text = The TCF-1 protein was detectable in all samples of a set of 22 T-cell malignancies of various stages of maturation, but was absent from a large number of other hematologic neoplasms.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	TCF	Tcf	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
3	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
4	1	1	NUM	CD	NumType=Card	_	_	_	_
5	protein	protein	NOUN	NN	Number=Sing	_	_	_	_
6	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
7	detectable	detectable	ADJ	JJ	Degree=Pos	_	_	_	_
8	in	in	ADP	IN	_	_	_	_	_
9	all	all	DET	DT	_	_	_	_	_
10	samples	sample	NOUN	NNS	Number=Plur	_	_	_	_
11	of	of	ADP	IN	_	_	_	_	_
12	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
13	set	set	NOUN	NN	Number=Sing	_	_	_	_
14	of	of	ADP	IN	_	_	_	_	_
15	22	22	NUM	CD	NumType=Card	_	_	_	_
16	T-	T-	PUNCT	:	_	_	_	_	SpaceAfter=No
17	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
18	malignancies	malignancy	NOUN	NNS	Number=Plur	_	_	_	_
19	of	of	ADP	IN	_	_	_	_	_
20	various	various	ADJ	JJ	Degree=Pos	_	_	_	_
21	stages	stage	NOUN	NNS	Number=Plur	_	_	_	_
22	of	of	ADP	IN	_	_	_	_	_
23	maturation	maturation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
24	,	,	PUNCT	,	_	_	_	_	_
25	but	but	CCONJ	CC	_	_	_	_	_
26	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
27	absent	absend	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
28	from	from	ADP	IN	_	_	_	_	_
29	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
30	large	large	ADJ	JJ	Degree=Pos	_	_	_	_
31	number	number	NOUN	NN	Number=Sing	_	_	_	_
32	of	of	ADP	IN	_	_	_	_	_
33	other	other	ADJ	JJ	Degree=Pos	_	_	_	_
34	hematologic	hematologic	ADJ	JJ	Degree=Pos	_	_	_	_
35	neoplasms	neoplasm	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
36	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2259
# text = These observations imply a T cell-specific function for TCF-1, a notion corroborated by recent observations on Tcf-1 knock-out mice.
1	These	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
2	observations	observation	NOUN	NNS	Number=Plur	_	_	_	_
3	imply	imply	ADV	RB	_	_	_	_	_
4	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
5	T	T	PROPN	NNP	Number=Sing	_	_	_	_
6	cell	cell	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
7	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
8	specific	specific	ADJ	JJ	Degree=Pos	_	_	_	_
9	function	function	NOUN	NN	Number=Sing	_	_	_	_
10	for	for	ADP	IN	_	_	_	_	_
11	TCF	TCF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
12	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
13	1	1	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
14	,	,	PUNCT	,	_	_	_	_	_
15	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
16	notion	notion	NOUN	NN	Number=Sing	_	_	_	_
17	corroborated	corroborate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
18	by	by	ADP	IN	_	_	_	_	_
19	recent	recent	ADJ	JJ	Degree=Pos	_	_	_	_
20	observations	observation	NOUN	NNS	Number=Plur	_	_	_	_
21	on	on	ADP	IN	_	_	_	_	_
22	Tcf	Tcf	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
23	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
24	1	1	NUM	CD	NumType=Card	_	_	_	_
25	knock	knock	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
26	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
27	out	out	NOUN	NN	Number=Sing	_	_	_	_
28	mice	mouse	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
29	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2260
# text = In addition, these results indicate that nuclear TCF-1 expression can serve as a pan-T-lineage marker in the diagnosis of lymphoid malignancies.
1	In	in	ADP	IN	_	_	_	_	_
2	addition	addition	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
3	,	,	PUNCT	,	_	_	_	_	_
4	these	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
5	results	result	NOUN	NNS	Number=Plur	_	_	_	_
6	indicate	indicate	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
7	that	that	SCONJ	IN	_	_	_	_	_
8	nuclear	nuclear	ADJ	JJ	Degree=Pos	_	_	_	_
9	TCF	Tcf	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
10	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
11	1	1	NUM	CD	NumType=Card	_	_	_	_
12	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
13	can	can	AUX	MD	VerbForm=Fin	_	_	_	_
14	serve	serve	VERB	VB	VerbForm=Inf	_	_	_	_
15	as	as	ADP	IN	_	_	_	_	_
16	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
17	pan-T	pan-t	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
18	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
19	lineage	lineage	NOUN	NN	Number=Sing	_	_	_	_
20	marker	marker	NOUN	NN	Number=Sing	_	_	_	_
21	in	in	ADP	IN	_	_	_	_	_
22	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
23	diagnosis	diagnosis	NOUN	NN	Number=Sing	_	_	_	_
24	of	of	ADP	IN	_	_	_	_	_
25	lymphoid	lymphoid	ADJ	JJ	Degree=Pos	_	_	_	_
26	malignancies	malignancy	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
27	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 2261
# text = Document 003003164 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	003003164	003003164	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 2262
# text = Transient pseudo-hypoaldosteronism following resection of the ileum: normal level of lymphocytic aldosterone receptors outside the acute phase.
1	Transient	Transient	ADJ	JJ	Degree=Pos	_	_	_	_
2	pseudo	pseudo	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
3	-hypoaldosteronism	-hypoaldosteronism	NOUN	NN	Number=Sing	_	_	_	_
4	following	follow	VERB	VBG	VerbForm=Ger	_	_	_	_
5	resection	resection	NOUN	NN	Number=Sing	_	_	_	_
6	of	of	ADP	IN	_	_	_	_	_
7	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
8	ileum	ileum	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
9	:	:	PUNCT	:	_	_	_	_	_
10	normal	normal	ADJ	JJ	Degree=Pos	_	_	_	_
11	level	level	NOUN	NN	Number=Sing	_	_	_	_
12	of	of	ADP	IN	_	_	_	_	_
13	lymphocytic	lymphocytic	ADJ	JJ	Degree=Pos	_	_	_	_
14	aldosterone	aldosterone	NOUN	NN	Number=Sing	_	_	_	_
15	receptors	receptor	NOUN	NNS	Number=Plur	_	_	_	_
16	outside	outside	ADP	IN	_	_	_	_	_
17	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
18	acute	acute	ADJ	JJ	Degree=Pos	_	_	_	_
19	phase	phase	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
20	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 2263
# text = Pseudo-hypoaldosteronism (PHA) is due to mineralocorticoid resistance and manifests as hyponatremia and hyperkalemia with increased plasma aldosterone levels.
1	Pseudo-hypoaldosteronism	Pseudo-hypoaldosteronism	PROPN	NNP	Number=Sing	_	_	_	_
2	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
3	PHA	PHA	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
4	)	)	PUNCT	-RRB-	_	_	_	_	_
5	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
6	due	due	ADP	IN	_	_	_	_	_
7	to	to	ADP	IN	_	_	_	_	_
8	mineralocorticoid	mineralocorticoid	NOUN	NN	Number=Sing	_	_	_	_
9	resistance	resistance	NOUN	NN	Number=Sing	_	_	_	_
10	and	and	CCONJ	CC	_	_	_	_	_
11	manifests	manifest	NOUN	NNS	Number=Plur	_	_	_	_
12	as	as	ADP	IN	_	_	_	_	_
13	hyponatremia	hyponatremion	NOUN	NN	Number=Sing	_	_	_	_
14	and	and	CCONJ	CC	_	_	_	_	_
15	hyperkalemia	hyperkalemion	NOUN	NN	Number=Sing	_	_	_	_
16	with	with	ADP	IN	_	_	_	_	_
17	increased	increase	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
18	plasma	plasma	NOUN	NN	Number=Sing	_	_	_	_
19	aldosterone	aldosterone	NOUN	NN	Number=Sing	_	_	_	_
20	levels	level	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
21	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2264
# text = It may be familial or secondary to abnormal renal sodium handling.
1	It	it	PRON	PRP	Case=Nom|Gender=Neut|Number=Sing|Person=3|PronType=Prs	_	_	_	_
2	may	may	AUX	MD	VerbForm=Fin	_	_	_	_
3	be	be	AUX	VB	VerbForm=Inf	_	_	_	_
4	familial	familial	ADJ	JJ	Degree=Pos	_	_	_	_
5	or	or	CCONJ	CC	_	_	_	_	_
6	secondary	secondary	ADJ	JJ	Degree=Pos	_	_	_	_
7	to	to	ADP	IN	_	_	_	_	_
8	abnormal	abnormal	ADJ	JJ	Degree=Pos	_	_	_	_
9	renal	renal	ADJ	JJ	Degree=Pos	_	_	_	_
10	sodium	sodium	NOUN	NN	Number=Sing	_	_	_	_
11	handling	handling	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
12	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2265
# text = We report the case of a 54-year-old woman with multifocal cancer of the colon, who developed PHA after subtotal colectomy, ileal resection and jejunostomy.
1	We	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
2	report	report	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
3	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
4	case	case	NOUN	NN	Number=Sing	_	_	_	_
5	of	of	ADP	IN	_	_	_	_	_
6	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
7	54	54	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
8	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
9	year	year	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
10	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
11	old	old	ADJ	JJ	Degree=Pos	_	_	_	_
12	woman	woman	NOUN	NN	Number=Sing	_	_	_	_
13	with	with	ADP	IN	_	_	_	_	_
14	multifocal	multifocal	ADJ	JJ	Degree=Pos	_	_	_	_
15	cancer	cancer	NOUN	NN	Number=Sing	_	_	_	_
16	of	of	ADP	IN	_	_	_	_	_
17	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
18	colon	colon	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
19	,	,	PUNCT	,	_	_	_	_	_
20	who	who	PRON	WP	PronType=Rel	_	_	_	_
21	developed	develope	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
22	PHA	PHA	PROPN	NNP	Number=Sing	_	_	_	_
23	after	after	ADP	IN	_	_	_	_	_
24	subtotal	subtotal	ADJ	JJ	Degree=Pos	_	_	_	_
25	colectomy	colectomy	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
26	,	,	PUNCT	,	_	_	_	_	_
27	ileal	ileal	ADJ	JJ	Degree=Pos	_	_	_	_
28	resection	resection	NOUN	NN	Number=Sing	_	_	_	_
29	and	and	CCONJ	CC	_	_	_	_	_
30	jejunostomy	jejunostomy	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
31	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2266
# text = She was treated with 6 g of salt daily to prevent dehydration, which she stopped herself because of reduced fecal losses.
1	She	she	PRON	PRP	Case=Nom|Gender=Fem|Number=Sing|Person=3|PronType=Prs	_	_	_	_
2	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
3	treated	treat	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
4	with	with	ADP	IN	_	_	_	_	_
5	6	6	NUM	CD	NumType=Card	_	_	_	_
6	g	g	NOUN	NN	Number=Sing	_	_	_	_
7	of	of	ADP	IN	_	_	_	_	_
8	salt	salt	NOUN	NN	Number=Sing	_	_	_	_
9	daily	daily	ADV	RB	_	_	_	_	_
10	to	to	PART	TO	_	_	_	_	_
11	prevent	prevent	VERB	VB	VerbForm=Inf	_	_	_	_
12	dehydration	dehydration	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
13	,	,	PUNCT	,	_	_	_	_	_
14	which	which	PRON	WDT	PronType=Rel	_	_	_	_
15	she	she	PRON	PRP	Case=Nom|Gender=Fem|Number=Sing|Person=3|PronType=Prs	_	_	_	_
16	stopped	stop	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
17	herself	herself	PRON	PRP	Case=Acc|Gender=Fem|Number=Sing|Person=3|PronType=Prs|Reflex=Yes	_	_	_	_
18	because	because	ADP	IN	_	_	_	_	_
19	of	of	ADP	IN	_	_	_	_	_
20	reduced	reduce	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
21	fecal	fecal	ADJ	JJ	Degree=Pos	_	_	_	_
22	losses	loss	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
23	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2267
# text = One month later she was admitted with signs of acute adrenal failure, i.e. fatigue, severe nausea, blood pressure of 80/60 mmHg, extracellular dehydration, hyponatremia (118 mmol/l); hyperkalemia (7.6 mmol/l), increased blood urea nitrogen (BUN) (200 mg/dl) and creatininemia (2.5 mg/dl), and decreased plasma bicarbonates level (HCO3-: 16 mmol/l; N: 27-30).
1	One	one	NUM	CD	NumType=Card	_	_	_	_
2	month	month	NOUN	NN	Number=Sing	_	_	_	_
3	later	later	ADV	RB	_	_	_	_	_
4	she	she	PRON	PRP	Case=Nom|Gender=Fem|Number=Sing|Person=3|PronType=Prs	_	_	_	_
5	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
6	admitted	admit	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
7	with	with	ADP	IN	_	_	_	_	_
8	signs	sign	NOUN	NNS	Number=Plur	_	_	_	_
9	of	of	ADP	IN	_	_	_	_	_
10	acute	acute	ADJ	JJ	Degree=Pos	_	_	_	_
11	adrenal	adrenal	ADJ	JJ	Degree=Pos	_	_	_	_
12	failure	failure	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
13	,	,	PUNCT	,	_	_	_	_	_
14	i.e.	i.e.	X	FW	_	_	_	_	_
15	fatigue	fatigue	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
16	,	,	PUNCT	,	_	_	_	_	_
17	severe	severe	ADJ	JJ	Degree=Pos	_	_	_	_
18	nausea	nausea	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
19	,	,	PUNCT	,	_	_	_	_	_
20	blood	blood	NOUN	NN	Number=Sing	_	_	_	_
21	pressure	pressure	NOUN	NN	Number=Sing	_	_	_	_
22	of	of	ADP	IN	_	_	_	_	_
23	80/60	80/60	NUM	CD	NumType=Card	_	_	_	_
24	mmHg	mmHg	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
25	,	,	PUNCT	,	_	_	_	_	_
26	extracellular	extracelular	ADJ	JJ	Degree=Pos	_	_	_	_
27	dehydration	dehydration	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
28	,	,	PUNCT	,	_	_	_	_	_
29	hyponatremia	hyponatremia	NOUN	NN	Number=Sing	_	_	_	_
30	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
31	118	118	NUM	CD	NumType=Card	_	_	_	_
32	mmol	mmol	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
33	/	/	PUNCT	,	_	_	_	_	SpaceAfter=No
34	l	l	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
35	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
36	;	;	PUNCT	,	_	_	_	_	_
37	hyperkalemia	hyperkalemia	NOUN	NN	Number=Sing	_	_	_	_
38	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
39	7.6	7.6	NUM	CD	NumType=Card	_	_	_	_
40	mmol/	mmol/	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
41	l	l	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
42	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
43	,	,	PUNCT	,	_	_	_	_	_
44	increased	increase	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
45	blood	blood	NOUN	NN	Number=Sing	_	_	_	_
46	urea	urea	NOUN	NN	Number=Sing	_	_	_	_
47	nitrogen	nitrogen	NOUN	NN	Number=Sing	_	_	_	_
48	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
49	BUN	bun	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
50	)	)	PUNCT	-RRB-	_	_	_	_	_
51	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
52	200	200	NUM	CD	NumType=Card	_	_	_	_
53	mg	mg	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
54	/	/	PUNCT	,	_	_	_	_	SpaceAfter=No
55	dl	dl	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
56	)	)	PUNCT	-RRB-	_	_	_	_	_
57	and	and	CCONJ	CC	_	_	_	_	_
58	creatininemia	creatininemia	NOUN	NN	Number=Sing	_	_	_	_
59	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
60	2.5	2.5	NUM	CD	NumType=Card	_	_	_	_
61	mg	mg	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
62	/dl	/dl	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
63	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
64	,	,	PUNCT	,	_	_	_	_	_
65	and	and	CCONJ	CC	_	_	_	_	_
66	decreased	decrease	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
67	plasma	plasma	NOUN	NN	Number=Sing	_	_	_	_
68	bicarbonates	bicarbonate	NOUN	NNS	Number=Plur	_	_	_	_
69	level	level	NOUN	NN	Number=Sing	_	_	_	_
70	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
71	HCO	HCo	INTJ	UH	_	_	_	_	SpaceAfter=No
72	3-:	3-:	PUNCT	,	_	_	_	_	_
73	16	16	NUM	CD	NumType=Card	_	_	_	_
74	mmol/l	mmol/l	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
75	;	;	PUNCT	,	_	_	_	_	_
76	N	and	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
77	:	:	PUNCT	:	_	_	_	_	_
78	27	27	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
79	-30	-30	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
80	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
81	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2268
# text = However, the plasma cortisol was high (66 microg/100 ml at 10:00 h; N: 8-15) and the ACTH was normal (13 pg/ml, N: 10-60); there was a marked increase in plasma renin activity (>37 ng/ml/h; N supine <3), active renin (869 pg/ml; N supine: 1.120), aldosterone (>2000 pg/ml; N supine <150) and plasma AVP (20 pmol/l; N: 0.5-2.5).
1	However	however	ADV	RB	_	_	_	_	SpaceAfter=No
2	,	,	PUNCT	,	_	_	_	_	_
3	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
4	plasma	plasma	NOUN	NN	Number=Sing	_	_	_	_
5	cortisol	cortisol	NOUN	NN	Number=Sing	_	_	_	_
6	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
7	high	high	ADJ	JJ	Degree=Pos	_	_	_	_
8	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
9	66	66	NUM	CD	NumType=Card	_	_	_	_
10	microg	microg	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
11	/100	/100	NUM	CD	NumType=Card	_	_	_	_
12	ml	ml	NOUN	NN	Number=Sing	_	_	_	_
13	at	at	ADP	IN	_	_	_	_	_
14	10:00	10:00	NUM	CD	NumType=Card	_	_	_	_
15	h	h	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
16	;	;	PUNCT	,	_	_	_	_	_
17	N	and	CCONJ	CC	Abbr=Yes	_	_	_	SpaceAfter=No
18	:	:	PUNCT	:	_	_	_	_	_
19	8	8	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
20	-	-	SYM	SYM	_	_	_	_	SpaceAfter=No
21	15	15	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
22	)	)	PUNCT	-RRB-	_	_	_	_	_
23	and	and	CCONJ	CC	_	_	_	_	_
24	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
25	ACTH	ACth	NOUN	NN	Number=Sing	_	_	_	_
26	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
27	normal	normal	ADJ	JJ	Degree=Pos	_	_	_	_
28	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
29	13	13	NUM	CD	NumType=Card	_	_	_	_
30	pg/ml	pg/ml	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
31	,	,	PUNCT	,	_	_	_	_	_
32	N	N	CCONJ	CC	Abbr=Yes	_	_	_	SpaceAfter=No
33	:	:	PUNCT	:	_	_	_	_	_
34	10	10	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
35	-60	-60	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
36	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
37	;	;	PUNCT	,	_	_	_	_	_
38	there	there	PRON	EX	_	_	_	_	_
39	was	be	VERB	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
40	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
41	marked	mark	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
42	increase	increase	NOUN	NN	Number=Sing	_	_	_	_
43	in	in	ADP	IN	_	_	_	_	_
44	plasma	plasma	NOUN	NN	Number=Sing	_	_	_	_
45	renin	renin	NOUN	NN	Number=Sing	_	_	_	_
46	activity	activity	NOUN	NN	Number=Sing	_	_	_	_
47	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
48	>37	>37	NUM	CD	NumType=Card	_	_	_	_
49	ng/ml/h	ng/ml/h	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
50	;	;	PUNCT	,	_	_	_	_	_
51	N	and	CCONJ	CC	Abbr=Yes	_	_	_	_
52	supine	supine	NOUN	NN	Number=Sing	_	_	_	_
53	<	<	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
54	3	3	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
55	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
56	,	,	PUNCT	,	_	_	_	_	_
57	active	active	ADJ	JJ	Degree=Pos	_	_	_	_
58	renin	renin	NOUN	NN	Number=Sing	_	_	_	_
59	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
60	869	869	NUM	CD	NumType=Card	_	_	_	_
61	pg	pg	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
62	/	/	PUNCT	,	_	_	_	_	SpaceAfter=No
63	ml	ml	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
64	;	;	PUNCT	,	_	_	_	_	_
65	N	and	CCONJ	CC	Abbr=Yes	_	_	_	_
66	supine	supine	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
67	:	:	PUNCT	:	_	_	_	_	_
68	1.120	1.120	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
69	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
70	,	,	PUNCT	,	_	_	_	_	_
71	aldosterone	aldosterone	NOUN	NN	Number=Sing	_	_	_	_
72	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
73	>2000	>2000	NUM	CD	NumType=Card	_	_	_	_
74	pg	pg	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
75	/	/	PUNCT	,	_	_	_	_	SpaceAfter=No
76	ml	ml	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
77	;	;	PUNCT	,	_	_	_	_	_
78	N	and	CCONJ	CC	Abbr=Yes	_	_	_	_
79	supine	supine	NOUN	NN	Number=Sing	_	_	_	_
80	<	<	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
81	150	150	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
82	)	)	PUNCT	-RRB-	_	_	_	_	_
83	and	and	CCONJ	CC	_	_	_	_	_
84	plasma	plasma	PROPN	NNP	Number=Sing	_	_	_	_
85	AVP	AVP	PROPN	NNP	Number=Sing	_	_	_	_
86	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
87	20	20	NUM	CD	NumType=Card	_	_	_	_
88	pmol/l	pmol/l	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
89	;	;	PUNCT	,	_	_	_	_	_
90	N	and	CCONJ	CC	Abbr=Yes	_	_	_	SpaceAfter=No
91	:	:	PUNCT	:	_	_	_	_	_
92	0.5	0.5	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
93	-	-	SYM	SYM	_	_	_	_	SpaceAfter=No
94	2.5	2.5	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
95	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
96	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2269
# text = The plasma ANH level was 38 pmol/l (N supine: 5-25).
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	plasma	plasma	NOUN	NN	Number=Sing	_	_	_	_
3	ANH	ANh	DET	DT	_	_	_	_	_
4	level	level	NOUN	NN	Number=Sing	_	_	_	_
5	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
6	38	38	NUM	CD	NumType=Card	_	_	_	_
7	pmol/	pmol/	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
8	l	l	NOUN	NN	Number=Sing	_	_	_	_
9	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
10	N	not	CCONJ	CC	Abbr=Yes	_	_	_	_
11	supine	supine	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
12	:	:	PUNCT	:	_	_	_	_	_
13	5	5	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
14	-	-	SYM	SYM	_	_	_	_	SpaceAfter=No
15	25	25	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
16	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
17	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2270
# text = A urinary steroidogram resulted in highly elevated tetrahydrocortisol (THF: 13.3 mg/24h; N: 1.4+/-0.8) with no increase in tetrahydrocortisone (THE: 3.16 mg/24h; N: 2.7+/-2.0) excretion, and with low THE/THF (0.24; N: 1.87+/-0.36) and alpha THF/THF (0.35; N: 0.92+/-0.42) ratios.
1	A	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
2	urinary	urinary	ADJ	JJ	Degree=Pos	_	_	_	_
3	steroidogram	steroidogram	NOUN	NN	Number=Sing	_	_	_	_
4	resulted	result	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
5	in	in	ADP	IN	_	_	_	_	_
6	highly	highly	ADV	RB	_	_	_	_	_
7	elevated	elevate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
8	tetrahydrocortisol	tetrahydrocortisol	NOUN	NN	Number=Sing	_	_	_	_
9	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
10	THF	Thf	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
11	:	:	PUNCT	:	_	_	_	_	_
12	13.3	13.3	NUM	CD	NumType=Card	_	_	_	_
13	mg/24h	mg/24h	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
14	;	;	PUNCT	,	_	_	_	_	_
15	N	and	CCONJ	CC	Abbr=Yes	_	_	_	SpaceAfter=No
16	:	:	PUNCT	:	_	_	_	_	_
17	1.4+/-	1.4+/-	SYM	SYM	_	_	_	_	SpaceAfter=No
18	0.8	0.8	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
19	)	)	PUNCT	-RRB-	_	_	_	_	_
20	with	with	ADP	IN	_	_	_	_	_
21	no	no	DET	DT	_	_	_	_	_
22	increase	increase	NOUN	NN	Number=Sing	_	_	_	_
23	in	in	ADP	IN	_	_	_	_	_
24	tetrahydrocortisone	tetrahydrocortisone	NOUN	NN	Number=Sing	_	_	_	_
25	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
26	THE	the	DET	DT	Definite=Def|PronType=Art	_	_	_	SpaceAfter=No
27	:	:	PUNCT	:	_	_	_	_	_
28	3.16	3.16	NUM	CD	NumType=Card	_	_	_	_
29	mg	mg	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
30	/24h	/24h	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
31	;	;	PUNCT	,	_	_	_	_	_
32	N	and	CCONJ	CC	Abbr=Yes	_	_	_	SpaceAfter=No
33	:	:	PUNCT	:	_	_	_	_	_
34	2.7+/-	2.7+/-	SYM	SYM	_	_	_	_	SpaceAfter=No
35	2.0	2.0	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
36	)	)	PUNCT	-RRB-	_	_	_	_	_
37	excretion	excretion	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
38	,	,	PUNCT	,	_	_	_	_	_
39	and	and	CCONJ	CC	_	_	_	_	_
40	with	with	ADP	IN	_	_	_	_	_
41	low	low	ADJ	JJ	Degree=Pos	_	_	_	_
42	THE	the	DET	DT	Definite=Def|PronType=Art	_	_	_	SpaceAfter=No
43	/	/	PUNCT	,	_	_	_	_	SpaceAfter=No
44	THF	Thf	NOUN	NN	Number=Sing	_	_	_	_
45	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
46	0.24	0.24	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
47	;	;	PUNCT	,	_	_	_	_	_
48	N	and	CCONJ	CC	Abbr=Yes	_	_	_	SpaceAfter=No
49	:	:	PUNCT	:	_	_	_	_	_
50	1.87+/-0.36	1.87+/-0.36	X	LS	_	_	_	_	SpaceAfter=No
51	)	)	PUNCT	-RRB-	_	_	_	_	_
52	and	and	CCONJ	CC	_	_	_	_	_
53	alpha	alpha	PROPN	NNP	Number=Sing	_	_	_	_
54	THF	THF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
55	/	/	PUNCT	,	_	_	_	_	SpaceAfter=No
56	THF	THF	PROPN	NNP	Number=Sing	_	_	_	_
57	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
58	0.35	0.35	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
59	;	;	PUNCT	,	_	_	_	_	_
60	N	and	CCONJ	CC	Abbr=Yes	_	_	_	SpaceAfter=No
61	:	:	PUNCT	:	_	_	_	_	_
62	0.92+/-	0.92+/-	SYM	SYM	_	_	_	_	SpaceAfter=No
63	0.42	0.42	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
64	)	)	PUNCT	-RRB-	_	_	_	_	_
65	ratios	ratio	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
66	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2271
# text = The number of mineralocorticoid receptors in mononuclear leukocytes was in the lower normal range for age, while the number of glucocorticoid receptors was reduced.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	number	number	NOUN	NN	Number=Sing	_	_	_	_
3	of	of	ADP	IN	_	_	_	_	_
4	mineralocorticoid	mineralocorticoid	ADJ	JJ	Degree=Pos	_	_	_	_
5	receptors	receptor	NOUN	NNS	Number=Plur	_	_	_	_
6	in	in	ADP	IN	_	_	_	_	_
7	mononuclear	mononuclear	ADJ	JJ	Degree=Pos	_	_	_	_
8	leukocytes	leukocyte	NOUN	NNS	Number=Plur	_	_	_	_
9	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
10	in	in	ADP	IN	_	_	_	_	_
11	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
12	lower	lower	ADJ	JJR	Degree=Cmp	_	_	_	_
13	normal	normal	ADJ	JJ	Degree=Pos	_	_	_	_
14	range	range	NOUN	NN	Number=Sing	_	_	_	_
15	for	for	ADP	IN	_	_	_	_	_
16	age	age	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
17	,	,	PUNCT	,	_	_	_	_	_
18	while	while	SCONJ	IN	_	_	_	_	_
19	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
20	number	number	NOUN	NN	Number=Sing	_	_	_	_
21	of	of	ADP	IN	_	_	_	_	_
22	glucocorticoid	glucocorticoid	ADJ	JJ	Degree=Pos	_	_	_	_
23	receptors	receptor	NOUN	NNS	Number=Plur	_	_	_	_
24	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
25	reduced	reduce	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	SpaceAfter=No
26	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2272
# text = Small-bowel resection in ileostomized patients causes excessive fecal sodium losses and results in chronic sodium depletion with contraction of the plasma volume and severe secondary hyperaldosteronism.
1	Small	small	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
2	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
3	bowel	bowel	NOUN	NN	Number=Sing	_	_	_	_
4	resection	resection	NOUN	NN	Number=Sing	_	_	_	_
5	in	in	ADP	IN	_	_	_	_	_
6	ileostomized	ileostomize	ADJ	JJ	Degree=Pos	_	_	_	_
7	patients	patient	NOUN	NNS	Number=Plur	_	_	_	_
8	causes	cause	NOUN	NNS	Number=Plur	_	_	_	_
9	excessive	excessive	ADJ	JJ	Degree=Pos	_	_	_	_
10	fecal	fecal	ADJ	JJ	Degree=Pos	_	_	_	_
11	sodium	sodium	NOUN	NN	Number=Sing	_	_	_	_
12	losses	loss	NOUN	NNS	Number=Plur	_	_	_	_
13	and	and	CCONJ	CC	_	_	_	_	_
14	results	result	NOUN	NNS	Number=Plur	_	_	_	_
15	in	in	ADP	IN	_	_	_	_	_
16	chronic	chronic	ADJ	JJ	Degree=Pos	_	_	_	_
17	sodium	sodium	NOUN	NN	Number=Sing	_	_	_	_
18	depletion	depletion	NOUN	NN	Number=Sing	_	_	_	_
19	with	with	ADP	IN	_	_	_	_	_
20	contraction	contraction	NOUN	NN	Number=Sing	_	_	_	_
21	of	of	ADP	IN	_	_	_	_	_
22	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
23	plasma	plasma	NOUN	NN	Number=Sing	_	_	_	_
24	volume	volume	NOUN	NN	Number=Sing	_	_	_	_
25	and	and	CCONJ	CC	_	_	_	_	_
26	severe	severe	ADJ	JJ	Degree=Pos	_	_	_	_
27	secondary	secondary	ADJ	JJ	Degree=Pos	_	_	_	_
28	hyperaldosteronism	hyperaldosteronism	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
29	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2273
# text = Nevertheless, this hyperaldosteronism may be associated with hyponatremia and hyperkalemia suggesting PHA related to the major importance of the colon for the absorption of sodium.
1	Nevertheless	nevertheless	ADV	RB	_	_	_	_	SpaceAfter=No
2	,	,	PUNCT	,	_	_	_	_	_
3	this	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
4	hyperaldosteronism	hyperaldosteronism	NOUN	NN	Number=Sing	_	_	_	_
5	may	may	AUX	MD	VerbForm=Fin	_	_	_	_
6	be	be	AUX	VB	VerbForm=Inf	_	_	_	_
7	associated	associate	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
8	with	with	ADP	IN	_	_	_	_	_
9	hyponatremia	hyponatremia	NOUN	NN	Number=Sing	_	_	_	_
10	and	and	CCONJ	CC	_	_	_	_	_
11	hyperkalemia	hyperkalemia	NOUN	NN	Number=Sing	_	_	_	_
12	suggesting	suggest	VERB	VBG	VerbForm=Ger	_	_	_	_
13	PHA	Pha	PROPN	NNP	Number=Sing	_	_	_	_
14	related	related	ADJ	JJ	Degree=Pos	_	_	_	_
15	to	to	ADP	IN	_	_	_	_	_
16	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
17	major	major	ADJ	JJ	Degree=Pos	_	_	_	_
18	importance	importance	NOUN	NN	Number=Sing	_	_	_	_
19	of	of	ADP	IN	_	_	_	_	_
20	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
21	colon	colon	NOUN	NN	Number=Sing	_	_	_	_
22	for	for	ADP	IN	_	_	_	_	_
23	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
24	absorption	absorption	NOUN	NN	Number=Sing	_	_	_	_
25	of	of	ADP	IN	_	_	_	_	_
26	sodium	sodium	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
27	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2274
# text = In conclusion, this case report emphasizes 1) the possibility of a syndrome of acquired PHA with severe hyperkalemia after resection of the ileum and colon responding to oral salt supplementation; 2) the major increase in AVP and the small increase in ANH; 3) the strong increase in urinary THF with low THE/THF and alpha THF/THF ratios; 4) the normal number of lymphocytic mineralocorticoid receptors outside the acute episode.
1	In	in	ADP	IN	_	_	_	_	_
2	conclusion	conclusion	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
3	,	,	PUNCT	,	_	_	_	_	_
4	this	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
5	case	case	NOUN	NN	Number=Sing	_	_	_	_
6	report	report	NOUN	NN	Number=Sing	_	_	_	_
7	emphasizes	emphasize	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
8	1	1	X	LS	_	_	_	_	SpaceAfter=No
9	)	)	PUNCT	-RRB-	_	_	_	_	_
10	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
11	possibility	possibility	NOUN	NN	Number=Sing	_	_	_	_
12	of	of	ADP	IN	_	_	_	_	_
13	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
14	syndrome	syndrome	NOUN	NN	Number=Sing	_	_	_	_
15	of	of	ADP	IN	_	_	_	_	_
16	acquired	acquired	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
17	PHA	PHa	NOUN	NN	Number=Sing	_	_	_	_
18	with	with	ADP	IN	_	_	_	_	_
19	severe	severe	ADJ	JJ	Degree=Pos	_	_	_	_
20	hyperkalemia	hyperkalemia	NOUN	NN	Number=Sing	_	_	_	_
21	after	after	ADP	IN	_	_	_	_	_
22	resection	resection	NOUN	NN	Number=Sing	_	_	_	_
23	of	of	ADP	IN	_	_	_	_	_
24	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
25	ileum	ileum	NOUN	NN	Number=Sing	_	_	_	_
26	and	and	CCONJ	CC	_	_	_	_	_
27	colon	colon	NOUN	NN	Number=Sing	_	_	_	_
28	responding	respond	VERB	VBG	VerbForm=Ger	_	_	_	_
29	to	to	ADP	IN	_	_	_	_	_
30	oral	oral	ADJ	JJ	Degree=Pos	_	_	_	_
31	salt	salt	NOUN	NN	Number=Sing	_	_	_	_
32	supplementation	supplementation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
33	;	;	PUNCT	,	_	_	_	_	_
34	2	2	X	LS	_	_	_	_	SpaceAfter=No
35	)	)	PUNCT	-RRB-	_	_	_	_	_
36	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
37	major	major	ADJ	JJ	Degree=Pos	_	_	_	_
38	increase	increase	NOUN	NN	Number=Sing	_	_	_	_
39	in	in	ADP	IN	_	_	_	_	_
40	AVP	AVP	PROPN	NNP	Number=Sing	_	_	_	_
41	and	and	CCONJ	CC	_	_	_	_	_
42	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
43	small	small	ADJ	JJ	Degree=Pos	_	_	_	_
44	increase	increase	NOUN	NN	Number=Sing	_	_	_	_
45	in	in	ADP	IN	_	_	_	_	_
46	ANH	ANH	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
47	;	;	PUNCT	,	_	_	_	_	_
48	3	3	X	LS	_	_	_	_	SpaceAfter=No
49	)	)	PUNCT	-RRB-	_	_	_	_	_
50	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
51	strong	strong	ADJ	JJ	Degree=Pos	_	_	_	_
52	increase	increase	NOUN	NN	Number=Sing	_	_	_	_
53	in	in	ADP	IN	_	_	_	_	_
54	urinary	urinary	ADJ	JJ	Degree=Pos	_	_	_	_
55	THF	Thf	NOUN	NN	Number=Sing	_	_	_	_
56	with	with	ADP	IN	_	_	_	_	_
57	low	low	ADJ	JJ	Degree=Pos	_	_	_	_
58	THE	the	DET	DT	Definite=Def|PronType=Art	_	_	_	SpaceAfter=No
59	/	/	PUNCT	,	_	_	_	_	SpaceAfter=No
60	THF	THF	PROPN	NNP	Number=Sing	_	_	_	_
61	and	and	CCONJ	CC	_	_	_	_	_
62	alpha	alpha	PROPN	NNP	Number=Sing	_	_	_	_
63	THF	THF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
64	/	/	PUNCT	,	_	_	_	_	SpaceAfter=No
65	THF	Thf	NOUN	NN	Number=Sing	_	_	_	_
66	ratios	ratio	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
67	;	;	PUNCT	,	_	_	_	_	_
68	4	4	X	LS	_	_	_	_	SpaceAfter=No
69	)	)	PUNCT	-RRB-	_	_	_	_	_
70	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
71	normal	normal	ADJ	JJ	Degree=Pos	_	_	_	_
72	number	number	NOUN	NN	Number=Sing	_	_	_	_
73	of	of	ADP	IN	_	_	_	_	_
74	lymphocytic	lymphocytic	ADJ	JJ	Degree=Pos	_	_	_	_
75	mineralocorticoid	mineralocorticoid	NOUN	NN	Number=Sing	_	_	_	_
76	receptors	receptor	NOUN	NNS	Number=Plur	_	_	_	_
77	outside	outside	ADP	IN	_	_	_	_	_
78	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
79	acute	acute	ADJ	JJ	Degree=Pos	_	_	_	_
80	episode	episode	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
81	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 2275
# text = Document 003003169 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	003003169	003003169	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 2276
# text = Genetic evidence for an additional factor required for erythropoietin-induced signal transduction.
1	Genetic	genetic	ADJ	JJ	Degree=Pos	_	_	_	_
2	evidence	evidence	NOUN	NN	Number=Sing	_	_	_	_
3	for	for	ADP	IN	_	_	_	_	_
4	an	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
5	additional	additional	ADJ	JJ	Degree=Pos	_	_	_	_
6	factor	factor	NOUN	NN	Number=Sing	_	_	_	_
7	required	require	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
8	for	for	ADP	IN	_	_	_	_	_
9	erythropoietin	erythropoietin	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	SpaceAfter=No
10	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
11	induced	induce	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
12	signal	signal	NOUN	NN	Number=Sing	_	_	_	_
13	transduction	transduction	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
14	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 2277
# text = Erythropoietin (EPO) and its receptor (EPOR) are required for the development of mature erythrocytes.
1	Erythropoietin	Erythropoietin	PROPN	NNP	Number=Sing	_	_	_	_
2	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
3	EPO	EPO	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
4	)	)	PUNCT	-RRB-	_	_	_	_	_
5	and	and	CCONJ	CC	_	_	_	_	_
6	its	its	PRON	PRP$	Gender=Neut|Number=Sing|Person=3|Poss=Yes|PronType=Prs	_	_	_	_
7	receptor	receptor	NOUN	NN	Number=Sing	_	_	_	_
8	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
9	EPOR	Epor	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
10	)	)	PUNCT	-RRB-	_	_	_	_	_
11	are	be	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
12	required	require	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
13	for	for	ADP	IN	_	_	_	_	_
14	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
15	development	development	NOUN	NN	Number=Sing	_	_	_	_
16	of	of	ADP	IN	_	_	_	_	_
17	mature	mature	ADJ	JJ	Degree=Pos	_	_	_	_
18	erythrocytes	erythrocyte	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
19	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2278
# text = After binding of ligand, the EPOR activates a variety of signaling pathways that ultimately control cellular proliferation, survival, and specific gene expression.
1	After	after	SCONJ	IN	_	_	_	_	_
2	binding	bind	VERB	VBG	VerbForm=Ger	_	_	_	_
3	of	of	ADP	IN	_	_	_	_	_
4	ligand	ligand	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
5	,	,	PUNCT	,	_	_	_	_	_
6	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
7	EPOR	Epor	PROPN	NNP	Number=Sing	_	_	_	_
8	activates	activate	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
9	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
10	variety	variety	NOUN	NN	Number=Sing	_	_	_	_
11	of	of	ADP	IN	_	_	_	_	_
12	signaling	signaling	NOUN	NN	Number=Sing	_	_	_	_
13	pathways	pathway	NOUN	NNS	Number=Plur	_	_	_	_
14	that	that	PRON	WDT	PronType=Rel	_	_	_	_
15	ultimately	ultimately	ADV	RB	_	_	_	_	_
16	control	control	VERB	VB	VerbForm=Inf	_	_	_	_
17	cellular	cellular	ADJ	JJ	Degree=Pos	_	_	_	_
18	proliferation	proliferation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
19	,	,	PUNCT	,	_	_	_	_	_
20	survival	survival	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
21	,	,	PUNCT	,	_	_	_	_	_
22	and	and	CCONJ	CC	_	_	_	_	_
23	specific	specific	ADJ	JJ	Degree=Pos	_	_	_	_
24	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
25	expression	expression	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
26	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2279
# text = Although erythroid progenitors appear to be the principal EPO-responsive cell type in vivo due to the restricted expression of the EPOR, many growth factor-dependent cell lines expressing the EPOR can respond to EPO by activating many or all of these pathways.
1	Although	although	SCONJ	IN	_	_	_	_	_
2	erythroid	erythroid	ADJ	JJ	Degree=Pos	_	_	_	_
3	progenitors	progenitor	NOUN	NNS	Number=Plur	_	_	_	_
4	appear	appear	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
5	to	to	PART	TO	_	_	_	_	_
6	be	be	AUX	VB	VerbForm=Inf	_	_	_	_
7	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
8	principal	principal	NOUN	NN	Number=Sing	_	_	_	_
9	EPO	Epo	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
10	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
11	responsive	responsive	ADJ	JJ	Degree=Pos	_	_	_	_
12	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
13	type	type	NOUN	NN	Number=Sing	_	_	_	_
14	in	in	ADP	IN	_	_	_	_	_
15	vivo	vivo	NOUN	NN	Number=Sing	_	_	_	_
16	due	due	ADP	IN	_	_	_	_	_
17	to	to	ADP	IN	_	_	_	_	_
18	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
19	restricted	restrict	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
20	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
21	of	of	ADP	IN	_	_	_	_	_
22	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
23	EPOR	Epor	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
24	,	,	PUNCT	,	_	_	_	_	_
25	many	many	ADJ	JJ	Degree=Pos	_	_	_	_
26	growth	growth	NOUN	NN	Number=Sing	_	_	_	_
27	factor	factor	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
28	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
29	dependent	dependent	ADJ	JJ	Degree=Pos	_	_	_	_
30	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
31	lines	line	NOUN	NNS	Number=Plur	_	_	_	_
32	expressing	expresse	VERB	VBG	VerbForm=Ger	_	_	_	_
33	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
34	EPOR	Epor	NOUN	NN	Number=Sing	_	_	_	_
35	can	can	AUX	MD	VerbForm=Fin	_	_	_	_
36	respond	respond	VERB	VB	VerbForm=Inf	_	_	_	_
37	to	to	ADP	IN	_	_	_	_	_
38	EPO	EPO	PROPN	NNP	Number=Sing	_	_	_	_
39	by	by	SCONJ	IN	_	_	_	_	_
40	activating	activat	VERB	VBG	VerbForm=Ger	_	_	_	_
41	many	many	ADJ	JJ	Degree=Pos	_	_	_	_
42	or	or	CCONJ	CC	_	_	_	_	_
43	all	all	DET	DT	_	_	_	_	_
44	of	of	ADP	IN	_	_	_	_	_
45	these	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
46	pathways	pathway	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
47	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2280
# text = In the present study, we have identified a cellular context (the interleukin-2 [IL-2]-dependent HT-2 line) in which the EPO stimulation of the EPOR fails to support cellular proliferation, STAT-5 induction, or MAPK activation, despite efficient phosphorylation of the EPOR and JAK2 and inhibition of apoptosis after withdrawal of IL-2.
1	In	in	ADP	IN	_	_	_	_	_
2	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
3	present	present	ADJ	JJ	Degree=Pos	_	_	_	_
4	study	study	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
5	,	,	PUNCT	,	_	_	_	_	_
6	we	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
7	have	have	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
8	identified	identify	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
9	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
10	cellular	cellular	ADJ	JJ	Degree=Pos	_	_	_	_
11	context	context	NOUN	NN	Number=Sing	_	_	_	_
12	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
13	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
14	interleukin	interleukin	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
15	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
16	2	2	NUM	CD	NumType=Card	_	_	_	_
17	[	[	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
18	IL	Il	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
19	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
20	2	2	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
21	]	]	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
22	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
23	dependent	dependent	ADJ	JJ	Degree=Pos	_	_	_	_
24	HT	Ht	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
25	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
26	2	2	NUM	CD	NumType=Card	_	_	_	_
27	line	line	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
28	)	)	PUNCT	-RRB-	_	_	_	_	_
29	in	in	ADP	IN	_	_	_	_	_
30	which	which	PRON	WDT	PronType=Rel	_	_	_	_
31	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
32	EPO	EPO	PROPN	NNP	Number=Sing	_	_	_	_
33	stimulation	stimulation	NOUN	NN	Number=Sing	_	_	_	_
34	of	of	ADP	IN	_	_	_	_	_
35	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
36	EPOR	EPOR	PROPN	NNP	Number=Sing	_	_	_	_
37	fails	fail	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
38	to	to	PART	TO	_	_	_	_	_
39	support	support	VERB	VB	VerbForm=Inf	_	_	_	_
40	cellular	celular	ADJ	JJ	Degree=Pos	_	_	_	_
41	proliferation	proliferation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
42	,	,	PUNCT	,	_	_	_	_	_
43	STAT	Stat	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
44	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
45	5	5	NUM	CD	NumType=Card	_	_	_	_
46	induction	induction	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
47	,	,	PUNCT	,	_	_	_	_	_
48	or	or	CCONJ	CC	_	_	_	_	_
49	MAPK	MAPK	PROPN	NNP	Number=Sing	_	_	_	_
50	activation	activation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
51	,	,	PUNCT	,	_	_	_	_	_
52	despite	despite	ADP	IN	_	_	_	_	_
53	efficient	efficient	ADJ	JJ	Degree=Pos	_	_	_	_
54	phosphorylation	phosphorylation	NOUN	NN	Number=Sing	_	_	_	_
55	of	of	ADP	IN	_	_	_	_	_
56	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
57	EPOR	Epor	NOUN	NN	Number=Sing	_	_	_	_
58	and	and	CCONJ	CC	_	_	_	_	_
59	JAK2	Jak2	NOUN	NN	Number=Sing	_	_	_	_
60	and	and	CCONJ	CC	_	_	_	_	_
61	inhibition	inhibition	NOUN	NN	Number=Sing	_	_	_	_
62	of	of	ADP	IN	_	_	_	_	_
63	apoptosis	apoptosis	NOUN	NN	Number=Sing	_	_	_	_
64	after	after	ADP	IN	_	_	_	_	_
65	withdrawal	withdrawal	NOUN	NN	Number=Sing	_	_	_	_
66	of	of	ADP	IN	_	_	_	_	_
67	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
68	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
69	2	2	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
70	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2281
# text = Interestingly, when we fused HT-2 cells expressing the EPOR with Ba/F3 cells in a complementation assay, the resulting hybridomas proliferated and potently activated STAT-5 and MAPK in response to EPO.
1	Interestingly	Interestingly	ADV	RB	_	_	_	_	SpaceAfter=No
2	,	,	PUNCT	,	_	_	_	_	_
3	when	when	ADV	WRB	PronType=Int	_	_	_	_
4	we	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
5	fused	fuse	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
6	HT	HT	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
7	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
8	2	2	NUM	CD	NumType=Card	_	_	_	_
9	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
10	expressing	express	VERB	VBG	VerbForm=Ger	_	_	_	_
11	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
12	EPOR	Epor	NOUN	NN	Number=Sing	_	_	_	_
13	with	with	ADP	IN	_	_	_	_	_
14	Ba/F3	Ba/F3	NUM	CD	NumType=Card	_	_	_	_
15	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
16	in	in	ADP	IN	_	_	_	_	_
17	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
18	complementation	complementation	NOUN	NN	Number=Sing	_	_	_	_
19	assay	assay	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
20	,	,	PUNCT	,	_	_	_	_	_
21	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
22	resulting	result	VERB	VBG	VerbForm=Ger	_	_	_	_
23	hybridomas	hybridoma	NOUN	NNS	Number=Plur	_	_	_	_
24	proliferated	proliferate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
25	and	and	CCONJ	CC	_	_	_	_	_
26	potently	potently	ADV	RB	_	_	_	_	_
27	activated	activate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
28	STAT	STAT	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
29	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
30	5	5	NUM	CD	NumType=Card	_	_	_	_
31	and	and	CCONJ	CC	_	_	_	_	_
32	MAPK	MAPK	PROPN	NNP	Number=Sing	_	_	_	_
33	in	in	ADP	IN	_	_	_	_	_
34	response	response	NOUN	NN	Number=Sing	_	_	_	_
35	to	to	ADP	IN	_	_	_	_	_
36	EPO	EPO	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
37	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2282
# text = These data indicate that an unidentified cellular factor is needed to mediate signaling by the EPOR.
1	These	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
2	data	data	NOUN	NN	Number=Sing	_	_	_	_
3	indicate	indicate	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
4	that	that	SCONJ	IN	_	_	_	_	_
5	an	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
6	unidentified	unidentified	ADJ	JJ	Degree=Pos	_	_	_	_
7	cellular	cellular	NOUN	NN	Number=Sing	_	_	_	_
8	factor	factor	NOUN	NN	Number=Sing	_	_	_	_
9	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
10	needed	need	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
11	to	to	PART	TO	_	_	_	_	_
12	mediate	mediate	VERB	VB	VerbForm=Inf	_	_	_	_
13	signaling	signal	VERB	VBG	VerbForm=Ger	_	_	_	_
14	by	by	ADP	IN	_	_	_	_	_
15	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
16	EPOR	Epor	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
17	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2283
# text = Moreover, Ba/F3 cells apparently express this factor(s) and somatic fusions can, therefore, confer EPO-responsiveness to HT-2 cells that lack this factor.
1	Moreover	moreover	ADV	RB	_	_	_	_	SpaceAfter=No
2	,	,	PUNCT	,	_	_	_	_	_
3	Ba/F3	Ba/F3	NUM	CD	NumType=Card	_	_	_	_
4	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
5	apparently	apparently	ADV	RB	_	_	_	_	_
6	express	express	VERB	VB	Mood=Imp|VerbForm=Fin	_	_	_	_
7	this	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
8	factor	factor	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
9	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
10	s	s	X	AFX	_	_	_	_	SpaceAfter=No
11	)	)	PUNCT	-RRB-	_	_	_	_	_
12	and	and	CCONJ	CC	_	_	_	_	_
13	somatic	somatic	ADJ	JJ	Degree=Pos	_	_	_	_
14	fusions	fusion	NOUN	NNS	Number=Plur	_	_	_	_
15	can	can	AUX	MD	VerbForm=Fin	_	_	_	SpaceAfter=No
16	,	,	PUNCT	,	_	_	_	_	_
17	therefore	therefore	ADV	RB	_	_	_	_	SpaceAfter=No
18	,	,	PUNCT	,	_	_	_	_	_
19	confer	confer	VERB	VB	Mood=Imp|VerbForm=Fin	_	_	_	_
20	EPO	Epo	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
21	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
22	responsiveness	responsiveness	NOUN	NN	Number=Sing	_	_	_	_
23	to	to	ADP	IN	_	_	_	_	_
24	HT	HT	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
25	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
26	2	2	NUM	CD	NumType=Card	_	_	_	_
27	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
28	that	that	PRON	WDT	PronType=Rel	_	_	_	_
29	lack	lack	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
30	this	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
31	factor	factor	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
32	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 2284
# text = Document 003003171 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	003003171	003003171	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 2285
# text = Interleukin-7 can induce the activation of Jak 1, Jak 3 and STAT 5 proteins in murine T cells.
1	Interleukin	Interleukin	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
2	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
3	7	7	NUM	CD	NumType=Card	_	_	_	_
4	can	can	AUX	MD	VerbForm=Fin	_	_	_	_
5	induce	induce	VERB	VB	VerbForm=Inf	_	_	_	_
6	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
7	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
8	of	of	ADP	IN	_	_	_	_	_
9	Jak	Jak	PROPN	NNP	Number=Sing	_	_	_	_
10	1	1	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
11	,	,	PUNCT	,	_	_	_	_	_
12	Jak	Jak	PROPN	NNP	Number=Sing	_	_	_	_
13	3	3	NUM	CD	NumType=Card	_	_	_	_
14	and	and	CCONJ	CC	_	_	_	_	_
15	STAT	Stat	VERB	VB	VerbForm=Inf	_	_	_	_
16	5	5	NUM	CD	NumType=Card	_	_	_	_
17	proteins	protein	NOUN	NNS	Number=Plur	_	_	_	_
18	in	in	ADP	IN	_	_	_	_	_
19	murine	murine	ADJ	JJ	Degree=Pos	_	_	_	_
20	T	t	PROPN	NNP	Number=Sing	_	_	_	_
21	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
22	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 2286
# text = The activation of Janus protein tyrosine kinases (Jak) and STAT (signal transducer and activator of transcription) proteins has recently been linked to the signal transduction mechanism of several cytokines.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
3	of	of	ADP	IN	_	_	_	_	_
4	Janus	Janus	PROPN	NNP	Number=Sing	_	_	_	_
5	protein	protein	NOUN	NN	Number=Sing	_	_	_	_
6	tyrosine	tyrosine	NOUN	NN	Number=Sing	_	_	_	_
7	kinases	kinase	NOUN	NNS	Number=Plur	_	_	_	_
8	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
9	Jak	Jak	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
10	)	)	PUNCT	-RRB-	_	_	_	_	_
11	and	and	CCONJ	CC	_	_	_	_	_
12	STAT	STAT	NOUN	NN	Number=Sing	_	_	_	_
13	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
14	signal	signal	NOUN	NN	Number=Sing	_	_	_	_
15	transducer	transducer	NOUN	NN	Number=Sing	_	_	_	_
16	and	and	CCONJ	CC	_	_	_	_	_
17	activator	activator	NOUN	NN	Number=Sing	_	_	_	_
18	of	of	ADP	IN	_	_	_	_	_
19	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
20	)	)	PUNCT	-RRB-	_	_	_	_	_
21	proteins	protein	NOUN	NNS	Number=Plur	_	_	_	_
22	has	have	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
23	recently	recently	ADV	RB	_	_	_	_	_
24	been	be	AUX	VBN	Tense=Past|VerbForm=Part	_	_	_	_
25	linked	link	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
26	to	to	ADP	IN	_	_	_	_	_
27	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
28	signal	signal	NOUN	NN	Number=Sing	_	_	_	_
29	transduction	transduction	NOUN	NN	Number=Sing	_	_	_	_
30	mechanism	mechanism	NOUN	NN	Number=Sing	_	_	_	_
31	of	of	ADP	IN	_	_	_	_	_
32	several	several	ADJ	JJ	Degree=Pos	_	_	_	_
33	cytokines	cytokine	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
34	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2287
# text = IL-7 was observed to induce a rapid and dose-dependent tyrosine phosphorylation of Jak 1 and Jak 3 and concomitantly, the tyrosine phosphorylation and DNA binding activity of multiple
1	IL	Il	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
2	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
3	7	7	NUM	CD	NumType=Card	_	_	_	_
4	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
5	observed	observe	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
6	to	to	PART	TO	_	_	_	_	_
7	induce	induce	VERB	VB	VerbForm=Inf	_	_	_	_
8	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
9	rapid	rapid	NOUN	NN	Number=Sing	_	_	_	_
10	and	and	CCONJ	CC	_	_	_	_	_
11	dose	dose	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
12	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
13	dependent	dependent	ADJ	JJ	Degree=Pos	_	_	_	_
14	tyrosine	tyrosine	NOUN	NN	Number=Sing	_	_	_	_
15	phosphorylation	phosphorylation	NOUN	NN	Number=Sing	_	_	_	_
16	of	of	ADP	IN	_	_	_	_	_
17	Jak	Jak	PROPN	NNP	Number=Sing	_	_	_	_
18	1	1	NUM	CD	NumType=Card	_	_	_	_
19	and	and	CCONJ	CC	_	_	_	_	_
20	Jak	Jak	PROPN	NNP	Number=Sing	_	_	_	_
21	3	3	NUM	CD	NumType=Card	_	_	_	_
22	and	and	CCONJ	CC	_	_	_	_	_
23	concomitantly	concomitantly	ADV	RB	_	_	_	_	SpaceAfter=No
24	,	,	PUNCT	,	_	_	_	_	_
25	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
26	tyrosine	tyrosine	NOUN	NN	Number=Sing	_	_	_	_
27	phosphorylation	phosphorylation	NOUN	NN	Number=Sing	_	_	_	_
28	and	and	CCONJ	CC	_	_	_	_	_
29	DNA	dna	NOUN	NN	Number=Sing	_	_	_	_
30	binding	bind	VERB	VBG	VerbForm=Ger	_	_	_	_
31	activity	activity	NOUN	NN	Number=Sing	_	_	_	_
32	of	of	ADP	IN	_	_	_	_	_
33	multiple	multiple	ADJ	JJ	Degree=Pos	_	_	_	_

# sent_id = 2288
# text = STAT proteins.
1	STAT	Stat	ADJ	JJ	Degree=Pos	_	_	_	_
2	proteins	protein	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
3	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2289
# text = The
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_

# sent_id = 2290
# text = STAT proteins utilized by IL-7 were identical to those induced by IL-2 and could be identified as various STAT 5 isoforms.
1	STAT	Stat	ADJ	JJ	Degree=Pos	_	_	_	_
2	proteins	protein	NOUN	NNS	Number=Plur	_	_	_	_
3	utilized	utilize	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
4	by	by	ADP	IN	_	_	_	_	_
5	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
6	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
7	7	7	NUM	CD	NumType=Card	_	_	_	_
8	were	be	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
9	identical	identical	ADJ	JJ	Degree=Pos	_	_	_	_
10	to	to	ADP	IN	_	_	_	_	_
11	those	those	PRON	DT	Number=Plur|PronType=Dem	_	_	_	_
12	induced	induce	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
13	by	by	ADP	IN	_	_	_	_	_
14	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
15	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
16	2	2	NUM	CD	NumType=Card	_	_	_	_
17	and	and	CCONJ	CC	_	_	_	_	_
18	could	could	AUX	MD	VerbForm=Fin	_	_	_	_
19	be	be	AUX	VB	VerbForm=Inf	_	_	_	_
20	identified	identify	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
21	as	as	ADP	IN	_	_	_	_	_
22	various	various	ADJ	JJ	Degree=Pos	_	_	_	_
23	STAT	Stat	NOUN	NN	Number=Sing	_	_	_	_
24	5	5	NUM	CD	NumType=Card	_	_	_	_
25	isoforms	isoform	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
26	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2291
# text = Moreover, the induction of both Jak 1 and 3, and STAT 5 activity strongly correlated with the growth-promoting effects of IL-7, suggesting that this signal transduction mechanism may play a key role in IL-7-induced proliferation.
1	Moreover	moreover	ADV	RB	_	_	_	_	SpaceAfter=No
2	,	,	PUNCT	,	_	_	_	_	_
3	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
4	induction	induction	NOUN	NN	Number=Sing	_	_	_	_
5	of	of	ADP	IN	_	_	_	_	_
6	both	both	DET	DT	_	_	_	_	_
7	Jak	Jak	PROPN	NNP	Number=Sing	_	_	_	_
8	1	1	NUM	CD	NumType=Card	_	_	_	_
9	and	and	CCONJ	CC	_	_	_	_	_
10	3	3	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
11	,	,	PUNCT	,	_	_	_	_	_
12	and	and	CCONJ	CC	_	_	_	_	_
13	STAT	Stat	VERB	VB	Mood=Imp|VerbForm=Fin	_	_	_	_
14	5	5	NUM	CD	NumType=Card	_	_	_	_
15	activity	activity	NOUN	NN	Number=Sing	_	_	_	_
16	strongly	strongly	ADV	RB	_	_	_	_	_
17	correlated	correlate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
18	with	with	ADP	IN	_	_	_	_	_
19	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
20	growth	growth	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
21	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
22	promoting	promote	VERB	VBG	VerbForm=Ger	_	_	_	_
23	effects	effect	NOUN	NNS	Number=Plur	_	_	_	_
24	of	of	ADP	IN	_	_	_	_	_
25	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
26	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
27	7	7	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
28	,	,	PUNCT	,	_	_	_	_	_
29	suggesting	suggest	VERB	VBG	VerbForm=Ger	_	_	_	_
30	that	that	SCONJ	IN	_	_	_	_	_
31	this	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
32	signal	signal	NOUN	NN	Number=Sing	_	_	_	_
33	transduction	transduction	NOUN	NN	Number=Sing	_	_	_	_
34	mechanism	mechanism	NOUN	NN	Number=Sing	_	_	_	_
35	may	may	AUX	MD	VerbForm=Fin	_	_	_	_
36	play	play	VERB	VB	VerbForm=Inf	_	_	_	_
37	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
38	key	key	ADJ	JJ	Degree=Pos	_	_	_	_
39	role	role	NOUN	NN	Number=Sing	_	_	_	_
40	in	in	ADP	IN	_	_	_	_	_
41	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
42	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
43	7	7	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
44	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
45	induced	induce	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
46	proliferation	proliferation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
47	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 2292
# text = Document 003003172 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	003003172	003003172	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 2293
# text = Tyrosine kinase and cAMP-dependent protein kinase activities in CD40-activated human B lymphocytes.
1	Tyrosine	Tyrosine	NOUN	NN	Number=Sing	_	_	_	_
2	kinase	kinase	NOUN	NN	Number=Sing	_	_	_	_
3	and	and	CCONJ	CC	_	_	_	_	_
4	cAMP	camp	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
5	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
6	dependent	dependent	ADJ	JJ	Degree=Pos	_	_	_	_
7	protein	protein	NOUN	NN	Number=Sing	_	_	_	_
8	kinase	kinase	NOUN	NN	Number=Sing	_	_	_	_
9	activities	activity	NOUN	NNS	Number=Plur	_	_	_	_
10	in	in	ADP	IN	_	_	_	_	_
11	CD40	CD40	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
12	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
13	activated	activate	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
14	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
15	B	b	NOUN	NN	Number=Sing	_	_	_	_
16	lymphocytes	lymphocyte	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
17	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 2294
# text = In vitro, human B lymphocytes undergo long-term proliferation when activated through CD40, a protein expressed on their cell surface.
1	In	in	ADP	IN	_	_	_	_	_
2	vitro	vitro	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
3	,	,	PUNCT	,	_	_	_	_	_
4	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
5	B	b	NOUN	NN	Number=Sing	_	_	_	_
6	lymphocytes	lymphocyte	NOUN	NNS	Number=Plur	_	_	_	_
7	undergo	undergo	ADV	RB	_	_	_	_	_
8	long	long	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
9	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
10	term	term	NOUN	NN	Number=Sing	_	_	_	_
11	proliferation	proliferation	NOUN	NN	Number=Sing	_	_	_	_
12	when	when	ADV	WRB	PronType=Int	_	_	_	_
13	activated	activate	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
14	through	through	ADP	IN	_	_	_	_	_
15	CD40	CD40	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
16	,	,	PUNCT	,	_	_	_	_	_
17	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
18	protein	protein	NOUN	NN	Number=Sing	_	_	_	_
19	expressed	express	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
20	on	on	ADP	IN	_	_	_	_	_
21	their	they	PRON	PRP$	Number=Plur|Person=3|Poss=Yes|PronType=Prs	_	_	_	_
22	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
23	surface	surface	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
24	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2295
# text = The nature of CD40-dependent signals in proliferating fresh human Epstein-Barr virus-negative B lymphocytes is currently unknown.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	nature	nature	NOUN	NN	Number=Sing	_	_	_	_
3	of	of	ADP	IN	_	_	_	_	_
4	CD40	CD40	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
5	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
6	dependent	dependent	ADJ	JJ	Degree=Pos	_	_	_	_
7	signals	signal	NOUN	NNS	Number=Plur	_	_	_	_
8	in	in	SCONJ	IN	_	_	_	_	_
9	proliferating	proliferate	VERB	VBG	VerbForm=Ger	_	_	_	_
10	fresh	fresh	ADV	RB	_	_	_	_	_
11	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
12	Epstein	Epstein	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
13	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
14	Barr	Barr	PROPN	NNP	Number=Sing	_	_	_	_
15	virus	virus	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
16	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
17	negative	negative	ADJ	JJ	Degree=Pos	_	_	_	_
18	B	b	NOUN	NN	Number=Sing	_	_	_	_
19	lymphocytes	lymphocyte	NOUN	NNS	Number=Plur	_	_	_	_
20	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
21	currently	currently	ADV	RB	_	_	_	_	_
22	unknown	unknown	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
23	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2296
# text = In this study, a CD40-dependent B cell culture system was used to examine the role of different signal transduction elements.
1	In	in	ADP	IN	_	_	_	_	_
2	this	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
3	study	study	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
4	,	,	PUNCT	,	_	_	_	_	_
5	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
6	CD40	CD40	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
7	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
8	dependent	dependent	ADJ	JJ	Degree=Pos	_	_	_	_
9	B	b	NOUN	NN	Number=Sing	_	_	_	_
10	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
11	culture	culture	NOUN	NN	Number=Sing	_	_	_	_
12	system	system	NOUN	NN	Number=Sing	_	_	_	_
13	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
14	used	use	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
15	to	to	PART	TO	_	_	_	_	_
16	examine	examine	VERB	VB	VerbForm=Inf	_	_	_	_
17	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
18	role	role	NOUN	NN	Number=Sing	_	_	_	_
19	of	of	ADP	IN	_	_	_	_	_
20	different	different	ADJ	JJ	Degree=Pos	_	_	_	_
21	signal	signal	NOUN	NN	Number=Sing	_	_	_	_
22	transduction	transduction	NOUN	NN	Number=Sing	_	_	_	_
23	elements	element	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
24	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2297
# text = Protein kinase C (PKC) depletion generated by a long-term phorbol 12 myristate 13-acetate treatment had weak effects on proliferation.
1	Protein	protein	NOUN	NN	Number=Sing	_	_	_	_
2	kinase	kinase	NOUN	NN	Number=Sing	_	_	_	_
3	C	C	PROPN	NNP	Number=Sing	_	_	_	_
4	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
5	PKC	PKC	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
6	)	)	PUNCT	-RRB-	_	_	_	_	_
7	depletion	depletion	NOUN	NN	Number=Sing	_	_	_	_
8	generated	generate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
9	by	by	ADP	IN	_	_	_	_	_
10	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
11	long	long	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
12	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
13	term	term	NOUN	NN	Number=Sing	_	_	_	_
14	phorbol	phorbol	NOUN	NN	Number=Sing	_	_	_	_
15	12	12	NUM	CD	NumType=Card	_	_	_	_
16	myristate	myristate	NOUN	NN	Number=Sing	_	_	_	_
17	13	13	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
18	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
19	acetate	acetate	NOUN	NN	Number=Sing	_	_	_	_
20	treatment	treatment	NOUN	NN	Number=Sing	_	_	_	_
21	had	have	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
22	weak	weak	ADJ	JJ	Degree=Pos	_	_	_	_
23	effects	effect	NOUN	NNS	Number=Plur	_	_	_	_
24	on	on	ADP	IN	_	_	_	_	_
25	proliferation	proliferation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
26	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2298
# text = Rather, tyrosine phosphorylation was shown to be directly involved in mediating CD40-dependent signals.
1	Rather	Rather	ADV	RB	_	_	_	_	SpaceAfter=No
2	,	,	PUNCT	,	_	_	_	_	_
3	tyrosine	tyrosine	ADJ	JJ	Degree=Pos	_	_	_	_
4	phosphorylation	phosphorylation	NOUN	NN	Number=Sing	_	_	_	_
5	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
6	shown	show	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
7	to	to	PART	TO	_	_	_	_	_
8	be	be	AUX	VB	VerbForm=Inf	_	_	_	_
9	directly	directly	ADV	RB	_	_	_	_	_
10	involved	involved	ADJ	JJ	Degree=Pos	_	_	_	_
11	in	in	SCONJ	IN	_	_	_	_	_
12	mediating	mediat	VERB	VBG	VerbForm=Ger	_	_	_	_
13	CD40	CD40	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
14	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
15	dependent	dependent	ADJ	JJ	Degree=Pos	_	_	_	_
16	signals	signal	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
17	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2299
# text = The use of the protein tyrosine kinase (PTK)-specific inhibitor herbimycin A dramatically decreased cellular proliferation without altering the activity of the human immunodeficiency virus-1 long terminal repeat (HIV-1 LTR), a promoter largely dependent on the binding of nuclear factor kappa B (NF- kappa B).
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	use	use	NOUN	NN	Number=Sing	_	_	_	_
3	of	of	ADP	IN	_	_	_	_	_
4	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
5	protein	protein	NOUN	NN	Number=Sing	_	_	_	_
6	tyrosine	tyrosine	NOUN	NN	Number=Sing	_	_	_	_
7	kinase	kinase	NOUN	NN	Number=Sing	_	_	_	_
8	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
9	PTK	PTK	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
10	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
11	-	-	PUNCT	:	_	_	_	_	SpaceAfter=No
12	specific	specific	ADJ	JJ	Degree=Pos	_	_	_	_
13	inhibitor	inhibitor	NOUN	NN	Number=Sing	_	_	_	_
14	herbimycin	herbimycin	NOUN	NN	Number=Sing	_	_	_	_
15	A	a	X	GW	_	_	_	_	_
16	dramatically	dramatically	ADV	RB	_	_	_	_	_
17	decreased	decrease	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
18	cellular	cellular	ADJ	JJ	Degree=Pos	_	_	_	_
19	proliferation	proliferation	NOUN	NN	Number=Sing	_	_	_	_
20	without	without	SCONJ	IN	_	_	_	_	_
21	altering	alter	VERB	VBG	VerbForm=Ger	_	_	_	_
22	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
23	activity	activity	NOUN	NN	Number=Sing	_	_	_	_
24	of	of	ADP	IN	_	_	_	_	_
25	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
26	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
27	immunodeficiency	immunodeficiency	NOUN	NN	Number=Sing	_	_	_	_
28	virus	virus	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
29	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
30	1	1	NUM	CD	NumType=Card	_	_	_	_
31	long	long	ADJ	JJ	Degree=Pos	_	_	_	_
32	terminal	terminal	NOUN	NN	Number=Sing	_	_	_	_
33	repeat	repeat	NOUN	NN	Number=Sing	_	_	_	_
34	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
35	HIV	Hiv	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
36	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
37	1	1	NUM	CD	NumType=Card	_	_	_	_
38	LTR	Ltr	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
39	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
40	,	,	PUNCT	,	_	_	_	_	_
41	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
42	promoter	promoter	NOUN	NN	Number=Sing	_	_	_	_
43	largely	largely	ADV	RB	_	_	_	_	_
44	dependent	dependent	ADJ	JJ	Degree=Pos	_	_	_	_
45	on	on	ADP	IN	_	_	_	_	_
46	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
47	binding	binding	NOUN	NN	Number=Sing	_	_	_	_
48	of	of	ADP	IN	_	_	_	_	_
49	nuclear	nuclear	ADJ	JJ	Degree=Pos	_	_	_	_
50	factor	factor	NOUN	NN	Number=Sing	_	_	_	_
51	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_
52	B	b	NOUN	NN	Number=Sing	_	_	_	_
53	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
54	NF	Nf	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
55	-	-	PUNCT	HYPH	_	_	_	_	_
56	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_
57	B	b	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
58	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
59	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2300
# text = In contrast, the cAMP-dependent protein kinase specific inhibitor H-89 totally inhibited HIV-1 LTR activity at a concentration as low as 100 nM without affecting cellular proliferation.
1	In	in	ADP	IN	_	_	_	_	_
2	contrast	contrast	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
3	,	,	PUNCT	,	_	_	_	_	_
4	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
5	cAMP	camp	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
6	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
7	dependent	dependent	ADJ	JJ	Degree=Pos	_	_	_	_
8	protein	protein	NOUN	NN	Number=Sing	_	_	_	_
9	kinase	kinase	NOUN	NN	Number=Sing	_	_	_	_
10	specific	specific	ADJ	JJ	Degree=Pos	_	_	_	_
11	inhibitor	inhibitor	NOUN	NN	Number=Sing	_	_	_	_
12	H	h	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
13	-	-	PUNCT	:	_	_	_	_	SpaceAfter=No
14	89	89	NUM	CD	NumType=Card	_	_	_	_
15	totally	totally	ADV	RB	_	_	_	_	_
16	inhibited	inhibit	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
17	HIV	HIV	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
18	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
19	1	1	NUM	CD	NumType=Card	_	_	_	_
20	LTR	Ltr	NOUN	NN	Number=Sing	_	_	_	_
21	activity	activity	NOUN	NN	Number=Sing	_	_	_	_
22	at	at	ADP	IN	_	_	_	_	_
23	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
24	concentration	concentration	NOUN	NN	Number=Sing	_	_	_	_
25	as	as	ADV	RB	_	_	_	_	_
26	low	low	ADJ	JJ	Degree=Pos	_	_	_	_
27	as	as	ADP	IN	_	_	_	_	_
28	100	100	NUM	CD	NumType=Card	_	_	_	_
29	nM	nm	NOUN	NN	Number=Sing	_	_	_	_
30	without	without	SCONJ	IN	_	_	_	_	_
31	affecting	affect	VERB	VBG	VerbForm=Ger	_	_	_	_
32	cellular	cellular	ADJ	JJ	Degree=Pos	_	_	_	_
33	proliferation	proliferation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
34	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2301
# text = Electrophoretic mobility shift assay (EMSA) and supershift assay using an NF-kappa B binding sequence from the kappa light chain as a probe, revealed that both p65 (RelA) and c-Rel were present in CD40-stimulated B cells.
1	Electrophoretic	Electrophoretic	ADJ	JJ	Degree=Pos	_	_	_	_
2	mobility	mobility	NOUN	NN	Number=Sing	_	_	_	_
3	shift	shift	NOUN	NN	Number=Sing	_	_	_	_
4	assay	assay	NOUN	NN	Number=Sing	_	_	_	_
5	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
6	EMSA	EMSA	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
7	)	)	PUNCT	-RRB-	_	_	_	_	_
8	and	and	CCONJ	CC	_	_	_	_	_
9	supershift	supershift	VERB	VB	Mood=Imp|VerbForm=Fin	_	_	_	_
10	assay	assay	NOUN	NN	Number=Sing	_	_	_	_
11	using	use	VERB	VBG	VerbForm=Ger	_	_	_	_
12	an	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
13	NF	Nf	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
14	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
15	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_
16	B	b	NOUN	NN	Number=Sing	_	_	_	_
17	binding	binde	VERB	VBG	VerbForm=Ger	_	_	_	_
18	sequence	sequence	NOUN	NN	Number=Sing	_	_	_	_
19	from	from	ADP	IN	_	_	_	_	_
20	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
21	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_
22	light	light	NOUN	NN	Number=Sing	_	_	_	_
23	chain	chain	NOUN	NN	Number=Sing	_	_	_	_
24	as	as	ADP	IN	_	_	_	_	_
25	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
26	probe	probe	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
27	,	,	PUNCT	,	_	_	_	_	_
28	revealed	reveal	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
29	that	that	SCONJ	IN	_	_	_	_	_
30	both	both	DET	DT	_	_	_	_	_
31	p65	p65	NOUN	NN	Number=Sing	_	_	_	_
32	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
33	RelA	RelA	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
34	)	)	PUNCT	-RRB-	_	_	_	_	_
35	and	and	CCONJ	CC	_	_	_	_	_
36	c	c	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
37	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
38	Rel	Rel	NOUN	NN	Number=Sing	_	_	_	_
39	were	be	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
40	present	presend	ADJ	JJ	Degree=Pos	_	_	_	_
41	in	in	ADP	IN	_	_	_	_	_
42	CD40	CD40	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
43	-	-	PUNCT	:	_	_	_	_	SpaceAfter=No
44	stimulated	stimulate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
45	B	b	ADJ	JJ	Degree=Pos	_	_	_	_
46	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
47	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2302
# text = While PKC depletion did not alter the NF-kappa B level, treatment of B lymphocytes with H-89 or herbimycin A provoked a decrease in the NF-kappa B level.
1	While	while	SCONJ	IN	_	_	_	_	_
2	PKC	PKC	PROPN	NNP	Number=Sing	_	_	_	_
3	depletion	depletion	NOUN	NN	Number=Sing	_	_	_	_
4	did	do	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
5	not	not	PART	RB	_	_	_	_	_
6	alter	alter	VERB	VB	VerbForm=Inf	_	_	_	_
7	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
8	NF	Nf	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
9	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
10	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_
11	B	b	NOUN	NN	Number=Sing	_	_	_	_
12	level	level	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
13	,	,	PUNCT	,	_	_	_	_	_
14	treatment	treatment	NOUN	NN	Number=Sing	_	_	_	_
15	of	of	ADP	IN	_	_	_	_	_
16	B	b	ADJ	JJ	Degree=Pos	_	_	_	_
17	lymphocytes	lymphocyte	NOUN	NNS	Number=Plur	_	_	_	_
18	with	with	ADP	IN	_	_	_	_	_
19	H	H	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
20	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
21	89	89	NUM	CD	NumType=Card	_	_	_	_
22	or	or	CCONJ	CC	_	_	_	_	_
23	herbimycin	herbimycin	NOUN	NN	Number=Sing	_	_	_	_
24	A	and	NOUN	NN	Number=Sing	_	_	_	_
25	provoked	provoke	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
26	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
27	decrease	decrease	NOUN	NN	Number=Sing	_	_	_	_
28	in	in	ADP	IN	_	_	_	_	_
29	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
30	NF	NF	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
31	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
32	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_
33	B	b	NOUN	NN	Number=Sing	_	_	_	_
34	level	level	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
35	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2303
# text = These observations establish the importance of different signal transducing pathways leading to CD40 activation of B lymphocytes.
1	These	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
2	observations	observation	NOUN	NNS	Number=Plur	_	_	_	_
3	establish	establish	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
4	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
5	importance	importance	NOUN	NN	Number=Sing	_	_	_	_
6	of	of	ADP	IN	_	_	_	_	_
7	different	different	ADJ	JJ	Degree=Pos	_	_	_	_
8	signal	signal	NOUN	NN	Number=Sing	_	_	_	_
9	transducing	transduce	VERB	VBG	VerbForm=Ger	_	_	_	_
10	pathways	pathway	NOUN	NNS	Number=Plur	_	_	_	_
11	leading	lead	VERB	VBG	VerbForm=Ger	_	_	_	_
12	to	to	ADP	IN	_	_	_	_	_
13	CD40	CD40	PROPN	NNP	Number=Sing	_	_	_	_
14	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
15	of	of	ADP	IN	_	_	_	_	_
16	B	b	ADJ	JJ	Degree=Pos	_	_	_	_
17	lymphocytes	lymphocyte	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
18	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 2304
# text = Document 003003176 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	003003176	003003176	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 2305
# text = Effects of 1 alpha, 25-dihydroxyvitamin D3 on the human chronic myelogenous leukemia cell line RWLeu-4.
1	Effects	Effects	PROPN	NNPS	Number=Plur	_	_	_	_
2	of	of	ADP	IN	_	_	_	_	_
3	1	1	NUM	CD	NumType=Card	_	_	_	_
4	alpha	alpha	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
5	,	,	PUNCT	,	_	_	_	_	_
6	25	25	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
7	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
8	dihydroxyvitamin	dihydroxyvitamin	NOUN	NN	Number=Sing	_	_	_	_
9	D3	D3	NOUN	NN	Number=Sing	_	_	_	_
10	on	on	ADP	IN	_	_	_	_	_
11	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
12	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
13	chronic	chronic	ADJ	JJ	Degree=Pos	_	_	_	_
14	myelogenous	myelogenous	ADJ	JJ	Degree=Pos	_	_	_	_
15	leukemia	leukemia	NOUN	NN	Number=Sing	_	_	_	_
16	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
17	line	line	NOUN	NN	Number=Sing	_	_	_	_
18	RWLeu	RWLeu	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
19	-	-	PUNCT	:	_	_	_	_	SpaceAfter=No
20	4	4	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
21	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 2306
# text = The effects of 1 alpha, 25-dihydroxyvitamin D3 (VD3) on proliferation, differentiation, and macromolecular synthesis in the new Philadelphia chromosome-positive chronic myelogenous leukemia cell line, RWLeu-4, were investigated.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	effects	effect	NOUN	NNS	Number=Plur	_	_	_	_
3	of	of	ADP	IN	_	_	_	_	_
4	1	1	NUM	CD	NumType=Card	_	_	_	_
5	alpha	alpha	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
6	,	,	PUNCT	,	_	_	_	_	_
7	25	25	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
8	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
9	dihydroxyvitamin	dihydroxyvitamin	NOUN	NN	Number=Sing	_	_	_	_
10	D3	D3	NOUN	NN	Number=Sing	_	_	_	_
11	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
12	VD3	VD3	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
13	)	)	PUNCT	-RRB-	_	_	_	_	_
14	on	on	ADP	IN	_	_	_	_	_
15	proliferation	proliferation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
16	,	,	PUNCT	,	_	_	_	_	_
17	differentiation	differentiation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
18	,	,	PUNCT	,	_	_	_	_	_
19	and	and	CCONJ	CC	_	_	_	_	_
20	macromolecular	macromolecular	ADJ	JJ	Degree=Pos	_	_	_	_
21	synthesis	synthesis	NOUN	NN	Number=Sing	_	_	_	_
22	in	in	ADP	IN	_	_	_	_	_
23	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
24	new	new	ADJ	JJ	Degree=Pos	_	_	_	_
25	Philadelphia	Philadelphia	PROPN	NNP	Number=Sing	_	_	_	_
26	chromosome	chromosome	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
27	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
28	positive	positive	ADJ	JJ	Degree=Pos	_	_	_	_
29	chronic	chronic	ADJ	JJ	Degree=Pos	_	_	_	_
30	myelogenous	myelogenous	ADJ	JJ	Degree=Pos	_	_	_	_
31	leukemia	leukemia	NOUN	NN	Number=Sing	_	_	_	_
32	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
33	line	line	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
34	,	,	PUNCT	,	_	_	_	_	_
35	RWLeu	RWLeu	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
36	-	-	SYM	SYM	_	_	_	_	SpaceAfter=No
37	4	4	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
38	,	,	PUNCT	,	_	_	_	_	_
39	were	be	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
40	investigated	investigate	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	SpaceAfter=No
41	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2307
# text = Binding of [3H]VD3 was saturable, with approximately 2000-3000 sites/cell, and half-maximal binding occurring at 0.21-0.33 nM.
1	Binding	binding	NOUN	NN	Number=Sing	_	_	_	_
2	of	of	ADP	IN	_	_	_	_	_
3	[	[	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
4	3H]	3h]	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
5	VD3	VD3	NOUN	NN	Number=Sing	_	_	_	_
6	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
7	saturable	saturable	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
8	,	,	PUNCT	,	_	_	_	_	_
9	with	with	ADP	IN	_	_	_	_	_
10	approximately	approximately	ADV	RB	_	_	_	_	_
11	2000	2000	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
12	-	-	SYM	SYM	_	_	_	_	SpaceAfter=No
13	3000	3000	NUM	CD	NumType=Card	_	_	_	_
14	sites	site	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
15	/	/	PUNCT	,	_	_	_	_	SpaceAfter=No
16	cell	cell	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
17	,	,	PUNCT	,	_	_	_	_	_
18	and	and	CCONJ	CC	_	_	_	_	_
19	half	half	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
20	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
21	maximal	maximal	ADJ	JJ	Degree=Pos	_	_	_	_
22	binding	binding	NOUN	NN	Number=Sing	_	_	_	_
23	occurring	occurre	VERB	VBG	VerbForm=Ger	_	_	_	_
24	at	at	ADP	IN	_	_	_	_	_
25	0.21	0.21	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
26	-	-	SYM	SYM	_	_	_	_	SpaceAfter=No
27	0.33	0.33	NUM	CD	NumType=Card	_	_	_	_
28	nM	nm	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
29	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2308
# text = Treatment of RWLeu-4 cells with VD3 induced 24R-hydroxylase activity, a marker of vitamin D3 responsiveness in many tissues.
1	Treatment	treatment	NOUN	NN	Number=Sing	_	_	_	_
2	of	of	ADP	IN	_	_	_	_	_
3	RWLeu	RWLeu	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
4	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
5	4	4	NUM	CD	NumType=Card	_	_	_	_
6	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
7	with	with	ADP	IN	_	_	_	_	_
8	VD3	VD3	NUM	CD	NumType=Card	_	_	_	_
9	induced	induce	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
10	24R	24r	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
11	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
12	hydroxylase	hydroxylase	NOUN	NN	Number=Sing	_	_	_	_
13	activity	activity	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
14	,	,	PUNCT	,	_	_	_	_	_
15	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
16	marker	marker	NOUN	NN	Number=Sing	_	_	_	_
17	of	of	ADP	IN	_	_	_	_	_
18	vitamin	vitamin	ADJ	JJ	Degree=Pos	_	_	_	_
19	D3	D3	NOUN	NN	Number=Sing	_	_	_	_
20	responsiveness	responsiveness	NOUN	NN	Number=Sing	_	_	_	_
21	in	in	ADP	IN	_	_	_	_	_
22	many	many	ADJ	JJ	Degree=Pos	_	_	_	_
23	tissues	tissue	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
24	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2309
# text = Exposure of RWLeu-4 cells to VD3 also inhibited proliferation and DNA synthesis with a 50% effective dose of 3.5-10 nM within 72 h; in addition, protein and RNA synthesis were inhibited by VD3 treatment.
1	Exposure	exposure	NOUN	NN	Number=Sing	_	_	_	_
2	of	of	ADP	IN	_	_	_	_	_
3	RWLeu	RWLeu	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
4	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
5	4	4	NUM	CD	NumType=Card	_	_	_	_
6	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
7	to	to	ADP	IN	_	_	_	_	_
8	VD3	VD3	NUM	CD	NumType=Card	_	_	_	_
9	also	also	ADV	RB	_	_	_	_	_
10	inhibited	inhibit	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
11	proliferation	proliferation	NOUN	NN	Number=Sing	_	_	_	_
12	and	and	CCONJ	CC	_	_	_	_	_
13	DNA	dna	NOUN	NN	Number=Sing	_	_	_	_
14	synthesis	synthesis	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
15	with	with	ADP	IN	_	_	_	_	_
16	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
17	50	50	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
18	%	%	SYM	NN	Number=Sing	_	_	_	_
19	effective	effective	ADJ	JJ	Degree=Pos	_	_	_	_
20	dose	dose	NOUN	NN	Number=Sing	_	_	_	_
21	of	of	ADP	IN	_	_	_	_	_
22	3.5	3.5	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
23	-	-	SYM	SYM	_	_	_	_	SpaceAfter=No
24	10	10	NUM	CD	NumType=Card	_	_	_	_
25	nM	nm	NUM	CD	NumType=Card	_	_	_	_
26	within	within	ADP	IN	_	_	_	_	_
27	72	72	NUM	CD	NumType=Card	_	_	_	_
28	h	h	INTJ	UH	_	_	_	_	SpaceAfter=No
29	;	;	PUNCT	,	_	_	_	_	_
30	in	in	ADP	IN	_	_	_	_	_
31	addition	addition	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
32	,	,	PUNCT	,	_	_	_	_	_
33	protein	protein	NOUN	NN	Number=Sing	_	_	_	_
34	and	and	CCONJ	CC	_	_	_	_	_
35	RNA	RNA	PROPN	NNP	Number=Sing	_	_	_	_
36	synthesis	synthesis	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
37	were	be	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
38	inhibited	inhibit	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
39	by	by	ADP	IN	_	_	_	_	_
40	VD3	VD3	NUM	CD	NumType=Card	_	_	_	_
41	treatment	treatment	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
42	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2310
# text = Exposure of RWLeu-4 cells to 5 nM VD3 for 72 h caused 50% of the cells to differentiate into macrophage/monocyte type cells as judged by nitroblue tetrazolium staining and adherence to plastic.
1	Exposure	exposure	NOUN	NN	Number=Sing	_	_	_	_
2	of	of	ADP	IN	_	_	_	_	_
3	RWLeu	RWLeu	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
4	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
5	4	4	NUM	CD	NumType=Card	_	_	_	_
6	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
7	to	to	ADP	IN	_	_	_	_	_
8	5	5	NUM	CD	NumType=Card	_	_	_	_
9	nM	nm	NUM	CD	NumType=Card	_	_	_	_
10	VD3	VD3	NUM	CD	NumType=Card	_	_	_	_
11	for	for	ADP	IN	_	_	_	_	_
12	72	72	NUM	CD	NumType=Card	_	_	_	_
13	h	h	NOUN	NN	Number=Sing	_	_	_	_
14	caused	cause	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
15	50	50	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
16	%	%	SYM	NN	Number=Sing	_	_	_	_
17	of	of	ADP	IN	_	_	_	_	_
18	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
19	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
20	to	to	PART	TO	_	_	_	_	_
21	differentiate	differentiate	VERB	VB	VerbForm=Inf	_	_	_	_
22	into	into	ADP	IN	_	_	_	_	_
23	macrophage	macrophage	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
24	/	/	PUNCT	,	_	_	_	_	SpaceAfter=No
25	monocyte	monocyte	NOUN	NN	Number=Sing	_	_	_	_
26	type	type	NOUN	NN	Number=Sing	_	_	_	_
27	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
28	as	as	SCONJ	IN	_	_	_	_	_
29	judged	judge	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
30	by	by	ADP	IN	_	_	_	_	_
31	nitroblue	nitroblue	NOUN	NN	Number=Sing	_	_	_	_
32	tetrazolium	tetrazolium	NOUN	NN	Number=Sing	_	_	_	_
33	staining	staining	NOUN	NN	Number=Sing	_	_	_	_
34	and	and	CCONJ	CC	_	_	_	_	_
35	adherence	adherence	NOUN	NN	Number=Sing	_	_	_	_
36	to	to	ADP	IN	_	_	_	_	_
37	plastic	plastic	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
38	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2311
# text = Progressive expression of cell surface maturation-specific antigens of the monocyte/macrophage lineage was induced by treatment of RWLeu-4 cells with VD3 for 24 to 72 h at doses that inhibited cellular proliferation.
1	Progressive	progressive	ADJ	JJ	Degree=Pos	_	_	_	_
2	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
3	of	of	ADP	IN	_	_	_	_	_
4	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
5	surface	surface	NOUN	NN	Number=Sing	_	_	_	_
6	maturation	maturation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
7	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
8	specific	specific	ADJ	JJ	Degree=Pos	_	_	_	_
9	antigens	antigen	NOUN	NNS	Number=Plur	_	_	_	_
10	of	of	ADP	IN	_	_	_	_	_
11	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
12	monocyte	monocyte	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
13	/	/	PUNCT	,	_	_	_	_	SpaceAfter=No
14	macrophage	macrophage	NOUN	NN	Number=Sing	_	_	_	_
15	lineage	lineage	NOUN	NN	Number=Sing	_	_	_	_
16	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
17	induced	induce	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
18	by	by	ADP	IN	_	_	_	_	_
19	treatment	treatment	NOUN	NN	Number=Sing	_	_	_	_
20	of	of	ADP	IN	_	_	_	_	_
21	RWLeu	RWLeu	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
22	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
23	4	4	NUM	CD	NumType=Card	_	_	_	_
24	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
25	with	with	ADP	IN	_	_	_	_	_
26	VD3	VD3	NUM	CD	NumType=Card	_	_	_	_
27	for	for	ADP	IN	_	_	_	_	_
28	24	24	NUM	CD	NumType=Card	_	_	_	_
29	to	to	ADP	IN	_	_	_	_	_
30	72	72	NUM	CD	NumType=Card	_	_	_	_
31	h	h	NOUN	NN	Number=Sing	_	_	_	_
32	at	at	ADP	IN	_	_	_	_	_
33	doses	dos	NOUN	NNS	Number=Plur	_	_	_	_
34	that	that	PRON	WDT	PronType=Rel	_	_	_	_
35	inhibited	inhibit	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
36	cellular	cellular	ADJ	JJ	Degree=Pos	_	_	_	_
37	proliferation	proliferation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
38	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2312
# text = c-myc RNA, which is constitutively expressed in RWLeu-4 cells, increased after 0.5 h of treatment with 50 nM VD3 and then rapidly decreased to barely detectable levels after 4 h of treatment.
1	c-myc	c-myc	NOUN	NN	Number=Sing	_	_	_	_
2	RNA	RNa	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
3	,	,	PUNCT	,	_	_	_	_	_
4	which	which	PRON	WDT	PronType=Rel	_	_	_	_
5	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
6	constitutively	constitutively	ADV	RB	_	_	_	_	_
7	expressed	express	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
8	in	in	ADP	IN	_	_	_	_	_
9	RWLeu	RWLeu	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
10	-4	-4	NUM	CD	NumType=Card	_	_	_	_
11	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
12	,	,	PUNCT	,	_	_	_	_	_
13	increased	increase	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
14	after	after	ADP	IN	_	_	_	_	_
15	0.5	0.5	NUM	CD	NumType=Card	_	_	_	_
16	h	h	NOUN	NN	Number=Sing	_	_	_	_
17	of	of	ADP	IN	_	_	_	_	_
18	treatment	treatment	NOUN	NN	Number=Sing	_	_	_	_
19	with	with	ADP	IN	_	_	_	_	_
20	50	50	NUM	CD	NumType=Card	_	_	_	_
21	nM	nm	NOUN	NN	Number=Sing	_	_	_	_
22	VD3	VD3	NOUN	NN	Number=Sing	_	_	_	_
23	and	and	CCONJ	CC	_	_	_	_	_
24	then	then	ADV	RB	PronType=Dem	_	_	_	_
25	rapidly	rapidly	ADV	RB	_	_	_	_	_
26	decreased	decreased	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
27	to	to	ADP	IN	_	_	_	_	_
28	barely	barely	ADV	RB	_	_	_	_	_
29	detectable	detectable	ADJ	JJ	Degree=Pos	_	_	_	_
30	levels	level	NOUN	NNS	Number=Plur	_	_	_	_
31	after	after	ADP	IN	_	_	_	_	_
32	4	4	NUM	CD	NumType=Card	_	_	_	_
33	h	h	NOUN	NN	Number=Sing	_	_	_	_
34	of	of	ADP	IN	_	_	_	_	_
35	treatment	treatment	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
36	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2313
# text = Finally, the in vitro tyrosine kinase activity associated with the p210bcr-abl oncogene product was decreased approximately 50% by VD3 treatment.
1	Finally	finally	ADV	RB	_	_	_	_	SpaceAfter=No
2	,	,	PUNCT	,	_	_	_	_	_
3	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
4	in	in	ADP	IN	_	_	_	_	_
5	vitro	vitro	ADJ	JJ	Degree=Pos	_	_	_	_
6	tyrosine	tyrosine	NOUN	NN	Number=Sing	_	_	_	_
7	kinase	kinase	NOUN	NN	Number=Sing	_	_	_	_
8	activity	activity	NOUN	NN	Number=Sing	_	_	_	_
9	associated	associate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
10	with	with	ADP	IN	_	_	_	_	_
11	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
12	p210	p210	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
13	bcr-abl	bcr-abl	NOUN	NN	Number=Sing	_	_	_	_
14	oncogene	oncogene	NOUN	NN	Number=Sing	_	_	_	_
15	product	product	NOUN	NN	Number=Sing	_	_	_	_
16	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
17	decreased	decrease	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
18	approximately	approximately	ADV	RB	_	_	_	_	_
19	50	50	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
20	%	%	SYM	NN	Number=Sing	_	_	_	_
21	by	by	ADP	IN	_	_	_	_	_
22	VD3	VD3	NUM	CD	NumType=Card	_	_	_	_
23	treatment	treatment	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
24	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2314
# text = Because of the presence of a functional receptor-effector system for VD3 and multiple biological responses to the hormone, these cells provide a unique model system with which to probe the specific effects of VD3 on cell growth and differentiation in chronic myelogenous leukemia.
1	Because	because	ADP	IN	_	_	_	_	_
2	of	of	ADP	IN	_	_	_	_	_
3	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
4	presence	presence	NOUN	NN	Number=Sing	_	_	_	_
5	of	of	ADP	IN	_	_	_	_	_
6	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
7	functional	functional	ADJ	JJ	Degree=Pos	_	_	_	_
8	receptor	receptor	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
9	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
10	effector	effector	NOUN	NN	Number=Sing	_	_	_	_
11	system	system	NOUN	NN	Number=Sing	_	_	_	_
12	for	for	ADP	IN	_	_	_	_	_
13	VD3	VD3	NUM	CD	NumType=Card	_	_	_	_
14	and	and	CCONJ	CC	_	_	_	_	_
15	multiple	multiple	ADJ	JJ	Degree=Pos	_	_	_	_
16	biological	biological	ADJ	JJ	Degree=Pos	_	_	_	_
17	responses	response	NOUN	NNS	Number=Plur	_	_	_	_
18	to	to	ADP	IN	_	_	_	_	_
19	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
20	hormone	hormone	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
21	,	,	PUNCT	,	_	_	_	_	_
22	these	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
23	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
24	provide	provide	VERB	VB	VerbForm=Inf	_	_	_	_
25	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
26	unique	unique	ADJ	JJ	Degree=Pos	_	_	_	_
27	model	model	NOUN	NN	Number=Sing	_	_	_	_
28	system	system	NOUN	NN	Number=Sing	_	_	_	_
29	with	with	ADP	IN	_	_	_	_	_
30	which	which	PRON	WDT	PronType=Rel	_	_	_	_
31	to	to	PART	TO	_	_	_	_	_
32	probe	probe	VERB	VB	VerbForm=Inf	_	_	_	_
33	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
34	specific	specific	ADJ	JJ	Degree=Pos	_	_	_	_
35	effects	effect	NOUN	NNS	Number=Plur	_	_	_	_
36	of	of	ADP	IN	_	_	_	_	_
37	VD3	VD3	NOUN	NN	Number=Sing	_	_	_	_
38	on	on	ADP	IN	_	_	_	_	_
39	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
40	growth	growth	NOUN	NN	Number=Sing	_	_	_	_
41	and	and	CCONJ	CC	_	_	_	_	_
42	differentiation	differentiation	NOUN	NN	Number=Sing	_	_	_	_
43	in	in	ADP	IN	_	_	_	_	_
44	chronic	chronic	ADJ	JJ	Degree=Pos	_	_	_	_
45	myelogenous	myelogenous	ADJ	JJ	Degree=Pos	_	_	_	_
46	leukemia	leukemia	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
47	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 2315
# text = Document 003003178 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	003003178	003003178	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 2316
# text = Cell cycle-dependent initiation and lineage-dependent abrogation of GATA-1 expression in pure differentiating hematopoietic progenitors.
1	Cell	cell	NOUN	NN	Number=Sing	_	_	_	_
2	cycle	cycle	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
3	-dependent	-dependent	ADJ	JJ	Degree=Pos	_	_	_	_
4	initiation	initiation	NOUN	NN	Number=Sing	_	_	_	_
5	and	and	CCONJ	CC	_	_	_	_	_
6	lineage	lineage	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
7	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
8	dependent	dependent	ADJ	JJ	Degree=Pos	_	_	_	_
9	abrogation	abrogation	NOUN	NN	Number=Sing	_	_	_	_
10	of	of	ADP	IN	_	_	_	_	_
11	GATA	GATA	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
12	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
13	1	1	NUM	CD	NumType=Card	_	_	_	_
14	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
15	in	in	ADP	IN	_	_	_	_	_
16	pure	pure	ADJ	JJ	Degree=Pos	_	_	_	_
17	differentiating	differentiating	VERB	VBG	VerbForm=Ger	_	_	_	_
18	hematopoietic	hematopoietic	ADJ	JJ	Degree=Pos	_	_	_	_
19	progenitors	progenitor	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
20	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 2317
# text = The programmed activation/repression of transcription factors in early hematopoietic differentiation has not yet been explored.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	programmed	program	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
3	activation	activation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
4	/	/	PUNCT	,	_	_	_	_	SpaceAfter=No
5	repression	repression	NOUN	NN	Number=Sing	_	_	_	_
6	of	of	ADP	IN	_	_	_	_	_
7	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
8	factors	factor	NOUN	NNS	Number=Plur	_	_	_	_
9	in	in	ADP	IN	_	_	_	_	_
10	early	early	ADJ	JJ	Degree=Pos	_	_	_	_
11	hematopoietic	hematopoietic	ADJ	JJ	Degree=Pos	_	_	_	_
12	differentiation	differentiation	NOUN	NN	Number=Sing	_	_	_	_
13	has	have	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
14	not	not	PART	RB	_	_	_	_	_
15	yet	yet	ADV	RB	_	_	_	_	_
16	been	be	AUX	VBN	Tense=Past|VerbForm=Part	_	_	_	_
17	explored	explore	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	SpaceAfter=No
18	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2318
# text = The DNA-binding protein GATA-1 is required for normal erythroid development and regulates erythroid-expressed genes in maturing erythroblasts.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	DNA	dna	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
3	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
4	binding	binding	VERB	VBG	VerbForm=Ger	_	_	_	_
5	protein	protein	NOUN	NN	Number=Sing	_	_	_	_
6	GATA	GATa	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
7	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
8	1	1	NUM	CD	NumType=Card	_	_	_	_
9	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
10	required	require	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
11	for	for	ADP	IN	_	_	_	_	_
12	normal	normal	ADJ	JJ	Degree=Pos	_	_	_	_
13	erythroid	erythroid	ADJ	JJ	Degree=Pos	_	_	_	_
14	development	development	NOUN	NN	Number=Sing	_	_	_	_
15	and	and	CCONJ	CC	_	_	_	_	_
16	regulates	regulate	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
17	erythroid	erythroid	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
18	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
19	expressed	express	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
20	genes	gene	NOUN	NNS	Number=Plur	_	_	_	_
21	in	in	ADP	IN	_	_	_	_	_
22	maturing	mature	ADJ	JJ	Degree=Pos	_	_	_	_
23	erythroblasts	erythroblast	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
24	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2319
# text = We analyzed GATA-1 expression in early human adult hematopoiesis by using an in vitro system in which "pure" early hematopoietic progenitors are induced to gradual and synchronized differentiation selectively along the erythroid or granulocyte-macrophage pathway by differential treatment with hematopoietic growth factors.
1	We	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
2	analyzed	analyze	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
3	GATA	GATA	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
4	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
5	1	1	NUM	CD	NumType=Card	_	_	_	_
6	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
7	in	in	ADP	IN	_	_	_	_	_
8	early	early	ADJ	JJ	Degree=Pos	_	_	_	_
9	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
10	adult	adult	NOUN	NN	Number=Sing	_	_	_	_
11	hematopoiesis	hematopoiesis	NOUN	NN	Number=Sing	_	_	_	_
12	by	by	SCONJ	IN	_	_	_	_	_
13	using	use	VERB	VBG	VerbForm=Ger	_	_	_	_
14	an	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
15	in	in	ADP	IN	_	_	_	_	_
16	vitro	vitro	ADJ	JJ	Degree=Pos	_	_	_	_
17	system	system	NOUN	NN	Number=Sing	_	_	_	_
18	in	in	ADP	IN	_	_	_	_	_
19	which	which	PRON	WDT	PronType=Rel	_	_	_	_
20	"	"	PUNCT	``	_	_	_	_	SpaceAfter=No
21	pure	pure	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
22	"	"	PUNCT	''	_	_	_	_	_
23	early	early	ADJ	JJ	Degree=Pos	_	_	_	_
24	hematopoietic	hematopoietic	ADJ	JJ	Degree=Pos	_	_	_	_
25	progenitors	progenitor	NOUN	NNS	Number=Plur	_	_	_	_
26	are	be	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
27	induced	induce	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
28	to	to	PART	TO	_	_	_	_	_
29	gradual	gradual	VERB	VB	VerbForm=Inf	_	_	_	_
30	and	and	CCONJ	CC	_	_	_	_	_
31	synchronized	synchronize	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
32	differentiation	differentiation	NOUN	NN	Number=Sing	_	_	_	_
33	selectively	selectively	ADV	RB	_	_	_	_	_
34	along	along	ADP	IN	_	_	_	_	_
35	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
36	erythroid	erythroid	NOUN	NN	Number=Sing	_	_	_	_
37	or	or	CCONJ	CC	_	_	_	_	_
38	granulocyte	granulocyte	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
39	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
40	macrophage	macrophage	NOUN	NN	Number=Sing	_	_	_	_
41	pathway	pathway	NOUN	NN	Number=Sing	_	_	_	_
42	by	by	ADP	IN	_	_	_	_	_
43	differential	differential	ADJ	JJ	Degree=Pos	_	_	_	_
44	treatment	treatment	NOUN	NN	Number=Sing	_	_	_	_
45	with	with	ADP	IN	_	_	_	_	_
46	hematopoietic	hematopoietic	ADJ	JJ	Degree=Pos	_	_	_	_
47	growth	growth	NOUN	NN	Number=Sing	_	_	_	_
48	factors	factor	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
49	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2320
# text = The GATA-1 gene, though virtually silent in quiescent progenitors, is activated after entrance into the cell cycle upon stimulation with hematopoietic growth factors.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	GATA	GATa	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
3	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
4	1	1	NUM	CD	NumType=Card	_	_	_	_
5	gene	gene	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
6	,	,	PUNCT	,	_	_	_	_	_
7	though	though	SCONJ	IN	_	_	_	_	_
8	virtually	virtually	ADV	RB	_	_	_	_	_
9	silent	silent	ADJ	JJ	Degree=Pos	_	_	_	_
10	in	in	ADP	IN	_	_	_	_	_
11	quiescent	quiescent	ADJ	JJ	Degree=Pos	_	_	_	_
12	progenitors	progenitor	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
13	,	,	PUNCT	,	_	_	_	_	_
14	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
15	activated	activate	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
16	after	after	ADP	IN	_	_	_	_	_
17	entrance	entrance	NOUN	NN	Number=Sing	_	_	_	_
18	into	into	ADP	IN	_	_	_	_	_
19	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
20	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
21	cycle	cycle	NOUN	NN	Number=Sing	_	_	_	_
22	upon	upon	ADP	IN	_	_	_	_	_
23	stimulation	stimulation	NOUN	NN	Number=Sing	_	_	_	_
24	with	with	ADP	IN	_	_	_	_	_
25	hematopoietic	hematopoietic	ADJ	JJ	Degree=Pos	_	_	_	_
26	growth	growth	NOUN	NN	Number=Sing	_	_	_	_
27	factors	factor	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
28	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2321
# text = Subsequently, increasing expression along the erythroid pathway contrasts with an abrupt downregulation in the granulocyte-macrophage lineage.
1	Subsequently	subsequently	ADV	RB	_	_	_	_	SpaceAfter=No
2	,	,	PUNCT	,	_	_	_	_	_
3	increasing	increase	VERB	VBG	VerbForm=Ger	_	_	_	_
4	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
5	along	along	ADP	IN	_	_	_	_	_
6	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
7	erythroid	erythroid	ADJ	JJ	Degree=Pos	_	_	_	_
8	pathway	pathway	NOUN	NN	Number=Sing	_	_	_	_
9	contrasts	contrast	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
10	with	with	ADP	IN	_	_	_	_	_
11	an	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
12	abrupt	abrupt	ADJ	JJ	Degree=Pos	_	_	_	_
13	downregulation	downregulation	NOUN	NN	Number=Sing	_	_	_	_
14	in	in	ADP	IN	_	_	_	_	_
15	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
16	granulocyte	granulocyte	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
17	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
18	macrophage	macrophage	NOUN	NN	Number=Sing	_	_	_	_
19	lineage	lineage	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
20	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2322
# text = These results suggest a microenvironment-directed, two-step model for GATA-1 expression in differentiating hematopoietic progenitors that involves (i) cycle-dependent initiation and (ii) lineage-dependent maintenance or suppression.
1	These	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
2	results	result	NOUN	NNS	Number=Plur	_	_	_	_
3	suggest	suggest	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
4	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
5	microenvironment	microenvironment	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
6	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
7	directed	direct	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	SpaceAfter=No
8	,	,	PUNCT	,	_	_	_	_	_
9	two	two	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
10	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
11	step	step	NOUN	NN	Number=Sing	_	_	_	_
12	model	model	NOUN	NN	Number=Sing	_	_	_	_
13	for	for	ADP	IN	_	_	_	_	_
14	GATA	GATA	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
15	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
16	1	1	NUM	CD	NumType=Card	_	_	_	_
17	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
18	in	in	SCONJ	IN	_	_	_	_	_
19	differentiating	differentiat	VERB	VBG	VerbForm=Ger	_	_	_	_
20	hematopoietic	hematopoietic	ADJ	JJ	Degree=Pos	_	_	_	_
21	progenitors	progenitor	NOUN	NNS	Number=Plur	_	_	_	_
22	that	that	PRON	WDT	PronType=Rel	_	_	_	_
23	involves	involve	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
24	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
25	i	i	PRON	PRP	Case=Nom|Number=Sing|Person=1|PronType=Prs	_	_	_	SpaceAfter=No
26	)	)	PUNCT	-RRB-	_	_	_	_	_
27	cycle	cycle	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
28	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
29	dependent	dependent	ADJ	JJ	Degree=Pos	_	_	_	_
30	initiation	initiation	NOUN	NN	Number=Sing	_	_	_	_
31	and	and	CCONJ	CC	_	_	_	_	_
32	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
33	ii	ii	X	LS	_	_	_	_	SpaceAfter=No
34	)	)	PUNCT	-RRB-	_	_	_	_	_
35	lineage	lineage	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
36	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
37	dependent	dependent	ADJ	JJ	Degree=Pos	_	_	_	_
38	maintenance	maintenance	NOUN	NN	Number=Sing	_	_	_	_
39	or	or	CCONJ	CC	_	_	_	_	_
40	suppression	suppression	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
41	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2323
# text = Hypothetically, on/off switches of lineage-restricted transactivators may underlie the binary fate decisions of hematopoietic progenitors.
1	Hypothetically	Hypothetically	ADV	RB	_	_	_	_	SpaceAfter=No
2	,	,	PUNCT	,	_	_	_	_	_
3	on	on	ADP	IN	_	_	_	_	SpaceAfter=No
4	/	/	PUNCT	,	_	_	_	_	SpaceAfter=No
5	off	off	ADP	IN	_	_	_	_	_
6	switches	switche	NOUN	NNS	Number=Plur	_	_	_	_
7	of	of	ADP	IN	_	_	_	_	_
8	lineage	lineage	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
9	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
10	restricted	restrict	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
11	transactivators	transactivator	NOUN	NNS	Number=Plur	_	_	_	_
12	may	may	AUX	MD	VerbForm=Fin	_	_	_	_
13	underlie	underlie	VERB	VB	VerbForm=Inf	_	_	_	_
14	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
15	binary	binary	ADJ	JJ	Degree=Pos	_	_	_	_
16	fate	fate	NOUN	NN	Number=Sing	_	_	_	_
17	decisions	decision	NOUN	NNS	Number=Plur	_	_	_	_
18	of	of	ADP	IN	_	_	_	_	_
19	hematopoietic	hematopoietic	ADJ	JJ	Degree=Pos	_	_	_	_
20	progenitors	progenitor	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
21	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 2324
# text = Document 003003184 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	003003184	003003184	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 2325
# text = HIV-1 envelope glycoproteins induce activation of activated protein-1 in CD4+ T cells [published erratum appears in J Biol Chem 1995 Dec 1;270(48):29038] Activation of CD4 positive T cells is a primary requirement for human immunodeficiency virus (HIV) entry, efficient HIV replication, and progression to AIDS, Utilizing CD4 positive T cell lines and purified T cells from normal individuals, we have demonstrated that native envelope glycoproteins of HIV, gp 160, can induce activation of transcription factor, activated protein-1 (AP-1).
1	HIV	Hiv	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
2	-	-	PUNCT	:	_	_	_	_	SpaceAfter=No
3	1	1	NUM	CD	NumType=Card	_	_	_	_
4	envelope	envelope	NOUN	NN	Number=Sing	_	_	_	_
5	glycoproteins	glycoprotein	NOUN	NNS	Number=Plur	_	_	_	_
6	induce	induce	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
7	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
8	of	of	ADP	IN	_	_	_	_	_
9	activated	activated	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
10	protein	protein	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
11	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
12	1	1	NUM	CD	NumType=Card	_	_	_	_
13	in	in	ADP	IN	_	_	_	_	_
14	CD4	CD4	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
15	+	+	SYM	SYM	_	_	_	_	_
16	T	t	NUM	CD	NumType=Card	_	_	_	_
17	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
18	[	[	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
19	published	publish	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
20	erratum	erratum	NOUN	NN	Number=Sing	_	_	_	_
21	appears	appear	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
22	in	in	ADP	IN	_	_	_	_	_
23	J	j	PROPN	NNP	Number=Sing	_	_	_	_
24	Biol	Biol	PROPN	NNP	Number=Sing	_	_	_	_
25	Chem	Chem	PROPN	NNP	Number=Sing	_	_	_	_
26	1995	1995	NUM	CD	NumType=Card	_	_	_	_
27	Dec	Dec	PROPN	NNP	Number=Sing	_	_	_	_
28	1;270	1;270	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
29	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
30	48	48	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
31	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
32	:29038	:29038	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
33	]	]	PUNCT	-RRB-	_	_	_	_	SpacesAfter=\s\n
34	Activation	Activation	NOUN	NN	Number=Sing	_	_	_	_
35	of	of	ADP	IN	_	_	_	_	_
36	CD4	CD4	NUM	CD	NumType=Card	_	_	_	_
37	positive	positive	ADJ	JJ	Degree=Pos	_	_	_	_
38	T	t	PROPN	NNP	Number=Sing	_	_	_	_
39	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
40	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
41	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
42	primary	primary	ADJ	JJ	Degree=Pos	_	_	_	_
43	requirement	requirement	NOUN	NN	Number=Sing	_	_	_	_
44	for	for	ADP	IN	_	_	_	_	_
45	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
46	immunodeficiency	immunodeficiency	NOUN	NN	Number=Sing	_	_	_	_
47	virus	virus	NOUN	NN	Number=Sing	_	_	_	_
48	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
49	HIV	HIV	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
50	)	)	PUNCT	-RRB-	_	_	_	_	_
51	entry	entry	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
52	,	,	PUNCT	,	_	_	_	_	_
53	efficient	efficient	ADJ	JJ	Degree=Pos	_	_	_	_
54	HIV	Hiv	NOUN	NN	Number=Sing	_	_	_	_
55	replication	replication	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
56	,	,	PUNCT	,	_	_	_	_	_
57	and	and	CCONJ	CC	_	_	_	_	_
58	progression	progression	NOUN	NN	Number=Sing	_	_	_	_
59	to	to	ADP	IN	_	_	_	_	_
60	AIDS	aids	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
61	,	,	PUNCT	,	_	_	_	_	_
62	Utilizing	Utilize	PROPN	NNP	Number=Sing	_	_	_	_
63	CD4	CD4	PROPN	NNP	Number=Sing	_	_	_	_
64	positive	positive	ADJ	JJ	Degree=Pos	_	_	_	_
65	T	t	NUM	CD	NumType=Card	_	_	_	_
66	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
67	lines	line	NOUN	NNS	Number=Plur	_	_	_	_
68	and	and	CCONJ	CC	_	_	_	_	_
69	purified	purify	ADJ	JJ	Degree=Pos	_	_	_	_
70	T	t	PROPN	NNP	Number=Sing	_	_	_	_
71	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
72	from	from	ADP	IN	_	_	_	_	_
73	normal	normal	ADJ	JJ	Degree=Pos	_	_	_	_
74	individuals	individual	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
75	,	,	PUNCT	,	_	_	_	_	_
76	we	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
77	have	have	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
78	demonstrated	demonstrate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
79	that	that	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
80	native	native	ADJ	JJ	Degree=Pos	_	_	_	_
81	envelope	envelope	NOUN	NN	Number=Sing	_	_	_	_
82	glycoproteins	glycoprotein	NOUN	NNS	Number=Plur	_	_	_	_
83	of	of	ADP	IN	_	_	_	_	_
84	HIV	HIV	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
85	,	,	PUNCT	,	_	_	_	_	_
86	gp	gp	NOUN	NN	Number=Sing	_	_	_	_
87	160	160	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
88	,	,	PUNCT	,	_	_	_	_	_
89	can	can	AUX	MD	VerbForm=Fin	_	_	_	_
90	induce	induce	VERB	VB	VerbForm=Inf	_	_	_	_
91	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
92	of	of	ADP	IN	_	_	_	_	_
93	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
94	factor	factor	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
95	,	,	PUNCT	,	_	_	_	_	_
96	activated	activate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
97	protein	protein	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
98	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
99	1	1	NUM	CD	NumType=Card	_	_	_	_
100	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
101	AP	ap	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
102	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
103	1	1	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
104	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
105	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2326
# text = The stimulatory effects of gp160 are mediated through the CD4 molecule, since treatment of gp160 with soluble CD4-IgG abrogates its activity, and CD4 negative T cell lines fail to be stimulated with gp160.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	stimulatory	stimulatory	ADJ	JJ	Degree=Pos	_	_	_	_
3	effects	effect	NOUN	NNS	Number=Plur	_	_	_	_
4	of	of	ADP	IN	_	_	_	_	_
5	gp160	gp160	NOUN	NN	Number=Sing	_	_	_	_
6	are	be	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
7	mediated	mediate	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
8	through	through	ADP	IN	_	_	_	_	_
9	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
10	CD4	CD4	PROPN	NNP	Number=Sing	_	_	_	_
11	molecule	molecule	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
12	,	,	PUNCT	,	_	_	_	_	_
13	since	since	ADP	IN	_	_	_	_	_
14	treatment	treatment	NOUN	NN	Number=Sing	_	_	_	_
15	of	of	ADP	IN	_	_	_	_	_
16	gp160	gp160	NUM	CD	NumType=Card	_	_	_	_
17	with	with	ADP	IN	_	_	_	_	_
18	soluble	soluble	ADJ	JJ	Degree=Pos	_	_	_	_
19	CD4	CD4	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
20	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
21	IgG	IgG	PRON	NN	Number=Sing	_	_	_	_
22	abrogates	abrogate	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
23	its	its	PRON	PRP$	Gender=Neut|Number=Sing|Person=3|Poss=Yes|PronType=Prs	_	_	_	_
24	activity	activity	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
25	,	,	PUNCT	,	_	_	_	_	_
26	and	and	CCONJ	CC	_	_	_	_	_
27	CD4	CD4	NUM	CD	NumType=Card	_	_	_	_
28	negative	negative	ADJ	JJ	Degree=Pos	_	_	_	_
29	T	t	NOUN	NN	Number=Sing	_	_	_	_
30	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
31	lines	line	NOUN	NNS	Number=Plur	_	_	_	_
32	fail	fail	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
33	to	to	PART	TO	_	_	_	_	_
34	be	be	AUX	VB	VerbForm=Inf	_	_	_	_
35	stimulated	stimulate	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
36	with	with	ADP	IN	_	_	_	_	_
37	gp160	gp160	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
38	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2327
# text = Immunoprecipitation of the gp 160-induced nuclear extracts with polyclonal antibodies to Fos and Jun proteins indicates that AP-1 complex is comprised of members of these family of proteins.
1	Immunoprecipitation	Immunoprecipitation	NOUN	NN	Number=Sing	_	_	_	_
2	of	of	ADP	IN	_	_	_	_	_
3	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
4	gp	gp	NOUN	NN	Number=Sing	_	_	_	_
5	160	160	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
6	-	-	PUNCT	:	_	_	_	_	SpaceAfter=No
7	induced	induce	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
8	nuclear	nuclear	ADJ	JJ	Degree=Pos	_	_	_	_
9	extracts	extract	NOUN	NNS	Number=Plur	_	_	_	_
10	with	with	ADP	IN	_	_	_	_	_
11	polyclonal	polyclonal	ADJ	JJ	Degree=Pos	_	_	_	_
12	antibodies	antibody	NOUN	NNS	Number=Plur	_	_	_	_
13	to	to	ADP	IN	_	_	_	_	_
14	Fos	Fos	PROPN	NNP	Number=Sing	_	_	_	_
15	and	and	CCONJ	CC	_	_	_	_	_
16	Jun	Jun	PROPN	NNP	Number=Sing	_	_	_	_
17	proteins	protein	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
18	indicates	indicate	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
19	that	that	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
20	AP	ap	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
21	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
22	1	1	NUM	CD	NumType=Card	_	_	_	_
23	complex	complex	NOUN	NN	Number=Sing	_	_	_	_
24	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
25	comprised	comprise	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
26	of	of	ADP	IN	_	_	_	_	_
27	members	member	NOUN	NNS	Number=Plur	_	_	_	_
28	of	of	ADP	IN	_	_	_	_	_
29	these	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
30	family	family	NOUN	NN	Number=Sing	_	_	_	_
31	of	of	ADP	IN	_	_	_	_	_
32	proteins	protein	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
33	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2328
# text = The gp160-induced AP-1 complex is dependent upon protein tyrosine phosphorylation and is protein synthesis-independent.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	gp160	gp160	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
3	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
4	induced	induce	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
5	AP	ap	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
6	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
7	1	1	NUM	CD	NumType=Card	_	_	_	_
8	complex	complex	NOUN	NN	Number=Sing	_	_	_	_
9	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
10	dependent	dependent	ADJ	JJ	Degree=Pos	_	_	_	_
11	upon	upon	ADP	IN	_	_	_	_	_
12	protein	protein	NOUN	NN	Number=Sing	_	_	_	_
13	tyrosine	tyrosine	NOUN	NN	Number=Sing	_	_	_	_
14	phosphorylation	phosphorylation	NOUN	NN	Number=Sing	_	_	_	_
15	and	and	CCONJ	CC	_	_	_	_	_
16	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
17	protein	protein	NOUN	NN	Number=Sing	_	_	_	_
18	synthesis	synthesis	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
19	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
20	independent	independent	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
21	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2329
# text = This stimulation can also be abolished by inhibitors of protein kinase C, but it is unaffected by calcium channel blocker or cyclosporine A.
1	This	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
2	stimulation	stimulation	NOUN	NN	Number=Sing	_	_	_	_
3	can	can	AUX	MD	VerbForm=Fin	_	_	_	_
4	also	also	ADV	RB	_	_	_	_	_
5	be	be	AUX	VB	VerbForm=Inf	_	_	_	_
6	abolished	abolish	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
7	by	by	ADP	IN	_	_	_	_	_
8	inhibitors	inhibitor	NOUN	NNS	Number=Plur	_	_	_	_
9	of	of	ADP	IN	_	_	_	_	_
10	protein	protein	NOUN	NN	Number=Sing	_	_	_	_
11	kinase	kinase	NOUN	NN	Number=Sing	_	_	_	_
12	C	C	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
13	,	,	PUNCT	,	_	_	_	_	_
14	but	but	CCONJ	CC	_	_	_	_	_
15	it	it	PRON	PRP	Case=Nom|Gender=Neut|Number=Sing|Person=3|PronType=Prs	_	_	_	_
16	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
17	unaffected	unaffect	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
18	by	by	ADP	IN	_	_	_	_	_
19	calcium	calcium	NOUN	NN	Number=Sing	_	_	_	_
20	channel	channel	NOUN	NN	Number=Sing	_	_	_	_
21	blocker	blocker	NOUN	NN	Number=Sing	_	_	_	_
22	or	or	CCONJ	CC	_	_	_	_	_
23	cyclosporine	cyclosporine	NOUN	NN	Number=Sing	_	_	_	_
24	A	a	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
25	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2330
# text = This gp160 treatment adversely affects the functional capabilities of T cells: pre-treatment of CD4+
1	This	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
2	gp160	gp160	NUM	CD	NumType=Card	_	_	_	_
3	treatment	treatment	NOUN	NN	Number=Sing	_	_	_	_
4	adversely	adversely	ADV	RB	_	_	_	_	_
5	affects	affect	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
6	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
7	functional	functional	ADJ	JJ	Degree=Pos	_	_	_	_
8	capabilities	capability	NOUN	NNS	Number=Plur	_	_	_	_
9	of	of	ADP	IN	_	_	_	_	_
10	T	t	PROPN	NNP	Number=Sing	_	_	_	_
11	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
12	:	:	PUNCT	:	_	_	_	_	_
13	pre-treatment	pre-treatment	NOUN	NN	Number=Sing	_	_	_	_
14	of	of	ADP	IN	_	_	_	_	_
15	CD4	CD4	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
16	+	+	SYM	SYM	_	_	_	_	_

# sent_id = 2331
# text = T cells with gp160 for 4 h at 37 degrees C inhibited anti-CD3-induced interleukin-2 secretion.
1	T	t	ADJ	JJ	Degree=Pos	_	_	_	_
2	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
3	with	with	ADP	IN	_	_	_	_	_
4	gp160	gp160	NUM	CD	NumType=Card	_	_	_	_
5	for	for	ADP	IN	_	_	_	_	_
6	4	4	NUM	CD	NumType=Card	_	_	_	_
7	h	h	NOUN	NN	Number=Sing	_	_	_	_
8	at	at	ADP	IN	_	_	_	_	_
9	37	37	NUM	CD	NumType=Card	_	_	_	_
10	degrees	degree	NOUN	NNS	Number=Plur	_	_	_	_
11	C	class	PROPN	NNP	Number=Sing	_	_	_	_
12	inhibited	inhibit	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
13	anti-CD3	anti-CD3	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
14	-induced	-induce	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
15	interleukin	interleukin	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
16	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
17	2	2	NUM	CD	NumType=Card	_	_	_	_
18	secretion	secretion	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
19	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2332
# text = Effects similar to gp160 were seen with anti-CD4 mAb.
1	Effects	Effect	PROPN	NNPS	Number=Plur	_	_	_	_
2	similar	similar	ADJ	JJ	Degree=Pos	_	_	_	_
3	to	to	ADP	IN	_	_	_	_	_
4	gp160	gp160	NUM	CD	NumType=Card	_	_	_	_
5	were	be	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
6	seen	see	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
7	with	with	ADP	IN	_	_	_	_	_
8	anti-CD4	anti-CD4	NUM	CD	NumType=Card	_	_	_	_
9	mAb	mAb	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
10	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2333
# text = The aberrant activation of AP-1 by gp160 in CD4 positive T cells could result in up-regulation of cytokines containing AP-1 sites, e.g. interleukin-3 and granulocyte macrophage colony-stimulating factor, and concurrently lead to T cell unresponsiveness by inhibiting interleukin-2 secretion.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	aberrant	aberrant	ADJ	JJ	Degree=Pos	_	_	_	_
3	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
4	of	of	ADP	IN	_	_	_	_	_
5	AP	ap	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
6	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
7	1	1	NUM	CD	NumType=Card	_	_	_	_
8	by	by	ADP	IN	_	_	_	_	_
9	gp160	gp160	NUM	CD	NumType=Card	_	_	_	_
10	in	in	ADP	IN	_	_	_	_	_
11	CD4	CD4	NUM	CD	NumType=Card	_	_	_	_
12	positive	positive	ADJ	JJ	Degree=Pos	_	_	_	_
13	T	t	PROPN	NNP	Number=Sing	_	_	_	_
14	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
15	could	could	AUX	MD	VerbForm=Fin	_	_	_	_
16	result	result	VERB	VB	VerbForm=Inf	_	_	_	_
17	in	in	ADP	IN	_	_	_	_	_
18	up	up	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
19	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
20	regulation	regulation	NOUN	NN	Number=Sing	_	_	_	_
21	of	of	ADP	IN	_	_	_	_	_
22	cytokines	cytokine	NOUN	NNS	Number=Plur	_	_	_	_
23	containing	contain	VERB	VBG	VerbForm=Ger	_	_	_	_
24	AP	ap	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
25	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
26	1	1	NUM	CD	NumType=Card	_	_	_	_
27	sites	site	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
28	,	,	PUNCT	,	_	_	_	_	_
29	e.g.	e.g.	X	FW	_	_	_	_	_
30	interleukin	interleukin	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
31	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
32	3	3	NUM	CD	NumType=Card	_	_	_	_
33	and	and	CCONJ	CC	_	_	_	_	_
34	granulocyte	granulocyte	NOUN	NN	Number=Sing	_	_	_	_
35	macrophage	macrophage	NOUN	NN	Number=Sing	_	_	_	_
36	colony	colony	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
37	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
38	stimulating	stimulating	VERB	VBG	VerbForm=Ger	_	_	_	_
39	factor	factor	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
40	,	,	PUNCT	,	_	_	_	_	_
41	and	and	CCONJ	CC	_	_	_	_	_
42	concurrently	concurrently	ADV	RB	_	_	_	_	_
43	lead	lead	ADV	RB	_	_	_	_	_
44	to	to	ADP	IN	_	_	_	_	_
45	T	t	PROPN	NNP	Number=Sing	_	_	_	_
46	cell	cell	PROPN	NNP	Number=Sing	_	_	_	_
47	unresponsiveness	unresponsiveness	NOUN	NN	Number=Sing	_	_	_	_
48	by	by	SCONJ	IN	_	_	_	_	_
49	inhibiting	inhibit	VERB	VBG	VerbForm=Ger	_	_	_	_
50	interleukin	interleukin	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
51	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
52	2	2	NUM	CD	NumType=Card	_	_	_	_
53	secretion	secretion	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
54	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 2334
# text = Document 003003190 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	003003190	003003190	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 2335
# text = [The role of glucocorticoid receptors and HLA antigens in the pathogenesis of Cushing's syndrome] Lymphocytic levels of glucocorticoid receptors were evaluated in 114 patients suffering from Icenko-Cushing's syndrome.
1	[	[	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
2	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
3	role	role	NOUN	NN	Number=Sing	_	_	_	_
4	of	of	ADP	IN	_	_	_	_	_
5	glucocorticoid	glucocorticoid	ADJ	JJ	Degree=Pos	_	_	_	_
6	receptors	receptor	NOUN	NNS	Number=Plur	_	_	_	_
7	and	and	CCONJ	CC	_	_	_	_	_
8	HLA	Hla	ADJ	JJ	Degree=Pos	_	_	_	_
9	antigens	antigen	NOUN	NNS	Number=Plur	_	_	_	_
10	in	in	ADP	IN	_	_	_	_	_
11	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
12	pathogenesis	pathogenesis	NOUN	NN	Number=Sing	_	_	_	_
13	of	of	ADP	IN	_	_	_	_	_
14	Cushing	Cushing	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
15	's	's	PART	POS	_	_	_	_	_
16	syndrome	syndrome	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
17	]	]	PUNCT	-RRB-	_	_	_	_	SpacesAfter=\s\n
18	Lymphocytic	Lymphocytic	ADJ	JJ	Degree=Pos	_	_	_	_
19	levels	level	NOUN	NNS	Number=Plur	_	_	_	_
20	of	of	ADP	IN	_	_	_	_	_
21	glucocorticoid	glucocorticoid	ADJ	JJ	Degree=Pos	_	_	_	_
22	receptors	receptor	NOUN	NNS	Number=Plur	_	_	_	_
23	were	be	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
24	evaluated	evaluate	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
25	in	in	ADP	IN	_	_	_	_	_
26	114	114	NUM	CD	NumType=Card	_	_	_	_
27	patients	patient	NOUN	NNS	Number=Plur	_	_	_	_
28	suffering	suffer	VERB	VBG	VerbForm=Ger	_	_	_	_
29	from	from	ADP	IN	_	_	_	_	_
30	Icenko	Icenko	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
31	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
32	Cushing	Cushing	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
33	's	's	PART	POS	_	_	_	_	_
34	syndrome	syndrome	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
35	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2336
# text = Incidence of HLA antigens was determined in 94 of them.
1	Incidence	Incidence	NOUN	NN	Number=Sing	_	_	_	_
2	of	of	ADP	IN	_	_	_	_	_
3	HLA	Hla	PROPN	NNP	Number=Sing	_	_	_	_
4	antigens	antigen	NOUN	NNS	Number=Plur	_	_	_	_
5	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
6	determined	determine	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
7	in	in	ADP	IN	_	_	_	_	_
8	94	94	NUM	CD	NumType=Card	_	_	_	_
9	of	of	ADP	IN	_	_	_	_	_
10	them	they	PRON	PRP	Case=Acc|Number=Plur|Person=3|PronType=Prs	_	_	_	SpaceAfter=No
11	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2337
# text = A significant rise of A10 and B27 antigen incidence compared to that in normal subjects allows these antigens to be considered genetic markers of Icenko-Cushing's syndrome.
1	A	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
2	significant	significant	ADJ	JJ	Degree=Pos	_	_	_	_
3	rise	rise	NOUN	NN	Number=Sing	_	_	_	_
4	of	of	ADP	IN	_	_	_	_	_
5	A10	A10	NUM	CD	NumType=Card	_	_	_	_
6	and	and	CCONJ	CC	_	_	_	_	_
7	B27	B27	NUM	CD	NumType=Card	_	_	_	_
8	antigen	antigen	ADJ	JJ	Degree=Pos	_	_	_	_
9	incidence	incidence	NOUN	NN	Number=Sing	_	_	_	_
10	compared	compare	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
11	to	to	ADP	IN	_	_	_	_	_
12	that	that	PRON	DT	Number=Sing|PronType=Dem	_	_	_	_
13	in	in	ADP	IN	_	_	_	_	_
14	normal	normal	ADJ	JJ	Degree=Pos	_	_	_	_
15	subjects	subjects	NOUN	NNS	Number=Plur	_	_	_	_
16	allows	allow	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
17	these	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
18	antigens	antigen	NOUN	NNS	Number=Plur	_	_	_	_
19	to	to	PART	TO	_	_	_	_	_
20	be	be	AUX	VB	VerbForm=Inf	_	_	_	_
21	considered	consider	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
22	genetic	genetic	ADJ	JJ	Degree=Pos	_	_	_	_
23	markers	marker	NOUN	NNS	Number=Plur	_	_	_	_
24	of	of	ADP	IN	_	_	_	_	_
25	Icenko	Icenko	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
26	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
27	Cushing	Cushing	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
28	's	's	PART	POS	_	_	_	_	_
29	syndrome	syndrome	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
30	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2338
# text = The levels of glucocorticoid receptors in lymphocytes of the patients are lower than in normal subjects both in the active stage of the disease and following bilateral total adrenalectomy.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	levels	level	NOUN	NNS	Number=Plur	_	_	_	_
3	of	of	ADP	IN	_	_	_	_	_
4	glucocorticoid	glucocorticoid	ADJ	JJ	Degree=Pos	_	_	_	_
5	receptors	receptor	NOUN	NNS	Number=Plur	_	_	_	_
6	in	in	ADP	IN	_	_	_	_	_
7	lymphocytes	lymphocyte	NOUN	NNS	Number=Plur	_	_	_	_
8	of	of	ADP	IN	_	_	_	_	_
9	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
10	patients	patient	NOUN	NNS	Number=Plur	_	_	_	_
11	are	be	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
12	lower	lower	ADJ	JJR	Degree=Cmp	_	_	_	_
13	than	than	ADP	IN	_	_	_	_	_
14	in	in	ADP	IN	_	_	_	_	_
15	normal	normal	ADJ	JJ	Degree=Pos	_	_	_	_
16	subjects	subjects	NOUN	NNS	Number=Plur	_	_	_	_
17	both	both	CCONJ	CC	_	_	_	_	_
18	in	in	ADP	IN	_	_	_	_	_
19	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
20	active	active	ADJ	JJ	Degree=Pos	_	_	_	_
21	stage	stage	NOUN	NN	Number=Sing	_	_	_	_
22	of	of	ADP	IN	_	_	_	_	_
23	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
24	disease	disease	NOUN	NN	Number=Sing	_	_	_	_
25	and	and	CCONJ	CC	_	_	_	_	_
26	following	follow	VERB	VBG	VerbForm=Ger	_	_	_	_
27	bilateral	bilateral	ADJ	JJ	Degree=Pos	_	_	_	_
28	total	total	ADJ	JJ	Degree=Pos	_	_	_	_
29	adrenalectomy	adrenalectomy	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
30	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2339
# text = The patients carrying B27 antigen had lymphocytic receptor concentrations under the levels of such in patients free of the antigen carriage.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	patients	patient	NOUN	NN	Number=Sing	_	_	_	_
3	carrying	carry	VERB	VBG	VerbForm=Ger	_	_	_	_
4	B27	B27	NUM	CD	NumType=Card	_	_	_	_
5	antigen	antigen	NOUN	NNS	Number=Plur	_	_	_	_
6	had	have	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
7	lymphocytic	lymphocytic	ADJ	JJ	Degree=Pos	_	_	_	_
8	receptor	receptor	NOUN	NN	Number=Sing	_	_	_	_
9	concentrations	concentration	NOUN	NNS	Number=Plur	_	_	_	_
10	under	under	ADP	IN	_	_	_	_	_
11	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
12	levels	level	NOUN	NNS	Number=Plur	_	_	_	_
13	of	of	ADP	IN	_	_	_	_	_
14	such	such	ADJ	JJ	Degree=Pos	_	_	_	_
15	in	in	ADP	IN	_	_	_	_	_
16	patients	patient	NOUN	NNS	Number=Plur	_	_	_	_
17	free	free	ADJ	JJ	Degree=Pos	_	_	_	_
18	of	of	ADP	IN	_	_	_	_	_
19	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
20	antigen	antigen	ADJ	JJ	Degree=Pos	_	_	_	_
21	carriage	carriage	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
22	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2340
# text = Antigen B27 seems to be a cause of lower levels of glucocorticoid receptors in blood lymphocytes.
1	Antigen	Antigen	ADJ	JJ	Degree=Pos	_	_	_	_
2	B27	B27	NOUN	NN	Number=Sing	_	_	_	_
3	seems	seem	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
4	to	to	PART	TO	_	_	_	_	_
5	be	be	AUX	VB	VerbForm=Inf	_	_	_	_
6	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
7	cause	cause	NOUN	NN	Number=Sing	_	_	_	_
8	of	of	ADP	IN	_	_	_	_	_
9	lower	lower	ADJ	JJ	Degree=Pos	_	_	_	_
10	levels	level	NOUN	NNS	Number=Plur	_	_	_	_
11	of	of	ADP	IN	_	_	_	_	_
12	glucocorticoid	glucocorticoid	ADJ	JJ	Degree=Pos	_	_	_	_
13	receptors	receptor	NOUN	NNS	Number=Plur	_	_	_	_
14	in	in	ADP	IN	_	_	_	_	_
15	blood	blood	NOUN	NN	Number=Sing	_	_	_	_
16	lymphocytes	lymphocyte	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
17	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 2341
# text = Document 003003197 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	003003197	003003197	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 2342
# text = Human immunodeficiency virus-associated Hodgkin's disease derives from post-germinal center B cells.
1	Human	human	ADJ	JJ	Degree=Pos	_	_	_	_
2	immunodeficiency	immunodeficiency	NOUN	NN	Number=Sing	_	_	_	_
3	virus	virus	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
4	-associated	-associate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
5	Hodgkin	Hodgkin	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
6	's	's	PART	POS	_	_	_	_	_
7	disease	disease	NOUN	NN	Number=Sing	_	_	_	_
8	derives	derive	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
9	from	from	ADP	IN	_	_	_	_	_
10	post	post	X	AFX	_	_	_	_	SpaceAfter=No
11	-germinal	-germinal	ADJ	JJ	Degree=Pos	_	_	_	_
12	center	center	NOUN	NN	Number=Sing	_	_	_	_
13	B	b	ADJ	JJ	Degree=Pos	_	_	_	_
14	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
15	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 2343
# text = Human immunodeficiency virus-associated Hodgkin's disease (HIV-HD) displays several peculiarities when compared with HD of the general population.
1	Human	human	ADJ	JJ	Degree=Pos	_	_	_	_
2	immunodeficiency	immunodeficiency	NOUN	NN	Number=Sing	_	_	_	_
3	virus-associated	virus-associate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
4	Hodgkin	Hodgkin	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
5	's	's	PART	POS	_	_	_	_	_
6	disease	disease	NOUN	NN	Number=Sing	_	_	_	_
7	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
8	HIV	Hiv	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
9	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
10	HD	hd	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
11	)	)	PUNCT	-RRB-	_	_	_	_	_
12	displays	display	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
13	several	several	ADJ	JJ	Degree=Pos	_	_	_	_
14	peculiarities	peculiarity	NOUN	NNS	Number=Plur	_	_	_	_
15	when	when	ADV	WRB	PronType=Int	_	_	_	_
16	compared	compare	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
17	with	with	ADP	IN	_	_	_	_	_
18	HD	hd	NOUN	NN	Number=Sing	_	_	_	_
19	of	of	ADP	IN	_	_	_	_	_
20	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
21	general	general	ADJ	JJ	Degree=Pos	_	_	_	_
22	population	population	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
23	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2344
# text = These include overrepresentation of clinically aggressive histologic types and frequent infection of Reed-Sternberg (RS) cells by Epstein-Barr virus (EBV).
1	These	these	PRON	DT	Number=Plur|PronType=Dem	_	_	_	_
2	include	include	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
3	overrepresentation	overrepresentation	NOUN	NN	Number=Sing	_	_	_	_
4	of	of	ADP	IN	_	_	_	_	_
5	clinically	clinically	ADV	RB	_	_	_	_	_
6	aggressive	aggressive	ADJ	JJ	Degree=Pos	_	_	_	_
7	histologic	histologic	NOUN	NN	Number=Sing	_	_	_	_
8	types	type	NOUN	NNS	Number=Plur	_	_	_	_
9	and	and	CCONJ	CC	_	_	_	_	_
10	frequent	frequent	ADJ	JJ	Degree=Pos	_	_	_	_
11	infection	infection	NOUN	NN	Number=Sing	_	_	_	_
12	of	of	ADP	IN	_	_	_	_	_
13	Reed	ree	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
14	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
15	Sternberg	Sternberg	NOUN	NN	Number=Sing	_	_	_	_
16	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
17	RS	rs	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
18	)	)	PUNCT	-RRB-	_	_	_	_	_
19	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
20	by	by	ADP	IN	_	_	_	_	_
21	Epstein	Epstein	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
22	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
23	Barr	Barr	PROPN	NNP	Number=Sing	_	_	_	_
24	virus	virus	NOUN	NN	Number=Sing	_	_	_	_
25	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
26	EBV	EBV	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
27	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
28	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2345
# text = Recently, we have reported that the histogenesis of HD of the general population may be assessed by monitoring the expression pattern of BCL-6, a transcription factor expressed in germinal center (GC) B cells, and of CD138/syndecan-1 (syn-1), a proteoglycan associated with post-GC, terminal B-cell differentiation.
1	Recently	recently	ADV	RB	_	_	_	_	SpaceAfter=No
2	,	,	PUNCT	,	_	_	_	_	_
3	we	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
4	have	have	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
5	reported	report	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
6	that	that	SCONJ	IN	_	_	_	_	_
7	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
8	histogenesis	histogenesis	NOUN	NN	Number=Sing	_	_	_	_
9	of	of	ADP	IN	_	_	_	_	_
10	HD	hd	NOUN	NN	Number=Sing	_	_	_	_
11	of	of	ADP	IN	_	_	_	_	_
12	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
13	general	general	ADJ	JJ	Degree=Pos	_	_	_	_
14	population	population	NOUN	NN	Number=Sing	_	_	_	_
15	may	may	AUX	MD	VerbForm=Fin	_	_	_	_
16	be	be	AUX	VB	VerbForm=Inf	_	_	_	_
17	assessed	assess	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
18	by	by	SCONJ	IN	_	_	_	_	_
19	monitoring	monitor	VERB	VBG	VerbForm=Ger	_	_	_	_
20	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
21	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
22	pattern	pattern	NOUN	NN	Number=Sing	_	_	_	_
23	of	of	ADP	IN	_	_	_	_	_
24	BCL	BCL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
25	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
26	6	6	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
27	,	,	PUNCT	,	_	_	_	_	_
28	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
29	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
30	factor	factor	NOUN	NN	Number=Sing	_	_	_	_
31	expressed	express	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
32	in	in	ADP	IN	_	_	_	_	_
33	germinal	germinal	ADJ	JJ	Degree=Pos	_	_	_	_
34	center	center	NOUN	NN	Number=Sing	_	_	_	_
35	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
36	GC	GC	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
37	)	)	PUNCT	-RRB-	_	_	_	_	_
38	B	b	ADJ	JJ	Degree=Pos	_	_	_	_
39	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
40	,	,	PUNCT	,	_	_	_	_	_
41	and	and	CCONJ	CC	_	_	_	_	_
42	of	of	ADP	IN	_	_	_	_	_
43	CD138/syndecan	CD138/syndecan	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
44	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
45	1	1	NUM	CD	NumType=Card	_	_	_	_
46	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
47	syn	syn	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
48	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
49	1	1	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
50	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
51	,	,	PUNCT	,	_	_	_	_	_
52	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
53	proteoglycan	proteoglycan	ADJ	JJ	Degree=Pos	_	_	_	_
54	associated	associate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
55	with	with	ADP	IN	_	_	_	_	_
56	post	post	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
57	-GC	-gc	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
58	,	,	PUNCT	,	_	_	_	_	_
59	terminal	terminal	NOUN	NN	Number=Sing	_	_	_	_
60	B	b	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
61	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
62	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
63	differentiation	differentiation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
64	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2346
# text = In this study, we have applied these two markers to the study of HIV-HD histogenesis and correlated their expression status to the virologic features of this disease.
1	In	in	ADP	IN	_	_	_	_	_
2	this	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
3	study	study	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
4	,	,	PUNCT	,	_	_	_	_	_
5	we	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
6	have	have	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
7	applied	apply	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
8	these	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
9	two	two	NUM	CD	NumType=Card	_	_	_	_
10	markers	marker	NOUN	NNS	Number=Plur	_	_	_	_
11	to	to	ADP	IN	_	_	_	_	_
12	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
13	study	study	NOUN	NN	Number=Sing	_	_	_	_
14	of	of	ADP	IN	_	_	_	_	_
15	HIV	HIV	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
16	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
17	HD	HD	NOUN	NN	Number=Sing	_	_	_	_
18	histogenesis	histogenesis	NOUN	NN	Number=Sing	_	_	_	_
19	and	and	CCONJ	CC	_	_	_	_	_
20	correlated	correlate	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
21	their	they	PRON	PRP$	Number=Plur|Person=3|Poss=Yes|PronType=Prs	_	_	_	_
22	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
23	status	status	NOUN	NN	Number=Sing	_	_	_	_
24	to	to	ADP	IN	_	_	_	_	_
25	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
26	virologic	virologic	NOUN	NN	Number=Sing	_	_	_	_
27	features	feature	NOUN	NNS	Number=Plur	_	_	_	_
28	of	of	ADP	IN	_	_	_	_	_
29	this	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
30	disease	disease	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
31	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2347
# text = We have found that RS cells of all histologic categories of HIV-HD consistently display the BCL-6(-)/syn-1(+) phenotype and thus reflect post-GC B cells.
1	We	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
2	have	have	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
3	found	find	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
4	that	that	SCONJ	IN	_	_	_	_	_
5	RS	rs	ADJ	JJ	Degree=Pos	_	_	_	_
6	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
7	of	of	ADP	IN	_	_	_	_	_
8	all	all	DET	DT	_	_	_	_	_
9	histologic	histologic	ADJ	JJ	Degree=Pos	_	_	_	_
10	categories	category	NOUN	NNS	Number=Plur	_	_	_	_
11	of	of	ADP	IN	_	_	_	_	_
12	HIV	HIV	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
13	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
14	HD	HD	PROPN	NNP	Number=Sing	_	_	_	_
15	consistently	consistently	ADV	RB	_	_	_	_	_
16	display	display	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
17	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
18	BCL	BCL	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
19	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
20	6	6	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
21	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
22	-)	-)	PUNCT	.	_	_	_	_	SpaceAfter=No
23	/syn	/syn	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
24	-1	-1	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
25	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
26	+)	+)	SYM	NFP	_	_	_	_	_
27	phenotype	phenotype	NOUN	NN	Number=Sing	_	_	_	_
28	and	and	CCONJ	CC	_	_	_	_	_
29	thus	thus	ADV	RB	_	_	_	_	_
30	reflect	reflect	VERB	VB	VerbForm=Inf	_	_	_	_
31	post	post	X	AFX	_	_	_	_	SpaceAfter=No
32	-GC	-gc	ADJ	JJ	Degree=Pos	_	_	_	_
33	B	b	NOUN	NN	Number=Sing	_	_	_	_
34	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
35	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2348
# text = Although BCL-6(-)/syn-1(+)RS cells of HIV-HD express CD40, they are not surrounded by CD40 ligand-positive (CD40L+) reactive T lymphocytes, which, in HD of the general population, are thought to regulate the disease phenotype through CD40/CD40L interactions.
1	Although	although	SCONJ	IN	_	_	_	_	_
2	BCL	BCL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
3	-6(	-6(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
4	-)	-)	PUNCT	.	_	_	_	_	SpaceAfter=No
5	/syn	/syn	VERB	VB	Mood=Imp|VerbForm=Fin	_	_	_	SpaceAfter=No
6	-1(+)	-1(+)	SYM	NFP	_	_	_	_	SpaceAfter=No
7	RS	R	ADJ	JJ	Degree=Pos	_	_	_	_
8	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
9	of	of	ADP	IN	_	_	_	_	_
10	HIV	HIV	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
11	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
12	HD	HD	NOUN	NN	Number=Sing	_	_	_	_
13	express	express	NOUN	NN	Number=Sing	_	_	_	_
14	CD40	CD40	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
15	,	,	PUNCT	,	_	_	_	_	_
16	they	they	PRON	PRP	Case=Nom|Number=Plur|Person=3|PronType=Prs	_	_	_	_
17	are	be	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
18	not	not	PART	RB	_	_	_	_	_
19	surrounded	surround	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
20	by	by	ADP	IN	_	_	_	_	_
21	CD40	CD40	NUM	CD	NumType=Card	_	_	_	_
22	ligand	ligand	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
23	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
24	positive	positive	ADJ	JJ	Degree=Pos	_	_	_	_
25	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
26	CD40L	Cd40l	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
27	+	+	SYM	SYM	_	_	_	_	SpaceAfter=No
28	)	)	PUNCT	-RRB-	_	_	_	_	_
29	reactive	reactive	ADJ	JJ	Degree=Pos	_	_	_	_
30	T	t	NOUN	NN	Number=Sing	_	_	_	_
31	lymphocytes	lymphocyte	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
32	,	,	PUNCT	,	_	_	_	_	_
33	which	which	PRON	WDT	PronType=Rel	_	_	_	SpaceAfter=No
34	,	,	PUNCT	,	_	_	_	_	_
35	in	in	ADP	IN	_	_	_	_	_
36	HD	hd	NOUN	NN	Number=Sing	_	_	_	_
37	of	of	ADP	IN	_	_	_	_	_
38	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
39	general	general	ADJ	JJ	Degree=Pos	_	_	_	_
40	population	population	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
41	,	,	PUNCT	,	_	_	_	_	_
42	are	be	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
43	thought	think	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
44	to	to	PART	TO	_	_	_	_	_
45	regulate	regulate	VERB	VB	VerbForm=Inf	_	_	_	_
46	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
47	disease	disease	NOUN	NN	Number=Sing	_	_	_	_
48	phenotype	phenotype	NOUN	NN	Number=Sing	_	_	_	_
49	through	through	ADP	IN	_	_	_	_	_
50	CD40/CD40L	Cd40/cd40l	NOUN	NN	Number=Sing	_	_	_	_
51	interactions	interaction	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
52	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2349
# text = Conversely, RS cells of virtually all HIV-HD express the EBV-encoded latent membrane protein 1 (LMP1), which, being functionally homologous to CD40, may contribute, at least in part, to the modulation of the HIV-HD phenotype.
1	Conversely	Conversely	ADV	RB	_	_	_	_	SpaceAfter=No
2	,	,	PUNCT	,	_	_	_	_	_
3	RS	rs	ADJ	JJ	Degree=Pos	_	_	_	_
4	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
5	of	of	ADP	IN	_	_	_	_	_
6	virtually	virtually	ADV	RB	_	_	_	_	_
7	all	all	DET	DT	_	_	_	_	_
8	HIV	HIV	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
9	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
10	HD	HD	NOUN	NN	Number=Sing	_	_	_	_
11	express	express	NOUN	NN	Number=Sing	_	_	_	_
12	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
13	EBV	EBV	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
14	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
15	encoded	encod	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
16	latent	latent	ADJ	JJ	Degree=Pos	_	_	_	_
17	membrane	membrane	NOUN	NN	Number=Sing	_	_	_	_
18	protein	protein	NOUN	NN	Number=Sing	_	_	_	_
19	1	1	NUM	CD	NumType=Card	_	_	_	_
20	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
21	LMP1	Lmp1	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
22	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
23	,	,	PUNCT	,	_	_	_	_	_
24	which	which	PRON	WDT	PronType=Rel	_	_	_	SpaceAfter=No
25	,	,	PUNCT	,	_	_	_	_	_
26	being	be	AUX	VBG	VerbForm=Ger	_	_	_	_
27	functionally	functionally	ADV	RB	_	_	_	_	_
28	homologous	homologous	ADJ	JJ	Degree=Pos	_	_	_	_
29	to	to	ADP	IN	_	_	_	_	_
30	CD40	CD40	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
31	,	,	PUNCT	,	_	_	_	_	_
32	may	may	AUX	MD	VerbForm=Fin	_	_	_	_
33	contribute	contribute	VERB	VB	VerbForm=Inf	_	_	_	SpaceAfter=No
34	,	,	PUNCT	,	_	_	_	_	_
35	at	at	ADV	RB	_	_	_	_	_
36	least	least	ADV	RBS	Degree=Sup	_	_	_	_
37	in	in	ADP	IN	_	_	_	_	_
38	part	part	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
39	,	,	PUNCT	,	_	_	_	_	_
40	to	to	ADP	IN	_	_	_	_	_
41	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
42	modulation	modulation	NOUN	NN	Number=Sing	_	_	_	_
43	of	of	ADP	IN	_	_	_	_	_
44	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
45	HIV	Hiv	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
46	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
47	HD	hd	NOUN	NN	Number=Sing	_	_	_	_
48	phenotype	phenotype	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
49	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 2350
# text = Document 003003202 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	003003202	003003202	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 2351
# text = Inhibition of nuclear factor kappa
1	Inhibition	Inhibition	NOUN	NN	Number=Sing	_	_	_	_
2	of	of	ADP	IN	_	_	_	_	_
3	nuclear	nuclear	ADJ	JJ	Degree=Pos	_	_	_	_
4	factor	factor	NOUN	NN	Number=Sing	_	_	_	_
5	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_

# sent_id = 2352
# text = B subunit p65 mRNA accumulation in lipopolysaccharide-stimulated human monocytic cells treated with sodium salicylate.
1	B	b	NOUN	NN	Number=Sing	_	_	_	_
2	subunit	subunit	NOUN	NN	Number=Sing	_	_	_	_
3	p65	p65	NUM	CD	NumType=Card	_	_	_	_
4	mRNA	mRNa	NOUN	NN	Number=Sing	_	_	_	_
5	accumulation	accumulation	NOUN	NN	Number=Sing	_	_	_	_
6	in	in	ADP	IN	_	_	_	_	_
7	lipopolysaccharide	lipopolysaccharide	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
8	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
9	stimulated	stimulate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
10	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
11	monocytic	monocytic	ADJ	JJ	Degree=Pos	_	_	_	_
12	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
13	treated	treat	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
14	with	with	ADP	IN	_	_	_	_	_
15	sodium	sodium	NOUN	NN	Number=Sing	_	_	_	_
16	salicylate	salicylate	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
17	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 2353
# text = Lipopolysaccharide is one of the most potent trigger substances for monocytes and macrophages causing secretion of inflammatory mediators such as tumor necrosis factor and interleukin-1.
1	Lipopolysaccharide	Lipopolysaccharide	NOUN	NN	Number=Sing	_	_	_	_
2	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
3	one	one	NUM	CD	NumType=Card	_	_	_	_
4	of	of	ADP	IN	_	_	_	_	_
5	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
6	most	most	ADV	RBS	_	_	_	_	_
7	potent	potent	ADJ	JJ	Degree=Pos	_	_	_	_
8	trigger	trigger	NOUN	NN	Number=Sing	_	_	_	_
9	substances	substance	NOUN	NNS	Number=Plur	_	_	_	_
10	for	for	ADP	IN	_	_	_	_	_
11	monocytes	monocyte	NOUN	NNS	Number=Plur	_	_	_	_
12	and	and	CCONJ	CC	_	_	_	_	_
13	macrophages	macrophage	NOUN	NNS	Number=Plur	_	_	_	_
14	causing	cause	VERB	VBG	VerbForm=Ger	_	_	_	_
15	secretion	secretion	NOUN	NN	Number=Sing	_	_	_	_
16	of	of	ADP	IN	_	_	_	_	_
17	inflammatory	inflammatory	ADJ	JJ	Degree=Pos	_	_	_	_
18	mediators	mediator	NOUN	NNS	Number=Plur	_	_	_	_
19	such	such	ADJ	JJ	Degree=Pos	_	_	_	_
20	as	as	ADP	IN	_	_	_	_	_
21	tumor	tumor	NOUN	NN	Number=Sing	_	_	_	_
22	necrosis	necrosis	NOUN	NN	Number=Sing	_	_	_	_
23	factor	factor	NOUN	NN	Number=Sing	_	_	_	_
24	and	and	CCONJ	CC	_	_	_	_	_
25	interleukin	interleukin	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
26	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
27	1	1	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
28	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2354
# text = The nature of the nuclear factors involved in regulation of these cytokine genes is still unknown.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	nature	nature	NOUN	NN	Number=Sing	_	_	_	_
3	of	of	ADP	IN	_	_	_	_	_
4	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
5	nuclear	nuclear	ADJ	JJ	Degree=Pos	_	_	_	_
6	factors	factor	NOUN	NNS	Number=Plur	_	_	_	_
7	involved	involve	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
8	in	in	ADP	IN	_	_	_	_	_
9	regulation	regulation	NOUN	NN	Number=Sing	_	_	_	_
10	of	of	ADP	IN	_	_	_	_	_
11	these	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
12	cytokine	cytokine	NOUN	NN	Number=Sing	_	_	_	_
13	genes	gene	NOUN	NNS	Number=Plur	_	_	_	_
14	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
15	still	still	ADV	RB	_	_	_	_	_
16	unknown	unknown	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
17	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2355
# text = Nuclear factor kappa B (NF-kappa B; heterodimer of p50 and p65) proteins have been suggested to play an important role in gene transcription of inflammatory mediators when monocytes are stimulated with lipopolysaccharide.
1	Nuclear	nuclear	ADJ	JJ	Degree=Pos	_	_	_	_
2	factor	factor	NOUN	NN	Number=Sing	_	_	_	_
3	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_
4	B	b	NOUN	NN	Number=Sing	_	_	_	_
5	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
6	NF	Nf	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
7	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
8	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_
9	B	b	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
10	;	;	PUNCT	,	_	_	_	_	_
11	heterodimer	heterodimer	NOUN	NN	Number=Sing	_	_	_	_
12	of	of	ADP	IN	_	_	_	_	_
13	p50	p50	NUM	CD	NumType=Card	_	_	_	_
14	and	and	CCONJ	CC	_	_	_	_	_
15	p65	p65	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
16	)	)	PUNCT	-RRB-	_	_	_	_	_
17	proteins	protein	NOUN	NNS	Number=Plur	_	_	_	_
18	have	have	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
19	been	be	AUX	VBN	Tense=Past|VerbForm=Part	_	_	_	_
20	suggested	suggest	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
21	to	to	PART	TO	_	_	_	_	_
22	play	play	VERB	VB	VerbForm=Inf	_	_	_	_
23	an	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
24	important	important	ADJ	JJ	Degree=Pos	_	_	_	_
25	role	role	NOUN	NN	Number=Sing	_	_	_	_
26	in	in	ADP	IN	_	_	_	_	_
27	gene	gene	ADJ	JJ	Degree=Pos	_	_	_	_
28	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
29	of	of	ADP	IN	_	_	_	_	_
30	inflammatory	inflammatory	ADJ	JJ	Degree=Pos	_	_	_	_
31	mediators	mediator	NOUN	NNS	Number=Plur	_	_	_	_
32	when	when	ADV	WRB	PronType=Int	_	_	_	_
33	monocytes	monocyte	NOUN	NNS	Number=Plur	_	_	_	_
34	are	be	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
35	stimulated	stimulate	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
36	with	with	ADP	IN	_	_	_	_	_
37	lipopolysaccharide	lipopolysaccharide	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
38	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2356
# text = Nonsteroidal anti-inflammatory drugs such as salicylates have been used to treat symptoms of inflammation, and a new mechanism of drug action was suggested recently.
1	Nonsteroidal	Nonsteroidal	ADJ	JJ	Degree=Pos	_	_	_	_
2	anti-inflammatory	anti-inflammatory	ADJ	JJ	Degree=Pos	_	_	_	_
3	drugs	drug	NOUN	NNS	Number=Plur	_	_	_	_
4	such	such	ADJ	JJ	Degree=Pos	_	_	_	_
5	as	as	SCONJ	IN	_	_	_	_	_
6	salicylates	salicylate	NOUN	NNS	Number=Plur	_	_	_	_
7	have	have	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
8	been	be	AUX	VBN	Tense=Past|VerbForm=Part	_	_	_	_
9	used	use	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
10	to	to	PART	TO	_	_	_	_	_
11	treat	treat	VERB	VB	VerbForm=Inf	_	_	_	_
12	symptoms	symptom	NOUN	NNS	Number=Plur	_	_	_	_
13	of	of	ADP	IN	_	_	_	_	_
14	inflammation	inflammation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
15	,	,	PUNCT	,	_	_	_	_	_
16	and	and	CCONJ	CC	_	_	_	_	_
17	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
18	new	new	ADJ	JJ	Degree=Pos	_	_	_	_
19	mechanism	mechanism	NOUN	NN	Number=Sing	_	_	_	_
20	of	of	ADP	IN	_	_	_	_	_
21	drug	drug	NOUN	NN	Number=Sing	_	_	_	_
22	action	action	NOUN	NN	Number=Sing	_	_	_	_
23	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
24	suggested	suggest	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
25	recently	recently	ADV	RB	_	_	_	_	SpaceAfter=No
26	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2357
# text = Salicylates have been shown to inhibit lipopolysaccharide-induced gene transcription via inhibition of NF-kappa B activation by preventing the degradation of NF-kappa B inhibitor "I kappa B", blocking the translocation of NF-kappa B into the nuclear compartment.
1	Salicylates	Salicylate	NOUN	NNS	Number=Plur	_	_	_	_
2	have	have	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
3	been	be	AUX	VBN	Tense=Past|VerbForm=Part	_	_	_	_
4	shown	show	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
5	to	to	PART	TO	_	_	_	_	_
6	inhibit	inhibit	VERB	VB	VerbForm=Inf	_	_	_	_
7	lipopolysaccharide	lipopolysaccharide	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
8	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
9	induced	induce	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
10	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
11	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
12	via	via	ADP	IN	_	_	_	_	_
13	inhibition	inhibition	NOUN	NN	Number=Sing	_	_	_	_
14	of	of	ADP	IN	_	_	_	_	_
15	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
16	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
17	kappa	kappa	PROPN	NNP	Number=Sing	_	_	_	_
18	B	b	PROPN	NNP	Number=Sing	_	_	_	_
19	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
20	by	by	SCONJ	IN	_	_	_	_	_
21	preventing	prevent	VERB	VBG	VerbForm=Ger	_	_	_	_
22	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
23	degradation	degradation	NOUN	NN	Number=Sing	_	_	_	_
24	of	of	ADP	IN	_	_	_	_	_
25	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
26	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
27	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_
28	B	b	NOUN	NN	Number=Sing	_	_	_	_
29	inhibitor	inhibitor	NOUN	NN	Number=Sing	_	_	_	_
30	"	"	PUNCT	''	_	_	_	_	SpaceAfter=No
31	I	I	PRON	PRP	Case=Nom|Number=Sing|Person=1|PronType=Prs	_	_	_	_
32	kappa	kappa	PROPN	NNP	Number=Sing	_	_	_	_
33	B	B	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
34	"	"	PUNCT	''	_	_	_	_	SpaceAfter=No
35	,	,	PUNCT	,	_	_	_	_	_
36	blocking	block	VERB	VBG	VerbForm=Ger	_	_	_	_
37	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
38	translocation	translocation	NOUN	NN	Number=Sing	_	_	_	_
39	of	of	ADP	IN	_	_	_	_	_
40	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
41	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
42	kappa	kappa	PROPN	NNP	Number=Sing	_	_	_	_
43	B	b	PROPN	NNP	Number=Sing	_	_	_	_
44	into	into	ADP	IN	_	_	_	_	_
45	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
46	nuclear	nuclear	ADJ	JJ	Degree=Pos	_	_	_	_
47	compartment	compartment	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
48	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2358
# text = However, the nature of the subunit involved in this mechanism has not been defined.
1	However	however	ADV	RB	_	_	_	_	SpaceAfter=No
2	,	,	PUNCT	,	_	_	_	_	_
3	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
4	nature	nature	NOUN	NN	Number=Sing	_	_	_	_
5	of	of	ADP	IN	_	_	_	_	_
6	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
7	subunit	subunit	NOUN	NN	Number=Sing	_	_	_	_
8	involved	involve	ADJ	JJ	Degree=Pos	_	_	_	_
9	in	in	ADP	IN	_	_	_	_	_
10	this	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
11	mechanism	mechanism	NOUN	NN	Number=Sing	_	_	_	_
12	has	have	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
13	not	not	PART	RB	_	_	_	_	_
14	been	be	AUX	VBN	Tense=Past|VerbForm=Part	_	_	_	_
15	defined	define	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	SpaceAfter=No
16	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2359
# text = To examine the mechanisms by which salicylates affect cytokine gene transcription, the amount of active and inactive NF-kappa B and NF-kappa B mRNA, in Porphyromonas gingivalis lipopolysaccharide-stimulated human monocytic cells was assessed.
1	To	to	PART	TO	_	_	_	_	_
2	examine	examine	VERB	VB	VerbForm=Inf	_	_	_	_
3	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
4	mechanisms	mechanism	NOUN	NNS	Number=Plur	_	_	_	_
5	by	by	ADP	IN	_	_	_	_	_
6	which	which	PRON	WDT	PronType=Rel	_	_	_	_
7	salicylates	salicylate	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
8	affect	affect	ADJ	JJ	Degree=Pos	_	_	_	_
9	cytokine	cytokine	NOUN	NN	Number=Sing	_	_	_	_
10	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
11	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
12	,	,	PUNCT	,	_	_	_	_	_
13	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
14	amount	amount	NOUN	NN	Number=Sing	_	_	_	_
15	of	of	ADP	IN	_	_	_	_	_
16	active	active	ADJ	JJ	Degree=Pos	_	_	_	_
17	and	and	CCONJ	CC	_	_	_	_	_
18	inactive	inactive	ADJ	JJ	Degree=Pos	_	_	_	_
19	NF	Nf	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
20	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
21	kappa	kappa	PROPN	NNP	Number=Sing	_	_	_	_
22	B	b	PROPN	NNP	Number=Sing	_	_	_	_
23	and	and	CCONJ	CC	_	_	_	_	_
24	NF	Nf	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
25	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
26	kappa	kappa	PROPN	NNP	Number=Sing	_	_	_	_
27	B	b	PROPN	NNP	Number=Sing	_	_	_	_
28	mRNA	mRNA	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
29	,	,	PUNCT	,	_	_	_	_	_
30	in	in	ADP	IN	_	_	_	_	_
31	Porphyromonas	Porphyromonas	PROPN	NNP	Number=Sing	_	_	_	_
32	gingivalis	gingivalis	PROPN	NNP	Number=Sing	_	_	_	_
33	lipopolysaccharide-stimulated	lipopolysaccharide-stimulate	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
34	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
35	monocytic	monocytic	ADJ	JJ	Degree=Pos	_	_	_	_
36	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
37	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
38	assessed	assess	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	SpaceAfter=No
39	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2360
# text = High doses of sodium salicylate suppressed NF-kappa B p65 mRNA accumulation, resulting in suppression of total NF-kappa B, p50 on tissue oligonucleotide had no effects on lipopolysaccharide-induced NF-kappa B activation.
1	High	high	ADJ	JJ	Degree=Pos	_	_	_	_
2	doses	dos	NOUN	NNS	Number=Plur	_	_	_	_
3	of	of	ADP	IN	_	_	_	_	_
4	sodium	sodium	NOUN	NN	Number=Sing	_	_	_	_
5	salicylate	salicylate	NOUN	NN	Number=Sing	_	_	_	_
6	suppressed	suppress	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
7	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
8	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
9	kappa	kappa	PROPN	NNP	Number=Sing	_	_	_	_
10	B	b	PROPN	NNP	Number=Sing	_	_	_	_
11	p65	p65	NUM	CD	NumType=Card	_	_	_	_
12	mRNA	mRNA	PROPN	NNP	Number=Sing	_	_	_	_
13	accumulation	accumulation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
14	,	,	PUNCT	,	_	_	_	_	_
15	resulting	result	VERB	VBG	VerbForm=Ger	_	_	_	_
16	in	in	ADP	IN	_	_	_	_	_
17	suppression	suppression	NOUN	NN	Number=Sing	_	_	_	_
18	of	of	ADP	IN	_	_	_	_	_
19	total	total	ADJ	JJ	Degree=Pos	_	_	_	_
20	NF	NF	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
21	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
22	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_
23	B	b	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
24	,	,	PUNCT	,	_	_	_	_	_
25	p50	p50	NUM	CD	NumType=Card	_	_	_	_
26	on	on	ADP	IN	_	_	_	_	_
27	tissue	tissue	NOUN	NN	Number=Sing	_	_	_	_
28	oligonucleotide	oligonucleotide	ADV	RB	_	_	_	_	_
29	had	have	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
30	no	no	DET	DT	_	_	_	_	_
31	effects	effect	NOUN	NNS	Number=Plur	_	_	_	_
32	on	on	ADP	IN	_	_	_	_	_
33	lipopolysaccharide	lipopolysaccharide	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
34	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
35	induced	induce	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
36	NF	Nf	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
37	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
38	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_
39	B	b	NOUN	NN	Number=Sing	_	_	_	_
40	activation	activation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
41	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2361
# text = The data demonstrate that the p65 subunit of NF-kappa B is inhibited by salicylate treatment and highlight the role of salicylate in the control of gene expression of inflammatory mediators.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	data	data	NOUN	NN	Number=Sing	_	_	_	_
3	demonstrate	demonstrate	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
4	that	that	SCONJ	IN	_	_	_	_	_
5	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
6	p65	p65	NOUN	NN	Number=Sing	_	_	_	_
7	subunit	subunit	NOUN	NN	Number=Sing	_	_	_	_
8	of	of	ADP	IN	_	_	_	_	_
9	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
10	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
11	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_
12	B	b	NOUN	NN	Number=Sing	_	_	_	_
13	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
14	inhibited	inhibit	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
15	by	by	ADP	IN	_	_	_	_	_
16	salicylate	salicylate	ADJ	JJ	Degree=Pos	_	_	_	_
17	treatment	treatment	NOUN	NN	Number=Sing	_	_	_	_
18	and	and	CCONJ	CC	_	_	_	_	_
19	highlight	highlight	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
20	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
21	role	role	NOUN	NN	Number=Sing	_	_	_	_
22	of	of	ADP	IN	_	_	_	_	_
23	salicylate	salicylate	NOUN	NN	Number=Sing	_	_	_	_
24	in	in	ADP	IN	_	_	_	_	_
25	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
26	control	control	NOUN	NN	Number=Sing	_	_	_	_
27	of	of	ADP	IN	_	_	_	_	_
28	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
29	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
30	of	of	ADP	IN	_	_	_	_	_
31	inflammatory	inflammatory	ADJ	JJ	Degree=Pos	_	_	_	_
32	mediators	mediator	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
33	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 2362
# text = Document 003003205 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	003003205	003003205	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 2363
# text = ICSAT overexpression is not sufficient to cause adult T-cell leukemia or multiple myeloma.
1	ICSAT	Icsat	NOUN	NN	Number=Sing	_	_	_	_
2	overexpression	overexpression	NOUN	NN	Number=Sing	_	_	_	_
3	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
4	not	not	PART	RB	_	_	_	_	_
5	sufficient	sufficient	ADJ	JJ	Degree=Pos	_	_	_	_
6	to	to	PART	TO	_	_	_	_	_
7	cause	cause	VERB	VB	VerbForm=Inf	_	_	_	_
8	adult	adult	NOUN	NN	Number=Sing	_	_	_	_
9	T-	t-	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
10	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
11	leukemia	leukemia	NOUN	NN	Number=Sing	_	_	_	_
12	or	or	CCONJ	CC	_	_	_	_	_
13	multiple	multiple	ADJ	JJ	Degree=Pos	_	_	_	_
14	myeloma	myeloma	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
15	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 2364
# text = ICSAT (Interferon Consensus Sequence binding protein for Activated T cells) is a lymphocyte-specific member of the interferon regulatory factor (IRF) family of transcription factors, originally identified through Southwestern screening of the ATL(Adult T-cell leukemia)-16T expression library.
1	ICSAT	ICSAT	PROPN	NNP	Number=Sing	_	_	_	_
2	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
3	Interferon	Interferon	PROPN	NNP	Number=Sing	_	_	_	_
4	Consensus	consensus	PROPN	NNP	Number=Sing	_	_	_	_
5	Sequence	Sequence	PROPN	NNP	Number=Sing	_	_	_	_
6	binding	bind	VERB	VBG	VerbForm=Ger	_	_	_	_
7	protein	protein	NOUN	NN	Number=Sing	_	_	_	_
8	for	for	ADP	IN	_	_	_	_	_
9	Activated	activate	PROPN	NNP	Number=Sing	_	_	_	_
10	T	t	PROPN	NNP	Number=Sing	_	_	_	_
11	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
12	)	)	PUNCT	-RRB-	_	_	_	_	_
13	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
14	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
15	lymphocyte	lymphocyte	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
16	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
17	specific	specific	ADJ	JJ	Degree=Pos	_	_	_	_
18	member	member	NOUN	NN	Number=Sing	_	_	_	_
19	of	of	ADP	IN	_	_	_	_	_
20	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
21	interferon	interferon	ADJ	JJ	Degree=Pos	_	_	_	_
22	regulatory	regulatory	ADJ	JJ	Degree=Pos	_	_	_	_
23	factor	factor	NOUN	NN	Number=Sing	_	_	_	_
24	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
25	IRF	IRF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
26	)	)	PUNCT	-RRB-	_	_	_	_	_
27	family	family	NOUN	NN	Number=Sing	_	_	_	_
28	of	of	ADP	IN	_	_	_	_	_
29	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
30	factors	factor	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
31	,	,	PUNCT	,	_	_	_	_	_
32	originally	originally	ADV	RB	_	_	_	_	_
33	identified	identify	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
34	through	through	ADP	IN	_	_	_	_	_
35	Southwestern	southwestern	ADJ	JJ	Degree=Pos	_	_	_	_
36	screening	screening	NOUN	NN	Number=Sing	_	_	_	_
37	of	of	ADP	IN	_	_	_	_	_
38	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
39	ATL	ATL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
40	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
41	Adult	adult	PROPN	NNP	Number=Sing	_	_	_	_
42	T-	t-	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
43	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
44	leukemia	leukemia	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
45	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
46	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
47	16T	16t	ADJ	JJ	Degree=Pos	_	_	_	_
48	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
49	library	library	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
50	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2365
# text = In this study, we created transgenic mice overexpressing ICSAT in lymphocytes.
1	In	in	ADP	IN	_	_	_	_	_
2	this	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
3	study	study	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
4	,	,	PUNCT	,	_	_	_	_	_
5	we	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
6	created	create	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
7	transgenic	transgenic	ADJ	JJ	Degree=Pos	_	_	_	_
8	mice	mouse	NOUN	NNS	Number=Plur	_	_	_	_
9	overexpressing	overexpresse	VERB	VBG	VerbForm=Ger	_	_	_	_
10	ICSAT	Icsat	PRON	WP	PronType=Int	_	_	_	_
11	in	in	ADP	IN	_	_	_	_	_
12	lymphocytes	lymphocyte	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
13	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2366
# text = Although spontaneous tumorigenesis was not observed, IL-2 production with Concanavalin A stimulation was significantly increased in transgenic mice overexpressing ICSAT.
1	Although	although	SCONJ	IN	_	_	_	_	_
2	spontaneous	spontaneous	ADJ	JJ	Degree=Pos	_	_	_	_
3	tumorigenesis	tumorigenesis	NOUN	NN	Number=Sing	_	_	_	_
4	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
5	not	not	PART	RB	_	_	_	_	_
6	observed	observe	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	SpaceAfter=No
7	,	,	PUNCT	,	_	_	_	_	_
8	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
9	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
10	2	2	NUM	CD	NumType=Card	_	_	_	_
11	production	production	NOUN	NN	Number=Sing	_	_	_	_
12	with	with	ADP	IN	_	_	_	_	_
13	Concanavalin	Concanavalin	PROPN	NNP	Number=Sing	_	_	_	_
14	A	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
15	stimulation	stimulation	NOUN	NN	Number=Sing	_	_	_	_
16	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
17	significantly	significantly	ADV	RB	_	_	_	_	_
18	increased	increase	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
19	in	in	ADP	IN	_	_	_	_	_
20	transgenic	transgenic	ADJ	JJ	Degree=Pos	_	_	_	_
21	mice	mouse	NOUN	NNS	Number=Plur	_	_	_	_
22	overexpressing	overexpresse	VERB	VBG	VerbForm=Ger	_	_	_	_
23	ICSAT	ICSAT	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
24	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2367
# text = ICSAT overexpression in lymphocytes seems insufficient for the leukemogenesis of ATL or multiple myeloma (MM), however, it may regulate T cell activation and its overexpression may lead to leukemogenesis via controlling IL-2 production.
1	ICSAT	Icsit	ADJ	JJ	Degree=Pos	_	_	_	_
2	overexpression	overexpression	NOUN	NN	Number=Sing	_	_	_	_
3	in	in	ADP	IN	_	_	_	_	_
4	lymphocytes	lymphocyte	NOUN	NNS	Number=Plur	_	_	_	_
5	seems	seem	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
6	insufficient	insufficient	ADJ	JJ	Degree=Pos	_	_	_	_
7	for	for	ADP	IN	_	_	_	_	_
8	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
9	leukemogenesis	leukemogenesis	NOUN	NN	Number=Sing	_	_	_	_
10	of	of	ADP	IN	_	_	_	_	_
11	ATL	ATL	PROPN	NNP	Number=Sing	_	_	_	_
12	or	or	CCONJ	CC	_	_	_	_	_
13	multiple	multiple	ADJ	JJ	Degree=Pos	_	_	_	_
14	myeloma	myeloma	NOUN	NN	Number=Sing	_	_	_	_
15	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
16	MM	mm	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
17	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
18	,	,	PUNCT	,	_	_	_	_	_
19	however	however	ADV	RB	_	_	_	_	SpaceAfter=No
20	,	,	PUNCT	,	_	_	_	_	_
21	it	it	PRON	PRP	Case=Nom|Gender=Neut|Number=Sing|Person=3|PronType=Prs	_	_	_	_
22	may	may	AUX	MD	VerbForm=Fin	_	_	_	_
23	regulate	regulate	VERB	VB	VerbForm=Inf	_	_	_	_
24	T	t	PROPN	NNP	Number=Sing	_	_	_	_
25	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
26	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
27	and	and	CCONJ	CC	_	_	_	_	_
28	its	its	PRON	PRP$	Gender=Neut|Number=Sing|Person=3|Poss=Yes|PronType=Prs	_	_	_	_
29	overexpression	overexpression	NOUN	NN	Number=Sing	_	_	_	_
30	may	may	AUX	MD	VerbForm=Fin	_	_	_	_
31	lead	lead	VERB	VB	VerbForm=Inf	_	_	_	_
32	to	to	ADP	IN	_	_	_	_	_
33	leukemogenesis	leukemogenesis	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
34	via	via	NOUN	NN	Number=Sing	_	_	_	_
35	controlling	controlle	VERB	VBG	VerbForm=Ger	_	_	_	_
36	IL	Il	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
37	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
38	2	2	NUM	CD	NumType=Card	_	_	_	_
39	production	production	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
40	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2368
# text = Copyright 1999 Academic Press.
1	Copyright	copyright	NOUN	NN	Number=Sing	_	_	_	_
2	1999	1999	NUM	CD	NumType=Card	_	_	_	_
3	Academic	academic	PROPN	NNP	Number=Sing	_	_	_	_
4	Press.	Press.	PROPN	NNP	Number=Sing	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 2369
# text = Document 003003208 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	003003208	003003208	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 2370
# text = The DNA and steroid binding domains of the glucocorticoid receptor are not altered in mononuclear cells of treated CLL patients.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	DNA	dna	NOUN	NN	Number=Sing	_	_	_	_
3	and	and	CCONJ	CC	_	_	_	_	_
4	steroid	steroid	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
5	binding	bind	VERB	VBG	VerbForm=Ger	_	_	_	_
6	domains	domain	NOUN	NNS	Number=Plur	_	_	_	_
7	of	of	ADP	IN	_	_	_	_	_
8	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
9	glucocorticoid	glucocorticoid	ADJ	JJ	Degree=Pos	_	_	_	_
10	receptor	receptor	NOUN	NN	Number=Sing	_	_	_	_
11	are	be	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
12	not	not	PART	RB	_	_	_	_	_
13	altered	alter	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
14	in	in	ADP	IN	_	_	_	_	_
15	mononuclear	mononuclear	ADJ	JJ	Degree=Pos	_	_	_	_
16	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
17	of	of	ADP	IN	_	_	_	_	_
18	treated	treat	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
19	CLL	Cll	NOUN	NN	Number=Sing	_	_	_	_
20	patients	patient	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
21	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 2371
# text = The aim of this study was to investigate whether mutations in the glucocorticoid receptor could account for the increasing unresponsiveness of patients with chronic lymphatic leukemia (CLL) to combination chemotherapy.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	aim	aim	NOUN	NN	Number=Sing	_	_	_	_
3	of	of	ADP	IN	_	_	_	_	_
4	this	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
5	study	study	NOUN	NN	Number=Sing	_	_	_	_
6	was	be	VERB	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
7	to	to	PART	TO	_	_	_	_	_
8	investigate	investigate	VERB	VB	VerbForm=Inf	_	_	_	_
9	whether	whether	SCONJ	IN	_	_	_	_	_
10	mutations	mutation	NOUN	NNS	Number=Plur	_	_	_	_
11	in	in	ADP	IN	_	_	_	_	_
12	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
13	glucocorticoid	glucocorticoid	ADJ	JJ	Degree=Pos	_	_	_	_
14	receptor	receptor	NOUN	NN	Number=Sing	_	_	_	_
15	could	could	AUX	MD	VerbForm=Fin	_	_	_	_
16	account	account	VERB	VB	VerbForm=Inf	_	_	_	_
17	for	for	ADP	IN	_	_	_	_	_
18	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
19	increasing	increase	VERB	VBG	VerbForm=Ger	_	_	_	_
20	unresponsiveness	unresponsiveness	NOUN	NN	Number=Sing	_	_	_	_
21	of	of	ADP	IN	_	_	_	_	_
22	patients	patient	NOUN	NNS	Number=Plur	_	_	_	_
23	with	with	ADP	IN	_	_	_	_	_
24	chronic	chronic	ADJ	JJ	Degree=Pos	_	_	_	_
25	lymphatic	lymphatic	ADJ	JJ	Degree=Pos	_	_	_	_
26	leukemia	leukemia	NOUN	NN	Number=Sing	_	_	_	_
27	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
28	CLL	CLL	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
29	)	)	PUNCT	-RRB-	_	_	_	_	_
30	to	to	ADP	IN	_	_	_	_	_
31	combination	combination	NOUN	NN	Number=Sing	_	_	_	_
32	chemotherapy	chemotherapy	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
33	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2372
# text = The receptor was tested immunocytochemically, in steroid binding assays, and by a mutation screening (denaturing gradient gel electrophoresis) of the receptor-cDNA.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	receptor	receptor	NOUN	NN	Number=Sing	_	_	_	_
3	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
4	tested	test	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
5	immunocytochemically	immunocytochemically	ADV	RB	_	_	_	_	SpaceAfter=No
6	,	,	PUNCT	,	_	_	_	_	_
7	in	in	ADP	IN	_	_	_	_	_
8	steroid	steroid	ADJ	JJ	Degree=Pos	_	_	_	_
9	binding	binding	VERB	VBG	VerbForm=Ger	_	_	_	_
10	assays	assay	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
11	,	,	PUNCT	,	_	_	_	_	_
12	and	and	CCONJ	CC	_	_	_	_	_
13	by	by	ADP	IN	_	_	_	_	_
14	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
15	mutation	mutation	NOUN	NN	Number=Sing	_	_	_	_
16	screening	screening	NOUN	NN	Number=Sing	_	_	_	_
17	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
18	denaturing	denatur	VERB	VBG	VerbForm=Ger	_	_	_	_
19	gradient	gradient	ADJ	JJ	Degree=Pos	_	_	_	_
20	gel	gel	NOUN	NN	Number=Sing	_	_	_	_
21	electrophoresis	electrophoresis	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	SpaceAfter=No
22	)	)	PUNCT	-RRB-	_	_	_	_	_
23	of	of	ADP	IN	_	_	_	_	_
24	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
25	receptor-cDNA	receptor-cDNa	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
26	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2373
# text = The receptor concentration, as measured by staining and steroid binding test, varied considerably but showed no clear correlation to clinical response.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	receptor	receptor	NOUN	NN	Number=Sing	_	_	_	_
3	concentration	concentration	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
4	,	,	PUNCT	,	_	_	_	_	_
5	as	as	SCONJ	IN	_	_	_	_	_
6	measured	measure	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
7	by	by	SCONJ	IN	_	_	_	_	_
8	staining	staining	VERB	VBG	VerbForm=Ger	_	_	_	_
9	and	and	CCONJ	CC	_	_	_	_	_
10	steroid	steroid	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
11	binding	binding	VERB	VBG	VerbForm=Ger	_	_	_	_
12	test	test	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
13	,	,	PUNCT	,	_	_	_	_	_
14	varied	vary	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
15	considerably	considerably	ADV	RB	_	_	_	_	_
16	but	but	CCONJ	CC	_	_	_	_	_
17	showed	show	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
18	no	no	DET	DT	_	_	_	_	_
19	clear	clear	ADJ	JJ	Degree=Pos	_	_	_	_
20	correlation	correlation	NOUN	NN	Number=Sing	_	_	_	_
21	to	to	ADP	IN	_	_	_	_	_
22	clinical	clinical	ADJ	JJ	Degree=Pos	_	_	_	_
23	response	response	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
24	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2374
# text = Using a highly sensitive mutation screening assay of the DNA- and the steroid-binding region, none of the treated patients revealed any mutation, suggesting that the glucocorticoid receptor in the CLL patients tested is not altered in these domains.
1	Using	use	VERB	VBG	VerbForm=Ger	_	_	_	_
2	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
3	highly	highly	ADV	RB	_	_	_	_	_
4	sensitive	sensitive	ADJ	JJ	Degree=Pos	_	_	_	_
5	mutation	mutation	NOUN	NN	Number=Sing	_	_	_	_
6	screening	screen	NOUN	NN	Number=Sing	_	_	_	_
7	assay	assay	NOUN	NN	Number=Sing	_	_	_	_
8	of	of	ADP	IN	_	_	_	_	_
9	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
10	DNA	dna	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
11	-	-	PUNCT	,	_	_	_	_	_
12	and	and	CCONJ	CC	_	_	_	_	_
13	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
14	steroid	steroid	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
15	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
16	binding	binde	VERB	VBG	VerbForm=Ger	_	_	_	_
17	region	region	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
18	,	,	PUNCT	,	_	_	_	_	_
19	none	none	NOUN	NN	Number=Sing	_	_	_	_
20	of	of	ADP	IN	_	_	_	_	_
21	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
22	treated	treat	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
23	patients	patient	NOUN	NNS	Number=Plur	_	_	_	_
24	revealed	reveal	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
25	any	any	DET	DT	_	_	_	_	_
26	mutation	mutation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
27	,	,	PUNCT	,	_	_	_	_	_
28	suggesting	suggest	VERB	VBG	VerbForm=Ger	_	_	_	_
29	that	that	SCONJ	IN	_	_	_	_	_
30	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
31	glucocorticoid	glucocorticoid	ADJ	JJ	Degree=Pos	_	_	_	_
32	receptor	receptor	NOUN	NN	Number=Sing	_	_	_	_
33	in	in	ADP	IN	_	_	_	_	_
34	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
35	CLL	CLL	PROPN	NNP	Number=Sing	_	_	_	_
36	patients	patient	NOUN	NN	Number=Sing	_	_	_	_
37	tested	test	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
38	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
39	not	not	PART	RB	_	_	_	_	_
40	altered	alter	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
41	in	in	ADP	IN	_	_	_	_	_
42	these	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
43	domains	domains	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
44	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2375
# text = In one individual who had not been treated before analysis a silent mutation was found in one receptor allele.
1	In	in	ADP	IN	_	_	_	_	_
2	one	one	NUM	CD	NumType=Card	_	_	_	_
3	individual	individual	ADJ	JJ	Degree=Pos	_	_	_	_
4	who	who	PRON	WP	PronType=Rel	_	_	_	_
5	had	have	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
6	not	not	PART	RB	_	_	_	_	_
7	been	be	AUX	VBN	Tense=Past|VerbForm=Part	_	_	_	_
8	treated	treat	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
9	before	before	ADP	IN	_	_	_	_	_
10	analysis	analysis	NOUN	NN	Number=Sing	_	_	_	_
11	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
12	silent	silent	ADJ	JJ	Degree=Pos	_	_	_	_
13	mutation	mutation	NOUN	NN	Number=Sing	_	_	_	_
14	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
15	found	find	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
16	in	in	ADP	IN	_	_	_	_	_
17	one	one	NUM	CD	NumType=Card	_	_	_	_
18	receptor	receptor	NOUN	NN	Number=Sing	_	_	_	_
19	allele	allele	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
20	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2376
# text = The results suggest that mechanisms other than altered ligand or DNA binding of the receptor may be responsible for the lack of response to chemotherapy.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	results	result	NOUN	NNS	Number=Plur	_	_	_	_
3	suggest	suggest	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
4	that	that	SCONJ	IN	_	_	_	_	_
5	mechanisms	mechanism	NOUN	NNS	Number=Plur	_	_	_	_
6	other	other	ADJ	JJ	Degree=Pos	_	_	_	_
7	than	than	ADP	IN	_	_	_	_	_
8	altered	alter	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
9	ligand	ligand	NOUN	NN	Number=Sing	_	_	_	_
10	or	or	CCONJ	CC	_	_	_	_	_
11	DNA	dna	NOUN	NN	Number=Sing	_	_	_	_
12	binding	binding	VERB	VBG	VerbForm=Ger	_	_	_	_
13	of	of	ADP	IN	_	_	_	_	_
14	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
15	receptor	receptor	NOUN	NN	Number=Sing	_	_	_	_
16	may	may	AUX	MD	VerbForm=Fin	_	_	_	_
17	be	be	AUX	VB	VerbForm=Inf	_	_	_	_
18	responsible	responsible	ADJ	JJ	Degree=Pos	_	_	_	_
19	for	for	ADP	IN	_	_	_	_	_
20	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
21	lack	lack	NOUN	NN	Number=Sing	_	_	_	_
22	of	of	ADP	IN	_	_	_	_	_
23	response	response	NOUN	NN	Number=Sing	_	_	_	_
24	to	to	ADP	IN	_	_	_	_	_
25	chemotherapy	chemotherapy	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
26	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2377
# text = This conclusion is discussed in relation to the mechanism of corticoid resistance in mouse and human lymphoma cells in culture.
1	This	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
2	conclusion	conclusion	NOUN	NN	Number=Sing	_	_	_	_
3	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
4	discussed	discuss	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
5	in	in	ADP	IN	_	_	_	_	_
6	relation	relation	NOUN	NN	Number=Sing	_	_	_	_
7	to	to	ADP	IN	_	_	_	_	_
8	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
9	mechanism	mechanism	NOUN	NN	Number=Sing	_	_	_	_
10	of	of	ADP	IN	_	_	_	_	_
11	corticoid	corticoid	ADJ	JJ	Degree=Pos	_	_	_	_
12	resistance	resistance	NOUN	NN	Number=Sing	_	_	_	_
13	in	in	ADP	IN	_	_	_	_	_
14	mouse	mouse	NOUN	NN	Number=Sing	_	_	_	_
15	and	and	CCONJ	CC	_	_	_	_	_
16	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
17	lymphoma	lymphoma	NOUN	NN	Number=Sing	_	_	_	_
18	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
19	in	in	ADP	IN	_	_	_	_	_
20	culture	culture	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
21	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 2378
# text = Document 003003211 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	003003211	003003211	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 2379
# text = Block of granulocytic differentiation of 32Dcl3 cells by AML1/ETO(MTG8) but not by highly expressed Bcl-2.
1	Block	block	NOUN	NN	Number=Sing	_	_	_	_
2	of	of	ADP	IN	_	_	_	_	_
3	granulocytic	granulocytic	ADJ	JJ	Degree=Pos	_	_	_	_
4	differentiation	differentiation	NOUN	NN	Number=Sing	_	_	_	_
5	of	of	ADP	IN	_	_	_	_	_
6	32	32	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
7	Dcl3	Dcl3	NUM	CD	NumType=Card	_	_	_	_
8	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
9	by	by	ADP	IN	_	_	_	_	_
10	AML1/	Aml1/	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
11	ETO	ETO	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
12	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
13	MTG8	MTG8	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
14	)	)	PUNCT	-RRB-	_	_	_	_	_
15	but	but	CCONJ	CC	_	_	_	_	_
16	not	not	ADV	RB	_	_	_	_	_
17	by	by	ADP	IN	_	_	_	_	_
18	highly	highly	ADV	RB	_	_	_	_	_
19	expressed	express	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
20	Bcl	Bcl	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
21	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
22	2	2	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
23	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 2380
# text = The chimeric gene, AML1/ETO (MTG8), generated in t(8;21) acute myeloid leukemia enhances the expression of Bcl-2.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	chimeric	chimeric	ADJ	JJ	Degree=Pos	_	_	_	_
3	gene	gene	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
4	,	,	PUNCT	,	_	_	_	_	_
5	AML1/	Aml1/	ADP	IN	Abbr=Yes	_	_	_	SpaceAfter=No
6	ETO	ETO	PROPN	NNP	Number=Sing	_	_	_	_
7	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
8	MTG8	MTG8	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
9	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
10	,	,	PUNCT	,	_	_	_	_	_
11	generated	generate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
12	in	in	ADP	IN	_	_	_	_	_
13	t	t	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
14	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
15	8;21	8;21	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
16	)	)	PUNCT	-RRB-	_	_	_	_	_
17	acute	acute	NOUN	NN	Number=Sing	_	_	_	_
18	myeloid	myeloid	NOUN	NN	Number=Sing	_	_	_	_
19	leukemia	leukemia	NOUN	NN	Number=Sing	_	_	_	_
20	enhances	enhance	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
21	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
22	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
23	of	of	ADP	IN	_	_	_	_	_
24	Bcl	Bcl	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
25	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
26	2	2	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
27	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2381
# text = To evaluate whether this enhancement is the primary role of AML1/ETO in leukemogenesis, effects of over-expression of Bcl-2 in the murine myeloid precursor cell line, 32Dcl3, were examined.
1	To	to	PART	TO	_	_	_	_	_
2	evaluate	evaluate	VERB	VB	VerbForm=Inf	_	_	_	_
3	whether	whether	SCONJ	IN	_	_	_	_	_
4	this	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
5	enhancement	enhancement	NOUN	NN	Number=Sing	_	_	_	_
6	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
7	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
8	primary	primary	ADJ	JJ	Degree=Pos	_	_	_	_
9	role	role	NOUN	NN	Number=Sing	_	_	_	_
10	of	of	ADP	IN	_	_	_	_	_
11	AML1/	Aml1/	ADP	IN	Abbr=Yes	_	_	_	SpaceAfter=No
12	ETO	Eto	PROPN	NNP	Number=Sing	_	_	_	_
13	in	in	ADP	IN	_	_	_	_	_
14	leukemogenesis	leukemogenesis	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
15	,	,	PUNCT	,	_	_	_	_	_
16	effects	effect	NOUN	NNS	Number=Plur	_	_	_	_
17	of	of	ADP	IN	_	_	_	_	_
18	over-expression	over-expression	NOUN	NN	Number=Sing	_	_	_	_
19	of	of	ADP	IN	_	_	_	_	_
20	Bcl	Bcl	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
21	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
22	2	2	NUM	CD	NumType=Card	_	_	_	_
23	in	in	ADP	IN	_	_	_	_	_
24	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
25	murine	murine	NOUN	NN	Number=Sing	_	_	_	_
26	myeloid	myeloid	NOUN	NN	Number=Sing	_	_	_	_
27	precursor	precursor	NOUN	NN	Number=Sing	_	_	_	_
28	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
29	line	line	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
30	,	,	PUNCT	,	_	_	_	_	_
31	32Dcl3	32Dcl3	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
32	,	,	PUNCT	,	_	_	_	_	_
33	were	be	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
34	examined	examin	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	SpaceAfter=No
35	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2382
# text = When 32Dcl3 cells expressing exogenous Bcl-2 were induced to differentiate, the onset of morphological differentiation was delayed.
1	When	when	ADV	WRB	PronType=Int	_	_	_	_
2	32	32	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
3	Dcl3	Dcl3	NUM	CD	NumType=Card	_	_	_	_
4	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
5	expressing	express	VERB	VBG	VerbForm=Ger	_	_	_	_
6	exogenous	exogenous	ADJ	JJ	Degree=Pos	_	_	_	_
7	Bcl	Bcl	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
8	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
9	2	2	NUM	CD	NumType=Card	_	_	_	_
10	were	be	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
11	induced	induce	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
12	to	to	PART	TO	_	_	_	_	_
13	differentiate	differentiate	VERB	VB	VerbForm=Inf	_	_	_	SpaceAfter=No
14	,	,	PUNCT	,	_	_	_	_	_
15	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
16	onset	onset	NOUN	NN	Number=Sing	_	_	_	_
17	of	of	ADP	IN	_	_	_	_	_
18	morphological	morphological	ADJ	JJ	Degree=Pos	_	_	_	_
19	differentiation	differentiation	NOUN	NN	Number=Sing	_	_	_	_
20	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
21	delayed	delay	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
22	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2383
# text = However, even the cells expressing very high levels of exogenous Bcl-2 eventually underwent differentiation without a significant decrease in the synthesis of Bcl-2.
1	However	however	ADV	RB	_	_	_	_	SpaceAfter=No
2	,	,	PUNCT	,	_	_	_	_	_
3	even	even	ADV	RB	_	_	_	_	_
4	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
5	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
6	expressing	express	VERB	VBG	VerbForm=Ger	_	_	_	_
7	very	very	ADV	RB	_	_	_	_	_
8	high	high	ADJ	JJ	Degree=Pos	_	_	_	_
9	levels	level	NOUN	NNS	Number=Plur	_	_	_	_
10	of	of	ADP	IN	_	_	_	_	_
11	exogenous	exogenous	ADJ	JJ	Degree=Pos	_	_	_	_
12	Bcl	Bcl	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
13	-2	-2	NUM	CD	NumType=Card	_	_	_	_
14	eventually	eventually	ADV	RB	_	_	_	_	_
15	underwent	underwent	ADJ	JJ	Degree=Pos	_	_	_	_
16	differentiation	differentiation	NOUN	NN	Number=Sing	_	_	_	_
17	without	without	ADP	IN	_	_	_	_	_
18	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
19	significant	significant	ADJ	JJ	Degree=Pos	_	_	_	_
20	decrease	decrease	NOUN	NN	Number=Sing	_	_	_	_
21	in	in	ADP	IN	_	_	_	_	_
22	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
23	synthesis	synthesis	NOUN	NN	Number=Sing	_	_	_	_
24	of	of	ADP	IN	_	_	_	_	_
25	Bcl	Bcl	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
26	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
27	2	2	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
28	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2384
# text = On the contrary, 32Dcl3 cells stably expressing AML1/ETO were completely resistant to differentiation and continued to grow in the presence of G-CSF.
1	On	on	ADP	IN	_	_	_	_	_
2	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
3	contrary	contrary	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
4	,	,	PUNCT	,	_	_	_	_	_
5	32	32	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
6	Dcl3	Dcl3	NUM	CD	NumType=Card	_	_	_	_
7	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
8	stably	stably	ADV	RB	_	_	_	_	_
9	expressing	express	VERB	VBG	VerbForm=Ger	_	_	_	_
10	AML1/	AML1ith	ADP	IN	Abbr=Yes	_	_	_	SpaceAfter=No
11	ETO	ETO	PROPN	NNP	Number=Sing	_	_	_	_
12	were	be	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
13	completely	completely	ADV	RB	_	_	_	_	_
14	resistant	resistant	ADJ	JJ	Degree=Pos	_	_	_	_
15	to	to	ADP	IN	_	_	_	_	_
16	differentiation	differentiation	NOUN	NN	Number=Sing	_	_	_	_
17	and	and	CCONJ	CC	_	_	_	_	_
18	continued	continue	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
19	to	to	PART	TO	_	_	_	_	_
20	grow	grow	VERB	VB	VerbForm=Inf	_	_	_	_
21	in	in	ADP	IN	_	_	_	_	_
22	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
23	presence	presence	NOUN	NN	Number=Sing	_	_	_	_
24	of	of	ADP	IN	_	_	_	_	_
25	G-	g-	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
26	CSF	CSF	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
27	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2385
# text = These results are consistent with the interpretation that stimulation of Bcl-2 expression is not the primary target of AML1/ETO.
1	These	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
2	results	result	NOUN	NNS	Number=Plur	_	_	_	_
3	are	be	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
4	consistent	consistent	ADJ	JJ	Degree=Pos	_	_	_	_
5	with	with	ADP	IN	_	_	_	_	_
6	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
7	interpretation	interpretation	NOUN	NN	Number=Sing	_	_	_	_
8	that	that	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
9	stimulation	stimulation	NOUN	NN	Number=Sing	_	_	_	_
10	of	of	ADP	IN	_	_	_	_	_
11	Bcl	Bcl	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
12	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
13	2	2	NUM	CD	NumType=Card	_	_	_	_
14	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
15	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
16	not	not	PART	RB	_	_	_	_	_
17	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
18	primary	primary	ADJ	JJ	Degree=Pos	_	_	_	_
19	target	target	NOUN	NN	Number=Sing	_	_	_	_
20	of	of	ADP	IN	_	_	_	_	_
21	AML1	AML1	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
22	/	/	PUNCT	,	_	_	_	_	SpaceAfter=No
23	ETO	ETO	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
24	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 2386
# text = Document 003003214 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	003003214	003003214	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 2387
# text = Cloning of murine TCF-1, a T cell-specific transcription factor interacting with functional motifs in the CD3-epsilon and T cell receptor alpha enhancers.
1	Cloning	Cloning	VERB	VBG	VerbForm=Ger	_	_	_	_
2	of	of	ADP	IN	_	_	_	_	_
3	murine	murine	NOUN	NN	Number=Sing	_	_	_	_
4	TCF	TCF	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
5	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
6	1	1	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
7	,	,	PUNCT	,	_	_	_	_	_
8	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
9	T	T	PROPN	NNP	Number=Sing	_	_	_	_
10	cell	cell	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
11	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
12	specific	specific	ADJ	JJ	Degree=Pos	_	_	_	_
13	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
14	factor	factor	NOUN	NN	Number=Sing	_	_	_	_
15	interacting	interact	VERB	VBG	VerbForm=Ger	_	_	_	_
16	with	with	ADP	IN	_	_	_	_	_
17	functional	functional	ADJ	JJ	Degree=Pos	_	_	_	_
18	motifs	motif	NOUN	NNS	Number=Plur	_	_	_	_
19	in	in	ADP	IN	_	_	_	_	_
20	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
21	CD3	CD3	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
22	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
23	epsilon	epsilon	NOUN	NN	Number=Sing	_	_	_	_
24	and	and	CCONJ	CC	_	_	_	_	_
25	T	t	PROPN	NNP	Number=Sing	_	_	_	_
26	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
27	receptor	receptor	NOUN	NN	Number=Sing	_	_	_	_
28	alpha	alpha	ADP	IN	_	_	_	_	_
29	enhancers	enhancer	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
30	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 2388
# text = CD3-epsilon gene expression is confined to the T cell lineage.
1	CD3	CD3	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
2	-epsilon	-epsilon	NOUN	NN	Number=Sing	_	_	_	_
3	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
4	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
5	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
6	confined	confine	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
7	to	to	ADP	IN	_	_	_	_	_
8	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
9	T	T	PROPN	NNP	Number=Sing	_	_	_	_
10	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
11	lineage	lineage	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
12	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2389
# text = We have recently identified and cloned a human transcription factor, TCF-1, that binds to a functional element in the T lymphocyte-specific enhancer of CD3-epsilon.
1	We	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
2	have	have	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
3	recently	recently	ADV	RB	_	_	_	_	_
4	identified	identify	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
5	and	and	CCONJ	CC	_	_	_	_	_
6	cloned	clon	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
7	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
8	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
9	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
10	factor	factor	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
11	,	,	PUNCT	,	_	_	_	_	_
12	TCF	TCF	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
13	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
14	1	1	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
15	,	,	PUNCT	,	_	_	_	_	_
16	that	that	PRON	WDT	PronType=Rel	_	_	_	_
17	binds	bind	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
18	to	to	ADP	IN	_	_	_	_	_
19	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
20	functional	functional	ADJ	JJ	Degree=Pos	_	_	_	_
21	element	element	NOUN	NN	Number=Sing	_	_	_	_
22	in	in	ADP	IN	_	_	_	_	_
23	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
24	T	T	PROPN	NNP	Number=Sing	_	_	_	_
25	lymphocyte	lymphocyte	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
26	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
27	specific	specific	ADJ	JJ	Degree=Pos	_	_	_	_
28	enhancer	enhancer	NOUN	NN	Number=Sing	_	_	_	_
29	of	of	ADP	IN	_	_	_	_	_
30	CD3	CD3	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
31	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
32	epsilon	epsilon	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
33	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2390
# text = In a panel of human cell lines, TCF-1 expression was restricted to T lineage cells.
1	In	in	ADP	IN	_	_	_	_	_
2	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
3	panel	panel	NOUN	NN	Number=Sing	_	_	_	_
4	of	of	ADP	IN	_	_	_	_	_
5	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
6	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
7	lines	line	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
8	,	,	PUNCT	,	_	_	_	_	_
9	TCF	TCF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
10	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
11	1	1	NUM	CD	NumType=Card	_	_	_	_
12	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
13	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
14	restricted	restrict	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
15	to	to	PART	TO	_	_	_	_	_
16	T	t	VERB	VB	VerbForm=Inf	_	_	_	_
17	lineage	lineage	NOUN	NN	Number=Sing	_	_	_	_
18	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
19	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2391
# text = TCF-1 belonged to a novel family of genes that contain the so-called high mobility group 1 (HMG) box.
1	TCF	Tcf	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
2	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
3	1	1	NUM	CD	NumType=Card	_	_	_	_
4	belonged	belong	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
5	to	to	ADP	IN	_	_	_	_	_
6	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
7	novel	novel	NOUN	NN	Number=Sing	_	_	_	_
8	family	family	NOUN	NN	Number=Sing	_	_	_	_
9	of	of	ADP	IN	_	_	_	_	_
10	genes	gene	NOUN	NNS	Number=Plur	_	_	_	_
11	that	that	PRON	WDT	PronType=Rel	_	_	_	_
12	contain	contain	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
13	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
14	so	so	ADV	RB	_	_	_	_	SpaceAfter=No
15	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
16	called	call	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
17	high	high	ADJ	JJ	Degree=Pos	_	_	_	_
18	mobility	mobility	NOUN	NN	Number=Sing	_	_	_	_
19	group	group	NOUN	NN	Number=Sing	_	_	_	_
20	1	1	NUM	CD	NumType=Card	_	_	_	_
21	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
22	HMG	HMG	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
23	)	)	PUNCT	-RRB-	_	_	_	_	_
24	box	box	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
25	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2392
# text = Here we report the cloning of murine TCF-1.
1	Here	here	ADV	RB	PronType=Dem	_	_	_	_
2	we	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
3	report	report	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
4	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
5	cloning	cloning	NOUN	NN	Number=Sing	_	_	_	_
6	of	of	ADP	IN	_	_	_	_	_
7	murine	murine	NOUN	NN	Number=Sing	_	_	_	_
8	TCF	TCF	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
9	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
10	1	1	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
11	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2393
# text = Two splice alternatives were identified that were not previously observed in human TCF-1.
1	Two	two	NUM	CD	NumType=Card	_	_	_	_
2	splice	splice	NOUN	NN	Number=Sing	_	_	_	_
3	alternatives	alternative	NOUN	NNS	Number=Plur	_	_	_	_
4	were	be	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
5	identified	identify	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
6	that	that	PRON	WDT	PronType=Rel	_	_	_	_
7	were	be	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
8	not	not	PART	RB	_	_	_	_	_
9	previously	previously	ADV	RB	_	_	_	_	_
10	observed	observe	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
11	in	in	ADP	IN	_	_	_	_	_
12	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
13	TCF	TCF	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
14	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
15	1	1	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
16	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2394
# text = Murine and human TCF-1 displayed a 95.5% overall amino acid homology.
1	Murine	Murine	PROPN	NNP	Number=Sing	_	_	_	_
2	and	and	CCONJ	CC	_	_	_	_	_
3	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
4	TCF	TCF	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
5	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
6	1	1	NUM	CD	NumType=Card	_	_	_	_
7	displayed	display	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
8	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
9	95.5	95.5	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
10	%	%	SYM	NN	Number=Sing	_	_	_	_
11	overall	overall	ADJ	JJ	Degree=Pos	_	_	_	_
12	amino	amino	DET	DT	_	_	_	_	_
13	acid	acid	ADJ	JJ	Degree=Pos	_	_	_	_
14	homology	homology	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
15	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2395
# text = Recombinant murine and human TCF-1 recognized the same sequence motif in the CD3-epsilon enhancer as judged by gel retardation and methylation interference assays.
1	Recombinant	Recombinant	NOUN	NN	Number=Sing	_	_	_	_
2	murine	murine	NOUN	NN	Number=Sing	_	_	_	_
3	and	and	CCONJ	CC	_	_	_	_	_
4	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
5	TCF	TCF	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
6	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
7	1	1	NUM	CD	NumType=Card	_	_	_	_
8	recognized	recognize	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
9	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
10	same	same	ADJ	JJ	Degree=Pos	_	_	_	_
11	sequence	sequence	NOUN	NN	Number=Sing	_	_	_	_
12	motif	motif	NOUN	NN	Number=Sing	_	_	_	_
13	in	in	ADP	IN	_	_	_	_	_
14	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
15	CD3	CD3	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
16	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
17	epsilon	epsilon	NOUN	NN	Number=Sing	_	_	_	_
18	enhancer	enhancer	NOUN	NN	Number=Sing	_	_	_	_
19	as	as	SCONJ	IN	_	_	_	_	_
20	judged	judge	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
21	by	by	ADP	IN	_	_	_	_	_
22	gel	gel	NOUN	NN	Number=Sing	_	_	_	_
23	retardation	retardation	NOUN	NN	Number=Sing	_	_	_	_
24	and	and	CCONJ	CC	_	_	_	_	_
25	methylation	methylation	NOUN	NN	Number=Sing	_	_	_	_
26	interference	interference	NOUN	NN	Number=Sing	_	_	_	_
27	assays	assay	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	SpaceAfter=No
28	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2396
# text = With the murine cDNA clones several aspects of TCF-1 were analyzed.
1	With	with	ADP	IN	_	_	_	_	_
2	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
3	murine	murine	NOUN	NN	Number=Sing	_	_	_	_
4	cDNA	cDNa	NOUN	NN	Number=Sing	_	_	_	_
5	clones	clone	NOUN	NNS	Number=Plur	_	_	_	_
6	several	several	ADJ	JJ	Degree=Pos	_	_	_	_
7	aspects	aspect	NOUN	NNS	Number=Plur	_	_	_	_
8	of	of	ADP	IN	_	_	_	_	_
9	TCF	TCF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
10	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
11	1	1	NUM	CD	NumType=Card	_	_	_	_
12	were	be	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
13	analyzed	analyze	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	SpaceAfter=No
14	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2397
# text = First, deletion analysis revealed that a region of TCF-1 containing the HMG box was sufficient for sequence-specific binding.
1	First	first	ADV	RB	_	_	_	_	SpaceAfter=No
2	,	,	PUNCT	,	_	_	_	_	_
3	deletion	deletion	NOUN	NN	Number=Sing	_	_	_	_
4	analysis	analysis	NOUN	NN	Number=Sing	_	_	_	_
5	revealed	reveal	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
6	that	that	SCONJ	IN	_	_	_	_	_
7	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
8	region	region	NOUN	NN	Number=Sing	_	_	_	_
9	of	of	ADP	IN	_	_	_	_	_
10	TCF	TCF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
11	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
12	1	1	NUM	CD	NumType=Card	_	_	_	_
13	containing	contain	VERB	VBG	VerbForm=Ger	_	_	_	_
14	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
15	HMG	HMG	PROPN	NNP	Number=Sing	_	_	_	_
16	box	box	NOUN	NN	Number=Sing	_	_	_	_
17	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
18	sufficient	sufficient	ADJ	JJ	Degree=Pos	_	_	_	_
19	for	for	ADP	IN	_	_	_	_	_
20	sequence	sequence	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
21	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
22	specific	specific	ADJ	JJ	Degree=Pos	_	_	_	_
23	binding	binding	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
24	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2398
# text = Second, by high stringency Northern blotting and in situ hybridization, TCF-1 expression was shown to be confined to the thymus and to the T cell areas of the spleen.
1	Second	second	ADV	RB	_	_	_	_	SpaceAfter=No
2	,	,	PUNCT	,	_	_	_	_	_
3	by	by	ADP	IN	_	_	_	_	_
4	high	high	ADJ	JJ	Degree=Pos	_	_	_	_
5	stringency	stringency	NOUN	NN	Number=Sing	_	_	_	_
6	Northern	Northern	PROPN	NNP	Number=Sing	_	_	_	_
7	blotting	blott	VERB	VBG	VerbForm=Ger	_	_	_	_
8	and	and	CCONJ	CC	_	_	_	_	_
9	in	in	ADP	IN	_	_	_	_	_
10	situ	situ	NOUN	NN	Number=Sing	_	_	_	_
11	hybridization	hybridization	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
12	,	,	PUNCT	,	_	_	_	_	_
13	TCF	TCF	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
14	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
15	1	1	NUM	CD	NumType=Card	_	_	_	_
16	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
17	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
18	shown	show	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
19	to	to	PART	TO	_	_	_	_	_
20	be	be	AUX	VB	VerbForm=Inf	_	_	_	_
21	confined	confine	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
22	to	to	ADP	IN	_	_	_	_	_
23	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
24	thymus	thymus	NOUN	NN	Number=Sing	_	_	_	_
25	and	and	CCONJ	CC	_	_	_	_	_
26	to	to	ADP	IN	_	_	_	_	_
27	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
28	T	t	PROPN	NNP	Number=Sing	_	_	_	_
29	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
30	areas	area	NOUN	NNS	Number=Plur	_	_	_	_
31	of	of	ADP	IN	_	_	_	_	_
32	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
33	spleen	spleen	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
34	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2399
# text = Third, TCF-1 bound specifically to a functional T cell-specific element in the T cell receptor alpha (TCR-alpha) enhancer.
1	Third	third	ADV	RB	_	_	_	_	SpaceAfter=No
2	,	,	PUNCT	,	_	_	_	_	_
3	TCF	TCF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
4	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
5	1	1	NUM	CD	NumType=Card	_	_	_	_
6	bound	bound	NOUN	NN	Number=Sing	_	_	_	_
7	specifically	specifically	ADV	RB	_	_	_	_	_
8	to	to	ADP	IN	_	_	_	_	_
9	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
10	functional	functional	ADJ	JJ	Degree=Pos	_	_	_	_
11	T	T	PROPN	NNP	Number=Sing	_	_	_	_
12	cell	cell	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
13	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
14	specific	specific	ADJ	JJ	Degree=Pos	_	_	_	_
15	element	element	NOUN	NN	Number=Sing	_	_	_	_
16	in	in	ADP	IN	_	_	_	_	_
17	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
18	T	T	PROPN	NNP	Number=Sing	_	_	_	_
19	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
20	receptor	receptor	NOUN	NN	Number=Sing	_	_	_	_
21	alpha	alpha	NOUN	NN	Number=Sing	_	_	_	_
22	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
23	TCR	Tcr	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
24	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
25	alpha	alpha	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
26	)	)	PUNCT	-RRB-	_	_	_	_	_
27	enhancer	enhancer	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
28	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2400
# text = The T lineage-specific expression and the affinity for functional motifs in the TCR-alpha and CD3-epsilon enhancers imply an important role for TCF-1 in the establishment of the mature T cell phenotype.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	T	T	PROPN	NNP	Number=Sing	_	_	_	_
3	lineage	lineage	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
4	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
5	specific	specific	ADJ	JJ	Degree=Pos	_	_	_	_
6	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
7	and	and	CCONJ	CC	_	_	_	_	_
8	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
9	affinity	affinity	NOUN	NN	Number=Sing	_	_	_	_
10	for	for	ADP	IN	_	_	_	_	_
11	functional	functional	ADJ	JJ	Degree=Pos	_	_	_	_
12	motifs	motif	NOUN	NNS	Number=Plur	_	_	_	_
13	in	in	ADP	IN	_	_	_	_	_
14	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
15	TCR	Tcr	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
16	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
17	alpha	alpha	NOUN	NN	Number=Sing	_	_	_	_
18	and	and	CCONJ	CC	_	_	_	_	_
19	CD3	CD3	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
20	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
21	epsilon	epsilon	NOUN	NN	Number=Sing	_	_	_	_
22	enhancers	enhancer	NOUN	NNS	Number=Plur	_	_	_	_
23	imply	imply	ADV	RB	_	_	_	_	_
24	an	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
25	important	important	ADJ	JJ	Degree=Pos	_	_	_	_
26	role	role	NOUN	NN	Number=Sing	_	_	_	_
27	for	for	ADP	IN	_	_	_	_	_
28	TCF	TCF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
29	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
30	1	1	NUM	CD	NumType=Card	_	_	_	_
31	in	in	ADP	IN	_	_	_	_	_
32	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
33	establishment	establishment	NOUN	NN	Number=Sing	_	_	_	_
34	of	of	ADP	IN	_	_	_	_	_
35	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
36	mature	mature	ADJ	JJ	Degree=Pos	_	_	_	_
37	T	t	PROPN	NNP	Number=Sing	_	_	_	_
38	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
39	phenotype	phenotype	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
40	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 2401
# text = Document 003003216 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	003003216	003003216	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 2402
# text = Constitutive expression of HIV-1 tat protein in human Jurkat T cells using a BK virus vector.
1	Constitutive	Constitutive	ADJ	JJ	Degree=Pos	_	_	_	_
2	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
3	of	of	ADP	IN	_	_	_	_	_
4	HIV	HIV	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
5	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
6	1	1	NUM	CD	NumType=Card	_	_	_	_
7	tat	tat	NOUN	NN	Number=Sing	_	_	_	_
8	protein	protein	NOUN	NN	Number=Sing	_	_	_	_
9	in	in	ADP	IN	_	_	_	_	_
10	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
11	Jurkat	Jurkat	PROPN	NNP	Number=Sing	_	_	_	_
12	T	t	PROPN	NNP	Number=Sing	_	_	_	_
13	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
14	using	use	VERB	VBG	VerbForm=Ger	_	_	_	_
15	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
16	BK	BK	PROPN	NNP	Number=Sing	_	_	_	_
17	virus	virus	NOUN	NN	Number=Sing	_	_	_	_
18	vector	vector	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
19	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 2403
# text = The production and characterization of Jurkat cell lines that constitutively express functional human immune deficiency virus type 1 (HIV-1) tat protein, using a BK virus plasmid expression vector and HIV-1 tat cDNA, is described.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	production	production	NOUN	NN	Number=Sing	_	_	_	_
3	and	and	CCONJ	CC	_	_	_	_	_
4	characterization	characterization	NOUN	NN	Number=Sing	_	_	_	_
5	of	of	ADP	IN	_	_	_	_	_
6	Jurkat	Jurkat	PROPN	NNP	Number=Sing	_	_	_	_
7	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
8	lines	line	NOUN	NNS	Number=Plur	_	_	_	_
9	that	that	PRON	WDT	PronType=Rel	_	_	_	_
10	constitutively	constitutively	ADV	RB	_	_	_	_	_
11	express	express	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
12	functional	functional	ADJ	JJ	Degree=Pos	_	_	_	_
13	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
14	immune	immune	NOUN	NN	Number=Sing	_	_	_	_
15	deficiency	deficiency	NOUN	NN	Number=Sing	_	_	_	_
16	virus	virus	NOUN	NN	Number=Sing	_	_	_	_
17	type	type	NOUN	NN	Number=Sing	_	_	_	_
18	1	1	NUM	CD	NumType=Card	_	_	_	_
19	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
20	HIV	Hiv	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
21	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
22	1	1	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
23	)	)	PUNCT	-RRB-	_	_	_	_	_
24	tat	tat	NOUN	NN	Number=Sing	_	_	_	_
25	protein	protein	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
26	,	,	PUNCT	,	_	_	_	_	_
27	using	use	VERB	VBG	VerbForm=Ger	_	_	_	_
28	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
29	BK	BK	PROPN	NNP	Number=Sing	_	_	_	_
30	virus	virus	NOUN	NN	Number=Sing	_	_	_	_
31	plasmid	plasmid	NOUN	NN	Number=Sing	_	_	_	_
32	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
33	vector	vector	NOUN	NN	Number=Sing	_	_	_	_
34	and	and	CCONJ	CC	_	_	_	_	_
35	HIV	Hiv	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
36	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
37	1	1	NUM	CD	NumType=Card	_	_	_	_
38	tat	tat	NOUN	NN	Number=Sing	_	_	_	_
39	cDNA	cDNa	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
40	,	,	PUNCT	,	_	_	_	_	_
41	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
42	described	describe	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	SpaceAfter=No
43	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2404
# text = An increased growth rate of these Jurkat-tat cell lines as compared with control cell lines was observed.
1	An	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
2	increased	increase	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
3	growth	growth	NOUN	NN	Number=Sing	_	_	_	_
4	rate	rate	NOUN	NN	Number=Sing	_	_	_	_
5	of	of	ADP	IN	_	_	_	_	_
6	these	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
7	Jurkat	Jurkat	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
8	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
9	tat	tat	NOUN	NN	Number=Sing	_	_	_	_
10	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
11	lines	line	NOUN	NNS	Number=Plur	_	_	_	_
12	as	as	ADP	IN	_	_	_	_	_
13	compared	compare	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
14	with	with	ADP	IN	_	_	_	_	_
15	control	control	NOUN	NN	Number=Sing	_	_	_	_
16	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
17	lines	line	NOUN	NNS	Number=Plur	_	_	_	_
18	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
19	observed	observe	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	SpaceAfter=No
20	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 2405
# text = Document 003003220 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	003003220	003003220	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 2406
# text = RB and a novel E2F-1 binding protein in MHC class II deficient B-cell lines and normal IFN-gamma induction of the class IL transactivator CIITA in class II non-inducible RB-defective tumor lines.
1	RB	RB	PROPN	NNP	Number=Sing	_	_	_	_
2	and	and	CCONJ	CC	_	_	_	_	_
3	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
4	novel	novel	NOUN	NN	Number=Sing	_	_	_	_
5	E2F	E2f	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
6	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
7	1	1	NUM	CD	NumType=Card	_	_	_	_
8	binding	bind	VERB	VBG	VerbForm=Ger	_	_	_	_
9	protein	protein	NOUN	NN	Number=Sing	_	_	_	_
10	in	in	ADP	IN	_	_	_	_	_
11	MHC	MHC	PROPN	NNP	Number=Sing	_	_	_	_
12	class	class	NOUN	NN	Number=Sing	_	_	_	_
13	II	ii	NUM	CD	NumType=Card	_	_	_	_
14	deficient	deficient	ADJ	JJ	Degree=Pos	_	_	_	_
15	B	b	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
16	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
17	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
18	lines	line	NOUN	NNS	Number=Plur	_	_	_	_
19	and	and	CCONJ	CC	_	_	_	_	_
20	normal	normal	ADJ	JJ	Degree=Pos	_	_	_	_
21	IFN	Ifn	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
22	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
23	gamma	gamma	NOUN	NN	Number=Sing	_	_	_	_
24	induction	induction	NOUN	NN	Number=Sing	_	_	_	_
25	of	of	ADP	IN	_	_	_	_	_
26	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
27	class	class	NOUN	NN	Number=Sing	_	_	_	_
28	IL	Il	NOUN	NN	Number=Sing	_	_	_	_
29	transactivator	transactivator	NOUN	NN	Number=Sing	_	_	_	_
30	CIITA	CIITa	NOUN	NN	Number=Sing	_	_	_	_
31	in	in	ADP	IN	_	_	_	_	_
32	class	class	NOUN	NN	Number=Sing	_	_	_	_
33	II	ii	NUM	CD	NumType=Card	_	_	_	_
34	non-inducible	non-inducible	ADJ	JJ	Degree=Pos	_	_	_	_
35	RB	Rb	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
36	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
37	defective	defective	ADJ	JJ	Degree=Pos	_	_	_	_
38	tumor	tumor	NOUN	NN	Number=Sing	_	_	_	_
39	lines	line	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
40	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 2407
# text = The major histocompatibility (MHC) class II genes encode cell surface proteins that bind antigenic peptide for presentation to T-cells.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	major	major	ADJ	JJ	Degree=Pos	_	_	_	_
3	histocompatibility	histocompatibility	NOUN	NN	Number=Sing	_	_	_	_
4	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
5	MHC	MHC	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
6	)	)	PUNCT	-RRB-	_	_	_	_	_
7	class	class	NOUN	NN	Number=Sing	_	_	_	_
8	II	ii	NUM	CD	NumType=Card	_	_	_	_
9	genes	gene	NOUN	NNS	Number=Plur	_	_	_	_
10	encode	encode	NOUN	NN	Number=Sing	_	_	_	_
11	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
12	surface	surface	NOUN	NN	Number=Sing	_	_	_	_
13	proteins	protein	NOUN	NNS	Number=Plur	_	_	_	_
14	that	that	PRON	WDT	PronType=Rel	_	_	_	_
15	bind	bind	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
16	antigenic	antigenic	ADJ	JJ	Degree=Pos	_	_	_	_
17	peptide	peptide	NOUN	NN	Number=Sing	_	_	_	_
18	for	for	ADP	IN	_	_	_	_	_
19	presentation	presentation	NOUN	NN	Number=Sing	_	_	_	_
20	to	to	ADP	IN	_	_	_	_	_
21	T-	t-	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
22	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
23	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2408
# text = The class II proteins are expressed constitutively on B-cells and EBV-transformed B-cells, and are inducible by IFN-gamma on a wide variety of cell types.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	class	class	NOUN	NN	Number=Sing	_	_	_	_
3	II	ii	NUM	CD	NumType=Card	_	_	_	_
4	proteins	protein	NOUN	NNS	Number=Plur	_	_	_	_
5	are	be	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
6	expressed	express	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
7	constitutively	constitutively	ADV	RB	_	_	_	_	_
8	on	on	ADP	IN	_	_	_	_	_
9	B	b	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
10	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
11	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
12	and	and	CCONJ	CC	_	_	_	_	_
13	EBV	haEbve	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
14	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
15	transformed	transform	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
16	B	b	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
17	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
18	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
19	,	,	PUNCT	,	_	_	_	_	_
20	and	and	CCONJ	CC	_	_	_	_	_
21	are	be	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
22	inducible	inducible	ADJ	JJ	Degree=Pos	_	_	_	_
23	by	by	ADP	IN	_	_	_	_	_
24	IFN	IFN	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
25	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
26	gamma	gamma	NOUN	NN	Number=Sing	_	_	_	_
27	on	on	ADP	IN	_	_	_	_	_
28	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
29	wide	wide	ADJ	JJ	Degree=Pos	_	_	_	_
30	variety	variety	NOUN	NN	Number=Sing	_	_	_	_
31	of	of	ADP	IN	_	_	_	_	_
32	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
33	types	type	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
34	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2409
# text = Retinoblastoma protein (RB) is a tumor suppressor and functions as a transcriptional repressor by binding and inactivating the transactivator E2F-I.
1	Retinoblastoma	Retinoblastoma	NOUN	NN	Number=Sing	_	_	_	_
2	protein	protein	NOUN	NN	Number=Sing	_	_	_	_
3	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
4	RB	RB	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
5	)	)	PUNCT	-RRB-	_	_	_	_	_
6	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
7	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
8	tumor	tumor	NOUN	NN	Number=Sing	_	_	_	_
9	suppressor	suppressor	NOUN	NN	Number=Sing	_	_	_	_
10	and	and	CCONJ	CC	_	_	_	_	_
11	functions	function	NOUN	NNS	Number=Plur	_	_	_	_
12	as	as	ADP	IN	_	_	_	_	_
13	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
14	transcriptional	transcriptional	ADJ	JJ	Degree=Pos	_	_	_	_
15	repressor	repressor	NOUN	NN	Number=Sing	_	_	_	_
16	by	by	SCONJ	IN	_	_	_	_	_
17	binding	bind	VERB	VBG	VerbForm=Ger	_	_	_	_
18	and	and	CCONJ	CC	_	_	_	_	_
19	inactivating	inactivat	VERB	VBG	VerbForm=Ger	_	_	_	_
20	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
21	transactivator	transactivator	NOUN	NN	Number=Sing	_	_	_	_
22	E2F	E2F	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
23	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
24	I.	I.	PROPN	NNP	Number=Sing	_	_	_	_

# sent_id = 2410
# text = RB-defective tumor lines are non-inducible for MHC class II by IFN-gamma, or very weakly inducible, but transfection of 2 different lines with RB expression vectors re-establishes or substantially enhances class II inducibility.
1	RB	Rb	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
2	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
3	defective	defective	ADJ	JJ	Degree=Pos	_	_	_	_
4	tumor	tumor	NOUN	NN	Number=Sing	_	_	_	_
5	lines	line	NOUN	NNS	Number=Plur	_	_	_	_
6	are	be	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
7	non-inducible	non-inducible	ADJ	JJ	Degree=Pos	_	_	_	_
8	for	for	ADP	IN	_	_	_	_	_
9	MHC	MHC	PROPN	NNP	Number=Sing	_	_	_	_
10	class	class	NOUN	NN	Number=Sing	_	_	_	_
11	II	ii	NUM	CD	NumType=Card	_	_	_	_
12	by	by	ADP	IN	_	_	_	_	_
13	IFN	IFN	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
14	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
15	gamma	gamma	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
16	,	,	PUNCT	,	_	_	_	_	_
17	or	or	CCONJ	CC	_	_	_	_	_
18	very	very	ADV	RB	_	_	_	_	_
19	weakly	weakly	ADV	RB	_	_	_	_	_
20	inducible	inducible	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
21	,	,	PUNCT	,	_	_	_	_	_
22	but	but	CCONJ	CC	_	_	_	_	_
23	transfection	transfection	NOUN	NN	Number=Sing	_	_	_	_
24	of	of	ADP	IN	_	_	_	_	_
25	2	2	NUM	CD	NumType=Card	_	_	_	_
26	different	different	ADJ	JJ	Degree=Pos	_	_	_	_
27	lines	line	NOUN	NNS	Number=Plur	_	_	_	_
28	with	with	ADP	IN	_	_	_	_	_
29	RB	RB	PROPN	NNP	Number=Sing	_	_	_	_
30	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
31	vectors	vector	NOUN	NNS	Number=Plur	_	_	_	_
32	re	re	ADP	IN	_	_	_	_	SpaceAfter=No
33	-establishes	-establish	NOUN	NNS	Number=Plur	_	_	_	_
34	or	or	CCONJ	CC	_	_	_	_	_
35	substantially	substantially	ADV	RB	_	_	_	_	_
36	enhances	enhance	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
37	class	class	NOUN	NN	Number=Sing	_	_	_	_
38	II	ii	NUM	CD	NumType=Card	_	_	_	_
39	inducibility	inducibility	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
40	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2411
# text = Therefore, we examined the RB status of a series of B-cell mutants that are defective in class II expression, generated either in vitro or derived from Bare Lymphocyte Syndrome (BLS) patients.
1	Therefore	therefore	ADV	RB	_	_	_	_	SpaceAfter=No
2	,	,	PUNCT	,	_	_	_	_	_
3	we	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
4	examined	examin	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
5	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
6	RB	RB	PROPN	NNP	Number=Sing	_	_	_	_
7	status	status	NOUN	NN	Number=Sing	_	_	_	_
8	of	of	ADP	IN	_	_	_	_	_
9	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
10	series	series	NOUN	NN	Number=Sing	_	_	_	_
11	of	of	ADP	IN	_	_	_	_	_
12	B	b	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
13	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
14	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
15	mutants	mutant	NOUN	NNS	Number=Plur	_	_	_	_
16	that	that	PRON	WDT	PronType=Rel	_	_	_	_
17	are	be	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
18	defective	defective	ADJ	JJ	Degree=Pos	_	_	_	_
19	in	in	ADP	IN	_	_	_	_	_
20	class	class	NOUN	NN	Number=Sing	_	_	_	_
21	II	ii	NUM	CD	NumType=Card	_	_	_	_
22	expression	expression	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
23	,	,	PUNCT	,	_	_	_	_	_
24	generated	generate	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
25	either	either	CCONJ	CC	_	_	_	_	_
26	in	in	ADP	IN	_	_	_	_	_
27	vitro	vitro	NOUN	NN	Number=Sing	_	_	_	_
28	or	or	CCONJ	CC	_	_	_	_	_
29	derived	derive	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
30	from	from	ADP	IN	_	_	_	_	_
31	Bare	bare	PROPN	NNP	Number=Sing	_	_	_	_
32	Lymphocyte	Lymphocyte	PROPN	NNP	Number=Sing	_	_	_	_
33	Syndrome	Syndrome	PROPN	NNP	Number=Sing	_	_	_	_
34	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
35	BLS	BLS	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
36	)	)	PUNCT	-RRB-	_	_	_	_	_
37	patients	patient	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
38	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2412
# text = Nuclear matrix-bound RB was detectable in all cases, indicating that loss of RB is not responsible for decreased class II expression in these lines.
1	Nuclear	nuclear	ADJ	JJ	Degree=Pos	_	_	_	_
2	matrix	matrix	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
3	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
4	bound	bound	ADJ	JJ	Degree=Pos	_	_	_	_
5	RB	Rb	NOUN	NN	Number=Sing	_	_	_	_
6	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
7	detectable	detectable	ADJ	JJ	Degree=Pos	_	_	_	_
8	in	in	ADP	IN	_	_	_	_	_
9	all	all	DET	DT	_	_	_	_	_
10	cases	case	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
11	,	,	PUNCT	,	_	_	_	_	_
12	indicating	indicate	VERB	VBG	VerbForm=Ger	_	_	_	_
13	that	that	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
14	loss	loss	NOUN	NN	Number=Sing	_	_	_	_
15	of	of	ADP	IN	_	_	_	_	_
16	RB	RB	PROPN	NNP	Number=Sing	_	_	_	_
17	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
18	not	not	PART	RB	_	_	_	_	_
19	responsible	responsible	ADJ	JJ	Degree=Pos	_	_	_	_
20	for	for	ADP	IN	_	_	_	_	_
21	decreased	decrease	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
22	class	class	NOUN	NN	Number=Sing	_	_	_	_
23	II	ii	NUM	CD	NumType=Card	_	_	_	_
24	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
25	in	in	ADP	IN	_	_	_	_	_
26	these	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
27	lines	line	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
28	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2413
# text = A second E2F-I binding protein, most likely DP-I, was also apparently normal in both class II-positive and -negative B-cell lines.
1	A	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
2	second	second	ADJ	JJ	Degree=Pos|NumType=Ord	_	_	_	_
3	E2F	E2f	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
4	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
5	I	I	PRON	PRP	Case=Nom|Number=Sing|Person=1|PronType=Prs	_	_	_	_
6	binding	bind	VERB	VBG	VerbForm=Ger	_	_	_	_
7	protein	protein	ADV	RB	_	_	_	_	SpaceAfter=No
8	,	,	PUNCT	,	_	_	_	_	_
9	most	most	ADJ	JJS	Degree=Sup	_	_	_	_
10	likely	likely	ADJ	JJ	Degree=Pos	_	_	_	_
11	DP	Dp	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
12	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
13	I	I	PRON	PRP	Case=Nom|Number=Sing|Person=1|PronType=Prs	_	_	_	SpaceAfter=No
14	,	,	PUNCT	,	_	_	_	_	_
15	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
16	also	also	ADV	RB	_	_	_	_	_
17	apparently	apparently	ADV	RB	_	_	_	_	_
18	normal	normal	ADJ	JJ	Degree=Pos	_	_	_	_
19	in	in	ADP	IN	_	_	_	_	_
20	both	both	DET	DT	_	_	_	_	_
21	class	class	NOUN	NN	Number=Sing	_	_	_	_
22	II	ii	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
23	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
24	positive	positive	ADJ	JJ	Degree=Pos	_	_	_	_
25	and	and	CCONJ	CC	_	_	_	_	_
26	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
27	negative	negative	ADJ	JJ	Degree=Pos	_	_	_	_
28	B	b	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
29	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
30	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
31	lines	line	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
32	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2414
# text = We also examined the IFN-gamma induction of CIITA in RB-defective lines.
1	We	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
2	also	also	ADV	RB	_	_	_	_	_
3	examined	examin	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
4	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
5	IFN	Ifn	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
6	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
7	gamma	gamma	NOUN	NN	Number=Sing	_	_	_	_
8	induction	induction	NOUN	NN	Number=Sing	_	_	_	_
9	of	of	ADP	IN	_	_	_	_	_
10	CIITA	CIITA	PROPN	NNP	Number=Sing	_	_	_	_
11	in	in	ADP	IN	_	_	_	_	_
12	RB	RB	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
13	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
14	defective	defective	ADJ	JJ	Degree=Pos	_	_	_	_
15	lines	line	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
16	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2415
# text = CIITA is a class II gene transactivator known to be defective in one form of BLS and to be required for the induction of MHC class II by IFN-gamma.
1	CIITA	CIITA	PROPN	NNP	Number=Sing	_	_	_	_
2	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
3	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
4	class	class	NOUN	NN	Number=Sing	_	_	_	_
5	II	ii	NUM	CD	NumType=Card	_	_	_	_
6	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
7	transactivator	transactivator	NOUN	NN	Number=Sing	_	_	_	_
8	known	know	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
9	to	to	PART	TO	_	_	_	_	_
10	be	be	AUX	VB	VerbForm=Inf	_	_	_	_
11	defective	defective	ADJ	JJ	Degree=Pos	_	_	_	_
12	in	in	ADP	IN	_	_	_	_	_
13	one	one	NUM	CD	NumType=Card	_	_	_	_
14	form	form	NOUN	NN	Number=Sing	_	_	_	_
15	of	of	ADP	IN	_	_	_	_	_
16	BLS	BLS	PROPN	NNP	Number=Sing	_	_	_	_
17	and	and	CCONJ	CC	_	_	_	_	_
18	to	to	PART	TO	_	_	_	_	_
19	be	be	AUX	VB	VerbForm=Inf	_	_	_	_
20	required	require	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
21	for	for	ADP	IN	_	_	_	_	_
22	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
23	induction	induction	NOUN	NN	Number=Sing	_	_	_	_
24	of	of	ADP	IN	_	_	_	_	_
25	MHC	MHC	PROPN	NNP	Number=Sing	_	_	_	_
26	class	class	NOUN	NN	Number=Sing	_	_	_	_
27	II	ii	NUM	CD	NumType=Card	_	_	_	_
28	by	by	ADP	IN	_	_	_	_	_
29	IFN	IFN	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
30	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
31	gamma	gamma	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
32	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2416
# text = CIITA mRNA is normally inducible by IFN-gamma in class II non-inducible, RB-defective lines, and in one line, re-expression of RB has no effect on CIITA mRNA induction levels.
1	CIITA	CIITA	PROPN	NNP	Number=Sing	_	_	_	_
2	mRNA	mRNA	PROPN	NNP	Number=Sing	_	_	_	_
3	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
4	normally	normally	ADV	RB	_	_	_	_	_
5	inducible	inducible	ADJ	JJ	Degree=Pos	_	_	_	_
6	by	by	ADP	IN	_	_	_	_	_
7	IFN	IFN	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
8	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
9	gamma	gamma	NOUN	NN	Number=Sing	_	_	_	_
10	in	in	ADP	IN	_	_	_	_	_
11	class	class	NOUN	NN	Number=Sing	_	_	_	_
12	II	ii	NUM	CD	NumType=Card	_	_	_	_
13	non-inducible	non-inducible	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
14	,	,	PUNCT	,	_	_	_	_	_
15	RB	Rb	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
16	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
17	defective	defective	ADJ	JJ	Degree=Pos	_	_	_	_
18	lines	line	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
19	,	,	PUNCT	,	_	_	_	_	_
20	and	and	CCONJ	CC	_	_	_	_	_
21	in	in	ADP	IN	_	_	_	_	_
22	one	one	NUM	CD	NumType=Card	_	_	_	_
23	line	line	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
24	,	,	PUNCT	,	_	_	_	_	_
25	re-expression	re-expression	NOUN	NN	Number=Sing	_	_	_	_
26	of	of	ADP	IN	_	_	_	_	_
27	RB	RB	PROPN	NNP	Number=Sing	_	_	_	_
28	has	have	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
29	no	no	DET	DT	_	_	_	_	_
30	effect	effect	NOUN	NN	Number=Sing	_	_	_	_
31	on	on	ADP	IN	_	_	_	_	_
32	CIITA	CIITa	PROPN	NNP	Number=Sing	_	_	_	_
33	mRNA	mRNa	PROPN	NNP	Number=Sing	_	_	_	_
34	induction	induction	NOUN	NN	Number=Sing	_	_	_	_
35	levels	level	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
36	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2417
# text = Thus, the block in MHC class II inducibility in RB-defective cells is not due to a block in CIITA inducibility.
1	Thus	thus	ADV	RB	_	_	_	_	SpaceAfter=No
2	,	,	PUNCT	,	_	_	_	_	_
3	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
4	block	block	NOUN	NN	Number=Sing	_	_	_	_
5	in	in	ADP	IN	_	_	_	_	_
6	MHC	MHC	PROPN	NNP	Number=Sing	_	_	_	_
7	class	class	NOUN	NN	Number=Sing	_	_	_	_
8	II	ii	NUM	CD	NumType=Card	_	_	_	_
9	inducibility	inducibility	NOUN	NN	Number=Sing	_	_	_	_
10	in	in	ADP	IN	_	_	_	_	_
11	RB	RB	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
12	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
13	defective	defective	ADJ	JJ	Degree=Pos	_	_	_	_
14	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
15	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
16	not	not	PART	RB	_	_	_	_	_
17	due	due	ADP	IN	_	_	_	_	_
18	to	to	ADP	IN	_	_	_	_	_
19	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
20	block	block	NOUN	NN	Number=Sing	_	_	_	_
21	in	in	ADP	IN	_	_	_	_	_
22	CIITA	CIITA	PROPN	NNP	Number=Sing	_	_	_	_
23	inducibility	inducibility	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
24	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 2418
# text = Document 003003224 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	003003224	003003224	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 2419
# text = The rhombotin family of cysteine-rich LIM-domain oncogenes: distinct members are involved in T-cell translocations to human chromosomes 11p15 and 11p13.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	rhombotin	rhombotin	ADJ	JJ	Degree=Pos	_	_	_	_
3	family	family	NOUN	NN	Number=Sing	_	_	_	_
4	of	of	ADP	IN	_	_	_	_	_
5	cysteine	cysteine	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
6	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
7	rich	rich	ADJ	JJ	Degree=Pos	_	_	_	_
8	LIM	LIm	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
9	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
10	domain	domain	NOUN	NN	Number=Sing	_	_	_	_
11	oncogenes	oncogene	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
12	:	:	PUNCT	:	_	_	_	_	_
13	distinct	distinct	ADJ	JJ	Degree=Pos	_	_	_	_
14	members	member	NOUN	NNS	Number=Plur	_	_	_	_
15	are	be	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
16	involved	involved	ADJ	JJ	Degree=Pos	_	_	_	_
17	in	in	ADP	IN	_	_	_	_	_
18	T-	t-	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
19	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
20	translocations	translocation	NOUN	NNS	Number=Plur	_	_	_	_
21	to	to	ADP	IN	_	_	_	_	_
22	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
23	chromosomes	chromosome	NOUN	NNS	Number=Plur	_	_	_	_
24	11p15	11p15	NUM	CD	NumType=Card	_	_	_	_
25	and	and	CCONJ	CC	_	_	_	_	_
26	11p13	11p13	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
27	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 2420
# text = A chromosomal translocation in a T-cell leukemia involving the short arm of human chromosome 11 at band 11p15 disrupts the rhombotin gene.
1	A	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
2	chromosomal	chromosomal	ADJ	JJ	Degree=Pos	_	_	_	_
3	translocation	translocation	NOUN	NN	Number=Sing	_	_	_	_
4	in	in	ADP	IN	_	_	_	_	_
5	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
6	T-	t-	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
7	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
8	leukemia	leukemia	NOUN	NN	Number=Sing	_	_	_	_
9	involving	involve	VERB	VBG	VerbForm=Ger	_	_	_	_
10	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
11	short	short	ADJ	JJ	Degree=Pos	_	_	_	_
12	arm	arm	NOUN	NN	Number=Sing	_	_	_	_
13	of	of	ADP	IN	_	_	_	_	_
14	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
15	chromosome	chromosome	NOUN	NN	Number=Sing	_	_	_	_
16	11	11	NUM	CD	NumType=Card	_	_	_	_
17	at	at	ADP	IN	_	_	_	_	_
18	band	band	NOUN	NN	Number=Sing	_	_	_	_
19	11p15	11p15	NUM	CD	NumType=Card	_	_	_	_
20	disrupts	disrupt	NOUN	NNS	Number=Plur	_	_	_	_
21	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
22	rhombotin	rhombotin	ADJ	JJ	Degree=Pos	_	_	_	_
23	gene	gene	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
24	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2421
# text = This gene encodes a protein with duplicated cysteine-rich regions called LIM domains, which show homology to zinc-binding proteins and to iron-sulfur centers of ferredoxins.
1	This	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
2	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
3	encodes	encode	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
4	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
5	protein	protein	NOUN	NN	Number=Sing	_	_	_	_
6	with	with	ADP	IN	_	_	_	_	_
7	duplicated	duplicate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
8	cysteine	cysteine	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
9	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
10	rich	rich	ADJ	JJ	Degree=Pos	_	_	_	_
11	regions	region	NOUN	NNS	Number=Plur	_	_	_	_
12	called	call	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
13	LIM	LIm	NOUN	NN	Number=Sing	_	_	_	_
14	domains	domain	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
15	,	,	PUNCT	,	_	_	_	_	_
16	which	which	PRON	WDT	PronType=Rel	_	_	_	_
17	show	show	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
18	homology	homology	NOUN	NN	Number=Sing	_	_	_	_
19	to	to	ADP	IN	_	_	_	_	_
20	zinc	zinc	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
21	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
22	binding	bind	VERB	VBG	VerbForm=Ger	_	_	_	_
23	proteins	protein	NOUN	NNS	Number=Plur	_	_	_	_
24	and	and	CCONJ	CC	_	_	_	_	_
25	to	to	ADP	IN	_	_	_	_	_
26	iron	iron	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
27	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
28	sulfur	sulfur	NOUN	NN	Number=Sing	_	_	_	_
29	centers	center	NOUN	NNS	Number=Plur	_	_	_	_
30	of	of	ADP	IN	_	_	_	_	_
31	ferredoxins	ferredoxin	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
32	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2422
# text = Two homologues of the rhombotin gene have now been isolated.
1	Two	two	NUM	CD	NumType=Card	_	_	_	_
2	homologues	homologue	NOUN	NNS	Number=Plur	_	_	_	_
3	of	of	ADP	IN	_	_	_	_	_
4	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
5	rhombotin	rhombotin	ADJ	JJ	Degree=Pos	_	_	_	_
6	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
7	have	have	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
8	now	now	ADV	RB	_	_	_	_	_
9	been	be	AUX	VBN	Tense=Past|VerbForm=Part	_	_	_	_
10	isolated	isolate	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	SpaceAfter=No
11	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2423
# text = One of these, designated Rhom-2, is located on human chromosome 11 at band 11p13, where a cluster of T-cell leukemia-specific translocations occur; all translocation breakpoints at 11p13 are upstream of the Rhom-2 gene.
1	One	one	NUM	CD	NumType=Card	_	_	_	_
2	of	of	ADP	IN	_	_	_	_	_
3	these	these	PRON	DT	Number=Plur|PronType=Dem	_	_	_	SpaceAfter=No
4	,	,	PUNCT	,	_	_	_	_	_
5	designated	designate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
6	Rhom	rhom	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
7	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
8	2	2	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
9	,	,	PUNCT	,	_	_	_	_	_
10	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
11	located	locate	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
12	on	on	ADP	IN	_	_	_	_	_
13	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
14	chromosome	chromosome	NOUN	NN	Number=Sing	_	_	_	_
15	11	11	NUM	CD	NumType=Card	_	_	_	_
16	at	at	ADP	IN	_	_	_	_	_
17	band	band	NOUN	NN	Number=Sing	_	_	_	_
18	11p13	11p13	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
19	,	,	PUNCT	,	_	_	_	_	_
20	where	where	ADV	WRB	PronType=Rel	_	_	_	_
21	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
22	cluster	cluster	NOUN	NN	Number=Sing	_	_	_	_
23	of	of	ADP	IN	_	_	_	_	_
24	T-	t-	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
25	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
26	leukemia	leukemia	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
27	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
28	specific	specific	ADJ	JJ	Degree=Pos	_	_	_	_
29	translocations	translocation	NOUN	NNS	Number=Plur	_	_	_	_
30	occur	occur	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
31	;	;	PUNCT	,	_	_	_	_	_
32	all	all	DET	DT	_	_	_	_	_
33	translocation	translocation	NOUN	NN	Number=Sing	_	_	_	_
34	breakpoints	breakpoint	NOUN	NNS	Number=Plur	_	_	_	_
35	at	at	ADP	IN	_	_	_	_	_
36	11p13	11p13	NUM	CD	NumType=Card	_	_	_	_
37	are	be	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
38	upstream	upstream	ADJ	JJ	Degree=Pos	_	_	_	_
39	of	of	ADP	IN	_	_	_	_	_
40	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
41	Rhom	rhom	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
42	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
43	2	2	NUM	CD	NumType=Card	_	_	_	_
44	gene	gene	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
45	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2424
# text = Human and mouse Rhom-2 are highly conserved and, like rhombotin, encode two tandem cysteine-rich LIM domains.
1	Human	human	ADJ	JJ	Degree=Pos	_	_	_	_
2	and	and	CCONJ	CC	_	_	_	_	_
3	mouse	mouse	NOUN	NN	Number=Sing	_	_	_	_
4	Rhom	rhom	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
5	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
6	2	2	NUM	CD	NumType=Card	_	_	_	_
7	are	be	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
8	highly	highly	ADV	RB	_	_	_	_	_
9	conserved	conserve	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
10	and	and	CCONJ	CC	_	_	_	_	SpaceAfter=No
11	,	,	PUNCT	,	_	_	_	_	_
12	like	like	ADP	IN	_	_	_	_	_
13	rhombotin	rhombotin	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
14	,	,	PUNCT	,	_	_	_	_	_
15	encode	encode	NOUN	NN	Number=Sing	_	_	_	_
16	two	two	NUM	CD	NumType=Card	_	_	_	_
17	tandem	tandem	NOUN	NN	Number=Sing	_	_	_	_
18	cysteine	cysteine	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
19	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
20	rich	rich	ADJ	JJ	Degree=Pos	_	_	_	_
21	LIM	LIm	NOUN	NN	Number=Sing	_	_	_	_
22	domains	domain	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
23	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2425
# text = Rhom-2 mRNA is expressed in early mouse development in central nervous system, lung, kidney, liver, and spleen but only very low levels occur in thymus.
1	Rhom	Rhom	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
2	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
3	2	2	NUM	CD	NumType=Card	_	_	_	_
4	mRNA	mRNa	NOUN	NN	Number=Sing	_	_	_	_
5	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
6	expressed	express	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
7	in	in	ADP	IN	_	_	_	_	_
8	early	early	ADJ	JJ	Degree=Pos	_	_	_	_
9	mouse	mouse	NOUN	NN	Number=Sing	_	_	_	_
10	development	development	NOUN	NN	Number=Sing	_	_	_	_
11	in	in	ADP	IN	_	_	_	_	_
12	central	central	ADJ	JJ	Degree=Pos	_	_	_	_
13	nervous	nervous	ADJ	JJ	Degree=Pos	_	_	_	_
14	system	system	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
15	,	,	PUNCT	,	_	_	_	_	_
16	lung	lung	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
17	,	,	PUNCT	,	_	_	_	_	_
18	kidney	kidney	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
19	,	,	PUNCT	,	_	_	_	_	_
20	liver	liver	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
21	,	,	PUNCT	,	_	_	_	_	_
22	and	and	CCONJ	CC	_	_	_	_	_
23	spleen	spleen	NOUN	NN	Number=Sing	_	_	_	_
24	but	but	CCONJ	CC	_	_	_	_	_
25	only	only	ADV	RB	_	_	_	_	_
26	very	very	ADV	RB	_	_	_	_	_
27	low	low	ADJ	JJ	Degree=Pos	_	_	_	_
28	levels	level	NOUN	NNS	Number=Plur	_	_	_	_
29	occur	occur	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
30	in	in	ADP	IN	_	_	_	_	_
31	thymus	thymus	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
32	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2426
# text = The other gene, designated Rhom-3, is not on chromosome 11 but also retains homology to the LIM domain of rhombotin.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	other	other	ADJ	JJ	Degree=Pos	_	_	_	_
3	gene	gene	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
4	,	,	PUNCT	,	_	_	_	_	_
5	designated	designate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
6	Rhom	rhom	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
7	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
8	3	3	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
9	,	,	PUNCT	,	_	_	_	_	_
10	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
11	not	not	PART	RB	_	_	_	_	_
12	on	on	ADP	IN	_	_	_	_	_
13	chromosome	chromosome	NOUN	NN	Number=Sing	_	_	_	_
14	11	11	NUM	CD	NumType=Card	_	_	_	_
15	but	but	CCONJ	CC	_	_	_	_	_
16	also	also	ADV	RB	_	_	_	_	_
17	retains	retain	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
18	homology	homology	NOUN	NN	Number=Sing	_	_	_	_
19	to	to	ADP	IN	_	_	_	_	_
20	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
21	LIM	LIM	PROPN	NNP	Number=Sing	_	_	_	_
22	domain	domain	NOUN	NN	Number=Sing	_	_	_	_
23	of	of	ADP	IN	_	_	_	_	_
24	rhombotin	rhombotin	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
25	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2427
# text = Since the Rhom-2 gene is such a common site of chromosomal damage in T-cell tumors, the consistency of translocations near the rhombotin gene was further examined.
1	Since	since	SCONJ	IN	_	_	_	_	_
2	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
3	Rhom	rhom	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
4	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
5	2	2	NUM	CD	NumType=Card	_	_	_	_
6	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
7	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
8	such	such	DET	PDT	_	_	_	_	_
9	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
10	common	common	ADJ	JJ	Degree=Pos	_	_	_	_
11	site	site	NOUN	NN	Number=Sing	_	_	_	_
12	of	of	ADP	IN	_	_	_	_	_
13	chromosomal	chromosomal	ADJ	JJ	Degree=Pos	_	_	_	_
14	damage	damage	NOUN	NN	Number=Sing	_	_	_	_
15	in	in	ADP	IN	_	_	_	_	_
16	T-	t-	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
17	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
18	tumors	tumor	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
19	,	,	PUNCT	,	_	_	_	_	_
20	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
21	consistency	consistency	NOUN	NN	Number=Sing	_	_	_	_
22	of	of	ADP	IN	_	_	_	_	_
23	translocations	translocation	NOUN	NNS	Number=Plur	_	_	_	_
24	near	near	ADP	IN	_	_	_	_	_
25	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
26	rhombotin	rhombotin	NOUN	NN	Number=Sing	_	_	_	_
27	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
28	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
29	further	further	ADV	RB	_	_	_	_	_
30	examined	examin	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	SpaceAfter=No
31	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2428
# text = A second translocation adjacent to rhombotin was found and at the same position as in the previous example.
1	A	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
2	second	second	ADJ	JJ	Degree=Pos|NumType=Ord	_	_	_	_
3	translocation	translocation	NOUN	NN	Number=Sing	_	_	_	_
4	adjacent	adjacent	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
5	to	to	PART	TO	_	_	_	_	_
6	rhombotin	rhombotin	VERB	VB	VerbForm=Inf	_	_	_	_
7	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
8	found	find	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
9	and	and	CCONJ	CC	_	_	_	_	_
10	at	at	ADP	IN	_	_	_	_	_
11	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
12	same	same	ADJ	JJ	Degree=Pos	_	_	_	_
13	position	position	NOUN	NN	Number=Sing	_	_	_	_
14	as	as	ADP	IN	_	_	_	_	_
15	in	in	ADP	IN	_	_	_	_	_
16	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
17	previous	previous	ADJ	JJ	Degree=Pos	_	_	_	_
18	example	example	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
19	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2429
# text = Therefore, chromosome bands 11p15 (rhombotin) and 11p13 (Rhom-2) are consistent sites of chromosome translocation in T-cell leukemia, with the 11p15 target more rarely involved.
1	Therefore	therefore	ADV	RB	_	_	_	_	SpaceAfter=No
2	,	,	PUNCT	,	_	_	_	_	_
3	chromosome	chromosome	DET	DT	_	_	_	_	_
4	bands	band	NOUN	NNS	Number=Plur	_	_	_	_
5	11p15	11p15	NUM	CD	NumType=Card	_	_	_	_
6	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
7	rhombotin	rhombotin	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
8	)	)	PUNCT	-RRB-	_	_	_	_	_
9	and	and	CCONJ	CC	_	_	_	_	_
10	11p13	11p13	NUM	CD	NumType=Card	_	_	_	_
11	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
12	Rhom	rhom	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
13	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
14	2	2	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
15	)	)	PUNCT	-RRB-	_	_	_	_	_
16	are	be	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
17	consistent	consistent	ADJ	JJ	Degree=Pos	_	_	_	_
18	sites	site	NOUN	NNS	Number=Plur	_	_	_	_
19	of	of	ADP	IN	_	_	_	_	_
20	chromosome	chromosome	DET	DT	_	_	_	_	_
21	translocation	translocation	NOUN	NN	Number=Sing	_	_	_	_
22	in	in	ADP	IN	_	_	_	_	_
23	T-	t-	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
24	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
25	leukemia	leukemia	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
26	,	,	PUNCT	,	_	_	_	_	_
27	with	with	ADP	IN	_	_	_	_	_
28	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
29	11p15	11p15	NUM	CD	NumType=Card	_	_	_	_
30	target	target	NOUN	NN	Number=Sing	_	_	_	_
31	more	more	ADV	RBR	_	_	_	_	_
32	rarely	rarely	ADV	RB	_	_	_	_	_
33	involved	involved	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
34	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2430
# text = The results define the rhombotin gene family as a class of T-cell oncogenes with duplicated cysteine-rich LIM domains.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	results	result	NOUN	NNS	Number=Plur	_	_	_	_
3	define	define	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
4	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
5	rhombotin	rhombotin	NOUN	NN	Number=Sing	_	_	_	_
6	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
7	family	family	NOUN	NN	Number=Sing	_	_	_	_
8	as	as	ADP	IN	_	_	_	_	_
9	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
10	class	class	NOUN	NN	Number=Sing	_	_	_	_
11	of	of	ADP	IN	_	_	_	_	_
12	T-	t-	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
13	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
14	oncogenes	oncogene	NOUN	NNS	Number=Plur	_	_	_	_
15	with	with	ADP	IN	_	_	_	_	_
16	duplicated	duplicate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
17	cysteine	cysteine	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
18	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
19	rich	rich	ADJ	JJ	Degree=Pos	_	_	_	_
20	LIM	LIm	NOUN	NN	Number=Sing	_	_	_	_
21	domains	domain	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
22	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 2431
# text = Document 003003225 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	003003225	003003225	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 2432
# text = Aiolos transcription factor controls cell death in T cells by regulating Bcl-2 expression and its cellular localization.
1	Aiolos	Aiolos	PROPN	NNP	Number=Sing	_	_	_	_
2	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
3	factor	factor	NOUN	NN	Number=Sing	_	_	_	_
4	controls	controls	NOUN	NN	Number=Sing	_	_	_	_
5	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
6	death	death	NOUN	NN	Number=Sing	_	_	_	_
7	in	in	ADP	IN	_	_	_	_	_
8	T	t	PROPN	NNP	Number=Sing	_	_	_	_
9	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
10	by	by	SCONJ	IN	_	_	_	_	_
11	regulating	regulate	VERB	VBG	VerbForm=Ger	_	_	_	_
12	Bcl	Bcl	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
13	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
14	2	2	NUM	CD	NumType=Card	_	_	_	_
15	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
16	and	and	CCONJ	CC	_	_	_	_	_
17	its	its	PRON	PRP$	Gender=Neut|Number=Sing|Person=3|Poss=Yes|PronType=Prs	_	_	_	_
18	cellular	cellular	ADJ	JJ	Degree=Pos	_	_	_	_
19	localization	localization	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
20	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 2433
# text = We searched for proteins that interact with Ras in interleukin (IL)-2-stimulated or IL-2-deprived cells, and found that the transcription factor Aiolos interacts with Ras.
1	We	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
2	searched	search	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
3	for	for	ADP	IN	_	_	_	_	_
4	proteins	protein	NOUN	NNS	Number=Plur	_	_	_	_
5	that	that	PRON	WDT	PronType=Rel	_	_	_	_
6	interact	interact	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
7	with	with	ADP	IN	_	_	_	_	_
8	Ras	Ras	PROPN	NNP	Number=Sing	_	_	_	_
9	in	in	ADP	IN	_	_	_	_	_
10	interleukin	interleukin	PROPN	NNP	Number=Sing	_	_	_	_
11	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
12	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
13	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
14	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
15	2	2	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
16	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
17	stimulated	stimulate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
18	or	or	CCONJ	CC	_	_	_	_	_
19	IL	Il	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
20	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
21	2	2	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
22	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
23	deprived	deprive	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
24	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
25	,	,	PUNCT	,	_	_	_	_	_
26	and	and	CCONJ	CC	_	_	_	_	_
27	found	find	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
28	that	that	SCONJ	IN	_	_	_	_	_
29	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
30	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
31	factor	factor	NOUN	NN	Number=Sing	_	_	_	_
32	Aiolos	Aiolos	PROPN	NNP	Number=Sing	_	_	_	_
33	interacts	interact	NOUN	NNS	Number=Plur	_	_	_	_
34	with	with	ADP	IN	_	_	_	_	_
35	Ras	Ras	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
36	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2434
# text = The Ras-Aiolos interaction was confirmed in vitro and in vivo by co-immunoprecipitation.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	Ras	Ras	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
3	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
4	Aiolos	Aiolos	PROPN	NNP	Number=Sing	_	_	_	_
5	interaction	interaction	NOUN	NN	Number=Sing	_	_	_	_
6	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
7	confirmed	confirm	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
8	in	in	ADP	IN	_	_	_	_	_
9	vitro	vitro	NOUN	NN	Number=Sing	_	_	_	_
10	and	and	CCONJ	CC	_	_	_	_	_
11	in	in	ADP	IN	_	_	_	_	_
12	vivo	vivo	NOUN	NN	Number=Sing	_	_	_	_
13	by	by	ADP	IN	_	_	_	_	_
14	co-immunoprecipitation	co-immunoprecipitation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
15	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2435
# text = Indirect immunofluorescence shows that IL-2 controls the cellular distribution of Aiolos and induces its tyrosine phosphorylation, required for dissociation from Ras.
1	Indirect	Indirect	ADJ	JJ	Degree=Pos	_	_	_	_
2	immunofluorescence	immunofluorescence	NOUN	NN	Number=Sing	_	_	_	_
3	shows	show	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
4	that	that	SCONJ	IN	_	_	_	_	_
5	IL	Il	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
6	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
7	2	2	NUM	CD	NumType=Card	_	_	_	_
8	controls	control	NOUN	NNS	Number=Plur	_	_	_	_
9	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
10	cellular	cellular	ADJ	JJ	Degree=Pos	_	_	_	_
11	distribution	distribution	NOUN	NN	Number=Sing	_	_	_	_
12	of	of	ADP	IN	_	_	_	_	_
13	Aiolos	Aiolo	NOUN	NNS	Number=Plur	_	_	_	_
14	and	and	CCONJ	CC	_	_	_	_	_
15	induces	induce	NOUN	NNS	Number=Plur	_	_	_	_
16	it	it	PRON	PRP	Case=Nom|Gender=Neut|Number=Sing|Person=3|PronType=Prs	_	_	_	SpaceAfter=No
17	s	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
18	tyrosine	tyrosine	PRON	PRP	_	_	_	_	_
19	phosphorylation	phosphorylation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
20	,	,	PUNCT	,	_	_	_	_	_
21	required	require	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
22	for	for	ADP	IN	_	_	_	_	_
23	dissociation	dissociation	NOUN	NN	Number=Sing	_	_	_	_
24	from	from	ADP	IN	_	_	_	_	_
25	Ras	Ras	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
26	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2436
# text = We also identified functional Aiolos-binding sites in the Bcl-2 promoter, which are able to activate the luciferase reporter gene.
1	We	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
2	also	also	ADV	RB	_	_	_	_	_
3	identified	identify	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
4	functional	functional	ADJ	JJ	Degree=Pos	_	_	_	_
5	Aiolos	Aiolo	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
6	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
7	binding	bind	VERB	VBG	VerbForm=Ger	_	_	_	_
8	sites	site	NOUN	NNS	Number=Plur	_	_	_	_
9	in	in	ADP	IN	_	_	_	_	_
10	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
11	Bcl	Bcl	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
12	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
13	2	2	NUM	CD	NumType=Card	_	_	_	_
14	promoter	promoter	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
15	,	,	PUNCT	,	_	_	_	_	_
16	which	which	PRON	WDT	PronType=Rel	_	_	_	_
17	are	be	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
18	able	able	ADJ	JJ	Degree=Pos	_	_	_	_
19	to	to	PART	TO	_	_	_	_	_
20	activate	activate	VERB	VB	VerbForm=Inf	_	_	_	_
21	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
22	luciferase	luciferase	NOUN	NN	Number=Sing	_	_	_	_
23	reporter	reporter	NOUN	NN	Number=Sing	_	_	_	_
24	gene	gene	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
25	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2437
# text = Mutation of Aiolos-binding sites within the Bcl-2 promoter inhibits transactivation of the reporter gene luciferase, suggesting direct control of Bcl-2 expression by Aiolos.
1	Mutation	Mutation	NOUN	NN	Number=Sing	_	_	_	_
2	of	of	ADP	IN	_	_	_	_	_
3	Aiolos	Aiolos	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
4	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
5	binding	binding	VERB	VBG	VerbForm=Ger	_	_	_	_
6	sites	site	NOUN	NNS	Number=Plur	_	_	_	_
7	within	within	ADP	IN	_	_	_	_	_
8	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
9	Bcl	Bcl	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
10	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
11	2	2	NUM	CD	NumType=Card	_	_	_	_
12	promoter	promoter	NOUN	NN	Number=Sing	_	_	_	_
13	inhibits	inhibits	NOUN	NNS	Number=Plur	_	_	_	_
14	transactivation	transactivation	NOUN	NN	Number=Sing	_	_	_	_
15	of	of	ADP	IN	_	_	_	_	_
16	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
17	reporter	reporter	NOUN	NN	Number=Sing	_	_	_	_
18	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
19	luciferase	luciferase	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
20	,	,	PUNCT	,	_	_	_	_	_
21	suggesting	suggest	VERB	VBG	VerbForm=Ger	_	_	_	_
22	direct	direct	ADJ	JJ	Degree=Pos	_	_	_	_
23	control	control	NOUN	NN	Number=Sing	_	_	_	_
24	of	of	ADP	IN	_	_	_	_	_
25	Bcl	Bcl	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
26	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
27	2	2	NUM	CD	NumType=Card	_	_	_	_
28	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
29	by	by	ADP	IN	_	_	_	_	_
30	Aiolos	Aiolos	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
31	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2438
# text = Co-transfection experiments confirm that Aiolos induces Bcl-2 expression and prevents apoptosis in IL-2-deprived cells.
1	Co	co	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
2	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
3	transfection	transfection	NOUN	NN	Number=Sing	_	_	_	_
4	experiments	experiment	NOUN	NNS	Number=Plur	_	_	_	_
5	confirm	confirm	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
6	that	that	SCONJ	IN	_	_	_	_	_
7	Aiolos	Aiolos	PROPN	NNP	Number=Sing	_	_	_	_
8	induces	induce	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
9	Bcl	Bcl	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
10	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
11	2	2	NUM	CD	NumType=Card	_	_	_	_
12	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
13	and	and	CCONJ	CC	_	_	_	_	_
14	prevents	prevent	NOUN	NNS	Number=Plur	_	_	_	_
15	apoptosis	apoptosis	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
16	in	in	ADP	IN	_	_	_	_	_
17	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
18	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
19	2	2	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
20	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
21	deprived	deprive	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
22	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
23	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2439
# text = We propose a model for the regulation of Bcl-2 expression via Aiolos.
1	We	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
2	propose	propose	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
3	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
4	model	model	NOUN	NN	Number=Sing	_	_	_	_
5	for	for	ADP	IN	_	_	_	_	_
6	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
7	regulation	regulation	NOUN	NN	Number=Sing	_	_	_	_
8	of	of	ADP	IN	_	_	_	_	_
9	Bcl	Bcl	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
10	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
11	2	2	NUM	CD	NumType=Card	_	_	_	_
12	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
13	via	via	ADP	IN	_	_	_	_	_
14	Aiolos	Aiolos	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
15	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 2440
# text = Document 003003226 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	003003226	003003226	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 2441
# text = Glucocorticoids promote nonphlogistic phagocytosis of apoptotic leukocytes.
1	Glucocorticoids	Glucocorticoid	NOUN	NNS	Number=Plur	_	_	_	_
2	promote	promote	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
3	nonphlogistic	nonphlogistic	ADJ	JJ	Degree=Pos	_	_	_	_
4	phagocytosis	phagocytosis	NOUN	NN	Number=Sing	_	_	_	_
5	of	of	ADP	IN	_	_	_	_	_
6	apoptotic	apoptotic	ADJ	JJ	Degree=Pos	_	_	_	_
7	leukocytes	leukocyte	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
8	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 2442
# text = Phagocyte recognition, uptake, and nonphlogistic degradation of neutrophils and other leukocytes undergoing apoptosis promote the resolution of inflammation.
1	Phagocyte	Phagocyte	NOUN	NN	Number=Sing	_	_	_	_
2	recognition	recognition	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
3	,	,	PUNCT	,	_	_	_	_	_
4	uptake	uptake	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
5	,	,	PUNCT	,	_	_	_	_	_
6	and	and	CCONJ	CC	_	_	_	_	_
7	nonphlogistic	nonphlogistic	ADJ	JJ	Degree=Pos	_	_	_	_
8	degradation	degradation	NOUN	NN	Number=Sing	_	_	_	_
9	of	of	ADP	IN	_	_	_	_	_
10	neutrophils	neutrophil	NOUN	NNS	Number=Plur	_	_	_	_
11	and	and	CCONJ	CC	_	_	_	_	_
12	other	other	ADJ	JJ	Degree=Pos	_	_	_	_
13	leukocytes	leukocyte	NOUN	NNS	Number=Plur	_	_	_	_
14	undergoing	undergo	VERB	VBG	VerbForm=Ger	_	_	_	_
15	apoptosis	apoptosis	PRON	PRP$	Gender=Masc|Number=Sing|Person=3|Poss=Yes|PronType=Prs	_	_	_	_
16	promote	promote	VERB	VB	VerbForm=Inf	_	_	_	_
17	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
18	resolution	resolution	NOUN	NN	Number=Sing	_	_	_	_
19	of	of	ADP	IN	_	_	_	_	_
20	inflammation	inflammation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
21	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2443
# text = This study assessed the effects of anti-inflammatory glucocorticoids on this leukocyte clearance mechanism.
1	This	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
2	study	study	NOUN	NN	Number=Sing	_	_	_	_
3	assessed	assess	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
4	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
5	effects	effect	NOUN	NNS	Number=Plur	_	_	_	_
6	of	of	ADP	IN	_	_	_	_	_
7	anti-inflammatory	anti-inflammatory	ADJ	JJ	Degree=Pos	_	_	_	_
8	glucocorticoids	glucocorticoid	NOUN	NNS	Number=Plur	_	_	_	_
9	on	on	ADP	IN	_	_	_	_	_
10	this	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
11	leukocyte	leukocyte	NOUN	NN	Number=Sing	_	_	_	_
12	clearance	clearance	NOUN	NN	Number=Sing	_	_	_	_
13	mechanism	mechanism	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
14	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2444
# text = Pretreatment of "semimature" 5-day human monocyte-derived macrophages (M phi) for 24 h with methylprednisolone, dexamethasone, and hydrocortisone, but not the nonglucocorticoid steroids aldosterone, estradiol, and progesterone, potentiated phagocytosis of apoptotic neutrophils.
1	Pretreatment	Pretreatment	NOUN	NN	Number=Sing	_	_	_	_
2	of	of	ADP	IN	_	_	_	_	_
3	"	"	PUNCT	``	_	_	_	_	SpaceAfter=No
4	semimature	semimature	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
5	"	"	PUNCT	''	_	_	_	_	_
6	5	5	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
7	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
8	day	day	NOUN	NN	Number=Sing	_	_	_	_
9	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
10	monocyte	monocyte	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
11	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
12	derived	derive	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
13	macrophages	macrophage	NOUN	NNS	Number=Plur	_	_	_	_
14	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
15	M	m	NOUN	NN	Number=Sing	_	_	_	_
16	phi	phi	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
17	)	)	PUNCT	-RRB-	_	_	_	_	_
18	for	for	ADP	IN	_	_	_	_	_
19	24	24	NUM	CD	NumType=Card	_	_	_	_
20	h	h	NOUN	NN	Number=Sing	_	_	_	_
21	with	with	ADP	IN	_	_	_	_	_
22	methylprednisolone	methylprednisolone	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
23	,	,	PUNCT	,	_	_	_	_	_
24	dexamethasone	dexamethasone	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
25	,	,	PUNCT	,	_	_	_	_	_
26	and	and	CCONJ	CC	_	_	_	_	_
27	hydrocortisone	hydrocortisone	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
28	,	,	PUNCT	,	_	_	_	_	_
29	but	but	CCONJ	CC	_	_	_	_	_
30	not	not	ADV	RB	_	_	_	_	_
31	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
32	nonglucocorticoid	nonglucocorticoid	ADJ	JJ	Degree=Pos	_	_	_	_
33	steroids	steroid	NOUN	NNS	Number=Plur	_	_	_	_
34	aldosterone	aldosterone	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
35	,	,	PUNCT	,	_	_	_	_	_
36	estradiol	estradiol	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
37	,	,	PUNCT	,	_	_	_	_	_
38	and	and	CCONJ	CC	_	_	_	_	_
39	progesterone	progesterone	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	SpaceAfter=No
40	,	,	PUNCT	,	_	_	_	_	_
41	potentiated	potentiate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
42	phagocytosis	phagocytosis	NOUN	NN	Number=Sing	_	_	_	_
43	of	of	ADP	IN	_	_	_	_	_
44	apoptotic	apoptotic	ADJ	JJ	Degree=Pos	_	_	_	_
45	neutrophils	neutrophil	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
46	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2445
# text = These effects were specific in that the potentiated phagocytosis of apoptotic neutrophils was completely blocked by the glucocorticoid receptor antagonist RU38486, and glucocorticoids did not promote 5-day M phi ingestion of opsonized erythrocytes.
1	These	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
2	effects	effect	NOUN	NNS	Number=Plur	_	_	_	_
3	were	be	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
4	specific	specific	ADJ	JJ	Degree=Pos	_	_	_	_
5	in	in	ADP	IN	_	_	_	_	_
6	that	that	PRON	DT	Number=Sing|PronType=Dem	_	_	_	_
7	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
8	potentiated	potentiate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
9	phagocytosis	phagocytosis	NOUN	NN	Number=Sing	_	_	_	_
10	of	of	ADP	IN	_	_	_	_	_
11	apoptotic	apoptotic	ADJ	JJ	Degree=Pos	_	_	_	_
12	neutrophils	neutrophil	NOUN	NNS	Number=Plur	_	_	_	_
13	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
14	completely	completely	ADV	RB	_	_	_	_	_
15	blocked	blocked	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
16	by	by	ADP	IN	_	_	_	_	_
17	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
18	glucocorticoid	glucocorticoid	ADJ	JJ	Degree=Pos	_	_	_	_
19	receptor	receptor	NOUN	NN	Number=Sing	_	_	_	_
20	antagonist	antagonist	NOUN	NN	Number=Sing	_	_	_	_
21	RU38486	Ru38486	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
22	,	,	PUNCT	,	_	_	_	_	_
23	and	and	CCONJ	CC	_	_	_	_	_
24	glucocorticoids	glucocorticoid	NOUN	NNS	Number=Plur	_	_	_	_
25	did	do	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
26	not	not	PART	RB	_	_	_	_	_
27	promote	promote	VERB	VB	VerbForm=Inf	_	_	_	_
28	5	5	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
29	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
30	day	day	NOUN	NN	Number=Sing	_	_	_	_
31	M	m	NOUN	NN	Number=Sing	_	_	_	_
32	phi	phi	NOUN	NN	Number=Sing	_	_	_	_
33	ingestion	ingestion	NOUN	NN	Number=Sing	_	_	_	_
34	of	of	ADP	IN	_	_	_	_	_
35	opsonized	opsonize	ADJ	JJ	Degree=Pos	_	_	_	_
36	erythrocytes	erythrocyte	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
37	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2446
# text = Similar glucocorticoid-mediated potentiation was observed with 5-day M phi uptake of alternative apoptotic "targets" (eosinophils and Jurkat T cells) and in uptake of apoptotic neutrophils by alternative phagocytes (human glomerular mesangial cells and murine M phi elicited into the peritoneum or derived from bone marrow).
1	Similar	similar	ADJ	JJ	Degree=Pos	_	_	_	_
2	glucocorticoid	glucocorticoid	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
3	-mediated	-mediated	ADJ	JJ	Degree=Pos	_	_	_	_
4	potentiation	potentiation	NOUN	NN	Number=Sing	_	_	_	_
5	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
6	observed	observe	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
7	with	with	ADP	IN	_	_	_	_	_
8	5	5	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
9	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
10	day	day	NOUN	NN	Number=Sing	_	_	_	_
11	M	be	NOUN	NN	Number=Sing	_	_	_	_
12	phi	phi	NOUN	NN	Number=Sing	_	_	_	_
13	uptake	uptake	NOUN	NN	Number=Sing	_	_	_	_
14	of	of	ADP	IN	_	_	_	_	_
15	alternative	alternative	ADJ	JJ	Degree=Pos	_	_	_	_
16	apoptotic	apoptotic	ADJ	JJ	Degree=Pos	_	_	_	_
17	"	"	PUNCT	``	_	_	_	_	SpaceAfter=No
18	targets	target	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
19	"	"	PUNCT	''	_	_	_	_	_
20	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
21	eosinophils	eosinophil	NOUN	NNS	Number=Plur	_	_	_	_
22	and	and	CCONJ	CC	_	_	_	_	_
23	Jurkat	Jurkat	PROPN	NNP	Number=Sing	_	_	_	_
24	T	t	PROPN	NNP	Number=Sing	_	_	_	_
25	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
26	)	)	PUNCT	-RRB-	_	_	_	_	_
27	and	and	CCONJ	CC	_	_	_	_	_
28	in	in	ADP	IN	_	_	_	_	_
29	uptake	uptake	NOUN	NN	Number=Sing	_	_	_	_
30	of	of	ADP	IN	_	_	_	_	_
31	apoptotic	apoptotic	ADJ	JJ	Degree=Pos	_	_	_	_
32	neutrophils	neutrophil	NOUN	NNS	Number=Plur	_	_	_	_
33	by	by	ADP	IN	_	_	_	_	_
34	alternative	alternative	ADJ	JJ	Degree=Pos	_	_	_	_
35	phagocytes	phagocyte	NOUN	NNS	Number=Plur	_	_	_	_
36	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
37	human	human	AUX	MD	VerbForm=Fin	_	_	_	_
38	glomerular	glomerular	VERB	VB	VerbForm=Inf	_	_	_	_
39	mesangial	mesangial	ADJ	JJ	Degree=Pos	_	_	_	_
40	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
41	and	and	CCONJ	CC	_	_	_	_	_
42	murine	murine	NOUN	NN	Number=Sing	_	_	_	_
43	M	be	NOUN	NN	Number=Sing	_	_	_	_
44	phi	phi	NOUN	NN	Number=Sing	_	_	_	_
45	elicited	elicit	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
46	into	into	ADP	IN	_	_	_	_	_
47	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
48	peritoneum	peritoneum	NOUN	NN	Number=Sing	_	_	_	_
49	or	or	CCONJ	CC	_	_	_	_	_
50	derived	derive	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
51	from	from	ADP	IN	_	_	_	_	_
52	bone	bone	NOUN	NN	Number=Sing	_	_	_	_
53	marrow	marrow	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
54	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
55	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2447
# text = Importantly, methylprednisolone-mediated enhancement of the uptake of apoptotic neutrophils did not trigger the release of the chemokines IL-8 and monocyte chemoattractant protein-1.
1	Importantly	importantly	ADV	RB	_	_	_	_	SpaceAfter=No
2	,	,	PUNCT	,	_	_	_	_	_
3	methylprednisolone	methylprednisolone	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	SpaceAfter=No
4	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
5	mediated	mediate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
6	enhancement	enhancement	NOUN	NN	Number=Sing	_	_	_	_
7	of	of	ADP	IN	_	_	_	_	_
8	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
9	uptake	uptake	NOUN	NN	Number=Sing	_	_	_	_
10	of	of	ADP	IN	_	_	_	_	_
11	apoptotic	apoptotic	ADJ	JJ	Degree=Pos	_	_	_	_
12	neutrophils	neutrophil	NOUN	NNS	Number=Plur	_	_	_	_
13	did	do	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
14	not	not	PART	RB	_	_	_	_	_
15	trigger	trigger	VERB	VB	VerbForm=Inf	_	_	_	_
16	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
17	release	release	NOUN	NN	Number=Sing	_	_	_	_
18	of	of	ADP	IN	_	_	_	_	_
19	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
20	chemokines	chemokine	NOUN	NNS	Number=Plur	_	_	_	_
21	IL	Il	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
22	-	-	SYM	SYM	_	_	_	_	SpaceAfter=No
23	8	8	NUM	CD	NumType=Card	_	_	_	_
24	and	and	CCONJ	CC	_	_	_	_	_
25	monocyte	monocyte	NOUN	NN	Number=Sing	_	_	_	_
26	chemoattractant	chemoattractant	NOUN	NN	Number=Sing	_	_	_	_
27	protein	protein	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
28	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
29	1	1	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
30	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2448
# text = Furthermore, longer-term potentiation by methylprednisolone was observed in maturing human monocyte-derived M phi, with greater increases in 5-day M phi uptake of apoptotic cells being observed the earlier glucocorticoids were added during monocyte maturation into M phi.
1	Furthermore	furthermore	ADV	RB	_	_	_	_	SpaceAfter=No
2	,	,	PUNCT	,	_	_	_	_	_
3	longer	longer	ADJ	JJR	Degree=Cmp	_	_	_	SpaceAfter=No
4	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
5	term	term	NOUN	NN	Number=Sing	_	_	_	_
6	potentiation	potentiation	NOUN	NN	Number=Sing	_	_	_	_
7	by	by	ADP	IN	_	_	_	_	_
8	methylprednisolone	methylprednisolone	NOUN	NN	Number=Sing	_	_	_	_
9	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
10	observed	observe	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
11	in	in	SCONJ	IN	_	_	_	_	_
12	maturing	mature	VERB	VBG	VerbForm=Ger	_	_	_	_
13	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
14	monocyte	monocyte	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
15	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
16	derived	derive	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
17	M	m	NOUN	NN	Number=Sing	_	_	_	_
18	phi	phi	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
19	,	,	PUNCT	,	_	_	_	_	_
20	with	with	ADP	IN	_	_	_	_	_
21	greater	greater	ADJ	JJR	Degree=Cmp	_	_	_	_
22	increases	increase	NOUN	NNS	Number=Plur	_	_	_	_
23	in	in	ADP	IN	_	_	_	_	_
24	5	5	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
25	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
26	day	day	NOUN	NN	Number=Sing	_	_	_	_
27	M	m	NOUN	NN	Number=Sing	_	_	_	_
28	phi	phi	NOUN	NN	Number=Sing	_	_	_	_
29	uptake	uptake	NOUN	NN	Number=Sing	_	_	_	_
30	of	of	ADP	IN	_	_	_	_	_
31	apoptotic	apoptotic	ADJ	JJ	Degree=Pos	_	_	_	_
32	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
33	being	be	AUX	VBG	VerbForm=Ger	_	_	_	_
34	observed	observe	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
35	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
36	earlier	earlier	ADJ	JJR	Degree=Cmp	_	_	_	_
37	glucocorticoids	glucocorticoid	NOUN	NNS	Number=Plur	_	_	_	_
38	were	be	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
39	added	add	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
40	during	during	ADP	IN	_	_	_	_	_
41	monocyte	monocyte	NOUN	NN	Number=Sing	_	_	_	_
42	maturation	maturation	NOUN	NN	Number=Sing	_	_	_	_
43	into	into	ADP	IN	_	_	_	_	_
44	M	m	NOUN	NN	Number=Sing	_	_	_	_
45	phi	phi	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
46	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2449
# text = We conclude that potentiation of nonphlogistic clearance of apoptotic leukocytes by phagocytes is a hitherto unrecognized property of glucocorticoids that has potential implications for therapies aimed at promoting the resolution of inflammatory diseases.
1	We	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
2	conclude	conclude	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
3	that	that	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
4	potentiation	potentiation	NOUN	NN	Number=Sing	_	_	_	_
5	of	of	ADP	IN	_	_	_	_	_
6	nonphlogistic	nonphlogistic	ADJ	JJ	Degree=Pos	_	_	_	_
7	clearance	clearance	NOUN	NN	Number=Sing	_	_	_	_
8	of	of	ADP	IN	_	_	_	_	_
9	apoptotic	apoptotic	ADJ	JJ	Degree=Pos	_	_	_	_
10	leukocytes	leukocyte	NOUN	NNS	Number=Plur	_	_	_	_
11	by	by	ADP	IN	_	_	_	_	_
12	phagocytes	phagocyte	NOUN	NNS	Number=Plur	_	_	_	_
13	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
14	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
15	hitherto	hitherto	NOUN	NN	Number=Sing	_	_	_	_
16	unrecognized	unrecognized	ADJ	JJ	Degree=Pos	_	_	_	_
17	property	property	NOUN	NN	Number=Sing	_	_	_	_
18	of	of	ADP	IN	_	_	_	_	_
19	glucocorticoids	glucocorticoid	NOUN	NNS	Number=Plur	_	_	_	_
20	that	that	PRON	WDT	PronType=Rel	_	_	_	_
21	has	have	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
22	potential	potential	ADJ	JJ	Degree=Pos	_	_	_	_
23	implications	implication	NOUN	NNS	Number=Plur	_	_	_	_
24	for	for	ADP	IN	_	_	_	_	_
25	therapies	therapie	NOUN	NNS	Number=Plur	_	_	_	_
26	aimed	aim	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
27	at	at	SCONJ	IN	_	_	_	_	_
28	promoting	promote	VERB	VBG	VerbForm=Ger	_	_	_	_
29	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
30	resolution	resolution	NOUN	NN	Number=Sing	_	_	_	_
31	of	of	ADP	IN	_	_	_	_	_
32	inflammatory	inflammatory	ADJ	JJ	Degree=Pos	_	_	_	_
33	diseases	disease	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
34	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 2450
# text = Document 003003229 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	003003229	003003229	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 2451
# text = Tumor necrosis factor receptor expression and signal transduction in HIV-1-infected cells.
1	Tumor	tumor	ADP	IN	_	_	_	_	_
2	necrosis	necrosis	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
3	factor	factor	NOUN	NN	Number=Sing	_	_	_	_
4	receptor	receptor	NOUN	NN	Number=Sing	_	_	_	_
5	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
6	and	and	CCONJ	CC	_	_	_	_	_
7	signal	signal	NOUN	NN	Number=Sing	_	_	_	_
8	transduction	transduction	NOUN	NN	Number=Sing	_	_	_	_
9	in	in	ADP	IN	_	_	_	_	_
10	HIV	HIV	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
11	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
12	1	1	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
13	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
14	infected	infect	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
15	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
16	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 2452
# text = OBJECTIVE:
1	OBJECTIVE	objective	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
2	:	:	PUNCT	:	_	_	_	_	_

# sent_id = 2453
# text = To examine the inter-relationship between HIV-1 infection and the cell surface receptors for tumor necrosis factor (TNF)-alpha, an immunoregulatory cytokine that can enhance HIV-1 replication.
1	To	to	PART	TO	_	_	_	_	_
2	examine	examine	VERB	VB	VerbForm=Inf	_	_	_	_
3	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
4	inter-relationship	inter-relationship	NOUN	NN	Number=Sing	_	_	_	_
5	between	between	ADP	IN	_	_	_	_	_
6	HIV	HIV	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
7	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
8	1	1	NUM	CD	NumType=Card	_	_	_	_
9	infection	infection	NOUN	NN	Number=Sing	_	_	_	_
10	and	and	CCONJ	CC	_	_	_	_	_
11	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
12	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
13	surface	surface	NOUN	NN	Number=Sing	_	_	_	_
14	receptors	receptor	NOUN	NNS	Number=Plur	_	_	_	_
15	for	for	ADP	IN	_	_	_	_	_
16	tumor	tumor	NOUN	NN	Number=Sing	_	_	_	_
17	necrosis	necrosis	NOUN	NN	Number=Sing	_	_	_	_
18	factor	factor	NOUN	NN	Number=Sing	_	_	_	_
19	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
20	TNF	TNF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
21	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
22	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
23	alpha	alpha	INTJ	UH	_	_	_	_	SpaceAfter=No
24	,	,	PUNCT	,	_	_	_	_	_
25	an	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
26	immunoregulatory	immunoregulatory	ADJ	JJ	Degree=Pos	_	_	_	_
27	cytokine	cytokine	NOUN	NN	Number=Sing	_	_	_	_
28	that	that	PRON	WDT	PronType=Rel	_	_	_	_
29	can	can	AUX	MD	VerbForm=Fin	_	_	_	_
30	enhance	enhance	VERB	VB	VerbForm=Inf	_	_	_	_
31	HIV	HIV	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
32	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
33	1	1	NUM	CD	NumType=Card	_	_	_	_
34	replication	replication	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
35	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2454
# text = DESIGN: Infected promyelocytic and promonocytic cells were examined because they normally express both types of TNF receptors.
1	DESIGN	Design	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
2	:	:	PUNCT	:	_	_	_	_	_
3	Infected	infect	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
4	promyelocytic	promyelocytic	ADJ	JJ	Degree=Pos	_	_	_	_
5	and	and	CCONJ	CC	_	_	_	_	_
6	promonocytic	promonocytic	ADJ	JJ	Degree=Pos	_	_	_	_
7	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
8	were	be	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
9	examined	examin	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
10	because	because	SCONJ	IN	_	_	_	_	_
11	they	they	PRON	PRP	Case=Nom|Number=Plur|Person=3|PronType=Prs	_	_	_	_
12	normally	normally	ADV	RB	_	_	_	_	_
13	express	express	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
14	both	both	DET	DT	_	_	_	_	_
15	types	type	NOUN	NNS	Number=Plur	_	_	_	_
16	of	of	ADP	IN	_	_	_	_	_
17	TNF	Tnf	NOUN	NN	Number=Sing	_	_	_	_
18	receptors	receptor	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
19	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2455
# text = METHODS: TNF receptor surface expression was determined by specific monoclonal antibody recognition and flow cytometry, and signal transduction was detected by gel shift analysis.
1	METHODS	method	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
2	:	:	PUNCT	:	_	_	_	_	_
3	TNF	Tnf	ADJ	JJ	Degree=Pos	_	_	_	_
4	receptor	receptor	NOUN	NN	Number=Sing	_	_	_	_
5	surface	surface	NOUN	NN	Number=Sing	_	_	_	_
6	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
7	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
8	determined	determine	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
9	by	by	ADP	IN	_	_	_	_	_
10	specific	specific	ADJ	JJ	Degree=Pos	_	_	_	_
11	monoclonal	monoclonal	ADJ	JJ	Degree=Pos	_	_	_	_
12	antibody	antibody	ADJ	JJ	Degree=Pos	_	_	_	_
13	recognition	recognition	NOUN	NN	Number=Sing	_	_	_	_
14	and	and	CCONJ	CC	_	_	_	_	_
15	flow	flow	NOUN	NN	Number=Sing	_	_	_	_
16	cytometry	cytometry	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
17	,	,	PUNCT	,	_	_	_	_	_
18	and	and	CCONJ	CC	_	_	_	_	_
19	signal	signal	ADJ	JJ	Degree=Pos	_	_	_	_
20	transduction	transduction	NOUN	NN	Number=Sing	_	_	_	_
21	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
22	detected	detect	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
23	by	by	ADP	IN	_	_	_	_	_
24	gel	gel	NOUN	NN	Number=Sing	_	_	_	_
25	shift	shift	NOUN	NN	Number=Sing	_	_	_	_
26	analysis	analysis	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
27	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2456
# text = HIV-1 activation and expression was quantitated by reverse transcriptase assay.
1	HIV	Hiv	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
2	-	-	PUNCT	:	_	_	_	_	SpaceAfter=No
3	1	1	NUM	CD	NumType=Card	_	_	_	_
4	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
5	and	and	CCONJ	CC	_	_	_	_	_
6	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
7	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
8	quantitated	quantitate	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
9	by	by	ADP	IN	_	_	_	_	_
10	reverse	reverse	NOUN	NN	Number=Sing	_	_	_	_
11	transcriptase	transcriptase	NOUN	NN	Number=Sing	_	_	_	_
12	assay	assay	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
13	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2457
# text = RESULTS: In the OM-10.1 promyelocytic model of chronic infection, TNF-alpha-induced HIV-1 expression also resulted in a substantial increase in 75 kd TNF receptor (TR75) expression although 55 kD TNF receptor (TR55) levels were not dramatically altered.
1	RESULTS	result	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
2	:	:	PUNCT	:	_	_	_	_	_
3	In	in	ADP	IN	_	_	_	_	_
4	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
5	OM	Om	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
6	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
7	10.1	10.1	NUM	CD	NumType=Card	_	_	_	_
8	promyelocytic	promyelocytic	ADJ	JJ	Degree=Pos	_	_	_	_
9	model	model	NOUN	NN	Number=Sing	_	_	_	_
10	of	of	ADP	IN	_	_	_	_	_
11	chronic	chronic	ADJ	JJ	Degree=Pos	_	_	_	_
12	infection	infection	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
13	,	,	PUNCT	,	_	_	_	_	_
14	TNF	Tnf	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
15	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
16	alpha	alpha	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
17	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
18	induced	induce	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
19	HIV	Hiv	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
20	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
21	1	1	NUM	CD	NumType=Card	_	_	_	_
22	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
23	also	also	ADV	RB	_	_	_	_	_
24	resulted	result	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
25	in	in	ADP	IN	_	_	_	_	_
26	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
27	substantial	substantial	ADJ	JJ	Degree=Pos	_	_	_	_
28	increase	increase	NOUN	NN	Number=Sing	_	_	_	_
29	in	in	ADP	IN	_	_	_	_	_
30	75	75	NUM	CD	NumType=Card	_	_	_	_
31	kd	kd	NOUN	NN	Number=Sing	_	_	_	_
32	TNF	Tnf	NOUN	NN	Number=Sing	_	_	_	_
33	receptor	receptor	NOUN	NN	Number=Sing	_	_	_	_
34	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
35	TR75	TR75	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
36	)	)	PUNCT	-RRB-	_	_	_	_	_
37	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
38	although	although	SCONJ	IN	_	_	_	_	_
39	55	55	NUM	CD	NumType=Card	_	_	_	_
40	kD	kD	PROPN	NNP	Number=Sing	_	_	_	_
41	TNF	TNF	PROPN	NNP	Number=Sing	_	_	_	_
42	receptor	receptor	NOUN	NN	Number=Sing	_	_	_	_
43	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
44	TR55	TR55	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
45	)	)	PUNCT	-RRB-	_	_	_	_	_
46	levels	level	NOUN	NNS	Number=Plur	_	_	_	_
47	were	be	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
48	not	not	PART	RB	_	_	_	_	_
49	dramatically	dramatically	ADV	RB	_	_	_	_	_
50	altered	alter	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	SpaceAfter=No
51	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2458
# text = A series of uninfected parental HL-60 subclones all reduced TR75 surface expression in response to TNF-alpha treatment.
1	A	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
2	series	series	NOUN	NN	Number=Sing	_	_	_	_
3	of	of	ADP	IN	_	_	_	_	_
4	uninfected	uninfected	ADJ	JJ	Degree=Pos	_	_	_	_
5	parental	parental	ADJ	JJ	Degree=Pos	_	_	_	_
6	HL	Hl	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
7	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
8	60	60	NUM	CD	NumType=Card	_	_	_	_
9	subclones	subclone	NOUN	NNS	Number=Plur	_	_	_	_
10	all	all	ADV	RB	_	_	_	_	_
11	reduced	reduce	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
12	TR75	TR75	NUM	CD	NumType=Card	_	_	_	_
13	surface	surface	NOUN	NN	Number=Sing	_	_	_	_
14	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
15	in	in	ADP	IN	_	_	_	_	_
16	response	response	NOUN	NN	Number=Sing	_	_	_	_
17	to	to	ADP	IN	_	_	_	_	_
18	TNF	TNF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
19	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
20	alpha	alpha	NOUN	NN	Number=Sing	_	_	_	_
21	treatment	treatment	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
22	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2459
# text = Enhanced TR75 expression on OM-10.1 cells followed the same TNF-alpha-dose dependency as that observed for HIV-1 production.
1	Enhanced	enhance	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
2	TR75	TR75	NUM	CD	NumType=Card	_	_	_	_
3	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
4	on	on	ADP	IN	_	_	_	_	_
5	OM	OM	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
6	-	-	SYM	SYM	_	_	_	_	SpaceAfter=No
7	10.1	10.1	NUM	CD	NumType=Card	_	_	_	_
8	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
9	followed	follow	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
10	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
11	same	same	ADJ	JJ	Degree=Pos	_	_	_	_
12	TNF	Tnf	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
13	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
14	alpha	alpha	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
15	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
16	dose	dose	NOUN	NN	Number=Sing	_	_	_	_
17	dependency	dependency	NOUN	NN	Number=Sing	_	_	_	_
18	as	as	SCONJ	IN	_	_	_	_	_
19	that	that	PRON	DT	Number=Sing|PronType=Dem	_	_	_	_
20	observed	observe	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
21	for	for	ADP	IN	_	_	_	_	_
22	HIV	HIV	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
23	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
24	1	1	NUM	CD	NumType=Card	_	_	_	_
25	production	production	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
26	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2460
# text = An increase in TR75 expression was also evident during the peak of an acute HIV-1 infection of HL-60 promyelocytes.
1	An	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
2	increase	increase	NOUN	NN	Number=Sing	_	_	_	_
3	in	in	ADP	IN	_	_	_	_	_
4	TR75	TR75	NUM	CD	NumType=Card	_	_	_	_
5	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
6	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
7	also	also	ADV	RB	_	_	_	_	_
8	evident	evident	ADJ	JJ	Degree=Pos	_	_	_	_
9	during	during	ADP	IN	_	_	_	_	_
10	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
11	peak	peak	NOUN	NN	Number=Sing	_	_	_	_
12	of	of	ADP	IN	_	_	_	_	_
13	an	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
14	acute	acute	ADJ	JJ	Degree=Pos	_	_	_	_
15	HIV	Hiv	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
16	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
17	1	1	NUM	CD	NumType=Card	_	_	_	_
18	infection	infection	NOUN	NN	Number=Sing	_	_	_	_
19	of	of	ADP	IN	_	_	_	_	_
20	HL	HL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
21	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
22	60	60	NUM	CD	NumType=Card	_	_	_	_
23	promyelocytes	promyelocyte	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
24	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2461
# text = Although TR55 expression was unaltered during TNF-alpha-induced HIV activation, this receptor was still involved in the viral activation process.
1	Although	although	SCONJ	IN	_	_	_	_	_
2	TR55	TR55	NUM	CD	NumType=Card	_	_	_	_
3	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
4	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
5	unaltered	unaltered	ADJ	JJ	Degree=Pos	_	_	_	_
6	during	during	ADP	IN	_	_	_	_	_
7	TNF	TNF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
8	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
9	alpha	alpha	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
10	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
11	induced	induce	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
12	HIV	Hiv	NOUN	NN	Number=Sing	_	_	_	_
13	activation	activation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
14	,	,	PUNCT	,	_	_	_	_	_
15	this	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
16	receptor	receptor	NOUN	NN	Number=Sing	_	_	_	_
17	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
18	still	still	ADV	RB	_	_	_	_	_
19	involved	involved	ADJ	JJ	Degree=Pos	_	_	_	_
20	in	in	ADP	IN	_	_	_	_	_
21	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
22	viral	viral	ADJ	JJ	Degree=Pos	_	_	_	_
23	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
24	process	process	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
25	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2462
# text = Antibody cross-linking of TR55, in the absence of exogenous TNF-alpha, induced maximal HIV-1 expression, an up-modulation of surface TR75, and nuclear NF-kappa B activity in OM-10.1 cultures.
1	Antibody	Antibody	NOUN	NN	Number=Sing	_	_	_	_
2	cross	cross	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
3	-linking	-linking	VERB	VBG	VerbForm=Ger	_	_	_	_
4	of	of	ADP	IN	_	_	_	_	_
5	TR55	TR55	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
6	,	,	PUNCT	,	_	_	_	_	_
7	in	in	ADP	IN	_	_	_	_	_
8	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
9	absence	absence	NOUN	NN	Number=Sing	_	_	_	_
10	of	of	ADP	IN	_	_	_	_	_
11	exogenous	exogenous	ADJ	JJ	Degree=Pos	_	_	_	_
12	TNF	TNF	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
13	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
14	alpha	alpha	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
15	,	,	PUNCT	,	_	_	_	_	_
16	induced	induce	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
17	maximal	maximal	ADJ	JJ	Degree=Pos	_	_	_	_
18	HIV	Hiv	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
19	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
20	1	1	NUM	CD	NumType=Card	_	_	_	_
21	expression	expression	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
22	,	,	PUNCT	,	_	_	_	_	_
23	an	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
24	up	up	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
25	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
26	modulation	modulation	NOUN	NN	Number=Sing	_	_	_	_
27	of	of	ADP	IN	_	_	_	_	_
28	surface	surface	NOUN	NN	Number=Sing	_	_	_	_
29	TR75	TR75	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
30	,	,	PUNCT	,	_	_	_	_	_
31	and	and	CCONJ	CC	_	_	_	_	_
32	nuclear	nuclear	ADJ	JJ	Degree=Pos	_	_	_	_
33	NF	Nf	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
34	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
35	kappa	kappa	PROPN	NNP	Number=Sing	_	_	_	_
36	B	b	PROPN	NNP	Number=Sing	_	_	_	_
37	activity	activity	NOUN	NN	Number=Sing	_	_	_	_
38	in	in	ADP	IN	_	_	_	_	_
39	OM	OM	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
40	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
41	10.1	10.1	NUM	CD	NumType=Card	_	_	_	_
42	cultures	culture	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
43	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2463
# text = Surprisingly, this was the case even when an antagonistic anti-TR55 antibody was used.
1	Surprisingly	surprisingly	ADV	RB	_	_	_	_	SpaceAfter=No
2	,	,	PUNCT	,	_	_	_	_	_
3	this	this	PRON	DT	Number=Sing|PronType=Dem	_	_	_	_
4	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
5	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
6	case	case	NOUN	NN	Number=Sing	_	_	_	_
7	even	even	ADV	RB	_	_	_	_	_
8	when	when	ADV	WRB	PronType=Int	_	_	_	_
9	an	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
10	antagonistic	antagonistic	ADJ	JJ	Degree=Pos	_	_	_	_
11	anti-TR55	anti-tr55	NOUN	NN	Number=Sing	_	_	_	_
12	antibody	antibody	PRON	NN	Number=Sing	_	_	_	_
13	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
14	used	use	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	SpaceAfter=No
15	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2464
# text = Anti-TR55 antibody cross-linking in chronically infected U1 promonocytic cultures could only partially substitute for TNF-alpha-induced HIV-1 expression.
1	Anti	anti	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
2	-TR55	-TR55	NUM	CD	NumType=Card	_	_	_	_
3	antibody	antibody	NOUN	NN	Number=Sing	_	_	_	_
4	cross	cross	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
5	-linking	-link	VERB	VBG	VerbForm=Ger	_	_	_	_
6	in	in	ADV	RB	_	_	_	_	_
7	chronically	chronically	ADV	RB	_	_	_	_	_
8	infected	infect	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
9	U1	U1	NUM	CD	NumType=Card	_	_	_	_
10	promonocytic	promonocytic	ADJ	JJ	Degree=Pos	_	_	_	_
11	cultures	culture	NOUN	NNS	Number=Plur	_	_	_	_
12	could	could	AUX	MD	VerbForm=Fin	_	_	_	_
13	only	only	ADV	RB	_	_	_	_	_
14	partially	partially	ADV	RB	_	_	_	_	_
15	substitute	substitute	ADV	RB	_	_	_	_	_
16	for	for	ADP	IN	_	_	_	_	_
17	TNF	TNF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
18	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
19	alpha	alpha	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
20	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
21	induced	induce	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
22	HIV	Hiv	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
23	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
24	1	1	NUM	CD	NumType=Card	_	_	_	_
25	expression	expression	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
26	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2465
# text = CONCLUSIONS:
1	CONCLUSIONS	conclusion	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
2	:	:	PUNCT	:	_	_	_	_	_

# sent_id = 2466
# text = Our results demonstrated that HIV-1 infection can selectively influence the surface expression of TNF receptors, potentially influencing its own expression and altering normal immunoregulatory signal transduction.
1	Our	we	PRON	PRP$	Number=Plur|Person=1|Poss=Yes|PronType=Prs	_	_	_	_
2	results	result	NOUN	NNS	Number=Plur	_	_	_	_
3	demonstrated	demonstrate	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
4	that	that	SCONJ	IN	_	_	_	_	_
5	HIV	HIV	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
6	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
7	1	1	NUM	CD	NumType=Card	_	_	_	_
8	infection	infection	NOUN	NN	Number=Sing	_	_	_	_
9	can	can	AUX	MD	VerbForm=Fin	_	_	_	_
10	selectively	selectively	ADV	RB	_	_	_	_	_
11	influence	influence	VERB	VB	VerbForm=Inf	_	_	_	_
12	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
13	surface	surface	NOUN	NN	Number=Sing	_	_	_	_
14	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
15	of	of	ADP	IN	_	_	_	_	_
16	TNF	Tnf	NOUN	NN	Number=Sing	_	_	_	_
17	receptors	receptor	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
18	,	,	PUNCT	,	_	_	_	_	_
19	potentially	potentially	ADV	RB	_	_	_	_	_
20	influencing	influence	VERB	VBG	VerbForm=Ger	_	_	_	_
21	its	its	PRON	PRP$	Gender=Neut|Number=Sing|Person=3|Poss=Yes|PronType=Prs	_	_	_	_
22	own	own	ADJ	JJ	Degree=Pos	_	_	_	_
23	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
24	and	and	CCONJ	CC	_	_	_	_	_
25	altering	alter	VERB	VBG	VerbForm=Ger	_	_	_	_
26	normal	normal	ADJ	JJ	Degree=Pos	_	_	_	_
27	immunoregulatory	immunoregulatory	ADJ	JJ	Degree=Pos	_	_	_	_
28	signal	signal	NOUN	NN	Number=Sing	_	_	_	_
29	transduction	transduction	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
30	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 2467
# text = Document 003003231 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	003003231	003003231	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 2468
# text = A chimeric type II/type I interleukin-1 receptor can mediate interleukin-1 induction of gene expression in T cells.
1	A	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
2	chimeric	chimeric	ADJ	JJ	Degree=Pos	_	_	_	_
3	type	type	NOUN	NN	Number=Sing	_	_	_	_
4	II	ii	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
5	/	/	PUNCT	,	_	_	_	_	SpaceAfter=No
6	type	type	NOUN	NN	Number=Sing	_	_	_	_
7	I	I	PRON	PRP	Case=Nom|Number=Sing|Person=1|PronType=Prs	_	_	_	_
8	interleukin	interleukin	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	SpaceAfter=No
9	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
10	1	1	NUM	CD	NumType=Card	_	_	_	_
11	receptor	receptor	NOUN	NN	Number=Sing	_	_	_	_
12	can	can	AUX	MD	VerbForm=Fin	_	_	_	_
13	mediate	mediate	VERB	VB	VerbForm=Inf	_	_	_	_
14	interleukin	interleukin	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
15	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
16	1	1	NUM	CD	NumType=Card	_	_	_	_
17	induction	induction	NOUN	NN	Number=Sing	_	_	_	_
18	of	of	ADP	IN	_	_	_	_	_
19	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
20	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
21	in	in	ADP	IN	_	_	_	_	_
22	T	t	PROPN	NNP	Number=Sing	_	_	_	_
23	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
24	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 2469
# text = The type I interleukin-1 receptor (IL-1R) is capable of transducing a signal resulting in promoter activation in T cells.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	type	type	NOUN	NN	Number=Sing	_	_	_	_
3	I	I	PRON	PRP	Case=Nom|Number=Sing|Person=1|PronType=Prs	_	_	_	_
4	interleukin	interleukin	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	SpaceAfter=No
5	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
6	1	1	NUM	CD	NumType=Card	_	_	_	_
7	receptor	receptor	NOUN	NN	Number=Sing	_	_	_	_
8	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
9	IL	Il	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
10	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
11	1R	1r	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
12	)	)	PUNCT	-RRB-	_	_	_	_	_
13	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
14	capable	capable	ADJ	JJ	Degree=Pos	_	_	_	_
15	of	of	SCONJ	IN	_	_	_	_	_
16	transducing	transduce	VERB	VBG	VerbForm=Ger	_	_	_	_
17	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
18	signal	signal	NOUN	NN	Number=Sing	_	_	_	_
19	resulting	result	VERB	VBG	VerbForm=Ger	_	_	_	_
20	in	in	ADP	IN	_	_	_	_	_
21	promoter	promoter	NOUN	NN	Number=Sing	_	_	_	_
22	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
23	in	in	ADP	IN	_	_	_	_	_
24	T	t	PROPN	NNP	Number=Sing	_	_	_	_
25	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
26	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2470
# text = This signal transduction is dependent on the cytoplasmic domain, which consists of 213 amino acids.
1	This	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
2	signal	signal	NOUN	NN	Number=Sing	_	_	_	_
3	transduction	transduction	NOUN	NN	Number=Sing	_	_	_	_
4	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
5	dependent	dependent	ADJ	JJ	Degree=Pos	_	_	_	_
6	on	on	ADP	IN	_	_	_	_	_
7	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
8	cytoplasmic	cytoplasmic	ADJ	JJ	Degree=Pos	_	_	_	_
9	domain	domain	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
10	,	,	PUNCT	,	_	_	_	_	_
11	which	which	PRON	WDT	PronType=Rel	_	_	_	_
12	consists	consist	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
13	of	of	ADP	IN	_	_	_	_	_
14	213	213	NUM	CD	NumType=Card	_	_	_	_
15	amino	amino	DET	DT	_	_	_	_	_
16	acids	acid	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
17	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2471
# text = In contrast to the type I receptor, the type II IL-1R has a small cytoplasmic tail, and it is not clear whether this receptor is a signal-transducing or a regulatory molecule.
1	In	in	ADP	IN	_	_	_	_	_
2	contrast	contrast	NOUN	NN	Number=Sing	_	_	_	_
3	to	to	ADP	IN	_	_	_	_	_
4	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
5	type	type	NOUN	NN	Number=Sing	_	_	_	_
6	I	I	PRON	PRP	Case=Nom|Number=Sing|Person=1|PronType=Prs	_	_	_	_
7	receptor	receptor	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
8	,	,	PUNCT	,	_	_	_	_	_
9	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
10	type	type	NOUN	NN	Number=Sing	_	_	_	_
11	II	ii	PROPN	NNP	Number=Sing	_	_	_	_
12	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
13	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
14	1R	1R	PROPN	NNP	Number=Sing	_	_	_	_
15	has	have	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
16	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
17	small	small	ADJ	JJ	Degree=Pos	_	_	_	_
18	cytoplasmic	cytoplasmic	NOUN	NN	Number=Sing	_	_	_	_
19	tail	tail	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
20	,	,	PUNCT	,	_	_	_	_	_
21	and	and	CCONJ	CC	_	_	_	_	_
22	it	it	PRON	PRP	Case=Nom|Gender=Neut|Number=Sing|Person=3|PronType=Prs	_	_	_	_
23	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
24	not	not	PART	RB	_	_	_	_	_
25	clear	clear	ADJ	JJ	Degree=Pos	_	_	_	_
26	whether	whether	SCONJ	IN	_	_	_	_	_
27	this	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
28	receptor	receptor	NOUN	NN	Number=Sing	_	_	_	_
29	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
30	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
31	signal	signal	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
32	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
33	transducing	transducing	NOUN	NN	Number=Sing	_	_	_	_
34	or	or	CCONJ	CC	_	_	_	_	_
35	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
36	regulatory	regulatory	ADJ	JJ	Degree=Pos	_	_	_	_
37	molecule	molecule	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
38	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2472
# text = Here we report that the type II IL-1R does not mediate gene activation in Jurkat cells.
1	Here	here	ADV	RB	PronType=Dem	_	_	_	_
2	we	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
3	report	report	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
4	that	that	SCONJ	IN	_	_	_	_	_
5	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
6	type	type	NOUN	NN	Number=Sing	_	_	_	_
7	II	ii	NUM	CD	NumType=Card	_	_	_	_
8	IL	Il	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
9	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
10	1R	1r	NOUN	NN	Number=Sing	_	_	_	_
11	does	do	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
12	not	not	PART	RB	_	_	_	_	_
13	mediate	mediate	VERB	VB	VerbForm=Inf	_	_	_	_
14	gene	gene	ADJ	JJ	Degree=Pos	_	_	_	_
15	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
16	in	in	ADP	IN	_	_	_	_	_
17	Jurkat	Jurkat	PROPN	NNP	Number=Sing	_	_	_	_
18	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
19	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2473
# text = However, a hybrid receptor composed of the extracellular and transmembrane regions of the human type II interleukin-1 fused to the cytoplasmic domain of the human type I IL-1R was capable of transducing a signal across the membrane resulting in a pattern of gene activation identical to that mediated by the type I IL-1R.
1	However	however	ADV	RB	_	_	_	_	SpaceAfter=No
2	,	,	PUNCT	,	_	_	_	_	_
3	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
4	hybrid	hybrid	NOUN	NN	Number=Sing	_	_	_	_
5	receptor	receptor	NOUN	NN	Number=Sing	_	_	_	_
6	composed	compose	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
7	of	of	ADP	IN	_	_	_	_	_
8	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
9	extracellular	extracellular	ADJ	JJ	Degree=Pos	_	_	_	_
10	and	and	CCONJ	CC	_	_	_	_	_
11	transmembrane	transmembrane	ADJ	JJ	Degree=Pos	_	_	_	_
12	regions	region	NOUN	NNS	Number=Plur	_	_	_	_
13	of	of	ADP	IN	_	_	_	_	_
14	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
15	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
16	type	type	NOUN	NN	Number=Sing	_	_	_	_
17	II	ii	NUM	CD	NumType=Card	_	_	_	_
18	interleukin	interleukin	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
19	-	-	SYM	SYM	_	_	_	_	SpaceAfter=No
20	1	1	NUM	CD	NumType=Card	_	_	_	_
21	fused	fuse	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
22	to	to	ADP	IN	_	_	_	_	_
23	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
24	cytoplasmic	cytoplasmic	ADJ	JJ	Degree=Pos	_	_	_	_
25	domain	domain	NOUN	NN	Number=Sing	_	_	_	_
26	of	of	ADP	IN	_	_	_	_	_
27	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
28	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
29	type	type	NOUN	NN	Number=Sing	_	_	_	_
30	I	I	PRON	PRP	Case=Nom|Number=Sing|Person=1|PronType=Prs	_	_	_	_
31	IL	Il	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
32	-1R	-1R	PROPN	NNP	Number=Sing	_	_	_	_
33	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
34	capable	capable	ADJ	JJ	Degree=Pos	_	_	_	_
35	of	of	SCONJ	IN	_	_	_	_	_
36	transducing	transduce	VERB	VBG	VerbForm=Ger	_	_	_	_
37	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
38	signal	signal	NOUN	NN	Number=Sing	_	_	_	_
39	across	across	ADP	IN	_	_	_	_	_
40	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
41	membrane	membrane	NOUN	NN	Number=Sing	_	_	_	_
42	resulting	result	VERB	VBG	VerbForm=Ger	_	_	_	_
43	in	in	ADP	IN	_	_	_	_	_
44	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
45	pattern	pattern	NOUN	NN	Number=Sing	_	_	_	_
46	of	of	ADP	IN	_	_	_	_	_
47	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
48	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
49	identical	identical	ADJ	JJ	Degree=Pos	_	_	_	_
50	to	to	ADP	IN	_	_	_	_	_
51	that	that	PRON	DT	Number=Sing|PronType=Dem	_	_	_	_
52	mediated	mediate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
53	by	by	ADP	IN	_	_	_	_	_
54	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
55	type	type	NOUN	NN	Number=Sing	_	_	_	_
56	I	I	PRON	PRP	Case=Nom|Number=Sing|Person=1|PronType=Prs	_	_	_	_
57	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
58	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
59	1R	1R	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
60	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2474
# text = Our results indicated that the extracellular domain of the type II IL-1R was capable of functionally interacting with interleukin-1 and transmitting the resulting signal to a heterologous cytoplasmic domain.
1	Our	we	PRON	PRP$	Number=Plur|Person=1|Poss=Yes|PronType=Prs	_	_	_	_
2	results	result	NOUN	NNS	Number=Plur	_	_	_	_
3	indicated	indicate	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
4	that	that	SCONJ	IN	_	_	_	_	_
5	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
6	extracellular	extracellular	ADJ	JJ	Degree=Pos	_	_	_	_
7	domain	domain	NOUN	NN	Number=Sing	_	_	_	_
8	of	of	ADP	IN	_	_	_	_	_
9	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
10	type	type	NOUN	NN	Number=Sing	_	_	_	_
11	II	ii	NUM	CD	NumType=Card	_	_	_	_
12	IL	Il	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
13	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
14	1	1	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
15	R	r	NOUN	NN	Number=Sing	_	_	_	_
16	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
17	capable	capable	ADJ	JJ	Degree=Pos	_	_	_	_
18	of	of	SCONJ	IN	_	_	_	_	_
19	functionally	functionally	ADV	RB	_	_	_	_	_
20	interacting	interact	VERB	VBG	VerbForm=Ger	_	_	_	_
21	with	with	ADP	IN	_	_	_	_	_
22	interleukin	interleukin	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
23	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
24	1	1	NUM	CD	NumType=Card	_	_	_	_
25	and	and	CCONJ	CC	_	_	_	_	_
26	transmitting	transmitt	VERB	VBG	VerbForm=Ger	_	_	_	_
27	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
28	resulting	result	VERB	VBG	VerbForm=Ger	_	_	_	_
29	signal	signal	NOUN	NN	Number=Sing	_	_	_	_
30	to	to	ADP	IN	_	_	_	_	_
31	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
32	heterologous	heterologous	ADJ	JJ	Degree=Pos	_	_	_	_
33	cytoplasmic	cytoplasmic	ADJ	JJ	Degree=Pos	_	_	_	_
34	domain	domain	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
35	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 2475
# text = Document 003003234 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	003003234	003003234	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 2476
# text = Evidence for normal vitamin D receptor messenger ribonucleic acid and genotype in absorptive hypercalciuria.
1	Evidence	evidence	NOUN	NN	Number=Sing	_	_	_	_
2	for	for	ADP	IN	_	_	_	_	_
3	normal	normal	ADJ	JJ	Degree=Pos	_	_	_	_
4	vitamin	vitamin	NOUN	NN	Number=Sing	_	_	_	_
5	D	would	NOUN	NN	Number=Sing	_	_	_	_
6	receptor	receptor	NOUN	NN	Number=Sing	_	_	_	_
7	messenger	messenger	ADV	RBR	_	_	_	_	_
8	ribonucleic	ribonucleic	ADJ	JJ	Degree=Pos	_	_	_	_
9	acid	acid	NOUN	NN	Number=Sing	_	_	_	_
10	and	and	CCONJ	CC	_	_	_	_	_
11	genotype	genotype	NOUN	NN	Number=Sing	_	_	_	_
12	in	in	ADP	IN	_	_	_	_	_
13	absorptive	absorptive	ADJ	JJ	Degree=Pos	_	_	_	_
14	hypercalciuria	hypercalciurion	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
15	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 2477
# text = Absorptive hypercalciuria (a stone-forming condition) is characterized by gut hyperabsorption of calcium, hypercalciuria, and reduced bone density.
1	Absorptive	Absorptive	ADJ	JJ	Degree=Pos	_	_	_	_
2	hypercalciuria	hypercalciuria	NOUN	NN	Number=Sing	_	_	_	_
3	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
4	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
5	stone	stone	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
6	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
7	forming	forming	VERB	VBG	VerbForm=Ger	_	_	_	_
8	condition	condition	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
9	)	)	PUNCT	-RRB-	_	_	_	_	_
10	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
11	characterized	characterize	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
12	by	by	ADP	IN	_	_	_	_	_
13	gut	gut	NOUN	NN	Number=Sing	_	_	_	_
14	hyperabsorption	hyperabsorption	NOUN	NN	Number=Sing	_	_	_	_
15	of	of	ADP	IN	_	_	_	_	_
16	calcium	calcium	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
17	,	,	PUNCT	,	_	_	_	_	_
18	hypercalciuria	hypercalciuria	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
19	,	,	PUNCT	,	_	_	_	_	_
20	and	and	CCONJ	CC	_	_	_	_	_
21	reduced	reduce	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
22	bone	bone	NOUN	NN	Number=Sing	_	_	_	_
23	density	density	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
24	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2478
# text = Inasmuch as these features implicate enhanced calcitriol action in gut and bone, we analyzed the vitamin D receptor (VDR) gene to ascertain whether an abnormality of this gene marks patients with intestinal hyperabsorption of calcium.
1	Inasmuch	Inasmuch	ADV	RB	_	_	_	_	_
2	as	as	SCONJ	IN	_	_	_	_	_
3	these	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
4	features	feature	NOUN	NNS	Number=Plur	_	_	_	_
5	implicate	implicate	VERB	VB	VerbForm=Inf	_	_	_	_
6	enhanced	enhance	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
7	calcitriol	calcitriol	NOUN	NN	Number=Sing	_	_	_	_
8	action	action	NOUN	NN	Number=Sing	_	_	_	_
9	in	in	ADP	IN	_	_	_	_	_
10	gut	gut	NOUN	NN	Number=Sing	_	_	_	_
11	and	and	CCONJ	CC	_	_	_	_	_
12	bone	bone	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
13	,	,	PUNCT	,	_	_	_	_	_
14	we	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
15	analyzed	analyze	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
16	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
17	vitamin	vitamin	NOUN	NN	Number=Sing	_	_	_	_
18	D	d	NOUN	NN	Number=Sing	_	_	_	_
19	receptor	receptor	NOUN	NN	Number=Sing	_	_	_	_
20	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
21	VDR	VDR	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
22	)	)	PUNCT	-RRB-	_	_	_	_	_
23	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
24	to	to	PART	TO	_	_	_	_	_
25	ascertain	ascertain	VERB	VB	VerbForm=Inf	_	_	_	_
26	whether	whether	SCONJ	IN	_	_	_	_	_
27	an	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
28	abnormality	abnormality	NOUN	NN	Number=Sing	_	_	_	_
29	of	of	ADP	IN	_	_	_	_	_
30	this	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
31	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
32	marks	mark	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
33	patients	patient	NOUN	NNS	Number=Plur	_	_	_	_
34	with	with	ADP	IN	_	_	_	_	_
35	intestinal	intestinal	ADJ	JJ	Degree=Pos	_	_	_	_
36	hyperabsorption	hyperabsorption	NOUN	NN	Number=Sing	_	_	_	_
37	of	of	ADP	IN	_	_	_	_	_
38	calcium	calcium	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
39	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2479
# text = We have compared the frequency of a restriction fragment length polymorphism (Bsm I) associated with different alleles of the VDR gene in a group of 33 well characterized absorptive hypercalciuric patients and a group of 36 normal race- and age-matched control subjects.
1	We	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
2	have	have	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
3	compared	compare	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
4	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
5	frequency	frequency	NOUN	NN	Number=Sing	_	_	_	_
6	of	of	ADP	IN	_	_	_	_	_
7	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
8	restriction	restriction	NOUN	NN	Number=Sing	_	_	_	_
9	fragment	fragment	NOUN	NN	Number=Sing	_	_	_	_
10	length	length	NOUN	NN	Number=Sing	_	_	_	_
11	polymorphism	polymorphism	NOUN	NN	Number=Sing	_	_	_	_
12	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
13	Bsm	Bsm	PROPN	NNP	Number=Sing	_	_	_	_
14	I	I	PRON	PRP	Case=Nom|Number=Sing|Person=1|PronType=Prs	_	_	_	SpaceAfter=No
15	)	)	PUNCT	-RRB-	_	_	_	_	_
16	associated	associate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
17	with	with	ADP	IN	_	_	_	_	_
18	different	different	ADJ	JJ	Degree=Pos	_	_	_	_
19	alleles	allele	NOUN	NNS	Number=Plur	_	_	_	_
20	of	of	ADP	IN	_	_	_	_	_
21	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
22	VDR	VDR	PROPN	NNP	Number=Sing	_	_	_	_
23	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
24	in	in	ADP	IN	_	_	_	_	_
25	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
26	group	group	NOUN	NN	Number=Sing	_	_	_	_
27	of	of	ADP	IN	_	_	_	_	_
28	33	33	NUM	CD	NumType=Card	_	_	_	_
29	well	well	ADV	RB	Degree=Pos	_	_	_	_
30	characterized	characterize	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
31	absorptive	absorptive	ADJ	JJ	Degree=Pos	_	_	_	_
32	hypercalciuric	hypercalciuric	ADJ	JJ	Degree=Pos	_	_	_	_
33	patients	patient	NOUN	NNS	Number=Plur	_	_	_	_
34	and	and	CCONJ	CC	_	_	_	_	_
35	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
36	group	group	NOUN	NN	Number=Sing	_	_	_	_
37	of	of	ADP	IN	_	_	_	_	_
38	36	36	NUM	CD	NumType=Card	_	_	_	_
39	normal	normal	ADJ	JJ	Degree=Pos	_	_	_	_
40	race	race	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
41	-	-	PUNCT	,	_	_	_	_	_
42	and	and	CCONJ	CC	_	_	_	_	_
43	age	age	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
44	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
45	matched	match	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
46	control	control	NOUN	NN	Number=Sing	_	_	_	_
47	subjects	subject	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
48	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2480
# text = There was no difference between the distribution of the VDR alleles in the patient population when compared with the normal population.
1	There	there	PRON	EX	_	_	_	_	_
2	was	be	VERB	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
3	no	no	DET	DT	_	_	_	_	_
4	difference	difference	NOUN	NN	Number=Sing	_	_	_	_
5	between	between	ADP	IN	_	_	_	_	_
6	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
7	distribution	distribution	NOUN	NN	Number=Sing	_	_	_	_
8	of	of	ADP	IN	_	_	_	_	_
9	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
10	VDR	Vdr	ADJ	JJR	Degree=Cmp	_	_	_	_
11	alleles	allele	NOUN	NNS	Number=Plur	_	_	_	_
12	in	in	ADP	IN	_	_	_	_	_
13	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
14	patient	patient	ADJ	JJ	Degree=Pos	_	_	_	_
15	population	population	NOUN	NN	Number=Sing	_	_	_	_
16	when	when	ADV	WRB	PronType=Int	_	_	_	_
17	compared	compare	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
18	with	with	ADP	IN	_	_	_	_	_
19	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
20	normal	normal	ADJ	JJ	Degree=Pos	_	_	_	_
21	population	population	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
22	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2481
# text = The coding region of VDR messenger RNA was also normal, as determined by both DNA sequence analysis and chemical mismatch cleavage analysis of copy DNA from 11 index absorptive hypercalciuric patients.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	coding	coding	NOUN	NN	Number=Sing	_	_	_	_
3	region	region	NOUN	NN	Number=Sing	_	_	_	_
4	of	of	ADP	IN	_	_	_	_	_
5	VDR	VDR	PROPN	NNP	Number=Sing	_	_	_	_
6	messenger	messenger	PROPN	NNP	Number=Sing	_	_	_	_
7	RNA	RNA	PROPN	NNP	Number=Sing	_	_	_	_
8	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
9	also	also	ADV	RB	_	_	_	_	_
10	normal	normal	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
11	,	,	PUNCT	,	_	_	_	_	_
12	as	as	SCONJ	IN	_	_	_	_	_
13	determined	determine	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
14	by	by	ADP	IN	_	_	_	_	_
15	both	both	DET	DT	_	_	_	_	_
16	DNA	dna	NOUN	NN	Number=Sing	_	_	_	_
17	sequence	sequence	NOUN	NN	Number=Sing	_	_	_	_
18	analysis	analysis	NOUN	NN	Number=Sing	_	_	_	_
19	and	and	CCONJ	CC	_	_	_	_	_
20	chemical	chemical	ADJ	JJ	Degree=Pos	_	_	_	_
21	mismatch	mismatch	NOUN	NN	Number=Sing	_	_	_	_
22	cleavage	cleavage	NOUN	NN	Number=Sing	_	_	_	_
23	analysis	analysis	NOUN	NN	Number=Sing	_	_	_	_
24	of	of	ADP	IN	_	_	_	_	_
25	copy	copy	NOUN	NN	Number=Sing	_	_	_	_
26	DNA	dna	NOUN	NN	Number=Sing	_	_	_	_
27	from	from	ADP	IN	_	_	_	_	_
28	11	11	NUM	CD	NumType=Card	_	_	_	_
29	index	index	NOUN	NN	Number=Sing	_	_	_	_
30	absorptive	absorptive	ADJ	JJ	Degree=Pos	_	_	_	_
31	hypercalciuric	hypercalciuric	ADJ	JJ	Degree=Pos	_	_	_	_
32	patients	patient	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
33	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2482
# text = On the basis of these results, we propose that the enhanced intestinal calcium absorption invariably seen in absorptive hypercalciuria and attendant symptoms of this disorder are not attributable to mutations of the VDR and are not linked to a common VDR genotype.
1	On	on	ADP	IN	_	_	_	_	_
2	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
3	basis	basis	NOUN	NN	Number=Sing	_	_	_	_
4	of	of	ADP	IN	_	_	_	_	_
5	these	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
6	results	result	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
7	,	,	PUNCT	,	_	_	_	_	_
8	we	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
9	propose	propose	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
10	that	that	SCONJ	IN	_	_	_	_	_
11	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
12	enhanced	enhance	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
13	intestinal	intestinal	ADJ	JJ	Degree=Pos	_	_	_	_
14	calcium	calcium	NOUN	NN	Number=Sing	_	_	_	_
15	absorption	absorption	NOUN	NN	Number=Sing	_	_	_	_
16	invariably	invariably	ADV	RB	_	_	_	_	_
17	seen	see	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
18	in	in	ADP	IN	_	_	_	_	_
19	absorptive	absorptive	ADJ	JJ	Degree=Pos	_	_	_	_
20	hypercalciuria	hypercalciurion	NOUN	NNS	Number=Plur	_	_	_	_
21	and	and	CCONJ	CC	_	_	_	_	_
22	attendant	attendant	ADJ	JJ	Degree=Pos	_	_	_	_
23	symptoms	symptom	NOUN	NNS	Number=Plur	_	_	_	_
24	of	of	ADP	IN	_	_	_	_	_
25	this	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
26	disorder	disorder	NOUN	NN	Number=Sing	_	_	_	_
27	are	be	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
28	not	not	PART	RB	_	_	_	_	_
29	attributable	attributable	ADJ	JJ	Degree=Pos	_	_	_	_
30	to	to	ADP	IN	_	_	_	_	_
31	mutations	mutation	NOUN	NNS	Number=Plur	_	_	_	_
32	of	of	ADP	IN	_	_	_	_	_
33	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
34	VDR	VDR	PROPN	NNP	Number=Sing	_	_	_	_
35	and	and	CCONJ	CC	_	_	_	_	_
36	are	be	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
37	not	not	PART	RB	_	_	_	_	_
38	linked	link	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
39	to	to	ADP	IN	_	_	_	_	_
40	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
41	common	common	ADJ	JJ	Degree=Pos	_	_	_	_
42	VDR	Vdr	NOUN	NN	Number=Sing	_	_	_	_
43	genotype	genotype	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
44	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 2483
# text = Document 003003239 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	003003239	003003239	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 2484
# text = Abnormalities of cyclic adenosine monophosphate signaling in platelets from untreated patients with bipolar disorder.
1	Abnormalities	Abnormality	NOUN	NNS	Number=Plur	_	_	_	_
2	of	of	ADP	IN	_	_	_	_	_
3	cyclic	cyclic	ADJ	JJ	Degree=Pos	_	_	_	_
4	adenosine	adenosine	NOUN	NN	Number=Sing	_	_	_	_
5	monophosphate	monophosphate	NOUN	NN	Number=Sing	_	_	_	_
6	signaling	signale	VERB	VBG	VerbForm=Ger	_	_	_	_
7	in	in	ADP	IN	_	_	_	_	_
8	platelets	platelet	NOUN	NNS	Number=Plur	_	_	_	_
9	from	from	ADP	IN	_	_	_	_	_
10	untreated	untreated	ADJ	JJ	Degree=Pos	_	_	_	_
11	patients	patient	NOUN	NNS	Number=Plur	_	_	_	_
12	with	with	ADP	IN	_	_	_	_	_
13	bipolar	bipolar	ADJ	JJ	Degree=Pos	_	_	_	_
14	disorder	disorder	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
15	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 2485
# text = BACKGROUND: Abnormalities in the cyclic adenosine monophosphate (cAMP)-dependent phosphorylation system have been recently reported in patients with bipolar disorder.
1	BACKGROUND	background	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
2	:	:	PUNCT	:	_	_	_	_	_
3	Abnormalities	Abnormality	NOUN	NNS	Number=Plur	_	_	_	_
4	in	in	ADP	IN	_	_	_	_	_
5	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
6	cyclic	cyclic	ADJ	JJ	Degree=Pos	_	_	_	_
7	adenosine	adenosine	NOUN	NN	Number=Sing	_	_	_	_
8	monophosphate	monophosphate	NOUN	NN	Number=Sing	_	_	_	_
9	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
10	cAMP	camp	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
11	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
12	-	-	PUNCT	:	_	_	_	_	SpaceAfter=No
13	dependent	dependent	ADJ	JJ	Degree=Pos	_	_	_	_
14	phosphorylation	phosphorylation	NOUN	NN	Number=Sing	_	_	_	_
15	system	system	NOUN	NN	Number=Sing	_	_	_	_
16	have	have	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
17	been	be	AUX	VBN	Tense=Past|VerbForm=Part	_	_	_	_
18	recently	recently	ADV	RB	_	_	_	_	_
19	reported	report	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
20	in	in	ADP	IN	_	_	_	_	_
21	patients	patient	NOUN	NN	Number=Sing	_	_	_	_
22	with	with	ADP	IN	_	_	_	_	_
23	bipolar	bipolar	ADJ	JJ	Degree=Pos	_	_	_	_
24	disorder	disorder	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
25	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2486
# text = We evaluated the immunoreactivity of the regulatory and catalytic subunits of cAMP-dependent protein kinase (protein kinase A) and 1 of its substrates, Rap1, in platelets from untreated euthymic, manic, and depressed patients with bipolar disorder and healthy subjects.
1	We	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
2	evaluated	evaluate	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
3	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
4	immunoreactivity	immunoreactivity	NOUN	NN	Number=Sing	_	_	_	_
5	of	of	ADP	IN	_	_	_	_	_
6	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
7	regulatory	regulatory	ADJ	JJ	Degree=Pos	_	_	_	_
8	and	and	CCONJ	CC	_	_	_	_	_
9	catalytic	catalytic	ADJ	JJ	Degree=Pos	_	_	_	_
10	subunits	subunit	NOUN	NNS	Number=Plur	_	_	_	_
11	of	of	ADP	IN	_	_	_	_	_
12	cAMP	camp	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
13	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
14	dependent	dependent	ADJ	JJ	Degree=Pos	_	_	_	_
15	protein	protein	NOUN	NN	Number=Sing	_	_	_	_
16	kinase	kinase	NOUN	NN	Number=Sing	_	_	_	_
17	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
18	protein	protein	NOUN	NN	Number=Sing	_	_	_	_
19	kinase	kinase	NOUN	NN	Number=Sing	_	_	_	_
20	A	a	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
21	)	)	PUNCT	-RRB-	_	_	_	_	_
22	and	and	CCONJ	CC	_	_	_	_	_
23	1	1	NUM	CD	NumType=Card	_	_	_	_
24	of	of	ADP	IN	_	_	_	_	_
25	its	its	PRON	PRP$	Gender=Neut|Number=Sing|Person=3|Poss=Yes|PronType=Prs	_	_	_	_
26	substrates	substrate	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
27	,	,	PUNCT	,	_	_	_	_	_
28	Rap1	Rap1	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
29	,	,	PUNCT	,	_	_	_	_	_
30	in	in	ADP	IN	_	_	_	_	_
31	platelets	platelet	NOUN	NNS	Number=Plur	_	_	_	_
32	from	from	ADP	IN	_	_	_	_	_
33	untreated	untreated	ADJ	JJ	Degree=Pos	_	_	_	_
34	euthymic	euthymic	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
35	,	,	PUNCT	,	_	_	_	_	_
36	manic	manic	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
37	,	,	PUNCT	,	_	_	_	_	_
38	and	and	CCONJ	CC	_	_	_	_	_
39	depressed	depress	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
40	patients	patient	NOUN	NNS	Number=Plur	_	_	_	_
41	with	with	ADP	IN	_	_	_	_	_
42	bipolar	bipolar	ADJ	JJ	Degree=Pos	_	_	_	_
43	disorder	disorder	NOUN	NN	Number=Sing	_	_	_	_
44	and	and	CCONJ	CC	_	_	_	_	_
45	healthy	healthy	ADJ	JJ	Degree=Pos	_	_	_	_
46	subjects	subjects	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
47	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2487
# text = METHODS: Platelets were collected from 112 drug-free patients with bipolar disorder (52 euthymic, 29 depressed, and 31 manic) and 62 healthy subjects.
1	METHODS	method	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
2	:	:	PUNCT	:	_	_	_	_	_
3	Platelets	Platelet	NOUN	NNS	Number=Plur	_	_	_	_
4	were	be	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
5	collected	collect	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
6	from	from	ADP	IN	_	_	_	_	_
7	112	112	NUM	CD	NumType=Card	_	_	_	_
8	drug	drug	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
9	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
10	free	free	ADJ	JJ	Degree=Pos	_	_	_	_
11	patients	patient	NOUN	NN	Number=Sing	_	_	_	_
12	with	with	ADP	IN	_	_	_	_	_
13	bipolar	bipolar	ADJ	JJ	Degree=Pos	_	_	_	_
14	disorder	disorder	NOUN	NN	Number=Sing	_	_	_	_
15	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
16	52	52	NUM	CD	NumType=Card	_	_	_	_
17	euthymic	euthymic	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
18	,	,	PUNCT	,	_	_	_	_	_
19	29	29	NUM	CD	NumType=Card	_	_	_	_
20	depressed	depressed	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	SpaceAfter=No
21	,	,	PUNCT	,	_	_	_	_	_
22	and	and	CCONJ	CC	_	_	_	_	_
23	31	31	NUM	CD	NumType=Card	_	_	_	_
24	manic	manic	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
25	)	)	PUNCT	-RRB-	_	_	_	_	_
26	and	and	CCONJ	CC	_	_	_	_	_
27	62	62	NUM	CD	NumType=Card	_	_	_	_
28	healthy	healthy	ADJ	JJ	Degree=Pos	_	_	_	_
29	subjects	subjects	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
30	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2488
# text = The levels of cAMP-dependent protein kinase and Rap1 were assessed by Western blot analysis, immunostaining, and computer-assisted imaging.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	levels	level	NOUN	NNS	Number=Plur	_	_	_	_
3	of	of	ADP	IN	_	_	_	_	_
4	cAMP	camp	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
5	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
6	dependent	dependent	ADJ	JJ	Degree=Pos	_	_	_	_
7	protein	protein	NOUN	NN	Number=Sing	_	_	_	_
8	kinase	kinase	NOUN	NN	Number=Sing	_	_	_	_
9	and	and	CCONJ	CC	_	_	_	_	_
10	Rap1	rap1	PROPN	NNP	Number=Sing	_	_	_	_
11	were	be	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
12	assessed	assess	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
13	by	by	ADP	IN	_	_	_	_	_
14	Western	western	ADJ	JJ	Degree=Pos	_	_	_	_
15	blot	blot	NOUN	NN	Number=Sing	_	_	_	_
16	analysis	analysis	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
17	,	,	PUNCT	,	_	_	_	_	_
18	immunostaining	immunostain	VERB	VBG	VerbForm=Ger	_	_	_	SpaceAfter=No
19	,	,	PUNCT	,	_	_	_	_	_
20	and	and	CCONJ	CC	_	_	_	_	_
21	computer	computer	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
22	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
23	assisted	assist	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
24	imaging	imaging	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
25	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2489
# text = RESULTS: The immunolabeling of the catalytic subunit of cAMP-dependent protein kinase was significantly different among groups (P<.001), with higher values in untreated depressed and manic patients with bipolar disorder compared with untreated euthymic patients with bipolar disorder and healthy subjects.
1	RESULTS	result	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
2	:	:	PUNCT	:	_	_	_	_	_
3	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
4	immunolabeling	immunolabeling	NOUN	NN	Number=Sing	_	_	_	_
5	of	of	ADP	IN	_	_	_	_	_
6	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
7	catalytic	catalytic	ADJ	JJ	Degree=Pos	_	_	_	_
8	subunit	subunit	NOUN	NN	Number=Sing	_	_	_	_
9	of	of	ADP	IN	_	_	_	_	_
10	cAMP	camp	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
11	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
12	dependent	dependent	ADJ	JJ	Degree=Pos	_	_	_	_
13	protein	protein	NOUN	NN	Number=Sing	_	_	_	_
14	kinase	kinase	NOUN	NN	Number=Sing	_	_	_	_
15	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
16	significantly	significantly	ADV	RB	_	_	_	_	_
17	different	different	ADJ	JJ	Degree=Pos	_	_	_	_
18	among	among	ADP	IN	_	_	_	_	_
19	groups	group	NOUN	NNS	Number=Plur	_	_	_	_
20	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
21	P	p	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
22	<	<	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
23	.001	.001	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
24	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
25	,	,	PUNCT	,	_	_	_	_	_
26	with	with	ADP	IN	_	_	_	_	_
27	higher	higher	ADJ	JJR	Degree=Cmp	_	_	_	_
28	values	value	NOUN	NNS	Number=Plur	_	_	_	_
29	in	in	ADP	IN	_	_	_	_	_
30	untreated	untreated	ADJ	JJ	Degree=Pos	_	_	_	_
31	depressed	depressed	ADJ	JJ	Degree=Pos	_	_	_	_
32	and	and	CCONJ	CC	_	_	_	_	_
33	manic	manic	ADJ	JJ	Degree=Pos	_	_	_	_
34	patients	patient	NOUN	NNS	Number=Plur	_	_	_	_
35	with	with	ADP	IN	_	_	_	_	_
36	bipolar	bipolar	ADJ	JJ	Degree=Pos	_	_	_	_
37	disorder	disorder	NOUN	NN	Number=Sing	_	_	_	_
38	compared	compare	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
39	with	with	ADP	IN	_	_	_	_	_
40	untreated	untreated	ADJ	JJ	Degree=Pos	_	_	_	_
41	euthymic	euthymic	ADJ	JJ	Degree=Pos	_	_	_	_
42	patients	patient	NOUN	NNS	Number=Plur	_	_	_	_
43	with	with	ADP	IN	_	_	_	_	_
44	bipolar	bipolar	ADJ	JJ	Degree=Pos	_	_	_	_
45	disorder	disorder	NOUN	NN	Number=Sing	_	_	_	_
46	and	and	CCONJ	CC	_	_	_	_	_
47	healthy	healthy	ADJ	JJ	Degree=Pos	_	_	_	_
48	subjects	subjects	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
49	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2490
# text = No significant differences were found in the immunolabeling of the regulatory subunits (type I and type II) of cAMP-dependent protein kinase.
1	No	no	DET	DT	_	_	_	_	_
2	significant	significant	ADJ	JJ	Degree=Pos	_	_	_	_
3	differences	difference	NOUN	NNS	Number=Plur	_	_	_	_
4	were	be	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
5	found	find	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
6	in	in	ADP	IN	_	_	_	_	_
7	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
8	immunolabeling	immunolabeling	NOUN	NN	Number=Sing	_	_	_	_
9	of	of	ADP	IN	_	_	_	_	_
10	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
11	regulatory	regulatory	ADJ	JJ	Degree=Pos	_	_	_	_
12	subunits	subunit	NOUN	NNS	Number=Plur	_	_	_	_
13	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
14	type	type	INTJ	UH	_	_	_	_	_
15	I	I	PRON	PRP	Case=Nom|Number=Sing|Person=1|PronType=Prs	_	_	_	_
16	and	and	CCONJ	CC	_	_	_	_	_
17	type	type	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
18	II	ii	X	LS	_	_	_	_	SpaceAfter=No
19	)	)	PUNCT	-RRB-	_	_	_	_	_
20	of	of	ADP	IN	_	_	_	_	_
21	cAMP	camp	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
22	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
23	dependent	dependent	ADJ	JJ	Degree=Pos	_	_	_	_
24	protein	protein	NOUN	NN	Number=Sing	_	_	_	_
25	kinase	kinase	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
26	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2491
# text = The immunolabeling of Rap1 was significantly higher (P<.001) in untreated euthymic, depressed, and manic patients than in healthy persons.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	immunolabeling	immunolabeling	NOUN	NN	Number=Sing	_	_	_	_
3	of	of	ADP	IN	_	_	_	_	_
4	Rap1	Rap1	PROPN	NNP	Number=Sing	_	_	_	_
5	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
6	significantly	significantly	ADV	RB	_	_	_	_	_
7	higher	higher	ADJ	JJR	Degree=Cmp	_	_	_	_
8	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
9	P	p	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
10	<	<	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
11	.001	.001	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
12	)	)	PUNCT	-RRB-	_	_	_	_	_
13	in	in	ADP	IN	_	_	_	_	_
14	untreated	untreated	ADJ	JJ	Degree=Pos	_	_	_	_
15	euthymic	euthymic	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
16	,	,	PUNCT	,	_	_	_	_	_
17	depressed	depress	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	SpaceAfter=No
18	,	,	PUNCT	,	_	_	_	_	_
19	and	and	CCONJ	CC	_	_	_	_	_
20	manic	manic	ADJ	JJ	Degree=Pos	_	_	_	_
21	patients	patient	NOUN	NNS	Number=Plur	_	_	_	_
22	than	than	ADP	IN	_	_	_	_	_
23	in	in	ADP	IN	_	_	_	_	_
24	healthy	healthy	ADJ	JJ	Degree=Pos	_	_	_	_
25	persons	person	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
26	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2492
# text = CONCLUSIONS: Levels of Rap1 and the catalytic subunit of cAMP-dependent protein kinase are altered in the platelets of bipolar patients.
1	CONCLUSIONS	conclusion	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
2	:	:	PUNCT	:	_	_	_	_	_
3	Levels	level	NOUN	NNS	Number=Plur	_	_	_	_
4	of	of	ADP	IN	_	_	_	_	_
5	Rap1	Rap1	PROPN	NNP	Number=Sing	_	_	_	_
6	and	and	CCONJ	CC	_	_	_	_	_
7	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
8	catalytic	catalytic	ADJ	JJ	Degree=Pos	_	_	_	_
9	subunit	subunit	NOUN	NN	Number=Sing	_	_	_	_
10	of	of	ADP	IN	_	_	_	_	_
11	cAMP	camp	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
12	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
13	dependent	dependent	ADJ	JJ	Degree=Pos	_	_	_	_
14	protein	protein	NOUN	NN	Number=Sing	_	_	_	_
15	kinase	kinase	NOUN	NN	Number=Sing	_	_	_	_
16	are	be	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
17	altered	alter	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
18	in	in	ADP	IN	_	_	_	_	_
19	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
20	platelets	platelet	NOUN	NNS	Number=Plur	_	_	_	_
21	of	of	ADP	IN	_	_	_	_	_
22	bipolar	bipolar	ADJ	JJ	Degree=Pos	_	_	_	_
23	patients	patient	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
24	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2493
# text = These findings may provide clues toward understanding the involvement of cAMP signaling in the pathogenesis of bipolar disorder.
1	These	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
2	findings	finding	NOUN	NNS	Number=Plur	_	_	_	_
3	may	may	AUX	MD	VerbForm=Fin	_	_	_	_
4	provide	provide	VERB	VB	VerbForm=Inf	_	_	_	_
5	clues	clue	NOUN	NNS	Number=Plur	_	_	_	_
6	toward	toward	SCONJ	IN	_	_	_	_	_
7	understanding	understande	VERB	VBG	VerbForm=Ger	_	_	_	_
8	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
9	involvement	involvement	NOUN	NN	Number=Sing	_	_	_	_
10	of	of	ADP	IN	_	_	_	_	_
11	cAMP	camp	NOUN	NN	Number=Sing	_	_	_	_
12	signaling	signal	NOUN	NN	Number=Sing	_	_	_	_
13	in	in	ADP	IN	_	_	_	_	_
14	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
15	pathogenesis	pathogenesis	NOUN	NN	Number=Sing	_	_	_	_
16	of	of	ADP	IN	_	_	_	_	_
17	bipolar	bipolar	ADJ	JJ	Degree=Pos	_	_	_	_
18	disorder	disorder	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
19	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 2494
# text = Document 003003242 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	003003242	003003242	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 2495
# text = Phorbol ester-induced mononuclear cell differentiation is blocked by the mitogen-activated protein kinase kinase (MEK) inhibitor PD98059.
1	Phorbol	Phorbol	NOUN	NN	Number=Sing	_	_	_	_
2	ester	ester	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
3	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
4	induced	induce	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
5	mononuclear	mononuclear	NOUN	NN	Number=Sing	_	_	_	_
6	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
7	differentiation	differentiation	NOUN	NN	Number=Sing	_	_	_	_
8	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
9	blocked	block	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
10	by	by	ADP	IN	_	_	_	_	_
11	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
12	mitogen	mitogen	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
13	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
14	activated	activate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
15	protein	protein	NOUN	NN	Number=Sing	_	_	_	_
16	kinase	kinase	NOUN	NN	Number=Sing	_	_	_	_
17	kinase	kinase	NOUN	NN	Number=Sing	_	_	_	_
18	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
19	MEK	MEK	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
20	)	)	PUNCT	-RRB-	_	_	_	_	_
21	inhibitor	inhibitor	NOUN	NN	Number=Sing	_	_	_	_
22	PD98059	Pd98059	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
23	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 2496
# text = The purpose of this study was to evaluate whether the mitogen-activated protein kinase (MAPK) signaling pathway contributes to 12-O-tetradecanoylphorbol-13-acetate (TPA)-induced mononuclear differentiation in the human myeloblastic leukemia ML-1 cells.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	purpose	purpose	NOUN	NN	Number=Sing	_	_	_	_
3	of	of	ADP	IN	_	_	_	_	_
4	this	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
5	study	study	NOUN	NN	Number=Sing	_	_	_	_
6	was	be	VERB	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
7	to	to	PART	TO	_	_	_	_	_
8	evaluate	evaluate	VERB	VB	VerbForm=Inf	_	_	_	_
9	whether	whether	SCONJ	IN	_	_	_	_	_
10	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
11	mitogen	mitogen	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
12	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
13	activated	activate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
14	protein	protein	NOUN	NN	Number=Sing	_	_	_	_
15	kinase	kinase	NOUN	NN	Number=Sing	_	_	_	_
16	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
17	MAPK	MAPK	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
18	)	)	PUNCT	-RRB-	_	_	_	_	_
19	signaling	signaling	NOUN	NN	Number=Sing	_	_	_	_
20	pathway	pathway	NOUN	NN	Number=Sing	_	_	_	_
21	contributes	contribute	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
22	to	to	PART	TO	_	_	_	_	_
23	12-	12-	PUNCT	,	_	_	_	_	SpaceAfter=No
24	O	o	INTJ	UH	_	_	_	_	SpaceAfter=No
25	-tetradecanoylphorbol	-tetradecanoylphorbol	INTJ	UH	_	_	_	_	SpaceAfter=No
26	-13	-13	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
27	-acetate	-acetate	NOUN	NN	Number=Sing	_	_	_	_
28	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
29	TPA	TPA	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
30	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
31	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
32	induced	induce	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
33	mononuclear	mononuclear	NOUN	NN	Number=Sing	_	_	_	_
34	differentiation	differentiation	NOUN	NN	Number=Sing	_	_	_	_
35	in	in	ADP	IN	_	_	_	_	_
36	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
37	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
38	myeloblastic	myeloblastic	ADJ	JJ	Degree=Pos	_	_	_	_
39	leukemia	leukemia	NOUN	NN	Number=Sing	_	_	_	_
40	ML	Ml	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
41	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
42	1	1	NUM	CD	NumType=Card	_	_	_	_
43	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
44	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2497
# text = Upon TPA treatment, the activity of ERK1 and ERK2 rapidly increased, with maximal induction between 1 and 3 h, while ERK2 protein levels remained constant.
1	Upon	upon	ADP	IN	_	_	_	_	_
2	TPA	TPa	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
3	treatment	treatment	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
4	,	,	PUNCT	,	_	_	_	_	_
5	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
6	activity	activity	NOUN	NN	Number=Sing	_	_	_	_
7	of	of	ADP	IN	_	_	_	_	_
8	ERK1	ERK1	NUM	CD	NumType=Card	_	_	_	_
9	and	and	CCONJ	CC	_	_	_	_	_
10	ERK2	ERK2	NUM	CD	NumType=Card	_	_	_	_
11	rapidly	rapidly	ADV	RB	_	_	_	_	_
12	increased	increase	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	SpaceAfter=No
13	,	,	PUNCT	,	_	_	_	_	_
14	with	with	ADP	IN	_	_	_	_	_
15	maximal	maximal	ADJ	JJ	Degree=Pos	_	_	_	_
16	induction	induction	NOUN	NN	Number=Sing	_	_	_	_
17	between	between	ADP	IN	_	_	_	_	_
18	1	1	NUM	CD	NumType=Card	_	_	_	_
19	and	and	CCONJ	CC	_	_	_	_	_
20	3	3	NUM	CD	NumType=Card	_	_	_	_
21	h	h	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
22	,	,	PUNCT	,	_	_	_	_	_
23	while	while	SCONJ	IN	_	_	_	_	_
24	ERK2	ERK2	NUM	CD	NumType=Card	_	_	_	_
25	protein	protein	NOUN	NN	Number=Sing	_	_	_	_
26	levels	level	NOUN	NNS	Number=Plur	_	_	_	_
27	remained	remain	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
28	constant	constant	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
29	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2498
# text = The activity of JNK1 was also significantly induced, with JNK1 protein levels increasing moderately during exposure to TPA.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	activity	activity	NOUN	NN	Number=Sing	_	_	_	_
3	of	of	ADP	IN	_	_	_	_	_
4	JNK1	JNK1	PROPN	NNP	Number=Sing	_	_	_	_
5	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
6	also	also	ADV	RB	_	_	_	_	_
7	significantly	significantly	ADV	RB	_	_	_	_	_
8	induced	induce	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	SpaceAfter=No
9	,	,	PUNCT	,	_	_	_	_	_
10	with	with	ADP	IN	_	_	_	_	_
11	JNK1	JNK1	PROPN	NNP	Number=Sing	_	_	_	_
12	protein	protein	NOUN	NN	Number=Sing	_	_	_	_
13	levels	level	NOUN	NNS	Number=Plur	_	_	_	_
14	increasing	increase	VERB	VBG	VerbForm=Ger	_	_	_	_
15	moderately	moderately	ADV	RB	_	_	_	_	_
16	during	during	ADP	IN	_	_	_	_	_
17	exposure	exposure	NOUN	NN	Number=Sing	_	_	_	_
18	to	to	ADP	IN	_	_	_	_	_
19	TPA	TPA	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
20	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2499
# text = Treatment of cells with PD98059, a specific inhibitor of mitogen-activated protein kinase kinase (MEK), inhibited TPA-induced ERK2 activity.
1	Treatment	treatment	NOUN	NN	Number=Sing	_	_	_	_
2	of	of	ADP	IN	_	_	_	_	_
3	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
4	with	with	ADP	IN	_	_	_	_	_
5	PD98059	PD98059	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
6	,	,	PUNCT	,	_	_	_	_	_
7	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
8	specific	specific	ADJ	JJ	Degree=Pos	_	_	_	_
9	inhibitor	inhibitor	NOUN	NN	Number=Sing	_	_	_	_
10	of	of	ADP	IN	_	_	_	_	_
11	mitogen	mitogen	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
12	-	-	PUNCT	:	_	_	_	_	SpaceAfter=No
13	activated	activated	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
14	protein	protein	NOUN	NN	Number=Sing	_	_	_	_
15	kinase	kinase	NOUN	NN	Number=Sing	_	_	_	_
16	kinase	kinase	NOUN	NN	Number=Sing	_	_	_	_
17	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
18	MEK	MEK	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
19	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
20	,	,	PUNCT	,	_	_	_	_	_
21	inhibited	inhibit	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
22	TPA	TPa	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
23	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
24	induced	induce	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
25	ERK2	Erk2	NUM	CD	NumType=Card	_	_	_	_
26	activity	activity	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
27	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2500
# text = Furthermore, PD98059 completely blocked the TPA-induced differentiation of ML-1 cells, as assessed by a number of features associated with mononuclear differentiation including changes in morphology, nonspecific esterase activity, phagocytic ability, NADPH oxidase activity, mitochondrial respiration, and c-jun mRNA inducibility.
1	Furthermore	furthermore	ADV	RB	_	_	_	_	SpaceAfter=No
2	,	,	PUNCT	,	_	_	_	_	_
3	PD98059	PD98059	PROPN	NNP	Number=Sing	_	_	_	_
4	completely	completely	ADV	RB	_	_	_	_	_
5	blocked	block	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
6	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
7	TPA	TPa	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
8	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
9	induced	induce	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
10	differentiation	differentiation	NOUN	NN	Number=Sing	_	_	_	_
11	of	of	ADP	IN	_	_	_	_	_
12	ML	ML	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
13	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
14	1	1	NUM	CD	NumType=Card	_	_	_	_
15	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
16	,	,	PUNCT	,	_	_	_	_	_
17	as	as	SCONJ	IN	_	_	_	_	_
18	assessed	assess	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
19	by	by	ADP	IN	_	_	_	_	_
20	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
21	number	number	NOUN	NN	Number=Sing	_	_	_	_
22	of	of	ADP	IN	_	_	_	_	_
23	features	feature	NOUN	NNS	Number=Plur	_	_	_	_
24	associated	associate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
25	with	with	ADP	IN	_	_	_	_	_
26	mononuclear	mononuclear	NOUN	NN	Number=Sing	_	_	_	_
27	differentiation	differentiation	NOUN	NN	Number=Sing	_	_	_	_
28	including	include	VERB	VBG	VerbForm=Ger	_	_	_	_
29	changes	change	NOUN	NNS	Number=Plur	_	_	_	_
30	in	in	ADP	IN	_	_	_	_	_
31	morphology	morphology	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
32	,	,	PUNCT	,	_	_	_	_	_
33	nonspecific	nonspecific	ADJ	JJ	Degree=Pos	_	_	_	_
34	esterase	esterase	NOUN	NN	Number=Sing	_	_	_	_
35	activity	activity	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
36	,	,	PUNCT	,	_	_	_	_	_
37	phagocytic	phagocytic	ADJ	JJ	Degree=Pos	_	_	_	_
38	ability	ability	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
39	,	,	PUNCT	,	_	_	_	_	_
40	NADPH	NADPH	DET	DT	_	_	_	_	_
41	oxidase	oxidase	ADJ	JJ	Degree=Pos	_	_	_	_
42	activity	activity	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
43	,	,	PUNCT	,	_	_	_	_	_
44	mitochondrial	mitochondrial	ADJ	JJ	Degree=Pos	_	_	_	_
45	respiration	respiration	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
46	,	,	PUNCT	,	_	_	_	_	_
47	and	and	CCONJ	CC	_	_	_	_	_
48	c-	c-	SYM	NFP	_	_	_	_	SpaceAfter=No
49	jun	jun	NOUN	NN	Number=Sing	_	_	_	_
50	mRNA	mRNa	NOUN	NN	Number=Sing	_	_	_	_
51	inducibility	inducibility	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
52	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2501
# text = We conclude that activation of the MEK/ERK signaling pathway is necessary for TPA-induced mononuclear cell differentiation.
1	We	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
2	conclude	conclude	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
3	that	that	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
4	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
5	of	of	ADP	IN	_	_	_	_	_
6	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
7	MEK	MEK	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
8	/	/	PUNCT	,	_	_	_	_	SpaceAfter=No
9	ERK	ERK	PROPN	NNP	Number=Sing	_	_	_	_
10	signaling	signaling	NOUN	NN	Number=Sing	_	_	_	_
11	pathway	pathway	NOUN	NN	Number=Sing	_	_	_	_
12	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
13	necessary	necessary	ADJ	JJ	Degree=Pos	_	_	_	_
14	for	for	ADP	IN	_	_	_	_	_
15	TPA	TPA	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
16	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
17	induced	induce	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
18	mononuclear	mononuclear	NOUN	NN	Number=Sing	_	_	_	_
19	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
20	differentiation	differentiation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
21	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 2502
# text = Document 003003247 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	003003247	003003247	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 2503
# text = Estrogen and progesterone induction of survival of monoblastoid cells undergoing TNF-alpha-induced apoptosis.
1	Estrogen	Estrogen	PROPN	NNP	Number=Sing	_	_	_	_
2	and	and	CCONJ	CC	_	_	_	_	_
3	progesterone	progesterone	ADJ	JJ	Degree=Pos	_	_	_	_
4	induction	induction	NOUN	NN	Number=Sing	_	_	_	_
5	of	of	ADP	IN	_	_	_	_	_
6	survival	survival	NOUN	NN	Number=Sing	_	_	_	_
7	of	of	ADP	IN	_	_	_	_	_
8	monoblastoid	monoblastoid	ADJ	JJ	Degree=Pos	_	_	_	_
9	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
10	undergoing	undergo	VERB	VBG	VerbForm=Ger	_	_	_	_
11	TNF	Tnf	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
12	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
13	alpha	alpha	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
14	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
15	induced	induce	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
16	apoptosis	apoptosis	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
17	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 2504
# text = Induction of apoptosis of mononucleated cells is a physiological process for regulating the intensity of the immune response.
1	Induction	Induction	NOUN	NN	Number=Sing	_	_	_	_
2	of	of	ADP	IN	_	_	_	_	_
3	apoptosis	apoptosis	NOUN	NN	Number=Sing	_	_	_	_
4	of	of	ADP	IN	_	_	_	_	_
5	mononucleated	mononucleate	ADJ	JJ	Degree=Pos	_	_	_	_
6	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
7	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
8	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
9	physiological	physiological	ADJ	JJ	Degree=Pos	_	_	_	_
10	process	process	NOUN	NN	Number=Sing	_	_	_	_
11	for	for	SCONJ	IN	_	_	_	_	_
12	regulating	regulate	VERB	VBG	VerbForm=Ger	_	_	_	_
13	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
14	intensity	intensity	NOUN	NN	Number=Sing	_	_	_	_
15	of	of	ADP	IN	_	_	_	_	_
16	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
17	immune	immune	ADJ	JJ	Degree=Pos	_	_	_	_
18	response	response	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
19	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2505
# text = The female steroid hormones estrogen (E2) and progesterone (Prog) are known to modulate the reactivity of the immune system; recently it has been demonstrated that they can regulate induction of apoptosis of endothelial cells and osteoblasts.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	female	female	ADJ	JJ	Degree=Pos	_	_	_	_
3	steroid	steroid	NOUN	NN	Number=Sing	_	_	_	_
4	hormones	hormone	NOUN	NNS	Number=Plur	_	_	_	_
5	estrogen	estrogen	NUM	CD	NumType=Card	_	_	_	_
6	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
7	E2	e2	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
8	)	)	PUNCT	-RRB-	_	_	_	_	_
9	and	and	CCONJ	CC	_	_	_	_	_
10	progesterone	progesterone	NOUN	NN	Number=Sing	_	_	_	_
11	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
12	Prog	Prog	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
13	)	)	PUNCT	-RRB-	_	_	_	_	_
14	are	be	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
15	known	know	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
16	to	to	PART	TO	_	_	_	_	_
17	modulate	modulate	VERB	VB	VerbForm=Inf	_	_	_	_
18	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
19	reactivity	reactivity	NOUN	NN	Number=Sing	_	_	_	_
20	of	of	ADP	IN	_	_	_	_	_
21	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
22	immune	immune	ADJ	JJ	Degree=Pos	_	_	_	_
23	system	system	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
24	;	;	PUNCT	,	_	_	_	_	_
25	recently	recently	ADV	RB	_	_	_	_	_
26	it	it	PRON	PRP	Case=Nom|Gender=Neut|Number=Sing|Person=3|PronType=Prs	_	_	_	_
27	has	have	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
28	been	be	AUX	VBN	Tense=Past|VerbForm=Part	_	_	_	_
29	demonstrated	demonstrate	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
30	that	that	SCONJ	IN	_	_	_	_	_
31	they	they	PRON	PRP	Case=Nom|Number=Plur|Person=3|PronType=Prs	_	_	_	_
32	can	can	AUX	MD	VerbForm=Fin	_	_	_	_
33	regulate	regulate	VERB	VB	VerbForm=Inf	_	_	_	_
34	induction	induction	NOUN	NN	Number=Sing	_	_	_	_
35	of	of	ADP	IN	_	_	_	_	_
36	apoptosis	apoptosis	NOUN	NN	Number=Sing	_	_	_	_
37	of	of	ADP	IN	_	_	_	_	_
38	endothelial	endothelial	ADJ	JJ	Degree=Pos	_	_	_	_
39	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
40	and	and	CCONJ	CC	_	_	_	_	_
41	osteoblasts	osteoblast	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
42	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2506
# text = TNF-alpha-mediated induction of apoptosis has been well characterized in myeloid cells.
1	TNF	Tnf	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
2	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
3	alpha-	alpha-	PUNCT	:	_	_	_	_	SpaceAfter=No
4	mediated	mediate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
5	induction	induction	NOUN	NN	Number=Sing	_	_	_	_
6	of	of	ADP	IN	_	_	_	_	_
7	apoptosis	apoptosis	PRON	DT	Number=Sing|PronType=Dem	_	_	_	_
8	has	have	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
9	been	be	AUX	VBN	Tense=Past|VerbForm=Part	_	_	_	_
10	well	well	ADV	RB	Degree=Pos	_	_	_	_
11	characterized	characterize	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
12	in	in	ADP	IN	_	_	_	_	_
13	myeloid	myeloid	ADJ	JJ	Degree=Pos	_	_	_	_
14	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
15	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2507
# text = We investigated whether E2 and Prog could interfere with TNF-alpha-induced apoptosis of the monoblastoid U937 cell line.
1	We	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
2	investigated	investigate	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
3	whether	whether	SCONJ	IN	_	_	_	_	_
4	E2	E2	NOUN	NN	Number=Sing	_	_	_	_
5	and	and	CCONJ	CC	_	_	_	_	_
6	Prog	Prog	NOUN	NN	Number=Sing	_	_	_	_
7	could	could	AUX	MD	VerbForm=Fin	_	_	_	_
8	interfere	interfere	VERB	VB	VerbForm=Inf	_	_	_	_
9	with	with	ADP	IN	_	_	_	_	_
10	TNF	TNF	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
11	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
12	alpha	alpha	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
13	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
14	induced	induce	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
15	apoptosis	apoptosis	NOUN	NN	Number=Sing	_	_	_	_
16	of	of	ADP	IN	_	_	_	_	_
17	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
18	monoblastoid	monoblastoid	NOUN	NN	Number=Sing	_	_	_	_
19	U937	U937	NUM	CD	NumType=Card	_	_	_	_
20	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
21	line	line	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
22	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2508
# text = Treatment with E2 or Prog increased survival and prevented apoptosis induced by TNF-alpha in both undifferentiated and macrophage-like PMA-differentiated U937 cells, as assessed by trypan blue exclusion cell counting, thymidine incorporation, AnnexinV labeling, followed by flow cytometry and DNA fragmentation studies.
1	Treatment	treatment	NOUN	NN	Number=Sing	_	_	_	_
2	with	with	ADP	IN	_	_	_	_	_
3	E2	E2	NUM	CD	NumType=Card	_	_	_	_
4	or	or	CCONJ	CC	_	_	_	_	_
5	Prog	Prog	PROPN	NNP	Number=Sing	_	_	_	_
6	increased	increase	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
7	survival	survival	NOUN	NN	Number=Sing	_	_	_	_
8	and	and	CCONJ	CC	_	_	_	_	_
9	prevented	prevent	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
10	apoptosis	apoptosis	PRON	PRP$	Gender=Masc|Number=Sing|Person=3|Poss=Yes|PronType=Prs	_	_	_	_
11	induced	induce	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
12	by	by	ADP	IN	_	_	_	_	_
13	TNF	TNF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
14	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
15	alpha	alpha	NOUN	NN	Number=Sing	_	_	_	_
16	in	in	ADP	IN	_	_	_	_	_
17	both	both	CCONJ	CC	_	_	_	_	_
18	undifferentiated	undifferentiated	ADJ	JJ	Degree=Pos	_	_	_	_
19	and	and	CCONJ	CC	_	_	_	_	_
20	macrophage	macrophage	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
21	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
22	like	like	ADP	IN	_	_	_	_	_
23	PMA	PMA	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
24	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
25	differentiated	differentiate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
26	U937	U937	NOUN	NN	Number=Sing	_	_	_	_
27	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
28	,	,	PUNCT	,	_	_	_	_	_
29	as	as	SCONJ	IN	_	_	_	_	_
30	assessed	assess	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
31	by	by	ADP	IN	_	_	_	_	_
32	trypan	trypan	ADJ	JJ	Degree=Pos	_	_	_	_
33	blue	blue	ADJ	JJ	Degree=Pos	_	_	_	_
34	exclusion	exclusion	NOUN	NN	Number=Sing	_	_	_	_
35	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
36	counting	counting	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
37	,	,	PUNCT	,	_	_	_	_	_
38	thymidine	thymidine	NOUN	NN	Number=Sing	_	_	_	_
39	incorporation	incorporation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
40	,	,	PUNCT	,	_	_	_	_	_
41	AnnexinV	AnnexinV	PROPN	NNP	Number=Sing	_	_	_	_
42	labeling	labeling	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
43	,	,	PUNCT	,	_	_	_	_	_
44	followed	follow	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
45	by	by	ADP	IN	_	_	_	_	_
46	flow	flow	NOUN	NN	Number=Sing	_	_	_	_
47	cytometry	cytometry	NOUN	NN	Number=Sing	_	_	_	_
48	and	and	CCONJ	CC	_	_	_	_	_
49	DNA	dna	NOUN	NN	Number=Sing	_	_	_	_
50	fragmentation	fragmentation	NOUN	NN	Number=Sing	_	_	_	_
51	studies	study	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
52	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2509
# text = This effect can be associated with the activation of specific hormone receptors, since we observed the expression of the estrogen receptor alpha (ER-alpha), ER-beta, and progesterone receptor (PR) mRNAs; the ER-alpha protein expression was confirmed by immunocytochemical analysis.
1	This	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
2	effect	effect	NOUN	NN	Number=Sing	_	_	_	_
3	can	can	AUX	MD	VerbForm=Fin	_	_	_	_
4	be	be	AUX	VB	VerbForm=Inf	_	_	_	_
5	associated	associate	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
6	with	with	ADP	IN	_	_	_	_	_
7	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
8	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
9	of	of	ADP	IN	_	_	_	_	_
10	specific	specific	ADJ	JJ	Degree=Pos	_	_	_	_
11	hormone	hormone	NOUN	NN	Number=Sing	_	_	_	_
12	receptors	receptor	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
13	,	,	PUNCT	,	_	_	_	_	_
14	since	since	SCONJ	IN	_	_	_	_	_
15	we	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
16	observed	observe	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
17	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
18	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
19	of	of	ADP	IN	_	_	_	_	_
20	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
21	estrogen	estrogen	ADJ	JJ	Degree=Pos	_	_	_	_
22	receptor	receptor	NOUN	NN	Number=Sing	_	_	_	_
23	alpha	alpha	NOUN	NN	Number=Sing	_	_	_	_
24	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
25	ER	er	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
26	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
27	alpha	alpha	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
28	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
29	,	,	PUNCT	,	_	_	_	_	_
30	ER	er	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
31	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
32	beta	beta	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
33	,	,	PUNCT	,	_	_	_	_	_
34	and	and	CCONJ	CC	_	_	_	_	_
35	progesterone	progesterone	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
36	receptor	receptor	NOUN	NN	Number=Sing	_	_	_	_
37	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
38	PR	pr	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
39	)	)	PUNCT	-RRB-	_	_	_	_	_
40	mRNAs	mRNAs	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
41	;	;	PUNCT	,	_	_	_	_	_
42	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
43	ER-	ER-	X	AFX	_	_	_	_	SpaceAfter=No
44	alpha	alpha	X	FW	Foreign=Yes	_	_	_	_
45	protein	protein	NOUN	NN	Number=Sing	_	_	_	_
46	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
47	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
48	confirmed	confirm	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
49	by	by	ADP	IN	_	_	_	_	_
50	immunocytochemical	immunocytochemical	ADJ	JJ	Degree=Pos	_	_	_	_
51	analysis	analysis	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
52	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2510
# text = In addition, hormone-mediated survival against apoptosis was concentration dependent, reaching the half-maximal effect at 10 nM and blocked by the ER antagonist ICI 182,780 in undifferentiated cells, further supporting a receptor-mediated mechanism of cell survival.
1	In	in	ADP	IN	_	_	_	_	_
2	addition	addition	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
3	,	,	PUNCT	,	_	_	_	_	_
4	hormone	hormone	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
5	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
6	mediated	mediate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
7	survival	survival	NOUN	NN	Number=Sing	_	_	_	_
8	against	against	ADP	IN	_	_	_	_	_
9	apoptosis	apoptosis	NOUN	NN	Number=Sing	_	_	_	_
10	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
11	concentration	concentration	NOUN	NN	Number=Sing	_	_	_	_
12	dependent	dependent	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
13	,	,	PUNCT	,	_	_	_	_	_
14	reaching	reach	VERB	VBG	VerbForm=Ger	_	_	_	_
15	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
16	half	half	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
17	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
18	maximal	maximal	ADJ	JJ	Degree=Pos	_	_	_	_
19	effect	effect	NOUN	NN	Number=Sing	_	_	_	_
20	at	at	ADP	IN	_	_	_	_	_
21	10	10	NUM	CD	NumType=Card	_	_	_	_
22	nM	nm	NOUN	NN	Number=Sing	_	_	_	_
23	and	and	CCONJ	CC	_	_	_	_	_
24	blocked	block	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
25	by	by	ADP	IN	_	_	_	_	_
26	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
27	ER	er	NOUN	NN	Number=Sing	_	_	_	_
28	antagonist	antagonist	NOUN	NN	Number=Sing	_	_	_	_
29	ICI	ICI	PROPN	NNP	Number=Sing	_	_	_	_
30	182,780	182,780	NUM	CD	NumType=Card	_	_	_	_
31	in	in	ADP	IN	_	_	_	_	_
32	undifferentiated	undifferentiated	ADJ	JJ	Degree=Pos	_	_	_	_
33	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
34	,	,	PUNCT	,	_	_	_	_	_
35	further	further	ADV	RB	_	_	_	_	_
36	supporting	support	VERB	VBG	VerbForm=Ger	_	_	_	_
37	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
38	receptor	receptor	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
39	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
40	mediated	mediate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
41	mechanism	mechanism	NOUN	NN	Number=Sing	_	_	_	_
42	of	of	ADP	IN	_	_	_	_	_
43	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
44	survival	survival	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
45	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2511
# text = Other steroid receptor drugs such as Raloxifene, RU486, or the ICI 182,780 in PMA-differentiated cells displayed agonist activity by preventing TNF-alpha-induced apoptosis as efficiently as the hormones alone, providing further evidence to the notion that steroid receptor drugs may manifest agonist or antagonist activities depending on the cellular context in which they are studied.
1	Other	other	ADJ	JJ	Degree=Pos	_	_	_	_
2	steroid	steroid	ADJ	JJ	Degree=Pos	_	_	_	_
3	receptor	receptor	NOUN	NN	Number=Sing	_	_	_	_
4	drugs	drug	NOUN	NNS	Number=Plur	_	_	_	_
5	such	such	ADJ	JJ	Degree=Pos	_	_	_	_
6	as	as	ADP	IN	_	_	_	_	_
7	Raloxifene	Raloxifene	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
8	,	,	PUNCT	,	_	_	_	_	_
9	RU486	RU486	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
10	,	,	PUNCT	,	_	_	_	_	_
11	or	or	CCONJ	CC	_	_	_	_	_
12	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
13	ICI	ICI	PROPN	NNP	Number=Sing	_	_	_	_
14	182,780	182,780	NUM	CD	NumType=Card	_	_	_	_
15	in	in	ADP	IN	_	_	_	_	_
16	PMA	PMA	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
17	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
18	differentiated	differentiate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
19	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
20	displayed	display	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
21	agonist	agonist	ADJ	JJ	Degree=Pos	_	_	_	_
22	activity	activity	NOUN	NN	Number=Sing	_	_	_	_
23	by	by	SCONJ	IN	_	_	_	_	_
24	preventing	prevent	VERB	VBG	VerbForm=Ger	_	_	_	_
25	TNF	TNF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
26	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
27	alpha	alpha	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
28	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
29	induced	induce	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
30	apoptosis	apoptosis	NOUN	NN	Number=Sing	_	_	_	_
31	as	as	SCONJ	IN	_	_	_	_	_
32	efficiently	efficiently	ADV	RB	_	_	_	_	_
33	as	as	ADP	IN	_	_	_	_	_
34	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
35	hormones	hormone	NOUN	NNS	Number=Plur	_	_	_	_
36	alone	alone	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
37	,	,	PUNCT	,	_	_	_	_	_
38	providing	provide	VERB	VBG	VerbForm=Ger	_	_	_	_
39	further	further	ADJ	JJ	Degree=Pos	_	_	_	_
40	evidence	evidence	NOUN	NN	Number=Sing	_	_	_	_
41	to	to	ADP	IN	_	_	_	_	_
42	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
43	notion	notion	NOUN	NN	Number=Sing	_	_	_	_
44	that	that	PRON	WDT	PronType=Rel	_	_	_	_
45	steroid	steroid	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
46	receptor	receptor	NOUN	NN	Number=Sing	_	_	_	_
47	drugs	drug	NOUN	NNS	Number=Plur	_	_	_	_
48	may	may	AUX	MD	VerbForm=Fin	_	_	_	_
49	manifest	manifest	VERB	VB	VerbForm=Inf	_	_	_	_
50	agonist	agonist	ADJ	JJ	Degree=Pos	_	_	_	_
51	or	or	CCONJ	CC	_	_	_	_	_
52	antagonist	antagonist	ADJ	JJ	Degree=Pos	_	_	_	_
53	activities	activity	NOUN	NNS	Number=Plur	_	_	_	_
54	depending	depend	VERB	VBG	VerbForm=Ger	_	_	_	_
55	on	on	ADP	IN	_	_	_	_	_
56	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
57	cellular	cellular	ADJ	JJ	Degree=Pos	_	_	_	_
58	context	context	NOUN	NN	Number=Sing	_	_	_	_
59	in	in	ADP	IN	_	_	_	_	_
60	which	which	PRON	WDT	PronType=Rel	_	_	_	_
61	they	they	PRON	PRP	Case=Nom|Number=Plur|Person=3|PronType=Prs	_	_	_	_
62	are	be	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
63	studied	study	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	SpaceAfter=No
64	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2512
# text = Treatment with E2 was also associated with a time-dependent decrease in the mRNA level of the proapoptotic Nip-2 protein, supporting the hypothesis that hormone responsiveness of U937 cells is mediated by target gene transcription.
1	Treatment	treatment	NOUN	NN	Number=Sing	_	_	_	_
2	with	with	ADP	IN	_	_	_	_	_
3	E2	e2	NOUN	NN	Number=Sing	_	_	_	_
4	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
5	also	also	ADV	RB	_	_	_	_	_
6	associated	associate	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
7	with	with	ADP	IN	_	_	_	_	_
8	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
9	time	time	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
10	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
11	dependent	dependent	ADJ	JJ	Degree=Pos	_	_	_	_
12	decrease	decrease	NOUN	NN	Number=Sing	_	_	_	_
13	in	in	ADP	IN	_	_	_	_	_
14	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
15	mRNA	mRNA	PROPN	NNP	Number=Sing	_	_	_	_
16	level	level	NOUN	NN	Number=Sing	_	_	_	_
17	of	of	ADP	IN	_	_	_	_	_
18	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
19	proapoptotic	proapoptotic	ADJ	JJ	Degree=Pos	_	_	_	_
20	Nip	Nip	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
21	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
22	2	2	NUM	CD	NumType=Card	_	_	_	_
23	protein	protein	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
24	,	,	PUNCT	,	_	_	_	_	_
25	supporting	support	VERB	VBG	VerbForm=Ger	_	_	_	_
26	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
27	hypothesis	hypothesis	NOUN	NN	Number=Sing	_	_	_	_
28	that	that	PRON	WDT	PronType=Rel	_	_	_	_
29	hormone	hormone	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
30	responsiveness	responsiveness	NOUN	NN	Number=Sing	_	_	_	_
31	of	of	ADP	IN	_	_	_	_	_
32	U937	U937	NUM	CD	NumType=Card	_	_	_	_
33	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
34	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
35	mediated	mediate	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
36	by	by	ADP	IN	_	_	_	_	_
37	target	target	NOUN	NN	Number=Sing	_	_	_	_
38	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
39	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
40	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2513
# text = Together, these results demonstrate that ER and PR can be activated by endogenous or exogenous ligands to induce a genetic response that impairs TNF-alpha-induced apoptosis in U937 cells.
1	Together	together	ADV	RB	_	_	_	_	SpaceAfter=No
2	,	,	PUNCT	,	_	_	_	_	_
3	these	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
4	results	result	NOUN	NNS	Number=Plur	_	_	_	_
5	demonstrate	demonstrate	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
6	that	that	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
7	ER	er	NOUN	NN	Number=Sing	_	_	_	_
8	and	and	CCONJ	CC	_	_	_	_	_
9	PR	pr	NOUN	NN	Number=Sing	_	_	_	_
10	can	can	AUX	MD	VerbForm=Fin	_	_	_	_
11	be	be	AUX	VB	VerbForm=Inf	_	_	_	_
12	activated	activate	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
13	by	by	ADP	IN	_	_	_	_	_
14	endogenous	endogenous	ADJ	JJ	Degree=Pos	_	_	_	_
15	or	or	CCONJ	CC	_	_	_	_	_
16	exogenous	exogenous	ADJ	JJ	Degree=Pos	_	_	_	_
17	ligands	ligand	NOUN	NNS	Number=Plur	_	_	_	_
18	to	to	PART	TO	_	_	_	_	_
19	induce	induce	VERB	VB	VerbForm=Inf	_	_	_	_
20	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
21	genetic	genetic	ADJ	JJ	Degree=Pos	_	_	_	_
22	response	response	NOUN	NN	Number=Sing	_	_	_	_
23	that	that	PRON	WDT	PronType=Rel	_	_	_	_
24	impairs	impair	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
25	TNF	Tnf	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
26	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
27	alpha	alpha	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
28	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
29	induced	induce	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
30	apoptosis	apoptosis	NOUN	NN	Number=Sing	_	_	_	_
31	in	in	ADP	IN	_	_	_	_	_
32	U937	U937	NUM	CD	NumType=Card	_	_	_	_
33	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
34	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2514
# text = The data presented here suggest that the female steroid receptors play a role in regulation of the immune response by preventing apoptosis of monoblastoid cells; this effect might have important consequences in the clinical use of steroid receptor drugs.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	data	data	NOUN	NN	Number=Sing	_	_	_	_
3	presented	present	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
4	here	here	ADV	RB	PronType=Dem	_	_	_	_
5	suggest	suggest	ADV	RBS	Degree=Sup	_	_	_	_
6	that	that	SCONJ	IN	_	_	_	_	_
7	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
8	female	female	ADJ	JJ	Degree=Pos	_	_	_	_
9	steroid	steroid	NOUN	NN	Number=Sing	_	_	_	_
10	receptors	receptor	NOUN	NNS	Number=Plur	_	_	_	_
11	play	play	VERB	VB	VerbForm=Inf	_	_	_	_
12	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
13	role	role	NOUN	NN	Number=Sing	_	_	_	_
14	in	in	ADP	IN	_	_	_	_	_
15	regulation	regulation	NOUN	NN	Number=Sing	_	_	_	_
16	of	of	ADP	IN	_	_	_	_	_
17	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
18	immune	immune	ADJ	JJ	Degree=Pos	_	_	_	_
19	response	response	NOUN	NN	Number=Sing	_	_	_	_
20	by	by	SCONJ	IN	_	_	_	_	_
21	preventing	prevent	VERB	VBG	VerbForm=Ger	_	_	_	_
22	apoptosis	apoptosis	NOUN	NN	Number=Sing	_	_	_	_
23	of	of	ADP	IN	_	_	_	_	_
24	monoblastoid	monoblastoid	ADJ	JJ	Degree=Pos	_	_	_	_
25	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
26	;	;	PUNCT	,	_	_	_	_	_
27	this	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
28	effect	effect	NOUN	NN	Number=Sing	_	_	_	_
29	might	might	AUX	MD	VerbForm=Fin	_	_	_	_
30	have	have	VERB	VB	VerbForm=Inf	_	_	_	_
31	important	important	ADJ	JJ	Degree=Pos	_	_	_	_
32	consequences	consequence	NOUN	NNS	Number=Plur	_	_	_	_
33	in	in	ADP	IN	_	_	_	_	_
34	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
35	clinical	clinical	ADJ	JJ	Degree=Pos	_	_	_	_
36	use	use	NOUN	NN	Number=Sing	_	_	_	_
37	of	of	ADP	IN	_	_	_	_	_
38	steroid	steroid	ADJ	JJ	Degree=Pos	_	_	_	_
39	receptor	receptor	NOUN	NN	Number=Sing	_	_	_	_
40	drugs	drug	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
41	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2515
# text = --Vegeto, E., Pollio, G., Pellicciari, C., Maggi, A.
1	--	--	PUNCT	NFP	_	_	_	_	SpaceAfter=No
2	Vegeto	Vegeto	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
3	,	,	PUNCT	,	_	_	_	_	_
4	E.	E.	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
5	,	,	PUNCT	,	_	_	_	_	_
6	Pollio	Pollio	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
7	,	,	PUNCT	,	_	_	_	_	_
8	G.	G.	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
9	,	,	PUNCT	,	_	_	_	_	_
10	Pellicciari	Pellicciari	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
11	,	,	PUNCT	,	_	_	_	_	_
12	C.	c.	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
13	,	,	PUNCT	,	_	_	_	_	_
14	Maggi	Maggi	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
15	,	,	PUNCT	,	_	_	_	_	_
16	A	A	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
17	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2516
# text = Estrogen and progesterone induction of survival of monoblastoid cells undergoing TNF-alpha-inuced apoptosis.
1	Estrogen	Estrogen	PROPN	NNP	Number=Sing	_	_	_	_
2	and	and	CCONJ	CC	_	_	_	_	_
3	progesterone	progesterone	ADJ	JJ	Degree=Pos	_	_	_	_
4	induction	induction	NOUN	NN	Number=Sing	_	_	_	_
5	of	of	ADP	IN	_	_	_	_	_
6	survival	survival	NOUN	NN	Number=Sing	_	_	_	_
7	of	of	ADP	IN	_	_	_	_	_
8	monoblastoid	monoblastoid	ADJ	JJ	Degree=Pos	_	_	_	_
9	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
10	undergoing	undergo	VERB	VBG	VerbForm=Ger	_	_	_	_
11	TNF	Tnf	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
12	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
13	alpha	alpha	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
14	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
15	inuced	inuce	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
16	apoptosis.	apoptosis.	NOUN	NN	Number=Sing	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 2517
# text = Document 003003251 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	003003251	003003251	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 2518
# text = Diminished responses to IL-13 by human monocytes differentiated in vitro: role of the IL-13Ralpha1 chain and STAT6.
1	Diminished	Diminish	ADJ	JJ	Degree=Pos	_	_	_	_
2	responses	response	NOUN	NNS	Number=Plur	_	_	_	_
3	to	to	ADP	IN	_	_	_	_	_
4	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
5	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
6	13	13	NUM	CD	NumType=Card	_	_	_	_
7	by	by	ADP	IN	_	_	_	_	_
8	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
9	monocytes	monocyte	NOUN	NNS	Number=Plur	_	_	_	_
10	differentiated	differentiate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
11	in	in	ADP	IN	_	_	_	_	_
12	vitro	vitro	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
13	:	:	PUNCT	:	_	_	_	_	_
14	role	role	NOUN	NN	Number=Sing	_	_	_	_
15	of	of	ADP	IN	_	_	_	_	_
16	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
17	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
18	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
19	13	13	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
20	Ralpha1	ralpha1	NUM	CD	NumType=Card	_	_	_	_
21	chain	chain	NOUN	NN	Number=Sing	_	_	_	_
22	and	and	CCONJ	CC	_	_	_	_	_
23	STAT6	Stat6	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
24	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 2519
# text = The primary IL-13 receptor complex on human monocytes is believed to be a heterodimer comprised of the IL-4R alpha chain and the IL-2R gamma chain (gamma(c))-like molecule, IL-13R alpha1.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	primary	primary	ADJ	JJ	Degree=Pos	_	_	_	_
3	IL	Il	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
4	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
5	13	13	NUM	CD	NumType=Card	_	_	_	_
6	receptor	receptor	NOUN	NN	Number=Sing	_	_	_	_
7	complex	complex	NOUN	NN	Number=Sing	_	_	_	_
8	on	on	ADP	IN	_	_	_	_	_
9	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
10	monocytes	monocyte	NOUN	NNS	Number=Plur	_	_	_	_
11	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
12	believed	believe	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
13	to	to	PART	TO	_	_	_	_	_
14	be	be	AUX	VB	VerbForm=Inf	_	_	_	_
15	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
16	heterodimer	heterodimer	NOUN	NN	Number=Sing	_	_	_	_
17	comprised	comprise	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
18	of	of	ADP	IN	_	_	_	_	_
19	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
20	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
21	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
22	4R	4R	PROPN	NNP	Number=Sing	_	_	_	_
23	alpha	alpha	NOUN	NN	Number=Sing	_	_	_	_
24	chain	chain	NOUN	NN	Number=Sing	_	_	_	_
25	and	and	CCONJ	CC	_	_	_	_	_
26	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
27	IL	Il	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
28	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
29	2R	2r	NOUN	NN	Number=Sing	_	_	_	_
30	gamma	gamma	NOUN	NN	Number=Sing	_	_	_	_
31	chain	chain	NOUN	NN	Number=Sing	_	_	_	_
32	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
33	gamma	gamma	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
34	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
35	c	c	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
36	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
37	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
38	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
39	like	like	ADJ	JJ	Degree=Pos	_	_	_	_
40	molecule	molecule	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
41	,	,	PUNCT	,	_	_	_	_	_
42	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
43	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
44	13R	13R	PROPN	NNP	Number=Sing	_	_	_	_
45	alpha1	alpha1	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
46	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2520
# text = mRNA levels for IL-13R alpha1, but not IL-4R alpha, were markedly decreased in in vitro monocyte-derived macrophages (MDMac), and with increasing time of monocytes in culture correlated with the loss of IL-13 regulation of lipopolysaccharide-induced TNF-alpha production.
1	mRNA	mRNa	NOUN	NN	Number=Sing	_	_	_	_
2	levels	level	NOUN	NNS	Number=Plur	_	_	_	_
3	for	for	ADP	IN	_	_	_	_	_
4	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
5	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
6	13R	13R	PROPN	NNP	Number=Sing	_	_	_	_
7	alpha1	alpha1	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
8	,	,	PUNCT	,	_	_	_	_	_
9	but	but	CCONJ	CC	_	_	_	_	_
10	not	not	ADV	RB	_	_	_	_	_
11	IL	Il	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
12	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
13	4R	4r	NOUN	NN	Number=Sing	_	_	_	_
14	alpha	alpha	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
15	,	,	PUNCT	,	_	_	_	_	_
16	were	be	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
17	markedly	markedly	ADV	RB	_	_	_	_	_
18	decreased	decrease	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
19	in	in	ADP	IN	_	_	_	_	_
20	in	in	ADP	IN	_	_	_	_	_
21	vitro	vitro	NUM	CD	NumType=Card	_	_	_	_
22	monocyte	monocyte	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
23	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
24	derived	derive	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
25	macrophages	macrophage	NOUN	NNS	Number=Plur	_	_	_	_
26	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
27	MDMac	MDMac	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
28	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
29	,	,	PUNCT	,	_	_	_	_	_
30	and	and	CCONJ	CC	_	_	_	_	_
31	with	with	SCONJ	IN	_	_	_	_	_
32	increasing	increase	VERB	VBG	VerbForm=Ger	_	_	_	_
33	time	time	NOUN	NN	Number=Sing	_	_	_	_
34	of	of	ADP	IN	_	_	_	_	_
35	monocytes	monocyte	NOUN	NNS	Number=Plur	_	_	_	_
36	in	in	ADP	IN	_	_	_	_	_
37	culture	culture	NOUN	NN	Number=Sing	_	_	_	_
38	correlated	correlate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
39	with	with	ADP	IN	_	_	_	_	_
40	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
41	loss	loss	NOUN	NN	Number=Sing	_	_	_	_
42	of	of	ADP	IN	_	_	_	_	_
43	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
44	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
45	13	13	NUM	CD	NumType=Card	_	_	_	_
46	regulation	regulation	NOUN	NN	Number=Sing	_	_	_	_
47	of	of	ADP	IN	_	_	_	_	_
48	lipopolysaccharide	lipopolysaccharide	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
49	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
50	induced	induce	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
51	TNF	Tnf	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
52	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
53	alpha	alpha	NOUN	NN	Number=Sing	_	_	_	_
54	production	production	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
55	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2521
# text = Analysis of cell lines Daudi and THP-1 that differentially express gamma(c) and IL-13R alpha1 showed that IL-13 can activate STAT6 in IL-13R alpha1-positive THP-1 cells but not in gamma(c)-positive, IL-13R alpha1-negative Daudi cells.
1	Analysis	analysis	NOUN	NN	Number=Sing	_	_	_	_
2	of	of	ADP	IN	_	_	_	_	_
3	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
4	lines	line	NOUN	NNS	Number=Plur	_	_	_	_
5	Daudi	Daudi	PROPN	NNP	Number=Sing	_	_	_	_
6	and	and	CCONJ	CC	_	_	_	_	_
7	THP	THP	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
8	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
9	1	1	NUM	CD	NumType=Card	_	_	_	_
10	that	that	ADV	WRB	PronType=Dem	_	_	_	_
11	differentially	differentially	ADV	RB	_	_	_	_	_
12	express	express	ADJ	JJ	Degree=Pos	_	_	_	_
13	gamma	gamma	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
14	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
15	c	c	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
16	)	)	PUNCT	-RRB-	_	_	_	_	_
17	and	and	CCONJ	CC	_	_	_	_	_
18	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
19	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
20	13R	13R	PROPN	NNP	Number=Sing	_	_	_	_
21	alpha1	alpha1	NOUN	NN	Number=Sing	_	_	_	_
22	showed	show	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
23	that	that	SCONJ	IN	_	_	_	_	_
24	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
25	-	-	SYM	SYM	_	_	_	_	SpaceAfter=No
26	13	13	NUM	CD	NumType=Card	_	_	_	_
27	can	can	AUX	MD	VerbForm=Fin	_	_	_	_
28	activate	activate	VERB	VB	VerbForm=Inf	_	_	_	_
29	STAT6	STAT6	PROPN	NNP	Number=Sing	_	_	_	_
30	in	in	ADP	IN	_	_	_	_	_
31	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
32	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
33	13R	13R	PROPN	NNP	Number=Sing	_	_	_	_
34	alpha1	alpha1	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
35	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
36	positive	positive	ADJ	JJ	Degree=Pos	_	_	_	_
37	THP	Thp	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
38	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
39	1	1	NUM	CD	NumType=Card	_	_	_	_
40	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
41	but	but	CCONJ	CC	_	_	_	_	_
42	not	not	PART	RB	_	_	_	_	_
43	in	in	ADP	IN	_	_	_	_	_
44	gamma	gamma	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
45	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
46	c	c	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
47	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
48	-	-	PUNCT	:	_	_	_	_	SpaceAfter=No
49	positive	positive	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
50	,	,	PUNCT	,	_	_	_	_	_
51	IL	Il	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
52	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
53	13R	13r	PROPN	NNP	Number=Sing	_	_	_	_
54	alpha1	alpha1	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
55	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
56	negative	negative	ADJ	JJ	Degree=Pos	_	_	_	_
57	Daudi	Daudi	NOUN	NN	Number=Sing	_	_	_	_
58	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
59	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2522
# text = IL-13 activation of STAT6 was reduced in MDMac which was associated with diminished IL-13-induced expression of CD23 and MHC class II.
1	IL	Il	INTJ	UH	_	_	_	_	SpaceAfter=No
2	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
3	13	13	NUM	CD	NumType=Card	_	_	_	_
4	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
5	of	of	ADP	IN	_	_	_	_	_
6	STAT6	Stat6	PROPN	NNP	Number=Sing	_	_	_	_
7	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
8	reduced	reduce	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
9	in	in	ADP	IN	_	_	_	_	_
10	MDMac	MDMac	PROPN	NNP	Number=Sing	_	_	_	_
11	which	which	PRON	WDT	PronType=Rel	_	_	_	_
12	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
13	associated	associate	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
14	with	with	ADP	IN	_	_	_	_	_
15	diminished	diminish	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
16	IL-	Il-	SYM	SYM	_	_	_	_	SpaceAfter=No
17	13	13	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
18	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
19	induced	induce	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
20	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
21	of	of	ADP	IN	_	_	_	_	_
22	CD23	CD23	NOUN	NN	Number=Sing	_	_	_	_
23	and	and	CCONJ	CC	_	_	_	_	_
24	MHC	MHC	PROPN	NNP	Number=Sing	_	_	_	_
25	class	class	NOUN	NN	Number=Sing	_	_	_	_
26	II	ii	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
27	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2523
# text = However, with reduced IL-13R alpha1 expression and low nuclear STAT6 activity, some IL-13-induced responses were unaltered in magnitude in MDMac.
1	However	however	ADV	RB	_	_	_	_	SpaceAfter=No
2	,	,	PUNCT	,	_	_	_	_	_
3	with	with	ADP	IN	_	_	_	_	_
4	reduced	reduce	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
5	IL	Il	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
6	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
7	13R	13r	NOUN	NN	Number=Sing	_	_	_	_
8	alpha1	alpha1	NOUN	NN	Number=Sing	_	_	_	_
9	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
10	and	and	CCONJ	CC	_	_	_	_	_
11	low	low	ADJ	JJ	Degree=Pos	_	_	_	_
12	nuclear	nuclear	ADJ	JJ	Degree=Pos	_	_	_	_
13	STAT6	Stat6	NOUN	NN	Number=Sing	_	_	_	_
14	activity	activity	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
15	,	,	PUNCT	,	_	_	_	_	_
16	some	some	DET	DT	_	_	_	_	_
17	IL	Il	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
18	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
19	13	13	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
20	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
21	induced	induce	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
22	responses	response	NOUN	NNS	Number=Plur	_	_	_	_
23	were	be	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
24	unaltered	unalter	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
25	in	in	ADP	IN	_	_	_	_	_
26	magnitude	magnitude	NOUN	NN	Number=Sing	_	_	_	_
27	in	in	ADP	IN	_	_	_	_	_
28	MDMac	MDMac	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
29	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2524
# text = In the absence of functional IL-13R alpha1 and gamma(c), IL-13 must signal through an alternative receptor complex on MDMac.
1	In	in	ADP	IN	_	_	_	_	_
2	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
3	absence	absence	NOUN	NN	Number=Sing	_	_	_	_
4	of	of	ADP	IN	_	_	_	_	_
5	functional	functional	ADJ	JJ	Degree=Pos	_	_	_	_
6	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
7	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
8	13R	13R	PROPN	NNP	Number=Sing	_	_	_	_
9	alpha1	alpha1	NOUN	NN	Number=Sing	_	_	_	_
10	and	and	CCONJ	CC	_	_	_	_	_
11	gamma	gamma	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
12	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
13	c	c	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
14	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
15	,	,	PUNCT	,	_	_	_	_	_
16	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
17	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
18	13	13	NUM	CD	NumType=Card	_	_	_	_
19	must	must	AUX	MD	VerbForm=Fin	_	_	_	_
20	signal	signal	VERB	VB	VerbForm=Inf	_	_	_	_
21	through	through	ADP	IN	_	_	_	_	_
22	an	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
23	alternative	alternative	ADJ	JJ	Degree=Pos	_	_	_	_
24	receptor	receptor	NOUN	NN	Number=Sing	_	_	_	_
25	complex	complex	NOUN	NN	Number=Sing	_	_	_	_
26	on	on	ADP	IN	_	_	_	_	_
27	MDMac	MDMac	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
28	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2525
# text = Experiments with a blocking antibody to IL-4R alpha showed that this chain remains an essential component of the IL-13 receptor complex on MDMac.
1	Experiments	Experiment	NOUN	NNS	Number=Plur	_	_	_	_
2	with	with	ADP	IN	_	_	_	_	_
3	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
4	blocking	block	NOUN	NN	Number=Sing	_	_	_	_
5	antibody	antibody	NOUN	NN	Number=Sing	_	_	_	_
6	to	to	ADP	IN	_	_	_	_	_
7	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
8	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
9	4	for	X	GW	_	_	_	_	SpaceAfter=No
10	R	r	X	GW	_	_	_	_	_
11	alpha	alpha	X	GW	_	_	_	_	_
12	showed	show	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
13	that	that	SCONJ	IN	_	_	_	_	_
14	this	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
15	chain	chain	NOUN	NN	Number=Sing	_	_	_	_
16	remains	remain	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
17	an	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
18	essential	essential	ADJ	JJ	Degree=Pos	_	_	_	_
19	component	component	NOUN	NN	Number=Sing	_	_	_	_
20	of	of	ADP	IN	_	_	_	_	_
21	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
22	IL	Il	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
23	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
24	13	13	NUM	CD	NumType=Card	_	_	_	_
25	receptor	receptor	NOUN	NN	Number=Sing	_	_	_	_
26	complex	complex	NOUN	NN	Number=Sing	_	_	_	_
27	on	on	ADP	IN	_	_	_	_	_
28	MDMac	MDMac	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
29	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 2526
# text = Document 003003255 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	003003255	003003255	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 2527
# text = A role for RanBP1 in the release of CRM1 from the nuclear pore complex in a terminal step of nuclear export.
1	A	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
2	role	role	NOUN	NN	Number=Sing	_	_	_	_
3	for	for	ADP	IN	_	_	_	_	_
4	RanBP1	RanBP1	NUM	CD	NumType=Card	_	_	_	_
5	in	in	ADP	IN	_	_	_	_	_
6	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
7	release	release	NOUN	NN	Number=Sing	_	_	_	_
8	of	of	ADP	IN	_	_	_	_	_
9	CRM1	CRM1	PROPN	NNP	Number=Sing	_	_	_	_
10	from	from	ADP	IN	_	_	_	_	_
11	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
12	nuclear	nuclear	ADJ	JJ	Degree=Pos	_	_	_	_
13	pore	pore	NOUN	NN	Number=Sing	_	_	_	_
14	complex	complex	NOUN	NN	Number=Sing	_	_	_	_
15	in	in	ADP	IN	_	_	_	_	_
16	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
17	terminal	terminal	ADJ	JJ	Degree=Pos	_	_	_	_
18	step	step	NOUN	NN	Number=Sing	_	_	_	_
19	of	of	ADP	IN	_	_	_	_	_
20	nuclear	nuclear	ADJ	JJ	Degree=Pos	_	_	_	_
21	export	export	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
22	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 2528
# text = We recently developed an assay in which nuclear export of the shuttling transcription factor NFAT (nuclear factor of activated T cells) can be reconstituted in permeabilized cells with the GTPase Ran and the nuclear export receptor CRM1.
1	We	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
2	recently	recently	ADV	RB	_	_	_	_	_
3	developed	develop	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
4	an	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
5	assay	assay	NOUN	NN	Number=Sing	_	_	_	_
6	in	in	ADP	IN	_	_	_	_	_
7	which	which	PRON	WDT	PronType=Rel	_	_	_	_
8	nuclear	nuclear	ADJ	JJ	Degree=Pos	_	_	_	_
9	export	export	NOUN	NN	Number=Sing	_	_	_	_
10	of	of	ADP	IN	_	_	_	_	_
11	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
12	shuttling	shuttling	VERB	VBG	VerbForm=Ger	_	_	_	_
13	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
14	factor	factor	NOUN	NN	Number=Sing	_	_	_	_
15	NFAT	NFAT	PROPN	NNP	Number=Sing	_	_	_	_
16	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
17	nuclear	nuclear	ADJ	JJ	Degree=Pos	_	_	_	_
18	factor	factor	NOUN	NN	Number=Sing	_	_	_	_
19	of	of	ADP	IN	_	_	_	_	_
20	activated	activate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
21	T	t	PROPN	NNP	Number=Sing	_	_	_	_
22	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
23	)	)	PUNCT	-RRB-	_	_	_	_	_
24	can	can	AUX	MD	VerbForm=Fin	_	_	_	_
25	be	be	AUX	VB	VerbForm=Inf	_	_	_	_
26	reconstituted	reconstitute	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
27	in	in	ADP	IN	_	_	_	_	_
28	permeabilized	permeabilize	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
29	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
30	with	with	ADP	IN	_	_	_	_	_
31	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
32	GTPase	GTPase	PROPN	NNP	Number=Sing	_	_	_	_
33	Ran	ran	PROPN	NNP	Number=Sing	_	_	_	_
34	and	and	CCONJ	CC	_	_	_	_	_
35	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
36	nuclear	nuclear	ADJ	JJ	Degree=Pos	_	_	_	_
37	export	export	NOUN	NN	Number=Sing	_	_	_	_
38	receptor	receptor	NOUN	NN	Number=Sing	_	_	_	_
39	CRM1	Crm1	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
40	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2529
# text = We have now used this assay to identify another export factor.
1	We	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
2	have	have	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
3	now	now	ADV	RB	_	_	_	_	_
4	used	use	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
5	this	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
6	assay	assay	NOUN	NN	Number=Sing	_	_	_	_
7	to	to	PART	TO	_	_	_	_	_
8	identify	identify	VERB	VB	VerbForm=Inf	_	_	_	_
9	another	another	DET	DT	_	_	_	_	_
10	export	export	NOUN	NN	Number=Sing	_	_	_	_
11	factor	factor	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
12	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2530
# text = After preincubation of permeabilized cells with a Ran mutant that cannot hydrolyze GTP (RanQ69L), cytosol supports NFAT export, but CRM1 and Ran alone do not.
1	After	after	ADP	IN	_	_	_	_	_
2	preincubation	preincubation	NOUN	NN	Number=Sing	_	_	_	_
3	of	of	ADP	IN	_	_	_	_	_
4	permeabilized	permeabilize	ADJ	JJ	Degree=Pos	_	_	_	_
5	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
6	with	with	ADP	IN	_	_	_	_	_
7	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
8	Ran	ran	PROPN	NNP	Number=Sing	_	_	_	_
9	mutant	mutant	NOUN	NN	Number=Sing	_	_	_	_
10	that	that	PRON	WDT	PronType=Rel	_	_	_	_
11	can	can	AUX	MD	VerbForm=Fin	_	_	_	SpaceAfter=No
12	not	not	PART	RB	_	_	_	_	_
13	hydrolyze	hydrolyze	VERB	VB	VerbForm=Inf	_	_	_	_
14	GTP	GTP	PROPN	NNP	Number=Sing	_	_	_	_
15	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
16	RanQ69L	RanQ69L	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
17	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
18	,	,	PUNCT	,	_	_	_	_	_
19	cytosol	cytosol	NOUN	NN	Number=Sing	_	_	_	_
20	supports	support	NOUN	NNS	Number=Plur	_	_	_	_
21	NFAT	Nfat	PRON	WDT	PronType=Rel	_	_	_	_
22	export	export	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	SpaceAfter=No
23	,	,	PUNCT	,	_	_	_	_	_
24	but	but	CCONJ	CC	_	_	_	_	_
25	CRM1	CRM1	PROPN	NNP	Number=Sing	_	_	_	_
26	and	and	CCONJ	CC	_	_	_	_	_
27	Ran	ran	PROPN	NNP	Number=Sing	_	_	_	_
28	alone	alone	ADV	RB	_	_	_	_	_
29	do	do	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
30	not	not	PART	RB	_	_	_	_	SpaceAfter=No
31	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2531
# text = The RanQ69L preincubation leads to accumulation of CRM1 at the cytoplasmic periphery of the nuclear pore complex (NPC) in association with the p62 complex and Can/Nup214.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	RanQ69L	Ranq69l	PROPN	NNP	Number=Sing	_	_	_	_
3	preincubation	preincubation	NOUN	NN	Number=Sing	_	_	_	_
4	leads	lead	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
5	to	to	PART	TO	_	_	_	_	_
6	accumulation	accumulation	VERB	VB	VerbForm=Inf	_	_	_	_
7	of	of	ADP	IN	_	_	_	_	_
8	CRM1	CRM1	NOUN	NN	Number=Sing	_	_	_	_
9	at	at	ADP	IN	_	_	_	_	_
10	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
11	cytoplasmic	cytoplasmic	ADJ	JJ	Degree=Pos	_	_	_	_
12	periphery	periphery	NOUN	NN	Number=Sing	_	_	_	_
13	of	of	ADP	IN	_	_	_	_	_
14	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
15	nuclear	nuclear	ADJ	JJ	Degree=Pos	_	_	_	_
16	pore	pore	NOUN	NN	Number=Sing	_	_	_	_
17	complex	complex	NOUN	NN	Number=Sing	_	_	_	_
18	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
19	NPC	NPC	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
20	)	)	PUNCT	-RRB-	_	_	_	_	_
21	in	in	ADP	IN	_	_	_	_	_
22	association	association	NOUN	NN	Number=Sing	_	_	_	_
23	with	with	ADP	IN	_	_	_	_	_
24	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
25	p62	p62	NOUN	NN	Number=Sing	_	_	_	_
26	complex	complex	NOUN	NN	Number=Sing	_	_	_	_
27	and	and	CCONJ	CC	_	_	_	_	_
28	Can	Can	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
29	/	/	PUNCT	,	_	_	_	_	SpaceAfter=No
30	Nup214	Nup214	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
31	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2532
# text = RanGTP-dependent association of CRM1 with these nucleoporins was reconstituted in vitro.
1	RanGTP-	RanGTP-	SYM	NFP	_	_	_	_	SpaceAfter=No
2	dependent	dependent	ADJ	JJ	Degree=Pos	_	_	_	_
3	association	association	NOUN	NN	Number=Sing	_	_	_	_
4	of	of	ADP	IN	_	_	_	_	_
5	CRM1	CRM1	PROPN	NNP	Number=Sing	_	_	_	_
6	with	with	ADP	IN	_	_	_	_	_
7	these	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
8	nucleoporins	nucleoporin	NOUN	NNS	Number=Plur	_	_	_	_
9	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
10	reconstituted	reconstitute	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
11	in	in	ADP	IN	_	_	_	_	_
12	vitro	vitro	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
13	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2533
# text = By biochemical fractionation and reconstitution, we showed that RanBP1 restores nuclear export after the RanQ69L preincubation.
1	By	by	ADP	IN	_	_	_	_	_
2	biochemical	biochemical	ADJ	JJ	Degree=Pos	_	_	_	_
3	fractionation	fractionation	NOUN	NN	Number=Sing	_	_	_	_
4	and	and	CCONJ	CC	_	_	_	_	_
5	reconstitution	reconstitution	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
6	,	,	PUNCT	,	_	_	_	_	_
7	we	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
8	showed	show	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
9	that	that	SCONJ	IN	_	_	_	_	_
10	RanBP1	RanBP1	PROPN	NNP	Number=Sing	_	_	_	_
11	restores	restore	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
12	nuclear	nuclear	ADJ	JJ	Degree=Pos	_	_	_	_
13	export	export	NOUN	NN	Number=Sing	_	_	_	_
14	after	after	ADP	IN	_	_	_	_	_
15	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
16	RanQ69L	Ranq69l	NOUN	NN	Number=Sing	_	_	_	_
17	preincubation	preincubation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
18	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2534
# text = It also stimulates nuclear export in cells that have not been preincubated with RanQ69L.
1	It	it	PRON	PRP	Case=Nom|Gender=Neut|Number=Sing|Person=3|PronType=Prs	_	_	_	_
2	also	also	ADV	RB	_	_	_	_	_
3	stimulates	stimulate	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
4	nuclear	nuclear	ADJ	JJ	Degree=Pos	_	_	_	_
5	export	export	NOUN	NN	Number=Sing	_	_	_	_
6	in	in	ADP	IN	_	_	_	_	_
7	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
8	that	that	PRON	WDT	PronType=Rel	_	_	_	_
9	have	have	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
10	not	not	PART	RB	_	_	_	_	_
11	been	be	AUX	VBN	Tense=Past|VerbForm=Part	_	_	_	_
12	preincubated	preincubate	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
13	with	with	ADP	IN	_	_	_	_	_
14	RanQ69L	Ranq69l	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
15	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2535
# text = RanBP1 as well as Ran-binding domains of the cytoplasmic nucleoporin RanBP2 promote the release of CRM1 from the NPC.
1	RanBP1	Ranbp1	NOUN	NN	Number=Sing	_	_	_	_
2	as	as	ADV	RB	_	_	_	_	_
3	well	well	ADV	RB	Degree=Pos	_	_	_	_
4	as	as	ADP	IN	_	_	_	_	_
5	Ran	ran	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
6	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
7	binding	bind	VERB	VBG	VerbForm=Ger	_	_	_	_
8	domains	domain	NOUN	NNS	Number=Plur	_	_	_	_
9	of	of	ADP	IN	_	_	_	_	_
10	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
11	cytoplasmic	cytoplasmic	ADJ	JJ	Degree=Pos	_	_	_	_
12	nucleoporin	nucleoporin	NOUN	NN	Number=Sing	_	_	_	_
13	RanBP2	Ranbp2	PART	TO	Abbr=Yes	_	_	_	_
14	promote	promote	VERB	VB	VerbForm=Inf	_	_	_	_
15	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
16	release	release	NOUN	NN	Number=Sing	_	_	_	_
17	of	of	ADP	IN	_	_	_	_	_
18	CRM1	Crm1	PROPN	NNP	Number=Sing	_	_	_	_
19	from	from	ADP	IN	_	_	_	_	_
20	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
21	NPC	Npc	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
22	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2536
# text = Taken together, our results indicate that RanGTP is important for the targeting of export complexes to the cytoplasmic side of the NPC and that RanBP1 and probably RanBP2 are involved in the dissociation of nuclear export complexes from the NPC in a terminal step of transport.
1	Taken	take	PROPN	NNP	Number=Sing	_	_	_	_
2	together	together	ADV	RB	_	_	_	_	SpaceAfter=No
3	,	,	PUNCT	,	_	_	_	_	_
4	our	we	PRON	PRP$	Number=Plur|Person=1|Poss=Yes|PronType=Prs	_	_	_	_
5	results	result	NOUN	NNS	Number=Plur	_	_	_	_
6	indicate	indicate	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
7	that	that	SCONJ	IN	_	_	_	_	_
8	RanGTP	RanGTP	PROPN	NNP	Number=Sing	_	_	_	_
9	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
10	important	important	ADJ	JJ	Degree=Pos	_	_	_	_
11	for	for	ADP	IN	_	_	_	_	_
12	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
13	targeting	targeting	NOUN	NN	Number=Sing	_	_	_	_
14	of	of	ADP	IN	_	_	_	_	_
15	export	export	NOUN	NN	Number=Sing	_	_	_	_
16	complexes	complex	NOUN	NNS	Number=Plur	_	_	_	_
17	to	to	ADP	IN	_	_	_	_	_
18	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
19	cytoplasmic	cytoplasmic	ADJ	JJ	Degree=Pos	_	_	_	_
20	side	side	NOUN	NN	Number=Sing	_	_	_	_
21	of	of	ADP	IN	_	_	_	_	_
22	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
23	NPC	NPC	PROPN	NNP	Number=Sing	_	_	_	_
24	and	and	CCONJ	CC	_	_	_	_	_
25	that	that	SCONJ	IN	_	_	_	_	_
26	RanBP1	RanBP1	PROPN	NNP	Number=Sing	_	_	_	_
27	and	and	CCONJ	CC	_	_	_	_	_
28	probably	probably	ADV	RB	_	_	_	_	_
29	RanBP2	Ranbp2	NOUN	NN	Number=Sing	_	_	_	_
30	are	be	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
31	involved	involved	ADJ	JJ	Degree=Pos	_	_	_	_
32	in	in	ADP	IN	_	_	_	_	_
33	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
34	dissociation	dissociation	NOUN	NN	Number=Sing	_	_	_	_
35	of	of	ADP	IN	_	_	_	_	_
36	nuclear	nuclear	ADJ	JJ	Degree=Pos	_	_	_	_
37	export	export	NOUN	NN	Number=Sing	_	_	_	_
38	complexes	complex	NOUN	NNS	Number=Plur	_	_	_	_
39	from	from	ADP	IN	_	_	_	_	_
40	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
41	NPC	NPC	PROPN	NNP	Number=Sing	_	_	_	_
42	in	in	ADP	IN	_	_	_	_	_
43	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
44	terminal	terminal	ADJ	JJ	Degree=Pos	_	_	_	_
45	step	step	NOUN	NN	Number=Sing	_	_	_	_
46	of	of	ADP	IN	_	_	_	_	_
47	transport	transport	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
48	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 2537
# text = Document 003003265 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	003003265	003003265	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 2538
# text = 1,25-Dihydroxyvitamin D3 receptor RNA: expression in hematopoietic cells.
1	1,25	1,25	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
2	-	-	PUNCT	:	_	_	_	_	SpaceAfter=No
3	Dihydroxyvitamin	Dihydroxyvitamin	NOUN	NN	Number=Sing	_	_	_	_
4	D3	D3	NOUN	NN	Number=Sing	_	_	_	_
5	receptor	receptor	NOUN	NN	Number=Sing	_	_	_	_
6	RNA	RNa	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
7	:	:	PUNCT	:	_	_	_	_	_
8	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
9	in	in	ADP	IN	_	_	_	_	_
10	hematopoietic	hematopoietic	ADJ	JJ	Degree=Pos	_	_	_	_
11	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
12	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 2539
# text = 1,25-Dihydroxyvitamin D3 [1,25(OH)2D3] induces differentiation and inhibits proliferation of myeloid leukemic cells from various lines and patients; these effects are probably mediated through the 1,25(OH)2D3 receptor.
1	1,25	1,25	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
2	-	-	PUNCT	:	_	_	_	_	SpaceAfter=No
3	Dihydroxyvitamin	Dihydroxyvitamin	NOUN	NN	Number=Sing	_	_	_	_
4	D3	D3	NOUN	NN	Number=Sing	_	_	_	_
5	[	[	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
6	1,25	1,25	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
7	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
8	OH	Oh	INTJ	UH	_	_	_	_	SpaceAfter=No
9	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
10	2D3	2D3	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
11	]	]	PUNCT	-RRB-	_	_	_	_	_
12	induces	induce	NOUN	NNS	Number=Plur	_	_	_	_
13	differentiation	differentiation	NOUN	NN	Number=Sing	_	_	_	_
14	and	and	CCONJ	CC	_	_	_	_	_
15	inhibits	inhibits	NOUN	NNS	Number=Plur	_	_	_	_
16	proliferation	proliferation	NOUN	NN	Number=Sing	_	_	_	_
17	of	of	ADP	IN	_	_	_	_	_
18	myeloid	myeloid	ADJ	JJ	Degree=Pos	_	_	_	_
19	leukemic	leukemic	ADJ	JJ	Degree=Pos	_	_	_	_
20	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
21	from	from	ADP	IN	_	_	_	_	_
22	various	various	ADJ	JJ	Degree=Pos	_	_	_	_
23	lines	line	NOUN	NNS	Number=Plur	_	_	_	_
24	and	and	CCONJ	CC	_	_	_	_	_
25	patients	patient	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
26	;	;	PUNCT	,	_	_	_	_	_
27	these	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
28	effects	effect	NOUN	NNS	Number=Plur	_	_	_	_
29	are	be	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
30	probably	probably	ADV	RB	_	_	_	_	_
31	mediated	mediate	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
32	through	through	ADP	IN	_	_	_	_	_
33	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
34	1,25	1,25	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
35	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
36	OH	oh	INTJ	UH	_	_	_	_	SpaceAfter=No
37	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
38	2D3	2D3	NUM	CD	NumType=Card	_	_	_	_
39	receptor	receptor	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
40	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2540
# text = Little is known of expression of 1,25(OH)2D3 receptor RNA in hematopoietic cells.
1	Little	little	PROPN	NNP	Number=Sing	_	_	_	_
2	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
3	known	know	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
4	of	of	ADP	IN	_	_	_	_	_
5	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
6	of	of	ADP	IN	_	_	_	_	_
7	1,25	1,25	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
8	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
9	OH	oh	INTJ	UH	_	_	_	_	SpaceAfter=No
10	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
11	2D3	2D3	NUM	CD	NumType=Card	_	_	_	_
12	receptor	receptor	NOUN	NN	Number=Sing	_	_	_	_
13	RNA	RNa	PROPN	NNP	Number=Sing	_	_	_	_
14	in	in	ADP	IN	_	_	_	_	_
15	hematopoietic	hematopoietic	ADJ	JJ	Degree=Pos	_	_	_	_
16	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
17	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2541
# text = We examined the expression and modulation of expression of 1,25(OH)2D3 receptor RNA in various proliferating and nonproliferating hematopoietic cells.
1	We	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
2	examined	examin	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
3	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
4	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
5	and	and	CCONJ	CC	_	_	_	_	_
6	modulation	modulation	NOUN	NN	Number=Sing	_	_	_	_
7	of	of	ADP	IN	_	_	_	_	_
8	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
9	of	of	ADP	IN	_	_	_	_	_
10	1,25	1,25	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
11	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
12	OH	oh	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
13	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
14	2D3	2D3	NUM	CD	NumType=Card	_	_	_	_
15	receptor	receptor	NOUN	NN	Number=Sing	_	_	_	_
16	RNA	RNa	NOUN	NN	Number=Sing	_	_	_	_
17	in	in	ADP	IN	_	_	_	_	_
18	various	various	ADJ	JJ	Degree=Pos	_	_	_	_
19	proliferating	proliferating	NOUN	NN	Number=Sing	_	_	_	_
20	and	and	CCONJ	CC	_	_	_	_	_
21	nonproliferating	nonproliferat	VERB	VBG	VerbForm=Ger	_	_	_	_
22	hematopoietic	hematopoietic	ADJ	JJ	Degree=Pos	_	_	_	_
23	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
24	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2542
# text = Constitutive expression of 1,25(OH)2D3 receptor
1	Constitutive	Constitutive	ADJ	JJ	Degree=Pos	_	_	_	_
2	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
3	of	of	ADP	IN	_	_	_	_	_
4	1,25	1,25	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
5	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
6	OH	Oh	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
7	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
8	2D3	2D3	NUM	CD	NumType=Card	_	_	_	_
9	receptor	receptor	NOUN	NN	Number=Sing	_	_	_	_

# sent_id = 2543
# text = RNA was detected in various kinds of hematopoietic cells, including macrophages and activated T lymphocytes, as well as in cell lines KG-1 (myeloblasts), HL-60 (promyelocytes), ML-3 (myelomonoblasts), U937, THP-1 (monoblasts), K562 (erythroblasts), and S-LB1 (HTLV-1-transfected T lymphocytes).
1	RNA	RNa	PROPN	NNP	Number=Sing	_	_	_	_
2	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
3	detected	detect	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
4	in	in	ADP	IN	_	_	_	_	_
5	various	various	ADJ	JJ	Degree=Pos	_	_	_	_
6	kinds	kind	NOUN	NNS	Number=Plur	_	_	_	_
7	of	of	ADP	IN	_	_	_	_	_
8	hematopoietic	hematopoietic	ADJ	JJ	Degree=Pos	_	_	_	_
9	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
10	,	,	PUNCT	,	_	_	_	_	_
11	including	include	VERB	VBG	VerbForm=Ger	_	_	_	_
12	macrophages	macrophage	NOUN	NNS	Number=Plur	_	_	_	_
13	and	and	CCONJ	CC	_	_	_	_	_
14	activated	activate	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
15	T	t	PROPN	NNP	Number=Sing	_	_	_	_
16	lymphocytes	lymphocyte	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
17	,	,	PUNCT	,	_	_	_	_	_
18	as	as	ADV	RB	_	_	_	_	_
19	well	well	ADV	RB	Degree=Pos	_	_	_	_
20	as	as	ADP	IN	_	_	_	_	_
21	in	in	ADP	IN	_	_	_	_	_
22	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
23	lines	line	NOUN	NNS	Number=Plur	_	_	_	_
24	KG	kg	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
25	-	-	SYM	SYM	_	_	_	_	SpaceAfter=No
26	1	1	NUM	CD	NumType=Card	_	_	_	_
27	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
28	myeloblasts	myeloblast	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
29	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
30	,	,	PUNCT	,	_	_	_	_	_
31	HL	HL	SYM	$	_	_	_	_	SpaceAfter=No
32	-	-	SYM	SYM	_	_	_	_	SpaceAfter=No
33	60	60	NUM	CD	NumType=Card	_	_	_	_
34	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
35	promyelocytes	promyelocyte	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
36	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
37	,	,	PUNCT	,	_	_	_	_	_
38	ML	ML	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
39	-	-	SYM	SYM	_	_	_	_	SpaceAfter=No
40	3	3	NUM	CD	NumType=Card	_	_	_	_
41	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
42	myelomonoblasts	myelomonoblast	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
43	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
44	,	,	PUNCT	,	_	_	_	_	_
45	U937	U937	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
46	,	,	PUNCT	,	_	_	_	_	_
47	THP	Thp	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
48	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
49	1	1	NUM	CD	NumType=Card	_	_	_	_
50	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
51	monoblasts	monoblast	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
52	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
53	,	,	PUNCT	,	_	_	_	_	_
54	K562	K562	NUM	CD	NumType=Card	_	_	_	_
55	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
56	erythroblasts	erythroblast	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
57	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
58	,	,	PUNCT	,	_	_	_	_	_
59	and	and	CCONJ	CC	_	_	_	_	_
60	S-	S-	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
61	LB	lb	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
62	1	1	NUM	CD	NumType=Card	_	_	_	_
63	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
64	HTLV	Htlv	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
65	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
66	1	1	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
67	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
68	transfected	transfect	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
69	T	t	PROPN	NNP	Number=Sing	_	_	_	_
70	lymphocytes	lymphocyte	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
71	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
72	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2544
# text = Receptor transcripts were 4.6 kilobases (kb), and no variant sizes were observed.
1	Receptor	Receptor	NOUN	NN	Number=Sing	_	_	_	_
2	transcripts	transcript	NOUN	NNS	Number=Plur	_	_	_	_
3	were	be	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
4	4.6	4.6	NUM	CD	NumType=Card	_	_	_	_
5	kilobases	kilobase	NOUN	NNS	Number=Plur	_	_	_	_
6	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
7	kb	kb	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
8	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
9	,	,	PUNCT	,	_	_	_	_	_
10	and	and	CCONJ	CC	_	_	_	_	_
11	no	no	DET	DT	_	_	_	_	_
12	variant	variant	NOUN	NN	Number=Sing	_	_	_	_
13	sizes	size	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
14	were	be	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
15	observed	observe	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
16	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2545
# text = All cell lines examined in this group also expressed 1,25(OH)2D3 receptors.
1	All	all	DET	DT	_	_	_	_	_
2	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
3	lines	line	NOUN	NNS	Number=Plur	_	_	_	_
4	examined	examine	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
5	in	in	ADP	IN	_	_	_	_	_
6	this	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
7	group	group	NOUN	NN	Number=Sing	_	_	_	_
8	also	also	ADV	RB	_	_	_	_	_
9	expressed	express	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
10	1,25	1,25	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
11	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
12	OH	oh	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
13	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
14	2D3	2D3	NUM	CD	NumType=Card	_	_	_	_
15	receptors	receptor	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
16	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2546
# text = Most B lymphocyte lines expressed negligible levels of 1,25(OH)2D3 receptor
1	Most	most	ADJ	JJS	Degree=Sup	_	_	_	_
2	B	benefit	ADJ	JJ	Degree=Pos	_	_	_	_
3	lymphocyte	lymphocyte	NOUN	NN	Number=Sing	_	_	_	_
4	lines	line	NOUN	NNS	Number=Plur	_	_	_	_
5	expressed	express	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
6	negligible	negligible	ADJ	JJ	Degree=Pos	_	_	_	_
7	levels	level	NOUN	NNS	Number=Plur	_	_	_	_
8	of	of	ADP	IN	_	_	_	_	_
9	1,25	1,25	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
10	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
11	OH	Oh	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
12	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
13	2D3	2D3	NUM	CD	NumType=Card	_	_	_	_
14	receptor	receptor	NOUN	NN	Number=Sing	_	_	_	_

# sent_id = 2547
# text = RNA and protein; however; analysis of a lymphoid/myeloid somatic hybrid suggested that suppression of expression of 1,25(OH)2D3 receptor
1	RNA	RNa	PROPN	NNP	Number=Sing	_	_	_	_
2	and	and	CCONJ	CC	_	_	_	_	_
3	protein	protein	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
4	;	;	PUNCT	,	_	_	_	_	_
5	however	however	ADV	RB	_	_	_	_	SpaceAfter=No
6	;	;	PUNCT	,	_	_	_	_	_
7	analysis	analysis	NOUN	NN	Number=Sing	_	_	_	_
8	of	of	ADP	IN	_	_	_	_	_
9	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
10	lymphoid	lymphoid	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
11	/	/	PUNCT	,	_	_	_	_	SpaceAfter=No
12	myeloid	myeloid	ADJ	JJ	Degree=Pos	_	_	_	_
13	somatic	somatic	ADJ	JJ	Degree=Pos	_	_	_	_
14	hybrid	hybrid	NOUN	NN	Number=Sing	_	_	_	_
15	suggested	suggest	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
16	that	that	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
17	suppression	suppression	NOUN	NN	Number=Sing	_	_	_	_
18	of	of	ADP	IN	_	_	_	_	_
19	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
20	of	of	ADP	IN	_	_	_	_	_
21	1,25	1,25	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
22	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
23	OH	oh	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
24	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
25	2D3	2D3	NUM	CD	NumType=Card	_	_	_	_
26	receptor	receptor	NOUN	NN	Number=Sing	_	_	_	_

# sent_id = 2548
# text = RNA in B lymphocytes may be a dominant characteristic.
1	RNA	RNa	NOUN	NN	Number=Sing	_	_	_	_
2	in	in	ADP	IN	_	_	_	_	_
3	B	b	ADJ	JJ	Degree=Pos	_	_	_	_
4	lymphocytes	lymphocyte	NOUN	NNS	Number=Plur	_	_	_	_
5	may	may	AUX	MD	VerbForm=Fin	_	_	_	_
6	be	be	AUX	VB	VerbForm=Inf	_	_	_	_
7	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
8	dominant	dominant	ADJ	JJ	Degree=Pos	_	_	_	_
9	characteristic	characteristic	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
10	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2549
# text = HL-60 cells were cultured with 10(-7) mol/L 1,25(OH)2D3 for 24 to 72 hours, and levels of expression of 1,25(OH)2D3 receptor and its RNA were examined.
1	HL	Hl	INTJ	UH	_	_	_	_	SpaceAfter=No
2	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
3	60	60	NUM	CD	NumType=Card	_	_	_	_
4	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
5	were	be	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
6	cultured	culture	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
7	with	with	ADP	IN	_	_	_	_	_
8	10	10	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
9	(-	(-	PUNCT	.	_	_	_	_	SpaceAfter=No
10	7	7	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
11	)	)	PUNCT	-RRB-	_	_	_	_	_
12	mol/L	mol/l	NOUN	NN	Number=Sing	_	_	_	_
13	1,25	1,25	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
14	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
15	OH	oh	INTJ	UH	_	_	_	_	SpaceAfter=No
16	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
17	2D3	2D3	NUM	CD	NumType=Card	_	_	_	_
18	for	for	ADP	IN	_	_	_	_	_
19	24	24	NUM	CD	NumType=Card	_	_	_	_
20	to	to	ADP	IN	_	_	_	_	_
21	72	72	NUM	CD	NumType=Card	_	_	_	_
22	hours	hour	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
23	,	,	PUNCT	,	_	_	_	_	_
24	and	and	CCONJ	CC	_	_	_	_	_
25	levels	level	NOUN	NNS	Number=Plur	_	_	_	_
26	of	of	ADP	IN	_	_	_	_	_
27	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
28	of	of	ADP	IN	_	_	_	_	_
29	1,25	1,25	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
30	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
31	OH	oh	INTJ	UH	_	_	_	_	SpaceAfter=No
32	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
33	2D3	2D3	NUM	CD	NumType=Card	_	_	_	_
34	receptor	receptor	NOUN	NN	Number=Sing	_	_	_	_
35	and	and	CCONJ	CC	_	_	_	_	_
36	it	it	PRON	PRP	Case=Nom|Gender=Neut|Number=Sing|Person=3|PronType=Prs	_	_	_	SpaceAfter=No
37	s	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
38	RNA	RNA	PROPN	NNP	Number=Sing	_	_	_	_
39	were	be	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
40	examined	examin	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	SpaceAfter=No
41	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2550
# text = Levels of RNA coding for the receptor were not modulated by exposure to high levels of ligand.
1	Levels	level	NOUN	NNS	Number=Plur	_	_	_	_
2	of	of	ADP	IN	_	_	_	_	_
3	RNA	RNA	PROPN	NNP	Number=Sing	_	_	_	_
4	coding	code	VERB	VBG	VerbForm=Ger	_	_	_	_
5	for	for	ADP	IN	_	_	_	_	_
6	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
7	receptor	receptor	NOUN	NN	Number=Sing	_	_	_	_
8	were	be	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
9	not	not	PART	RB	_	_	_	_	_
10	modulated	modulate	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
11	by	by	ADP	IN	_	_	_	_	_
12	exposure	exposure	NOUN	NN	Number=Sing	_	_	_	_
13	to	to	ADP	IN	_	_	_	_	_
14	high	high	ADJ	JJ	Degree=Pos	_	_	_	_
15	levels	level	NOUN	NNS	Number=Plur	_	_	_	_
16	of	of	ADP	IN	_	_	_	_	_
17	ligand	ligand	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
18	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2551
# text = Levels of occupied 1,25(OH)2D3 receptor protein increased in these HL-60 cells; but the total number of 1,25(OH)2D3 receptors decreased about 50% at 24 hours and returned toward normal at 72 hours.
1	Levels	level	NOUN	NNS	Number=Plur	_	_	_	_
2	of	of	ADP	IN	_	_	_	_	_
3	occupied	occupied	ADJ	JJ	Degree=Pos	_	_	_	_
4	1,25	1,25	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
5	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
6	OH	Oh	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
7	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
8	2D3	2D3	NUM	CD	NumType=Card	_	_	_	_
9	receptor	receptor	NOUN	NN	Number=Sing	_	_	_	_
10	protein	protein	NOUN	NN	Number=Sing	_	_	_	_
11	increased	increase	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
12	in	in	ADP	IN	_	_	_	_	_
13	these	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
14	HL	HL	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
15	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
16	60	60	NUM	CD	NumType=Card	_	_	_	_
17	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
18	;	;	PUNCT	,	_	_	_	_	_
19	but	but	CCONJ	CC	_	_	_	_	_
20	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
21	total	total	ADJ	JJ	Degree=Pos	_	_	_	_
22	number	number	NOUN	NN	Number=Sing	_	_	_	_
23	of	of	ADP	IN	_	_	_	_	_
24	1,25	1,25	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
25	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
26	OH	Oh	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
27	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
28	2D3	2D3	NUM	CD	NumType=Card	_	_	_	_
29	receptors	receptor	NOUN	NNS	Number=Plur	_	_	_	_
30	decreased	decrease	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
31	about	about	ADV	RB	_	_	_	_	_
32	50	50	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
33	%	%	SYM	NN	Number=Sing	_	_	_	_
34	at	at	ADP	IN	_	_	_	_	_
35	24	24	NUM	CD	NumType=Card	_	_	_	_
36	hours	hour	NOUN	NNS	Number=Plur	_	_	_	_
37	and	and	CCONJ	CC	_	_	_	_	_
38	returned	return	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
39	toward	toward	ADP	IN	_	_	_	_	_
40	normal	normal	ADJ	JJ	Degree=Pos	_	_	_	_
41	at	at	ADP	IN	_	_	_	_	_
42	72	72	NUM	CD	NumType=Card	_	_	_	_
43	hours	hour	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
44	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2552
# text = Steady-state levels of 1,25(OH)2D3 receptor
1	Steady	steady	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
2	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
3	state	state	NOUN	NN	Number=Sing	_	_	_	_
4	levels	level	NOUN	NNS	Number=Plur	_	_	_	_
5	of	of	ADP	IN	_	_	_	_	_
6	1,25	1,25	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
7	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
8	OH	Oh	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
9	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
10	2D3	2D3	NUM	CD	NumType=Card	_	_	_	_
11	receptor	receptor	NOUN	NN	Number=Sing	_	_	_	_

# sent_id = 2553
# text = RNA were not affected by terminal differentiation of HL-60 toward either granulocytes or macrophages.
1	RNA	RNA	NOUN	NN	Number=Sing	_	_	_	_
2	were	be	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
3	not	not	PART	RB	_	_	_	_	_
4	affected	affect	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
5	by	by	ADP	IN	_	_	_	_	_
6	terminal	terminal	ADJ	JJ	Degree=Pos	_	_	_	_
7	differentiation	differentiation	NOUN	NN	Number=Sing	_	_	_	_
8	of	of	ADP	IN	_	_	_	_	_
9	HL	HL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
10	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
11	60	60	NUM	CD	NumType=Card	_	_	_	_
12	toward	toward	ADP	IN	_	_	_	_	_
13	either	either	DET	DT	_	_	_	_	_
14	granulocytes	granulocyte	NOUN	NNS	Number=Plur	_	_	_	_
15	or	or	CCONJ	CC	_	_	_	_	_
16	macrophages	macrophage	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
17	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2554
# text = Nondividing macrophages from normal individuals also expressed 1,25(OH)2D3 receptor RNA.
1	Nondividing	Nondivid	VERB	VBG	VerbForm=Ger	_	_	_	_
2	macrophages	macrophage	NOUN	NNS	Number=Plur	_	_	_	_
3	from	from	ADP	IN	_	_	_	_	_
4	normal	normal	ADJ	JJ	Degree=Pos	_	_	_	_
5	individuals	individual	NOUN	NNS	Number=Plur	_	_	_	_
6	also	also	ADV	RB	_	_	_	_	_
7	expressed	express	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
8	1,25	1,25	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
9	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
10	OH	Oh	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
11	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
12	2D3	2D3	NUM	CD	NumType=Card	_	_	_	_
13	receptor	receptor	NOUN	NN	Number=Sing	_	_	_	_
14	RNA	RNA	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
15	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2555
# text = In contrast, nondividing peripheral blood lymphocytes from normal individuals did not express 1,25(OH)2D3 receptor RNA; with stimulation of proliferation of these cells, accumulation of 1,25(OH)2D3 receptor RNA increased markedly.
1	In	in	ADP	IN	_	_	_	_	_
2	contrast	contrast	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
3	,	,	PUNCT	,	_	_	_	_	_
4	nondividing	nondivid	VERB	VBG	VerbForm=Ger	_	_	_	_
5	peripheral	peripheral	ADJ	JJ	Degree=Pos	_	_	_	_
6	blood	blood	NOUN	NN	Number=Sing	_	_	_	_
7	lymphocytes	lymphocyte	NOUN	NNS	Number=Plur	_	_	_	_
8	from	from	ADP	IN	_	_	_	_	_
9	normal	normal	ADJ	JJ	Degree=Pos	_	_	_	_
10	individuals	individual	NOUN	NNS	Number=Plur	_	_	_	_
11	did	do	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
12	not	not	PART	RB	_	_	_	_	_
13	express	express	VERB	VB	VerbForm=Inf	_	_	_	_
14	1,25	1,25	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
15	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
16	OH	oh	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
17	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
18	2D3	2D3	NUM	CD	NumType=Card	_	_	_	_
19	receptor	receptor	NOUN	NN	Number=Sing	_	_	_	_
20	RNA	RNa	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
21	;	;	PUNCT	,	_	_	_	_	_
22	with	with	ADP	IN	_	_	_	_	_
23	stimulation	stimulation	NOUN	NN	Number=Sing	_	_	_	_
24	of	of	ADP	IN	_	_	_	_	_
25	proliferation	proliferation	NOUN	NN	Number=Sing	_	_	_	_
26	of	of	ADP	IN	_	_	_	_	_
27	these	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
28	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
29	,	,	PUNCT	,	_	_	_	_	_
30	accumulation	accumulation	NOUN	NN	Number=Sing	_	_	_	_
31	of	of	ADP	IN	_	_	_	_	_
32	1,25	1,25	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
33	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
34	OH	oh	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
35	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
36	2D3	2D3	NUM	CD	NumType=Card	_	_	_	_
37	receptor	receptor	NOUN	NN	Number=Sing	_	_	_	_
38	RNA	RNa	SYM	SYM	_	_	_	_	_
39	increased	increase	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
40	markedly	markedly	ADV	RB	_	_	_	_	SpaceAfter=No
41	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2556
# text = Half-life (t1/2) of 1,25(OH)2D3 receptor
1	Half	half	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
2	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
3	life	life	NOUN	NN	Number=Sing	_	_	_	_
4	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
5	t1/2	t1/2	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
6	)	)	PUNCT	-RRB-	_	_	_	_	_
7	of	of	ADP	IN	_	_	_	_	_
8	1,25	1,25	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
9	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
10	OH	Oh	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
11	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
12	2D3	2D3	NUM	CD	NumType=Card	_	_	_	_
13	receptor	receptor	NOUN	NN	Number=Sing	_	_	_	_

# sent_id = 2557
# text = RNA in T lymphocytes was short (1 hour) as determined by measuring decay of the message after addition of actinomycin D. Consistent with this short t1/2, accumulation of 1,25(OH)2D3 receptor RNA increased in cells as their protein synthesis was inhibited.
1	RNA	RNA	PROPN	NNP	Number=Sing	_	_	_	_
2	in	in	ADP	IN	_	_	_	_	_
3	T	t	PROPN	NNP	Number=Sing	_	_	_	_
4	lymphocytes	lymphocyte	NOUN	NNS	Number=Plur	_	_	_	_
5	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
6	short	short	ADJ	JJ	Degree=Pos	_	_	_	_
7	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
8	1	1	NUM	CD	NumType=Card	_	_	_	_
9	hour	hour	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
10	)	)	PUNCT	-RRB-	_	_	_	_	_
11	as	as	ADV	RB	_	_	_	_	_
12	determined	determine	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
13	by	by	SCONJ	IN	_	_	_	_	_
14	measuring	measure	VERB	VBG	VerbForm=Ger	_	_	_	_
15	decay	decay	NOUN	NN	Number=Sing	_	_	_	_
16	of	of	ADP	IN	_	_	_	_	_
17	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
18	message	message	NOUN	NN	Number=Sing	_	_	_	_
19	after	after	ADP	IN	_	_	_	_	_
20	addition	addition	NOUN	NN	Number=Sing	_	_	_	_
21	of	of	ADP	IN	_	_	_	_	_
22	actinomycin	actinomycin	ADP	IN	_	_	_	_	_
23	D.	D.	PROPN	NNP	Number=Sing	_	_	_	_
24	Consistent	consistent	PROPN	NNP	Number=Sing	_	_	_	_
25	with	with	ADP	IN	_	_	_	_	_
26	this	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
27	short	short	ADJ	JJ	Degree=Pos	_	_	_	_
28	t1/2	t1/2	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
29	,	,	PUNCT	,	_	_	_	_	_
30	accumulation	accumulation	NOUN	NN	Number=Sing	_	_	_	_
31	of	of	ADP	IN	_	_	_	_	_
32	1,25	1,25	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
33	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
34	OH	oh	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
35	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
36	2D3	2D3	NUM	CD	NumType=Card	_	_	_	_
37	receptor	receptor	NOUN	NN	Number=Sing	_	_	_	_
38	RNA	RNa	PROPN	NNP	Number=Sing	_	_	_	_
39	increased	increase	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
40	in	in	ADP	IN	_	_	_	_	_
41	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
42	as	as	ADP	IN	_	_	_	_	_
43	their	they	PRON	PRP$	Number=Plur|Person=3|Poss=Yes|PronType=Prs	_	_	_	_
44	protein	protein	NOUN	NN	Number=Sing	_	_	_	_
45	synthesis	synthesis	NOUN	NN	Number=Sing	_	_	_	_
46	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
47	inhibited	inhibit	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	SpaceAfter=No
48	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2558
# text = Further studies are required to understand the physiologic role of 1,25(OH)2D3 receptors in myeloid cells and proliferating T lymphocytes.
1	Further	further	ADJ	JJ	Degree=Pos	_	_	_	_
2	studies	study	NOUN	NNS	Number=Plur	_	_	_	_
3	are	be	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
4	required	require	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
5	to	to	PART	TO	_	_	_	_	_
6	understand	understand	VERB	VB	VerbForm=Inf	_	_	_	_
7	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
8	physiologic	physiologic	NOUN	NN	Number=Sing	_	_	_	_
9	role	role	NOUN	NN	Number=Sing	_	_	_	_
10	of	of	ADP	IN	_	_	_	_	_
11	1,25	1,25	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
12	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
13	OH	oh	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
14	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
15	2D3	2D3	NUM	CD	NumType=Card	_	_	_	_
16	receptors	receptor	NOUN	NNS	Number=Plur	_	_	_	_
17	in	in	ADP	IN	_	_	_	_	_
18	myeloid	myeloid	ADJ	JJ	Degree=Pos	_	_	_	_
19	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
20	and	and	CCONJ	CC	_	_	_	_	_
21	proliferating	proliferat	VERB	VBG	VerbForm=Ger	_	_	_	_
22	T	t	PROPN	NNP	Number=Sing	_	_	_	_
23	lymphocytes	lymphocyte	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
24	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 2559
# text = Document 003003267 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	003003267	003003267	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 2560
# text = Interleukin-2 induces tyrosine phosphorylation and nuclear translocation of stat3 in human T lymphocytes.
1	Interleukin	Interleukin	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
2	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
3	2	2	NUM	CD	NumType=Card	_	_	_	_
4	induces	induce	NOUN	NNS	Number=Plur	_	_	_	_
5	tyrosine	tyrosine	NOUN	NN	Number=Sing	_	_	_	_
6	phosphorylation	phosphorylation	NOUN	NN	Number=Sing	_	_	_	_
7	and	and	CCONJ	CC	_	_	_	_	_
8	nuclear	nuclear	ADJ	JJ	Degree=Pos	_	_	_	_
9	translocation	translocation	NOUN	NN	Number=Sing	_	_	_	_
10	of	of	ADP	IN	_	_	_	_	_
11	stat3	stat3	NOUN	NN	Number=Sing	_	_	_	_
12	in	in	ADP	IN	_	_	_	_	_
13	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
14	T	t	PROPN	NNP	Number=Sing	_	_	_	_
15	lymphocytes	lymphocyte	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
16	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 2561
# text = An early biochemical event associated with T cell activation through the interleukin-2 receptor (IL-2R) is tyrosine phosphorylation of several intracellular substrates.
1	An	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
2	early	early	ADJ	JJ	Degree=Pos	_	_	_	_
3	biochemical	biochemical	ADJ	JJ	Degree=Pos	_	_	_	_
4	event	event	NOUN	NN	Number=Sing	_	_	_	_
5	associated	associate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
6	with	with	ADP	IN	_	_	_	_	_
7	T	t	PROPN	NNP	Number=Sing	_	_	_	_
8	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
9	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
10	through	through	ADP	IN	_	_	_	_	_
11	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
12	interleukin	interleukin	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
13	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
14	2	2	NUM	CD	NumType=Card	_	_	_	_
15	receptor	receptor	NOUN	NN	Number=Sing	_	_	_	_
16	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
17	IL	Il	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
18	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
19	2R	2r	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
20	)	)	PUNCT	-RRB-	_	_	_	_	_
21	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
22	tyrosine	tyrosine	NOUN	NN	Number=Sing	_	_	_	_
23	phosphorylation	phosphorylation	NOUN	NN	Number=Sing	_	_	_	_
24	of	of	ADP	IN	_	_	_	_	_
25	several	several	ADJ	JJ	Degree=Pos	_	_	_	_
26	intracellular	intracellular	ADJ	JJ	Degree=Pos	_	_	_	_
27	substrates	substrate	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
28	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2562
# text = The exact mechanism by which IL-2 regulates transcription of different genes is presently unknown.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	exact	exact	ADJ	JJ	Degree=Pos	_	_	_	_
3	mechanism	mechanism	NOUN	NN	Number=Sing	_	_	_	_
4	by	by	ADP	IN	_	_	_	_	_
5	which	which	PRON	WDT	PronType=Rel	_	_	_	_
6	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
7	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
8	2	2	NUM	CD	NumType=Card	_	_	_	_
9	regulates	regulate	NOUN	NNS	Number=Plur	_	_	_	_
10	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
11	of	of	ADP	IN	_	_	_	_	_
12	different	different	ADJ	JJ	Degree=Pos	_	_	_	_
13	genes	gene	NOUN	NNS	Number=Plur	_	_	_	_
14	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
15	presently	presently	ADV	RB	_	_	_	_	_
16	unknown	unknown	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
17	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2563
# text = Here, we report that stimulation through the IL-2R induced tyrosine phosphorylation and subsequent nuclear translocation of stat3, a newly identified member of the signal transducers and activators of transcription (STAT) family of proteins.
1	Here	here	ADV	RB	PronType=Dem	_	_	_	SpaceAfter=No
2	,	,	PUNCT	,	_	_	_	_	_
3	we	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
4	report	report	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
5	that	that	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
6	stimulation	stimulation	NOUN	NN	Number=Sing	_	_	_	_
7	through	through	ADP	IN	_	_	_	_	_
8	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
9	IL	Il	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
10	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
11	2	2	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
12	R	be	ADP	IN	_	_	_	_	_
13	induced	induce	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
14	tyrosine	tyrosine	NOUN	NN	Number=Sing	_	_	_	_
15	phosphorylation	phosphorylation	NOUN	NN	Number=Sing	_	_	_	_
16	and	and	CCONJ	CC	_	_	_	_	_
17	subsequent	subsequent	ADJ	JJ	Degree=Pos	_	_	_	_
18	nuclear	nuclear	ADJ	JJ	Degree=Pos	_	_	_	_
19	translocation	translocation	NOUN	NN	Number=Sing	_	_	_	_
20	of	of	ADP	IN	_	_	_	_	_
21	stat3	stat3	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
22	,	,	PUNCT	,	_	_	_	_	_
23	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
24	newly	newly	ADV	RB	_	_	_	_	_
25	identified	identify	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
26	member	member	NOUN	NN	Number=Sing	_	_	_	_
27	of	of	ADP	IN	_	_	_	_	_
28	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
29	signal	signal	ADJ	JJ	Degree=Pos	_	_	_	_
30	transducers	transducer	NOUN	NNS	Number=Plur	_	_	_	_
31	and	and	CCONJ	CC	_	_	_	_	_
32	activators	activator	NOUN	NNS	Number=Plur	_	_	_	_
33	of	of	ADP	IN	_	_	_	_	_
34	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
35	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
36	STAT	STAT	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
37	)	)	PUNCT	-RRB-	_	_	_	_	_
38	family	family	NOUN	NN	Number=Sing	_	_	_	_
39	of	of	ADP	IN	_	_	_	_	_
40	proteins	protein	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
41	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2564
# text = In contrast, stat1 proteins were not tyrosine phosphorylated after IL-2 ligation, whereas tyrosine-phosphorylated stat1 proteins (91 and 84 kDa proteins) were translocated to the nucleus following interferon-gamma treatment of HeLa cells.
1	In	in	ADP	IN	_	_	_	_	_
2	contrast	contrast	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
3	,	,	PUNCT	,	_	_	_	_	_
4	stat1	stat1	NUM	CD	NumType=Card	_	_	_	_
5	proteins	protein	NOUN	NNS	Number=Plur	_	_	_	_
6	were	be	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
7	not	not	PART	RB	_	_	_	_	_
8	tyrosine	tyrosine	ADV	RB	_	_	_	_	_
9	phosphorylated	phosphorylate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
10	after	after	ADP	IN	_	_	_	_	_
11	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
12	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
13	2	2	NUM	CD	NumType=Card	_	_	_	_
14	ligation	ligation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
15	,	,	PUNCT	,	_	_	_	_	_
16	whereas	whereas	SCONJ	IN	_	_	_	_	_
17	tyrosine	tyrosine	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
18	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
19	phosphorylated	phosphorylate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
20	stat1	stat1	NOUN	NN	Number=Sing	_	_	_	_
21	proteins	protein	NOUN	NNS	Number=Plur	_	_	_	_
22	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
23	91	91	NUM	CD	NumType=Card	_	_	_	_
24	and	and	CCONJ	CC	_	_	_	_	_
25	84	84	NUM	CD	NumType=Card	_	_	_	_
26	kDa	kDa	PROPN	NNP	Number=Sing	_	_	_	_
27	proteins	protein	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
28	)	)	PUNCT	-RRB-	_	_	_	_	_
29	were	be	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
30	translocated	translocate	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
31	to	to	ADP	IN	_	_	_	_	_
32	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
33	nucleus	nucleus	NOUN	NN	Number=Sing	_	_	_	_
34	following	follow	VERB	VBG	VerbForm=Ger	_	_	_	_
35	interferon	interferon	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
36	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
37	gamma	gamma	NOUN	NN	Number=Sing	_	_	_	_
38	treatment	treatment	NOUN	NN	Number=Sing	_	_	_	_
39	of	of	ADP	IN	_	_	_	_	_
40	HeLa	HeLa	PROPN	NNP	Number=Sing	_	_	_	_
41	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
42	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2565
# text = Apart from stat3, another cytoplasmic protein was tyrosine phosphorylated and subsequently translocated to the nucleus in response to IL-2.
1	Apart	apart	ADV	RB	_	_	_	_	_
2	from	from	ADP	IN	_	_	_	_	_
3	stat3	stat3	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
4	,	,	PUNCT	,	_	_	_	_	_
5	another	another	DET	DT	_	_	_	_	_
6	cytoplasmic	cytoplasmic	ADJ	JJ	Degree=Pos	_	_	_	_
7	protein	protein	NOUN	NN	Number=Sing	_	_	_	_
8	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
9	tyrosine	tyrosine	ADV	RB	_	_	_	_	_
10	phosphorylated	phosphorylated	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
11	and	and	CCONJ	CC	_	_	_	_	_
12	subsequently	subsequently	ADV	RB	_	_	_	_	_
13	translocated	translocate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
14	to	to	ADP	IN	_	_	_	_	_
15	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
16	nucleus	nucleus	NOUN	NN	Number=Sing	_	_	_	_
17	in	in	ADP	IN	_	_	_	_	_
18	response	response	NOUN	NN	Number=Sing	_	_	_	_
19	to	to	ADP	IN	_	_	_	_	_
20	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
21	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
22	2	2	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
23	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2566
# text = This protein had an apparent molecular mass of 84 kDa and was not recognized by stat3 or stat1 mAb or antisera.
1	This	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
2	protein	protein	NOUN	NN	Number=Sing	_	_	_	_
3	had	have	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
4	an	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
5	apparent	apparent	ADJ	JJ	Degree=Pos	_	_	_	_
6	molecular	molecular	ADJ	JJ	Degree=Pos	_	_	_	_
7	mass	mass	NOUN	NN	Number=Sing	_	_	_	_
8	of	of	ADP	IN	_	_	_	_	_
9	84	84	NUM	CD	NumType=Card	_	_	_	_
10	kDa	kDa	PROPN	NNP	Number=Sing	_	_	_	_
11	and	and	CCONJ	CC	_	_	_	_	_
12	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
13	not	not	PART	RB	_	_	_	_	_
14	recognized	recognize	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
15	by	by	ADP	IN	_	_	_	_	_
16	stat3	stat3	NUM	CD	NumType=Card	_	_	_	_
17	or	or	CCONJ	CC	_	_	_	_	_
18	stat1	stat1	NUM	CD	NumType=Card	_	_	_	_
19	mAb	mAb	NOUN	NN	Number=Sing	_	_	_	_
20	or	or	CCONJ	CC	_	_	_	_	_
21	antisera	antisera	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
22	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2567
# text = Since IL-2 induced nuclear translocation of the 84 kDa protein and stat3 followed identical kinetics, p84 is a candidate for a new, yet undefined, member of the STAT family.
1	Since	since	ADP	IN	_	_	_	_	_
2	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
3	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
4	2	2	NUM	CD	NumType=Card	_	_	_	_
5	induced	induce	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
6	nuclear	nuclear	ADJ	JJ	Degree=Pos	_	_	_	_
7	translocation	translocation	NOUN	NN	Number=Sing	_	_	_	_
8	of	of	ADP	IN	_	_	_	_	_
9	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
10	84	84	NUM	CD	NumType=Card	_	_	_	_
11	kDa	kDa	NOUN	NN	Number=Sing	_	_	_	_
12	protein	protein	NOUN	NN	Number=Sing	_	_	_	_
13	and	and	CCONJ	CC	_	_	_	_	_
14	stat3	stat3	NOUN	NN	Number=Sing	_	_	_	_
15	followed	follow	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
16	identical	identical	ADJ	JJ	Degree=Pos	_	_	_	_
17	kinetics	kinetic	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
18	,	,	PUNCT	,	_	_	_	_	_
19	p84	p84	NOUN	NN	Number=Sing	_	_	_	_
20	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
21	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
22	candidate	candidate	NOUN	NN	Number=Sing	_	_	_	_
23	for	for	ADP	IN	_	_	_	_	_
24	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
25	new	new	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
26	,	,	PUNCT	,	_	_	_	_	_
27	yet	yet	CCONJ	CC	_	_	_	_	_
28	undefined	undefin	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
29	,	,	PUNCT	,	_	_	_	_	_
30	member	member	NOUN	NN	Number=Sing	_	_	_	_
31	of	of	ADP	IN	_	_	_	_	_
32	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
33	STAT	Stat	ADJ	JJ	Degree=Pos	_	_	_	_
34	family	family	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
35	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2568
# text = Taken together, we report that IL-2 induces tyrosine phosphorylation and subsequent nuclear translocation of stat3 and an as yet undefined 84-kDa protein in antigen-specific human T cell lines.
1	Taken	take	PROPN	NNP	Number=Sing	_	_	_	_
2	together	together	ADV	RB	_	_	_	_	SpaceAfter=No
3	,	,	PUNCT	,	_	_	_	_	_
4	we	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
5	report	report	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
6	that	that	SCONJ	IN	_	_	_	_	_
7	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
8	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
9	2	2	NUM	CD	NumType=Card	_	_	_	_
10	induces	induce	NOUN	NNS	Number=Plur	_	_	_	_
11	tyrosine	tyrosine	NOUN	NN	Number=Sing	_	_	_	_
12	phosphorylation	phosphorylation	NOUN	NN	Number=Sing	_	_	_	_
13	and	and	CCONJ	CC	_	_	_	_	_
14	subsequent	subsequent	ADJ	JJ	Degree=Pos	_	_	_	_
15	nuclear	nuclear	ADJ	JJ	Degree=Pos	_	_	_	_
16	translocation	translocation	NOUN	NN	Number=Sing	_	_	_	_
17	of	of	ADP	IN	_	_	_	_	_
18	stat3	stat3	NOUN	NN	Number=Sing	_	_	_	_
19	and	and	CCONJ	CC	_	_	_	_	_
20	an	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
21	as	as	SCONJ	IN	_	_	_	_	_
22	yet	yet	ADV	RB	_	_	_	_	_
23	undefined	undefin	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
24	84	84	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
25	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
26	kDa	kDa	NOUN	NN	Number=Sing	_	_	_	_
27	protein	protein	NOUN	NN	Number=Sing	_	_	_	_
28	in	in	ADP	IN	_	_	_	_	_
29	antigen	antigen	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
30	-specific	-specific	ADJ	JJ	Degree=Pos	_	_	_	_
31	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
32	T	t	PROPN	NNP	Number=Sing	_	_	_	_
33	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
34	lines	line	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
35	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 2569
# text = Document 003003268 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	003003268	003003268	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 2570
# text = Activation of nuclear factor-kappaB via T cell receptor requires a Raf kinase and Ca2+ influx.
1	Activation	Activation	NOUN	NN	Number=Sing	_	_	_	_
2	of	of	ADP	IN	_	_	_	_	_
3	nuclear	nuclear	ADJ	JJ	Degree=Pos	_	_	_	_
4	factor	factor	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
5	-kappaB	-kappab	NOUN	NN	Number=Sing	_	_	_	_
6	via	via	ADP	IN	_	_	_	_	_
7	T	t	PROPN	NNP	Number=Sing	_	_	_	_
8	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
9	receptor	receptor	NOUN	NN	Number=Sing	_	_	_	_
10	requires	require	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
11	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
12	Raf	Raf	PROPN	NNP	Number=Sing	_	_	_	_
13	kinase	kinase	NOUN	NN	Number=Sing	_	_	_	_
14	and	and	CCONJ	CC	_	_	_	_	_
15	Ca2	Ca2	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
16	+	+	SYM	SYM	_	_	_	_	_
17	influx	influx	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
18	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2571
# text = Functional synergy between Raf and calcineurin.
1	Functional	functional	ADJ	JJ	Degree=Pos	_	_	_	_
2	synergy	synergy	NOUN	NN	Number=Sing	_	_	_	_
3	between	between	ADP	IN	_	_	_	_	_
4	Raf	Raf	PROPN	NNP	Number=Sing	_	_	_	_
5	and	and	CCONJ	CC	_	_	_	_	_
6	calcineurin	calcineurin	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
7	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 2572
# text = Signals transduced via the TCR activate the transcription factor nuclear factor-kappaB (NF-kappaB), which, in turn, is critical to the transcriptional induction of many genes important for the proliferation and expression of a differentiated phenotype.
1	Signals	signal	NOUN	NNS	Number=Plur	_	_	_	_
2	transduced	transduce	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
3	via	via	ADP	IN	_	_	_	_	_
4	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
5	TCR	TCR	PROPN	NNP	Number=Sing	_	_	_	_
6	activate	activate	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
7	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
8	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
9	factor	factor	NOUN	NN	Number=Sing	_	_	_	_
10	nuclear	nuclear	ADJ	JJ	Degree=Pos	_	_	_	_
11	factor	factor	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
12	-kappaB	-kappaB	PROPN	NNP	Number=Sing	_	_	_	_
13	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
14	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
15	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
16	kappaB	kappaB	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
17	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
18	,	,	PUNCT	,	_	_	_	_	_
19	which	which	PRON	WDT	PronType=Rel	_	_	_	SpaceAfter=No
20	,	,	PUNCT	,	_	_	_	_	_
21	in	in	ADP	IN	_	_	_	_	_
22	turn	turn	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
23	,	,	PUNCT	,	_	_	_	_	_
24	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
25	critical	critical	ADJ	JJ	Degree=Pos	_	_	_	_
26	to	to	ADP	IN	_	_	_	_	_
27	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
28	transcriptional	transcriptional	ADJ	JJ	Degree=Pos	_	_	_	_
29	induction	induction	NOUN	NN	Number=Sing	_	_	_	_
30	of	of	ADP	IN	_	_	_	_	_
31	many	many	ADJ	JJ	Degree=Pos	_	_	_	_
32	genes	gene	NOUN	NNS	Number=Plur	_	_	_	_
33	important	important	ADJ	JJ	Degree=Pos	_	_	_	_
34	for	for	ADP	IN	_	_	_	_	_
35	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
36	proliferation	proliferation	NOUN	NN	Number=Sing	_	_	_	_
37	and	and	CCONJ	CC	_	_	_	_	_
38	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
39	of	of	ADP	IN	_	_	_	_	_
40	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
41	differentiated	differentiate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
42	phenotype	phenotype	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
43	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2573
# text = Treatment of T cells with the protein kinase C activator PMA in combination with Ca2+ ionophores mimics this process, and the two agents are often substituted for TCR stimulation, bypassing the TCR.
1	Treatment	treatment	NOUN	NN	Number=Sing	_	_	_	_
2	of	of	ADP	IN	_	_	_	_	_
3	T	t	PROPN	NNP	Number=Sing	_	_	_	_
4	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
5	with	with	ADP	IN	_	_	_	_	_
6	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
7	protein	protein	NOUN	NN	Number=Sing	_	_	_	_
8	kinase	kinase	NOUN	NN	Number=Sing	_	_	_	_
9	C	C	PROPN	NNP	Number=Sing	_	_	_	_
10	activator	activator	PROPN	NNP	Number=Sing	_	_	_	_
11	PMA	PMA	PROPN	NNP	Number=Sing	_	_	_	_
12	in	in	ADP	IN	_	_	_	_	_
13	combination	combination	NOUN	NN	Number=Sing	_	_	_	_
14	with	with	ADP	IN	_	_	_	_	_
15	Ca2	Ca2	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
16	+	+	SYM	SYM	_	_	_	_	_
17	ionophores	ionophore	NOUN	NNS	Number=Plur	_	_	_	_
18	mimics	mimics	NOUN	NNS	Number=Plur	_	_	_	_
19	this	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
20	process	process	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
21	,	,	PUNCT	,	_	_	_	_	_
22	and	and	CCONJ	CC	_	_	_	_	_
23	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
24	two	two	NUM	CD	NumType=Card	_	_	_	_
25	agents	agent	NOUN	NNS	Number=Plur	_	_	_	_
26	are	be	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
27	often	often	ADV	RB	_	_	_	_	_
28	substituted	substitute	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
29	for	for	ADP	IN	_	_	_	_	_
30	TCR	Tcr	ADJ	JJR	Degree=Cmp	_	_	_	_
31	stimulation	stimulation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
32	,	,	PUNCT	,	_	_	_	_	_
33	bypassing	bypasse	VERB	VBG	VerbForm=Ger	_	_	_	_
34	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
35	TCR	Tcr	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
36	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2574
# text = Here we identify intracellular signaling components involved in activation of NF-kappaB following TCR stimulation.
1	Here	here	ADV	RB	PronType=Dem	_	_	_	_
2	we	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
3	identify	identify	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
4	intracellular	intracelular	ADJ	JJ	Degree=Pos	_	_	_	_
5	signaling	signal	NOUN	NN	Number=Sing	_	_	_	_
6	components	component	NOUN	NNS	Number=Plur	_	_	_	_
7	involved	involved	ADJ	JJ	Degree=Pos	_	_	_	_
8	in	in	ADP	IN	_	_	_	_	_
9	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
10	of	of	ADP	IN	_	_	_	_	_
11	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
12	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
13	kappaB	kappaB	PROPN	NNP	Number=Sing	_	_	_	_
14	following	follow	VERB	VBG	VerbForm=Ger	_	_	_	_
15	TCR	Tcr	ADP	IN	_	_	_	_	_
16	stimulation	stimulation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
17	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2575
# text = TCR signaling was triggered by treating Jurkat T cells with PHA or anti-CD3 Abs, and NF-kappaB activation was monitored by electrophoretic mobility shift assays and/or by kappaB-dependent reporter assays.
1	TCR	Tcr	NOUN	NN	Number=Sing	_	_	_	_
2	signaling	signaling	NOUN	NN	Number=Sing	_	_	_	_
3	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
4	triggered	trigger	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
5	by	by	SCONJ	IN	_	_	_	_	_
6	treating	treat	VERB	VBG	VerbForm=Ger	_	_	_	_
7	Jurkat	Jurkat	PROPN	NNP	Number=Sing	_	_	_	_
8	T	T	PROPN	NNP	Number=Sing	_	_	_	_
9	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
10	with	with	ADP	IN	_	_	_	_	_
11	PHA	PHa	NOUN	NN	Number=Sing	_	_	_	_
12	or	or	CCONJ	CC	_	_	_	_	_
13	anti-CD3	anti-CD3	NOUN	NN	Number=Sing	_	_	_	_
14	Abs	Ab	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
15	,	,	PUNCT	,	_	_	_	_	_
16	and	and	CCONJ	CC	_	_	_	_	_
17	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
18	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
19	kappaB	kappaB	PROPN	NNP	Number=Sing	_	_	_	_
20	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
21	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
22	monitored	monitor	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
23	by	by	ADP	IN	_	_	_	_	_
24	electrophoretic	electrophoretic	ADJ	JJ	Degree=Pos	_	_	_	_
25	mobility	mobility	NOUN	NN	Number=Sing	_	_	_	_
26	shift	shift	NOUN	NN	Number=Sing	_	_	_	_
27	assays	assays	NOUN	NNS	Number=Plur	_	_	_	_
28	and	and	CCONJ	CC	_	_	_	_	SpaceAfter=No
29	/	/	PUNCT	,	_	_	_	_	SpaceAfter=No
30	or	or	CCONJ	CC	_	_	_	_	_
31	by	by	ADP	IN	_	_	_	_	_
32	kappaB	kappaB	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
33	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
34	dependent	dependent	ADJ	JJ	Degree=Pos	_	_	_	_
35	reporter	reporter	NOUN	NN	Number=Sing	_	_	_	_
36	assays	assay	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
37	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2576
# text = Contrary to the idea that protein kinase C is involved in TCR-mediated activation of NF-kappaB, high doses of staurosporine did not interfere with activation of NF-kappaB by PHA, while the same dose of staurosporine completely blocked activation by PMA.
1	Contrary	contrary	ADJ	JJ	Degree=Pos	_	_	_	_
2	to	to	ADP	IN	_	_	_	_	_
3	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
4	idea	idea	NOUN	NN	Number=Sing	_	_	_	_
5	that	that	PRON	WDT	PronType=Rel	_	_	_	_
6	protein	protein	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
7	kinase	kinase	NOUN	NN	Number=Sing	_	_	_	_
8	C	c	NOUN	NN	Number=Sing	_	_	_	_
9	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
10	involved	involved	ADJ	JJ	Degree=Pos	_	_	_	_
11	in	in	ADP	IN	_	_	_	_	_
12	TCR	TCR	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
13	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
14	mediated	mediate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
15	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
16	of	of	ADP	IN	_	_	_	_	_
17	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
18	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
19	kappaB	kappaB	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
20	,	,	PUNCT	,	_	_	_	_	_
21	high	high	ADJ	JJ	Degree=Pos	_	_	_	_
22	doses	dos	NOUN	NNS	Number=Plur	_	_	_	_
23	of	of	ADP	IN	_	_	_	_	_
24	staurosporine	staurosporine	NOUN	NN	Number=Sing	_	_	_	_
25	did	do	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
26	not	not	PART	RB	_	_	_	_	_
27	interfere	interfere	VERB	VB	VerbForm=Inf	_	_	_	_
28	with	with	ADP	IN	_	_	_	_	_
29	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
30	of	of	ADP	IN	_	_	_	_	_
31	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
32	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
33	kappaB	kappaB	PROPN	NNP	Number=Sing	_	_	_	_
34	by	by	ADP	IN	_	_	_	_	_
35	PHA	PHA	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
36	,	,	PUNCT	,	_	_	_	_	_
37	while	while	SCONJ	IN	_	_	_	_	_
38	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
39	same	same	ADJ	JJ	Degree=Pos	_	_	_	_
40	dose	dose	NOUN	NN	Number=Sing	_	_	_	_
41	of	of	ADP	IN	_	_	_	_	_
42	staurosporine	staurosporine	NOUN	NN	Number=Sing	_	_	_	_
43	completely	completely	ADV	RB	_	_	_	_	_
44	blocked	block	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
45	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
46	by	by	ADP	IN	_	_	_	_	_
47	PMA	PMA	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
48	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2577
# text = PHA-induced kappaB-dependent reporter activity was, however, effectively blocked by a dominant negative form of Raf-1, suggesting a critical role for a Raf kinase.
1	PHA	Pha	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
2	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
3	induced	induce	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
4	kappaB	kappaB	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
5	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
6	dependent	dependent	ADJ	JJ	Degree=Pos	_	_	_	_
7	reporter	reporter	NOUN	NN	Number=Sing	_	_	_	_
8	activity	activity	NOUN	NN	Number=Sing	_	_	_	_
9	was	be	VERB	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	SpaceAfter=No
10	,	,	PUNCT	,	_	_	_	_	_
11	however	however	ADV	RB	_	_	_	_	SpaceAfter=No
12	,	,	PUNCT	,	_	_	_	_	_
13	effectively	effectively	ADV	RB	_	_	_	_	_
14	blocked	block	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
15	by	by	ADP	IN	_	_	_	_	_
16	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
17	dominant	dominant	ADJ	JJ	Degree=Pos	_	_	_	_
18	negative	negative	ADJ	JJ	Degree=Pos	_	_	_	_
19	form	form	NOUN	NN	Number=Sing	_	_	_	_
20	of	of	ADP	IN	_	_	_	_	_
21	Raf	Raf	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
22	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
23	1	1	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
24	,	,	PUNCT	,	_	_	_	_	_
25	suggesting	suggest	VERB	VBG	VerbForm=Ger	_	_	_	_
26	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
27	critical	critical	ADJ	JJ	Degree=Pos	_	_	_	_
28	role	role	NOUN	NN	Number=Sing	_	_	_	_
29	for	for	ADP	IN	_	_	_	_	_
30	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
31	Raf	Raf	PROPN	NNP	Number=Sing	_	_	_	_
32	kinase	kinase	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
33	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2578
# text = The TCR-mediated activation of NF-kappaB was also dependent on a Ca2+ influx, because the Ca2+ channel blocker, SK&F 96365, as well as other agents that prevented the Ca2+ influx, inhibited NF-kappaB activation.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	TCR	Tcr	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
3	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
4	mediated	mediate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
5	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
6	of	of	ADP	IN	_	_	_	_	_
7	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
8	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
9	kappaB	kappaB	PROPN	NNP	Number=Sing	_	_	_	_
10	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
11	also	also	ADV	RB	_	_	_	_	_
12	dependent	dependent	ADJ	JJ	Degree=Pos	_	_	_	_
13	on	on	ADP	IN	_	_	_	_	_
14	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
15	Ca2	ca2	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
16	+	+	SYM	SYM	_	_	_	_	_
17	influx	influx	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
18	,	,	PUNCT	,	_	_	_	_	_
19	because	because	SCONJ	IN	_	_	_	_	_
20	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
21	Ca2	ca2	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
22	+	+	SYM	SYM	_	_	_	_	_
23	channel	channel	NOUN	NN	Number=Sing	_	_	_	_
24	blocker	blocker	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
25	,	,	PUNCT	,	_	_	_	_	_
26	SK&F	SK&F	PROPN	NNP	Number=Sing	_	_	_	_
27	96365	96365	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
28	,	,	PUNCT	,	_	_	_	_	_
29	as	as	ADV	RB	_	_	_	_	_
30	well	well	ADV	RB	Degree=Pos	_	_	_	_
31	as	as	ADP	IN	_	_	_	_	_
32	other	other	ADJ	JJ	Degree=Pos	_	_	_	_
33	agents	agent	NOUN	NNS	Number=Plur	_	_	_	_
34	that	that	PRON	WDT	PronType=Rel	_	_	_	_
35	prevented	prevent	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
36	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
37	Ca2	ca2	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
38	+	+	CCONJ	CC	_	_	_	_	_
39	influx	influx	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
40	,	,	PUNCT	,	_	_	_	_	_
41	inhibited	inhibit	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
42	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
43	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
44	kappaB	kappaB	PROPN	NNP	Number=Sing	_	_	_	_
45	activation	activation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
46	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2579
# text = Cotransfection of a constitutively active form of calcineurin largely substituted for the Ca2+ requirement and reversed the blockade by SK&F 96365.
1	Cotransfection	Cotransfection	NOUN	NN	Number=Sing	_	_	_	_
2	of	of	ADP	IN	_	_	_	_	_
3	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
4	constitutively	constitutively	ADV	RB	_	_	_	_	_
5	active	active	ADJ	JJ	Degree=Pos	_	_	_	_
6	form	form	NOUN	NN	Number=Sing	_	_	_	_
7	of	of	ADP	IN	_	_	_	_	_
8	calcineurin	calcineurin	NOUN	NN	Number=Sing	_	_	_	_
9	largely	largely	ADV	RB	_	_	_	_	_
10	substituted	substitute	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
11	for	for	ADP	IN	_	_	_	_	_
12	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
13	Ca2	ca2	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
14	+	+	CCONJ	CC	_	_	_	_	_
15	requirement	requirement	NOUN	NN	Number=Sing	_	_	_	_
16	and	and	CCONJ	CC	_	_	_	_	_
17	reversed	reverse	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
18	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
19	blockade	blockade	NOUN	NN	Number=Sing	_	_	_	_
20	by	by	ADP	IN	_	_	_	_	_
21	SK&F	SK&F	PROPN	NNP	Number=Sing	_	_	_	_
22	96365	96365	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
23	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2580
# text = Consistent with these observations, coexpression of constitutively active forms of Raf-1 and calcineurin synergistically induced kappaB-dependent reporter activity, suggesting a physiologically relevant functional interaction between the kinase and the phosphatase.
1	Consistent	consistent	ADJ	JJ	Degree=Pos	_	_	_	_
2	with	with	ADP	IN	_	_	_	_	_
3	these	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
4	observations	observation	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
5	,	,	PUNCT	,	_	_	_	_	_
6	coexpression	coexpression	NOUN	NN	Number=Sing	_	_	_	_
7	of	of	ADP	IN	_	_	_	_	_
8	constitutively	constitutively	ADV	RB	_	_	_	_	_
9	active	active	ADJ	JJ	Degree=Pos	_	_	_	_
10	forms	form	NOUN	NNS	Number=Plur	_	_	_	_
11	of	of	ADP	IN	_	_	_	_	_
12	Raf	Raf	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
13	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
14	1	1	NUM	CD	NumType=Card	_	_	_	_
15	and	and	CCONJ	CC	_	_	_	_	_
16	calcineurin	calcineurin	VERB	VB	VerbForm=Inf	_	_	_	_
17	synergistically	synergistically	ADV	RB	_	_	_	_	_
18	induced	induce	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
19	kappaB	kappaB	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
20	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
21	dependent	dependent	ADJ	JJ	Degree=Pos	_	_	_	_
22	reporter	reporter	NOUN	NN	Number=Sing	_	_	_	_
23	activity	activity	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
24	,	,	PUNCT	,	_	_	_	_	_
25	suggesting	suggest	VERB	VBG	VerbForm=Ger	_	_	_	_
26	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
27	physiologically	physiologically	ADV	RB	_	_	_	_	_
28	relevant	relevant	ADJ	JJ	Degree=Pos	_	_	_	_
29	functional	functional	ADJ	JJ	Degree=Pos	_	_	_	_
30	interaction	interaction	NOUN	NN	Number=Sing	_	_	_	_
31	between	between	ADP	IN	_	_	_	_	_
32	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
33	kinase	kinase	NOUN	NN	Number=Sing	_	_	_	_
34	and	and	CCONJ	CC	_	_	_	_	_
35	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
36	phosphatase	phosphatase	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
37	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 2581
# text = Document 003003270 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	003003270	003003270	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 2582
# text = Increased proliferation, cytotoxicity, and gene expression after stimulation of human peripheral blood T lymphocytes through a surface ganglioside (GD3) [published erratum appears in J Immunol 1994 Jul 15;153(2):910] Previous studies have suggested that gangliosides have an important role in cell signaling and recognition.
1	Increased	increase	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
2	proliferation	proliferation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
3	,	,	PUNCT	,	_	_	_	_	_
4	cytotoxicity	cytotoxicity	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
5	,	,	PUNCT	,	_	_	_	_	_
6	and	and	CCONJ	CC	_	_	_	_	_
7	gene	gene	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
8	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
9	after	after	ADP	IN	_	_	_	_	_
10	stimulation	stimulation	NOUN	NN	Number=Sing	_	_	_	_
11	of	of	ADP	IN	_	_	_	_	_
12	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
13	peripheral	peripheral	ADJ	JJ	Degree=Pos	_	_	_	_
14	blood	blood	NOUN	NN	Number=Sing	_	_	_	_
15	T	T	PROPN	NNP	Number=Sing	_	_	_	_
16	lymphocytes	lymphocyte	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
17	through	through	ADP	IN	_	_	_	_	_
18	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
19	surface	surface	NOUN	NN	Number=Sing	_	_	_	_
20	ganglioside	ganglioside	NOUN	NN	Number=Sing	_	_	_	_
21	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
22	GD3	GD3	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
23	)	)	PUNCT	-RRB-	_	_	_	_	_
24	[	[	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
25	published	publish	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
26	erratum	erratum	NOUN	NN	Number=Sing	_	_	_	_
27	appears	appear	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
28	in	in	ADP	IN	_	_	_	_	_
29	J	j	PROPN	NNP	Number=Sing	_	_	_	_
30	Immunol	Immunol	PROPN	NNP	Number=Sing	_	_	_	_
31	1994	1994	NUM	CD	NumType=Card	_	_	_	_
32	Jul	Jul	PROPN	NNP	Number=Sing	_	_	_	_
33	15;153	15;153	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
34	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
35	2	2	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
36	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
37	:910	:910	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
38	]	]	PUNCT	-RRB-	_	_	_	_	SpacesAfter=\s\n
39	Previous	previous	ADJ	JJ	Degree=Pos	_	_	_	_
40	studies	study	NOUN	NNS	Number=Plur	_	_	_	_
41	have	have	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
42	suggested	suggest	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
43	that	that	SCONJ	IN	_	_	_	_	_
44	gangliosides	ganglioside	NOUN	NNS	Number=Plur	_	_	_	_
45	have	have	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
46	an	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
47	important	important	ADJ	JJ	Degree=Pos	_	_	_	_
48	role	role	NOUN	NN	Number=Sing	_	_	_	_
49	in	in	ADP	IN	_	_	_	_	_
50	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
51	signaling	signaling	NOUN	NN	Number=Sing	_	_	_	_
52	and	and	CCONJ	CC	_	_	_	_	_
53	recognition	recognition	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
54	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2583
# text = However, their specific function in these processes has not been clearly defined.
1	However	however	ADV	RB	_	_	_	_	SpaceAfter=No
2	,	,	PUNCT	,	_	_	_	_	_
3	their	they	PRON	PRP$	Number=Plur|Person=3|Poss=Yes|PronType=Prs	_	_	_	_
4	specific	specific	ADJ	JJ	Degree=Pos	_	_	_	_
5	function	function	NOUN	NN	Number=Sing	_	_	_	_
6	in	in	ADP	IN	_	_	_	_	_
7	these	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
8	processes	processe	NOUN	NNS	Number=Plur	_	_	_	_
9	has	have	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
10	not	not	PART	RB	_	_	_	_	_
11	been	be	AUX	VBN	Tense=Past|VerbForm=Part	_	_	_	_
12	clearly	clearly	ADV	RB	_	_	_	_	_
13	defined	define	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	SpaceAfter=No
14	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2584
# text = A mAb, R24, that reacts specifically with a cell surface ganglioside (GD3) has been demonstrated to stimulate proliferation of T cells derived from human peripheral blood.
1	A	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
2	mAb	mAb	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
3	,	,	PUNCT	,	_	_	_	_	_
4	R24	R24	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
5	,	,	PUNCT	,	_	_	_	_	_
6	that	that	PRON	WDT	PronType=Rel	_	_	_	_
7	reacts	react	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
8	specifically	specifically	ADV	RB	_	_	_	_	_
9	with	with	ADP	IN	_	_	_	_	_
10	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
11	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
12	surface	surface	NOUN	NN	Number=Sing	_	_	_	_
13	ganglioside	ganglioside	NOUN	NN	Number=Sing	_	_	_	_
14	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
15	GD3	GD3	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
16	)	)	PUNCT	-RRB-	_	_	_	_	_
17	has	have	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
18	been	be	AUX	VBN	Tense=Past|VerbForm=Part	_	_	_	_
19	demonstrated	demonstrate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
20	to	to	PART	TO	_	_	_	_	_
21	stimulate	stimulate	VERB	VB	VerbForm=Inf	_	_	_	_
22	proliferation	proliferation	NOUN	NN	Number=Sing	_	_	_	_
23	of	of	ADP	IN	_	_	_	_	_
24	T	t	PROPN	NNP	Number=Sing	_	_	_	_
25	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
26	derived	derive	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
27	from	from	ADP	IN	_	_	_	_	_
28	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
29	peripheral	peripheral	ADJ	JJ	Degree=Pos	_	_	_	_
30	blood	blood	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
31	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2585
# text = In this study, we have investigated the mechanisms by which the R24 mAb affects T cell functions.
1	In	in	ADP	IN	_	_	_	_	_
2	this	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
3	study	study	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
4	,	,	PUNCT	,	_	_	_	_	_
5	we	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
6	have	have	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
7	investigated	investigate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
8	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
9	mechanisms	mechanism	NOUN	NNS	Number=Plur	_	_	_	_
10	by	by	ADP	IN	_	_	_	_	_
11	which	which	PRON	WDT	PronType=Rel	_	_	_	_
12	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
13	R24	R24	PROPN	NNP	Number=Sing	_	_	_	_
14	mAb	mAb	PROPN	NNP	Number=Sing	_	_	_	_
15	affects	affect	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
16	T	t	NUM	CD	NumType=Card	_	_	_	_
17	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
18	functions	function	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
19	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2586
# text = We have observed that the R24 mAb stimulates GD3+ T cell proliferation, cytotoxicity, and surface marker expression of IL-2R alpha-chain, IL-2R beta-chain, HLA-DR, CD11a, and CD11c. Additionally, IFN-gamma activity but not IL-1, IL-2, or IL-4 activity was present in culture supernatants 72 h after R24 stimulation.
1	We	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
2	have	have	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
3	observed	observe	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
4	that	that	SCONJ	IN	_	_	_	_	_
5	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
6	R24	R24	PROPN	NNP	Number=Sing	_	_	_	_
7	mAb	mAb	PROPN	NNP	Number=Sing	_	_	_	_
8	stimulates	stimulate	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
9	GD3	GD3	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
10	+	+	SYM	SYM	_	_	_	_	_
11	T	t	NUM	CD	NumType=Card	_	_	_	_
12	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
13	proliferation	proliferation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
14	,	,	PUNCT	,	_	_	_	_	_
15	cytotoxicity	cytotoxicity	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
16	,	,	PUNCT	,	_	_	_	_	_
17	and	and	CCONJ	CC	_	_	_	_	_
18	surface	surface	NOUN	NN	Number=Sing	_	_	_	_
19	marker	marker	NOUN	NN	Number=Sing	_	_	_	_
20	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
21	of	of	ADP	IN	_	_	_	_	_
22	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
23	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
24	2R	2R	PROPN	NNP	Number=Sing	_	_	_	_
25	alpha-chain	alpha-chain	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
26	,	,	PUNCT	,	_	_	_	_	_
27	IL	IL	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
28	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
29	2R	2R	NOUN	NN	Number=Sing	_	_	_	_
30	beta-	beta-	PUNCT	:	_	_	_	_	SpaceAfter=No
31	chain	chain	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
32	,	,	PUNCT	,	_	_	_	_	_
33	HLA-DR	HLA-DR	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
34	,	,	PUNCT	,	_	_	_	_	_
35	CD11a	CD11a	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
36	,	,	PUNCT	,	_	_	_	_	_
37	and	and	CCONJ	CC	_	_	_	_	_
38	CD	C	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
39	11c	11c	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
40	.	.	PUNCT	.	_	_	_	_	_
41	Additionally	additionally	ADV	RB	_	_	_	_	SpaceAfter=No
42	,	,	PUNCT	,	_	_	_	_	_
43	IFN	IFN	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
44	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
45	gamma	gamma	NOUN	NN	Number=Sing	_	_	_	_
46	activity	activity	NOUN	NN	Number=Sing	_	_	_	_
47	but	but	CCONJ	CC	_	_	_	_	_
48	not	not	PART	RB	_	_	_	_	_
49	IL	Il	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
50	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
51	1	1	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
52	,	,	PUNCT	,	_	_	_	_	_
53	IL	Il	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
54	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
55	2	2	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
56	,	,	PUNCT	,	_	_	_	_	_
57	or	or	CCONJ	CC	_	_	_	_	_
58	IL	Il	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
59	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
60	4	4	NUM	CD	NumType=Card	_	_	_	_
61	activity	activity	NOUN	NN	Number=Sing	_	_	_	_
62	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
63	present	present	ADJ	JJ	Degree=Pos	_	_	_	_
64	in	in	ADP	IN	_	_	_	_	_
65	culture	culture	NOUN	NN	Number=Sing	_	_	_	_
66	supernatants	supernatant	NOUN	NNS	Number=Plur	_	_	_	_
67	72	72	NUM	CD	NumType=Card	_	_	_	_
68	h	h	NOUN	NN	Number=Sing	_	_	_	_
69	after	after	ADP	IN	_	_	_	_	_
70	R24	R24	NUM	CD	NumType=Card	_	_	_	_
71	stimulation	stimulation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
72	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2587
# text = In some donors, increased IL-6 and TNF-alpha activity also was detected after R24 treatment.
1	In	in	ADP	IN	_	_	_	_	_
2	some	some	DET	DT	_	_	_	_	_
3	donors	donor	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	,	,	PUNCT	,	_	_	_	_	_
5	increased	increase	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
6	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
7	-	-	SYM	SYM	_	_	_	_	SpaceAfter=No
8	6	6	NUM	CD	NumType=Card	_	_	_	_
9	and	and	CCONJ	CC	_	_	_	_	_
10	TNF	Tnf	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
11	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
12	alpha	alpha	NOUN	NN	Number=Sing	_	_	_	_
13	activity	activity	NOUN	NN	Number=Sing	_	_	_	_
14	also	also	ADV	RB	_	_	_	_	_
15	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
16	detected	detect	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
17	after	after	ADP	IN	_	_	_	_	_
18	R24	R24	NUM	CD	NumType=Card	_	_	_	_
19	treatment	treatment	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
20	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2588
# text = Furthermore, R24 treatment resulted in translocation of c-rel, but little or no NF kappa B p50 or p65, from the cytoplasm to the nucleus and an increase of NF kappa B binding complexes containing c-rel and p50.
1	Furthermore	furthermore	ADV	RB	_	_	_	_	SpaceAfter=No
2	,	,	PUNCT	,	_	_	_	_	_
3	R24	R24	NUM	CD	NumType=Card	_	_	_	_
4	treatment	treatment	NOUN	NN	Number=Sing	_	_	_	_
5	resulted	result	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
6	in	in	ADP	IN	_	_	_	_	_
7	translocation	translocation	NOUN	NN	Number=Sing	_	_	_	_
8	of	of	ADP	IN	_	_	_	_	_
9	c-	c-	SYM	NFP	_	_	_	_	SpaceAfter=No
10	rel	rel	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
11	,	,	PUNCT	,	_	_	_	_	_
12	but	but	CCONJ	CC	_	_	_	_	_
13	little	little	ADJ	JJ	Degree=Pos	_	_	_	_
14	or	or	CCONJ	CC	_	_	_	_	_
15	no	no	DET	DT	_	_	_	_	_
16	NF	Nf	PROPN	NNP	Number=Sing	_	_	_	_
17	kappa	kappa	PROPN	NNP	Number=Sing	_	_	_	_
18	B	b	PROPN	NNP	Number=Sing	_	_	_	_
19	p50	p50	NUM	CD	NumType=Card	_	_	_	_
20	or	or	CCONJ	CC	_	_	_	_	_
21	p65	p65	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
22	,	,	PUNCT	,	_	_	_	_	_
23	from	from	ADP	IN	_	_	_	_	_
24	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
25	cytoplasm	cytoplasm	NOUN	NN	Number=Sing	_	_	_	_
26	to	to	ADP	IN	_	_	_	_	_
27	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
28	nucleus	nucleus	NOUN	NN	Number=Sing	_	_	_	_
29	and	and	CCONJ	CC	_	_	_	_	_
30	an	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
31	increase	increase	NOUN	NN	Number=Sing	_	_	_	_
32	of	of	ADP	IN	_	_	_	_	_
33	NF	NF	PROPN	NNP	Number=Sing	_	_	_	_
34	kappa	kappa	PROPN	NNP	Number=Sing	_	_	_	_
35	B	b	PROPN	NNP	Number=Sing	_	_	_	_
36	binding	binding	VERB	VBG	VerbForm=Ger	_	_	_	_
37	complexes	complex	NOUN	NNS	Number=Plur	_	_	_	_
38	containing	contain	VERB	VBG	VerbForm=Ger	_	_	_	_
39	c-	c-	SYM	NFP	_	_	_	_	SpaceAfter=No
40	rel	rel	NOUN	NN	Number=Sing	_	_	_	_
41	and	and	CCONJ	CC	_	_	_	_	_
42	p50	p50	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
43	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2589
# text = This treatment also caused increased tyrosine phosphorylation of specific protein substrates.
1	This	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
2	treatment	treatment	NOUN	NN	Number=Sing	_	_	_	_
3	also	also	ADV	RB	_	_	_	_	_
4	caused	cause	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
5	increased	increase	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
6	tyrosine	tyrosine	NOUN	NN	Number=Sing	_	_	_	_
7	phosphorylation	phosphorylation	NOUN	NN	Number=Sing	_	_	_	_
8	of	of	ADP	IN	_	_	_	_	_
9	specific	specific	ADJ	JJ	Degree=Pos	_	_	_	_
10	protein	protein	NOUN	NN	Number=Sing	_	_	_	_
11	substrates	substrate	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	SpaceAfter=No
12	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2590
# text = R24-stimulated increases in proliferation, cytotoxicity, and cell surface protein expression could be blocked by cyclosporin and staurosporin, indicating that cyclophilin/calcineurin and protein kinase C may be involved in the R24 signaling pathway.
1	R24	R24	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
2	-stimulated	-stimulate	ADJ	JJ	Degree=Pos	_	_	_	_
3	increases	increase	NOUN	NNS	Number=Plur	_	_	_	_
4	in	in	ADP	IN	_	_	_	_	_
5	proliferation	proliferation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
6	,	,	PUNCT	,	_	_	_	_	_
7	cytotoxicity	cytotoxicity	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
8	,	,	PUNCT	,	_	_	_	_	_
9	and	and	CCONJ	CC	_	_	_	_	_
10	cell	cell	VERB	VB	Mood=Imp|VerbForm=Fin	_	_	_	_
11	surface	surface	NOUN	NN	Number=Sing	_	_	_	_
12	protein	protein	NOUN	NN	Number=Sing	_	_	_	_
13	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
14	could	could	AUX	MD	VerbForm=Fin	_	_	_	_
15	be	be	AUX	VB	VerbForm=Inf	_	_	_	_
16	blocked	block	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
17	by	by	ADP	IN	_	_	_	_	_
18	cyclosporin	cyclosporin	NOUN	NN	Number=Sing	_	_	_	_
19	and	and	CCONJ	CC	_	_	_	_	_
20	staurosporin	staurosporin	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
21	,	,	PUNCT	,	_	_	_	_	_
22	indicating	indicate	VERB	VBG	VerbForm=Ger	_	_	_	_
23	that	that	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
24	cyclophilin	cyclophilin	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
25	/	/	PUNCT	,	_	_	_	_	SpaceAfter=No
26	calcineurin	calcineurin	NOUN	NN	Number=Sing	_	_	_	_
27	and	and	CCONJ	CC	_	_	_	_	_
28	protein	protein	NOUN	NN	Number=Sing	_	_	_	_
29	kinase	kinase	NOUN	NN	Number=Sing	_	_	_	_
30	C	c	PROPN	NNP	Number=Sing	_	_	_	_
31	may	may	AUX	MD	VerbForm=Fin	_	_	_	_
32	be	be	AUX	VB	VerbForm=Inf	_	_	_	_
33	involved	involved	ADJ	JJ	Degree=Pos	_	_	_	_
34	in	in	ADP	IN	_	_	_	_	_
35	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
36	R24	R24	PROPN	NNP	Number=Sing	_	_	_	_
37	signaling	signaling	NOUN	NN	Number=Sing	_	_	_	_
38	pathway	pathway	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
39	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2591
# text = Additionally, herbimycin A, a tyrosine kinase inhibitor, blocked the R24-stimulated increase in proliferation but not cytotoxicity at concentrations consistent with specificity for tyrosine kinases.
1	Additionally	additionally	ADV	RB	_	_	_	_	SpaceAfter=No
2	,	,	PUNCT	,	_	_	_	_	_
3	herbimycin	herbimycin	ADP	IN	_	_	_	_	_
4	A	a	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
5	,	,	PUNCT	,	_	_	_	_	_
6	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
7	tyrosine	tyrosine	NOUN	NN	Number=Sing	_	_	_	_
8	kinase	kinase	NOUN	NN	Number=Sing	_	_	_	_
9	inhibitor	inhibitor	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
10	,	,	PUNCT	,	_	_	_	_	_
11	blocked	block	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
12	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
13	R24	R24	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
14	-stimulated	-stimulated	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
15	increase	increase	NOUN	NN	Number=Sing	_	_	_	_
16	in	in	ADP	IN	_	_	_	_	_
17	proliferation	proliferation	NOUN	NN	Number=Sing	_	_	_	_
18	but	but	CCONJ	CC	_	_	_	_	_
19	not	not	PART	RB	_	_	_	_	_
20	cytotoxicity	cytotoxicity	NOUN	NN	Number=Sing	_	_	_	_
21	at	at	ADP	IN	_	_	_	_	_
22	concentrations	concentration	NOUN	NNS	Number=Plur	_	_	_	_
23	consistent	consistent	ADJ	JJ	Degree=Pos	_	_	_	_
24	with	with	ADP	IN	_	_	_	_	_
25	specificity	specificity	NOUN	NN	Number=Sing	_	_	_	_
26	for	for	ADP	IN	_	_	_	_	_
27	tyrosine	tyrosine	NOUN	NN	Number=Sing	_	_	_	_
28	kinases	kinase	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
29	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2592
# text = These results suggest that multiple biochemical pathways are involved in the activation of human T cells by R24.
1	These	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
2	results	result	NOUN	NNS	Number=Plur	_	_	_	_
3	suggest	suggest	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
4	that	that	SCONJ	IN	_	_	_	_	_
5	multiple	multiple	ADJ	JJ	Degree=Pos	_	_	_	_
6	biochemical	biochemical	ADJ	JJ	Degree=Pos	_	_	_	_
7	pathways	pathway	NOUN	NNS	Number=Plur	_	_	_	_
8	are	be	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
9	involved	involved	ADJ	JJ	Degree=Pos	_	_	_	_
10	in	in	ADP	IN	_	_	_	_	_
11	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
12	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
13	of	of	ADP	IN	_	_	_	_	_
14	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
15	T	t	PROPN	NNP	Number=Sing	_	_	_	_
16	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
17	by	by	ADP	IN	_	_	_	_	_
18	R24	R24	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
19	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 2593
# text = Document 003003272 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	003003272	003003272	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 2594
# text = Nuclear NF-ATp is a hallmark of unstimulated B cells from B-CLL patients.
1	Nuclear	nuclear	PROPN	NNP	Number=Sing	_	_	_	_
2	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
3	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
4	ATp	ATp	PROPN	NNP	Number=Sing	_	_	_	_
5	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
6	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
7	hallmark	hallmark	NOUN	NN	Number=Sing	_	_	_	_
8	of	of	ADP	IN	_	_	_	_	_
9	unstimulated	unstimulated	ADJ	JJ	Degree=Pos	_	_	_	_
10	B	b	ADJ	JJ	Degree=Pos	_	_	_	_
11	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
12	from	from	ADP	IN	_	_	_	_	_
13	B	B	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
14	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
15	CLL	CLL	PROPN	NNP	Number=Sing	_	_	_	_
16	patients	patient	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
17	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 2595
# text = B lymphocytes from the peripheral blood of patients with chronic lymphocytic leukaemia (CLL) were analysed for the nuclear presence and DNA binding of a panel of transcription factors which are involved in the gene control of lymphoid cells.
1	B	b	ADJ	JJ	Degree=Pos	_	_	_	_
2	lymphocytes	lymphocyte	NOUN	NNS	Number=Plur	_	_	_	_
3	from	from	ADP	IN	_	_	_	_	_
4	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
5	peripheral	peripheral	ADJ	JJ	Degree=Pos	_	_	_	_
6	blood	blood	NOUN	NN	Number=Sing	_	_	_	_
7	of	of	ADP	IN	_	_	_	_	_
8	patients	patient	NOUN	NNS	Number=Plur	_	_	_	_
9	with	with	ADP	IN	_	_	_	_	_
10	chronic	chronic	ADJ	JJ	Degree=Pos	_	_	_	_
11	lymphocytic	lymphocytic	ADJ	JJ	Degree=Pos	_	_	_	_
12	leukaemia	leukaemia	NOUN	NN	Number=Sing	_	_	_	_
13	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
14	CLL	Cll	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
15	)	)	PUNCT	-RRB-	_	_	_	_	_
16	were	be	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
17	analysed	analyse	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
18	for	for	ADP	IN	_	_	_	_	_
19	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
20	nuclear	nuclear	ADJ	JJ	Degree=Pos	_	_	_	_
21	presence	presence	NOUN	NN	Number=Sing	_	_	_	_
22	and	and	CCONJ	CC	_	_	_	_	_
23	DNA	dna	NOUN	NN	Number=Sing	_	_	_	_
24	binding	binding	VERB	VBG	VerbForm=Ger	_	_	_	_
25	of	of	ADP	IN	_	_	_	_	_
26	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
27	panel	panel	NOUN	NN	Number=Sing	_	_	_	_
28	of	of	ADP	IN	_	_	_	_	_
29	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
30	factors	factor	NOUN	NNS	Number=Plur	_	_	_	_
31	which	which	PRON	WDT	PronType=Rel	_	_	_	_
32	are	be	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
33	involved	involved	ADJ	JJ	Degree=Pos	_	_	_	_
34	in	in	ADP	IN	_	_	_	_	_
35	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
36	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
37	control	control	NOUN	NN	Number=Sing	_	_	_	_
38	of	of	ADP	IN	_	_	_	_	_
39	lymphoid	lymphoid	ADJ	JJ	Degree=Pos	_	_	_	_
40	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
41	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2596
# text = The following transcription factors were studied: the Octamer factors Oct-1 and Oct-2, members of the AP-1 factor family, NF-AT factors, in particular NF-ATp, and members of the Rel/NF-kB family.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	following	follow	VERB	VBG	VerbForm=Ger	_	_	_	_
3	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
4	factors	factor	NOUN	NNS	Number=Plur	_	_	_	_
5	were	be	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
6	studied	study	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	SpaceAfter=No
7	:	:	PUNCT	:	_	_	_	_	_
8	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
9	Octamer	Octamer	PROPN	NNP	Number=Sing	_	_	_	_
10	factors	factor	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
11	Oct	Oct	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
12	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
13	1	1	NUM	CD	NumType=Card	_	_	_	_
14	and	and	CCONJ	CC	_	_	_	_	_
15	Oct	Oct	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
16	-2	-2	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
17	,	,	PUNCT	,	_	_	_	_	_
18	members	member	NOUN	NNS	Number=Plur	_	_	_	_
19	of	of	ADP	IN	_	_	_	_	_
20	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
21	AP	ap	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
22	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
23	1	1	NUM	CD	NumType=Card	_	_	_	_
24	factor	factor	NOUN	NN	Number=Sing	_	_	_	_
25	family	family	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
26	,	,	PUNCT	,	_	_	_	_	_
27	NF	Nf	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
28	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
29	AT	at	NOUN	NN	Number=Sing	_	_	_	_
30	factors	factor	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
31	,	,	PUNCT	,	_	_	_	_	_
32	in	in	ADP	IN	_	_	_	_	_
33	particular	particular	ADJ	JJ	Degree=Pos	_	_	_	_
34	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
35	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
36	ATp	ATp	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
37	,	,	PUNCT	,	_	_	_	_	_
38	and	and	CCONJ	CC	_	_	_	_	_
39	members	member	NOUN	NNS	Number=Plur	_	_	_	_
40	of	of	ADP	IN	_	_	_	_	_
41	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
42	Rel/	Rel/	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
43	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
44	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
45	kB	kb	PROPN	NNP	Number=Sing	_	_	_	_
46	family	family	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
47	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2597
# text = We show that the constitutive nuclear translocation of NF-ATp, a member of the growing family of NF-AT factors, is a hallmark of nonstimulated B cells from CLL patients that distinguishes B-CLL cells from 'normal' B lymphocytes.
1	We	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
2	show	show	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
3	that	that	SCONJ	IN	_	_	_	_	_
4	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
5	constitutive	constitutive	ADJ	JJ	Degree=Pos	_	_	_	_
6	nuclear	nuclear	ADJ	JJ	Degree=Pos	_	_	_	_
7	translocation	translocation	NOUN	NN	Number=Sing	_	_	_	_
8	of	of	ADP	IN	_	_	_	_	_
9	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
10	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
11	ATp	ATp	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
12	,	,	PUNCT	,	_	_	_	_	_
13	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
14	member	member	NOUN	NN	Number=Sing	_	_	_	_
15	of	of	ADP	IN	_	_	_	_	_
16	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
17	growing	grow	VERB	VBG	VerbForm=Ger	_	_	_	_
18	family	family	NOUN	NN	Number=Sing	_	_	_	_
19	of	of	ADP	IN	_	_	_	_	_
20	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
21	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
22	AT	AT	ADP	IN	_	_	_	_	_
23	factors	factor	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
24	,	,	PUNCT	,	_	_	_	_	_
25	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
26	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
27	hallmark	hallmark	NOUN	NN	Number=Sing	_	_	_	_
28	of	of	ADP	IN	_	_	_	_	_
29	nonstimulated	nonstimulate	ADJ	JJ	Degree=Pos	_	_	_	_
30	B	b	ADJ	JJ	Degree=Pos	_	_	_	_
31	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
32	from	from	ADP	IN	_	_	_	_	_
33	CLL	CLL	DET	DT	_	_	_	_	_
34	patients	patient	NOUN	NNS	Number=Plur	_	_	_	_
35	that	that	PRON	WDT	PronType=Rel	_	_	_	_
36	distinguishes	distinguish	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
37	B	b	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
38	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
39	CLL	Cll	NOUN	NN	Number=Sing	_	_	_	_
40	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
41	from	from	ADP	IN	_	_	_	_	_
42	'	'	PUNCT	``	_	_	_	_	SpaceAfter=No
43	normal	normal	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
44	'	'	PUNCT	''	_	_	_	_	_
45	B	b	NOUN	NN	Number=Sing	_	_	_	_
46	lymphocytes	lymphocyte	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
47	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2598
# text = Constitutive nuclear appearance was also observed for NF-kB2/p52.
1	Constitutive	Constitutive	ADJ	JJ	Degree=Pos	_	_	_	_
2	nuclear	nuclear	ADJ	JJ	Degree=Pos	_	_	_	_
3	appearance	appearance	NOUN	NN	Number=Sing	_	_	_	_
4	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
5	also	also	ADV	RB	_	_	_	_	_
6	observed	observe	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
7	for	for	ADP	IN	_	_	_	_	_
8	NF-	NF-	SYM	NFP	_	_	_	_	SpaceAfter=No
9	kB2/	kB2/	SYM	SYM	_	_	_	_	SpaceAfter=No
10	p52	p52	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
11	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2599
# text = Constitutive binding of further factor proteins to DNA, such as JunD, c-Fos and FosB, was detected in several patients whereas the localisation and DNA binding of other factors such as c-Jun, RelA/p65 and c-Rel was unaltered.
1	Constitutive	Constitutive	ADJ	JJ	Degree=Pos	_	_	_	_
2	binding	binding	NOUN	NN	Number=Sing	_	_	_	_
3	of	of	ADP	IN	_	_	_	_	_
4	further	further	ADJ	JJ	Degree=Pos	_	_	_	_
5	factor	factor	NOUN	NN	Number=Sing	_	_	_	_
6	proteins	protein	NOUN	NNS	Number=Plur	_	_	_	_
7	to	to	ADP	IN	_	_	_	_	_
8	DNA	Dna	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
9	,	,	PUNCT	,	_	_	_	_	_
10	such	such	ADJ	JJ	Degree=Pos	_	_	_	_
11	as	as	ADP	IN	_	_	_	_	_
12	JunD	JunD	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
13	,	,	PUNCT	,	_	_	_	_	_
14	c-	c-	SYM	NFP	_	_	_	_	SpaceAfter=No
15	Fos	Fos	PROPN	NNP	Number=Sing	_	_	_	_
16	and	and	CCONJ	CC	_	_	_	_	_
17	FosB	FosB	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
18	,	,	PUNCT	,	_	_	_	_	_
19	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
20	detected	detect	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
21	in	in	ADP	IN	_	_	_	_	_
22	several	several	ADJ	JJ	Degree=Pos	_	_	_	_
23	patients	patient	NOUN	NNS	Number=Plur	_	_	_	_
24	whereas	whereas	SCONJ	IN	_	_	_	_	_
25	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
26	localisation	localisation	NOUN	NN	Number=Sing	_	_	_	_
27	and	and	CCONJ	CC	_	_	_	_	_
28	DNA	dna	NOUN	NN	Number=Sing	_	_	_	_
29	binding	binding	VERB	VBG	VerbForm=Ger	_	_	_	_
30	of	of	ADP	IN	_	_	_	_	_
31	other	other	ADJ	JJ	Degree=Pos	_	_	_	_
32	factors	factor	NOUN	NNS	Number=Plur	_	_	_	_
33	such	such	ADJ	JJ	Degree=Pos	_	_	_	_
34	as	as	ADP	IN	_	_	_	_	_
35	c	c	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
36	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
37	Jun	Jun	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
38	,	,	PUNCT	,	_	_	_	_	_
39	RelA	RelA	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
40	/	/	PUNCT	,	_	_	_	_	SpaceAfter=No
41	p65	p65	NOUN	NN	Number=Sing	_	_	_	_
42	and	and	CCONJ	CC	_	_	_	_	_
43	c	c	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
44	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
45	Rel	Rel	NOUN	NN	Number=Sing	_	_	_	_
46	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
47	unaltered	unalter	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
48	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2600
# text = It is remarkable that in B-CLL cells the nuclear appearance and DNA binding of specific transcription factors is dramatically affected whereas other members of the same factor family remained unaltered in these leukemic cells.
1	It	it	PRON	PRP	Case=Nom|Gender=Neut|Number=Sing|Person=3|PronType=Prs	_	_	_	_
2	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
3	remarkable	remarkable	ADJ	JJ	Degree=Pos	_	_	_	_
4	that	that	SCONJ	IN	_	_	_	_	_
5	in	in	ADP	IN	_	_	_	_	_
6	B	B	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
7	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
8	CLL	CLL	PROPN	NNP	Number=Sing	_	_	_	_
9	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
10	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
11	nuclear	nuclear	ADJ	JJ	Degree=Pos	_	_	_	_
12	appearance	appearance	NOUN	NN	Number=Sing	_	_	_	_
13	and	and	CCONJ	CC	_	_	_	_	_
14	DNA	dna	NOUN	NN	Number=Sing	_	_	_	_
15	binding	binding	VERB	VBG	VerbForm=Ger	_	_	_	_
16	of	of	ADP	IN	_	_	_	_	_
17	specific	specific	ADJ	JJ	Degree=Pos	_	_	_	_
18	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
19	factors	factor	NOUN	NNS	Number=Plur	_	_	_	_
20	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
21	dramatically	dramatically	ADV	RB	_	_	_	_	_
22	affected	affect	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
23	whereas	wherea	NOUN	NNS	Number=Plur	_	_	_	_
24	other	other	ADJ	JJ	Degree=Pos	_	_	_	_
25	members	member	NOUN	NNS	Number=Plur	_	_	_	_
26	of	of	ADP	IN	_	_	_	_	_
27	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
28	same	same	ADJ	JJ	Degree=Pos	_	_	_	_
29	factor	factor	NOUN	NN	Number=Sing	_	_	_	_
30	family	family	NOUN	NN	Number=Sing	_	_	_	_
31	remained	remain	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
32	unaltered	unaltered	ADJ	JJ	Degree=Pos	_	_	_	_
33	in	in	ADP	IN	_	_	_	_	_
34	these	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
35	leukemic	leukemic	ADJ	JJ	Degree=Pos	_	_	_	_
36	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
37	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2601
# text = It remains to be shown which molecular events lead to the specific 'pre-activation', i.e.
1	It	it	PRON	PRP	Case=Nom|Gender=Neut|Number=Sing|Person=3|PronType=Prs	_	_	_	_
2	remains	remain	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
3	to	to	PART	TO	_	_	_	_	_
4	be	be	AUX	VB	VerbForm=Inf	_	_	_	_
5	shown	show	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
6	which	which	DET	WDT	PronType=Int	_	_	_	_
7	molecular	molecular	ADJ	JJ	Degree=Pos	_	_	_	_
8	events	event	NOUN	NNS	Number=Plur	_	_	_	_
9	lead	lead	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
10	to	to	ADP	IN	_	_	_	_	_
11	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
12	specific	specific	ADJ	JJ	Degree=Pos	_	_	_	_
13	'	'	PUNCT	``	_	_	_	_	SpaceAfter=No
14	pre-activation	pre-activation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
15	'	'	PUNCT	''	_	_	_	_	SpaceAfter=No
16	,	,	PUNCT	,	_	_	_	_	_
17	i.e.	i.e.	X	FW	_	_	_	_	_

# sent_id = 2602
# text = constitutive nuclear translocation and DNA binding, of these members of NF-AT, NF-kB and AP-1 factor families.
1	constitutive	constitutive	ADJ	JJ	Degree=Pos	_	_	_	_
2	nuclear	nuclear	ADJ	JJ	Degree=Pos	_	_	_	_
3	translocation	translocation	NOUN	NN	Number=Sing	_	_	_	_
4	and	and	CCONJ	CC	_	_	_	_	_
5	DNA	dna	NOUN	NN	Number=Sing	_	_	_	_
6	binding	binding	VERB	VBG	VerbForm=Ger	_	_	_	SpaceAfter=No
7	,	,	PUNCT	,	_	_	_	_	_
8	of	of	ADP	IN	_	_	_	_	_
9	these	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
10	members	member	NOUN	NNS	Number=Plur	_	_	_	_
11	of	of	ADP	IN	_	_	_	_	_
12	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
13	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
14	AT	AT	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
15	,	,	PUNCT	,	_	_	_	_	_
16	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
17	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
18	kB	kb	PROPN	NNP	Number=Sing	_	_	_	_
19	and	and	CCONJ	CC	_	_	_	_	_
20	AP	ap	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
21	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
22	1	1	NUM	CD	NumType=Card	_	_	_	_
23	factor	factor	NOUN	NN	Number=Sing	_	_	_	_
24	families	family	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
25	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 2603
# text = Document 003003277 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	003003277	003003277	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 2604
# text = MDS1/EVI1 enhances TGF-beta1 signaling and strengthens its growth-inhibitory effect but the leukemia-associated fusion protein AML1/MDS1/EVI1, product of the t(3;21), abrogates growth-inhibition in response to TGF-beta1.
1	MDS1/EVI1	MDS1/EVI1	NUM	CD	NumType=Card	_	_	_	_
2	enhances	enhance	NOUN	NNS	Number=Plur	_	_	_	_
3	TGF	TGF	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
4	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
5	beta1	beta1	NOUN	NN	Number=Sing	_	_	_	_
6	signaling	signaling	NOUN	NN	Number=Sing	_	_	_	_
7	and	and	CCONJ	CC	_	_	_	_	_
8	strengthens	strengthen	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
9	its	its	PRON	PRP$	Gender=Neut|Number=Sing|Person=3|Poss=Yes|PronType=Prs	_	_	_	_
10	growth	growth	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
11	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
12	inhibitory	inhibitory	NOUN	NN	Number=Sing	_	_	_	_
13	effect	effect	NOUN	NN	Number=Sing	_	_	_	_
14	but	but	CCONJ	CC	_	_	_	_	_
15	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
16	leukemia	leukemia	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
17	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
18	associated	associate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
19	fusion	fusion	NOUN	NN	Number=Sing	_	_	_	_
20	protein	protein	NOUN	NN	Number=Sing	_	_	_	_
21	AML1/MDS1/EVI1	Aml1/mds1/evi1	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
22	,	,	PUNCT	,	_	_	_	_	_
23	product	product	NOUN	NN	Number=Sing	_	_	_	_
24	of	of	ADP	IN	_	_	_	_	_
25	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
26	t	t	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
27	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
28	3;21	3;21	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
29	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
30	,	,	PUNCT	,	_	_	_	_	_
31	abrogates	abrogate	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
32	growth	growth	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
33	-inhibition	-inhibition	NOUN	NN	Number=Sing	_	_	_	_
34	in	in	ADP	IN	_	_	_	_	_
35	response	response	NOUN	NN	Number=Sing	_	_	_	_
36	to	to	ADP	IN	_	_	_	_	_
37	TGF	TGF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
38	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
39	beta1	beta1	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
40	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 2605
# text = MDS1/EVI1, located on chromosome 3 band q26, encodes a zinc-finger DNA-binding transcription activator not detected in normal hematopoietic cells but expressed in several normal tissues.
1	MDS1/EVI1	MDS1/EVI1	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
2	,	,	PUNCT	,	_	_	_	_	_
3	located	locate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
4	on	on	ADP	IN	_	_	_	_	_
5	chromosome	chromosome	NOUN	NN	Number=Sing	_	_	_	_
6	3	3	NUM	CD	NumType=Card	_	_	_	_
7	band	band	NOUN	NN	Number=Sing	_	_	_	_
8	q26	q26	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
9	,	,	PUNCT	,	_	_	_	_	_
10	encodes	encode	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
11	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
12	zinc	zinc	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
13	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
14	finger	finger	NOUN	NN	Number=Sing	_	_	_	_
15	DNA	dna	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
16	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
17	binding	bind	VERB	VBG	VerbForm=Ger	_	_	_	_
18	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
19	activator	activator	NOUN	NN	Number=Sing	_	_	_	_
20	not	not	PART	RB	_	_	_	_	_
21	detected	detect	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
22	in	in	ADP	IN	_	_	_	_	_
23	normal	normal	ADJ	JJ	Degree=Pos	_	_	_	_
24	hematopoietic	hematopoietic	ADJ	JJ	Degree=Pos	_	_	_	_
25	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
26	but	but	CCONJ	CC	_	_	_	_	_
27	expressed	express	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
28	in	in	ADP	IN	_	_	_	_	_
29	several	several	ADJ	JJ	Degree=Pos	_	_	_	_
30	normal	normal	ADJ	JJ	Degree=Pos	_	_	_	_
31	tissues	tissue	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
32	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2606
# text = MDS1/EVI1 is inappropriately activated in myeloid leukemias following chromosomal rearrangements involving band 3q26.
1	MDS1/EVI1	Mds1/evi1	NOUN	NN	Number=Sing	_	_	_	_
2	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
3	inappropriately	inappropriately	ADV	RB	_	_	_	_	_
4	activated	activate	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
5	in	in	ADP	IN	_	_	_	_	_
6	myeloid	myeloid	ADJ	JJ	Degree=Pos	_	_	_	_
7	leukemias	leukemia	NOUN	NNS	Number=Plur	_	_	_	_
8	following	follow	VERB	VBG	VerbForm=Ger	_	_	_	_
9	chromosomal	chromosomal	ADJ	JJ	Degree=Pos	_	_	_	_
10	rearrangements	rearrangement	NOUN	NNS	Number=Plur	_	_	_	_
11	involving	involve	VERB	VBG	VerbForm=Ger	_	_	_	_
12	band	band	NOUN	NN	Number=Sing	_	_	_	_
13	3q	3q	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
14	26	26	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
15	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2607
# text = The rearrangements lead either to gene truncation, and to expression of the transcription repressor EVI1, as seen in the t(3;3)(q21;q26) and inv(3)(q21q26), or to gene fusion, as seen in the t(3;21)(q26;q22) which results in the fusion protein AML1/MDS1/EVI1.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	rearrangements	rearrangement	NOUN	NNS	Number=Plur	_	_	_	_
3	lead	lead	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
4	either	either	ADV	RB	_	_	_	_	_
5	to	to	PART	TO	_	_	_	_	_
6	gene	gene	VERB	VB	VerbForm=Inf	_	_	_	_
7	truncation	truncation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
8	,	,	PUNCT	,	_	_	_	_	_
9	and	and	CCONJ	CC	_	_	_	_	_
10	to	to	ADP	IN	_	_	_	_	_
11	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
12	of	of	ADP	IN	_	_	_	_	_
13	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
14	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
15	repressor	repressor	NOUN	NN	Number=Sing	_	_	_	_
16	EVI1	EVI1	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
17	,	,	PUNCT	,	_	_	_	_	_
18	as	as	SCONJ	IN	_	_	_	_	_
19	seen	see	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
20	in	in	ADP	IN	_	_	_	_	_
21	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
22	t	t	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
23	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
24	3;3)	3;3)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
25	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
26	q21;q26	q21;q26	X	LS	_	_	_	_	SpaceAfter=No
27	)	)	PUNCT	-RRB-	_	_	_	_	_
28	and	and	CCONJ	CC	_	_	_	_	_
29	inv	inv	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
30	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
31	3)	3)	SYM	NFP	_	_	_	_	SpaceAfter=No
32	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
33	q21q26	q21q26	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
34	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
35	,	,	PUNCT	,	_	_	_	_	_
36	or	or	CCONJ	CC	_	_	_	_	_
37	to	to	PART	TO	_	_	_	_	_
38	gene	gene	VERB	VB	VerbForm=Inf	_	_	_	_
39	fusion	fusion	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
40	,	,	PUNCT	,	_	_	_	_	_
41	as	as	SCONJ	IN	_	_	_	_	_
42	seen	see	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
43	in	in	ADP	IN	_	_	_	_	_
44	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
45	t(	t(	SYM	NFP	_	_	_	_	SpaceAfter=No
46	3;21	3;21	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
47	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
48	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
49	q26;q22	q26;q22	X	LS	_	_	_	_	SpaceAfter=No
50	)	)	PUNCT	-RRB-	_	_	_	_	_
51	which	which	DET	WDT	PronType=Int	_	_	_	_
52	results	result	NOUN	NNS	Number=Plur	_	_	_	_
53	in	in	ADP	IN	_	_	_	_	_
54	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
55	fusion	fusion	NOUN	NN	Number=Sing	_	_	_	_
56	protein	protein	NOUN	NN	Number=Sing	_	_	_	_
57	AML1/MDS1/EVI1	AML1/MDS1/EVI1	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
58	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2608
# text = This fusion protein contains the DNA-binding domain of the transcription factor AML1 fused in-frame to the entire MDS1/EVI1 with the exclusion of its first 12 amino acids.
1	This	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
2	fusion	fusion	NOUN	NN	Number=Sing	_	_	_	_
3	protein	protein	NOUN	NN	Number=Sing	_	_	_	_
4	contains	contain	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
5	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
6	DNA	dna	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
7	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
8	binding	bind	VERB	VBG	VerbForm=Ger	_	_	_	_
9	domain	domain	NOUN	NN	Number=Sing	_	_	_	_
10	of	of	ADP	IN	_	_	_	_	_
11	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
12	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
13	factor	factor	NOUN	NN	Number=Sing	_	_	_	_
14	AML1	Aml1	NOUN	NN	Number=Sing	_	_	_	_
15	fused	fuse	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
16	in	in	ADP	IN	_	_	_	_	SpaceAfter=No
17	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
18	frame	frame	NOUN	NN	Number=Sing	_	_	_	_
19	to	to	ADP	IN	_	_	_	_	_
20	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
21	entire	entire	ADJ	JJ	Degree=Pos	_	_	_	_
22	MDS1/EVI1	Mds1/evi1	NOUN	NN	Number=Sing	_	_	_	_
23	with	with	ADP	IN	_	_	_	_	_
24	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
25	exclusion	exclusion	NOUN	NN	Number=Sing	_	_	_	_
26	of	of	ADP	IN	_	_	_	_	_
27	its	its	PRON	PRP$	Gender=Neut|Number=Sing|Person=3|Poss=Yes|PronType=Prs	_	_	_	_
28	first	first	ADJ	JJ	Degree=Pos|NumType=Ord	_	_	_	_
29	12	12	NUM	CD	NumType=Card	_	_	_	_
30	amino	amino	NOUN	NN	Number=Sing	_	_	_	_
31	acids	acid	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
32	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2609
# text = In this report, we have analyzed the response of the hematopoietic precursor cell line 32Dcl3, expressing either the normal protein MDS1/EVI1 or the fusion protein AML1/MDS1/EVI1, to factors that control cell differentiation or cell replication.
1	In	in	ADP	IN	_	_	_	_	_
2	this	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
3	report	report	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
4	,	,	PUNCT	,	_	_	_	_	_
5	we	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
6	have	have	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
7	analyzed	analyze	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
8	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
9	response	response	NOUN	NN	Number=Sing	_	_	_	_
10	of	of	ADP	IN	_	_	_	_	_
11	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
12	hematopoietic	hematopoietic	ADJ	JJ	Degree=Pos	_	_	_	_
13	precursor	precursor	NOUN	NN	Number=Sing	_	_	_	_
14	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
15	line	line	NOUN	NN	Number=Sing	_	_	_	_
16	32	32	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
17	Dcl3	Dcl3	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
18	,	,	PUNCT	,	_	_	_	_	_
19	expressing	expresse	VERB	VBG	VerbForm=Ger	_	_	_	_
20	either	either	CCONJ	CC	_	_	_	_	_
21	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
22	normal	normal	ADJ	JJ	Degree=Pos	_	_	_	_
23	protein	protein	NOUN	NN	Number=Sing	_	_	_	_
24	MDS1/EVI1	Mds1/evi1	NOUN	NN	Number=Sing	_	_	_	_
25	or	or	CCONJ	CC	_	_	_	_	_
26	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
27	fusion	fusion	NOUN	NN	Number=Sing	_	_	_	_
28	protein	protein	NOUN	NN	Number=Sing	_	_	_	_
29	AML1/MDS1/EVI1	AML1/MDS1/EVI1	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
30	,	,	PUNCT	,	_	_	_	_	_
31	to	to	ADP	IN	_	_	_	_	_
32	factors	factor	NOUN	NNS	Number=Plur	_	_	_	_
33	that	that	PRON	WDT	PronType=Rel	_	_	_	_
34	control	control	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
35	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
36	differentiation	differentiation	NOUN	NN	Number=Sing	_	_	_	_
37	or	or	CCONJ	CC	_	_	_	_	_
38	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
39	replication	replication	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
40	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2610
# text = The 32Dcl3 cells are IL-3-dependent for growth and they differentiate into granulocytes when exposed to G-CSF.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	32	32	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
3	Dcl3	Dcl3	NOUN	NN	Number=Sing	_	_	_	_
4	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
5	are	be	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
6	IL	Il	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
7	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
8	3	3	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
9	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
10	dependent	dependent	ADJ	JJ	Degree=Pos	_	_	_	_
11	for	for	ADP	IN	_	_	_	_	_
12	growth	growth	NOUN	NN	Number=Sing	_	_	_	_
13	and	and	CCONJ	CC	_	_	_	_	_
14	they	they	PRON	PRP	Case=Nom|Number=Plur|Person=3|PronType=Prs	_	_	_	_
15	differentiate	differentiate	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
16	into	into	ADP	IN	_	_	_	_	_
17	granulocytes	granulocyte	NOUN	NNS	Number=Plur	_	_	_	_
18	when	when	ADV	WRB	PronType=Int	_	_	_	_
19	exposed	expose	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
20	to	to	ADP	IN	_	_	_	_	_
21	G-	G-	PUNCT	NFP	_	_	_	_	SpaceAfter=No
22	CSF	CSF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
23	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2611
# text = They are growth-inhibited by TGF-beta1.
1	They	they	PRON	PRP	Case=Nom|Number=Plur|Person=3|PronType=Prs	_	_	_	_
2	are	be	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
3	growth	growth	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
4	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
5	inhibited	inhibit	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
6	by	by	ADP	IN	_	_	_	_	_
7	TGF	TGF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
8	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
9	beta1	beta1	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
10	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2612
# text = We show that whereas the expression of MDS1/EVI1 has no effect on granulocytic differentiation induced by G-CSF, expression of AML1/MDS1/EVI1 blocks differentiation resulting in cell death.
1	We	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
2	show	show	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
3	that	that	SCONJ	IN	_	_	_	_	_
4	whereas	whereas	SCONJ	IN	_	_	_	_	_
5	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
6	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
7	of	of	ADP	IN	_	_	_	_	_
8	MDS	MDS	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
9	1	1	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
10	/	/	PUNCT	,	_	_	_	_	SpaceAfter=No
11	EVI1	Evi1	PROPN	NNP	Number=Sing	_	_	_	_
12	has	have	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
13	no	no	DET	DT	_	_	_	_	_
14	effect	effect	NOUN	NN	Number=Sing	_	_	_	_
15	on	on	ADP	IN	_	_	_	_	_
16	granulocytic	granulocytic	ADJ	JJ	Degree=Pos	_	_	_	_
17	differentiation	differentiation	NOUN	NN	Number=Sing	_	_	_	_
18	induced	induce	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
19	by	by	ADP	IN	_	_	_	_	_
20	G-	G-	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
21	CSF	CSF	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
22	,	,	PUNCT	,	_	_	_	_	_
23	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
24	of	of	ADP	IN	_	_	_	_	_
25	AML1/MDS1/EVI1	AML1/MDS1/EVI1	NUM	CD	NumType=Card	_	_	_	_
26	blocks	block	NOUN	NNS	Number=Plur	_	_	_	_
27	differentiation	differentiation	NOUN	NN	Number=Sing	_	_	_	_
28	resulting	result	VERB	VBG	VerbForm=Ger	_	_	_	_
29	in	in	ADP	IN	_	_	_	_	_
30	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
31	death	death	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
32	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2613
# text = This effect is similar to that previously described by others for 32Dcl3 cells that express transgenic Evil.
1	This	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
2	effect	effect	NOUN	NN	Number=Sing	_	_	_	_
3	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
4	similar	similar	ADJ	JJ	Degree=Pos	_	_	_	_
5	to	to	ADP	IN	_	_	_	_	_
6	that	that	PRON	DT	Number=Sing|PronType=Dem	_	_	_	_
7	previously	previously	ADV	RB	_	_	_	_	_
8	described	describe	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
9	by	by	ADP	IN	_	_	_	_	_
10	others	other	NOUN	NNS	Number=Plur	_	_	_	_
11	for	for	ADP	IN	_	_	_	_	_
12	32	32	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
13	Dcl3	Dcl3	NUM	CD	NumType=Card	_	_	_	_
14	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
15	that	that	PRON	WDT	PronType=Rel	_	_	_	_
16	express	express	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
17	transgenic	transgenic	ADJ	JJ	Degree=Pos	_	_	_	_
18	Evil	evil	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
19	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2614
# text = Furthermore, we show that whereas the expression of the fusion protein AML1/MDS1/EVI1 completely abrogates the growth-inhibitory effect of TGF-beta1 and allows 32Dcl3 cells to proliferate, expression of the normal protein MDS1/EVI1 has the opposite effect, and it strengthens the response of cells to the growth-inhibitory effect of TGF-beta1.
1	Furthermore	furthermore	ADV	RB	_	_	_	_	SpaceAfter=No
2	,	,	PUNCT	,	_	_	_	_	_
3	we	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
4	show	show	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
5	that	that	SCONJ	IN	_	_	_	_	_
6	whereas	whereas	SCONJ	IN	_	_	_	_	_
7	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
8	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
9	of	of	ADP	IN	_	_	_	_	_
10	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
11	fusion	fusion	NOUN	NN	Number=Sing	_	_	_	_
12	protein	protein	ADV	WRB	PronType=Rel	_	_	_	_
13	AML1/MDS1/EVI1	AML1/MDS1/EVI1	PROPN	NNP	Number=Sing	_	_	_	_
14	completely	completely	ADV	RB	_	_	_	_	_
15	abrogates	abrogate	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
16	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
17	growth	growth	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
18	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
19	inhibitory	inhibitory	NOUN	NN	Number=Sing	_	_	_	_
20	effect	effect	NOUN	NN	Number=Sing	_	_	_	_
21	of	of	ADP	IN	_	_	_	_	_
22	TGF	TGF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
23	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
24	beta1	beta1	NUM	CD	NumType=Card	_	_	_	_
25	and	and	CCONJ	CC	_	_	_	_	_
26	allows	allow	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
27	32	32	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
28	Dcl3	Dcl3	NUM	CD	NumType=Card	_	_	_	_
29	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
30	to	to	PART	TO	_	_	_	_	_
31	proliferate	proliferate	VERB	VB	VerbForm=Inf	_	_	_	SpaceAfter=No
32	,	,	PUNCT	,	_	_	_	_	_
33	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
34	of	of	ADP	IN	_	_	_	_	_
35	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
36	normal	normal	ADJ	JJ	Degree=Pos	_	_	_	_
37	protein	protein	NOUN	NN	Number=Sing	_	_	_	_
38	MDS	mds	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
39	1	1	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
40	/	/	PUNCT	,	_	_	_	_	SpaceAfter=No
41	EVI1	EVI1	PROPN	NNP	Number=Sing	_	_	_	_
42	has	have	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
43	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
44	opposite	opposite	ADJ	JJ	Degree=Pos	_	_	_	_
45	effect	effect	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
46	,	,	PUNCT	,	_	_	_	_	_
47	and	and	CCONJ	CC	_	_	_	_	_
48	it	it	PRON	PRP	Case=Nom|Gender=Neut|Number=Sing|Person=3|PronType=Prs	_	_	_	_
49	strengthens	strengthen	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
50	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
51	response	response	NOUN	NN	Number=Sing	_	_	_	_
52	of	of	ADP	IN	_	_	_	_	_
53	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
54	to	to	ADP	IN	_	_	_	_	_
55	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
56	growth	growth	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
57	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
58	inhibitory	inhibitory	NOUN	NN	Number=Sing	_	_	_	_
59	effect	effect	NOUN	NN	Number=Sing	_	_	_	_
60	of	of	ADP	IN	_	_	_	_	_
61	TGF	TGF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
62	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
63	beta1	beta1	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
64	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2615
# text = By using the yeast two-hybrid system, we also show that EVI1 (contained in its entirety in MDS1/EVI1 and AML1/MDS1/EVI1) physically interacts with SMAD3, which is an intracellular mediator of TGF-beta1 signaling.
1	By	by	SCONJ	IN	_	_	_	_	_
2	using	use	VERB	VBG	VerbForm=Ger	_	_	_	_
3	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
4	yeast	yeast	ADJ	JJS	Degree=Sup	_	_	_	_
5	two	two	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
6	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
7	hybrid	hybrid	NOUN	NN	Number=Sing	_	_	_	_
8	system	system	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
9	,	,	PUNCT	,	_	_	_	_	_
10	we	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
11	also	also	ADV	RB	_	_	_	_	_
12	show	show	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
13	that	that	SCONJ	IN	_	_	_	_	_
14	EVI1	EVI1	PROPN	NNP	Number=Sing	_	_	_	_
15	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
16	contained	contain	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
17	in	in	ADP	IN	_	_	_	_	_
18	its	its	PRON	PRP$	Gender=Neut|Number=Sing|Person=3|Poss=Yes|PronType=Prs	_	_	_	_
19	entirety	entirety	NOUN	NN	Number=Sing	_	_	_	_
20	in	in	ADP	IN	_	_	_	_	_
21	MDS1/EVI1	Mds1/evi1	PROPN	NNP	Number=Sing	_	_	_	_
22	and	and	CCONJ	CC	_	_	_	_	_
23	AML1/MDS1/EVI1	Aml1/mds1/evi1	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
24	)	)	PUNCT	-RRB-	_	_	_	_	_
25	physically	physically	ADV	RB	_	_	_	_	_
26	interacts	interact	NOUN	NNS	Number=Plur	_	_	_	_
27	with	with	ADP	IN	_	_	_	_	_
28	SMAD3	SMAD3	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
29	,	,	PUNCT	,	_	_	_	_	_
30	which	which	PRON	WDT	PronType=Rel	_	_	_	_
31	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
32	an	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
33	intracellular	intracellular	ADJ	JJ	Degree=Pos	_	_	_	_
34	mediator	mediator	NOUN	NN	Number=Sing	_	_	_	_
35	of	of	ADP	IN	_	_	_	_	_
36	TGF	TGF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
37	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
38	beta1	beta1	NUM	CD	NumType=Card	_	_	_	_
39	signaling	signaling	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
40	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2616
# text = Finally, we have correlated the response of the cells to G-CSF or TGF-beta1 with the ability of the normal and fusion proteins to activate or repress promoters which they can directly regulate by binding to the promoter site.
1	Finally	finally	ADV	RB	_	_	_	_	SpaceAfter=No
2	,	,	PUNCT	,	_	_	_	_	_
3	we	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
4	have	have	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
5	correlated	correlate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
6	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
7	response	response	NOUN	NN	Number=Sing	_	_	_	_
8	of	of	ADP	IN	_	_	_	_	_
9	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
10	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
11	to	to	ADP	IN	_	_	_	_	_
12	G-	G-	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
13	CSF	CSF	NOUN	NN	Number=Sing	_	_	_	_
14	or	or	CCONJ	CC	_	_	_	_	_
15	TGF	TGF	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
16	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
17	beta1	beta1	NOUN	NN	Number=Sing	_	_	_	_
18	with	with	ADP	IN	_	_	_	_	_
19	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
20	ability	ability	NOUN	NN	Number=Sing	_	_	_	_
21	of	of	ADP	IN	_	_	_	_	_
22	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
23	normal	normal	ADJ	JJ	Degree=Pos	_	_	_	_
24	and	and	CCONJ	CC	_	_	_	_	_
25	fusion	fusion	NOUN	NN	Number=Sing	_	_	_	_
26	proteins	protein	NOUN	NNS	Number=Plur	_	_	_	_
27	to	to	PART	TO	_	_	_	_	_
28	activate	activate	VERB	VB	VerbForm=Inf	_	_	_	_
29	or	or	CCONJ	CC	_	_	_	_	_
30	repress	repress	VERB	VB	VerbForm=Inf	_	_	_	_
31	promoters	promoter	NOUN	NNS	Number=Plur	_	_	_	_
32	which	which	PRON	WDT	PronType=Rel	_	_	_	_
33	they	they	PRON	PRP	Case=Nom|Number=Plur|Person=3|PronType=Prs	_	_	_	_
34	can	can	AUX	MD	VerbForm=Fin	_	_	_	_
35	directly	directly	ADV	RB	_	_	_	_	_
36	regulate	regulate	VERB	VB	VerbForm=Inf	_	_	_	_
37	by	by	SCONJ	IN	_	_	_	_	_
38	binding	bind	VERB	VBG	VerbForm=Ger	_	_	_	_
39	to	to	ADP	IN	_	_	_	_	_
40	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
41	promoter	promoter	NOUN	NN	Number=Sing	_	_	_	_
42	site	site	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
43	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2617
# text = We propose that mutations of MDS1/EVI1 either by gene truncation resulting in the transcription repressor EVI1 or by gene fusion to AML1 lead to an altered cellular response to growth and differentiation factors that could result in leukemic transformation.
1	We	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
2	propose	propose	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
3	that	that	SCONJ	IN	_	_	_	_	_
4	mutations	mutation	NOUN	NNS	Number=Plur	_	_	_	_
5	of	of	ADP	IN	_	_	_	_	_
6	MDS1	MDS1	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
7	/	/	PUNCT	,	_	_	_	_	SpaceAfter=No
8	EVI1	EVI1	PROPN	NNP	Number=Sing	_	_	_	_
9	either	either	CCONJ	CC	_	_	_	_	_
10	by	by	ADP	IN	_	_	_	_	_
11	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
12	truncation	truncation	NOUN	NN	Number=Sing	_	_	_	_
13	resulting	result	VERB	VBG	VerbForm=Ger	_	_	_	_
14	in	in	ADP	IN	_	_	_	_	_
15	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
16	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
17	repressor	repressor	NOUN	NN	Number=Sing	_	_	_	_
18	EVI1	EVI1	PROPN	NNP	Number=Sing	_	_	_	_
19	or	or	CCONJ	CC	_	_	_	_	_
20	by	by	ADP	IN	_	_	_	_	_
21	gene	gene	ADJ	JJ	Degree=Pos	_	_	_	_
22	fusion	fusion	NOUN	NN	Number=Sing	_	_	_	_
23	to	to	ADP	IN	_	_	_	_	_
24	AML1	AML1	NUM	CD	NumType=Card	_	_	_	_
25	lead	lead	NOUN	NN	Number=Sing	_	_	_	_
26	to	to	ADP	IN	_	_	_	_	_
27	an	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
28	altered	alter	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
29	cellular	cellular	ADJ	JJ	Degree=Pos	_	_	_	_
30	response	response	NOUN	NN	Number=Sing	_	_	_	_
31	to	to	ADP	IN	_	_	_	_	_
32	growth	growth	NOUN	NN	Number=Sing	_	_	_	_
33	and	and	CCONJ	CC	_	_	_	_	_
34	differentiation	differentiation	NOUN	NN	Number=Sing	_	_	_	_
35	factors	factor	NOUN	NNS	Number=Plur	_	_	_	_
36	that	that	PRON	WDT	PronType=Rel	_	_	_	_
37	could	could	AUX	MD	VerbForm=Fin	_	_	_	_
38	result	result	VERB	VB	VerbForm=Inf	_	_	_	_
39	in	in	ADP	IN	_	_	_	_	_
40	leukemic	leukemic	ADJ	JJ	Degree=Pos	_	_	_	_
41	transformation	transformation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
42	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2618
# text = The different response of myeloid cells ectopically expressing the normal or the fusion protein to G-CSF and TGF-beta1 could depend on the different transactivation properties of these proteins resulting in divergent expression of downstream genes regulated by the two proteins.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	different	different	ADJ	JJ	Degree=Pos	_	_	_	_
3	response	response	NOUN	NN	Number=Sing	_	_	_	_
4	of	of	ADP	IN	_	_	_	_	_
5	myeloid	myeloid	ADJ	JJ	Degree=Pos	_	_	_	_
6	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
7	ectopically	ectopically	ADV	RB	_	_	_	_	_
8	expressing	express	VERB	VBG	VerbForm=Ger	_	_	_	_
9	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
10	normal	normal	ADJ	JJ	Degree=Pos	_	_	_	_
11	or	or	CCONJ	CC	_	_	_	_	_
12	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
13	fusion	fusion	NOUN	NN	Number=Sing	_	_	_	_
14	protein	protein	NOUN	NN	Number=Sing	_	_	_	_
15	to	to	ADP	IN	_	_	_	_	_
16	G-	G-	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
17	CSF	CSF	NOUN	NN	Number=Sing	_	_	_	_
18	and	and	CCONJ	CC	_	_	_	_	_
19	TGF	TGF	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
20	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
21	beta1	beta1	NOUN	NN	Number=Sing	_	_	_	_
22	could	could	AUX	MD	VerbForm=Fin	_	_	_	_
23	depend	depend	VERB	VB	VerbForm=Inf	_	_	_	_
24	on	on	ADP	IN	_	_	_	_	_
25	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
26	different	different	ADJ	JJ	Degree=Pos	_	_	_	_
27	transactivation	transactivation	NOUN	NN	Number=Sing	_	_	_	_
28	properties	property	NOUN	NNS	Number=Plur	_	_	_	_
29	of	of	ADP	IN	_	_	_	_	_
30	these	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
31	proteins	protein	NOUN	NNS	Number=Plur	_	_	_	_
32	resulting	result	VERB	VBG	VerbForm=Ger	_	_	_	_
33	in	in	ADP	IN	_	_	_	_	_
34	divergent	divergent	ADJ	JJ	Degree=Pos	_	_	_	_
35	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
36	of	of	ADP	IN	_	_	_	_	_
37	downstream	downstream	ADJ	JJ	Degree=Pos	_	_	_	_
38	genes	gene	NOUN	NNS	Number=Plur	_	_	_	_
39	regulated	regulate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
40	by	by	ADP	IN	_	_	_	_	_
41	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
42	two	two	NUM	CD	NumType=Card	_	_	_	_
43	proteins	protein	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
44	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 2619
# text = Document 003003280 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	003003280	003003280	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 2620
# text = [Glucocorticoid receptors in peripheral blood lymphocytes of patients with bronchial asthma] Quantitation of glucocorticoid receptors (GCR) and the study of their affinity for glucocorticosteroids (GCS) were made in peripheral blood lymphocytes of bronchial asthma (BA) patients in consideration of GCR treatment and serum levels of endogenous cortisol.
1	[	[	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
2	Glucocorticoid	Glucocorticoid	VERB	VB	Mood=Imp|VerbForm=Fin	_	_	_	_
3	receptors	receptor	NOUN	NNS	Number=Plur	_	_	_	_
4	in	in	ADP	IN	_	_	_	_	_
5	peripheral	peripheral	ADJ	JJ	Degree=Pos	_	_	_	_
6	blood	blood	NOUN	NN	Number=Sing	_	_	_	_
7	lymphocytes	lymphocyte	NOUN	NNS	Number=Plur	_	_	_	_
8	of	of	ADP	IN	_	_	_	_	_
9	patients	patient	NOUN	NNS	Number=Plur	_	_	_	_
10	with	with	ADP	IN	_	_	_	_	_
11	bronchial	bronchial	ADJ	JJ	Degree=Pos	_	_	_	_
12	asthma	asthma	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
13	]	]	PUNCT	-RRB-	_	_	_	_	SpacesAfter=\s\n
14	Quantitation	Quantitation	NOUN	NN	Number=Sing	_	_	_	_
15	of	of	ADP	IN	_	_	_	_	_
16	glucocorticoid	glucocorticoid	ADJ	JJ	Degree=Pos	_	_	_	_
17	receptors	receptor	NOUN	NNS	Number=Plur	_	_	_	_
18	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
19	GCR	GCR	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
20	)	)	PUNCT	-RRB-	_	_	_	_	_
21	and	and	CCONJ	CC	_	_	_	_	_
22	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
23	study	study	NOUN	NN	Number=Sing	_	_	_	_
24	of	of	ADP	IN	_	_	_	_	_
25	their	they	PRON	PRP$	Number=Plur|Person=3|Poss=Yes|PronType=Prs	_	_	_	_
26	affinity	affinity	NOUN	NN	Number=Sing	_	_	_	_
27	for	for	ADP	IN	_	_	_	_	_
28	glucocorticosteroids	glucocorticosteroid	NOUN	NNS	Number=Plur	_	_	_	_
29	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
30	GCS	Gc	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
31	)	)	PUNCT	-RRB-	_	_	_	_	_
32	were	be	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
33	made	make	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
34	in	in	ADP	IN	_	_	_	_	_
35	peripheral	peripheral	ADJ	JJ	Degree=Pos	_	_	_	_
36	blood	blood	NOUN	NN	Number=Sing	_	_	_	_
37	lymphocytes	lymphocyte	NOUN	NNS	Number=Plur	_	_	_	_
38	of	of	ADP	IN	_	_	_	_	_
39	bronchial	bronchial	ADJ	JJ	Degree=Pos	_	_	_	_
40	asthma	asthma	NOUN	NN	Number=Sing	_	_	_	_
41	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
42	BA	BA	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
43	)	)	PUNCT	-RRB-	_	_	_	_	_
44	patients	patient	NOUN	NNS	Number=Plur	_	_	_	_
45	in	in	ADP	IN	_	_	_	_	_
46	consideration	consideration	NOUN	NN	Number=Sing	_	_	_	_
47	of	of	ADP	IN	_	_	_	_	_
48	GCR	Gcr	ADJ	JJ	Degree=Pos	_	_	_	_
49	treatment	treatment	NOUN	NN	Number=Sing	_	_	_	_
50	and	and	CCONJ	CC	_	_	_	_	_
51	serum	serum	NOUN	NN	Number=Sing	_	_	_	_
52	levels	level	NOUN	NNS	Number=Plur	_	_	_	_
53	of	of	ADP	IN	_	_	_	_	_
54	endogenous	endogenous	ADJ	JJ	Degree=Pos	_	_	_	_
55	cortisol	cortisol	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
56	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2621
# text = It is stated that GCR of healthy controls and GCS-untreated patients outnumbered those of cortisol-dependent BA patients on hormone therapy.
1	It	it	PRON	PRP	Case=Nom|Gender=Neut|Number=Sing|Person=3|PronType=Prs	_	_	_	_
2	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
3	stated	state	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
4	that	that	SCONJ	IN	_	_	_	_	_
5	GCR	Gcr	ADP	IN	_	_	_	_	_
6	of	of	ADP	IN	_	_	_	_	_
7	healthy	healthy	ADJ	JJ	Degree=Pos	_	_	_	_
8	controls	control	NOUN	NNS	Number=Plur	_	_	_	_
9	and	and	CCONJ	CC	_	_	_	_	_
10	GCS	Gc	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
11	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
12	untreated	untreate	ADJ	JJ	Degree=Pos	_	_	_	_
13	patients	patient	NOUN	NNS	Number=Plur	_	_	_	_
14	outnumbered	outnumber	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
15	those	those	PRON	DT	Number=Plur|PronType=Dem	_	_	_	_
16	of	of	ADP	IN	_	_	_	_	_
17	cortisol	cortisol	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
18	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
19	dependent	dependent	ADJ	JJ	Degree=Pos	_	_	_	_
20	BA	Ba	NOUN	NN	Number=Sing	_	_	_	_
21	patients	patient	NOUN	NNS	Number=Plur	_	_	_	_
22	on	on	ADP	IN	_	_	_	_	_
23	hormone	hormone	NOUN	NN	Number=Sing	_	_	_	_
24	therapy	therapy	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
25	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2622
# text = Following discontinuation of glucocorticoid drugs GCR count in cortisol-dependent BA tends to rise.
1	Following	follow	VERB	VBG	VerbForm=Ger	_	_	_	_
2	discontinuation	discontinuation	NOUN	NN	Number=Sing	_	_	_	_
3	of	of	ADP	IN	_	_	_	_	_
4	glucocorticoid	glucocorticoid	ADJ	JJ	Degree=Pos	_	_	_	_
5	drugs	drug	NOUN	NNS	Number=Plur	_	_	_	_
6	GCR	Gcr	ADP	IN	_	_	_	_	_
7	count	count	NOUN	NN	Number=Sing	_	_	_	_
8	in	in	ADP	IN	_	_	_	_	_
9	cortisol	cortisol	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
10	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
11	dependent	dependent	ADJ	JJ	Degree=Pos	_	_	_	_
12	BA	Ba	NOUN	NN	Number=Sing	_	_	_	_
13	tends	tend	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
14	to	to	PART	TO	_	_	_	_	_
15	rise	rise	VERB	VB	VerbForm=Inf	_	_	_	SpaceAfter=No
16	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2623
# text = Endogenous cortisol has no effect on GCR level estimated by 3H-triamcinolone acetonide.
1	Endogenous	Endogenous	ADJ	JJ	Degree=Pos	_	_	_	_
2	cortisol	cortisol	NOUN	NN	Number=Sing	_	_	_	_
3	has	have	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
4	no	no	DET	DT	_	_	_	_	_
5	effect	effect	NOUN	NN	Number=Sing	_	_	_	_
6	on	on	ADP	IN	_	_	_	_	_
7	GCR	Gcr	ADJ	JJ	Degree=Pos	_	_	_	_
8	level	level	NOUN	NN	Number=Sing	_	_	_	_
9	estimated	estimate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
10	by	by	ADP	IN	_	_	_	_	_
11	3H	3h	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
12	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
13	triamcinolone	triamcinolone	ADJ	JJ	Degree=Pos	_	_	_	_
14	acetonide	acetonide	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
15	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 2624
# text = Document 003003282 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	003003282	003003282	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 2625
# text = Does activation of the TAL1 gene occur in a majority of patients with T-cell acute lymphoblastic leukemia?
1	Does	do	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
2	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
3	of	of	ADP	IN	_	_	_	_	_
4	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
5	TAL1	tAL1	NUM	CD	NumType=Card	_	_	_	_
6	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
7	occur	occur	NOUN	NN	Number=Sing	_	_	_	_
8	in	in	ADP	IN	_	_	_	_	_
9	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
10	majority	majority	NOUN	NN	Number=Sing	_	_	_	_
11	of	of	ADP	IN	_	_	_	_	_
12	patients	patient	NOUN	NNS	Number=Plur	_	_	_	_
13	with	with	ADP	IN	_	_	_	_	_
14	T-	t-	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
15	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
16	acute	acute	X	ADD	_	_	_	_	_
17	lymphoblastic	lymphoblastic	ADJ	JJ	Degree=Pos	_	_	_	_
18	leukemia	leukemia	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
19	?	?	PUNCT	.	_	_	_	_	_

# sent_id = 2626
# text = A pediatric oncology group study.
1	A	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
2	pediatric	pediatric	ADJ	JJ	Degree=Pos	_	_	_	_
3	oncology	oncology	NOUN	NN	Number=Sing	_	_	_	_
4	group	group	NOUN	NN	Number=Sing	_	_	_	_
5	study	study	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
6	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 2627
# text = Almost 25% of patients with T-cell acute lymphoblastic leukemia (T-ALL) have tumor-specific rearrangements of the TAL1 gene.
1	Almost	almost	ADV	RB	_	_	_	_	_
2	25	25	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
3	%	%	SYM	NN	Number=Sing	_	_	_	_
4	of	of	ADP	IN	_	_	_	_	_
5	patients	patient	NOUN	NNS	Number=Plur	_	_	_	_
6	with	with	ADP	IN	_	_	_	_	_
7	T-	t-	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
8	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
9	acute	acute	ADJ	JJ	Degree=Pos	_	_	_	_
10	lymphoblastic	lymphoblastic	ADJ	JJ	Degree=Pos	_	_	_	_
11	leukemia	leukemia	NOUN	NN	Number=Sing	_	_	_	_
12	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
13	T	t	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
14	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
15	ALL	all	ADV	RB	_	_	_	_	SpaceAfter=No
16	)	)	PUNCT	-RRB-	_	_	_	_	_
17	have	have	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
18	tumor-	tumor-	SYM	NFP	_	_	_	_	SpaceAfter=No
19	specific	specific	ADJ	JJ	Degree=Pos	_	_	_	_
20	rearrangements	rearrangement	NOUN	NNS	Number=Plur	_	_	_	_
21	of	of	ADP	IN	_	_	_	_	_
22	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
23	TAL1	tAL1	NOUN	NN	Number=Sing	_	_	_	_
24	gene	gene	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
25	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2628
# text = Although TAL1 expression has not been observed in normal lymphocytes, TAL1 gene products are readily detected in leukemic cells that harbor a rearranged TAL1 allele.
1	Although	although	SCONJ	IN	_	_	_	_	_
2	TAL1	TAL1	NUM	CD	NumType=Card	_	_	_	_
3	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
4	has	have	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
5	not	not	PART	RB	_	_	_	_	_
6	been	be	AUX	VBN	Tense=Past|VerbForm=Part	_	_	_	_
7	observed	observe	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
8	in	in	ADP	IN	_	_	_	_	_
9	normal	normal	ADJ	JJ	Degree=Pos	_	_	_	_
10	lymphocytes	lymphocyte	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
11	,	,	PUNCT	,	_	_	_	_	_
12	TAL1	TAL1	NUM	CD	NumType=Card	_	_	_	_
13	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
14	products	product	NOUN	NNS	Number=Plur	_	_	_	_
15	are	be	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
16	readily	readily	ADV	RB	_	_	_	_	_
17	detected	detect	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
18	in	in	ADP	IN	_	_	_	_	_
19	leukemic	leukemic	ADJ	JJ	Degree=Pos	_	_	_	_
20	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
21	that	that	PRON	WDT	PronType=Rel	_	_	_	_
22	harbor	harbor	VERB	VB	VerbForm=Inf	_	_	_	_
23	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
24	rearranged	rearrange	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
25	TAL1	tAL1	NOUN	NN	Number=Sing	_	_	_	_
26	allele	allele	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
27	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2629
# text = Hence, it has been proposed that ectopic expression of TAL1 promotes the development of T-ALL.
1	Hence	hence	ADV	RB	_	_	_	_	SpaceAfter=No
2	,	,	PUNCT	,	_	_	_	_	_
3	it	it	PRON	PRP	Case=Nom|Gender=Neut|Number=Sing|Person=3|PronType=Prs	_	_	_	_
4	has	have	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
5	been	be	AUX	VBN	Tense=Past|VerbForm=Part	_	_	_	_
6	proposed	propose	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
7	that	that	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
8	ectopic	ectopic	ADJ	JJ	Degree=Pos	_	_	_	_
9	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
10	of	of	ADP	IN	_	_	_	_	_
11	TAL1	TAL1	NUM	CD	NumType=Card	_	_	_	_
12	promotes	promote	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
13	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
14	development	development	NOUN	NN	Number=Sing	_	_	_	_
15	of	of	ADP	IN	_	_	_	_	_
16	T-	T-	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
17	ALL	all	ADV	RB	_	_	_	_	SpaceAfter=No
18	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2630
# text = In this report, we show that TAL1 is expressed in the leukemic cells of most patients with T-ALL, including many that do not display an apparent TAL1 gene alteration.
1	In	in	ADP	IN	_	_	_	_	_
2	this	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
3	report	report	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
4	,	,	PUNCT	,	_	_	_	_	_
5	we	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
6	show	show	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
7	that	that	SCONJ	IN	_	_	_	_	_
8	TAL1	TAL1	PROPN	NNP	Number=Sing	_	_	_	_
9	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
10	expressed	express	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
11	in	in	ADP	IN	_	_	_	_	_
12	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
13	leukemic	leukemic	ADJ	JJ	Degree=Pos	_	_	_	_
14	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
15	of	of	ADP	IN	_	_	_	_	_
16	most	most	ADJ	JJS	Degree=Sup	_	_	_	_
17	patients	patient	NOUN	NNS	Number=Plur	_	_	_	_
18	with	with	ADP	IN	_	_	_	_	_
19	T	t	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
20	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
21	ALL	all	ADV	RB	_	_	_	_	SpaceAfter=No
22	,	,	PUNCT	,	_	_	_	_	_
23	including	include	VERB	VBG	VerbForm=Ger	_	_	_	_
24	many	many	ADJ	JJ	Degree=Pos	_	_	_	_
25	that	that	PRON	WDT	PronType=Rel	_	_	_	_
26	do	do	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
27	not	not	PART	RB	_	_	_	_	_
28	display	display	VERB	VB	VerbForm=Inf	_	_	_	_
29	an	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
30	apparent	apparent	ADJ	JJ	Degree=Pos	_	_	_	_
31	TAL1	tAL1	NOUN	NN	Number=Sing	_	_	_	_
32	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
33	alteration	alteration	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
34	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2631
# text = A polymorphic dinucleotide repeat in the transcribed sequences of TAL1 was used to determine the allele specificity of TAL1 transcription in primary T-ALL cells.
1	A	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
2	polymorphic	polymorphic	ADJ	JJ	Degree=Pos	_	_	_	_
3	dinucleotide	dinucleotide	NOUN	NN	Number=Sing	_	_	_	_
4	repeat	repeat	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
5	in	in	ADP	IN	_	_	_	_	_
6	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
7	transcribed	transcribe	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
8	sequences	sequence	NOUN	NNS	Number=Plur	_	_	_	_
9	of	of	ADP	IN	_	_	_	_	_
10	TAL1	tAL1	PROPN	NNP	Number=Sing	_	_	_	_
11	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
12	used	use	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
13	to	to	PART	TO	_	_	_	_	_
14	determine	determine	VERB	VB	VerbForm=Inf	_	_	_	_
15	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
16	allele	allele	NOUN	NN	Number=Sing	_	_	_	_
17	specificity	specificity	NOUN	NN	Number=Sing	_	_	_	_
18	of	of	ADP	IN	_	_	_	_	_
19	TAL1	TAL1	NUM	CD	NumType=Card	_	_	_	_
20	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
21	in	in	ADP	IN	_	_	_	_	_
22	primary	primary	ADJ	JJ	Degree=Pos	_	_	_	_
23	T	t	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
24	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
25	ALL	all	DET	DT	_	_	_	_	_
26	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
27	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2632
# text = Monoallelic expression of TAL1 was observed in the leukemic cells of all patients (8 of 8) bearing a TAL1 gene rearrangement.
1	Monoallelic	Monoallelic	ADJ	JJ	Degree=Pos	_	_	_	_
2	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
3	of	of	ADP	IN	_	_	_	_	_
4	TAL1	tAL1	PROPN	NNP	Number=Sing	_	_	_	_
5	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
6	observed	observe	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
7	in	in	ADP	IN	_	_	_	_	_
8	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
9	leukemic	leukemic	ADJ	JJ	Degree=Pos	_	_	_	_
10	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
11	of	of	ADP	IN	_	_	_	_	_
12	all	all	DET	DT	_	_	_	_	_
13	patients	patient	NOUN	NNS	Number=Plur	_	_	_	_
14	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
15	8	8	NUM	CD	NumType=Card	_	_	_	_
16	of	of	ADP	IN	_	_	_	_	_
17	8	8	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
18	)	)	PUNCT	-RRB-	_	_	_	_	_
19	bearing	bear	VERB	VBG	VerbForm=Ger	_	_	_	_
20	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
21	TAL1	TAL1	NUM	CD	NumType=Card	_	_	_	_
22	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
23	rearrangement	rearrangement	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
24	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2633
# text = In the leukemic cells of patients without detectable TAL1 rearrangements, TAL1 transcription occurred in either a monoallelic (3 of 7 patients) or a biallelic (4 of 7 patients) fashion.
1	In	in	ADP	IN	_	_	_	_	_
2	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
3	leukemic	leukemic	ADJ	JJ	Degree=Pos	_	_	_	_
4	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
5	of	of	ADP	IN	_	_	_	_	_
6	patients	patient	NOUN	NNS	Number=Plur	_	_	_	_
7	without	without	ADP	IN	_	_	_	_	_
8	detectable	detectable	ADJ	JJ	Degree=Pos	_	_	_	_
9	TAL1	tAL1	NUM	CD	NumType=Card	_	_	_	_
10	rearrangements	rearrangement	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
11	,	,	PUNCT	,	_	_	_	_	_
12	TAL1	TAL1	NUM	CD	NumType=Card	_	_	_	_
13	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
14	occurred	occur	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
15	in	in	ADP	IN	_	_	_	_	_
16	either	either	CCONJ	CC	_	_	_	_	_
17	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
18	monoallelic	monoallelic	NOUN	NN	Number=Sing	_	_	_	_
19	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
20	3	3	NUM	CD	NumType=Card	_	_	_	_
21	of	of	ADP	IN	_	_	_	_	_
22	7	7	NUM	CD	NumType=Card	_	_	_	_
23	patients	patient	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
24	)	)	PUNCT	-RRB-	_	_	_	_	_
25	or	or	CCONJ	CC	_	_	_	_	_
26	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
27	biallelic	biallelic	NOUN	NN	Number=Sing	_	_	_	_
28	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
29	4	4	NUM	CD	NumType=Card	_	_	_	_
30	of	of	ADP	IN	_	_	_	_	_
31	7	7	NUM	CD	NumType=Card	_	_	_	_
32	patients	patient	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
33	)	)	PUNCT	-RRB-	_	_	_	_	_
34	fashion	fashion	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
35	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2634
# text = Thus, TAL1 activation in these patients may result from subtle alterations in cis-acting regulatory sequences (affecting expression of a single TAL1 allele) or changes in trans-acting factors that control TAL1 transcription (affecting expression of both TAL1 alleles).
1	Thus	thus	ADV	RB	_	_	_	_	SpaceAfter=No
2	,	,	PUNCT	,	_	_	_	_	_
3	TAL1	TAL1	NUM	CD	NumType=Card	_	_	_	_
4	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
5	in	in	ADP	IN	_	_	_	_	_
6	these	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
7	patients	patient	NOUN	NNS	Number=Plur	_	_	_	_
8	may	may	AUX	MD	VerbForm=Fin	_	_	_	_
9	result	result	VERB	VB	VerbForm=Inf	_	_	_	_
10	from	from	ADP	IN	_	_	_	_	_
11	subtle	subtle	ADJ	JJ	Degree=Pos	_	_	_	_
12	alterations	alteration	NOUN	NNS	Number=Plur	_	_	_	_
13	in	in	ADP	IN	_	_	_	_	_
14	cis	cis	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
15	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
16	acting	act	VERB	VBG	VerbForm=Ger	_	_	_	_
17	regulatory	regulatory	ADJ	JJ	Degree=Pos	_	_	_	_
18	sequences	sequence	NOUN	NNS	Number=Plur	_	_	_	_
19	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
20	affecting	affect	VERB	VBG	VerbForm=Ger	_	_	_	_
21	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
22	of	of	ADP	IN	_	_	_	_	_
23	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
24	single	single	ADJ	JJ	Degree=Pos	_	_	_	_
25	TAL1	tAL1	NOUN	NN	Number=Sing	_	_	_	_
26	allele	allele	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
27	)	)	PUNCT	-RRB-	_	_	_	_	_
28	or	or	CCONJ	CC	_	_	_	_	_
29	changes	change	NOUN	NNS	Number=Plur	_	_	_	_
30	in	in	ADP	IN	_	_	_	_	_
31	trans	tran	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
32	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
33	acting	act	VERB	VBG	VerbForm=Ger	_	_	_	_
34	factors	factor	NOUN	NNS	Number=Plur	_	_	_	_
35	that	that	PRON	WDT	PronType=Rel	_	_	_	_
36	control	control	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
37	TAL1	TAL1	NUM	CD	NumType=Card	_	_	_	_
38	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
39	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
40	affecting	affect	VERB	VBG	VerbForm=Ger	_	_	_	_
41	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
42	of	of	ADP	IN	_	_	_	_	_
43	both	both	DET	DT	_	_	_	_	_
44	TAL1	TAL1	NUM	CD	NumType=Card	_	_	_	_
45	alleles	allele	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
46	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
47	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 2635
# text = Document 003003283 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	003003283	003003283	NUM	CD	NumType=Card	_	_	_	_
3	ends.	ends.	NOUN	NN	Number=Sing	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 2636
# text = BCL-6 and the molecular pathogenesis of B-cell lymphoma.
1	BCL	BCL	INTJ	UH	_	_	_	_	SpaceAfter=No
2	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
3	6	6	NUM	CD	NumType=Card	_	_	_	_
4	and	and	CCONJ	CC	_	_	_	_	_
5	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
6	molecular	molecular	ADJ	JJ	Degree=Pos	_	_	_	_
7	pathogenesis	pathogenesis	NOUN	NN	Number=Sing	_	_	_	_
8	of	of	ADP	IN	_	_	_	_	_
9	B-	b-	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
10	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
11	lymphoma	lymphoma	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
12	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 2637
# text = The results presented identify the first genetic lesion associated with DLCL, the most clinically relevant form of NHL.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	results	result	NOUN	NNS	Number=Plur	_	_	_	_
3	presented	present	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
4	identify	identify	VERB	VB	VerbForm=Inf	_	_	_	_
5	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
6	first	first	ADV	RBS	_	_	_	_	_
7	genetic	genetic	ADJ	JJ	Degree=Pos	_	_	_	_
8	lesion	lesion	NOUN	NN	Number=Sing	_	_	_	_
9	associated	associate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
10	with	with	ADP	IN	_	_	_	_	_
11	DLCL	DLCL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
12	,	,	PUNCT	,	_	_	_	_	_
13	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
14	most	most	ADV	RBS	_	_	_	_	_
15	clinically	clinically	ADV	RB	_	_	_	_	_
16	relevant	relevant	ADJ	JJ	Degree=Pos	_	_	_	_
17	form	form	NOUN	NN	Number=Sing	_	_	_	_
18	of	of	ADP	IN	_	_	_	_	_
19	NHL	NHL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
20	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2638
# text = Although no proof yet exists of a role for these lesions in DLCL pathogenesis, the feature of the BCL-6 gene product, its specific pattern of expression in B cells, and the clustering of lesions disrupting its regulatory domain strongly suggest that deregulation of BCL-6 expression may contribute to DLCL development.
1	Although	although	SCONJ	IN	_	_	_	_	_
2	no	no	DET	DT	_	_	_	_	_
3	proof	proof	NOUN	NN	Number=Sing	_	_	_	_
4	yet	yet	ADV	RB	_	_	_	_	_
5	exists	exist	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
6	of	of	ADP	IN	_	_	_	_	_
7	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
8	role	role	NOUN	NN	Number=Sing	_	_	_	_
9	for	for	ADP	IN	_	_	_	_	_
10	these	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
11	lesions	lesion	NOUN	NNS	Number=Plur	_	_	_	_
12	in	in	ADP	IN	_	_	_	_	_
13	DLCL	DLCL	PROPN	NNP	Number=Sing	_	_	_	_
14	pathogenesis	pathogenesis	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
15	,	,	PUNCT	,	_	_	_	_	_
16	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
17	feature	feature	NOUN	NN	Number=Sing	_	_	_	_
18	of	of	ADP	IN	_	_	_	_	_
19	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
20	BCL	BCL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
21	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
22	6	6	NUM	CD	NumType=Card	_	_	_	_
23	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
24	product	product	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
25	,	,	PUNCT	,	_	_	_	_	_
26	its	its	PRON	PRP$	Gender=Neut|Number=Sing|Person=3|Poss=Yes|PronType=Prs	_	_	_	_
27	specific	specific	ADJ	JJ	Degree=Pos	_	_	_	_
28	pattern	pattern	NOUN	NN	Number=Sing	_	_	_	_
29	of	of	ADP	IN	_	_	_	_	_
30	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
31	in	in	ADP	IN	_	_	_	_	_
32	B	b	ADJ	JJ	Degree=Pos	_	_	_	_
33	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
34	,	,	PUNCT	,	_	_	_	_	_
35	and	and	CCONJ	CC	_	_	_	_	_
36	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
37	clustering	clustering	NOUN	NN	Number=Sing	_	_	_	_
38	of	of	ADP	IN	_	_	_	_	_
39	lesions	lesion	NOUN	NNS	Number=Plur	_	_	_	_
40	disrupting	disrupt	VERB	VBG	VerbForm=Ger	_	_	_	_
41	its	its	PRON	PRP$	Gender=Neut|Number=Sing|Person=3|Poss=Yes|PronType=Prs	_	_	_	_
42	regulatory	regulatory	ADJ	JJ	Degree=Pos	_	_	_	_
43	domain	domain	NOUN	NN	Number=Sing	_	_	_	_
44	strongly	strongly	ADV	RB	_	_	_	_	_
45	suggest	suggest	VERB	VB	Mood=Imp|VerbForm=Fin	_	_	_	_
46	that	that	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
47	deregulation	deregulation	NOUN	NN	Number=Sing	_	_	_	_
48	of	of	ADP	IN	_	_	_	_	_
49	BCL	BCL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
50	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
51	6	6	NUM	CD	NumType=Card	_	_	_	_
52	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
53	may	may	AUX	MD	VerbForm=Fin	_	_	_	_
54	contribute	contribute	VERB	VB	VerbForm=Inf	_	_	_	_
55	to	to	PART	TO	_	_	_	_	_
56	DLCL	Dlcl	VERB	VB	VerbForm=Inf	_	_	_	_
57	development	development	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
58	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2639
# text = A more precise definition of the role of BCL-6 in normal and neoplastic B-cell development is the goal of ongoing study of transgenic mice engineered either to express BCL-6 under heterologous promoters or lacking BCL-6 function due to targeted deletions.
1	A	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
2	more	more	ADV	RBR	_	_	_	_	_
3	precise	precise	ADJ	JJ	Degree=Pos	_	_	_	_
4	definition	definition	NOUN	NN	Number=Sing	_	_	_	_
5	of	of	ADP	IN	_	_	_	_	_
6	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
7	role	role	NOUN	NN	Number=Sing	_	_	_	_
8	of	of	ADP	IN	_	_	_	_	_
9	BCL	BCL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
10	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
11	6	6	NUM	CD	NumType=Card	_	_	_	_
12	in	in	ADP	IN	_	_	_	_	_
13	normal	normal	ADJ	JJ	Degree=Pos	_	_	_	_
14	and	and	CCONJ	CC	_	_	_	_	_
15	neoplastic	neoplastic	ADJ	JJ	Degree=Pos	_	_	_	_
16	B	b	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
17	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
18	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
19	development	development	NOUN	NN	Number=Sing	_	_	_	_
20	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
21	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
22	goal	goal	NOUN	NN	Number=Sing	_	_	_	_
23	of	of	ADP	IN	_	_	_	_	_
24	ongoing	ongoing	ADJ	JJ	Degree=Pos	_	_	_	_
25	study	study	NOUN	NN	Number=Sing	_	_	_	_
26	of	of	ADP	IN	_	_	_	_	_
27	transgenic	transgenic	ADJ	JJ	Degree=Pos	_	_	_	_
28	mice	mouse	NOUN	NNS	Number=Plur	_	_	_	_
29	engineered	engineer	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
30	either	either	ADV	RB	_	_	_	_	_
31	to	to	PART	TO	_	_	_	_	_
32	express	express	VERB	VB	VerbForm=Inf	_	_	_	_
33	BCL	BCL	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
34	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
35	6	6	NUM	CD	NumType=Card	_	_	_	_
36	under	under	ADP	IN	_	_	_	_	_
37	heterologous	heterologous	ADJ	JJ	Degree=Pos	_	_	_	_
38	promoters	promoter	NOUN	NNS	Number=Plur	_	_	_	_
39	or	or	CCONJ	CC	_	_	_	_	_
40	lacking	lack	VERB	VBG	VerbForm=Ger	_	_	_	_
41	BCL	BCL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
42	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
43	6	6	NUM	CD	NumType=Card	_	_	_	_
44	function	function	NOUN	NN	Number=Sing	_	_	_	_
45	due	due	ADP	IN	_	_	_	_	_
46	to	to	ADP	IN	_	_	_	_	_
47	targeted	target	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
48	deletions	deletion	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
49	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2640
# text = In addition to contributing to the understanding of DLCL pathogenesis, the identification of BCL-6 lesions may have relevant clinical implications.
1	In	in	ADP	IN	_	_	_	_	_
2	addition	addition	NOUN	NN	Number=Sing	_	_	_	_
3	to	to	SCONJ	IN	_	_	_	_	_
4	contributing	contribute	VERB	VBG	VerbForm=Ger	_	_	_	_
5	to	to	ADP	IN	_	_	_	_	_
6	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
7	understanding	understanding	NOUN	NN	Number=Sing	_	_	_	_
8	of	of	ADP	IN	_	_	_	_	_
9	DLCL	DLCL	PROPN	NNP	Number=Sing	_	_	_	_
10	pathogenesis	pathogenesis	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
11	,	,	PUNCT	,	_	_	_	_	_
12	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
13	identification	identification	NOUN	NN	Number=Sing	_	_	_	_
14	of	of	ADP	IN	_	_	_	_	_
15	BCL	BCL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
16	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
17	6	6	NUM	CD	NumType=Card	_	_	_	_
18	lesions	lesion	NOUN	NNS	Number=Plur	_	_	_	_
19	may	may	AUX	MD	VerbForm=Fin	_	_	_	_
20	have	have	VERB	VB	VerbForm=Inf	_	_	_	_
21	relevant	relevant	ADJ	JJ	Degree=Pos	_	_	_	_
22	clinical	clinical	ADJ	JJ	Degree=Pos	_	_	_	_
23	implications	implication	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
24	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2641
# text = DLCL represent a heterogeneous group of neoplasms which are treated homogeneously despite the fact that only 50% of patients experience long-term disease-free survival (Schneider et al.
1	DLCL	DLCL	AUX	MD	VerbForm=Fin	_	_	_	_
2	represent	represent	VERB	VB	VerbForm=Inf	_	_	_	_
3	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
4	heterogeneous	heterogeneous	ADJ	JJ	Degree=Pos	_	_	_	_
5	group	group	NOUN	NN	Number=Sing	_	_	_	_
6	of	of	ADP	IN	_	_	_	_	_
7	neoplasms	neoplasm	NOUN	NNS	Number=Plur	_	_	_	_
8	which	which	PRON	WDT	PronType=Rel	_	_	_	_
9	are	be	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
10	treated	treat	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
11	homogeneously	homogeneously	ADV	RB	_	_	_	_	_
12	despite	despite	ADP	IN	_	_	_	_	_
13	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
14	fact	fact	NOUN	NN	Number=Sing	_	_	_	_
15	that	that	SCONJ	IN	_	_	_	_	_
16	only	only	ADV	RB	_	_	_	_	_
17	50	50	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
18	%	%	SYM	NN	Number=Sing	_	_	_	_
19	of	of	ADP	IN	_	_	_	_	_
20	patients	patient	NOUN	NN	Number=Sing	_	_	_	_
21	experience	experience	NOUN	NN	Number=Sing	_	_	_	_
22	long	long	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
23	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
24	term	term	NOUN	NN	Number=Sing	_	_	_	_
25	disease	disease	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
26	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
27	free	free	ADJ	JJ	Degree=Pos	_	_	_	_
28	survival	survival	NOUN	NN	Number=Sing	_	_	_	_
29	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
30	Schneider	Schneider	NOUN	NN	Number=Sing	_	_	_	_
31	et	et	X	FW	_	_	_	_	_
32	al.	al.	X	FW	_	_	_	_	_

# sent_id = 2642
# text = 1990).
1	1990	1990	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
2	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
3	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2643
# text = The fact that BCL-6 rearrangements identify biologically and clinically distinct subsets of DLCL suggests that these lesions may be useful as markers in selection of differential therapeutic strategies based on different risk groups.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	fact	fact	NOUN	NN	Number=Sing	_	_	_	_
3	that	that	PRON	WDT	PronType=Rel	_	_	_	_
4	BCL	BCL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
5	-	-	SYM	SYM	_	_	_	_	SpaceAfter=No
6	6	6	NUM	CD	NumType=Card	_	_	_	_
7	rearrangements	rearrangement	NOUN	NNS	Number=Plur	_	_	_	_
8	identify	identify	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
9	biologically	biologically	ADV	RB	_	_	_	_	_
10	and	and	CCONJ	CC	_	_	_	_	_
11	clinically	clinically	ADV	RB	_	_	_	_	_
12	distinct	distinct	ADJ	JJ	Degree=Pos	_	_	_	_
13	subsets	subset	NOUN	NNS	Number=Plur	_	_	_	_
14	of	of	ADP	IN	_	_	_	_	_
15	DLCL	DLCL	PROPN	NNP	Number=Sing	_	_	_	_
16	suggests	suggest	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
17	that	that	SCONJ	IN	_	_	_	_	_
18	these	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
19	lesions	lesion	NOUN	NNS	Number=Plur	_	_	_	_
20	may	may	AUX	MD	VerbForm=Fin	_	_	_	_
21	be	be	AUX	VB	VerbForm=Inf	_	_	_	_
22	useful	useful	ADJ	JJ	Degree=Pos	_	_	_	_
23	as	as	SCONJ	IN	_	_	_	_	_
24	markers	marker	NOUN	NNS	Number=Plur	_	_	_	_
25	in	in	ADP	IN	_	_	_	_	_
26	selection	selection	NOUN	NN	Number=Sing	_	_	_	_
27	of	of	ADP	IN	_	_	_	_	_
28	differential	differential	ADJ	JJ	Degree=Pos	_	_	_	_
29	therapeutic	therapeutic	ADJ	JJ	Degree=Pos	_	_	_	_
30	strategies	strategy	NOUN	NNS	Number=Plur	_	_	_	_
31	based	base	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
32	on	on	ADP	IN	_	_	_	_	_
33	different	different	ADJ	JJ	Degree=Pos	_	_	_	_
34	risk	risk	NOUN	NN	Number=Sing	_	_	_	_
35	groups	group	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
36	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2644
# text = Furthermore, the BCL-6 rearrangements can be used to identify and monitor the malignant clone with sensitive PCR-based techniques.
1	Furthermore	furthermore	ADV	RB	_	_	_	_	SpaceAfter=No
2	,	,	PUNCT	,	_	_	_	_	_
3	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
4	BCL	BCL	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
5	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
6	6	6	NUM	CD	NumType=Card	_	_	_	_
7	rearrangements	rearrangement	NOUN	NNS	Number=Plur	_	_	_	_
8	can	can	AUX	MD	VerbForm=Fin	_	_	_	_
9	be	be	AUX	VB	VerbForm=Inf	_	_	_	_
10	used	use	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
11	to	to	PART	TO	_	_	_	_	_
12	identify	identify	VERB	VB	VerbForm=Inf	_	_	_	_
13	and	and	CCONJ	CC	_	_	_	_	_
14	monitor	monitor	VERB	VB	VerbForm=Inf	_	_	_	_
15	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
16	malignant	malignant	ADJ	JJ	Degree=Pos	_	_	_	_
17	clone	clone	NOUN	NN	Number=Sing	_	_	_	_
18	with	with	ADP	IN	_	_	_	_	_
19	sensitive	sensitive	ADJ	JJ	Degree=Pos	_	_	_	_
20	PCR	Pcr	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
21	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
22	based	base	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
23	techniques	technique	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
24	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2645
# text = Since clinical remission has been observed in a significant fraction of DLCL cases, these markers may serve as critical tools for sensitive monitoring of minimal residual disease and early diagnosis of relapse (Gribben et al.
1	Since	since	ADP	IN	_	_	_	_	_
2	clinical	clinical	ADJ	JJ	Degree=Pos	_	_	_	_
3	remission	remission	NOUN	NN	Number=Sing	_	_	_	_
4	has	have	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
5	been	be	AUX	VBN	Tense=Past|VerbForm=Part	_	_	_	_
6	observed	observe	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
7	in	in	ADP	IN	_	_	_	_	_
8	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
9	significant	significant	ADJ	JJ	Degree=Pos	_	_	_	_
10	fraction	fraction	NOUN	NN	Number=Sing	_	_	_	_
11	of	of	ADP	IN	_	_	_	_	_
12	DLCL	Dlcl	ADJ	JJ	Degree=Pos	_	_	_	_
13	cases	case	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
14	,	,	PUNCT	,	_	_	_	_	_
15	these	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
16	markers	marker	NOUN	NNS	Number=Plur	_	_	_	_
17	may	may	AUX	MD	VerbForm=Fin	_	_	_	_
18	serve	serve	VERB	VB	VerbForm=Inf	_	_	_	_
19	as	as	ADP	IN	_	_	_	_	_
20	critical	critical	ADJ	JJ	Degree=Pos	_	_	_	_
21	tools	tool	NOUN	NNS	Number=Plur	_	_	_	_
22	for	for	ADP	IN	_	_	_	_	_
23	sensitive	sensitive	ADJ	JJ	Degree=Pos	_	_	_	_
24	monitoring	monitoring	NOUN	NN	Number=Sing	_	_	_	_
25	of	of	ADP	IN	_	_	_	_	_
26	minimal	minimal	ADJ	JJ	Degree=Pos	_	_	_	_
27	residual	residual	ADJ	JJ	Degree=Pos	_	_	_	_
28	disease	disease	NOUN	NN	Number=Sing	_	_	_	_
29	and	and	CCONJ	CC	_	_	_	_	_
30	early	early	ADJ	JJ	Degree=Pos	_	_	_	_
31	diagnosis	diagnosis	NOUN	NN	Number=Sing	_	_	_	_
32	of	of	ADP	IN	_	_	_	_	_
33	relapse	relapse	NOUN	NN	Number=Sing	_	_	_	_
34	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
35	Gribben	Gribben	PROPN	NNP	Number=Sing	_	_	_	_
36	et	et	X	FW	_	_	_	_	_
37	al.	al.	X	FW	_	_	_	_	_

# sent_id = 2646
# text = 1993).
1	1993	1993	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
2	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
3	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 2647
# text = Document 003003284 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	003003284	003003284	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 2648
# text = Attenuation of gamma interferon-induced tyrosine phosphorylation in mononuclear phagocytes infected with Leishmania donovani: selective inhibition of signaling through Janus kinases and Stat1.
1	Attenuation	Attenuation	NOUN	NN	Number=Sing	_	_	_	_
2	of	of	ADP	IN	_	_	_	_	_
3	gamma	gamma	NOUN	NN	Number=Sing	_	_	_	_
4	interferon	interferon	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
5	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
6	induced	induce	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
7	tyrosine	tyrosine	NOUN	NN	Number=Sing	_	_	_	_
8	phosphorylation	phosphorylation	NOUN	NN	Number=Sing	_	_	_	_
9	in	in	ADP	IN	_	_	_	_	_
10	mononuclear	mononuclear	ADJ	JJ	Degree=Pos	_	_	_	_
11	phagocytes	phagocyte	NOUN	NNS	Number=Plur	_	_	_	_
12	infected	infect	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
13	with	with	ADP	IN	_	_	_	_	_
14	Leishmania	Leishmania	PROPN	NNP	Number=Sing	_	_	_	_
15	donovani	donovani	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
16	:	:	PUNCT	:	_	_	_	_	_
17	selective	selective	ADJ	JJ	Degree=Pos	_	_	_	_
18	inhibition	inhibition	NOUN	NN	Number=Sing	_	_	_	_
19	of	of	SCONJ	IN	_	_	_	_	_
20	signaling	signal	VERB	VBG	VerbForm=Ger	_	_	_	_
21	through	through	ADP	IN	_	_	_	_	_
22	Janus	Janus	PROPN	NNP	Number=Sing	_	_	_	_
23	kinases	kinase	NOUN	NNS	Number=Plur	_	_	_	_
24	and	and	CCONJ	CC	_	_	_	_	_
25	Stat1	stat1	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
26	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 2649
# text = The induction of gene transcription in response to gamma interferon is impaired in mononuclear phagocytes infected with Leishmania donovani, and the mechanisms involved are not fully understood.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	induction	induction	NOUN	NN	Number=Sing	_	_	_	_
3	of	of	ADP	IN	_	_	_	_	_
4	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
5	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
6	in	in	ADP	IN	_	_	_	_	_
7	response	response	NOUN	NN	Number=Sing	_	_	_	_
8	to	to	ADP	IN	_	_	_	_	_
9	gamma	gamma	NOUN	NN	Number=Sing	_	_	_	_
10	interferon	interferon	NOUN	NN	Number=Sing	_	_	_	_
11	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
12	impaired	impaire	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
13	in	in	ADP	IN	_	_	_	_	_
14	mononuclear	mononuclear	ADJ	JJ	Degree=Pos	_	_	_	_
15	phagocytes	phagocyte	NOUN	NNS	Number=Plur	_	_	_	_
16	infected	infect	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
17	with	with	ADP	IN	_	_	_	_	_
18	Leishmania	Leishmania	PROPN	NNP	Number=Sing	_	_	_	_
19	donovani	donovani	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
20	,	,	PUNCT	,	_	_	_	_	_
21	and	and	CCONJ	CC	_	_	_	_	_
22	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
23	mechanisms	mechanism	NOUN	NNS	Number=Plur	_	_	_	_
24	involved	involve	ADJ	JJ	Degree=Pos	_	_	_	_
25	are	be	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
26	not	not	PART	RB	_	_	_	_	_
27	fully	fully	ADV	RB	_	_	_	_	_
28	understood	understand	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	SpaceAfter=No
29	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2650
# text = The changes in gene expression brought about by gamma interferon are thought to involve transient increases in the activities of cellular protein tyrosine kinases, including the Janus kinases Jak1 and Jak2, leading to tyrosine phosphorylation of the transcription factor Stat1.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	changes	change	NOUN	NNS	Number=Plur	_	_	_	_
3	in	in	ADP	IN	_	_	_	_	_
4	gene	gene	ADJ	JJ	Degree=Pos	_	_	_	_
5	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
6	brought	bring	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
7	about	about	ADV	RB	_	_	_	_	_
8	by	by	ADP	IN	_	_	_	_	_
9	gamma	gamma	NOUN	NN	Number=Sing	_	_	_	_
10	interferon	interferon	NOUN	NN	Number=Sing	_	_	_	_
11	are	be	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
12	thought	think	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
13	to	to	PART	TO	_	_	_	_	_
14	involve	involve	VERB	VB	VerbForm=Inf	_	_	_	_
15	transient	transient	ADJ	JJ	Degree=Pos	_	_	_	_
16	increases	increase	NOUN	NNS	Number=Plur	_	_	_	_
17	in	in	ADP	IN	_	_	_	_	_
18	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
19	activities	activity	NOUN	NNS	Number=Plur	_	_	_	_
20	of	of	ADP	IN	_	_	_	_	_
21	cellular	cellular	ADJ	JJ	Degree=Pos	_	_	_	_
22	protein	protein	NOUN	NN	Number=Sing	_	_	_	_
23	tyrosine	tyrosine	NOUN	NN	Number=Sing	_	_	_	_
24	kinases	kinase	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
25	,	,	PUNCT	,	_	_	_	_	_
26	including	include	VERB	VBG	VerbForm=Ger	_	_	_	_
27	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
28	Janus	Janus	PROPN	NNP	Number=Sing	_	_	_	_
29	kinases	kinase	PROPN	NNPS	Number=Plur	_	_	_	_
30	Jak1	Jak1	PROPN	NNP	Number=Sing	_	_	_	_
31	and	and	CCONJ	CC	_	_	_	_	_
32	Jak2	Jak2	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
33	,	,	PUNCT	,	_	_	_	_	_
34	leading	lead	VERB	VBG	VerbForm=Ger	_	_	_	_
35	to	to	PART	TO	_	_	_	_	_
36	tyrosine	tyrosine	VERB	VB	VerbForm=Inf	_	_	_	_
37	phosphorylation	phosphorylation	NOUN	NN	Number=Sing	_	_	_	_
38	of	of	ADP	IN	_	_	_	_	_
39	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
40	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
41	factor	factor	NOUN	NN	Number=Sing	_	_	_	_
42	Stat1	stat1	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
43	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2651
# text = To investigate the mechanisms accounting for the impaired responses to gamma interferon, a model system for examining overall changes in protein tyrosine phosphorylation, activation of Jak1 and Jak2 and phosphorylation of Stat1 was developed in phorbol 12-myristate 13-acetate-differentiated U-937 cells.
1	To	to	PART	TO	_	_	_	_	_
2	investigate	investigate	VERB	VB	VerbForm=Inf	_	_	_	_
3	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
4	mechanisms	mechanism	NOUN	NNS	Number=Plur	_	_	_	_
5	accounting	accounte	NOUN	NN	Number=Sing	_	_	_	_
6	for	for	ADP	IN	_	_	_	_	_
7	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
8	impaired	impaired	ADJ	JJ	Degree=Pos	_	_	_	_
9	responses	response	NOUN	NNS	Number=Plur	_	_	_	_
10	to	to	ADP	IN	_	_	_	_	_
11	gamma	gamma	NOUN	NN	Number=Sing	_	_	_	_
12	interferon	interferon	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
13	,	,	PUNCT	,	_	_	_	_	_
14	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
15	model	model	NOUN	NN	Number=Sing	_	_	_	_
16	system	system	NOUN	NN	Number=Sing	_	_	_	_
17	for	for	SCONJ	IN	_	_	_	_	_
18	examining	examine	VERB	VBG	VerbForm=Ger	_	_	_	_
19	overall	overall	ADJ	JJ	Degree=Pos	_	_	_	_
20	changes	change	NOUN	NNS	Number=Plur	_	_	_	_
21	in	in	ADP	IN	_	_	_	_	_
22	protein	protein	NOUN	NN	Number=Sing	_	_	_	_
23	tyrosine	tyrosine	NOUN	NN	Number=Sing	_	_	_	_
24	phosphorylation	phosphorylation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
25	,	,	PUNCT	,	_	_	_	_	_
26	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
27	of	of	ADP	IN	_	_	_	_	_
28	Jak1	Jak1	PROPN	NNP	Number=Sing	_	_	_	_
29	and	and	CCONJ	CC	_	_	_	_	_
30	Jak2	Jak2	NUM	CD	NumType=Card	_	_	_	_
31	and	and	CCONJ	CC	_	_	_	_	_
32	phosphorylation	phosphorylation	NOUN	NN	Number=Sing	_	_	_	_
33	of	of	ADP	IN	_	_	_	_	_
34	Stat1	stat1	PROPN	NNP	Number=Sing	_	_	_	_
35	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
36	developed	develop	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
37	in	in	ADP	IN	_	_	_	_	_
38	phorbol	phorbol	NOUN	NN	Number=Sing	_	_	_	_
39	12	12	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
40	-	-	PUNCT	:	_	_	_	_	SpaceAfter=No
41	myristate	myristate	NOUN	NN	Number=Sing	_	_	_	_
42	13	13	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
43	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
44	acetate	acetate	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
45	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
46	differentiated	differentiate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
47	U	U	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
48	-	-	SYM	SYM	_	_	_	_	SpaceAfter=No
49	937	937	NUM	CD	NumType=Card	_	_	_	_
50	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
51	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2652
# text = Analysis of whole-cell lysates by antiphosphotyrosine immunoblotting showed that incubation with gamma interferon brought about specific increases in phosphotyrosine labeling of several proteins.
1	Analysis	analysis	NOUN	NN	Number=Sing	_	_	_	_
2	of	of	ADP	IN	_	_	_	_	_
3	whole	whole	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
4	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
5	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
6	lysates	lysate	NOUN	NNS	Number=Plur	_	_	_	_
7	by	by	ADP	IN	_	_	_	_	_
8	antiphosphotyrosine	antiphosphotyrosine	ADJ	JJ	Degree=Pos	_	_	_	_
9	immunoblotting	immunoblott	NOUN	NN	Number=Sing	_	_	_	_
10	showed	show	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
11	that	that	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
12	incubation	incubation	NOUN	NN	Number=Sing	_	_	_	_
13	with	with	ADP	IN	_	_	_	_	_
14	gamma	gamma	NOUN	NN	Number=Sing	_	_	_	_
15	interferon	interferon	NOUN	NN	Number=Sing	_	_	_	_
16	brought	bring	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
17	about	about	ADP	IN	_	_	_	_	_
18	specific	specific	ADJ	JJ	Degree=Pos	_	_	_	_
19	increases	increase	NOUN	NNS	Number=Plur	_	_	_	_
20	in	in	ADP	IN	_	_	_	_	_
21	phosphotyrosine	phosphotyrosine	NOUN	NN	Number=Sing	_	_	_	_
22	labeling	labeling	NOUN	NN	Number=Sing	_	_	_	_
23	of	of	ADP	IN	_	_	_	_	_
24	several	several	ADJ	JJ	Degree=Pos	_	_	_	_
25	proteins	protein	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
26	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2653
# text = Increased labeling of these proteins occurred to similar extents in control cells and in cells that had been infected with L. donovani for 16 h.
1	Increased	increase	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
2	labeling	labeling	NOUN	NN	Number=Sing	_	_	_	_
3	of	of	ADP	IN	_	_	_	_	_
4	these	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
5	proteins	protein	NOUN	NNS	Number=Plur	_	_	_	_
6	occurred	occur	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
7	to	to	ADP	IN	_	_	_	_	_
8	similar	similar	ADJ	JJ	Degree=Pos	_	_	_	_
9	extents	extent	NOUN	NNS	Number=Plur	_	_	_	_
10	in	in	ADP	IN	_	_	_	_	_
11	control	control	NOUN	NN	Number=Sing	_	_	_	_
12	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
13	and	and	CCONJ	CC	_	_	_	_	_
14	in	in	ADP	IN	_	_	_	_	_
15	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
16	that	that	PRON	WDT	PronType=Rel	_	_	_	_
17	had	have	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
18	been	be	AUX	VBN	Tense=Past|VerbForm=Part	_	_	_	_
19	infected	infect	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
20	with	with	ADP	IN	_	_	_	_	_
21	L.	L.	PROPN	NNP	Number=Sing	_	_	_	_
22	donovani	donovani	PROPN	NNP	Number=Sing	_	_	_	_
23	for	for	ADP	IN	_	_	_	_	_
24	16	16	NUM	CD	NumType=Card	_	_	_	_
25	h	h	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
26	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2654
# text = Jak1, Jak2, and Stat1 were immunoprecipitated from control and interferon-treated cells, and tyrosine phosphorylation of these proteins, detected by antiphosphotyrosine immunoblotting was used to measured their activation.
1	Jak1	Jak1	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
2	,	,	PUNCT	,	_	_	_	_	_
3	Jak2	jak2	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
4	,	,	PUNCT	,	_	_	_	_	_
5	and	and	CCONJ	CC	_	_	_	_	_
6	Stat1	Stat1	PROPN	NNP	Number=Sing	_	_	_	_
7	were	be	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
8	immunoprecipitated	immunoprecipitate	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
9	from	from	ADP	IN	_	_	_	_	_
10	control	control	NOUN	NN	Number=Sing	_	_	_	_
11	and	and	CCONJ	CC	_	_	_	_	_
12	interferon	interferon	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
13	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
14	treated	treat	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
15	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
16	,	,	PUNCT	,	_	_	_	_	_
17	and	and	CCONJ	CC	_	_	_	_	_
18	tyrosine	tyrosine	NOUN	NN	Number=Sing	_	_	_	_
19	phosphorylation	phosphorylation	NOUN	NN	Number=Sing	_	_	_	_
20	of	of	ADP	IN	_	_	_	_	_
21	these	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
22	proteins	protein	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
23	,	,	PUNCT	,	_	_	_	_	_
24	detected	detect	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
25	by	by	ADP	IN	_	_	_	_	_
26	antiphosphotyrosine	antiphosphotyrosine	NOUN	NN	Number=Sing	_	_	_	_
27	immunoblotting	immunoblotting	NOUN	NN	Number=Sing	_	_	_	_
28	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
29	used	use	ADJ	JJ	Degree=Pos	_	_	_	_
30	to	to	PART	TO	_	_	_	_	_
31	measured	measure	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
32	their	they	PRON	PRP$	Number=Plur|Person=3|Poss=Yes|PronType=Prs	_	_	_	_
33	activation	activation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
34	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2655
# text = Tyrosine phosphorylation of Jak1, Jak2, and Stat1 increased markedly, in a dose-dependent manner, in U-937 cells incubated with gamma interferon.
1	Tyrosine	Tyrosine	NOUN	NN	Number=Sing	_	_	_	_
2	phosphorylation	phosphorylation	NOUN	NN	Number=Sing	_	_	_	_
3	of	of	ADP	IN	_	_	_	_	_
4	Jak1	Jak1	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
5	,	,	PUNCT	,	_	_	_	_	_
6	Jak2	jak2	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
7	,	,	PUNCT	,	_	_	_	_	_
8	and	and	CCONJ	CC	_	_	_	_	_
9	Stat1	Stat1	PROPN	NNP	Number=Sing	_	_	_	_
10	increased	increase	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
11	markedly	markedly	ADV	RB	_	_	_	_	SpaceAfter=No
12	,	,	PUNCT	,	_	_	_	_	_
13	in	in	ADP	IN	_	_	_	_	_
14	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
15	dose	dose	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
16	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
17	dependent	dependent	ADJ	JJ	Degree=Pos	_	_	_	_
18	manner	manner	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
19	,	,	PUNCT	,	_	_	_	_	_
20	in	in	ADP	IN	_	_	_	_	_
21	U	U	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
22	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
23	937	937	NUM	CD	NumType=Card	_	_	_	_
24	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
25	incubated	incubate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
26	with	with	ADP	IN	_	_	_	_	_
27	gamma	gamma	NOUN	NN	Number=Sing	_	_	_	_
28	interferon	interferon	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
29	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2656
# text = In contrast, in cells infected with L.
1	In	in	ADP	IN	_	_	_	_	_
2	contrast	contrast	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
3	,	,	PUNCT	,	_	_	_	_	_
4	in	in	ADP	IN	_	_	_	_	_
5	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
6	infected	infect	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
7	with	with	ADP	IN	_	_	_	_	_
8	L.	L.	PROPN	NNP	Number=Sing	_	_	_	_

# sent_id = 2657
# text = donovani, tyrosine phosphorylation of Jak1, Jak2, and Stat1 was markedly impaired.
1	donovani	donovani	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
2	,	,	PUNCT	,	_	_	_	_	_
3	tyrosine	tyrosine	ADJ	JJ	Degree=Pos	_	_	_	_
4	phosphorylation	phosphorylation	NOUN	NN	Number=Sing	_	_	_	_
5	of	of	ADP	IN	_	_	_	_	_
6	Jak1	Jak1	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
7	,	,	PUNCT	,	_	_	_	_	_
8	Jak2	jak2	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
9	,	,	PUNCT	,	_	_	_	_	_
10	and	and	CCONJ	CC	_	_	_	_	_
11	Stat1	Stat1	PROPN	NNP	Number=Sing	_	_	_	_
12	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
13	markedly	markedly	ADV	RB	_	_	_	_	_
14	impaired	impaired	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	SpaceAfter=No
15	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2658
# text = This effect was dependent upon the duration of exposure to L. donovani and was maximal and complete at 16 h.
1	This	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
2	effect	effect	NOUN	NN	Number=Sing	_	_	_	_
3	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
4	dependent	dependent	ADJ	JJ	Degree=Pos	_	_	_	_
5	upon	upon	ADP	IN	_	_	_	_	_
6	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
7	duration	duration	NOUN	NN	Number=Sing	_	_	_	_
8	of	of	ADP	IN	_	_	_	_	_
9	exposure	exposure	NOUN	NN	Number=Sing	_	_	_	_
10	to	to	ADP	IN	_	_	_	_	_
11	L.	L.	PROPN	NNP	Number=Sing	_	_	_	_
12	donovani	donovani	PROPN	NNP	Number=Sing	_	_	_	_
13	and	and	CCONJ	CC	_	_	_	_	_
14	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
15	maximal	maximal	ADJ	JJ	Degree=Pos	_	_	_	_
16	and	and	CCONJ	CC	_	_	_	_	_
17	complete	complete	ADJ	JJ	Degree=Pos	_	_	_	_
18	at	at	ADP	IN	_	_	_	_	_
19	16	16	NUM	CD	NumType=Card	_	_	_	_
20	h	h	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
21	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2659
# text = Results similar to those observed with U-937 cells were also obtained with human peripheral blood monocytes.
1	Results	result	NOUN	NNS	Number=Plur	_	_	_	_
2	similar	similar	ADJ	JJ	Degree=Pos	_	_	_	_
3	to	to	ADP	IN	_	_	_	_	_
4	those	those	PRON	DT	Number=Plur|PronType=Dem	_	_	_	_
5	observed	observe	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
6	with	with	ADP	IN	_	_	_	_	_
7	U	U	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
8	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
9	937	937	NUM	CD	NumType=Card	_	_	_	_
10	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
11	were	be	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
12	also	also	ADV	RB	_	_	_	_	_
13	obtained	obtain	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
14	with	with	ADP	IN	_	_	_	_	_
15	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
16	peripheral	peripheral	ADJ	JJ	Degree=Pos	_	_	_	_
17	blood	blood	NOUN	NN	Number=Sing	_	_	_	_
18	monocytes	monocyte	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
19	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2660
# text = These findings indicate that infection of human mononuclear phagocytes with L. donovani leads to impaired gamma interferon-mediated tyrosine phosphorylation and selective effects on the Jak-Stat1 pathway.
1	These	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
2	findings	finding	NOUN	NNS	Number=Plur	_	_	_	_
3	indicate	indicate	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
4	that	that	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
5	infection	infection	NOUN	NN	Number=Sing	_	_	_	_
6	of	of	ADP	IN	_	_	_	_	_
7	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
8	mononuclear	mononuclear	NOUN	NN	Number=Sing	_	_	_	_
9	phagocytes	phagocyte	NOUN	NNS	Number=Plur	_	_	_	_
10	with	with	ADP	IN	_	_	_	_	_
11	L.	L.	PROPN	NNP	Number=Sing	_	_	_	_
12	donovani	donovani	PROPN	NNP	Number=Sing	_	_	_	_
13	leads	lead	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
14	to	to	ADP	IN	_	_	_	_	_
15	impaired	impaired	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
16	gamma	gamma	NOUN	NN	Number=Sing	_	_	_	_
17	interferon	interferon	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
18	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
19	mediated	mediate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
20	tyrosine	tyrosine	NOUN	NN	Number=Sing	_	_	_	_
21	phosphorylation	phosphorylation	NOUN	NN	Number=Sing	_	_	_	_
22	and	and	CCONJ	CC	_	_	_	_	_
23	selective	selective	ADJ	JJ	Degree=Pos	_	_	_	_
24	effects	effect	NOUN	NNS	Number=Plur	_	_	_	_
25	on	on	ADP	IN	_	_	_	_	_
26	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
27	Jak	Jak	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
28	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
29	Stat1	Stat1	PROPN	NNP	Number=Sing	_	_	_	_
30	pathway	pathway	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
31	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2661
# text = Unresponsiveness to gamma interferon for activation of this pathway may explain impaired transcriptional responses in leishmania-infected cells.
1	Unresponsiveness	Unresponsiveness	NOUN	NN	Number=Sing	_	_	_	_
2	to	to	ADP	IN	_	_	_	_	_
3	gamma	gamma	NOUN	NN	Number=Sing	_	_	_	_
4	interferon	interferon	NOUN	NN	Number=Sing	_	_	_	_
5	for	for	ADP	IN	_	_	_	_	_
6	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
7	of	of	ADP	IN	_	_	_	_	_
8	this	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
9	pathway	pathway	NOUN	NN	Number=Sing	_	_	_	_
10	may	may	AUX	MD	VerbForm=Fin	_	_	_	_
11	explain	explain	VERB	VB	VerbForm=Inf	_	_	_	_
12	impaired	impaired	ADJ	JJ	Degree=Pos	_	_	_	_
13	transcriptional	transcriptional	ADJ	JJ	Degree=Pos	_	_	_	_
14	responses	response	NOUN	NNS	Number=Plur	_	_	_	_
15	in	in	ADP	IN	_	_	_	_	_
16	leishmania	leishmania	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
17	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
18	infected	infect	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
19	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
20	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 2662
# text = Document 003003287 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	003003287	003003287	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 2663
# text = Multiple proteins interact with the nuclear inhibitory protein repressor element in the human interleukin-3 promoter.
1	Multiple	multiple	ADJ	JJ	Degree=Pos	_	_	_	_
2	proteins	protein	NOUN	NNS	Number=Plur	_	_	_	_
3	interact	interact	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
4	with	with	ADP	IN	_	_	_	_	_
5	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
6	nuclear	nuclear	ADJ	JJ	Degree=Pos	_	_	_	_
7	inhibitory	inhibitory	NOUN	NN	Number=Sing	_	_	_	_
8	protein	protein	NOUN	NN	Number=Sing	_	_	_	_
9	repressor	repressor	NOUN	NN	Number=Sing	_	_	_	_
10	element	element	NOUN	NN	Number=Sing	_	_	_	_
11	in	in	ADP	IN	_	_	_	_	_
12	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
13	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
14	interleukin	interleukin	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
15	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
16	3	3	NUM	CD	NumType=Card	_	_	_	_
17	promoter	promoter	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
18	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 2664
# text = T cell expression of interleukin 3 (IL-3) is directed by positive and negative cis-acting DNA elements clustered within 300 base pairs of the transcriptional start site.
1	T	t	PROPN	NNP	Number=Sing	_	_	_	_
2	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
3	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
4	of	of	ADP	IN	_	_	_	_	_
5	interleukin	interleukin	NOUN	NN	Number=Sing	_	_	_	_
6	3	3	NUM	CD	NumType=Card	_	_	_	_
7	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
8	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
9	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
10	3	3	X	LS	_	_	_	_	SpaceAfter=No
11	)	)	PUNCT	-RRB-	_	_	_	_	_
12	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
13	directed	direct	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
14	by	by	ADP	IN	_	_	_	_	_
15	positive	positive	ADJ	JJ	Degree=Pos	_	_	_	_
16	and	and	CCONJ	CC	_	_	_	_	_
17	negative	negative	ADJ	JJ	Degree=Pos	_	_	_	_
18	cis	cis	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
19	-acting	-act	VERB	VBG	VerbForm=Ger	_	_	_	_
20	DNA	dna	NOUN	NN	Number=Sing	_	_	_	_
21	elements	element	NOUN	NNS	Number=Plur	_	_	_	_
22	clustered	cluster	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
23	within	within	ADP	IN	_	_	_	_	_
24	300	300	NUM	CD	NumType=Card	_	_	_	_
25	base	base	NOUN	NN	Number=Sing	_	_	_	_
26	pairs	pair	NOUN	NNS	Number=Plur	_	_	_	_
27	of	of	ADP	IN	_	_	_	_	_
28	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
29	transcriptional	transcriptional	ADJ	JJ	Degree=Pos	_	_	_	_
30	start	start	NOUN	NN	Number=Sing	_	_	_	_
31	site	site	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
32	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2665
# text = A strong repressor element, termed nuclear inhibitory protein (NIP), was previously mapped to a segment of the IL-3 promoter between nucleotides -271 and -250.
1	A	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
2	strong	strong	ADJ	JJ	Degree=Pos	_	_	_	_
3	repressor	repressor	NOUN	NN	Number=Sing	_	_	_	_
4	element	element	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
5	,	,	PUNCT	,	_	_	_	_	_
6	termed	term	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
7	nuclear	nuclear	ADJ	JJ	Degree=Pos	_	_	_	_
8	inhibitory	inhibitory	NOUN	NN	Number=Sing	_	_	_	_
9	protein	protein	NOUN	NN	Number=Sing	_	_	_	_
10	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
11	NIP	NIP	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
12	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
13	,	,	PUNCT	,	_	_	_	_	_
14	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
15	previously	previously	ADV	RB	_	_	_	_	_
16	mapped	map	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
17	to	to	ADP	IN	_	_	_	_	_
18	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
19	segment	segment	NOUN	NN	Number=Sing	_	_	_	_
20	of	of	ADP	IN	_	_	_	_	_
21	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
22	IL	Il	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
23	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
24	3	3	NUM	CD	NumType=Card	_	_	_	_
25	promoter	promoter	NOUN	NN	Number=Sing	_	_	_	_
26	between	between	ADP	IN	_	_	_	_	_
27	nucleotides	nucleotide	NOUN	NNS	Number=Plur	_	_	_	_
28	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
29	271	271	NUM	CD	NumType=Card	_	_	_	_
30	and	and	CCONJ	CC	_	_	_	_	_
31	-	-	SYM	SYM	_	_	_	_	SpaceAfter=No
32	250	250	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
33	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2666
# text = Functional characterization of this element demonstrates that it can mediate repression when linked in cis to a heterologous promoter.
1	Functional	functional	ADJ	JJ	Degree=Pos	_	_	_	_
2	characterization	characterization	NOUN	NN	Number=Sing	_	_	_	_
3	of	of	ADP	IN	_	_	_	_	_
4	this	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
5	element	element	NOUN	NN	Number=Sing	_	_	_	_
6	demonstrates	demonstrate	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
7	that	that	SCONJ	IN	_	_	_	_	_
8	it	it	PRON	PRP	Case=Nom|Gender=Neut|Number=Sing|Person=3|PronType=Prs	_	_	_	_
9	can	can	AUX	MD	VerbForm=Fin	_	_	_	_
10	mediate	mediate	VERB	VB	VerbForm=Inf	_	_	_	_
11	repression	repression	NOUN	NN	Number=Sing	_	_	_	_
12	when	when	ADV	WRB	PronType=Int	_	_	_	_
13	linked	link	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
14	in	in	ADP	IN	_	_	_	_	_
15	cis	cis	NOUN	NN	Number=Sing	_	_	_	_
16	to	to	ADP	IN	_	_	_	_	_
17	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
18	heterologous	heterologous	ADJ	JJ	Degree=Pos	_	_	_	_
19	promoter	promoter	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
20	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2667
# text = DNA binding experiments were carried out to characterize the repressor activity.
1	DNA	dna	NOUN	NN	Number=Sing	_	_	_	_
2	binding	binding	VERB	VBG	VerbForm=Ger	_	_	_	_
3	experiments	experiment	NOUN	NNS	Number=Plur	_	_	_	_
4	were	be	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
5	carried	carry	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
6	out	out	ADV	RB	_	_	_	_	_
7	to	to	PART	TO	_	_	_	_	_
8	characterize	characterize	VERB	VB	VerbForm=Inf	_	_	_	_
9	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
10	repressor	repressor	NOUN	NN	Number=Sing	_	_	_	_
11	activity	activity	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
12	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2668
# text = Using varying conditions, three distinct complexes were shown to interact specifically with the NIP region, although only one correlates with repressor activity.
1	Using	use	VERB	VBG	VerbForm=Ger	_	_	_	_
2	varying	varying	VERB	VBG	VerbForm=Ger	_	_	_	_
3	conditions	condition	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	,	,	PUNCT	,	_	_	_	_	_
5	three	three	NUM	CD	NumType=Card	_	_	_	_
6	distinct	distinct	ADJ	JJ	Degree=Pos	_	_	_	_
7	complexes	complexe	NOUN	NNS	Number=Plur	_	_	_	_
8	were	be	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
9	shown	show	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
10	to	to	PART	TO	_	_	_	_	_
11	interact	interact	VERB	VB	VerbForm=Inf	_	_	_	_
12	specifically	specifically	ADV	RB	_	_	_	_	_
13	with	with	ADP	IN	_	_	_	_	_
14	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
15	NIP	Nip	PROPN	NNP	Number=Sing	_	_	_	_
16	region	region	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
17	,	,	PUNCT	,	_	_	_	_	_
18	although	although	SCONJ	IN	_	_	_	_	_
19	only	only	ADV	RB	_	_	_	_	_
20	one	one	NUM	CD	NumType=Card	_	_	_	_
21	correlates	correlate	NOUN	NNS	Number=Plur	_	_	_	_
22	with	with	ADP	IN	_	_	_	_	_
23	repressor	repressor	NOUN	NN	Number=Sing	_	_	_	_
24	activity	activity	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
25	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2669
# text = Complex 1 results from binding of a ubiquitous polypeptide that recognizes the 3' portion of this sequence and is not required for repression.
1	Complex	complex	VERB	VB	Mood=Imp|VerbForm=Fin	_	_	_	_
2	1	1	NUM	CD	NumType=Card	_	_	_	_
3	results	result	NOUN	NNS	Number=Plur	_	_	_	_
4	from	from	SCONJ	IN	_	_	_	_	_
5	binding	binding	VERB	VBG	VerbForm=Ger	_	_	_	_
6	of	of	ADP	IN	_	_	_	_	_
7	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
8	ubiquitous	ubiquitous	ADJ	JJ	Degree=Pos	_	_	_	_
9	polypeptide	polypeptide	NOUN	NN	Number=Sing	_	_	_	_
10	that	that	PRON	WDT	PronType=Rel	_	_	_	_
11	recognizes	recognize	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
12	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
13	3	3	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
14	'	'	PUNCT	``	_	_	_	_	_
15	portion	portion	NOUN	NN	Number=Sing	_	_	_	_
16	of	of	ADP	IN	_	_	_	_	_
17	this	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
18	sequence	sequence	NOUN	NN	Number=Sing	_	_	_	_
19	and	and	CCONJ	CC	_	_	_	_	_
20	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
21	not	not	PART	RB	_	_	_	_	_
22	required	require	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
23	for	for	ADP	IN	_	_	_	_	_
24	repression	repression	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
25	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2670
# text = Complex 2 corresponds to binding of transcription factor (upstream stimulatory factor) to an E-box motif in the 5' portion of the NIP region.
1	Complex	complex	VERB	VB	Mood=Imp|VerbForm=Fin	_	_	_	_
2	2	2	NUM	CD	NumType=Card	_	_	_	_
3	corresponds	corresponds	NOUN	NNS	Number=Plur	_	_	_	_
4	to	to	SCONJ	IN	_	_	_	_	_
5	binding	binde	VERB	VBG	VerbForm=Ger	_	_	_	_
6	of	of	ADP	IN	_	_	_	_	_
7	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
8	factor	factor	NOUN	NN	Number=Sing	_	_	_	_
9	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
10	upstream	upstream	ADJ	JJ	Degree=Pos	_	_	_	_
11	stimulatory	stimulatory	ADJ	JJ	Degree=Pos	_	_	_	_
12	factor	factor	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
13	)	)	PUNCT	-RRB-	_	_	_	_	_
14	to	to	ADP	IN	_	_	_	_	_
15	an	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
16	E-	e-	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
17	box	box	NOUN	NN	Number=Sing	_	_	_	_
18	motif	motif	NOUN	NN	Number=Sing	_	_	_	_
19	in	in	ADP	IN	_	_	_	_	_
20	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
21	5	5	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
22	'	's	PUNCT	``	_	_	_	_	_
23	portion	portion	NOUN	NN	Number=Sing	_	_	_	_
24	of	of	ADP	IN	_	_	_	_	_
25	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
26	NIP	NIP	PROPN	NNP	Number=Sing	_	_	_	_
27	region	region	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
28	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2671
# text = DNA binding specificity of complex 3 overlaps with that of upstream stimulatory factor but is clearly distinct.
1	DNA	dna	NOUN	NN	Number=Sing	_	_	_	_
2	binding	binde	VERB	VBG	VerbForm=Ger	_	_	_	_
3	specificity	specificity	NOUN	NN	Number=Sing	_	_	_	_
4	of	of	ADP	IN	_	_	_	_	_
5	complex	complex	ADJ	JJ	Degree=Pos	_	_	_	_
6	3	3	NUM	CD	NumType=Card	_	_	_	_
7	overlaps	overlaps	NOUN	NNS	Number=Plur	_	_	_	_
8	with	with	ADP	IN	_	_	_	_	_
9	that	that	PRON	DT	Number=Sing|PronType=Dem	_	_	_	_
10	of	of	ADP	IN	_	_	_	_	_
11	upstream	upstream	ADJ	JJ	Degree=Pos	_	_	_	_
12	stimulatory	stimulatory	ADJ	JJ	Degree=Pos	_	_	_	_
13	factor	factor	NOUN	NN	Number=Sing	_	_	_	_
14	but	but	CCONJ	CC	_	_	_	_	_
15	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
16	clearly	clearly	ADV	RB	_	_	_	_	_
17	distinct	distinct	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
18	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2672
# text = To determine which of the latter two complexes represents NIP activity, we incorporated small alterations into the NIP site of an IL-3 promoter-linked reporter construct and examined their effects on NIP-mediated repression.
1	To	to	PART	TO	_	_	_	_	_
2	determine	determine	VERB	VB	VerbForm=Inf	_	_	_	_
3	which	which	PRON	WDT	PronType=Int	_	_	_	_
4	of	of	ADP	IN	_	_	_	_	_
5	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
6	latter	latter	ADJ	JJ	Degree=Pos	_	_	_	_
7	two	two	NUM	CD	NumType=Card	_	_	_	_
8	complexes	complexe	NOUN	NNS	Number=Plur	_	_	_	_
9	represents	represent	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
10	NIP	Nip	ADJ	JJ	Degree=Pos	_	_	_	_
11	activity	activity	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
12	,	,	PUNCT	,	_	_	_	_	_
13	we	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
14	incorporated	incorporate	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
15	small	small	ADJ	JJ	Degree=Pos	_	_	_	_
16	alterations	alteration	NOUN	NNS	Number=Plur	_	_	_	_
17	into	into	ADP	IN	_	_	_	_	_
18	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
19	NIP	NIP	PROPN	NNP	Number=Sing	_	_	_	_
20	site	site	NOUN	NN	Number=Sing	_	_	_	_
21	of	of	ADP	IN	_	_	_	_	_
22	an	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
23	IL	IL	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
24	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
25	3	3	NUM	CD	NumType=Card	_	_	_	_
26	promoter	promoter	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
27	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
28	linked	link	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
29	reporter	reporter	NOUN	NN	Number=Sing	_	_	_	_
30	construct	construct	NOUN	NN	Number=Sing	_	_	_	_
31	and	and	CCONJ	CC	_	_	_	_	_
32	examined	examin	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
33	their	they	PRON	PRP$	Number=Plur|Person=3|Poss=Yes|PronType=Prs	_	_	_	_
34	effects	effect	NOUN	NNS	Number=Plur	_	_	_	_
35	on	on	ADP	IN	_	_	_	_	_
36	NIP-	NIP-	SYM	NFP	_	_	_	_	SpaceAfter=No
37	mediated	mediate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
38	repression	repression	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
39	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2673
# text = Functional specificity for repression matches the DNA binding specificity of complex 3; both repressor activity and complex 3 binding require the consensus sequence CTCACNTNC.
1	Functional	functional	ADJ	JJ	Degree=Pos	_	_	_	_
2	specificity	specificity	NOUN	NN	Number=Sing	_	_	_	_
3	for	for	ADP	IN	_	_	_	_	_
4	repression	repression	NOUN	NN	Number=Sing	_	_	_	_
5	matches	match	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
6	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
7	DNA	dna	NOUN	NN	Number=Sing	_	_	_	_
8	binding	binde	VERB	VBG	VerbForm=Ger	_	_	_	_
9	specificity	specificity	NOUN	NN	Number=Sing	_	_	_	_
10	of	of	ADP	IN	_	_	_	_	_
11	complex	complex	NOUN	NN	Number=Sing	_	_	_	_
12	3	3	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
13	;	;	PUNCT	,	_	_	_	_	_
14	both	both	CCONJ	CC	_	_	_	_	_
15	repressor	repressor	NOUN	NN	Number=Sing	_	_	_	_
16	activity	activity	NOUN	NN	Number=Sing	_	_	_	_
17	and	and	CCONJ	CC	_	_	_	_	_
18	complex	complex	NOUN	NN	Number=Sing	_	_	_	_
19	3	3	NUM	CD	NumType=Card	_	_	_	_
20	binding	bind	VERB	VBG	VerbForm=Ger	_	_	_	_
21	require	require	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
22	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
23	consensus	consensus	NOUN	NN	Number=Sing	_	_	_	_
24	sequence	sequence	NOUN	NN	Number=Sing	_	_	_	_
25	CTCACNTNC	Ctcacntnc	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
26	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 2674
# text = Document 003003292 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	003003292	003003292	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 2675
# text = Interleukin 12 induces tyrosine phosphorylation and activation of STAT4 in human lymphocytes.
1	Interleukin	Interleukin	PROPN	NNP	Number=Sing	_	_	_	_
2	12	12	NUM	CD	NumType=Card	_	_	_	_
3	induces	induce	NOUN	NNS	Number=Plur	_	_	_	_
4	tyrosine	tyrosine	NOUN	NN	Number=Sing	_	_	_	_
5	phosphorylation	phosphorylation	NOUN	NN	Number=Sing	_	_	_	_
6	and	and	CCONJ	CC	_	_	_	_	_
7	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
8	of	of	ADP	IN	_	_	_	_	_
9	STAT4	Stat4	NUM	CD	NumType=Card	_	_	_	_
10	in	in	ADP	IN	_	_	_	_	_
11	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
12	lymphocytes	lymphocyte	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
13	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 2676
# text = Interleukin 12 (IL-12) is an important immunoregulatory cytokine whose receptor is a member of the hematopoietin receptor superfamily.
1	Interleukin	Interleukin	PROPN	NNP	Number=Sing	_	_	_	_
2	12	12	NUM	CD	NumType=Card	_	_	_	_
3	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
4	IL	Il	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
5	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
6	12	12	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
7	)	)	PUNCT	-RRB-	_	_	_	_	_
8	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
9	an	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
10	important	important	ADJ	JJ	Degree=Pos	_	_	_	_
11	immunoregulatory	immunoregulatory	ADJ	JJ	Degree=Pos	_	_	_	_
12	cytokine	cytokine	NOUN	NN	Number=Sing	_	_	_	_
13	whose	whose	PRON	WP$	Poss=Yes|PronType=Int	_	_	_	_
14	receptor	receptor	NOUN	NN	Number=Sing	_	_	_	_
15	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
16	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
17	member	member	NOUN	NN	Number=Sing	_	_	_	_
18	of	of	ADP	IN	_	_	_	_	_
19	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
20	hematopoietin	hematopoietin	NOUN	NN	Number=Sing	_	_	_	_
21	receptor	receptor	NOUN	NN	Number=Sing	_	_	_	_
22	superfamily	superfamily	ADV	RB	_	_	_	_	SpaceAfter=No
23	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2677
# text = We have recently demonstrated that stimulation of human T and natural killer cells with IL-12 induces tyrosine phosphorylation of the Janus family tyrosine kinase JAK2 and Tyk2, implicating these kinases in the immediate biochemical response to IL-12.
1	We	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
2	have	have	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
3	recently	recently	ADV	RB	_	_	_	_	_
4	demonstrated	demonstrate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
5	that	that	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
6	stimulation	stimulation	NOUN	NN	Number=Sing	_	_	_	_
7	of	of	ADP	IN	_	_	_	_	_
8	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
9	T	T	PROPN	NNP	Number=Sing	_	_	_	_
10	and	and	CCONJ	CC	_	_	_	_	_
11	natural	natural	ADJ	JJ	Degree=Pos	_	_	_	_
12	killer	killer	NOUN	NN	Number=Sing	_	_	_	_
13	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
14	with	with	ADP	IN	_	_	_	_	_
15	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
16	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
17	12	12	NUM	CD	NumType=Card	_	_	_	_
18	induces	induces	NOUN	NNS	Number=Plur	_	_	_	_
19	tyrosine	tyrosine	NOUN	NN	Number=Sing	_	_	_	_
20	phosphorylation	phosphorylation	NOUN	NN	Number=Sing	_	_	_	_
21	of	of	ADP	IN	_	_	_	_	_
22	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
23	Janus	Janus	PROPN	NNP	Number=Sing	_	_	_	_
24	family	family	NOUN	NN	Number=Sing	_	_	_	_
25	tyrosine	tyrosine	NOUN	NN	Number=Sing	_	_	_	_
26	kinase	kinase	NOUN	NN	Number=Sing	_	_	_	_
27	JAK2	Jak2	NOUN	NN	Number=Sing	_	_	_	_
28	and	and	CCONJ	CC	_	_	_	_	_
29	Tyk2	tyk2	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
30	,	,	PUNCT	,	_	_	_	_	_
31	implicating	implicate	VERB	VBG	VerbForm=Ger	_	_	_	_
32	these	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
33	kinases	kinase	NOUN	NNS	Number=Plur	_	_	_	_
34	in	in	ADP	IN	_	_	_	_	_
35	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
36	immediate	immediate	ADJ	JJ	Degree=Pos	_	_	_	_
37	biochemical	biochemical	ADJ	JJ	Degree=Pos	_	_	_	_
38	response	response	NOUN	NN	Number=Sing	_	_	_	_
39	to	to	ADP	IN	_	_	_	_	_
40	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
41	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
42	12	12	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
43	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2678
# text = Recently, transcription factors known as STATs (signal transducers and activators of transcription) have been shown to be tyrosine phosphorylated and activated in response to a number of cytokines that bind hematopoietin receptors and activate JAK kinases.
1	Recently	recently	ADV	RB	_	_	_	_	SpaceAfter=No
2	,	,	PUNCT	,	_	_	_	_	_
3	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
4	factors	factor	NOUN	NNS	Number=Plur	_	_	_	_
5	known	know	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
6	as	as	ADP	IN	_	_	_	_	_
7	STATs	STATs	PROPN	NNP	Number=Sing	_	_	_	_
8	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
9	signal	signal	NOUN	NN	Number=Sing	_	_	_	_
10	transducers	transducer	NOUN	NNS	Number=Plur	_	_	_	_
11	and	and	CCONJ	CC	_	_	_	_	_
12	activators	activator	NOUN	NNS	Number=Plur	_	_	_	_
13	of	of	ADP	IN	_	_	_	_	_
14	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
15	)	)	PUNCT	-RRB-	_	_	_	_	_
16	have	have	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
17	been	be	AUX	VBN	Tense=Past|VerbForm=Part	_	_	_	_
18	shown	show	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
19	to	to	PART	TO	_	_	_	_	_
20	be	be	AUX	VB	VerbForm=Inf	_	_	_	_
21	tyrosine	tyrosine	PRON	PRP	_	_	_	_	_
22	phosphorylated	phosphorylate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
23	and	and	CCONJ	CC	_	_	_	_	_
24	activated	activate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
25	in	in	ADP	IN	_	_	_	_	_
26	response	response	NOUN	NN	Number=Sing	_	_	_	_
27	to	to	ADP	IN	_	_	_	_	_
28	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
29	number	number	NOUN	NN	Number=Sing	_	_	_	_
30	of	of	ADP	IN	_	_	_	_	_
31	cytokines	cytokine	NOUN	NNS	Number=Plur	_	_	_	_
32	that	that	PRON	WDT	PronType=Rel	_	_	_	_
33	bind	bind	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
34	hematopoietin	hematopoietin	ADJ	JJ	Degree=Pos	_	_	_	_
35	receptors	receptor	NOUN	NNS	Number=Plur	_	_	_	_
36	and	and	CCONJ	CC	_	_	_	_	_
37	activate	activate	ADJ	JJ	Degree=Pos	_	_	_	_
38	JAK	JAK	PROPN	NNP	Number=Sing	_	_	_	_
39	kinases	kinase	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
40	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2679
# text = In this report we demonstrate that IL-12 induces tyrosine phosphorylation of a recently identified
1	In	in	ADP	IN	_	_	_	_	_
2	this	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
3	report	report	NOUN	NN	Number=Sing	_	_	_	_
4	we	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
5	demonstrate	demonstrate	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
6	that	that	SCONJ	IN	_	_	_	_	_
7	IL	Il	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
8	-	-	SYM	SYM	_	_	_	_	SpaceAfter=No
9	12	12	NUM	CD	NumType=Card	_	_	_	_
10	induces	induce	NOUN	NNS	Number=Plur	_	_	_	_
11	tyrosine	tyrosine	NOUN	NN	Number=Sing	_	_	_	_
12	phosphorylation	phosphorylation	NOUN	NN	Number=Sing	_	_	_	_
13	of	of	ADP	IN	_	_	_	_	_
14	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
15	recently	recently	ADV	RB	_	_	_	_	_
16	identified	identify	ADJ	JJ	Degree=Pos	_	_	_	_

# sent_id = 2680
# text = STAT family member, STAT4, and show that STAT4 expression is regulated by T-cell activation.
1	STAT	Stat	ADJ	JJ	Degree=Pos	_	_	_	_
2	family	family	NOUN	NN	Number=Sing	_	_	_	_
3	member	member	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
4	,	,	PUNCT	,	_	_	_	_	_
5	STAT4	STAT4	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
6	,	,	PUNCT	,	_	_	_	_	_
7	and	and	CCONJ	CC	_	_	_	_	_
8	show	show	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
9	that	that	SCONJ	IN	_	_	_	_	_
10	STAT4	STAT4	NUM	CD	NumType=Card	_	_	_	_
11	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
12	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
13	regulated	regulate	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
14	by	by	ADP	IN	_	_	_	_	_
15	T-	t-	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
16	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
17	activation	activation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
18	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2681
# text = Furthermore, we show that IL-12 stimulates formation of a DNA-binding complex that recognizes a DNA sequence previously shown to bind STAT proteins and that this complex contains STAT4.
1	Furthermore	furthermore	ADV	RB	_	_	_	_	SpaceAfter=No
2	,	,	PUNCT	,	_	_	_	_	_
3	we	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
4	show	show	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
5	that	that	SCONJ	IN	_	_	_	_	_
6	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
7	-	-	SYM	SYM	_	_	_	_	SpaceAfter=No
8	12	12	NUM	CD	NumType=Card	_	_	_	_
9	stimulates	stimulate	NOUN	NNS	Number=Plur	_	_	_	_
10	formation	formation	NOUN	NN	Number=Sing	_	_	_	_
11	of	of	ADP	IN	_	_	_	_	_
12	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
13	DNA	dna	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
14	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
15	binding	binding	VERB	VBG	VerbForm=Ger	_	_	_	_
16	complex	complex	NOUN	NN	Number=Sing	_	_	_	_
17	that	that	PRON	WDT	PronType=Rel	_	_	_	_
18	recognizes	recognize	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
19	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
20	DNA	dna	NOUN	NN	Number=Sing	_	_	_	_
21	sequence	sequence	NOUN	NN	Number=Sing	_	_	_	_
22	previously	previously	ADV	RB	_	_	_	_	_
23	shown	show	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
24	to	to	PART	TO	_	_	_	_	_
25	bind	bind	VERB	VB	VerbForm=Inf	_	_	_	_
26	STAT	Stat	NOUN	NN	Number=Sing	_	_	_	_
27	proteins	protein	NOUN	NNS	Number=Plur	_	_	_	_
28	and	and	CCONJ	CC	_	_	_	_	_
29	that	that	SCONJ	IN	_	_	_	_	_
30	this	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
31	complex	complex	NOUN	NN	Number=Sing	_	_	_	_
32	contains	contain	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
33	STAT4	STAT4	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
34	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2682
# text = These data, and the recent demonstration of JAK phosphorylation by IL-12, identify a rapid signal-transduction pathway likely to mediate IL-12-induced gene expression.
1	These	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
2	data	data	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
3	,	,	PUNCT	,	_	_	_	_	_
4	and	and	CCONJ	CC	_	_	_	_	_
5	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
6	recent	recent	ADJ	JJ	Degree=Pos	_	_	_	_
7	demonstration	demonstration	NOUN	NN	Number=Sing	_	_	_	_
8	of	of	ADP	IN	_	_	_	_	_
9	JAK	JAK	PROPN	NNP	Number=Sing	_	_	_	_
10	phosphorylation	phosphorylation	NOUN	NN	Number=Sing	_	_	_	_
11	by	by	ADP	IN	_	_	_	_	_
12	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
13	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
14	12	12	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
15	,	,	PUNCT	,	_	_	_	_	_
16	identify	identify	VERB	VB	Mood=Imp|VerbForm=Fin	_	_	_	_
17	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
18	rapid	rapid	ADJ	JJ	Degree=Pos	_	_	_	_
19	signal	signal	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
20	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
21	transduction	transduction	NOUN	NN	Number=Sing	_	_	_	_
22	pathway	pathway	NOUN	NN	Number=Sing	_	_	_	_
23	likely	likely	ADV	RB	_	_	_	_	_
24	to	to	PART	TO	_	_	_	_	_
25	mediate	mediate	VERB	VB	VerbForm=Inf	_	_	_	_
26	IL	Il	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
27	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
28	12	12	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
29	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
30	induced	induce	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
31	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
32	expression	expression	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
33	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 2683
# text = Document 003003295 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	003003295	003003295	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 2684
# text = Heterogeneous expression of Epstein-Barr virus latent proteins in endemic Burkitt's lymphoma.
1	Heterogeneous	Heterogeneous	ADJ	JJ	Degree=Pos	_	_	_	_
2	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
3	of	of	ADP	IN	_	_	_	_	_
4	Epstein	Epstein	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
5	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
6	Barr	Barr	PROPN	NNP	Number=Sing	_	_	_	_
7	virus	virus	NOUN	NN	Number=Sing	_	_	_	_
8	latent	latent	ADJ	JJ	Degree=Pos	_	_	_	_
9	proteins	protein	NOUN	NNS	Number=Plur	_	_	_	_
10	in	in	ADP	IN	_	_	_	_	_
11	endemic	endemic	ADJ	JJ	Degree=Pos	_	_	_	_
12	Burkitt	Burkitt	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
13	's	's	PART	POS	_	_	_	_	_
14	lymphoma	lymphoma	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
15	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 2685
# text = Epstein-Barr virus (EBV)-infected cells may sustain three distinct forms of virus latency.
1	Epstein	Epstein	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
2	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
3	Barr	Barr	PROPN	NNP	Number=Sing	_	_	_	_
4	virus	virus	NOUN	NN	Number=Sing	_	_	_	_
5	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
6	EBV	EBV	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
7	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
8	-	-	PUNCT	:	_	_	_	_	SpaceAfter=No
9	infected	infect	ADJ	JJ	Degree=Pos	_	_	_	_
10	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
11	may	may	AUX	MD	VerbForm=Fin	_	_	_	_
12	sustain	sustain	VERB	VB	VerbForm=Inf	_	_	_	_
13	three	three	NUM	CD	NumType=Card	_	_	_	_
14	distinct	distinct	ADJ	JJ	Degree=Pos	_	_	_	_
15	forms	form	NOUN	NNS	Number=Plur	_	_	_	_
16	of	of	ADP	IN	_	_	_	_	_
17	virus	virus	NOUN	NN	Number=Sing	_	_	_	_
18	latency	latency	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
19	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2686
# text = In lymphoblastoid cell lines, six EBV-encoded nuclear antigens (EBNA1, 2, 3A, 3B, 3C, -LP), three latent membrane proteins (LMP1, 2A, 2B), and two nuclear RNAs (EBERs) are expressed.
1	In	in	ADP	IN	_	_	_	_	_
2	lymphoblastoid	lymphoblastoid	ADJ	JJ	Degree=Pos	_	_	_	_
3	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
4	lines	line	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
5	,	,	PUNCT	,	_	_	_	_	_
6	six	six	NUM	CD	NumType=Card	_	_	_	_
7	EBV	EBV	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
8	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
9	encoded	encode	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
10	nuclear	nuclear	ADJ	JJ	Degree=Pos	_	_	_	_
11	antigens	antigen	NOUN	NNS	Number=Plur	_	_	_	_
12	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
13	EBNA1	EBNA1	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
14	,	,	PUNCT	,	_	_	_	_	_
15	2	2	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
16	,	,	PUNCT	,	_	_	_	_	_
17	3A	3a	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
18	,	,	PUNCT	,	_	_	_	_	_
19	3B	3B	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
20	,	,	PUNCT	,	_	_	_	_	_
21	3C	3C	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
22	,	,	PUNCT	,	_	_	_	_	_
23	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
24	LP	Lp	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
25	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
26	,	,	PUNCT	,	_	_	_	_	_
27	three	three	NUM	CD	NumType=Card	_	_	_	_
28	latent	latent	ADJ	JJ	Degree=Pos	_	_	_	_
29	membrane	membrane	NOUN	NN	Number=Sing	_	_	_	_
30	proteins	protein	NOUN	NNS	Number=Plur	_	_	_	_
31	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
32	LMP1	LMP1	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
33	,	,	PUNCT	,	_	_	_	_	_
34	2A	2a	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
35	,	,	PUNCT	,	_	_	_	_	_
36	2B	2B	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
37	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
38	,	,	PUNCT	,	_	_	_	_	_
39	and	and	CCONJ	CC	_	_	_	_	_
40	two	two	NUM	CD	NumType=Card	_	_	_	_
41	nuclear	nuclear	ADJ	JJ	Degree=Pos	_	_	_	_
42	RNAs	RNAs	PROPN	NNPS	Number=Plur	_	_	_	_
43	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
44	EBERs	EBERs	PROPN	NNPS	Number=Plur	_	_	_	SpaceAfter=No
45	)	)	PUNCT	-RRB-	_	_	_	_	_
46	are	be	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
47	expressed	expressed	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
48	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2687
# text = This form of latency, termed latency III, is also encountered in some posttransplant lymphoproliferative disorders.
1	This	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
2	form	form	NOUN	NN	Number=Sing	_	_	_	_
3	of	of	ADP	IN	_	_	_	_	_
4	latency	latency	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
5	,	,	PUNCT	,	_	_	_	_	_
6	termed	term	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
7	latency	latency	NOUN	NN	Number=Sing	_	_	_	_
8	III	iii	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
9	,	,	PUNCT	,	_	_	_	_	_
10	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
11	also	also	ADV	RB	_	_	_	_	_
12	encountered	encounter	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
13	in	in	ADP	IN	_	_	_	_	_
14	some	some	DET	DT	_	_	_	_	_
15	posttransplant	posttransplant	ADJ	JJ	Degree=Pos	_	_	_	_
16	lymphoproliferative	lymphoproliferative	ADJ	JJ	Degree=Pos	_	_	_	_
17	disorders	disorder	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
18	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2688
# text = In EBV-positive cases of Hodgkin's disease, the EBERs, EBNA1, and the LMPs are expressed (latency II), whereas in Burkitt's lymphoma (BL) only the EBERs and EBNA1 have been detected (latency I).
1	In	in	ADP	IN	_	_	_	_	_
2	EBV	EBV	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
3	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
4	positive	positive	ADJ	JJ	Degree=Pos	_	_	_	_
5	cases	case	NOUN	NNS	Number=Plur	_	_	_	_
6	of	of	ADP	IN	_	_	_	_	_
7	Hodgkin	Hodgkin	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
8	's	's	PART	POS	_	_	_	_	_
9	disease	disease	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
10	,	,	PUNCT	,	_	_	_	_	_
11	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
12	EBERs	EBERs	PROPN	NNPS	Number=Plur	_	_	_	SpaceAfter=No
13	,	,	PUNCT	,	_	_	_	_	_
14	EBNA1	EBNA1	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
15	,	,	PUNCT	,	_	_	_	_	_
16	and	and	CCONJ	CC	_	_	_	_	_
17	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
18	LMPs	LMP	NOUN	NNS	Number=Plur	_	_	_	_
19	are	be	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
20	expressed	expressed	ADJ	JJ	Degree=Pos	_	_	_	_
21	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
22	latency	latency	NOUN	NN	Number=Sing	_	_	_	_
23	II	ii	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
24	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
25	,	,	PUNCT	,	_	_	_	_	_
26	whereas	wherea	ADV	RB	_	_	_	_	_
27	in	in	ADP	IN	_	_	_	_	_
28	Burkitt	Burkitt	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
29	's	's	PART	POS	_	_	_	_	_
30	lymphoma	lymphoma	NOUN	NN	Number=Sing	_	_	_	_
31	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
32	BL	BL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
33	)	)	PUNCT	-RRB-	_	_	_	_	_
34	only	only	ADV	RB	_	_	_	_	_
35	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
36	EBERs	EBERs	PROPN	NNPS	Number=Plur	_	_	_	_
37	and	and	CCONJ	CC	_	_	_	_	_
38	EBNA1	EBNA1	PROPN	NNP	Number=Sing	_	_	_	_
39	have	have	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
40	been	be	AUX	VBN	Tense=Past|VerbForm=Part	_	_	_	_
41	detected	detect	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
42	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
43	latency	latency	INTJ	UH	_	_	_	_	_
44	I	I	PRON	PRP	Case=Nom|Number=Sing|Person=1|PronType=Prs	_	_	_	SpaceAfter=No
45	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
46	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2689
# text = We have studied the expression of EBV proteins in 17 cases of EBV-positive endemic BL by immunohistology.
1	We	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
2	have	have	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
3	studied	studie	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
4	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
5	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
6	of	of	ADP	IN	_	_	_	_	_
7	EBV	EBV	PROPN	NNP	Number=Sing	_	_	_	_
8	proteins	protein	NOUN	NNS	Number=Plur	_	_	_	_
9	in	in	ADP	IN	_	_	_	_	_
10	17	17	NUM	CD	NumType=Card	_	_	_	_
11	cases	cas	NOUN	NNS	Number=Plur	_	_	_	_
12	of	of	ADP	IN	_	_	_	_	_
13	EBV	EBV	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
14	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
15	positive	positive	ADJ	JJ	Degree=Pos	_	_	_	_
16	endemic	endemic	ADJ	JJ	Degree=Pos	_	_	_	_
17	BL	Bl	NOUN	NN	Number=Sing	_	_	_	_
18	by	by	ADP	IN	_	_	_	_	_
19	immunohistology	immunohistology	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
20	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2690
# text = Expression of LMP1 was seen in variable proportions of tumor cells in two cases and EBNA2 was detected in some tumor cells in three other cases.
1	Expression	expression	NOUN	NN	Number=Sing	_	_	_	_
2	of	of	ADP	IN	_	_	_	_	_
3	LMP1	LMP1	PROPN	NNP	Number=Sing	_	_	_	_
4	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
5	seen	see	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
6	in	in	ADP	IN	_	_	_	_	_
7	variable	variable	ADJ	JJ	Degree=Pos	_	_	_	_
8	proportions	proportion	NOUN	NNS	Number=Plur	_	_	_	_
9	of	of	ADP	IN	_	_	_	_	_
10	tumor	tumor	NOUN	NN	Number=Sing	_	_	_	_
11	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
12	in	in	ADP	IN	_	_	_	_	_
13	two	two	NUM	CD	NumType=Card	_	_	_	_
14	cases	case	NOUN	NNS	Number=Plur	_	_	_	_
15	and	and	CCONJ	CC	_	_	_	_	_
16	EBNA2	Ebna2	NOUN	NN	Number=Sing	_	_	_	_
17	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
18	detected	detect	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
19	in	in	ADP	IN	_	_	_	_	_
20	some	some	DET	DT	_	_	_	_	_
21	tumor	tumor	NOUN	NN	Number=Sing	_	_	_	_
22	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
23	in	in	ADP	IN	_	_	_	_	_
24	three	three	NUM	CD	NumType=Card	_	_	_	_
25	other	other	ADJ	JJ	Degree=Pos	_	_	_	_
26	cases	case	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
27	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2691
# text = Also, the BZLF1 trans-activator protein was expressed in a few tumor cells in 6 cases, indicating entry into the lytic cycle.
1	Also	also	ADV	RB	_	_	_	_	SpaceAfter=No
2	,	,	PUNCT	,	_	_	_	_	_
3	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
4	BZLF1	Bzlf1	NOUN	NN	Number=Sing	_	_	_	_
5	trans-	trans-	PUNCT	,	_	_	_	_	SpaceAfter=No
6	activator	activator	NOUN	NN	Number=Sing	_	_	_	_
7	protein	protein	NOUN	NN	Number=Sing	_	_	_	_
8	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
9	expressed	express	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
10	in	in	ADP	IN	_	_	_	_	_
11	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
12	few	few	ADJ	JJ	Degree=Pos	_	_	_	_
13	tumor	tumor	NOUN	NN	Number=Sing	_	_	_	_
14	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
15	in	in	ADP	IN	_	_	_	_	_
16	6	6	NUM	CD	NumType=Card	_	_	_	_
17	cases	case	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
18	,	,	PUNCT	,	_	_	_	_	_
19	indicating	indicate	VERB	VBG	VerbForm=Ger	_	_	_	_
20	entry	entry	NOUN	NN	Number=Sing	_	_	_	_
21	into	into	ADP	IN	_	_	_	_	_
22	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
23	lytic	lytic	ADJ	JJ	Degree=Pos	_	_	_	_
24	cycle	cycle	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
25	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2692
# text = A phenotypic drift from latency I to latency III has been observed previously in some BL cell lines.
1	A	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
2	phenotypic	phenotypic	ADJ	JJ	Degree=Pos	_	_	_	_
3	drift	drift	NOUN	NN	Number=Sing	_	_	_	_
4	from	from	ADP	IN	_	_	_	_	_
5	latency	latency	NOUN	NN	Number=Sing	_	_	_	_
6	I	I	PRON	PRP	Case=Nom|Number=Sing|Person=1|PronType=Prs	_	_	_	_
7	to	to	PART	TO	_	_	_	_	_
8	latency	latency	VERB	VB	VerbForm=Inf	_	_	_	_
9	III	III	PRON	PRP	Case=Nom|Number=Sing|Person=1|PronType=Prs	_	_	_	_
10	has	have	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
11	been	be	AUX	VBN	Tense=Past|VerbForm=Part	_	_	_	_
12	observed	observe	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
13	previously	previously	ADV	RB	_	_	_	_	_
14	in	in	ADP	IN	_	_	_	_	_
15	some	some	DET	DT	_	_	_	_	_
16	BL	Bl	ADJ	JJ	Degree=Pos	_	_	_	_
17	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
18	lines	line	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
19	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2693
# text = Our results suggest that a similar phenomenon may occur in BL in vivo and indicate that the operational definition of EBV latencies is not easily applied to human tumors.
1	Our	we	PRON	PRP$	Number=Plur|Person=1|Poss=Yes|PronType=Prs	_	_	_	_
2	results	result	NOUN	NNS	Number=Plur	_	_	_	_
3	suggest	suggest	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
4	that	that	SCONJ	IN	_	_	_	_	_
5	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
6	similar	similar	ADJ	JJ	Degree=Pos	_	_	_	_
7	phenomenon	phenomenon	NOUN	NN	Number=Sing	_	_	_	_
8	may	may	AUX	MD	VerbForm=Fin	_	_	_	_
9	occur	occur	VERB	VB	VerbForm=Inf	_	_	_	_
10	in	in	ADP	IN	_	_	_	_	_
11	BL	BL	PROPN	NNP	Number=Sing	_	_	_	_
12	in	in	ADP	IN	_	_	_	_	_
13	vivo	vivo	NOUN	NN	Number=Sing	_	_	_	_
14	and	and	CCONJ	CC	_	_	_	_	_
15	indicate	indicate	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
16	that	that	SCONJ	IN	_	_	_	_	_
17	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
18	operational	operational	ADJ	JJ	Degree=Pos	_	_	_	_
19	definition	definition	NOUN	NN	Number=Sing	_	_	_	_
20	of	of	ADP	IN	_	_	_	_	_
21	EBV	EBV	PROPN	NNP	Number=Sing	_	_	_	_
22	latencies	latency	NOUN	NNS	Number=Plur	_	_	_	_
23	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
24	not	not	PART	RB	_	_	_	_	_
25	easily	easily	ADV	RB	_	_	_	_	_
26	applied	apply	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
27	to	to	ADP	IN	_	_	_	_	_
28	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
29	tumors	tumor	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
30	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 2694
# text = Document 003003298 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	003003298	003003298	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 2695
# text = Expression of erythroid-specific genes in acute megakaryoblastic leukaemia and transient myeloproliferative disorder in Down's syndrome.
1	Expression	expression	NOUN	NN	Number=Sing	_	_	_	_
2	of	of	ADP	IN	_	_	_	_	_
3	erythroid	erythroid	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
4	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
5	specific	specific	ADJ	JJ	Degree=Pos	_	_	_	_
6	genes	gene	NOUN	NNS	Number=Plur	_	_	_	_
7	in	in	ADP	IN	_	_	_	_	_
8	acute	acute	ADJ	JJ	Degree=Pos	_	_	_	_
9	megakaryoblastic	megakaryoblastic	ADJ	JJ	Degree=Pos	_	_	_	_
10	leukaemia	leukaemia	NOUN	NN	Number=Sing	_	_	_	_
11	and	and	CCONJ	CC	_	_	_	_	_
12	transient	transient	ADJ	JJ	Degree=Pos	_	_	_	_
13	myeloproliferative	myeloproliferative	ADJ	JJ	Degree=Pos	_	_	_	_
14	disorder	disorder	NOUN	NN	Number=Sing	_	_	_	_
15	in	in	ADP	IN	_	_	_	_	_
16	Down	Down	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
17	's	's	PART	POS	_	_	_	_	_
18	syndrome	syndrome	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
19	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 2696
# text = Acute megakaryoblastic leukaemia (M7) and transient myeloproliferative disorder in Down's syndrome (TMD) are characterized by rapid growth of abnormal blast cells which express megakaryocytic markers.
1	Acute	Acute	ADV	RB	_	_	_	_	_
2	megakaryoblastic	megakaryoblastic	ADJ	JJ	Degree=Pos	_	_	_	_
3	leukaemia	leukaemia	NOUN	NN	Number=Sing	_	_	_	_
4	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
5	M7	M7	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
6	)	)	PUNCT	-RRB-	_	_	_	_	_
7	and	and	CCONJ	CC	_	_	_	_	_
8	transient	transient	ADJ	JJ	Degree=Pos	_	_	_	_
9	myeloproliferative	myeloproliferative	ADJ	JJ	Degree=Pos	_	_	_	_
10	disorder	disorder	NOUN	NN	Number=Sing	_	_	_	_
11	in	in	ADP	IN	_	_	_	_	_
12	Down	Down	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
13	's	's	PART	POS	_	_	_	_	_
14	syndrome	syndrome	NOUN	NN	Number=Sing	_	_	_	_
15	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
16	TMD	tMd	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
17	)	)	PUNCT	-RRB-	_	_	_	_	_
18	are	be	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
19	characterized	characterize	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
20	by	by	ADP	IN	_	_	_	_	_
21	rapid	rapid	ADJ	JJ	Degree=Pos	_	_	_	_
22	growth	growth	NOUN	NN	Number=Sing	_	_	_	_
23	of	of	ADP	IN	_	_	_	_	_
24	abnormal	abnormal	ADJ	JJ	Degree=Pos	_	_	_	_
25	blast	blast	ADJ	JJ	Degree=Pos	_	_	_	_
26	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
27	which	which	PRON	WDT	PronType=Rel	_	_	_	_
28	express	express	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
29	megakaryocytic	megakaryocytic	ADJ	JJ	Degree=Pos	_	_	_	_
30	markers	marker	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
31	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2697
# text = To clarify properties of the blast cells in M7 and TMD cases, we examined erythroid markers expression in blasts from six cases with M7 and seven cases with TMD in this study.
1	To	to	PART	TO	_	_	_	_	_
2	clarify	clarify	VERB	VB	VerbForm=Inf	_	_	_	_
3	properties	property	NOUN	NNS	Number=Plur	_	_	_	_
4	of	of	ADP	IN	_	_	_	_	_
5	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
6	blast	blast	ADJ	JJ	Degree=Pos	_	_	_	_
7	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
8	in	in	ADP	IN	_	_	_	_	_
9	M7	M7	NOUN	NN	Number=Sing	_	_	_	_
10	and	and	CCONJ	CC	_	_	_	_	_
11	TMD	tMd	NOUN	NN	Number=Sing	_	_	_	_
12	cases	case	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
13	,	,	PUNCT	,	_	_	_	_	_
14	we	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
15	examined	examin	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
16	erythroid	erythroid	ADJ	JJ	Degree=Pos	_	_	_	_
17	markers	marker	NOUN	NNS	Number=Plur	_	_	_	_
18	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
19	in	in	ADP	IN	_	_	_	_	_
20	blasts	blast	NOUN	NNS	Number=Plur	_	_	_	_
21	from	from	ADP	IN	_	_	_	_	_
22	six	six	NUM	CD	NumType=Card	_	_	_	_
23	cases	case	NOUN	NNS	Number=Plur	_	_	_	_
24	with	with	ADP	IN	_	_	_	_	_
25	M7	M7	NUM	CD	NumType=Card	_	_	_	_
26	and	and	CCONJ	CC	_	_	_	_	_
27	seven	seven	NUM	CD	NumType=Card	_	_	_	_
28	cases	casis	NOUN	NNS	Number=Plur	_	_	_	_
29	with	with	ADP	IN	_	_	_	_	_
30	TMD	tMd	NOUN	NN	Number=Sing	_	_	_	_
31	in	in	ADP	IN	_	_	_	_	_
32	this	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
33	study	study	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
34	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2698
# text = Erythroid-specific mRNAs encoding gamma-globin and erythroid delta-aminolevulinate synthase were found to be expressed in blasts from most of these cases, indicating that majorities of the blasts in M7 and TMD cases have erythroid and megakaryocytic phenotypes.
1	Erythroid	Erythroid	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
2	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
3	specific	specific	ADJ	JJ	Degree=Pos	_	_	_	_
4	mRNAs	mRNA	NOUN	NNS	Number=Plur	_	_	_	_
5	encoding	encod	VERB	VBG	VerbForm=Ger	_	_	_	_
6	gamma	gamma	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
7	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
8	globin	globin	NOUN	NN	Number=Sing	_	_	_	_
9	and	and	CCONJ	CC	_	_	_	_	_
10	erythroid	erythroid	ADJ	JJ	Degree=Pos	_	_	_	_
11	delta-	delta-	PUNCT	,	_	_	_	_	SpaceAfter=No
12	aminolevulinate	aminolevulinate	ADJ	JJ	Degree=Pos	_	_	_	_
13	synthase	synthase	NOUN	NN	Number=Sing	_	_	_	_
14	were	be	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
15	found	find	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
16	to	to	PART	TO	_	_	_	_	_
17	be	be	AUX	VB	VerbForm=Inf	_	_	_	_
18	expressed	express	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
19	in	in	ADP	IN	_	_	_	_	_
20	blasts	blast	NOUN	NNS	Number=Plur	_	_	_	_
21	from	from	ADP	IN	_	_	_	_	_
22	most	most	ADJ	JJS	Degree=Sup	_	_	_	_
23	of	of	ADP	IN	_	_	_	_	_
24	these	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
25	cases	case	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
26	,	,	PUNCT	,	_	_	_	_	_
27	indicating	indicate	VERB	VBG	VerbForm=Ger	_	_	_	_
28	that	that	SCONJ	IN	_	_	_	_	_
29	majorities	majoritie	NOUN	NNS	Number=Plur	_	_	_	_
30	of	of	ADP	IN	_	_	_	_	_
31	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
32	blasts	blast	NOUN	NNS	Number=Plur	_	_	_	_
33	in	in	ADP	IN	_	_	_	_	_
34	M7	M7	NOUN	NN	Number=Sing	_	_	_	_
35	and	and	CCONJ	CC	_	_	_	_	_
36	TMD	tMd	NOUN	NN	Number=Sing	_	_	_	_
37	cases	cas	NOUN	NNS	Number=Plur	_	_	_	_
38	have	have	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
39	erythroid	erythroid	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
40	and	and	CCONJ	CC	_	_	_	_	_
41	megakaryocytic	megakaryocytic	ADJ	JJ	Degree=Pos	_	_	_	_
42	phenotypes	phenotype	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
43	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2699
# text = We also found that mRNAs encoding GATA-1 and GATA-2 are expressed in all these cases.
1	We	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
2	also	also	ADV	RB	_	_	_	_	_
3	found	find	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
4	that	that	SCONJ	IN	_	_	_	_	_
5	mRNAs	mRNAs	PROPN	NNPS	Number=Plur	_	_	_	_
6	encoding	encod	VERB	VBG	VerbForm=Ger	_	_	_	_
7	GATA	GATA	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
8	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
9	1	1	NUM	CD	NumType=Card	_	_	_	_
10	and	and	CCONJ	CC	_	_	_	_	_
11	GATA	GATa	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
12	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
13	2	2	NUM	CD	NumType=Card	_	_	_	_
14	are	be	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
15	expressed	express	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
16	in	in	ADP	IN	_	_	_	_	_
17	all	all	DET	PDT	_	_	_	_	_
18	these	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
19	cases	case	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
20	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2700
# text = These results suggest that M7 blasts and TMD blasts correspond to the erythroid/megakaryocytic bipotential progenitor cells.
1	These	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
2	results	result	NOUN	NNS	Number=Plur	_	_	_	_
3	suggest	suggest	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
4	that	that	SCONJ	IN	_	_	_	_	_
5	M7	M7	NUM	CD	NumType=Card	_	_	_	_
6	blasts	blast	NOUN	NNS	Number=Plur	_	_	_	_
7	and	and	CCONJ	CC	_	_	_	_	_
8	TMD	tMd	NOUN	NN	Number=Sing	_	_	_	_
9	blasts	blast	NOUN	NNS	Number=Plur	_	_	_	_
10	correspond	correspond	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
11	to	to	ADP	IN	_	_	_	_	_
12	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
13	erythroid	erythroid	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
14	/	/	PUNCT	,	_	_	_	_	SpaceAfter=No
15	megakaryocytic	megakaryocytic	ADJ	JJ	Degree=Pos	_	_	_	_
16	bipotential	bipotential	ADJ	JJ	Degree=Pos	_	_	_	_
17	progenitor	progenitor	NOUN	NN	Number=Sing	_	_	_	_
18	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
19	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 2701
# text = Document 003003299 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	003003299	003003299	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 2702
# text = Growth regulation and cellular changes during differentiation of human prostatic cancer LNCaP cells as induced by T lymphocyte-conditioned medium.
1	Growth	growth	NOUN	NN	Number=Sing	_	_	_	_
2	regulation	regulation	NOUN	NN	Number=Sing	_	_	_	_
3	and	and	CCONJ	CC	_	_	_	_	_
4	cellular	cellular	ADJ	JJ	Degree=Pos	_	_	_	_
5	changes	change	NOUN	NNS	Number=Plur	_	_	_	_
6	during	during	ADP	IN	_	_	_	_	_
7	differentiation	differentiation	NOUN	NN	Number=Sing	_	_	_	_
8	of	of	ADP	IN	_	_	_	_	_
9	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
10	prostatic	prostatic	ADJ	JJ	Degree=Pos	_	_	_	_
11	cancer	cancer	NOUN	NN	Number=Sing	_	_	_	_
12	LNCaP	Lncap	NOUN	NN	Number=Sing	_	_	_	_
13	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
14	as	as	SCONJ	IN	_	_	_	_	_
15	induced	induce	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
16	by	by	ADP	IN	_	_	_	_	_
17	T	t	PROPN	NNP	Number=Sing	_	_	_	_
18	lymphocyte	lymphocyte	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
19	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
20	conditioned	condition	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
21	medium	medium	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
22	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 2703
# text = Human prostatic epithelial cells from an androgen-dependent LNCaP cell line were examined in response to conditioned medium (CM) derived from phytohemagglutinin (PHA)-stimulated lymphocytes.
1	Human	human	ADJ	JJ	Degree=Pos	_	_	_	_
2	prostatic	prostatic	ADJ	JJ	Degree=Pos	_	_	_	_
3	epithelial	epithelial	ADJ	JJ	Degree=Pos	_	_	_	_
4	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
5	from	from	ADP	IN	_	_	_	_	_
6	an	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
7	androgen	androgen	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
8	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
9	dependent	dependent	ADJ	JJ	Degree=Pos	_	_	_	_
10	LNCaP	Lncap	NOUN	NN	Number=Sing	_	_	_	_
11	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
12	line	line	NOUN	NN	Number=Sing	_	_	_	_
13	were	be	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
14	examined	examin	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
15	in	in	ADP	IN	_	_	_	_	_
16	response	response	NOUN	NN	Number=Sing	_	_	_	_
17	to	to	ADP	IN	_	_	_	_	_
18	conditioned	condition	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
19	medium	medium	NOUN	NN	Number=Sing	_	_	_	_
20	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
21	CM	cm	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
22	)	)	PUNCT	-RRB-	_	_	_	_	_
23	derived	derive	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
24	from	from	ADP	IN	_	_	_	_	_
25	phytohemagglutinin	phytohemagglutinin	NOUN	NN	Number=Sing	_	_	_	_
26	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
27	PHA	PHA	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
28	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
29	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
30	stimulated	stimulate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
31	lymphocytes	lymphocyte	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
32	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2704
# text = Addition of CM caused a greater than 70% reduction of cell proliferation by cell counting and cell cycle.
1	Addition	Addition	PROPN	NNP	Number=Sing	_	_	_	_
2	of	of	ADP	IN	_	_	_	_	_
3	CM	cm	PROPN	NNP	Number=Sing	_	_	_	_
4	caused	cause	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
5	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
6	greater	greater	ADJ	JJR	Degree=Cmp	_	_	_	_
7	than	than	ADP	IN	_	_	_	_	_
8	70	70	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
9	%	%	SYM	NN	Number=Sing	_	_	_	_
10	reduction	reduction	NOUN	NN	Number=Sing	_	_	_	_
11	of	of	ADP	IN	_	_	_	_	_
12	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
13	proliferation	proliferation	NOUN	NN	Number=Sing	_	_	_	_
14	by	by	ADP	IN	_	_	_	_	_
15	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
16	counting	counting	NOUN	NN	Number=Sing	_	_	_	_
17	and	and	CCONJ	CC	_	_	_	_	_
18	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
19	cycle	cycle	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
20	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2705
# text = These cells showed G1 phase arrest and the clonogenicity was reduced.
1	These	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
2	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
3	showed	show	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
4	G1	G1	NUM	CD	NumType=Card	_	_	_	_
5	phase	phase	NOUN	NN	Number=Sing	_	_	_	_
6	arrest	arrest	NOUN	NN	Number=Sing	_	_	_	_
7	and	and	CCONJ	CC	_	_	_	_	_
8	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
9	clonogenicity	clonogenicity	NOUN	NN	Number=Sing	_	_	_	_
10	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
11	reduced	reduce	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	SpaceAfter=No
12	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2706
# text = The growth-modulating effect was dose-dependent and not due to cell lysis or apoptosis.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	growth	growth	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
3	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
4	modulating	modulating	NOUN	NN	Number=Sing	_	_	_	_
5	effect	effect	NOUN	NN	Number=Sing	_	_	_	_
6	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
7	dose	dose	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
8	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
9	dependent	dependent	ADJ	JJ	Degree=Pos	_	_	_	_
10	and	and	CCONJ	CC	_	_	_	_	_
11	not	not	PART	RB	_	_	_	_	_
12	due	due	VERB	VB	VerbForm=Inf	_	_	_	_
13	to	to	PART	TO	_	_	_	_	_
14	cell	cell	VERB	VB	VerbForm=Inf	_	_	_	_
15	lysis	lysis	NOUN	NN	Number=Sing	_	_	_	_
16	or	or	CCONJ	CC	_	_	_	_	_
17	apoptosis	apoptosis	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
18	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2707
# text = The binding of androgen to androgen receptor on these cells showed approximately 50% reduction, underlining a proliferation reduction mechanism.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	binding	binding	NOUN	NN	Number=Sing	_	_	_	_
3	of	of	ADP	IN	_	_	_	_	_
4	androgen	androgen	NOUN	NN	Number=Sing	_	_	_	_
5	to	to	PART	TO	_	_	_	_	_
6	androgen	androgen	VERB	VB	VerbForm=Inf	_	_	_	_
7	receptor	receptor	NOUN	NN	Number=Sing	_	_	_	_
8	on	on	ADP	IN	_	_	_	_	_
9	these	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
10	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
11	showed	show	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
12	approximately	approximately	ADV	RB	_	_	_	_	_
13	50	50	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
14	%	%	SYM	NN	Number=Sing	_	_	_	_
15	reduction	reduction	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
16	,	,	PUNCT	,	_	_	_	_	_
17	underlining	underlin	VERB	VBG	VerbForm=Ger	_	_	_	_
18	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
19	proliferation	proliferation	NOUN	NN	Number=Sing	_	_	_	_
20	reduction	reduction	NOUN	NN	Number=Sing	_	_	_	_
21	mechanism	mechanism	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
22	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2708
# text = The prostate-specific antigen (PSA) was downregulated to approximately 75% during the process.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	prostate	prostate	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
3	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
4	specific	specific	ADJ	JJ	Degree=Pos	_	_	_	_
5	antigen	antigen	NOUN	NN	Number=Sing	_	_	_	_
6	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
7	PSA	PSa	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
8	)	)	PUNCT	-RRB-	_	_	_	_	_
9	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
10	downregulated	downregulate	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
11	to	to	ADP	IN	_	_	_	_	_
12	approximately	approximately	ADV	RB	_	_	_	_	_
13	75	75	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
14	%	%	SYM	NN	Number=Sing	_	_	_	_
15	during	during	ADP	IN	_	_	_	_	_
16	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
17	process	process	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
18	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2709
# text = Cell morphology showed dendritic processes extending from cytoplasm and other neuroendocrine cell characteristics.
1	Cell	cell	NOUN	NN	Number=Sing	_	_	_	_
2	morphology	morphology	NOUN	NN	Number=Sing	_	_	_	_
3	showed	show	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
4	dendritic	dendritic	ADJ	JJ	Degree=Pos	_	_	_	_
5	processes	process	NOUN	NNS	Number=Plur	_	_	_	_
6	extending	extend	VERB	VBG	VerbForm=Ger	_	_	_	_
7	from	from	ADP	IN	_	_	_	_	_
8	cytoplasm	cytoplasm	NOUN	NN	Number=Sing	_	_	_	_
9	and	and	CCONJ	CC	_	_	_	_	_
10	other	other	ADJ	JJ	Degree=Pos	_	_	_	_
11	neuroendocrine	neuroendocrine	NOUN	NN	Number=Sing	_	_	_	_
12	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
13	characteristics	characteristic	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
14	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2710
# text = The expression of several cytoskeleton and intracellular proteins increased as determined by immunostaining on slides and by ELISA procedures.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
3	of	of	ADP	IN	_	_	_	_	_
4	several	several	ADJ	JJ	Degree=Pos	_	_	_	_
5	cytoskeleton	cytoskeleton	NOUN	NN	Number=Sing	_	_	_	_
6	and	and	CCONJ	CC	_	_	_	_	_
7	intracellular	intracellular	ADJ	JJ	Degree=Pos	_	_	_	_
8	proteins	protein	NOUN	NNS	Number=Plur	_	_	_	_
9	increased	increase	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
10	as	as	SCONJ	IN	_	_	_	_	_
11	determined	determine	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
12	by	by	SCONJ	IN	_	_	_	_	_
13	immunostaining	immunostain	VERB	VBG	VerbForm=Ger	_	_	_	_
14	on	on	ADP	IN	_	_	_	_	_
15	slides	slide	NOUN	NNS	Number=Plur	_	_	_	_
16	and	and	CCONJ	CC	_	_	_	_	_
17	by	by	ADP	IN	_	_	_	_	_
18	ELISA	ELISA	PROPN	NNP	Number=Sing	_	_	_	_
19	procedures	procedure	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
20	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2711
# text = These included vimentin, correlating to cell shape changes, cytokeratins 8 and 18, associated with differentiated cell types of prostate epithelia, and neuron-specific enolase and serotonin, associated with neuroendocrine cells.
1	These	these	PRON	DT	Number=Plur|PronType=Dem	_	_	_	_
2	included	include	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
3	vimentin	vimentin	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
4	,	,	PUNCT	,	_	_	_	_	_
5	correlating	correlat	VERB	VBG	VerbForm=Ger	_	_	_	_
6	to	to	PART	TO	_	_	_	_	_
7	cell	cell	VERB	VB	VerbForm=Inf	_	_	_	_
8	shape	shape	NOUN	NN	Number=Sing	_	_	_	_
9	changes	change	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
10	,	,	PUNCT	,	_	_	_	_	_
11	cytokeratins	cytokeratin	NOUN	NNS	Number=Plur	_	_	_	_
12	8	8	NUM	CD	NumType=Card	_	_	_	_
13	and	and	CCONJ	CC	_	_	_	_	_
14	18	18	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
15	,	,	PUNCT	,	_	_	_	_	_
16	associated	associate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
17	with	with	ADP	IN	_	_	_	_	_
18	differentiated	differentiate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
19	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
20	types	type	NOUN	NNS	Number=Plur	_	_	_	_
21	of	of	ADP	IN	_	_	_	_	_
22	prostate	prostate	NOUN	NN	Number=Sing	_	_	_	_
23	epithelia	epithelia	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
24	,	,	PUNCT	,	_	_	_	_	_
25	and	and	CCONJ	CC	_	_	_	_	_
26	neuron	neuron	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
27	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
28	specific	specific	ADJ	JJ	Degree=Pos	_	_	_	_
29	enolase	enolase	NOUN	NN	Number=Sing	_	_	_	_
30	and	and	CCONJ	CC	_	_	_	_	_
31	serotonin	serotonin	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
32	,	,	PUNCT	,	_	_	_	_	_
33	associated	associate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
34	with	with	ADP	IN	_	_	_	_	_
35	neuroendocrine	neuroendocrine	NOUN	NN	Number=Sing	_	_	_	_
36	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
37	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2712
# text = From these cellular changes, we can infer that the cell growth was modulated along with induction of terminal differentiation.
1	From	from	ADP	IN	_	_	_	_	_
2	these	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
3	cellular	cellular	ADJ	JJ	Degree=Pos	_	_	_	_
4	changes	change	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
5	,	,	PUNCT	,	_	_	_	_	_
6	we	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
7	can	can	AUX	MD	VerbForm=Fin	_	_	_	_
8	infer	infer	VERB	VB	VerbForm=Inf	_	_	_	_
9	that	that	SCONJ	IN	_	_	_	_	_
10	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
11	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
12	growth	growth	NOUN	NN	Number=Sing	_	_	_	_
13	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
14	modulated	modulate	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
15	along	along	ADP	IN	_	_	_	_	_
16	with	with	ADP	IN	_	_	_	_	_
17	induction	induction	NOUN	NN	Number=Sing	_	_	_	_
18	of	of	ADP	IN	_	_	_	_	_
19	terminal	terminal	ADJ	JJ	Degree=Pos	_	_	_	_
20	differentiation	differentiation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
21	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2713
# text = Activated T cells were demonstrated to be important in providing the modulating activity.
1	Activated	activate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
2	T	t	PROPN	NNP	Number=Sing	_	_	_	_
3	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
4	were	be	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
5	demonstrated	demonstrate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
6	to	to	PART	TO	_	_	_	_	_
7	be	be	AUX	VB	VerbForm=Inf	_	_	_	_
8	important	important	ADJ	JJ	Degree=Pos	_	_	_	_
9	in	in	SCONJ	IN	_	_	_	_	_
10	providing	provide	VERB	VBG	VerbForm=Ger	_	_	_	_
11	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
12	modulating	modulating	ADJ	JJ	Degree=Pos	_	_	_	_
13	activity	activity	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
14	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2714
# text = This growth modulator was semipurified and had an estimated molecular weight 13,000 to 24,000 Da.
1	This	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
2	growth	growth	NOUN	NN	Number=Sing	_	_	_	_
3	modulator	modulator	NOUN	NN	Number=Sing	_	_	_	_
4	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
5	semipurified	semipurify	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
6	and	and	CCONJ	CC	_	_	_	_	_
7	had	have	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
8	an	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
9	estimated	estimate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
10	molecular	molecular	NOUN	NN	Number=Sing	_	_	_	_
11	weight	weight	NOUN	NN	Number=Sing	_	_	_	_
12	13,000	13,000	NUM	CD	NumType=Card	_	_	_	_
13	to	to	ADP	IN	_	_	_	_	_
14	24,000	24,000	NUM	CD	NumType=Card	_	_	_	_
15	Da	da	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
16	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2715
# text = The activity was determined to be distinct from TGF, TNF, and some commonly known lymphokines.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	activity	activity	NOUN	NN	Number=Sing	_	_	_	_
3	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
4	determined	determine	ADJ	JJ	Degree=Pos	_	_	_	_
5	to	to	PART	TO	_	_	_	_	_
6	be	be	AUX	VB	VerbForm=Inf	_	_	_	_
7	distinct	distinct	ADJ	JJ	Degree=Pos	_	_	_	_
8	from	from	ADP	IN	_	_	_	_	_
9	TGF	TGF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
10	,	,	PUNCT	,	_	_	_	_	_
11	TNF	TNF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
12	,	,	PUNCT	,	_	_	_	_	_
13	and	and	CCONJ	CC	_	_	_	_	_
14	some	some	DET	DT	_	_	_	_	_
15	commonly	commonly	ADV	RB	_	_	_	_	_
16	known	know	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
17	lymphokines	lymphokine	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
18	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2716
# text = The interaction between lymphoid and prostatic cells in growth and development is described.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	interaction	interaction	NOUN	NN	Number=Sing	_	_	_	_
3	between	between	ADP	IN	_	_	_	_	_
4	lymphoid	lymphoid	NOUN	NN	Number=Sing	_	_	_	_
5	and	and	CCONJ	CC	_	_	_	_	_
6	prostatic	prostatic	ADJ	JJ	Degree=Pos	_	_	_	_
7	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
8	in	in	ADP	IN	_	_	_	_	_
9	growth	growth	NOUN	NN	Number=Sing	_	_	_	_
10	and	and	CCONJ	CC	_	_	_	_	_
11	development	development	NOUN	NN	Number=Sing	_	_	_	_
12	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
13	described	describe	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	SpaceAfter=No
14	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 2717
# text = Document 003003300 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	003003300	003003300	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 2718
# text = Two distinct forms of active transcription factor CREB (cAMP response element binding protein).
1	Two	two	NUM	CD	NumType=Card	_	_	_	_
2	distinct	distinct	ADJ	JJ	Degree=Pos	_	_	_	_
3	forms	form	NOUN	NNS	Number=Plur	_	_	_	_
4	of	of	ADP	IN	_	_	_	_	_
5	active	active	ADJ	JJ	Degree=Pos	_	_	_	_
6	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
7	factor	factor	NOUN	NN	Number=Sing	_	_	_	_
8	CREB	Creb	NOUN	NN	Number=Sing	_	_	_	_
9	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
10	cAMP	camp	NOUN	NN	Number=Sing	_	_	_	_
11	response	response	NOUN	NN	Number=Sing	_	_	_	_
12	element	element	NOUN	NN	Number=Sing	_	_	_	_
13	binding	bind	VERB	VBG	VerbForm=Ger	_	_	_	_
14	protein	protein	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
15	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
16	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 2719
# text = Mammalian cells express two distinct forms of transcription factor CREB (cAMP response element binding protein) that are apparently the products of alternative splicing of the CREB gene transcript.
1	Mammalian	Mammalian	ADJ	JJ	Degree=Pos	_	_	_	_
2	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
3	express	express	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
4	two	two	NUM	CD	NumType=Card	_	_	_	_
5	distinct	distinct	ADJ	JJ	Degree=Pos	_	_	_	_
6	forms	form	NOUN	NNS	Number=Plur	_	_	_	_
7	of	of	ADP	IN	_	_	_	_	_
8	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
9	factor	factor	NOUN	NN	Number=Sing	_	_	_	_
10	CREB	Creb	NOUN	NN	Number=Sing	_	_	_	_
11	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
12	cAMP	camp	NOUN	NN	Number=Sing	_	_	_	_
13	response	response	NOUN	NN	Number=Sing	_	_	_	_
14	element	element	NOUN	NN	Number=Sing	_	_	_	_
15	binding	bind	VERB	VBG	VerbForm=Ger	_	_	_	_
16	protein	protein	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
17	)	)	PUNCT	-RRB-	_	_	_	_	_
18	that	that	PRON	WDT	PronType=Rel	_	_	_	_
19	are	be	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
20	apparently	apparently	ADV	RB	_	_	_	_	_
21	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
22	products	product	NOUN	NNS	Number=Plur	_	_	_	_
23	of	of	ADP	IN	_	_	_	_	_
24	alternative	alternative	ADJ	JJ	Degree=Pos	_	_	_	_
25	splicing	splicing	NOUN	NN	Number=Sing	_	_	_	_
26	of	of	ADP	IN	_	_	_	_	_
27	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
28	CREB	CREB	PROPN	NNP	Number=Sing	_	_	_	_
29	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
30	transcript	transcript	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
31	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2720
# text = The two proteins differ by a 14-amino acid serine-rich insertion present in one of the CREB isoforms.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	two	two	NUM	CD	NumType=Card	_	_	_	_
3	proteins	protein	NOUN	NNS	Number=Plur	_	_	_	_
4	differ	differ	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
5	by	by	ADP	IN	_	_	_	_	_
6	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
7	14	14	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
8	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
9	amino	amino	NOUN	NN	Number=Sing	_	_	_	_
10	acid	acid	NOUN	NN	Number=Sing	_	_	_	_
11	serine	serine	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
12	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
13	rich	rich	ADJ	JJ	Degree=Pos	_	_	_	_
14	insertion	insertion	NOUN	NN	Number=Sing	_	_	_	_
15	present	present	ADJ	JJ	Degree=Pos	_	_	_	_
16	in	in	ADP	IN	_	_	_	_	_
17	one	one	NUM	CD	NumType=Card	_	_	_	_
18	of	of	ADP	IN	_	_	_	_	_
19	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
20	CREB	CREB	PROPN	NNP	Number=Sing	_	_	_	_
21	isoforms	isoform	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
22	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2721
# text = We show that both CREB isoforms are expressed in many cell types and mammalian species.
1	We	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
2	show	show	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
3	that	that	SCONJ	IN	_	_	_	_	_
4	both	both	DET	DT	_	_	_	_	_
5	CREB	Creb	NOUN	NN	Number=Sing	_	_	_	_
6	isoforms	isoform	NOUN	NNS	Number=Plur	_	_	_	_
7	are	be	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
8	expressed	express	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
9	in	in	ADP	IN	_	_	_	_	_
10	many	many	ADJ	JJ	Degree=Pos	_	_	_	_
11	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
12	types	type	NOUN	NNS	Number=Plur	_	_	_	_
13	and	and	CCONJ	CC	_	_	_	_	_
14	mammalian	mammalian	ADJ	JJ	Degree=Pos	_	_	_	_
15	species	species	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
16	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2722
# text = Both encode proteins that bind specifically to a cAMP response element in vitro.
1	Both	both	DET	DT	_	_	_	_	_
2	encode	encode	NOUN	NN	Number=Sing	_	_	_	_
3	proteins	protein	NOUN	NNS	Number=Plur	_	_	_	_
4	that	that	PRON	WDT	PronType=Rel	_	_	_	_
5	bind	bind	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
6	specifically	specifically	ADV	RB	_	_	_	_	_
7	to	to	ADP	IN	_	_	_	_	_
8	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
9	cAMP	camp	NOUN	NN	Number=Sing	_	_	_	_
10	response	response	NOUN	NN	Number=Sing	_	_	_	_
11	element	element	NOUN	NN	Number=Sing	_	_	_	_
12	in	in	ADP	IN	_	_	_	_	_
13	vitro	vitro	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
14	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2723
# text = As expected for proteins of this class, the CREB proteins bind DNA as dimers.
1	As	as	SCONJ	IN	_	_	_	_	_
2	expected	expect	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
3	for	for	ADP	IN	_	_	_	_	_
4	proteins	protein	NOUN	NNS	Number=Plur	_	_	_	_
5	of	of	ADP	IN	_	_	_	_	_
6	this	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
7	class	class	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
8	,	,	PUNCT	,	_	_	_	_	_
9	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
10	CREB	CREB	ADJ	JJ	Degree=Pos	_	_	_	_
11	proteins	protein	NOUN	NNS	Number=Plur	_	_	_	_
12	bind	bind	ADP	IN	_	_	_	_	_
13	DNA	dna	NOUN	NN	Number=Sing	_	_	_	_
14	as	as	ADP	IN	_	_	_	_	_
15	dimers	dimer	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
16	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2724
# text = Both proteins impart cAMP-regulated transcriptional activity to a heterologous DNA-binding domain, showing that cAMP directly modulates the transcriptional stimulatory activity of CREB.
1	Both	both	DET	DT	_	_	_	_	_
2	proteins	protein	NOUN	NNS	Number=Plur	_	_	_	_
3	impart	impart	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
4	cAMP	camp	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
5	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
6	regulated	regulate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
7	transcriptional	transcriptional	ADJ	JJ	Degree=Pos	_	_	_	_
8	activity	activity	NOUN	NN	Number=Sing	_	_	_	_
9	to	to	ADP	IN	_	_	_	_	_
10	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
11	heterologous	heterologous	ADJ	JJ	Degree=Pos	_	_	_	_
12	DNA	dna	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
13	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
14	binding	binding	VERB	VBG	VerbForm=Ger	_	_	_	_
15	domain	domain	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
16	,	,	PUNCT	,	_	_	_	_	_
17	showing	show	VERB	VBG	VerbForm=Ger	_	_	_	_
18	that	that	SCONJ	IN	_	_	_	_	_
19	cAMP	camp	PROPN	NNP	Number=Sing	_	_	_	_
20	directly	directly	ADV	RB	_	_	_	_	_
21	modulates	modulate	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
22	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
23	transcriptional	transcriptional	ADJ	JJ	Degree=Pos	_	_	_	_
24	stimulatory	stimulatory	ADJ	JJ	Degree=Pos	_	_	_	_
25	activity	activity	NOUN	NN	Number=Sing	_	_	_	_
26	of	of	ADP	IN	_	_	_	_	_
27	CREB	CREB	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
28	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2725
# text = The presence of multiple CREB isoforms with identical DNA-binding specificities but differences in the presumed regulatory domain raises the possibility that CREB proteins may be able to integrate distinct regulatory signals at the level of gene transcription.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	presence	presence	NOUN	NN	Number=Sing	_	_	_	_
3	of	of	ADP	IN	_	_	_	_	_
4	multiple	multiple	ADJ	JJ	Degree=Pos	_	_	_	_
5	CREB	Creb	NOUN	NN	Number=Sing	_	_	_	_
6	isoforms	isoform	NOUN	NNS	Number=Plur	_	_	_	_
7	with	with	ADP	IN	_	_	_	_	_
8	identical	identical	ADJ	JJ	Degree=Pos	_	_	_	_
9	DNA	dna	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
10	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
11	binding	bind	VERB	VBG	VerbForm=Ger	_	_	_	_
12	specificities	specificity	NOUN	NNS	Number=Plur	_	_	_	_
13	but	but	CCONJ	CC	_	_	_	_	_
14	differences	difference	NOUN	NNS	Number=Plur	_	_	_	_
15	in	in	ADP	IN	_	_	_	_	_
16	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
17	presumed	presume	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
18	regulatory	regulatory	ADJ	JJ	Degree=Pos	_	_	_	_
19	domain	domain	NOUN	NN	Number=Sing	_	_	_	_
20	raises	raise	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
21	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
22	possibility	possibility	NOUN	NN	Number=Sing	_	_	_	_
23	that	that	PRON	WDT	PronType=Rel	_	_	_	_
24	CREB	CREB	PROPN	NNP	Number=Sing	_	_	_	_
25	proteins	protein	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
26	may	may	AUX	MD	VerbForm=Fin	_	_	_	_
27	be	be	AUX	VB	VerbForm=Inf	_	_	_	_
28	able	able	ADJ	JJ	Degree=Pos	_	_	_	_
29	to	to	PART	TO	_	_	_	_	_
30	integrate	integrate	VERB	VB	VerbForm=Inf	_	_	_	_
31	distinct	distinct	ADJ	JJ	Degree=Pos	_	_	_	_
32	regulatory	regulatory	ADJ	JJ	Degree=Pos	_	_	_	_
33	signals	signal	NOUN	NNS	Number=Plur	_	_	_	_
34	at	at	ADP	IN	_	_	_	_	_
35	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
36	level	level	NOUN	NN	Number=Sing	_	_	_	_
37	of	of	ADP	IN	_	_	_	_	_
38	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
39	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
40	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 2726
# text = Document 003003302 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	003003302	003003302	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 2727
# text = Transcription factors as targets for oxidative signalling during lymphocyte activation.
1	Transcription	Transcription	NOUN	NN	Number=Sing	_	_	_	_
2	factors	factor	NOUN	NNS	Number=Plur	_	_	_	_
3	as	as	ADP	IN	_	_	_	_	_
4	targets	target	NOUN	NNS	Number=Plur	_	_	_	_
5	for	for	ADP	IN	_	_	_	_	_
6	oxidative	oxidative	ADJ	JJ	Degree=Pos	_	_	_	_
7	signalling	signalling	NOUN	NN	Number=Sing	_	_	_	_
8	during	during	ADP	IN	_	_	_	_	_
9	lymphocyte	lymphocyte	NOUN	NN	Number=Sing	_	_	_	_
10	activation	activation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
11	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 2728
# text = We previously have demonstrated a requirement for oxidative events during cell cycle entry in T lymphocytes and have hypothesised that reactive oxygen species may act as intracellular signalling agents during lymphocyte activation.
1	We	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
2	previously	previously	ADV	RB	_	_	_	_	_
3	have	have	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
4	demonstrated	demonstrate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
5	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
6	requirement	requirement	NOUN	NN	Number=Sing	_	_	_	_
7	for	for	ADP	IN	_	_	_	_	_
8	oxidative	oxidative	ADJ	JJ	Degree=Pos	_	_	_	_
9	events	event	NOUN	NNS	Number=Plur	_	_	_	_
10	during	during	ADP	IN	_	_	_	_	_
11	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
12	cycle	cycle	NOUN	NN	Number=Sing	_	_	_	_
13	entry	entry	NOUN	NN	Number=Sing	_	_	_	_
14	in	in	ADP	IN	_	_	_	_	_
15	T	T	PROPN	NNP	Number=Sing	_	_	_	_
16	lymphocytes	lymphocyte	NOUN	NNS	Number=Plur	_	_	_	_
17	and	and	CCONJ	CC	_	_	_	_	_
18	have	have	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
19	hypothesised	hypothesise	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
20	that	that	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
21	reactive	reactive	ADJ	JJ	Degree=Pos	_	_	_	_
22	oxygen	oxygen	NOUN	NN	Number=Sing	_	_	_	_
23	species	species	NOUN	NNS	Number=Plur	_	_	_	_
24	may	may	AUX	MD	VerbForm=Fin	_	_	_	_
25	act	act	VERB	VB	VerbForm=Inf	_	_	_	_
26	as	as	ADP	IN	_	_	_	_	_
27	intracellular	intracelular	ADJ	JJ	Degree=Pos	_	_	_	_
28	signalling	signall	NOUN	NN	Number=Sing	_	_	_	_
29	agents	agent	NOUN	NNS	Number=Plur	_	_	_	_
30	during	during	ADP	IN	_	_	_	_	_
31	lymphocyte	lymphocyte	NOUN	NN	Number=Sing	_	_	_	_
32	activation	activation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
33	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2729
# text = In the current study, cysteamine, an aminothiol compound with antioxidant activity, has been used to further investigate the role of oxidative signalling during lymphocyte activation.
1	In	in	ADP	IN	_	_	_	_	_
2	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
3	current	current	ADJ	JJ	Degree=Pos	_	_	_	_
4	study	study	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
5	,	,	PUNCT	,	_	_	_	_	_
6	cysteamine	cysteamine	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
7	,	,	PUNCT	,	_	_	_	_	_
8	an	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
9	aminothiol	aminothiol	ADJ	JJ	Degree=Pos	_	_	_	_
10	compound	compound	NOUN	NN	Number=Sing	_	_	_	_
11	with	with	ADP	IN	_	_	_	_	_
12	antioxidant	antioxidant	ADJ	JJ	Degree=Pos	_	_	_	_
13	activity	activity	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
14	,	,	PUNCT	,	_	_	_	_	_
15	has	have	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
16	been	be	AUX	VBN	Tense=Past|VerbForm=Part	_	_	_	_
17	used	use	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
18	to	to	PART	TO	_	_	_	_	_
19	further	further	ADV	RB	_	_	_	_	_
20	investigate	investigate	VERB	VB	VerbForm=Inf	_	_	_	_
21	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
22	role	role	NOUN	NN	Number=Sing	_	_	_	_
23	of	of	ADP	IN	_	_	_	_	_
24	oxidative	oxidative	ADJ	JJ	Degree=Pos	_	_	_	_
25	signalling	signalling	NOUN	NN	Number=Sing	_	_	_	_
26	during	during	ADP	IN	_	_	_	_	_
27	lymphocyte	lymphocyte	NOUN	NN	Number=Sing	_	_	_	_
28	activation	activation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
29	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2730
# text = Treatment of normal human peripheral blood lymphocytes with cysteamine in vitro was found to inhibit proliferation in a dose-dependent manner, with essentially complete inhibition occurring at a dose of 400 microM.
1	Treatment	treatment	NOUN	NN	Number=Sing	_	_	_	_
2	of	of	ADP	IN	_	_	_	_	_
3	normal	normal	ADJ	JJ	Degree=Pos	_	_	_	_
4	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
5	peripheral	peripheral	ADJ	JJ	Degree=Pos	_	_	_	_
6	blood	blood	NOUN	NN	Number=Sing	_	_	_	_
7	lymphocytes	lymphocyte	NOUN	NNS	Number=Plur	_	_	_	_
8	with	with	ADP	IN	_	_	_	_	_
9	cysteamine	cysteamine	NOUN	NN	Number=Sing	_	_	_	_
10	in	in	ADP	IN	_	_	_	_	_
11	vitro	vitro	NOUN	NN	Number=Sing	_	_	_	_
12	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
13	found	find	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
14	to	to	PART	TO	_	_	_	_	_
15	inhibit	inhibit	VERB	VB	VerbForm=Inf	_	_	_	_
16	proliferation	proliferation	NOUN	NN	Number=Sing	_	_	_	_
17	in	in	ADP	IN	_	_	_	_	_
18	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
19	dose	dose	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
20	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
21	dependent	dependent	ADJ	JJ	Degree=Pos	_	_	_	_
22	manner	manner	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
23	,	,	PUNCT	,	_	_	_	_	_
24	with	with	ADP	IN	_	_	_	_	_
25	essentially	essentially	ADV	RB	_	_	_	_	_
26	complete	complete	ADJ	JJ	Degree=Pos	_	_	_	_
27	inhibition	inhibition	NOUN	NN	Number=Sing	_	_	_	_
28	occurring	occurre	VERB	VBG	VerbForm=Ger	_	_	_	_
29	at	at	ADP	IN	_	_	_	_	_
30	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
31	dose	dose	NOUN	NN	Number=Sing	_	_	_	_
32	of	of	ADP	IN	_	_	_	_	_
33	400	400	NUM	CD	NumType=Card	_	_	_	_
34	microM	microm	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
35	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2731
# text = This inhibitory effect was limited to the first 2 h after mitogenic activation, localizing the time-frame of action of cysteamine to within the commitment period.
1	This	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
2	inhibitory	inhibitory	ADJ	JJ	Degree=Pos	_	_	_	_
3	effect	effect	NOUN	NN	Number=Sing	_	_	_	_
4	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
5	limited	limit	ADJ	JJ	Degree=Pos	_	_	_	_
6	to	to	ADP	IN	_	_	_	_	_
7	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
8	first	first	ADJ	JJ	Degree=Pos|NumType=Ord	_	_	_	_
9	2	2	NUM	CD	NumType=Card	_	_	_	_
10	h	h	NOUN	NN	Number=Sing	_	_	_	_
11	after	after	ADP	IN	_	_	_	_	_
12	mitogenic	mitogenic	ADJ	JJ	Degree=Pos	_	_	_	_
13	activation	activation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
14	,	,	PUNCT	,	_	_	_	_	_
15	localizing	localize	VERB	VBG	VerbForm=Ger	_	_	_	_
16	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
17	time	time	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
18	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
19	frame	frame	NOUN	NN	Number=Sing	_	_	_	_
20	of	of	ADP	IN	_	_	_	_	_
21	action	action	NOUN	NN	Number=Sing	_	_	_	_
22	of	of	ADP	IN	_	_	_	_	_
23	cysteamine	cysteamine	NOUN	NN	Number=Sing	_	_	_	_
24	to	to	ADP	IN	_	_	_	_	_
25	within	within	ADP	IN	_	_	_	_	_
26	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
27	commitment	commitment	NOUN	NN	Number=Sing	_	_	_	_
28	period	period	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
29	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2732
# text = It therefore was of interest to establish which, if any, commitment events were affected by oxidative signalling during cell cycle entry.
1	It	it	PRON	PRP	Case=Nom|Gender=Neut|Number=Sing|Person=3|PronType=Prs	_	_	_	_
2	therefore	therefore	ADV	RB	_	_	_	_	_
3	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
4	of	of	ADP	IN	_	_	_	_	_
5	interest	interest	NOUN	NN	Number=Sing	_	_	_	_
6	to	to	PART	TO	_	_	_	_	_
7	establish	establish	VERB	VB	VerbForm=Inf	_	_	_	_
8	which	which	PRON	WDT	PronType=Int	_	_	_	SpaceAfter=No
9	,	,	PUNCT	,	_	_	_	_	_
10	if	if	SCONJ	IN	_	_	_	_	_
11	any	any	DET	DT	_	_	_	_	SpaceAfter=No
12	,	,	PUNCT	,	_	_	_	_	_
13	commitment	commitment	NOUN	NN	Number=Sing	_	_	_	_
14	events	event	NOUN	NNS	Number=Plur	_	_	_	_
15	were	be	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
16	affected	affect	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
17	by	by	ADP	IN	_	_	_	_	_
18	oxidative	oxidative	ADJ	JJ	Degree=Pos	_	_	_	_
19	signalling	signalling	NOUN	NN	Number=Sing	_	_	_	_
20	during	during	ADP	IN	_	_	_	_	_
21	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
22	cycle	cycle	NOUN	NN	Number=Sing	_	_	_	_
23	entry	entry	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
24	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2733
# text = Taking the IL-2 gene as a candidate, we examined the effect of cysteamine treatment on early gene expression during lymphocyte activation, and on the activity of transcription factors AP-1, NF-kappa B, NF-AT and Oct1, whose functions are required for expression of the IL-2 mRNA.
1	Taking	take	VERB	VBG	VerbForm=Ger	_	_	_	_
2	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
3	IL	Il	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
4	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
5	2	2	NUM	CD	NumType=Card	_	_	_	_
6	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
7	as	as	ADP	IN	_	_	_	_	_
8	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
9	candidate	candidate	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
10	,	,	PUNCT	,	_	_	_	_	_
11	we	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
12	examined	examin	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
13	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
14	effect	effect	NOUN	NN	Number=Sing	_	_	_	_
15	of	of	ADP	IN	_	_	_	_	_
16	cysteamine	cysteamine	NOUN	NN	Number=Sing	_	_	_	_
17	treatment	treatment	NOUN	NN	Number=Sing	_	_	_	_
18	on	on	ADP	IN	_	_	_	_	_
19	early	early	ADJ	JJ	Degree=Pos	_	_	_	_
20	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
21	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
22	during	during	ADP	IN	_	_	_	_	_
23	lymphocyte	lymphocyte	NOUN	NN	Number=Sing	_	_	_	_
24	activation	activation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
25	,	,	PUNCT	,	_	_	_	_	_
26	and	and	CCONJ	CC	_	_	_	_	_
27	on	on	ADP	IN	_	_	_	_	_
28	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
29	activity	activity	NOUN	NN	Number=Sing	_	_	_	_
30	of	of	ADP	IN	_	_	_	_	_
31	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
32	factors	factor	NOUN	NNS	Number=Plur	_	_	_	_
33	AP	ap	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
34	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
35	1	1	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
36	,	,	PUNCT	,	_	_	_	_	_
37	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
38	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
39	kappa	kappa	PROPN	NNP	Number=Sing	_	_	_	_
40	B	B	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
41	,	,	PUNCT	,	_	_	_	_	_
42	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
43	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
44	AT	at	PROPN	NNP	Number=Sing	_	_	_	_
45	and	and	CCONJ	CC	_	_	_	_	_
46	Oct1	Oct1	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
47	,	,	PUNCT	,	_	_	_	_	_
48	whose	whose	PRON	WP$	Poss=Yes|PronType=Int	_	_	_	_
49	functions	function	NOUN	NNS	Number=Plur	_	_	_	_
50	are	be	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
51	required	require	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
52	for	for	ADP	IN	_	_	_	_	_
53	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
54	of	of	ADP	IN	_	_	_	_	_
55	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
56	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
57	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
58	2	2	NUM	CD	NumType=Card	_	_	_	_
59	mRNA	mRNa	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
60	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2734
# text = Cysteamine treatment inhibited both expression of the IL-2 mRNA and secretion of IL-2 into the culture medium.
1	Cysteamine	Cysteamine	ADJ	JJ	Degree=Pos	_	_	_	_
2	treatment	treatment	NOUN	NN	Number=Sing	_	_	_	_
3	inhibited	inhibit	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
4	both	both	DET	DT	_	_	_	_	_
5	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
6	of	of	ADP	IN	_	_	_	_	_
7	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
8	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
9	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
10	2	2	NUM	CD	NumType=Card	_	_	_	_
11	mRNA	mRNa	NOUN	NN	Number=Sing	_	_	_	_
12	and	and	CCONJ	CC	_	_	_	_	_
13	secretion	secretion	NOUN	NN	Number=Sing	_	_	_	_
14	of	of	ADP	IN	_	_	_	_	_
15	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
16	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
17	2	2	NUM	CD	NumType=Card	_	_	_	_
18	into	into	ADP	IN	_	_	_	_	_
19	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
20	culture	culture	NOUN	NN	Number=Sing	_	_	_	_
21	medium	medium	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
22	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2735
# text = The inhibitory effect of cysteamine may be mediated at least in part by an effect on transcription factor function, as the DNA binding activities of AP-1 and NF-kappa B extracted from mitogen-stimulated cells were significantly inhibited by cysteamine treatment.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	inhibitory	inhibitory	ADJ	JJ	Degree=Pos	_	_	_	_
3	effect	effect	NOUN	NN	Number=Sing	_	_	_	_
4	of	of	ADP	IN	_	_	_	_	_
5	cysteamine	cysteamine	NOUN	NN	Number=Sing	_	_	_	_
6	may	may	AUX	MD	VerbForm=Fin	_	_	_	_
7	be	be	AUX	VB	VerbForm=Inf	_	_	_	_
8	mediated	mediate	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
9	at	at	ADV	RB	_	_	_	_	_
10	least	least	ADV	RBS	Degree=Sup	_	_	_	_
11	in	in	ADP	IN	_	_	_	_	_
12	part	part	NOUN	NN	Number=Sing	_	_	_	_
13	by	by	ADP	IN	_	_	_	_	_
14	an	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
15	effect	effect	NOUN	NN	Number=Sing	_	_	_	_
16	on	on	ADP	IN	_	_	_	_	_
17	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
18	factor	factor	NOUN	NN	Number=Sing	_	_	_	_
19	function	function	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
20	,	,	PUNCT	,	_	_	_	_	_
21	as	as	SCONJ	IN	_	_	_	_	_
22	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
23	DNA	dna	NOUN	NN	Number=Sing	_	_	_	_
24	binding	bind	VERB	VBG	VerbForm=Ger	_	_	_	_
25	activities	activity	NOUN	NNS	Number=Plur	_	_	_	_
26	of	of	ADP	IN	_	_	_	_	_
27	AP	ap	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
28	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
29	1	1	NUM	CD	NumType=Card	_	_	_	_
30	and	and	CCONJ	CC	_	_	_	_	_
31	NF	Nf	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
32	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
33	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_
34	B	b	NOUN	NN	Number=Sing	_	_	_	_
35	extracted	extract	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
36	from	from	ADP	IN	_	_	_	_	_
37	mitogen	mitogen	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
38	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
39	stimulated	stimulate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
40	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
41	were	be	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
42	significantly	significantly	ADV	RB	_	_	_	_	_
43	inhibited	inhibit	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
44	by	by	ADP	IN	_	_	_	_	_
45	cysteamine	cysteamine	NOUN	NN	Number=Sing	_	_	_	_
46	treatment	treatment	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
47	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2736
# text = Interestingly, Oct1 and NF-AT DNA binding activity were not affected by cysteamine treatment, suggesting that oxidative signalling processes operate in a selective manner.
1	Interestingly	Interestingly	ADV	RB	_	_	_	_	SpaceAfter=No
2	,	,	PUNCT	,	_	_	_	_	_
3	Oct1	Oct1	PROPN	NNP	Number=Sing	_	_	_	_
4	and	and	CCONJ	CC	_	_	_	_	_
5	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
6	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
7	AT	AT	NOUN	NN	Number=Sing	_	_	_	_
8	DNA	dna	NOUN	NN	Number=Sing	_	_	_	_
9	binding	binding	VERB	VBG	VerbForm=Ger	_	_	_	_
10	activity	activity	NOUN	NN	Number=Sing	_	_	_	_
11	were	be	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
12	not	not	PART	RB	_	_	_	_	_
13	affected	affect	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
14	by	by	ADP	IN	_	_	_	_	_
15	cysteamine	cysteamine	NOUN	NN	Number=Sing	_	_	_	_
16	treatment	treatment	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
17	,	,	PUNCT	,	_	_	_	_	_
18	suggesting	suggest	VERB	VBG	VerbForm=Ger	_	_	_	_
19	that	that	SCONJ	IN	_	_	_	_	_
20	oxidative	oxidative	ADJ	JJ	Degree=Pos	_	_	_	_
21	signalling	signalling	NOUN	NN	Number=Sing	_	_	_	_
22	processes	process	NOUN	NNS	Number=Plur	_	_	_	_
23	operate	operate	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
24	in	in	ADP	IN	_	_	_	_	_
25	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
26	selective	selective	ADJ	JJ	Degree=Pos	_	_	_	_
27	manner	manner	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
28	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2737
# text = The identification of regulatory proteins, such as transcription factors, as molecular targets for oxidative signalling provides further evidence to implicate oxidative signalling as being intimately involved in the G0 to G1 phase transition in T lymphocytes.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	identification	identification	NOUN	NN	Number=Sing	_	_	_	_
3	of	of	ADP	IN	_	_	_	_	_
4	regulatory	regulatory	ADJ	JJ	Degree=Pos	_	_	_	_
5	proteins	protein	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
6	,	,	PUNCT	,	_	_	_	_	_
7	such	such	ADJ	JJ	Degree=Pos	_	_	_	_
8	as	as	ADP	IN	_	_	_	_	_
9	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
10	factors	factor	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
11	,	,	PUNCT	,	_	_	_	_	_
12	as	as	SCONJ	IN	_	_	_	_	_
13	molecular	molecular	ADJ	JJ	Degree=Pos	_	_	_	_
14	targets	target	NOUN	NNS	Number=Plur	_	_	_	_
15	for	for	ADP	IN	_	_	_	_	_
16	oxidative	oxidative	ADJ	JJ	Degree=Pos	_	_	_	_
17	signalling	signalling	NOUN	NN	Number=Sing	_	_	_	_
18	provides	provide	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
19	further	further	ADJ	JJ	Degree=Pos	_	_	_	_
20	evidence	evidence	NOUN	NN	Number=Sing	_	_	_	_
21	to	to	PART	TO	_	_	_	_	_
22	implicate	implicate	VERB	VB	VerbForm=Inf	_	_	_	_
23	oxidative	oxidative	ADJ	JJ	Degree=Pos	_	_	_	_
24	signalling	signalling	NOUN	NN	Number=Sing	_	_	_	_
25	as	as	SCONJ	IN	_	_	_	_	_
26	being	be	AUX	VBG	VerbForm=Ger	_	_	_	_
27	intimately	intimately	ADV	RB	_	_	_	_	_
28	involved	involved	ADJ	JJ	Degree=Pos	_	_	_	_
29	in	in	ADP	IN	_	_	_	_	_
30	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
31	G0	G0	PROPN	NNP	Number=Sing	_	_	_	_
32	to	to	ADP	IN	_	_	_	_	_
33	G1	G1	NUM	CD	NumType=Card	_	_	_	_
34	phase	phase	NOUN	NN	Number=Sing	_	_	_	_
35	transition	transition	NOUN	NN	Number=Sing	_	_	_	_
36	in	in	ADP	IN	_	_	_	_	_
37	T	t	PROPN	NNP	Number=Sing	_	_	_	_
38	lymphocytes	lymphocyte	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
39	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 2738
# text = Document 003003303 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	003003303	003003303	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 2739
# text = Constitutively activated Jak-STAT pathway in T cells transformed with HTLV-I.
1	Constitutively	Constitutively	ADV	RB	_	_	_	_	_
2	activated	activate	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
3	Jak	Jak	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
4	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
5	STAT	Stat	PROPN	NNP	Number=Sing	_	_	_	_
6	pathway	pathway	NOUN	NN	Number=Sing	_	_	_	_
7	in	in	ADP	IN	_	_	_	_	_
8	T	t	PROPN	NNP	Number=Sing	_	_	_	_
9	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
10	transformed	transform	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
11	with	with	ADP	IN	_	_	_	_	_
12	HTLV	HTLV	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
13	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
14	I	I	PRON	PRP	Case=Nom|Number=Sing|Person=1|PronType=Prs	_	_	_	SpaceAfter=No
15	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 2740
# text = Human T cell lymphotropic virus I (HTLV-I) is the etiological agent for adult T cell leukemia and tropical spastic paraparesis (also termed HTLV-I-associated myelopathy).
1	Human	human	PROPN	NNP	Number=Sing	_	_	_	_
2	T	T	PROPN	NNP	Number=Sing	_	_	_	_
3	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
4	lymphotropic	lymphotropic	NOUN	NN	Number=Sing	_	_	_	_
5	virus	virus	NOUN	NN	Number=Sing	_	_	_	_
6	I	I	PRON	PRP	Case=Nom|Number=Sing|Person=1|PronType=Prs	_	_	_	_
7	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
8	HTLV	HTLV	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
9	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
10	I	I	PRON	PRP	Case=Nom|Number=Sing|Person=1|PronType=Prs	_	_	_	SpaceAfter=No
11	)	)	PUNCT	-RRB-	_	_	_	_	_
12	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
13	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
14	etiological	etiological	ADJ	JJ	Degree=Pos	_	_	_	_
15	agent	agent	NOUN	NN	Number=Sing	_	_	_	_
16	for	for	ADP	IN	_	_	_	_	_
17	adult	adult	ADJ	JJ	Degree=Pos	_	_	_	_
18	T	t	PROPN	NNP	Number=Sing	_	_	_	_
19	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
20	leukemia	leukemia	NOUN	NN	Number=Sing	_	_	_	_
21	and	and	CCONJ	CC	_	_	_	_	_
22	tropical	tropical	ADJ	JJ	Degree=Pos	_	_	_	_
23	spastic	spastic	ADJ	JJ	Degree=Pos	_	_	_	_
24	paraparesis	paraparesis	NOUN	NN	Number=Sing	_	_	_	_
25	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
26	also	also	ADV	RB	_	_	_	_	_
27	termed	term	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
28	HTLV	HTLV	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
29	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
30	I	I	PRON	PRP	Case=Nom|Number=Sing|Person=1|PronType=Prs	_	_	_	SpaceAfter=No
31	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
32	associated	associate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
33	myelopathy	myelopathy	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
34	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
35	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2741
# text = HTLV-I-infected peripheral blood T cells exhibit an initial phase of interleukin-2 (IL-2)-dependent growth; over time, by an unknown mechanism, the cells become IL-2-independent.
1	HTLV	HTLV	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
2	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
3	I	I	PRON	PRP	Case=Nom|Number=Sing|Person=1|PronType=Prs	_	_	_	SpaceAfter=No
4	-	-	PUNCT	:	_	_	_	_	SpaceAfter=No
5	infected	infect	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
6	peripheral	peripheral	ADJ	JJ	Degree=Pos	_	_	_	_
7	blood	blood	NOUN	NN	Number=Sing	_	_	_	_
8	T	t	PROPN	NNP	Number=Sing	_	_	_	_
9	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
10	exhibit	exhibit	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
11	an	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
12	initial	initial	ADJ	JJ	Degree=Pos	_	_	_	_
13	phase	phase	NOUN	NN	Number=Sing	_	_	_	_
14	of	of	ADP	IN	_	_	_	_	_
15	interleukin	interleukin	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
16	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
17	2	2	NUM	CD	NumType=Card	_	_	_	_
18	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
19	IL	Il	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
20	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
21	2	2	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
22	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
23	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
24	dependent	dependent	ADJ	JJ	Degree=Pos	_	_	_	_
25	growth	growth	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
26	;	;	PUNCT	,	_	_	_	_	_
27	over	over	ADP	IN	_	_	_	_	_
28	time	time	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
29	,	,	PUNCT	,	_	_	_	_	_
30	by	by	ADP	IN	_	_	_	_	_
31	an	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
32	unknown	unknown	ADJ	JJ	Degree=Pos	_	_	_	_
33	mechanism	mechanism	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
34	,	,	PUNCT	,	_	_	_	_	_
35	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
36	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
37	become	become	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
38	IL	Il	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
39	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
40	2	2	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
41	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
42	independent.	independent	NOUN	NN	Number=Sing	_	_	_	_

# sent_id = 2742
# text = Whereas the Jak kinases Jak1 and Jak3 and the signal transducer and activator of transcription proteins Stat3 and Stat5 are activated in normal T cells in response to IL-2, this signaling pathway was constitutively activated in HTLV-I-transformed cells.
1	Whereas	whereas	SCONJ	IN	_	_	_	_	_
2	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
3	Jak	Jak	PROPN	NNP	Number=Sing	_	_	_	_
4	kinases	kinase	PROPN	NNPS	Number=Plur	_	_	_	_
5	Jak1	Jak1	PROPN	NNP	Number=Sing	_	_	_	_
6	and	and	CCONJ	CC	_	_	_	_	_
7	Jak3	Jak3	NUM	CD	NumType=Card	_	_	_	_
8	and	and	CCONJ	CC	_	_	_	_	_
9	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
10	signal	signal	ADJ	JJ	Degree=Pos	_	_	_	_
11	transducer	transducer	NOUN	NN	Number=Sing	_	_	_	_
12	and	and	CCONJ	CC	_	_	_	_	_
13	activator	activator	NOUN	NN	Number=Sing	_	_	_	_
14	of	of	ADP	IN	_	_	_	_	_
15	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
16	proteins	protein	NOUN	NNS	Number=Plur	_	_	_	_
17	Stat3	Stat3	NUM	CD	NumType=Card	_	_	_	_
18	and	and	CCONJ	CC	_	_	_	_	_
19	Stat5	stat5	PROPN	NNP	Number=Sing	_	_	_	_
20	are	be	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
21	activated	activate	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
22	in	in	ADP	IN	_	_	_	_	_
23	normal	normal	ADJ	JJ	Degree=Pos	_	_	_	_
24	T	t	PROPN	NNP	Number=Sing	_	_	_	_
25	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
26	in	in	ADP	IN	_	_	_	_	_
27	response	response	NOUN	NN	Number=Sing	_	_	_	_
28	to	to	ADP	IN	_	_	_	_	_
29	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
30	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
31	2	2	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
32	,	,	PUNCT	,	_	_	_	_	_
33	this	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
34	signaling	signaling	NOUN	NN	Number=Sing	_	_	_	_
35	pathway	pathway	NOUN	NN	Number=Sing	_	_	_	_
36	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
37	constitutively	constitutively	ADV	RB	_	_	_	_	_
38	activated	activate	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
39	in	in	ADP	IN	_	_	_	_	_
40	HTLV	HTLV	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
41	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
42	I	I	PRON	PRP	Case=Nom|Number=Sing|Person=1|PronType=Prs	_	_	_	SpaceAfter=No
43	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
44	transformed	transform	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
45	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
46	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2743
# text = In HTLV-I-infected cord blood lymphocytes, the transition from IL-2-dependent to IL-2-independent growth correlated with the acquisition of a constitutively activated Jak-STAT pathway, which suggests that this pathway participates in HTLV-I-mediated T cell transformation.
1	In	in	ADP	IN	_	_	_	_	_
2	HTLV	HTLV	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
3	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
4	I	I	PRON	PRP	Case=Nom|Number=Sing|Person=1|PronType=Prs	_	_	_	SpaceAfter=No
5	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
6	infected	infect	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
7	cord	cord	NOUN	NN	Number=Sing	_	_	_	_
8	blood	blood	NOUN	NN	Number=Sing	_	_	_	_
9	lymphocytes	lymphocyte	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
10	,	,	PUNCT	,	_	_	_	_	_
11	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
12	transition	transition	NOUN	NN	Number=Sing	_	_	_	_
13	from	from	ADP	IN	_	_	_	_	_
14	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
15	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
16	2	2	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
17	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
18	dependent	dependent	ADJ	JJ	Degree=Pos	_	_	_	_
19	to	to	ADP	IN	_	_	_	_	_
20	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
21	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
22	2	2	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
23	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
24	independent	independent	ADJ	JJ	Degree=Pos	_	_	_	_
25	growth	growth	NOUN	NN	Number=Sing	_	_	_	_
26	correlated	correlate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
27	with	with	ADP	IN	_	_	_	_	_
28	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
29	acquisition	acquisition	NOUN	NN	Number=Sing	_	_	_	_
30	of	of	ADP	IN	_	_	_	_	_
31	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
32	constitutively	constitutively	ADV	RB	_	_	_	_	_
33	activated	activate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
34	Jak	Jak	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
35	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
36	STAT	STAT	PROPN	NNP	Number=Sing	_	_	_	_
37	pathway	pathway	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
38	,	,	PUNCT	,	_	_	_	_	_
39	which	which	PRON	WDT	PronType=Rel	_	_	_	_
40	suggests	suggest	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
41	that	that	SCONJ	IN	_	_	_	_	_
42	this	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
43	pathway	pathway	NOUN	NN	Number=Sing	_	_	_	_
44	participates	participate	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
45	in	in	ADP	IN	_	_	_	_	_
46	HTLV	HTLV	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
47	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
48	I-	I-	SYM	SYM	_	_	_	_	SpaceAfter=No
49	mediated	mediate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
50	T	t	PROPN	NNP	Number=Sing	_	_	_	_
51	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
52	transformation	transformation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
53	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 2744
# text = Document 003003306 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	003003306	003003306	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 2745
# text = Characterization of a CD43/leukosialin-mediated pathway for inducing apoptosis in human T-lymphoblastoid cells.
1	Characterization	Characterization	NOUN	NN	Number=Sing	_	_	_	_
2	of	of	ADP	IN	_	_	_	_	_
3	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
4	CD43/leukosialin-	Cd43/leukosialin-	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
5	mediated	mediate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
6	pathway	pathway	NOUN	NN	Number=Sing	_	_	_	_
7	for	for	SCONJ	IN	_	_	_	_	_
8	inducing	induce	VERB	VBG	VerbForm=Ger	_	_	_	_
9	apoptosis	apoptosis	NOUN	NN	Number=Sing	_	_	_	_
10	in	in	ADP	IN	_	_	_	_	_
11	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
12	T-	T-	PUNCT	,	_	_	_	_	SpaceAfter=No
13	lymphoblastoid	lymphoblastoid	ADJ	JJ	Degree=Pos	_	_	_	_
14	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
15	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 2746
# text = The monoclonal antibody (mAb) J393 induces apoptosis in Jurkat T-cells.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	monoclonal	monoclonal	ADJ	JJ	Degree=Pos	_	_	_	_
3	antibody	antibody	NOUN	NN	Number=Sing	_	_	_	_
4	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
5	mAb	mAb	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
6	)	)	PUNCT	-RRB-	_	_	_	_	_
7	J393	J393	NUM	CD	NumType=Card	_	_	_	_
8	induces	induce	NOUN	NNS	Number=Plur	_	_	_	_
9	apoptosis	apoptosis	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
10	in	in	ADP	IN	_	_	_	_	_
11	Jurkat	Jurkat	PROPN	NNP	Number=Sing	_	_	_	_
12	T-	T-	PUNCT	,	_	_	_	_	SpaceAfter=No
13	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
14	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2747
# text = NH2-terminal amino acid sequence analysis identified the 140-kDa surface antigen for mAb J393 as CD43/leukosialin, the major sialoglycoprotein of leukocytes.
1	NH2	NH2	X	LS	_	_	_	_	SpaceAfter=No
2	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
3	terminal	terminal	ADJ	JJ	Degree=Pos	_	_	_	_
4	amino	amino	DET	DT	_	_	_	_	_
5	acid	acid	ADJ	JJ	Degree=Pos	_	_	_	_
6	sequence	sequence	NOUN	NN	Number=Sing	_	_	_	_
7	analysis	analysis	NOUN	NN	Number=Sing	_	_	_	_
8	identified	identify	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
9	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
10	140	140	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
11	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
12	kDa	kDa	NOUN	NN	Number=Sing	_	_	_	_
13	surface	surface	NOUN	NN	Number=Sing	_	_	_	_
14	antigen	antigen	NOUN	NN	Number=Sing	_	_	_	_
15	for	for	ADP	IN	_	_	_	_	_
16	mAb	mAb	PROPN	NNP	Number=Sing	_	_	_	_
17	J393	J393	NUM	CD	NumType=Card	_	_	_	_
18	as	as	ADP	IN	_	_	_	_	_
19	CD43	CD43	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
20	/	/	PUNCT	,	_	_	_	_	SpaceAfter=No
21	leukosialin	leukosialin	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
22	,	,	PUNCT	,	_	_	_	_	_
23	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
24	major	major	ADJ	JJ	Degree=Pos	_	_	_	_
25	sialoglycoprotein	sialoglycoprotein	NOUN	NN	Number=Sing	_	_	_	_
26	of	of	ADP	IN	_	_	_	_	_
27	leukocytes	leukocyte	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
28	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2748
# text = While Jurkat cells co-expressed two discrete cell-surface isoforms of CD43, recognized by mAb J393 and mAb G10-2, respectively, only J393/CD43 signaled apoptosis.
1	While	while	SCONJ	IN	_	_	_	_	_
2	Jurkat	Jurkat	PROPN	NNP	Number=Sing	_	_	_	_
3	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
4	co-expressed	co-express	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
5	two	two	NUM	CD	NumType=Card	_	_	_	_
6	discrete	discrete	NOUN	NN	Number=Sing	_	_	_	_
7	cell	cell	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
8	-surface	-surface	NOUN	NN	Number=Sing	_	_	_	_
9	isoforms	isoform	NOUN	NNS	Number=Plur	_	_	_	_
10	of	of	ADP	IN	_	_	_	_	_
11	CD43	CD43	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
12	,	,	PUNCT	,	_	_	_	_	_
13	recognized	recognize	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
14	by	by	ADP	IN	_	_	_	_	_
15	mAb	mAb	PROPN	NNP	Number=Sing	_	_	_	_
16	J393	J393	NUM	CD	NumType=Card	_	_	_	_
17	and	and	CCONJ	CC	_	_	_	_	_
18	mAb	mAb	PROPN	NNP	Number=Sing	_	_	_	_
19	G10	G10	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
20	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
21	2	2	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
22	,	,	PUNCT	,	_	_	_	_	_
23	respectively	respectively	ADV	RB	_	_	_	_	SpaceAfter=No
24	,	,	PUNCT	,	_	_	_	_	_
25	only	only	ADV	RB	_	_	_	_	_
26	J393/CD43	J393/CD43	NUM	CD	NumType=Card	_	_	_	_
27	signaled	signale	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
28	apoptosis	apoptosis	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
29	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2749
# text = J393/CD43 was found to be hyposialylated, bearing predominantly O-linked monosaccharide glycans, whereas G10-2/CD43 bore complex sialylated tetra- and hexasaccharide chains.
1	J393/CD43	J393/CD43	NOUN	NN	Number=Sing	_	_	_	_
2	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
3	found	find	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
4	to	to	PART	TO	_	_	_	_	_
5	be	be	AUX	VB	VerbForm=Inf	_	_	_	_
6	hyposialylated	hyposialylate	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	SpaceAfter=No
7	,	,	PUNCT	,	_	_	_	_	_
8	bearing	bear	VERB	VBG	VerbForm=Ger	_	_	_	_
9	predominantly	predominantly	ADV	RB	_	_	_	_	_
10	O-	O-	PUNCT	:	_	_	_	_	SpaceAfter=No
11	linked	link	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
12	monosaccharide	monosaccharide	NOUN	NN	Number=Sing	_	_	_	_
13	glycans	glycan	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
14	,	,	PUNCT	,	_	_	_	_	_
15	whereas	whereas	SCONJ	IN	_	_	_	_	_
16	G10-2/CD43	G10-2/CD43	NUM	CD	NumType=Card	_	_	_	_
17	bore	bore	NOUN	NN	Number=Sing	_	_	_	_
18	complex	complex	SYM	SYM	_	_	_	_	_
19	sialylated	sialylate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
20	tetra	tetra	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
21	-	-	PUNCT	,	_	_	_	_	_
22	and	and	CCONJ	CC	_	_	_	_	_
23	hexasaccharide	hexasaccharide	NOUN	NN	Number=Sing	_	_	_	_
24	chains	chain	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
25	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2750
# text = Treatment with soluble, bivalent mAb J393 killed 25-50% of the cell population, while concomitant engagement of either the CD3.TcR complex or the integrins CD18 and CD29 significantly potentiated this effect.
1	Treatment	treatment	NOUN	NN	Number=Sing	_	_	_	_
2	with	with	ADP	IN	_	_	_	_	_
3	soluble	soluble	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
4	,	,	PUNCT	,	_	_	_	_	_
5	bivalent	bivalent	ADJ	JJ	Degree=Pos	_	_	_	_
6	mAb	mAb	PROPN	NNP	Number=Sing	_	_	_	_
7	J393	J393	NUM	CD	NumType=Card	_	_	_	_
8	killed	kill	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
9	25	25	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
10	-	-	SYM	SYM	_	_	_	_	SpaceAfter=No
11	50	50	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
12	%	%	SYM	NN	Number=Sing	_	_	_	_
13	of	of	ADP	IN	_	_	_	_	_
14	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
15	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
16	population	population	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
17	,	,	PUNCT	,	_	_	_	_	_
18	while	while	SCONJ	IN	_	_	_	_	_
19	concomitant	concomitant	ADJ	JJ	Degree=Pos	_	_	_	_
20	engagement	engagement	NOUN	NN	Number=Sing	_	_	_	_
21	of	of	ADP	IN	_	_	_	_	_
22	either	either	CCONJ	CC	_	_	_	_	_
23	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
24	CD3.TcR	Cd3.tcr	NOUN	NN	Number=Sing	_	_	_	_
25	complex	complex	NOUN	NN	Number=Sing	_	_	_	_
26	or	or	CCONJ	CC	_	_	_	_	_
27	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
28	integrins	integrin	PROPN	NNPS	Number=Plur	_	_	_	_
29	CD18	CD18	PROPN	NNP	Number=Sing	_	_	_	_
30	and	and	CCONJ	CC	_	_	_	_	_
31	CD29	CD29	PROPN	NNP	Number=Sing	_	_	_	_
32	significantly	significantly	ADV	RB	_	_	_	_	_
33	potentiated	potentiate	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
34	this	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
35	effect	effect	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
36	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2751
# text = Treatment of Jurkat cells with mAb J393 induced tyrosine phosphorylation of specific protein substrates that underwent hyperphosphorylation upon antigen receptor costimulation.
1	Treatment	treatment	NOUN	NN	Number=Sing	_	_	_	_
2	of	of	ADP	IN	_	_	_	_	_
3	Jurkat	Jurkat	PROPN	NNP	Number=Sing	_	_	_	_
4	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
5	with	with	ADP	IN	_	_	_	_	_
6	mAb	mAb	PROPN	NNP	Number=Sing	_	_	_	_
7	J393	J393	NUM	CD	NumType=Card	_	_	_	_
8	induced	induce	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
9	tyrosine	tyrosine	NOUN	NN	Number=Sing	_	_	_	_
10	phosphorylation	phosphorylation	NOUN	NN	Number=Sing	_	_	_	_
11	of	of	ADP	IN	_	_	_	_	_
12	specific	specific	ADJ	JJ	Degree=Pos	_	_	_	_
13	protein	protein	NOUN	NN	Number=Sing	_	_	_	_
14	substrates	substrate	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
15	that	that	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
16	underwent	underwent	ADJ	JJ	Degree=Pos	_	_	_	_
17	hyperphosphorylation	hyperphosphorylation	NOUN	NN	Number=Sing	_	_	_	_
18	upon	upon	ADP	IN	_	_	_	_	_
19	antigen	antigen	ADJ	JJ	Degree=Pos	_	_	_	_
20	receptor	receptor	NOUN	NN	Number=Sing	_	_	_	_
21	costimulation	costimulation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
22	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2752
# text = Tyrosine kinase inhibition by herbimycin A diminished J393/CD43-mediated apoptosis, whereas inhibition of phosphotyrosine phosphatase activity by bis(maltolato)oxovanadium-IV enhanced cell death.
1	Tyrosine	Tyrosine	NOUN	NN	Number=Sing	_	_	_	_
2	kinase	kinase	NOUN	NN	Number=Sing	_	_	_	_
3	inhibition	inhibition	NOUN	NN	Number=Sing	_	_	_	_
4	by	by	ADP	IN	_	_	_	_	_
5	herbimycin	herbimycin	NOUN	NN	Number=Sing	_	_	_	_
6	A	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
7	diminished	diminish	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
8	J393/CD43	J393/CD43	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
9	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
10	mediated	mediate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
11	apoptosis	apoptosis	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
12	,	,	PUNCT	,	_	_	_	_	_
13	whereas	whereas	SCONJ	IN	_	_	_	_	_
14	inhibition	inhibition	NOUN	NN	Number=Sing	_	_	_	_
15	of	of	ADP	IN	_	_	_	_	_
16	phosphotyrosine	phosphotyrosine	NOUN	NN	Number=Sing	_	_	_	_
17	phosphatase	phosphatase	NOUN	NN	Number=Sing	_	_	_	_
18	activity	activity	NOUN	NN	Number=Sing	_	_	_	_
19	by	by	ADP	IN	_	_	_	_	_
20	bis	bis	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
21	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
22	maltolato	maltolato	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
23	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
24	oxovanadium	oxovanadium	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
25	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
26	IV	iv	NOUN	NN	Number=Sing	_	_	_	_
27	enhanced	enhance	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
28	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
29	death	death	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
30	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2753
# text = Signal transduction through tyrosine kinase activation may lead to altered gene expression, as J393/CD43 ligation prompted decreases in the nuclear localization of the transcriptional regulatory protein NF-kappaB and proteins binding the interferon-inducible regulatory element.
1	Signal	signal	ADJ	JJ	Degree=Pos	_	_	_	_
2	transduction	transduction	NOUN	NN	Number=Sing	_	_	_	_
3	through	through	ADP	IN	_	_	_	_	_
4	tyrosine	tyrosine	NOUN	NN	Number=Sing	_	_	_	_
5	kinase	kinase	NOUN	NN	Number=Sing	_	_	_	_
6	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
7	may	may	AUX	MD	VerbForm=Fin	_	_	_	_
8	lead	lead	VERB	VB	VerbForm=Inf	_	_	_	_
9	to	to	ADP	IN	_	_	_	_	_
10	altered	alter	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
11	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
12	expression	expression	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
13	,	,	PUNCT	,	_	_	_	_	_
14	as	as	SCONJ	IN	_	_	_	_	_
15	J393/CD43	J393/CD43	NUM	CD	NumType=Card	_	_	_	_
16	ligation	ligation	NOUN	NN	Number=Sing	_	_	_	_
17	prompted	prompt	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
18	decreases	decrease	NOUN	NNS	Number=Plur	_	_	_	_
19	in	in	ADP	IN	_	_	_	_	_
20	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
21	nuclear	nuclear	ADJ	JJ	Degree=Pos	_	_	_	_
22	localization	localization	NOUN	NN	Number=Sing	_	_	_	_
23	of	of	ADP	IN	_	_	_	_	_
24	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
25	transcriptional	transcriptional	ADJ	JJ	Degree=Pos	_	_	_	_
26	regulatory	regulatory	ADJ	JJ	Degree=Pos	_	_	_	_
27	protein	protein	NOUN	NN	Number=Sing	_	_	_	_
28	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
29	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
30	kappaB	kappaB	PROPN	NNP	Number=Sing	_	_	_	_
31	and	and	CCONJ	CC	_	_	_	_	_
32	proteins	protein	NOUN	NNS	Number=Plur	_	_	_	_
33	binding	bind	VERB	VBG	VerbForm=Ger	_	_	_	_
34	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
35	interferon	interferon	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
36	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
37	inducible	inducible	ADJ	JJ	Degree=Pos	_	_	_	_
38	regulatory	regulatory	ADJ	JJ	Degree=Pos	_	_	_	_
39	element	element	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
40	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2754
# text = Since peripheral blood T-lymphocytes express cryptic epitopes for mAb J393, these findings demonstrate the existence of a tightly regulated CD43-mediated pathway for inducing apoptosis in human T-cell lineages.
1	Since	since	ADP	IN	_	_	_	_	_
2	peripheral	peripheral	ADJ	JJ	Degree=Pos	_	_	_	_
3	blood	blood	NOUN	NN	Number=Sing	_	_	_	_
4	T-	T-	PUNCT	:	_	_	_	_	SpaceAfter=No
5	lymphocytes	lymphocyte	NOUN	NNS	Number=Plur	_	_	_	_
6	express	express	ADJ	JJ	Degree=Pos	_	_	_	_
7	cryptic	cryptic	ADJ	JJ	Degree=Pos	_	_	_	_
8	epitopes	epitope	NOUN	NNS	Number=Plur	_	_	_	_
9	for	for	ADP	IN	_	_	_	_	_
10	mAb	mAb	PROPN	NNP	Number=Sing	_	_	_	_
11	J393	J393	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
12	,	,	PUNCT	,	_	_	_	_	_
13	these	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
14	findings	finding	NOUN	NNS	Number=Plur	_	_	_	_
15	demonstrate	demonstrate	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
16	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
17	existence	existence	NOUN	NN	Number=Sing	_	_	_	_
18	of	of	ADP	IN	_	_	_	_	_
19	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
20	tightly	tightly	ADV	RB	_	_	_	_	_
21	regulated	regulate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
22	CD43	CD43	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
23	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
24	mediated	mediate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
25	pathway	pathway	NOUN	NN	Number=Sing	_	_	_	_
26	for	for	SCONJ	IN	_	_	_	_	_
27	inducing	induce	VERB	VBG	VerbForm=Ger	_	_	_	_
28	apoptosis	apoptosis	NOUN	NN	Number=Sing	_	_	_	_
29	in	in	ADP	IN	_	_	_	_	_
30	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
31	T-	t-	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
32	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
33	lineages	lineage	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
34	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 2755
# text = Document 003003307 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	003003307	003003307	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 2756
# text = 1,25-Dihydroxyvitamin D3 induces differentiation of a retinoic acid-resistant acute promyelocytic leukemia cell line (UF-1) associated with expression of p21(WAF1/CIP1) and p27(KIP1).
1	1,25	1,25	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
2	-	-	PUNCT	:	_	_	_	_	SpaceAfter=No
3	Dihydroxyvitamin	Dihydroxyvitamin	NOUN	NN	Number=Sing	_	_	_	_
4	D3	D3	NUM	CD	NumType=Card	_	_	_	_
5	induces	induce	NOUN	NNS	Number=Plur	_	_	_	_
6	differentiation	differentiation	NOUN	NN	Number=Sing	_	_	_	_
7	of	of	ADP	IN	_	_	_	_	_
8	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
9	retinoic	retinoic	ADJ	JJ	Degree=Pos	_	_	_	_
10	acid	acid	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
11	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
12	resistant	resistant	NOUN	NN	Number=Sing	_	_	_	_
13	acute	acute	NOUN	NN	Number=Sing	_	_	_	_
14	promyelocytic	promyelocytic	ADJ	JJ	Degree=Pos	_	_	_	_
15	leukemia	leukemia	NOUN	NN	Number=Sing	_	_	_	_
16	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
17	line	line	NOUN	NN	Number=Sing	_	_	_	_
18	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
19	UF	UF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
20	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
21	1	1	X	LS	_	_	_	_	SpaceAfter=No
22	)	)	PUNCT	-RRB-	_	_	_	_	_
23	associated	associate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
24	with	with	ADP	IN	_	_	_	_	_
25	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
26	of	of	ADP	IN	_	_	_	_	_
27	p21	p21	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
28	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
29	WAF1/CIP1	WAF1/CIP1	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
30	)	)	PUNCT	-RRB-	_	_	_	_	_
31	and	and	CCONJ	CC	_	_	_	_	_
32	p27	p27	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
33	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
34	KIP1	KIP1	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
35	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
36	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 2757
# text = Retinoic acid (RA) resistance is a serious problem for patients with acute promyelocytic leukemia (APL) who are receiving all-trans RA.
1	Retinoic	Retinoic	ADJ	JJ	Degree=Pos	_	_	_	_
2	acid	acid	NOUN	NN	Number=Sing	_	_	_	_
3	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
4	RA	RA	X	AFX	_	_	_	_	SpaceAfter=No
5	)	)	PUNCT	-RRB-	_	_	_	_	_
6	resistance	resistance	NOUN	NN	Number=Sing	_	_	_	_
7	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
8	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
9	serious	serious	ADJ	JJ	Degree=Pos	_	_	_	_
10	problem	problem	NOUN	NN	Number=Sing	_	_	_	_
11	for	for	ADP	IN	_	_	_	_	_
12	patients	patient	NOUN	NNS	Number=Plur	_	_	_	_
13	with	with	ADP	IN	_	_	_	_	_
14	acute	acute	ADJ	JJ	Degree=Pos	_	_	_	_
15	promyelocytic	promyelocytic	ADJ	JJ	Degree=Pos	_	_	_	_
16	leukemia	leukemia	NOUN	NN	Number=Sing	_	_	_	_
17	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
18	APL	APL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
19	)	)	PUNCT	-RRB-	_	_	_	_	_
20	who	who	PRON	WP	PronType=Rel	_	_	_	_
21	are	be	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
22	receiving	receive	VERB	VBG	Tense=Pres|VerbForm=Part	_	_	_	_
23	all	all	DET	DT	_	_	_	_	SpaceAfter=No
24	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
25	trans	tran	NOUN	NNS	Number=Plur	_	_	_	_
26	RA	RA	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
27	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2758
# text = However, the mechanisms and strategies to overcome RA resistance by APL cells are still unclear.
1	However	however	ADV	RB	_	_	_	_	SpaceAfter=No
2	,	,	PUNCT	,	_	_	_	_	_
3	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
4	mechanisms	mechanism	NOUN	NNS	Number=Plur	_	_	_	_
5	and	and	CCONJ	CC	_	_	_	_	_
6	strategies	strategy	NOUN	NNS	Number=Plur	_	_	_	_
7	to	to	PART	TO	_	_	_	_	_
8	overcome	overcome	VERB	VB	VerbForm=Inf	_	_	_	_
9	RA	RA	PROPN	NNP	Number=Sing	_	_	_	_
10	resistance	resistance	NOUN	NN	Number=Sing	_	_	_	_
11	by	by	ADP	IN	_	_	_	_	_
12	APL	Apl	ADJ	JJ	Degree=Pos	_	_	_	_
13	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
14	are	be	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
15	still	still	ADV	RB	_	_	_	_	_
16	unclear	unclear	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
17	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2759
# text = The biologic effects of RA are mediated by two distinct families of transcriptional factors:
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	biologic	biologic	NOUN	NN	Number=Sing	_	_	_	_
3	effects	effect	NOUN	NNS	Number=Plur	_	_	_	_
4	of	of	ADP	IN	_	_	_	_	_
5	RA	Ra	NOUN	NN	Number=Sing	_	_	_	_
6	are	be	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
7	mediated	mediate	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
8	by	by	ADP	IN	_	_	_	_	_
9	two	two	NUM	CD	NumType=Card	_	_	_	_
10	distinct	distinct	ADJ	JJ	Degree=Pos	_	_	_	_
11	families	family	NOUN	NNS	Number=Plur	_	_	_	_
12	of	of	ADP	IN	_	_	_	_	_
13	transcriptional	transcriptional	ADJ	JJ	Degree=Pos	_	_	_	_
14	factors	factor	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
15	:	:	PUNCT	:	_	_	_	_	_

# sent_id = 2760
# text = RA receptors (RARs) and retinoid X receptors (RXRs).
1	RA	Ra	NOUN	NN	Number=Sing	_	_	_	_
2	receptors	receptor	NOUN	NNS	Number=Plur	_	_	_	_
3	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
4	RARs	RAR	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
5	)	)	PUNCT	-RRB-	_	_	_	_	_
6	and	and	CCONJ	CC	_	_	_	_	_
7	retinoid	retinoid	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
8	X	x	ADJ	JJ	Degree=Pos	_	_	_	_
9	receptors	receptor	NOUN	NNS	Number=Plur	_	_	_	_
10	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
11	RXRs	RXR	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
12	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
13	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2761
# text = RXRs heterodimerize with 1, 25-dihydroxyvitamin D3 [1,25(OH)2D3] receptor (VDR), enabling their efficient transcriptional activation.
1	RXRs	RXR	NOUN	NNS	Number=Plur	_	_	_	_
2	heterodimerize	heterodimerize	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
3	with	with	ADP	IN	_	_	_	_	_
4	1	1	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
5	,	,	PUNCT	,	_	_	_	_	_
6	25	25	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
7	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
8	dihydroxyvitamin	dihydroxyvitamin	NOUN	NN	Number=Sing	_	_	_	_
9	D3	D3	NOUN	NN	Number=Sing	_	_	_	_
10	[	[	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
11	1,25	1,25	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
12	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
13	OH	oh	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
14	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
15	2D3	2D3	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
16	]	]	PUNCT	-RRB-	_	_	_	_	_
17	receptor	receptor	NOUN	NN	Number=Sing	_	_	_	_
18	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
19	VDR	VDR	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
20	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
21	,	,	PUNCT	,	_	_	_	_	_
22	enabling	enable	VERB	VBG	VerbForm=Ger	_	_	_	_
23	their	they	PRON	PRP$	Number=Plur|Person=3|Poss=Yes|PronType=Prs	_	_	_	_
24	efficient	efficient	ADJ	JJ	Degree=Pos	_	_	_	_
25	transcriptional	transcriptional	ADJ	JJ	Degree=Pos	_	_	_	_
26	activation	activation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
27	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2762
# text = The cyclin-dependent kinase (cdk) inhibitor p21(WAF1/CIP1) has a vitamin D3-responsive element (VDRE) in its promoter, and 1,25(OH)2D3 enhances the expression of p21(WAF1/CIP1) and induces differentiation of selected myeloid leukemic cell lines.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	cyclin	cyclin	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
3	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
4	dependent	dependent	ADJ	JJ	Degree=Pos	_	_	_	_
5	kinase	kinase	NOUN	NN	Number=Sing	_	_	_	_
6	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
7	cdk	cdk	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
8	)	)	PUNCT	-RRB-	_	_	_	_	_
9	inhibitor	inhibitor	NOUN	NN	Number=Sing	_	_	_	_
10	p21	p21	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
11	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
12	WAF1/CIP1	Waf1/cip1	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
13	)	)	PUNCT	-RRB-	_	_	_	_	_
14	has	have	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
15	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
16	vitamin	vitamin	NOUN	NN	Number=Sing	_	_	_	_
17	D3	D3	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
18	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
19	responsive	responsive	ADJ	JJ	Degree=Pos	_	_	_	_
20	element	element	NOUN	NN	Number=Sing	_	_	_	_
21	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
22	VDRE	VDRE	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
23	)	)	PUNCT	-RRB-	_	_	_	_	_
24	in	in	ADP	IN	_	_	_	_	_
25	its	its	PRON	PRP$	Gender=Neut|Number=Sing|Person=3|Poss=Yes|PronType=Prs	_	_	_	_
26	promoter	promoter	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
27	,	,	PUNCT	,	_	_	_	_	_
28	and	and	CCONJ	CC	_	_	_	_	_
29	1,25	1,25	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
30	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
31	OH	Oh	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
32	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
33	2D3	2D3	NUM	CD	NumType=Card	_	_	_	_
34	enhances	enhance	NOUN	NNS	Number=Plur	_	_	_	_
35	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
36	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
37	of	of	ADP	IN	_	_	_	_	_
38	p21	p21	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
39	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
40	WAF1/CIP1	Waf1/cip1	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
41	)	)	PUNCT	-RRB-	_	_	_	_	_
42	and	and	CCONJ	CC	_	_	_	_	_
43	induces	induce	NOUN	NNS	Number=Plur	_	_	_	_
44	differentiation	differentiation	NOUN	NN	Number=Sing	_	_	_	_
45	of	of	ADP	IN	_	_	_	_	_
46	selected	selected	ADJ	JJ	Degree=Pos	_	_	_	_
47	myeloid	myeloid	NOUN	NN	Number=Sing	_	_	_	_
48	leukemic	leukemic	ADJ	JJ	Degree=Pos	_	_	_	_
49	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
50	lines	line	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
51	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2763
# text = We have recently established a novel APL cell line (UF-1) with features of RA resistance.
1	We	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
2	have	have	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
3	recently	recently	ADV	RB	_	_	_	_	_
4	established	establish	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
5	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
6	novel	novel	NOUN	NN	Number=Sing	_	_	_	_
7	APL	Apl	NOUN	NN	Number=Sing	_	_	_	_
8	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
9	line	line	NOUN	NN	Number=Sing	_	_	_	_
10	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
11	UF	UF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
12	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
13	1	1	X	LS	_	_	_	_	SpaceAfter=No
14	)	)	PUNCT	-RRB-	_	_	_	_	_
15	with	with	ADP	IN	_	_	_	_	_
16	features	feature	NOUN	NNS	Number=Plur	_	_	_	_
17	of	of	ADP	IN	_	_	_	_	_
18	RA	RA	PROPN	NNP	Number=Sing	_	_	_	_
19	resistance	resistance	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
20	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2764
# text = 1,25(OH)2D3 can induce growth inhibition and G1 arrest of UF-1 cells, resulting in differentiation of these cells toward granulocytes.
1	1,25	1,25	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
2	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
3	OH	oh	INTJ	UH	_	_	_	_	SpaceAfter=No
4	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
5	2D3	2D3	NOUN	NN	Number=Sing	_	_	_	_
6	can	can	AUX	MD	VerbForm=Fin	_	_	_	_
7	induce	induce	VERB	VB	VerbForm=Inf	_	_	_	_
8	growth	growth	NOUN	NN	Number=Sing	_	_	_	_
9	inhibition	inhibition	NOUN	NN	Number=Sing	_	_	_	_
10	and	and	CCONJ	CC	_	_	_	_	_
11	G1	G1	NUM	CD	NumType=Card	_	_	_	_
12	arrest	arrest	NOUN	NN	Number=Sing	_	_	_	_
13	of	of	ADP	IN	_	_	_	_	_
14	UF	UF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
15	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
16	1	1	NUM	CD	NumType=Card	_	_	_	_
17	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
18	,	,	PUNCT	,	_	_	_	_	_
19	resulting	result	VERB	VBG	VerbForm=Ger	_	_	_	_
20	in	in	ADP	IN	_	_	_	_	_
21	differentiation	differentiation	NOUN	NN	Number=Sing	_	_	_	_
22	of	of	ADP	IN	_	_	_	_	_
23	these	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
24	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
25	toward	toward	ADP	IN	_	_	_	_	_
26	granulocytes	granulocyte	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
27	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2765
# text = This 1, 25(OH)2D3-induced G1 arrest is enhanced by all-trans RA.
1	This	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
2	1	1	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
3	,	,	PUNCT	,	_	_	_	_	_
4	25	25	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
5	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
6	OH	Oh	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
7	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
8	2D3	2D3	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
9	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
10	induced	induce	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
11	G1	g1	NOUN	NN	Number=Sing	_	_	_	_
12	arrest	arrest	NOUN	NN	Number=Sing	_	_	_	_
13	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
14	enhanced	enhance	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
15	by	by	ADP	IN	_	_	_	_	_
16	all	all	DET	DT	_	_	_	_	SpaceAfter=No
17	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
18	trans	tran	NOUN	NNS	Number=Plur	_	_	_	_
19	RA	Ra	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
20	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2766
# text = Also, 1, 25(OH)2D3 (10(-10) to 10(-7) mol/L) in combination with RA markedly inhibits cellular proliferation in a dose- and time-dependent manner.
1	Also	also	ADV	RB	_	_	_	_	SpaceAfter=No
2	,	,	PUNCT	,	_	_	_	_	_
3	1	1	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
4	,	,	PUNCT	,	_	_	_	_	_
5	25	25	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
6	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
7	OH	Oh	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
8	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
9	2D3	2D3	NUM	CD	NumType=Card	_	_	_	_
10	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
11	10	10	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
12	(-10	(-10	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
13	)	)	PUNCT	-RRB-	_	_	_	_	_
14	to	to	ADP	IN	_	_	_	_	_
15	10	10	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
16	(-	(-	PUNCT	.	_	_	_	_	SpaceAfter=No
17	7	7	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
18	)	)	PUNCT	-RRB-	_	_	_	_	_
19	mol/L	mol/l	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
20	)	)	PUNCT	-RRB-	_	_	_	_	_
21	in	in	ADP	IN	_	_	_	_	_
22	combination	combination	NOUN	NN	Number=Sing	_	_	_	_
23	with	with	ADP	IN	_	_	_	_	_
24	RA	RA	PROPN	NNP	Number=Sing	_	_	_	_
25	markedly	markedly	ADV	RB	_	_	_	_	_
26	inhibits	inhibit	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
27	cellular	cellular	ADJ	JJ	Degree=Pos	_	_	_	_
28	proliferation	proliferation	NOUN	NN	Number=Sing	_	_	_	_
29	in	in	ADP	IN	_	_	_	_	_
30	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
31	dose	dose	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
32	-	-	PUNCT	,	_	_	_	_	_
33	and	and	CCONJ	CC	_	_	_	_	_
34	time	time	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
35	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
36	dependent	dependent	ADJ	JJ	Degree=Pos	_	_	_	_
37	manner	manner	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
38	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2767
# text = Associated with these findings, the levels of p21(WAF1/CIP1) and p27(KIP1) mRNA and protein increased in these cells.
1	Associated	Associated	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
2	with	with	ADP	IN	_	_	_	_	_
3	these	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
4	findings	findings	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
5	,	,	PUNCT	,	_	_	_	_	_
6	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
7	levels	level	NOUN	NNS	Number=Plur	_	_	_	_
8	of	of	ADP	IN	_	_	_	_	_
9	p21	p21	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
10	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
11	WAF1/CIP1	WAF1/CIP1	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
12	)	)	PUNCT	-RRB-	_	_	_	_	_
13	and	and	CCONJ	CC	_	_	_	_	_
14	p27	p27	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
15	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
16	KIP1	KIP1	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
17	)	)	PUNCT	-RRB-	_	_	_	_	_
18	mRNA	mRNa	NOUN	NN	Number=Sing	_	_	_	_
19	and	and	CCONJ	CC	_	_	_	_	_
20	protein	protein	NOUN	NN	Number=Sing	_	_	_	_
21	increased	increase	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
22	in	in	ADP	IN	_	_	_	_	_
23	these	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
24	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
25	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2768
# text = Northern blot analysis showed that p21(WAF1/CIP1) and p27(KIP1) mRNA and protein increased in these cells.
1	Northern	Northern	ADJ	JJ	Degree=Pos	_	_	_	_
2	blot	blot	NOUN	NN	Number=Sing	_	_	_	_
3	analysis	analysis	NOUN	NN	Number=Sing	_	_	_	_
4	showed	show	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
5	that	that	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
6	p21	p21	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
7	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
8	WAF1/CIP1	WAF1/CIP1	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
9	)	)	PUNCT	-RRB-	_	_	_	_	_
10	and	and	CCONJ	CC	_	_	_	_	_
11	p27	p27	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
12	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
13	KIP1	KIP1	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
14	)	)	PUNCT	-RRB-	_	_	_	_	_
15	mRNA	mRNa	NOUN	NN	Number=Sing	_	_	_	_
16	and	and	CCONJ	CC	_	_	_	_	_
17	protein	protein	NOUN	NN	Number=Sing	_	_	_	_
18	increased	increase	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
19	in	in	ADP	IN	_	_	_	_	_
20	these	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
21	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
22	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2769
# text = Northern blot analysis showed that p21(WAF1/CIP1) and p27(KIP1) transcripts were induced after 6 hours' exposure to 1,25(OH)2D3 and then decreased to basal levels over 48 hours.
1	Northern	Northern	ADJ	JJ	Degree=Pos	_	_	_	_
2	blot	blot	NOUN	NN	Number=Sing	_	_	_	_
3	analysis	analysis	NOUN	NN	Number=Sing	_	_	_	_
4	showed	show	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
5	that	that	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
6	p21	p21	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
7	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
8	WAF1/CIP1	WAF1/CIP1	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
9	)	)	PUNCT	-RRB-	_	_	_	_	_
10	and	and	CCONJ	CC	_	_	_	_	_
11	p27	p27	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
12	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
13	KIP1	KIP1	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
14	)	)	PUNCT	-RRB-	_	_	_	_	_
15	transcripts	transcript	NOUN	NNS	Number=Plur	_	_	_	_
16	were	be	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
17	induced	induce	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
18	after	after	ADP	IN	_	_	_	_	_
19	6	6	NUM	CD	NumType=Card	_	_	_	_
20	hours	hour	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
21	'	's	PART	POS	_	_	_	_	_
22	exposure	exposure	NOUN	NN	Number=Sing	_	_	_	_
23	to	to	ADP	IN	_	_	_	_	_
24	1,25	1,25	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
25	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
26	OH	oh	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
27	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
28	2D3	2D3	NUM	CD	NumType=Card	_	_	_	_
29	and	and	CCONJ	CC	_	_	_	_	_
30	then	then	ADV	RB	PronType=Dem	_	_	_	_
31	decreased	decrease	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
32	to	to	ADP	IN	_	_	_	_	_
33	basal	basal	ADJ	JJ	Degree=Pos	_	_	_	_
34	levels	level	NOUN	NNS	Number=Plur	_	_	_	_
35	over	over	ADP	IN	_	_	_	_	_
36	48	48	NUM	CD	NumType=Card	_	_	_	_
37	hours	hour	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
38	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2770
# text = Western blot experiments showed that p21(WAF1/CIP1) protein levels increased and became detectable after 12 hours of 1,25(OH)2D3 treatment and induction of p27(KIP1) protein was much more gradual and sustained in UF-1 cells.
1	Western	western	ADJ	JJ	Degree=Pos	_	_	_	_
2	blot	blot	NOUN	NN	Number=Sing	_	_	_	_
3	experiments	experiment	NOUN	NNS	Number=Plur	_	_	_	_
4	showed	show	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
5	that	that	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
6	p21	p21	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
7	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
8	WAF1/CIP1	WAF1/CIP1	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
9	)	)	PUNCT	-RRB-	_	_	_	_	_
10	protein	protein	NOUN	NN	Number=Sing	_	_	_	_
11	levels	level	NOUN	NNS	Number=Plur	_	_	_	_
12	increased	increase	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
13	and	and	CCONJ	CC	_	_	_	_	_
14	became	become	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
15	detectable	detectable	ADJ	JJ	Degree=Pos	_	_	_	_
16	after	after	ADP	IN	_	_	_	_	_
17	12	12	NUM	CD	NumType=Card	_	_	_	_
18	hours	hour	NOUN	NNS	Number=Plur	_	_	_	_
19	of	of	ADP	IN	_	_	_	_	_
20	1,25	1,25	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
21	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
22	OH	oh	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
23	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
24	2D3	2D3	NUM	CD	NumType=Card	_	_	_	_
25	treatment	treatment	NOUN	NN	Number=Sing	_	_	_	_
26	and	and	CCONJ	CC	_	_	_	_	_
27	induction	induction	NOUN	NN	Number=Sing	_	_	_	_
28	of	of	ADP	IN	_	_	_	_	_
29	p27	p27	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
30	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
31	KIP1	KIP1	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
32	)	)	PUNCT	-RRB-	_	_	_	_	_
33	protein	protein	NOUN	NN	Number=Sing	_	_	_	_
34	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
35	much	much	ADV	RB	_	_	_	_	_
36	more	more	ADJ	JJR	Degree=Cmp	_	_	_	_
37	gradual	gradual	NOUN	NN	Number=Sing	_	_	_	_
38	and	and	CCONJ	CC	_	_	_	_	_
39	sustained	sustain	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
40	in	in	ADP	IN	_	_	_	_	_
41	UF	UF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
42	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
43	1	1	NUM	CD	NumType=Card	_	_	_	_
44	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
45	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2771
# text = Interestingly, the combination of 1, 25(OH)2D3 and RA markedly enhanced the levels of p27(KIP1) transcript and protein as compared with levels induced by 1, 25(OH)2D3 alone.
1	Interestingly	Interestingly	ADV	RB	_	_	_	_	SpaceAfter=No
2	,	,	PUNCT	,	_	_	_	_	_
3	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
4	combination	combination	NOUN	NN	Number=Sing	_	_	_	_
5	of	of	ADP	IN	_	_	_	_	_
6	1	1	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
7	,	,	PUNCT	,	_	_	_	_	_
8	25	25	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
9	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
10	OH	Oh	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
11	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
12	2D3	2D3	NUM	CD	NumType=Card	_	_	_	_
13	and	and	CCONJ	CC	_	_	_	_	_
14	RA	RA	PROPN	NNP	Number=Sing	_	_	_	_
15	markedly	markedly	ADV	RB	_	_	_	_	_
16	enhanced	enhance	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
17	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
18	levels	level	NOUN	NNS	Number=Plur	_	_	_	_
19	of	of	ADP	IN	_	_	_	_	_
20	p27	p27	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
21	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
22	KIP1	KIP1	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
23	)	)	PUNCT	-RRB-	_	_	_	_	_
24	transcript	transcript	NOUN	NN	Number=Sing	_	_	_	_
25	and	and	CCONJ	CC	_	_	_	_	_
26	protein	protein	NOUN	NN	Number=Sing	_	_	_	_
27	as	as	SCONJ	IN	_	_	_	_	_
28	compared	compare	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
29	with	with	ADP	IN	_	_	_	_	_
30	levels	level	NOUN	NNS	Number=Plur	_	_	_	_
31	induced	induce	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
32	by	by	ADP	IN	_	_	_	_	_
33	1	1	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
34	,	,	PUNCT	,	_	_	_	_	_
35	25	25	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
36	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
37	OH	Oh	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
38	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
39	2D3	2D3	NUM	CD	NumType=Card	_	_	_	_
40	alone	alone	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
41	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2772
# text = In addition, exogenous p27(KIP1) expression can enhance the level of CD11b antigen in myeloid leukemic cells.
1	In	in	ADP	IN	_	_	_	_	_
2	addition	addition	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
3	,	,	PUNCT	,	_	_	_	_	_
4	exogenous	exogenous	ADJ	JJ	Degree=Pos	_	_	_	_
5	p27	p27	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
6	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
7	KIP1	KIP1	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
8	)	)	PUNCT	-RRB-	_	_	_	_	_
9	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
10	can	can	AUX	MD	VerbForm=Fin	_	_	_	_
11	enhance	enhance	VERB	VB	VerbForm=Inf	_	_	_	_
12	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
13	level	level	NOUN	NN	Number=Sing	_	_	_	_
14	of	of	ADP	IN	_	_	_	_	_
15	CD	CD	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
16	11	11	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
17	b	b	NOUN	NN	Number=Sing	_	_	_	_
18	antigen	antigen	NOUN	NNS	Number=Plur	_	_	_	_
19	in	in	ADP	IN	_	_	_	_	_
20	myeloid	myeloid	ADJ	JJ	Degree=Pos	_	_	_	_
21	leukemic	leukemic	ADJ	JJ	Degree=Pos	_	_	_	_
22	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
23	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2773
# text = In contrast, RA alone can induce G1 arrest of UF-1 cells; however, it did not result in an increase of p21(WAF1/CIP1) and p27(KIP1) transcript and protein expression in RA-resistant cells.
1	In	in	ADP	IN	_	_	_	_	_
2	contrast	contrast	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
3	,	,	PUNCT	,	_	_	_	_	_
4	RA	RA	PROPN	NNP	Number=Sing	_	_	_	_
5	alone	alone	ADV	RB	_	_	_	_	_
6	can	can	AUX	MD	VerbForm=Fin	_	_	_	_
7	induce	induce	VERB	VB	VerbForm=Inf	_	_	_	_
8	G1	G1	NUM	CD	NumType=Card	_	_	_	_
9	arrest	arrest	NOUN	NN	Number=Sing	_	_	_	_
10	of	of	ADP	IN	_	_	_	_	_
11	UF	UF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
12	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
13	1	1	NUM	CD	NumType=Card	_	_	_	_
14	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
15	;	;	PUNCT	,	_	_	_	_	_
16	however	however	ADV	RB	_	_	_	_	SpaceAfter=No
17	,	,	PUNCT	,	_	_	_	_	_
18	it	it	PRON	PRP	Case=Nom|Gender=Neut|Number=Sing|Person=3|PronType=Prs	_	_	_	_
19	did	do	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
20	not	not	PART	RB	_	_	_	_	_
21	result	result	VERB	VB	VerbForm=Inf	_	_	_	_
22	in	in	ADP	IN	_	_	_	_	_
23	an	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
24	increase	increase	NOUN	NN	Number=Sing	_	_	_	_
25	of	of	ADP	IN	_	_	_	_	_
26	p21	p21	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
27	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
28	WAF1/CIP1	Waf1/cip1	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
29	)	)	PUNCT	-RRB-	_	_	_	_	_
30	and	and	CCONJ	CC	_	_	_	_	_
31	p27(	p27(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
32	KIP1	KIP1	X	LS	_	_	_	_	SpaceAfter=No
33	)	)	PUNCT	-RRB-	_	_	_	_	_
34	transcript	transcript	NOUN	NN	Number=Sing	_	_	_	_
35	and	and	CCONJ	CC	_	_	_	_	_
36	protein	protein	NOUN	NN	Number=Sing	_	_	_	_
37	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
38	in	in	ADP	IN	_	_	_	_	_
39	RA	RA	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
40	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
41	resistant	resistant	ADJ	JJ	Degree=Pos	_	_	_	_
42	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
43	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2774
# text = Taken together, we conclude that 1,25(OH)2D3 induces increased expression of cdk inhibitors, which mediates a G1 arrest, and this may be associated with differentiation of RA-resistant UF-1 cells toward mature granulocytes.
1	Taken	take	PROPN	NNP	Number=Sing	_	_	_	_
2	together	together	ADV	RB	_	_	_	_	SpaceAfter=No
3	,	,	PUNCT	,	_	_	_	_	_
4	we	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
5	conclude	conclude	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
6	that	that	SCONJ	IN	_	_	_	_	_
7	1,25	1,25	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
8	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
9	OH	Oh	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
10	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
11	2D3	2D3	NUM	CD	NumType=Card	_	_	_	_
12	induces	induce	NOUN	NNS	Number=Plur	_	_	_	_
13	increased	increase	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
14	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
15	of	of	ADP	IN	_	_	_	_	_
16	cdk	cdk	NOUN	NN	Number=Sing	_	_	_	_
17	inhibitors	inhibitor	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
18	,	,	PUNCT	,	_	_	_	_	_
19	which	which	PRON	WDT	PronType=Rel	_	_	_	_
20	mediates	mediate	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
21	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
22	G1	G1	NUM	CD	NumType=Card	_	_	_	_
23	arrest	arrest	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
24	,	,	PUNCT	,	_	_	_	_	_
25	and	and	CCONJ	CC	_	_	_	_	_
26	this	this	PRON	DT	Number=Sing|PronType=Dem	_	_	_	_
27	may	may	AUX	MD	VerbForm=Fin	_	_	_	_
28	be	be	AUX	VB	VerbForm=Inf	_	_	_	_
29	associated	associate	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
30	with	with	ADP	IN	_	_	_	_	_
31	differentiation	differentiation	NOUN	NN	Number=Sing	_	_	_	_
32	of	of	ADP	IN	_	_	_	_	_
33	RA	RA	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
34	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
35	resistant	resistant	NOUN	NN	Number=Sing	_	_	_	_
36	UF	Uf	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
37	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
38	1	1	NUM	CD	NumType=Card	_	_	_	_
39	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
40	toward	toward	ADP	IN	_	_	_	_	_
41	mature	mature	ADJ	JJ	Degree=Pos	_	_	_	_
42	granulocytes	granulocyte	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
43	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 2775
# text = Document 003003314 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	003003314	003003314	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 2776
# text = Effects of interleukin-10 on human peripheral blood mononuclear cell responses to Cryptococcus neoformans, Candida albicans, and lipopolysaccharide.
1	Effects	Effects	NOUN	NNS	Number=Plur	_	_	_	_
2	of	of	ADP	IN	_	_	_	_	_
3	interleukin	interleukin	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
4	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
5	10	10	NUM	CD	NumType=Card	_	_	_	_
6	on	on	ADP	IN	_	_	_	_	_
7	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
8	peripheral	peripheral	ADJ	JJ	Degree=Pos	_	_	_	_
9	blood	blood	NOUN	NN	Number=Sing	_	_	_	_
10	mononuclear	mononuclear	ADJ	JJ	Degree=Pos	_	_	_	_
11	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
12	responses	response	NOUN	NNS	Number=Plur	_	_	_	_
13	to	to	ADP	IN	_	_	_	_	_
14	Cryptococcus	Cryptococcus	PROPN	NNP	Number=Sing	_	_	_	_
15	neoformans	neoforman	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
16	,	,	PUNCT	,	_	_	_	_	_
17	Candida	Candida	PROPN	NNP	Number=Sing	_	_	_	_
18	albicans	albican	PROPN	NNPS	Number=Plur	_	_	_	SpaceAfter=No
19	,	,	PUNCT	,	_	_	_	_	_
20	and	and	CCONJ	CC	_	_	_	_	_
21	lipopolysaccharide	lipopolysaccharide	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
22	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 2777
# text = Deactivation of mononuclear phagocytes is critical to limit the inflammatory response but can be detrimental in the face of progressive infection.
1	Deactivation	Deactivation	NOUN	NN	Number=Sing	_	_	_	_
2	of	of	ADP	IN	_	_	_	_	_
3	mononuclear	mononuclear	ADJ	JJ	Degree=Pos	_	_	_	_
4	phagocytes	phagocyte	NOUN	NNS	Number=Plur	_	_	_	_
5	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
6	critical	critical	ADJ	JJ	Degree=Pos	_	_	_	_
7	to	to	PART	TO	_	_	_	_	_
8	limit	limit	VERB	VB	VerbForm=Inf	_	_	_	_
9	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
10	inflammatory	inflammatory	ADJ	JJ	Degree=Pos	_	_	_	_
11	response	response	NOUN	NN	Number=Sing	_	_	_	_
12	but	but	CCONJ	CC	_	_	_	_	_
13	can	can	AUX	MD	VerbForm=Fin	_	_	_	_
14	be	be	AUX	VB	VerbForm=Inf	_	_	_	_
15	detrimental	detrimental	ADJ	JJ	Degree=Pos	_	_	_	_
16	in	in	ADP	IN	_	_	_	_	_
17	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
18	face	face	NOUN	NN	Number=Sing	_	_	_	_
19	of	of	ADP	IN	_	_	_	_	_
20	progressive	progressive	ADJ	JJ	Degree=Pos	_	_	_	_
21	infection	infection	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
22	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2778
# text = We compared the effects of the deactivating cytokine interleukin 10 (IL-10) on human peripheral blood mononuclear cell (PBMC) responses to lipopolysaccharide (LPS), Cryptococcus neoformans, and Candida albicans.
1	We	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
2	compared	compare	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
3	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
4	effects	effect	NOUN	NNS	Number=Plur	_	_	_	_
5	of	of	ADP	IN	_	_	_	_	_
6	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
7	deactivating	deactivat	VERB	VBG	VerbForm=Ger	_	_	_	_
8	cytokine	cytokine	NOUN	NN	Number=Sing	_	_	_	_
9	interleukin	interleukin	NOUN	NN	Number=Sing	_	_	_	_
10	10	10	NUM	CD	NumType=Card	_	_	_	_
11	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
12	IL	Il	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
13	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
14	10	10	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
15	)	)	PUNCT	-RRB-	_	_	_	_	_
16	on	on	ADP	IN	_	_	_	_	_
17	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
18	peripheral	peripheral	ADJ	JJ	Degree=Pos	_	_	_	_
19	blood	blood	NOUN	NN	Number=Sing	_	_	_	_
20	mononuclear	mononuclear	NOUN	NN	Number=Sing	_	_	_	_
21	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
22	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
23	PBMC	Pbmc	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
24	)	)	PUNCT	-RRB-	_	_	_	_	_
25	responses	response	NOUN	NNS	Number=Plur	_	_	_	_
26	to	to	ADP	IN	_	_	_	_	_
27	lipopolysaccharide	lipopolysaccharide	NOUN	NN	Number=Sing	_	_	_	_
28	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
29	LPS	Lp	INTJ	UH	_	_	_	_	SpaceAfter=No
30	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
31	,	,	PUNCT	,	_	_	_	_	_
32	Cryptococcus	Cryptococcus	PROPN	NNP	Number=Sing	_	_	_	_
33	neoformans	neoforman	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
34	,	,	PUNCT	,	_	_	_	_	_
35	and	and	CCONJ	CC	_	_	_	_	_
36	Candida	Candida	PROPN	NNP	Number=Sing	_	_	_	_
37	albicans	albicans	PROPN	NNPS	Number=Plur	_	_	_	SpaceAfter=No
38	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2779
# text = IL-10 effected dose-dependent inhibition of tumor necrosis factor alpha (TNF-alpha) release in PBMC stimulated by LPS and C. neoformans, with significant inhibition seen with 0.1
1	IL	Il	INTJ	UH	_	_	_	_	SpaceAfter=No
2	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
3	10	10	NUM	CD	NumType=Card	_	_	_	_
4	effected	effect	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
5	dose	dose	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
6	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
7	dependent	dependent	ADJ	JJ	Degree=Pos	_	_	_	_
8	inhibition	inhibition	NOUN	NN	Number=Sing	_	_	_	_
9	of	of	ADP	IN	_	_	_	_	_
10	tumor	tumor	NOUN	NN	Number=Sing	_	_	_	_
11	necrosis	necrosis	NOUN	NN	Number=Sing	_	_	_	_
12	factor	factor	NOUN	NN	Number=Sing	_	_	_	_
13	alpha	alpha	NOUN	NN	Number=Sing	_	_	_	_
14	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
15	TNF	Tnf	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
16	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
17	alpha	alpha	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
18	)	)	PUNCT	-RRB-	_	_	_	_	_
19	release	release	NOUN	NN	Number=Sing	_	_	_	_
20	in	in	ADP	IN	_	_	_	_	_
21	PBMC	PBMC	PROPN	NNP	Number=Sing	_	_	_	_
22	stimulated	stimulate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
23	by	by	ADP	IN	_	_	_	_	_
24	LPS	LPS	PROPN	NNP	Number=Sing	_	_	_	_
25	and	and	CCONJ	CC	_	_	_	_	_
26	C.	c.	PROPN	NNP	Number=Sing	_	_	_	_
27	neoformans	neoforman	PROPN	NNPS	Number=Plur	_	_	_	SpaceAfter=No
28	,	,	PUNCT	,	_	_	_	_	_
29	with	with	ADP	IN	_	_	_	_	_
30	significant	significant	ADJ	JJ	Degree=Pos	_	_	_	_
31	inhibition	inhibition	NOUN	NN	Number=Sing	_	_	_	_
32	seen	see	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
33	with	with	ADP	IN	_	_	_	_	_
34	0.1	0.1	NUM	CD	NumType=Card	_	_	_	_

# sent_id = 2780
# text = U/ml and greater than 90% inhibition noted with 10 U/ml.
1	U/	U/	SYM	NFP	_	_	_	_	SpaceAfter=No
2	ml	ml	NOUN	NN	Number=Sing	_	_	_	_
3	and	and	CCONJ	CC	_	_	_	_	_
4	greater	greater	ADJ	JJR	Degree=Cmp	_	_	_	_
5	than	than	ADP	IN	_	_	_	_	_
6	90	90	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
7	%	%	SYM	NN	Number=Sing	_	_	_	_
8	inhibition	inhibition	NOUN	NN	Number=Sing	_	_	_	_
9	noted	note	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
10	with	with	ADP	IN	_	_	_	_	_
11	10	10	NUM	CD	NumType=Card	_	_	_	_
12	U/	U/	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
13	ml	ml	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
14	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2781
# text = In contrast, even at doses as high as 100 U/ml, IL-10 inhibited TNF-alpha release in response to C. albicans by only 50%.
1	In	in	ADP	IN	_	_	_	_	_
2	contrast	contrast	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
3	,	,	PUNCT	,	_	_	_	_	_
4	even	even	ADV	RB	_	_	_	_	_
5	at	at	ADP	IN	_	_	_	_	_
6	doses	dos	NOUN	NNS	Number=Plur	_	_	_	_
7	as	as	ADV	RB	_	_	_	_	_
8	high	high	ADJ	JJ	Degree=Pos	_	_	_	_
9	as	as	ADP	IN	_	_	_	_	_
10	100	100	NUM	CD	NumType=Card	_	_	_	_
11	U/	U/	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
12	ml	ml	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
13	,	,	PUNCT	,	_	_	_	_	_
14	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
15	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
16	10	10	NUM	CD	NumType=Card	_	_	_	_
17	inhibited	inhibit	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
18	TNF	Tnf	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
19	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
20	alpha	alpha	NOUN	NN	Number=Sing	_	_	_	_
21	release	release	NOUN	NN	Number=Sing	_	_	_	_
22	in	in	ADP	IN	_	_	_	_	_
23	response	response	NOUN	NN	Number=Sing	_	_	_	_
24	to	to	ADP	IN	_	_	_	_	_
25	C.	c.	PROPN	NNP	Number=Sing	_	_	_	_
26	albicans	albicans	PROPN	NNPS	Number=Plur	_	_	_	_
27	by	by	ADP	IN	_	_	_	_	_
28	only	only	ADV	RB	_	_	_	_	_
29	50%	50%	SYM	NN	Number=Sing	_	_	_	SpaceAfter=No
30	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2782
# text = IL-10 profoundly inhibited release of IL-1beta from PBMC stimulated by all three stimuli.
1	IL	Il	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
2	-	-	SYM	SYM	_	_	_	_	SpaceAfter=No
3	10	10	NUM	CD	NumType=Card	_	_	_	_
4	profoundly	profoundly	ADV	RB	_	_	_	_	_
5	inhibited	inhibit	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
6	release	release	NOUN	NN	Number=Sing	_	_	_	_
7	of	of	ADP	IN	_	_	_	_	_
8	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
9	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
10	1	1	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
11	beta	beta	NOUN	NN	Number=Sing	_	_	_	_
12	from	from	ADP	IN	_	_	_	_	_
13	PBMC	PBMC	PROPN	NNP	Number=Sing	_	_	_	_
14	stimulated	stimulate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
15	by	by	ADP	IN	_	_	_	_	_
16	all	all	DET	DT	_	_	_	_	_
17	three	three	NUM	CD	NumType=Card	_	_	_	_
18	stimuli	stimuli	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
19	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2783
# text = TNF-alpha mRNA and release was inhibited even if IL-10 was added up to 8 h after cryptococcal stimulation.
1	TNF	Tnf	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
2	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
3	alpha	alpha	NOUN	NN	Number=Sing	_	_	_	_
4	mRNA	mRNa	NOUN	NN	Number=Sing	_	_	_	_
5	and	and	CCONJ	CC	_	_	_	_	_
6	release	release	NOUN	NN	Number=Sing	_	_	_	_
7	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
8	inhibited	inhibit	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
9	even	even	ADV	RB	_	_	_	_	_
10	if	if	SCONJ	IN	_	_	_	_	_
11	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
12	-	-	SYM	SYM	_	_	_	_	SpaceAfter=No
13	10	10	NUM	CD	NumType=Card	_	_	_	_
14	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
15	added	add	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
16	up	up	ADP	RP	_	_	_	_	_
17	to	to	ADP	IN	_	_	_	_	_
18	8	8	NUM	CD	NumType=Card	_	_	_	_
19	h	h	NOUN	NN	Number=Sing	_	_	_	_
20	after	after	ADP	IN	_	_	_	_	_
21	cryptococcal	cryptococcal	ADJ	JJ	Degree=Pos	_	_	_	_
22	stimulation	stimulation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
23	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2784
# text = In contrast, inhibition of IL-1 beta mRNA was of lesser magnitude and occurred only when IL-10 was added within 2 h of cryptococcal stimulation.
1	In	in	ADP	IN	_	_	_	_	_
2	contrast	contrast	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
3	,	,	PUNCT	,	_	_	_	_	_
4	inhibition	inhibition	NOUN	NN	Number=Sing	_	_	_	_
5	of	of	ADP	IN	_	_	_	_	_
6	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
7	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
8	1	1	NUM	CD	NumType=Card	_	_	_	_
9	beta	beta	NOUN	NN	Number=Sing	_	_	_	_
10	mRNA	mRNA	PROPN	NNP	Number=Sing	_	_	_	_
11	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
12	of	of	ADP	IN	_	_	_	_	_
13	lesser	lesser	ADJ	JJR	Degree=Cmp	_	_	_	_
14	magnitude	magnitude	NOUN	NN	Number=Sing	_	_	_	_
15	and	and	CCONJ	CC	_	_	_	_	_
16	occurred	occur	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
17	only	only	ADV	RB	_	_	_	_	_
18	when	when	ADV	WRB	PronType=Int	_	_	_	_
19	IL	IL	SYM	$	_	_	_	_	SpaceAfter=No
20	-	-	SYM	SYM	_	_	_	_	SpaceAfter=No
21	10	10	NUM	CD	NumType=Card	_	_	_	_
22	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
23	added	add	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
24	within	within	ADP	IN	_	_	_	_	_
25	2	2	NUM	CD	NumType=Card	_	_	_	_
26	h	h	NOUN	NN	Number=Sing	_	_	_	_
27	of	of	ADP	IN	_	_	_	_	_
28	cryptococcal	cryptococcal	ADJ	JJ	Degree=Pos	_	_	_	_
29	stimulation	stimulation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
30	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2785
# text = IL-10 inhibited translocation of NF-kappaB in response to LPS but not the fungal stimuli.
1	IL	Il	INTJ	UH	_	_	_	_	SpaceAfter=No
2	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
3	10	10	NUM	CD	NumType=Card	_	_	_	_
4	inhibited	inhibit	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
5	translocation	translocation	NOUN	NN	Number=Sing	_	_	_	_
6	of	of	ADP	IN	_	_	_	_	_
7	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
8	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
9	kappaB	kappaB	PROPN	NNP	Number=Sing	_	_	_	_
10	in	in	ADP	IN	_	_	_	_	_
11	response	response	NOUN	NN	Number=Sing	_	_	_	_
12	to	to	ADP	IN	_	_	_	_	_
13	LPS	LPS	PROPN	NNP	Number=Sing	_	_	_	_
14	but	but	CCONJ	CC	_	_	_	_	_
15	not	not	PART	RB	_	_	_	_	_
16	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
17	fungal	fungal	ADJ	JJ	Degree=Pos	_	_	_	_
18	stimuli	stimuli	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
19	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2786
# text = All three stimuli induced IL-10 production in PBMC, although over 10-fold less IL-10 was released in response to C. neoformans compared with LPS and C.
1	All	all	DET	DT	_	_	_	_	_
2	three	three	NUM	CD	NumType=Card	_	_	_	_
3	stimuli	stimuli	NOUN	NN	Number=Sing	_	_	_	_
4	induced	induce	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
5	IL	Il	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
6	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
7	10	10	NUM	CD	NumType=Card	_	_	_	_
8	production	production	NOUN	NN	Number=Sing	_	_	_	_
9	in	in	ADP	IN	_	_	_	_	_
10	PBMC	PBMC	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
11	,	,	PUNCT	,	_	_	_	_	_
12	although	although	SCONJ	IN	_	_	_	_	_
13	over	over	ADP	IN	_	_	_	_	_
14	10	10	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
15	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
16	fold	fold	NOUN	NN	Number=Sing	_	_	_	_
17	less	less	ADV	RBR	Degree=Cmp	_	_	_	_
18	IL	Il	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
19	-	-	SYM	SYM	_	_	_	_	SpaceAfter=No
20	10	10	NUM	CD	NumType=Card	_	_	_	_
21	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
22	released	release	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
23	in	in	ADP	IN	_	_	_	_	_
24	response	response	NOUN	NN	Number=Sing	_	_	_	_
25	to	to	ADP	IN	_	_	_	_	_
26	C.	c.	PROPN	NNP	Number=Sing	_	_	_	_
27	neoformans	neoforman	NOUN	NNS	Number=Plur	_	_	_	_
28	compared	compare	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
29	with	with	ADP	IN	_	_	_	_	_
30	LPS	LPS	PROPN	NNP	Number=Sing	_	_	_	_
31	and	and	CCONJ	CC	_	_	_	_	_
32	C.	c.	PROPN	NNP	Number=Sing	_	_	_	_

# sent_id = 2787
# text = albicans.
1	albicans	albican	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
2	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2788
# text = Thus, while IL-10 has deactivating effects on PBMC responses to all three stimuli, disparate stimulus- and response-specific patterns of deactivation are seen.
1	Thus	thus	ADV	RB	_	_	_	_	SpaceAfter=No
2	,	,	PUNCT	,	_	_	_	_	_
3	while	while	SCONJ	IN	_	_	_	_	_
4	IL	Il	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
5	-	-	SYM	SYM	_	_	_	_	SpaceAfter=No
6	10	10	NUM	CD	NumType=Card	_	_	_	_
7	has	have	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
8	deactivating	deactivat	VERB	VBG	VerbForm=Ger	_	_	_	_
9	effects	effect	NOUN	NNS	Number=Plur	_	_	_	_
10	on	on	ADP	IN	_	_	_	_	_
11	PBMC	Pbmc	NOUN	NN	Number=Sing	_	_	_	_
12	responses	response	NOUN	NNS	Number=Plur	_	_	_	_
13	to	to	ADP	IN	_	_	_	_	_
14	all	all	DET	DT	_	_	_	_	_
15	three	three	NUM	CD	NumType=Card	_	_	_	_
16	stimuli	stimuli	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
17	,	,	PUNCT	,	_	_	_	_	_
18	disparate	disparate	ADJ	JJ	Degree=Pos	_	_	_	_
19	stimulus	stimulus	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
20	-	-	PUNCT	,	_	_	_	_	_
21	and	and	CCONJ	CC	_	_	_	_	_
22	response	response	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
23	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
24	specific	specific	ADJ	JJ	Degree=Pos	_	_	_	_
25	patterns	pattern	NOUN	NNS	Number=Plur	_	_	_	_
26	of	of	ADP	IN	_	_	_	_	_
27	deactivation	deactivation	NOUN	NN	Number=Sing	_	_	_	_
28	are	be	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
29	seen	see	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	SpaceAfter=No
30	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2789
# text = Inhibition by IL-10 of proinflammatory cytokine release appears to occur at the level of gene transcription for TNF-alpha and both transcriptionally and posttranscriptionally for IL-1beta.
1	Inhibition	Inhibition	NOUN	NN	Number=Sing	_	_	_	_
2	by	by	ADP	IN	_	_	_	_	_
3	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
4	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
5	10	10	NUM	CD	NumType=Card	_	_	_	_
6	of	of	ADP	IN	_	_	_	_	_
7	proinflammatory	proinflammatory	ADJ	JJ	Degree=Pos	_	_	_	_
8	cytokine	cytokine	NOUN	NN	Number=Sing	_	_	_	_
9	release	release	NOUN	NN	Number=Sing	_	_	_	_
10	appears	appear	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
11	to	to	PART	TO	_	_	_	_	_
12	occur	occur	VERB	VB	VerbForm=Inf	_	_	_	_
13	at	at	ADP	IN	_	_	_	_	_
14	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
15	level	level	NOUN	NN	Number=Sing	_	_	_	_
16	of	of	ADP	IN	_	_	_	_	_
17	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
18	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
19	for	for	ADP	IN	_	_	_	_	_
20	TNF	TNF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
21	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
22	alpha	alpha	NOUN	NN	Number=Sing	_	_	_	_
23	and	and	CCONJ	CC	_	_	_	_	_
24	both	both	CCONJ	CC	_	_	_	_	_
25	transcriptionally	transcriptionally	ADV	RB	_	_	_	_	_
26	and	and	CCONJ	CC	_	_	_	_	_
27	posttranscriptionally	posttranscriptionally	ADV	RB	_	_	_	_	_
28	for	for	ADP	IN	_	_	_	_	_
29	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
30	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
31	1	1	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
32	beta	beta	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
33	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 2790
# text = Document 003003316 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	003003316	003003316	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 2791
# text = The zinc finger transcription factor Egr-1 is essential for and restricts differentiation along the macrophage lineage.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	zinc	zinc	NOUN	NN	Number=Sing	_	_	_	_
3	finger	finger	NOUN	NN	Number=Sing	_	_	_	_
4	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
5	factor	factor	NOUN	NN	Number=Sing	_	_	_	_
6	Egr	Egr	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
7	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
8	1	1	NUM	CD	NumType=Card	_	_	_	_
9	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
10	essential	essential	ADJ	JJ	Degree=Pos	_	_	_	_
11	for	for	ADP	IN	_	_	_	_	_
12	and	and	CCONJ	CC	_	_	_	_	_
13	restricts	restrict	NOUN	NNS	Number=Plur	_	_	_	_
14	differentiation	differentiation	NOUN	NN	Number=Sing	_	_	_	_
15	along	along	ADP	IN	_	_	_	_	_
16	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
17	macrophage	macrophage	NOUN	NN	Number=Sing	_	_	_	_
18	lineage	lineage	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
19	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 2792
# text = We have isolated cDNA clones of myeloid differentiation primary response (MyD) genes, activated in the absence of de novo protein synthesis following induction for differentiation along either the macrophage or granulocyte lineage in human myeloblastic leukemia HL-60 cells.
1	We	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
2	have	have	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
3	isolated	isolate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
4	cDNA	cDNa	NOUN	NN	Number=Sing	_	_	_	_
5	clones	clone	NOUN	NNS	Number=Plur	_	_	_	_
6	of	of	ADP	IN	_	_	_	_	_
7	myeloid	myeloid	ADJ	JJ	Degree=Pos	_	_	_	_
8	differentiation	differentiation	NOUN	NN	Number=Sing	_	_	_	_
9	primary	primary	ADJ	JJ	Degree=Pos	_	_	_	_
10	response	response	NOUN	NN	Number=Sing	_	_	_	_
11	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
12	MyD	myd	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
13	)	)	PUNCT	-RRB-	_	_	_	_	_
14	genes	gene	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
15	,	,	PUNCT	,	_	_	_	_	_
16	activated	activate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
17	in	in	ADP	IN	_	_	_	_	_
18	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
19	absence	absence	NOUN	NN	Number=Sing	_	_	_	_
20	of	of	ADP	IN	_	_	_	_	_
21	de	de	PROPN	NNP	Number=Sing	_	_	_	_
22	novo	novo	PROPN	NNP	Number=Sing	_	_	_	_
23	protein	protein	NOUN	NN	Number=Sing	_	_	_	_
24	synthesis	synthesis	NOUN	NN	Number=Sing	_	_	_	_
25	following	follow	VERB	VBG	VerbForm=Ger	_	_	_	_
26	induction	induction	NOUN	NN	Number=Sing	_	_	_	_
27	for	for	ADP	IN	_	_	_	_	_
28	differentiation	differentiation	NOUN	NN	Number=Sing	_	_	_	_
29	along	along	ADP	IN	_	_	_	_	_
30	either	either	CCONJ	CC	_	_	_	_	_
31	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
32	macrophage	macrophage	NOUN	NN	Number=Sing	_	_	_	_
33	or	or	CCONJ	CC	_	_	_	_	_
34	granulocyte	granulocyte	NOUN	NN	Number=Sing	_	_	_	_
35	lineage	lineage	NOUN	NN	Number=Sing	_	_	_	_
36	in	in	ADP	IN	_	_	_	_	_
37	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
38	myeloblastic	myeloblastic	ADJ	JJ	Degree=Pos	_	_	_	_
39	leukemia	leukemia	NOUN	NN	Number=Sing	_	_	_	_
40	HL	Hl	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
41	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
42	60	60	NUM	CD	NumType=Card	_	_	_	_
43	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
44	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2793
# text = One cDNA clone of a primary response gene, expressed upon macrophage differentiation, encoded for Egr-1, a zinc finger transcription factor.
1	One	one	NUM	CD	NumType=Card	_	_	_	_
2	cDNA	cDNa	NOUN	NN	Number=Sing	_	_	_	_
3	clone	clone	NOUN	NN	Number=Sing	_	_	_	_
4	of	of	ADP	IN	_	_	_	_	_
5	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
6	primary	primary	ADJ	JJ	Degree=Pos	_	_	_	_
7	response	response	NOUN	NN	Number=Sing	_	_	_	_
8	gene	gene	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	SpaceAfter=No
9	,	,	PUNCT	,	_	_	_	_	_
10	expressed	express	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
11	upon	upon	ADP	IN	_	_	_	_	_
12	macrophage	macrophage	NOUN	NN	Number=Sing	_	_	_	_
13	differentiation	differentiation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
14	,	,	PUNCT	,	_	_	_	_	_
15	encoded	encode	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
16	for	for	ADP	IN	_	_	_	_	_
17	Egr	Egr	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
18	-1	-1	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
19	,	,	PUNCT	,	_	_	_	_	_
20	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
21	zinc	zinc	NOUN	NN	Number=Sing	_	_	_	_
22	finger	finger	NOUN	NN	Number=Sing	_	_	_	_
23	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
24	factor	factor	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
25	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2794
# text = The Egr-1 gene was observed to be transcriptionally silent in HL-60 cells, but active in U-937 and M1 cells, the latter two being predetermined for macrophage differentiation.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	Egr	Egr	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
3	-1	-1	NUM	CD	NumType=Card	_	_	_	_
4	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
5	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
6	observed	observe	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
7	to	to	PART	TO	_	_	_	_	_
8	be	be	AUX	VB	VerbForm=Inf	_	_	_	_
9	transcriptionally	transcriptionally	ADV	RB	_	_	_	_	_
10	silent	silent	ADJ	JJ	Degree=Pos	_	_	_	_
11	in	in	ADP	IN	_	_	_	_	_
12	HL	HL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
13	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
14	60	60	NUM	CD	NumType=Card	_	_	_	_
15	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
16	,	,	PUNCT	,	_	_	_	_	_
17	but	but	CCONJ	CC	_	_	_	_	_
18	active	active	ADJ	JJ	Degree=Pos	_	_	_	_
19	in	in	ADP	IN	_	_	_	_	_
20	U	U	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
21	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
22	937	937	NUM	CD	NumType=Card	_	_	_	_
23	and	and	CCONJ	CC	_	_	_	_	_
24	M1	M1	NUM	CD	NumType=Card	_	_	_	_
25	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
26	,	,	PUNCT	,	_	_	_	_	_
27	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
28	latter	latter	ADJ	JJ	Degree=Pos	_	_	_	_
29	two	two	NUM	CD	NumType=Card	_	_	_	_
30	being	be	AUX	VBG	VerbForm=Ger	_	_	_	_
31	predetermined	predetermine	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
32	for	for	ADP	IN	_	_	_	_	_
33	macrophage	macrophage	NOUN	NN	Number=Sing	_	_	_	_
34	differentiation	differentiation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
35	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2795
# text = Egr-1 antisense oligomers in the culture media blocked macrophage differentiation in both myeloid leukemia cell lines and normal myeloblasts.
1	Egr	Egr	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
2	-1	-1	NUM	CD	NumType=Card	_	_	_	_
3	antisense	antisense	ADJ	JJ	Degree=Pos	_	_	_	_
4	oligomers	oligomer	NOUN	NNS	Number=Plur	_	_	_	_
5	in	in	ADP	IN	_	_	_	_	_
6	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
7	culture	culture	NOUN	NN	Number=Sing	_	_	_	_
8	media	media	NOUN	NN	Number=Sing	_	_	_	_
9	blocked	block	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
10	macrophage	macrophage	NOUN	NN	Number=Sing	_	_	_	_
11	differentiation	differentiation	NOUN	NN	Number=Sing	_	_	_	_
12	in	in	ADP	IN	_	_	_	_	_
13	both	both	DET	DT	_	_	_	_	_
14	myeloid	myeloid	ADJ	JJ	Degree=Pos	_	_	_	_
15	leukemia	leukemia	NOUN	NN	Number=Sing	_	_	_	_
16	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
17	lines	line	NOUN	NNS	Number=Plur	_	_	_	_
18	and	and	CCONJ	CC	_	_	_	_	_
19	normal	normal	ADJ	JJ	Degree=Pos	_	_	_	_
20	myeloblasts	myeloblast	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
21	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2796
# text = HL-60 cells constitutively expressing an Egr-1 transgene (HL-60Egr-1) could be induced for macrophage, but not granulocyte, differentiation.
1	HL	Hl	INTJ	UH	_	_	_	_	SpaceAfter=No
2	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
3	60	60	NUM	CD	NumType=Card	_	_	_	_
4	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
5	constitutively	constitutively	ADV	RB	_	_	_	_	_
6	expressing	express	VERB	VBG	VerbForm=Ger	_	_	_	_
7	an	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
8	Egr	Egr	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
9	-1	-1	NUM	CD	NumType=Card	_	_	_	_
10	transgene	transgene	NOUN	NN	Number=Sing	_	_	_	_
11	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
12	HL-	HL-	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
13	60Egr	60Egr	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
14	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
15	1	1	X	LS	_	_	_	_	SpaceAfter=No
16	)	)	PUNCT	-RRB-	_	_	_	_	_
17	could	could	AUX	MD	VerbForm=Fin	_	_	_	_
18	be	be	AUX	VB	VerbForm=Inf	_	_	_	_
19	induced	induce	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
20	for	for	ADP	IN	_	_	_	_	_
21	macrophage	macrophage	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
22	,	,	PUNCT	,	_	_	_	_	_
23	but	but	CCONJ	CC	_	_	_	_	_
24	not	not	ADV	RB	_	_	_	_	_
25	granulocyte	granulocyte	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
26	,	,	PUNCT	,	_	_	_	_	_
27	differentiation	differentiation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
28	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2797
# text = These observations indicate that expression of Egr-1 is essential for and restricts differentiation of myeloblasts along the macrophage lineage.
1	These	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
2	observations	observation	NOUN	NNS	Number=Plur	_	_	_	_
3	indicate	indicate	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
4	that	that	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
5	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
6	of	of	ADP	IN	_	_	_	_	_
7	Egr	Egr	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
8	-1	-1	NUM	CD	NumType=Card	_	_	_	_
9	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
10	essential	essential	ADJ	JJ	Degree=Pos	_	_	_	_
11	for	for	ADP	IN	_	_	_	_	_
12	and	and	CCONJ	CC	_	_	_	_	_
13	restricts	restrict	NOUN	NNS	Number=Plur	_	_	_	_
14	differentiation	differentiation	NOUN	NN	Number=Sing	_	_	_	_
15	of	of	ADP	IN	_	_	_	_	_
16	myeloblasts	myeloblast	NOUN	NNS	Number=Plur	_	_	_	_
17	along	along	ADP	IN	_	_	_	_	_
18	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
19	macrophage	macrophage	NOUN	NN	Number=Sing	_	_	_	_
20	lineage	lineage	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
21	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 2798
# text = Document 003003321 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	003003321	003003321	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 2799
# text = [Glucocorticoid receptors on human peripheral mononuclear and polymorphonuclear leucocytes: changes in patients with yang-deficiency]
1	[	[	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
2	Glucocorticoid	Glucocorticoid	VERB	VB	Mood=Imp|VerbForm=Fin	_	_	_	_
3	receptors	receptor	NOUN	NNS	Number=Plur	_	_	_	_
4	on	on	ADP	IN	_	_	_	_	_
5	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
6	peripheral	peripheral	ADJ	JJ	Degree=Pos	_	_	_	_
7	mononuclear	mononuclear	NOUN	NN	Number=Sing	_	_	_	_
8	and	and	CCONJ	CC	_	_	_	_	_
9	polymorphonuclear	polymorphonuclear	ADJ	JJ	Degree=Pos	_	_	_	_
10	leucocytes	leucocyte	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
11	:	:	PUNCT	:	_	_	_	_	_
12	changes	change	NOUN	NNS	Number=Plur	_	_	_	_
13	in	in	ADP	IN	_	_	_	_	_
14	patients	patient	NOUN	NNS	Number=Plur	_	_	_	_
15	with	with	ADP	IN	_	_	_	_	_
16	yang	yang	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
17	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
18	deficiency	deficiency	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
19	]	]	PUNCT	-RRB-	_	_	_	_	SpacesAfter=\s\n

# sent_id = 2800
# text = It was found that, in former works, the glucocorticoid receptors (GCR) on peripheral mixed leucocytes in patients with Yang-deficiency were decreased.
1	It	it	PRON	PRP	Case=Nom|Gender=Neut|Number=Sing|Person=3|PronType=Prs	_	_	_	_
2	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
3	found	find	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
4	that	that	SCONJ	IN	_	_	_	_	SpaceAfter=No
5	,	,	PUNCT	,	_	_	_	_	_
6	in	in	ADP	IN	_	_	_	_	_
7	former	former	ADJ	JJ	Degree=Pos	_	_	_	_
8	works	work	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
9	,	,	PUNCT	,	_	_	_	_	_
10	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
11	glucocorticoid	glucocorticoid	ADJ	JJ	Degree=Pos	_	_	_	_
12	receptors	receptor	NOUN	NNS	Number=Plur	_	_	_	_
13	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
14	GCR	GCR	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
15	)	)	PUNCT	-RRB-	_	_	_	_	_
16	on	on	ADP	IN	_	_	_	_	_
17	peripheral	peripheral	ADJ	JJ	Degree=Pos	_	_	_	_
18	mixed	mix	ADJ	JJ	Degree=Pos	_	_	_	_
19	leucocytes	leucocyte	NOUN	NNS	Number=Plur	_	_	_	_
20	in	in	ADP	IN	_	_	_	_	_
21	patients	patient	NOUN	NNS	Number=Plur	_	_	_	_
22	with	with	ADP	IN	_	_	_	_	_
23	Yang	Yang	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
24	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
25	deficiency	deficiency	NOUN	NN	Number=Sing	_	_	_	_
26	were	be	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
27	decreased	decrease	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	SpaceAfter=No
28	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2801
# text = In this work, the mixed leucocytes were further separated into mononuclear (MNL) and polymorphonuclear (PML) leucocytes, and GCR were determined in each part of leucocytes.
1	In	in	ADP	IN	_	_	_	_	_
2	this	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
3	work	work	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
4	,	,	PUNCT	,	_	_	_	_	_
5	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
6	mixed	mixed	ADJ	JJ	Degree=Pos	_	_	_	_
7	leucocytes	leucocyte	NOUN	NNS	Number=Plur	_	_	_	_
8	were	be	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
9	further	further	ADV	RB	_	_	_	_	_
10	separated	separate	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
11	into	into	ADP	IN	_	_	_	_	_
12	mononuclear	mononuclear	NOUN	NN	Number=Sing	_	_	_	_
13	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
14	MNL	MNL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
15	)	)	PUNCT	-RRB-	_	_	_	_	_
16	and	and	CCONJ	CC	_	_	_	_	_
17	polymorphonuclear	polymorphonuclear	NOUN	NN	Number=Sing	_	_	_	_
18	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
19	PML	pMl	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
20	)	)	PUNCT	-RRB-	_	_	_	_	_
21	leucocytes	leucocyte	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
22	,	,	PUNCT	,	_	_	_	_	_
23	and	and	CCONJ	CC	_	_	_	_	_
24	GCR	GCR	ADV	RBR	Degree=Cmp	_	_	_	_
25	were	be	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
26	determined	determine	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
27	in	in	ADP	IN	_	_	_	_	_
28	each	each	DET	DT	_	_	_	_	_
29	part	part	NOUN	NN	Number=Sing	_	_	_	_
30	of	of	ADP	IN	_	_	_	_	_
31	leucocytes	leucocyte	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
32	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2802
# text = GCR on MNL and PML in 6 Yang deficient patients were 3473 +/- 413 and 4433 +/- 651 sites/cell respectively, statistically significant from the normal control group (4462 +/- 962 and 5622 +/- 782 sites/cell respectively, P less than 0.05).
1	GCR	Gcr	VERB	VB	Mood=Imp|VerbForm=Fin	_	_	_	_
2	on	on	ADP	IN	_	_	_	_	_
3	MNL	MNL	NOUN	NN	Number=Sing	_	_	_	_
4	and	and	CCONJ	CC	_	_	_	_	_
5	PML	PML	NOUN	NN	Number=Sing	_	_	_	_
6	in	in	ADP	IN	_	_	_	_	_
7	6	6	NUM	CD	NumType=Card	_	_	_	_
8	Yang	Yang	PROPN	NNP	Number=Sing	_	_	_	_
9	deficient	deficient	ADJ	JJ	Degree=Pos	_	_	_	_
10	patients	patient	NOUN	NNS	Number=Plur	_	_	_	_
11	were	be	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
12	3473	3473	NUM	CD	NumType=Card	_	_	_	_
13	+/-	+/-	SYM	SYM	_	_	_	_	_
14	413	413	NUM	CD	NumType=Card	_	_	_	_
15	and	and	CCONJ	CC	_	_	_	_	_
16	4433	4433	NUM	CD	NumType=Card	_	_	_	_
17	+/-	+/-	SYM	SYM	_	_	_	_	_
18	651	651	NUM	CD	NumType=Card	_	_	_	_
19	sites	site	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
20	/	/	PUNCT	,	_	_	_	_	SpaceAfter=No
21	cell	cell	VERB	VB	Mood=Imp|VerbForm=Fin	_	_	_	_
22	respectively	respectively	ADV	RB	_	_	_	_	SpaceAfter=No
23	,	,	PUNCT	,	_	_	_	_	_
24	statistically	statistically	ADV	RB	_	_	_	_	_
25	significant	significant	ADJ	JJ	Degree=Pos	_	_	_	_
26	from	from	ADP	IN	_	_	_	_	_
27	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
28	normal	normal	ADJ	JJ	Degree=Pos	_	_	_	_
29	control	control	NOUN	NN	Number=Sing	_	_	_	_
30	group	group	NOUN	NN	Number=Sing	_	_	_	_
31	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
32	4462	4462	NUM	CD	NumType=Card	_	_	_	_
33	+/-	+/-	SYM	SYM	_	_	_	_	_
34	962	962	NUM	CD	NumType=Card	_	_	_	_
35	and	and	CCONJ	CC	_	_	_	_	_
36	5622	5622	NUM	CD	NumType=Card	_	_	_	_
37	+/-	+/-	SYM	SYM	_	_	_	_	_
38	782	782	NUM	CD	NumType=Card	_	_	_	_
39	sites	site	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
40	/	/	PUNCT	,	_	_	_	_	SpaceAfter=No
41	cell	cell	VERB	VB	Mood=Imp|VerbForm=Fin	_	_	_	_
42	respectively	respectively	ADV	RB	_	_	_	_	SpaceAfter=No
43	,	,	PUNCT	,	_	_	_	_	_
44	P	p	VERB	VB	Mood=Imp|VerbForm=Fin	_	_	_	_
45	less	less	ADJ	JJR	Degree=Cmp	_	_	_	_
46	than	than	ADP	IN	_	_	_	_	_
47	0.05	0.05	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
48	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
49	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2803
# text = GCR on MNL, PML and mixed leucocytes in 5 patients were determined simultaneously, and all lowered from the control group.
1	GCR	Gcr	VERB	VB	Mood=Imp|VerbForm=Fin	_	_	_	_
2	on	on	ADP	IN	_	_	_	_	_
3	MNL	MNL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
4	,	,	PUNCT	,	_	_	_	_	_
5	PML	PML	PROPN	NNP	Number=Sing	_	_	_	_
6	and	and	CCONJ	CC	_	_	_	_	_
7	mixed	mix	ADJ	JJ	Degree=Pos	_	_	_	_
8	leucocytes	leucocyte	NOUN	NNS	Number=Plur	_	_	_	_
9	in	in	ADP	IN	_	_	_	_	_
10	5	5	NUM	CD	NumType=Card	_	_	_	_
11	patients	patient	NOUN	NNS	Number=Plur	_	_	_	_
12	were	be	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
13	determined	determine	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
14	simultaneously	simultaneously	ADV	RB	_	_	_	_	SpaceAfter=No
15	,	,	PUNCT	,	_	_	_	_	_
16	and	and	CCONJ	CC	_	_	_	_	_
17	all	all	ADV	RB	_	_	_	_	_
18	lowered	lower	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
19	from	from	ADP	IN	_	_	_	_	_
20	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
21	control	control	NOUN	NN	Number=Sing	_	_	_	_
22	group	group	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
23	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2804
# text = The results were 3369 +/- 370, 4986 +/- 419 and 4524 +/- 852 sites/cell respectively, with the lowest GCR on MNL and highest on PML.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	results	result	NOUN	NNS	Number=Plur	_	_	_	_
3	were	be	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
4	3369	3369	NUM	CD	NumType=Card	_	_	_	_
5	+/-	+/-	SYM	SYM	_	_	_	_	_
6	370	370	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
7	,	,	PUNCT	,	_	_	_	_	_
8	4986	4986	NUM	CD	NumType=Card	_	_	_	_
9	+/-	+/-	SYM	SYM	_	_	_	_	_
10	419	419	NUM	CD	NumType=Card	_	_	_	_
11	and	and	CCONJ	CC	_	_	_	_	_
12	4524	4524	NUM	CD	NumType=Card	_	_	_	_
13	+/-	+/-	SYM	SYM	_	_	_	_	_
14	852	852	NUM	CD	NumType=Card	_	_	_	_
15	sites	site	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
16	/	/	PUNCT	,	_	_	_	_	SpaceAfter=No
17	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
18	respectively	respectively	ADV	RB	_	_	_	_	SpaceAfter=No
19	,	,	PUNCT	,	_	_	_	_	_
20	with	with	ADP	IN	_	_	_	_	_
21	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
22	lowest	lowest	ADJ	JJS	Degree=Sup	_	_	_	_
23	GCR	Gcr	PROPN	NNP	Number=Sing	_	_	_	_
24	on	on	ADP	IN	_	_	_	_	_
25	MNL	MNL	PROPN	NNP	Number=Sing	_	_	_	_
26	and	and	CCONJ	CC	_	_	_	_	_
27	highest	highest	ADJ	JJS	Degree=Sup	_	_	_	_
28	on	on	ADP	IN	_	_	_	_	_
29	PML	PML	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
30	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 2805
# text = Document 003003324 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	003003324	003003324	NUM	CD	NumType=Card	_	_	_	_
3	ends.	ends.	NOUN	NN	Number=Sing	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 2806
# text = p70(s6k) integrates phosphatidylinositol 3-kinase and rapamycin-regulated signals for E2F regulation in T lymphocytes.
1	p70	p70	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
2	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
3	s6	s6	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
4	k	k	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
5	)	)	PUNCT	-RRB-	_	_	_	_	_
6	integrates	integrate	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
7	phosphatidylinositol	phosphatidylinositol	INTJ	UH	_	_	_	_	_
8	3	3	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
9	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
10	kinase	kinase	NOUN	NN	Number=Sing	_	_	_	_
11	and	and	CCONJ	CC	_	_	_	_	_
12	rapamycin-	rapamycin-	PUNCT	,	_	_	_	_	SpaceAfter=No
13	regulated	regulate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
14	signals	signal	NOUN	NNS	Number=Plur	_	_	_	_
15	for	for	ADP	IN	_	_	_	_	_
16	E2	E2	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
17	F	F	PROPN	NNP	Number=Sing	_	_	_	_
18	regulation	regulation	NOUN	NN	Number=Sing	_	_	_	_
19	in	in	ADP	IN	_	_	_	_	_
20	T	t	PROPN	NNP	Number=Sing	_	_	_	_
21	lymphocytes	lymphocyte	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
22	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 2807
# text = In T lymphocytes, the hematopoietic cytokine interleukin-2 (IL-2) uses phosphatidylinositol 3-kinase (PI 3-kinase)-induced signaling pathways to regulate E2F transcriptional activity, a critical cell cycle checkpoint.
1	In	in	ADP	IN	_	_	_	_	_
2	T	t	PROPN	NNP	Number=Sing	_	_	_	_
3	lymphocytes	lymphocyte	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	,	,	PUNCT	,	_	_	_	_	_
5	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
6	hematopoietic	hematopoietic	ADJ	JJ	Degree=Pos	_	_	_	_
7	cytokine	cytokine	NOUN	NN	Number=Sing	_	_	_	_
8	interleukin	interleukin	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
9	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
10	2	2	NUM	CD	NumType=Card	_	_	_	_
11	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
12	IL	Il	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
13	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
14	2	2	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
15	)	)	PUNCT	-RRB-	_	_	_	_	_
16	uses	use	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
17	phosphatidylinositol	phosphatidylinositol	INTJ	UH	_	_	_	_	_
18	3	3	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
19	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
20	kinase	kinase	NOUN	NN	Number=Sing	_	_	_	_
21	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
22	PI	Pi	NUM	CD	NumType=Card	_	_	_	_
23	3	3	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
24	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
25	kinase	kinase	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
26	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
27	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
28	induced	induce	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
29	signaling	signaling	NOUN	NN	Number=Sing	_	_	_	_
30	pathways	pathway	NOUN	NNS	Number=Plur	_	_	_	_
31	to	to	PART	TO	_	_	_	_	_
32	regulate	regulate	VERB	VB	VerbForm=Inf	_	_	_	_
33	E2F	E2F	ADP	RP	_	_	_	_	_
34	transcriptional	transcriptional	ADJ	JJ	Degree=Pos	_	_	_	_
35	activity	activity	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
36	,	,	PUNCT	,	_	_	_	_	_
37	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
38	critical	critical	ADJ	JJ	Degree=Pos	_	_	_	_
39	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
40	cycle	cycle	NOUN	NN	Number=Sing	_	_	_	_
41	checkpoint	checkpoint	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
42	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2808
# text = PI 3-kinase also regulates the activity of p70(s6k), the 40S ribosomal protein S6 kinase, a response that is abrogated by the macrolide rapamycin.
1	PI	PI	NOUN	NN	Number=Sing	_	_	_	_
2	3	3	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
3	-	-	PUNCT	:	_	_	_	_	SpaceAfter=No
4	kinase	kinase	NOUN	NN	Number=Sing	_	_	_	_
5	also	also	ADV	RB	_	_	_	_	_
6	regulates	regulate	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
7	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
8	activity	activity	NOUN	NN	Number=Sing	_	_	_	_
9	of	of	ADP	IN	_	_	_	_	_
10	p70	p70	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
11	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
12	s6	s6	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
13	k	k	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
14	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
15	,	,	PUNCT	,	_	_	_	_	_
16	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
17	40	40	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
18	S	's	NOUN	NN	Number=Sing	_	_	_	_
19	ribosomal	ribosomal	ADJ	JJ	Degree=Pos	_	_	_	_
20	protein	protein	NOUN	NN	Number=Sing	_	_	_	_
21	S6	S6	NUM	CD	NumType=Card	_	_	_	_
22	kinase	kinase	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
23	,	,	PUNCT	,	_	_	_	_	_
24	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
25	response	response	NOUN	NN	Number=Sing	_	_	_	_
26	that	that	PRON	WDT	PronType=Rel	_	_	_	_
27	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
28	abrogated	abrogate	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
29	by	by	ADP	IN	_	_	_	_	_
30	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
31	macrolide	macrolide	ADJ	JJ	Degree=Pos	_	_	_	_
32	rapamycin	rapamycin	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
33	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2809
# text = This immunosuppressive drug is known to prevent T-cell proliferation, but the precise point at which rapamycin regulates T-cell cycle progression has yet to be elucidated.
1	This	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
2	immunosuppressive	immunosuppressive	ADJ	JJ	Degree=Pos	_	_	_	_
3	drug	drug	NOUN	NN	Number=Sing	_	_	_	_
4	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
5	known	know	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
6	to	to	PART	TO	_	_	_	_	_
7	prevent	prevent	VERB	VB	VerbForm=Inf	_	_	_	_
8	T-	t-	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
9	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
10	proliferation	proliferation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
11	,	,	PUNCT	,	_	_	_	_	_
12	but	but	CCONJ	CC	_	_	_	_	_
13	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
14	precise	precise	ADJ	JJ	Degree=Pos	_	_	_	_
15	point	point	NOUN	NN	Number=Sing	_	_	_	_
16	at	at	ADP	IN	_	_	_	_	_
17	which	which	PRON	WDT	PronType=Rel	_	_	_	_
18	rapamycin	rapamycin	NOUN	NN	Number=Sing	_	_	_	_
19	regulates	regulate	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
20	T-	T-	PUNCT	:	_	_	_	_	SpaceAfter=No
21	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
22	cycle	cycle	NOUN	NN	Number=Sing	_	_	_	_
23	progression	progression	NOUN	NN	Number=Sing	_	_	_	_
24	has	have	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
25	yet	yet	ADV	RB	_	_	_	_	_
26	to	to	PART	TO	_	_	_	_	_
27	be	be	AUX	VB	VerbForm=Inf	_	_	_	_
28	elucidated	elucidate	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	SpaceAfter=No
29	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2810
# text = Moreover, the effects of rapamycin on, and the role of p70(s6k) in, IL-2 and PI 3-kinase activation of E2Fs have not been characterized.
1	Moreover	moreover	ADV	RB	_	_	_	_	SpaceAfter=No
2	,	,	PUNCT	,	_	_	_	_	_
3	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
4	effects	effect	NOUN	NNS	Number=Plur	_	_	_	_
5	of	of	ADP	IN	_	_	_	_	_
6	rapamycin	rapamycin	NOUN	NN	Number=Sing	_	_	_	_
7	on	on	ADV	RB	_	_	_	_	SpaceAfter=No
8	,	,	PUNCT	,	_	_	_	_	_
9	and	and	CCONJ	CC	_	_	_	_	_
10	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
11	role	role	NOUN	NN	Number=Sing	_	_	_	_
12	of	of	ADP	IN	_	_	_	_	_
13	p70	p70	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
14	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
15	s6	s6	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
16	k	k	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
17	)	)	PUNCT	-RRB-	_	_	_	_	_
18	in	in	ADP	IN	_	_	_	_	SpaceAfter=No
19	,	,	PUNCT	,	_	_	_	_	_
20	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
21	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
22	2	2	NUM	CD	NumType=Card	_	_	_	_
23	and	and	CCONJ	CC	_	_	_	_	_
24	PI	PI	NUM	CD	NumType=Card	_	_	_	_
25	3	3	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
26	-	-	PUNCT	:	_	_	_	_	SpaceAfter=No
27	kinase	kinase	NOUN	NN	Number=Sing	_	_	_	_
28	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
29	of	of	ADP	IN	_	_	_	_	_
30	E2	E2	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
31	Fs	F	NOUN	NNS	Number=Plur	_	_	_	_
32	have	have	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
33	not	not	PART	RB	_	_	_	_	_
34	been	be	AUX	VBN	Tense=Past|VerbForm=Part	_	_	_	_
35	characterized	characterize	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	SpaceAfter=No
36	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2811
# text = Our present results show that IL-2- and PI 3-kinase-induced pathways for the regulation of E2F transcriptional activity include both rapamycin-resistant and rapamycin-sensitive components.
1	Our	we	PRON	PRP$	Number=Plur|Person=1|Poss=Yes|PronType=Prs	_	_	_	_
2	present	present	ADJ	JJ	Degree=Pos	_	_	_	_
3	results	result	NOUN	NNS	Number=Plur	_	_	_	_
4	show	show	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
5	that	that	SCONJ	IN	_	_	_	_	_
6	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
7	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
8	2	2	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
9	-	-	PUNCT	HYPH	_	_	_	_	_
10	and	and	CCONJ	CC	_	_	_	_	_
11	PI	PI	PROPN	NNP	Number=Sing	_	_	_	_
12	3	3	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
13	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
14	kinase	kinase	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
15	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
16	induced	induce	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
17	pathways	pathway	NOUN	NNS	Number=Plur	_	_	_	_
18	for	for	ADP	IN	_	_	_	_	_
19	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
20	regulation	regulation	NOUN	NN	Number=Sing	_	_	_	_
21	of	of	ADP	IN	_	_	_	_	_
22	E2F	E2F	PROPN	NNP	Number=Sing	_	_	_	_
23	transcriptional	transcriptional	ADJ	JJ	Degree=Pos	_	_	_	_
24	activity	activity	NOUN	NN	Number=Sing	_	_	_	_
25	include	include	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
26	both	both	CCONJ	CC	_	_	_	_	_
27	rapamycin-	rapamycin-	SYM	NFP	_	_	_	_	SpaceAfter=No
28	resistant	resistant	NOUN	NN	Number=Sing	_	_	_	_
29	and	and	CCONJ	CC	_	_	_	_	_
30	rapamycin-	rapamycin-	SYM	NFP	_	_	_	_	SpaceAfter=No
31	sensitive	sensitive	ADJ	JJ	Degree=Pos	_	_	_	_
32	components	component	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
33	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2812
# text = Expression of a rapamycin-resistant mutant of p70(s6k) in T cells could restore rapamycin-suppressed E2F responses.
1	Expression	expression	NOUN	NN	Number=Sing	_	_	_	_
2	of	of	ADP	IN	_	_	_	_	_
3	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
4	rapamycin-	rapamycin-	SYM	SYM	_	_	_	_	SpaceAfter=No
5	resistant	resistant	ADJ	JJ	Degree=Pos	_	_	_	_
6	mutant	mutant	NOUN	NN	Number=Sing	_	_	_	_
7	of	of	ADP	IN	_	_	_	_	_
8	p70	p70	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
9	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
10	s6	s6	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
11	k	k	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
12	)	)	PUNCT	-RRB-	_	_	_	_	_
13	in	in	ADP	IN	_	_	_	_	_
14	T	t	PROPN	NNP	Number=Sing	_	_	_	_
15	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
16	could	could	AUX	MD	VerbForm=Fin	_	_	_	_
17	restore	restore	VERB	VB	VerbForm=Inf	_	_	_	_
18	rapamycin-	rapamycin-	PUNCT	:	_	_	_	_	SpaceAfter=No
19	suppressed	suppress	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
20	E2	E2	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
21	F	f	PROPN	NNP	Number=Sing	_	_	_	_
22	responses	response	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
23	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2813
# text = Thus, the rapamycin-controlled processes involved in E2F regulation appear to be mediated by p70(s6k).
1	Thus	thus	ADV	RB	_	_	_	_	SpaceAfter=No
2	,	,	PUNCT	,	_	_	_	_	_
3	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
4	rapamycin-	rapamycin-	SYM	NFP	_	_	_	_	SpaceAfter=No
5	controlled	control	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
6	processes	process	NOUN	NNS	Number=Plur	_	_	_	_
7	involved	involve	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
8	in	in	ADP	IN	_	_	_	_	_
9	E2	E2	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
10	F	F	PROPN	NNP	Number=Sing	_	_	_	_
11	regulation	regulation	NOUN	NN	Number=Sing	_	_	_	_
12	appear	appear	VERB	VB	VerbForm=Inf	_	_	_	_
13	to	to	PART	TO	_	_	_	_	_
14	be	be	AUX	VB	VerbForm=Inf	_	_	_	_
15	mediated	mediate	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
16	by	by	ADP	IN	_	_	_	_	_
17	p70	p70	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
18	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
19	s6	s6	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
20	k	k	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
21	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
22	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2814
# text = However, the rapamycin-resistant p70(s6k) could not rescue rapamycin inhibition of T-cell cycle entry, consistent with the involvement of additional, rapamycin-sensitive pathways in the control of T-cell cycle progression.
1	However	however	ADV	RB	_	_	_	_	SpaceAfter=No
2	,	,	PUNCT	,	_	_	_	_	_
3	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
4	rapamycin-	rapamycin-	SYM	NFP	_	_	_	_	SpaceAfter=No
5	resistant	resistant	ADJ	JJ	Degree=Pos	_	_	_	_
6	p70	p70	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
7	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
8	s6	s6	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
9	k	k	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
10	)	)	PUNCT	-RRB-	_	_	_	_	_
11	could	could	AUX	MD	VerbForm=Fin	_	_	_	_
12	not	not	PART	RB	_	_	_	_	_
13	rescue	rescue	VERB	VB	VerbForm=Inf	_	_	_	_
14	rapamycin	rapamycin	ADP	IN	_	_	_	_	_
15	inhibition	inhibition	NOUN	NN	Number=Sing	_	_	_	_
16	of	of	ADP	IN	_	_	_	_	_
17	T-	t-	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
18	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
19	cycle	cycle	NOUN	NN	Number=Sing	_	_	_	_
20	entry	entry	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
21	,	,	PUNCT	,	_	_	_	_	_
22	consistent	consistent	ADJ	JJ	Degree=Pos	_	_	_	_
23	with	with	ADP	IN	_	_	_	_	_
24	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
25	involvement	involvement	NOUN	NN	Number=Sing	_	_	_	_
26	of	of	ADP	IN	_	_	_	_	_
27	additional	additional	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
28	,	,	PUNCT	,	_	_	_	_	_
29	rapamycin-	rapamycin-	SYM	NFP	_	_	_	_	SpaceAfter=No
30	sensitive	sensitive	ADJ	JJ	Degree=Pos	_	_	_	_
31	pathways	pathway	NOUN	NNS	Number=Plur	_	_	_	_
32	in	in	ADP	IN	_	_	_	_	_
33	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
34	control	control	NOUN	NN	Number=Sing	_	_	_	_
35	of	of	ADP	IN	_	_	_	_	_
36	T-	t-	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
37	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
38	cycle	cycle	NOUN	NN	Number=Sing	_	_	_	_
39	progression	progression	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
40	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2815
# text = The present results thus show that p70(s6k) is able to regulate E2F transcriptional activity and provide direct evidence for the first time for a link between IL-2 receptors, PI 3-kinase, and p70(s6k) that regulates a crucial G1 checkpoint in T lymphocytes.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	present	present	ADJ	JJ	Degree=Pos	_	_	_	_
3	results	result	NOUN	NNS	Number=Plur	_	_	_	_
4	thus	thus	ADV	RB	_	_	_	_	_
5	show	show	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
6	that	that	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
7	p70	p70	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
8	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
9	s6	s6	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
10	k	k	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
11	)	)	PUNCT	-RRB-	_	_	_	_	_
12	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
13	able	able	ADJ	JJ	Degree=Pos	_	_	_	_
14	to	to	PART	TO	_	_	_	_	_
15	regulate	regulate	VERB	VB	VerbForm=Inf	_	_	_	_
16	E2F	E2F	ADP	RP	_	_	_	_	_
17	transcriptional	transcriptional	ADJ	JJ	Degree=Pos	_	_	_	_
18	activity	activity	NOUN	NN	Number=Sing	_	_	_	_
19	and	and	CCONJ	CC	_	_	_	_	_
20	provide	provide	VERB	VB	VerbForm=Inf	_	_	_	_
21	direct	direct	ADJ	JJ	Degree=Pos	_	_	_	_
22	evidence	evidence	NOUN	NN	Number=Sing	_	_	_	_
23	for	for	ADP	IN	_	_	_	_	_
24	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
25	first	first	ADJ	JJ	Degree=Pos|NumType=Ord	_	_	_	_
26	time	time	NOUN	NN	Number=Sing	_	_	_	_
27	for	for	ADP	IN	_	_	_	_	_
28	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
29	link	link	NOUN	NN	Number=Sing	_	_	_	_
30	between	between	ADP	IN	_	_	_	_	_
31	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
32	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
33	2	2	NUM	CD	NumType=Card	_	_	_	_
34	receptors	receptor	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
35	,	,	PUNCT	,	_	_	_	_	_
36	PI	pi	NOUN	NN	Number=Sing	_	_	_	_
37	3	3	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
38	-	-	PUNCT	:	_	_	_	_	SpaceAfter=No
39	kinase	kinase	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
40	,	,	PUNCT	,	_	_	_	_	_
41	and	and	CCONJ	CC	_	_	_	_	_
42	p70	p70	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
43	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
44	s6	s6	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
45	k	k	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
46	)	)	PUNCT	-RRB-	_	_	_	_	_
47	that	that	PRON	WDT	PronType=Rel	_	_	_	_
48	regulates	regulate	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
49	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
50	crucial	crucial	ADJ	JJ	Degree=Pos	_	_	_	_
51	G1	g1	NOUN	NN	Number=Sing	_	_	_	_
52	checkpoint	checkpoint	NOUN	NN	Number=Sing	_	_	_	_
53	in	in	ADP	IN	_	_	_	_	_
54	T	t	PROPN	NNP	Number=Sing	_	_	_	_
55	lymphocytes	lymphocyte	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
56	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 2816
# text = Document 003003327 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	003003327	003003327	NUM	CD	NumType=Card	_	_	_	_
3	ends.	ends.	NOUN	NN	Number=Sing	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 2817
# text = USF/c-Myc enhances, while Yin-Yang 1 suppresses, the promoter activity of CXCR4, a coreceptor for HIV-1 entry.
1	USF/	USF/	SYM	NFP	_	_	_	_	SpaceAfter=No
2	c	c	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
3	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
4	Myc	Myc	NOUN	NN	Number=Sing	_	_	_	_
5	enhances	enhance	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
6	,	,	PUNCT	,	_	_	_	_	_
7	while	while	SCONJ	IN	_	_	_	_	_
8	Yin	Yin	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
9	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
10	Yang	Yang	PROPN	NNP	Number=Sing	_	_	_	_
11	1	1	NUM	CD	NumType=Card	_	_	_	_
12	suppresses	suppress	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
13	,	,	PUNCT	,	_	_	_	_	_
14	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
15	promoter	promoter	ADJ	JJ	Degree=Pos	_	_	_	_
16	activity	activity	NOUN	NN	Number=Sing	_	_	_	_
17	of	of	ADP	IN	_	_	_	_	_
18	CXCR4	CXCR4	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
19	,	,	PUNCT	,	_	_	_	_	_
20	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
21	coreceptor	coreceptor	NOUN	NN	Number=Sing	_	_	_	_
22	for	for	ADP	IN	_	_	_	_	_
23	HIV	HIV	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
24	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
25	1	1	NUM	CD	NumType=Card	_	_	_	_
26	entry	entry	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
27	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 2818
# text = Transcription factors USF1 and USF2 up-regulate gene expression (i.e., HIV-1 long terminal repeats) via interaction with an E box on their target promoters, which is also a binding site for c-Myc.
1	Transcription	Transcription	NOUN	NN	Number=Sing	_	_	_	_
2	factors	factor	NOUN	NNS	Number=Plur	_	_	_	_
3	USF1	USF1	NUM	CD	NumType=Card	_	_	_	_
4	and	and	CCONJ	CC	_	_	_	_	_
5	USF2	USF2	NUM	CD	NumType=Card	_	_	_	_
6	up	up	ADV	RB	_	_	_	_	SpaceAfter=No
7	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
8	regulate	regulate	VERB	VB	VerbForm=Inf	_	_	_	_
9	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
10	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
11	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
12	i.e.	i.e.	X	FW	_	_	_	_	SpaceAfter=No
13	,	,	PUNCT	,	_	_	_	_	_
14	HIV	HIV	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
15	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
16	1	1	NUM	CD	NumType=Card	_	_	_	_
17	long	long	ADJ	JJ	Degree=Pos	_	_	_	_
18	terminal	terminal	NOUN	NN	Number=Sing	_	_	_	_
19	repeats	repeat	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	SpaceAfter=No
20	)	)	PUNCT	-RRB-	_	_	_	_	_
21	via	via	ADP	IN	_	_	_	_	_
22	interaction	interaction	NOUN	NN	Number=Sing	_	_	_	_
23	with	with	ADP	IN	_	_	_	_	_
24	an	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
25	E	e	NOUN	NN	Number=Sing	_	_	_	_
26	box	box	NOUN	NN	Number=Sing	_	_	_	_
27	on	on	ADP	IN	_	_	_	_	_
28	their	they	PRON	PRP$	Number=Plur|Person=3|Poss=Yes|PronType=Prs	_	_	_	_
29	target	target	NOUN	NN	Number=Sing	_	_	_	_
30	promoters	promoter	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
31	,	,	PUNCT	,	_	_	_	_	_
32	which	which	PRON	WDT	PronType=Rel	_	_	_	_
33	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
34	also	also	ADV	RB	_	_	_	_	_
35	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
36	binding	bind	VERB	VBG	VerbForm=Ger	_	_	_	_
37	site	site	NOUN	NN	Number=Sing	_	_	_	_
38	for	for	ADP	IN	_	_	_	_	_
39	c	c	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
40	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
41	Myc	Myc	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
42	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2819
# text = The c-Myc oncoprotein is important in control of cellular proliferation and differentiation, while Yin-Yang 1 (YY1) has been shown to control the expression of a number of cellular and viral genes.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	c	c	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
3	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
4	Myc	Myc	NOUN	NN	Number=Sing	_	_	_	_
5	oncoprotein	oncoprotein	NOUN	NN	Number=Sing	_	_	_	_
6	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
7	important	important	ADJ	JJ	Degree=Pos	_	_	_	_
8	in	in	ADP	IN	_	_	_	_	_
9	control	control	NOUN	NN	Number=Sing	_	_	_	_
10	of	of	ADP	IN	_	_	_	_	_
11	cellular	cellular	ADJ	JJ	Degree=Pos	_	_	_	_
12	proliferation	proliferation	NOUN	NN	Number=Sing	_	_	_	_
13	and	and	CCONJ	CC	_	_	_	_	_
14	differentiation	differentiation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
15	,	,	PUNCT	,	_	_	_	_	_
16	while	while	SCONJ	IN	_	_	_	_	_
17	Yin	Yin	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
18	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
19	Yang	Yang	PROPN	NNP	Number=Sing	_	_	_	_
20	1	1	NUM	CD	NumType=Card	_	_	_	_
21	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
22	YY1	yy1	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
23	)	)	PUNCT	-RRB-	_	_	_	_	_
24	has	have	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
25	been	be	AUX	VBN	Tense=Past|VerbForm=Part	_	_	_	_
26	shown	show	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
27	to	to	PART	TO	_	_	_	_	_
28	control	control	VERB	VB	VerbForm=Inf	_	_	_	_
29	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
30	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
31	of	of	ADP	IN	_	_	_	_	_
32	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
33	number	number	NOUN	NN	Number=Sing	_	_	_	_
34	of	of	ADP	IN	_	_	_	_	_
35	cellular	cellular	ADJ	JJ	Degree=Pos	_	_	_	_
36	and	and	CCONJ	CC	_	_	_	_	_
37	viral	viral	ADJ	JJ	Degree=Pos	_	_	_	_
38	genes	gene	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
39	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2820
# text = These two proteins physically interact with each other and mutually inhibit their respective biological functions.
1	These	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
2	two	two	NUM	CD	NumType=Card	_	_	_	_
3	proteins	protein	NOUN	NNS	Number=Plur	_	_	_	_
4	physically	physically	ADV	RB	_	_	_	_	_
5	interact	interact	ADJ	JJ	Degree=Pos	_	_	_	_
6	with	with	ADP	IN	_	_	_	_	_
7	each	each	DET	DT	_	_	_	_	_
8	other	other	ADJ	JJ	Degree=Pos	_	_	_	_
9	and	and	CCONJ	CC	_	_	_	_	_
10	mutually	mutually	ADV	RB	_	_	_	_	_
11	inhibit	inhibit	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
12	their	they	PRON	PRP$	Number=Plur|Person=3|Poss=Yes|PronType=Prs	_	_	_	_
13	respective	respective	ADJ	JJ	Degree=Pos	_	_	_	_
14	biological	biological	ADJ	JJ	Degree=Pos	_	_	_	_
15	functions	function	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
16	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2821
# text = In this study, we show that USF/c-Myc up-regulates, while YY1 down-regulates the promoter activity of CXCR4, a coreceptor for T cell-tropic HIV-1 entry.
1	In	in	ADP	IN	_	_	_	_	_
2	this	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
3	study	study	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
4	,	,	PUNCT	,	_	_	_	_	_
5	we	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
6	show	show	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
7	that	that	SCONJ	IN	_	_	_	_	_
8	USF/	USF/	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
9	c	class	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
10	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
11	Myc	Myc	NOUN	NN	Number=Sing	_	_	_	_
12	up	up	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
13	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
14	regulates	regulate	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
15	,	,	PUNCT	,	_	_	_	_	_
16	while	while	SCONJ	IN	_	_	_	_	_
17	YY1	YY1	PRON	NN	Abbr=Yes|Number=Sing	_	_	_	_
18	down	down	ADV	RB	_	_	_	_	SpaceAfter=No
19	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
20	regulates	regulate	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
21	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
22	promoter	promoter	NOUN	NN	Number=Sing	_	_	_	_
23	activity	activity	NOUN	NN	Number=Sing	_	_	_	_
24	of	of	ADP	IN	_	_	_	_	_
25	CXCR4	CXCR4	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
26	,	,	PUNCT	,	_	_	_	_	_
27	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
28	coreceptor	coreceptor	NOUN	NN	Number=Sing	_	_	_	_
29	for	for	ADP	IN	_	_	_	_	_
30	T	t	PROPN	NNP	Number=Sing	_	_	_	_
31	cell	cell	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
32	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
33	tropic	tropic	ADJ	JJ	Degree=Pos	_	_	_	_
34	HIV	Hiv	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
35	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
36	1	1	NUM	CD	NumType=Card	_	_	_	_
37	entry	entry	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
38	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2822
# text = We have identified an E box around -260 and a YY1 binding site around -300 relative to the transcription start site.
1	We	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
2	have	have	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
3	identified	identify	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
4	an	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
5	E	e	NOUN	NN	Number=Sing	_	_	_	_
6	box	box	NOUN	NN	Number=Sing	_	_	_	_
7	around	around	ADV	RB	_	_	_	_	_
8	-	-	SYM	SYM	_	_	_	_	SpaceAfter=No
9	260	260	NUM	CD	NumType=Card	_	_	_	_
10	and	and	CCONJ	CC	_	_	_	_	_
11	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
12	YY1	yy1	NOUN	NN	Number=Sing	_	_	_	_
13	binding	bind	VERB	VBG	VerbForm=Ger	_	_	_	_
14	site	site	NOUN	NN	Number=Sing	_	_	_	_
15	around	around	ADV	RB	_	_	_	_	_
16	-	-	SYM	SYM	_	_	_	_	SpaceAfter=No
17	300	300	NUM	CD	NumType=Card	_	_	_	_
18	relative	relative	ADV	RB	_	_	_	_	_
19	to	to	ADP	IN	_	_	_	_	_
20	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
21	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
22	start	start	NOUN	NN	Number=Sing	_	_	_	_
23	site	site	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
24	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2823
# text = Mutation of the E box abolished USF/c-Myc- mediated up-regulation of CXCR4 promoter activity, and mutation of the YY1 binding site was associated with unresponsiveness to YY1-mediated inhibition.
1	Mutation	Mutation	NOUN	NN	Number=Sing	_	_	_	_
2	of	of	ADP	IN	_	_	_	_	_
3	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
4	E	e	NOUN	NN	Number=Sing	_	_	_	_
5	box	box	NOUN	NN	Number=Sing	_	_	_	_
6	abolished	abolish	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
7	USF/	USF/	ADP	IN	Abbr=Yes	_	_	_	SpaceAfter=No
8	c	c	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
9	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
10	Myc	Myc	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
11	-	-	PUNCT	HYPH	_	_	_	_	_
12	mediated	mediate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
13	up	up	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
14	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
15	regulation	regulation	NOUN	NN	Number=Sing	_	_	_	_
16	of	of	ADP	IN	_	_	_	_	_
17	CXCR4	CXCR4	NUM	CD	NumType=Card	_	_	_	_
18	promoter	promoter	NOUN	NN	Number=Sing	_	_	_	_
19	activity	activity	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
20	,	,	PUNCT	,	_	_	_	_	_
21	and	and	CCONJ	CC	_	_	_	_	_
22	mutation	mutation	NOUN	NN	Number=Sing	_	_	_	_
23	of	of	ADP	IN	_	_	_	_	_
24	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
25	YY1	YY1	NOUN	NN	Number=Sing	_	_	_	_
26	binding	binding	VERB	VBG	VerbForm=Ger	_	_	_	_
27	site	site	NOUN	NN	Number=Sing	_	_	_	_
28	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
29	associated	associate	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
30	with	with	ADP	IN	_	_	_	_	_
31	unresponsiveness	unresponsiveness	NOUN	NN	Number=Sing	_	_	_	_
32	to	to	ADP	IN	_	_	_	_	_
33	YY1	YY1	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
34	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
35	mediated	mediate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
36	inhibition	inhibition	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
37	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2824
# text = These data suggest that USF/c-Myc and YY1 may play an important role in the HIV-1-replicative cycle, by modulating both the viral fusion/entry process and viral expression.
1	These	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
2	data	data	NOUN	NN	Number=Sing	_	_	_	_
3	suggest	suggest	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
4	that	that	SCONJ	IN	_	_	_	_	_
5	USF/	Usf/	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
6	c	c	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
7	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
8	Myc	Myc	NOUN	NN	Number=Sing	_	_	_	_
9	and	and	CCONJ	CC	_	_	_	_	_
10	YY1	yy1	PRON	NN	Abbr=Yes|Number=Sing	_	_	_	_
11	may	may	AUX	MD	VerbForm=Fin	_	_	_	_
12	play	play	VERB	VB	VerbForm=Inf	_	_	_	_
13	an	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
14	important	important	ADJ	JJ	Degree=Pos	_	_	_	_
15	role	role	NOUN	NN	Number=Sing	_	_	_	_
16	in	in	ADP	IN	_	_	_	_	_
17	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
18	HIV	HIV	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
19	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
20	1	1	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
21	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
22	replicative	replicative	ADJ	JJ	Degree=Pos	_	_	_	_
23	cycle	cycle	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
24	,	,	PUNCT	,	_	_	_	_	_
25	by	by	SCONJ	IN	_	_	_	_	_
26	modulating	modulat	VERB	VBG	VerbForm=Ger	_	_	_	_
27	both	both	CCONJ	CC	_	_	_	_	_
28	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
29	viral	viral	ADJ	JJ	Degree=Pos	_	_	_	_
30	fusion	fusion	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
31	/	/	PUNCT	,	_	_	_	_	SpaceAfter=No
32	entry	entry	NOUN	NN	Number=Sing	_	_	_	_
33	process	process	NOUN	NN	Number=Sing	_	_	_	_
34	and	and	CCONJ	CC	_	_	_	_	_
35	viral	viral	ADJ	JJ	Degree=Pos	_	_	_	_
36	expression	expression	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
37	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 2825
# text = Document 003003329 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	003003329	003003329	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 2826
# text = The transcriptionally active factors mediating the effect of the HTLV-I Tax transactivator on the IL-2R alpha kappa
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	transcriptionally	transcriptionally	ADV	RB	_	_	_	_	_
3	active	active	ADJ	JJ	Degree=Pos	_	_	_	_
4	factors	factor	NOUN	NNS	Number=Plur	_	_	_	_
5	mediating	mediat	VERB	VBG	VerbForm=Ger	_	_	_	_
6	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
7	effect	effect	NOUN	NN	Number=Sing	_	_	_	_
8	of	of	ADP	IN	_	_	_	_	_
9	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
10	HTLV	HTLV	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
11	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
12	I	I	PRON	PRP	Case=Nom|Number=Sing|Person=1|PronType=Prs	_	_	_	_
13	Tax	tax	PROPN	NNP	Number=Sing	_	_	_	_
14	transactivator	transactivator	NOUN	NN	Number=Sing	_	_	_	_
15	on	on	ADP	IN	_	_	_	_	_
16	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
17	IL	Il	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
18	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
19	2R	2r	PROPN	NNP	Number=Sing	_	_	_	_
20	alpha	alpha	NOUN	NN	Number=Sing	_	_	_	_
21	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_

# sent_id = 2827
# text = B enhancer include the product of the c-rel proto-oncogene.
1	B	benefit	ADJ	JJ	Degree=Pos	_	_	_	_
2	enhancer	enhancer	NOUN	NN	Number=Sing	_	_	_	_
3	include	include	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
4	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
5	product	product	NOUN	NN	Number=Sing	_	_	_	_
6	of	of	ADP	IN	_	_	_	_	_
7	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
8	c-	c-	SYM	NFP	_	_	_	_	SpaceAfter=No
9	rel	rel	NOUN	NN	Number=Sing	_	_	_	_
10	proto	proto	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
11	-oncogene	-oncogene	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
12	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 2828
# text = The transactivator HTLV-I Tax activates the promoter of the gene coding for the interleukin 2 alpha-chain receptor (IL-2R alpha) via a kappa B site that can bind several protein species of the rel family.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	transactivator	transactivator	NOUN	NN	Number=Sing	_	_	_	_
3	HTLV	Htlv	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
4	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
5	I	I	PRON	PRP	Case=Nom|Number=Sing|Person=1|PronType=Prs	_	_	_	_
6	Tax	tax	PROPN	NNP	Number=Sing	_	_	_	_
7	activates	activate	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
8	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
9	promoter	promoter	NOUN	NN	Number=Sing	_	_	_	_
10	of	of	ADP	IN	_	_	_	_	_
11	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
12	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
13	coding	code	VERB	VBG	VerbForm=Ger	_	_	_	_
14	for	for	ADP	IN	_	_	_	_	_
15	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
16	interleukin	interleukin	NOUN	NN	Number=Sing	_	_	_	_
17	2	2	NUM	CD	NumType=Card	_	_	_	_
18	alpha	alpha	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
19	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
20	chain	chain	NOUN	NN	Number=Sing	_	_	_	_
21	receptor	receptor	NOUN	NN	Number=Sing	_	_	_	_
22	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
23	IL	Il	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
24	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
25	2R	2r	NOUN	NN	Number=Sing	_	_	_	_
26	alpha	alpha	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
27	)	)	PUNCT	-RRB-	_	_	_	_	_
28	via	via	ADP	IN	_	_	_	_	_
29	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
30	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_
31	B	b	NOUN	NN	Number=Sing	_	_	_	_
32	site	site	NOUN	NN	Number=Sing	_	_	_	_
33	that	that	PRON	WDT	PronType=Rel	_	_	_	_
34	can	can	AUX	MD	VerbForm=Fin	_	_	_	_
35	bind	bind	VERB	VB	VerbForm=Inf	_	_	_	_
36	several	several	ADJ	JJ	Degree=Pos	_	_	_	_
37	protein	protein	NOUN	NN	Number=Sing	_	_	_	_
38	species	species	NOUN	NNS	Number=Plur	_	_	_	_
39	of	of	ADP	IN	_	_	_	_	_
40	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
41	rel	rel	ADJ	JJ	Degree=Pos	_	_	_	_
42	family	family	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
43	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2829
# text = Tax1 strongly activates the enhancer activity of this motif, in both epithelial HeLa and lymphoid Jurkat cells.
1	Tax1	tax1	PROPN	NNP	Number=Sing	_	_	_	_
2	strongly	strongly	ADV	RB	_	_	_	_	_
3	activates	activate	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
4	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
5	enhancer	enhancer	NOUN	NN	Number=Sing	_	_	_	_
6	activity	activity	NOUN	NN	Number=Sing	_	_	_	_
7	of	of	ADP	IN	_	_	_	_	_
8	this	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
9	motif	motif	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
10	,	,	PUNCT	,	_	_	_	_	_
11	in	in	ADP	IN	_	_	_	_	_
12	both	both	DET	DT	_	_	_	_	_
13	epithelial	epithelial	ADJ	JJ	Degree=Pos	_	_	_	_
14	HeLa	HeLa	PROPN	NNP	Number=Sing	_	_	_	_
15	and	and	CCONJ	CC	_	_	_	_	_
16	lymphoid	lymphoid	ADJ	JJ	Degree=Pos	_	_	_	_
17	Jurkat	Jurkat	PROPN	NNP	Number=Sing	_	_	_	_
18	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
19	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2830
# text = This activation was not observed in undifferentiated embryocarcinoma F9 cells.
1	This	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
2	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
3	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
4	not	not	PART	RB	_	_	_	_	_
5	observed	observe	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
6	in	in	ADP	IN	_	_	_	_	_
7	undifferentiated	undifferentiated	ADJ	JJ	Degree=Pos	_	_	_	_
8	embryocarcinoma	embryocarcinoma	NOUN	NN	Number=Sing	_	_	_	_
9	F9	F9	NUM	CD	NumType=Card	_	_	_	_
10	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
11	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2831
# text = Overexpression of the p50, p65 and Rel proteins in these cells showed that significant activation of the IL-2R alpha kappa B site was observed only with Rel and Rel plus p65.
1	Overexpression	Overexpression	NOUN	NN	Number=Sing	_	_	_	_
2	of	of	ADP	IN	_	_	_	_	_
3	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
4	p50	p50	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
5	,	,	PUNCT	,	_	_	_	_	_
6	p65	p65	NUM	CD	NumType=Card	_	_	_	_
7	and	and	CCONJ	CC	_	_	_	_	_
8	Rel	Rel	NOUN	NN	Number=Sing	_	_	_	_
9	proteins	protein	NOUN	NNS	Number=Plur	_	_	_	_
10	in	in	ADP	IN	_	_	_	_	_
11	these	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
12	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
13	showed	show	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
14	that	that	SCONJ	IN	_	_	_	_	_
15	significant	significant	ADJ	JJ	Degree=Pos	_	_	_	_
16	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
17	of	of	ADP	IN	_	_	_	_	_
18	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
19	IL	Il	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
20	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
21	2R	2r	PROPN	NNP	Number=Sing	_	_	_	_
22	alpha	alpha	ADP	IN	_	_	_	_	_
23	kappa	kappa	PROPN	NNP	Number=Sing	_	_	_	_
24	B	b	PROPN	NNP	Number=Sing	_	_	_	_
25	site	site	NOUN	NN	Number=Sing	_	_	_	_
26	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
27	observed	observe	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
28	only	only	ADV	RB	_	_	_	_	_
29	with	with	ADP	IN	_	_	_	_	_
30	Rel	Rel	PROPN	NNP	Number=Sing	_	_	_	_
31	and	and	CCONJ	CC	_	_	_	_	_
32	Rel	Rel	PROPN	NNP	Number=Sing	_	_	_	_
33	plus	plus	ADV	RB	_	_	_	_	_
34	p65	p65	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
35	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2832
# text = Moreover, whereas both Tax and phorbol 12-myristate 13-acetate (PMA) are able to efficiently induce the binding of NF-kappa B to the IL-2R alpha kappa B site, PMA is functionally inactive.
1	Moreover	moreover	ADV	RB	_	_	_	_	SpaceAfter=No
2	,	,	PUNCT	,	_	_	_	_	_
3	whereas	whereas	SCONJ	IN	_	_	_	_	_
4	both	both	DET	DT	_	_	_	_	_
5	Tax	tax	NOUN	NN	Number=Sing	_	_	_	_
6	and	and	CCONJ	CC	_	_	_	_	_
7	phorbol	phorbol	NOUN	NN	Number=Sing	_	_	_	_
8	12	12	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
9	-	-	PUNCT	:	_	_	_	_	SpaceAfter=No
10	myristate	myristate	NOUN	NN	Number=Sing	_	_	_	_
11	13	13	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
12	-	-	PUNCT	:	_	_	_	_	SpaceAfter=No
13	acetate	acetate	NOUN	NN	Number=Sing	_	_	_	_
14	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
15	PMA	Pma	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
16	)	)	PUNCT	-RRB-	_	_	_	_	_
17	are	be	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
18	able	able	ADJ	JJ	Degree=Pos	_	_	_	_
19	to	to	PART	TO	_	_	_	_	_
20	efficiently	efficiently	ADV	RB	_	_	_	_	_
21	induce	induce	VERB	VB	VerbForm=Inf	_	_	_	_
22	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
23	binding	binding	NOUN	NN	Number=Sing	_	_	_	_
24	of	of	ADP	IN	_	_	_	_	_
25	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
26	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
27	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_
28	B	b	NOUN	NN	Number=Sing	_	_	_	_
29	to	to	ADP	IN	_	_	_	_	_
30	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
31	IL	Il	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
32	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
33	2R	2r	NOUN	NN	Number=Sing	_	_	_	_
34	alpha	alpha	NOUN	NN	Number=Sing	_	_	_	_
35	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_
36	B	b	NOUN	NN	Number=Sing	_	_	_	_
37	site	site	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
38	,	,	PUNCT	,	_	_	_	_	_
39	PMA	PMA	PROPN	NNP	Number=Sing	_	_	_	_
40	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
41	functionally	functionally	ADV	RB	_	_	_	_	_
42	inactive	inactive	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
43	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2833
# text = Using the DNA affinity precipitation assay, we observed that Tax1 is able to efficiently induce the binding of Rel, whereas PMA is not.
1	Using	use	VERB	VBG	VerbForm=Ger	_	_	_	_
2	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
3	DNA	dna	NOUN	NN	Number=Sing	_	_	_	_
4	affinity	affinity	NOUN	NN	Number=Sing	_	_	_	_
5	precipitation	precipitation	NOUN	NN	Number=Sing	_	_	_	_
6	assay	assay	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
7	,	,	PUNCT	,	_	_	_	_	_
8	we	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
9	observed	observe	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
10	that	that	SCONJ	IN	_	_	_	_	_
11	Tax1	Tax1	PROPN	NNP	Number=Sing	_	_	_	_
12	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
13	able	able	ADJ	JJ	Degree=Pos	_	_	_	_
14	to	to	PART	TO	_	_	_	_	_
15	efficiently	efficiently	ADV	RB	_	_	_	_	_
16	induce	induce	VERB	VB	VerbForm=Inf	_	_	_	_
17	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
18	binding	binding	NOUN	NN	Number=Sing	_	_	_	_
19	of	of	ADP	IN	_	_	_	_	_
20	Rel	Rel	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
21	,	,	PUNCT	,	_	_	_	_	_
22	whereas	whereas	SCONJ	IN	_	_	_	_	_
23	PMA	PMA	PROPN	NNP	Number=Sing	_	_	_	_
24	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
25	not	not	PART	RB	_	_	_	_	SpaceAfter=No
26	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2834
# text = This established a clear difference between both stimuli, indicating that Rel is the functionally active factor.
1	This	this	PRON	DT	Number=Sing|PronType=Dem	_	_	_	_
2	established	establish	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
3	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
4	clear	clear	ADJ	JJ	Degree=Pos	_	_	_	_
5	difference	difference	NOUN	NN	Number=Sing	_	_	_	_
6	between	between	ADP	IN	_	_	_	_	_
7	both	both	DET	DT	_	_	_	_	_
8	stimuli	stimuli	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
9	,	,	PUNCT	,	_	_	_	_	_
10	indicating	indicate	VERB	VBG	VerbForm=Ger	_	_	_	_
11	that	that	SCONJ	IN	_	_	_	_	_
12	Rel	Rel	PROPN	NNP	Number=Sing	_	_	_	_
13	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
14	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
15	functionally	functionally	ADV	RB	_	_	_	_	_
16	active	active	ADJ	JJ	Degree=Pos	_	_	_	_
17	factor	factor	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
18	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2835
# text = We conclude from these results that the functional activity of members of the rel family is regulated by their interaction with DNA and that Rel can be a potent transcriptional activator on specific kappa B sites.
1	We	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
2	conclude	conclude	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
3	from	from	ADP	IN	_	_	_	_	_
4	these	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
5	results	result	NOUN	NNS	Number=Plur	_	_	_	_
6	that	that	SCONJ	IN	_	_	_	_	_
7	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
8	functional	functional	ADJ	JJ	Degree=Pos	_	_	_	_
9	activity	activity	NOUN	NN	Number=Sing	_	_	_	_
10	of	of	ADP	IN	_	_	_	_	_
11	members	member	NOUN	NNS	Number=Plur	_	_	_	_
12	of	of	ADP	IN	_	_	_	_	_
13	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
14	rel	rel	ADJ	JJ	Degree=Pos	_	_	_	_
15	family	family	NOUN	NN	Number=Sing	_	_	_	_
16	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
17	regulated	regulate	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
18	by	by	ADP	IN	_	_	_	_	_
19	their	they	PRON	PRP$	Number=Plur|Person=3|Poss=Yes|PronType=Prs	_	_	_	_
20	interaction	interaction	NOUN	NN	Number=Sing	_	_	_	_
21	with	with	ADP	IN	_	_	_	_	_
22	DNA	dna	NOUN	NN	Number=Sing	_	_	_	_
23	and	and	CCONJ	CC	_	_	_	_	_
24	that	that	SCONJ	IN	_	_	_	_	_
25	Rel	Rel	PROPN	NNP	Number=Sing	_	_	_	_
26	can	can	AUX	MD	VerbForm=Fin	_	_	_	_
27	be	be	AUX	VB	VerbForm=Inf	_	_	_	_
28	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
29	potent	potent	ADJ	JJ	Degree=Pos	_	_	_	_
30	transcriptional	transcriptional	ADJ	JJ	Degree=Pos	_	_	_	_
31	activator	activator	NOUN	NN	Number=Sing	_	_	_	_
32	on	on	ADP	IN	_	_	_	_	_
33	specific	specific	ADJ	JJ	Degree=Pos	_	_	_	_
34	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_
35	B	b	NOUN	NN	Number=Sing	_	_	_	_
36	sites	site	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
37	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 2836
# text = Document 003003330 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	003003330	003003330	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 2837
# text = Phenotypic and functional studies of leukocytes in human endometrium and endometriosis.
1	Phenotypic	Phenotypic	ADJ	JJ	Degree=Pos	_	_	_	_
2	and	and	CCONJ	CC	_	_	_	_	_
3	functional	functional	ADJ	JJ	Degree=Pos	_	_	_	_
4	studies	study	NOUN	NNS	Number=Plur	_	_	_	_
5	of	of	ADP	IN	_	_	_	_	_
6	leukocytes	leukocyte	NOUN	NNS	Number=Plur	_	_	_	_
7	in	in	ADP	IN	_	_	_	_	_
8	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
9	endometrium	endometrium	NOUN	NN	Number=Sing	_	_	_	_
10	and	and	CCONJ	CC	_	_	_	_	_
11	endometriosis	endometriosis	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
12	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 2838
# text = The aetiology of endometriosis, a common and disabling disorder, is presently unknown, although immune dysfunction could allow ectopic endometrial fragments to survive outside the uterine cavity.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	aetiology	aetiology	NOUN	NN	Number=Sing	_	_	_	_
3	of	of	ADP	IN	_	_	_	_	_
4	endometriosis	endometriosis	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
5	,	,	PUNCT	,	_	_	_	_	_
6	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
7	common	common	ADJ	JJ	Degree=Pos	_	_	_	_
8	and	and	CCONJ	CC	_	_	_	_	_
9	disabling	disabl	ADJ	JJ	Degree=Pos	_	_	_	_
10	disorder	disorder	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
11	,	,	PUNCT	,	_	_	_	_	_
12	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
13	presently	presently	ADV	RB	_	_	_	_	_
14	unknown	unknown	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
15	,	,	PUNCT	,	_	_	_	_	_
16	although	although	SCONJ	IN	_	_	_	_	_
17	immune	immune	ADJ	JJ	Degree=Pos	_	_	_	_
18	dysfunction	dysfunction	NOUN	NN	Number=Sing	_	_	_	_
19	could	could	AUX	MD	VerbForm=Fin	_	_	_	_
20	allow	allow	VERB	VB	VerbForm=Inf	_	_	_	_
21	ectopic	ectopic	ADJ	JJ	Degree=Pos	_	_	_	_
22	endometrial	endometrial	ADJ	JJ	Degree=Pos	_	_	_	_
23	fragments	fragment	NOUN	NNS	Number=Plur	_	_	_	_
24	to	to	PART	TO	_	_	_	_	_
25	survive	survive	VERB	VB	VerbForm=Inf	_	_	_	_
26	outside	outside	ADP	IN	_	_	_	_	_
27	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
28	uterine	uterine	NOUN	NN	Number=Sing	_	_	_	_
29	cavity	cavity	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
30	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2839
# text = These studies investigate the relationship between leukocyte populations, steroid hormone receptor expression, proliferative activity, bcl-2 expression and apoptosis in eutopic and ectopic endometrium from women with endometriosis or adenomyosis at different phases of the menstrual cycle.
1	These	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
2	studies	study	NOUN	NNS	Number=Plur	_	_	_	_
3	investigate	investigate	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
4	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
5	relationship	relationship	NOUN	NN	Number=Sing	_	_	_	_
6	between	between	ADP	IN	_	_	_	_	_
7	leukocyte	leukocyte	NOUN	NN	Number=Sing	_	_	_	_
8	populations	population	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
9	,	,	PUNCT	,	_	_	_	_	_
10	steroid	steroid	ADJ	JJ	Degree=Pos	_	_	_	_
11	hormone	hormone	NOUN	NN	Number=Sing	_	_	_	_
12	receptor	receptor	NOUN	NN	Number=Sing	_	_	_	_
13	expression	expression	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
14	,	,	PUNCT	,	_	_	_	_	_
15	proliferative	proliferative	ADJ	JJ	Degree=Pos	_	_	_	_
16	activity	activity	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
17	,	,	PUNCT	,	_	_	_	_	_
18	bcl	bcl	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
19	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
20	2	2	NUM	CD	NumType=Card	_	_	_	_
21	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
22	and	and	CCONJ	CC	_	_	_	_	_
23	apoptosis	apoptosis	NOUN	NN	Number=Sing	_	_	_	_
24	in	in	ADP	IN	_	_	_	_	_
25	eutopic	eutopic	ADJ	JJ	Degree=Pos	_	_	_	_
26	and	and	CCONJ	CC	_	_	_	_	_
27	ectopic	ectopic	ADJ	JJ	Degree=Pos	_	_	_	_
28	endometrium	endometrium	NOUN	NN	Number=Sing	_	_	_	_
29	from	from	ADP	IN	_	_	_	_	_
30	women	woman	NOUN	NNS	Number=Plur	_	_	_	_
31	with	with	ADP	IN	_	_	_	_	_
32	endometriosis	endometriosis	NOUN	NN	Number=Sing	_	_	_	_
33	or	or	CCONJ	CC	_	_	_	_	_
34	adenomyosis	adenomyosis	NOUN	NN	Number=Sing	_	_	_	_
35	at	at	ADP	IN	_	_	_	_	_
36	different	different	ADJ	JJ	Degree=Pos	_	_	_	_
37	phases	phasis	NOUN	NNS	Number=Plur	_	_	_	_
38	of	of	ADP	IN	_	_	_	_	_
39	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
40	menstrual	menstrual	ADJ	JJ	Degree=Pos	_	_	_	_
41	cycle	cycle	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
42	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2840
# text = Significantly increased oestrogen receptor expression, bcl-2 expression and numbers of CD8+ leukocytes were found in ectopic compared with eutopic endometrium in endometriosis, and CD56+ endometrial granulated lymphocytes (eGLs) were significantly reduced in ectopic endometrium.
1	Significantly	significantly	ADV	RB	_	_	_	_	_
2	increased	increase	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
3	oestrogen	oestrogen	ADJ	JJ	Degree=Pos	_	_	_	_
4	receptor	receptor	NOUN	NN	Number=Sing	_	_	_	_
5	expression	expression	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
6	,	,	PUNCT	,	_	_	_	_	_
7	bcl	bcl	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
8	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
9	2	2	NUM	CD	NumType=Card	_	_	_	_
10	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
11	and	and	CCONJ	CC	_	_	_	_	_
12	numbers	number	NOUN	NNS	Number=Plur	_	_	_	_
13	of	of	ADP	IN	_	_	_	_	_
14	CD8	CD8	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
15	+	+	SYM	SYM	_	_	_	_	_
16	leukocytes	leukocyte	NOUN	NNS	Number=Plur	_	_	_	_
17	were	be	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
18	found	find	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
19	in	in	ADP	IN	_	_	_	_	_
20	ectopic	ectopic	ADJ	JJ	Degree=Pos	_	_	_	_
21	compared	compare	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
22	with	with	ADP	IN	_	_	_	_	_
23	eutopic	eutopic	ADJ	JJ	Degree=Pos	_	_	_	_
24	endometrium	endometrium	NOUN	NN	Number=Sing	_	_	_	_
25	in	in	ADP	IN	_	_	_	_	_
26	endometriosis	endometriosis	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
27	,	,	PUNCT	,	_	_	_	_	_
28	and	and	CCONJ	CC	_	_	_	_	_
29	CD56	CD56	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
30	+	+	SYM	SYM	_	_	_	_	_
31	endometrial	endometrial	ADJ	JJ	Degree=Pos	_	_	_	_
32	granulated	granulate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
33	lymphocytes	lymphocyte	NOUN	NNS	Number=Plur	_	_	_	_
34	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
35	eGLs	eGL	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
36	)	)	PUNCT	-RRB-	_	_	_	_	_
37	were	be	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
38	significantly	significantly	ADV	RB	_	_	_	_	_
39	reduced	reduce	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
40	in	in	ADP	IN	_	_	_	_	_
41	ectopic	ectopic	ADJ	JJ	Degree=Pos	_	_	_	_
42	endometrium	endometrium	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
43	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2841
# text = Apoptotic cells were rarely found in control and subject endometria.
1	Apoptotic	Apoptotic	ADJ	JJ	Degree=Pos	_	_	_	_
2	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
3	were	be	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
4	rarely	rarely	ADV	RB	_	_	_	_	_
5	found	find	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
6	in	in	ADP	IN	_	_	_	_	_
7	control	control	NOUN	NN	Number=Sing	_	_	_	_
8	and	and	CCONJ	CC	_	_	_	_	_
9	subject	subject	ADJ	JJ	Degree=Pos	_	_	_	_
10	endometria	endometria	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
11	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2842
# text = In contrast with endometriosis, adenomyotic lesions showed identical steroid hormone receptor expression, proliferative activity, bcl-2 expression and leukocyte subpopulations to eutopic endometrium, indicating different aetiologies for these disorders.
1	In	in	ADP	IN	_	_	_	_	_
2	contrast	contrast	NOUN	NN	Number=Sing	_	_	_	_
3	with	with	ADP	IN	_	_	_	_	_
4	endometriosis	endometriosis	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
5	,	,	PUNCT	,	_	_	_	_	_
6	adenomyotic	adenomyotic	ADJ	JJ	Degree=Pos	_	_	_	_
7	lesions	lesion	NOUN	NNS	Number=Plur	_	_	_	_
8	showed	show	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
9	identical	identical	ADJ	JJ	Degree=Pos	_	_	_	_
10	steroid	steroid	NOUN	NN	Number=Sing	_	_	_	_
11	hormone	hormone	NOUN	NN	Number=Sing	_	_	_	_
12	receptor	receptor	NOUN	NN	Number=Sing	_	_	_	_
13	expression	expression	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
14	,	,	PUNCT	,	_	_	_	_	_
15	proliferative	proliferative	ADJ	JJ	Degree=Pos	_	_	_	_
16	activity	activity	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
17	,	,	PUNCT	,	_	_	_	_	_
18	bcl	bcl	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
19	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
20	2	2	NUM	CD	NumType=Card	_	_	_	_
21	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
22	and	and	CCONJ	CC	_	_	_	_	_
23	leukocyte	leukocyte	NOUN	NN	Number=Sing	_	_	_	_
24	subpopulations	subpopulation	NOUN	NNS	Number=Plur	_	_	_	_
25	to	to	ADP	IN	_	_	_	_	_
26	eutopic	eutopic	ADJ	JJ	Degree=Pos	_	_	_	_
27	endometrium	endometrium	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
28	,	,	PUNCT	,	_	_	_	_	_
29	indicating	indicate	VERB	VBG	VerbForm=Ger	_	_	_	_
30	different	different	ADJ	JJ	Degree=Pos	_	_	_	_
31	aetiologies	aetiology	NOUN	NNS	Number=Plur	_	_	_	_
32	for	for	ADP	IN	_	_	_	_	_
33	these	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
34	disorders	disorder	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
35	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2843
# text = The unusual CD56+ CD16- eGLs present in large numbers in late secretory phase eutopic endometrium were highly purified (>98%) by immunomagnetic separation.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	unusual	unusual	ADJ	JJ	Degree=Pos	_	_	_	_
3	CD56	CD56	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
4	+	+	SYM	SYM	_	_	_	_	_
5	CD16	CD16	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
6	-	-	PUNCT	:	_	_	_	_	_
7	eGLs	eGLs	NOUN	NNS	Number=Plur	_	_	_	_
8	present	present	ADJ	JJ	Degree=Pos	_	_	_	_
9	in	in	ADP	IN	_	_	_	_	_
10	large	large	ADJ	JJ	Degree=Pos	_	_	_	_
11	numbers	number	NOUN	NNS	Number=Plur	_	_	_	_
12	in	in	ADP	IN	_	_	_	_	_
13	late	late	ADJ	JJ	Degree=Pos	_	_	_	_
14	secretory	secretory	ADJ	JJ	Degree=Pos	_	_	_	_
15	phase	phase	NOUN	NN	Number=Sing	_	_	_	_
16	eutopic	eutopic	ADJ	JJ	Degree=Pos	_	_	_	_
17	endometrium	endometrium	NOUN	NN	Number=Sing	_	_	_	_
18	were	be	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
19	highly	highly	ADV	RB	_	_	_	_	_
20	purified	purify	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
21	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
22	>98	>98	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
23	%	%	SYM	NN	Number=Sing	_	_	_	SpaceAfter=No
24	)	)	PUNCT	-RRB-	_	_	_	_	_
25	by	by	ADP	IN	_	_	_	_	_
26	immunomagnetic	immunomagnetic	ADJ	JJ	Degree=Pos	_	_	_	_
27	separation	separation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
28	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2844
# text = Except for a negligible cytotoxic activity of eGLs from early proliferative samples, cytotoxic activity of eGLs from non-pregnant endometrium during the menstrual cycle was comparable with those in peripheral blood, predominantly CD56+ CD16+ natural killer cells.
1	Except	except	VERB	VB	Mood=Imp|VerbForm=Fin	_	_	_	_
2	for	for	ADP	IN	_	_	_	_	_
3	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
4	negligible	negligible	ADJ	JJ	Degree=Pos	_	_	_	_
5	cytotoxic	cytotoxic	ADJ	JJ	Degree=Pos	_	_	_	_
6	activity	activity	NOUN	NN	Number=Sing	_	_	_	_
7	of	of	ADP	IN	_	_	_	_	_
8	eGLs	eGL	NOUN	NNS	Number=Plur	_	_	_	_
9	from	from	ADP	IN	_	_	_	_	_
10	early	early	ADJ	JJ	Degree=Pos	_	_	_	_
11	proliferative	proliferative	ADJ	JJ	Degree=Pos	_	_	_	_
12	samples	sample	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
13	,	,	PUNCT	,	_	_	_	_	_
14	cytotoxic	cytotoxic	ADJ	JJ	Degree=Pos	_	_	_	_
15	activity	activity	NOUN	NN	Number=Sing	_	_	_	_
16	of	of	ADP	IN	_	_	_	_	_
17	eGLs	eGL	NOUN	NNS	Number=Plur	_	_	_	_
18	from	from	ADP	IN	_	_	_	_	_
19	non-pregnant	non-pregnant	ADJ	JJ	Degree=Pos	_	_	_	_
20	endometrium	endometrium	NOUN	NN	Number=Sing	_	_	_	_
21	during	during	ADP	IN	_	_	_	_	_
22	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
23	menstrual	menstrual	ADJ	JJ	Degree=Pos	_	_	_	_
24	cycle	cycle	NOUN	NN	Number=Sing	_	_	_	_
25	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
26	comparable	comparable	ADJ	JJ	Degree=Pos	_	_	_	_
27	with	with	ADP	IN	_	_	_	_	_
28	those	those	PRON	DT	Number=Plur|PronType=Dem	_	_	_	_
29	in	in	ADP	IN	_	_	_	_	_
30	peripheral	peripheral	ADJ	JJ	Degree=Pos	_	_	_	_
31	blood	blood	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
32	,	,	PUNCT	,	_	_	_	_	_
33	predominantly	predominantly	ADV	RB	_	_	_	_	_
34	CD56	CD56	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
35	+	+	SYM	SYM	_	_	_	_	_
36	CD	cd	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
37	16	16	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
38	+	+	SYM	SYM	_	_	_	_	_
39	natural	natural	ADJ	JJ	Degree=Pos	_	_	_	_
40	killer	killer	NOUN	NN	Number=Sing	_	_	_	_
41	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
42	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2845
# text = eGLs from non-pregnant endometrium and early pregnancy showed a variable proliferative response to 5 and 100 U/ml interleukin-2 over 48-h and 120-h time courses.
1	eGLs	eGL	NOUN	NNS	Number=Plur	_	_	_	_
2	from	from	ADP	IN	_	_	_	_	_
3	non-pregnant	non-pregnant	ADJ	JJ	Degree=Pos	_	_	_	_
4	endometrium	endometrium	NOUN	NN	Number=Sing	_	_	_	_
5	and	and	CCONJ	CC	_	_	_	_	_
6	early	early	ADJ	JJ	Degree=Pos	_	_	_	_
7	pregnancy	pregnancy	NOUN	NN	Number=Sing	_	_	_	_
8	showed	show	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
9	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
10	variable	variable	ADJ	JJ	Degree=Pos	_	_	_	_
11	proliferative	proliferative	ADJ	JJ	Degree=Pos	_	_	_	_
12	response	response	NOUN	NN	Number=Sing	_	_	_	_
13	to	to	ADP	IN	_	_	_	_	_
14	5	5	NUM	CD	NumType=Card	_	_	_	_
15	and	and	CCONJ	CC	_	_	_	_	_
16	100	100	NUM	CD	NumType=Card	_	_	_	_
17	U/	Uith	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
18	ml	ml	NOUN	NN	Number=Sing	_	_	_	_
19	interleukin	interleukin	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
20	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
21	2	2	NUM	CD	NumType=Card	_	_	_	_
22	over	over	ADP	IN	_	_	_	_	_
23	48	48	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
24	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
25	h	h	NOUN	NN	Number=Sing	_	_	_	_
26	and	and	CCONJ	CC	_	_	_	_	_
27	120	120	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
28	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
29	h	h	NOUN	NN	Number=Sing	_	_	_	_
30	time	time	NOUN	NN	Number=Sing	_	_	_	_
31	courses	course	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
32	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2846
# text = eGLs are evidently functionally important in the eutopic endometrium.
1	eGLs	eGL	NOUN	NNS	Number=Plur	_	_	_	_
2	are	be	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
3	evidently	evidently	ADV	RB	_	_	_	_	_
4	functionally	functionally	ADV	RB	_	_	_	_	_
5	important	important	ADJ	JJ	Degree=Pos	_	_	_	_
6	in	in	ADP	IN	_	_	_	_	_
7	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
8	eutopic	eutopic	ADJ	JJ	Degree=Pos	_	_	_	_
9	endometrium	endometrium	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
10	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2847
# text = Their absence in endometriotic lesions together with increased CD+8 T-cell numbers and increased oestrogen receptor and bcl-2 expression may have significant effects on the development and progression of endometriosis.
1	Their	they	PRON	PRP$	Number=Plur|Person=3|Poss=Yes|PronType=Prs	_	_	_	_
2	absence	absence	NOUN	NN	Number=Sing	_	_	_	_
3	in	in	ADP	IN	_	_	_	_	_
4	endometriotic	endometriotic	ADJ	JJ	Degree=Pos	_	_	_	_
5	lesions	lesion	NOUN	NNS	Number=Plur	_	_	_	_
6	together	together	ADV	RB	_	_	_	_	_
7	with	with	ADP	IN	_	_	_	_	_
8	increased	increase	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
9	CD	cd	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
10	+	+	SYM	SYM	_	_	_	_	SpaceAfter=No
11	8	8	NUM	CD	NumType=Card	_	_	_	_
12	T-	T-	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
13	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
14	numbers	number	NOUN	NNS	Number=Plur	_	_	_	_
15	and	and	CCONJ	CC	_	_	_	_	_
16	increased	increase	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
17	oestrogen	oestrogen	ADJ	JJ	Degree=Pos	_	_	_	_
18	receptor	receptor	NOUN	NN	Number=Sing	_	_	_	_
19	and	and	CCONJ	CC	_	_	_	_	_
20	bcl	bcl	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
21	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
22	2	2	NUM	CD	NumType=Card	_	_	_	_
23	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
24	may	may	AUX	MD	VerbForm=Fin	_	_	_	_
25	have	have	VERB	VB	VerbForm=Inf	_	_	_	_
26	significant	significant	ADJ	JJ	Degree=Pos	_	_	_	_
27	effects	effect	NOUN	NNS	Number=Plur	_	_	_	_
28	on	on	ADP	IN	_	_	_	_	_
29	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
30	development	development	NOUN	NN	Number=Sing	_	_	_	_
31	and	and	CCONJ	CC	_	_	_	_	_
32	progression	progression	NOUN	NN	Number=Sing	_	_	_	_
33	of	of	ADP	IN	_	_	_	_	_
34	endometriosis	endometriosis	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
35	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 2848
# text = Document 003003333 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	003003333	003003333	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 2849
# text = Constitutive activation of an epithelial signal transducer and activator of transcription (STAT) pathway in asthma.
1	Constitutive	Constitutive	ADJ	JJ	Degree=Pos	_	_	_	_
2	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
3	of	of	ADP	IN	_	_	_	_	_
4	an	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
5	epithelial	epithelial	ADJ	JJ	Degree=Pos	_	_	_	_
6	signal	signal	NOUN	NN	Number=Sing	_	_	_	_
7	transducer	transducer	NOUN	NN	Number=Sing	_	_	_	_
8	and	and	CCONJ	CC	_	_	_	_	_
9	activator	activator	NOUN	NN	Number=Sing	_	_	_	_
10	of	of	ADP	IN	_	_	_	_	_
11	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
12	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
13	STAT	STAT	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
14	)	)	PUNCT	-RRB-	_	_	_	_	_
15	pathway	pathway	NOUN	NN	Number=Sing	_	_	_	_
16	in	in	ADP	IN	_	_	_	_	_
17	asthma	asthma	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
18	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 2850
# text = Cytokine effects on immunity and inflammation often depend on the transcription factors termed signal transducers and activators of transcription (STATs), so STAT signaling pathways are candidates for influencing inflammatory disease.
1	Cytokine	Cytokine	VERB	VB	Mood=Imp|VerbForm=Fin	_	_	_	_
2	effects	effect	NOUN	NNS	Number=Plur	_	_	_	_
3	on	on	ADP	IN	_	_	_	_	_
4	immunity	immunity	NOUN	NN	Number=Sing	_	_	_	_
5	and	and	CCONJ	CC	_	_	_	_	_
6	inflammation	inflammation	NOUN	NN	Number=Sing	_	_	_	_
7	often	often	ADV	RB	_	_	_	_	_
8	depend	depend	VERB	VB	Typo=Yes|VerbForm=Inf	_	_	_	_
9	on	on	ADP	IN	_	_	_	_	_
10	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
11	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
12	factors	factor	NOUN	NNS	Number=Plur	_	_	_	_
13	termed	term	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
14	signal	signal	ADJ	JJ	Degree=Pos	_	_	_	_
15	transducers	transducer	NOUN	NNS	Number=Plur	_	_	_	_
16	and	and	CCONJ	CC	_	_	_	_	_
17	activators	activator	NOUN	NNS	Number=Plur	_	_	_	_
18	of	of	ADP	IN	_	_	_	_	_
19	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
20	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
21	STATs	STATs	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
22	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
23	,	,	PUNCT	,	_	_	_	_	_
24	so	so	ADV	RB	_	_	_	_	_
25	STAT	Stat	ADJ	JJ	Degree=Pos	_	_	_	_
26	signaling	signaling	NOUN	NN	Number=Sing	_	_	_	_
27	pathways	pathway	NOUN	NNS	Number=Plur	_	_	_	_
28	are	be	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
29	candidates	candidate	NOUN	NNS	Number=Plur	_	_	_	_
30	for	for	SCONJ	IN	_	_	_	_	_
31	influencing	influence	VERB	VBG	VerbForm=Ger	_	_	_	_
32	inflammatory	inflammatory	ADJ	JJ	Degree=Pos	_	_	_	_
33	disease	disease	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
34	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2851
# text = We reasoned that selective IFN responsiveness of the first STAT family member (Stat1) and Stat1-dependent immune-response genes such as intercellular adhesion molecule-1 (ICAM-1), IFN regulatory factor-1 (IRF-1), and Stat1 itself in airway epithelial cells provides a basis for detecting cytokine signaling abnormalities in inflammatory airway disease.
1	We	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
2	reasoned	reason	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
3	that	that	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
4	selective	selective	ADJ	JJ	Degree=Pos	_	_	_	_
5	IFN	Ifn	NOUN	NN	Number=Sing	_	_	_	_
6	responsiveness	responsiveness	NOUN	NN	Number=Sing	_	_	_	_
7	of	of	ADP	IN	_	_	_	_	_
8	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
9	first	first	ADJ	JJ	Degree=Pos|NumType=Ord	_	_	_	_
10	STAT	Stat	NOUN	NN	Number=Sing	_	_	_	_
11	family	family	NOUN	NN	Number=Sing	_	_	_	_
12	member	member	NOUN	NN	Number=Sing	_	_	_	_
13	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
14	Stat1	Stat1	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
15	)	)	PUNCT	-RRB-	_	_	_	_	_
16	and	and	CCONJ	CC	_	_	_	_	_
17	Stat1	Stat1	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
18	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
19	dependent	dependent	ADJ	JJ	Degree=Pos	_	_	_	_
20	immune	immune	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
21	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
22	response	response	NOUN	NN	Number=Sing	_	_	_	_
23	genes	gene	NOUN	NNS	Number=Plur	_	_	_	_
24	such	such	ADJ	JJ	Degree=Pos	_	_	_	_
25	as	as	ADP	IN	_	_	_	_	_
26	intercellular	intercellular	ADJ	JJ	Degree=Pos	_	_	_	_
27	adhesion	adhesion	NOUN	NN	Number=Sing	_	_	_	_
28	molecule	molecule	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
29	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
30	1	1	NUM	CD	NumType=Card	_	_	_	_
31	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
32	ICAM	ICAm	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
33	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
34	1	1	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
35	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
36	,	,	PUNCT	,	_	_	_	_	_
37	IFN	Ifn	PROPN	NNP	Number=Sing	_	_	_	_
38	regulatory	regulatory	ADJ	JJ	Degree=Pos	_	_	_	_
39	factor	factor	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
40	-1	-1	NUM	CD	NumType=Card	_	_	_	_
41	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
42	IRF	Irf	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
43	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
44	1	1	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
45	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
46	,	,	PUNCT	,	_	_	_	_	_
47	and	and	CCONJ	CC	_	_	_	_	_
48	Stat1	Stat1	PROPN	NNP	Number=Sing	_	_	_	_
49	itself	itself	PRON	PRP	Gender=Neut|Number=Sing|Person=3|PronType=Prs	_	_	_	_
50	in	in	ADP	IN	_	_	_	_	_
51	airway	airway	ADJ	JJ	Degree=Pos	_	_	_	_
52	epithelial	epithelial	ADJ	JJ	Degree=Pos	_	_	_	_
53	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
54	provides	provides	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
55	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
56	basis	basis	NOUN	NN	Number=Sing	_	_	_	_
57	for	for	SCONJ	IN	_	_	_	_	_
58	detecting	detect	VERB	VBG	VerbForm=Ger	_	_	_	_
59	cytokine	cytokine	NOUN	NN	Number=Sing	_	_	_	_
60	signaling	signal	VERB	VBG	VerbForm=Ger	_	_	_	_
61	abnormalities	abnormality	NOUN	NNS	Number=Plur	_	_	_	_
62	in	in	ADP	IN	_	_	_	_	_
63	inflammatory	inflammatory	ADJ	JJ	Degree=Pos	_	_	_	_
64	airway	airway	NOUN	NN	Number=Sing	_	_	_	_
65	disease	disease	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
66	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2852
# text = On the basis of nuclear localization and phosphorylation, we found that epithelial Stat1 (but not other control transcription factors) was invariably activated in asthmatic compared with normal control or chronic bronchitis subjects.
1	On	on	ADP	IN	_	_	_	_	_
2	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
3	basis	basis	NOUN	NN	Number=Sing	_	_	_	_
4	of	of	ADP	IN	_	_	_	_	_
5	nuclear	nuclear	ADJ	JJ	Degree=Pos	_	_	_	_
6	localization	localization	NOUN	NN	Number=Sing	_	_	_	_
7	and	and	CCONJ	CC	_	_	_	_	_
8	phosphorylation	phosphorylation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
9	,	,	PUNCT	,	_	_	_	_	_
10	we	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
11	found	find	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
12	that	that	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
13	epithelial	epithelial	ADJ	JJ	Degree=Pos	_	_	_	_
14	Stat1	Stat1	NOUN	NN	Number=Sing	_	_	_	_
15	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
16	but	but	CCONJ	CC	_	_	_	_	_
17	not	not	ADV	RB	_	_	_	_	_
18	other	other	ADJ	JJ	Degree=Pos	_	_	_	_
19	control	control	NOUN	NN	Number=Sing	_	_	_	_
20	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
21	factors	factor	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
22	)	)	PUNCT	-RRB-	_	_	_	_	_
23	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
24	invariably	invariably	ADV	RB	_	_	_	_	_
25	activated	activate	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
26	in	in	ADP	IN	_	_	_	_	_
27	asthmatic	asthmatic	ADJ	JJ	Degree=Pos	_	_	_	_
28	compared	compare	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
29	with	with	ADP	IN	_	_	_	_	_
30	normal	normal	ADJ	JJ	Degree=Pos	_	_	_	_
31	control	control	NOUN	NN	Number=Sing	_	_	_	_
32	or	or	CCONJ	CC	_	_	_	_	_
33	chronic	chronic	ADJ	JJ	Degree=Pos	_	_	_	_
34	bronchitis	bronchitis	NOUN	NN	Number=Sing	_	_	_	_
35	subjects	subject	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
36	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2853
# text = Furthermore, epithelial levels of activated Stat1 correlated with levels of expression for epithelial ICAM-1, IRF-1, and Stat1, and in turn, ICAM-1 levels correlated with T-cell accumulation in tissue.
1	Furthermore	furthermore	ADV	RB	_	_	_	_	SpaceAfter=No
2	,	,	PUNCT	,	_	_	_	_	_
3	epithelial	epithelial	ADJ	JJ	Degree=Pos	_	_	_	_
4	levels	level	NOUN	NNS	Number=Plur	_	_	_	_
5	of	of	ADP	IN	_	_	_	_	_
6	activated	activate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
7	Stat1	stat1	PROPN	NNP	Number=Sing	_	_	_	_
8	correlated	correlate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
9	with	with	ADP	IN	_	_	_	_	_
10	levels	level	NOUN	NNS	Number=Plur	_	_	_	_
11	of	of	ADP	IN	_	_	_	_	_
12	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
13	for	for	ADP	IN	_	_	_	_	_
14	epithelial	epithelial	ADJ	JJ	Degree=Pos	_	_	_	_
15	ICAM	ICAm	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
16	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
17	1	1	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
18	,	,	PUNCT	,	_	_	_	_	_
19	IRF	IRF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
20	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
21	1	1	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
22	,	,	PUNCT	,	_	_	_	_	_
23	and	and	CCONJ	CC	_	_	_	_	_
24	Stat1	Stat1	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
25	,	,	PUNCT	,	_	_	_	_	_
26	and	and	CCONJ	CC	_	_	_	_	_
27	in	in	ADP	IN	_	_	_	_	_
28	turn	turn	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
29	,	,	PUNCT	,	_	_	_	_	_
30	ICAM	ICAm	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
31	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
32	1	1	NUM	CD	NumType=Card	_	_	_	_
33	levels	level	NOUN	NNS	Number=Plur	_	_	_	_
34	correlated	correlate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
35	with	with	ADP	IN	_	_	_	_	_
36	T-	t-	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
37	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
38	accumulation	accumulation	NOUN	NN	Number=Sing	_	_	_	_
39	in	in	ADP	IN	_	_	_	_	_
40	tissue	tissue	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
41	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2854
# text = However, only low levels of IFN-gamma or IFN-gamma-producing cells were detected in airway tissue in all subjects.
1	However	however	ADV	RB	_	_	_	_	SpaceAfter=No
2	,	,	PUNCT	,	_	_	_	_	_
3	only	only	ADV	RB	_	_	_	_	_
4	low	low	ADJ	JJ	Degree=Pos	_	_	_	_
5	levels	level	NOUN	NNS	Number=Plur	_	_	_	_
6	of	of	ADP	IN	_	_	_	_	_
7	IFN	IFN	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
8	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
9	gamma	gamma	NOUN	NN	Number=Sing	_	_	_	_
10	or	or	CCONJ	CC	_	_	_	_	_
11	IFN-	IFN-	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
12	gamma	gamma	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
13	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
14	producing	producing	VERB	VBG	VerbForm=Ger	_	_	_	_
15	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
16	were	be	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
17	detected	detect	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
18	in	in	ADP	IN	_	_	_	_	_
19	airway	airway	NOUN	NN	Number=Sing	_	_	_	_
20	tissue	tissue	NOUN	NN	Number=Sing	_	_	_	_
21	in	in	ADP	IN	_	_	_	_	_
22	all	all	DET	DT	_	_	_	_	_
23	subjects	subjects	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
24	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2855
# text = The results therefore provide initial evidence linking abnormal behavior of STAT pathways for cytokine signaling to the development of an inflammatory disease.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	results	result	NOUN	NNS	Number=Plur	_	_	_	_
3	therefore	therefore	ADV	RB	_	_	_	_	_
4	provide	provide	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
5	initial	initial	ADJ	JJ	Degree=Pos	_	_	_	_
6	evidence	evidence	NOUN	NN	Number=Sing	_	_	_	_
7	linking	link	VERB	VBG	VerbForm=Ger	_	_	_	_
8	abnormal	abnormal	ADJ	JJ	Degree=Pos	_	_	_	_
9	behavior	behavior	NOUN	NN	Number=Sing	_	_	_	_
10	of	of	ADP	IN	_	_	_	_	_
11	STAT	Stat	ADJ	JJ	Degree=Pos	_	_	_	_
12	pathways	pathway	NOUN	NNS	Number=Plur	_	_	_	_
13	for	for	ADP	IN	_	_	_	_	_
14	cytokine	cytokine	NOUN	NN	Number=Sing	_	_	_	_
15	signaling	signal	NOUN	NN	Number=Sing	_	_	_	_
16	to	to	ADP	IN	_	_	_	_	_
17	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
18	development	development	NOUN	NN	Number=Sing	_	_	_	_
19	of	of	ADP	IN	_	_	_	_	_
20	an	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
21	inflammatory	inflammatory	ADJ	JJ	Degree=Pos	_	_	_	_
22	disease	disease	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
23	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2856
# text = In that context, the results also change the current scheme for asthma pathogenesis to one that must include a localized gain in transcriptional signal ordinarily used for a T helper 1-type cytokine (IFN-gamma) in combination with allergy-driven overproduction of T helper 2-type cytokines.
1	In	in	ADP	IN	_	_	_	_	_
2	that	that	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
3	context	context	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
4	,	,	PUNCT	,	_	_	_	_	_
5	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
6	results	result	NOUN	NNS	Number=Plur	_	_	_	_
7	also	also	ADV	RB	_	_	_	_	_
8	change	change	VERB	VB	VerbForm=Inf	_	_	_	_
9	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
10	current	current	ADJ	JJ	Degree=Pos	_	_	_	_
11	scheme	scheme	NOUN	NN	Number=Sing	_	_	_	_
12	for	for	ADP	IN	_	_	_	_	_
13	asthma	asthma	NOUN	NN	Number=Sing	_	_	_	_
14	pathogenesis	pathogenesis	NOUN	NN	Number=Sing	_	_	_	_
15	to	to	ADP	IN	_	_	_	_	_
16	one	one	NUM	CD	NumType=Card	_	_	_	_
17	that	that	PRON	WDT	PronType=Rel	_	_	_	_
18	must	must	AUX	MD	VerbForm=Fin	_	_	_	_
19	include	include	VERB	VB	VerbForm=Inf	_	_	_	_
20	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
21	localized	localize	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
22	gain	gain	NOUN	NN	Number=Sing	_	_	_	_
23	in	in	ADP	IN	_	_	_	_	_
24	transcriptional	transcriptional	ADJ	JJ	Degree=Pos	_	_	_	_
25	signal	signal	NOUN	NN	Number=Sing	_	_	_	_
26	ordinarily	ordinarily	ADV	RB	_	_	_	_	_
27	used	use	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
28	for	for	ADP	IN	_	_	_	_	_
29	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
30	T	T	PROPN	NNP	Number=Sing	_	_	_	_
31	helper	helper	NOUN	NN	Number=Sing	_	_	_	_
32	1	1	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
33	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
34	type	type	NOUN	NN	Number=Sing	_	_	_	_
35	cytokine	cytokine	NOUN	NN	Number=Sing	_	_	_	_
36	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
37	IFN	Ifn	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
38	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
39	gamma	gamma	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
40	)	)	PUNCT	-RRB-	_	_	_	_	_
41	in	in	ADP	IN	_	_	_	_	_
42	combination	combination	NOUN	NN	Number=Sing	_	_	_	_
43	with	with	ADP	IN	_	_	_	_	_
44	allergy	allergy	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
45	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
46	driven	driven	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
47	overproduction	overproduction	NOUN	NN	Number=Sing	_	_	_	_
48	of	of	ADP	IN	_	_	_	_	_
49	T	T	PROPN	NNP	Number=Sing	_	_	_	_
50	helper	helper	NOUN	NN	Number=Sing	_	_	_	_
51	2	2	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
52	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
53	type	type	NOUN	NN	Number=Sing	_	_	_	_
54	cytokines	cytokine	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
55	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 2857
# text = Document 003003335 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	003003335	003003335	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 2858
# text = Protein kinase B (c-Akt), phosphatidylinositol 3-kinase, and STAT5 are activated by erythropoietin (EPO) in HCD57 erythroid cells but are constitutively active in an EPO-independent, apoptosis-resistant subclone (HCD57-SREI cells).
1	Protein	protein	NOUN	NN	Number=Sing	_	_	_	_
2	kinase	kinase	NOUN	NN	Number=Sing	_	_	_	_
3	B	b	NOUN	NN	Number=Sing	_	_	_	_
4	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
5	c	c	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
6	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
7	Akt	Akt	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
8	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
9	,	,	PUNCT	,	_	_	_	_	_
10	phosphatidylinositol	phosphatidylinositol	INTJ	UH	_	_	_	_	_
11	3	3	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
12	-	-	PUNCT	:	_	_	_	_	SpaceAfter=No
13	kinase	kinase	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
14	,	,	PUNCT	,	_	_	_	_	_
15	and	and	CCONJ	CC	_	_	_	_	_
16	STAT5	stat5	PROPN	NNP	Number=Sing	_	_	_	_
17	are	be	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
18	activated	activate	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
19	by	by	ADP	IN	_	_	_	_	_
20	erythropoietin	erythropoietin	NOUN	NN	Number=Sing	_	_	_	_
21	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
22	EPO	EPO	INTJ	UH	_	_	_	_	SpaceAfter=No
23	)	)	PUNCT	-RRB-	_	_	_	_	_
24	in	in	ADP	IN	_	_	_	_	_
25	HCD57	HCD57	NUM	CD	NumType=Card	_	_	_	_
26	erythroid	erythroid	ADJ	JJ	Degree=Pos	_	_	_	_
27	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
28	but	but	CCONJ	CC	_	_	_	_	_
29	are	be	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
30	constitutively	constitutively	ADV	RB	_	_	_	_	_
31	active	active	ADJ	JJ	Degree=Pos	_	_	_	_
32	in	in	ADP	IN	_	_	_	_	_
33	an	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
34	EPO	EPO	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
35	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
36	independent	independent	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
37	,	,	PUNCT	,	_	_	_	_	_
38	apoptosis	apoptosis	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
39	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
40	resistant	resistant	NOUN	NN	Number=Sing	_	_	_	_
41	subclone	subclone	NOUN	NN	Number=Sing	_	_	_	_
42	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
43	HCD57-	HCD57-	SYM	SYM	_	_	_	_	SpaceAfter=No
44	SREI	Srei	NUM	CD	NumType=Card	_	_	_	_
45	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
46	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
47	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 2859
# text = We found that erythropoietin (EPO) and stem cell factor (SCF) activated protein kinase B (PKB/Akt) in EPO-dependent HCD57 erythroid cells.
1	We	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
2	found	find	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
3	that	that	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
4	erythropoietin	erythropoietin	NOUN	NN	Number=Sing	_	_	_	_
5	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
6	EPO	EPO	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
7	)	)	PUNCT	-RRB-	_	_	_	_	_
8	and	and	CCONJ	CC	_	_	_	_	_
9	stem	stem	NOUN	NN	Number=Sing	_	_	_	_
10	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
11	factor	factor	NOUN	NN	Number=Sing	_	_	_	_
12	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
13	SCF	SCF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
14	)	)	PUNCT	-RRB-	_	_	_	_	_
15	activated	activate	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
16	protein	protein	NOUN	NN	Number=Sing	_	_	_	_
17	kinase	kinase	NOUN	NN	Number=Sing	_	_	_	_
18	B	b	PROPN	NNP	Number=Sing	_	_	_	_
19	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
20	PKB	PKB	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
21	/	/	PUNCT	,	_	_	_	_	SpaceAfter=No
22	Akt	Akt	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
23	)	)	PUNCT	-RRB-	_	_	_	_	_
24	in	in	ADP	IN	_	_	_	_	_
25	EPO	EPO	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
26	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
27	dependent	dependent	ADJ	JJ	Degree=Pos	_	_	_	_
28	HCD57	HCD57	NUM	CD	NumType=Card	_	_	_	_
29	erythroid	erythroid	ADJ	JJ	Degree=Pos	_	_	_	_
30	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
31	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2860
# text = To better understand signals controlling proliferation and viability, erythroid cells that resist apoptosis in the absence of EPO were subcloned and characterized (HCD57-SREI cells).
1	To	to	ADP	IN	_	_	_	_	_
2	better	better	ADJ	JJR	Degree=Cmp	_	_	_	_
3	understand	understand	ADJ	JJ	Degree=Pos	_	_	_	_
4	signals	signal	NOUN	NNS	Number=Plur	_	_	_	_
5	controlling	control	VERB	VBG	VerbForm=Ger	_	_	_	_
6	proliferation	proliferation	NOUN	NN	Number=Sing	_	_	_	_
7	and	and	CCONJ	CC	_	_	_	_	_
8	viability	viability	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
9	,	,	PUNCT	,	_	_	_	_	_
10	erythroid	erythroid	ADJ	JJ	Degree=Pos	_	_	_	_
11	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
12	that	that	PRON	WDT	PronType=Rel	_	_	_	_
13	resist	resist	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
14	apoptosis	apoptosis	NOUN	NN	Number=Sing	_	_	_	_
15	in	in	ADP	IN	_	_	_	_	_
16	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
17	absence	absence	NOUN	NN	Number=Sing	_	_	_	_
18	of	of	ADP	IN	_	_	_	_	_
19	EPO	EPO	PROPN	NNP	Number=Sing	_	_	_	_
20	were	be	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
21	subcloned	subclon	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
22	and	and	CCONJ	CC	_	_	_	_	_
23	characterized	characterize	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
24	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
25	HCD57-	HCD57-	SYM	NFP	_	_	_	_	SpaceAfter=No
26	SREI	SREI	ADJ	JJ	Degree=Pos	_	_	_	_
27	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
28	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
29	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2861
# text = Constitutive activations of PKB/Akt, STAT5a, and STAT5b were noted in these EPO-independent cells.
1	Constitutive	Constitutive	ADJ	JJ	Degree=Pos	_	_	_	_
2	activations	activation	NOUN	NNS	Number=Plur	_	_	_	_
3	of	of	ADP	IN	_	_	_	_	_
4	PKB	PKB	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
5	/	/	PUNCT	,	_	_	_	_	SpaceAfter=No
6	Akt	Akt	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
7	,	,	PUNCT	,	_	_	_	_	_
8	STAT5a	STAT5a	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
9	,	,	PUNCT	,	_	_	_	_	_
10	and	and	CCONJ	CC	_	_	_	_	_
11	STAT5	STAT5	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
12	b	b	NOUN	NN	Number=Sing	_	_	_	_
13	were	be	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
14	noted	note	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
15	in	in	ADP	IN	_	_	_	_	_
16	these	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
17	EPO	Epo	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
18	-independent	-independent	ADJ	JJ	Degree=Pos	_	_	_	_
19	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
20	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2862
# text = PI3-kinase activity was an upstream activator of PKB/Akt because the PI3-kinase inhibitor LY294002 blocked both constitutive PKB/Akt and factor-dependent PKB/Akt activity.
1	PI3	PI3	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
2	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
3	kinase	kinase	NOUN	NN	Number=Sing	_	_	_	_
4	activity	activity	NOUN	NN	Number=Sing	_	_	_	_
5	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
6	an	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
7	upstream	upstream	ADJ	JJ	Degree=Pos	_	_	_	_
8	activator	activator	NOUN	NN	Number=Sing	_	_	_	_
9	of	of	ADP	IN	_	_	_	_	_
10	PKB	PKB	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
11	/	/	PUNCT	,	_	_	_	_	SpaceAfter=No
12	Akt	Akt	PROPN	NNP	Number=Sing	_	_	_	_
13	because	because	SCONJ	IN	_	_	_	_	_
14	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
15	PI3	PI3	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
16	-kinase	-kinase	NOUN	NN	Number=Sing	_	_	_	_
17	inhibitor	inhibitor	NOUN	NN	Number=Sing	_	_	_	_
18	LY294002	LY294002	NUM	CD	NumType=Card	_	_	_	_
19	blocked	block	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
20	both	both	DET	DT	_	_	_	_	_
21	constitutive	constitutive	ADJ	JJ	Degree=Pos	_	_	_	_
22	PKB	Pkb	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
23	/	/	PUNCT	,	_	_	_	_	SpaceAfter=No
24	Akt	Akt	PROPN	NNP	Number=Sing	_	_	_	_
25	and	and	CCONJ	CC	_	_	_	_	_
26	factor-dependent	factor-dependent	ADJ	JJ	Degree=Pos	_	_	_	_
27	PKB	PKB	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
28	/	/	PUNCT	,	_	_	_	_	SpaceAfter=No
29	Akt	Akt	PROPN	NNP	Number=Sing	_	_	_	_
30	activity	activity	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
31	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2863
# text = The LY294002 study showed that proliferation and viability of both HCD57-SREI and HCD57 cells correlated with the activity of PKB/Akt; however, PKB/Akt activity alone did not protect these cells from apoptosis.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	LY294002	Ly294002	NUM	CD	NumType=Card	_	_	_	_
3	study	study	NOUN	NN	Number=Sing	_	_	_	_
4	showed	show	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
5	that	that	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
6	proliferation	proliferation	NOUN	NN	Number=Sing	_	_	_	_
7	and	and	CCONJ	CC	_	_	_	_	_
8	viability	viability	NOUN	NN	Number=Sing	_	_	_	_
9	of	of	ADP	IN	_	_	_	_	_
10	both	both	CCONJ	CC	_	_	_	_	_
11	HCD57-SREI	HCD57-SREI	NUM	CD	NumType=Card	_	_	_	_
12	and	and	CCONJ	CC	_	_	_	_	_
13	HCD57	HCD57	NUM	CD	NumType=Card	_	_	_	_
14	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
15	correlated	correlate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
16	with	with	ADP	IN	_	_	_	_	_
17	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
18	activity	activity	NOUN	NN	Number=Sing	_	_	_	_
19	of	of	ADP	IN	_	_	_	_	_
20	PKB	PKB	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
21	/	/	PUNCT	,	_	_	_	_	SpaceAfter=No
22	Akt	Akt	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
23	;	;	PUNCT	,	_	_	_	_	_
24	however	however	ADV	RB	_	_	_	_	SpaceAfter=No
25	,	,	PUNCT	,	_	_	_	_	_
26	PKB	PKB	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
27	/	/	PUNCT	,	_	_	_	_	SpaceAfter=No
28	Akt	Akt	PROPN	NNP	Number=Sing	_	_	_	_
29	activity	activity	NOUN	NN	Number=Sing	_	_	_	_
30	alone	alone	ADV	RB	_	_	_	_	_
31	did	do	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
32	not	not	PART	RB	_	_	_	_	_
33	protect	protect	VERB	VB	VerbForm=Inf	_	_	_	_
34	these	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
35	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
36	from	from	ADP	IN	_	_	_	_	_
37	apoptosis	apoptosis	PRON	DT	Number=Sing|PronType=Dem	_	_	_	SpaceAfter=No
38	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2864
# text = Treatment of HCD57 cells with SCF also activated PKB/Akt, but did not protect from apoptosis.
1	Treatment	treatment	NOUN	NN	Number=Sing	_	_	_	_
2	of	of	ADP	IN	_	_	_	_	_
3	HCD57	HCD57	NUM	CD	NumType=Card	_	_	_	_
4	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
5	with	with	ADP	IN	_	_	_	_	_
6	SCF	SCF	PROPN	NNP	Number=Sing	_	_	_	_
7	also	also	ADV	RB	_	_	_	_	_
8	activated	activate	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
9	PKB	PKB	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
10	/	/	PUNCT	,	_	_	_	_	SpaceAfter=No
11	Akt	Akt	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
12	,	,	PUNCT	,	_	_	_	_	_
13	but	but	CCONJ	CC	_	_	_	_	_
14	did	do	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
15	not	not	PART	RB	_	_	_	_	_
16	protect	protect	VERB	VB	VerbForm=Inf	_	_	_	_
17	from	from	ADP	IN	_	_	_	_	_
18	apoptosis	apoptosis	PRON	DT	Number=Sing|PronType=Dem	_	_	_	SpaceAfter=No
19	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2865
# text = This result suggested that PKB/PI3-kinase activity is necessary but not sufficient to promote viability and/or proliferation.
1	This	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
2	result	result	NOUN	NN	Number=Sing	_	_	_	_
3	suggested	suggest	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
4	that	that	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
5	PKB	Pkb	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
6	/	/	PUNCT	,	_	_	_	_	SpaceAfter=No
7	PI3	PI3	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
8	-kinase	-kinase	NOUN	NN	Number=Sing	_	_	_	_
9	activity	activity	NOUN	NN	Number=Sing	_	_	_	_
10	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
11	necessary	necessary	ADJ	JJ	Degree=Pos	_	_	_	_
12	but	but	CCONJ	CC	_	_	_	_	_
13	not	not	ADV	RB	_	_	_	_	_
14	sufficient	sufficient	ADJ	JJ	Degree=Pos	_	_	_	_
15	to	to	PART	TO	_	_	_	_	_
16	promote	promote	VERB	VB	VerbForm=Inf	_	_	_	_
17	viability	viability	NOUN	NN	Number=Sing	_	_	_	_
18	and	and	CCONJ	CC	_	_	_	_	SpaceAfter=No
19	/	/	PUNCT	,	_	_	_	_	SpaceAfter=No
20	or	or	CCONJ	CC	_	_	_	_	_
21	proliferation	proliferation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
22	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2866
# text = Constitutive STAT5 activity, activated through an unknown pathway not including JAK2 or EPOR, may act in concert with the constitutive PI3-kinase/PKB/Akt pathway to protect the EPO-independent HCD57-SREI cells from apoptosis and promote limited proliferation.
1	Constitutive	Constitutive	ADJ	JJ	Degree=Pos	_	_	_	_
2	STAT5	stat5	NOUN	NN	Number=Sing	_	_	_	_
3	activity	activity	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
4	,	,	PUNCT	,	_	_	_	_	_
5	activated	activate	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
6	through	through	ADP	IN	_	_	_	_	_
7	an	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
8	unknown	unknown	ADJ	JJ	Degree=Pos	_	_	_	_
9	pathway	pathway	NOUN	NN	Number=Sing	_	_	_	_
10	not	not	ADV	RB	_	_	_	_	_
11	including	include	VERB	VBG	VerbForm=Ger	_	_	_	_
12	JAK2	JAK2	NUM	CD	NumType=Card	_	_	_	_
13	or	or	CCONJ	CC	_	_	_	_	_
14	EPOR	Epor	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
15	,	,	PUNCT	,	_	_	_	_	_
16	may	may	AUX	MD	VerbForm=Fin	_	_	_	_
17	act	act	VERB	VB	VerbForm=Inf	_	_	_	_
18	in	in	ADP	IN	_	_	_	_	_
19	concert	concert	NOUN	NN	Number=Sing	_	_	_	_
20	with	with	ADP	IN	_	_	_	_	_
21	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
22	constitutive	constitutive	ADJ	JJ	Degree=Pos	_	_	_	_
23	PI3-kinase	PI3-kinase	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
24	/	/	PUNCT	,	_	_	_	_	SpaceAfter=No
25	PKB	Pkb	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
26	/	/	PUNCT	,	_	_	_	_	SpaceAfter=No
27	Akt	Akt	ADJ	JJS	Degree=Sup	_	_	_	_
28	pathway	pathway	NOUN	NN	Number=Sing	_	_	_	_
29	to	to	PART	TO	_	_	_	_	_
30	protect	protect	VERB	VB	VerbForm=Inf	_	_	_	_
31	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
32	EPO	Epo	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
33	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
34	independent	independent	ADJ	JJ	Degree=Pos	_	_	_	_
35	HCD57-SREI	Hcd57-srei	ADJ	JJ	Degree=Pos	_	_	_	_
36	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
37	from	from	ADP	IN	_	_	_	_	_
38	apoptosis	apoptosis	NOUN	NN	Number=Sing	_	_	_	_
39	and	and	CCONJ	CC	_	_	_	_	_
40	promote	promote	VERB	VB	VerbForm=Inf	_	_	_	_
41	limited	limited	ADJ	JJ	Degree=Pos	_	_	_	_
42	proliferation	proliferation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
43	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 2867
# text = Document 003003337 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	003003337	003003337	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 2868
# text = Clonality of isolated eosinophils in the hypereosinophilic syndrome.
1	Clonality	Clonality	NOUN	NN	Number=Sing	_	_	_	_
2	of	of	ADP	IN	_	_	_	_	_
3	isolated	isolate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
4	eosinophils	eosinophil	NOUN	NNS	Number=Plur	_	_	_	_
5	in	in	ADP	IN	_	_	_	_	_
6	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
7	hypereosinophilic	hypereosinophilic	ADJ	JJ	Degree=Pos	_	_	_	_
8	syndrome	syndrome	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
9	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 2869
# text = The idiopathic hypereosinophilic syndrome (IHES) is a rare disorder characterized by unexplained, persistent eosinophilia associated with multiple organ dysfunction due to eosinophilic tissue infiltration.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	idiopathic	idiopathic	ADJ	JJ	Degree=Pos	_	_	_	_
3	hypereosinophilic	hypereosinophilic	ADJ	JJ	Degree=Pos	_	_	_	_
4	syndrome	syndrome	NOUN	NN	Number=Sing	_	_	_	_
5	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
6	IHES	IHES	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
7	)	)	PUNCT	-RRB-	_	_	_	_	_
8	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
9	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
10	rare	rare	ADJ	JJ	Degree=Pos	_	_	_	_
11	disorder	disorder	NOUN	NN	Number=Sing	_	_	_	_
12	characterized	characterize	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
13	by	by	ADP	IN	_	_	_	_	_
14	unexplained	unexplain	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
15	,	,	PUNCT	,	_	_	_	_	_
16	persistent	persistent	ADJ	JJ	Degree=Pos	_	_	_	_
17	eosinophilia	eosinophilia	NOUN	NN	Number=Sing	_	_	_	_
18	associated	associate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
19	with	with	ADP	IN	_	_	_	_	_
20	multiple	multiple	ADJ	JJ	Degree=Pos	_	_	_	_
21	organ	organ	ADJ	JJ	Degree=Pos	_	_	_	_
22	dysfunction	dysfunction	NOUN	NN	Number=Sing	_	_	_	_
23	due	due	ADP	IN	_	_	_	_	_
24	to	to	ADP	IN	_	_	_	_	_
25	eosinophilic	eosinophilic	ADJ	JJ	Degree=Pos	_	_	_	_
26	tissue	tissue	NOUN	NN	Number=Sing	_	_	_	_
27	infiltration	infiltration	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
28	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2870
# text = In the absence of karyotypic abnormalities, there is no specific test to detect clonal eosinophilia in IHES.
1	In	in	ADP	IN	_	_	_	_	_
2	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
3	absence	absence	NOUN	NN	Number=Sing	_	_	_	_
4	of	of	ADP	IN	_	_	_	_	_
5	karyotypic	karyotypic	ADJ	JJ	Degree=Pos	_	_	_	_
6	abnormalities	abnormality	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
7	,	,	PUNCT	,	_	_	_	_	_
8	there	there	PRON	EX	_	_	_	_	_
9	is	be	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
10	no	no	DET	DT	_	_	_	_	_
11	specific	specific	ADJ	JJ	Degree=Pos	_	_	_	_
12	test	test	NOUN	NN	Number=Sing	_	_	_	_
13	to	to	PART	TO	_	_	_	_	_
14	detect	detect	VERB	VB	VerbForm=Inf	_	_	_	_
15	clonal	clonal	ADJ	JJ	Degree=Pos	_	_	_	_
16	eosinophilia	eosinophilion	NOUN	NN	Number=Sing	_	_	_	_
17	in	in	ADP	IN	_	_	_	_	_
18	IHES	IHES	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
19	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2871
# text = Analysis of X-chromosome inactivation patterns can be used to determine whether proliferative disorders are clonal in origin.
1	Analysis	analysis	NOUN	NN	Number=Sing	_	_	_	_
2	of	of	ADP	IN	_	_	_	_	_
3	X	X	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
4	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
5	chromosome	chromosome	ADJ	JJ	Degree=Pos	_	_	_	_
6	inactivation	inactivation	NOUN	NN	Number=Sing	_	_	_	_
7	patterns	pattern	NOUN	NNS	Number=Plur	_	_	_	_
8	can	can	AUX	MD	VerbForm=Fin	_	_	_	_
9	be	be	AUX	VB	VerbForm=Inf	_	_	_	_
10	used	use	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
11	to	to	PART	TO	_	_	_	_	_
12	determine	determine	VERB	VB	VerbForm=Inf	_	_	_	_
13	whether	whether	SCONJ	IN	_	_	_	_	_
14	proliferative	proliferative	ADJ	JJ	Degree=Pos	_	_	_	_
15	disorders	disorder	NOUN	NNS	Number=Plur	_	_	_	_
16	are	be	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
17	clonal	clonal	ADJ	JJ	Degree=Pos	_	_	_	_
18	in	in	ADP	IN	_	_	_	_	_
19	origin	origin	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
20	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2872
# text = Methylation of HpaII and Hha I sites near the polymorphic trinucleotide repeat of the human androgen receptor gene (HUMARA) has been shown to correlate with X-inactivation.
1	Methylation	Methylation	NOUN	NN	Number=Sing	_	_	_	_
2	of	of	ADP	IN	_	_	_	_	_
3	HpaII	HpaII	PROPN	NNP	Number=Sing	_	_	_	_
4	and	and	CCONJ	CC	_	_	_	_	_
5	Hha	Hha	PROPN	NNP	Number=Sing	_	_	_	_
6	I	I	PRON	PRP	Case=Nom|Number=Sing|Person=1|PronType=Prs	_	_	_	_
7	sites	site	NOUN	NNS	Number=Plur	_	_	_	_
8	near	near	ADP	IN	_	_	_	_	_
9	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
10	polymorphic	polymorphic	ADJ	JJ	Degree=Pos	_	_	_	_
11	trinucleotide	trinucleotide	NOUN	NN	Number=Sing	_	_	_	_
12	repeat	repeat	NOUN	NN	Number=Sing	_	_	_	_
13	of	of	ADP	IN	_	_	_	_	_
14	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
15	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
16	androgen	androgen	NOUN	NN	Number=Sing	_	_	_	_
17	receptor	receptor	NOUN	NN	Number=Sing	_	_	_	_
18	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
19	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
20	HUMARA	HUMARA	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
21	)	)	PUNCT	-RRB-	_	_	_	_	_
22	has	have	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
23	been	be	AUX	VBN	Tense=Past|VerbForm=Part	_	_	_	_
24	shown	show	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
25	to	to	PART	TO	_	_	_	_	_
26	correlate	correlate	VERB	VB	VerbForm=Inf	_	_	_	_
27	with	with	ADP	IN	_	_	_	_	_
28	X	x	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
29	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
30	inactivation	inactivation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
31	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2873
# text = In this study, we have used the polymerase chain reaction (PCR) with nested primers to analyze X-inactivation patterns of the HUMARA loci in purified eosinophils from female patients with eosinophilia.
1	In	in	ADP	IN	_	_	_	_	_
2	this	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
3	study	study	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
4	,	,	PUNCT	,	_	_	_	_	_
5	we	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
6	have	have	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
7	used	use	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
8	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
9	polymerase	polymerase	NOUN	NN	Number=Sing	_	_	_	_
10	chain	chain	NOUN	NN	Number=Sing	_	_	_	_
11	reaction	reaction	NOUN	NN	Number=Sing	_	_	_	_
12	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
13	PCR	PCR	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
14	)	)	PUNCT	-RRB-	_	_	_	_	_
15	with	with	ADP	IN	_	_	_	_	_
16	nested	nest	ADJ	JJ	Degree=Pos	_	_	_	_
17	primers	primer	NOUN	NNS	Number=Plur	_	_	_	_
18	to	to	PART	TO	_	_	_	_	_
19	analyze	analyze	VERB	VB	VerbForm=Inf	_	_	_	_
20	X	x	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
21	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
22	inactivation	inactivation	NOUN	NN	Number=Sing	_	_	_	_
23	patterns	pattern	NOUN	NNS	Number=Plur	_	_	_	_
24	of	of	ADP	IN	_	_	_	_	_
25	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
26	HUMARA	HUMARA	PROPN	NNP	Number=Sing	_	_	_	_
27	loci	loci	NOUN	NN	Number=Sing	_	_	_	_
28	in	in	ADP	IN	_	_	_	_	_
29	purified	purified	ADJ	JJ	Degree=Pos	_	_	_	_
30	eosinophils	eosinophil	NOUN	NNS	Number=Plur	_	_	_	_
31	from	from	ADP	IN	_	_	_	_	_
32	female	female	ADJ	JJ	Degree=Pos	_	_	_	_
33	patients	patient	NOUN	NNS	Number=Plur	_	_	_	_
34	with	with	ADP	IN	_	_	_	_	_
35	eosinophilia	eosinophilia	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
36	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2874
# text = Peripheral blood eosinophils were isolated by their autofluoresence using flow cytometric sorting.
1	Peripheral	Peripheral	ADJ	JJ	Degree=Pos	_	_	_	_
2	blood	blood	NOUN	NN	Number=Sing	_	_	_	_
3	eosinophils	eosinophil	NOUN	NNS	Number=Plur	_	_	_	_
4	were	be	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
5	isolated	isolate	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
6	by	by	ADP	IN	_	_	_	_	_
7	their	they	PRON	PRP$	Number=Plur|Person=3|Poss=Yes|PronType=Prs	_	_	_	_
8	autofluoresence	autofluoresence	NOUN	NN	Number=Sing	_	_	_	_
9	using	use	VERB	VBG	VerbForm=Ger	_	_	_	_
10	flow	flow	NOUN	NN	Number=Sing	_	_	_	_
11	cytometric	cytometric	NOUN	NN	Number=Sing	_	_	_	_
12	sorting	sorting	VERB	VBG	VerbForm=Ger	_	_	_	SpaceAfter=No
13	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2875
# text = Eosinophils purified from a female patient presenting with IHES were found to show a clonal pattern of X-inactivation.
1	Eosinophils	Eosinophils	NOUN	NNS	Number=Plur	_	_	_	_
2	purified	purify	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
3	from	from	ADP	IN	_	_	_	_	_
4	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
5	female	female	ADJ	JJ	Degree=Pos	_	_	_	_
6	patient	patient	NOUN	NN	Number=Sing	_	_	_	_
7	presenting	present	VERB	VBG	VerbForm=Ger	_	_	_	_
8	with	with	ADP	IN	_	_	_	_	_
9	IHES	IHES	PROPN	NNP	Number=Sing	_	_	_	_
10	were	be	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
11	found	find	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
12	to	to	PART	TO	_	_	_	_	_
13	show	show	VERB	VB	VerbForm=Inf	_	_	_	_
14	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
15	clonal	clonal	ADJ	JJ	Degree=Pos	_	_	_	_
16	pattern	pattern	NOUN	NN	Number=Sing	_	_	_	_
17	of	of	ADP	IN	_	_	_	_	_
18	X	x	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
19	-inactivation	-inactivation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
20	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2876
# text = Eosinophil-depleted leukocytes from this patient were polyclonal by HUMARA analysis, thus excluding skewedness of random X-inactivation.
1	Eosinophil	Eosinophil	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
2	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
3	depleted	deplet	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
4	leukocytes	leukocyte	NOUN	NNS	Number=Plur	_	_	_	_
5	from	from	ADP	IN	_	_	_	_	_
6	this	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
7	patient	patient	NOUN	NN	Number=Sing	_	_	_	_
8	were	be	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
9	polyclonal	polyclonal	ADJ	JJ	Degree=Pos	_	_	_	_
10	by	by	ADP	IN	_	_	_	_	_
11	HUMARA	HUMARA	PROPN	NNP	Number=Sing	_	_	_	_
12	analysis	analysis	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
13	,	,	PUNCT	,	_	_	_	_	_
14	thus	thus	ADV	RB	_	_	_	_	_
15	excluding	exclude	VERB	VBG	VerbForm=Ger	_	_	_	_
16	skewedness	skewedness	NOUN	NN	Number=Sing	_	_	_	_
17	of	of	ADP	IN	_	_	_	_	_
18	random	random	NOUN	NN	Number=Sing	_	_	_	_
19	X	x	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
20	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
21	inactivation	inactivation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
22	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2877
# text = After corticosteroid suppression of her blood eosinophilia, a clonal population of eosinophils could no longer be detected in purified eosinophils.
1	After	after	ADP	IN	_	_	_	_	_
2	corticosteroid	corticosteroid	ADJ	JJ	Degree=Pos	_	_	_	_
3	suppression	suppression	NOUN	NN	Number=Sing	_	_	_	_
4	of	of	ADP	IN	_	_	_	_	_
5	her	she	PRON	PRP$	Gender=Fem|Number=Sing|Person=3|Poss=Yes|PronType=Prs	_	_	_	_
6	blood	blood	NOUN	NN	Number=Sing	_	_	_	_
7	eosinophilia	eosinophilia	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
8	,	,	PUNCT	,	_	_	_	_	_
9	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
10	clonal	clonal	ADJ	JJ	Degree=Pos	_	_	_	_
11	population	population	NOUN	NN	Number=Sing	_	_	_	_
12	of	of	ADP	IN	_	_	_	_	_
13	eosinophils	eosinophil	NOUN	NNS	Number=Plur	_	_	_	_
14	could	could	AUX	MD	VerbForm=Fin	_	_	_	_
15	no	no	ADV	RB	_	_	_	_	_
16	longer	longer	ADV	RBR	Degree=Cmp	_	_	_	_
17	be	be	AUX	VB	VerbForm=Inf	_	_	_	_
18	detected	detect	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
19	in	in	ADP	IN	_	_	_	_	_
20	purified	purify	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
21	eosinophils	eosinophil	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
22	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2878
# text = In contrast, eosinophils purified from a patient with Churg-Strauss syndrome and from six patients with reactive eosinophilias attributed to allergy, parasitic infection, or drug reaction showed a polyclonal pattern of X-inactivation by HUMARA analysis.
1	In	in	ADP	IN	_	_	_	_	_
2	contrast	contrast	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
3	,	,	PUNCT	,	_	_	_	_	_
4	eosinophils	eosinophil	NOUN	NNS	Number=Plur	_	_	_	_
5	purified	purify	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
6	from	from	ADP	IN	_	_	_	_	_
7	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
8	patient	patient	NOUN	NN	Number=Sing	_	_	_	_
9	with	with	ADP	IN	_	_	_	_	_
10	Churg	Churg	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
11	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
12	Strauss	Strauss	PROPN	NNP	Number=Sing	_	_	_	_
13	syndrome	syndrome	NOUN	NN	Number=Sing	_	_	_	_
14	and	and	CCONJ	CC	_	_	_	_	_
15	from	from	ADP	IN	_	_	_	_	_
16	six	six	NUM	CD	NumType=Card	_	_	_	_
17	patients	patient	NOUN	NNS	Number=Plur	_	_	_	_
18	with	with	ADP	IN	_	_	_	_	_
19	reactive	reactive	ADJ	JJ	Degree=Pos	_	_	_	_
20	eosinophilias	eosinophilia	NOUN	NNS	Number=Plur	_	_	_	_
21	attributed	attribute	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
22	to	to	ADP	IN	_	_	_	_	_
23	allergy	allergy	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
24	,	,	PUNCT	,	_	_	_	_	_
25	parasitic	parasitic	ADJ	JJ	Degree=Pos	_	_	_	_
26	infection	infection	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
27	,	,	PUNCT	,	_	_	_	_	_
28	or	or	CCONJ	CC	_	_	_	_	_
29	drug	drug	NOUN	NN	Number=Sing	_	_	_	_
30	reaction	reaction	NOUN	NN	Number=Sing	_	_	_	_
31	showed	show	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
32	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
33	polyclonal	polyclonal	ADJ	JJ	Degree=Pos	_	_	_	_
34	pattern	pattern	NOUN	NN	Number=Sing	_	_	_	_
35	of	of	ADP	IN	_	_	_	_	_
36	X	x	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
37	-inactivation	-inactivation	NOUN	NN	Number=Sing	_	_	_	_
38	by	by	ADP	IN	_	_	_	_	_
39	HUMARA	HUMARA	PROPN	NNP	Number=Sing	_	_	_	_
40	analysis	analysis	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
41	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2879
# text = The finding of clonal eosinophilia in a patient presenting with IHES indicates that such patients may have, in reality, a low-grade clonal disorder that can be distinguished from reactive eosinophilias by HUMARA analysis.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	finding	finding	NOUN	NN	Number=Sing	_	_	_	_
3	of	of	ADP	IN	_	_	_	_	_
4	clonal	clonal	ADJ	JJ	Degree=Pos	_	_	_	_
5	eosinophilia	eosinophilia	NOUN	NN	Number=Sing	_	_	_	_
6	in	in	ADP	IN	_	_	_	_	_
7	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
8	patient	patient	NOUN	NN	Number=Sing	_	_	_	_
9	presenting	present	VERB	VBG	VerbForm=Ger	_	_	_	_
10	with	with	ADP	IN	_	_	_	_	_
11	IHES	IHES	PROPN	NNP	Number=Sing	_	_	_	_
12	indicates	indicate	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
13	that	that	SCONJ	IN	_	_	_	_	_
14	such	such	ADJ	JJ	Degree=Pos	_	_	_	_
15	patients	patient	NOUN	NNS	Number=Plur	_	_	_	_
16	may	may	AUX	MD	VerbForm=Fin	_	_	_	_
17	have	have	VERB	VB	VerbForm=Inf	_	_	_	SpaceAfter=No
18	,	,	PUNCT	,	_	_	_	_	_
19	in	in	ADP	IN	_	_	_	_	_
20	reality	reality	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
21	,	,	PUNCT	,	_	_	_	_	_
22	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
23	low	low	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
24	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
25	grade	grade	NOUN	NN	Number=Sing	_	_	_	_
26	clonal	clonal	ADJ	JJ	Degree=Pos	_	_	_	_
27	disorder	disorder	NOUN	NN	Number=Sing	_	_	_	_
28	that	that	PRON	WDT	PronType=Rel	_	_	_	_
29	can	can	AUX	MD	VerbForm=Fin	_	_	_	_
30	be	be	AUX	VB	VerbForm=Inf	_	_	_	_
31	distinguished	distinguish	ADJ	JJ	Degree=Pos	_	_	_	_
32	from	from	ADP	IN	_	_	_	_	_
33	reactive	reactive	ADJ	JJ	Degree=Pos	_	_	_	_
34	eosinophilias	eosinophilia	NOUN	NNS	Number=Plur	_	_	_	_
35	by	by	ADP	IN	_	_	_	_	_
36	HUMARA	HUMARA	ADJ	JJ	Degree=Pos	_	_	_	_
37	analysis	analysis	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
38	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2880
# text = Further, the method described can be used to monitor disease progression.
1	Further	further	ADV	RB	_	_	_	_	SpaceAfter=No
2	,	,	PUNCT	,	_	_	_	_	_
3	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
4	method	method	NOUN	NN	Number=Sing	_	_	_	_
5	described	describe	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
6	can	can	AUX	MD	VerbForm=Fin	_	_	_	_
7	be	be	AUX	VB	VerbForm=Inf	_	_	_	_
8	used	use	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
9	to	to	PART	TO	_	_	_	_	_
10	monitor	monitor	VERB	VB	VerbForm=Inf	_	_	_	_
11	disease	disease	NOUN	NN	Number=Sing	_	_	_	_
12	progression	progression	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
13	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 2881
# text = Document 003003338 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	003003338	003003338	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 2882
# text = Mice deficient for the 55 kd tumor necrosis factor receptor are resistant to endotoxic shock, yet succumb to L. monocytogenes infection.
1	Mice	mice	NOUN	NN	Number=Sing	_	_	_	_
2	deficient	deficient	NOUN	NN	Number=Sing	_	_	_	_
3	for	for	ADP	IN	_	_	_	_	_
4	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
5	55	55	NUM	CD	NumType=Card	_	_	_	_
6	kd	kd	NOUN	NN	Number=Sing	_	_	_	_
7	tumor	tumor	NOUN	NN	Number=Sing	_	_	_	_
8	necrosis	necrosis	NOUN	NN	Number=Sing	_	_	_	_
9	factor	factor	NOUN	NN	Number=Sing	_	_	_	_
10	receptor	receptor	NOUN	NN	Number=Sing	_	_	_	_
11	are	be	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
12	resistant	resistant	ADJ	JJ	Degree=Pos	_	_	_	_
13	to	to	ADP	IN	_	_	_	_	_
14	endotoxic	endotoxic	ADJ	JJ	Degree=Pos	_	_	_	_
15	shock	shock	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
16	,	,	PUNCT	,	_	_	_	_	_
17	yet	yet	CCONJ	CC	_	_	_	_	_
18	succumb	succumb	VERB	VB	Mood=Imp|VerbForm=Fin	_	_	_	_
19	to	to	ADP	IN	_	_	_	_	_
20	L.	L.	PROPN	NNP	Number=Sing	_	_	_	_
21	monocytogenes	monocytogene	NOUN	NNS	Number=Plur	_	_	_	_
22	infection	infection	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
23	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 2883
# text = The multiple biological activities of tumor necrosis factor (TNF) are mediated by two distinct cell surface receptors of 55 kd (TNFRp55) and 75 kd (TNFRp75).
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	multiple	multiple	ADJ	JJ	Degree=Pos	_	_	_	_
3	biological	biological	ADJ	JJ	Degree=Pos	_	_	_	_
4	activities	activity	NOUN	NNS	Number=Plur	_	_	_	_
5	of	of	ADP	IN	_	_	_	_	_
6	tumor	tumor	NOUN	NN	Number=Sing	_	_	_	_
7	necrosis	necrosis	NOUN	NN	Number=Sing	_	_	_	_
8	factor	factor	NOUN	NN	Number=Sing	_	_	_	_
9	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
10	TNF	TNF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
11	)	)	PUNCT	-RRB-	_	_	_	_	_
12	are	be	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
13	mediated	mediate	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
14	by	by	ADP	IN	_	_	_	_	_
15	two	two	NUM	CD	NumType=Card	_	_	_	_
16	distinct	distinct	ADJ	JJ	Degree=Pos	_	_	_	_
17	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
18	surface	surface	NOUN	NN	Number=Sing	_	_	_	_
19	receptors	receptor	NOUN	NNS	Number=Plur	_	_	_	_
20	of	of	ADP	IN	_	_	_	_	_
21	55	55	NUM	CD	NumType=Card	_	_	_	_
22	kd	k	NOUN	NN	Number=Sing	_	_	_	_
23	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
24	TNFRp55	TNFRp55	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
25	)	)	PUNCT	-RRB-	_	_	_	_	_
26	and	and	CCONJ	CC	_	_	_	_	_
27	75	75	NUM	CD	NumType=Card	_	_	_	_
28	kd	kd	NOUN	NN	Number=Sing	_	_	_	_
29	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
30	TNFRp75	Tnfrp75	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
31	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
32	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2884
# text = Using gene targeting, we generated a TNFRp55-deficient mouse strain.
1	Using	use	VERB	VBG	VerbForm=Ger	_	_	_	_
2	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
3	targeting	targeting	VERB	VBG	VerbForm=Ger	_	_	_	SpaceAfter=No
4	,	,	PUNCT	,	_	_	_	_	_
5	we	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
6	generated	generate	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
7	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
8	TNFRp55	TNFRp55	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
9	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
10	deficient	deficient	NOUN	NN	Number=Sing	_	_	_	_
11	mouse	mouse	NOUN	NN	Number=Sing	_	_	_	_
12	strain	strain	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
13	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2885
# text = Cells from TNFRp55-/-mutant mice lack expression of TNFRp55 but display normal numbers of high affinity TNFRp75 molecules.
1	Cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
2	from	from	ADP	IN	_	_	_	_	_
3	TNFRp55	TNFRp55	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
4	-/-	-/-	PUNCT	.	_	_	_	_	SpaceAfter=No
5	mutant	mutant	ADJ	JJ	Degree=Pos	_	_	_	_
6	mice	mouse	NOUN	NN	Number=Sing	_	_	_	_
7	lack	lack	NOUN	NN	Number=Sing	_	_	_	_
8	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
9	of	of	ADP	IN	_	_	_	_	_
10	TNFRp55	TNFRp55	NUM	CD	NumType=Card	_	_	_	_
11	but	but	CCONJ	CC	_	_	_	_	_
12	display	display	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
13	normal	normal	ADJ	JJ	Degree=Pos	_	_	_	_
14	numbers	number	NOUN	NNS	Number=Plur	_	_	_	_
15	of	of	ADP	IN	_	_	_	_	_
16	high	high	ADJ	JJ	Degree=Pos	_	_	_	_
17	affinity	affinity	NOUN	NN	Number=Sing	_	_	_	_
18	TNFRp75	TNFRp75	NUM	CD	NumType=Card	_	_	_	_
19	molecules	molecule	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
20	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2886
# text = Thymocyte development and lymphocyte populations are unaltered, and clonal deletion of potentially self-reactive T cells is not impaired.
1	Thymocyte	Thymocyte	NOUN	NN	Number=Sing	_	_	_	_
2	development	development	NOUN	NN	Number=Sing	_	_	_	_
3	and	and	CCONJ	CC	_	_	_	_	_
4	lymphocyte	lymphocyte	NOUN	NN	Number=Sing	_	_	_	_
5	populations	population	NOUN	NNS	Number=Plur	_	_	_	_
6	are	be	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
7	unaltered	unalter	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
8	,	,	PUNCT	,	_	_	_	_	_
9	and	and	CCONJ	CC	_	_	_	_	_
10	clonal	clonal	ADJ	JJ	Degree=Pos	_	_	_	_
11	deletion	deletion	NOUN	NN	Number=Sing	_	_	_	_
12	of	of	ADP	IN	_	_	_	_	_
13	potentially	potentially	ADV	RB	_	_	_	_	_
14	self	self	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
15	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
16	reactive	reactive	ADJ	JJ	Degree=Pos	_	_	_	_
17	T	t	PROPN	NNP	Number=Sing	_	_	_	_
18	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
19	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
20	not	not	PART	RB	_	_	_	_	_
21	impaired	impaire	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
22	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2887
# text = However, TNF signaling is largely abolished, as judged by the failure of TNF to induce NF-kappa B in T lymphocytes from TNFRp55-deficient mice.
1	However	however	ADV	RB	_	_	_	_	SpaceAfter=No
2	,	,	PUNCT	,	_	_	_	_	_
3	TNF	TNF	SCONJ	IN	_	_	_	_	_
4	signaling	signaling	NOUN	NN	Number=Sing	_	_	_	_
5	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
6	largely	largely	ADV	RB	_	_	_	_	_
7	abolished	abolish	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	SpaceAfter=No
8	,	,	PUNCT	,	_	_	_	_	_
9	as	as	SCONJ	IN	_	_	_	_	_
10	judged	judge	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
11	by	by	ADP	IN	_	_	_	_	_
12	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
13	failure	failure	NOUN	NN	Number=Sing	_	_	_	_
14	of	of	ADP	IN	_	_	_	_	_
15	TNF	TNF	PROPN	NNP	Number=Sing	_	_	_	_
16	to	to	PART	TO	_	_	_	_	_
17	induce	induce	VERB	VB	VerbForm=Inf	_	_	_	_
18	NF	Nf	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
19	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
20	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_
21	B	b	NOUN	NN	Number=Sing	_	_	_	_
22	in	in	ADP	IN	_	_	_	_	_
23	T	t	PROPN	NNP	Number=Sing	_	_	_	_
24	lymphocytes	lymphocyte	NOUN	NNS	Number=Plur	_	_	_	_
25	from	from	ADP	IN	_	_	_	_	_
26	TNFRp55	TNFRp55	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
27	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
28	deficient	deficient	ADJ	JJ	Degree=Pos	_	_	_	_
29	mice	mouse	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
30	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2888
# text = The loss of TNFRp55 function renders mice resistant to lethal dosages of either lipopolysaccharides or S. aureus enterotoxin B.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	loss	loss	NOUN	NN	Number=Sing	_	_	_	_
3	of	of	ADP	IN	_	_	_	_	_
4	TNFRp55	TNFRp55	NUM	CD	NumType=Card	_	_	_	_
5	function	function	NOUN	NN	Number=Sing	_	_	_	_
6	renders	render	NOUN	NNS	Number=Plur	_	_	_	_
7	mice	mouse	NOUN	NNS	Number=Plur	_	_	_	_
8	resistant	resistant	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
9	to	to	ADP	IN	_	_	_	_	_
10	lethal	lethal	ADJ	JJ	Degree=Pos	_	_	_	_
11	dosages	dosage	NOUN	NNS	Number=Plur	_	_	_	_
12	of	of	ADP	IN	_	_	_	_	_
13	either	either	CCONJ	CC	_	_	_	_	_
14	lipopolysaccharides	lipopolysaccharide	NOUN	NNS	Number=Plur	_	_	_	_
15	or	or	CCONJ	CC	_	_	_	_	_
16	S.	S.	PROPN	NNP	Number=Sing	_	_	_	_
17	aureus	aureus	ADV	RB	_	_	_	_	_
18	enterotoxin	enterotoxin	ADP	IN	_	_	_	_	_
19	B	b	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
20	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2889
# text = In contrast, TNFRp55-deficient mice are severely impaired to clear L. monocytogenes and readily succumb to infection.
1	In	in	ADP	IN	_	_	_	_	_
2	contrast	contrast	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
3	,	,	PUNCT	,	_	_	_	_	_
4	TNFRp55	TNFRp55	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
5	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
6	deficient	deficient	NOUN	NN	Number=Sing	_	_	_	_
7	mice	mouse	NOUN	NNS	Number=Plur	_	_	_	_
8	are	be	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
9	severely	severely	ADV	RB	_	_	_	_	_
10	impaired	impaire	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
11	to	to	ADP	IN	_	_	_	_	_
12	clear	clear	ADJ	JJ	Degree=Pos	_	_	_	_
13	L.	L.	PROPN	NNP	Number=Sing	_	_	_	_
14	monocytogenes	monocytogene	NOUN	NNS	Number=Plur	_	_	_	_
15	and	and	CCONJ	CC	_	_	_	_	_
16	readily	readily	ADV	RB	_	_	_	_	_
17	succumb	succumb	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
18	to	to	ADP	IN	_	_	_	_	_
19	infection	infection	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
20	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2890
# text = Thus, the 55 kd TNFR plays a decisive role in the host's defense against microorganisms and their pathogenic factors.
1	Thus	thus	ADV	RB	_	_	_	_	SpaceAfter=No
2	,	,	PUNCT	,	_	_	_	_	_
3	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
4	55	55	NUM	CD	NumType=Card	_	_	_	_
5	kd	kd	NOUN	NN	Number=Sing	_	_	_	_
6	TNFR	Tnfr	PROPN	NNP	Number=Sing	_	_	_	_
7	plays	play	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
8	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
9	decisive	decisive	ADJ	JJ	Degree=Pos	_	_	_	_
10	role	role	NOUN	NN	Number=Sing	_	_	_	_
11	in	in	ADP	IN	_	_	_	_	_
12	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
13	host	host	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
14	's	's	PART	POS	_	_	_	_	_
15	defense	defense	NOUN	NN	Number=Sing	_	_	_	_
16	against	against	ADP	IN	_	_	_	_	_
17	microorganisms	microorganism	NOUN	NNS	Number=Plur	_	_	_	_
18	and	and	CCONJ	CC	_	_	_	_	_
19	their	they	PRON	PRP$	Number=Plur|Person=3|Poss=Yes|PronType=Prs	_	_	_	_
20	pathogenic	pathogenic	ADJ	JJ	Degree=Pos	_	_	_	_
21	factors	factor	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
22	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 2891
# text = Document 003003339 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	003003339	003003339	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 2892
# text = T helper differentiation proceeds through Stat1-dependent, Stat4-dependent and Stat4-independent phases.
1	T	t	PROPN	NNP	Number=Sing	_	_	_	_
2	helper	helper	ADJ	JJR	Degree=Cmp	_	_	_	_
3	differentiation	differentiation	NOUN	NN	Number=Sing	_	_	_	_
4	proceeds	proceed	NOUN	NNS	Number=Plur	_	_	_	_
5	through	through	ADP	IN	_	_	_	_	_
6	Stat1	Stat1	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
7	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
8	dependent	dependent	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
9	,	,	PUNCT	,	_	_	_	_	_
10	Stat4	Stat4	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
11	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
12	dependent	dependent	ADJ	JJ	Degree=Pos	_	_	_	_
13	and	and	CCONJ	CC	_	_	_	_	_
14	Stat4	Stat4	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
15	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
16	independent	independent	ADJ	JJ	Degree=Pos	_	_	_	_
17	phases	phase	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
18	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 2893
# text = Much of our focus in understanding Th1/Th2 development has been on the signals delivered by IL-12 and IL-4 as final determinants of terminal T cell differentiation.
1	Much	much	ADJ	JJ	Degree=Pos	_	_	_	_
2	of	of	ADP	IN	_	_	_	_	_
3	our	we	PRON	PRP$	Number=Plur|Person=1|Poss=Yes|PronType=Prs	_	_	_	_
4	focus	focus	NOUN	NN	Number=Sing	_	_	_	_
5	in	in	ADP	IN	_	_	_	_	_
6	understanding	understanding	NOUN	NN	Number=Sing	_	_	_	_
7	Th1	th1	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
8	/	/	PUNCT	,	_	_	_	_	SpaceAfter=No
9	Th2	Th2	NUM	CD	NumType=Card	_	_	_	_
10	development	development	NOUN	NN	Number=Sing	_	_	_	_
11	has	have	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
12	been	be	AUX	VBN	Tense=Past|VerbForm=Part	_	_	_	_
13	on	on	ADP	IN	_	_	_	_	_
14	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
15	signals	signal	NOUN	NNS	Number=Plur	_	_	_	_
16	delivered	deliver	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
17	by	by	ADP	IN	_	_	_	_	_
18	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
19	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
20	12	12	NUM	CD	NumType=Card	_	_	_	_
21	and	and	CCONJ	CC	_	_	_	_	_
22	IL	Il	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
23	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
24	4	4	NUM	CD	NumType=Card	_	_	_	_
25	as	as	ADP	IN	_	_	_	_	_
26	final	final	ADJ	JJ	Degree=Pos	_	_	_	_
27	determinants	determinant	NOUN	NNS	Number=Plur	_	_	_	_
28	of	of	ADP	IN	_	_	_	_	_
29	terminal	terminal	ADJ	JJ	Degree=Pos	_	_	_	_
30	T	T	PROPN	NNP	Number=Sing	_	_	_	_
31	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
32	differentiation	differentiation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
33	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2894
# text = Because extinction of IL-12 signaling in early Th2 development could potentially be important in imprinting a more permanent Th2 phenotype on a population of T cells, we have also examined various parameters regulating the IL-12 signaling pathway.
1	Because	because	SCONJ	IN	_	_	_	_	_
2	extinction	extinction	NOUN	NN	Number=Sing	_	_	_	_
3	of	of	ADP	IN	_	_	_	_	_
4	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
5	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
6	12	12	NUM	CD	NumType=Card	_	_	_	_
7	signaling	signaling	NOUN	NN	Number=Sing	_	_	_	_
8	in	in	ADP	IN	_	_	_	_	_
9	early	early	ADJ	JJ	Degree=Pos	_	_	_	_
10	Th2	Th2	NUM	CD	NumType=Card	_	_	_	_
11	development	development	NOUN	NN	Number=Sing	_	_	_	_
12	could	could	AUX	MD	VerbForm=Fin	_	_	_	_
13	potentially	potentially	ADV	RB	_	_	_	_	_
14	be	be	AUX	VB	VerbForm=Inf	_	_	_	_
15	important	important	ADJ	JJ	Degree=Pos	_	_	_	_
16	in	in	SCONJ	IN	_	_	_	_	_
17	imprinting	imprint	VERB	VBG	VerbForm=Ger	_	_	_	_
18	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
19	more	more	ADV	RBR	_	_	_	_	_
20	permanent	permanent	ADJ	JJ	Degree=Pos	_	_	_	_
21	Th2	Th2	NUM	CD	NumType=Card	_	_	_	_
22	phenotype	phenotype	NOUN	NN	Number=Sing	_	_	_	_
23	on	on	ADP	IN	_	_	_	_	_
24	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
25	population	population	NOUN	NN	Number=Sing	_	_	_	_
26	of	of	ADP	IN	_	_	_	_	_
27	T	t	PROPN	NNP	Number=Sing	_	_	_	_
28	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
29	,	,	PUNCT	,	_	_	_	_	_
30	we	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
31	have	have	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
32	also	also	ADV	RB	_	_	_	_	_
33	examined	examine	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
34	various	various	ADJ	JJ	Degree=Pos	_	_	_	_
35	parameters	parameter	NOUN	NNS	Number=Plur	_	_	_	_
36	regulating	regulate	VERB	VBG	VerbForm=Ger	_	_	_	_
37	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
38	IL	Il	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
39	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
40	12	12	NUM	CD	NumType=Card	_	_	_	_
41	signaling	signaling	NOUN	NN	Number=Sing	_	_	_	_
42	pathway	pathway	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
43	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2895
# text = Whereas IL-4 appears to repress functional IL-12 signaling through inhibition of IL-12R beta 2 expression, IFN-gamma in the mouse, and IFN-alpha in the human appear to induce IL-12R beta 2 expression and promote IL-12 responsiveness.
1	Whereas	whereas	PROPN	NNP	Number=Sing	_	_	_	_
2	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
3	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
4	4	4	NUM	CD	NumType=Card	_	_	_	_
5	appears	appear	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
6	to	to	PART	TO	_	_	_	_	_
7	repress	repress	VERB	VB	VerbForm=Inf	_	_	_	_
8	functional	functional	ADJ	JJ	Degree=Pos	_	_	_	_
9	IL	Il	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
10	-	-	SYM	SYM	_	_	_	_	SpaceAfter=No
11	12	12	NUM	CD	NumType=Card	_	_	_	_
12	signaling	signaling	VERB	VBG	VerbForm=Ger	_	_	_	_
13	through	through	ADP	IN	_	_	_	_	_
14	inhibition	inhibition	NOUN	NN	Number=Sing	_	_	_	_
15	of	of	ADP	IN	_	_	_	_	_
16	IL-	IL-	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
17	12R	12R	NOUN	NN	Number=Sing	_	_	_	_
18	beta	beta	NOUN	NN	Number=Sing	_	_	_	_
19	2	2	NUM	CD	NumType=Card	_	_	_	_
20	expression	expression	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
21	,	,	PUNCT	,	_	_	_	_	_
22	IFN	Ifn	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
23	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
24	gamma	gamma	NOUN	NN	Number=Sing	_	_	_	_
25	in	in	ADP	IN	_	_	_	_	_
26	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
27	mouse	mouse	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
28	,	,	PUNCT	,	_	_	_	_	_
29	and	and	CCONJ	CC	_	_	_	_	_
30	IFN	Ifn	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
31	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
32	alpha	alpha	NOUN	NN	Number=Sing	_	_	_	_
33	in	in	ADP	IN	_	_	_	_	_
34	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
35	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
36	appear	appear	NOUN	NN	Number=Sing	_	_	_	_
37	to	to	PART	TO	_	_	_	_	_
38	induce	induce	VERB	VB	VerbForm=Inf	_	_	_	_
39	IL	Il	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
40	-12R	-12R	PROPN	NNP	Number=Sing	_	_	_	_
41	beta	beta	NOUN	NN	Number=Sing	_	_	_	_
42	2	2	NUM	CD	NumType=Card	_	_	_	_
43	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
44	and	and	CCONJ	CC	_	_	_	_	_
45	promote	promote	VERB	VB	VerbForm=Inf	_	_	_	_
46	IL	Il	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
47	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
48	12	12	NUM	CD	NumType=Card	_	_	_	_
49	responsiveness	responsiveness	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
50	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2896
# text = We propose that Th1 development can be considered in two stages, capacitance and development.
1	We	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
2	propose	propose	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
3	that	that	SCONJ	IN	_	_	_	_	_
4	Th1	Th1	NUM	CD	NumType=Card	_	_	_	_
5	development	development	NOUN	NN	Number=Sing	_	_	_	_
6	can	can	AUX	MD	VerbForm=Fin	_	_	_	_
7	be	be	AUX	VB	VerbForm=Inf	_	_	_	_
8	considered	consider	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
9	in	in	ADP	IN	_	_	_	_	_
10	two	two	NUM	CD	NumType=Card	_	_	_	_
11	stages	stage	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
12	,	,	PUNCT	,	_	_	_	_	_
13	capacitance	capacitance	NOUN	NN	Number=Sing	_	_	_	_
14	and	and	CCONJ	CC	_	_	_	_	_
15	development	development	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
16	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2897
# text = Capacitance would simply involve expression of IL-12R beta 1 and beta 2 subunits, regulated by TCR, IL-4 and IFNs.
1	Capacitance	Capacitance	NOUN	NN	Number=Sing	_	_	_	_
2	would	would	AUX	MD	VerbForm=Fin	_	_	_	_
3	simply	simply	ADV	RB	_	_	_	_	_
4	involve	involve	VERB	VB	VerbForm=Inf	_	_	_	_
5	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
6	of	of	ADP	IN	_	_	_	_	_
7	IL-	IL-	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
8	12R	12R	NOUN	NN	Number=Sing	_	_	_	_
9	beta	beta	NOUN	NN	Number=Sing	_	_	_	_
10	1	1	NUM	CD	NumType=Card	_	_	_	_
11	and	and	CCONJ	CC	_	_	_	_	_
12	beta	beta	NOUN	NN	Number=Sing	_	_	_	_
13	2	2	NUM	CD	NumType=Card	_	_	_	_
14	subunits	subunit	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
15	,	,	PUNCT	,	_	_	_	_	_
16	regulated	regulate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
17	by	by	ADP	IN	_	_	_	_	_
18	TCR	TCR	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
19	,	,	PUNCT	,	_	_	_	_	_
20	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
21	-	-	SYM	SYM	_	_	_	_	SpaceAfter=No
22	4	4	NUM	CD	NumType=Card	_	_	_	_
23	and	and	CCONJ	CC	_	_	_	_	_
24	IFNs	IFNs	PROPN	NNPS	Number=Plur	_	_	_	SpaceAfter=No
25	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2898
# text = The second stage, development, we propose is the true IL-12 induced developmental stage, involving expression of Stat4 inducible proteins.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	second	second	ADJ	JJ	Degree=Pos|NumType=Ord	_	_	_	_
3	stage	stage	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
4	,	,	PUNCT	,	_	_	_	_	_
5	development	development	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
6	,	,	PUNCT	,	_	_	_	_	_
7	we	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
8	propose	propose	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
9	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
10	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
11	true	true	ADJ	JJ	Degree=Pos	_	_	_	_
12	IL	Il	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
13	-	-	SYM	SYM	_	_	_	_	SpaceAfter=No
14	12	12	NUM	CD	NumType=Card	_	_	_	_
15	induced	induce	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
16	developmental	developmental	ADJ	JJ	Degree=Pos	_	_	_	_
17	stage	stage	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
18	,	,	PUNCT	,	_	_	_	_	_
19	involving	involve	VERB	VBG	VerbForm=Ger	_	_	_	_
20	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
21	of	of	ADP	IN	_	_	_	_	_
22	Stat4	Stat4	NUM	CD	NumType=Card	_	_	_	_
23	inducible	inducible	ADJ	JJ	Degree=Pos	_	_	_	_
24	proteins	protein	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
25	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2899
# text = In the human, this may also occur via IFN-alpha, which is able to activate Stat4.
1	In	in	ADP	IN	_	_	_	_	_
2	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
3	human	human	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
4	,	,	PUNCT	,	_	_	_	_	_
5	this	this	PRON	DT	Number=Sing|PronType=Dem	_	_	_	_
6	may	may	AUX	MD	VerbForm=Fin	_	_	_	_
7	also	also	ADV	RB	_	_	_	_	_
8	occur	occur	VERB	VB	VerbForm=Inf	_	_	_	_
9	via	via	ADP	IN	_	_	_	_	_
10	IFN	IFN	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
11	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
12	alpha	alpha	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
13	,	,	PUNCT	,	_	_	_	_	_
14	which	which	PRON	WDT	PronType=Rel	_	_	_	_
15	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
16	able	able	ADJ	JJ	Degree=Pos	_	_	_	_
17	to	to	PART	TO	_	_	_	_	_
18	activate	activate	VERB	VB	VerbForm=Inf	_	_	_	_
19	Stat4	Stat4	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
20	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2900
# text = It is perhaps possible that all of Stat4 actions on Th1 development may be exert directly by Stat4 at the IFN-gamma gene, however we suggest that, more likely, Stat4 may act to induce Th1 development through the induction of other non-cytokine genes, whose stable expression maintains the transcriptional state of a Th1 cell.
1	It	it	PRON	PRP	Case=Nom|Gender=Neut|Number=Sing|Person=3|PronType=Prs	_	_	_	_
2	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
3	perhaps	perhaps	ADV	RB	_	_	_	_	_
4	possible	possible	ADJ	JJ	Degree=Pos	_	_	_	_
5	that	that	SCONJ	IN	_	_	_	_	_
6	all	all	DET	DT	_	_	_	_	_
7	of	of	ADP	IN	_	_	_	_	_
8	Stat4	Stat4	NUM	CD	NumType=Card	_	_	_	_
9	actions	action	NOUN	NNS	Number=Plur	_	_	_	_
10	on	on	ADP	IN	_	_	_	_	_
11	Th1	th1	NUM	CD	NumType=Card	_	_	_	_
12	development	development	NOUN	NN	Number=Sing	_	_	_	_
13	may	may	AUX	MD	VerbForm=Fin	_	_	_	_
14	be	be	AUX	VB	VerbForm=Inf	_	_	_	_
15	exert	exert	VERB	VB	VerbForm=Inf	_	_	_	_
16	directly	directly	ADV	RB	_	_	_	_	_
17	by	by	ADP	IN	_	_	_	_	_
18	Stat4	Stat4	PROPN	NNP	Number=Sing	_	_	_	_
19	at	at	ADP	IN	_	_	_	_	_
20	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
21	IFN	Ifn	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
22	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
23	gamma	gamma	NOUN	NN	Number=Sing	_	_	_	_
24	gene	gene	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
25	,	,	PUNCT	,	_	_	_	_	_
26	however	however	ADV	RB	_	_	_	_	_
27	we	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
28	suggest	suggest	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
29	that	that	PRON	DT	Number=Sing|PronType=Dem	_	_	_	SpaceAfter=No
30	,	,	PUNCT	,	_	_	_	_	_
31	more	more	ADV	RBR	_	_	_	_	_
32	likely	likely	ADV	RB	_	_	_	_	SpaceAfter=No
33	,	,	PUNCT	,	_	_	_	_	_
34	Stat4	Stat4	PROPN	NNP	Number=Sing	_	_	_	_
35	may	may	AUX	MD	VerbForm=Fin	_	_	_	_
36	act	act	VERB	VB	VerbForm=Inf	_	_	_	_
37	to	to	PART	TO	_	_	_	_	_
38	induce	induce	VERB	VB	VerbForm=Inf	_	_	_	_
39	Th1	Th1	NUM	CD	NumType=Card	_	_	_	_
40	development	development	NOUN	NN	Number=Sing	_	_	_	_
41	through	through	ADP	IN	_	_	_	_	_
42	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
43	induction	induction	NOUN	NN	Number=Sing	_	_	_	_
44	of	of	ADP	IN	_	_	_	_	_
45	other	other	ADJ	JJ	Degree=Pos	_	_	_	_
46	non-cytokine	non-cytokine	ADJ	JJ	Degree=Pos	_	_	_	_
47	genes	gene	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
48	,	,	PUNCT	,	_	_	_	_	_
49	whose	whose	PRON	WP$	Poss=Yes|PronType=Int	_	_	_	_
50	stable	stable	ADJ	JJ	Degree=Pos	_	_	_	_
51	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
52	maintains	maintain	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
53	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
54	transcriptional	transcriptional	ADJ	JJ	Degree=Pos	_	_	_	_
55	state	state	NOUN	NN	Number=Sing	_	_	_	_
56	of	of	ADP	IN	_	_	_	_	_
57	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
58	Th1	Th1	NUM	CD	NumType=Card	_	_	_	_
59	cell	cell	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
60	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 2901
# text = Document 003003343 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	003003343	003003343	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 2902
# text = Differential inhibition of Smad6 and Smad7 on bone morphogenetic protein- and activin-mediated growth arrest and apoptosis in B cells.
1	Differential	differential	ADJ	JJ	Degree=Pos	_	_	_	_
2	inhibition	inhibition	NOUN	NN	Number=Sing	_	_	_	_
3	of	of	ADP	IN	_	_	_	_	_
4	Smad6	Smad6	NUM	CD	NumType=Card	_	_	_	_
5	and	and	CCONJ	CC	_	_	_	_	_
6	Smad7	Smad7	NUM	CD	NumType=Card	_	_	_	_
7	on	on	ADP	IN	_	_	_	_	_
8	bone	bone	PRON	NN	Number=Sing	_	_	_	_
9	morphogenetic	morphogenetic	ADJ	JJ	Degree=Pos	_	_	_	_
10	protein	protein	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
11	-	-	PUNCT	,	_	_	_	_	_
12	and	and	CCONJ	CC	_	_	_	_	_
13	activin	activin	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
14	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
15	mediated	mediate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
16	growth	growth	NOUN	NN	Number=Sing	_	_	_	_
17	arrest	arrest	NOUN	NN	Number=Sing	_	_	_	_
18	and	and	CCONJ	CC	_	_	_	_	_
19	apoptosis	apoptosis	NOUN	NN	Number=Sing	_	_	_	_
20	in	in	ADP	IN	_	_	_	_	_
21	B	b	ADJ	JJ	Degree=Pos	_	_	_	_
22	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
23	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 2903
# text = Smad6 and Smad7 prevent ligand-induced activation of signal-transducing Smad proteins in the transforming growth factor-beta family.
1	Smad6	Smad6	PROPN	NNP	Number=Sing	_	_	_	_
2	and	and	CCONJ	CC	_	_	_	_	_
3	Smad7	Smad7	NUM	CD	NumType=Card	_	_	_	_
4	prevent	prevent	ADJ	JJ	Degree=Pos	_	_	_	_
5	ligand	ligand	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
6	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
7	induced	induce	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
8	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
9	of	of	ADP	IN	_	_	_	_	_
10	signal	signal	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
11	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
12	transducing	transducing	VERB	VBG	VerbForm=Ger	_	_	_	_
13	Smad	Smad	ADJ	JJ	Degree=Pos	_	_	_	_
14	proteins	protein	NOUN	NNS	Number=Plur	_	_	_	_
15	in	in	ADP	IN	_	_	_	_	_
16	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
17	transforming	transforming	VERB	VBG	VerbForm=Ger	_	_	_	_
18	growth	growth	NOUN	NN	Number=Sing	_	_	_	_
19	factor	factor	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
20	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
21	beta	beta	NOUN	NN	Number=Sing	_	_	_	_
22	family	family	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
23	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2904
# text = Here we demonstrate that both Smad6 and Smad7 are human bone morphogenetic protein-2 (hBMP-2)-inducible antagonists of hBMP-2-induced growth arrest and apoptosis in mouse B cell hybridoma HS-72 cells.
1	Here	here	ADV	RB	PronType=Dem	_	_	_	_
2	we	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
3	demonstrate	demonstrate	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
4	that	that	SCONJ	IN	_	_	_	_	_
5	both	both	DET	DT	_	_	_	_	_
6	Smad6	smad6	NOUN	NN	Number=Sing	_	_	_	_
7	and	and	CCONJ	CC	_	_	_	_	_
8	Smad7	Smad7	NOUN	NN	Number=Sing	_	_	_	_
9	are	be	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
10	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
11	bone	bone	NOUN	NN	Number=Sing	_	_	_	_
12	morphogenetic	morphogenetic	ADJ	JJ	Degree=Pos	_	_	_	_
13	protein	protein	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
14	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
15	2	2	NUM	CD	NumType=Card	_	_	_	_
16	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
17	hBMP	hbmp	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
18	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
19	2	2	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
20	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
21	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
22	inducible	inducible	ADJ	JJ	Degree=Pos	_	_	_	_
23	antagonists	antagonist	NOUN	NNS	Number=Plur	_	_	_	_
24	of	of	ADP	IN	_	_	_	_	_
25	hBMP	hbmp	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
26	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
27	2	2	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
28	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
29	induced	induce	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
30	growth	growth	NOUN	NN	Number=Sing	_	_	_	_
31	arrest	arrest	NOUN	NN	Number=Sing	_	_	_	_
32	and	and	CCONJ	CC	_	_	_	_	_
33	apoptosis	apoptosis	NOUN	NN	Number=Sing	_	_	_	_
34	in	in	ADP	IN	_	_	_	_	_
35	mouse	mouse	NOUN	NN	Number=Sing	_	_	_	_
36	B	b	NOUN	NN	Number=Sing	_	_	_	_
37	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
38	hybridoma	hybridoma	NOUN	NN	Number=Sing	_	_	_	_
39	HS	h	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
40	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
41	72	72	NUM	CD	NumType=Card	_	_	_	_
42	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
43	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2905
# text = Moreover, we confirmed that the ectopic expressions of Smad6 and Smad7 inhibited the hBMP-2-induced Smad1/Smad5 phosphorylation.
1	Moreover	moreover	ADV	RB	_	_	_	_	SpaceAfter=No
2	,	,	PUNCT	,	_	_	_	_	_
3	we	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
4	confirmed	confirm	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
5	that	that	SCONJ	IN	_	_	_	_	_
6	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
7	ectopic	ectopic	ADJ	JJ	Degree=Pos	_	_	_	_
8	expressions	expression	NOUN	NNS	Number=Plur	_	_	_	_
9	of	of	ADP	IN	_	_	_	_	_
10	Smad6	Smad6	NUM	CD	NumType=Card	_	_	_	_
11	and	and	CCONJ	CC	_	_	_	_	_
12	Smad7	Smad7	NUM	CD	NumType=Card	_	_	_	_
13	inhibited	inhibit	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
14	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
15	hBMP	hbmp	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
16	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
17	2	2	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
18	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
19	induced	induce	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
20	Smad1	smad1	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
21	/	/	PUNCT	,	_	_	_	_	SpaceAfter=No
22	Smad5	smad5	NUM	CD	NumType=Card	_	_	_	_
23	phosphorylation	phosphorylation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
24	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2906
# text = We previously reported that Smad7 is an activin A-inducible antagonist of activin A-induced growth arrest and apoptosis in HS-72 cells.
1	We	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
2	previously	previously	ADV	RB	_	_	_	_	_
3	reported	report	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
4	that	that	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
5	Smad7	Smad7	NOUN	NN	Number=Sing	_	_	_	_
6	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
7	an	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
8	activin	activin	NOUN	NN	Number=Sing	_	_	_	_
9	A	a	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
10	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
11	inducible	inducible	ADJ	JJ	Degree=Pos	_	_	_	_
12	antagonist	antagonist	NOUN	NN	Number=Sing	_	_	_	_
13	of	of	ADP	IN	_	_	_	_	_
14	activin	activin	NOUN	NN	Number=Sing	_	_	_	_
15	A	a	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
16	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
17	induced	induce	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
18	growth	growth	NOUN	NN	Number=Sing	_	_	_	_
19	arrest	arrest	NOUN	NN	Number=Sing	_	_	_	_
20	and	and	CCONJ	CC	_	_	_	_	_
21	apoptosis	apoptosis	NOUN	NN	Number=Sing	_	_	_	_
22	in	in	ADP	IN	_	_	_	_	_
23	HS	HS	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
24	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
25	72	72	NUM	CD	NumType=Card	_	_	_	_
26	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
27	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2907
# text = Interestingly, although mRNA expression of Smad6 was induced by activin A in HS-72 cells, Smad6 showed no antagonistic effect on activin A-induced growth arrest and apoptosis.
1	Interestingly	Interestingly	ADV	RB	_	_	_	_	SpaceAfter=No
2	,	,	PUNCT	,	_	_	_	_	_
3	although	although	SCONJ	IN	_	_	_	_	_
4	mRNA	mRNA	PROPN	NNP	Number=Sing	_	_	_	_
5	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
6	of	of	ADP	IN	_	_	_	_	_
7	Smad6	smad6	PROPN	NNP	Number=Sing	_	_	_	_
8	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
9	induced	induce	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
10	by	by	ADP	IN	_	_	_	_	_
11	activin	activin	NOUN	NN	Number=Sing	_	_	_	_
12	A	a	NOUN	NN	Number=Sing	_	_	_	_
13	in	in	ADP	IN	_	_	_	_	_
14	HS	HS	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
15	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
16	72	72	NUM	CD	NumType=Card	_	_	_	_
17	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
18	,	,	PUNCT	,	_	_	_	_	_
19	Smad6	Smad6	PROPN	NNP	Number=Sing	_	_	_	_
20	showed	show	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
21	no	no	DET	DT	_	_	_	_	_
22	antagonistic	antagonistic	ADJ	JJ	Degree=Pos	_	_	_	_
23	effect	effect	NOUN	NN	Number=Sing	_	_	_	_
24	on	on	ADP	IN	_	_	_	_	_
25	activin	activin	ADP	IN	_	_	_	_	_
26	A	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	SpaceAfter=No
27	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
28	induced	induce	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
29	growth	growth	NOUN	NN	Number=Sing	_	_	_	_
30	arrest	arrest	NOUN	NN	Number=Sing	_	_	_	_
31	and	and	CCONJ	CC	_	_	_	_	_
32	apoptosis	apoptosis	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
33	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2908
# text = Moreover, we found that the ectopic expression of Smad7, but not Smad6, inhibited the activin A-induced Smad2 phosphorylation in HS-72 cells.
1	Moreover	moreover	ADV	RB	_	_	_	_	SpaceAfter=No
2	,	,	PUNCT	,	_	_	_	_	_
3	we	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
4	found	find	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
5	that	that	SCONJ	IN	_	_	_	_	_
6	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
7	ectopic	ectopic	ADJ	JJ	Degree=Pos	_	_	_	_
8	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
9	of	of	ADP	IN	_	_	_	_	_
10	Smad7	Smad7	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
11	,	,	PUNCT	,	_	_	_	_	_
12	but	but	CCONJ	CC	_	_	_	_	_
13	not	not	ADV	RB	_	_	_	_	_
14	Smad6	Smad6	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
15	,	,	PUNCT	,	_	_	_	_	_
16	inhibited	inhibit	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
17	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
18	activin	activin	NOUN	NN	Number=Sing	_	_	_	_
19	A	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	SpaceAfter=No
20	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
21	induced	induce	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
22	Smad2	smad2	NOUN	NN	Number=Sing	_	_	_	_
23	phosphorylation	phosphorylation	NOUN	NN	Number=Sing	_	_	_	_
24	in	in	ADP	IN	_	_	_	_	_
25	HS	HS	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
26	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
27	72	72	NUM	CD	NumType=Card	_	_	_	_
28	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
29	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2909
# text = Thus, Smad6 and Smad7 exhibit differential inhibitory effects in bone morphogenetic protein-2- and activin
1	Thus	thus	ADV	RB	_	_	_	_	SpaceAfter=No
2	,	,	PUNCT	,	_	_	_	_	_
3	Smad6	Smad6	NUM	CD	NumType=Card	_	_	_	_
4	and	and	CCONJ	CC	_	_	_	_	_
5	Smad7	Smad7	NUM	CD	NumType=Card	_	_	_	_
6	exhibit	exhibit	NOUN	NN	Number=Sing	_	_	_	_
7	differential	differential	ADJ	JJ	Degree=Pos	_	_	_	_
8	inhibitory	inhibitory	NOUN	NN	Number=Sing	_	_	_	_
9	effects	effect	NOUN	NNS	Number=Plur	_	_	_	_
10	in	in	ADP	IN	_	_	_	_	_
11	bone	bone	ADJ	JJ	Degree=Pos	_	_	_	_
12	morphogenetic	morphogenetic	ADJ	JJ	Degree=Pos	_	_	_	_
13	protein	protein	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
14	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
15	2	2	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
16	-	-	PUNCT	HYPH	_	_	_	_	_
17	and	and	CCONJ	CC	_	_	_	_	_
18	activin	activin	NOUN	NN	Number=Sing	_	_	_	_

# sent_id = 2910
# text = A-mediated signaling in B lineage cells.
1	A	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	SpaceAfter=No
2	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
3	mediated	mediate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
4	signaling	signaling	NOUN	NN	Number=Sing	_	_	_	_
5	in	in	ADP	IN	_	_	_	_	_
6	B	b	ADJ	JJ	Degree=Pos	_	_	_	_
7	lineage	lineage	NOUN	NN	Number=Sing	_	_	_	_
8	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
9	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 2911
# text = Document 003003344 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	003003344	003003344	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 2912
# text = The interleukin-5/receptor interaction activates Lyn and Jak2 tyrosine kinases and propagates signals via the Ras-Raf-1-MAP kinase and the Jak-STAT pathways in eosinophils.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	interleukin	interleukin	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
3	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
4	5	5	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
5	/	/	PUNCT	,	_	_	_	_	SpaceAfter=No
6	receptor	receptor	NOUN	NN	Number=Sing	_	_	_	_
7	interaction	interaction	NOUN	NN	Number=Sing	_	_	_	_
8	activates	activate	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
9	Lyn	Lyn	PROPN	NNP	Number=Sing	_	_	_	_
10	and	and	CCONJ	CC	_	_	_	_	_
11	Jak2	Jak2	NUM	CD	NumType=Card	_	_	_	_
12	tyrosine	tyrosine	NOUN	NN	Number=Sing	_	_	_	_
13	kinases	kinase	NOUN	NNS	Number=Plur	_	_	_	_
14	and	and	CCONJ	CC	_	_	_	_	_
15	propagates	propagate	NOUN	NNS	Number=Plur	_	_	_	_
16	signals	signal	NOUN	NNS	Number=Plur	_	_	_	_
17	via	via	ADP	IN	_	_	_	_	_
18	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
19	Ras	Ras	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
20	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
21	Raf	Raf	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
22	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
23	1	1	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
24	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
25	MAP	map	NOUN	NN	Number=Sing	_	_	_	_
26	kinase	kinase	NOUN	NN	Number=Sing	_	_	_	_
27	and	and	CCONJ	CC	_	_	_	_	_
28	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
29	Jak	Jak	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
30	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
31	STAT	Stat	PROPN	NNP	Number=Sing	_	_	_	_
32	pathways	pathway	NOUN	NNS	Number=Plur	_	_	_	_
33	in	in	ADP	IN	_	_	_	_	_
34	eosinophils	eosinophil	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
35	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 2913
# text = We have shown that the interaction of interleukin (IL)-5 with the receptor activates Lyn tyrosine kinase within 1 min and Jak2 tyrosine kinase within 1-3 min.
1	We	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
2	have	have	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
3	shown	show	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
4	that	that	SCONJ	IN	_	_	_	_	_
5	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
6	interaction	interaction	NOUN	NN	Number=Sing	_	_	_	_
7	of	of	ADP	IN	_	_	_	_	_
8	interleukin	interleukin	NOUN	NN	Number=Sing	_	_	_	_
9	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
10	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
11	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
12	-	-	SYM	SYM	_	_	_	_	SpaceAfter=No
13	5	5	NUM	CD	NumType=Card	_	_	_	_
14	with	with	ADP	IN	_	_	_	_	_
15	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
16	receptor	receptor	NOUN	NN	Number=Sing	_	_	_	_
17	activates	activate	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
18	Lyn	Lyn	PROPN	NNP	Number=Sing	_	_	_	_
19	tyrosine	tyrosine	NOUN	NN	Number=Sing	_	_	_	_
20	kinase	kinase	NOUN	NN	Number=Sing	_	_	_	_
21	within	within	ADP	IN	_	_	_	_	_
22	1	1	NUM	CD	NumType=Card	_	_	_	_
23	min	min	NOUN	NNS	Number=Plur	_	_	_	_
24	and	and	CCONJ	CC	_	_	_	_	_
25	Jak2	Jak2	NUM	CD	NumType=Card	_	_	_	_
26	tyrosine	tyrosine	NOUN	NN	Number=Sing	_	_	_	_
27	kinase	kinase	NOUN	NN	Number=Sing	_	_	_	_
28	within	within	ADP	IN	_	_	_	_	_
29	1	1	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
30	-	-	SYM	SYM	_	_	_	_	SpaceAfter=No
31	3	3	NUM	CD	NumType=Card	_	_	_	_
32	min	min	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
33	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2914
# text = IL-5 also stimulates GTP binding to p21ras.
1	IL	Il	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
2	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
3	5	5	NUM	CD	NumType=Card	_	_	_	_
4	also	also	ADV	RB	_	_	_	_	_
5	stimulates	stimulate	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
6	GTP	GTP	PROPN	NNP	Number=Sing	_	_	_	_
7	binding	bind	VERB	VBG	VerbForm=Ger	_	_	_	_
8	to	to	ADP	IN	_	_	_	_	_
9	p21ras	p21ra	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
10	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2915
# text = The signal is subsequently propagated through the activation of Raf-1, MEK, and MAP kinases as shown by their increased autophosphorylation in vitro and phosphorylation in situ.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	signal	signal	NOUN	NN	Number=Sing	_	_	_	_
3	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
4	subsequently	subsequently	ADV	RB	_	_	_	_	_
5	propagated	propagate	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
6	through	through	ADP	IN	_	_	_	_	_
7	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
8	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
9	of	of	ADP	IN	_	_	_	_	_
10	Raf	Raf	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
11	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
12	1	1	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
13	,	,	PUNCT	,	_	_	_	_	_
14	MEK	MEK	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
15	,	,	PUNCT	,	_	_	_	_	_
16	and	and	CCONJ	CC	_	_	_	_	_
17	MAP	map	ADJ	JJ	Degree=Pos	_	_	_	_
18	kinases	kinase	NOUN	NNS	Number=Plur	_	_	_	_
19	as	as	SCONJ	IN	_	_	_	_	_
20	shown	show	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
21	by	by	ADP	IN	_	_	_	_	_
22	their	they	PRON	PRP$	Number=Plur|Person=3|Poss=Yes|PronType=Prs	_	_	_	_
23	increased	increase	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
24	autophosphorylation	autophosphorylation	NOUN	NN	Number=Sing	_	_	_	_
25	in	in	ADP	IN	_	_	_	_	_
26	vitro	vitro	NOUN	NN	Number=Sing	_	_	_	_
27	and	and	CCONJ	CC	_	_	_	_	_
28	phosphorylation	phosphorylation	NOUN	NN	Number=Sing	_	_	_	_
29	in	in	ADP	IN	_	_	_	_	_
30	situ	situ	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
31	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2916
# text = Jak2 kinase has been shown to phosphorylate
1	Jak2	Jak2	NUM	CD	NumType=Card	_	_	_	_
2	kinase	kinase	NOUN	NN	Number=Sing	_	_	_	_
3	has	have	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
4	been	be	AUX	VBN	Tense=Past|VerbForm=Part	_	_	_	_
5	shown	show	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
6	to	to	PART	TO	_	_	_	_	_
7	phosphorylate	phosphorylate	VERB	VB	VerbForm=Inf	_	_	_	_

# sent_id = 2917
# text = STAT nuclear proteins.
1	STAT	Stat	ADJ	JJ	Degree=Pos	_	_	_	_
2	nuclear	nuclear	ADJ	JJ	Degree=Pos	_	_	_	_
3	proteins	protein	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2918
# text = The activation of STAT nuclear factors was studied by electrophoretic mobility shift assay using a gamma activation site (GAS) probe.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
3	of	of	ADP	IN	_	_	_	_	_
4	STAT	Stat	ADJ	JJ	Degree=Pos	_	_	_	_
5	nuclear	nuclear	ADJ	JJ	Degree=Pos	_	_	_	_
6	factors	factor	NOUN	NNS	Number=Plur	_	_	_	_
7	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
8	studied	study	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
9	by	by	ADP	IN	_	_	_	_	_
10	electrophoretic	electrophoretic	ADJ	JJ	Degree=Pos	_	_	_	_
11	mobility	mobility	NOUN	NN	Number=Sing	_	_	_	_
12	shift	shift	NOUN	NN	Number=Sing	_	_	_	_
13	assay	assay	NOUN	NN	Number=Sing	_	_	_	_
14	using	use	VERB	VBG	VerbForm=Ger	_	_	_	_
15	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
16	gamma	gamma	NOUN	NN	Number=Sing	_	_	_	_
17	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
18	site	site	NOUN	NN	Number=Sing	_	_	_	_
19	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
20	GAS	gas	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
21	)	)	PUNCT	-RRB-	_	_	_	_	_
22	probe	probe	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
23	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2919
# text = We found that IL-5 induces two GAS-binding proteins in eosinophils, one of which is STAT1.
1	We	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
2	found	find	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
3	that	that	SCONJ	IN	_	_	_	_	_
4	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
5	-	-	SYM	SYM	_	_	_	_	SpaceAfter=No
6	5	5	NUM	CD	NumType=Card	_	_	_	_
7	induces	induce	NOUN	NNS	Number=Plur	_	_	_	_
8	two	two	NUM	CD	NumType=Card	_	_	_	_
9	GAS	Ga	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
10	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
11	binding	bind	VERB	VBG	VerbForm=Ger	_	_	_	_
12	proteins	protein	NOUN	NNS	Number=Plur	_	_	_	_
13	in	in	ADP	IN	_	_	_	_	_
14	eosinophils	eosinophil	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
15	,	,	PUNCT	,	_	_	_	_	_
16	one	one	NUM	CD	NumType=Card	_	_	_	_
17	of	of	ADP	IN	_	_	_	_	_
18	which	which	PRON	WDT	PronType=Int	_	_	_	_
19	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
20	STAT1	STAT1	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
21	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2920
# text = We conclude that IL-5 induced signals are propagated through two distinct pathways: (1) Lyn-->Ras-->Raf-1-->MEK-->MAP kinase and (2) Jak2-->STAT1.
1	We	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
2	conclude	conclude	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
3	that	that	SCONJ	IN	_	_	_	_	_
4	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
5	-	-	SYM	SYM	_	_	_	_	SpaceAfter=No
6	5	5	NUM	CD	NumType=Card	_	_	_	_
7	induced	induced	ADJ	JJ	Degree=Pos	_	_	_	_
8	signals	signal	NOUN	NNS	Number=Plur	_	_	_	_
9	are	be	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
10	propagated	propagate	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
11	through	through	ADP	IN	_	_	_	_	_
12	two	two	NUM	CD	NumType=Card	_	_	_	_
13	distinct	distinct	ADJ	JJ	Degree=Pos	_	_	_	_
14	pathways	pathways	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
15	:	:	PUNCT	:	_	_	_	_	_
16	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
17	1	1	X	LS	_	_	_	_	SpaceAfter=No
18	)	)	PUNCT	-RRB-	_	_	_	_	_
19	Lyn	Lyn	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
20	-->	-->	PUNCT	,	_	_	_	_	SpaceAfter=No
21	Ras	Ras	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
22	-->	-->	PUNCT	,	_	_	_	_	SpaceAfter=No
23	Raf	Raf	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
24	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
25	1-->	1-->	SYM	NFP	_	_	_	_	SpaceAfter=No
26	MEK	MEK	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
27	-->	-->	SYM	NFP	_	_	_	_	SpaceAfter=No
28	MAP	map	NOUN	NN	Number=Sing	_	_	_	_
29	kinase	kinase	NOUN	NN	Number=Sing	_	_	_	_
30	and	and	CCONJ	CC	_	_	_	_	_
31	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
32	2	2	X	LS	_	_	_	_	SpaceAfter=No
33	)	)	PUNCT	-RRB-	_	_	_	_	_
34	Jak2	Jak2	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
35	-->	-->	SYM	NFP	_	_	_	_	SpaceAfter=No
36	STAT1	stat1	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
37	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 2921
# text = Document 003003345 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	003003345	003003345	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 2922
# text = Analysis of the modulation of transcriptional activity in myelopoiesis and leukemogenesis.
1	Analysis	analysis	NOUN	NN	Number=Sing	_	_	_	_
2	of	of	ADP	IN	_	_	_	_	_
3	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
4	modulation	modulation	NOUN	NN	Number=Sing	_	_	_	_
5	of	of	ADP	IN	_	_	_	_	_
6	transcriptional	transcriptional	ADJ	JJ	Degree=Pos	_	_	_	_
7	activity	activity	NOUN	NN	Number=Sing	_	_	_	_
8	in	in	ADP	IN	_	_	_	_	_
9	myelopoiesis	myelopoiesis	NOUN	NN	Number=Sing	_	_	_	_
10	and	and	CCONJ	CC	_	_	_	_	_
11	leukemogenesis	leukemogenesis	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
12	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 2923
# text = Acute myeloid leukemia (AML) is still associated with a mortality of 60 to 80%.
1	Acute	Acute	ADJ	JJ	Degree=Pos	_	_	_	_
2	myeloid	myeloid	NOUN	NN	Number=Sing	_	_	_	_
3	leukemia	leukemia	NOUN	NN	Number=Sing	_	_	_	_
4	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
5	AML	AML	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
6	)	)	PUNCT	-RRB-	_	_	_	_	_
7	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
8	still	still	ADV	RB	_	_	_	_	_
9	associated	associate	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
10	with	with	ADP	IN	_	_	_	_	_
11	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
12	mortality	mortality	NOUN	NN	Number=Sing	_	_	_	_
13	of	of	ADP	IN	_	_	_	_	_
14	60	60	NUM	CD	NumType=Card	_	_	_	_
15	to	to	ADP	IN	_	_	_	_	_
16	80%	80%	SYM	NN	Number=Sing	_	_	_	SpaceAfter=No
17	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2924
# text = AML is characterized by a block in myeloid differentiation.
1	AML	AML	ADV	RB	_	_	_	_	_
2	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
3	characterized	characterize	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
4	by	by	ADP	IN	_	_	_	_	_
5	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
6	block	block	NOUN	NN	Number=Sing	_	_	_	_
7	in	in	ADP	IN	_	_	_	_	_
8	myeloid	myeloid	ADJ	JJ	Degree=Pos	_	_	_	_
9	differentiation	differentiation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
10	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2925
# text = The transcription factors PU.1 and C/EBPalpha are responsible for normal myeloid differentiation from stem cells to monocytes or granulocytes.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
3	factors	factor	NOUN	NNS	Number=Plur	_	_	_	_
4	PU.1	PU.1	PROPN	NNP	Number=Sing	_	_	_	_
5	and	and	CCONJ	CC	_	_	_	_	_
6	C	C	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
7	/	/	PUNCT	,	_	_	_	_	SpaceAfter=No
8	EBPalpha	EBPalpha	PROPN	NNP	Number=Sing	_	_	_	_
9	are	be	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
10	responsible	responsible	ADJ	JJ	Degree=Pos	_	_	_	_
11	for	for	ADP	IN	_	_	_	_	_
12	normal	normal	ADJ	JJ	Degree=Pos	_	_	_	_
13	myeloid	myeloid	ADJ	JJ	Degree=Pos	_	_	_	_
14	differentiation	differentiation	NOUN	NN	Number=Sing	_	_	_	_
15	from	from	ADP	IN	_	_	_	_	_
16	stem	stem	NOUN	NN	Number=Sing	_	_	_	_
17	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
18	to	to	ADP	IN	_	_	_	_	_
19	monocytes	monocyte	NOUN	NNS	Number=Plur	_	_	_	_
20	or	or	CCONJ	CC	_	_	_	_	_
21	granulocytes	granulocyte	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
22	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2926
# text = In particular, PU.1 induces expression of the macrophage colony-stimulating factor (M-CSF) receptor and the development of monocytes, whereas C/EBPalpha increases the expression of the granulocyte colony-stimulating factor (G-CSF) receptor and leads to mature granulocytes.
1	In	in	ADP	IN	_	_	_	_	_
2	particular	particular	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
3	,	,	PUNCT	,	_	_	_	_	_
4	PU.1	PU.1	NUM	CD	NumType=Card	_	_	_	_
5	induces	induce	NOUN	NNS	Number=Plur	_	_	_	_
6	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
7	of	of	ADP	IN	_	_	_	_	_
8	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
9	macrophage	macrophage	NOUN	NN	Number=Sing	_	_	_	_
10	colony	colony	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
11	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
12	stimulating	stimulating	NOUN	NN	Number=Sing	_	_	_	_
13	factor	factor	NOUN	NN	Number=Sing	_	_	_	_
14	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
15	M	m	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
16	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
17	CSF	Csf	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
18	)	)	PUNCT	-RRB-	_	_	_	_	_
19	receptor	receptor	NOUN	NN	Number=Sing	_	_	_	_
20	and	and	CCONJ	CC	_	_	_	_	_
21	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
22	development	development	NOUN	NN	Number=Sing	_	_	_	_
23	of	of	ADP	IN	_	_	_	_	_
24	monocytes	monocyte	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
25	,	,	PUNCT	,	_	_	_	_	_
26	whereas	whereas	SCONJ	IN	_	_	_	_	_
27	C/	C/	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
28	EBPalpha	EBPalpha	PROPN	NNP	Number=Sing	_	_	_	_
29	increases	increase	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
30	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
31	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
32	of	of	ADP	IN	_	_	_	_	_
33	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
34	granulocyte	granulocyte	NOUN	NN	Number=Sing	_	_	_	_
35	colony	colony	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
36	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
37	stimulating	stimulating	VERB	VBG	VerbForm=Ger	_	_	_	_
38	factor	factor	NOUN	NN	Number=Sing	_	_	_	_
39	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
40	G-	G-	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
41	CSF	CSF	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
42	)	)	PUNCT	-RRB-	_	_	_	_	_
43	receptor	receptor	NOUN	NN	Number=Sing	_	_	_	_
44	and	and	CCONJ	CC	_	_	_	_	_
45	leads	lead	NOUN	NNS	Number=Plur	_	_	_	_
46	to	to	ADP	IN	_	_	_	_	_
47	mature	mature	ADJ	JJ	Degree=Pos	_	_	_	_
48	granulocytes	granulocyte	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
49	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2927
# text = In AML, chromosomal aberrations result in oncoproteins such as AML1/ETO, PML/RARalpha, or activated Ras, which can deregulate genes important for normal myelopoiesis.
1	In	in	ADP	IN	_	_	_	_	_
2	AML	aml	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
3	,	,	PUNCT	,	_	_	_	_	_
4	chromosomal	chromosomal	ADJ	JJ	Degree=Pos	_	_	_	_
5	aberrations	aberration	NOUN	NNS	Number=Plur	_	_	_	_
6	result	result	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
7	in	in	ADP	IN	_	_	_	_	_
8	oncoproteins	oncoprotein	NOUN	NNS	Number=Plur	_	_	_	_
9	such	such	ADJ	JJ	Degree=Pos	_	_	_	_
10	as	as	ADP	IN	_	_	_	_	_
11	AML1/	Aml1/	ADP	IN	Abbr=Yes	_	_	_	SpaceAfter=No
12	ETO	ETO	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
13	,	,	PUNCT	,	_	_	_	_	_
14	PML	PML	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
15	/	/	PUNCT	,	_	_	_	_	SpaceAfter=No
16	RARalpha	RARalpha	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
17	,	,	PUNCT	,	_	_	_	_	_
18	or	or	CCONJ	CC	_	_	_	_	_
19	activated	activate	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
20	Ras	Ras	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
21	,	,	PUNCT	,	_	_	_	_	_
22	which	which	PRON	WDT	PronType=Rel	_	_	_	_
23	can	can	AUX	MD	VerbForm=Fin	_	_	_	_
24	deregulate	deregulate	VERB	VB	VerbForm=Inf	_	_	_	_
25	genes	gene	NOUN	NNS	Number=Plur	_	_	_	_
26	important	important	ADJ	JJ	Degree=Pos	_	_	_	_
27	for	for	ADP	IN	_	_	_	_	_
28	normal	normal	ADJ	JJ	Degree=Pos	_	_	_	_
29	myelopoiesis	myelopoiesis	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
30	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2928
# text = Thus, AML1/ETO can bind to the transcription factor C/EBPalpha, inhibit C/EBPalpha-dependent transcription, and block granulocytic differentiation.
1	Thus	thus	ADV	RB	_	_	_	_	SpaceAfter=No
2	,	,	PUNCT	,	_	_	_	_	_
3	AML1/	AML1/	ADP	IN	Abbr=Yes	_	_	_	SpaceAfter=No
4	ETO	ETO	PROPN	NNP	Number=Sing	_	_	_	_
5	can	can	AUX	MD	VerbForm=Fin	_	_	_	_
6	bind	bind	VERB	VB	VerbForm=Inf	_	_	_	_
7	to	to	ADP	IN	_	_	_	_	_
8	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
9	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
10	factor	factor	NOUN	NN	Number=Sing	_	_	_	_
11	C	C	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
12	/	/	PUNCT	,	_	_	_	_	SpaceAfter=No
13	EBPalpha	EBPalpha	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
14	,	,	PUNCT	,	_	_	_	_	_
15	inhibit	inhibit	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
16	C/EBPalpha	C/EBPalpha	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
17	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
18	dependent	dependent	ADJ	JJ	Degree=Pos	_	_	_	_
19	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
20	,	,	PUNCT	,	_	_	_	_	_
21	and	and	CCONJ	CC	_	_	_	_	_
22	block	block	ADJ	JJ	Degree=Pos	_	_	_	_
23	granulocytic	granulocytic	ADJ	JJ	Degree=Pos	_	_	_	_
24	differentiation	differentiation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
25	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2929
# text = However, AML1/ETO can also synergize with the transcription factor AML1 to enhance the activity of the M-CSF receptor promoter.
1	However	however	ADV	RB	_	_	_	_	SpaceAfter=No
2	,	,	PUNCT	,	_	_	_	_	_
3	AML1/ETO	AML1/ETO	PROPN	NNP	Number=Sing	_	_	_	_
4	can	can	AUX	MD	VerbForm=Fin	_	_	_	_
5	also	also	ADV	RB	_	_	_	_	_
6	synergize	synergize	VERB	VB	VerbForm=Inf	_	_	_	_
7	with	with	ADP	IN	_	_	_	_	_
8	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
9	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
10	factor	factor	NOUN	NN	Number=Sing	_	_	_	_
11	AML1	Aml1	NOUN	NN	Number=Sing	_	_	_	_
12	to	to	PART	TO	_	_	_	_	_
13	enhance	enhance	VERB	VB	VerbForm=Inf	_	_	_	_
14	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
15	activity	activity	NOUN	NN	Number=Sing	_	_	_	_
16	of	of	ADP	IN	_	_	_	_	_
17	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
18	M	m	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
19	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
20	CSF	Csf	NOUN	NN	Number=Sing	_	_	_	_
21	receptor	receptor	NOUN	NN	Number=Sing	_	_	_	_
22	promoter	promoter	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
23	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2930
# text = On the other hand, the PML/RARalpha fusion protein causes transcriptional repression by recruiting the nuclear corepressor (N-CoR) histone deacetylase complex to the DNA, which results in decreased histone acetylation and a repressive chromatin organization.
1	On	on	ADP	IN	_	_	_	_	_
2	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
3	other	other	ADJ	JJ	Degree=Pos	_	_	_	_
4	hand	hand	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
5	,	,	PUNCT	,	_	_	_	_	_
6	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
7	PML	PML	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
8	/	/	PUNCT	,	_	_	_	_	SpaceAfter=No
9	RARalpha	RARalpha	PROPN	NNP	Number=Sing	_	_	_	_
10	fusion	fusion	NOUN	NN	Number=Sing	_	_	_	_
11	protein	protein	NOUN	NN	Number=Sing	_	_	_	_
12	causes	cause	NOUN	NNS	Number=Plur	_	_	_	_
13	transcriptional	transcriptional	ADJ	JJ	Degree=Pos	_	_	_	_
14	repression	repression	NOUN	NN	Number=Sing	_	_	_	_
15	by	by	SCONJ	IN	_	_	_	_	_
16	recruiting	recruit	VERB	VBG	VerbForm=Ger	_	_	_	_
17	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
18	nuclear	nuclear	ADJ	JJ	Degree=Pos	_	_	_	_
19	corepressor	corepressor	NOUN	NN	Number=Sing	_	_	_	_
20	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
21	N	and	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
22	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
23	CoR	CoR	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
24	)	)	PUNCT	-RRB-	_	_	_	_	_
25	histone	histone	NOUN	NN	Number=Sing	_	_	_	_
26	deacetylase	deacetylase	NOUN	NN	Number=Sing	_	_	_	_
27	complex	complex	NOUN	NN	Number=Sing	_	_	_	_
28	to	to	ADP	IN	_	_	_	_	_
29	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
30	DNA	dna	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
31	,	,	PUNCT	,	_	_	_	_	_
32	which	which	DET	WDT	PronType=Int	_	_	_	_
33	results	result	NOUN	NNS	Number=Plur	_	_	_	_
34	in	in	ADP	IN	_	_	_	_	_
35	decreased	decrease	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
36	histone	histone	NOUN	NN	Number=Sing	_	_	_	_
37	acetylation	acetylation	NOUN	NN	Number=Sing	_	_	_	_
38	and	and	CCONJ	CC	_	_	_	_	_
39	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
40	repressive	repressive	ADJ	JJ	Degree=Pos	_	_	_	_
41	chromatin	chromatin	NOUN	NN	Number=Sing	_	_	_	_
42	organization	organization	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
43	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2931
# text = Here we describe methods to investigate whether and how signaling agonists induce myeloid differentiation and how oncoproteins might cause AML by modulating the activity of transcription factors that are pivotal for normal myeloid development.
1	Here	here	ADV	RB	PronType=Dem	_	_	_	_
2	we	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
3	describe	describe	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
4	methods	method	NOUN	NNS	Number=Plur	_	_	_	_
5	to	to	PART	TO	_	_	_	_	_
6	investigate	investigate	VERB	VB	VerbForm=Inf	_	_	_	_
7	whether	whether	SCONJ	IN	_	_	_	_	_
8	and	and	CCONJ	CC	_	_	_	_	_
9	how	how	ADV	WRB	PronType=Int	_	_	_	_
10	signaling	signal	VERB	VBG	VerbForm=Ger	_	_	_	_
11	agonists	agonist	NOUN	NNS	Number=Plur	_	_	_	_
12	induce	induce	ADV	RB	_	_	_	_	_
13	myeloid	myeloid	ADJ	JJ	Degree=Pos	_	_	_	_
14	differentiation	differentiation	NOUN	NN	Number=Sing	_	_	_	_
15	and	and	CCONJ	CC	_	_	_	_	_
16	how	how	ADV	WRB	PronType=Int	_	_	_	_
17	oncoproteins	oncoprotein	NOUN	NNS	Number=Plur	_	_	_	_
18	might	might	AUX	MD	VerbForm=Fin	_	_	_	_
19	cause	cause	VERB	VB	VerbForm=Inf	_	_	_	_
20	AML	AML	ADV	RB	_	_	_	_	_
21	by	by	SCONJ	IN	_	_	_	_	_
22	modulating	modulat	VERB	VBG	VerbForm=Ger	_	_	_	_
23	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
24	activity	activity	NOUN	NN	Number=Sing	_	_	_	_
25	of	of	ADP	IN	_	_	_	_	_
26	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
27	factors	factor	NOUN	NNS	Number=Plur	_	_	_	_
28	that	that	PRON	WDT	PronType=Rel	_	_	_	_
29	are	be	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
30	pivotal	pivotal	ADJ	JJ	Degree=Pos	_	_	_	_
31	for	for	ADP	IN	_	_	_	_	_
32	normal	normal	ADJ	JJ	Degree=Pos	_	_	_	_
33	myeloid	myeloid	ADJ	JJ	Degree=Pos	_	_	_	_
34	development	development	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
35	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2932
# text = Copyright 1999 Academic Press.
1	Copyright	copyright	NOUN	NN	Number=Sing	_	_	_	_
2	1999	1999	NUM	CD	NumType=Card	_	_	_	_
3	Academic	academic	PROPN	NNP	Number=Sing	_	_	_	_
4	Press.	Press.	PROPN	NNP	Number=Sing	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 2933
# text = Document 003003348 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	003003348	003003348	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 2934
# text = Interferon-beta mediates stromal cell rescue of T cells from apoptosis.
1	Interferon	Interferon	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
2	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
3	beta	beta	NOUN	NN	Number=Sing	_	_	_	_
4	mediates	mediate	NOUN	NNS	Number=Plur	_	_	_	_
5	stromal	stromal	ADJ	JJ	Degree=Pos	_	_	_	_
6	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
7	rescue	rescue	NOUN	NN	Number=Sing	_	_	_	_
8	of	of	ADP	IN	_	_	_	_	_
9	T	t	PROPN	NNP	Number=Sing	_	_	_	_
10	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
11	from	from	ADP	IN	_	_	_	_	_
12	apoptosis	apoptosis	PRON	DT	Number=Sing|PronType=Dem	_	_	_	SpaceAfter=No
13	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 2935
# text = The resolution of immune responses is characterized by extensive apoptosis of activated T cells.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	resolution	resolution	NOUN	NN	Number=Sing	_	_	_	_
3	of	of	ADP	IN	_	_	_	_	_
4	immune	immune	ADJ	JJ	Degree=Pos	_	_	_	_
5	responses	response	NOUN	NNS	Number=Plur	_	_	_	_
6	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
7	characterized	characterize	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
8	by	by	ADP	IN	_	_	_	_	_
9	extensive	extensive	ADJ	JJ	Degree=Pos	_	_	_	_
10	apoptosis	apoptosis	NOUN	NN	Number=Sing	_	_	_	_
11	of	of	ADP	IN	_	_	_	_	_
12	activated	activate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
13	T	t	PROPN	NNP	Number=Sing	_	_	_	_
14	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
15	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2936
# text = However, to generate and maintain immunological memory, some antigen-specific T cells must survive and revert to a resting G0/G1 state.
1	However	however	ADV	RB	_	_	_	_	SpaceAfter=No
2	,	,	PUNCT	,	_	_	_	_	_
3	to	to	PART	TO	_	_	_	_	_
4	generate	generate	VERB	VB	VerbForm=Inf	_	_	_	_
5	and	and	CCONJ	CC	_	_	_	_	_
6	maintain	maintain	VERB	VB	VerbForm=Inf	_	_	_	_
7	immunological	immunological	ADJ	JJ	Degree=Pos	_	_	_	_
8	memory	memory	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
9	,	,	PUNCT	,	_	_	_	_	_
10	some	some	DET	DT	_	_	_	_	_
11	antigen-specific	antigen-specific	ADJ	JJ	Degree=Pos	_	_	_	_
12	T	t	PROPN	NNP	Number=Sing	_	_	_	_
13	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
14	must	must	AUX	MD	VerbForm=Fin	_	_	_	_
15	survive	survive	VERB	VB	VerbForm=Inf	_	_	_	_
16	and	and	CCONJ	CC	_	_	_	_	_
17	revert	revert	VERB	VB	VerbForm=Inf	_	_	_	_
18	to	to	ADP	IN	_	_	_	_	_
19	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
20	resting	reste	VERB	VBG	VerbForm=Ger	_	_	_	_
21	G0/G1	G0/g1	NOUN	NN	Number=Sing	_	_	_	_
22	state	state	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
23	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2937
# text = Cytokines that bind to the common gamma chain of the IL-2 receptor promote the survival of T cell blasts, but also induce proliferation.
1	Cytokines	Cytokine	NOUN	NNS	Number=Plur	_	_	_	_
2	that	that	PRON	WDT	PronType=Rel	_	_	_	_
3	bind	bind	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
4	to	to	ADP	IN	_	_	_	_	_
5	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
6	common	common	ADJ	JJ	Degree=Pos	_	_	_	_
7	gamma	gamma	NOUN	NN	Number=Sing	_	_	_	_
8	chain	chain	NOUN	NN	Number=Sing	_	_	_	_
9	of	of	ADP	IN	_	_	_	_	_
10	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
11	IL	Il	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
12	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
13	2	2	NUM	CD	NumType=Card	_	_	_	_
14	receptor	receptor	NOUN	NN	Number=Sing	_	_	_	_
15	promote	promote	VERB	VB	VerbForm=Inf	_	_	_	_
16	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
17	survival	survival	NOUN	NN	Number=Sing	_	_	_	_
18	of	of	ADP	IN	_	_	_	_	_
19	T	t	PROPN	NNP	Number=Sing	_	_	_	_
20	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
21	blasts	blast	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
22	,	,	PUNCT	,	_	_	_	_	_
23	but	but	CCONJ	CC	_	_	_	_	_
24	also	also	ADV	RB	_	_	_	_	_
25	induce	induce	ADJ	JJ	Degree=Pos	_	_	_	_
26	proliferation	proliferation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
27	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2938
# text = In contrast, soluble factors secreted by stromal cells induce
1	In	in	ADP	IN	_	_	_	_	_
2	contrast	contrast	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
3	,	,	PUNCT	,	_	_	_	_	_
4	soluble	soluble	ADJ	JJ	Degree=Pos	_	_	_	_
5	factors	factor	NOUN	NNS	Number=Plur	_	_	_	_
6	secreted	secret	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
7	by	by	ADP	IN	_	_	_	_	_
8	stromal	stromal	ADJ	JJ	Degree=Pos	_	_	_	_
9	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
10	induce	induce	NOUN	NN	Number=Sing	_	_	_	_

# sent_id = 2939
# text = Tcell survival in a resting G0/G1 state.
1	Tcell	Tcell	VERB	VB	Mood=Imp|VerbForm=Fin	_	_	_	_
2	survival	survival	NOUN	NN	Number=Sing	_	_	_	_
3	in	in	ADP	IN	_	_	_	_	_
4	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
5	resting	resting	NOUN	NN	Number=Sing	_	_	_	_
6	G0/G1	G0/G1	NUM	CD	NumType=Card	_	_	_	_
7	state	state	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
8	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2940
# text = We now report that interferon-beta is the principal mediator of stromal cell-mediated
1	We	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
2	now	now	ADV	RB	_	_	_	_	_
3	report	report	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
4	that	that	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
5	interferon	interferon	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
6	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
7	beta	beta	NOUN	NN	Number=Sing	_	_	_	_
8	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
9	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
10	principal	principal	NOUN	NN	Number=Sing	_	_	_	_
11	mediator	mediator	NOUN	NN	Number=Sing	_	_	_	_
12	of	of	ADP	IN	_	_	_	_	_
13	stromal	stromal	ADJ	JJ	Degree=Pos	_	_	_	_
14	cell	cell	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
15	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
16	mediated	mediate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_

# sent_id = 2941
# text = Tcell rescue from apoptosis.
1	Tcell	Tcell	ADJ	JJ	Degree=Pos	_	_	_	_
2	rescue	rescue	NOUN	NN	Number=Sing	_	_	_	_
3	from	from	ADP	IN	_	_	_	_	_
4	apoptosis	apoptosis	PRON	DT	Number=Sing|PronType=Dem	_	_	_	SpaceAfter=No
5	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2942
# text = Interferon-alpha and -beta promote the reversion of blast Tcells to a resting G0/G1 configuration with all the characteristic features of stromal cell rescue; such as high Bcl-XL expression and low Bcl-2.
1	Interferon	Interferon	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
2	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
3	alpha	alpha	NOUN	NN	Number=Sing	_	_	_	_
4	and	and	CCONJ	CC	_	_	_	_	_
5	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
6	beta	beta	PART	TO	Abbr=Yes	_	_	_	_
7	promote	promote	VERB	VB	VerbForm=Inf	_	_	_	_
8	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
9	reversion	reversion	NOUN	NN	Number=Sing	_	_	_	_
10	of	of	ADP	IN	_	_	_	_	_
11	blast	blast	ADJ	JJ	Degree=Pos	_	_	_	_
12	Tcells	Tcell	NOUN	NNS	Number=Plur	_	_	_	_
13	to	to	ADP	IN	_	_	_	_	_
14	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
15	resting	reste	VERB	VBG	VerbForm=Ger	_	_	_	_
16	G0/G1	G0/g1	NOUN	NN	Number=Sing	_	_	_	_
17	configuration	configuration	NOUN	NN	Number=Sing	_	_	_	_
18	with	with	ADP	IN	_	_	_	_	_
19	all	all	DET	PDT	_	_	_	_	_
20	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
21	characteristic	characteristic	ADJ	JJ	Degree=Pos	_	_	_	_
22	features	feature	NOUN	NNS	Number=Plur	_	_	_	_
23	of	of	ADP	IN	_	_	_	_	_
24	stromal	stromal	ADJ	JJ	Degree=Pos	_	_	_	_
25	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
26	rescue	rescue	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
27	;	;	PUNCT	,	_	_	_	_	_
28	such	such	ADJ	JJ	Degree=Pos	_	_	_	_
29	as	as	ADP	IN	_	_	_	_	_
30	high	high	ADJ	JJ	Degree=Pos	_	_	_	_
31	Bcl	Bcl	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
32	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
33	XL	XL	PROPN	NNP	Number=Sing	_	_	_	_
34	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
35	and	and	CCONJ	CC	_	_	_	_	_
36	low	low	ADJ	JJ	Degree=Pos	_	_	_	_
37	Bcl	Bcl	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
38	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
39	2	2	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
40	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2943
# text = Type I interferons and stromal cells stimulate apparently identical signaling pathways, leading to STAT-1 activation.
1	Type	type	NOUN	NN	Number=Sing	_	_	_	_
2	I	I	PRON	PRP	Case=Nom|Number=Sing|Person=1|PronType=Prs	_	_	_	_
3	interferons	interferon	NOUN	NNS	Number=Plur	_	_	_	_
4	and	and	CCONJ	CC	_	_	_	_	_
5	stromal	stromal	ADJ	JJ	Degree=Pos	_	_	_	_
6	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
7	stimulate	stimulate	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
8	apparently	apparently	ADV	RB	_	_	_	_	_
9	identical	identical	ADJ	JJ	Degree=Pos	_	_	_	_
10	signaling	signaling	NOUN	NN	Number=Sing	_	_	_	_
11	pathways	pathway	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
12	,	,	PUNCT	,	_	_	_	_	_
13	leading	lead	VERB	VBG	VerbForm=Ger	_	_	_	_
14	to	to	ADP	IN	_	_	_	_	_
15	STAT	STAT	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
16	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
17	1	1	NUM	CD	NumType=Card	_	_	_	_
18	activation	activation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
19	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2944
# text = We also show that this mechanism may play a fundamental role in the persistence of T cells at sites of chronic inflammation; suggesting that chronic inflammation is an aberrant consequence of immunological memory.
1	We	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
2	also	also	ADV	RB	_	_	_	_	_
3	show	show	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
4	that	that	SCONJ	IN	_	_	_	_	_
5	this	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
6	mechanism	mechanism	NOUN	NN	Number=Sing	_	_	_	_
7	may	may	AUX	MD	VerbForm=Fin	_	_	_	_
8	play	play	VERB	VB	VerbForm=Inf	_	_	_	_
9	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
10	fundamental	fundamental	ADJ	JJ	Degree=Pos	_	_	_	_
11	role	role	NOUN	NN	Number=Sing	_	_	_	_
12	in	in	ADP	IN	_	_	_	_	_
13	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
14	persistence	persistence	NOUN	NN	Number=Sing	_	_	_	_
15	of	of	ADP	IN	_	_	_	_	_
16	T	t	PROPN	NNP	Number=Sing	_	_	_	_
17	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
18	at	at	ADP	IN	_	_	_	_	_
19	sites	site	NOUN	NNS	Number=Plur	_	_	_	_
20	of	of	ADP	IN	_	_	_	_	_
21	chronic	chronic	ADJ	JJ	Degree=Pos	_	_	_	_
22	inflammation	inflammation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
23	;	;	PUNCT	,	_	_	_	_	_
24	suggesting	suggest	VERB	VBG	VerbForm=Ger	_	_	_	_
25	that	that	SCONJ	IN	_	_	_	_	_
26	chronic	chronic	ADJ	JJ	Degree=Pos	_	_	_	_
27	inflammation	inflammation	NOUN	NN	Number=Sing	_	_	_	_
28	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
29	an	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
30	aberrant	aberrant	ADJ	JJ	Degree=Pos	_	_	_	_
31	consequence	consequence	NOUN	NN	Number=Sing	_	_	_	_
32	of	of	ADP	IN	_	_	_	_	_
33	immunological	immunological	ADJ	JJ	Degree=Pos	_	_	_	_
34	memory	memory	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
35	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 2945
# text = Document 003003351 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	003003351	003003351	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 2946
# text = Effects of intranasal glucocorticoids on endogenous glucocorticoid peripheral and central function.
1	Effects	Effects	NOUN	NNS	Number=Plur	_	_	_	_
2	of	of	ADP	IN	_	_	_	_	_
3	intranasal	intranasal	ADJ	JJ	Degree=Pos	_	_	_	_
4	glucocorticoids	glucocorticoid	NOUN	NNS	Number=Plur	_	_	_	_
5	on	on	ADP	IN	_	_	_	_	_
6	endogenous	endogenous	ADJ	JJ	Degree=Pos	_	_	_	_
7	glucocorticoid	glucocorticoid	NOUN	NN	Number=Sing	_	_	_	_
8	peripheral	peripheral	ADJ	JJ	Degree=Pos	_	_	_	_
9	and	and	CCONJ	CC	_	_	_	_	_
10	central	central	ADJ	JJ	Degree=Pos	_	_	_	_
11	function	function	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
12	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 2947
# text = Glucocorticoids are among the most potent antiinflammatory agents that can be used in the treatment of rhinitis.
1	Glucocorticoids	Glucocorticoid	NOUN	NNS	Number=Plur	_	_	_	_
2	are	be	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
3	among	among	ADP	IN	_	_	_	_	_
4	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
5	most	most	ADV	RBS	_	_	_	_	_
6	potent	potent	ADJ	JJ	Degree=Pos	_	_	_	_
7	antiinflammatory	antiinflammatory	ADJ	JJ	Degree=Pos	_	_	_	_
8	agents	agent	NOUN	NNS	Number=Plur	_	_	_	_
9	that	that	PRON	WDT	PronType=Rel	_	_	_	_
10	can	can	AUX	MD	VerbForm=Fin	_	_	_	_
11	be	be	AUX	VB	VerbForm=Inf	_	_	_	_
12	used	use	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
13	in	in	ADP	IN	_	_	_	_	_
14	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
15	treatment	treatment	NOUN	NN	Number=Sing	_	_	_	_
16	of	of	ADP	IN	_	_	_	_	_
17	rhinitis	rhinitis	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
18	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2948
# text = Their mechanisms of action are multiple and complex and a number of reports describe significant systemic effects of locally administered glucocorticoids.
1	Their	they	PRON	PRP$	Number=Plur|Person=3|Poss=Yes|PronType=Prs	_	_	_	_
2	mechanisms	mechanism	NOUN	NNS	Number=Plur	_	_	_	_
3	of	of	ADP	IN	_	_	_	_	_
4	action	action	NOUN	NN	Number=Sing	_	_	_	_
5	are	be	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
6	multiple	multiple	ADJ	JJ	Degree=Pos	_	_	_	_
7	and	and	CCONJ	CC	_	_	_	_	_
8	complex	complex	ADJ	JJ	Degree=Pos	_	_	_	_
9	and	and	CCONJ	CC	_	_	_	_	_
10	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
11	number	number	NOUN	NN	Number=Sing	_	_	_	_
12	of	of	ADP	IN	_	_	_	_	_
13	reports	report	NOUN	NNS	Number=Plur	_	_	_	_
14	describe	describe	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
15	significant	significant	ADJ	JJ	Degree=Pos	_	_	_	_
16	systemic	systemic	ADJ	JJ	Degree=Pos	_	_	_	_
17	effects	effect	NOUN	NNS	Number=Plur	_	_	_	_
18	of	of	ADP	IN	_	_	_	_	_
19	locally	locally	ADV	RB	_	_	_	_	_
20	administered	administer	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
21	glucocorticoids	glucocorticoid	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
22	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2949
# text = In order to evaluate the short-term systemic effects of intranasally administered glucocorticoids, 14 normal healthy subjects were treated with two doses of either budesonide (BUD) or fluticasone propionate (FP) for 2 weeks.
1	In	in	ADP	IN	_	_	_	_	_
2	order	order	NOUN	NN	Number=Sing	_	_	_	_
3	to	to	PART	TO	_	_	_	_	_
4	evaluate	evaluate	VERB	VB	VerbForm=Inf	_	_	_	_
5	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
6	short	short	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
7	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
8	term	term	NOUN	NN	Number=Sing	_	_	_	_
9	systemic	systemic	NOUN	NN	Number=Sing	_	_	_	_
10	effects	effect	NOUN	NNS	Number=Plur	_	_	_	_
11	of	of	ADP	IN	_	_	_	_	_
12	intranasally	intranasally	ADV	RB	_	_	_	_	_
13	administered	administer	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
14	glucocorticoids	glucocorticoid	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
15	,	,	PUNCT	,	_	_	_	_	_
16	14	14	NUM	CD	NumType=Card	_	_	_	_
17	normal	normal	ADJ	JJ	Degree=Pos	_	_	_	_
18	healthy	healthy	ADJ	JJ	Degree=Pos	_	_	_	_
19	subjects	subject	NOUN	NNS	Number=Plur	_	_	_	_
20	were	be	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
21	treated	treat	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
22	with	with	ADP	IN	_	_	_	_	_
23	two	two	NUM	CD	NumType=Card	_	_	_	_
24	doses	dos	NOUN	NNS	Number=Plur	_	_	_	_
25	of	of	ADP	IN	_	_	_	_	_
26	either	either	DET	DT	_	_	_	_	_
27	budesonide	budesonide	NOUN	NN	Number=Sing	_	_	_	_
28	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
29	BUD	Bud	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
30	)	)	PUNCT	-RRB-	_	_	_	_	_
31	or	or	CCONJ	CC	_	_	_	_	_
32	fluticasone	fluticasone	PRON	NN	Number=Sing	_	_	_	_
33	propionate	propionate	ADJ	JJ	Degree=Pos	_	_	_	_
34	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
35	FP	FP	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
36	)	)	PUNCT	-RRB-	_	_	_	_	_
37	for	for	ADP	IN	_	_	_	_	_
38	2	2	NUM	CD	NumType=Card	_	_	_	_
39	weeks	week	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
40	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2950
# text = Before treatment, at regular intervals during the treatment, 1 week and finally 6 weeks after termination of treatment, the effects on glucocorticoid receptor (GR) and methallothionein (MTIIa) mRNA expression levels were examined in peripheral lymphocytes using a solution hybridization assay.
1	Before	before	ADP	IN	_	_	_	_	_
2	treatment	treatment	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
3	,	,	PUNCT	,	_	_	_	_	_
4	at	at	ADP	IN	_	_	_	_	_
5	regular	regular	ADJ	JJ	Degree=Pos	_	_	_	_
6	intervals	interval	NOUN	NNS	Number=Plur	_	_	_	_
7	during	during	ADP	IN	_	_	_	_	_
8	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
9	treatment	treatment	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
10	,	,	PUNCT	,	_	_	_	_	_
11	1	1	NUM	CD	NumType=Card	_	_	_	_
12	week	week	NOUN	NN	Number=Sing	_	_	_	_
13	and	and	CCONJ	CC	_	_	_	_	_
14	finally	finally	ADV	RB	_	_	_	_	_
15	6	6	NUM	CD	NumType=Card	_	_	_	_
16	weeks	week	NOUN	NNS	Number=Plur	_	_	_	_
17	after	after	ADP	IN	_	_	_	_	_
18	termination	termination	NOUN	NN	Number=Sing	_	_	_	_
19	of	of	ADP	IN	_	_	_	_	_
20	treatment	treatment	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
21	,	,	PUNCT	,	_	_	_	_	_
22	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
23	effects	effect	NOUN	NNS	Number=Plur	_	_	_	_
24	on	on	ADP	IN	_	_	_	_	_
25	glucocorticoid	glucocorticoid	ADJ	JJ	Degree=Pos	_	_	_	_
26	receptor	receptor	NOUN	NN	Number=Sing	_	_	_	_
27	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
28	GR	GR	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
29	)	)	PUNCT	-RRB-	_	_	_	_	_
30	and	and	CCONJ	CC	_	_	_	_	_
31	methallothionein	methallothionein	NOUN	NN	Number=Sing	_	_	_	_
32	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
33	MTIIa	MTIIa	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
34	)	)	PUNCT	-RRB-	_	_	_	_	_
35	mRNA	mRNa	PROPN	NNP	Number=Sing	_	_	_	_
36	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
37	levels	level	NOUN	NNS	Number=Plur	_	_	_	_
38	were	be	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
39	examined	examin	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
40	in	in	ADP	IN	_	_	_	_	_
41	peripheral	peripheral	ADJ	JJ	Degree=Pos	_	_	_	_
42	lymphocytes	lymphocyte	NOUN	NNS	Number=Plur	_	_	_	_
43	using	use	VERB	VBG	VerbForm=Ger	_	_	_	_
44	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
45	solution	solution	NOUN	NN	Number=Sing	_	_	_	_
46	hybridization	hybridization	NOUN	NN	Number=Sing	_	_	_	_
47	assay	assay	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
48	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2951
# text = Serum cortisol, osteocalcin and urinary cortisol levels were also determined.
1	Serum	Serum	NOUN	NN	Number=Sing	_	_	_	_
2	cortisol	cortisol	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
3	,	,	PUNCT	,	_	_	_	_	_
4	osteocalcin	osteocalcin	ADJ	JJ	Degree=Pos	_	_	_	_
5	and	and	CCONJ	CC	_	_	_	_	_
6	urinary	urinary	ADJ	JJ	Degree=Pos	_	_	_	_
7	cortisol	cortisol	NOUN	NN	Number=Sing	_	_	_	_
8	levels	level	NOUN	NNS	Number=Plur	_	_	_	_
9	were	be	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
10	also	also	ADV	RB	_	_	_	_	_
11	determined	determined	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
12	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2952
# text = An insulin tolerance test (ITT) was performed at the end of the second week of treatment and at the end of the 6-week washout period with no statistically significant change in cortisol response.
1	An	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
2	insulin	insulin	ADJ	JJ	Degree=Pos	_	_	_	_
3	tolerance	tolerance	NOUN	NN	Number=Sing	_	_	_	_
4	test	test	NOUN	NN	Number=Sing	_	_	_	_
5	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
6	ITT	ITT	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
7	)	)	PUNCT	-RRB-	_	_	_	_	_
8	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
9	performed	perform	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
10	at	at	ADP	IN	_	_	_	_	_
11	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
12	end	end	NOUN	NN	Number=Sing	_	_	_	_
13	of	of	ADP	IN	_	_	_	_	_
14	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
15	second	second	ADJ	JJ	Degree=Pos|NumType=Ord	_	_	_	_
16	week	week	NOUN	NN	Number=Sing	_	_	_	_
17	of	of	ADP	IN	_	_	_	_	_
18	treatment	treatment	NOUN	NN	Number=Sing	_	_	_	_
19	and	and	CCONJ	CC	_	_	_	_	_
20	at	at	ADP	IN	_	_	_	_	_
21	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
22	end	end	NOUN	NN	Number=Sing	_	_	_	_
23	of	of	ADP	IN	_	_	_	_	_
24	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
25	6	6	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
26	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
27	week	week	NOUN	NN	Number=Sing	_	_	_	_
28	washout	washout	ADP	IN	_	_	_	_	_
29	period	period	NOUN	NN	Number=Sing	_	_	_	_
30	with	with	ADP	IN	_	_	_	_	_
31	no	no	DET	DT	_	_	_	_	_
32	statistically	statistically	ADV	RB	_	_	_	_	_
33	significant	significant	ADJ	JJ	Degree=Pos	_	_	_	_
34	change	change	NOUN	NN	Number=Sing	_	_	_	_
35	in	in	ADP	IN	_	_	_	_	_
36	cortisol	cortisol	ADJ	JJ	Degree=Pos	_	_	_	_
37	response	response	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
38	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2953
# text = In peripheral lymphocytes, GR mRNA levels were significantly down-regulated.
1	In	in	ADP	IN	_	_	_	_	_
2	peripheral	peripheral	ADJ	JJ	Degree=Pos	_	_	_	_
3	lymphocytes	lymphocyte	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	,	,	PUNCT	,	_	_	_	_	_
5	GR	Gr	PROPN	NNP	Number=Sing	_	_	_	_
6	mRNA	mRNa	PROPN	NNP	Number=Sing	_	_	_	_
7	levels	level	NOUN	NNS	Number=Plur	_	_	_	_
8	were	be	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
9	significantly	significantly	ADV	RB	_	_	_	_	_
10	down	down	ADV	RB	_	_	_	_	SpaceAfter=No
11	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
12	regulated	regulate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	SpaceAfter=No
13	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2954
# text = MTIIa mRNA levels increased significantly.
1	MTIIa	MTIIa	PROPN	NNP	Number=Sing	_	_	_	_
2	mRNA	mRNA	PROPN	NNP	Number=Sing	_	_	_	_
3	levels	level	NOUN	NNS	Number=Plur	_	_	_	_
4	increased	increase	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
5	significantly	significantly	ADV	RB	_	_	_	_	SpaceAfter=No
6	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2955
# text = Serum osteocalcin decreased significantly during treatment with both BUD and FP.
1	Serum	Serum	PROPN	NNP	Number=Sing	_	_	_	_
2	osteocalcin	osteocalcin	ADV	RB	_	_	_	_	_
3	decreased	decrease	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
4	significantly	significantly	ADV	RB	_	_	_	_	_
5	during	during	ADP	IN	_	_	_	_	_
6	treatment	treatment	NOUN	NN	Number=Sing	_	_	_	_
7	with	with	ADP	IN	_	_	_	_	_
8	both	both	CCONJ	CC	_	_	_	_	_
9	BUD	Bud	PROPN	NNP	Number=Sing	_	_	_	_
10	and	and	CCONJ	CC	_	_	_	_	_
11	FP	FP	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
12	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2956
# text = Serum cortisol decreased after 1 week of treatment whereas urinary cortisol was not affected until the second week of treatment.
1	Serum	Serum	PROPN	NNP	Number=Sing	_	_	_	_
2	cortisol	cortisol	NOUN	NN	Number=Sing	_	_	_	_
3	decreased	decrease	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
4	after	after	ADP	IN	_	_	_	_	_
5	1	1	NUM	CD	NumType=Card	_	_	_	_
6	week	week	NOUN	NN	Number=Sing	_	_	_	_
7	of	of	ADP	IN	_	_	_	_	_
8	treatment	treatment	NOUN	NN	Number=Sing	_	_	_	_
9	whereas	wherea	SCONJ	IN	_	_	_	_	_
10	urinary	urinary	ADJ	JJ	Degree=Pos	_	_	_	_
11	cortisol	cortisol	NOUN	NN	Number=Sing	_	_	_	_
12	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
13	not	not	PART	RB	_	_	_	_	_
14	affected	affect	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
15	until	until	ADP	IN	_	_	_	_	_
16	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
17	second	second	ADJ	JJ	Degree=Pos|NumType=Ord	_	_	_	_
18	week	week	NOUN	NN	Number=Sing	_	_	_	_
19	of	of	ADP	IN	_	_	_	_	_
20	treatment	treatment	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
21	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2957
# text = In conclusion, intranasal glucocorticoids at clinically recommended doses have not only significant systemic effects on adrenal function, but also have an effect on specific gene expression in peripheral lymphocytes.
1	In	in	ADP	IN	_	_	_	_	_
2	conclusion	conclusion	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
3	,	,	PUNCT	,	_	_	_	_	_
4	intranasal	intranasal	ADJ	JJ	Degree=Pos	_	_	_	_
5	glucocorticoids	glucocorticoid	NOUN	NNS	Number=Plur	_	_	_	_
6	at	at	ADP	IN	_	_	_	_	_
7	clinically	clinically	ADV	RB	_	_	_	_	_
8	recommended	recommend	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
9	doses	dos	NOUN	NNS	Number=Plur	_	_	_	_
10	have	have	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
11	not	not	ADV	RB	_	_	_	_	_
12	only	only	ADV	RB	_	_	_	_	_
13	significant	significant	ADJ	JJ	Degree=Pos	_	_	_	_
14	systemic	systemic	ADJ	JJ	Degree=Pos	_	_	_	_
15	effects	effect	NOUN	NNS	Number=Plur	_	_	_	_
16	on	on	ADP	IN	_	_	_	_	_
17	adrenal	adrenal	ADJ	JJ	Degree=Pos	_	_	_	_
18	function	function	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
19	,	,	PUNCT	,	_	_	_	_	_
20	but	but	CCONJ	CC	_	_	_	_	_
21	also	also	ADV	RB	_	_	_	_	_
22	have	have	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
23	an	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
24	effect	effect	NOUN	NN	Number=Sing	_	_	_	_
25	on	on	ADP	IN	_	_	_	_	_
26	specific	specific	ADJ	JJ	Degree=Pos	_	_	_	_
27	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
28	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
29	in	in	ADP	IN	_	_	_	_	_
30	peripheral	peripheral	ADJ	JJ	Degree=Pos	_	_	_	_
31	lymphocytes	lymphocyte	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
32	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2958
# text = These effects are receptor-dependent, reversible, and according to serum and urinary cortisol levels and ITT, leave the hypothalamic-pituitary-adrenal function intact.
1	These	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
2	effects	effect	NOUN	NNS	Number=Plur	_	_	_	_
3	are	be	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
4	receptor	receptor	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
5	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
6	dependent	dependent	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
7	,	,	PUNCT	,	_	_	_	_	_
8	reversible	reversible	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
9	,	,	PUNCT	,	_	_	_	_	_
10	and	and	CCONJ	CC	_	_	_	_	_
11	according	accord	VERB	VBG	VerbForm=Ger	_	_	_	_
12	to	to	ADP	IN	_	_	_	_	_
13	serum	serum	NOUN	NN	Number=Sing	_	_	_	_
14	and	and	CCONJ	CC	_	_	_	_	_
15	urinary	urinary	ADJ	JJ	Degree=Pos	_	_	_	_
16	cortisol	cortisol	NOUN	NN	Number=Sing	_	_	_	_
17	levels	level	NOUN	NNS	Number=Plur	_	_	_	_
18	and	and	CCONJ	CC	_	_	_	_	_
19	ITT	Itt	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
20	,	,	PUNCT	,	_	_	_	_	_
21	leave	leave	VERB	VB	Mood=Imp|VerbForm=Fin	_	_	_	_
22	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
23	hypothalamic	hypothalamic	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
24	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
25	pituitary	pituitary	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
26	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
27	adrenal	adrenal	ADJ	JJ	Degree=Pos	_	_	_	_
28	function	function	NOUN	NN	Number=Sing	_	_	_	_
29	intact	intact	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
30	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2959
# text = Finally, these short-term systemic effects were not associated with any of the noticeable side-effects usually observed during long-term treatment with glucocorticoids.
1	Finally	finally	ADV	RB	_	_	_	_	SpaceAfter=No
2	,	,	PUNCT	,	_	_	_	_	_
3	these	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
4	short	short	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
5	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
6	term	term	NOUN	NN	Number=Sing	_	_	_	_
7	systemic	systemic	ADJ	JJ	Degree=Pos	_	_	_	_
8	effects	effect	NOUN	NNS	Number=Plur	_	_	_	_
9	were	be	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
10	not	not	PART	RB	_	_	_	_	_
11	associated	associate	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
12	with	with	ADP	IN	_	_	_	_	_
13	any	any	DET	DT	_	_	_	_	_
14	of	of	ADP	IN	_	_	_	_	_
15	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
16	noticeable	noticeable	ADJ	JJ	Degree=Pos	_	_	_	_
17	side	side	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
18	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
19	effects	effect	NOUN	NNS	Number=Plur	_	_	_	_
20	usually	usually	ADV	RB	_	_	_	_	_
21	observed	observe	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
22	during	during	ADP	IN	_	_	_	_	_
23	long	long	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
24	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
25	term	term	NOUN	NN	Number=Sing	_	_	_	_
26	treatment	treatment	NOUN	NN	Number=Sing	_	_	_	_
27	with	with	ADP	IN	_	_	_	_	_
28	glucocorticoids	glucocorticoid	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
29	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 2960
# text = Document 003003354 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	003003354	003003354	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 2961
# text = Association of the interleukin-4 receptor alpha chain with p47phox, an activator of the phagocyte NADPH oxidase in B cells.
1	Association	Association	NOUN	NN	Number=Sing	_	_	_	_
2	of	of	ADP	IN	_	_	_	_	_
3	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
4	interleukin	interleukin	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
5	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
6	4	4	NUM	CD	NumType=Card	_	_	_	_
7	receptor	receptor	NOUN	NN	Number=Sing	_	_	_	_
8	alpha	alpha	NOUN	NN	Number=Sing	_	_	_	_
9	chain	chain	NOUN	NN	Number=Sing	_	_	_	_
10	with	with	ADP	IN	_	_	_	_	_
11	p47phox	p47phox	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
12	,	,	PUNCT	,	_	_	_	_	_
13	an	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
14	activator	activator	NOUN	NN	Number=Sing	_	_	_	_
15	of	of	ADP	IN	_	_	_	_	_
16	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
17	phagocyte	phagocyte	ADJ	JJ	Degree=Pos	_	_	_	_
18	NADPH	NADPh	ADJ	JJ	Degree=Pos|NumType=Ord	_	_	_	_
19	oxidase	oxidase	NOUN	NN	Number=Sing	_	_	_	_
20	in	in	ADP	IN	_	_	_	_	_
21	B	b	ADJ	JJ	Degree=Pos	_	_	_	_
22	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
23	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 2962
# text = Interleukin (IL)-4 plays an important role in IgE synthesis in B cells and in Th2 differentiation in T cells.
1	Interleukin	Interleukin	PROPN	NNP	Number=Sing	_	_	_	_
2	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
3	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
4	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
5	-	-	SYM	SYM	_	_	_	_	SpaceAfter=No
6	4	4	NUM	CD	NumType=Card	_	_	_	_
7	plays	play	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
8	an	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
9	important	important	ADJ	JJ	Degree=Pos	_	_	_	_
10	role	role	NOUN	NN	Number=Sing	_	_	_	_
11	in	in	ADP	IN	_	_	_	_	_
12	IgE	Ige	PROPN	NNP	Number=Sing	_	_	_	_
13	synthesis	synthesis	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
14	in	in	ADP	IN	_	_	_	_	_
15	B	b	ADJ	JJ	Degree=Pos	_	_	_	_
16	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
17	and	and	CCONJ	CC	_	_	_	_	_
18	in	in	ADP	IN	_	_	_	_	_
19	Th2	Th2	NUM	CD	NumType=Card	_	_	_	_
20	differentiation	differentiation	NOUN	NN	Number=Sing	_	_	_	_
21	in	in	ADP	IN	_	_	_	_	_
22	T	t	PROPN	NNP	Number=Sing	_	_	_	_
23	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
24	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2963
# text = IL-4 conducts its biological activities through binding to the IL-4 receptor (IL-4R) on the surface of target cells.
1	IL	Il	INTJ	UH	_	_	_	_	SpaceAfter=No
2	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
3	4	4	NUM	CD	NumType=Card	_	_	_	_
4	conducts	conduct	NOUN	NNS	Number=Plur	_	_	_	_
5	its	its	PRON	PRP$	Gender=Neut|Number=Sing|Person=3|Poss=Yes|PronType=Prs	_	_	_	_
6	biological	biological	ADJ	JJ	Degree=Pos	_	_	_	_
7	activities	activity	NOUN	NNS	Number=Plur	_	_	_	_
8	through	through	SCONJ	IN	_	_	_	_	_
9	binding	bind	VERB	VBG	VerbForm=Ger	_	_	_	_
10	to	to	ADP	IN	_	_	_	_	_
11	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
12	IL	Il	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
13	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
14	4	4	NUM	CD	NumType=Card	_	_	_	_
15	receptor	receptor	NOUN	NN	Number=Sing	_	_	_	_
16	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
17	IL	Il	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
18	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
19	4R	4r	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
20	)	)	PUNCT	-RRB-	_	_	_	_	_
21	on	on	ADP	IN	_	_	_	_	_
22	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
23	surface	surface	NOUN	NN	Number=Sing	_	_	_	_
24	of	of	ADP	IN	_	_	_	_	_
25	target	target	NOUN	NN	Number=Sing	_	_	_	_
26	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
27	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2964
# text = IL-4R are thought to be composed of the IL-4R alpha chain (IL-4R alpha) and either the IL-2R gamma chain or the IL-13R alpha chain.
1	IL	Il	INTJ	UH	_	_	_	_	SpaceAfter=No
2	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
3	4R	4r	NOUN	NN	Number=Sing	_	_	_	_
4	are	be	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
5	thought	think	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
6	to	to	PART	TO	_	_	_	_	_
7	be	be	AUX	VB	VerbForm=Inf	_	_	_	_
8	composed	compose	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
9	of	of	ADP	IN	_	_	_	_	_
10	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
11	IL	Il	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
12	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
13	4R	4r	PROPN	NNP	Number=Sing	_	_	_	_
14	alpha	alpha	NOUN	NN	Number=Sing	_	_	_	_
15	chain	chain	NOUN	NN	Number=Sing	_	_	_	_
16	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
17	IL	Il	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
18	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
19	4R	4r	NOUN	NN	Number=Sing	_	_	_	_
20	alpha	alpha	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
21	)	)	PUNCT	-RRB-	_	_	_	_	_
22	and	and	CCONJ	CC	_	_	_	_	_
23	either	either	CCONJ	CC	_	_	_	_	_
24	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
25	IL	Il	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
26	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
27	2R	2r	NOUN	NN	Number=Sing	_	_	_	_
28	gamma	gamma	NOUN	NN	Number=Sing	_	_	_	_
29	chain	chain	NOUN	NN	Number=Sing	_	_	_	_
30	or	or	CCONJ	CC	_	_	_	_	_
31	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
32	IL	Il	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
33	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
34	13R	13r	PROPN	NNP	Number=Sing	_	_	_	_
35	alpha	alpha	NOUN	NN	Number=Sing	_	_	_	_
36	chain	chain	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
37	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2965
# text = We have previously shown that the membrane-proximal portion in the cytoplasmic domain of the human IL-4R alpha (hIL-4R alpha) is critical for proliferation, generation of germline epsilon transcript, and activation of STAT6, based on analyses of truncated hIL-4R alphas.
1	We	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
2	have	have	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
3	previously	previously	ADV	RB	_	_	_	_	_
4	shown	show	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
5	that	that	SCONJ	IN	_	_	_	_	_
6	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
7	membrane	membrane	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
8	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
9	proximal	proximal	ADJ	JJ	Degree=Pos	_	_	_	_
10	portion	portion	NOUN	NN	Number=Sing	_	_	_	_
11	in	in	ADP	IN	_	_	_	_	_
12	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
13	cytoplasmic	cytoplasmic	ADJ	JJ	Degree=Pos	_	_	_	_
14	domain	domain	NOUN	NN	Number=Sing	_	_	_	_
15	of	of	ADP	IN	_	_	_	_	_
16	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
17	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
18	IL	Il	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
19	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
20	4R	4r	PROPN	NNP	Number=Sing	_	_	_	_
21	alpha	alpha	NOUN	NN	Number=Sing	_	_	_	_
22	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
23	hIL	hil	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
24	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
25	4R	4r	NOUN	NN	Number=Sing	_	_	_	_
26	alpha	alpha	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
27	)	)	PUNCT	-RRB-	_	_	_	_	_
28	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
29	critical	critical	ADJ	JJ	Degree=Pos	_	_	_	_
30	for	for	ADP	IN	_	_	_	_	_
31	proliferation	proliferation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
32	,	,	PUNCT	,	_	_	_	_	_
33	generation	generation	NOUN	NN	Number=Sing	_	_	_	_
34	of	of	ADP	IN	_	_	_	_	_
35	germline	germline	NOUN	NN	Number=Sing	_	_	_	_
36	epsilon	epsilon	NOUN	NN	Number=Sing	_	_	_	_
37	transcript	transcript	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
38	,	,	PUNCT	,	_	_	_	_	_
39	and	and	CCONJ	CC	_	_	_	_	_
40	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
41	of	of	ADP	IN	_	_	_	_	_
42	STAT6	Stat6	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
43	,	,	PUNCT	,	_	_	_	_	_
44	based	base	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
45	on	on	ADP	IN	_	_	_	_	_
46	analyses	analysis	NOUN	NNS	Number=Plur	_	_	_	_
47	of	of	ADP	IN	_	_	_	_	_
48	truncated	truncated	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
49	hIL	hIL	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
50	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
51	4R	4R	NOUN	NN	Number=Sing	_	_	_	_
52	alphas	alpha	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
53	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2966
# text = In this study, we found that p47phox, an activator of the phagocyte NADPH oxidase, binds to this portion by the two-hybrid system.
1	In	in	ADP	IN	_	_	_	_	_
2	this	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
3	study	study	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
4	,	,	PUNCT	,	_	_	_	_	_
5	we	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
6	found	find	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
7	that	that	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
8	p47phox	p47phox	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
9	,	,	PUNCT	,	_	_	_	_	_
10	an	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
11	activator	activator	NOUN	NN	Number=Sing	_	_	_	_
12	of	of	ADP	IN	_	_	_	_	_
13	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
14	phagocyte	phagocyte	ADJ	JJ	Degree=Pos	_	_	_	_
15	NADPH	NADPH	PROPN	NNP	Number=Sing	_	_	_	_
16	oxidase	oxidase	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
17	,	,	PUNCT	,	_	_	_	_	_
18	binds	bind	NOUN	NNS	Number=Plur	_	_	_	_
19	to	to	ADP	IN	_	_	_	_	_
20	this	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
21	portion	portion	NOUN	NN	Number=Sing	_	_	_	_
22	by	by	ADP	IN	_	_	_	_	_
23	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
24	two	two	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
25	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
26	hybrid	hybrid	NOUN	NN	Number=Sing	_	_	_	_
27	system	system	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
28	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2967
# text = Furthermore, we observed the association of p47phox with the hIL-4R alpha in B cells derived from a normal donor.
1	Furthermore	furthermore	ADV	RB	_	_	_	_	SpaceAfter=No
2	,	,	PUNCT	,	_	_	_	_	_
3	we	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
4	observed	observe	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
5	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
6	association	association	NOUN	NN	Number=Sing	_	_	_	_
7	of	of	ADP	IN	_	_	_	_	_
8	p47phox	p47phox	NOUN	NN	Number=Sing	_	_	_	_
9	with	with	ADP	IN	_	_	_	_	_
10	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
11	hIL	hil	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
12	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
13	4R	4r	NOUN	NN	Number=Sing	_	_	_	_
14	alpha	alpha	NOUN	NN	Number=Sing	_	_	_	_
15	in	in	ADP	IN	_	_	_	_	_
16	B	b	ADJ	JJ	Degree=Pos	_	_	_	_
17	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
18	derived	derive	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
19	from	from	ADP	IN	_	_	_	_	_
20	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
21	normal	normal	ADJ	JJ	Degree=Pos	_	_	_	_
22	donor	donor	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
23	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2968
# text = These results suggest that p47phox is involved in the signal transduction of IL-4 in B cells.
1	These	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
2	results	result	NOUN	NNS	Number=Plur	_	_	_	_
3	suggest	suggest	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
4	that	that	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
5	p47phox	p47phox	NOUN	NN	Number=Sing	_	_	_	_
6	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
7	involved	involved	ADJ	JJ	Degree=Pos	_	_	_	_
8	in	in	ADP	IN	_	_	_	_	_
9	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
10	signal	signal	NOUN	NN	Number=Sing	_	_	_	_
11	transduction	transduction	NOUN	NN	Number=Sing	_	_	_	_
12	of	of	ADP	IN	_	_	_	_	_
13	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
14	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
15	4	4	NUM	CD	NumType=Card	_	_	_	_
16	in	in	ADP	IN	_	_	_	_	_
17	B	b	ADJ	JJ	Degree=Pos	_	_	_	_
18	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
19	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2969
# text = However, activation of STAT6, CD23 expression, and IgE synthesis induced by IL-4 were not affected in p47phox-deficient patients, which raises the possibility that p47phox may be important in other signaling activities as well in B cells.
1	However	however	ADV	RB	_	_	_	_	SpaceAfter=No
2	,	,	PUNCT	,	_	_	_	_	_
3	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
4	of	of	ADP	IN	_	_	_	_	_
5	STAT6	STAT6	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
6	,	,	PUNCT	,	_	_	_	_	_
7	CD23	CD23	NUM	CD	NumType=Card	_	_	_	_
8	expression	expression	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
9	,	,	PUNCT	,	_	_	_	_	_
10	and	and	CCONJ	CC	_	_	_	_	_
11	IgE	Ige	ADJ	JJ	Degree=Pos	_	_	_	_
12	synthesis	synthesis	NOUN	NN	Number=Sing	_	_	_	_
13	induced	induce	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
14	by	by	ADP	IN	_	_	_	_	_
15	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
16	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
17	4	4	NUM	CD	NumType=Card	_	_	_	_
18	were	be	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
19	not	not	PART	RB	_	_	_	_	_
20	affected	affect	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
21	in	in	ADP	IN	_	_	_	_	_
22	p47phox	p47phox	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
23	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
24	deficient	deficient	ADJ	JJ	Degree=Pos	_	_	_	_
25	patients	patient	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
26	,	,	PUNCT	,	_	_	_	_	_
27	which	which	PRON	WDT	PronType=Rel	_	_	_	_
28	raises	raise	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
29	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
30	possibility	possibility	NOUN	NN	Number=Sing	_	_	_	_
31	that	that	SCONJ	IN	_	_	_	_	_
32	p47phox	p47phox	NOUN	NN	Number=Sing	_	_	_	_
33	may	may	AUX	MD	VerbForm=Fin	_	_	_	_
34	be	be	AUX	VB	VerbForm=Inf	_	_	_	_
35	important	important	ADJ	JJ	Degree=Pos	_	_	_	_
36	in	in	ADP	IN	_	_	_	_	_
37	other	other	ADJ	JJ	Degree=Pos	_	_	_	_
38	signaling	signaling	NOUN	NN	Number=Sing	_	_	_	_
39	activities	activity	NOUN	NNS	Number=Plur	_	_	_	_
40	as	as	ADV	RB	_	_	_	_	_
41	well	well	ADV	RB	Degree=Pos	_	_	_	_
42	in	in	ADP	IN	_	_	_	_	_
43	B	b	ADJ	JJ	Degree=Pos	_	_	_	_
44	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
45	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 2970
# text = Document 003003355 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	003003355	003003355	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 2971
# text = PU.1 (Spi-1) and C/EBP alpha regulate expression of the granulocyte-macrophage colony-stimulating factor receptor alpha gene.
1	PU.1	PU.1	PROPN	NNP	Number=Sing	_	_	_	_
2	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
3	Spi	Spi	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
4	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
5	1	1	X	LS	_	_	_	_	SpaceAfter=No
6	)	)	PUNCT	-RRB-	_	_	_	_	_
7	and	and	CCONJ	CC	_	_	_	_	_
8	C	C	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
9	/	/	PUNCT	,	_	_	_	_	SpaceAfter=No
10	EBP	EBP	PROPN	NNP	Number=Sing	_	_	_	_
11	alpha	alpha	X	FW	Foreign=Yes	_	_	_	_
12	regulate	regulate	VERB	VB	VerbForm=Inf	_	_	_	_
13	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
14	of	of	ADP	IN	_	_	_	_	_
15	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
16	granulocyte	granulocyte	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
17	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
18	macrophage	macrophage	NOUN	NN	Number=Sing	_	_	_	_
19	colony	colony	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
20	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
21	stimulating	stimulate	VERB	VBG	VerbForm=Ger	_	_	_	_
22	factor	factor	NOUN	NN	Number=Sing	_	_	_	_
23	receptor	receptor	NOUN	NN	Number=Sing	_	_	_	_
24	alpha	alpha	ADP	IN	_	_	_	_	_
25	gene	gene	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
26	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 2972
# text = Growth factor receptors play an important role in hematopoiesis.
1	Growth	growth	ADJ	JJ	Degree=Pos|NumType=Ord	_	_	_	_
2	factor	factor	NOUN	NN	Number=Sing	_	_	_	_
3	receptors	receptor	NOUN	NNS	Number=Plur	_	_	_	_
4	play	play	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
5	an	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
6	important	important	ADJ	JJ	Degree=Pos	_	_	_	_
7	role	role	NOUN	NN	Number=Sing	_	_	_	_
8	in	in	ADP	IN	_	_	_	_	_
9	hematopoiesis	hematopoiesis	PRON	DT	Number=Sing|PronType=Dem	_	_	_	SpaceAfter=No
10	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2973
# text = In order to further understand the mechanisms directing the expression of these key regulators of hematopoiesis, we initiated a study investigating the transcription factors activating the expression of the granulocyte-macrophage colony-stimulating factor (GM-CSF) receptor alpha gene.
1	In	in	ADP	IN	_	_	_	_	_
2	order	order	NOUN	NN	Number=Sing	_	_	_	_
3	to	to	PART	TO	_	_	_	_	_
4	further	further	ADV	RB	_	_	_	_	_
5	understand	understand	VERB	VB	VerbForm=Inf	_	_	_	_
6	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
7	mechanisms	mechanism	NOUN	NNS	Number=Plur	_	_	_	_
8	directing	direct	VERB	VBG	VerbForm=Ger	_	_	_	_
9	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
10	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
11	of	of	ADP	IN	_	_	_	_	_
12	these	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
13	key	key	ADJ	JJ	Degree=Pos	_	_	_	_
14	regulators	regulator	NOUN	NNS	Number=Plur	_	_	_	_
15	of	of	ADP	IN	_	_	_	_	_
16	hematopoiesis	hematopoiesis	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
17	,	,	PUNCT	,	_	_	_	_	_
18	we	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
19	initiated	initiate	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
20	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
21	study	study	NOUN	NN	Number=Sing	_	_	_	_
22	investigating	investigate	VERB	VBG	VerbForm=Ger	_	_	_	_
23	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
24	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
25	factors	factor	NOUN	NNS	Number=Plur	_	_	_	_
26	activating	activate	VERB	VBG	VerbForm=Ger	_	_	_	_
27	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
28	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
29	of	of	ADP	IN	_	_	_	_	_
30	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
31	granulocyte	granulocyte	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
32	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
33	macrophage	macrophage	NOUN	NN	Number=Sing	_	_	_	_
34	colony	colony	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
35	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
36	stimulating	stimulating	VERB	VBG	VerbForm=Ger	_	_	_	_
37	factor	factor	NOUN	NN	Number=Sing	_	_	_	_
38	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
39	GM	GM	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
40	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
41	CSF	CSF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
42	)	)	PUNCT	-RRB-	_	_	_	_	_
43	receptor	receptor	NOUN	NN	Number=Sing	_	_	_	_
44	alpha	alpha	ADP	IN	_	_	_	_	_
45	gene	gene	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
46	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2974
# text = Here, we demonstrate that the human GM-CSF receptor alpha promoter directs reporter gene activity in a tissue-specific fashion in myelomonocytic cells, which correlates with its expression pattern as analyzed by reverse transcription PCR.
1	Here	here	ADV	RB	PronType=Dem	_	_	_	SpaceAfter=No
2	,	,	PUNCT	,	_	_	_	_	_
3	we	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
4	demonstrate	demonstrate	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
5	that	that	SCONJ	IN	_	_	_	_	_
6	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
7	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
8	GM	GM	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
9	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
10	CSF	CSF	PROPN	NNP	Number=Sing	_	_	_	_
11	receptor	receptor	NOUN	NN	Number=Sing	_	_	_	_
12	alpha	alpha	ADP	IN	_	_	_	_	_
13	promoter	promoter	NOUN	NN	Number=Sing	_	_	_	_
14	directs	direct	NOUN	NNS	Number=Plur	_	_	_	_
15	reporter	reporter	NOUN	NN	Number=Sing	_	_	_	_
16	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
17	activity	activity	NOUN	NN	Number=Sing	_	_	_	_
18	in	in	ADP	IN	_	_	_	_	_
19	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
20	tissue	tissue	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
21	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
22	specific	specific	ADJ	JJ	Degree=Pos	_	_	_	_
23	fashion	fashion	NOUN	NN	Number=Sing	_	_	_	_
24	in	in	ADP	IN	_	_	_	_	_
25	myelomonocytic	myelomonocytic	ADJ	JJ	Degree=Pos	_	_	_	_
26	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
27	,	,	PUNCT	,	_	_	_	_	_
28	which	which	PRON	WDT	PronType=Rel	_	_	_	_
29	correlates	correlate	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
30	with	with	ADP	IN	_	_	_	_	_
31	its	its	PRON	PRP$	Gender=Neut|Number=Sing|Person=3|Poss=Yes|PronType=Prs	_	_	_	_
32	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
33	pattern	pattern	ADJ	JJ	Degree=Pos	_	_	_	_
34	as	as	SCONJ	IN	_	_	_	_	_
35	analyzed	analyze	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
36	by	by	ADP	IN	_	_	_	_	_
37	reverse	reverse	NOUN	NN	Number=Sing	_	_	_	_
38	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
39	PCR	Pcr	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
40	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2975
# text = The GM-CSF receptor alpha promoter contains an important functional site between positions -53 and -41 as identified by deletion analysis of reporter constructs.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	GM	GM	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
3	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
4	CSF	CSF	PROPN	NNP	Number=Sing	_	_	_	_
5	receptor	receptor	NOUN	NN	Number=Sing	_	_	_	_
6	alpha	alpha	NOUN	NN	Number=Sing	_	_	_	_
7	promoter	promoter	NOUN	NN	Number=Sing	_	_	_	_
8	contains	contain	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
9	an	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
10	important	important	ADJ	JJ	Degree=Pos	_	_	_	_
11	functional	functional	ADJ	JJ	Degree=Pos	_	_	_	_
12	site	site	NOUN	NN	Number=Sing	_	_	_	_
13	between	between	ADP	IN	_	_	_	_	_
14	positions	position	NOUN	NNS	Number=Plur	_	_	_	_
15	-53	-53	NUM	CD	NumType=Card	_	_	_	_
16	and	and	CCONJ	CC	_	_	_	_	_
17	-	-	SYM	SYM	_	_	_	_	SpaceAfter=No
18	41	41	NUM	CD	NumType=Card	_	_	_	_
19	as	as	ADV	RB	_	_	_	_	_
20	identified	identify	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
21	by	by	ADP	IN	_	_	_	_	_
22	deletion	deletion	NOUN	NN	Number=Sing	_	_	_	_
23	analysis	analysis	NOUN	NN	Number=Sing	_	_	_	_
24	of	of	ADP	IN	_	_	_	_	_
25	reporter	reporter	NOUN	NN	Number=Sing	_	_	_	_
26	constructs	constructs	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
27	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2976
# text = We show that the myeloid and B cell transcription factor PU.1 binds specifically to this site.
1	We	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
2	show	show	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
3	that	that	SCONJ	IN	_	_	_	_	_
4	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
5	myeloid	myeloid	NOUN	NN	Number=Sing	_	_	_	_
6	and	and	CCONJ	CC	_	_	_	_	_
7	B	b	NOUN	NN	Number=Sing	_	_	_	_
8	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
9	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
10	factor	factor	NOUN	NN	Number=Sing	_	_	_	_
11	PU.1	PU.1	NUM	CD	NumType=Card	_	_	_	_
12	binds	bind	NOUN	NNS	Number=Plur	_	_	_	_
13	specifically	specifically	ADV	RB	_	_	_	_	_
14	to	to	ADP	IN	_	_	_	_	_
15	this	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
16	site	site	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
17	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2977
# text = Furthermore, we demonstrate that a CCAAT site located upstream of the PU.1 site between positions -70 and -54 is involved in positive-negative regulation of the GM-CSF receptor alpha promoter activity.
1	Furthermore	furthermore	ADV	RB	_	_	_	_	SpaceAfter=No
2	,	,	PUNCT	,	_	_	_	_	_
3	we	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
4	demonstrate	demonstrate	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
5	that	that	SCONJ	IN	_	_	_	_	_
6	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
7	CCAAT	Ccaat	ADJ	JJ	Degree=Pos	_	_	_	_
8	site	site	NOUN	NN	Number=Sing	_	_	_	_
9	located	locate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
10	upstream	upstream	NOUN	NN	Number=Sing	_	_	_	_
11	of	of	ADP	IN	_	_	_	_	_
12	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
13	PU.1	PU.1	PROPN	NNP	Number=Sing	_	_	_	_
14	site	site	NOUN	NN	Number=Sing	_	_	_	_
15	between	between	ADP	IN	_	_	_	_	_
16	positions	position	NOUN	NNS	Number=Plur	_	_	_	_
17	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
18	70	70	NUM	CD	NumType=Card	_	_	_	_
19	and	and	CCONJ	CC	_	_	_	_	_
20	-	-	SYM	SYM	_	_	_	_	SpaceAfter=No
21	54	54	NUM	CD	NumType=Card	_	_	_	_
22	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
23	involved	involved	ADJ	JJ	Degree=Pos	_	_	_	_
24	in	in	ADP	IN	_	_	_	_	_
25	positive	positive	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
26	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
27	negative	negative	ADJ	JJ	Degree=Pos	_	_	_	_
28	regulation	regulation	NOUN	NN	Number=Sing	_	_	_	_
29	of	of	ADP	IN	_	_	_	_	_
30	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
31	GM	GM	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
32	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
33	CSF	CSF	PROPN	NNP	Number=Sing	_	_	_	_
34	receptor	receptor	NOUN	NN	Number=Sing	_	_	_	_
35	alpha	alpha	ADP	IN	_	_	_	_	_
36	promoter	promoter	NOUN	NN	Number=Sing	_	_	_	_
37	activity	activity	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
38	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2978
# text = C/EBP alpha is the major CCAAT/enhancer-binding protein (C/EBP) form binding to this site in nuclear extracts of U937 cells.
1	C/	C/	SYM	NFP	_	_	_	_	SpaceAfter=No
2	EBP	EBP	PROPN	NNP	Number=Sing	_	_	_	_
3	alpha	alpha	PROPN	NNP	Number=Sing	_	_	_	_
4	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
5	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
6	major	major	ADJ	JJ	Degree=Pos	_	_	_	_
7	CCAAT	Ccaat	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
8	/	/	PUNCT	,	_	_	_	_	SpaceAfter=No
9	enhancer	enhancer	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
10	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
11	binding	binding	VERB	VBG	VerbForm=Ger	_	_	_	_
12	protein	protein	NOUN	NN	Number=Sing	_	_	_	_
13	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
14	C/	Cith	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
15	EBP	EBP	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
16	)	)	PUNCT	-RRB-	_	_	_	_	_
17	form	form	NOUN	NN	Number=Sing	_	_	_	_
18	binding	bind	VERB	VBG	VerbForm=Ger	_	_	_	_
19	to	to	ADP	IN	_	_	_	_	_
20	this	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
21	site	site	NOUN	NN	Number=Sing	_	_	_	_
22	in	in	ADP	IN	_	_	_	_	_
23	nuclear	nuclear	ADJ	JJ	Degree=Pos	_	_	_	_
24	extracts	extract	NOUN	NNS	Number=Plur	_	_	_	_
25	of	of	ADP	IN	_	_	_	_	_
26	U937	U937	NUM	CD	NumType=Card	_	_	_	_
27	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
28	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2979
# text = Point mutations of either the PU.1 site or the C/EBP site that abolish the binding of the respective factors result in a significant decrease of GM-CSF receptor alpha promoter activity in myelomonocytic cells only.
1	Point	point	ADJ	JJ	Degree=Pos	_	_	_	_
2	mutations	mutation	NOUN	NNS	Number=Plur	_	_	_	_
3	of	of	ADP	IN	_	_	_	_	_
4	either	either	CCONJ	CC	_	_	_	_	_
5	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
6	PU.1	Pu.1	NOUN	NN	Number=Sing	_	_	_	_
7	site	site	NOUN	NN	Number=Sing	_	_	_	_
8	or	or	CCONJ	CC	_	_	_	_	_
9	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
10	C/	c/	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
11	EBP	EBP	NOUN	NN	Number=Sing	_	_	_	_
12	site	site	NOUN	NN	Number=Sing	_	_	_	_
13	that	that	PRON	WDT	PronType=Rel	_	_	_	_
14	abolish	abolish	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
15	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
16	binding	binding	NOUN	NN	Number=Sing	_	_	_	_
17	of	of	ADP	IN	_	_	_	_	_
18	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
19	respective	respective	ADJ	JJ	Degree=Pos	_	_	_	_
20	factors	factor	NOUN	NNS	Number=Plur	_	_	_	_
21	result	result	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
22	in	in	ADP	IN	_	_	_	_	_
23	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
24	significant	significant	ADJ	JJ	Degree=Pos	_	_	_	_
25	decrease	decrease	NOUN	NN	Number=Sing	_	_	_	_
26	of	of	ADP	IN	_	_	_	_	_
27	GM	GM	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
28	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
29	CSF	CSF	PROPN	NNP	Number=Sing	_	_	_	_
30	receptor	receptor	NOUN	NN	Number=Sing	_	_	_	_
31	alpha	alpha	ADP	IN	_	_	_	_	_
32	promoter	promoter	NOUN	NN	Number=Sing	_	_	_	_
33	activity	activity	NOUN	NN	Number=Sing	_	_	_	_
34	in	in	ADP	IN	_	_	_	_	_
35	myelomonocytic	myelomonocytic	ADJ	JJ	Degree=Pos	_	_	_	_
36	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
37	only	only	ADV	RB	_	_	_	_	SpaceAfter=No
38	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2980
# text = Furthermore, we demonstrate that in myeloid and B cell extracts, PU.1 forms a novel, specific, more slowly migrating complex (PU-SF) when binding the GM-CSF receptor alpha promoter PU.1 site.
1	Furthermore	furthermore	ADV	RB	_	_	_	_	SpaceAfter=No
2	,	,	PUNCT	,	_	_	_	_	_
3	we	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
4	demonstrate	demonstrate	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
5	that	that	PRON	DT	Number=Sing|PronType=Dem	_	_	_	_
6	in	in	ADP	IN	_	_	_	_	_
7	myeloid	myeloid	ADJ	JJ	Degree=Pos	_	_	_	_
8	and	and	CCONJ	CC	_	_	_	_	_
9	B	b	ADJ	JJ	Degree=Pos	_	_	_	_
10	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
11	extracts	extract	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
12	,	,	PUNCT	,	_	_	_	_	_
13	PU.1	PU.1	NUM	CD	NumType=Card	_	_	_	_
14	forms	form	NOUN	NNS	Number=Plur	_	_	_	_
15	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
16	novel	novel	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
17	,	,	PUNCT	,	_	_	_	_	_
18	specific	specific	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
19	,	,	PUNCT	,	_	_	_	_	_
20	more	more	ADV	RBR	_	_	_	_	_
21	slowly	slowly	ADV	RB	_	_	_	_	_
22	migrating	migrating	VERB	VBG	VerbForm=Ger	_	_	_	_
23	complex	complex	NOUN	NN	Number=Sing	_	_	_	_
24	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
25	PU	PU	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
26	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
27	SF	SF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
28	)	)	PUNCT	-RRB-	_	_	_	_	_
29	when	when	ADV	WRB	PronType=Int	_	_	_	_
30	binding	bind	VERB	VBG	VerbForm=Ger	_	_	_	_
31	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
32	GM	GM	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
33	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
34	CSF	CSF	PROPN	NNP	Number=Sing	_	_	_	_
35	receptor	receptor	NOUN	NN	Number=Sing	_	_	_	_
36	alpha	alpha	NOUN	NN	Number=Sing	_	_	_	_
37	promoter	promoter	NOUN	NN	Number=Sing	_	_	_	_
38	PU.1	Pu.1	NUM	CD	NumType=Card	_	_	_	_
39	site	site	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
40	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2981
# text = This is the first demonstration of a specific interaction with PU.1 on a myeloid PU.1 binding site.
1	This	this	PRON	DT	Number=Sing|PronType=Dem	_	_	_	_
2	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
3	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
4	first	first	ADJ	JJ	Degree=Pos|NumType=Ord	_	_	_	_
5	demonstration	demonstration	NOUN	NN	Number=Sing	_	_	_	_
6	of	of	ADP	IN	_	_	_	_	_
7	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
8	specific	specific	ADJ	JJ	Degree=Pos	_	_	_	_
9	interaction	interaction	NOUN	NN	Number=Sing	_	_	_	_
10	with	with	ADP	IN	_	_	_	_	_
11	PU.1	PU.1	NUM	CD	NumType=Card	_	_	_	_
12	on	on	ADP	IN	_	_	_	_	_
13	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
14	myeloid	myeloid	ADJ	JJ	Degree=Pos	_	_	_	_
15	PU.1	Pu.1	NOUN	NN	Number=Sing	_	_	_	_
16	binding	binding	VERB	VBG	VerbForm=Ger	_	_	_	_
17	site	site	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
18	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2982
# text = The novel complex is distinct from that described previously as binding to B cell enhancer sites and can be formed by addition of PU.1 to extracts from certain nonmyeloid cell types which do not express PU.1, including T cells and epithelial cells, but not from erythroid cells.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	novel	novel	NOUN	NN	Number=Sing	_	_	_	_
3	complex	complex	NOUN	NN	Number=Sing	_	_	_	_
4	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
5	distinct	distinct	ADJ	JJ	Degree=Pos	_	_	_	_
6	from	from	ADP	IN	_	_	_	_	_
7	that	that	PRON	DT	Number=Sing|PronType=Dem	_	_	_	_
8	described	describe	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
9	previously	previously	ADV	RB	_	_	_	_	_
10	as	as	SCONJ	IN	_	_	_	_	_
11	binding	bind	VERB	VBG	VerbForm=Ger	_	_	_	_
12	to	to	ADP	IN	_	_	_	_	_
13	B	b	PROPN	NNP	Number=Sing	_	_	_	_
14	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
15	enhancer	enhancer	NOUN	NN	Number=Sing	_	_	_	_
16	sites	site	NOUN	NNS	Number=Plur	_	_	_	_
17	and	and	CCONJ	CC	_	_	_	_	_
18	can	can	AUX	MD	VerbForm=Fin	_	_	_	_
19	be	be	AUX	VB	VerbForm=Inf	_	_	_	_
20	formed	form	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
21	by	by	ADP	IN	_	_	_	_	_
22	addition	addition	NOUN	NN	Number=Sing	_	_	_	_
23	of	of	ADP	IN	_	_	_	_	_
24	PU.1	PU.1	NUM	CD	NumType=Card	_	_	_	_
25	to	to	ADP	IN	_	_	_	_	_
26	extracts	extract	NOUN	NNS	Number=Plur	_	_	_	_
27	from	from	ADP	IN	_	_	_	_	_
28	certain	certain	ADJ	JJ	Degree=Pos	_	_	_	_
29	nonmyeloid	nonmyeloid	ADJ	JJ	Degree=Pos	_	_	_	_
30	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
31	types	type	NOUN	NNS	Number=Plur	_	_	_	_
32	which	which	PRON	WDT	PronType=Rel	_	_	_	_
33	do	do	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
34	not	not	PART	RB	_	_	_	_	_
35	express	express	VERB	VB	VerbForm=Inf	_	_	_	_
36	PU.1	Pu.1	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
37	,	,	PUNCT	,	_	_	_	_	_
38	including	include	VERB	VBG	VerbForm=Ger	_	_	_	_
39	T	t	PROPN	NNP	Number=Sing	_	_	_	_
40	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
41	and	and	CCONJ	CC	_	_	_	_	_
42	epithelial	epithelial	ADJ	JJ	Degree=Pos	_	_	_	_
43	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
44	,	,	PUNCT	,	_	_	_	_	_
45	but	but	CCONJ	CC	_	_	_	_	_
46	not	not	ADV	RB	_	_	_	_	_
47	from	from	ADP	IN	_	_	_	_	_
48	erythroid	erythroid	ADJ	JJ	Degree=Pos	_	_	_	_
49	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
50	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2983
# text = Furthermore, we demonstrate that the PU-SF complex binds to PU.1 sites found on a number of myeloid promoters, and its formation requires an intact PU.1 site adjacent to a single-stranded region.
1	Furthermore	furthermore	ADV	RB	_	_	_	_	SpaceAfter=No
2	,	,	PUNCT	,	_	_	_	_	_
3	we	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
4	demonstrate	demonstrate	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
5	that	that	SCONJ	IN	_	_	_	_	_
6	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
7	PU	PU	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
8	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
9	SF	SF	PROPN	NNP	Number=Sing	_	_	_	_
10	complex	complex	ADJ	JJ	Degree=Pos	_	_	_	_
11	binds	bind	NOUN	NNS	Number=Plur	_	_	_	_
12	to	to	ADP	IN	_	_	_	_	_
13	PU.1	PU.1	PROPN	NNP	Number=Sing	_	_	_	_
14	sites	site	NOUN	NNS	Number=Plur	_	_	_	_
15	found	find	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
16	on	on	ADP	IN	_	_	_	_	_
17	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
18	number	number	NOUN	NN	Number=Sing	_	_	_	_
19	of	of	ADP	IN	_	_	_	_	_
20	myeloid	myeloid	ADJ	JJ	Degree=Pos	_	_	_	_
21	promoters	promoter	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
22	,	,	PUNCT	,	_	_	_	_	_
23	and	and	CCONJ	CC	_	_	_	_	_
24	its	its	PRON	PRP$	Gender=Neut|Number=Sing|Person=3|Poss=Yes|PronType=Prs	_	_	_	_
25	formation	formation	NOUN	NN	Number=Sing	_	_	_	_
26	requires	require	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
27	an	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
28	intact	intact	ADJ	JJ	Degree=Pos	_	_	_	_
29	PU.1	PU.1	NOUN	NN	Number=Sing	_	_	_	_
30	site	site	NOUN	NN	Number=Sing	_	_	_	_
31	adjacent	adjacent	NOUN	NN	Number=Sing	_	_	_	_
32	to	to	ADP	IN	_	_	_	_	_
33	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
34	single	single	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
35	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
36	stranded	strand	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
37	region	region	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
38	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2984
# text = Expression of PU.1 in nonmyeloid cells can activate the GM-CSF receptor alpha promoter.
1	Expression	expression	NOUN	NN	Number=Sing	_	_	_	_
2	of	of	ADP	IN	_	_	_	_	_
3	PU.1	Pu.1	NUM	CD	NumType=Card	_	_	_	_
4	in	in	ADP	IN	_	_	_	_	_
5	nonmyeloid	nonmyeloid	ADJ	JJ	Degree=Pos	_	_	_	_
6	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
7	can	can	AUX	MD	VerbForm=Fin	_	_	_	_
8	activate	activate	VERB	VB	VerbForm=Inf	_	_	_	_
9	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
10	GM	GM	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
11	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
12	CSF	CSF	PROPN	NNP	Number=Sing	_	_	_	_
13	receptor	receptor	NOUN	NN	Number=Sing	_	_	_	_
14	alpha	alpha	NOUN	NN	Number=Sing	_	_	_	_
15	promoter.	promoter.	NOUN	NN	Number=Sing	_	_	_	_

# sent_id = 2985
# text = Deletion of the amino-terminal region of PU.1 results in a failure to form the PU-SF complex and in a concomitant loss of transactivation, suggesting that formation of the PU-SF complex is of functional importance for the activity of the GM-CSF receptor alpha promoter.
1	Deletion	Deletion	NOUN	NN	Number=Sing	_	_	_	_
2	of	of	ADP	IN	_	_	_	_	_
3	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
4	amino	amino	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
5	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
6	terminal	terminal	NOUN	NN	Number=Sing	_	_	_	_
7	region	region	NOUN	NN	Number=Sing	_	_	_	_
8	of	of	ADP	IN	_	_	_	_	_
9	PU.1	PU.1	NUM	CD	NumType=Card	_	_	_	_
10	results	result	NOUN	NNS	Number=Plur	_	_	_	_
11	in	in	ADP	IN	_	_	_	_	_
12	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
13	failure	failure	NOUN	NN	Number=Sing	_	_	_	_
14	to	to	PART	TO	_	_	_	_	_
15	form	form	VERB	VB	VerbForm=Inf	_	_	_	_
16	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
17	PU	PU	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
18	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
19	SF	SF	PROPN	NNP	Number=Sing	_	_	_	_
20	complex	complex	NOUN	NN	Number=Sing	_	_	_	_
21	and	and	CCONJ	CC	_	_	_	_	_
22	in	in	ADP	IN	_	_	_	_	_
23	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
24	concomitant	concomitant	ADJ	JJ	Degree=Pos	_	_	_	_
25	loss	loss	NOUN	NN	Number=Sing	_	_	_	_
26	of	of	ADP	IN	_	_	_	_	_
27	transactivation	transactivation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
28	,	,	PUNCT	,	_	_	_	_	_
29	suggesting	suggest	VERB	VBG	VerbForm=Ger	_	_	_	_
30	that	that	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
31	formation	formation	NOUN	NN	Number=Sing	_	_	_	_
32	of	of	ADP	IN	_	_	_	_	_
33	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
34	PU	PU	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
35	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
36	SF	SF	PROPN	NNP	Number=Sing	_	_	_	_
37	complex	complex	NOUN	NN	Number=Sing	_	_	_	_
38	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
39	of	of	ADP	IN	_	_	_	_	_
40	functional	functional	ADJ	JJ	Degree=Pos	_	_	_	_
41	importance	importance	NOUN	NN	Number=Sing	_	_	_	_
42	for	for	ADP	IN	_	_	_	_	_
43	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
44	activity	activity	NOUN	NN	Number=Sing	_	_	_	_
45	of	of	ADP	IN	_	_	_	_	_
46	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
47	GM	GM	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
48	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
49	CSF	CSF	PROPN	NNP	Number=Sing	_	_	_	_
50	receptor	receptor	NOUN	NN	Number=Sing	_	_	_	_
51	alpha	alpha	ADP	IN	_	_	_	_	_
52	promoter	promoter	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
53	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2986
# text = Finally, we demonstrate that C/EBP alpha can also active the GM-CSF receptor alpha promoter in nonmyeloid cells.
1	Finally	finally	ADV	RB	_	_	_	_	SpaceAfter=No
2	,	,	PUNCT	,	_	_	_	_	_
3	we	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
4	demonstrate	demonstrate	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
5	that	that	SCONJ	IN	_	_	_	_	_
6	C	C	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
7	/	/	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
8	EBP	EBP	PROPN	NNP	Number=Sing	_	_	_	_
9	alpha	alpha	NOUN	NN	Number=Sing	_	_	_	_
10	can	can	AUX	MD	VerbForm=Fin	_	_	_	_
11	also	also	ADV	RB	_	_	_	_	_
12	active	active	VERB	VB	VerbForm=Inf	_	_	_	_
13	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
14	GM	GM	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
15	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
16	CSF	CSF	PROPN	NNP	Number=Sing	_	_	_	_
17	receptor	receptor	NOUN	NN	Number=Sing	_	_	_	_
18	alpha	alpha	NOUN	NN	Number=Sing	_	_	_	_
19	promoter	promoter	NOUN	NN	Number=Sing	_	_	_	_
20	in	in	ADP	IN	_	_	_	_	_
21	nonmyeloid	nonmyeloid	ADJ	JJ	Degree=Pos	_	_	_	_
22	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
23	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2987
# text = (ABSTRACT TRUNCATED AT 400 WORDS)
1	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
2	ABSTRACT	ABSTRACT	X	GW	_	_	_	_	_
3	TRUNCATED	Truncate	VERB	VB	Mood=Imp|VerbForm=Fin	_	_	_	_
4	AT	at	ADV	RB	_	_	_	_	_
5	400	400	NUM	CD	NumType=Card	_	_	_	_
6	WORDS	words	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
7	)	)	PUNCT	-RRB-	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 2988
# text = Document 003003358 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	003003358	003003358	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 2989
# text = The NF-kappa B inhibitor, tepoxalin, suppresses surface expression of the cell adhesion molecules CD62E, CD11b/CD18 and CD106.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	NF	Nf	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
3	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
4	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_
5	B	b	NOUN	NN	Number=Sing	_	_	_	_
6	inhibitor	inhibitor	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
7	,	,	PUNCT	,	_	_	_	_	_
8	tepoxalin	tepoxalin	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
9	,	,	PUNCT	,	_	_	_	_	_
10	suppresses	suppress	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
11	surface	surface	NOUN	NN	Number=Sing	_	_	_	_
12	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
13	of	of	ADP	IN	_	_	_	_	_
14	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
15	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
16	adhesion	adhesion	NOUN	NN	Number=Sing	_	_	_	_
17	molecules	molecule	NOUN	NNS	Number=Plur	_	_	_	_
18	CD62E	CD62E	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
19	,	,	PUNCT	,	_	_	_	_	_
20	CD11b/CD18	CD11b/CD18	PROPN	NNP	Number=Sing	_	_	_	_
21	and	and	CCONJ	CC	_	_	_	_	_
22	CD	CD	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
23	106	106	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
24	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 2990
# text = Tepoxalin, a dual enzyme inhibitor of cyclooxygenase and 5-lipoxygenase has been shown to inhibit T-cell activation.
1	Tepoxalin	Tepoxalin	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
2	,	,	PUNCT	,	_	_	_	_	_
3	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
4	dual	dual	ADJ	JJ	Degree=Pos	_	_	_	_
5	enzyme	enzyme	NOUN	NN	Number=Sing	_	_	_	_
6	inhibitor	inhibitor	NOUN	NN	Number=Sing	_	_	_	_
7	of	of	ADP	IN	_	_	_	_	_
8	cyclooxygenase	cyclooxygenase	NOUN	NN	Number=Sing	_	_	_	_
9	and	and	CCONJ	CC	_	_	_	_	_
10	5	5	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
11	-	-	PUNCT	:	_	_	_	_	SpaceAfter=No
12	lipoxygenase	lipoxygenase	NOUN	NN	Number=Sing	_	_	_	_
13	has	have	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
14	been	be	AUX	VBN	Tense=Past|VerbForm=Part	_	_	_	_
15	shown	show	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
16	to	to	PART	TO	_	_	_	_	_
17	inhibit	inhibit	VERB	VB	VerbForm=Inf	_	_	_	_
18	T-	t-	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
19	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
20	activation	activation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
21	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2991
# text = Its immunosuppressive property is distinct from cyclosporin because only tepoxalin, but not cyclosporin, suppresses NF-kappa B activation.
1	Its	its	PRON	PRP$	Gender=Neut|Number=Sing|Person=3|Poss=Yes|PronType=Prs	_	_	_	_
2	immunosuppressive	immunosuppressive	ADJ	JJ	Degree=Pos	_	_	_	_
3	property	property	NOUN	NN	Number=Sing	_	_	_	_
4	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
5	distinct	distinct	ADJ	JJ	Degree=Pos	_	_	_	_
6	from	from	ADP	IN	_	_	_	_	_
7	cyclosporin	cyclosporin	NOUN	NN	Number=Sing	_	_	_	_
8	because	because	SCONJ	IN	_	_	_	_	_
9	only	only	ADV	RB	_	_	_	_	_
10	tepoxalin	tepoxalin	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	SpaceAfter=No
11	,	,	PUNCT	,	_	_	_	_	_
12	but	but	CCONJ	CC	_	_	_	_	_
13	not	not	ADV	RB	_	_	_	_	_
14	cyclosporin	cyclosporin	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
15	,	,	PUNCT	,	_	_	_	_	_
16	suppresses	suppress	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
17	NF	Nf	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
18	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
19	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_
20	B	b	NOUN	NN	Number=Sing	_	_	_	_
21	activation	activation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
22	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2992
# text = Here we report that tepoxalin selectively inhibits intercellular adhesion molecule-1 (ICAM-1, CD54)/MAC-1 (CD11b/CD18) dependent adhesion of polymorphonuclear cells to IL-1 activated human umbilical vein endothelial cells.
1	Here	here	ADV	RB	PronType=Dem	_	_	_	_
2	we	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
3	report	report	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
4	that	that	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
5	tepoxalin	tepoxalin	NOUN	NN	Number=Sing	_	_	_	_
6	selectively	selectively	ADV	RB	_	_	_	_	_
7	inhibits	inhibit	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
8	intercellular	intercellular	ADJ	JJ	Degree=Pos	_	_	_	_
9	adhesion	adhesion	NOUN	NN	Number=Sing	_	_	_	_
10	molecule	molecule	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
11	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
12	1	1	NUM	CD	NumType=Card	_	_	_	_
13	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
14	ICAM	ICAm	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
15	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
16	1	1	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
17	,	,	PUNCT	,	_	_	_	_	_
18	CD54)	CD54)	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
19	/MAC	/mac	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
20	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
21	1	1	NUM	CD	NumType=Card	_	_	_	_
22	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
23	CD11b/CD18	CD11b/CD18	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
24	)	)	PUNCT	-RRB-	_	_	_	_	_
25	dependent	dependent	ADJ	JJ	Degree=Pos	_	_	_	_
26	adhesion	adhesion	NOUN	NN	Number=Sing	_	_	_	_
27	of	of	ADP	IN	_	_	_	_	_
28	polymorphonuclear	polymorphonuclear	ADJ	JJ	Degree=Pos	_	_	_	_
29	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
30	to	to	ADP	IN	_	_	_	_	_
31	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
32	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
33	1	1	NUM	CD	NumType=Card	_	_	_	_
34	activated	activate	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
35	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
36	umbilical	umbilical	ADJ	JJ	Degree=Pos	_	_	_	_
37	vein	vein	NOUN	NN	Number=Sing	_	_	_	_
38	endothelial	endothelial	ADJ	JJ	Degree=Pos	_	_	_	_
39	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
40	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2993
# text = The mechanism of inhibition is related to the surface expression of several cell adhesion molecules.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	mechanism	mechanism	NOUN	NN	Number=Sing	_	_	_	_
3	of	of	ADP	IN	_	_	_	_	_
4	inhibition	inhibition	NOUN	NN	Number=Sing	_	_	_	_
5	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
6	related	related	ADJ	JJ	Degree=Pos	_	_	_	_
7	to	to	ADP	IN	_	_	_	_	_
8	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
9	surface	surface	NOUN	NN	Number=Sing	_	_	_	_
10	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
11	of	of	ADP	IN	_	_	_	_	_
12	several	several	ADJ	JJ	Degree=Pos	_	_	_	_
13	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
14	adhesion	adhesion	NOUN	NN	Number=Sing	_	_	_	_
15	molecules	molecule	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
16	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2994
# text = Flow cytometry analyses on cultured cells that were treated with tepoxalin or antisense oligonucleotides to the P65/p50 subunit of NF-kappa B, and then stimulated with PMA, revealed a reduced expression of CD11b/CD18 on monocytic HL60 cells, and endothelial adhesion molecule-1 (CD62E) and vascular adhesion molecule-1 (CD106) on human umbilical vein endothelial cells.
1	Flow	flow	ADJ	JJ	Degree=Pos	_	_	_	_
2	cytometry	cytometry	NOUN	NN	Number=Sing	_	_	_	_
3	analyses	analysis	NOUN	NNS	Number=Plur	_	_	_	_
4	on	on	ADP	IN	_	_	_	_	_
5	cultured	culture	ADJ	JJ	Degree=Pos	_	_	_	_
6	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
7	that	that	PRON	WDT	PronType=Rel	_	_	_	_
8	were	be	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
9	treated	treat	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
10	with	with	ADP	IN	_	_	_	_	_
11	tepoxalin	tepoxalin	NOUN	NN	Number=Sing	_	_	_	_
12	or	or	CCONJ	CC	_	_	_	_	_
13	antisense	antisense	NOUN	NN	Number=Sing	_	_	_	_
14	oligonucleotides	oligonucleotide	NOUN	NNS	Number=Plur	_	_	_	_
15	to	to	ADP	IN	_	_	_	_	_
16	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
17	P65	P65	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
18	/	/	PUNCT	,	_	_	_	_	SpaceAfter=No
19	p50	p50	NUM	CD	NumType=Card	_	_	_	_
20	subunit	subunit	NOUN	NN	Number=Sing	_	_	_	_
21	of	of	ADP	IN	_	_	_	_	_
22	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
23	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
24	kappa	kappa	PROPN	NNP	Number=Sing	_	_	_	_
25	B	b	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
26	,	,	PUNCT	,	_	_	_	_	_
27	and	and	CCONJ	CC	_	_	_	_	_
28	then	then	ADV	RB	PronType=Dem	_	_	_	_
29	stimulated	stimulate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
30	with	with	ADP	IN	_	_	_	_	_
31	PMA	PMA	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
32	,	,	PUNCT	,	_	_	_	_	_
33	revealed	reveal	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
34	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
35	reduced	reduce	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
36	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
37	of	of	ADP	IN	_	_	_	_	_
38	CD11b/CD18	CD11b/CD18	NOUN	NN	Number=Sing	_	_	_	_
39	on	on	ADP	IN	_	_	_	_	_
40	monocytic	monocytic	ADJ	JJ	Degree=Pos	_	_	_	_
41	HL60	HL60	NUM	CD	NumType=Card	_	_	_	_
42	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
43	,	,	PUNCT	,	_	_	_	_	_
44	and	and	CCONJ	CC	_	_	_	_	_
45	endothelial	endothelial	ADJ	JJ	Degree=Pos	_	_	_	_
46	adhesion	adhesion	NOUN	NN	Number=Sing	_	_	_	_
47	molecule	molecule	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
48	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
49	1	1	NUM	CD	NumType=Card	_	_	_	_
50	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
51	CD62E	Cd62e	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
52	)	)	PUNCT	-RRB-	_	_	_	_	_
53	and	and	CCONJ	CC	_	_	_	_	_
54	vascular	vascular	ADJ	JJ	Degree=Pos	_	_	_	_
55	adhesion	adhesion	NOUN	NN	Number=Sing	_	_	_	_
56	molecule	molecule	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
57	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
58	1	1	NUM	CD	NumType=Card	_	_	_	_
59	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
60	CD106	CD106	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
61	)	)	PUNCT	-RRB-	_	_	_	_	_
62	on	on	ADP	IN	_	_	_	_	_
63	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
64	umbilical	umbilical	ADJ	JJ	Degree=Pos	_	_	_	_
65	vein	vein	NOUN	NN	Number=Sing	_	_	_	_
66	endothelial	endothelial	ADJ	JJ	Degree=Pos	_	_	_	_
67	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
68	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2995
# text = Expression of other adhesion molecules such as lymphocyte function associated-antigen-1 (CD11a/CD18) and CD54 were unaffected.
1	Expression	expression	NOUN	NN	Number=Sing	_	_	_	_
2	of	of	ADP	IN	_	_	_	_	_
3	other	other	ADJ	JJ	Degree=Pos	_	_	_	_
4	adhesion	adhesion	NOUN	NN	Number=Sing	_	_	_	_
5	molecules	molecule	NOUN	NNS	Number=Plur	_	_	_	_
6	such	such	ADJ	JJ	Degree=Pos	_	_	_	_
7	as	as	ADP	IN	_	_	_	_	_
8	lymphocyte	lymphocyte	ADJ	JJ	Degree=Pos	_	_	_	_
9	function	function	NOUN	NN	Number=Sing	_	_	_	_
10	associated	associate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	SpaceAfter=No
11	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
12	antigen	antigen	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
13	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
14	1	1	NUM	CD	NumType=Card	_	_	_	_
15	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
16	CD11a/CD18	CD11a/CD18	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
17	)	)	PUNCT	-RRB-	_	_	_	_	_
18	and	and	CCONJ	CC	_	_	_	_	_
19	CD54	CD54	PROPN	NNP	Number=Sing	_	_	_	_
20	were	be	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
21	unaffected	unaffected	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
22	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2996
# text = Tepoxalin also inhibited the secretion of a NF-kappa B regulated chemokine, IL-8, a known inducer of CD11b/CD18 expression.
1	Tepoxalin	Tepoxalin	PROPN	NNP	Number=Sing	_	_	_	_
2	also	also	ADV	RB	_	_	_	_	_
3	inhibited	inhibit	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
4	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
5	secretion	secretion	NOUN	NN	Number=Sing	_	_	_	_
6	of	of	ADP	IN	_	_	_	_	_
7	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
8	NF	NF	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
9	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
10	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_
11	B	b	NOUN	NN	Number=Sing	_	_	_	_
12	regulated	regulate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
13	chemokine	chemokine	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
14	,	,	PUNCT	,	_	_	_	_	_
15	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
16	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
17	8	8	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
18	,	,	PUNCT	,	_	_	_	_	_
19	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
20	known	know	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
21	inducer	inducer	NOUN	NN	Number=Sing	_	_	_	_
22	of	of	ADP	IN	_	_	_	_	_
23	CD11b/	Cd11b/	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
24	CD	cd	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
25	18	18	NUM	CD	NumType=Card	_	_	_	_
26	expression	expression	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
27	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2997
# text = Thus the suppression of CD11b/CD18 expression by tepoxalin may involve IL-8.
1	Thus	thus	ADV	RB	_	_	_	_	_
2	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
3	suppression	suppression	NOUN	NN	Number=Sing	_	_	_	_
4	of	of	ADP	IN	_	_	_	_	_
5	CD11b/	CD11b/	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
6	CD	CD	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
7	18	18	NUM	CD	NumType=Card	_	_	_	_
8	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
9	by	by	ADP	IN	_	_	_	_	_
10	tepoxalin	tepoxalin	NOUN	NN	Number=Sing	_	_	_	_
11	may	may	AUX	MD	VerbForm=Fin	_	_	_	_
12	involve	involve	VERB	VB	VerbForm=Inf	_	_	_	_
13	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
14	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
15	8	8	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
16	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 2998
# text = Our results suggest that by inhibiting NF-kappa B activation, surface expression of several adhesion molecules can be modulated and that tepoxalin may be useful in treating selected adhesion mediated events such as leukocyte migration or atherosclerotic plaque formation.
1	Our	we	PRON	PRP$	Number=Plur|Person=1|Poss=Yes|PronType=Prs	_	_	_	_
2	results	result	NOUN	NNS	Number=Plur	_	_	_	_
3	suggest	suggest	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
4	that	that	SCONJ	IN	_	_	_	_	_
5	by	by	SCONJ	IN	_	_	_	_	_
6	inhibiting	inhibit	VERB	VBG	VerbForm=Ger	_	_	_	_
7	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
8	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
9	kappa	kappa	PROPN	NNP	Number=Sing	_	_	_	_
10	B	b	PROPN	NNP	Number=Sing	_	_	_	_
11	activation	activation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
12	,	,	PUNCT	,	_	_	_	_	_
13	surface	surface	NOUN	NN	Number=Sing	_	_	_	_
14	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
15	of	of	ADP	IN	_	_	_	_	_
16	several	several	ADJ	JJ	Degree=Pos	_	_	_	_
17	adhesion	adhesion	NOUN	NN	Number=Sing	_	_	_	_
18	molecules	molecule	NOUN	NNS	Number=Plur	_	_	_	_
19	can	can	AUX	MD	VerbForm=Fin	_	_	_	_
20	be	be	AUX	VB	VerbForm=Inf	_	_	_	_
21	modulated	modulate	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
22	and	and	CCONJ	CC	_	_	_	_	_
23	that	that	SCONJ	IN	_	_	_	_	_
24	tepoxalin	tepoxalin	NOUN	NN	Number=Sing	_	_	_	_
25	may	may	AUX	MD	VerbForm=Fin	_	_	_	_
26	be	be	AUX	VB	VerbForm=Inf	_	_	_	_
27	useful	useful	ADJ	JJ	Degree=Pos	_	_	_	_
28	in	in	SCONJ	IN	_	_	_	_	_
29	treating	treat	VERB	VBG	VerbForm=Ger	_	_	_	_
30	selected	select	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
31	adhesion	adhesion	NOUN	NN	Number=Sing	_	_	_	_
32	mediated	mediate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
33	events	event	NOUN	NNS	Number=Plur	_	_	_	_
34	such	such	ADJ	JJ	Degree=Pos	_	_	_	_
35	as	as	ADP	IN	_	_	_	_	_
36	leukocyte	leukocyte	ADJ	JJ	Degree=Pos	_	_	_	_
37	migration	migration	NOUN	NN	Number=Sing	_	_	_	_
38	or	or	CCONJ	CC	_	_	_	_	_
39	atherosclerotic	atherosclerotic	ADJ	JJ	Degree=Pos	_	_	_	_
40	plaque	plaque	NOUN	NN	Number=Sing	_	_	_	_
41	formation	formation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
42	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 2999
# text = Document 003003360 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	003003360	003003360	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 3000
# text = Chronic human immunodeficiency virus type 1 infection of myeloid cells disrupts the autoregulatory control of the NF-kappaB/Rel pathway via enhanced IkappaBalpha degradation.
1	Chronic	Chronic	ADJ	JJ	Degree=Pos	_	_	_	_
2	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
3	immunodeficiency	immunodeficiency	NOUN	NN	Number=Sing	_	_	_	_
4	virus	virus	NOUN	NN	Number=Sing	_	_	_	_
5	type	type	NOUN	NN	Number=Sing	_	_	_	_
6	1	1	NUM	CD	NumType=Card	_	_	_	_
7	infection	infection	NOUN	NN	Number=Sing	_	_	_	_
8	of	of	ADP	IN	_	_	_	_	_
9	myeloid	myeloid	ADJ	JJ	Degree=Pos	_	_	_	_
10	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
11	disrupts	disrupt	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
12	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
13	autoregulatory	autoregulatory	ADJ	JJ	Degree=Pos	_	_	_	_
14	control	control	NOUN	NN	Number=Sing	_	_	_	_
15	of	of	ADP	IN	_	_	_	_	_
16	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
17	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
18	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
19	kappaB	kappaB	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
20	/	/	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
21	Rel	Rel	PROPN	NNP	Number=Sing	_	_	_	_
22	pathway	pathway	NOUN	NN	Number=Sing	_	_	_	_
23	via	via	ADP	IN	_	_	_	_	_
24	enhanced	enhance	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
25	IkappaBalpha	IkappaBalpha	PROPN	NNP	Number=Sing	_	_	_	_
26	degradation	degradation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
27	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 3001
# text = Productive human immunodeficiency virus type 1 (HIV-1) infection causes sustained NF-kappaB DNA-binding activity in chronically infected monocytic cells.
1	Productive	Productive	ADJ	JJ	Degree=Pos	_	_	_	_
2	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
3	immunodeficiency	immunodeficiency	NOUN	NN	Number=Sing	_	_	_	_
4	virus	virus	NOUN	NN	Number=Sing	_	_	_	_
5	type	type	NOUN	NN	Number=Sing	_	_	_	_
6	1	1	NUM	CD	NumType=Card	_	_	_	_
7	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
8	HIV	Hiv	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
9	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
10	1	1	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
11	)	)	PUNCT	-RRB-	_	_	_	_	_
12	infection	infection	NOUN	NN	Number=Sing	_	_	_	_
13	causes	cause	NOUN	NNS	Number=Plur	_	_	_	_
14	sustained	sustain	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
15	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
16	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
17	kappaB	kappaB	PROPN	NNP	Number=Sing	_	_	_	_
18	DNA	dna	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
19	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
20	binding	bind	VERB	VBG	VerbForm=Ger	_	_	_	_
21	activity	activity	NOUN	NN	Number=Sing	_	_	_	_
22	in	in	ADP	IN	_	_	_	_	_
23	chronically	chronically	ADV	RB	_	_	_	_	_
24	infected	infect	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
25	monocytic	monocytic	ADJ	JJ	Degree=Pos	_	_	_	_
26	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
27	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3002
# text = A direct temporal correlation exists between HIV infection and the appearance of NF-kappaB DNA-binding activity in myelomonoblastic PLB-985 cells.
1	A	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
2	direct	direct	ADJ	JJ	Degree=Pos	_	_	_	_
3	temporal	temporal	ADJ	JJ	Degree=Pos	_	_	_	_
4	correlation	correlation	NOUN	NN	Number=Sing	_	_	_	_
5	exists	exist	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
6	between	between	ADP	IN	_	_	_	_	_
7	HIV	Hiv	NOUN	NN	Number=Sing	_	_	_	_
8	infection	infection	NOUN	NN	Number=Sing	_	_	_	_
9	and	and	CCONJ	CC	_	_	_	_	_
10	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
11	appearance	appearance	NOUN	NN	Number=Sing	_	_	_	_
12	of	of	ADP	IN	_	_	_	_	_
13	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
14	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
15	kappaB	kappaB	PROPN	NNP	Number=Sing	_	_	_	_
16	DNA	dna	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
17	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
18	binding	bind	VERB	VBG	VerbForm=Ger	_	_	_	_
19	activity	activity	NOUN	NN	Number=Sing	_	_	_	_
20	in	in	ADP	IN	_	_	_	_	_
21	myelomonoblastic	myelomonoblastic	ADJ	JJ	Degree=Pos	_	_	_	_
22	PLB	PLB	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
23	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
24	985	985	NUM	CD	NumType=Card	_	_	_	_
25	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
26	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3003
# text = To examine the molecular basis of constitutive NF-kappaB DNA-binding activity in HIV1 -infected cells, we analyzed the phosphorylation and turnover of IkappaBalpha protein, the activity of the double-stranded RNA-dependent protein kinase (PKR) and the intracellular levels of NF-kappaB subunits in the PLB-985 and U937 myeloid cell models.
1	To	to	PART	TO	_	_	_	_	_
2	examine	examine	VERB	VB	VerbForm=Inf	_	_	_	_
3	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
4	molecular	molecular	ADJ	JJ	Degree=Pos	_	_	_	_
5	basis	basis	NOUN	NN	Number=Sing	_	_	_	_
6	of	of	ADP	IN	_	_	_	_	_
7	constitutive	constitutive	ADJ	JJ	Degree=Pos	_	_	_	_
8	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
9	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
10	kappaB	kappaB	PROPN	NNP	Number=Sing	_	_	_	_
11	DNA	dna	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
12	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
13	binding	binding	VERB	VBG	VerbForm=Ger	_	_	_	_
14	activity	activity	NOUN	NN	Number=Sing	_	_	_	_
15	in	in	ADP	IN	_	_	_	_	_
16	HIV1	HIV1	PROPN	NNP	Number=Sing	_	_	_	_
17	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
18	infected	infect	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
19	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
20	,	,	PUNCT	,	_	_	_	_	_
21	we	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
22	analyzed	analyze	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
23	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
24	phosphorylation	phosphorylation	NOUN	NN	Number=Sing	_	_	_	_
25	and	and	CCONJ	CC	_	_	_	_	_
26	turnover	turnover	NOUN	NN	Number=Sing	_	_	_	_
27	of	of	ADP	IN	_	_	_	_	_
28	IkappaBalpha	IkappaBalpha	PROPN	NNP	Number=Sing	_	_	_	_
29	protein	protein	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
30	,	,	PUNCT	,	_	_	_	_	_
31	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
32	activity	activity	NOUN	NN	Number=Sing	_	_	_	_
33	of	of	ADP	IN	_	_	_	_	_
34	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
35	double	double	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
36	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
37	stranded	strand	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
38	RNA	RNa	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
39	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
40	dependent	dependent	ADJ	JJ	Degree=Pos	_	_	_	_
41	protein	protein	NOUN	NN	Number=Sing	_	_	_	_
42	kinase	kinase	NOUN	NN	Number=Sing	_	_	_	_
43	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
44	PKR	PKR	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
45	)	)	PUNCT	-RRB-	_	_	_	_	_
46	and	and	CCONJ	CC	_	_	_	_	_
47	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
48	intracellular	intracellular	ADJ	JJ	Degree=Pos	_	_	_	_
49	levels	level	NOUN	NNS	Number=Plur	_	_	_	_
50	of	of	ADP	IN	_	_	_	_	_
51	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
52	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
53	kappaB	kappaB	PROPN	NNP	Number=Sing	_	_	_	_
54	subunits	subunit	NOUN	NNS	Number=Plur	_	_	_	_
55	in	in	ADP	IN	_	_	_	_	_
56	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
57	PLB	PLB	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
58	-985	-985	NUM	CD	NumType=Card	_	_	_	_
59	and	and	CCONJ	CC	_	_	_	_	_
60	U937	U937	NUM	CD	NumType=Card	_	_	_	_
61	myeloid	myeloid	ADJ	JJ	Degree=Pos	_	_	_	_
62	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
63	models	model	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
64	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3004
# text = HIV-1 infection resulted in constitutive, low-level expression of type 1 interferon (IFN) at the mRNA level.
1	HIV	Hiv	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
2	-	-	PUNCT	:	_	_	_	_	SpaceAfter=No
3	1	1	NUM	CD	NumType=Card	_	_	_	_
4	infection	infection	NOUN	NN	Number=Sing	_	_	_	_
5	resulted	result	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
6	in	in	ADP	IN	_	_	_	_	_
7	constitutive	constitutive	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
8	,	,	PUNCT	,	_	_	_	_	_
9	low	low	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
10	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
11	level	level	NOUN	NN	Number=Sing	_	_	_	_
12	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
13	of	of	ADP	IN	_	_	_	_	_
14	type	type	NOUN	NN	Number=Sing	_	_	_	_
15	1	1	NUM	CD	NumType=Card	_	_	_	_
16	interferon	interferon	NOUN	NN	Number=Sing	_	_	_	_
17	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
18	IFN	IFN	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
19	)	)	PUNCT	-RRB-	_	_	_	_	_
20	at	at	ADP	IN	_	_	_	_	_
21	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
22	mRNA	mRNA	PROPN	NNP	Number=Sing	_	_	_	_
23	level	level	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
24	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3005
# text = Constitutive PKR activity was also detected in HIV-1-infected cells as a result of low-level IFN production, since the addition of anti-IFN-alpha/beta antibody to the cells decreased PKR expression.
1	Constitutive	Constitutive	ADJ	JJ	Degree=Pos	_	_	_	_
2	PKR	Pkr	NOUN	NN	Number=Sing	_	_	_	_
3	activity	activity	NOUN	NN	Number=Sing	_	_	_	_
4	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
5	also	also	ADV	RB	_	_	_	_	_
6	detected	detect	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
7	in	in	ADP	IN	_	_	_	_	_
8	HIV	HIV	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
9	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
10	1	1	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
11	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
12	infected	infect	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
13	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
14	as	as	ADP	IN	_	_	_	_	_
15	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
16	result	result	NOUN	NN	Number=Sing	_	_	_	_
17	of	of	ADP	IN	_	_	_	_	_
18	low	low	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
19	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
20	level	level	NOUN	NN	Number=Sing	_	_	_	_
21	IFN	Ifn	NOUN	NN	Number=Sing	_	_	_	_
22	production	production	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
23	,	,	PUNCT	,	_	_	_	_	_
24	since	since	SCONJ	IN	_	_	_	_	_
25	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
26	addition	addition	NOUN	NN	Number=Sing	_	_	_	_
27	of	of	ADP	IN	_	_	_	_	_
28	anti-IFN-	anti-IFN-	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
29	alpha/	alpha/	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
30	beta	beof	NOUN	NN	Number=Sing	_	_	_	_
31	antibody	antibody	NOUN	NN	Number=Sing	_	_	_	_
32	to	to	ADP	IN	_	_	_	_	_
33	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
34	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
35	decreased	decrease	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
36	PKR	Pkr	ADP	IN	_	_	_	_	_
37	expression	expression	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
38	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3006
# text = Furthermore, the analysis of IkappaBalpha turnover demonstrated an increased degradation of IkappaBalpha in HIV-1-infected cells that may account for the constitutive DNA binding activity.
1	Furthermore	furthermore	ADV	RB	_	_	_	_	SpaceAfter=No
2	,	,	PUNCT	,	_	_	_	_	_
3	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
4	analysis	analysis	NOUN	NN	Number=Sing	_	_	_	_
5	of	of	ADP	IN	_	_	_	_	_
6	IkappaBalpha	IkappaBalpha	PROPN	NNP	Number=Sing	_	_	_	_
7	turnover	turnover	ADV	RB	_	_	_	_	_
8	demonstrated	demonstrate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
9	an	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
10	increased	increase	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
11	degradation	degradation	NOUN	NN	Number=Sing	_	_	_	_
12	of	of	ADP	IN	_	_	_	_	_
13	IkappaBalpha	IkappaBalpha	PROPN	NNP	Number=Sing	_	_	_	_
14	in	in	ADP	IN	_	_	_	_	_
15	HIV	HIV	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
16	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
17	1	1	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
18	-infected	-infected	ADJ	JJ	Degree=Pos	_	_	_	_
19	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
20	that	that	PRON	WDT	PronType=Rel	_	_	_	_
21	may	may	AUX	MD	VerbForm=Fin	_	_	_	_
22	account	account	VERB	VB	VerbForm=Inf	_	_	_	_
23	for	for	ADP	IN	_	_	_	_	_
24	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
25	constitutive	constitutive	ADJ	JJ	Degree=Pos	_	_	_	_
26	DNA	dna	NOUN	NN	Number=Sing	_	_	_	_
27	binding	bind	VERB	VBG	VerbForm=Ger	_	_	_	_
28	activity	activity	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
29	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3007
# text = A dramatic increase in the intracellular levels of NF-kappaB subunits c-Rel and NF-kappaB2 p100 and a moderate increase in NF-kappaB2 p52 and RelA(p65) were detected in HIV-1-infected cells, whereas NF-kappaB1 p105/p50 levels were not altered relative to the levels in uninfected cells.
1	A	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
2	dramatic	dramatic	ADJ	JJ	Degree=Pos	_	_	_	_
3	increase	increase	NOUN	NN	Number=Sing	_	_	_	_
4	in	in	ADP	IN	_	_	_	_	_
5	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
6	intracellular	intracellular	ADJ	JJ	Degree=Pos	_	_	_	_
7	levels	level	NOUN	NNS	Number=Plur	_	_	_	_
8	of	of	ADP	IN	_	_	_	_	_
9	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
10	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
11	kappaB	kappaB	PROPN	NNP	Number=Sing	_	_	_	_
12	subunits	subunit	NOUN	NNS	Number=Plur	_	_	_	_
13	c	class	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
14	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
15	Rel	Rel	NOUN	NN	Number=Sing	_	_	_	_
16	and	and	CCONJ	CC	_	_	_	_	_
17	NF	NF	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
18	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
19	kappaB2	kappab2	NOUN	NN	Number=Sing	_	_	_	_
20	p100	p100	NOUN	NN	Number=Sing	_	_	_	_
21	and	and	CCONJ	CC	_	_	_	_	_
22	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
23	moderate	moderate	ADJ	JJ	Degree=Pos	_	_	_	_
24	increase	increase	NOUN	NN	Number=Sing	_	_	_	_
25	in	in	ADP	IN	_	_	_	_	_
26	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
27	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
28	kappaB2	kappab2	NUM	CD	NumType=Card	_	_	_	_
29	p52	p52	NOUN	NN	Number=Sing	_	_	_	_
30	and	and	CCONJ	CC	_	_	_	_	_
31	RelA	Rela	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
32	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
33	p65	p65	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
34	)	)	PUNCT	-RRB-	_	_	_	_	_
35	were	be	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
36	detected	detect	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
37	in	in	ADP	IN	_	_	_	_	_
38	HIV	HIV	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
39	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
40	1	1	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
41	-infected	-infect	ADJ	JJ	Degree=Pos	_	_	_	_
42	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
43	,	,	PUNCT	,	_	_	_	_	_
44	whereas	whereas	SCONJ	IN	_	_	_	_	_
45	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
46	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
47	kappaB1	kappaB1	PROPN	NNP	Number=Sing	_	_	_	_
48	p105	p105	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
49	/	/	PUNCT	,	_	_	_	_	SpaceAfter=No
50	p50	p50	NUM	CD	NumType=Card	_	_	_	_
51	levels	level	NOUN	NNS	Number=Plur	_	_	_	_
52	were	be	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
53	not	not	PART	RB	_	_	_	_	_
54	altered	alter	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
55	relative	relative	ADV	RB	_	_	_	_	_
56	to	to	ADP	IN	_	_	_	_	_
57	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
58	levels	level	NOUN	NNS	Number=Plur	_	_	_	_
59	in	in	ADP	IN	_	_	_	_	_
60	uninfected	uninfected	ADJ	JJ	Degree=Pos	_	_	_	_
61	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
62	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3008
# text = We suggest that HIV-1 infection of myeloid cells induces IFN production and PKR activity, which in turn contribute to enhanced IkappaBalpha phosphorylation and subsequent degradation.
1	We	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
2	suggest	suggest	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
3	that	that	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
4	HIV	HIV	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
5	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
6	1	1	NUM	CD	NumType=Card	_	_	_	_
7	infection	infection	NOUN	NN	Number=Sing	_	_	_	_
8	of	of	ADP	IN	_	_	_	_	_
9	myeloid	myeloid	ADJ	JJ	Degree=Pos	_	_	_	_
10	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
11	induces	induces	NOUN	NNS	Number=Plur	_	_	_	_
12	IFN	Ifn	ADP	IN	_	_	_	_	_
13	production	production	NOUN	NN	Number=Sing	_	_	_	_
14	and	and	CCONJ	CC	_	_	_	_	_
15	PKR	Pkr	NOUN	NN	Number=Sing	_	_	_	_
16	activity	activity	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
17	,	,	PUNCT	,	_	_	_	_	_
18	which	which	PRON	WDT	PronType=Rel	_	_	_	_
19	in	in	ADP	IN	_	_	_	_	_
20	turn	turn	NOUN	NN	Number=Sing	_	_	_	_
21	contribute	contribute	NOUN	NN	Number=Sing	_	_	_	_
22	to	to	PART	TO	_	_	_	_	_
23	enhanced	enhance	VERB	VB	VerbForm=Inf	_	_	_	_
24	IkappaBalpha	IkappaBalpha	PROPN	NNP	Number=Sing	_	_	_	_
25	phosphorylation	phosphorylation	NOUN	NN	Number=Sing	_	_	_	_
26	and	and	CCONJ	CC	_	_	_	_	_
27	subsequent	subsequent	ADJ	JJ	Degree=Pos	_	_	_	_
28	degradation	degradation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
29	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3009
# text = Nuclear translocation of NF-kappaB subunits may ultimately increase the intracellular pool of NF-kappaB/IkappaBalpha by an autoregulatory mechanism.
1	Nuclear	nuclear	ADJ	JJ	Degree=Pos	_	_	_	_
2	translocation	translocation	NOUN	NN	Number=Sing	_	_	_	_
3	of	of	ADP	IN	_	_	_	_	_
4	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
5	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
6	kappaB	kappaB	PROPN	NNP	Number=Sing	_	_	_	_
7	subunits	subunit	NOUN	NNS	Number=Plur	_	_	_	_
8	may	may	AUX	MD	VerbForm=Fin	_	_	_	_
9	ultimately	ultimately	ADV	RB	_	_	_	_	_
10	increase	increase	VERB	VB	VerbForm=Inf	_	_	_	_
11	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
12	intracellular	intracellular	ADJ	JJ	Degree=Pos	_	_	_	_
13	pool	pool	NOUN	NN	Number=Sing	_	_	_	_
14	of	of	ADP	IN	_	_	_	_	_
15	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
16	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
17	kappaB	kappaB	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
18	/	/	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
19	IkappaBalpha	IkappaBalpha	PROPN	NNP	Number=Sing	_	_	_	_
20	by	by	ADP	IN	_	_	_	_	_
21	an	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
22	autoregulatory	autoregulatory	ADJ	JJ	Degree=Pos	_	_	_	_
23	mechanism	mechanism	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
24	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3010
# text = Enhanced turnover of IkappaBalpha and the accumulation of NF-kappaB/Rel proteins may contribute to the chronically activated state of HIV-1-infected cells.
1	Enhanced	enhance	ADJ	JJ	Degree=Pos	_	_	_	_
2	turnover	turnover	NOUN	NN	Number=Sing	_	_	_	_
3	of	of	ADP	IN	_	_	_	_	_
4	IkappaBalpha	IkappaBalpha	PROPN	NNP	Number=Sing	_	_	_	_
5	and	and	CCONJ	CC	_	_	_	_	_
6	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
7	accumulation	accumulation	NOUN	NN	Number=Sing	_	_	_	_
8	of	of	ADP	IN	_	_	_	_	_
9	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
10	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
11	kappaB	kappaB	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
12	/	/	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
13	Rel	Rel	PROPN	NNP	Number=Sing	_	_	_	_
14	proteins	protein	NOUN	NNS	Number=Plur	_	_	_	_
15	may	may	AUX	MD	VerbForm=Fin	_	_	_	_
16	contribute	contribute	VERB	VB	VerbForm=Inf	_	_	_	_
17	to	to	ADP	IN	_	_	_	_	_
18	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
19	chronically	chronically	ADV	RB	_	_	_	_	_
20	activated	activate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
21	state	state	NOUN	NN	Number=Sing	_	_	_	_
22	of	of	ADP	IN	_	_	_	_	_
23	HIV	HIV	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
24	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
25	1	1	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
26	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
27	infected	infect	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
28	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
29	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 3011
# text = Document 003003364 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	003003364	003003364	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 3012
# text = The role of gamma/delta T cell receptor positive cells in pregnancy.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	role	role	NOUN	NN	Number=Sing	_	_	_	_
3	of	of	ADP	IN	_	_	_	_	_
4	gamma	gamma	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
5	/	/	PUNCT	,	_	_	_	_	SpaceAfter=No
6	delta	delta	PROPN	NNP	Number=Sing	_	_	_	_
7	T	T	PROPN	NNP	Number=Sing	_	_	_	_
8	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
9	receptor	receptor	NOUN	NN	Number=Sing	_	_	_	_
10	positive	positive	ADJ	JJ	Degree=Pos	_	_	_	_
11	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
12	in	in	ADP	IN	_	_	_	_	_
13	pregnancy	pregnancy	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
14	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 3013
# text = PROBLEM: Due to the lack of classical HLA antigens on the trophoblast, fetal antigens are possibly presented in a non major histocompatibility complex (MHC) restricted way.
1	PROBLEM	problem	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
2	:	:	PUNCT	:	_	_	_	_	_
3	Due	due	ADP	IN	_	_	_	_	_
4	to	to	ADP	IN	_	_	_	_	_
5	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
6	lack	lack	NOUN	NN	Number=Sing	_	_	_	_
7	of	of	ADP	IN	_	_	_	_	_
8	classical	classical	ADJ	JJ	Degree=Pos	_	_	_	_
9	HLA	HLA	NOUN	NN	Number=Sing	_	_	_	_
10	antigens	antigen	NOUN	NNS	Number=Plur	_	_	_	_
11	on	on	ADP	IN	_	_	_	_	_
12	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
13	trophoblast	trophoblast	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
14	,	,	PUNCT	,	_	_	_	_	_
15	fetal	fetal	ADJ	JJ	Degree=Pos	_	_	_	_
16	antigens	antigen	NOUN	NNS	Number=Plur	_	_	_	_
17	are	be	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
18	possibly	possibly	ADV	RB	_	_	_	_	_
19	presented	present	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
20	in	in	ADP	IN	_	_	_	_	_
21	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
22	non	non	X	AFX	_	_	_	_	_
23	major	major	ADJ	JJ	Degree=Pos	_	_	_	_
24	histocompatibility	histocompatibility	NOUN	NN	Number=Sing	_	_	_	_
25	complex	complex	NOUN	NN	Number=Sing	_	_	_	_
26	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
27	MHC	MHC	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
28	)	)	PUNCT	-RRB-	_	_	_	_	_
29	restricted	restrict	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
30	way	way	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
31	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3014
# text = Decidual gammadelta
1	Decidual	Decidual	ADJ	JJ	Degree=Pos	_	_	_	_
2	gammadelta	gammadelta	NOUN	NN	Number=Sing	_	_	_	_

# sent_id = 3015
# text = T cells, which significantly increase in number during pregnancy, might play a role in recognition of fetal antigens and also in determining the quality of the response to these antigens.
1	T	t	PROPN	NNP	Number=Sing	_	_	_	_
2	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
3	,	,	PUNCT	,	_	_	_	_	_
4	which	which	PRON	WDT	PronType=Rel	_	_	_	_
5	significantly	significantly	ADV	RB	_	_	_	_	_
6	increase	increase	VERB	VB	VerbForm=Inf	_	_	_	_
7	in	in	ADP	RP	_	_	_	_	_
8	number	number	NOUN	NN	Number=Sing	_	_	_	_
9	during	during	ADP	IN	_	_	_	_	_
10	pregnancy	pregnancy	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
11	,	,	PUNCT	,	_	_	_	_	_
12	might	might	AUX	MD	VerbForm=Fin	_	_	_	_
13	play	play	VERB	VB	VerbForm=Inf	_	_	_	_
14	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
15	role	role	NOUN	NN	Number=Sing	_	_	_	_
16	in	in	ADP	IN	_	_	_	_	_
17	recognition	recognition	NOUN	NN	Number=Sing	_	_	_	_
18	of	of	ADP	IN	_	_	_	_	_
19	fetal	fetal	ADJ	JJ	Degree=Pos	_	_	_	_
20	antigens	antigen	NOUN	NNS	Number=Plur	_	_	_	_
21	and	and	CCONJ	CC	_	_	_	_	_
22	also	also	ADV	RB	_	_	_	_	_
23	in	in	SCONJ	IN	_	_	_	_	_
24	determining	determine	VERB	VBG	VerbForm=Ger	_	_	_	_
25	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
26	quality	quality	NOUN	NN	Number=Sing	_	_	_	_
27	of	of	ADP	IN	_	_	_	_	_
28	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
29	response	response	NOUN	NN	Number=Sing	_	_	_	_
30	to	to	ADP	IN	_	_	_	_	_
31	these	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
32	antigens	antigen	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
33	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3016
# text = Our study was aimed at investigating the role of this cell population in progesterone-dependent immunomodulation.
1	Our	we	PRON	PRP$	Number=Plur|Person=1|Poss=Yes|PronType=Prs	_	_	_	_
2	study	study	NOUN	NN	Number=Sing	_	_	_	_
3	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
4	aimed	aim	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
5	at	at	SCONJ	IN	_	_	_	_	_
6	investigating	investigate	VERB	VBG	VerbForm=Ger	_	_	_	_
7	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
8	role	role	NOUN	NN	Number=Sing	_	_	_	_
9	of	of	ADP	IN	_	_	_	_	_
10	this	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
11	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
12	population	population	NOUN	NN	Number=Sing	_	_	_	_
13	in	in	ADP	IN	_	_	_	_	_
14	progesterone	progesterone	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
15	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
16	dependent	dependent	ADJ	JJ	Degree=Pos	_	_	_	_
17	immunomodulation	immunomodulation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
18	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3017
# text = METHOD OF STUDY:
1	METHOD	method	NOUN	NN	Number=Sing	_	_	_	_
2	OF	of	ADP	IN	_	_	_	_	_
3	STUDY	study	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
4	:	:	PUNCT	:	_	_	_	_	_

# sent_id = 3018
# text = Peripheral lymphocytes from healthy pregnant women and from habitual aborters were tested by immunocytochemistry for the presence of gamma/delta T cell receptor (TCR) and progesterone receptor.
1	Peripheral	Peripheral	ADJ	JJ	Degree=Pos	_	_	_	_
2	lymphocytes	lymphocyte	NOUN	NNS	Number=Plur	_	_	_	_
3	from	from	ADP	IN	_	_	_	_	_
4	healthy	healthy	ADJ	JJ	Degree=Pos	_	_	_	_
5	pregnant	pregnant	ADJ	JJ	Degree=Pos	_	_	_	_
6	women	woman	NOUN	NNS	Number=Plur	_	_	_	_
7	and	and	CCONJ	CC	_	_	_	_	_
8	from	from	ADP	IN	_	_	_	_	_
9	habitual	habitual	ADJ	JJ	Degree=Pos	_	_	_	_
10	aborters	aborter	NOUN	NNS	Number=Plur	_	_	_	_
11	were	be	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
12	tested	test	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
13	by	by	ADP	IN	_	_	_	_	_
14	immunocytochemistry	immunocytochemistry	NOUN	NN	Number=Sing	_	_	_	_
15	for	for	ADP	IN	_	_	_	_	_
16	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
17	presence	presence	NOUN	NN	Number=Sing	_	_	_	_
18	of	of	ADP	IN	_	_	_	_	_
19	gamma/	gamma/	ADP	IN	Abbr=Yes	_	_	_	SpaceAfter=No
20	delta	delof	PROPN	NNP	Number=Sing	_	_	_	_
21	T	t	PROPN	NNP	Number=Sing	_	_	_	_
22	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
23	receptor	receptor	NOUN	NN	Number=Sing	_	_	_	_
24	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
25	TCR	TCR	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
26	)	)	PUNCT	-RRB-	_	_	_	_	_
27	and	and	CCONJ	CC	_	_	_	_	_
28	progesterone	progesterone	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
29	receptor	receptor	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
30	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3019
# text = To investigate the effect of treatment with a pan anti gamma/delta antibody, lymphocytes were incubated for 3 hr with the antibody, and then interleukin (IL)-10, IL-12 and progesterone-induced blocking factor (PIBF) expression (by immuno-cytochemistry) as well as natural killer (NK) cell activity were determined.
1	To	to	PART	TO	_	_	_	_	_
2	investigate	investigate	VERB	VB	VerbForm=Inf	_	_	_	_
3	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
4	effect	effect	NOUN	NN	Number=Sing	_	_	_	_
5	of	of	ADP	IN	_	_	_	_	_
6	treatment	treatment	NOUN	NN	Number=Sing	_	_	_	_
7	with	with	ADP	IN	_	_	_	_	_
8	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
9	pan	pan	NOUN	NN	Number=Sing	_	_	_	_
10	anti	anti	X	AFX	_	_	_	_	_
11	gamma	gamma	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
12	/	/	PUNCT	,	_	_	_	_	SpaceAfter=No
13	delta	delta	NOUN	NN	Number=Sing	_	_	_	_
14	antibody	antibody	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
15	,	,	PUNCT	,	_	_	_	_	_
16	lymphocytes	lymphocyte	NOUN	NNS	Number=Plur	_	_	_	_
17	were	be	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
18	incubated	incubate	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
19	for	for	ADP	IN	_	_	_	_	_
20	3	3	NUM	CD	NumType=Card	_	_	_	_
21	hr	hr	NOUN	NN	Number=Sing	_	_	_	_
22	with	with	ADP	IN	_	_	_	_	_
23	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
24	antibody	antibody	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
25	,	,	PUNCT	,	_	_	_	_	_
26	and	and	CCONJ	CC	_	_	_	_	_
27	then	then	ADV	RB	PronType=Dem	_	_	_	_
28	interleukin	interleukin	NOUN	NN	Number=Sing	_	_	_	_
29	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
30	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
31	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
32	-	-	SYM	SYM	_	_	_	_	SpaceAfter=No
33	10	10	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
34	,	,	PUNCT	,	_	_	_	_	_
35	IL	IL	ADV	RB	_	_	_	_	SpaceAfter=No
36	-	-	SYM	SYM	_	_	_	_	SpaceAfter=No
37	12	12	NUM	CD	NumType=Card	_	_	_	_
38	and	and	CCONJ	CC	_	_	_	_	_
39	progesterone	progesterone	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
40	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
41	induced	induce	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
42	blocking	blocking	NOUN	NN	Number=Sing	_	_	_	_
43	factor	factor	NOUN	NN	Number=Sing	_	_	_	_
44	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
45	PIBF	PIBF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
46	)	)	PUNCT	-RRB-	_	_	_	_	_
47	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
48	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
49	by	by	ADP	IN	_	_	_	_	_
50	immuno	immuno	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
51	-cytochemistry	-cytochemistry	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
52	)	)	PUNCT	-RRB-	_	_	_	_	_
53	as	as	ADV	RB	_	_	_	_	_
54	well	well	ADV	RB	Degree=Pos	_	_	_	_
55	as	as	ADP	IN	_	_	_	_	_
56	natural	natural	ADJ	JJ	Degree=Pos	_	_	_	_
57	killer	killer	NOUN	NN	Number=Sing	_	_	_	_
58	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
59	NK	NK	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
60	)	)	PUNCT	-RRB-	_	_	_	_	_
61	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
62	activity	activity	NOUN	NN	Number=Sing	_	_	_	_
63	were	be	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
64	determined	determine	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
65	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3020
# text = RESULTS: In peripheral blood of healthy pregnant women the percentage of gamma/delta TCR+ cells was significantly higher (P < 0.001) than in that of recurrent aborters or of non-pregnant individuals.
1	RESULTS	result	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
2	:	:	PUNCT	:	_	_	_	_	_
3	In	in	ADP	IN	_	_	_	_	_
4	peripheral	peripheral	ADJ	JJ	Degree=Pos	_	_	_	_
5	blood	blood	NOUN	NN	Number=Sing	_	_	_	_
6	of	of	ADP	IN	_	_	_	_	_
7	healthy	healthy	ADJ	JJ	Degree=Pos	_	_	_	_
8	pregnant	pregnant	ADJ	JJ	Degree=Pos	_	_	_	_
9	women	woman	NOUN	NNS	Number=Plur	_	_	_	_
10	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
11	percentage	percentage	NOUN	NN	Number=Sing	_	_	_	_
12	of	of	ADP	IN	_	_	_	_	_
13	gamma/	gammaith	ADP	IN	Abbr=Yes	_	_	_	SpaceAfter=No
14	delta	delta	PROPN	NNP	Number=Sing	_	_	_	_
15	TCR	TCR	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
16	+	+	SYM	SYM	_	_	_	_	_
17	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
18	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
19	significantly	significantly	ADV	RB	_	_	_	_	_
20	higher	higher	ADJ	JJR	Degree=Cmp	_	_	_	_
21	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
22	P	P	NOUN	NN	Number=Sing	_	_	_	_
23	<	<	PUNCT	-LRB-	_	_	_	_	_
24	0.001	0.001	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
25	)	)	PUNCT	-RRB-	_	_	_	_	_
26	than	than	ADP	IN	_	_	_	_	_
27	in	in	ADP	IN	_	_	_	_	_
28	that	that	PRON	DT	Number=Sing|PronType=Dem	_	_	_	_
29	of	of	ADP	IN	_	_	_	_	_
30	recurrent	recurrent	ADJ	JJ	Degree=Pos	_	_	_	_
31	aborters	aborter	NOUN	NNS	Number=Plur	_	_	_	_
32	or	or	CCONJ	CC	_	_	_	_	_
33	of	of	ADP	IN	_	_	_	_	_
34	non-pregnant	non-pregnant	ADJ	JJ	Degree=Pos	_	_	_	_
35	individuals	individual	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
36	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3021
# text = Ninety-seven percent of gamma/delta TCR+ pregnancy lymphocytes expressed progesterone receptor.
1	Ninety	Ninety	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
2	-	-	PUNCT	:	_	_	_	_	SpaceAfter=No
3	seven	seven	NUM	CD	NumType=Card	_	_	_	_
4	percent	percent	NOUN	NN	Number=Sing	_	_	_	_
5	of	of	ADP	IN	_	_	_	_	_
6	gamma/	gammaith	ADP	IN	Abbr=Yes	_	_	_	SpaceAfter=No
7	delta	delta	PROPN	NNP	Number=Sing	_	_	_	_
8	TCR	TCR	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
9	+	+	SYM	SYM	_	_	_	_	_
10	pregnancy	pregnancy	ADJ	JJ	Degree=Pos	_	_	_	_
11	lymphocytes	lymphocyte	NOUN	NNS	Number=Plur	_	_	_	_
12	expressed	express	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
13	progesterone	progesterone	ADJ	JJ	Degree=Pos	_	_	_	_
14	receptor	receptor	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
15	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3022
# text = Binding of a specific antibody to the gamma/delta TCR inhibited PIBF- as well as IL-10 production, whereas it increased NK activity and IL-12 expression.
1	Binding	binding	VERB	VBG	VerbForm=Ger	_	_	_	_
2	of	of	ADP	IN	_	_	_	_	_
3	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
4	specific	specific	ADJ	JJ	Degree=Pos	_	_	_	_
5	antibody	antibody	NOUN	NN	Number=Sing	_	_	_	_
6	to	to	ADP	IN	_	_	_	_	_
7	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
8	gamma/	gammaith	SYM	NFP	_	_	_	_	SpaceAfter=No
9	delta	delta	PROPN	NNP	Number=Sing	_	_	_	_
10	TCR	TCR	PROPN	NNP	Number=Sing	_	_	_	_
11	inhibited	inhibit	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
12	PIBF	PIBF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
13	-	-	PUNCT	,	_	_	_	_	_
14	as	as	ADV	RB	_	_	_	_	_
15	well	well	ADV	RB	Degree=Pos	_	_	_	_
16	as	as	ADP	IN	_	_	_	_	_
17	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
18	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
19	10	10	NUM	CD	NumType=Card	_	_	_	_
20	production	production	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
21	,	,	PUNCT	,	_	_	_	_	_
22	whereas	whereas	SCONJ	IN	_	_	_	_	_
23	it	it	PRON	PRP	Case=Nom|Gender=Neut|Number=Sing|Person=3|PronType=Prs	_	_	_	_
24	increased	increase	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
25	NK	NK	PROPN	NNP	Number=Sing	_	_	_	_
26	activity	activity	NOUN	NN	Number=Sing	_	_	_	_
27	and	and	CCONJ	CC	_	_	_	_	_
28	IL	Il	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
29	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
30	12	12	NUM	CD	NumType=Card	_	_	_	_
31	expression	expression	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
32	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3023
# text = CONCLUSIONS:
1	CONCLUSIONS	conclusion	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
2	:	:	PUNCT	:	_	_	_	_	_

# sent_id = 3024
# text = These data suggest the role of gamma/delta TCR-bearing lymphocytes in progesterone-dependent immunomodulation.
1	These	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
2	data	data	NOUN	NN	Number=Sing	_	_	_	_
3	suggest	suggest	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
4	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
5	role	role	NOUN	NN	Number=Sing	_	_	_	_
6	of	of	ADP	IN	_	_	_	_	_
7	gamma/	gammaith	ADP	IN	Abbr=Yes	_	_	_	SpaceAfter=No
8	delta	delta	PROPN	NNP	Number=Sing	_	_	_	_
9	TCR	Tcr	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
10	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
11	bearing	bearing	NOUN	NN	Number=Sing	_	_	_	_
12	lymphocytes	lymphocyte	NOUN	NNS	Number=Plur	_	_	_	_
13	in	in	ADP	IN	_	_	_	_	_
14	progesterone	progesterone	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
15	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
16	dependent	dependent	ADJ	JJ	Degree=Pos	_	_	_	_
17	immunomodulation	immunomodulation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
18	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 3025
# text = Document 003003368 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	003003368	003003368	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 3026
# text = The functional synergy between IL-12 and IL-2 involves p38 mitogen-activated protein kinase and is associated with the augmentation of STAT serine phosphorylation.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	functional	functional	ADJ	JJ	Degree=Pos	_	_	_	_
3	synergy	synergy	NOUN	NN	Number=Sing	_	_	_	_
4	between	between	ADP	IN	_	_	_	_	_
5	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
6	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
7	12	12	NUM	CD	NumType=Card	_	_	_	_
8	and	and	CCONJ	CC	_	_	_	_	_
9	IL	Il	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
10	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
11	2	2	NUM	CD	NumType=Card	_	_	_	_
12	involves	involf	NOUN	NNS	Number=Plur	_	_	_	_
13	p38	p38	NUM	CD	NumType=Card	_	_	_	_
14	mitogen	mitogen	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
15	-activated	-activated	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
16	protein	protein	NOUN	NN	Number=Sing	_	_	_	_
17	kinase	kinase	NOUN	NN	Number=Sing	_	_	_	_
18	and	and	CCONJ	CC	_	_	_	_	_
19	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
20	associated	associate	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
21	with	with	ADP	IN	_	_	_	_	_
22	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
23	augmentation	augmentation	NOUN	NN	Number=Sing	_	_	_	_
24	of	of	ADP	IN	_	_	_	_	_
25	STAT	Stat	NOUN	NN	Number=Sing	_	_	_	_
26	serine	serine	NOUN	NN	Number=Sing	_	_	_	_
27	phosphorylation	phosphorylation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
28	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 3027
# text = IL-12 and IL-2 can stimulate mitogen- or CD3-activated T cells to proliferate, produce IFN-gamma, and kill tumor cells.
1	IL	Il	INTJ	UH	_	_	_	_	SpaceAfter=No
2	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
3	12	12	NUM	CD	NumType=Card	_	_	_	_
4	and	and	CCONJ	CC	_	_	_	_	_
5	IL	Il	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
6	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
7	2	2	NUM	CD	NumType=Card	_	_	_	_
8	can	can	AUX	MD	VerbForm=Fin	_	_	_	_
9	stimulate	stimulate	VERB	VB	VerbForm=Inf	_	_	_	_
10	mitogen	mitogen	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
11	-	-	PUNCT	,	_	_	_	_	_
12	or	or	CCONJ	CC	_	_	_	_	_
13	CD3	CD3	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
14	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
15	activated	activate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
16	T	t	PROPN	NNP	Number=Sing	_	_	_	_
17	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
18	to	to	PART	TO	_	_	_	_	_
19	proliferate	proliferate	VERB	VB	VerbForm=Inf	_	_	_	SpaceAfter=No
20	,	,	PUNCT	,	_	_	_	_	_
21	produce	produce	VERB	VB	VerbForm=Inf	_	_	_	_
22	IFN	Ifn	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
23	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
24	gamma	gamma	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
25	,	,	PUNCT	,	_	_	_	_	_
26	and	and	CCONJ	CC	_	_	_	_	_
27	kill	kill	VERB	VB	VerbForm=Inf	_	_	_	_
28	tumor	tumor	NOUN	NN	Number=Sing	_	_	_	_
29	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
30	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3028
# text = The magnitude of these functional responses is greatly augmented when T cells are activated by the combination of IL-12 and IL-2.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	magnitude	magnitude	NOUN	NN	Number=Sing	_	_	_	_
3	of	of	ADP	IN	_	_	_	_	_
4	these	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
5	functional	functional	ADJ	JJ	Degree=Pos	_	_	_	_
6	responses	response	NOUN	NNS	Number=Plur	_	_	_	_
7	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
8	greatly	greatly	ADV	RB	_	_	_	_	_
9	augmented	augment	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
10	when	when	ADV	WRB	PronType=Int	_	_	_	_
11	T	t	NUM	CD	NumType=Card	_	_	_	_
12	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
13	are	be	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
14	activated	activate	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
15	by	by	ADP	IN	_	_	_	_	_
16	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
17	combination	combination	NOUN	NN	Number=Sing	_	_	_	_
18	of	of	ADP	IN	_	_	_	_	_
19	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
20	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
21	12	12	NUM	CD	NumType=Card	_	_	_	_
22	and	and	CCONJ	CC	_	_	_	_	_
23	IL	il	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
24	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
25	2	2	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
26	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3029
# text = Although peripheral blood T cells are largely unresponsive to these cytokines without prior activation, a small subset of CD8+ T cells (CD8+CD18bright) is strongly activated by the combination of IL-12 and IL-2.
1	Although	although	SCONJ	IN	_	_	_	_	_
2	peripheral	peripheral	ADJ	JJ	Degree=Pos	_	_	_	_
3	blood	blood	NOUN	NN	Number=Sing	_	_	_	_
4	T	t	NOUN	NN	Number=Sing	_	_	_	_
5	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
6	are	be	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
7	largely	largely	ADV	RB	_	_	_	_	_
8	unresponsive	unresponsive	ADJ	JJ	Degree=Pos	_	_	_	_
9	to	to	ADP	IN	_	_	_	_	_
10	these	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
11	cytokines	cytokine	NOUN	NNS	Number=Plur	_	_	_	_
12	without	without	ADP	IN	_	_	_	_	_
13	prior	prior	ADJ	JJ	Degree=Pos	_	_	_	_
14	activation	activation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
15	,	,	PUNCT	,	_	_	_	_	_
16	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
17	small	small	ADJ	JJ	Degree=Pos	_	_	_	_
18	subset	subset	NOUN	NN	Number=Sing	_	_	_	_
19	of	of	ADP	IN	_	_	_	_	_
20	CD8	CD8	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
21	+	+	SYM	SYM	_	_	_	_	_
22	T	t	NUM	CD	NumType=Card	_	_	_	_
23	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
24	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
25	CD8+CD18bright	CD8+CD18bright	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
26	)	)	PUNCT	-RRB-	_	_	_	_	_
27	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
28	strongly	strongly	ADV	RB	_	_	_	_	_
29	activated	activate	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
30	by	by	ADP	IN	_	_	_	_	_
31	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
32	combination	combination	NOUN	NN	Number=Sing	_	_	_	_
33	of	of	ADP	IN	_	_	_	_	_
34	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
35	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
36	12	12	NUM	CD	NumType=Card	_	_	_	_
37	and	and	CCONJ	CC	_	_	_	_	_
38	IL	il	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
39	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
40	2	2	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
41	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3030
# text = In this report we show that the functional synergy between IL-12 and IL-2 in CD8+CD18bright T cells correlates with the activation of the stress kinases, p38 mitogen-activated protein (MAP) kinase and stress-activated protein kinase (SAPK)/Jun N-terminal kinase, but not with the activation of the extracellular signal-regulated kinases.
1	In	in	ADP	IN	_	_	_	_	_
2	this	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
3	report	report	NOUN	NN	Number=Sing	_	_	_	_
4	we	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
5	show	show	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
6	that	that	SCONJ	IN	_	_	_	_	_
7	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
8	functional	functional	ADJ	JJ	Degree=Pos	_	_	_	_
9	synergy	synergy	NOUN	NN	Number=Sing	_	_	_	_
10	between	between	ADP	IN	_	_	_	_	_
11	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
12	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
13	12	12	NUM	CD	NumType=Card	_	_	_	_
14	and	and	CCONJ	CC	_	_	_	_	_
15	IL	Il	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
16	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
17	2	2	NUM	CD	NumType=Card	_	_	_	_
18	in	in	ADP	IN	_	_	_	_	_
19	CD8+CD	Cd8+cd	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
20	18bright	18bright	AUX	MD	VerbForm=Fin	_	_	_	_
21	T	t	PROPN	NNP	Number=Sing	_	_	_	_
22	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
23	correlates	correlate	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
24	with	with	ADP	IN	_	_	_	_	_
25	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
26	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
27	of	of	ADP	IN	_	_	_	_	_
28	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
29	stress	stress	NOUN	NN	Number=Sing	_	_	_	_
30	kinases	kinase	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
31	,	,	PUNCT	,	_	_	_	_	_
32	p38	p38	NUM	CD	NumType=Card	_	_	_	_
33	mitogen	mitogen	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
34	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
35	activated	activate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
36	protein	protein	NOUN	NN	Number=Sing	_	_	_	_
37	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
38	MAP	map	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
39	)	)	PUNCT	-RRB-	_	_	_	_	_
40	kinase	kinase	NOUN	NN	Number=Sing	_	_	_	_
41	and	and	CCONJ	CC	_	_	_	_	_
42	stress	stress	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
43	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
44	activated	activate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
45	protein	protein	NOUN	NN	Number=Sing	_	_	_	_
46	kinase	kinase	NOUN	NN	Number=Sing	_	_	_	_
47	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
48	SAPK	SAPK	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
49	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
50	/	/	PUNCT	,	_	_	_	_	SpaceAfter=No
51	Jun	Jun	PROPN	NNP	Number=Sing	_	_	_	_
52	N-	N-	SYM	NFP	_	_	_	_	SpaceAfter=No
53	terminal	terminal	ADJ	JJ	Degree=Pos	_	_	_	_
54	kinase	kinase	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
55	,	,	PUNCT	,	_	_	_	_	_
56	but	but	CCONJ	CC	_	_	_	_	_
57	not	not	ADV	RB	_	_	_	_	_
58	with	with	ADP	IN	_	_	_	_	_
59	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
60	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
61	of	of	ADP	IN	_	_	_	_	_
62	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
63	extracellular	extracellular	ADJ	JJ	Degree=Pos	_	_	_	_
64	signal	signal	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
65	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
66	regulated	regulate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
67	kinases	kinase	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
68	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3031
# text = The functional synergy between IL-2 and IL-12 is also associated with a prominent increase in STAT1 and STAT3 serine phosphorylation over that observed with IL-12 or IL-2 alone.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	functional	functional	ADJ	JJ	Degree=Pos	_	_	_	_
3	synergy	synergy	NOUN	NN	Number=Sing	_	_	_	_
4	between	between	ADP	IN	_	_	_	_	_
5	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
6	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
7	2	2	NUM	CD	NumType=Card	_	_	_	_
8	and	and	CCONJ	CC	_	_	_	_	_
9	IL	Il	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
10	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
11	12	12	NUM	CD	NumType=Card	_	_	_	_
12	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
13	also	also	ADV	RB	_	_	_	_	_
14	associated	associate	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
15	with	with	ADP	IN	_	_	_	_	_
16	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
17	prominent	prominent	ADJ	JJ	Degree=Pos	_	_	_	_
18	increase	increase	NOUN	NN	Number=Sing	_	_	_	_
19	in	in	ADP	IN	_	_	_	_	_
20	STAT1	STAT1	NUM	CD	NumType=Card	_	_	_	_
21	and	and	CCONJ	CC	_	_	_	_	_
22	STAT3	STAT3	NUM	CD	NumType=Card	_	_	_	_
23	serine	serine	NOUN	NN	Number=Sing	_	_	_	_
24	phosphorylation	phosphorylation	NOUN	NN	Number=Sing	_	_	_	_
25	over	over	ADP	IN	_	_	_	_	_
26	that	that	PRON	DT	Number=Sing|PronType=Dem	_	_	_	_
27	observed	observe	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
28	with	with	ADP	IN	_	_	_	_	_
29	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
30	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
31	12	12	NUM	CD	NumType=Card	_	_	_	_
32	or	or	CCONJ	CC	_	_	_	_	_
33	IL	il	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
34	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
35	2	2	NUM	CD	NumType=Card	_	_	_	_
36	alone	alone	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
37	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3032
# text = By contrast, STAT tyrosine phosphorylation is not augmented over that seen with either cytokine alone.
1	By	by	ADP	IN	_	_	_	_	_
2	contrast	contrast	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
3	,	,	PUNCT	,	_	_	_	_	_
4	STAT	Stat	NOUN	NN	Number=Sing	_	_	_	_
5	tyrosine	tyrosine	NOUN	NN	Number=Sing	_	_	_	_
6	phosphorylation	phosphorylation	NOUN	NN	Number=Sing	_	_	_	_
7	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
8	not	not	PART	RB	_	_	_	_	_
9	augmented	augment	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
10	over	over	ADP	IN	_	_	_	_	_
11	that	that	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
12	seen	see	NOUN	NN	Number=Sing	_	_	_	_
13	with	with	ADP	IN	_	_	_	_	_
14	either	either	DET	DT	_	_	_	_	_
15	cytokine	cytokine	NOUN	NN	Number=Sing	_	_	_	_
16	alone	alone	ADV	RB	_	_	_	_	SpaceAfter=No
17	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3033
# text = A specific inhibitor of p38 MAP kinase completely inhibits the serine phosphorylation of STAT1 and STAT3 induced by IL-12 and IL-2 and abrogates the functional synergy between IL-12 and IL-2 without affecting
1	A	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
2	specific	specific	ADJ	JJ	Degree=Pos	_	_	_	_
3	inhibitor	inhibitor	NOUN	NN	Number=Sing	_	_	_	_
4	of	of	ADP	IN	_	_	_	_	_
5	p38	p38	NUM	CD	NumType=Card	_	_	_	_
6	MAP	map	NOUN	NN	Number=Sing	_	_	_	_
7	kinase	kinase	NOUN	NN	Number=Sing	_	_	_	_
8	completely	completely	ADV	RB	_	_	_	_	_
9	inhibits	inhibit	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
10	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
11	serine	serine	NOUN	NN	Number=Sing	_	_	_	_
12	phosphorylation	phosphorylation	NOUN	NN	Number=Sing	_	_	_	_
13	of	of	ADP	IN	_	_	_	_	_
14	STAT1	STAT1	NOUN	NN	Number=Sing	_	_	_	_
15	and	and	CCONJ	CC	_	_	_	_	_
16	STAT3	STAT3	NOUN	NN	Number=Sing	_	_	_	_
17	induced	induce	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
18	by	by	ADP	IN	_	_	_	_	_
19	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
20	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
21	12	12	NUM	CD	NumType=Card	_	_	_	_
22	and	and	CCONJ	CC	_	_	_	_	_
23	IL	Il	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
24	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
25	2	2	NUM	CD	NumType=Card	_	_	_	_
26	and	and	CCONJ	CC	_	_	_	_	_
27	abrogates	abrogate	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
28	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
29	functional	functional	ADJ	JJ	Degree=Pos	_	_	_	_
30	synergy	synergy	NOUN	NN	Number=Sing	_	_	_	_
31	between	between	ADP	IN	_	_	_	_	_
32	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
33	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
34	12	12	NUM	CD	NumType=Card	_	_	_	_
35	and	and	CCONJ	CC	_	_	_	_	_
36	IL	Il	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
37	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
38	2	2	NUM	CD	NumType=Card	_	_	_	_
39	without	without	SCONJ	IN	_	_	_	_	_
40	affecting	affect	VERB	VBG	VerbForm=Ger	_	_	_	_

# sent_id = 3034
# text = STAT tyrosine phosphorylation.
1	STAT	Stat	VERB	VB	Mood=Imp|VerbForm=Fin	_	_	_	_
2	tyrosine	tyrosine	PRON	PRP	_	_	_	_	_
3	phosphorylation	phosphorylation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3035
# text = This suggests that p38 MAP kinase may play an important role in regulating
1	This	this	PRON	DT	Number=Sing|PronType=Dem	_	_	_	_
2	suggests	suggest	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
3	that	that	SCONJ	IN	_	_	_	_	_
4	p38	p38	NUM	CD	NumType=Card	_	_	_	_
5	MAP	map	NOUN	NN	Number=Sing	_	_	_	_
6	kinase	kinase	NOUN	NN	Number=Sing	_	_	_	_
7	may	may	AUX	MD	VerbForm=Fin	_	_	_	_
8	play	play	VERB	VB	VerbForm=Inf	_	_	_	_
9	an	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
10	important	important	ADJ	JJ	Degree=Pos	_	_	_	_
11	role	role	NOUN	NN	Number=Sing	_	_	_	_
12	in	in	SCONJ	IN	_	_	_	_	_
13	regulating	regulat	VERB	VBG	VerbForm=Ger	_	_	_	_

# sent_id = 3036
# text = STAT serine phosphorylation in response to the combination of IL-12 and IL-2. Furthermore, these findings indicate that the optimal activation of T cells by IL-12 and IL-2 may depend on an interaction between the p38 MAP kinase and Janus kinase/STAT signaling pathways.
1	STAT	Stat	VERB	VB	Mood=Imp|VerbForm=Fin	_	_	_	_
2	serine	serine	PRON	PRP	_	_	_	_	_
3	phosphorylation	phosphorylation	NOUN	NN	Number=Sing	_	_	_	_
4	in	in	ADP	IN	_	_	_	_	_
5	response	response	NOUN	NN	Number=Sing	_	_	_	_
6	to	to	ADP	IN	_	_	_	_	_
7	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
8	combination	combination	NOUN	NN	Number=Sing	_	_	_	_
9	of	of	ADP	IN	_	_	_	_	_
10	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
11	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
12	12	12	NUM	CD	NumType=Card	_	_	_	_
13	and	and	CCONJ	CC	_	_	_	_	_
14	IL	Il	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
15	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
16	2	2	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
17	.	.	PUNCT	.	_	_	_	_	_
18	Furthermore	furthermore	ADV	RB	_	_	_	_	SpaceAfter=No
19	,	,	PUNCT	,	_	_	_	_	_
20	these	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
21	findings	finding	NOUN	NNS	Number=Plur	_	_	_	_
22	indicate	indicate	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
23	that	that	SCONJ	IN	_	_	_	_	_
24	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
25	optimal	optimal	ADJ	JJ	Degree=Pos	_	_	_	_
26	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
27	of	of	ADP	IN	_	_	_	_	_
28	T	t	PROPN	NNP	Number=Sing	_	_	_	_
29	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
30	by	by	ADP	IN	_	_	_	_	_
31	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
32	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
33	12	12	NUM	CD	NumType=Card	_	_	_	_
34	and	and	CCONJ	CC	_	_	_	_	_
35	IL	Il	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
36	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
37	2	2	NUM	CD	NumType=Card	_	_	_	_
38	may	may	AUX	MD	VerbForm=Fin	_	_	_	_
39	depend	depend	VERB	VB	VerbForm=Inf	_	_	_	_
40	on	on	ADP	IN	_	_	_	_	_
41	an	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
42	interaction	interaction	NOUN	NN	Number=Sing	_	_	_	_
43	between	between	ADP	IN	_	_	_	_	_
44	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
45	p38	p38	NUM	CD	NumType=Card	_	_	_	_
46	MAP	map	NOUN	NN	Number=Sing	_	_	_	_
47	kinase	kinase	NOUN	NN	Number=Sing	_	_	_	_
48	and	and	CCONJ	CC	_	_	_	_	_
49	Janus	Janus	PROPN	NNP	Number=Sing	_	_	_	_
50	kinase	kinase	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
51	/STAT	/stat	SCONJ	IN	_	_	_	_	_
52	signaling	signale	VERB	VBG	VerbForm=Ger	_	_	_	_
53	pathways	pathway	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
54	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 3037
# text = Document 003003369 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	003003369	003003369	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 3038
# text = Interleukin-6 production in hemorrhagic shock is accompanied by neutrophil recruitment and lung injury.
1	Interleukin	Interleukin	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
2	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
3	6	6	NUM	CD	NumType=Card	_	_	_	_
4	production	production	NOUN	NN	Number=Sing	_	_	_	_
5	in	in	ADP	IN	_	_	_	_	_
6	hemorrhagic	hemorrhagic	ADJ	JJ	Degree=Pos	_	_	_	_
7	shock	shock	NOUN	NN	Number=Sing	_	_	_	_
8	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
9	accompanied	accompany	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
10	by	by	ADP	IN	_	_	_	_	_
11	neutrophil	neutrophil	NOUN	NN	Number=Sing	_	_	_	_
12	recruitment	recruitment	NOUN	NN	Number=Sing	_	_	_	_
13	and	and	CCONJ	CC	_	_	_	_	_
14	lung	lung	NOUN	NN	Number=Sing	_	_	_	_
15	injury	injury	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
16	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 3039
# text = Hemorrhagic shock (HS) initiates an inflammatory cascade that includes the production of cytokines and recruitment of neutrophils (PMN) and may progress to organ failure, inducing acute respiratory distress syndrome (ARDS).
1	Hemorrhagic	Hemorrhagic	ADJ	JJ	Degree=Pos	_	_	_	_
2	shock	shock	NOUN	NN	Number=Sing	_	_	_	_
3	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
4	HS	HS	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
5	)	)	PUNCT	-RRB-	_	_	_	_	_
6	initiates	initiate	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
7	an	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
8	inflammatory	inflammatory	ADJ	JJ	Degree=Pos	_	_	_	_
9	cascade	cascade	NOUN	NN	Number=Sing	_	_	_	_
10	that	that	PRON	WDT	PronType=Rel	_	_	_	_
11	includes	include	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
12	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
13	production	production	NOUN	NN	Number=Sing	_	_	_	_
14	of	of	ADP	IN	_	_	_	_	_
15	cytokines	cytokine	NOUN	NNS	Number=Plur	_	_	_	_
16	and	and	CCONJ	CC	_	_	_	_	_
17	recruitment	recruitment	NOUN	NN	Number=Sing	_	_	_	_
18	of	of	ADP	IN	_	_	_	_	_
19	neutrophils	neutrophil	NOUN	NNS	Number=Plur	_	_	_	_
20	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
21	PMN	PMN	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
22	)	)	PUNCT	-RRB-	_	_	_	_	_
23	and	and	CCONJ	CC	_	_	_	_	_
24	may	may	AUX	MD	VerbForm=Fin	_	_	_	_
25	progress	progress	VERB	VB	VerbForm=Inf	_	_	_	_
26	to	to	PART	TO	_	_	_	_	_
27	organ	organ	VERB	VB	VerbForm=Inf	_	_	_	_
28	failure	failure	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
29	,	,	PUNCT	,	_	_	_	_	_
30	inducing	induce	VERB	VBG	VerbForm=Ger	_	_	_	_
31	acute	acute	ADJ	JJ	Degree=Pos	_	_	_	_
32	respiratory	respiratory	NOUN	NN	Number=Sing	_	_	_	_
33	distress	distress	NOUN	NN	Number=Sing	_	_	_	_
34	syndrome	syndrome	NOUN	NN	Number=Sing	_	_	_	_
35	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
36	ARDS	ARDS	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
37	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
38	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3040
# text = To examine the hypothesis that interleukin-6 (IL-6) contributes to PMN infiltration and lung damage in HS, we examined the lungs of rats subjected to unresuscitated and resuscitated HS for the production of IL-6 and activation of Stat3.
1	To	to	PART	TO	_	_	_	_	_
2	examine	examine	VERB	VB	VerbForm=Inf	_	_	_	_
3	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
4	hypothesis	hypothesis	NOUN	NN	Number=Sing	_	_	_	_
5	that	that	PRON	WDT	PronType=Rel	_	_	_	_
6	interleukin	interleukin	VERB	VBG	Tense=Pres|VerbForm=Part	_	_	_	SpaceAfter=No
7	-	-	SYM	SYM	_	_	_	_	SpaceAfter=No
8	6	6	NUM	CD	NumType=Card	_	_	_	_
9	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
10	IL	Il	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
11	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
12	6	6	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
13	)	)	PUNCT	-RRB-	_	_	_	_	_
14	contributes	contribute	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
15	to	to	PART	TO	_	_	_	_	_
16	PMN	Pmn	VERB	VB	VerbForm=Inf	_	_	_	_
17	infiltration	infiltration	NOUN	NN	Number=Sing	_	_	_	_
18	and	and	CCONJ	CC	_	_	_	_	_
19	lung	lung	NOUN	NN	Number=Sing	_	_	_	_
20	damage	damage	NOUN	NN	Number=Sing	_	_	_	_
21	in	in	ADP	IN	_	_	_	_	_
22	HS	HS	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
23	,	,	PUNCT	,	_	_	_	_	_
24	we	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
25	examined	examin	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
26	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
27	lungs	lung	NOUN	NNS	Number=Plur	_	_	_	_
28	of	of	ADP	IN	_	_	_	_	_
29	rats	rat	NOUN	NNS	Number=Plur	_	_	_	_
30	subjected	subject	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
31	to	to	PART	TO	_	_	_	_	_
32	unresuscitated	unresuscitated	VERB	VB	VerbForm=Inf	_	_	_	_
33	and	and	CCONJ	CC	_	_	_	_	_
34	resuscitated	resuscitate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
35	HS	H	NOUN	NNS	Number=Plur	_	_	_	_
36	for	for	ADP	IN	_	_	_	_	_
37	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
38	production	production	NOUN	NN	Number=Sing	_	_	_	_
39	of	of	ADP	IN	_	_	_	_	_
40	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
41	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
42	6	6	NUM	CD	NumType=Card	_	_	_	_
43	and	and	CCONJ	CC	_	_	_	_	_
44	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
45	of	of	ADP	IN	_	_	_	_	_
46	Stat3	Stat3	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
47	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3041
# text = Using semiquantitative RT-PCR, we found a striking increase in IL-6 mRNA levels only in resuscitated HS, with peak levels observed 1 h after initiation of resuscitation.
1	Using	use	VERB	VBG	VerbForm=Ger	_	_	_	_
2	semiquantitative	semiquantitative	ADJ	JJ	Degree=Pos	_	_	_	_
3	RT	Rt	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
4	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
5	PCR	PCR	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
6	,	,	PUNCT	,	_	_	_	_	_
7	we	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
8	found	find	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
9	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
10	striking	strik	VERB	VBG	VerbForm=Ger	_	_	_	_
11	increase	increase	NOUN	NN	Number=Sing	_	_	_	_
12	in	in	ADP	IN	_	_	_	_	_
13	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
14	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
15	6	6	NUM	CD	NumType=Card	_	_	_	_
16	mRNA	mRNa	NOUN	NN	Number=Sing	_	_	_	_
17	levels	level	NOUN	NNS	Number=Plur	_	_	_	_
18	only	only	ADV	RB	_	_	_	_	_
19	in	in	ADP	IN	_	_	_	_	_
20	resuscitated	resuscitated	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
21	HS	HS	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
22	,	,	PUNCT	,	_	_	_	_	_
23	with	with	ADP	IN	_	_	_	_	_
24	peak	peak	NOUN	NN	Number=Sing	_	_	_	_
25	levels	level	NOUN	NNS	Number=Plur	_	_	_	_
26	observed	observe	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
27	1	1	NUM	CD	NumType=Card	_	_	_	_
28	h	h	NOUN	NN	Number=Sing	_	_	_	_
29	after	after	ADP	IN	_	_	_	_	_
30	initiation	initiation	NOUN	NN	Number=Sing	_	_	_	_
31	of	of	ADP	IN	_	_	_	_	_
32	resuscitation	resuscitation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
33	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3042
# text = Increased IL-6 protein expression was localized to bronchial and alveolar cells.
1	Increased	increase	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
2	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
3	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
4	6	6	NUM	CD	NumType=Card	_	_	_	_
5	protein	protein	NOUN	NN	Number=Sing	_	_	_	_
6	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
7	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
8	localized	localize	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
9	to	to	ADP	IN	_	_	_	_	_
10	bronchial	bronchial	ADJ	JJ	Degree=Pos	_	_	_	_
11	and	and	CCONJ	CC	_	_	_	_	_
12	alveolar	alveolar	ADJ	JJ	Degree=Pos	_	_	_	_
13	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
14	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3043
# text = Electrophoretic mobility shift assay of protein extracts from shock lungs exhibited an increase in Stat3 activation with kinetics similar to IL-6 mRNA.
1	Electrophoretic	Electrophoretic	ADJ	JJ	Degree=Pos	_	_	_	_
2	mobility	mobility	NOUN	NN	Number=Sing	_	_	_	_
3	shift	shift	NOUN	NN	Number=Sing	_	_	_	_
4	assay	assay	NOUN	NN	Number=Sing	_	_	_	_
5	of	of	ADP	IN	_	_	_	_	_
6	protein	protein	NOUN	NN	Number=Sing	_	_	_	_
7	extracts	extract	NOUN	NNS	Number=Plur	_	_	_	_
8	from	from	ADP	IN	_	_	_	_	_
9	shock	shock	NOUN	NN	Number=Sing	_	_	_	_
10	lungs	lung	NOUN	NNS	Number=Plur	_	_	_	_
11	exhibited	exhibit	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
12	an	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
13	increase	increase	NOUN	NN	Number=Sing	_	_	_	_
14	in	in	ADP	IN	_	_	_	_	_
15	Stat3	Stat3	NUM	CD	NumType=Card	_	_	_	_
16	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
17	with	with	ADP	IN	_	_	_	_	_
18	kinetics	kinetic	NOUN	NNS	Number=Plur	_	_	_	_
19	similar	similar	ADJ	JJ	Degree=Pos	_	_	_	_
20	to	to	ADP	IN	_	_	_	_	_
21	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
22	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
23	6	6	NUM	CD	NumType=Card	_	_	_	_
24	mRNA	mRNa	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
25	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3044
# text = In situ DNA binding assay determined Stat3 activation predominantly within alveoli.
1	In	in	ADP	IN	_	_	_	_	_
2	situ	situ	NOUN	NN	Number=Sing	_	_	_	_
3	DNA	dna	NOUN	NN	Number=Sing	_	_	_	_
4	binding	bind	VERB	VBG	VerbForm=Ger	_	_	_	_
5	assay	assay	ADV	RB	_	_	_	_	_
6	determined	determined	ADJ	JJ	Degree=Pos	_	_	_	_
7	Stat3	Stat3	NOUN	NN	Number=Sing	_	_	_	_
8	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
9	predominantly	predominantly	ADV	RB	_	_	_	_	_
10	within	within	ADP	IN	_	_	_	_	_
11	alveoli	alveoli	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
12	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3045
# text = Intratracheal instillation of IL-6 alone into normal rats resulted in PMN infiltration into lung interstitium and alveoli, marked elevation of bronchoalveolar lavage cellularity, and increased wet-to-dry ratio.
1	Intratracheal	Intratracheal	ADJ	JJ	Degree=Pos	_	_	_	_
2	instillation	instillation	NOUN	NN	Number=Sing	_	_	_	_
3	of	of	ADP	IN	_	_	_	_	_
4	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
5	-	-	SYM	SYM	_	_	_	_	SpaceAfter=No
6	6	6	NUM	CD	NumType=Card	_	_	_	_
7	alone	alone	ADV	RB	_	_	_	_	_
8	into	into	ADP	IN	_	_	_	_	_
9	normal	normal	ADJ	JJ	Degree=Pos	_	_	_	_
10	rats	rat	NOUN	NNS	Number=Plur	_	_	_	_
11	resulted	result	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
12	in	in	ADP	IN	_	_	_	_	_
13	PMN	Pmn	PROPN	NNP	Number=Sing	_	_	_	_
14	infiltration	infiltration	NOUN	NN	Number=Sing	_	_	_	_
15	into	into	ADP	IN	_	_	_	_	_
16	lung	lung	NOUN	NN	Number=Sing	_	_	_	_
17	interstitium	interstitium	NOUN	NN	Number=Sing	_	_	_	_
18	and	and	CCONJ	CC	_	_	_	_	_
19	alveoli	alveoli	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
20	,	,	PUNCT	,	_	_	_	_	_
21	marked	mark	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
22	elevation	elevation	NOUN	NN	Number=Sing	_	_	_	_
23	of	of	ADP	IN	_	_	_	_	_
24	bronchoalveolar	bronchoalveolar	ADJ	JJ	Degree=Pos	_	_	_	_
25	lavage	lavage	NOUN	NN	Number=Sing	_	_	_	_
26	cellularity	cellularity	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
27	,	,	PUNCT	,	_	_	_	_	_
28	and	and	CCONJ	CC	_	_	_	_	_
29	increased	increase	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
30	wet	wet	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
31	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
32	to	to	ADP	IN	_	_	_	_	SpaceAfter=No
33	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
34	dry	dry	ADJ	JJ	Degree=Pos	_	_	_	_
35	ratio	ratio	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
36	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3046
# text = These findings indicate that IL-6 production and Stat3 activation occur early in HS and may contribute to PMN-mediated lung injury, including ARDS after HS.
1	These	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
2	findings	finding	NOUN	NNS	Number=Plur	_	_	_	_
3	indicate	indicate	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
4	that	that	SCONJ	IN	_	_	_	_	_
5	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
6	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
7	6	6	NUM	CD	NumType=Card	_	_	_	_
8	production	production	NOUN	NN	Number=Sing	_	_	_	_
9	and	and	CCONJ	CC	_	_	_	_	_
10	Stat3	Stat3	NUM	CD	NumType=Card	_	_	_	_
11	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
12	occur	occur	NOUN	NN	Number=Sing	_	_	_	_
13	early	early	ADV	RB	Degree=Pos	_	_	_	_
14	in	in	ADP	IN	_	_	_	_	_
15	HS	HS	PROPN	NNP	Number=Sing	_	_	_	_
16	and	and	CCONJ	CC	_	_	_	_	_
17	may	may	AUX	MD	VerbForm=Fin	_	_	_	_
18	contribute	contribute	VERB	VB	VerbForm=Inf	_	_	_	_
19	to	to	PART	TO	_	_	_	_	_
20	PMN	Pmn	VERB	VB	VerbForm=Inf	_	_	_	SpaceAfter=No
21	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
22	mediated	mediate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
23	lung	lung	NOUN	NN	Number=Sing	_	_	_	_
24	injury	injury	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
25	,	,	PUNCT	,	_	_	_	_	_
26	including	include	VERB	VBG	VerbForm=Ger	_	_	_	_
27	ARDS	ARDS	PROPN	NNP	Number=Sing	_	_	_	_
28	after	after	ADP	IN	_	_	_	_	_
29	HS	HS	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
30	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 3047
# text = Document 003003371 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	003003371	003003371	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 3048
# text = A novel B cell-derived coactivator potentiates the activation of immunoglobulin promoters by octamer-binding transcription factors.
1	A	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
2	novel	novel	NOUN	NN	Number=Sing	_	_	_	_
3	B	b	NOUN	NN	Number=Sing	_	_	_	_
4	cell	cell	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
5	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
6	derived	derive	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
7	coactivator	coactivator	NOUN	NN	Number=Sing	_	_	_	_
8	potentiates	potentiate	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
9	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
10	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
11	of	of	ADP	IN	_	_	_	_	_
12	immunoglobulin	immunoglobulin	ADJ	JJ	Degree=Pos	_	_	_	_
13	promoters	promoter	NOUN	NNS	Number=Plur	_	_	_	_
14	by	by	ADP	IN	_	_	_	_	_
15	octamer	octamer	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
16	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
17	binding	bind	VERB	VBG	VerbForm=Ger	_	_	_	_
18	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
19	factors	factor	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
20	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 3049
# text = A novel B cell-restricted activity, required for high levels of octamer/Oct-dependent transcription from an immunoglobulin heavy chain (IgH) promoter, was detected in an in vitro system consisting of HeLa cell-derived extracts complemented with fractionated B cell nuclear proteins.
1	A	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
2	novel	novel	NOUN	NN	Number=Sing	_	_	_	_
3	B	b	NOUN	NN	Number=Sing	_	_	_	_
4	cell	cell	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
5	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
6	restricted	restrict	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
7	activity	activity	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
8	,	,	PUNCT	,	_	_	_	_	_
9	required	require	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
10	for	for	ADP	IN	_	_	_	_	_
11	high	high	ADJ	JJ	Degree=Pos	_	_	_	_
12	levels	level	NOUN	NNS	Number=Plur	_	_	_	_
13	of	of	ADP	IN	_	_	_	_	_
14	octamer	octamer	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
15	/	/	PUNCT	,	_	_	_	_	SpaceAfter=No
16	Oct	Oct	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
17	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
18	dependent	dependent	ADJ	JJ	Degree=Pos	_	_	_	_
19	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
20	from	from	ADP	IN	_	_	_	_	_
21	an	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
22	immunoglobulin	immunoglobulin	ADJ	JJ	Degree=Pos	_	_	_	_
23	heavy	heavy	ADJ	JJ	Degree=Pos	_	_	_	_
24	chain	chain	NOUN	NN	Number=Sing	_	_	_	_
25	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
26	IgH	IgH	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
27	)	)	PUNCT	-RRB-	_	_	_	_	_
28	promoter	promoter	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
29	,	,	PUNCT	,	_	_	_	_	_
30	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
31	detected	detect	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
32	in	in	ADP	IN	_	_	_	_	_
33	an	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
34	in	in	ADP	IN	_	_	_	_	_
35	vitro	vitro	NOUN	NN	Number=Sing	_	_	_	_
36	system	system	NOUN	NN	Number=Sing	_	_	_	_
37	consisting	consiste	VERB	VBG	VerbForm=Ger	_	_	_	_
38	of	of	ADP	IN	_	_	_	_	_
39	HeLa	HeLa	PROPN	NNP	Number=Sing	_	_	_	_
40	cell	cell	ADV	RB	Degree=Pos	_	_	_	SpaceAfter=No
41	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
42	derived	derive	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
43	extracts	extract	NOUN	NNS	Number=Plur	_	_	_	_
44	complemented	complement	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
45	with	with	ADP	IN	_	_	_	_	_
46	fractionated	fractionate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
47	B	b	NOUN	NN	Number=Sing	_	_	_	_
48	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
49	nuclear	nuclear	ADJ	JJ	Degree=Pos	_	_	_	_
50	proteins	protein	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
51	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3050
# text = The factor responsible for this activity was designated Oct coactivator from B cells (OCA-B).
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	factor	factor	NOUN	NN	Number=Sing	_	_	_	_
3	responsible	responsible	ADJ	JJ	Degree=Pos	_	_	_	_
4	for	for	ADP	IN	_	_	_	_	_
5	this	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
6	activity	activity	NOUN	NN	Number=Sing	_	_	_	_
7	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
8	designated	designate	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
9	Oct	Oct	PROPN	NNP	Number=Sing	_	_	_	_
10	coactivator	coactivator	NOUN	NN	Number=Sing	_	_	_	_
11	from	from	ADP	IN	_	_	_	_	_
12	B	b	ADJ	JJ	Degree=Pos	_	_	_	_
13	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
14	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
15	OCA	Oca	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
16	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
17	B	b	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
18	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
19	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3051
# text = OCA-B stimulates the transcription from an IgH promoter in conjunction with either Oct-1 or Oct-2 but shows no significant effect on the octamer/Oct-dependent transcription of the ubiquitously expressed histone H2B promoter and the transcription of USF- and Sp1-regulated promoters.
1	OCA	Oca	INTJ	UH	_	_	_	_	SpaceAfter=No
2	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
3	B	B	PROPN	NNP	Number=Sing	_	_	_	_
4	stimulates	stimulate	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
5	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
6	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
7	from	from	ADP	IN	_	_	_	_	_
8	an	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
9	IgH	Igh	PROPN	NNP	Number=Sing	_	_	_	_
10	promoter	promoter	NOUN	NN	Number=Sing	_	_	_	_
11	in	in	ADP	IN	_	_	_	_	_
12	conjunction	conjunction	NOUN	NN	Number=Sing	_	_	_	_
13	with	with	ADP	IN	_	_	_	_	_
14	either	either	CCONJ	CC	_	_	_	_	_
15	Oct	Oct	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
16	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
17	1	1	NUM	CD	NumType=Card	_	_	_	_
18	or	or	CCONJ	CC	_	_	_	_	_
19	Oct	Oct	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
20	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
21	2	2	NUM	CD	NumType=Card	_	_	_	_
22	but	but	CCONJ	CC	_	_	_	_	_
23	shows	show	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
24	no	no	DET	DT	_	_	_	_	_
25	significant	significant	ADJ	JJ	Degree=Pos	_	_	_	_
26	effect	effect	NOUN	NN	Number=Sing	_	_	_	_
27	on	on	ADP	IN	_	_	_	_	_
28	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
29	octamer	octamer	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
30	/	/	PUNCT	,	_	_	_	_	SpaceAfter=No
31	Oct	Oct	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
32	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
33	dependent	dependent	ADJ	JJ	Degree=Pos	_	_	_	_
34	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
35	of	of	ADP	IN	_	_	_	_	_
36	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
37	ubiquitously	ubiquitously	ADV	RB	_	_	_	_	_
38	expressed	express	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
39	histone	histone	NOUN	NN	Number=Sing	_	_	_	_
40	H2B	H2b	NOUN	NN	Number=Sing	_	_	_	_
41	promoter	promoter	NOUN	NN	Number=Sing	_	_	_	_
42	and	and	CCONJ	CC	_	_	_	_	_
43	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
44	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
45	of	of	ADP	IN	_	_	_	_	_
46	USF	USF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
47	-	-	PUNCT	,	_	_	_	_	_
48	and	and	CCONJ	CC	_	_	_	_	_
49	Sp1	sp1	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
50	-regulated	-regulate	ADJ	JJ	Degree=Pos	_	_	_	_
51	promoters	promoter	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
52	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3052
# text = Taken together, our results suggest that OCA-B is a tissue-, promoter-, and factor-specific coactivator and that OCA-B may be a major determinant for B cell-specific activation of immunoglobulin promoters.
1	Taken	take	PROPN	NNP	Number=Sing	_	_	_	_
2	together	together	ADV	RB	_	_	_	_	SpaceAfter=No
3	,	,	PUNCT	,	_	_	_	_	_
4	our	we	PRON	PRP$	Number=Plur|Person=1|Poss=Yes|PronType=Prs	_	_	_	_
5	results	result	NOUN	NNS	Number=Plur	_	_	_	_
6	suggest	suggest	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
7	that	that	SCONJ	IN	_	_	_	_	_
8	OCA	OCa	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
9	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
10	B	b	PROPN	NNP	Number=Sing	_	_	_	_
11	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
12	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
13	tissue	tissue	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
14	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
15	,	,	PUNCT	,	_	_	_	_	_
16	promoter	promoter	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
17	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
18	,	,	PUNCT	,	_	_	_	_	_
19	and	and	CCONJ	CC	_	_	_	_	_
20	factor	factor	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
21	-specific	-specific	ADJ	JJ	Degree=Pos	_	_	_	_
22	coactivator	coactivator	NOUN	NN	Number=Sing	_	_	_	_
23	and	and	CCONJ	CC	_	_	_	_	_
24	that	that	SCONJ	IN	_	_	_	_	_
25	OCA	OCa	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
26	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
27	B	b	NOUN	NN	Number=Sing	_	_	_	_
28	may	may	AUX	MD	VerbForm=Fin	_	_	_	_
29	be	be	AUX	VB	VerbForm=Inf	_	_	_	_
30	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
31	major	major	ADJ	JJ	Degree=Pos	_	_	_	_
32	determinant	determinant	NOUN	NN	Number=Sing	_	_	_	_
33	for	for	ADP	IN	_	_	_	_	_
34	B	b	ADJ	JJ	Degree=Pos	_	_	_	_
35	cell	cell	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
36	-specific	-specific	ADJ	JJ	Degree=Pos	_	_	_	_
37	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
38	of	of	ADP	IN	_	_	_	_	_
39	immunoglobulin	immunoglobulin	ADJ	JJ	Degree=Pos	_	_	_	_
40	promoters	promoter	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
41	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3053
# text = In light of the evidence showing physical and functional interactions between Oct factors and OCA-B, we propose a mechanism of action for OCA-B and discuss the implications of OCA-B for the transcriptional regulation of other tissue-specific promoters.
1	In	in	ADP	IN	_	_	_	_	_
2	light	light	NOUN	NN	Number=Sing	_	_	_	_
3	of	of	ADP	IN	_	_	_	_	_
4	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
5	evidence	evidence	NOUN	NN	Number=Sing	_	_	_	_
6	showing	show	VERB	VBG	VerbForm=Ger	_	_	_	_
7	physical	physical	ADJ	JJ	Degree=Pos	_	_	_	_
8	and	and	CCONJ	CC	_	_	_	_	_
9	functional	functional	ADJ	JJ	Degree=Pos	_	_	_	_
10	interactions	interaction	NOUN	NNS	Number=Plur	_	_	_	_
11	between	between	ADP	IN	_	_	_	_	_
12	Oct	Oct	PROPN	NNP	Number=Sing	_	_	_	_
13	factors	factor	NOUN	NNS	Number=Plur	_	_	_	_
14	and	and	CCONJ	CC	_	_	_	_	_
15	OCA	OCa	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
16	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
17	B	b	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
18	,	,	PUNCT	,	_	_	_	_	_
19	we	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
20	propose	propose	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
21	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
22	mechanism	mechanism	NOUN	NN	Number=Sing	_	_	_	_
23	of	of	ADP	IN	_	_	_	_	_
24	action	action	NOUN	NN	Number=Sing	_	_	_	_
25	for	for	ADP	IN	_	_	_	_	_
26	OCA	OCA	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
27	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
28	B	B	PROPN	NNP	Number=Sing	_	_	_	_
29	and	and	CCONJ	CC	_	_	_	_	_
30	discuss	discuss	VERB	VB	VerbForm=Inf	_	_	_	_
31	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
32	implications	implication	NOUN	NNS	Number=Plur	_	_	_	_
33	of	of	ADP	IN	_	_	_	_	_
34	OCA	OCa	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
35	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
36	B	b	PROPN	NNP	Number=Sing	_	_	_	_
37	for	for	ADP	IN	_	_	_	_	_
38	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
39	transcriptional	transcriptional	ADJ	JJ	Degree=Pos	_	_	_	_
40	regulation	regulation	NOUN	NN	Number=Sing	_	_	_	_
41	of	of	ADP	IN	_	_	_	_	_
42	other	other	ADJ	JJ	Degree=Pos	_	_	_	_
43	tissue	tissue	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
44	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
45	specific	specific	ADJ	JJ	Degree=Pos	_	_	_	_
46	promoters	promoter	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
47	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 3054
# text = Document 003003373 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	003003373	003003373	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 3055
# text = Heterogeneity of antigen molecules recognized by anti-tax1 monoclonal antibody Lt-4 in cell lines bearing human T cell leukemia virus type I and related retroviruses.
1	Heterogeneity	Heterogeneity	NOUN	NN	Number=Sing	_	_	_	_
2	of	of	ADP	IN	_	_	_	_	_
3	antigen	antigen	ADJ	JJ	Degree=Pos	_	_	_	_
4	molecules	molecule	NOUN	NNS	Number=Plur	_	_	_	_
5	recognized	recognize	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
6	by	by	ADP	IN	_	_	_	_	_
7	anti-tax1	anti-tax1	NUM	CD	NumType=Card	_	_	_	_
8	monoclonal	monoclonal	ADJ	JJ	Degree=Pos	_	_	_	_
9	antibody	antibody	ADJ	JJ	Degree=Pos	_	_	_	_
10	Lt	Lt	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
11	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
12	4	4	NUM	CD	NumType=Card	_	_	_	_
13	in	in	ADP	IN	_	_	_	_	_
14	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
15	lines	line	NOUN	NNS	Number=Plur	_	_	_	_
16	bearing	bear	VERB	VBG	VerbForm=Ger	_	_	_	_
17	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
18	T	t	PROPN	NNP	Number=Sing	_	_	_	_
19	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
20	leukemia	leukemia	NOUN	NN	Number=Sing	_	_	_	_
21	virus	virus	NOUN	NN	Number=Sing	_	_	_	_
22	type	type	NOUN	NN	Number=Sing	_	_	_	_
23	I	I	PRON	PRP	Case=Nom|Number=Sing|Person=1|PronType=Prs	_	_	_	_
24	and	and	CCONJ	CC	_	_	_	_	_
25	related	relate	ADJ	JJ	Degree=Pos	_	_	_	_
26	retroviruses	retroviruse	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
27	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 3056
# text = Using a monoclonal antibody, Lt-4, directed against human T cell leukemia virus type I (HTLV-I) trans-activator (tax1) antigen, we examined the expression of tax1 and related antigens in a variety of T cell lines bearing HTLV-I and related retroviruses, simian T cell leukemia virus type I (STLV-I) and HTLV-II, by immunofluorescence and immunoblot assays. Lt-4 reacted with all HTLV-I-bearing cell lines tested and five out of eight simian cell lines bearing STLV-I, but not with an HTLV-II-bearing cell line.
1	Using	use	VERB	VBG	VerbForm=Ger	_	_	_	_
2	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
3	monoclonal	monoclonal	ADJ	JJ	Degree=Pos	_	_	_	_
4	antibody	antibody	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
5	,	,	PUNCT	,	_	_	_	_	_
6	Lt	Lt	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
7	-	-	SYM	SYM	_	_	_	_	SpaceAfter=No
8	4	4	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
9	,	,	PUNCT	,	_	_	_	_	_
10	directed	direct	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
11	against	against	ADP	IN	_	_	_	_	_
12	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
13	T	t	PROPN	NNP	Number=Sing	_	_	_	_
14	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
15	leukemia	leukemia	NOUN	NN	Number=Sing	_	_	_	_
16	virus	virus	NOUN	NN	Number=Sing	_	_	_	_
17	type	type	NOUN	NN	Number=Sing	_	_	_	_
18	I	I	PRON	PRP	Case=Nom|Number=Sing|Person=1|PronType=Prs	_	_	_	_
19	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
20	HTLV	HTLV	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
21	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
22	I	I	PRON	PRP	Case=Nom|Number=Sing|Person=1|PronType=Prs	_	_	_	SpaceAfter=No
23	)	)	PUNCT	-RRB-	_	_	_	_	_
24	trans	tran	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
25	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
26	activator	activator	NOUN	NN	Number=Sing	_	_	_	_
27	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
28	tax1	tax1	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
29	)	)	PUNCT	-RRB-	_	_	_	_	_
30	antigen	antigen	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
31	,	,	PUNCT	,	_	_	_	_	_
32	we	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
33	examined	examin	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
34	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
35	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
36	of	of	ADP	IN	_	_	_	_	_
37	tax1	tax1	NUM	CD	NumType=Card	_	_	_	_
38	and	and	CCONJ	CC	_	_	_	_	_
39	related	related	ADJ	JJ	Degree=Pos	_	_	_	_
40	antigens	antigen	NOUN	NNS	Number=Plur	_	_	_	_
41	in	in	ADP	IN	_	_	_	_	_
42	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
43	variety	variety	NOUN	NN	Number=Sing	_	_	_	_
44	of	of	ADP	IN	_	_	_	_	_
45	T	t	PROPN	NNP	Number=Sing	_	_	_	_
46	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
47	lines	line	NOUN	NNS	Number=Plur	_	_	_	_
48	bearing	bear	VERB	VBG	VerbForm=Ger	_	_	_	_
49	HTLV	HTLV	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
50	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
51	I	I	PRON	PRP	Case=Nom|Number=Sing|Person=1|PronType=Prs	_	_	_	_
52	and	and	CCONJ	CC	_	_	_	_	_
53	related	related	ADJ	JJ	Degree=Pos	_	_	_	_
54	retroviruses	retroviruse	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
55	,	,	PUNCT	,	_	_	_	_	_
56	simian	simian	ADJ	JJ	Degree=Pos	_	_	_	_
57	T	t	PROPN	NNP	Number=Sing	_	_	_	_
58	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
59	leukemia	leukemia	NOUN	NN	Number=Sing	_	_	_	_
60	virus	virus	NOUN	NN	Number=Sing	_	_	_	_
61	type	type	NOUN	NN	Number=Sing	_	_	_	_
62	I	I	PRON	PRP	Case=Nom|Number=Sing|Person=1|PronType=Prs	_	_	_	_
63	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
64	STLV	STLV	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
65	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
66	I	I	PRON	PRP	Case=Nom|Number=Sing|Person=1|PronType=Prs	_	_	_	SpaceAfter=No
67	)	)	PUNCT	-RRB-	_	_	_	_	_
68	and	and	CCONJ	CC	_	_	_	_	_
69	HTLV	HTLV	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
70	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
71	II	II	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
72	,	,	PUNCT	,	_	_	_	_	_
73	by	by	ADP	IN	_	_	_	_	_
74	immunofluorescence	immunofluorescence	NOUN	NN	Number=Sing	_	_	_	_
75	and	and	CCONJ	CC	_	_	_	_	_
76	immunoblot	immunoblot	ADV	RB	_	_	_	_	_
77	assays.	assays.	ADP	IN	_	_	_	_	_
78	Lt	Lt	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
79	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
80	4	4	NUM	CD	NumType=Card	_	_	_	_
81	reacted	react	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
82	with	with	ADP	IN	_	_	_	_	_
83	all	all	DET	DT	_	_	_	_	_
84	HTLV	HTLV	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
85	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
86	I	I	PRON	PRP	Case=Nom|Number=Sing|Person=1|PronType=Prs	_	_	_	SpaceAfter=No
87	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
88	bearing	bear	VERB	VBG	VerbForm=Ger	_	_	_	_
89	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
90	lines	line	NOUN	NNS	Number=Plur	_	_	_	_
91	tested	test	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
92	and	and	CCONJ	CC	_	_	_	_	_
93	five	five	NUM	CD	NumType=Card	_	_	_	_
94	out	out	ADP	IN	_	_	_	_	_
95	of	of	ADP	IN	_	_	_	_	_
96	eight	eight	NUM	CD	NumType=Card	_	_	_	_
97	simian	simian	ADJ	JJ	Degree=Pos	_	_	_	_
98	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
99	lines	line	NOUN	NNS	Number=Plur	_	_	_	_
100	bearing	bear	VERB	VBG	VerbForm=Ger	_	_	_	_
101	STLV	STLV	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
102	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
103	I	I	PRON	PRP	Case=Nom|Number=Sing|Person=1|PronType=Prs	_	_	_	SpaceAfter=No
104	,	,	PUNCT	,	_	_	_	_	_
105	but	but	CCONJ	CC	_	_	_	_	_
106	not	not	ADV	RB	_	_	_	_	_
107	with	with	ADP	IN	_	_	_	_	_
108	an	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
109	HTLV	HTLV	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
110	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
111	II	II	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
112	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
113	bearing	bear	VERB	VBG	VerbForm=Ger	_	_	_	_
114	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
115	line	line	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
116	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3057
# text = Lt-4 detected 40 kd tax1 antigen molecules in most HTLV-I-bearing cell lines except one cell line that expressed 39 kd tax1 antigen.
1	Lt	Lt	VERB	VB	Mood=Imp|VerbForm=Fin	_	_	_	SpaceAfter=No
2	-	-	SYM	SYM	_	_	_	_	SpaceAfter=No
3	4	4	NUM	CD	NumType=Card	_	_	_	_
4	detected	detect	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
5	40	40	NUM	CD	NumType=Card	_	_	_	_
6	kd	kd	NOUN	NN	Number=Sing	_	_	_	_
7	tax1	tax1	NUM	CD	NumType=Card	_	_	_	_
8	antigen	antigen	ADJ	JJ	Degree=Pos	_	_	_	_
9	molecules	molecule	NOUN	NNS	Number=Plur	_	_	_	_
10	in	in	ADP	IN	_	_	_	_	_
11	most	most	ADJ	JJS	Degree=Sup	_	_	_	_
12	HTLV	HTLV	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
13	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
14	I	I	PRON	PRP	Case=Nom|Number=Sing|Person=1|PronType=Prs	_	_	_	SpaceAfter=No
15	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
16	bearing	bear	VERB	VBG	VerbForm=Ger	_	_	_	_
17	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
18	lines	line	NOUN	NNS	Number=Plur	_	_	_	_
19	except	except	ADP	IN	_	_	_	_	_
20	one	one	NUM	CD	NumType=Card	_	_	_	_
21	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
22	line	line	NOUN	NN	Number=Sing	_	_	_	_
23	that	that	PRON	WDT	PronType=Rel	_	_	_	_
24	expressed	express	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
25	39	39	NUM	CD	NumType=Card	_	_	_	_
26	kd	kd	NOUN	NN	Number=Sing	_	_	_	_
27	tax1	tax1	NUM	CD	NumType=Card	_	_	_	_
28	antigen	antigen	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
29	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3058
# text = In the STLV-I-bearing T cell lines, tax1-related antigen molecules detected by Lt-4 were heterogeneous, having molecular weights in the range of 36-41 kd.
1	In	in	ADP	IN	_	_	_	_	_
2	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
3	STLV	Stlv	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
4	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
5	I	I	PRON	PRP	Case=Nom|Number=Sing|Person=1|PronType=Prs	_	_	_	SpaceAfter=No
6	-bearing	-bear	VERB	VBG	VerbForm=Ger	_	_	_	_
7	T	t	PROPN	NNP	Number=Sing	_	_	_	_
8	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
9	lines	line	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
10	,	,	PUNCT	,	_	_	_	_	_
11	tax1	tax1	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
12	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
13	related	related	ADJ	JJ	Degree=Pos	_	_	_	_
14	antigen	antigen	ADJ	JJ	Degree=Pos	_	_	_	_
15	molecules	molecule	NOUN	NNS	Number=Plur	_	_	_	_
16	detected	detect	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
17	by	by	ADP	IN	_	_	_	_	_
18	Lt	Lt	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
19	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
20	4	4	NUM	CD	NumType=Card	_	_	_	_
21	were	be	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
22	heterogeneous	heterogeneous	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
23	,	,	PUNCT	,	_	_	_	_	_
24	having	have	VERB	VBG	VerbForm=Ger	_	_	_	_
25	molecular	molecular	ADJ	JJ	Degree=Pos	_	_	_	_
26	weights	weight	NOUN	NNS	Number=Plur	_	_	_	_
27	in	in	ADP	IN	_	_	_	_	_
28	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
29	range	range	NOUN	NN	Number=Sing	_	_	_	_
30	of	of	ADP	IN	_	_	_	_	_
31	36	36	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
32	-	-	SYM	SYM	_	_	_	_	SpaceAfter=No
33	41	41	NUM	CD	NumType=Card	_	_	_	_
34	kd	k	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
35	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 3059
# text = Document 003003375 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	003003375	003003375	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 3060
# text = Cutting edge: TCR stimulation by antibody and bacterial superantigen induces Stat3 activation in human T cells.
1	Cutting	cut	NOUN	NN	Number=Sing	_	_	_	_
2	edge	edge	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
3	:	:	PUNCT	:	_	_	_	_	_
4	TCR	Tcr	ADJ	JJ	Degree=Pos	_	_	_	_
5	stimulation	stimulation	NOUN	NN	Number=Sing	_	_	_	_
6	by	by	ADP	IN	_	_	_	_	_
7	antibody	antibody	ADJ	JJ	Degree=Pos	_	_	_	_
8	and	and	CCONJ	CC	_	_	_	_	_
9	bacterial	bacterial	ADJ	JJ	Degree=Pos	_	_	_	_
10	superantigen	superantigen	NUM	CD	NumType=Card	_	_	_	_
11	induces	induce	NOUN	NNS	Number=Plur	_	_	_	_
12	Stat3	Stat3	NUM	CD	NumType=Card	_	_	_	_
13	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
14	in	in	ADP	IN	_	_	_	_	_
15	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
16	T	t	PROPN	NNP	Number=Sing	_	_	_	_
17	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
18	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 3061
# text = Recent data show that TCR/CD3 stimulation induces activation of Stat5 in murine T cells.
1	Recent	recent	ADJ	JJ	Degree=Pos	_	_	_	_
2	data	data	NOUN	NN	Number=Sing	_	_	_	_
3	show	show	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
4	that	that	SCONJ	IN	_	_	_	_	_
5	TCR/	TCR/	ADP	IN	Abbr=Yes	_	_	_	SpaceAfter=No
6	CD3	CD3	NUM	CD	NumType=Card	_	_	_	_
7	stimulation	stimulation	NOUN	NN	Number=Sing	_	_	_	_
8	induces	induce	NOUN	NNS	Number=Plur	_	_	_	_
9	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
10	of	of	ADP	IN	_	_	_	_	_
11	Stat5	stat5	PROPN	NNP	Number=Sing	_	_	_	_
12	in	in	ADP	IN	_	_	_	_	_
13	murine	murine	PROPN	NNP	Number=Sing	_	_	_	_
14	T	t	PROPN	NNP	Number=Sing	_	_	_	_
15	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
16	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3062
# text = Here, we show that CD3 ligation by mAb and Staphylococcal enterotoxin (SE) induce a rapid, gradually accumulating, long-lasting tyrosine, and serine phosphorylation of Stat3 (but not Stat5) in allogen-specific human CD4+ T cell lines.
1	Here	here	ADV	RB	PronType=Dem	_	_	_	SpaceAfter=No
2	,	,	PUNCT	,	_	_	_	_	_
3	we	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
4	show	show	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
5	that	that	SCONJ	IN	_	_	_	_	_
6	CD3	CD3	NUM	CD	NumType=Card	_	_	_	_
7	ligation	ligation	NOUN	NN	Number=Sing	_	_	_	_
8	by	by	ADP	IN	_	_	_	_	_
9	mAb	mAb	PROPN	NNP	Number=Sing	_	_	_	_
10	and	and	CCONJ	CC	_	_	_	_	_
11	Staphylococcal	Staphylococcal	PROPN	NNP	Number=Sing	_	_	_	_
12	enterotoxin	enterotoxin	PROPN	NNP	Number=Sing	_	_	_	_
13	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
14	SE	SE	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
15	)	)	PUNCT	-RRB-	_	_	_	_	_
16	induce	induce	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
17	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
18	rapid	rapid	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
19	,	,	PUNCT	,	_	_	_	_	_
20	gradually	gradually	ADV	RB	_	_	_	_	_
21	accumulating	accumulate	VERB	VBG	VerbForm=Ger	_	_	_	SpaceAfter=No
22	,	,	PUNCT	,	_	_	_	_	_
23	long	long	ADV	RB	Degree=Pos	_	_	_	SpaceAfter=No
24	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
25	lasting	lasting	VERB	VBG	VerbForm=Ger	_	_	_	_
26	tyrosine	tyrosine	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
27	,	,	PUNCT	,	_	_	_	_	_
28	and	and	CCONJ	CC	_	_	_	_	_
29	serine	serine	NOUN	NN	Number=Sing	_	_	_	_
30	phosphorylation	phosphorylation	NOUN	NN	Number=Sing	_	_	_	_
31	of	of	ADP	IN	_	_	_	_	_
32	Stat3	Stat3	NOUN	NN	Number=Sing	_	_	_	_
33	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
34	but	but	CCONJ	CC	_	_	_	_	_
35	not	not	ADV	RB	_	_	_	_	_
36	Stat5	Stat5	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
37	)	)	PUNCT	-RRB-	_	_	_	_	_
38	in	in	ADP	IN	_	_	_	_	_
39	allogen	allogen	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
40	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
41	specific	specific	ADJ	JJ	Degree=Pos	_	_	_	_
42	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
43	CD4	CD4	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
44	+	+	SYM	SYM	_	_	_	_	_
45	T	t	NUM	CD	NumType=Card	_	_	_	_
46	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
47	lines	line	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
48	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3063
# text = In contrast, IL-2 induces a rapid and transient tyrosine and serine phosphorylation of Stat3.
1	In	in	ADP	IN	_	_	_	_	_
2	contrast	contrast	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
3	,	,	PUNCT	,	_	_	_	_	_
4	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
5	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
6	2	2	NUM	CD	NumType=Card	_	_	_	_
7	induces	induce	NOUN	NNS	Number=Plur	_	_	_	_
8	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
9	rapid	rapid	ADJ	JJ	Degree=Pos	_	_	_	_
10	and	and	CCONJ	CC	_	_	_	_	_
11	transient	transient	ADJ	JJ	Degree=Pos	_	_	_	_
12	tyrosine	tyrosine	NOUN	NN	Number=Sing	_	_	_	_
13	and	and	CCONJ	CC	_	_	_	_	_
14	serine	serine	NOUN	NN	Number=Sing	_	_	_	_
15	phosphorylation	phosphorylation	NOUN	NN	Number=Sing	_	_	_	_
16	of	of	ADP	IN	_	_	_	_	_
17	Stat3	Stat3	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
18	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3064
# text = Compared with IL-2, CD3 ligation induces a delayed Stat3 binding to oligonucleotide probes from the ICAM-1 and IL-2R alpha promoter.
1	Compared	compare	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
2	with	with	ADP	IN	_	_	_	_	_
3	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
4	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
5	2	2	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
6	,	,	PUNCT	,	_	_	_	_	_
7	CD3	CD3	NUM	CD	NumType=Card	_	_	_	_
8	ligation	ligation	NOUN	NN	Number=Sing	_	_	_	_
9	induces	induce	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
10	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
11	delayed	delayed	ADJ	JJ	Degree=Pos	_	_	_	_
12	Stat3	Stat3	NOUN	NN	Number=Sing	_	_	_	_
13	binding	bind	VERB	VBG	VerbForm=Ger	_	_	_	_
14	to	to	PART	TO	_	_	_	_	_
15	oligonucleotide	oligonucleotide	VERB	VB	VerbForm=Inf	_	_	_	_
16	probes	probe	NOUN	NNS	Number=Plur	_	_	_	_
17	from	from	ADP	IN	_	_	_	_	_
18	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
19	ICAM	ICAm	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
20	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
21	1	1	NUM	CD	NumType=Card	_	_	_	_
22	and	and	CCONJ	CC	_	_	_	_	_
23	IL	Il	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
24	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
25	2R	2r	NOUN	NN	Number=Sing	_	_	_	_
26	alpha	alpha	NOUN	NN	Number=Sing	_	_	_	_
27	promoter	promoter	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
28	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3065
# text = CD3-mediated activation of Stat3 is almost completely inhibited by a Src kinase inhibitor (PP1), whereas IL-2-induced Stat3 activation is unaffected.
1	CD3	CD3	X	LS	_	_	_	_	SpaceAfter=No
2	-mediated	-mediated	ADJ	JJ	Degree=Pos	_	_	_	_
3	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
4	of	of	ADP	IN	_	_	_	_	_
5	Stat3	Stat3	NOUN	NN	Number=Sing	_	_	_	_
6	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
7	almost	almost	ADV	RB	_	_	_	_	_
8	completely	completely	ADV	RB	_	_	_	_	_
9	inhibited	inhibit	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
10	by	by	ADP	IN	_	_	_	_	_
11	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
12	Src	Src	PROPN	NNP	Number=Sing	_	_	_	_
13	kinase	kinase	NOUN	NN	Number=Sing	_	_	_	_
14	inhibitor	inhibitor	NOUN	NN	Number=Sing	_	_	_	_
15	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
16	PP1	Pp1	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
17	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
18	,	,	PUNCT	,	_	_	_	_	_
19	whereas	whereas	SCONJ	IN	_	_	_	_	_
20	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
21	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
22	2	2	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
23	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
24	induced	induce	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
25	Stat3	Stat3	NOUN	NN	Number=Sing	_	_	_	_
26	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
27	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
28	unaffected	unaffected	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
29	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3066
# text = In conclusion, we show that CD3 ligation by mAb and SE triggers a rapid, PP1-sensitive tyrosine and serine phosphorylation of Stat3 in human CD4+ T cells.
1	In	in	ADP	IN	_	_	_	_	_
2	conclusion	conclusion	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
3	,	,	PUNCT	,	_	_	_	_	_
4	we	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
5	show	show	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
6	that	that	SCONJ	IN	_	_	_	_	_
7	CD3	CD3	NUM	CD	NumType=Card	_	_	_	_
8	ligation	ligation	NOUN	NN	Number=Sing	_	_	_	_
9	by	by	ADP	IN	_	_	_	_	_
10	mAb	mAb	PROPN	NNP	Number=Sing	_	_	_	_
11	and	and	CCONJ	CC	_	_	_	_	_
12	SE	SE	PROPN	NNP	Number=Sing	_	_	_	_
13	triggers	trigger	NOUN	NNS	Number=Plur	_	_	_	_
14	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
15	rapid	rapid	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
16	,	,	PUNCT	,	_	_	_	_	_
17	PP1	Pp1	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
18	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
19	sensitive	sensitive	ADJ	JJ	Degree=Pos	_	_	_	_
20	tyrosine	tyrosine	NOUN	NN	Number=Sing	_	_	_	_
21	and	and	CCONJ	CC	_	_	_	_	_
22	serine	serine	NOUN	NN	Number=Sing	_	_	_	_
23	phosphorylation	phosphorylation	NOUN	NN	Number=Sing	_	_	_	_
24	of	of	ADP	IN	_	_	_	_	_
25	Stat3	Stat3	NOUN	NN	Number=Sing	_	_	_	_
26	in	in	ADP	IN	_	_	_	_	_
27	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
28	CD4	CD4	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
29	+	+	SYM	SYM	_	_	_	_	_
30	T	t	NUM	CD	NumType=Card	_	_	_	_
31	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
32	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3067
# text = Moreover, we provide evidence that TCR/CD3 and IL-2 induce Stat3 activation via distinct signaling pathways.
1	Moreover	moreover	ADV	RB	_	_	_	_	SpaceAfter=No
2	,	,	PUNCT	,	_	_	_	_	_
3	we	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
4	provide	provide	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
5	evidence	evidence	NOUN	NN	Number=Sing	_	_	_	_
6	that	that	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
7	TCR/CD3	TCR/CD3	NOUN	NN	Number=Sing	_	_	_	_
8	and	and	CCONJ	CC	_	_	_	_	_
9	IL	Il	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
10	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
11	2	2	NUM	CD	NumType=Card	_	_	_	_
12	induce	induce	NOUN	NN	Number=Sing	_	_	_	_
13	Stat3	Stat3	NUM	CD	NumType=Card	_	_	_	_
14	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
15	via	via	ADP	IN	_	_	_	_	_
16	distinct	distinct	ADJ	JJ	Degree=Pos	_	_	_	_
17	signaling	signaling	NOUN	NN	Number=Sing	_	_	_	_
18	pathways	pathway	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
19	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 3068
# text = Document 003003378 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	003003378	003003378	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 3069
# text = Anti-immunoglobulin
1	Anti-immunoglobulin	Anti-immunoglobulin	PROPN	NNP	Number=Sing	_	_	_	_

# sent_id = 3070
# text = M activates nuclear calcium/calmodulin-dependent protein kinase II in human B lymphocytes.
1	M	m	NOUN	NN	Number=Sing	_	_	_	_
2	activates	activate	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
3	nuclear	nuclear	ADJ	JJ	Degree=Pos	_	_	_	_
4	calcium/calmodulin	calcium/calmodulin	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
5	-dependent	-dependent	ADJ	JJ	Degree=Pos	_	_	_	_
6	protein	protein	NOUN	NN	Number=Sing	_	_	_	_
7	kinase	kinase	NOUN	NN	Number=Sing	_	_	_	_
8	II	ii	NUM	CD	NumType=Card	_	_	_	_
9	in	in	ADP	IN	_	_	_	_	_
10	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
11	B	b	NOUN	NN	Number=Sing	_	_	_	_
12	lymphocytes	lymphocyte	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
13	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 3071
# text = We and others have previously shown that the nuclear protein, Ets-1, is phosphorylated in a calcium-dependent manner after ligation of immunoglobulin
1	We	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
2	and	and	CCONJ	CC	_	_	_	_	_
3	others	other	NOUN	NNS	Number=Plur	_	_	_	_
4	have	have	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
5	previously	previously	ADV	RB	_	_	_	_	_
6	shown	show	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
7	that	that	SCONJ	IN	_	_	_	_	_
8	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
9	nuclear	nuclear	ADJ	JJ	Degree=Pos	_	_	_	_
10	protein	protein	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
11	,	,	PUNCT	,	_	_	_	_	_
12	Ets	Ets	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
13	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
14	1	1	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
15	,	,	PUNCT	,	_	_	_	_	_
16	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
17	phosphorylated	phosphorylate	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
18	in	in	ADP	IN	_	_	_	_	_
19	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
20	calcium	calcium	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
21	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
22	dependent	dependent	ADJ	JJ	Degree=Pos	_	_	_	_
23	manner	manner	NOUN	NN	Number=Sing	_	_	_	_
24	after	after	ADP	IN	_	_	_	_	_
25	ligation	ligation	NOUN	NN	Number=Sing	_	_	_	_
26	of	of	ADP	IN	_	_	_	_	_
27	immunoglobulin	immunoglobulin	NOUN	NN	Number=Sing	_	_	_	_

# sent_id = 3072
# text = (Ig) M on B lymphocytes.
1	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
2	Ig	ig	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
3	)	)	PUNCT	-RRB-	_	_	_	_	_
4	M	m	NOUN	NN	Number=Sing	_	_	_	_
5	on	on	ADP	IN	_	_	_	_	_
6	B	b	ADJ	JJ	Degree=Pos	_	_	_	_
7	lymphocytes	lymphocyte	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
8	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3073
# text = As this phosphorylation was independent of protein kinase C activity, we tested whether a calcium/calmodulin-dependent protein kinase (CaM kinase) might phosphorylate the Ets-1 protein after elevation of intracellular free calcium concentrations.
1	As	as	ADP	IN	_	_	_	_	_
2	this	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
3	phosphorylation	phosphorylation	NOUN	NN	Number=Sing	_	_	_	_
4	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
5	independent	independent	ADJ	JJ	Degree=Pos	_	_	_	_
6	of	of	ADP	IN	_	_	_	_	_
7	protein	protein	NOUN	NN	Number=Sing	_	_	_	_
8	kinase	kinase	NOUN	NN	Number=Sing	_	_	_	_
9	C	C	NOUN	NN	Number=Sing	_	_	_	_
10	activity	activity	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
11	,	,	PUNCT	,	_	_	_	_	_
12	we	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
13	tested	test	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
14	whether	whether	SCONJ	IN	_	_	_	_	_
15	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
16	calcium/calmodulin	calcium/calmodulin	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
17	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
18	dependent	dependent	ADJ	JJ	Degree=Pos	_	_	_	_
19	protein	protein	NOUN	NN	Number=Sing	_	_	_	_
20	kinase	kinase	NOUN	NN	Number=Sing	_	_	_	_
21	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
22	CaM	Cam	NOUN	NN	Number=Sing	_	_	_	_
23	kinase	kinase	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
24	)	)	PUNCT	-RRB-	_	_	_	_	_
25	might	might	AUX	MD	VerbForm=Fin	_	_	_	_
26	phosphorylate	phosphorylate	VERB	VB	VerbForm=Inf	_	_	_	_
27	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
28	Ets	Et	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
29	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
30	1	1	NUM	CD	NumType=Card	_	_	_	_
31	protein	protein	NOUN	NN	Number=Sing	_	_	_	_
32	after	after	ADP	IN	_	_	_	_	_
33	elevation	elevation	NOUN	NN	Number=Sing	_	_	_	_
34	of	of	ADP	IN	_	_	_	_	_
35	intracellular	intracellular	ADJ	JJ	Degree=Pos	_	_	_	_
36	free	free	ADJ	JJ	Degree=Pos	_	_	_	_
37	calcium	calcium	NOUN	NN	Number=Sing	_	_	_	_
38	concentrations	concentration	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
39	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3074
# text = The dephosphorylated form of Ets-1 has been shown to bind to chromatin, suggesting that the operative kinase should be detectable in the nucleus.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	dephosphorylated	dephosphorylate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
3	form	form	NOUN	NN	Number=Sing	_	_	_	_
4	of	of	ADP	IN	_	_	_	_	_
5	Ets	Ets	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
6	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
7	1	1	NUM	CD	NumType=Card	_	_	_	_
8	has	have	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
9	been	be	AUX	VBN	Tense=Past|VerbForm=Part	_	_	_	_
10	shown	show	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
11	to	to	PART	TO	_	_	_	_	_
12	bind	bind	VERB	VB	VerbForm=Inf	_	_	_	_
13	to	to	ADP	IN	_	_	_	_	_
14	chromatin	chromatin	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
15	,	,	PUNCT	,	_	_	_	_	_
16	suggesting	suggest	VERB	VBG	VerbForm=Ger	_	_	_	_
17	that	that	SCONJ	IN	_	_	_	_	_
18	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
19	operative	operative	NOUN	NN	Number=Sing	_	_	_	_
20	kinase	kinase	NOUN	NN	Number=Sing	_	_	_	_
21	should	should	AUX	MD	VerbForm=Fin	_	_	_	_
22	be	be	AUX	VB	VerbForm=Inf	_	_	_	_
23	detectable	detectable	ADJ	JJ	Degree=Pos	_	_	_	_
24	in	in	ADP	IN	_	_	_	_	_
25	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
26	nucleus	nucleus	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
27	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3075
# text = We prepared nuclear extracts from two human B cell lines in which increased intracellular free calcium levels correlated with increased phosphorylation of the Ets-1 protein.
1	We	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
2	prepared	prepare	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
3	nuclear	nuclear	ADJ	JJ	Degree=Pos	_	_	_	_
4	extracts	extract	NOUN	NNS	Number=Plur	_	_	_	_
5	from	from	ADP	IN	_	_	_	_	_
6	two	two	NUM	CD	NumType=Card	_	_	_	_
7	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
8	B	b	NOUN	NN	Number=Sing	_	_	_	_
9	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
10	lines	line	NOUN	NNS	Number=Plur	_	_	_	_
11	in	in	ADP	IN	_	_	_	_	_
12	which	which	PRON	WDT	PronType=Rel	_	_	_	_
13	increased	increase	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
14	intracellular	intracelular	ADJ	JJ	Degree=Pos	_	_	_	_
15	free	free	ADJ	JJ	Degree=Pos	_	_	_	_
16	calcium	calcium	NOUN	NN	Number=Sing	_	_	_	_
17	levels	level	NOUN	NNS	Number=Plur	_	_	_	_
18	correlated	correlate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
19	with	with	ADP	IN	_	_	_	_	_
20	increased	increase	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
21	phosphorylation	phosphorylation	NOUN	NN	Number=Sing	_	_	_	_
22	of	of	ADP	IN	_	_	_	_	_
23	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
24	Ets	et	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
25	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
26	1	1	NUM	CD	NumType=Card	_	_	_	_
27	protein	protein	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
28	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3076
# text = Activity of the CaM kinases was determined using a synthetic peptide substrate both in the absence and presence of an inhibitor specific for the CaM kinase family, KN-62.
1	Activity	activity	NOUN	NN	Number=Sing	_	_	_	_
2	of	of	ADP	IN	_	_	_	_	_
3	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
4	CaM	Cam	NOUN	NN	Number=Sing	_	_	_	_
5	kinases	kinase	NOUN	NNS	Number=Plur	_	_	_	_
6	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
7	determined	determined	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
8	using	use	VERB	VBG	VerbForm=Ger	_	_	_	_
9	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
10	synthetic	synthetic	ADJ	JJ	Degree=Pos	_	_	_	_
11	peptide	peptide	NOUN	NN	Number=Sing	_	_	_	_
12	substrate	substrate	NOUN	NN	Number=Sing	_	_	_	_
13	both	both	CCONJ	CC	_	_	_	_	_
14	in	in	ADP	IN	_	_	_	_	_
15	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
16	absence	absence	NOUN	NN	Number=Sing	_	_	_	_
17	and	and	CCONJ	CC	_	_	_	_	_
18	presence	presence	NOUN	NN	Number=Sing	_	_	_	_
19	of	of	ADP	IN	_	_	_	_	_
20	an	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
21	inhibitor	inhibitor	NOUN	NN	Number=Sing	_	_	_	_
22	specific	specific	ADJ	JJ	Degree=Pos	_	_	_	_
23	for	for	ADP	IN	_	_	_	_	_
24	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
25	CaM	CaM	PROPN	NNP	Number=Sing	_	_	_	_
26	kinase	kinase	NOUN	NN	Number=Sing	_	_	_	_
27	family	family	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
28	,	,	PUNCT	,	_	_	_	_	_
29	KN	KN	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
30	-	-	SYM	SYM	_	_	_	_	SpaceAfter=No
31	62	62	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
32	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3077
# text = Stimulation of cells with anti-IgM led to increased activity of a nuclear kinase that could phosphorylate the peptide, and this activity was reduced by 10 microM KN-62.
1	Stimulation	Stimulation	NOUN	NN	Number=Sing	_	_	_	_
2	of	of	ADP	IN	_	_	_	_	_
3	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
4	with	with	ADP	IN	_	_	_	_	_
5	anti-IgM	anti-Igm	NOUN	NN	Number=Sing	_	_	_	_
6	led	lead	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
7	to	to	ADP	IN	_	_	_	_	_
8	increased	increase	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
9	activity	activity	NOUN	NN	Number=Sing	_	_	_	_
10	of	of	ADP	IN	_	_	_	_	_
11	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
12	nuclear	nuclear	ADJ	JJ	Degree=Pos	_	_	_	_
13	kinase	kinase	NOUN	NN	Number=Sing	_	_	_	_
14	that	that	PRON	WDT	PronType=Rel	_	_	_	_
15	could	could	AUX	MD	VerbForm=Fin	_	_	_	_
16	phosphorylate	phosphorylate	VERB	VB	VerbForm=Inf	_	_	_	_
17	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
18	peptide	peptide	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
19	,	,	PUNCT	,	_	_	_	_	_
20	and	and	CCONJ	CC	_	_	_	_	_
21	this	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
22	activity	activity	NOUN	NN	Number=Sing	_	_	_	_
23	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
24	reduced	reduce	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
25	by	by	ADP	IN	_	_	_	_	_
26	10	10	NUM	CD	NumType=Card	_	_	_	_
27	microM	microm	NUM	CD	NumType=Card	_	_	_	_
28	KN	KN	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
29	-	-	SYM	SYM	_	_	_	_	SpaceAfter=No
30	62	62	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
31	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3078
# text = Kinase activity was reduced in lysates preadsorbed using an antibody specific for CaM kinase II.
1	Kinase	Kinase	ADJ	JJ	Degree=Pos	_	_	_	_
2	activity	activity	NOUN	NN	Number=Sing	_	_	_	_
3	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
4	reduced	reduce	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
5	in	in	ADP	IN	_	_	_	_	_
6	lysates	lysate	NOUN	NNS	Number=Plur	_	_	_	_
7	preadsorbed	preadsor	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
8	using	use	VERB	VBG	VerbForm=Ger	_	_	_	_
9	an	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
10	antibody	antibody	NOUN	NN	Number=Sing	_	_	_	_
11	specific	specific	ADJ	JJ	Degree=Pos	_	_	_	_
12	for	for	ADP	IN	_	_	_	_	_
13	CaM	CaM	PROPN	NNP	Number=Sing	_	_	_	_
14	kinase	kinase	NOUN	NN	Number=Sing	_	_	_	_
15	II	ii	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
16	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3079
# text = Two-dimensional phosphopeptide maps of the Ets-1 protein from cells incubated with ionomycin or anti-IgM contained two unique phosphopeptides that were absent in untreated cells.
1	Two	two	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
2	-	-	PUNCT	:	_	_	_	_	SpaceAfter=No
3	dimensional	dimensional	ADJ	JJ	Degree=Pos	_	_	_	_
4	phosphopeptide	phosphopeptide	NOUN	NN	Number=Sing	_	_	_	_
5	maps	map	NOUN	NNS	Number=Plur	_	_	_	_
6	of	of	ADP	IN	_	_	_	_	_
7	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
8	Ets	et	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
9	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
10	1	1	NUM	CD	NumType=Card	_	_	_	_
11	protein	protein	NOUN	NN	Number=Sing	_	_	_	_
12	from	from	ADP	IN	_	_	_	_	_
13	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
14	incubated	incubate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
15	with	with	ADP	IN	_	_	_	_	_
16	ionomycin	ionomycin	NOUN	NN	Number=Sing	_	_	_	_
17	or	or	CCONJ	CC	_	_	_	_	_
18	anti	anti	X	AFX	_	_	_	_	SpaceAfter=No
19	-IgM	-Igm	ADJ	JJ	Degree=Pos	_	_	_	_
20	contained	contain	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
21	two	two	NUM	CD	NumType=Card	_	_	_	_
22	unique	unique	ADJ	JJ	Degree=Pos	_	_	_	_
23	phosphopeptides	phosphopeptide	NOUN	NNS	Number=Plur	_	_	_	_
24	that	that	PRON	WDT	PronType=Rel	_	_	_	_
25	were	be	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
26	absent	absend	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
27	in	in	ADP	IN	_	_	_	_	_
28	untreated	untreated	ADJ	JJ	Degree=Pos	_	_	_	_
29	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
30	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3080
# text = Incubation of isolated Ets-1 protein with purified CaM kinase II produced phosphorylation of peptides that migrated identically to those found in cells incubated with either anti-IgM or ionomycin.
1	Incubation	incubation	NOUN	NN	Number=Sing	_	_	_	_
2	of	of	ADP	IN	_	_	_	_	_
3	isolated	isolate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
4	Ets	Et	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
5	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
6	1	1	NUM	CD	NumType=Card	_	_	_	_
7	protein	protein	NOUN	NN	Number=Sing	_	_	_	_
8	with	with	ADP	IN	_	_	_	_	_
9	purified	purify	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
10	CaM	Cam	NOUN	NN	Number=Sing	_	_	_	_
11	kinase	kinase	NOUN	NN	Number=Sing	_	_	_	_
12	II	ii	PRON	PRP	Case=Nom|Number=Sing|Person=1|PronType=Prs	_	_	_	_
13	produced	produce	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
14	phosphorylation	phosphorylation	NOUN	NN	Number=Sing	_	_	_	_
15	of	of	ADP	IN	_	_	_	_	_
16	peptides	peptide	NOUN	NNS	Number=Plur	_	_	_	_
17	that	that	PRON	WDT	PronType=Rel	_	_	_	_
18	migrated	migrate	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
19	identically	identically	ADV	RB	_	_	_	_	_
20	to	to	ADP	IN	_	_	_	_	_
21	those	those	PRON	DT	Number=Plur|PronType=Dem	_	_	_	_
22	found	find	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
23	in	in	ADP	IN	_	_	_	_	_
24	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
25	incubated	incubate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
26	with	with	ADP	IN	_	_	_	_	_
27	either	either	CCONJ	CC	_	_	_	_	_
28	anti-IgM	anti-Igm	ADJ	JJ	Degree=Pos	_	_	_	_
29	or	or	CCONJ	CC	_	_	_	_	_
30	ionomycin	ionomycin	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
31	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3081
# text = These data suggest a model of signal transduction by the antigen receptor on B lymphocytes in which increased intracellular free calcium can rapidly activate nuclear CaM kinase II, potentially resulting in phosphorylation and regulation of DNA-binding proteins.
1	These	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
2	data	data	NOUN	NN	Number=Sing	_	_	_	_
3	suggest	suggest	VERB	VB	VerbForm=Inf	_	_	_	_
4	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
5	model	model	NOUN	NN	Number=Sing	_	_	_	_
6	of	of	ADP	IN	_	_	_	_	_
7	signal	signal	NOUN	NN	Number=Sing	_	_	_	_
8	transduction	transduction	NOUN	NN	Number=Sing	_	_	_	_
9	by	by	ADP	IN	_	_	_	_	_
10	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
11	antigen	antigen	ADJ	JJ	Degree=Pos	_	_	_	_
12	receptor	receptor	NOUN	NN	Number=Sing	_	_	_	_
13	on	on	ADP	IN	_	_	_	_	_
14	B	b	ADJ	JJ	Degree=Pos	_	_	_	_
15	lymphocytes	lymphocyte	NOUN	NNS	Number=Plur	_	_	_	_
16	in	in	ADP	IN	_	_	_	_	_
17	which	which	PRON	WDT	PronType=Rel	_	_	_	_
18	increased	increase	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
19	intracellular	intracelular	ADJ	JJ	Degree=Pos	_	_	_	_
20	free	free	ADJ	JJ	Degree=Pos	_	_	_	_
21	calcium	calcium	NOUN	NN	Number=Sing	_	_	_	_
22	can	can	AUX	MD	VerbForm=Fin	_	_	_	_
23	rapidly	rapidly	ADV	RB	_	_	_	_	_
24	activate	activate	VERB	VB	VerbForm=Inf	_	_	_	_
25	nuclear	nuclear	ADJ	JJ	Degree=Pos	_	_	_	_
26	CaM	Cam	NOUN	NN	Number=Sing	_	_	_	_
27	kinase	kinase	NOUN	NN	Number=Sing	_	_	_	_
28	II	ii	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
29	,	,	PUNCT	,	_	_	_	_	_
30	potentially	potentially	ADV	RB	_	_	_	_	_
31	resulting	result	VERB	VBG	VerbForm=Ger	_	_	_	_
32	in	in	ADP	IN	_	_	_	_	_
33	phosphorylation	phosphorylation	NOUN	NN	Number=Sing	_	_	_	_
34	and	and	CCONJ	CC	_	_	_	_	_
35	regulation	regulation	NOUN	NN	Number=Sing	_	_	_	_
36	of	of	ADP	IN	_	_	_	_	_
37	DNA	dna	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
38	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
39	binding	binding	VERB	VBG	VerbForm=Ger	_	_	_	_
40	proteins	protein	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
41	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 3082
# text = Document 003003384 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	003003384	003003384	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 3083
# text = Regulation of the balance of cytokine production and the signal transducer and activator of transcription (STAT) transcription factor activity by cytokines and inflammatory synovial fluids.
1	Regulation	regulation	NOUN	NN	Number=Sing	_	_	_	_
2	of	of	ADP	IN	_	_	_	_	_
3	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
4	balance	balance	NOUN	NN	Number=Sing	_	_	_	_
5	of	of	ADP	IN	_	_	_	_	_
6	cytokine	cytokine	NOUN	NN	Number=Sing	_	_	_	_
7	production	production	NOUN	NN	Number=Sing	_	_	_	_
8	and	and	CCONJ	CC	_	_	_	_	_
9	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
10	signal	signal	ADJ	JJ	Degree=Pos	_	_	_	_
11	transducer	transducer	NOUN	NN	Number=Sing	_	_	_	_
12	and	and	CCONJ	CC	_	_	_	_	_
13	activator	activator	NOUN	NN	Number=Sing	_	_	_	_
14	of	of	ADP	IN	_	_	_	_	_
15	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
16	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
17	STAT	STAT	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
18	)	)	PUNCT	-RRB-	_	_	_	_	_
19	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
20	factor	factor	NOUN	NN	Number=Sing	_	_	_	_
21	activity	activity	NOUN	NN	Number=Sing	_	_	_	_
22	by	by	ADP	IN	_	_	_	_	_
23	cytokines	cytokine	NOUN	NNS	Number=Plur	_	_	_	_
24	and	and	CCONJ	CC	_	_	_	_	_
25	inflammatory	inflammatory	ADJ	JJ	Degree=Pos	_	_	_	_
26	synovial	synovial	ADJ	JJ	Degree=Pos	_	_	_	_
27	fluids	fluid	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
28	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 3084
# text = The balance between type 1 and 2 T helper cell cytokine production plays an important role in several animal models of autoimmunity, and skewed patterns of cytokine expression have been described in human inflammatory diseases.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	balance	balance	NOUN	NN	Number=Sing	_	_	_	_
3	between	between	ADP	IN	_	_	_	_	_
4	type	type	NOUN	NN	Number=Sing	_	_	_	_
5	1	1	NUM	CD	NumType=Card	_	_	_	_
6	and	and	CCONJ	CC	_	_	_	_	_
7	2	2	NUM	CD	NumType=Card	_	_	_	_
8	T	t	PROPN	NNP	Number=Sing	_	_	_	_
9	helper	helper	NOUN	NN	Number=Sing	_	_	_	_
10	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
11	cytokine	cytokine	NOUN	NN	Number=Sing	_	_	_	_
12	production	production	NOUN	NN	Number=Sing	_	_	_	_
13	plays	play	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
14	an	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
15	important	important	ADJ	JJ	Degree=Pos	_	_	_	_
16	role	role	NOUN	NN	Number=Sing	_	_	_	_
17	in	in	ADP	IN	_	_	_	_	_
18	several	several	ADJ	JJ	Degree=Pos	_	_	_	_
19	animal	animal	NOUN	NN	Number=Sing	_	_	_	_
20	models	model	NOUN	NNS	Number=Plur	_	_	_	_
21	of	of	ADP	IN	_	_	_	_	_
22	autoimmunity	autoimmunity	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
23	,	,	PUNCT	,	_	_	_	_	_
24	and	and	CCONJ	CC	_	_	_	_	_
25	skewed	skew	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
26	patterns	pattern	NOUN	NNS	Number=Plur	_	_	_	_
27	of	of	ADP	IN	_	_	_	_	_
28	cytokine	cytokine	NOUN	NN	Number=Sing	_	_	_	_
29	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
30	have	have	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
31	been	be	AUX	VBN	Tense=Past|VerbForm=Part	_	_	_	_
32	described	describe	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
33	in	in	ADP	IN	_	_	_	_	_
34	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
35	inflammatory	inflammatory	ADJ	JJ	Degree=Pos	_	_	_	_
36	diseases	diseasis	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
37	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3085
# text = Many cytokines activate signal transducer and activation of transcription (STAT) transcription factors, which, in turn, activate transcription of inflammatory effector genes.
1	Many	many	ADJ	JJ	Degree=Pos	_	_	_	_
2	cytokines	cytokine	NOUN	NNS	Number=Plur	_	_	_	_
3	activate	activate	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
4	signal	signal	ADJ	JJ	Degree=Pos	_	_	_	_
5	transducer	transducer	NOUN	NN	Number=Sing	_	_	_	_
6	and	and	CCONJ	CC	_	_	_	_	_
7	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
8	of	of	ADP	IN	_	_	_	_	_
9	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
10	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
11	STAT	STAT	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
12	)	)	PUNCT	-RRB-	_	_	_	_	_
13	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
14	factors	factor	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
15	,	,	PUNCT	,	_	_	_	_	_
16	which	which	PRON	WDT	PronType=Rel	_	_	_	SpaceAfter=No
17	,	,	PUNCT	,	_	_	_	_	_
18	in	in	ADP	IN	_	_	_	_	_
19	turn	turn	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
20	,	,	PUNCT	,	_	_	_	_	_
21	activate	activate	ADJ	JJ	Degree=Pos	_	_	_	_
22	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
23	of	of	ADP	IN	_	_	_	_	_
24	inflammatory	inflammatory	ADJ	JJ	Degree=Pos	_	_	_	_
25	effector	effector	NOUN	NN	Number=Sing	_	_	_	_
26	genes	gene	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
27	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3086
# text = We used mononuclear cell priming cultures and inflammatory synovial fluids (SFs) derived from arthritis patients to examine the regulation of cytokine production and STAT activity by an inflammatory synovial microenvironment.
1	We	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
2	used	use	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
3	mononuclear	mononuclear	NOUN	NN	Number=Sing	_	_	_	_
4	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
5	priming	priming	VERB	VBG	VerbForm=Ger	_	_	_	_
6	cultures	culture	NOUN	NNS	Number=Plur	_	_	_	_
7	and	and	CCONJ	CC	_	_	_	_	_
8	inflammatory	inflammatory	ADJ	JJ	Degree=Pos	_	_	_	_
9	synovial	synovial	ADJ	JJ	Degree=Pos	_	_	_	_
10	fluids	fluid	NOUN	NNS	Number=Plur	_	_	_	_
11	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
12	SFs	Sfs	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
13	)	)	PUNCT	-RRB-	_	_	_	_	_
14	derived	derive	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
15	from	from	ADP	IN	_	_	_	_	_
16	arthritis	arthritis	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
17	patients	patient	NOUN	NN	Number=Sing	_	_	_	_
18	to	to	PART	TO	_	_	_	_	_
19	examine	examine	VERB	VB	VerbForm=Inf	_	_	_	_
20	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
21	regulation	regulation	NOUN	NN	Number=Sing	_	_	_	_
22	of	of	ADP	IN	_	_	_	_	_
23	cytokine	cytokine	NOUN	NN	Number=Sing	_	_	_	_
24	production	production	NOUN	NN	Number=Sing	_	_	_	_
25	and	and	CCONJ	CC	_	_	_	_	_
26	STAT	Stat	NOUN	NN	Number=Sing	_	_	_	_
27	activity	activity	NOUN	NN	Number=Sing	_	_	_	_
28	by	by	ADP	IN	_	_	_	_	_
29	an	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
30	inflammatory	inflammatory	ADJ	JJ	Degree=Pos	_	_	_	_
31	synovial	synovial	ADJ	JJ	Degree=Pos	_	_	_	_
32	microenvironment	microenvironment	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
33	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3087
# text = Exposure to SFs during priming resulted in an 81% inhibition of interferon (IFN)-gamma, but not interleukin (IL) 4, production by effector cells generated in priming cultures.
1	Exposure	exposure	VERB	VB	Mood=Imp|VerbForm=Fin	_	_	_	_
2	to	to	PART	TO	_	_	_	_	_
3	SFs	SF	VERB	VB	VerbForm=Inf	_	_	_	_
4	during	during	ADP	IN	_	_	_	_	_
5	priming	priming	NOUN	NN	Number=Sing	_	_	_	_
6	resulted	result	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
7	in	in	ADP	IN	_	_	_	_	_
8	an	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
9	81	81	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
10	%	%	SYM	NN	Number=Sing	_	_	_	_
11	inhibition	inhibition	NOUN	NN	Number=Sing	_	_	_	_
12	of	of	ADP	IN	_	_	_	_	_
13	interferon	interferon	PROPN	NNP	Number=Sing	_	_	_	_
14	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
15	IFN	IFN	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
16	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
17	-	-	PUNCT	:	_	_	_	_	SpaceAfter=No
18	gamma	gamma	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
19	,	,	PUNCT	,	_	_	_	_	_
20	but	but	CCONJ	CC	_	_	_	_	_
21	not	not	ADV	RB	_	_	_	_	_
22	interleukin	interleukin	NOUN	NN	Number=Sing	_	_	_	_
23	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
24	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
25	)	)	PUNCT	-RRB-	_	_	_	_	_
26	4	4	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
27	,	,	PUNCT	,	_	_	_	_	_
28	production	production	NOUN	NN	Number=Sing	_	_	_	_
29	by	by	ADP	IN	_	_	_	_	_
30	effector	effector	NOUN	NN	Number=Sing	_	_	_	_
31	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
32	generated	generate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
33	in	in	ADP	IN	_	_	_	_	_
34	priming	priming	ADJ	JJ	Degree=Pos	_	_	_	_
35	cultures	culture	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
36	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3088
# text = SF suppression was mediated by IL-4 and IL-10 and inhibition of IL-12 expression, and it was reversed in a dominant fashion by exogenous IL-12.
1	SF	SF	PROPN	NNP	Number=Sing	_	_	_	_
2	suppression	suppression	NOUN	NN	Number=Sing	_	_	_	_
3	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
4	mediated	mediate	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
5	by	by	ADP	IN	_	_	_	_	_
6	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
7	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
8	4	4	NUM	CD	NumType=Card	_	_	_	_
9	and	and	CCONJ	CC	_	_	_	_	_
10	IL	Il	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
11	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
12	10	10	NUM	CD	NumType=Card	_	_	_	_
13	and	and	CCONJ	CC	_	_	_	_	_
14	inhibition	inhibition	NOUN	NN	Number=Sing	_	_	_	_
15	of	of	ADP	IN	_	_	_	_	_
16	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
17	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
18	12	12	NUM	CD	NumType=Card	_	_	_	_
19	expression	expression	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
20	,	,	PUNCT	,	_	_	_	_	_
21	and	and	CCONJ	CC	_	_	_	_	_
22	it	it	PRON	PRP	Case=Nom|Gender=Neut|Number=Sing|Person=3|PronType=Prs	_	_	_	_
23	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
24	reversed	reverse	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
25	in	in	ADP	IN	_	_	_	_	_
26	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
27	dominant	dominant	ADJ	JJ	Degree=Pos	_	_	_	_
28	fashion	fashion	NOUN	NN	Number=Sing	_	_	_	_
29	by	by	ADP	IN	_	_	_	_	_
30	exogenous	exogenous	ADJ	JJ	Degree=Pos	_	_	_	_
31	IL	il	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
32	-	-	SYM	SYM	_	_	_	_	SpaceAfter=No
33	12	12	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
34	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3089
# text = SFs blocked the sustained activity of transcription factor Stat1, but not Stat3, during the priming period, and Stat1 activity was differentially regulated by cytokines in parallel with their positive or negative regulation of IFN-gamma production.
1	SFs	Sfs	NOUN	NNS	Number=Plur	_	_	_	_
2	blocked	block	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
3	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
4	sustained	sustain	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
5	activity	activity	NOUN	NN	Number=Sing	_	_	_	_
6	of	of	ADP	IN	_	_	_	_	_
7	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
8	factor	factor	NOUN	NN	Number=Sing	_	_	_	_
9	Stat1	stat1	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
10	,	,	PUNCT	,	_	_	_	_	_
11	but	but	CCONJ	CC	_	_	_	_	_
12	not	not	ADV	RB	_	_	_	_	_
13	Stat3	Stat3	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
14	,	,	PUNCT	,	_	_	_	_	_
15	during	during	ADP	IN	_	_	_	_	_
16	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
17	priming	priming	ADJ	JJ	Degree=Pos	_	_	_	_
18	period	period	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
19	,	,	PUNCT	,	_	_	_	_	_
20	and	and	CCONJ	CC	_	_	_	_	_
21	Stat1	Stat1	NUM	CD	NumType=Card	_	_	_	_
22	activity	activity	NOUN	NN	Number=Sing	_	_	_	_
23	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
24	differentially	differentially	ADV	RB	_	_	_	_	_
25	regulated	regulate	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
26	by	by	ADP	IN	_	_	_	_	_
27	cytokines	cytokine	NOUN	NNS	Number=Plur	_	_	_	_
28	in	in	ADP	IN	_	_	_	_	_
29	parallel	parallel	NOUN	NN	Number=Sing	_	_	_	_
30	with	with	ADP	IN	_	_	_	_	_
31	their	they	PRON	PRP$	Number=Plur|Person=3|Poss=Yes|PronType=Prs	_	_	_	_
32	positive	positive	ADJ	JJ	Degree=Pos	_	_	_	_
33	or	or	CCONJ	CC	_	_	_	_	_
34	negative	negative	ADJ	JJ	Degree=Pos	_	_	_	_
35	regulation	regulation	NOUN	NN	Number=Sing	_	_	_	_
36	of	of	ADP	IN	_	_	_	_	_
37	IFN	IFN	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
38	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
39	gamma	gamma	NOUN	NN	Number=Sing	_	_	_	_
40	production	production	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
41	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3090
# text = Active Stat3, but not Stat1, was detected in cells from inflamed joints.
1	Active	active	ADJ	JJ	Degree=Pos	_	_	_	_
2	Stat3	Stat3	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
3	,	,	PUNCT	,	_	_	_	_	_
4	but	but	CCONJ	CC	_	_	_	_	_
5	not	not	ADV	RB	_	_	_	_	_
6	Stat1	stat1	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
7	,	,	PUNCT	,	_	_	_	_	_
8	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
9	detected	detect	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
10	in	in	ADP	IN	_	_	_	_	_
11	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
12	from	from	ADP	IN	_	_	_	_	_
13	inflamed	inflam	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
14	joints	joint	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
15	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3091
# text = These results suggest a role for altered balance of Stat1 and Stat3 transcriptional activity in the regulation of T cell differentiation and in the pathogenesis of inflammatory synovitis.
1	These	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
2	results	result	NOUN	NNS	Number=Plur	_	_	_	_
3	suggest	suggest	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
4	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
5	role	role	NOUN	NN	Number=Sing	_	_	_	_
6	for	for	ADP	IN	_	_	_	_	_
7	altered	alter	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
8	balance	balance	NOUN	NN	Number=Sing	_	_	_	_
9	of	of	ADP	IN	_	_	_	_	_
10	Stat1	Stat1	PROPN	NNP	Number=Sing	_	_	_	_
11	and	and	CCONJ	CC	_	_	_	_	_
12	Stat3	Stat3	NUM	CD	NumType=Card	_	_	_	_
13	transcriptional	transcriptional	ADJ	JJ	Degree=Pos	_	_	_	_
14	activity	activity	NOUN	NN	Number=Sing	_	_	_	_
15	in	in	ADP	IN	_	_	_	_	_
16	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
17	regulation	regulation	NOUN	NN	Number=Sing	_	_	_	_
18	of	of	ADP	IN	_	_	_	_	_
19	T	t	PROPN	NNP	Number=Sing	_	_	_	_
20	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
21	differentiation	differentiation	NOUN	NN	Number=Sing	_	_	_	_
22	and	and	CCONJ	CC	_	_	_	_	_
23	in	in	ADP	IN	_	_	_	_	_
24	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
25	pathogenesis	pathogenesis	NOUN	NN	Number=Sing	_	_	_	_
26	of	of	ADP	IN	_	_	_	_	_
27	inflammatory	inflammatory	ADJ	JJ	Degree=Pos	_	_	_	_
28	synovitis	synovitis	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
29	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 3092
# text = Document 003003386 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	003003386	003003386	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 3093
# text = CD40, but not lipopolysaccharide and anti-IgM stimulation of primary B lymphocytes, leads to a persistent nuclear accumulation of RelB.
1	CD40	CD40	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
2	,	,	PUNCT	,	_	_	_	_	_
3	but	but	CCONJ	CC	_	_	_	_	_
4	not	not	ADV	RB	_	_	_	_	_
5	lipopolysaccharide	lipopolysaccharide	ADJ	JJ	Degree=Pos	_	_	_	_
6	and	and	CCONJ	CC	_	_	_	_	_
7	anti-IgM	anti-igm	ADJ	JJ	Degree=Pos	_	_	_	_
8	stimulation	stimulation	NOUN	NN	Number=Sing	_	_	_	_
9	of	of	ADP	IN	_	_	_	_	_
10	primary	primary	ADJ	JJ	Degree=Pos	_	_	_	_
11	B	b	NOUN	NN	Number=Sing	_	_	_	_
12	lymphocytes	lymphocyte	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
13	,	,	PUNCT	,	_	_	_	_	_
14	leads	lead	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
15	to	to	ADP	IN	_	_	_	_	_
16	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
17	persistent	persistent	ADJ	JJ	Degree=Pos	_	_	_	_
18	nuclear	nuclear	ADJ	JJ	Degree=Pos	_	_	_	_
19	accumulation	accumulation	NOUN	NN	Number=Sing	_	_	_	_
20	of	of	ADP	IN	_	_	_	_	_
21	RelB	RelB	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
22	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 3094
# text = In this study we analyzed the effect of CD40 stimulation on the activity and nuclear appearance of Rel/nuclear factor kappaB (NF-kappaB) factors in primary murine B lymphocytes.
1	In	in	ADP	IN	_	_	_	_	_
2	this	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
3	study	study	NOUN	NN	Number=Sing	_	_	_	_
4	we	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
5	analyzed	analyze	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
6	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
7	effect	effect	NOUN	NN	Number=Sing	_	_	_	_
8	of	of	ADP	IN	_	_	_	_	_
9	CD40	CD40	NUM	CD	NumType=Card	_	_	_	_
10	stimulation	stimulation	NOUN	NN	Number=Sing	_	_	_	_
11	on	on	ADP	IN	_	_	_	_	_
12	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
13	activity	activity	NOUN	NN	Number=Sing	_	_	_	_
14	and	and	CCONJ	CC	_	_	_	_	_
15	nuclear	nuclear	ADJ	JJ	Degree=Pos	_	_	_	_
16	appearance	appearance	NOUN	NN	Number=Sing	_	_	_	_
17	of	of	ADP	IN	_	_	_	_	_
18	Rel	Rel	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
19	/	/	PUNCT	,	_	_	_	_	SpaceAfter=No
20	nuclear	nuclear	ADJ	JJ	Degree=Pos	_	_	_	_
21	factor	factor	NOUN	NN	Number=Sing	_	_	_	_
22	kappaB	kappaB	PROPN	NNP	Number=Sing	_	_	_	_
23	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
24	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
25	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
26	kappaB	kappaB	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
27	)	)	PUNCT	-RRB-	_	_	_	_	_
28	factors	factor	NOUN	NNS	Number=Plur	_	_	_	_
29	in	in	ADP	IN	_	_	_	_	_
30	primary	primary	ADJ	JJ	Degree=Pos	_	_	_	_
31	murine	murine	NOUN	NN	Number=Sing	_	_	_	_
32	B	b	NOUN	NN	Number=Sing	_	_	_	_
33	lymphocytes	lymphocyte	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
34	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3095
# text = We show that triggering of CD40 signaling pathway(s) by CD40 ligands expressed on L cells led to strong activation of an NF-kappaB-controlled beta-globin reporter gene in primary B lymphocytes from transgenic mice.
1	We	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
2	show	show	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
3	that	that	SCONJ	IN	_	_	_	_	_
4	triggering	triggering	VERB	VBG	VerbForm=Ger	_	_	_	_
5	of	of	ADP	IN	_	_	_	_	_
6	CD40	CD40	PROPN	NNP	Number=Sing	_	_	_	_
7	signaling	signal	VERB	VBG	VerbForm=Ger	_	_	_	_
8	pathway	pathway	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
9	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
10	s	s	X	AFX	_	_	_	_	SpaceAfter=No
11	)	)	PUNCT	-RRB-	_	_	_	_	_
12	by	by	ADP	IN	_	_	_	_	_
13	CD40	CD40	PROPN	NNP	Number=Sing	_	_	_	_
14	ligands	ligand	NOUN	NNS	Number=Plur	_	_	_	_
15	expressed	express	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
16	on	on	ADP	IN	_	_	_	_	_
17	L	l	ADJ	JJ	Degree=Pos	_	_	_	_
18	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
19	led	lead	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
20	to	to	ADP	IN	_	_	_	_	_
21	strong	strong	ADJ	JJ	Degree=Pos	_	_	_	_
22	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
23	of	of	ADP	IN	_	_	_	_	_
24	an	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
25	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
26	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
27	kappaB	kappaB	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
28	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
29	controlled	control	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
30	beta	beta	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
31	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
32	globin	globin	ADJ	JJ	Degree=Pos	_	_	_	_
33	reporter	reporter	NOUN	NN	Number=Sing	_	_	_	_
34	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
35	in	in	ADP	IN	_	_	_	_	_
36	primary	primary	ADJ	JJ	Degree=Pos	_	_	_	_
37	B	b	NOUN	NN	Number=Sing	_	_	_	_
38	lymphocytes	lymphocyte	NOUN	NNS	Number=Plur	_	_	_	_
39	from	from	ADP	IN	_	_	_	_	_
40	transgenic	transgenic	ADJ	JJ	Degree=Pos	_	_	_	_
41	mice	mouse	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
42	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3096
# text = Analyses of nuclear translocation of individual members of Rel proteins after CD40 induction of primary B cells showed a strong and long-lasting accumulation of RelB and, less pronounced, of c-Rel.
1	Analyses	analysis	NOUN	NNS	Number=Plur	_	_	_	_
2	of	of	ADP	IN	_	_	_	_	_
3	nuclear	nuclear	ADJ	JJ	Degree=Pos	_	_	_	_
4	translocation	translocation	NOUN	NN	Number=Sing	_	_	_	_
5	of	of	ADP	IN	_	_	_	_	_
6	individual	individual	ADJ	JJ	Degree=Pos	_	_	_	_
7	members	member	NOUN	NNS	Number=Plur	_	_	_	_
8	of	of	ADP	IN	_	_	_	_	_
9	Rel	Rel	NOUN	NN	Number=Sing	_	_	_	_
10	proteins	protein	NOUN	NNS	Number=Plur	_	_	_	_
11	after	after	ADP	IN	_	_	_	_	_
12	CD40	CD40	NUM	CD	NumType=Card	_	_	_	_
13	induction	induction	NOUN	NN	Number=Sing	_	_	_	_
14	of	of	ADP	IN	_	_	_	_	_
15	primary	primary	ADJ	JJ	Degree=Pos	_	_	_	_
16	B	b	ADJ	JJ	Degree=Pos	_	_	_	_
17	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
18	showed	show	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
19	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
20	strong	strong	ADJ	JJ	Degree=Pos	_	_	_	_
21	and	and	CCONJ	CC	_	_	_	_	_
22	long	long	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
23	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
24	lasting	lasting	VERB	VBG	VerbForm=Ger	_	_	_	_
25	accumulation	accumulation	NOUN	NN	Number=Sing	_	_	_	_
26	of	of	ADP	IN	_	_	_	_	_
27	RelB	Relb	NOUN	NN	Number=Sing	_	_	_	_
28	and	and	CCONJ	CC	_	_	_	_	SpaceAfter=No
29	,	,	PUNCT	,	_	_	_	_	_
30	less	less	ADV	RBR	Degree=Cmp	_	_	_	_
31	pronounced	pronounce	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
32	,	,	PUNCT	,	_	_	_	_	_
33	of	of	ADP	IN	_	_	_	_	_
34	c	c	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
35	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
36	Rel	Rel	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
37	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3097
# text = LPS stimulation did not give rise to a persistent nuclear accumulation of RelB and c-Rel, whereas nuclear c-Rel, but not RelB, accumulated after B cell receptor stimulation.
1	LPS	Lps	NOUN	NN	Number=Sing	_	_	_	_
2	stimulation	stimulation	NOUN	NN	Number=Sing	_	_	_	_
3	did	do	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
4	not	not	PART	RB	_	_	_	_	_
5	give	give	VERB	VB	VerbForm=Inf	_	_	_	_
6	rise	rise	NOUN	NN	Number=Sing	_	_	_	_
7	to	to	ADP	IN	_	_	_	_	_
8	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
9	persistent	persistent	ADJ	JJ	Degree=Pos	_	_	_	_
10	nuclear	nuclear	ADJ	JJ	Degree=Pos	_	_	_	_
11	accumulation	accumulation	NOUN	NN	Number=Sing	_	_	_	_
12	of	of	ADP	IN	_	_	_	_	_
13	RelB	Relb	NOUN	NN	Number=Sing	_	_	_	_
14	and	and	CCONJ	CC	_	_	_	_	_
15	c	c	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
16	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
17	Rel	Rel	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
18	,	,	PUNCT	,	_	_	_	_	_
19	whereas	whereas	SCONJ	IN	_	_	_	_	_
20	nuclear	nuclear	ADJ	JJ	Degree=Pos	_	_	_	_
21	c	c	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
22	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
23	Rel	Rel	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
24	,	,	PUNCT	,	_	_	_	_	_
25	but	but	CCONJ	CC	_	_	_	_	_
26	not	not	ADV	RB	_	_	_	_	_
27	RelB	Relb	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
28	,	,	PUNCT	,	_	_	_	_	_
29	accumulated	accumulate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
30	after	after	ADP	IN	_	_	_	_	_
31	B	b	NOUN	NN	Number=Sing	_	_	_	_
32	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
33	receptor	receptor	NOUN	NN	Number=Sing	_	_	_	_
34	stimulation	stimulation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
35	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3098
# text = CD40 induced not only nuclear translocation but also de novo synthesis of RelB RNA and protein.
1	CD40	CD40	PROPN	NNP	Number=Sing	_	_	_	_
2	induced	induce	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
3	not	not	ADV	RB	_	_	_	_	_
4	only	only	ADV	RB	_	_	_	_	_
5	nuclear	nuclear	ADJ	JJ	Degree=Pos	_	_	_	_
6	translocation	translocation	NOUN	NN	Number=Sing	_	_	_	_
7	but	but	CCONJ	CC	_	_	_	_	_
8	also	also	ADV	RB	_	_	_	_	_
9	de	de	X	FW	Foreign=Yes	_	_	_	_
10	novo	novo	ADJ	JJ	Degree=Pos	_	_	_	_
11	synthesis	synthesis	NOUN	NN	Number=Sing	_	_	_	_
12	of	of	ADP	IN	_	_	_	_	_
13	RelB	RelB	PROPN	NNP	Number=Sing	_	_	_	_
14	RNA	RNA	PROPN	NNP	Number=Sing	_	_	_	_
15	and	and	CCONJ	CC	_	_	_	_	_
16	protein	protein	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
17	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3099
# text = S107 plasmacytoma cells, which express CD40 but are defective for the nuclear appearance of p50/p65-NF-kappaB, do not express RelB after CD40 stimulation.
1	S107	S107	NUM	CD	NumType=Card	_	_	_	_
2	plasmacytoma	plasmacytoma	NOUN	NN	Number=Sing	_	_	_	_
3	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	,	,	PUNCT	,	_	_	_	_	_
5	which	which	DET	WDT	PronType=Int	_	_	_	_
6	express	express	ADJ	JJ	Degree=Pos	_	_	_	_
7	CD40	CD40	NOUN	NN	Number=Sing	_	_	_	_
8	but	but	CCONJ	CC	_	_	_	_	_
9	are	be	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
10	defective	defective	ADJ	JJ	Degree=Pos	_	_	_	_
11	for	for	ADP	IN	_	_	_	_	_
12	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
13	nuclear	nuclear	ADJ	JJ	Degree=Pos	_	_	_	_
14	appearance	appearance	NOUN	NN	Number=Sing	_	_	_	_
15	of	of	ADP	IN	_	_	_	_	_
16	p50/p65	p50/p65	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
17	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
18	NF	NF	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
19	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
20	kappaB	kappaB	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
21	,	,	PUNCT	,	_	_	_	_	_
22	do	do	AUX	VB	Mood=Imp|VerbForm=Fin	_	_	_	_
23	not	not	PART	RB	_	_	_	_	_
24	express	express	VERB	VB	Mood=Imp|VerbForm=Fin	_	_	_	_
25	RelB	RelB	NOUN	NN	Number=Sing	_	_	_	_
26	after	after	ADP	IN	_	_	_	_	_
27	CD40	CD40	NUM	CD	NumType=Card	_	_	_	_
28	stimulation	stimulation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
29	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3100
# text = In S107 cells stably transfected with relB genes, stimulation of nuclear
1	In	in	ADP	IN	_	_	_	_	_
2	S107	S107	NUM	CD	NumType=Card	_	_	_	_
3	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
4	stably	stably	ADV	RB	_	_	_	_	_
5	transfected	transfect	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
6	with	with	ADP	IN	_	_	_	_	_
7	relB	relb	NOUN	NN	Number=Sing	_	_	_	_
8	genes	gene	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
9	,	,	PUNCT	,	_	_	_	_	_
10	stimulation	stimulation	NOUN	NN	Number=Sing	_	_	_	_
11	of	of	ADP	IN	_	_	_	_	_
12	nuclear	nuclear	ADJ	JJ	Degree=Pos	_	_	_	_

# sent_id = 3101
# text = RelB translocation by CD40 was observed.
1	RelB	Relb	VERB	VB	Mood=Imp|VerbForm=Fin	_	_	_	_
2	translocation	translocation	NOUN	NN	Number=Sing	_	_	_	_
3	by	by	ADP	IN	_	_	_	_	_
4	CD40	CD40	PROPN	NNP	Number=Sing	_	_	_	_
5	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
6	observed	observed	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
7	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3102
# text = These results indicate that stimulation of CD40 signaling pathways exerts a long-lasting stimulatory effect on both the transcription and nuclear translocation of RelB.
1	These	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
2	results	result	NOUN	NNS	Number=Plur	_	_	_	_
3	indicate	indicate	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
4	that	that	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
5	stimulation	stimulation	NOUN	NN	Number=Sing	_	_	_	_
6	of	of	ADP	IN	_	_	_	_	_
7	CD40	CD40	NUM	CD	NumType=Card	_	_	_	_
8	signaling	signaling	VERB	VBG	VerbForm=Ger	_	_	_	_
9	pathways	pathways	NOUN	NNS	Number=Plur	_	_	_	_
10	exerts	exert	NOUN	NNS	Number=Plur	_	_	_	_
11	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
12	long	long	ADV	RB	Degree=Pos	_	_	_	SpaceAfter=No
13	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
14	lasting	lasting	VERB	VBG	VerbForm=Ger	_	_	_	_
15	stimulatory	stimulatory	ADJ	JJ	Degree=Pos	_	_	_	_
16	effect	effect	NOUN	NN	Number=Sing	_	_	_	_
17	on	on	ADP	IN	_	_	_	_	_
18	both	both	CCONJ	CC	_	_	_	_	_
19	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
20	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
21	and	and	CCONJ	CC	_	_	_	_	_
22	nuclear	nuclear	ADJ	JJ	Degree=Pos	_	_	_	_
23	translocation	translocation	NOUN	NN	Number=Sing	_	_	_	_
24	of	of	ADP	IN	_	_	_	_	_
25	RelB	RelB	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
26	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3103
# text = Since LPS and anti-IgM were unable to activate RelB, CD40 appears to trigger a special program of gene expression involved in the proliferation and/or differentiation of B lymphocytes.
1	Since	since	SCONJ	IN	_	_	_	_	_
2	LPS	LPS	PROPN	NNP	Number=Sing	_	_	_	_
3	and	and	CCONJ	CC	_	_	_	_	_
4	anti-IgM	anti-IgM	ADJ	JJ	Degree=Pos	_	_	_	_
5	were	be	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
6	unable	unable	ADJ	JJ	Degree=Pos	_	_	_	_
7	to	to	PART	TO	_	_	_	_	_
8	activate	activate	VERB	VB	VerbForm=Inf	_	_	_	_
9	RelB	RelB	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
10	,	,	PUNCT	,	_	_	_	_	_
11	CD40	CD40	PROPN	NNP	Number=Sing	_	_	_	_
12	appears	appear	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
13	to	to	PART	TO	_	_	_	_	_
14	trigger	trigger	VERB	VB	VerbForm=Inf	_	_	_	_
15	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
16	special	special	ADJ	JJ	Degree=Pos	_	_	_	_
17	program	program	NOUN	NN	Number=Sing	_	_	_	_
18	of	of	ADP	IN	_	_	_	_	_
19	gene	gene	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
20	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
21	involved	involved	ADJ	JJ	Degree=Pos	_	_	_	_
22	in	in	ADP	IN	_	_	_	_	_
23	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
24	proliferation	proliferation	NOUN	NN	Number=Sing	_	_	_	_
25	and	and	CCONJ	CC	_	_	_	_	SpaceAfter=No
26	/	/	PUNCT	,	_	_	_	_	SpaceAfter=No
27	or	or	CCONJ	CC	_	_	_	_	_
28	differentiation	differentiation	NOUN	NN	Number=Sing	_	_	_	_
29	of	of	ADP	IN	_	_	_	_	_
30	B	b	ADJ	JJ	Degree=Pos	_	_	_	_
31	lymphocytes	lymphocyte	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
32	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 3104
# text = Document 003003387 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	003003387	003003387	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 3105
# text = Temperature-induced down-regulation of the glucocorticoid receptor in peripheral blood mononuclear leucocyte in patients with sepsis or septic shock.
1	Temperature	temperature	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
2	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
3	induced	induce	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
4	down	down	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
5	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
6	regulation	regulation	NOUN	NN	Number=Sing	_	_	_	_
7	of	of	ADP	IN	_	_	_	_	_
8	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
9	glucocorticoid	glucocorticoid	ADJ	JJ	Degree=Pos	_	_	_	_
10	receptor	receptor	NOUN	NN	Number=Sing	_	_	_	_
11	in	in	ADP	IN	_	_	_	_	_
12	peripheral	peripheral	ADJ	JJ	Degree=Pos	_	_	_	_
13	blood	blood	NOUN	NN	Number=Sing	_	_	_	_
14	mononuclear	mononuclear	NOUN	NN	Number=Sing	_	_	_	_
15	leucocyte	leucocyte	NOUN	NN	Number=Sing	_	_	_	_
16	in	in	ADP	IN	_	_	_	_	_
17	patients	patient	NOUN	NNS	Number=Plur	_	_	_	_
18	with	with	ADP	IN	_	_	_	_	_
19	sepsis	sepsis	NOUN	NN	Number=Sing	_	_	_	_
20	or	or	CCONJ	CC	_	_	_	_	_
21	septic	septic	ADJ	JJ	Degree=Pos	_	_	_	_
22	shock	shock	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
23	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 3106
# text = OBJECTIVE: Activation of the hypothalamic-pituitary-adrenal axis is of vital importance during critical illness.
1	OBJECTIVE	objective	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
2	:	:	PUNCT	:	_	_	_	_	_
3	Activation	Activation	NOUN	NN	Number=Sing	_	_	_	_
4	of	of	ADP	IN	_	_	_	_	_
5	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
6	hypothalamic	hypothalamic	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
7	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
8	pituitary	pituitary	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
9	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
10	adrenal	adrenal	ADJ	JJ	Degree=Pos	_	_	_	_
11	axis	axis	NOUN	NN	Number=Sing	_	_	_	_
12	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
13	of	of	ADP	IN	_	_	_	_	_
14	vital	vital	ADJ	JJ	Degree=Pos	_	_	_	_
15	importance	importance	NOUN	NN	Number=Sing	_	_	_	_
16	during	during	ADP	IN	_	_	_	_	_
17	critical	critical	ADJ	JJ	Degree=Pos	_	_	_	_
18	illness	illness	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
19	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3107
# text = We have studied the adaptive mechanisms which occur at the level of the glucocorticoid receptor in glucocorticoid target tissues in patients with sepsis or septic shock.
1	We	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
2	have	have	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
3	studied	studie	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
4	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
5	adaptive	adaptive	ADJ	JJ	Degree=Pos	_	_	_	_
6	mechanisms	mechanism	NOUN	NNS	Number=Plur	_	_	_	_
7	which	which	PRON	WDT	PronType=Rel	_	_	_	_
8	occur	occur	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
9	at	at	ADP	IN	_	_	_	_	_
10	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
11	level	level	NOUN	NN	Number=Sing	_	_	_	_
12	of	of	ADP	IN	_	_	_	_	_
13	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
14	glucocorticoid	glucocorticoid	ADJ	JJ	Degree=Pos	_	_	_	_
15	receptor	receptor	NOUN	NN	Number=Sing	_	_	_	_
16	in	in	ADP	IN	_	_	_	_	_
17	glucocorticoid	glucocorticoid	ADJ	JJ	Degree=Pos	_	_	_	_
18	target	target	NOUN	NN	Number=Sing	_	_	_	_
19	tissues	tissue	NOUN	NNS	Number=Plur	_	_	_	_
20	in	in	ADP	IN	_	_	_	_	_
21	patients	patient	NOUN	NNS	Number=Plur	_	_	_	_
22	with	with	ADP	IN	_	_	_	_	_
23	sepsis	sepsis	NOUN	NN	Number=Sing	_	_	_	_
24	or	or	CCONJ	CC	_	_	_	_	_
25	septic	septic	ADJ	JJ	Degree=Pos	_	_	_	_
26	shock	shock	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
27	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3108
# text = DESIGN: The effects of hypercortisolaemia, hyperthermia and cellular composition on number of glucocorticoid receptors per cell and their affinity were evaluated, both in vitro and in vivo, in peripheral blood mononuclear leucocytes of control subjects and in patients with sepsis or septic shock.
1	DESIGN	Design	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
2	:	:	PUNCT	:	_	_	_	_	_
3	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
4	effects	effect	NOUN	NNS	Number=Plur	_	_	_	_
5	of	of	ADP	IN	_	_	_	_	_
6	hypercortisolaemia	hypercortisolaemia	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
7	,	,	PUNCT	,	_	_	_	_	_
8	hyperthermia	hyperthermia	NOUN	NN	Number=Sing	_	_	_	_
9	and	and	CCONJ	CC	_	_	_	_	_
10	cellular	cellular	ADJ	JJ	Degree=Pos	_	_	_	_
11	composition	composition	NOUN	NN	Number=Sing	_	_	_	_
12	on	on	ADP	IN	_	_	_	_	_
13	number	number	NOUN	NN	Number=Sing	_	_	_	_
14	of	of	ADP	IN	_	_	_	_	_
15	glucocorticoid	glucocorticoid	ADJ	JJ	Degree=Pos	_	_	_	_
16	receptors	receptor	NOUN	NNS	Number=Plur	_	_	_	_
17	per	per	ADP	IN	_	_	_	_	_
18	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
19	and	and	CCONJ	CC	_	_	_	_	_
20	their	they	PRON	PRP$	Number=Plur|Person=3|Poss=Yes|PronType=Prs	_	_	_	_
21	affinity	affinity	NOUN	NN	Number=Sing	_	_	_	_
22	were	be	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
23	evaluated	evaluate	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	SpaceAfter=No
24	,	,	PUNCT	,	_	_	_	_	_
25	both	both	CCONJ	CC	_	_	_	_	_
26	in	in	ADP	IN	_	_	_	_	_
27	vitro	vitro	NOUN	NN	Number=Sing	_	_	_	_
28	and	and	CCONJ	CC	_	_	_	_	_
29	in	in	ADP	IN	_	_	_	_	_
30	vivo	vivo	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
31	,	,	PUNCT	,	_	_	_	_	_
32	in	in	ADP	IN	_	_	_	_	_
33	peripheral	peripheral	ADJ	JJ	Degree=Pos	_	_	_	_
34	blood	blood	NOUN	NN	Number=Sing	_	_	_	_
35	mononuclear	mononuclear	ADJ	JJ	Degree=Pos	_	_	_	_
36	leucocytes	leucocyte	NOUN	NNS	Number=Plur	_	_	_	_
37	of	of	ADP	IN	_	_	_	_	_
38	control	control	NOUN	NN	Number=Sing	_	_	_	_
39	subjects	subjects	NOUN	NNS	Number=Plur	_	_	_	_
40	and	and	CCONJ	CC	_	_	_	_	_
41	in	in	ADP	IN	_	_	_	_	_
42	patients	patient	NOUN	NN	Number=Sing	_	_	_	_
43	with	with	ADP	IN	_	_	_	_	_
44	sepsis	sepsis	NOUN	NN	Number=Sing	_	_	_	_
45	or	or	CCONJ	CC	_	_	_	_	_
46	septic	septic	ADJ	JJ	Degree=Pos	_	_	_	_
47	shock	shock	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
48	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3109
# text = SUBJECTS: Fifteen patients (age 25-79) with sepsis or septic shock who were admitted to an intensive care unit were studied.
1	SUBJECTS	sUBJECTs	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
2	:	:	PUNCT	:	_	_	_	_	_
3	Fifteen	fifteen	NUM	CD	NumType=Card	_	_	_	_
4	patients	patient	NOUN	NN	Number=Sing	_	_	_	_
5	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
6	age	age	NOUN	NN	Number=Sing	_	_	_	_
7	25	25	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
8	-	-	SYM	SYM	_	_	_	_	SpaceAfter=No
9	79	79	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
10	)	)	PUNCT	-RRB-	_	_	_	_	_
11	with	with	ADP	IN	_	_	_	_	_
12	sepsis	sepsis	NOUN	NN	Number=Sing	_	_	_	_
13	or	or	CCONJ	CC	_	_	_	_	_
14	septic	septic	ADJ	JJ	Degree=Pos	_	_	_	_
15	shock	shock	NOUN	NN	Number=Sing	_	_	_	_
16	who	who	PRON	WP	PronType=Rel	_	_	_	_
17	were	be	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
18	admitted	admit	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
19	to	to	ADP	IN	_	_	_	_	_
20	an	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
21	intensive	intensive	ADJ	JJ	Degree=Pos	_	_	_	_
22	care	care	NOUN	NN	Number=Sing	_	_	_	_
23	unit	unit	NOUN	NN	Number=Sing	_	_	_	_
24	were	be	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
25	studied	study	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	SpaceAfter=No
26	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3110
# text = The control group consisted of 24 healthy laboratory employees.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	control	control	NOUN	NN	Number=Sing	_	_	_	_
3	group	group	NOUN	NN	Number=Sing	_	_	_	_
4	consisted	consist	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
5	of	of	ADP	IN	_	_	_	_	_
6	24	24	NUM	CD	NumType=Card	_	_	_	_
7	healthy	healthy	ADJ	JJ	Degree=Pos	_	_	_	_
8	laboratory	laboratory	NOUN	NN	Number=Sing	_	_	_	_
9	employees	employee	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
10	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3111
# text = MEASUREMENTS:
1	MEASUREMENTS	Measurements	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
2	:	:	PUNCT	:	_	_	_	_	_

# sent_id = 3112
# text = The binding capacity and affinity of the glucocorticoid receptors were measured and compared to clinical data and the plasma cortisol concentrations.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	binding	binding	VERB	VBG	VerbForm=Ger	_	_	_	_
3	capacity	capacity	NOUN	NN	Number=Sing	_	_	_	_
4	and	and	CCONJ	CC	_	_	_	_	_
5	affinity	affinity	NOUN	NN	Number=Sing	_	_	_	_
6	of	of	ADP	IN	_	_	_	_	_
7	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
8	glucocorticoid	glucocorticoid	ADJ	JJ	Degree=Pos	_	_	_	_
9	receptors	receptor	NOUN	NNS	Number=Plur	_	_	_	_
10	were	be	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
11	measured	measure	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
12	and	and	CCONJ	CC	_	_	_	_	_
13	compared	compare	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
14	to	to	ADP	IN	_	_	_	_	_
15	clinical	clinical	ADJ	JJ	Degree=Pos	_	_	_	_
16	data	data	NOUN	NN	Number=Sing	_	_	_	_
17	and	and	CCONJ	CC	_	_	_	_	_
18	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
19	plasma	plasma	NOUN	NN	Number=Sing	_	_	_	_
20	cortisol	cortisol	NOUN	NN	Number=Sing	_	_	_	_
21	concentrations	concentration	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
22	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3113
# text = RESULTS: Hypercortisolaemia, in vitro, resulted in a decreased affinity and a decreased binding capacity of the glucocorticoid receptor.
1	RESULTS	result	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
2	:	:	PUNCT	:	_	_	_	_	_
3	Hypercortisolaemia	Hypercortisolaemia	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
4	,	,	PUNCT	,	_	_	_	_	_
5	in	in	ADP	IN	_	_	_	_	_
6	vitro	vitro	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
7	,	,	PUNCT	,	_	_	_	_	_
8	resulted	result	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
9	in	in	ADP	IN	_	_	_	_	_
10	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
11	decreased	decreased	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
12	affinity	affinity	NOUN	NN	Number=Sing	_	_	_	_
13	and	and	CCONJ	CC	_	_	_	_	_
14	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
15	decreased	decrease	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
16	binding	binding	VERB	VBG	VerbForm=Ger	_	_	_	_
17	capacity	capacity	NOUN	NN	Number=Sing	_	_	_	_
18	of	of	ADP	IN	_	_	_	_	_
19	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
20	glucocorticoid	glucocorticoid	ADJ	JJ	Degree=Pos	_	_	_	_
21	receptor	receptor	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
22	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3114
# text = In vitro, hyperthermia as well as variations in the cellular composition did not influence the glucocorticoid receptor.
1	In	in	ADP	IN	_	_	_	_	_
2	vitro	vitro	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
3	,	,	PUNCT	,	_	_	_	_	_
4	hyperthermia	hyperthermia	NOUN	NN	Number=Sing	_	_	_	_
5	as	as	ADV	RB	_	_	_	_	_
6	well	well	ADV	RB	Degree=Pos	_	_	_	_
7	as	as	ADP	IN	_	_	_	_	_
8	variations	variation	NOUN	NNS	Number=Plur	_	_	_	_
9	in	in	ADP	IN	_	_	_	_	_
10	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
11	cellular	cellular	ADJ	JJ	Degree=Pos	_	_	_	_
12	composition	composition	NOUN	NN	Number=Sing	_	_	_	_
13	did	do	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
14	not	not	PART	RB	_	_	_	_	_
15	influence	influence	VERB	VB	VerbForm=Inf	_	_	_	_
16	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
17	glucocorticoid	glucocorticoid	ADJ	JJ	Degree=Pos	_	_	_	_
18	receptor	receptor	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
19	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3115
# text = In vivo, there was no change in the number of receptors per cell in patients with sepsis or septic shock as compared to healthy controls.
1	In	in	ADP	IN	_	_	_	_	_
2	vivo	vivo	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
3	,	,	PUNCT	,	_	_	_	_	_
4	there	there	PRON	EX	_	_	_	_	_
5	was	be	VERB	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
6	no	no	DET	DT	_	_	_	_	_
7	change	change	NOUN	NN	Number=Sing	_	_	_	_
8	in	in	ADP	IN	_	_	_	_	_
9	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
10	number	number	NOUN	NN	Number=Sing	_	_	_	_
11	of	of	ADP	IN	_	_	_	_	_
12	receptors	receptor	NOUN	NNS	Number=Plur	_	_	_	_
13	per	per	ADP	IN	_	_	_	_	_
14	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
15	in	in	ADP	IN	_	_	_	_	_
16	patients	patient	NOUN	NNS	Number=Plur	_	_	_	_
17	with	with	ADP	IN	_	_	_	_	_
18	sepsis	sepsis	NOUN	NN	Number=Sing	_	_	_	_
19	or	or	CCONJ	CC	_	_	_	_	_
20	septic	septic	ADJ	JJ	Degree=Pos	_	_	_	_
21	shock	shock	NOUN	NN	Number=Sing	_	_	_	_
22	as	as	SCONJ	IN	_	_	_	_	_
23	compared	compare	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
24	to	to	ADP	IN	_	_	_	_	_
25	healthy	healthy	ADJ	JJ	Degree=Pos	_	_	_	_
26	controls	control	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
27	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3116
# text = However, a decreased affinity of the glucocorticoid receptor was observed.
1	However	however	ADV	RB	_	_	_	_	SpaceAfter=No
2	,	,	PUNCT	,	_	_	_	_	_
3	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
4	decreased	decrease	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
5	affinity	affinity	NOUN	NN	Number=Sing	_	_	_	_
6	of	of	ADP	IN	_	_	_	_	_
7	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
8	glucocorticoid	glucocorticoid	ADJ	JJ	Degree=Pos	_	_	_	_
9	receptor	receptor	NOUN	NN	Number=Sing	_	_	_	_
10	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
11	observed	observe	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	SpaceAfter=No
12	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3117
# text = There was a weak but significant negative correlation between body temperature and the number of glucocorticoid receptors in the patient group.
1	There	there	PRON	EX	_	_	_	_	_
2	was	be	VERB	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
3	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
4	weak	weak	ADJ	JJ	Degree=Pos	_	_	_	_
5	but	but	CCONJ	CC	_	_	_	_	_
6	significant	significant	ADJ	JJ	Degree=Pos	_	_	_	_
7	negative	negative	ADJ	JJ	Degree=Pos	_	_	_	_
8	correlation	correlation	NOUN	NN	Number=Sing	_	_	_	_
9	between	between	ADP	IN	_	_	_	_	_
10	body	body	NOUN	NN	Number=Sing	_	_	_	_
11	temperature	temperature	NOUN	NN	Number=Sing	_	_	_	_
12	and	and	CCONJ	CC	_	_	_	_	_
13	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
14	number	number	NOUN	NN	Number=Sing	_	_	_	_
15	of	of	ADP	IN	_	_	_	_	_
16	glucocorticoid	glucocorticoid	ADJ	JJ	Degree=Pos	_	_	_	_
17	receptors	receptor	NOUN	NNS	Number=Plur	_	_	_	_
18	in	in	ADP	IN	_	_	_	_	_
19	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
20	patient	patient	NOUN	NN	Number=Sing	_	_	_	_
21	group	group	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
22	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3118
# text = There was no relation between circulating cortisol concentrations and glucocorticoid receptor affinity and number.
1	There	there	PRON	EX	_	_	_	_	_
2	was	be	VERB	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
3	no	no	DET	DT	_	_	_	_	_
4	relation	relation	NOUN	NN	Number=Sing	_	_	_	_
5	between	between	ADP	IN	_	_	_	_	_
6	circulating	circulat	VERB	VBG	VerbForm=Ger	_	_	_	_
7	cortisol	cortisol	NOUN	NN	Number=Sing	_	_	_	_
8	concentrations	concentration	NOUN	NNS	Number=Plur	_	_	_	_
9	and	and	CCONJ	CC	_	_	_	_	_
10	glucocorticoid	glucocorticoid	ADJ	JJ	Degree=Pos	_	_	_	_
11	receptor	receptor	NOUN	NN	Number=Sing	_	_	_	_
12	affinity	affinity	NOUN	NN	Number=Sing	_	_	_	_
13	and	and	CCONJ	CC	_	_	_	_	_
14	number	number	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
15	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3119
# text = CONCLUSIONS:
1	CONCLUSIONS	conclusion	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
2	:	:	PUNCT	:	_	_	_	_	_

# sent_id = 3120
# text = There is no obvious regulation of the number of glucocorticoid receptors by plasma cortisol concentrations in vivo.
1	There	there	PRON	EX	_	_	_	_	_
2	is	be	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
3	no	no	DET	DT	_	_	_	_	_
4	obvious	obvious	ADJ	JJ	Degree=Pos	_	_	_	_
5	regulation	regulation	NOUN	NN	Number=Sing	_	_	_	_
6	of	of	ADP	IN	_	_	_	_	_
7	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
8	number	number	NOUN	NN	Number=Sing	_	_	_	_
9	of	of	ADP	IN	_	_	_	_	_
10	glucocorticoid	glucocorticoid	ADJ	JJ	Degree=Pos	_	_	_	_
11	receptors	receptor	NOUN	NNS	Number=Plur	_	_	_	_
12	by	by	ADP	IN	_	_	_	_	_
13	plasma	plasma	NOUN	NN	Number=Sing	_	_	_	_
14	cortisol	cortisol	NOUN	NN	Number=Sing	_	_	_	_
15	concentrations	concentration	NOUN	NNS	Number=Plur	_	_	_	_
16	in	in	ADP	IN	_	_	_	_	_
17	vivo	vivo	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
18	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3121
# text = The decreased affinity of the glucocorticoid receptor together with the negative correlation between hyperthermia and the number of glucocorticoid receptors in patients with sepsis or septic shock suggest that hypothalamic-pituitary-adrenal axis activation during critical illness is accompanied by peripheral adaptation in glucocorticoid receptor number and affinity.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	decreased	decrease	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
3	affinity	affinity	NOUN	NN	Number=Sing	_	_	_	_
4	of	of	ADP	IN	_	_	_	_	_
5	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
6	glucocorticoid	glucocorticoid	ADJ	JJ	Degree=Pos	_	_	_	_
7	receptor	receptor	NOUN	NN	Number=Sing	_	_	_	_
8	together	together	ADV	RB	_	_	_	_	_
9	with	with	ADP	IN	_	_	_	_	_
10	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
11	negative	negative	ADJ	JJ	Degree=Pos	_	_	_	_
12	correlation	correlation	NOUN	NN	Number=Sing	_	_	_	_
13	between	between	ADP	IN	_	_	_	_	_
14	hyperthermia	hyperthermia	NOUN	NN	Number=Sing	_	_	_	_
15	and	and	CCONJ	CC	_	_	_	_	_
16	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
17	number	number	NOUN	NN	Number=Sing	_	_	_	_
18	of	of	ADP	IN	_	_	_	_	_
19	glucocorticoid	glucocorticoid	ADJ	JJ	Degree=Pos	_	_	_	_
20	receptors	receptor	NOUN	NNS	Number=Plur	_	_	_	_
21	in	in	ADP	IN	_	_	_	_	_
22	patients	patient	NOUN	NNS	Number=Plur	_	_	_	_
23	with	with	ADP	IN	_	_	_	_	_
24	sepsis	sepsis	NOUN	NN	Number=Sing	_	_	_	_
25	or	or	CCONJ	CC	_	_	_	_	_
26	septic	septic	ADJ	JJ	Degree=Pos	_	_	_	_
27	shock	shock	NOUN	NN	Number=Sing	_	_	_	_
28	suggest	suggest	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
29	that	that	SCONJ	IN	_	_	_	_	_
30	hypothalamic	hypothalamic	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
31	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
32	pituitary	pituitary	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
33	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
34	adrenal	adrenal	ADJ	JJ	Degree=Pos	_	_	_	_
35	axis	axis	NOUN	NN	Number=Sing	_	_	_	_
36	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
37	during	during	ADP	IN	_	_	_	_	_
38	critical	critical	ADJ	JJ	Degree=Pos	_	_	_	_
39	illness	illness	NOUN	NN	Number=Sing	_	_	_	_
40	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
41	accompanied	accompany	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
42	by	by	ADP	IN	_	_	_	_	_
43	peripheral	peripheral	ADJ	JJ	Degree=Pos	_	_	_	_
44	adaptation	adaptation	NOUN	NN	Number=Sing	_	_	_	_
45	in	in	ADP	IN	_	_	_	_	_
46	glucocorticoid	glucocorticoid	ADJ	JJ	Degree=Pos	_	_	_	_
47	receptor	receptor	NOUN	NN	Number=Sing	_	_	_	_
48	number	number	NOUN	NN	Number=Sing	_	_	_	_
49	and	and	CCONJ	CC	_	_	_	_	_
50	affinity	affinity	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
51	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 3122
# text = Document 003003388 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	003003388	003003388	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 3123
# text = Bacterial peptidoglycan induces CD14-dependent activation of transcription factors CREB/ATF and AP-1.
1	Bacterial	Bacterial	ADJ	JJ	Degree=Pos	_	_	_	_
2	peptidoglycan	peptidoglycan	ADJ	JJ	Degree=Pos	_	_	_	_
3	induces	induce	NOUN	NNS	Number=Plur	_	_	_	_
4	CD14	CD14	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
5	-	-	PUNCT	:	_	_	_	_	SpaceAfter=No
6	dependent	dependent	ADJ	JJ	Degree=Pos	_	_	_	_
7	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
8	of	of	ADP	IN	_	_	_	_	_
9	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
10	factors	factor	NOUN	NNS	Number=Plur	_	_	_	_
11	CREB	CREB	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
12	/	/	PUNCT	,	_	_	_	_	SpaceAfter=No
13	ATF	ATF	PROPN	NNP	Number=Sing	_	_	_	_
14	and	and	CCONJ	CC	_	_	_	_	_
15	AP	ap	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
16	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
17	1	1	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
18	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 3124
# text = Peptidoglycan (PGN), the major cell wall component of Gram-positive bacteria, induces secretion of cytokines in macrophages through CD14, the pattern recognition receptor that binds lipopolysaccharide and other microbial products.
1	Peptidoglycan	Peptidoglycan	PROPN	NNP	Number=Sing	_	_	_	_
2	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
3	PGN	PGN	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
4	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
5	,	,	PUNCT	,	_	_	_	_	_
6	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
7	major	major	ADJ	JJ	Degree=Pos	_	_	_	_
8	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
9	wall	wall	NOUN	NN	Number=Sing	_	_	_	_
10	component	component	NOUN	NN	Number=Sing	_	_	_	_
11	of	of	ADP	IN	_	_	_	_	_
12	Gram-	Gram-	PUNCT	:	_	_	_	_	SpaceAfter=No
13	positive	positive	ADJ	JJ	Degree=Pos	_	_	_	_
14	bacteria	bacteria	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
15	,	,	PUNCT	,	_	_	_	_	_
16	induces	induce	NOUN	NNS	Number=Plur	_	_	_	_
17	secretion	secretion	NOUN	NN	Number=Sing	_	_	_	_
18	of	of	ADP	IN	_	_	_	_	_
19	cytokines	cytokine	NOUN	NNS	Number=Plur	_	_	_	_
20	in	in	ADP	IN	_	_	_	_	_
21	macrophages	macrophage	NOUN	NNS	Number=Plur	_	_	_	_
22	through	through	ADP	IN	_	_	_	_	_
23	CD14	CD14	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
24	,	,	PUNCT	,	_	_	_	_	_
25	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
26	pattern	pattern	ADJ	JJ	Degree=Pos	_	_	_	_
27	recognition	recognition	NOUN	NN	Number=Sing	_	_	_	_
28	receptor	receptor	NOUN	NN	Number=Sing	_	_	_	_
29	that	that	PRON	WDT	PronType=Rel	_	_	_	_
30	binds	bind	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
31	lipopolysaccharide	lipopolysaccharide	NOUN	NN	Number=Sing	_	_	_	_
32	and	and	CCONJ	CC	_	_	_	_	_
33	other	other	ADJ	JJ	Degree=Pos	_	_	_	_
34	microbial	microbial	ADJ	JJ	Degree=Pos	_	_	_	_
35	products	product	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
36	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3125
# text = To begin to elucidate the mechanisms that regulate the transcription of cytokine genes, we wanted to determine which transcription factors are activated by PGN in mouse RAW264.7 and human THP-1 macrophage cells.
1	To	to	PART	TO	_	_	_	_	_
2	begin	begin	VERB	VB	VerbForm=Inf	_	_	_	_
3	to	to	PART	TO	_	_	_	_	_
4	elucidate	elucidate	VERB	VB	VerbForm=Inf	_	_	_	_
5	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
6	mechanisms	mechanism	NOUN	NNS	Number=Plur	_	_	_	_
7	that	that	PRON	WDT	PronType=Rel	_	_	_	_
8	regulate	regulate	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
9	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
10	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
11	of	of	ADP	IN	_	_	_	_	_
12	cytokine	cytokine	NOUN	NN	Number=Sing	_	_	_	_
13	genes	gene	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
14	,	,	PUNCT	,	_	_	_	_	_
15	we	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
16	wanted	want	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
17	to	to	PART	TO	_	_	_	_	_
18	determine	determine	VERB	VB	VerbForm=Inf	_	_	_	_
19	which	which	DET	WDT	PronType=Int	_	_	_	_
20	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
21	factors	factor	NOUN	NNS	Number=Plur	_	_	_	_
22	are	be	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
23	activated	activate	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
24	by	by	ADP	IN	_	_	_	_	_
25	PGN	Pgn	PROPN	NNP	Number=Sing	_	_	_	_
26	in	in	ADP	IN	_	_	_	_	_
27	mouse	mouse	NOUN	NN	Number=Sing	_	_	_	_
28	RAW	RAW	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
29	264.7	264.7	NUM	CD	NumType=Card	_	_	_	_
30	and	and	CCONJ	CC	_	_	_	_	_
31	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
32	THP	Thp	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
33	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
34	1	1	NUM	CD	NumType=Card	_	_	_	_
35	macrophage	macrophage	NOUN	NN	Number=Sing	_	_	_	_
36	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
37	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3126
# text = Our results demonstrated that: (i) PGN induced phosphorylation of the transcription factors ATF-1 and CREB; (ii) ATF-1 and CREB bound DNA as a dimer and induced transcriptional activation of a CRE reporter plasmid, which was inhibited by dominant negative CREB and ATF-1; (iii) PGN induced phosphorylation of c-Jun, protein synthesis of JunB and c-Fos, and transcriptional activation of the AP-1 reporter plasmid, which was inhibited by dominant negative c-Fos; and (iv) PGN-induced activation of CREB/ATF and AP-1 was mediated through CD14.
1	Our	we	PRON	PRP$	Number=Plur|Person=1|Poss=Yes|PronType=Prs	_	_	_	_
2	results	result	NOUN	NNS	Number=Plur	_	_	_	_
3	demonstrated	demonstrate	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
4	that	that	SCONJ	IN	_	_	_	_	SpaceAfter=No
5	:	:	PUNCT	:	_	_	_	_	_
6	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
7	i	i	X	LS	_	_	_	_	SpaceAfter=No
8	)	)	PUNCT	-RRB-	_	_	_	_	_
9	PGN	Pgn	ADP	IN	_	_	_	_	_
10	induced	induce	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
11	phosphorylation	phosphorylation	NOUN	NN	Number=Sing	_	_	_	_
12	of	of	ADP	IN	_	_	_	_	_
13	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
14	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
15	factors	factor	NOUN	NNS	Number=Plur	_	_	_	_
16	ATF	ATF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
17	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
18	1	1	NUM	CD	NumType=Card	_	_	_	_
19	and	and	CCONJ	CC	_	_	_	_	_
20	CREB	Creb	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
21	;	;	PUNCT	,	_	_	_	_	_
22	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
23	ii	ii	X	LS	_	_	_	_	SpaceAfter=No
24	)	)	PUNCT	-RRB-	_	_	_	_	_
25	ATF	ATF	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
26	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
27	1	1	NUM	CD	NumType=Card	_	_	_	_
28	and	and	CCONJ	CC	_	_	_	_	_
29	CREB	CREB	PROPN	NNP	Number=Sing	_	_	_	_
30	bound	bound	ADJ	JJ	Degree=Pos	_	_	_	_
31	DNA	dna	NOUN	NN	Number=Sing	_	_	_	_
32	as	as	ADP	IN	_	_	_	_	_
33	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
34	dimer	dimer	NOUN	NN	Number=Sing	_	_	_	_
35	and	and	CCONJ	CC	_	_	_	_	_
36	induced	induce	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
37	transcriptional	transcriptional	ADJ	JJ	Degree=Pos	_	_	_	_
38	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
39	of	of	ADP	IN	_	_	_	_	_
40	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
41	CRE	CRE	ADJ	JJ	Degree=Pos	_	_	_	_
42	reporter	reporter	NOUN	NN	Number=Sing	_	_	_	_
43	plasmid	plasmid	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
44	,	,	PUNCT	,	_	_	_	_	_
45	which	which	PRON	WDT	PronType=Rel	_	_	_	_
46	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
47	inhibited	inhibit	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
48	by	by	ADP	IN	_	_	_	_	_
49	dominant	dominant	ADJ	JJ	Degree=Pos	_	_	_	_
50	negative	negative	ADJ	JJ	Degree=Pos	_	_	_	_
51	CREB	Creb	NOUN	NN	Number=Sing	_	_	_	_
52	and	and	CCONJ	CC	_	_	_	_	_
53	ATF	Atf	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
54	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
55	1	1	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
56	;	;	PUNCT	,	_	_	_	_	_
57	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
58	iii	iii	X	LS	_	_	_	_	SpaceAfter=No
59	)	)	PUNCT	-RRB-	_	_	_	_	_
60	PGN	Pgn	ADP	IN	_	_	_	_	_
61	induced	induce	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
62	phosphorylation	phosphorylation	NOUN	NN	Number=Sing	_	_	_	_
63	of	of	ADP	IN	_	_	_	_	_
64	c	c	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
65	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
66	Jun	Jun	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
67	,	,	PUNCT	,	_	_	_	_	_
68	protein	protein	NOUN	NN	Number=Sing	_	_	_	_
69	synthesis	synthesis	NOUN	NN	Number=Sing	_	_	_	_
70	of	of	ADP	IN	_	_	_	_	_
71	JunB	JunB	PROPN	NNP	Number=Sing	_	_	_	_
72	and	and	CCONJ	CC	_	_	_	_	_
73	c-	c-	SYM	NFP	_	_	_	_	SpaceAfter=No
74	Fos	Fo	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
75	,	,	PUNCT	,	_	_	_	_	_
76	and	and	CCONJ	CC	_	_	_	_	_
77	transcriptional	transcriptional	ADJ	JJ	Degree=Pos	_	_	_	_
78	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
79	of	of	ADP	IN	_	_	_	_	_
80	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
81	AP	ap	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
82	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
83	1	1	NUM	CD	NumType=Card	_	_	_	_
84	reporter	reporter	NOUN	NN	Number=Sing	_	_	_	_
85	plasmid	plasmid	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
86	,	,	PUNCT	,	_	_	_	_	_
87	which	which	PRON	WDT	PronType=Rel	_	_	_	_
88	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
89	inhibited	inhibit	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
90	by	by	ADP	IN	_	_	_	_	_
91	dominant	dominant	ADJ	JJ	Degree=Pos	_	_	_	_
92	negative	negative	ADJ	JJ	Degree=Pos	_	_	_	_
93	c-	c-	SYM	NFP	_	_	_	_	SpaceAfter=No
94	Fos	Fos	PROPN	NNPS	Number=Plur	_	_	_	SpaceAfter=No
95	;	;	PUNCT	,	_	_	_	_	_
96	and	and	CCONJ	CC	_	_	_	_	_
97	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
98	iv	iv	X	ADD	_	_	_	_	SpaceAfter=No
99	)	)	PUNCT	-RRB-	_	_	_	_	_
100	PGN	Pgn	ADP	IN	_	_	_	_	SpaceAfter=No
101	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
102	induced	induce	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
103	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
104	of	of	ADP	IN	_	_	_	_	_
105	CREB	CREB	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
106	/	/	PUNCT	,	_	_	_	_	SpaceAfter=No
107	ATF	ATF	PROPN	NNP	Number=Sing	_	_	_	_
108	and	and	CCONJ	CC	_	_	_	_	_
109	AP	Ap	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
110	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
111	1	1	NUM	CD	NumType=Card	_	_	_	_
112	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
113	mediated	mediate	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
114	through	through	ADP	IN	_	_	_	_	_
115	CD	CD	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
116	14	14	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
117	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3127
# text = This is the first study to demonstrate activation of CREB/ATF and AP-1 transcription factors by PGN or by any other component of Gram-positive bacteria.
1	This	this	PRON	DT	Number=Sing|PronType=Dem	_	_	_	_
2	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
3	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
4	first	first	ADJ	JJ	Degree=Pos|NumType=Ord	_	_	_	_
5	study	study	NOUN	NN	Number=Sing	_	_	_	_
6	to	to	PART	TO	_	_	_	_	_
7	demonstrate	demonstrate	VERB	VB	VerbForm=Inf	_	_	_	_
8	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
9	of	of	ADP	IN	_	_	_	_	_
10	CREB	CREB	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
11	/	/	PUNCT	,	_	_	_	_	SpaceAfter=No
12	ATF	ATF	PROPN	NNP	Number=Sing	_	_	_	_
13	and	and	CCONJ	CC	_	_	_	_	_
14	AP	ap	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
15	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
16	1	1	NUM	CD	NumType=Card	_	_	_	_
17	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
18	factors	factor	NOUN	NNS	Number=Plur	_	_	_	_
19	by	by	ADP	IN	_	_	_	_	_
20	PGN	PGN	PROPN	NNP	Number=Sing	_	_	_	_
21	or	or	CCONJ	CC	_	_	_	_	_
22	by	by	ADP	IN	_	_	_	_	_
23	any	any	DET	DT	_	_	_	_	_
24	other	other	ADJ	JJ	Degree=Pos	_	_	_	_
25	component	component	NOUN	NN	Number=Sing	_	_	_	_
26	of	of	ADP	IN	_	_	_	_	_
27	Gram-	Gram-	SYM	NFP	_	_	_	_	SpaceAfter=No
28	positive	positive	ADJ	JJ	Degree=Pos	_	_	_	_
29	bacteria	bacteria	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
30	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 3128
# text = Document 003003389 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	003003389	003003389	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 3129
# text = Nonradioactive quantification of glucocorticoid receptor expression during differentiation of human monocytic cells (U937).
1	Nonradioactive	Nonradioactive	ADJ	JJ	Degree=Pos	_	_	_	_
2	quantification	quantification	NOUN	NN	Number=Sing	_	_	_	_
3	of	of	ADP	IN	_	_	_	_	_
4	glucocorticoid	glucocorticoid	ADJ	JJ	Degree=Pos	_	_	_	_
5	receptor	receptor	NOUN	NN	Number=Sing	_	_	_	_
6	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
7	during	during	ADP	IN	_	_	_	_	_
8	differentiation	differentiation	NOUN	NN	Number=Sing	_	_	_	_
9	of	of	ADP	IN	_	_	_	_	_
10	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
11	monocytic	monocytic	ADJ	JJ	Degree=Pos	_	_	_	_
12	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
13	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
14	U937	U937	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
15	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
16	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 3130
# text = We describe a method for relative quantification of specific mRNA using a nonradioactive assay based on DNA strand competition between identical sequences of biotin- and fluorescein-labeled amplicon (probe) and unlabeled amplicon (target) during hybridization.
1	We	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
2	describe	describe	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
3	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
4	method	method	NOUN	NN	Number=Sing	_	_	_	_
5	for	for	ADP	IN	_	_	_	_	_
6	relative	relative	ADJ	JJ	Degree=Pos	_	_	_	_
7	quantification	quantification	NOUN	NN	Number=Sing	_	_	_	_
8	of	of	ADP	IN	_	_	_	_	_
9	specific	specific	ADJ	JJ	Degree=Pos	_	_	_	_
10	mRNA	mRNa	NOUN	NN	Number=Sing	_	_	_	_
11	using	use	VERB	VBG	VerbForm=Ger	_	_	_	_
12	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
13	nonradioactive	nonradioactive	ADJ	JJ	Degree=Pos	_	_	_	_
14	assay	assay	NOUN	NN	Number=Sing	_	_	_	_
15	based	base	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
16	on	on	ADP	IN	_	_	_	_	_
17	DNA	Dna	NOUN	NN	Number=Sing	_	_	_	_
18	strand	strand	NOUN	NN	Number=Sing	_	_	_	_
19	competition	competition	NOUN	NN	Number=Sing	_	_	_	_
20	between	between	ADP	IN	_	_	_	_	_
21	identical	identical	ADJ	JJ	Degree=Pos	_	_	_	_
22	sequences	sequence	NOUN	NNS	Number=Plur	_	_	_	_
23	of	of	ADP	IN	_	_	_	_	_
24	biotin	biotin	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
25	-	-	PUNCT	,	_	_	_	_	_
26	and	and	CCONJ	CC	_	_	_	_	_
27	fluorescein	fluorescein	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
28	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
29	labeled	label	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
30	amplicon	amplicon	NOUN	NN	Number=Sing	_	_	_	_
31	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
32	probe	probe	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
33	)	)	PUNCT	-RRB-	_	_	_	_	_
34	and	and	CCONJ	CC	_	_	_	_	_
35	unlabeled	unlabel	ADJ	JJ	Degree=Pos	_	_	_	_
36	amplicon	amplicon	NOUN	NN	Number=Sing	_	_	_	_
37	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
38	target	target	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
39	)	)	PUNCT	-RRB-	_	_	_	_	_
40	during	during	ADP	IN	_	_	_	_	_
41	hybridization	hybridization	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
42	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3131
# text = As the target quantity increased, that of the double-labeled probe decreased in accordance with the mass action law.
1	As	as	SCONJ	IN	_	_	_	_	_
2	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
3	target	target	NOUN	NN	Number=Sing	_	_	_	_
4	quantity	quantity	NOUN	NN	Number=Sing	_	_	_	_
5	increased	increase	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	SpaceAfter=No
6	,	,	PUNCT	,	_	_	_	_	_
7	that	that	PRON	DT	Number=Sing|PronType=Dem	_	_	_	_
8	of	of	ADP	IN	_	_	_	_	_
9	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
10	double	double	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
11	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
12	labeled	label	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
13	probe	probe	NOUN	NN	Number=Sing	_	_	_	_
14	decreased	decrease	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
15	in	in	ADP	IN	_	_	_	_	_
16	accordance	accordance	NOUN	NN	Number=Sing	_	_	_	_
17	with	with	ADP	IN	_	_	_	_	_
18	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
19	mass	mass	ADJ	JJ	Degree=Pos	_	_	_	_
20	action	action	NOUN	NN	Number=Sing	_	_	_	_
21	law	law	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
22	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3132
# text = This technique was successfully applied to evaluate differences in glucocorticoid receptor expression in U937 cells before and after the addition of potent differentiation inducers: 12-O-tetradecanoylphorbol 13-acetate (TPA) and a combination of all-trans retinoic acid (RA) and 1,25-dihydroxyvitamin D2 (VD).
1	This	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
2	technique	technique	NOUN	NN	Number=Sing	_	_	_	_
3	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
4	successfully	successfully	ADV	RB	_	_	_	_	_
5	applied	apply	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
6	to	to	PART	TO	_	_	_	_	_
7	evaluate	evaluate	VERB	VB	VerbForm=Inf	_	_	_	_
8	differences	difference	NOUN	NNS	Number=Plur	_	_	_	_
9	in	in	ADP	IN	_	_	_	_	_
10	glucocorticoid	glucocorticoid	ADJ	JJ	Degree=Pos	_	_	_	_
11	receptor	receptor	NOUN	NN	Number=Sing	_	_	_	_
12	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
13	in	in	ADP	IN	_	_	_	_	_
14	U937	U937	NUM	CD	NumType=Card	_	_	_	_
15	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
16	before	before	ADV	RB	_	_	_	_	_
17	and	and	CCONJ	CC	_	_	_	_	_
18	after	after	ADP	IN	_	_	_	_	_
19	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
20	addition	addition	NOUN	NN	Number=Sing	_	_	_	_
21	of	of	ADP	IN	_	_	_	_	_
22	potent	potent	NOUN	NN	Number=Sing	_	_	_	_
23	differentiation	differentiation	NOUN	NN	Number=Sing	_	_	_	_
24	inducers	inducer	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
25	:	:	PUNCT	:	_	_	_	_	_
26	12	12	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
27	-O	-o	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
28	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
29	tetradecanoylphorbol	tetradecanoylphorbol	NOUN	NN	Number=Sing	_	_	_	_
30	13	13	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
31	-	-	PUNCT	:	_	_	_	_	SpaceAfter=No
32	acetate	acetate	NOUN	NN	Number=Sing	_	_	_	_
33	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
34	TPA	TPA	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
35	)	)	PUNCT	-RRB-	_	_	_	_	_
36	and	and	CCONJ	CC	_	_	_	_	_
37	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
38	combination	combination	NOUN	NN	Number=Sing	_	_	_	_
39	of	of	ADP	IN	_	_	_	_	_
40	all	all	DET	DT	_	_	_	_	SpaceAfter=No
41	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
42	trans	tran	NOUN	NNS	Number=Plur	_	_	_	_
43	retinoic	retinoic	ADJ	JJ	Degree=Pos	_	_	_	_
44	acid	acid	NOUN	NN	Number=Sing	_	_	_	_
45	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
46	RA	RA	X	AFX	_	_	_	_	SpaceAfter=No
47	)	)	PUNCT	-RRB-	_	_	_	_	_
48	and	and	CCONJ	CC	_	_	_	_	_
49	1,25	1,25	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
50	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
51	dihydroxyvitamin	dihydroxyvitamin	NOUN	NN	Number=Sing	_	_	_	_
52	D2	d2	NOUN	NN	Number=Sing	_	_	_	_
53	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
54	VD	VD	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
55	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
56	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3133
# text = We observed that TPA treatment was associated with an increase in specific binding of [3H]dexamethasone and up-regulation of GR mRNA while no enhanced GR expression was perceived with RA/VD treatment.
1	We	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
2	observed	observe	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
3	that	that	SCONJ	IN	_	_	_	_	_
4	TPA	TPA	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
5	treatment	treatment	NOUN	NN	Number=Sing	_	_	_	_
6	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
7	associated	associate	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
8	with	with	ADP	IN	_	_	_	_	_
9	an	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
10	increase	increase	NOUN	NN	Number=Sing	_	_	_	_
11	in	in	ADP	IN	_	_	_	_	_
12	specific	specific	ADJ	JJ	Degree=Pos	_	_	_	_
13	binding	binding	NOUN	NN	Number=Sing	_	_	_	_
14	of	of	ADP	IN	_	_	_	_	_
15	[	[	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
16	3	3	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
17	H]	h]	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
18	dexamethasone	dexamethasone	NOUN	NN	Number=Sing	_	_	_	_
19	and	and	CCONJ	CC	_	_	_	_	_
20	up	up	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
21	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
22	regulation	regulation	NOUN	NN	Number=Sing	_	_	_	_
23	of	of	ADP	IN	_	_	_	_	_
24	GR	GR	PROPN	NNP	Number=Sing	_	_	_	_
25	mRNA	mRNA	PROPN	NNP	Number=Sing	_	_	_	_
26	while	while	SCONJ	IN	_	_	_	_	_
27	no	no	DET	DT	_	_	_	_	_
28	enhanced	enhance	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
29	GR	Gr	NOUN	NN	Number=Sing	_	_	_	_
30	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
31	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
32	perceived	perceive	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
33	with	with	ADP	IN	_	_	_	_	_
34	RA	RA	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
35	/	/	PUNCT	,	_	_	_	_	SpaceAfter=No
36	VD	Vd	ADJ	JJ	Degree=Pos	_	_	_	_
37	treatment	treatment	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
38	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 3134
# text = Document 003003390 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	003003390	003003390	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 3135
# text = Alternative polyadenylation events contribute to the induction of NF-ATc in effector T cells.
1	Alternative	alternative	ADJ	JJ	Degree=Pos	_	_	_	_
2	polyadenylation	polyadenylation	NOUN	NN	Number=Sing	_	_	_	_
3	events	event	NOUN	NNS	Number=Plur	_	_	_	_
4	contribute	contribute	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
5	to	to	ADP	IN	_	_	_	_	_
6	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
7	induction	induction	NOUN	NN	Number=Sing	_	_	_	_
8	of	of	ADP	IN	_	_	_	_	_
9	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
10	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
11	ATc	ATc	PROPN	NNP	Number=Sing	_	_	_	_
12	in	in	ADP	IN	_	_	_	_	_
13	effector	effector	NOUN	NN	Number=Sing	_	_	_	_
14	T	t	PROPN	NNP	Number=Sing	_	_	_	_
15	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
16	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 3136
# text = The transcription factor NF-ATc is synthesized in three prominent isoforms.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
3	factor	factor	NOUN	NN	Number=Sing	_	_	_	_
4	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
5	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
6	ATc	ATc	PROPN	NNP	Number=Sing	_	_	_	_
7	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
8	synthesized	synthesize	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
9	in	in	ADP	IN	_	_	_	_	_
10	three	three	NUM	CD	NumType=Card	_	_	_	_
11	prominent	prominent	ADJ	JJ	Degree=Pos	_	_	_	_
12	isoforms	isoform	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
13	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3137
# text = These differ in the length of their C terminal peptides and mode of synthesis.
1	These	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
2	differ	differ	NOUN	NN	Number=Sing	_	_	_	_
3	in	in	ADP	IN	_	_	_	_	_
4	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
5	length	length	NOUN	NN	Number=Sing	_	_	_	_
6	of	of	ADP	IN	_	_	_	_	_
7	their	they	PRON	PRP$	Number=Plur|Person=3|Poss=Yes|PronType=Prs	_	_	_	_
8	C	c	X	GW	_	_	_	_	_
9	terminal	terminal	ADJ	JJ	Degree=Pos	_	_	_	_
10	peptides	peptide	NOUN	NNS	Number=Plur	_	_	_	_
11	and	and	CCONJ	CC	_	_	_	_	_
12	mode	mode	NOUN	NN	Number=Sing	_	_	_	_
13	of	of	ADP	IN	_	_	_	_	_
14	synthesis	synthesis	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
15	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3138
# text = Due to a switch from the use of a 3' polyA site to a more proximal polyA site, NF-ATc expression switches from the synthesis of the two longer isoforms in naive T cells to that of short isoform A in T effector cells.
1	Due	due	ADP	IN	_	_	_	_	_
2	to	to	ADP	IN	_	_	_	_	_
3	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
4	switch	switch	NOUN	NN	Number=Sing	_	_	_	_
5	from	from	ADP	IN	_	_	_	_	_
6	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
7	use	use	NOUN	NN	Number=Sing	_	_	_	_
8	of	of	ADP	IN	_	_	_	_	_
9	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
10	3	3	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
11	'	'	PUNCT	``	_	_	_	_	_
12	polyA	polya	NOUN	NN	Number=Sing	_	_	_	_
13	site	site	NOUN	NN	Number=Sing	_	_	_	_
14	to	to	ADP	IN	_	_	_	_	_
15	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
16	more	more	ADV	RBR	_	_	_	_	_
17	proximal	proximal	ADJ	JJ	Degree=Pos	_	_	_	_
18	polyA	polya	NOUN	NN	Number=Sing	_	_	_	_
19	site	site	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
20	,	,	PUNCT	,	_	_	_	_	_
21	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
22	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
23	ATc	ATc	PROPN	NNP	Number=Sing	_	_	_	_
24	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
25	switches	switche	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
26	from	from	ADP	IN	_	_	_	_	_
27	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
28	synthesis	synthesis	NOUN	NN	Number=Sing	_	_	_	_
29	of	of	ADP	IN	_	_	_	_	_
30	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
31	two	two	NUM	CD	NumType=Card	_	_	_	_
32	longer	longer	ADJ	JJ	Degree=Pos	_	_	_	_
33	isoforms	isoform	NOUN	NNS	Number=Plur	_	_	_	_
34	in	in	ADP	IN	_	_	_	_	_
35	naive	naive	ADJ	JJ	Degree=Pos	_	_	_	_
36	T	t	PROPN	NNP	Number=Sing	_	_	_	_
37	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
38	to	to	ADP	IN	_	_	_	_	_
39	that	that	PRON	DT	Number=Sing|PronType=Dem	_	_	_	_
40	of	of	ADP	IN	_	_	_	_	_
41	short	short	ADJ	JJ	Degree=Pos	_	_	_	_
42	isoform	isoform	NOUN	NN	Number=Sing	_	_	_	_
43	A	a	NOUN	NN	Number=Sing	_	_	_	_
44	in	in	ADP	IN	_	_	_	_	_
45	T	t	PROPN	NNP	Number=Sing	_	_	_	_
46	effector	effector	NOUN	NN	Number=Sing	_	_	_	_
47	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
48	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3139
# text = The relative low binding affinity of cleavage stimulation factor CstF-64 to the proximal polyA site seems to contribute to its neglect in naive T cells.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	relative	relative	ADJ	JJ	Degree=Pos	_	_	_	_
3	low	low	NOUN	NN	Number=Sing	_	_	_	_
4	binding	bind	VERB	VBG	VerbForm=Ger	_	_	_	_
5	affinity	affinity	NOUN	NN	Number=Sing	_	_	_	_
6	of	of	ADP	IN	_	_	_	_	_
7	cleavage	cleavage	NOUN	NN	Number=Sing	_	_	_	_
8	stimulation	stimulation	NOUN	NN	Number=Sing	_	_	_	_
9	factor	factor	NOUN	NN	Number=Sing	_	_	_	_
10	CstF	CstF	ADP	IN	_	_	_	_	SpaceAfter=No
11	-64	-64	NUM	CD	NumType=Card	_	_	_	_
12	to	to	ADP	IN	_	_	_	_	_
13	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
14	proximal	proximal	ADJ	JJ	Degree=Pos	_	_	_	_
15	polyA	polya	NOUN	NN	Number=Sing	_	_	_	_
16	site	site	NOUN	NN	Number=Sing	_	_	_	_
17	seems	seem	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
18	to	to	PART	TO	_	_	_	_	_
19	contribute	contribute	VERB	VB	VerbForm=Inf	_	_	_	_
20	to	to	ADP	IN	_	_	_	_	_
21	its	its	PRON	PRP$	Gender=Neut|Number=Sing|Person=3|Poss=Yes|PronType=Prs	_	_	_	_
22	neglect	neglect	NOUN	NN	Number=Sing	_	_	_	_
23	in	in	ADP	IN	_	_	_	_	_
24	naive	naive	ADJ	JJ	Degree=Pos	_	_	_	_
25	T	t	PROPN	NNP	Number=Sing	_	_	_	_
26	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
27	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3140
# text = These alternative polyadenylation events ensure the rapid accumulation of high concentrations of NF-ATc necessary to exceed critical threshold levels of NF-ATc for gene induction in effector T cells.
1	These	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
2	alternative	alternative	ADJ	JJ	Degree=Pos	_	_	_	_
3	polyadenylation	polyadenylation	NOUN	NN	Number=Sing	_	_	_	_
4	events	event	NOUN	NNS	Number=Plur	_	_	_	_
5	ensure	ensure	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
6	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
7	rapid	rapid	ADJ	JJ	Degree=Pos	_	_	_	_
8	accumulation	accumulation	NOUN	NN	Number=Sing	_	_	_	_
9	of	of	ADP	IN	_	_	_	_	_
10	high	high	ADJ	JJ	Degree=Pos	_	_	_	_
11	concentrations	concentration	NOUN	NNS	Number=Plur	_	_	_	_
12	of	of	ADP	IN	_	_	_	_	_
13	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
14	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
15	ATc	ATc	PROPN	NNP	Number=Sing	_	_	_	_
16	necessary	necessary	ADJ	JJ	Degree=Pos	_	_	_	_
17	to	to	PART	TO	_	_	_	_	_
18	exceed	exceed	VERB	VB	VerbForm=Inf	_	_	_	_
19	critical	critical	ADJ	JJ	Degree=Pos	_	_	_	_
20	threshold	threshold	NOUN	NN	Number=Sing	_	_	_	_
21	levels	level	NOUN	NNS	Number=Plur	_	_	_	_
22	of	of	ADP	IN	_	_	_	_	_
23	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
24	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
25	ATc	ATc	PROPN	NNP	Number=Sing	_	_	_	_
26	for	for	ADP	IN	_	_	_	_	_
27	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
28	induction	induction	NOUN	NN	Number=Sing	_	_	_	_
29	in	in	ADP	IN	_	_	_	_	_
30	effector	effector	NOUN	NN	Number=Sing	_	_	_	_
31	T	t	PROPN	NNP	Number=Sing	_	_	_	_
32	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
33	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 3141
# text = Document 003003392 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	003003392	003003392	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 3142
# text = Direct demonstration of NFATp dephosphorylation and nuclear localization in activated HT-2 cells using a specific NFATp polyclonal antibody.
1	Direct	direct	ADJ	JJ	Degree=Pos	_	_	_	_
2	demonstration	demonstration	NOUN	NN	Number=Sing	_	_	_	_
3	of	of	ADP	IN	_	_	_	_	_
4	NFATp	NFATp	PROPN	NNP	Number=Sing	_	_	_	_
5	dephosphorylation	dephosphorylation	NOUN	NN	Number=Sing	_	_	_	_
6	and	and	CCONJ	CC	_	_	_	_	_
7	nuclear	nuclear	ADJ	JJ	Degree=Pos	_	_	_	_
8	localization	localization	NOUN	NN	Number=Sing	_	_	_	_
9	in	in	ADP	IN	_	_	_	_	_
10	activated	activate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
11	HT	HT	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
12	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
13	2	2	NUM	CD	NumType=Card	_	_	_	_
14	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
15	using	use	VERB	VBG	VerbForm=Ger	_	_	_	_
16	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
17	specific	specific	ADJ	JJ	Degree=Pos	_	_	_	_
18	NFATp	NFATp	PROPN	NNP	Number=Sing	_	_	_	_
19	polyclonal	polyclonal	ADJ	JJ	Degree=Pos	_	_	_	_
20	antibody	antibody	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
21	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 3143
# text = Nuclear factor of activated T cells (NFAT) regulates transcription of a number of cytokine genes, and NFAT DNA binding activity is stimulated following T cell activation.
1	Nuclear	nuclear	ADJ	JJ	Degree=Pos	_	_	_	_
2	factor	factor	NOUN	NN	Number=Sing	_	_	_	_
3	of	of	ADP	IN	_	_	_	_	_
4	activated	activated	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
5	T	T	PROPN	NNP	Number=Sing	_	_	_	_
6	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
7	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
8	NFAT	NFAT	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
9	)	)	PUNCT	-RRB-	_	_	_	_	_
10	regulates	regulate	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
11	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
12	of	of	ADP	IN	_	_	_	_	_
13	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
14	number	number	NOUN	NN	Number=Sing	_	_	_	_
15	of	of	ADP	IN	_	_	_	_	_
16	cytokine	cytokine	NOUN	NN	Number=Sing	_	_	_	_
17	genes	gene	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
18	,	,	PUNCT	,	_	_	_	_	_
19	and	and	CCONJ	CC	_	_	_	_	_
20	NFAT	Nfat	SCONJ	IN	_	_	_	_	_
21	DNA	dna	NOUN	NN	Number=Sing	_	_	_	_
22	binding	binding	VERB	VBG	VerbForm=Ger	_	_	_	_
23	activity	activity	NOUN	NN	Number=Sing	_	_	_	_
24	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
25	stimulated	stimulate	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
26	following	follow	VERB	VBG	VerbForm=Ger	_	_	_	_
27	T	t	PROPN	NNP	Number=Sing	_	_	_	_
28	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
29	activation	activation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
30	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3144
# text = Several lines of evidence have suggested that NFAT is a substrate for calcineurin, a serine/threonine phosphatase.
1	Several	several	ADJ	JJ	Degree=Pos	_	_	_	_
2	lines	line	NOUN	NNS	Number=Plur	_	_	_	_
3	of	of	ADP	IN	_	_	_	_	_
4	evidence	evidence	NOUN	NN	Number=Sing	_	_	_	_
5	have	have	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
6	suggested	suggest	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
7	that	that	SCONJ	IN	_	_	_	_	_
8	NFAT	Nfat	PRON	DT	Number=Sing|PronType=Dem	_	_	_	_
9	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
10	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
11	substrate	substrate	NOUN	NN	Number=Sing	_	_	_	_
12	for	for	ADP	IN	_	_	_	_	_
13	calcineurin	calcineurin	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
14	,	,	PUNCT	,	_	_	_	_	_
15	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
16	serine	serine	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
17	/	/	PUNCT	,	_	_	_	_	SpaceAfter=No
18	threonine	threonine	NUM	CD	NumType=Card	_	_	_	_
19	phosphatase	phosphatase	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
20	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3145
# text = Using a polyclonal antibody to murine NFATp, Western blot analysis of various mouse tissues demonstrated that the 110-130-kDa
1	Using	use	VERB	VBG	VerbForm=Ger	_	_	_	_
2	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
3	polyclonal	polyclonal	ADJ	JJ	Degree=Pos	_	_	_	_
4	antibody	antibody	NOUN	NN	Number=Sing	_	_	_	_
5	to	to	PART	TO	_	_	_	_	_
6	murine	murine	VERB	VB	VerbForm=Inf	_	_	_	_
7	NFATp	NFATp	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
8	,	,	PUNCT	,	_	_	_	_	_
9	Western	western	ADJ	JJ	Degree=Pos	_	_	_	_
10	blot	blot	NOUN	NN	Number=Sing	_	_	_	_
11	analysis	analysis	NOUN	NN	Number=Sing	_	_	_	_
12	of	of	ADP	IN	_	_	_	_	_
13	various	various	ADJ	JJ	Degree=Pos	_	_	_	_
14	mouse	mouse	NOUN	NN	Number=Sing	_	_	_	_
15	tissues	tissue	NOUN	NNS	Number=Plur	_	_	_	_
16	demonstrated	demonstrate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
17	that	that	SCONJ	IN	_	_	_	_	_
18	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
19	110-	110-	SYM	NFP	_	_	_	_	SpaceAfter=No
20	130	130	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
21	-kDa	-kDa	PROPN	NNP	Number=Sing	_	_	_	_

# sent_id = 3146
# text = NFATp protein was highly expressed in thymus and spleen.
1	NFATp	NFATp	ADJ	JJ	Degree=Pos	_	_	_	_
2	protein	protein	NOUN	NN	Number=Sing	_	_	_	_
3	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
4	highly	highly	ADV	RB	_	_	_	_	_
5	expressed	express	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
6	in	in	ADP	IN	_	_	_	_	_
7	thymus	thymus	NOUN	NN	Number=Sing	_	_	_	_
8	and	and	CCONJ	CC	_	_	_	_	_
9	spleen	spleen	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
10	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3147
# text = Treatment of immunoprecipitated NFATp from untreated HT-2 cells with calcineurin resulted in the dephosphorylation of NFATp, demonstrating that NFATp is an in vitro substrate for calcineurin.
1	Treatment	treatment	NOUN	NN	Number=Sing	_	_	_	_
2	of	of	ADP	IN	_	_	_	_	_
3	immunoprecipitated	immunoprecipitate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
4	NFATp	NFATp	NOUN	NN	Number=Sing	_	_	_	_
5	from	from	ADP	IN	_	_	_	_	_
6	untreated	untreated	ADJ	JJ	Degree=Pos	_	_	_	_
7	HT	HT	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
8	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
9	2	2	NUM	CD	NumType=Card	_	_	_	_
10	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
11	with	with	ADP	IN	_	_	_	_	_
12	calcineurin	calcineurin	NOUN	NN	Number=Sing	_	_	_	_
13	resulted	result	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
14	in	in	ADP	IN	_	_	_	_	_
15	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
16	dephosphorylation	dephosphorylation	NOUN	NN	Number=Sing	_	_	_	_
17	of	of	ADP	IN	_	_	_	_	_
18	NFATp	NFATp	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
19	,	,	PUNCT	,	_	_	_	_	_
20	demonstrating	demonstrat	VERB	VBG	VerbForm=Ger	_	_	_	_
21	that	that	SCONJ	IN	_	_	_	_	_
22	NFATp	NFATp	PROPN	NNP	Number=Sing	_	_	_	_
23	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
24	an	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
25	in	in	ADP	IN	_	_	_	_	_
26	vitro	vitro	ADJ	JJ	Degree=Pos	_	_	_	_
27	substrate	substrate	NOUN	NN	Number=Sing	_	_	_	_
28	for	for	ADP	IN	_	_	_	_	_
29	calcineurin	calcineurin	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
30	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3148
# text = NFATp immunoprecipitated from 32P-labeled HT-2 cells migrated as an approximately 120-kDa protein that was localized to the cytosol of the cells.
1	NFATp	NFATp	PROPN	NNP	Number=Sing	_	_	_	_
2	immunoprecipitated	immunoprecipitate	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
3	from	from	ADP	IN	_	_	_	_	_
4	32P	32p	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
5	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
6	labeled	label	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
7	HT	Ht	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
8	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
9	2	2	NUM	CD	NumType=Card	_	_	_	_
10	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
11	migrated	migrate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
12	as	as	ADP	IN	_	_	_	_	_
13	an	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
14	approximately	approximately	ADV	RB	_	_	_	_	_
15	120	120	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
16	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
17	kDa	kDa	NOUN	NN	Number=Sing	_	_	_	_
18	protein	protein	NOUN	NN	Number=Sing	_	_	_	_
19	that	that	PRON	WDT	PronType=Rel	_	_	_	_
20	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
21	localized	localize	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
22	to	to	ADP	IN	_	_	_	_	_
23	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
24	cytosol	cytosol	NOUN	NN	Number=Sing	_	_	_	_
25	of	of	ADP	IN	_	_	_	_	_
26	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
27	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
28	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3149
# text = Treatment of the cells with ionomycin resulted in a decrease in the molecular weight of NFATp and a loss of 32P, consistent with NFATp dephosphorylation.
1	Treatment	treatment	NOUN	NN	Number=Sing	_	_	_	_
2	of	of	ADP	IN	_	_	_	_	_
3	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
4	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
5	with	with	ADP	IN	_	_	_	_	_
6	ionomycin	ionomycin	NOUN	NN	Number=Sing	_	_	_	_
7	resulted	result	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
8	in	in	ADP	IN	_	_	_	_	_
9	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
10	decrease	decrease	NOUN	NN	Number=Sing	_	_	_	_
11	in	in	ADP	IN	_	_	_	_	_
12	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
13	molecular	molecular	ADJ	JJ	Degree=Pos	_	_	_	_
14	weight	weight	NOUN	NN	Number=Sing	_	_	_	_
15	of	of	ADP	IN	_	_	_	_	_
16	NFATp	NFATp	PROPN	NNP	Number=Sing	_	_	_	_
17	and	and	CCONJ	CC	_	_	_	_	_
18	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
19	loss	loss	NOUN	NN	Number=Sing	_	_	_	_
20	of	of	ADP	IN	_	_	_	_	_
21	32	32	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
22	P	p	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
23	,	,	PUNCT	,	_	_	_	_	_
24	consistent	consistent	ADJ	JJ	Degree=Pos	_	_	_	_
25	with	with	ADP	IN	_	_	_	_	_
26	NFATp	NFATp	PROPN	NNP	Number=Sing	_	_	_	_
27	dephosphorylation	dephosphorylation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
28	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3150
# text = The dephosphorylation of NFATp was accompanied by localization of the protein to the nuclear fraction.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	dephosphorylation	dephosphorylation	NOUN	NN	Number=Sing	_	_	_	_
3	of	of	ADP	IN	_	_	_	_	_
4	NFATp	NFATp	PROPN	NNP	Number=Sing	_	_	_	_
5	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
6	accompanied	accompany	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
7	by	by	ADP	IN	_	_	_	_	_
8	localization	localization	NOUN	NN	Number=Sing	_	_	_	_
9	of	of	ADP	IN	_	_	_	_	_
10	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
11	protein	protein	NOUN	NN	Number=Sing	_	_	_	_
12	to	to	ADP	IN	_	_	_	_	_
13	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
14	nuclear	nuclear	ADJ	JJ	Degree=Pos	_	_	_	_
15	fraction	fraction	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
16	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3151
# text = Both of these events were blocked by preincubation of the cells with FK506, a calcineurin inhibitor, consistent with the hypothesis that NFATp is a calcineurin substrate in cells.
1	Both	both	DET	DT	_	_	_	_	_
2	of	of	ADP	IN	_	_	_	_	_
3	these	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
4	events	event	NOUN	NNS	Number=Plur	_	_	_	_
5	were	be	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
6	blocked	block	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
7	by	by	ADP	IN	_	_	_	_	_
8	preincubation	preincubation	NOUN	NN	Number=Sing	_	_	_	_
9	of	of	ADP	IN	_	_	_	_	_
10	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
11	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
12	with	with	ADP	IN	_	_	_	_	_
13	FK506	FK506	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
14	,	,	PUNCT	,	_	_	_	_	_
15	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
16	calcineurin	calcineurin	NOUN	NN	Number=Sing	_	_	_	_
17	inhibitor	inhibitor	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
18	,	,	PUNCT	,	_	_	_	_	_
19	consistent	consistent	ADJ	JJ	Degree=Pos	_	_	_	_
20	with	with	ADP	IN	_	_	_	_	_
21	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
22	hypothesis	hypothesis	NOUN	NN	Number=Sing	_	_	_	_
23	that	that	PRON	WDT	PronType=Rel	_	_	_	_
24	NFATp	NFATp	PROPN	NNP	Number=Sing	_	_	_	_
25	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
26	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
27	calcineurin	calcineurin	NOUN	NN	Number=Sing	_	_	_	_
28	substrate	substrate	NOUN	NN	Number=Sing	_	_	_	_
29	in	in	ADP	IN	_	_	_	_	_
30	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
31	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 3152
# text = Document 003003398 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	003003398	003003398	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 3153
# text = p105 and p98 precursor proteins play an active role in NF-kappa B-mediated signal transduction.
1	p105	p105	NUM	CD	NumType=Card	_	_	_	_
2	and	and	CCONJ	CC	_	_	_	_	_
3	p98	p98	NUM	CD	NumType=Card	_	_	_	_
4	precursor	precursor	ADJ	JJ	Degree=Pos	_	_	_	_
5	proteins	protein	NOUN	NNS	Number=Plur	_	_	_	_
6	play	play	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
7	an	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
8	active	active	ADJ	JJ	Degree=Pos	_	_	_	_
9	role	role	NOUN	NN	Number=Sing	_	_	_	_
10	in	in	ADP	IN	_	_	_	_	_
11	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
12	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
13	kappa	kappa	PROPN	NNP	Number=Sing	_	_	_	_
14	B	b	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
15	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
16	mediated	mediate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
17	signal	signal	NOUN	NN	Number=Sing	_	_	_	_
18	transduction	transduction	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
19	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 3154
# text = The Rel/NF-kappa B family of transcription factors is composed of two distinct subgroups, proteins that undergo proteolytic processing and contain SWI6/ankyrin repeats in their carboxyl termini (p105, p98), and those without such repeats that do not require processing (p65, c-Rel, RelB, and Dorsal).
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	Rel/	rel/	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
3	NF	Nf	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
4	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
5	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_
6	B	b	NOUN	NN	Number=Sing	_	_	_	_
7	family	family	NOUN	NN	Number=Sing	_	_	_	_
8	of	of	ADP	IN	_	_	_	_	_
9	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
10	factors	factor	NOUN	NNS	Number=Plur	_	_	_	_
11	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
12	composed	compose	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
13	of	of	ADP	IN	_	_	_	_	_
14	two	two	NUM	CD	NumType=Card	_	_	_	_
15	distinct	distinct	ADJ	JJ	Degree=Pos	_	_	_	_
16	subgroups	subgroup	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
17	,	,	PUNCT	,	_	_	_	_	_
18	proteins	protein	NOUN	NNS	Number=Plur	_	_	_	_
19	that	that	PRON	WDT	PronType=Rel	_	_	_	_
20	undergo	undergo	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
21	proteolytic	proteolytic	ADJ	JJ	Degree=Pos	_	_	_	_
22	processing	processing	NOUN	NN	Number=Sing	_	_	_	_
23	and	and	CCONJ	CC	_	_	_	_	_
24	contain	contain	VERB	VB	VerbForm=Inf	_	_	_	_
25	SWI6	SWI6	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
26	/	/	PUNCT	,	_	_	_	_	SpaceAfter=No
27	ankyrin	ankyrin	ADP	IN	_	_	_	_	_
28	repeats	repeat	NOUN	NNS	Number=Plur	_	_	_	_
29	in	in	ADP	IN	_	_	_	_	_
30	their	they	PRON	PRP$	Number=Plur|Person=3|Poss=Yes|PronType=Prs	_	_	_	_
31	carboxyl	carboxyl	NOUN	NN	Number=Sing	_	_	_	_
32	termini	termini	NOUN	NN	Number=Sing	_	_	_	_
33	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
34	p105	p105	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
35	,	,	PUNCT	,	_	_	_	_	_
36	p98	p98	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
37	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
38	,	,	PUNCT	,	_	_	_	_	_
39	and	and	CCONJ	CC	_	_	_	_	_
40	those	those	PRON	DT	Number=Plur|PronType=Dem	_	_	_	_
41	without	without	ADP	IN	_	_	_	_	_
42	such	such	ADJ	JJ	Degree=Pos	_	_	_	_
43	repeats	repeat	NOUN	NNS	Number=Plur	_	_	_	_
44	that	that	PRON	WDT	PronType=Rel	_	_	_	_
45	do	do	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
46	not	not	PART	RB	_	_	_	_	_
47	require	require	VERB	VB	VerbForm=Inf	_	_	_	_
48	processing	processing	NOUN	NN	Number=Sing	_	_	_	_
49	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
50	p65	p65	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
51	,	,	PUNCT	,	_	_	_	_	_
52	c	c	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
53	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
54	Rel	Rel	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
55	,	,	PUNCT	,	_	_	_	_	_
56	RelB	Relb	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
57	,	,	PUNCT	,	_	_	_	_	_
58	and	and	CCONJ	CC	_	_	_	_	_
59	Dorsal	Dorsal	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
60	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
61	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3155
# text = We demonstrate that the p105 and p98 precursors share functional properties with the I kappa B proteins, which also contain SWI6/ankyrin repeats.
1	We	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
2	demonstrate	demonstrate	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
3	that	that	SCONJ	IN	_	_	_	_	_
4	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
5	p105	p105	NOUN	NN	Number=Sing	_	_	_	_
6	and	and	CCONJ	CC	_	_	_	_	_
7	p98	p98	NUM	CD	NumType=Card	_	_	_	_
8	precursors	precursor	NOUN	NNS	Number=Plur	_	_	_	_
9	share	share	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
10	functional	functional	ADJ	JJ	Degree=Pos	_	_	_	_
11	properties	property	NOUN	NNS	Number=Plur	_	_	_	_
12	with	with	ADP	IN	_	_	_	_	_
13	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
14	I	I	ADJ	JJ	Degree=Pos	_	_	_	_
15	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_
16	B	b	NOUN	NN	Number=Sing	_	_	_	_
17	proteins	protein	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
18	,	,	PUNCT	,	_	_	_	_	_
19	which	which	PRON	WDT	PronType=Rel	_	_	_	_
20	also	also	ADV	RB	_	_	_	_	_
21	contain	contain	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
22	SWI6	Swi6	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
23	/	/	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
24	ankyrin	ankyrin	NOUN	NN	Number=Sing	_	_	_	_
25	repeats	repeat	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
26	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3156
# text = Both p105 and p98 were found to form stable complexes with other Rel/NF-kappa B family members, including p65 and c-Rel.
1	Both	both	DET	DT	_	_	_	_	_
2	p105	p105	NOUN	NN	Number=Sing	_	_	_	_
3	and	and	CCONJ	CC	_	_	_	_	_
4	p98	p98	NUM	CD	NumType=Card	_	_	_	_
5	were	be	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
6	found	find	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
7	to	to	PART	TO	_	_	_	_	_
8	form	form	VERB	VB	VerbForm=Inf	_	_	_	_
9	stable	stable	ADJ	JJ	Degree=Pos	_	_	_	_
10	complexes	complexe	NOUN	NNS	Number=Plur	_	_	_	_
11	with	with	ADP	IN	_	_	_	_	_
12	other	other	ADJ	JJ	Degree=Pos	_	_	_	_
13	Rel	Rel	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
14	/	/	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
15	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
16	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
17	kappa	kappa	PROPN	NNP	Number=Sing	_	_	_	_
18	B	b	ADJ	JJ	Degree=Pos	_	_	_	_
19	family	family	NOUN	NN	Number=Sing	_	_	_	_
20	members	member	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
21	,	,	PUNCT	,	_	_	_	_	_
22	including	include	VERB	VBG	VerbForm=Ger	_	_	_	_
23	p65	p65	NOUN	NN	Number=Sing	_	_	_	_
24	and	and	CCONJ	CC	_	_	_	_	_
25	c	c	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
26	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
27	Rel	Rel	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
28	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3157
# text = Association with the precursors is sufficient for cytoplasmic retention of either p65 or c-Rel, both of which are otherwise nuclear.
1	Association	Association	NOUN	NN	Number=Sing	_	_	_	_
2	with	with	ADP	IN	_	_	_	_	_
3	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
4	precursors	precursor	NOUN	NNS	Number=Plur	_	_	_	_
5	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
6	sufficient	sufficient	ADJ	JJ	Degree=Pos	_	_	_	_
7	for	for	ADP	IN	_	_	_	_	_
8	cytoplasmic	cytoplasmic	ADJ	JJ	Degree=Pos	_	_	_	_
9	retention	retention	NOUN	NN	Number=Sing	_	_	_	_
10	of	of	ADP	IN	_	_	_	_	_
11	either	either	CCONJ	CC	_	_	_	_	_
12	p65	p65	NOUN	NN	Number=Sing	_	_	_	_
13	or	or	CCONJ	CC	_	_	_	_	_
14	c	c	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
15	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
16	Rel	Rel	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
17	,	,	PUNCT	,	_	_	_	_	_
18	both	both	DET	DT	_	_	_	_	_
19	of	of	ADP	IN	_	_	_	_	_
20	which	which	PRON	WDT	PronType=Rel	_	_	_	_
21	are	be	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
22	otherwise	otherwise	ADV	RB	_	_	_	_	_
23	nuclear	nuclear	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
24	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3158
# text = These complexes undergo stimulus-responsive processing to produce active p50/c-Rel and p55/c-Rel complexes.
1	These	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
2	complexes	complexe	NOUN	NNS	Number=Plur	_	_	_	_
3	undergo	undergo	ADV	RB	_	_	_	_	_
4	stimulus	stimulus	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
5	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
6	responsive	responsive	ADJ	JJ	Degree=Pos	_	_	_	_
7	processing	processing	NOUN	NN	Number=Sing	_	_	_	_
8	to	to	PART	TO	_	_	_	_	_
9	produce	produce	VERB	VB	VerbForm=Inf	_	_	_	_
10	active	active	ADJ	JJ	Degree=Pos	_	_	_	_
11	p50/c	p50/c	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
12	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
13	Rel	Rel	NOUN	NN	Number=Sing	_	_	_	_
14	and	and	CCONJ	CC	_	_	_	_	_
15	p55/c	p55/c	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
16	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
17	Rel	Rel	NOUN	NN	Number=Sing	_	_	_	_
18	complexes	complex	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
19	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3159
# text = These observations suggest a second pathway leading to NF-kappa B induction, in which processing of the precursors rather than phosphorylation of I kappa B plays a major role.
1	These	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
2	observations	observation	NOUN	NNS	Number=Plur	_	_	_	_
3	suggest	suggest	VERB	VB	VerbForm=Inf	_	_	_	_
4	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
5	second	second	ADJ	JJ	Degree=Pos|NumType=Ord	_	_	_	_
6	pathway	pathway	NOUN	NN	Number=Sing	_	_	_	_
7	leading	lead	VERB	VBG	VerbForm=Ger	_	_	_	_
8	to	to	ADP	IN	_	_	_	_	_
9	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
10	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
11	kappa	kappa	PROPN	NNP	Number=Sing	_	_	_	_
12	B	b	PROPN	NNP	Number=Sing	_	_	_	_
13	induction	induction	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
14	,	,	PUNCT	,	_	_	_	_	_
15	in	in	ADP	IN	_	_	_	_	_
16	which	which	PRON	WDT	PronType=Rel	_	_	_	_
17	processing	processing	NOUN	NN	Number=Sing	_	_	_	_
18	of	of	ADP	IN	_	_	_	_	_
19	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
20	precursors	precursor	NOUN	NNS	Number=Plur	_	_	_	_
21	rather	rather	ADV	RB	_	_	_	_	_
22	than	than	ADP	IN	_	_	_	_	_
23	phosphorylation	phosphorylation	NOUN	NN	Number=Sing	_	_	_	_
24	of	of	ADP	IN	_	_	_	_	_
25	I	I	PRON	PRP	Case=Nom|Number=Sing|Person=1|PronType=Prs	_	_	_	_
26	kappa	kappa	PROPN	NNP	Number=Sing	_	_	_	_
27	B	B	PROPN	NNP	Number=Sing	_	_	_	_
28	plays	play	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
29	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
30	major	major	ADJ	JJ	Degree=Pos	_	_	_	_
31	role	role	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
32	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 3160
# text = Document 003003399 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	003003399	003003399	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 3161
# text = IL-10 induces the tyrosine phosphorylation of tyk2 and Jak1 and the differential assembly of STAT1 alpha and STAT3 complexes in human T cells and monocytes.
1	IL	Il	INTJ	UH	_	_	_	_	SpaceAfter=No
2	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
3	10	10	NUM	CD	NumType=Card	_	_	_	_
4	induces	induce	NOUN	NNS	Number=Plur	_	_	_	_
5	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
6	tyrosine	tyrosine	NOUN	NN	Number=Sing	_	_	_	_
7	phosphorylation	phosphorylation	NOUN	NN	Number=Sing	_	_	_	_
8	of	of	ADP	IN	_	_	_	_	_
9	tyk2	tyk2	NUM	CD	NumType=Card	_	_	_	_
10	and	and	CCONJ	CC	_	_	_	_	_
11	Jak1	Jak1	PROPN	NNP	Number=Sing	_	_	_	_
12	and	and	CCONJ	CC	_	_	_	_	_
13	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
14	differential	differential	ADJ	JJ	Degree=Pos	_	_	_	_
15	assembly	assembly	NOUN	NN	Number=Sing	_	_	_	_
16	of	of	ADP	IN	_	_	_	_	_
17	STAT1	STAT1	NUM	CD	NumType=Card	_	_	_	_
18	alpha	alpha	NOUN	NN	Number=Sing	_	_	_	_
19	and	and	CCONJ	CC	_	_	_	_	_
20	STAT3	STAT3	NOUN	NN	Number=Sing	_	_	_	_
21	complexes	complexe	NOUN	NNS	Number=Plur	_	_	_	_
22	in	in	ADP	IN	_	_	_	_	_
23	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
24	T	T	PROPN	NNP	Number=Sing	_	_	_	_
25	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
26	and	and	CCONJ	CC	_	_	_	_	_
27	monocytes	monocyte	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
28	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 3162
# text = IL-10 affects monocytes and T cells by driving the progression of immune responsiveness such that Th2 lymphocyte-mediated effects predominate.
1	IL	Il	INTJ	UH	_	_	_	_	SpaceAfter=No
2	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
3	10	10	NUM	CD	NumType=Card	_	_	_	_
4	affects	affect	NOUN	NNS	Number=Plur	_	_	_	_
5	monocytes	monocyte	NOUN	NNS	Number=Plur	_	_	_	_
6	and	and	CCONJ	CC	_	_	_	_	_
7	T	t	PROPN	NNP	Number=Sing	_	_	_	_
8	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
9	by	by	SCONJ	IN	_	_	_	_	_
10	driving	drive	VERB	VBG	VerbForm=Ger	_	_	_	_
11	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
12	progression	progression	NOUN	NN	Number=Sing	_	_	_	_
13	of	of	ADP	IN	_	_	_	_	_
14	immune	immune	ADJ	JJ	Degree=Pos	_	_	_	_
15	responsiveness	responsiveness	NOUN	NN	Number=Sing	_	_	_	_
16	such	such	ADJ	JJ	Degree=Pos	_	_	_	_
17	that	that	SCONJ	IN	_	_	_	_	_
18	Th2	Th2	NUM	CD	NumType=Card	_	_	_	_
19	lymphocyte	lymphocyte	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
20	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
21	mediated	mediate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
22	effects	effect	NOUN	NNS	Number=Plur	_	_	_	_
23	predominate	predominate	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	SpaceAfter=No
24	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3163
# text = In this report, we show that in monocytes and T cells IL-10 stimulates tyrosine phosphorylation of the signal transducers and activators of transcription, STAT1 alpha and STAT3, in a differential manner such that the relative formation of homo- and heterodimers varies between the two cell types.
1	In	in	ADP	IN	_	_	_	_	_
2	this	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
3	report	report	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
4	,	,	PUNCT	,	_	_	_	_	_
5	we	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
6	show	show	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
7	that	that	SCONJ	IN	_	_	_	_	_
8	in	in	ADP	IN	_	_	_	_	_
9	monocytes	monocyte	NOUN	NNS	Number=Plur	_	_	_	_
10	and	and	CCONJ	CC	_	_	_	_	_
11	T	t	NOUN	NN	Number=Sing	_	_	_	_
12	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
13	IL	Il	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
14	-	-	SYM	SYM	_	_	_	_	SpaceAfter=No
15	10	10	NUM	CD	NumType=Card	_	_	_	_
16	stimulates	stimulate	NOUN	NNS	Number=Plur	_	_	_	_
17	tyrosine	tyrosine	NOUN	NN	Number=Sing	_	_	_	_
18	phosphorylation	phosphorylation	NOUN	NN	Number=Sing	_	_	_	_
19	of	of	ADP	IN	_	_	_	_	_
20	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
21	signal	signal	NOUN	NN	Number=Sing	_	_	_	_
22	transducers	transducer	NOUN	NNS	Number=Plur	_	_	_	_
23	and	and	CCONJ	CC	_	_	_	_	_
24	activators	activator	NOUN	NNS	Number=Plur	_	_	_	_
25	of	of	ADP	IN	_	_	_	_	_
26	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
27	,	,	PUNCT	,	_	_	_	_	_
28	STAT1	STAT1	NUM	CD	NumType=Card	_	_	_	_
29	alpha	alpha	NOUN	NN	Number=Sing	_	_	_	_
30	and	and	CCONJ	CC	_	_	_	_	_
31	STAT3	STAT3	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
32	,	,	PUNCT	,	_	_	_	_	_
33	in	in	ADP	IN	_	_	_	_	_
34	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
35	differential	differential	ADJ	JJ	Degree=Pos	_	_	_	_
36	manner	manner	NOUN	NN	Number=Sing	_	_	_	_
37	such	such	ADJ	JJ	Degree=Pos	_	_	_	_
38	that	that	SCONJ	IN	_	_	_	_	_
39	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
40	relative	relative	ADJ	JJ	Degree=Pos	_	_	_	_
41	formation	formation	NOUN	NN	Number=Sing	_	_	_	_
42	of	of	ADP	IN	_	_	_	_	_
43	homo	homo	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
44	-	-	PUNCT	,	_	_	_	_	_
45	and	and	CCONJ	CC	_	_	_	_	_
46	heterodimers	heterodimer	NOUN	NNS	Number=Plur	_	_	_	_
47	varies	varies	NOUN	NNS	Number=Plur	_	_	_	_
48	between	between	ADP	IN	_	_	_	_	_
49	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
50	two	two	NUM	CD	NumType=Card	_	_	_	_
51	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
52	types	type	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
53	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3164
# text = Moreover, monocytes express a novel IL-10-stimulated STAT protein with an M(r) of 70 kDa that is recognized by the anti-STAT3
1	Moreover	moreover	ADV	RB	_	_	_	_	SpaceAfter=No
2	,	,	PUNCT	,	_	_	_	_	_
3	monocytes	monocyte	NOUN	NNS	Number=Plur	_	_	_	_
4	express	express	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
5	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
6	novel	novel	NOUN	NN	Number=Sing	_	_	_	_
7	IL	Il	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
8	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
9	10	10	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
10	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
11	stimulated	stimulate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
12	STAT	Stat	NOUN	NN	Number=Sing	_	_	_	_
13	protein	protein	NOUN	NN	Number=Sing	_	_	_	_
14	with	with	ADP	IN	_	_	_	_	_
15	an	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
16	M	m	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
17	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
18	r	be	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
19	)	)	PUNCT	-RRB-	_	_	_	_	_
20	of	of	ADP	IN	_	_	_	_	_
21	70	70	NUM	CD	NumType=Card	_	_	_	_
22	kDa	kDa	PROPN	NNP	Number=Sing	_	_	_	_
23	that	that	PRON	WDT	PronType=Rel	_	_	_	_
24	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
25	recognized	recognize	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
26	by	by	ADP	IN	_	_	_	_	_
27	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
28	anti-STAT3	anti-STAT3	NOUN	NN	Number=Sing	_	_	_	_

# sent_id = 3165
# text = Ab but is not observed in T cells.
1	Ab	Ab	PROPN	NNP	Number=Sing	_	_	_	_
2	but	but	CCONJ	CC	_	_	_	_	_
3	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
4	not	not	PART	RB	_	_	_	_	_
5	observed	observe	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
6	in	in	ADP	IN	_	_	_	_	_
7	T	t	PROPN	NNP	Number=Sing	_	_	_	_
8	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
9	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3166
# text = IL-10 treatment of both T cells and monocytes results in the ligand-induced tyrosine phosphorylation of tyk2 and Jak1, but not Jak2 or Jak3.
1	IL	Il	INTJ	UH	_	_	_	_	SpaceAfter=No
2	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
3	10	10	NUM	CD	NumType=Card	_	_	_	_
4	treatment	treatment	NOUN	NN	Number=Sing	_	_	_	_
5	of	of	ADP	IN	_	_	_	_	_
6	both	both	DET	DT	_	_	_	_	_
7	T	t	PROPN	NNP	Number=Sing	_	_	_	_
8	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
9	and	and	CCONJ	CC	_	_	_	_	_
10	monocytes	monocyte	NOUN	NNS	Number=Plur	_	_	_	_
11	results	result	NOUN	NNS	Number=Plur	_	_	_	_
12	in	in	ADP	IN	_	_	_	_	_
13	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
14	ligand	ligand	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
15	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
16	induced	induce	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
17	tyrosine	tyrosine	NOUN	NN	Number=Sing	_	_	_	_
18	phosphorylation	phosphorylation	NOUN	NN	Number=Sing	_	_	_	_
19	of	of	ADP	IN	_	_	_	_	_
20	tyk2	tyk2	NUM	CD	NumType=Card	_	_	_	_
21	and	and	CCONJ	CC	_	_	_	_	_
22	Jak1	Jak1	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
23	,	,	PUNCT	,	_	_	_	_	_
24	but	but	CCONJ	CC	_	_	_	_	_
25	not	not	ADV	RB	_	_	_	_	_
26	Jak2	Jak2	NOUN	NN	Number=Sing	_	_	_	_
27	or	or	CCONJ	CC	_	_	_	_	_
28	Jak3	Jak3	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
29	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3167
# text = Selective modulation of immune responsiveness by IL-10 in cells such as monocytes and T cells may result in part from the differential activation of
1	Selective	selective	ADJ	JJ	Degree=Pos	_	_	_	_
2	modulation	modulation	NOUN	NN	Number=Sing	_	_	_	_
3	of	of	ADP	IN	_	_	_	_	_
4	immune	immune	ADJ	JJ	Degree=Pos	_	_	_	_
5	responsiveness	responsiveness	NOUN	NN	Number=Sing	_	_	_	_
6	by	by	ADP	IN	_	_	_	_	_
7	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
8	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
9	10	10	NUM	CD	NumType=Card	_	_	_	_
10	in	in	ADP	IN	_	_	_	_	_
11	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
12	such	such	ADJ	JJ	Degree=Pos	_	_	_	_
13	as	as	ADP	IN	_	_	_	_	_
14	monocytes	monocyte	NOUN	NNS	Number=Plur	_	_	_	_
15	and	and	CCONJ	CC	_	_	_	_	_
16	T	t	ADJ	JJ	Degree=Pos	_	_	_	_
17	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
18	may	may	AUX	MD	VerbForm=Fin	_	_	_	_
19	result	result	VERB	VB	VerbForm=Inf	_	_	_	_
20	in	in	ADP	IN	_	_	_	_	_
21	part	part	NOUN	NN	Number=Sing	_	_	_	_
22	from	from	ADP	IN	_	_	_	_	_
23	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
24	differential	differential	ADJ	JJ	Degree=Pos	_	_	_	_
25	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
26	of	of	ADP	IN	_	_	_	_	_

# sent_id = 3168
# text = STAT protein pairs.
1	STAT	Stat	ADJ	JJ	Degree=Pos	_	_	_	_
2	protein	protein	NOUN	NN	Number=Sing	_	_	_	_
3	pairs	pair	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 3169
# text = Document 003003405 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	003003405	003003405	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 3170
# text = Impaired binding of a DQ2 and DQ8-binding HSV VP16 peptide to a DQA1*0501/DQB1*0302 trans class II heterodimer.
1	Impaired	Impaired	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
2	binding	binding	VERB	VBG	VerbForm=Ger	_	_	_	_
3	of	of	ADP	IN	_	_	_	_	_
4	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
5	DQ2	Dq2	NOUN	NN	Number=Sing	_	_	_	_
6	and	and	CCONJ	CC	_	_	_	_	_
7	DQ8	Dq8	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
8	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
9	binding	binding	VERB	VBG	VerbForm=Ger	_	_	_	_
10	HSV	Hsv	PROPN	NNP	Number=Sing	_	_	_	_
11	VP	vp	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
12	16	16	NUM	CD	NumType=Card	_	_	_	_
13	peptide	peptide	NOUN	NN	Number=Sing	_	_	_	_
14	to	to	ADP	IN	_	_	_	_	_
15	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
16	DQA1*0501/DQB1*	DQA1*0501/DQB1*	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
17	0302	0302	NUM	CD	NumType=Card	_	_	_	_
18	trans	tran	NOUN	NNS	Number=Plur	_	_	_	_
19	class	class	NOUN	NN	Number=Sing	_	_	_	_
20	II	ii	NUM	CD	NumType=Card	_	_	_	_
21	heterodimer	heterodimer	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
22	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 3171
# text = DQalpha and DQbeta trans heterodimeric HLA-DQ molecules form in individuals heterozygous for the DQ2 and DQ8 specificities.
1	DQalpha	DQalpha	PROPN	NNP	Number=Sing	_	_	_	_
2	and	and	CCONJ	CC	_	_	_	_	_
3	DQbeta	DQbeta	PROPN	NNP	Number=Sing	_	_	_	_
4	trans	tran	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
5	heterodimeric	heterodimeric	ADJ	JJ	Degree=Pos	_	_	_	_
6	HLA	HLa	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
7	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
8	DQ	Dq	NOUN	NN	Number=Sing	_	_	_	_
9	molecules	molecule	NOUN	NNS	Number=Plur	_	_	_	_
10	form	from	NOUN	NN	Number=Sing	_	_	_	_
11	in	in	ADP	IN	_	_	_	_	_
12	individuals	individual	NOUN	NNS	Number=Plur	_	_	_	_
13	heterozygous	heterozygous	ADJ	JJ	Degree=Pos	_	_	_	_
14	for	for	ADP	IN	_	_	_	_	_
15	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
16	DQ2	Dq2	NOUN	NN	Number=Sing	_	_	_	_
17	and	and	CCONJ	CC	_	_	_	_	_
18	DQ8	DQ8	NOUN	NN	Number=Sing	_	_	_	_
19	specificities	specificity	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
20	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3172
# text = Unique functions and disease associations have been postulated for such trans-dimers, which may be different from cis-encoded DQ molecules encoded by the corresponding haplotypes.
1	Unique	unique	ADJ	JJ	Degree=Pos	_	_	_	_
2	functions	function	NOUN	NNS	Number=Plur	_	_	_	_
3	and	and	CCONJ	CC	_	_	_	_	_
4	disease	disease	NOUN	NN	Number=Sing	_	_	_	_
5	associations	association	NOUN	NNS	Number=Plur	_	_	_	_
6	have	have	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
7	been	be	AUX	VBN	Tense=Past|VerbForm=Part	_	_	_	_
8	postulated	postulate	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
9	for	for	ADP	IN	_	_	_	_	_
10	such	such	ADJ	JJ	Degree=Pos	_	_	_	_
11	trans	tran	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
12	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
13	dimers	dimer	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
14	,	,	PUNCT	,	_	_	_	_	_
15	which	which	PRON	WDT	PronType=Rel	_	_	_	_
16	may	may	AUX	MD	VerbForm=Fin	_	_	_	_
17	be	be	AUX	VB	VerbForm=Inf	_	_	_	_
18	different	different	ADJ	JJ	Degree=Pos	_	_	_	_
19	from	from	ADP	IN	_	_	_	_	_
20	cis	cis	DET	DT	Number=Sing|PronType=Dem	_	_	_	SpaceAfter=No
21	-encoded	-encod	ADJ	JJ	Degree=Pos	_	_	_	_
22	DQ	Dq	NOUN	NN	Number=Sing	_	_	_	_
23	molecules	molecule	NOUN	NNS	Number=Plur	_	_	_	_
24	encoded	encod	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
25	by	by	ADP	IN	_	_	_	_	_
26	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
27	corresponding	corresponding	NOUN	NN	Number=Sing	_	_	_	_
28	haplotypes	haplotype	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	SpaceAfter=No
29	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3173
# text = We analyzed the ability of the trans-dimer encoded by HLA-DQA1*0501/DQB1*0302 to bind a peptide antigen which interacts with DQ molecules encoded by both parental haplotypes.
1	We	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
2	analyzed	analyze	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
3	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
4	ability	ability	NOUN	NN	Number=Sing	_	_	_	_
5	of	of	ADP	IN	_	_	_	_	_
6	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
7	trans	tran	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
8	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
9	dimer	dimer	NOUN	NN	Number=Sing	_	_	_	_
10	encoded	encod	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
11	by	by	ADP	IN	_	_	_	_	_
12	HLA	HLA	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
13	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
14	DQA1*0501/DQB	DQA1*0501/DQB	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
15	1*0302	1*0302	NOUN	NN	Number=Sing	_	_	_	_
16	to	to	PART	TO	_	_	_	_	_
17	bind	bind	VERB	VB	VerbForm=Inf	_	_	_	_
18	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
19	peptide	peptide	NOUN	NN	Number=Sing	_	_	_	_
20	antigen	antigen	NOUN	NN	Number=Sing	_	_	_	_
21	which	which	PRON	WDT	PronType=Rel	_	_	_	_
22	interacts	interact	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
23	with	with	ADP	IN	_	_	_	_	_
24	DQ	Dq	PROPN	NNP	Number=Sing	_	_	_	_
25	molecules	molecule	NOUN	NNS	Number=Plur	_	_	_	_
26	encoded	encod	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
27	by	by	ADP	IN	_	_	_	_	_
28	both	both	DET	DT	_	_	_	_	_
29	parental	parental	ADJ	JJ	Degree=Pos	_	_	_	_
30	haplotypes	haplotype	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
31	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3174
# text = Markedly impaired binding was observed, consistent with both the use of different anchor residues and with changes in levels of DQ cis-dimer availability for peptide binding interactions.
1	Markedly	markedly	ADV	RB	_	_	_	_	_
2	impaired	impaire	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
3	binding	bind	VERB	VBG	VerbForm=Ger	_	_	_	_
4	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
5	observed	observe	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
6	,	,	PUNCT	,	_	_	_	_	_
7	consistent	consistent	ADJ	JJ	Degree=Pos	_	_	_	_
8	with	with	ADP	IN	_	_	_	_	_
9	both	both	CCONJ	CC	_	_	_	_	_
10	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
11	use	use	NOUN	NN	Number=Sing	_	_	_	_
12	of	of	ADP	IN	_	_	_	_	_
13	different	different	ADJ	JJ	Degree=Pos	_	_	_	_
14	anchor	anchor	NOUN	NN	Number=Sing	_	_	_	_
15	residues	residue	NOUN	NNS	Number=Plur	_	_	_	_
16	and	and	CCONJ	CC	_	_	_	_	_
17	with	with	ADP	IN	_	_	_	_	_
18	changes	change	NOUN	NNS	Number=Plur	_	_	_	_
19	in	in	ADP	IN	_	_	_	_	_
20	levels	level	NOUN	NNS	Number=Plur	_	_	_	_
21	of	of	ADP	IN	_	_	_	_	_
22	DQ	Dq	NOUN	NN	Number=Sing	_	_	_	_
23	cis-dimer	cis-dimer	NOUN	NN	Number=Sing	_	_	_	_
24	availability	availability	NOUN	NN	Number=Sing	_	_	_	_
25	for	for	ADP	IN	_	_	_	_	_
26	peptide	peptide	NOUN	NN	Number=Sing	_	_	_	_
27	binding	bind	VERB	VBG	VerbForm=Ger	_	_	_	_
28	interactions	interaction	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
29	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 3175
# text = Document 003003411 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	003003411	003003411	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 3176
# text = Constitutive overexpression of the L-selectin gene in fresh leukemic cells of adult T-cell leukemia that can be transactivated by human T-cell lymphotropic virus type 1 Tax.
1	Constitutive	Constitutive	ADJ	JJ	Degree=Pos	_	_	_	_
2	overexpression	overexpression	NOUN	NN	Number=Sing	_	_	_	_
3	of	of	ADP	IN	_	_	_	_	_
4	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
5	L-	L-	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
6	selectin	selectin	NOUN	NN	Number=Sing	_	_	_	_
7	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
8	in	in	ADP	IN	_	_	_	_	_
9	fresh	fresh	ADJ	JJ	Degree=Pos	_	_	_	_
10	leukemic	leukemic	ADJ	JJ	Degree=Pos	_	_	_	_
11	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
12	of	of	ADP	IN	_	_	_	_	_
13	adult	adult	NOUN	NN	Number=Sing	_	_	_	_
14	T-	t-	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
15	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
16	leukemia	leukemia	NOUN	NN	Number=Sing	_	_	_	_
17	that	that	PRON	WDT	PronType=Rel	_	_	_	_
18	can	can	AUX	MD	VerbForm=Fin	_	_	_	_
19	be	be	AUX	VB	VerbForm=Inf	_	_	_	_
20	transactivated	transactivate	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
21	by	by	ADP	IN	_	_	_	_	_
22	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
23	T-	t-	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
24	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
25	lymphotropic	lymphotropic	NOUN	NN	Number=Sing	_	_	_	_
26	virus	virus	NOUN	NN	Number=Sing	_	_	_	_
27	type	type	NOUN	NN	Number=Sing	_	_	_	_
28	1	1	NUM	CD	NumType=Card	_	_	_	_
29	Tax	tax	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
30	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 3177
# text = L-selectin is an adhesion molecule of the selectin family that mediates the initial step of leukocyte adhesion to vascular endothelium.
1	L-	L-	SYM	NFP	_	_	_	_	SpaceAfter=No
2	selectin	selectin	NOUN	NN	Number=Sing	_	_	_	_
3	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
4	an	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
5	adhesion	adhesion	NOUN	NN	Number=Sing	_	_	_	_
6	molecule	molecule	NOUN	NN	Number=Sing	_	_	_	_
7	of	of	ADP	IN	_	_	_	_	_
8	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
9	selectin	selectin	ADJ	JJ	Degree=Pos	_	_	_	_
10	family	family	NOUN	NN	Number=Sing	_	_	_	_
11	that	that	PRON	WDT	PronType=Rel	_	_	_	_
12	mediates	mediate	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
13	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
14	initial	initial	ADJ	JJ	Degree=Pos	_	_	_	_
15	step	step	NOUN	NN	Number=Sing	_	_	_	_
16	of	of	ADP	IN	_	_	_	_	_
17	leukocyte	leukocyte	NOUN	NN	Number=Sing	_	_	_	_
18	adhesion	adhesion	NOUN	NN	Number=Sing	_	_	_	_
19	to	to	ADP	IN	_	_	_	_	_
20	vascular	vascular	ADJ	JJ	Degree=Pos	_	_	_	_
21	endothelium	endothelium	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
22	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3178
# text = Upon cellular activation, expression of the L-selectin gene is downregulated at both the protein and mRNA levels.
1	Upon	upon	ADP	IN	_	_	_	_	_
2	cellular	cellular	ADJ	JJ	Degree=Pos	_	_	_	_
3	activation	activation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
4	,	,	PUNCT	,	_	_	_	_	_
5	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
6	of	of	ADP	IN	_	_	_	_	_
7	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
8	L-	l-	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
9	selectin	selectin	NOUN	NN	Number=Sing	_	_	_	_
10	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
11	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
12	downregulated	downregulate	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
13	at	at	ADP	IN	_	_	_	_	_
14	both	both	CCONJ	CC	_	_	_	_	_
15	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
16	protein	protein	NOUN	NN	Number=Sing	_	_	_	_
17	and	and	CCONJ	CC	_	_	_	_	_
18	mRNA	mRNa	NOUN	NN	Number=Sing	_	_	_	_
19	levels	level	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
20	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3179
# text = To understand the mechanism of leukemic cell infiltration into organs, we studied the expression and regulation of L-selectin mRNA in fresh leukemic cells of adult T-cell leukemia (ATL) patients and investigated the response of the L-selectin promoter to human T-cell lymphotropic virus type 1 (HTLV-1) Tax, which is a viral transcriptional transactivator.
1	To	to	PART	TO	_	_	_	_	_
2	understand	understand	VERB	VB	VerbForm=Inf	_	_	_	_
3	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
4	mechanism	mechanism	NOUN	NN	Number=Sing	_	_	_	_
5	of	of	ADP	IN	_	_	_	_	_
6	leukemic	leukemic	ADJ	JJ	Degree=Pos	_	_	_	_
7	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
8	infiltration	infiltration	NOUN	NN	Number=Sing	_	_	_	_
9	into	into	ADP	IN	_	_	_	_	_
10	organs	organ	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
11	,	,	PUNCT	,	_	_	_	_	_
12	we	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
13	studied	study	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
14	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
15	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
16	and	and	CCONJ	CC	_	_	_	_	_
17	regulation	regulation	NOUN	NN	Number=Sing	_	_	_	_
18	of	of	ADP	IN	_	_	_	_	_
19	L-	L-	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
20	selectin	selectin	NOUN	NN	Number=Sing	_	_	_	_
21	mRNA	mRNa	NOUN	NN	Number=Sing	_	_	_	_
22	in	in	ADP	IN	_	_	_	_	_
23	fresh	fresh	ADJ	JJ	Degree=Pos	_	_	_	_
24	leukemic	leukemic	ADJ	JJ	Degree=Pos	_	_	_	_
25	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
26	of	of	ADP	IN	_	_	_	_	_
27	adult	adult	NOUN	NN	Number=Sing	_	_	_	_
28	T-	t-	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
29	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
30	leukemia	leukemia	NOUN	NN	Number=Sing	_	_	_	_
31	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
32	ATL	ATL	INTJ	UH	_	_	_	_	SpaceAfter=No
33	)	)	PUNCT	-RRB-	_	_	_	_	_
34	patients	patient	NOUN	NNS	Number=Plur	_	_	_	_
35	and	and	CCONJ	CC	_	_	_	_	_
36	investigated	investigate	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
37	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
38	response	response	NOUN	NN	Number=Sing	_	_	_	_
39	of	of	ADP	IN	_	_	_	_	_
40	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
41	L-	l-	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
42	selectin	selectin	NOUN	NN	Number=Sing	_	_	_	_
43	promoter	promoter	NOUN	NN	Number=Sing	_	_	_	_
44	to	to	ADP	IN	_	_	_	_	_
45	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
46	T-	t-	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
47	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
48	lymphotropic	lymphotropic	NOUN	NN	Number=Sing	_	_	_	_
49	virus	virus	NOUN	NN	Number=Sing	_	_	_	_
50	type	type	NOUN	NN	Number=Sing	_	_	_	_
51	1	1	NUM	CD	NumType=Card	_	_	_	_
52	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
53	HTLV	Htlv	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
54	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
55	1	1	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
56	)	)	PUNCT	-RRB-	_	_	_	_	_
57	Tax	tax	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
58	,	,	PUNCT	,	_	_	_	_	_
59	which	which	PRON	WDT	PronType=Rel	_	_	_	_
60	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
61	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
62	viral	viral	ADJ	JJ	Degree=Pos	_	_	_	_
63	transcriptional	transcriptional	ADJ	JJ	Degree=Pos	_	_	_	_
64	transactivator	transactivator	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
65	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3180
# text = Flow cytometry showed that L-selectin was expressed on fresh ATL cells along with other activation antigens.
1	Flow	Flow	ADJ	JJ	Degree=Pos	_	_	_	_
2	cytometry	cytometry	NOUN	NN	Number=Sing	_	_	_	_
3	showed	show	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
4	that	that	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
5	L-	L-	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
6	selectin	selectin	NOUN	NN	Number=Sing	_	_	_	_
7	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
8	expressed	express	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
9	on	on	ADP	IN	_	_	_	_	_
10	fresh	fresh	ADJ	JJ	Degree=Pos	_	_	_	_
11	ATL	Atl	ADJ	JJ	Degree=Pos	_	_	_	_
12	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
13	along	along	ADP	IN	_	_	_	_	_
14	with	with	ADP	IN	_	_	_	_	_
15	other	other	ADJ	JJ	Degree=Pos	_	_	_	_
16	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
17	antigens	antigen	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
18	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3181
# text = Northern blot analysis showed that ATL cells overexpressed that L-selectin mRNA and that the level was aberrantly upregulated after PMA stimulation.
1	Northern	Northern	ADJ	JJ	Degree=Pos	_	_	_	_
2	blot	blot	NOUN	NN	Number=Sing	_	_	_	_
3	analysis	analysis	NOUN	NN	Number=Sing	_	_	_	_
4	showed	show	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
5	that	that	SCONJ	IN	_	_	_	_	_
6	ATL	Atl	PROPN	NNP	Number=Sing	_	_	_	_
7	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
8	overexpressed	overexpress	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
9	that	that	SCONJ	IN	_	_	_	_	_
10	L-	L-	SYM	NFP	_	_	_	_	SpaceAfter=No
11	selectin	selectin	NOUN	NN	Number=Sing	_	_	_	_
12	mRNA	mRNA	NOUN	NN	Number=Sing	_	_	_	_
13	and	and	CCONJ	CC	_	_	_	_	_
14	that	that	SCONJ	IN	_	_	_	_	_
15	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
16	level	level	NOUN	NN	Number=Sing	_	_	_	_
17	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
18	aberrantly	aberrantly	ADV	RB	_	_	_	_	_
19	upregulated	upregulated	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
20	after	after	ADP	IN	_	_	_	_	_
21	PMA	Pma	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
22	stimulation	stimulation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
23	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3182
# text = Studies using in situ hybridization showed expression of the L-selectin mRNA in the infiltrating leukemic cells in the liver of two ATL patients.
1	Studies	study	NOUN	NNS	Number=Plur	_	_	_	_
2	using	use	VERB	VBG	VerbForm=Ger	_	_	_	_
3	in	in	ADP	IN	_	_	_	_	_
4	situ	situ	NOUN	NN	Number=Sing	_	_	_	_
5	hybridization	hybridization	NOUN	NN	Number=Sing	_	_	_	_
6	showed	show	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
7	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
8	of	of	ADP	IN	_	_	_	_	_
9	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
10	L-	l-	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
11	selectin	selectin	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
12	mRNA	mRNA	PROPN	NNP	Number=Sing	_	_	_	_
13	in	in	ADP	IN	_	_	_	_	_
14	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
15	infiltrating	infiltrating	ADJ	JJ	Degree=Pos	_	_	_	_
16	leukemic	leukemic	ADJ	JJ	Degree=Pos	_	_	_	_
17	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
18	in	in	ADP	IN	_	_	_	_	_
19	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
20	liver	liver	NOUN	NN	Number=Sing	_	_	_	_
21	of	of	ADP	IN	_	_	_	_	_
22	two	two	NUM	CD	NumType=Card	_	_	_	_
23	ATL	Atl	ADJ	JJ	Degree=Pos	_	_	_	_
24	patients	patient	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
25	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3183
# text = Intravenous injection of a rat T-cell line that overexpresses L-selectin showed increased organ infiltration.
1	Intravenous	Intravenous	ADJ	JJ	Degree=Pos	_	_	_	_
2	injection	injection	NOUN	NN	Number=Sing	_	_	_	_
3	of	of	ADP	IN	_	_	_	_	_
4	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
5	rat	rat	NOUN	NN	Number=Sing	_	_	_	_
6	T-	T-	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
7	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
8	line	line	NOUN	NN	Number=Sing	_	_	_	_
9	that	that	PRON	WDT	PronType=Rel	_	_	_	_
10	overexpresses	overexpress	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
11	L-	L-	X	GW	_	_	_	_	SpaceAfter=No
12	selectin	selectin	NOUN	NN	Number=Sing	_	_	_	_
13	showed	showed	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
14	increased	increase	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
15	organ	organ	ADJ	JJ	Degree=Pos	_	_	_	_
16	infiltration	infiltration	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
17	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3184
# text = The induction of Tax expression in JPX9 cells resulted in about a twofold increase in the mRNA expression levels compared with the basal level.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	induction	induction	NOUN	NN	Number=Sing	_	_	_	_
3	of	of	ADP	IN	_	_	_	_	_
4	Tax	tax	NOUN	NN	Number=Sing	_	_	_	_
5	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
6	in	in	ADP	IN	_	_	_	_	_
7	JPX9	JPX9	PROPN	NNP	Number=Sing	_	_	_	_
8	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
9	resulted	result	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
10	in	in	ADP	IN	_	_	_	_	_
11	about	about	ADP	IN	_	_	_	_	_
12	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
13	twofold	twofold	NOUN	NN	Number=Sing	_	_	_	_
14	increase	increase	NOUN	NN	Number=Sing	_	_	_	_
15	in	in	ADP	IN	_	_	_	_	_
16	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
17	mRNA	mRNA	PROPN	NNP	Number=Sing	_	_	_	_
18	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
19	levels	level	NOUN	NNS	Number=Plur	_	_	_	_
20	compared	compare	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
21	with	with	ADP	IN	_	_	_	_	_
22	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
23	basal	basal	ADJ	JJ	Degree=Pos	_	_	_	_
24	level	level	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
25	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3185
# text = Chloramphenicol acetyltransferase (CAT) assay after transient cotransfection showed about a fivefold transactivation of the L-selectin promoter by Tax.
1	Chloramphenicol	Chloramphenicol	PROPN	NNP	Number=Sing	_	_	_	_
2	acetyltransferase	acetyltransferase	NOUN	NN	Number=Sing	_	_	_	_
3	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
4	CAT	Cat	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
5	)	)	PUNCT	-RRB-	_	_	_	_	_
6	assay	assay	NOUN	NN	Number=Sing	_	_	_	_
7	after	after	ADP	IN	_	_	_	_	_
8	transient	transient	ADJ	JJ	Degree=Pos	_	_	_	_
9	cotransfection	cotransfection	NOUN	NN	Number=Sing	_	_	_	_
10	showed	show	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
11	about	about	ADP	IN	_	_	_	_	_
12	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
13	fivefold	fivefold	NOUN	NN	Number=Sing	_	_	_	_
14	transactivation	transactivation	NOUN	NN	Number=Sing	_	_	_	_
15	of	of	ADP	IN	_	_	_	_	_
16	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
17	L-	l-	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
18	selectin	selectin	NOUN	NN	Number=Sing	_	_	_	_
19	promoter	promoter	NOUN	NN	Number=Sing	_	_	_	_
20	by	by	ADP	IN	_	_	_	_	_
21	Tax	tax	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
22	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3186
# text = The serum level of the shed form of L-selectin was significantly increased in ATL patients (mean +/- SD, 4,215.4 +/- 4,111 ng/mL) compared with those of asymptomatic carriers and healthy blood donors (mean +/- SD, 1,148.0 +/- 269.0 ng/mL and 991.9 +/- 224 ng/mL, respectively).
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	serum	serum	NOUN	NN	Number=Sing	_	_	_	_
3	level	level	NOUN	NN	Number=Sing	_	_	_	_
4	of	of	ADP	IN	_	_	_	_	_
5	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
6	shed	shed	ADJ	JJ	Degree=Pos	_	_	_	_
7	form	form	NOUN	NN	Number=Sing	_	_	_	_
8	of	of	ADP	IN	_	_	_	_	_
9	L-	L-	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
10	selectin	selectin	NOUN	NN	Number=Sing	_	_	_	_
11	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
12	significantly	significantly	ADV	RB	_	_	_	_	_
13	increased	increase	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
14	in	in	ADP	IN	_	_	_	_	_
15	ATL	Atl	PROPN	NNP	Number=Sing	_	_	_	_
16	patients	patient	NOUN	NNS	Number=Plur	_	_	_	_
17	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
18	mean	mean	X	GW	_	_	_	_	_
19	+/-	+/-	X	GW	_	_	_	_	_
20	SD	sd	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
21	,	,	PUNCT	,	_	_	_	_	_
22	4,215.4	4,215.4	NUM	CD	NumType=Card	_	_	_	_
23	+/-	+/-	SYM	SYM	_	_	_	_	_
24	4,111	4,111	NUM	CD	NumType=Card	_	_	_	_
25	ng	ng	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
26	/	/	PUNCT	,	_	_	_	_	SpaceAfter=No
27	mL	mL	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
28	)	)	PUNCT	-RRB-	_	_	_	_	_
29	compared	compare	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
30	with	with	ADP	IN	_	_	_	_	_
31	those	those	PRON	DT	Number=Plur|PronType=Dem	_	_	_	_
32	of	of	ADP	IN	_	_	_	_	_
33	asymptomatic	asymptomatic	ADJ	JJ	Degree=Pos	_	_	_	_
34	carriers	carrier	NOUN	NNS	Number=Plur	_	_	_	_
35	and	and	CCONJ	CC	_	_	_	_	_
36	healthy	healthy	ADJ	JJ	Degree=Pos	_	_	_	_
37	blood	blood	NOUN	NN	Number=Sing	_	_	_	_
38	donors	donor	NOUN	NNS	Number=Plur	_	_	_	_
39	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
40	mean	mean	X	GW	_	_	_	_	_
41	+/-	+/-	X	GW	_	_	_	_	_
42	SD	SD	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
43	,	,	PUNCT	,	_	_	_	_	_
44	1,148.0	1,148.0	NUM	CD	NumType=Card	_	_	_	_
45	+/-	+/-	SYM	SYM	_	_	_	_	_
46	269.0	269.0	NUM	CD	NumType=Card	_	_	_	_
47	ng/mL	ng/mL	NOUN	NN	Number=Sing	_	_	_	_
48	and	and	CCONJ	CC	_	_	_	_	_
49	991.9	991.9	NUM	CD	NumType=Card	_	_	_	_
50	+/-	+/-	SYM	SYM	_	_	_	_	_
51	224	224	NUM	CD	NumType=Card	_	_	_	_
52	ng	ng	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
53	/	/	PUNCT	,	_	_	_	_	SpaceAfter=No
54	mL	mL	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
55	,	,	PUNCT	,	_	_	_	_	_
56	respectively	respectively	ADV	RB	_	_	_	_	SpaceAfter=No
57	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
58	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3187
# text = These results indicated that ATL cells constitutively overexpress the L-selectin gene that can be transactivated by HTLV-1 Tax.
1	These	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
2	results	result	NOUN	NNS	Number=Plur	_	_	_	_
3	indicated	indicate	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
4	that	that	SCONJ	IN	_	_	_	_	_
5	ATL	Atl	ADJ	JJ	Degree=Pos	_	_	_	_
6	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
7	constitutively	constitutively	ADV	RB	_	_	_	_	_
8	overexpress	overexpress	VERB	VB	VerbForm=Inf	_	_	_	_
9	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
10	L-	l-	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
11	selectin	selectin	NOUN	NN	Number=Sing	_	_	_	_
12	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
13	that	that	PRON	WDT	PronType=Rel	_	_	_	_
14	can	can	AUX	MD	VerbForm=Fin	_	_	_	_
15	be	be	AUX	VB	VerbForm=Inf	_	_	_	_
16	transactivated	transactivate	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
17	by	by	ADP	IN	_	_	_	_	_
18	HTLV	HTLV	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
19	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
20	1	1	NUM	CD	NumType=Card	_	_	_	_
21	Tax	tax	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
22	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3188
# text = The overexpression of L-selectin, as well as of inflammatory cytokines, by ATL cells may provide a basis for ATL cells to attach the vascular endothelium, leading to transmigration and organ infitration.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	overexpression	overexpression	NOUN	NN	Number=Sing	_	_	_	_
3	of	of	ADP	IN	_	_	_	_	_
4	L-	L-	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
5	selectin	selectin	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
6	,	,	PUNCT	,	_	_	_	_	_
7	as	as	ADV	RB	_	_	_	_	_
8	well	well	ADV	RB	Degree=Pos	_	_	_	_
9	as	as	ADP	IN	_	_	_	_	_
10	of	of	ADP	IN	_	_	_	_	_
11	inflammatory	inflammatory	ADJ	JJ	Degree=Pos	_	_	_	_
12	cytokines	cytokine	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
13	,	,	PUNCT	,	_	_	_	_	_
14	by	by	ADP	IN	_	_	_	_	_
15	ATL	Atl	ADJ	JJ	Degree=Pos	_	_	_	_
16	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
17	may	may	AUX	MD	VerbForm=Fin	_	_	_	_
18	provide	provide	VERB	VB	VerbForm=Inf	_	_	_	_
19	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
20	basis	basis	NOUN	NN	Number=Sing	_	_	_	_
21	for	for	ADP	IN	_	_	_	_	_
22	ATL	Atl	ADJ	JJ	Degree=Pos	_	_	_	_
23	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
24	to	to	PART	TO	_	_	_	_	_
25	attach	attach	VERB	VB	VerbForm=Inf	_	_	_	_
26	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
27	vascular	vascular	ADJ	JJ	Degree=Pos	_	_	_	_
28	endothelium	endothelium	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
29	,	,	PUNCT	,	_	_	_	_	_
30	leading	lead	VERB	VBG	VerbForm=Ger	_	_	_	_
31	to	to	ADP	IN	_	_	_	_	_
32	transmigration	transmigration	NOUN	NN	Number=Sing	_	_	_	_
33	and	and	CCONJ	CC	_	_	_	_	_
34	organ	organ	ADJ	JJ	Degree=Pos	_	_	_	_
35	infitration	infitration	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
36	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 3189
# text = Document 003003414 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	003003414	003003414	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 3190
# text = Nonopsonic phagocytosis of Pseudomonas aeruginosa by macrophages and polymorphonuclear leukocytes requires the presence of the bacterial flagellum.
1	Nonopsonic	Nonopsonic	ADJ	JJ	Degree=Pos	_	_	_	_
2	phagocytosis	phagocytosis	NOUN	NN	Number=Sing	_	_	_	_
3	of	of	ADP	IN	_	_	_	_	_
4	Pseudomonas	Pseudomonas	PROPN	NNP	Number=Sing	_	_	_	_
5	aeruginosa	aeruginosa	NOUN	NN	Number=Sing	_	_	_	_
6	by	by	ADP	IN	_	_	_	_	_
7	macrophages	macrophage	NOUN	NNS	Number=Plur	_	_	_	_
8	and	and	CCONJ	CC	_	_	_	_	_
9	polymorphonuclear	polymorphonuclear	ADJ	JJ	Degree=Pos	_	_	_	_
10	leukocytes	leukocyte	NOUN	NNS	Number=Plur	_	_	_	_
11	requires	require	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
12	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
13	presence	presence	NOUN	NN	Number=Sing	_	_	_	_
14	of	of	ADP	IN	_	_	_	_	_
15	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
16	bacterial	bacterial	ADJ	JJ	Degree=Pos	_	_	_	_
17	flagellum	flagellum	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
18	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 3191
# text = Whereas the mechanism of nonopsonic phagocytosis of Pseudomonas aeruginosa has been described, the bacterial ligands required are poorly understood.
1	Whereas	whereas	SCONJ	IN	_	_	_	_	_
2	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
3	mechanism	mechanism	NOUN	NN	Number=Sing	_	_	_	_
4	of	of	ADP	IN	_	_	_	_	_
5	nonopsonic	nonopsonic	ADJ	JJ	Degree=Pos	_	_	_	_
6	phagocytosis	phagocytosis	NOUN	NN	Number=Sing	_	_	_	_
7	of	of	ADP	IN	_	_	_	_	_
8	Pseudomonas	Pseudomonas	PROPN	NNP	Number=Sing	_	_	_	_
9	aeruginosa	aeruginosa	PROPN	NNP	Number=Sing	_	_	_	_
10	has	have	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
11	been	be	AUX	VBN	Tense=Past|VerbForm=Part	_	_	_	_
12	described	describe	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	SpaceAfter=No
13	,	,	PUNCT	,	_	_	_	_	_
14	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
15	bacterial	bacterial	ADJ	JJ	Degree=Pos	_	_	_	_
16	ligands	ligand	NOUN	NNS	Number=Plur	_	_	_	_
17	required	require	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
18	are	be	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
19	poorly	poorly	ADV	RB	_	_	_	_	_
20	understood	understand	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	SpaceAfter=No
21	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3192
# text = To identify the requisite bacterial ligands, studies with isogenic mutants of P. aeruginosa PAK lacking pili, flagella, and the RpoN sigma factor were undertaken.
1	To	to	PART	TO	_	_	_	_	_
2	identify	identify	VERB	VB	VerbForm=Inf	_	_	_	_
3	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
4	requisite	requisite	NOUN	NN	Number=Sing	_	_	_	_
5	bacterial	bacterial	NOUN	NN	Number=Sing	_	_	_	_
6	ligands	ligand	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
7	,	,	PUNCT	,	_	_	_	_	_
8	studies	study	NOUN	NNS	Number=Plur	_	_	_	_
9	with	with	ADP	IN	_	_	_	_	_
10	isogenic	isogenic	ADJ	JJ	Degree=Pos	_	_	_	_
11	mutants	mutant	NOUN	NNS	Number=Plur	_	_	_	_
12	of	of	ADP	IN	_	_	_	_	_
13	P.	P.	NOUN	NN	Number=Sing	_	_	_	_
14	aeruginosa	aeruginosa	NOUN	NN	Number=Sing	_	_	_	_
15	PAK	Pak	NOUN	NN	Number=Sing	_	_	_	_
16	lacking	lack	VERB	VBG	VerbForm=Ger	_	_	_	_
17	pili	pili	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
18	,	,	PUNCT	,	_	_	_	_	_
19	flagella	flagella	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
20	,	,	PUNCT	,	_	_	_	_	_
21	and	and	CCONJ	CC	_	_	_	_	_
22	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
23	RpoN	RpoN	ADJ	JJ	Degree=Pos	_	_	_	_
24	sigma	sigma	NOUN	NN	Number=Sing	_	_	_	_
25	factor	factor	NOUN	NN	Number=Sing	_	_	_	_
26	were	be	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
27	undertaken	undertaken	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
28	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3193
# text = The RpoN mutant, lacking pili, flagella, and nonpilus adhesins, bound poorly and was resistant to ingestion by both macrophages and neutrophils.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	RpoN	RpoN	PROPN	NNP	Number=Sing	_	_	_	_
3	mutant	mutant	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
4	,	,	PUNCT	,	_	_	_	_	_
5	lacking	lack	VERB	VBG	VerbForm=Ger	_	_	_	_
6	pili	pili	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
7	,	,	PUNCT	,	_	_	_	_	_
8	flagella	flagella	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
9	,	,	PUNCT	,	_	_	_	_	_
10	and	and	CCONJ	CC	_	_	_	_	_
11	nonpilus	nonpilus	ADJ	JJ	Degree=Pos	_	_	_	_
12	adhesins	adhesin	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
13	,	,	PUNCT	,	_	_	_	_	_
14	bound	bound	ADJ	JJ	Degree=Pos	_	_	_	_
15	poorly	poorly	ADV	RB	_	_	_	_	_
16	and	and	CCONJ	CC	_	_	_	_	_
17	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
18	resistant	resistant	ADJ	JJ	Degree=Pos	_	_	_	_
19	to	to	PART	TO	_	_	_	_	_
20	ingestion	ingestion	VERB	VB	VerbForm=Inf	_	_	_	_
21	by	by	ADP	IN	_	_	_	_	_
22	both	both	DET	DT	_	_	_	_	_
23	macrophages	macrophage	NOUN	NNS	Number=Plur	_	_	_	_
24	and	and	CCONJ	CC	_	_	_	_	_
25	neutrophils	neutrophil	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
26	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3194
# text = Pili were not absolutely required for binding or phagocytosis of P.
1	Pili	Pili	NOUN	NN	Number=Sing	_	_	_	_
2	were	be	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
3	not	not	PART	RB	_	_	_	_	_
4	absolutely	absolutely	ADV	RB	_	_	_	_	_
5	required	require	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
6	for	for	SCONJ	IN	_	_	_	_	_
7	binding	binding	VERB	VBG	VerbForm=Ger	_	_	_	_
8	or	or	CCONJ	CC	_	_	_	_	_
9	phagocytosis	phagocytosis	NOUN	NN	Number=Sing	_	_	_	_
10	of	of	ADP	IN	_	_	_	_	_
11	P.	P.	PROPN	NNP	Number=Sing	_	_	_	_

# sent_id = 3195
# text = aeruginosa.
1	aeruginosa	aeruginosa	INTJ	UH	_	_	_	_	SpaceAfter=No
2	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3196
# text = The presence of a flagellum was not required for binding of P. aeruginosa to macrophages but was critical for the subsequent internalization of the bacterium, suggesting that this factor or a surface ligand associated with its assembly was responsible for stimulation of nonopsonic phagocytosis.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	presence	presence	NOUN	NN	Number=Sing	_	_	_	_
3	of	of	ADP	IN	_	_	_	_	_
4	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
5	flagellum	flagellum	NOUN	NN	Number=Sing	_	_	_	_
6	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
7	not	not	PART	RB	_	_	_	_	_
8	required	require	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
9	for	for	SCONJ	IN	_	_	_	_	_
10	binding	bind	VERB	VBG	VerbForm=Ger	_	_	_	_
11	of	of	ADP	IN	_	_	_	_	_
12	P.	P.	NOUN	NN	Number=Sing	_	_	_	_
13	aeruginosa	aeruginosa	NOUN	NN	Number=Sing	_	_	_	_
14	to	to	ADP	IN	_	_	_	_	_
15	macrophages	macrophage	NOUN	NNS	Number=Plur	_	_	_	_
16	but	but	CCONJ	CC	_	_	_	_	_
17	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
18	critical	critical	ADJ	JJ	Degree=Pos	_	_	_	_
19	for	for	ADP	IN	_	_	_	_	_
20	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
21	subsequent	subsequent	ADJ	JJ	Degree=Pos	_	_	_	_
22	internalization	internalization	NOUN	NN	Number=Sing	_	_	_	_
23	of	of	ADP	IN	_	_	_	_	_
24	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
25	bacterium	bacterium	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
26	,	,	PUNCT	,	_	_	_	_	_
27	suggesting	suggest	VERB	VBG	VerbForm=Ger	_	_	_	_
28	that	that	SCONJ	IN	_	_	_	_	_
29	this	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
30	factor	factor	NOUN	NN	Number=Sing	_	_	_	_
31	or	or	CCONJ	CC	_	_	_	_	_
32	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
33	surface	surface	NOUN	NN	Number=Sing	_	_	_	_
34	ligand	ligand	NOUN	NN	Number=Sing	_	_	_	_
35	associated	associate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
36	with	with	ADP	IN	_	_	_	_	_
37	its	its	PRON	PRP$	Gender=Neut|Number=Sing|Person=3|Poss=Yes|PronType=Prs	_	_	_	_
38	assembly	assembly	NOUN	NN	Number=Sing	_	_	_	_
39	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
40	responsible	responsible	ADJ	JJ	Degree=Pos	_	_	_	_
41	for	for	ADP	IN	_	_	_	_	_
42	stimulation	stimulation	NOUN	NN	Number=Sing	_	_	_	_
43	of	of	ADP	IN	_	_	_	_	_
44	nonopsonic	nonopsonic	ADJ	JJ	Degree=Pos	_	_	_	_
45	phagocytosis	phagocytosis	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
46	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 3197
# text = Document 003003415 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	003003415	003003415	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 3198
# text = Synergistic interactions between overlapping binding sites for the serum response factor and ELK-1 proteins mediate both basal enhancement and phorbol ester responsiveness of primate cytomegalovirus major immediate-early promoters in monocyte and T-lymphocyte cell types.
1	Synergistic	Synergistic	ADJ	JJ	Degree=Pos	_	_	_	_
2	interactions	interaction	NOUN	NNS	Number=Plur	_	_	_	_
3	between	between	ADP	IN	_	_	_	_	_
4	overlapping	overlapp	NOUN	NN	Number=Sing	_	_	_	_
5	binding	bind	VERB	VBG	VerbForm=Ger	_	_	_	_
6	sites	site	NOUN	NNS	Number=Plur	_	_	_	_
7	for	for	ADP	IN	_	_	_	_	_
8	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
9	serum	serum	NOUN	NN	Number=Sing	_	_	_	_
10	response	response	NOUN	NN	Number=Sing	_	_	_	_
11	factor	factor	NOUN	NN	Number=Sing	_	_	_	_
12	and	and	CCONJ	CC	_	_	_	_	_
13	ELK	elk	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
14	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
15	1	1	NUM	CD	NumType=Card	_	_	_	_
16	proteins	protein	NOUN	NNS	Number=Plur	_	_	_	_
17	mediate	mediate	ADJ	JJ	Degree=Pos	_	_	_	_
18	both	both	CCONJ	CC	_	_	_	_	_
19	basal	basal	ADJ	JJ	Degree=Pos	_	_	_	_
20	enhancement	enhancement	NOUN	NN	Number=Sing	_	_	_	_
21	and	and	CCONJ	CC	_	_	_	_	_
22	phorbol	phorbol	NOUN	NN	Number=Sing	_	_	_	_
23	ester	ester	NOUN	NN	Number=Sing	_	_	_	_
24	responsiveness	responsiveness	NOUN	NN	Number=Sing	_	_	_	_
25	of	of	ADP	IN	_	_	_	_	_
26	primate	primate	ADJ	JJ	Degree=Pos	_	_	_	_
27	cytomegalovirus	cytomegalovirus	NOUN	NN	Number=Sing	_	_	_	_
28	major	major	ADJ	JJ	Degree=Pos	_	_	_	_
29	immediate	immediate	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
30	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
31	early	early	ADJ	JJ	Degree=Pos	_	_	_	_
32	promoters	promoter	NOUN	NNS	Number=Plur	_	_	_	_
33	in	in	ADP	IN	_	_	_	_	_
34	monocyte	monocyte	NOUN	NN	Number=Sing	_	_	_	_
35	and	and	CCONJ	CC	_	_	_	_	_
36	T-	T-	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
37	lymphocyte	lymphocyte	NOUN	NN	Number=Sing	_	_	_	_
38	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
39	types	type	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
40	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 3199
# text = Cytomegalovirus (CMV) infection is nonpermissive or persistent in many lymphoid and myeloid cell types but can be activated in differentiated macrophages.
1	Cytomegalovirus	Cytomegalovirus	PROPN	NNP	Number=Sing	_	_	_	_
2	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
3	CMV	CMV	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
4	)	)	PUNCT	-RRB-	_	_	_	_	_
5	infection	infection	NOUN	NN	Number=Sing	_	_	_	_
6	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
7	nonpermissive	nonpermissive	ADJ	JJ	Degree=Pos	_	_	_	_
8	or	or	CCONJ	CC	_	_	_	_	_
9	persistent	persistent	ADJ	JJ	Degree=Pos	_	_	_	_
10	in	in	ADP	IN	_	_	_	_	_
11	many	many	ADJ	JJ	Degree=Pos	_	_	_	_
12	lymphoid	lymphoid	ADJ	JJ	Degree=Pos	_	_	_	_
13	and	and	CCONJ	CC	_	_	_	_	_
14	myeloid	myeloid	ADJ	JJ	Degree=Pos	_	_	_	_
15	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
16	types	type	NOUN	NNS	Number=Plur	_	_	_	_
17	but	but	CCONJ	CC	_	_	_	_	_
18	can	can	AUX	MD	VerbForm=Fin	_	_	_	_
19	be	be	AUX	VB	VerbForm=Inf	_	_	_	_
20	activated	activate	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
21	in	in	ADP	IN	_	_	_	_	_
22	differentiated	differentiate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
23	macrophages	macrophage	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
24	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3200
# text = We have shown elsewhere that both the major immediate-early gene (MIE) and lytic cycle infectious progeny virus expression can be induced in otherwise nonpermissive monocyte-like U-937 cell cultures infected with either human CMV (HCMV) or simian CMV (SCMV) by treatment with the phorbol ester 12-O-tetradecanoylphorbol-13-acetate (TPA).
1	We	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
2	have	have	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
3	shown	show	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
4	elsewhere	elsewhere	ADV	RB	PronType=Dem	_	_	_	_
5	that	that	SCONJ	IN	_	_	_	_	_
6	both	both	CCONJ	CC	_	_	_	_	_
7	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
8	major	major	ADJ	JJ	Degree=Pos	_	_	_	_
9	immediate	immediate	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
10	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
11	early	early	ADJ	JJ	Degree=Pos	_	_	_	_
12	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
13	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
14	MIE	MIE	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
15	)	)	PUNCT	-RRB-	_	_	_	_	_
16	and	and	CCONJ	CC	_	_	_	_	_
17	lytic	lytic	ADJ	JJ	Degree=Pos	_	_	_	_
18	cycle	cycle	NOUN	NN	Number=Sing	_	_	_	_
19	infectious	infectious	ADJ	JJ	Degree=Pos	_	_	_	_
20	progeny	progeny	NOUN	NN	Number=Sing	_	_	_	_
21	virus	virus	NOUN	NN	Number=Sing	_	_	_	_
22	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
23	can	can	AUX	MD	VerbForm=Fin	_	_	_	_
24	be	be	AUX	VB	VerbForm=Inf	_	_	_	_
25	induced	induce	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
26	in	in	ADP	IN	_	_	_	_	_
27	otherwise	otherwise	ADV	RB	_	_	_	_	_
28	nonpermissive	nonpermissive	ADJ	JJ	Degree=Pos	_	_	_	_
29	monocyte	monocyte	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
30	-like	-like	ADP	IN	_	_	_	_	_
31	U	U	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
32	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
33	937	937	NUM	CD	NumType=Card	_	_	_	_
34	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
35	cultures	culture	NOUN	NNS	Number=Plur	_	_	_	_
36	infected	infect	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
37	with	with	ADP	IN	_	_	_	_	_
38	either	either	DET	DT	_	_	_	_	_
39	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
40	CMV	Cmv	PROPN	NNP	Number=Sing	_	_	_	_
41	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
42	HCMV	HCMV	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
43	)	)	PUNCT	-RRB-	_	_	_	_	_
44	or	or	CCONJ	CC	_	_	_	_	_
45	simian	simian	ADJ	JJ	Degree=Pos	_	_	_	_
46	CMV	CMV	PROPN	NNP	Number=Sing	_	_	_	_
47	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
48	SCMV	SCMV	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
49	)	)	PUNCT	-RRB-	_	_	_	_	_
50	by	by	ADP	IN	_	_	_	_	_
51	treatment	treatment	NOUN	NN	Number=Sing	_	_	_	_
52	with	with	ADP	IN	_	_	_	_	_
53	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
54	phorbol	phorbol	NOUN	NN	Number=Sing	_	_	_	_
55	ester	ester	NOUN	NN	Number=Sing	_	_	_	_
56	12	12	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
57	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
58	O	of	ADP	IN	Abbr=Yes	_	_	_	SpaceAfter=No
59	-tetradecanoylphorbol	-tetradecanoylphorbol	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
60	-13	-13	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
61	-acetate	-acetate	NOUN	NN	Number=Sing	_	_	_	_
62	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
63	TPA	TPA	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
64	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
65	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3201
# text = Two multicopy basal enhancer motifs within the SCMV MIE enhancer, namely, 11 copies of the 16-bp cyclic AMP response element (CRE) and 3 copies of novel 17-bp serum response factor (SRF) binding sites referred to as the SNE (SRF/NFkappaB-like element), as well as four classical NFkappaB sites within the HCMV version, contribute to TPA responsiveness in transient assays in monocyte and T-cell types.
1	Two	two	NUM	CD	NumType=Card	_	_	_	_
2	multicopy	multicopy	ADJ	JJ	Degree=Pos	_	_	_	_
3	basal	basal	ADJ	JJ	Degree=Pos	_	_	_	_
4	enhancer	enhancer	NOUN	NN	Number=Sing	_	_	_	_
5	motifs	motif	NOUN	NNS	Number=Plur	_	_	_	_
6	within	within	ADP	IN	_	_	_	_	_
7	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
8	SCMV	SCMV	PROPN	NNP	Number=Sing	_	_	_	_
9	MIE	MIE	PROPN	NNP	Number=Sing	_	_	_	_
10	enhancer	enhancer	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
11	,	,	PUNCT	,	_	_	_	_	_
12	namely	namely	ADV	RB	_	_	_	_	SpaceAfter=No
13	,	,	PUNCT	,	_	_	_	_	_
14	11	11	NUM	CD	NumType=Card	_	_	_	_
15	copies	copy	NOUN	NNS	Number=Plur	_	_	_	_
16	of	of	ADP	IN	_	_	_	_	_
17	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
18	16	16	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
19	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
20	bp	bp	NOUN	NN	Number=Sing	_	_	_	_
21	cyclic	cyclic	NOUN	NN	Number=Sing	_	_	_	_
22	AMP	Amp	SYM	NFP	_	_	_	_	_
23	response	response	NOUN	NN	Number=Sing	_	_	_	_
24	element	element	NOUN	NN	Number=Sing	_	_	_	_
25	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
26	CRE	CRE	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
27	)	)	PUNCT	-RRB-	_	_	_	_	_
28	and	and	CCONJ	CC	_	_	_	_	_
29	3	3	NUM	CD	NumType=Card	_	_	_	_
30	copies	copy	NOUN	NNS	Number=Plur	_	_	_	_
31	of	of	ADP	IN	_	_	_	_	_
32	novel	novel	NOUN	NN	Number=Sing	_	_	_	_
33	17	17	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
34	-	-	PUNCT	:	_	_	_	_	SpaceAfter=No
35	bp	bp	NOUN	NN	Number=Sing	_	_	_	_
36	serum	serum	NOUN	NN	Number=Sing	_	_	_	_
37	response	response	NOUN	NN	Number=Sing	_	_	_	_
38	factor	factor	NOUN	NN	Number=Sing	_	_	_	_
39	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
40	SRF	SRF	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
41	)	)	PUNCT	-RRB-	_	_	_	_	_
42	binding	bind	VERB	VBG	VerbForm=Ger	_	_	_	_
43	sites	site	NOUN	NNS	Number=Plur	_	_	_	_
44	referred	refer	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
45	to	to	ADP	IN	_	_	_	_	_
46	as	as	ADP	IN	_	_	_	_	_
47	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
48	SNE	SNE	PROPN	NNP	Number=Sing	_	_	_	_
49	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
50	SRF	SRF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
51	/	/	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
52	NFkappaB	NFkappaB	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
53	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
54	like	like	ADJ	JJ	Degree=Pos	_	_	_	_
55	element	element	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
56	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
57	,	,	PUNCT	,	_	_	_	_	_
58	as	as	ADV	RB	_	_	_	_	_
59	well	well	ADV	RB	Degree=Pos	_	_	_	_
60	as	as	ADP	IN	_	_	_	_	_
61	four	four	NUM	CD	NumType=Card	_	_	_	_
62	classical	classical	ADJ	JJ	Degree=Pos	_	_	_	_
63	NFkappaB	Nfkappab	NOUN	NN	Number=Sing	_	_	_	_
64	sites	site	NOUN	NNS	Number=Plur	_	_	_	_
65	within	within	ADP	IN	_	_	_	_	_
66	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
67	HCMV	HCMV	PROPN	NNP	Number=Sing	_	_	_	_
68	version	version	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
69	,	,	PUNCT	,	_	_	_	_	_
70	contribute	contribute	VERB	VB	VerbForm=Inf	_	_	_	_
71	to	to	ADP	IN	_	_	_	_	_
72	TPA	TPA	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
73	responsiveness	responsiveness	NOUN	NN	Number=Sing	_	_	_	_
74	in	in	ADP	IN	_	_	_	_	_
75	transient	transient	ADJ	JJ	Degree=Pos	_	_	_	_
76	assays	assay	NOUN	NNS	Number=Plur	_	_	_	_
77	in	in	ADP	IN	_	_	_	_	_
78	monocyte	monocyte	NOUN	NN	Number=Sing	_	_	_	_
79	and	and	CCONJ	CC	_	_	_	_	_
80	T-	T-	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
81	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
82	types	type	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
83	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3202
# text = The SCMV SNE sites contain potential overlapping core recognition binding motifs for SRF, Rel/NFkappaB, ETS, and YY1 class transcription factors but fail to respond to either serum or tumor necrosis factor alpha.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	SCMV	SCMV	PROPN	NNP	Number=Sing	_	_	_	_
3	SNE	SNE	PROPN	NNP	Number=Sing	_	_	_	_
4	sites	site	NOUN	NNS	Number=Plur	_	_	_	_
5	contain	contain	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
6	potential	potential	ADJ	JJ	Degree=Pos	_	_	_	_
7	overlapping	overlapp	NOUN	NN	Number=Sing	_	_	_	_
8	core	core	NOUN	NN	Number=Sing	_	_	_	_
9	recognition	recognition	NOUN	NN	Number=Sing	_	_	_	_
10	binding	bind	VERB	VBG	VerbForm=Ger	_	_	_	_
11	motifs	motif	NOUN	NNS	Number=Plur	_	_	_	_
12	for	for	ADP	IN	_	_	_	_	_
13	SRF	SRF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
14	,	,	PUNCT	,	_	_	_	_	_
15	Rel/	Rel/	ADP	IN	Abbr=Yes	_	_	_	SpaceAfter=No
16	NFkappaB	NFkappaB	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
17	,	,	PUNCT	,	_	_	_	_	_
18	ETS	Ets	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
19	,	,	PUNCT	,	_	_	_	_	_
20	and	and	CCONJ	CC	_	_	_	_	_
21	YY1	YY1	NUM	CD	NumType=Card	_	_	_	_
22	class	class	NOUN	NN	Number=Sing	_	_	_	_
23	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
24	factors	factor	NOUN	NNS	Number=Plur	_	_	_	_
25	but	but	CCONJ	CC	_	_	_	_	_
26	fail	fail	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
27	to	to	PART	TO	_	_	_	_	_
28	respond	respond	VERB	VB	VerbForm=Inf	_	_	_	_
29	to	to	ADP	IN	_	_	_	_	_
30	either	either	CCONJ	CC	_	_	_	_	_
31	serum	serum	NOUN	NN	Number=Sing	_	_	_	_
32	or	or	CCONJ	CC	_	_	_	_	_
33	tumor	tumor	NOUN	NN	Number=Sing	_	_	_	_
34	necrosis	necrosis	NOUN	NN	Number=Sing	_	_	_	_
35	factor	factor	NOUN	NN	Number=Sing	_	_	_	_
36	alpha	alpha	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
37	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3203
# text = Therefore, to evaluate the mechanism of TPA responsiveness of the SNE motifs and of a related 16-bp SEE (SRF/ETS element) motif found in the HCMV and chimpanzee CMV MIE enhancers, we have examined the functional responses and protein binding properties of multimerized wild-type and mutant elements added upstream to the SCMV MIE or simian virus 40 minimal promoter regions in the U-937, K-562, HL-60, THP-1, and Jurkat cell lines.
1	Therefore	therefore	ADV	RB	_	_	_	_	SpaceAfter=No
2	,	,	PUNCT	,	_	_	_	_	_
3	to	to	PART	TO	_	_	_	_	_
4	evaluate	evaluate	VERB	VB	VerbForm=Inf	_	_	_	_
5	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
6	mechanism	mechanism	NOUN	NN	Number=Sing	_	_	_	_
7	of	of	ADP	IN	_	_	_	_	_
8	TPA	TPa	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
9	responsiveness	responsiveness	NOUN	NN	Number=Sing	_	_	_	_
10	of	of	ADP	IN	_	_	_	_	_
11	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
12	SNE	Sne	ADJ	JJ	Degree=Pos	_	_	_	_
13	motifs	motif	NOUN	NNS	Number=Plur	_	_	_	_
14	and	and	CCONJ	CC	_	_	_	_	_
15	of	of	ADP	IN	_	_	_	_	_
16	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
17	related	relate	ADJ	JJ	Degree=Pos	_	_	_	_
18	16	16	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
19	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
20	bp	bp	NOUN	NN	Number=Sing	_	_	_	_
21	SEE	See	NOUN	NN	Number=Sing	_	_	_	_
22	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
23	SRF	SRF	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
24	/	/	PUNCT	,	_	_	_	_	SpaceAfter=No
25	ETS	Ets	NOUN	NN	Number=Sing	_	_	_	_
26	element	element	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
27	)	)	PUNCT	-RRB-	_	_	_	_	_
28	motif	motif	NOUN	NN	Number=Sing	_	_	_	_
29	found	find	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
30	in	in	ADP	IN	_	_	_	_	_
31	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
32	HCMV	HCMV	PROPN	NNP	Number=Sing	_	_	_	_
33	and	and	CCONJ	CC	_	_	_	_	_
34	chimpanzee	chimpanzee	PROPN	NNP	Number=Sing	_	_	_	_
35	CMV	CMV	PROPN	NNP	Number=Sing	_	_	_	_
36	MIE	MIE	PROPN	NNP	Number=Sing	_	_	_	_
37	enhancers	enhancer	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
38	,	,	PUNCT	,	_	_	_	_	_
39	we	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
40	have	have	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
41	examined	examine	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
42	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
43	functional	functional	ADJ	JJ	Degree=Pos	_	_	_	_
44	responses	response	NOUN	NNS	Number=Plur	_	_	_	_
45	and	and	CCONJ	CC	_	_	_	_	_
46	protein	protein	VERB	VB	VerbForm=Inf	_	_	_	_
47	binding	bind	VERB	VBG	VerbForm=Ger	_	_	_	_
48	properties	property	NOUN	NNS	Number=Plur	_	_	_	_
49	of	of	ADP	IN	_	_	_	_	_
50	multimerized	multimerize	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
51	wild	wild	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
52	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
53	type	type	NOUN	NN	Number=Sing	_	_	_	_
54	and	and	CCONJ	CC	_	_	_	_	_
55	mutant	mutant	ADJ	JJ	Degree=Pos	_	_	_	_
56	elements	element	NOUN	NNS	Number=Plur	_	_	_	_
57	added	add	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
58	upstream	upstream	ADJ	JJ	Degree=Pos	_	_	_	_
59	to	to	ADP	IN	_	_	_	_	_
60	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
61	SCMV	SCMV	PROPN	NNP	Number=Sing	_	_	_	_
62	MIE	MIE	PROPN	NNP	Number=Sing	_	_	_	_
63	or	or	CCONJ	CC	_	_	_	_	_
64	simian	simian	ADJ	JJ	Degree=Pos	_	_	_	_
65	virus	virus	NOUN	NN	Number=Sing	_	_	_	_
66	40	40	NUM	CD	NumType=Card	_	_	_	_
67	minimal	minimal	ADJ	JJ	Degree=Pos	_	_	_	_
68	promoter	promoter	NOUN	NN	Number=Sing	_	_	_	_
69	regions	region	NOUN	NNS	Number=Plur	_	_	_	_
70	in	in	ADP	IN	_	_	_	_	_
71	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
72	U-	u-	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
73	937	937	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
74	,	,	PUNCT	,	_	_	_	_	_
75	K	k	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
76	-	-	SYM	SYM	_	_	_	_	SpaceAfter=No
77	562	562	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
78	,	,	PUNCT	,	_	_	_	_	_
79	HL	HL	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
80	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
81	60	60	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
82	,	,	PUNCT	,	_	_	_	_	_
83	THP	Thp	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
84	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
85	1	1	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
86	,	,	PUNCT	,	_	_	_	_	_
87	and	and	CCONJ	CC	_	_	_	_	_
88	Jurkat	Jurkat	PROPN	NNP	Number=Sing	_	_	_	_
89	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
90	lines	line	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
91	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3204
# text = Unlike classical NFkappaB sites, neither the SNE nor the SEE motif responded to phosphatase inhibition by okadaic acid.
1	Unlike	unlike	ADP	IN	_	_	_	_	_
2	classical	classical	ADJ	JJ	Degree=Pos	_	_	_	_
3	NFkappaB	Nfkappab	NOUN	NN	Number=Sing	_	_	_	_
4	sites	site	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
5	,	,	PUNCT	,	_	_	_	_	_
6	neither	neither	CCONJ	CC	_	_	_	_	_
7	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
8	SNE	Sne	NOUN	NN	Number=Sing	_	_	_	_
9	nor	nor	CCONJ	CC	_	_	_	_	_
10	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
11	SEE	see	ADJ	JJ	Degree=Pos	_	_	_	_
12	motif	motif	NOUN	NN	Number=Sing	_	_	_	_
13	responded	respond	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
14	to	to	PART	TO	_	_	_	_	_
15	phosphatase	phosphatase	VERB	VB	VerbForm=Inf	_	_	_	_
16	inhibition	inhibition	NOUN	NN	Number=Sing	_	_	_	_
17	by	by	ADP	IN	_	_	_	_	_
18	okadaic	okadaic	ADJ	JJ	Degree=Pos	_	_	_	_
19	acid	acid	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
20	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3205
# text = However, the TPA responsiveness of both CMV elements proved to involve synergistic interactions between the core SRF binding site (CCATATATGG) and the adjacent inverted ETS binding motifs (TTCC), which correlated directly with formation of a bound tripartite complex containing both the cellular SRF and ELK-1 proteins.
1	However	however	ADV	RB	_	_	_	_	SpaceAfter=No
2	,	,	PUNCT	,	_	_	_	_	_
3	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
4	TPA	TPA	PROPN	NNP	Number=Sing	_	_	_	_
5	responsiveness	responsiveness	NOUN	NN	Number=Sing	_	_	_	_
6	of	of	ADP	IN	_	_	_	_	_
7	both	both	DET	DT	_	_	_	_	_
8	CMV	CMV	PROPN	NNP	Number=Sing	_	_	_	_
9	elements	element	NOUN	NNS	Number=Plur	_	_	_	_
10	proved	prove	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
11	to	to	PART	TO	_	_	_	_	_
12	involve	involve	VERB	VB	VerbForm=Inf	_	_	_	_
13	synergistic	synergistic	ADJ	JJ	Degree=Pos	_	_	_	_
14	interactions	interaction	NOUN	NNS	Number=Plur	_	_	_	_
15	between	between	ADP	IN	_	_	_	_	_
16	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
17	core	core	NOUN	NN	Number=Sing	_	_	_	_
18	SRF	Srf	SCONJ	IN	_	_	_	_	_
19	binding	bind	VERB	VBG	VerbForm=Ger	_	_	_	_
20	site	site	NOUN	NN	Number=Sing	_	_	_	_
21	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
22	CCATATATGG	CCATATATGG	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
23	)	)	PUNCT	-RRB-	_	_	_	_	_
24	and	and	CCONJ	CC	_	_	_	_	_
25	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
26	adjacent	adjacent	ADJ	JJ	Degree=Pos	_	_	_	_
27	inverted	invert	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
28	ETS	ets	NOUN	NNS	Number=Plur	_	_	_	_
29	binding	binding	VERB	VBG	VerbForm=Ger	_	_	_	_
30	motifs	motif	NOUN	NNS	Number=Plur	_	_	_	_
31	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
32	TTCC	TTCC	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
33	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
34	,	,	PUNCT	,	_	_	_	_	_
35	which	which	PRON	WDT	PronType=Rel	_	_	_	_
36	correlated	correlate	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
37	directly	directly	ADV	RB	_	_	_	_	_
38	with	with	ADP	IN	_	_	_	_	_
39	formation	formation	NOUN	NN	Number=Sing	_	_	_	_
40	of	of	ADP	IN	_	_	_	_	_
41	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
42	bound	bound	ADJ	JJ	Degree=Pos	_	_	_	_
43	tripartite	tripartite	ADJ	JJ	Degree=Pos	_	_	_	_
44	complex	complex	NOUN	NN	Number=Sing	_	_	_	_
45	containing	contain	VERB	VBG	VerbForm=Ger	_	_	_	_
46	both	both	CCONJ	CC	_	_	_	_	_
47	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
48	cellular	cellular	ADJ	JJ	Degree=Pos	_	_	_	_
49	SRF	SRF	PROPN	NNP	Number=Sing	_	_	_	_
50	and	and	CCONJ	CC	_	_	_	_	_
51	ELK	elk	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
52	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
53	1	1	NUM	CD	NumType=Card	_	_	_	_
54	proteins	protein	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
55	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3206
# text = This protein complex was more abundant in U-937, K-562, and HeLa cell extracts than in Raji, HF, BALB/c 3T3, or HL-60 cells, but the binding activity was altered only twofold after TPA treatment.
1	This	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
2	protein	protein	NOUN	NN	Number=Sing	_	_	_	_
3	complex	complex	NOUN	NN	Number=Sing	_	_	_	_
4	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
5	more	more	ADV	RBR	_	_	_	_	_
6	abundant	abundant	ADJ	JJ	Degree=Pos	_	_	_	_
7	in	in	ADP	IN	_	_	_	_	_
8	U	U	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
9	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
10	937	937	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
11	,	,	PUNCT	,	_	_	_	_	_
12	K	k	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
13	-	-	SYM	SYM	_	_	_	_	SpaceAfter=No
14	562	562	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
15	,	,	PUNCT	,	_	_	_	_	_
16	and	and	CCONJ	CC	_	_	_	_	_
17	HeLa	HeLa	PROPN	NNP	Number=Sing	_	_	_	_
18	cell	cell	PROPN	NNP	Number=Sing	_	_	_	_
19	extracts	extract	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
20	than	than	ADP	IN	_	_	_	_	_
21	in	in	ADP	IN	_	_	_	_	_
22	Raji	Raji	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
23	,	,	PUNCT	,	_	_	_	_	_
24	HF	HF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
25	,	,	PUNCT	,	_	_	_	_	_
26	BALB	BALB	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
27	/	/	PUNCT	,	_	_	_	_	SpaceAfter=No
28	c	c	NOUN	NN	Number=Sing	_	_	_	_
29	3T3	3T3	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
30	,	,	PUNCT	,	_	_	_	_	_
31	or	or	CCONJ	CC	_	_	_	_	_
32	HL	HL	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
33	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
34	60	60	NUM	CD	NumType=Card	_	_	_	_
35	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
36	,	,	PUNCT	,	_	_	_	_	_
37	but	but	CCONJ	CC	_	_	_	_	_
38	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
39	binding	binding	VERB	VBG	VerbForm=Ger	_	_	_	_
40	activity	activity	NOUN	NN	Number=Sing	_	_	_	_
41	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
42	altered	alter	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
43	only	only	ADV	RB	_	_	_	_	_
44	twofold	twofold	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
45	after	after	ADP	IN	_	_	_	_	_
46	TPA	TPa	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
47	treatment	treatment	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
48	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3207
# text = A 40-fold stimulation of chloramphenicol acetyltransferase activity mediated by four tandem repeats of the SNE could be induced within 2 h (and up to 250-fold within 6 h) after addition of TPA in DNA-transfected U-937 cells, indicating that the stimulation appeared likely to be a true protein kinase C-mediated signal transduction event rather than a differentiation response.
1	A	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
2	40	40	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
3	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
4	fold	fold	NOUN	NN	Number=Sing	_	_	_	_
5	stimulation	stimulation	NOUN	NN	Number=Sing	_	_	_	_
6	of	of	ADP	IN	_	_	_	_	_
7	chloramphenicol	chloramphenicol	NOUN	NN	Number=Sing	_	_	_	_
8	acetyltransferase	acetyltransferase	NOUN	NN	Number=Sing	_	_	_	_
9	activity	activity	NOUN	NN	Number=Sing	_	_	_	_
10	mediated	mediate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
11	by	by	ADP	IN	_	_	_	_	_
12	four	four	NUM	CD	NumType=Card	_	_	_	_
13	tandem	tandem	NOUN	NN	Number=Sing	_	_	_	_
14	repeats	repeat	NOUN	NNS	Number=Plur	_	_	_	_
15	of	of	ADP	IN	_	_	_	_	_
16	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
17	SNE	Sne	PROPN	NNP	Number=Sing	_	_	_	_
18	could	could	AUX	MD	VerbForm=Fin	_	_	_	_
19	be	be	AUX	VB	VerbForm=Inf	_	_	_	_
20	induced	induce	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
21	within	within	ADP	IN	_	_	_	_	_
22	2	2	NUM	CD	NumType=Card	_	_	_	_
23	h	h	NOUN	NN	Number=Sing	_	_	_	_
24	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
25	and	and	CCONJ	CC	_	_	_	_	_
26	up	up	ADV	RB	_	_	_	_	_
27	to	to	ADP	IN	_	_	_	_	_
28	250	250	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
29	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
30	fold	fold	NOUN	NN	Number=Sing	_	_	_	_
31	within	within	ADP	IN	_	_	_	_	_
32	6	6	NUM	CD	NumType=Card	_	_	_	_
33	h	h	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
34	)	)	PUNCT	-RRB-	_	_	_	_	_
35	after	after	ADP	IN	_	_	_	_	_
36	addition	addition	NOUN	NN	Number=Sing	_	_	_	_
37	of	of	ADP	IN	_	_	_	_	_
38	TPA	TPA	PROPN	NNP	Number=Sing	_	_	_	_
39	in	in	ADP	IN	_	_	_	_	_
40	DNA	Dna	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
41	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
42	transfected	transfect	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
43	U	U	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
44	-	-	SYM	SYM	_	_	_	_	SpaceAfter=No
45	937	937	NUM	CD	NumType=Card	_	_	_	_
46	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
47	,	,	PUNCT	,	_	_	_	_	_
48	indicating	indicate	VERB	VBG	VerbForm=Ger	_	_	_	_
49	that	that	SCONJ	IN	_	_	_	_	_
50	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
51	stimulation	stimulation	NOUN	NN	Number=Sing	_	_	_	_
52	appeared	appear	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
53	likely	likely	ADV	RB	_	_	_	_	_
54	to	to	PART	TO	_	_	_	_	_
55	be	be	AUX	VB	VerbForm=Inf	_	_	_	_
56	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
57	true	true	ADJ	JJ	Degree=Pos	_	_	_	_
58	protein	protein	NOUN	NN	Number=Sing	_	_	_	_
59	kinase	kinase	NOUN	NN	Number=Sing	_	_	_	_
60	C-	C-	PUNCT	:	_	_	_	_	SpaceAfter=No
61	mediated	mediate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
62	signal	signal	NOUN	NN	Number=Sing	_	_	_	_
63	transduction	transduction	NOUN	NN	Number=Sing	_	_	_	_
64	event	event	NOUN	NN	Number=Sing	_	_	_	_
65	rather	rather	ADV	RB	_	_	_	_	_
66	than	than	ADP	IN	_	_	_	_	_
67	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
68	differentiation	differentiation	NOUN	NN	Number=Sing	_	_	_	_
69	response	response	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
70	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3208
# text = Slight differences in the sequence of the core SRF binding site compared with that of the classical c-Fos promoter serum response element, together with differences in the spacing between the SRF and ETS motifs, appear to account for the inability of the SCMV SNEs to respond to serum induction.
1	Slight	slight	ADJ	JJ	Degree=Pos	_	_	_	_
2	differences	difference	NOUN	NNS	Number=Plur	_	_	_	_
3	in	in	ADP	IN	_	_	_	_	_
4	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
5	sequence	sequence	NOUN	NN	Number=Sing	_	_	_	_
6	of	of	ADP	IN	_	_	_	_	_
7	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
8	core	core	NOUN	NN	Number=Sing	_	_	_	_
9	SRF	SRF	SCONJ	IN	_	_	_	_	_
10	binding	bind	VERB	VBG	VerbForm=Ger	_	_	_	_
11	site	site	NOUN	NN	Number=Sing	_	_	_	_
12	compared	compare	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
13	with	with	ADP	IN	_	_	_	_	_
14	that	that	PRON	DT	Number=Sing|PronType=Dem	_	_	_	_
15	of	of	ADP	IN	_	_	_	_	_
16	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
17	classical	classical	ADJ	JJ	Degree=Pos	_	_	_	_
18	c	c	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
19	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
20	Fos	Fos	PROPN	NNP	Number=Sing	_	_	_	_
21	promoter	promoter	NOUN	NN	Number=Sing	_	_	_	_
22	serum	serum	NOUN	NN	Number=Sing	_	_	_	_
23	response	response	NOUN	NN	Number=Sing	_	_	_	_
24	element	element	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
25	,	,	PUNCT	,	_	_	_	_	_
26	together	together	ADV	RB	_	_	_	_	_
27	with	with	ADP	IN	_	_	_	_	_
28	differences	difference	NOUN	NNS	Number=Plur	_	_	_	_
29	in	in	ADP	IN	_	_	_	_	_
30	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
31	spacing	spacing	NOUN	NN	Number=Sing	_	_	_	_
32	between	between	ADP	IN	_	_	_	_	_
33	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
34	SRF	Srf	NOUN	NN	Number=Sing	_	_	_	_
35	and	and	CCONJ	CC	_	_	_	_	_
36	ETS	ets	NOUN	NN	Number=Sing	_	_	_	_
37	motifs	motif	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
38	,	,	PUNCT	,	_	_	_	_	_
39	appear	appear	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
40	to	to	PART	TO	_	_	_	_	_
41	account	account	VERB	VB	VerbForm=Inf	_	_	_	_
42	for	for	ADP	IN	_	_	_	_	_
43	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
44	inability	inability	NOUN	NN	Number=Sing	_	_	_	_
45	of	of	ADP	IN	_	_	_	_	_
46	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
47	SCMV	SCMV	PROPN	NNP	Number=Sing	_	_	_	_
48	SNEs	SNEs	PROPN	NNP	Number=Sing	_	_	_	_
49	to	to	PART	TO	_	_	_	_	_
50	respond	respond	VERB	VB	VerbForm=Inf	_	_	_	_
51	to	to	ADP	IN	_	_	_	_	_
52	serum	serum	NOUN	NN	Number=Sing	_	_	_	_
53	induction	induction	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
54	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 3209
# text = Document 003003417 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	003003417	003003417	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 3210
# text = Human T-cell leukemia virus type I Tax associates with and is negatively regulated by the NF-kappa B2 p100 gene product: implications for viral latency.
1	Human	human	ADJ	JJ	Degree=Pos	_	_	_	_
2	T-	t-	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
3	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
4	leukemia	leukemia	NOUN	NN	Number=Sing	_	_	_	_
5	virus	virus	NOUN	NN	Number=Sing	_	_	_	_
6	type	type	NOUN	NN	Number=Sing	_	_	_	_
7	I	I	PRON	PRP	Case=Nom|Number=Sing|Person=1|PronType=Prs	_	_	_	_
8	Tax	tax	PROPN	NNP	Number=Sing	_	_	_	_
9	associates	associate	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
10	with	with	ADP	IN	_	_	_	_	_
11	and	and	CCONJ	CC	_	_	_	_	_
12	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
13	negatively	negatively	ADV	RB	_	_	_	_	_
14	regulated	regulate	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
15	by	by	ADP	IN	_	_	_	_	_
16	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
17	NF	NF	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
18	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
19	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_
20	B2	b2	NUM	CD	NumType=Card	_	_	_	_
21	p100	p100	NUM	CD	NumType=Card	_	_	_	_
22	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
23	product	product	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
24	:	:	PUNCT	:	_	_	_	_	_
25	implications	implication	NOUN	NNS	Number=Plur	_	_	_	_
26	for	for	ADP	IN	_	_	_	_	_
27	viral	viral	ADJ	JJ	Degree=Pos	_	_	_	_
28	latency	latency	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
29	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 3211
# text = Human T-cell leukemia virus type I (HTLV-I) is the etiologic agent of the adult T-cell leukemia, an aggressive and often fatal malignancy of activated human CD4 T cells.
1	Human	human	ADJ	JJ	Degree=Pos	_	_	_	_
2	T-	t-	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
3	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
4	leukemia	leukemia	NOUN	NN	Number=Sing	_	_	_	_
5	virus	virus	NOUN	NN	Number=Sing	_	_	_	_
6	type	type	NOUN	NN	Number=Sing	_	_	_	_
7	I	I	PRON	PRP	Case=Nom|Number=Sing|Person=1|PronType=Prs	_	_	_	_
8	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
9	HTLV	HTLV	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
10	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
11	I	I	PRON	PRP	Case=Nom|Number=Sing|Person=1|PronType=Prs	_	_	_	SpaceAfter=No
12	)	)	PUNCT	-RRB-	_	_	_	_	_
13	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
14	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
15	etiologic	etiologic	ADJ	JJ	Degree=Pos	_	_	_	_
16	agent	agent	NOUN	NN	Number=Sing	_	_	_	_
17	of	of	ADP	IN	_	_	_	_	_
18	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
19	adult	adult	NOUN	NN	Number=Sing	_	_	_	_
20	T-	T-	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
21	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
22	leukemia	leukemia	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
23	,	,	PUNCT	,	_	_	_	_	_
24	an	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
25	aggressive	aggressive	ADJ	JJ	Degree=Pos	_	_	_	_
26	and	and	CCONJ	CC	_	_	_	_	_
27	often	often	ADV	RB	_	_	_	_	_
28	fatal	fatal	ADJ	JJ	Degree=Pos	_	_	_	_
29	malignancy	malignancy	NOUN	NN	Number=Sing	_	_	_	_
30	of	of	ADP	IN	_	_	_	_	_
31	activated	activated	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
32	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
33	CD4	Cd4	PROPN	NNP	Number=Sing	_	_	_	_
34	T	t	PROPN	NNP	Number=Sing	_	_	_	_
35	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
36	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3212
# text = HTLV-I encodes an essential 40-kDa protein termed Tax that not only transactivates the long terminal repeat of this retrovirus but also induces an array of cellular genes.
1	HTLV	Htlv	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
2	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
3	I	I	PRON	PRP	Case=Nom|Number=Sing|Person=1|PronType=Prs	_	_	_	_
4	encodes	encode	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
5	an	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
6	essential	essential	ADJ	JJ	Degree=Pos	_	_	_	_
7	40	40	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
8	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
9	kDa	kDa	NOUN	NN	Number=Sing	_	_	_	_
10	protein	protein	NOUN	NN	Number=Sing	_	_	_	_
11	termed	term	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
12	Tax	Tax	NOUN	NN	Number=Sing	_	_	_	_
13	that	that	SCONJ	IN	_	_	_	_	_
14	not	not	ADV	RB	_	_	_	_	_
15	only	only	ADV	RB	_	_	_	_	_
16	transactivates	transactivate	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
17	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
18	long	long	ADJ	JJ	Degree=Pos	_	_	_	_
19	terminal	terminal	NOUN	NN	Number=Sing	_	_	_	_
20	repeat	repeat	NOUN	NN	Number=Sing	_	_	_	_
21	of	of	ADP	IN	_	_	_	_	_
22	this	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
23	retrovirus	retrovirus	NOUN	NN	Number=Sing	_	_	_	_
24	but	but	CCONJ	CC	_	_	_	_	_
25	also	also	ADV	RB	_	_	_	_	_
26	induces	induce	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
27	an	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
28	array	array	NOUN	NN	Number=Sing	_	_	_	_
29	of	of	ADP	IN	_	_	_	_	_
30	cellular	cellular	ADJ	JJ	Degree=Pos	_	_	_	_
31	genes	gene	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
32	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3213
# text = Tax-mediated transformation of T cells likely involves the deregulated expression of various cellular genes that normally regulate lymphocyte growth produced by altered activity of various endogenous host transcription factors.
1	Tax	tax	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
2	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
3	mediated	mediate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
4	transformation	transformation	NOUN	NN	Number=Sing	_	_	_	_
5	of	of	ADP	IN	_	_	_	_	_
6	T	t	PROPN	NNP	Number=Sing	_	_	_	_
7	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
8	likely	likely	ADV	RB	_	_	_	_	_
9	involves	involf	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
10	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
11	deregulated	deregulate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
12	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
13	of	of	ADP	IN	_	_	_	_	_
14	various	various	ADJ	JJ	Degree=Pos	_	_	_	_
15	cellular	cellular	ADJ	JJ	Degree=Pos	_	_	_	_
16	genes	gene	NOUN	NNS	Number=Plur	_	_	_	_
17	that	that	PRON	WDT	PronType=Rel	_	_	_	_
18	normally	normally	ADV	RB	_	_	_	_	_
19	regulate	regulate	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
20	lymphocyte	lymphocyte	ADJ	JJ	Degree=Pos	_	_	_	_
21	growth	growth	NOUN	NN	Number=Sing	_	_	_	_
22	produced	produce	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
23	by	by	ADP	IN	_	_	_	_	_
24	altered	alter	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
25	activity	activity	NOUN	NN	Number=Sing	_	_	_	_
26	of	of	ADP	IN	_	_	_	_	_
27	various	various	ADJ	JJ	Degree=Pos	_	_	_	_
28	endogenous	endogenous	ADJ	JJ	Degree=Pos	_	_	_	_
29	host	host	NOUN	NN	Number=Sing	_	_	_	_
30	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
31	factors	factor	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
32	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3214
# text = In particular, Tax is capable of modulating the expression or activity of various host transcription factors, including members of the NF-kappa B/Rel and CREB/ATF families, as well as the cellular factors HEB-1 and p67SRF.
1	In	in	ADP	IN	_	_	_	_	_
2	particular	particular	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
3	,	,	PUNCT	,	_	_	_	_	_
4	Tax	tax	NOUN	NN	Number=Sing	_	_	_	_
5	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
6	capable	capable	ADJ	JJ	Degree=Pos	_	_	_	_
7	of	of	SCONJ	IN	_	_	_	_	_
8	modulating	modulat	VERB	VBG	VerbForm=Ger	_	_	_	_
9	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
10	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
11	or	or	CCONJ	CC	_	_	_	_	_
12	activity	activity	NOUN	NN	Number=Sing	_	_	_	_
13	of	of	ADP	IN	_	_	_	_	_
14	various	various	ADJ	JJ	Degree=Pos	_	_	_	_
15	host	host	NOUN	NN	Number=Sing	_	_	_	_
16	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
17	factors	factor	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
18	,	,	PUNCT	,	_	_	_	_	_
19	including	include	VERB	VBG	VerbForm=Ger	_	_	_	_
20	members	member	NOUN	NNS	Number=Plur	_	_	_	_
21	of	of	ADP	IN	_	_	_	_	_
22	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
23	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
24	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
25	kappa	kappa	PROPN	NNP	Number=Sing	_	_	_	_
26	B	b	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
27	/	/	PUNCT	,	_	_	_	_	SpaceAfter=No
28	Rel	Rel	PROPN	NNP	Number=Sing	_	_	_	_
29	and	and	CCONJ	CC	_	_	_	_	_
30	CREB	CREB	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
31	/	/	PUNCT	,	_	_	_	_	SpaceAfter=No
32	ATF	ATF	PROPN	NNP	Number=Sing	_	_	_	_
33	families	family	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
34	,	,	PUNCT	,	_	_	_	_	_
35	as	as	ADV	RB	_	_	_	_	_
36	well	well	ADV	RB	Degree=Pos	_	_	_	_
37	as	as	ADP	IN	_	_	_	_	_
38	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
39	cellular	cellular	ADJ	JJ	Degree=Pos	_	_	_	_
40	factors	factor	NOUN	NNS	Number=Plur	_	_	_	_
41	HEB	HEB	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
42	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
43	1	1	NUM	CD	NumType=Card	_	_	_	_
44	and	and	CCONJ	CC	_	_	_	_	_
45	p67SRF	p67srf	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
46	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3215
# text = An additional distinguishing characteristic of HTLV-I infection is the profound state of viral latency that is present in circulating primary leukemic T cells.
1	An	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
2	additional	additional	ADJ	JJ	Degree=Pos	_	_	_	_
3	distinguishing	distinguishing	ADJ	JJ	Degree=Pos	_	_	_	_
4	characteristic	characteristic	NOUN	NN	Number=Sing	_	_	_	_
5	of	of	ADP	IN	_	_	_	_	_
6	HTLV	HTLV	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
7	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
8	I	I	PRON	PRP	Case=Nom|Number=Sing|Person=1|PronType=Prs	_	_	_	_
9	infection	infection	NOUN	NN	Number=Sing	_	_	_	_
10	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
11	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
12	profound	profound	ADJ	JJ	Degree=Pos	_	_	_	_
13	state	state	NOUN	NN	Number=Sing	_	_	_	_
14	of	of	ADP	IN	_	_	_	_	_
15	viral	viral	ADJ	JJ	Degree=Pos	_	_	_	_
16	latency	latency	NOUN	NN	Number=Sing	_	_	_	_
17	that	that	PRON	WDT	PronType=Rel	_	_	_	_
18	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
19	present	present	ADJ	JJ	Degree=Pos	_	_	_	_
20	in	in	SCONJ	IN	_	_	_	_	_
21	circulating	circulate	VERB	VBG	VerbForm=Ger	_	_	_	_
22	primary	primary	ADJ	JJ	Degree=Pos	_	_	_	_
23	leukemic	leukemic	ADJ	JJ	Degree=Pos	_	_	_	_
24	T	t	PROPN	NNP	Number=Sing	_	_	_	_
25	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
26	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3216
# text = In this study, we demonstrate that HTLV-I Tax can physically associate with p100, the product of the Rel-related NF-kappa B2 gene, both in transfected cells and in HTLV-I-infected leukemic T-cell lines.
1	In	in	ADP	IN	_	_	_	_	_
2	this	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
3	study	study	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
4	,	,	PUNCT	,	_	_	_	_	_
5	we	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
6	demonstrate	demonstrate	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
7	that	that	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
8	HTLV	HTLV	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
9	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
10	I	I	PRON	PRP	Case=Nom|Number=Sing|Person=1|PronType=Prs	_	_	_	_
11	Tax	tax	NOUN	NN	Number=Sing	_	_	_	_
12	can	can	AUX	MD	VerbForm=Fin	_	_	_	_
13	physically	physically	ADV	RB	_	_	_	_	_
14	associate	associate	VERB	VB	VerbForm=Inf	_	_	_	_
15	with	with	ADP	IN	_	_	_	_	_
16	p100	p100	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
17	,	,	PUNCT	,	_	_	_	_	_
18	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
19	product	product	NOUN	NN	Number=Sing	_	_	_	_
20	of	of	ADP	IN	_	_	_	_	_
21	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
22	Rel-	rel-	SYM	SYM	_	_	_	_	SpaceAfter=No
23	related	relate	ADJ	JJ	Degree=Pos	_	_	_	_
24	NF	NF	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
25	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
26	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_
27	B2	b2	NOUN	NN	Number=Sing	_	_	_	_
28	gene	gene	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
29	,	,	PUNCT	,	_	_	_	_	_
30	both	both	CCONJ	CC	_	_	_	_	_
31	in	in	ADP	IN	_	_	_	_	_
32	transfected	transfected	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
33	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
34	and	and	CCONJ	CC	_	_	_	_	_
35	in	in	ADP	IN	_	_	_	_	_
36	HTLV	HTLV	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
37	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
38	I	I	PRON	PRP	Case=Nom|Number=Sing|Person=1|PronType=Prs	_	_	_	SpaceAfter=No
39	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
40	infected	infect	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
41	leukemic	leukemic	ADJ	JJ	Degree=Pos	_	_	_	_
42	T-	t-	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
43	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
44	lines	line	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
45	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3217
# text = Furthermore, the physical interaction of Tax with p100 leads to the inhibition of Tax-induced activation of the HTLV-I and human immunodeficiency virus type 1 long terminal repeats, reflecting p100-mediated cytoplasmic sequestration of the normally nuclearly expressed Tax protein.
1	Furthermore	furthermore	ADV	RB	_	_	_	_	SpaceAfter=No
2	,	,	PUNCT	,	_	_	_	_	_
3	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
4	physical	physical	ADJ	JJ	Degree=Pos	_	_	_	_
5	interaction	interaction	NOUN	NN	Number=Sing	_	_	_	_
6	of	of	ADP	IN	_	_	_	_	_
7	Tax	tax	NOUN	NN	Number=Sing	_	_	_	_
8	with	with	ADP	IN	_	_	_	_	_
9	p100	p100	NUM	CD	NumType=Card	_	_	_	_
10	leads	lead	NOUN	NNS	Number=Plur	_	_	_	_
11	to	to	ADP	IN	_	_	_	_	_
12	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
13	inhibition	inhibition	NOUN	NN	Number=Sing	_	_	_	_
14	of	of	ADP	IN	_	_	_	_	_
15	Tax	tax	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
16	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
17	induced	induce	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
18	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
19	of	of	ADP	IN	_	_	_	_	_
20	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
21	HTLV	HTLV	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
22	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
23	I	I	PRON	PRP	Case=Nom|Number=Sing|Person=1|PronType=Prs	_	_	_	_
24	and	and	CCONJ	CC	_	_	_	_	_
25	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
26	immunodeficiency	immunodeficiency	NOUN	NN	Number=Sing	_	_	_	_
27	virus	virus	NOUN	NN	Number=Sing	_	_	_	_
28	type	type	NOUN	NN	Number=Sing	_	_	_	_
29	1	1	NUM	CD	NumType=Card	_	_	_	_
30	long	long	ADJ	JJ	Degree=Pos	_	_	_	_
31	terminal	terminal	NOUN	NN	Number=Sing	_	_	_	_
32	repeats	repeat	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
33	,	,	PUNCT	,	_	_	_	_	_
34	reflecting	reflect	VERB	VBG	VerbForm=Ger	_	_	_	_
35	p100	p100	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
36	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
37	mediated	mediate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
38	cytoplasmic	cytoplasmic	ADJ	JJ	Degree=Pos	_	_	_	_
39	sequestration	sequestration	NOUN	NN	Number=Sing	_	_	_	_
40	of	of	ADP	IN	_	_	_	_	_
41	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
42	normally	normally	ADV	RB	_	_	_	_	_
43	nuclearly	nuclearly	ADV	RB	_	_	_	_	_
44	expressed	express	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
45	Tax	Tax	NOUN	NN	Number=Sing	_	_	_	_
46	protein	protein	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
47	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3218
# text = In contrast, a mutant of Tax that selectively fails to activate nuclear NF-kappa B expression does not associate with p100.
1	In	in	ADP	IN	_	_	_	_	_
2	contrast	contrast	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
3	,	,	PUNCT	,	_	_	_	_	_
4	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
5	mutant	mutant	NOUN	NN	Number=Sing	_	_	_	_
6	of	of	ADP	IN	_	_	_	_	_
7	Tax	tax	NOUN	NN	Number=Sing	_	_	_	_
8	that	that	PRON	WDT	PronType=Rel	_	_	_	_
9	selectively	selectively	ADV	RB	_	_	_	_	_
10	fails	fail	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
11	to	to	PART	TO	_	_	_	_	_
12	activate	activate	VERB	VB	VerbForm=Inf	_	_	_	_
13	nuclear	nuclear	ADJ	JJ	Degree=Pos	_	_	_	_
14	NF	Nf	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
15	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
16	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_
17	B	b	NOUN	NN	Number=Sing	_	_	_	_
18	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
19	does	do	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
20	not	not	PART	RB	_	_	_	_	_
21	associate	associate	VERB	VB	VerbForm=Inf	_	_	_	_
22	with	with	ADP	IN	_	_	_	_	_
23	p100	p100	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
24	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3219
# text = (ABSTRACT TRUNCATED AT 250 WORDS)
1	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
2	ABSTRACT	ABSTRACT	X	GW	_	_	_	_	_
3	TRUNCATED	Truncate	VERB	VB	Mood=Imp|VerbForm=Fin	_	_	_	_
4	AT	at	ADV	RB	_	_	_	_	_
5	250	250	NUM	CD	NumType=Card	_	_	_	_
6	WORDS	words	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
7	)	)	PUNCT	-RRB-	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 3220
# text = Document 003003419 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	003003419	003003419	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 3221
# text = A direct interaction between the adaptor protein Cbl-b and the kinase zap-70 induces a positive signal in T cells.
1	A	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
2	direct	direct	ADJ	JJ	Degree=Pos	_	_	_	_
3	interaction	interaction	NOUN	NN	Number=Sing	_	_	_	_
4	between	between	ADP	IN	_	_	_	_	_
5	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
6	adaptor	adaptor	NOUN	NN	Number=Sing	_	_	_	_
7	protein	protein	NOUN	NN	Number=Sing	_	_	_	_
8	Cbl	Cbl	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
9	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
10	b	b	NOUN	NN	Number=Sing	_	_	_	_
11	and	and	CCONJ	CC	_	_	_	_	_
12	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
13	kinase	kinase	NOUN	NN	Number=Sing	_	_	_	_
14	zap	zap	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
15	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
16	70	70	NUM	CD	NumType=Card	_	_	_	_
17	induces	induce	NOUN	NNS	Number=Plur	_	_	_	_
18	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
19	positive	positive	ADJ	JJ	Degree=Pos	_	_	_	_
20	signal	signal	NOUN	NN	Number=Sing	_	_	_	_
21	in	in	ADP	IN	_	_	_	_	_
22	T	t	PROPN	NNP	Number=Sing	_	_	_	_
23	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
24	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 3222
# text = Engagement of the T-cell receptor (TCR)-CD3 complex induces a rapid increase in the activities of Src-family and Syk/Zap-70-family kinases [1] [2].
1	Engagement	engagement	NOUN	NN	Number=Sing	_	_	_	_
2	of	of	ADP	IN	_	_	_	_	_
3	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
4	T-	t-	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
5	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
6	receptor	receptor	NOUN	NN	Number=Sing	_	_	_	_
7	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
8	TCR	TCR	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
9	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
10	-	-	PUNCT	:	_	_	_	_	SpaceAfter=No
11	CD3	CD3	NOUN	NN	Number=Sing	_	_	_	_
12	complex	complex	NOUN	NN	Number=Sing	_	_	_	_
13	induces	induce	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
14	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
15	rapid	rapid	ADJ	JJ	Degree=Pos	_	_	_	_
16	increase	increase	NOUN	NN	Number=Sing	_	_	_	_
17	in	in	ADP	IN	_	_	_	_	_
18	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
19	activities	activity	NOUN	NNS	Number=Plur	_	_	_	_
20	of	of	ADP	IN	_	_	_	_	_
21	Src-	src-	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
22	family	family	NOUN	NN	Number=Sing	_	_	_	_
23	and	and	CCONJ	CC	_	_	_	_	_
24	Syk/Zap-70-family	Syk/Zap-70-family	NOUN	NN	Number=Sing	_	_	_	_
25	kinases	kinase	NOUN	NNS	Number=Plur	_	_	_	_
26	[	[	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
27	1	1	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
28	]	]	PUNCT	-RRB-	_	_	_	_	_
29	[	[	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
30	2	2	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
31	]	]	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
32	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3223
# text = These activated kinases then induce the tyrosine phosphorylation of multiple intracellular proteins, eventually leading to T-cell activation.
1	These	these	PRON	DT	Number=Plur|PronType=Dem	_	_	_	_
2	activated	activate	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
3	kinases	kinase	NOUN	NNS	Number=Plur	_	_	_	_
4	then	then	ADV	RB	PronType=Dem	_	_	_	_
5	induce	induce	SCONJ	IN	_	_	_	_	_
6	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
7	tyrosine	tyrosine	NOUN	NN	Number=Sing	_	_	_	_
8	phosphorylation	phosphorylation	NOUN	NN	Number=Sing	_	_	_	_
9	of	of	ADP	IN	_	_	_	_	_
10	multiple	multiple	ADJ	JJ	Degree=Pos	_	_	_	_
11	intracellular	intracellular	ADJ	JJ	Degree=Pos	_	_	_	_
12	proteins	protein	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
13	,	,	PUNCT	,	_	_	_	_	_
14	eventually	eventually	ADV	RB	_	_	_	_	_
15	leading	lead	VERB	VBG	VerbForm=Ger	_	_	_	_
16	to	to	ADP	IN	_	_	_	_	_
17	T-	t-	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
18	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
19	activation	activation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
20	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3224
# text = One of the prominent substrates for these kinases is the adaptor protein Cbl [3] and recent studies suggest that Cbl negatively regulates upstream kinases such as Syk and Zap-70 [4] [5].
1	One	one	NUM	CD	NumType=Card	_	_	_	_
2	of	of	ADP	IN	_	_	_	_	_
3	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
4	prominent	prominent	ADJ	JJ	Degree=Pos	_	_	_	_
5	substrates	substrate	NOUN	NNS	Number=Plur	_	_	_	_
6	for	for	ADP	IN	_	_	_	_	_
7	these	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
8	kinases	kinase	NOUN	NNS	Number=Plur	_	_	_	_
9	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
10	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
11	adaptor	adaptor	NOUN	NN	Number=Sing	_	_	_	_
12	protein	protein	NOUN	NN	Number=Sing	_	_	_	_
13	Cbl	Cbl	PROPN	NNP	Number=Sing	_	_	_	_
14	[	[	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
15	3	3	X	LS	_	_	_	_	SpaceAfter=No
16	]	]	PUNCT	-RRB-	_	_	_	_	_
17	and	and	CCONJ	CC	_	_	_	_	_
18	recent	recent	ADJ	JJ	Degree=Pos	_	_	_	_
19	studies	study	NOUN	NNS	Number=Plur	_	_	_	_
20	suggest	suggest	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
21	that	that	SCONJ	IN	_	_	_	_	_
22	Cbl	Cbl	PROPN	NNP	Number=Sing	_	_	_	_
23	negatively	negatively	ADV	RB	_	_	_	_	_
24	regulates	regulate	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
25	upstream	upstream	ADJ	JJ	Degree=Pos	_	_	_	_
26	kinases	kinase	NOUN	NNS	Number=Plur	_	_	_	_
27	such	such	ADJ	JJ	Degree=Pos	_	_	_	_
28	as	as	ADP	IN	_	_	_	_	_
29	Syk	Syk	PROPN	NNP	Number=Sing	_	_	_	_
30	and	and	CCONJ	CC	_	_	_	_	_
31	Zap	Zap	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
32	-	-	SYM	SYM	_	_	_	_	SpaceAfter=No
33	70	70	NUM	CD	NumType=Card	_	_	_	_
34	[	[	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
35	4	4	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
36	]	]	PUNCT	-RRB-	_	_	_	_	_
37	[	[	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
38	5	5	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
39	]	]	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
40	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3225
# text = Cbl-b, a homologue of Cbl, is widely expressed in many tissues and cells including hematopoietic cells [6] [7].
1	Cbl	Cbl	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
2	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
3	b	b	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
4	,	,	PUNCT	,	_	_	_	_	_
5	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
6	homologue	homologue	NOUN	NN	Number=Sing	_	_	_	_
7	of	of	ADP	IN	_	_	_	_	_
8	Cbl	Cbl	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
9	,	,	PUNCT	,	_	_	_	_	_
10	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
11	widely	widely	ADV	RB	_	_	_	_	_
12	expressed	express	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
13	in	in	ADP	IN	_	_	_	_	_
14	many	many	ADJ	JJ	Degree=Pos	_	_	_	_
15	tissues	tissue	NOUN	NNS	Number=Plur	_	_	_	_
16	and	and	CCONJ	CC	_	_	_	_	_
17	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
18	including	include	VERB	VBG	VerbForm=Ger	_	_	_	_
19	hematopoietic	hematopoietic	ADJ	JJ	Degree=Pos	_	_	_	_
20	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
21	[	[	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
22	6	6	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
23	]	]	PUNCT	-RRB-	_	_	_	_	_
24	[	[	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
25	7	7	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
26	]	]	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
27	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3226
# text = Cbl-b undergoes rapid tyrosine phosphorylation upon stimulation of the TCR and cytokine receptors [8] [9].
1	Cbl	Cbl	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
2	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
3	b	b	NOUN	NN	Number=Sing	_	_	_	_
4	undergoes	undergo	NOUN	NNS	Number=Plur	_	_	_	_
5	rapid	rapid	ADJ	JJ	Degree=Pos	_	_	_	_
6	tyrosine	tyrosine	NOUN	NN	Number=Sing	_	_	_	_
7	phosphorylation	phosphorylation	NOUN	NN	Number=Sing	_	_	_	_
8	upon	upon	ADP	IN	_	_	_	_	_
9	stimulation	stimulation	NOUN	NN	Number=Sing	_	_	_	_
10	of	of	ADP	IN	_	_	_	_	_
11	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
12	TCR	Tcr	NOUN	NN	Number=Sing	_	_	_	_
13	and	and	CCONJ	CC	_	_	_	_	_
14	cytokine	cytokine	NOUN	NN	Number=Sing	_	_	_	_
15	receptors	receptor	NOUN	NNS	Number=Plur	_	_	_	_
16	[	[	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
17	8	8	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
18	]	]	PUNCT	-RRB-	_	_	_	_	_
19	[	[	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
20	9	9	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
21	]	]	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
22	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3227
# text = The role of Cbl-b is unclear, however.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	role	role	NOUN	NN	Number=Sing	_	_	_	_
3	of	of	ADP	IN	_	_	_	_	_
4	Cbl	Cbl	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
5	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
6	b	b	NOUN	NN	Number=Sing	_	_	_	_
7	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
8	unclear	unclear	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
9	,	,	PUNCT	,	_	_	_	_	_
10	however	however	ADV	RB	_	_	_	_	SpaceAfter=No
11	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3228
# text = Here, we show that overexpression of Cbl-b in T cells induced the constitutive activation of the transcription factor nuclear factor of activated T cells (NFAT).
1	Here	here	ADV	RB	PronType=Dem	_	_	_	SpaceAfter=No
2	,	,	PUNCT	,	_	_	_	_	_
3	we	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
4	show	show	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
5	that	that	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
6	overexpression	overexpression	NOUN	NN	Number=Sing	_	_	_	_
7	of	of	ADP	IN	_	_	_	_	_
8	Cbl	Cbl	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
9	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
10	b	b	NOUN	NN	Number=Sing	_	_	_	_
11	in	in	ADP	IN	_	_	_	_	_
12	T	t	PROPN	NNP	Number=Sing	_	_	_	_
13	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
14	induced	induce	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
15	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
16	constitutive	constitutive	ADJ	JJ	Degree=Pos	_	_	_	_
17	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
18	of	of	ADP	IN	_	_	_	_	_
19	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
20	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
21	factor	factor	NOUN	NN	Number=Sing	_	_	_	_
22	nuclear	nuclear	ADJ	JJ	Degree=Pos	_	_	_	_
23	factor	factor	NOUN	NN	Number=Sing	_	_	_	_
24	of	of	ADP	IN	_	_	_	_	_
25	activated	activate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
26	T	t	PROPN	NNP	Number=Sing	_	_	_	_
27	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
28	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
29	NFAT	NFAT	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
30	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
31	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3229
# text = A loss-of-function mutation in Cbl-b disrupted the interaction between Cbl-b and Zap-70 and nearly completely abrogated the Cbl-b-mediated activation of NFAT.
1	A	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
2	loss	loss	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
3	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
4	of	of	ADP	IN	_	_	_	_	SpaceAfter=No
5	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
6	function	function	NOUN	NN	Number=Sing	_	_	_	_
7	mutation	mutation	NOUN	NN	Number=Sing	_	_	_	_
8	in	in	ADP	IN	_	_	_	_	_
9	Cbl	Cbl	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
10	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
11	b	benefit	NOUN	NN	Number=Sing	_	_	_	_
12	disrupted	disrupt	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
13	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
14	interaction	interaction	NOUN	NN	Number=Sing	_	_	_	_
15	between	between	ADP	IN	_	_	_	_	_
16	Cbl	Cbl	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
17	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
18	b	b	NOUN	NN	Number=Sing	_	_	_	_
19	and	and	CCONJ	CC	_	_	_	_	_
20	Zap	Zap	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
21	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
22	70	70	NUM	CD	NumType=Card	_	_	_	_
23	and	and	CCONJ	CC	_	_	_	_	_
24	nearly	nearly	ADV	RB	_	_	_	_	_
25	completely	completely	ADV	RB	_	_	_	_	_
26	abrogated	abrogate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
27	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
28	Cbl	Cbl	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
29	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
30	b-	b-	SYM	SYM	_	_	_	_	SpaceAfter=No
31	mediated	mediate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
32	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
33	of	of	ADP	IN	_	_	_	_	_
34	NFAT	NFAT	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
35	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3230
# text = Unlike the proposed role of Cbl as a negative regulator, our results suggest that the Cbl homologue Cbl-b has a positive role in T-cell signaling, most likely via a direct interaction with the upstream kinase Zap-70.
1	Unlike	unlike	ADP	IN	_	_	_	_	_
2	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
3	proposed	propose	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
4	role	role	NOUN	NN	Number=Sing	_	_	_	_
5	of	of	ADP	IN	_	_	_	_	_
6	Cbl	Cbl	PROPN	NNP	Number=Sing	_	_	_	_
7	as	as	ADP	IN	_	_	_	_	_
8	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
9	negative	negative	ADJ	JJ	Degree=Pos	_	_	_	_
10	regulator	regulator	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
11	,	,	PUNCT	,	_	_	_	_	_
12	our	we	PRON	PRP$	Number=Plur|Person=1|Poss=Yes|PronType=Prs	_	_	_	_
13	results	result	NOUN	NNS	Number=Plur	_	_	_	_
14	suggest	suggest	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
15	that	that	SCONJ	IN	_	_	_	_	_
16	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
17	Cbl	Cbl	PROPN	NNP	Number=Sing	_	_	_	_
18	homologue	homologue	NOUN	NN	Number=Sing	_	_	_	_
19	Cbl	Cbl	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
20	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
21	b	b	NOUN	NN	Number=Sing	_	_	_	_
22	has	have	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
23	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
24	positive	positive	ADJ	JJ	Degree=Pos	_	_	_	_
25	role	role	NOUN	NN	Number=Sing	_	_	_	_
26	in	in	ADP	IN	_	_	_	_	_
27	T-	t-	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
28	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
29	signaling	signaling	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
30	,	,	PUNCT	,	_	_	_	_	_
31	most	most	ADV	RBS	_	_	_	_	_
32	likely	likely	ADV	RB	_	_	_	_	_
33	via	via	ADP	IN	_	_	_	_	_
34	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
35	direct	direct	ADJ	JJ	Degree=Pos	_	_	_	_
36	interaction	interaction	NOUN	NN	Number=Sing	_	_	_	_
37	with	with	ADP	IN	_	_	_	_	_
38	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
39	upstream	upstream	ADJ	JJ	Degree=Pos	_	_	_	_
40	kinase	kinase	NOUN	NN	Number=Sing	_	_	_	_
41	Zap	Zap	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
42	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
43	70	70	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
44	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 3231
# text = Document 003003421 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	003003421	003003421	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 3232
# text = Disruption of the human SCL locus by "illegitimate" V-(D)-J recombinase activity.
1	Disruption	disruption	NOUN	NN	Number=Sing	_	_	_	_
2	of	of	ADP	IN	_	_	_	_	_
3	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
4	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
5	SCL	Scl	NOUN	NN	Number=Sing	_	_	_	_
6	locus	locus	NOUN	NN	Number=Sing	_	_	_	_
7	by	by	ADP	IN	_	_	_	_	_
8	"	"	PUNCT	``	_	_	_	_	SpaceAfter=No
9	illegitimate	illegitimate	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
10	"	"	PUNCT	''	_	_	_	_	_
11	V	v	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
12	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
13	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
14	D	d	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
15	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
16	-	-	PUNCT	:	_	_	_	_	SpaceAfter=No
17	J	j	NOUN	NN	Number=Sing	_	_	_	_
18	recombinase	recombinase	NOUN	NN	Number=Sing	_	_	_	_
19	activity	activity	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
20	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 3233
# text = A fusion complementary DNA in the T cell line HSB-2 elucidates a provocative mechanism for the disruption of the putative hematopoietic transcription factor SCL.
1	A	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
2	fusion	fusion	NOUN	NN	Number=Sing	_	_	_	_
3	complementary	complementary	ADJ	JJ	Degree=Pos	_	_	_	_
4	DNA	dna	NOUN	NN	Number=Sing	_	_	_	_
5	in	in	ADP	IN	_	_	_	_	_
6	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
7	T	T	PROPN	NNP	Number=Sing	_	_	_	_
8	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
9	line	line	NOUN	NN	Number=Sing	_	_	_	_
10	HSB	Hsb	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
11	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
12	2	2	NUM	CD	NumType=Card	_	_	_	_
13	elucidates	elucidate	NOUN	NNS	Number=Plur	_	_	_	_
14	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
15	provocative	provocative	ADJ	JJ	Degree=Pos	_	_	_	_
16	mechanism	mechanism	NOUN	NN	Number=Sing	_	_	_	_
17	for	for	ADP	IN	_	_	_	_	_
18	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
19	disruption	disruption	NOUN	NN	Number=Sing	_	_	_	_
20	of	of	ADP	IN	_	_	_	_	_
21	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
22	putative	putative	ADJ	JJ	Degree=Pos	_	_	_	_
23	hematopoietic	hematopoietic	ADJ	JJ	Degree=Pos	_	_	_	_
24	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
25	factor	factor	NOUN	NN	Number=Sing	_	_	_	_
26	SCL	Scl	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
27	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3234
# text = The fusion cDNA results from an interstitial deletion between a previously unknown locus, SIL (SCL interrupting locus), and the 5' untranslated region of SCL.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	fusion	fusion	NOUN	NN	Number=Sing	_	_	_	_
3	cDNA	cDNa	NOUN	NN	Number=Sing	_	_	_	_
4	results	result	NOUN	NNS	Number=Plur	_	_	_	_
5	from	from	ADP	IN	_	_	_	_	_
6	an	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
7	interstitial	interstitial	ADJ	JJ	Degree=Pos	_	_	_	_
8	deletion	deletion	NOUN	NN	Number=Sing	_	_	_	_
9	between	between	ADP	IN	_	_	_	_	_
10	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
11	previously	previously	ADV	RB	_	_	_	_	_
12	unknown	unknown	ADJ	JJ	Degree=Pos	_	_	_	_
13	locus	locus	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
14	,	,	PUNCT	,	_	_	_	_	_
15	SIL	SIL	PROPN	NNP	Number=Sing	_	_	_	_
16	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
17	SCL	SCL	PROPN	NNP	Number=Sing	_	_	_	_
18	interrupting	interrupt	VERB	VBG	VerbForm=Ger	_	_	_	_
19	locus	locus	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
20	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
21	,	,	PUNCT	,	_	_	_	_	_
22	and	and	CCONJ	CC	_	_	_	_	_
23	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
24	5	5	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
25	'	's	PUNCT	``	_	_	_	_	_
26	untranslated	untranslated	ADJ	JJ	Degree=Pos	_	_	_	_
27	region	region	NOUN	NN	Number=Sing	_	_	_	_
28	of	of	ADP	IN	_	_	_	_	_
29	SCL	SCL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
30	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3235
# text = Similar to 1;14 translocations, this deletion disrupts the SCL 5' regulatory region.
1	Similar	similar	ADJ	JJ	Degree=Pos	_	_	_	_
2	to	to	ADP	IN	_	_	_	_	_
3	1;	1;	PUNCT	,	_	_	_	_	SpaceAfter=No
4	14	14	NUM	CD	NumType=Card	_	_	_	_
5	translocations	translocation	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
6	,	,	PUNCT	,	_	_	_	_	_
7	this	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
8	deletion	deletion	NOUN	NN	Number=Sing	_	_	_	_
9	disrupts	disrupt	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
10	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
11	SCL	Scl	NOUN	NN	Number=Sing	_	_	_	_
12	5	5	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
13	'	'	PUNCT	``	_	_	_	_	_
14	regulatory	regulatory	ADJ	JJ	Degree=Pos	_	_	_	_
15	region	region	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
16	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3236
# text = This event is probably mediated by V-(D)-J recombinase activity, although neither locus is an immunoglobulin or a T cell receptor.
1	This	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
2	event	event	NOUN	NN	Number=Sing	_	_	_	_
3	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
4	probably	probably	ADV	RB	_	_	_	_	_
5	mediated	mediate	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
6	by	by	ADP	IN	_	_	_	_	_
7	V	V	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
8	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
9	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
10	D	d	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
11	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
12	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
13	J	j	NOUN	NN	Number=Sing	_	_	_	_
14	recombinase	recombinase	NOUN	NN	Number=Sing	_	_	_	_
15	activity	activity	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
16	,	,	PUNCT	,	_	_	_	_	_
17	although	although	SCONJ	IN	_	_	_	_	_
18	neither	neither	DET	DT	_	_	_	_	_
19	locus	locus	NOUN	NN	Number=Sing	_	_	_	_
20	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
21	an	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
22	immunoglobulin	immunoglobulin	NOUN	NN	Number=Sing	_	_	_	_
23	or	or	CCONJ	CC	_	_	_	_	_
24	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
25	T	t	PROPN	NNP	Number=Sing	_	_	_	_
26	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
27	receptor	receptor	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
28	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3237
# text = Two other T cell lines, CEM and RPMI 8402, have essentially identical deletions.
1	Two	two	NUM	CD	NumType=Card	_	_	_	_
2	other	other	ADJ	JJ	Degree=Pos	_	_	_	_
3	T	t	PROPN	NNP	Number=Sing	_	_	_	_
4	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
5	lines	line	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
6	,	,	PUNCT	,	_	_	_	_	_
7	CEM	CEM	PROPN	NNP	Number=Sing	_	_	_	_
8	and	and	CCONJ	CC	_	_	_	_	_
9	RPMI	RPMI	PROPN	NNP	Number=Sing	_	_	_	_
10	8402	8402	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
11	,	,	PUNCT	,	_	_	_	_	_
12	have	have	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
13	essentially	essentially	ADV	RB	_	_	_	_	_
14	identical	identical	ADJ	JJ	Degree=Pos	_	_	_	_
15	deletions	deletion	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
16	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3238
# text = Thus, in lymphocytes, growth-affecting genes other than immune receptors risk rearrangements.
1	Thus	thus	ADV	RB	_	_	_	_	SpaceAfter=No
2	,	,	PUNCT	,	_	_	_	_	_
3	in	in	ADP	IN	_	_	_	_	_
4	lymphocytes	lymphocyte	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
5	,	,	PUNCT	,	_	_	_	_	_
6	growth	growth	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
7	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
8	affecting	affecting	VERB	VBG	VerbForm=Ger	_	_	_	_
9	genes	gene	NOUN	NNS	Number=Plur	_	_	_	_
10	other	other	ADJ	JJ	Degree=Pos	_	_	_	_
11	than	than	ADP	IN	_	_	_	_	_
12	immune	immune	ADJ	JJ	Degree=Pos	_	_	_	_
13	receptors	receptor	NOUN	NNS	Number=Plur	_	_	_	_
14	risk	risk	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
15	rearrangements	rearrangement	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
16	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 3239
# text = Document 003003423 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	003003423	003003423	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 3240
# text = Differential regulation of IL-6 gene transcription and expression by IL-4 and IL-10 in human monocytic cell lines.
1	Differential	differential	ADJ	JJ	Degree=Pos	_	_	_	_
2	regulation	regulation	NOUN	NN	Number=Sing	_	_	_	_
3	of	of	ADP	IN	_	_	_	_	_
4	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
5	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
6	6	6	NUM	CD	NumType=Card	_	_	_	_
7	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
8	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
9	and	and	CCONJ	CC	_	_	_	_	_
10	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
11	by	by	ADP	IN	_	_	_	_	_
12	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
13	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
14	4	4	NUM	CD	NumType=Card	_	_	_	_
15	and	and	CCONJ	CC	_	_	_	_	_
16	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
17	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
18	10	10	NUM	CD	NumType=Card	_	_	_	_
19	in	in	ADP	IN	_	_	_	_	_
20	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
21	monocytic	monocytic	ADJ	JJ	Degree=Pos	_	_	_	_
22	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
23	lines	line	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
24	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 3241
# text = IL-4 and IL-10 inhibit the cytokine production and mRNA expression by monocytes/macrophages.
1	IL	Il	INTJ	UH	_	_	_	_	SpaceAfter=No
2	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
3	4	4	NUM	CD	NumType=Card	_	_	_	_
4	and	and	CCONJ	CC	_	_	_	_	_
5	IL	Il	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
6	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
7	10	10	NUM	CD	NumType=Card	_	_	_	_
8	inhibit	inhibit	NOUN	NN	Number=Sing	_	_	_	_
9	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
10	cytokine	cytokine	NOUN	NN	Number=Sing	_	_	_	_
11	production	production	NOUN	NN	Number=Sing	_	_	_	_
12	and	and	CCONJ	CC	_	_	_	_	_
13	mRNA	mRNa	NOUN	NN	Number=Sing	_	_	_	_
14	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
15	by	by	ADP	IN	_	_	_	_	_
16	monocytes	monocyte	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
17	/	/	PUNCT	,	_	_	_	_	SpaceAfter=No
18	macrophages	macrophage	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
19	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3242
# text = To investigate the molecular mechanism of the inhibitory effect on transcriptional or post-transcriptional regulation of IL-6 gene expression by IL-4 and IL-10, we studied IL-6 production, expression level of IL-6 mRNA, IL-6 promoter activity, transcriptional activity of NF-kappaB and NF-IL-6, and IL-6 mRNA stability in human monocytic cell lines, THP-1 and U937, stimulated by PMA and LPS in the absence or the presence of IL-4 or IL-10.
1	To	to	PART	TO	_	_	_	_	_
2	investigate	investigate	VERB	VB	VerbForm=Inf	_	_	_	_
3	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
4	molecular	molecular	ADJ	JJ	Degree=Pos	_	_	_	_
5	mechanism	mechanism	NOUN	NN	Number=Sing	_	_	_	_
6	of	of	ADP	IN	_	_	_	_	_
7	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
8	inhibitory	inhibitory	ADJ	JJ	Degree=Pos	_	_	_	_
9	effect	effect	NOUN	NN	Number=Sing	_	_	_	_
10	on	on	ADP	IN	_	_	_	_	_
11	transcriptional	transcriptional	ADJ	JJ	Degree=Pos	_	_	_	_
12	or	or	CCONJ	CC	_	_	_	_	_
13	post	post	X	AFX	_	_	_	_	SpaceAfter=No
14	-transcriptional	-transcriptional	ADJ	JJ	Degree=Pos	_	_	_	_
15	regulation	regulation	NOUN	NN	Number=Sing	_	_	_	_
16	of	of	ADP	IN	_	_	_	_	_
17	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
18	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
19	6	6	NUM	CD	NumType=Card	_	_	_	_
20	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
21	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
22	by	by	ADP	IN	_	_	_	_	_
23	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
24	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
25	4	4	NUM	CD	NumType=Card	_	_	_	_
26	and	and	CCONJ	CC	_	_	_	_	_
27	IL	Il	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
28	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
29	10	10	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
30	,	,	PUNCT	,	_	_	_	_	_
31	we	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
32	studied	study	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
33	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
34	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
35	6	6	NUM	CD	NumType=Card	_	_	_	_
36	production	production	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
37	,	,	PUNCT	,	_	_	_	_	_
38	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
39	level	level	NOUN	NN	Number=Sing	_	_	_	_
40	of	of	ADP	IN	_	_	_	_	_
41	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
42	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
43	6	6	NUM	CD	NumType=Card	_	_	_	_
44	mRNA	mRNA	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
45	,	,	PUNCT	,	_	_	_	_	_
46	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
47	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
48	6	6	NUM	CD	NumType=Card	_	_	_	_
49	promoter	promoter	NOUN	NN	Number=Sing	_	_	_	_
50	activity	activity	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
51	,	,	PUNCT	,	_	_	_	_	_
52	transcriptional	transcriptional	ADJ	JJ	Degree=Pos	_	_	_	_
53	activity	activity	NOUN	NN	Number=Sing	_	_	_	_
54	of	of	ADP	IN	_	_	_	_	_
55	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
56	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
57	kappaB	kappaB	PROPN	NNP	Number=Sing	_	_	_	_
58	and	and	CCONJ	CC	_	_	_	_	_
59	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
60	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
61	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
62	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
63	6	6	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
64	,	,	PUNCT	,	_	_	_	_	_
65	and	and	CCONJ	CC	_	_	_	_	_
66	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
67	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
68	6	6	NUM	CD	NumType=Card	_	_	_	_
69	mRNA	mRNa	NOUN	NN	Number=Sing	_	_	_	_
70	stability	stability	NOUN	NN	Number=Sing	_	_	_	_
71	in	in	ADP	IN	_	_	_	_	_
72	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
73	monocytic	monocytic	ADJ	JJ	Degree=Pos	_	_	_	_
74	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
75	lines	line	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
76	,	,	PUNCT	,	_	_	_	_	_
77	THP	Thp	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
78	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
79	1	1	NUM	CD	NumType=Card	_	_	_	_
80	and	and	CCONJ	CC	_	_	_	_	_
81	U937	U937	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
82	,	,	PUNCT	,	_	_	_	_	_
83	stimulated	stimulate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
84	by	by	ADP	IN	_	_	_	_	_
85	PMA	PMA	PROPN	NNP	Number=Sing	_	_	_	_
86	and	and	CCONJ	CC	_	_	_	_	_
87	LPS	LPS	PROPN	NNP	Number=Sing	_	_	_	_
88	in	in	ADP	IN	_	_	_	_	_
89	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
90	absence	absence	NOUN	NN	Number=Sing	_	_	_	_
91	or	or	CCONJ	CC	_	_	_	_	_
92	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
93	presence	presence	NOUN	NN	Number=Sing	_	_	_	_
94	of	of	ADP	IN	_	_	_	_	_
95	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
96	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
97	4	4	NUM	CD	NumType=Card	_	_	_	_
98	or	or	CCONJ	CC	_	_	_	_	_
99	IL	il	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
100	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
101	10	10	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
102	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3243
# text = Both IL-4 and IL-10 were seen to inhibit IL-6 production and the expression of IL-6 mRNA in both monocytic cell lines studied.
1	Both	both	DET	DT	_	_	_	_	_
2	IL	Il	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
3	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
4	4	4	NUM	CD	NumType=Card	_	_	_	_
5	and	and	CCONJ	CC	_	_	_	_	_
6	IL	Il	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
7	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
8	10	10	NUM	CD	NumType=Card	_	_	_	_
9	were	be	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
10	seen	see	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
11	to	to	PART	TO	_	_	_	_	_
12	inhibit	inhibit	VERB	VB	VerbForm=Inf	_	_	_	_
13	IL	Il	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
14	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
15	6	6	NUM	CD	NumType=Card	_	_	_	_
16	production	production	NOUN	NN	Number=Sing	_	_	_	_
17	and	and	CCONJ	CC	_	_	_	_	_
18	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
19	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
20	of	of	ADP	IN	_	_	_	_	_
21	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
22	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
23	6	6	NUM	CD	NumType=Card	_	_	_	_
24	mRNA	mRNa	NOUN	NN	Number=Sing	_	_	_	_
25	in	in	ADP	IN	_	_	_	_	_
26	both	both	DET	DT	_	_	_	_	_
27	monocytic	monocytic	ADJ	JJ	Degree=Pos	_	_	_	_
28	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
29	lines	line	NOUN	NNS	Number=Plur	_	_	_	_
30	studied	study	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	SpaceAfter=No
31	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3244
# text = In chloramphenicol acetyltransferase assays, utilizing the transient transfection of a chloramphenicol acetyltransferase reporter plasmid containing the IL-6 gene promoter, IL-4, but not IL-10, suppressed the transcriptional activity of the IL-6 gene promoter stimulated by PMA and LPS.
1	In	in	ADP	IN	_	_	_	_	_
2	chloramphenicol	chloramphenicol	ADJ	JJ	Degree=Pos	_	_	_	_
3	acetyltransferase	acetyltransferase	NOUN	NN	Number=Sing	_	_	_	_
4	assays	assay	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	SpaceAfter=No
5	,	,	PUNCT	,	_	_	_	_	_
6	utilizing	utilize	VERB	VBG	VerbForm=Ger	_	_	_	_
7	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
8	transient	transient	ADJ	JJ	Degree=Pos	_	_	_	_
9	transfection	transfection	NOUN	NN	Number=Sing	_	_	_	_
10	of	of	ADP	IN	_	_	_	_	_
11	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
12	chloramphenicol	chloramphenicol	NOUN	NN	Number=Sing	_	_	_	_
13	acetyltransferase	acetyltransferase	NOUN	NN	Number=Sing	_	_	_	_
14	reporter	reporter	NOUN	NN	Number=Sing	_	_	_	_
15	plasmid	plasmid	NOUN	NN	Number=Sing	_	_	_	_
16	containing	contain	VERB	VBG	VerbForm=Ger	_	_	_	_
17	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
18	IL	Il	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
19	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
20	6	6	NUM	CD	NumType=Card	_	_	_	_
21	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
22	promoter	promoter	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
23	,	,	PUNCT	,	_	_	_	_	_
24	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
25	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
26	4	4	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
27	,	,	PUNCT	,	_	_	_	_	_
28	but	but	CCONJ	CC	_	_	_	_	_
29	not	not	ADV	RB	_	_	_	_	_
30	IL	Il	SYM	$	_	_	_	_	SpaceAfter=No
31	-	-	SYM	SYM	_	_	_	_	SpaceAfter=No
32	10	10	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
33	,	,	PUNCT	,	_	_	_	_	_
34	suppressed	suppress	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
35	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
36	transcriptional	transcriptional	ADJ	JJ	Degree=Pos	_	_	_	_
37	activity	activity	NOUN	NN	Number=Sing	_	_	_	_
38	of	of	ADP	IN	_	_	_	_	_
39	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
40	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
41	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
42	6	6	NUM	CD	NumType=Card	_	_	_	_
43	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
44	promoter	promoter	NOUN	NN	Number=Sing	_	_	_	_
45	stimulated	stimulate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
46	by	by	ADP	IN	_	_	_	_	_
47	PMA	PMA	PROPN	NNP	Number=Sing	_	_	_	_
48	and	and	CCONJ	CC	_	_	_	_	_
49	LPS	LPS	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
50	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3245
# text = Electrophoretic mobility shift assays showed that IL-4, but not IL-10, inhibited nuclear NF-kappaB activity, and that IL-4 and IL-10 did not affect NF-IL-6 activity.
1	Electrophoretic	Electrophoretic	ADJ	JJ	Degree=Pos	_	_	_	_
2	mobility	mobility	NOUN	NN	Number=Sing	_	_	_	_
3	shift	shift	NOUN	NN	Number=Sing	_	_	_	_
4	assays	assays	NOUN	NNS	Number=Plur	_	_	_	_
5	showed	show	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
6	that	that	SCONJ	IN	_	_	_	_	_
7	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
8	-	-	SYM	SYM	_	_	_	_	SpaceAfter=No
9	4	4	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
10	,	,	PUNCT	,	_	_	_	_	_
11	but	but	CCONJ	CC	_	_	_	_	_
12	not	not	ADV	RB	_	_	_	_	_
13	IL	Il	SYM	$	_	_	_	_	SpaceAfter=No
14	-	-	SYM	SYM	_	_	_	_	SpaceAfter=No
15	10	10	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
16	,	,	PUNCT	,	_	_	_	_	_
17	inhibited	inhibit	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
18	nuclear	nuclear	ADJ	JJ	Degree=Pos	_	_	_	_
19	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
20	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
21	kappaB	kappaB	PROPN	NNP	Number=Sing	_	_	_	_
22	activity	activity	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
23	,	,	PUNCT	,	_	_	_	_	_
24	and	and	CCONJ	CC	_	_	_	_	_
25	that	that	SCONJ	IN	_	_	_	_	_
26	IL	Il	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
27	-	-	SYM	SYM	_	_	_	_	SpaceAfter=No
28	4	4	NUM	CD	NumType=Card	_	_	_	_
29	and	and	CCONJ	CC	_	_	_	_	_
30	IL	Il	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
31	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
32	10	10	NUM	CD	NumType=Card	_	_	_	_
33	did	do	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
34	not	not	PART	RB	_	_	_	_	_
35	affect	affect	VERB	VB	VerbForm=Inf	_	_	_	_
36	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
37	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
38	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
39	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
40	6	6	NUM	CD	NumType=Card	_	_	_	_
41	activity	activity	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
42	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3246
# text = On the other hand, IL-10 enhanced the degradation of IL-6 mRNA in a mRNA stability assay.
1	On	on	ADP	IN	_	_	_	_	_
2	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
3	other	other	ADJ	JJ	Degree=Pos	_	_	_	_
4	hand	hand	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
5	,	,	PUNCT	,	_	_	_	_	_
6	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
7	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
8	10	10	NUM	CD	NumType=Card	_	_	_	_
9	enhanced	enhance	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
10	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
11	degradation	degradation	NOUN	NN	Number=Sing	_	_	_	_
12	of	of	ADP	IN	_	_	_	_	_
13	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
14	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
15	6	6	NUM	CD	NumType=Card	_	_	_	_
16	mRNA	mRNa	NOUN	NN	Number=Sing	_	_	_	_
17	in	in	ADP	IN	_	_	_	_	_
18	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
19	mRNA	mRNA	PROPN	NNP	Number=Sing	_	_	_	_
20	stability	stability	NOUN	NN	Number=Sing	_	_	_	_
21	assay	assay	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
22	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3247
# text = These results suggest that IL-4 may inhibit the transcription of the IL-6 gene by affecting NF-kappaB binding activity, while IL-10 may inhibit the IL-6 mRNA levels post-transcriptionally, without suppressing promoter activity.
1	These	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
2	results	result	NOUN	NNS	Number=Plur	_	_	_	_
3	suggest	suggest	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
4	that	that	SCONJ	IN	_	_	_	_	_
5	IL	Il	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
6	-	-	SYM	SYM	_	_	_	_	SpaceAfter=No
7	4	4	NUM	CD	NumType=Card	_	_	_	_
8	may	may	AUX	MD	VerbForm=Fin	_	_	_	_
9	inhibit	inhibit	VERB	VB	VerbForm=Inf	_	_	_	_
10	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
11	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
12	of	of	ADP	IN	_	_	_	_	_
13	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
14	IL	Il	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
15	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
16	6	6	NUM	CD	NumType=Card	_	_	_	_
17	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
18	by	by	SCONJ	IN	_	_	_	_	_
19	affecting	affect	VERB	VBG	VerbForm=Ger	_	_	_	_
20	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
21	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
22	kappaB	kappaB	PROPN	NNP	Number=Sing	_	_	_	_
23	binding	binding	VERB	VBG	VerbForm=Ger	_	_	_	_
24	activity	activity	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
25	,	,	PUNCT	,	_	_	_	_	_
26	while	while	SCONJ	IN	_	_	_	_	_
27	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
28	-	-	SYM	SYM	_	_	_	_	SpaceAfter=No
29	10	10	NUM	CD	NumType=Card	_	_	_	_
30	may	may	AUX	MD	VerbForm=Fin	_	_	_	_
31	inhibit	inhibit	VERB	VB	VerbForm=Inf	_	_	_	_
32	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
33	IL	Il	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
34	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
35	6	6	NUM	CD	NumType=Card	_	_	_	_
36	mRNA	mRNa	NOUN	NN	Number=Sing	_	_	_	_
37	levels	level	NOUN	NNS	Number=Plur	_	_	_	_
38	post-transcriptionally	post-transcriptionally	ADV	RB	_	_	_	_	SpaceAfter=No
39	,	,	PUNCT	,	_	_	_	_	_
40	without	without	SCONJ	IN	_	_	_	_	_
41	suppressing	suppresse	VERB	VBG	VerbForm=Ger	_	_	_	_
42	promoter	promoter	ADJ	JJ	Degree=Pos	_	_	_	_
43	activity	activity	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
44	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3248
# text = Therefore, we conclude that IL-4 and IL-10 inhibit IL-6 production by different mechanisms in human monocytic cell lines.
1	Therefore	therefore	ADV	RB	_	_	_	_	SpaceAfter=No
2	,	,	PUNCT	,	_	_	_	_	_
3	we	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
4	conclude	conclude	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
5	that	that	SCONJ	IN	_	_	_	_	_
6	IL	Il	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
7	-	-	SYM	SYM	_	_	_	_	SpaceAfter=No
8	4	4	NUM	CD	NumType=Card	_	_	_	_
9	and	and	CCONJ	CC	_	_	_	_	_
10	IL	Il	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
11	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
12	10	10	NUM	CD	NumType=Card	_	_	_	_
13	inhibit	inhibit	NOUN	NN	Number=Sing	_	_	_	_
14	IL	Il	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
15	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
16	6	6	NUM	CD	NumType=Card	_	_	_	_
17	production	production	NOUN	NN	Number=Sing	_	_	_	_
18	by	by	ADP	IN	_	_	_	_	_
19	different	different	ADJ	JJ	Degree=Pos	_	_	_	_
20	mechanisms	mechanism	NOUN	NNS	Number=Plur	_	_	_	_
21	in	in	ADP	IN	_	_	_	_	_
22	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
23	monocytic	monocytic	ADJ	JJ	Degree=Pos	_	_	_	_
24	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
25	lines	line	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
26	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 3249
# text = Document 003003424 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	003003424	003003424	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 3250
# text = Flutamide in the treatment of hirsutism: long-term clinical effects, endocrine changes, and androgen receptor behavior.
1	Flutamide	Flutamide	VERB	VB	Mood=Imp|VerbForm=Fin	_	_	_	_
2	in	in	ADP	IN	_	_	_	_	_
3	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
4	treatment	treatment	NOUN	NN	Number=Sing	_	_	_	_
5	of	of	ADP	IN	_	_	_	_	_
6	hirsutism	hirsutism	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
7	:	:	PUNCT	:	_	_	_	_	_
8	long	long	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
9	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
10	term	term	NOUN	NN	Number=Sing	_	_	_	_
11	clinical	clinical	NOUN	NN	Number=Sing	_	_	_	_
12	effects	effect	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
13	,	,	PUNCT	,	_	_	_	_	_
14	endocrine	endocrine	VERB	VB	Mood=Imp|VerbForm=Fin	_	_	_	_
15	changes	change	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
16	,	,	PUNCT	,	_	_	_	_	_
17	and	and	CCONJ	CC	_	_	_	_	_
18	androgen	androgen	ADJ	JJ	Degree=Pos	_	_	_	_
19	receptor	receptor	NOUN	NN	Number=Sing	_	_	_	_
20	behavior	behavior	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
21	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 3251
# text = OBJECTIVE:
1	OBJECTIVE	objective	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
2	:	:	PUNCT	:	_	_	_	_	_

# sent_id = 3252
# text = To investigate the long-term effects of treatment with low doses of flutamide on clinical and hormonal parameters, as well as on the androgen receptor status, in hirsute women.
1	To	to	PART	TO	_	_	_	_	_
2	investigate	investigate	VERB	VB	VerbForm=Inf	_	_	_	_
3	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
4	long	long	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
5	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
6	term	term	NOUN	NN	Number=Sing	_	_	_	_
7	effects	effect	NOUN	NNS	Number=Plur	_	_	_	_
8	of	of	ADP	IN	_	_	_	_	_
9	treatment	treatment	NOUN	NN	Number=Sing	_	_	_	_
10	with	with	ADP	IN	_	_	_	_	_
11	low	low	ADJ	JJ	Degree=Pos	_	_	_	_
12	doses	dos	NOUN	NNS	Number=Plur	_	_	_	_
13	of	of	ADP	IN	_	_	_	_	_
14	flutamide	flutamide	NOUN	NN	Number=Sing	_	_	_	_
15	on	on	ADP	IN	_	_	_	_	_
16	clinical	clinical	ADJ	JJ	Degree=Pos	_	_	_	_
17	and	and	CCONJ	CC	_	_	_	_	_
18	hormonal	hormonal	ADJ	JJ	Degree=Pos	_	_	_	_
19	parameters	parameter	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
20	,	,	PUNCT	,	_	_	_	_	_
21	as	as	ADV	RB	_	_	_	_	_
22	well	well	ADV	RB	Degree=Pos	_	_	_	_
23	as	as	ADP	IN	_	_	_	_	_
24	on	on	ADP	IN	_	_	_	_	_
25	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
26	androgen	androgen	ADJ	JJ	Degree=Pos	_	_	_	_
27	receptor	receptor	NOUN	NN	Number=Sing	_	_	_	_
28	status	status	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
29	,	,	PUNCT	,	_	_	_	_	_
30	in	in	ADP	IN	_	_	_	_	_
31	hirsute	hirsute	ADJ	JJ	Degree=Pos	_	_	_	_
32	women	woman	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
33	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3253
# text = DESIGN:
1	DESIGN	Design	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
2	:	:	PUNCT	:	_	_	_	_	_

# sent_id = 3254
# text = Eighteen hirsute patients with regular menses were studied basally and during treatment with 125 mg flutamide, three times per day for 12 months.
1	Eighteen	eighteen	NUM	CD	NumType=Card	_	_	_	_
2	hirsute	hirsute	ADJ	JJ	Degree=Pos	_	_	_	_
3	patients	patient	NOUN	NNS	Number=Plur	_	_	_	_
4	with	with	ADP	IN	_	_	_	_	_
5	regular	regular	ADJ	JJ	Degree=Pos	_	_	_	_
6	menses	mense	NOUN	NNS	Number=Plur	_	_	_	_
7	were	be	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
8	studied	study	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
9	basally	basally	ADV	RB	_	_	_	_	_
10	and	and	CCONJ	CC	_	_	_	_	_
11	during	during	ADP	IN	_	_	_	_	_
12	treatment	treatment	NOUN	NN	Number=Sing	_	_	_	_
13	with	with	ADP	IN	_	_	_	_	_
14	125	125	NUM	CD	NumType=Card	_	_	_	_
15	mg	mg	NOUN	NN	Number=Sing	_	_	_	_
16	flutamide	flutamide	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
17	,	,	PUNCT	,	_	_	_	_	_
18	three	three	NUM	CD	NumType=Card	_	_	_	_
19	times	time	NOUN	NNS	Number=Plur	_	_	_	_
20	per	per	ADP	IN	_	_	_	_	_
21	day	day	NOUN	NN	Number=Sing	_	_	_	_
22	for	for	ADP	IN	_	_	_	_	_
23	12	12	NUM	CD	NumType=Card	_	_	_	_
24	months	month	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
25	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3255
# text = Barrier or intrauterine contraception was used during the study in sexually active women.
1	Barrier	barrier	NOUN	NN	Number=Sing	_	_	_	_
2	or	or	CCONJ	CC	_	_	_	_	_
3	intrauterine	intrauterine	NOUN	NN	Number=Sing	_	_	_	_
4	contraception	contraception	NOUN	NN	Number=Sing	_	_	_	_
5	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
6	used	use	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
7	during	during	ADP	IN	_	_	_	_	_
8	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
9	study	study	NOUN	NN	Number=Sing	_	_	_	_
10	in	in	ADP	IN	_	_	_	_	_
11	sexually	sexually	ADV	RB	_	_	_	_	_
12	active	active	ADJ	JJ	Degree=Pos	_	_	_	_
13	women	woman	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
14	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3256
# text = Safety parameters were assessed throughout the study.
1	Safety	Safety	PROPN	NNP	Number=Sing	_	_	_	_
2	parameters	parameter	NOUN	NNS	Number=Plur	_	_	_	_
3	were	be	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
4	assessed	assess	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
5	throughout	throughout	ADP	IN	_	_	_	_	_
6	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
7	study	study	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
8	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3257
# text = Hirsutism, graded by the modified Ferriman-Gallwey score, and hormonal parameters were evaluated basally and at 4-month intervals during treatment.
1	Hirsutism	Hirsutism	INTJ	UH	_	_	_	_	SpaceAfter=No
2	,	,	PUNCT	,	_	_	_	_	_
3	graded	grad	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
4	by	by	ADP	IN	_	_	_	_	_
5	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
6	modified	modify	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
7	Ferriman	Ferriman	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
8	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
9	Gallwey	Gallwey	PROPN	NNP	Number=Sing	_	_	_	_
10	score	score	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
11	,	,	PUNCT	,	_	_	_	_	_
12	and	and	CCONJ	CC	_	_	_	_	_
13	hormonal	hormonal	ADJ	JJ	Degree=Pos	_	_	_	_
14	parameters	parameter	NOUN	NNS	Number=Plur	_	_	_	_
15	were	be	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
16	evaluated	evaluate	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
17	basally	basally	ADV	RB	_	_	_	_	_
18	and	and	CCONJ	CC	_	_	_	_	_
19	at	at	ADP	IN	_	_	_	_	_
20	4	4	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
21	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
22	month	month	NOUN	NN	Number=Sing	_	_	_	_
23	intervals	interval	NOUN	NNS	Number=Plur	_	_	_	_
24	during	during	ADP	IN	_	_	_	_	_
25	treatment	treatment	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
26	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3258
# text = Gonadotropin-releasing hormone and ACTH stimulation tests were performed before and after 3 to 4 months of therapy.
1	Gonadotropin	Gonadotropin	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
2	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
3	releasing	release	VERB	VBG	VerbForm=Ger	_	_	_	_
4	hormone	hormone	NOUN	NN	Number=Sing	_	_	_	_
5	and	and	CCONJ	CC	_	_	_	_	_
6	ACTH	Acth	DET	DT	_	_	_	_	_
7	stimulation	stimulation	NOUN	NN	Number=Sing	_	_	_	_
8	tests	test	NOUN	NNS	Number=Plur	_	_	_	_
9	were	be	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
10	performed	perform	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
11	before	before	ADV	RB	_	_	_	_	_
12	and	and	CCONJ	CC	_	_	_	_	_
13	after	after	ADP	IN	_	_	_	_	_
14	3	3	NUM	CD	NumType=Card	_	_	_	_
15	to	to	ADP	IN	_	_	_	_	_
16	4	4	NUM	CD	NumType=Card	_	_	_	_
17	months	month	NOUN	NNS	Number=Plur	_	_	_	_
18	of	of	ADP	IN	_	_	_	_	_
19	therapy	therapy	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
20	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3259
# text = In addition, the concentration of androgen receptors in mononuclear leukocytes was measured, in both the follicular and luteal phases of the menstrual cycle, basally and after 4 months of flutamide treatment.
1	In	in	ADP	IN	_	_	_	_	_
2	addition	addition	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
3	,	,	PUNCT	,	_	_	_	_	_
4	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
5	concentration	concentration	NOUN	NN	Number=Sing	_	_	_	_
6	of	of	ADP	IN	_	_	_	_	_
7	androgen	androgen	ADJ	JJ	Degree=Pos	_	_	_	_
8	receptors	receptor	NOUN	NNS	Number=Plur	_	_	_	_
9	in	in	ADP	IN	_	_	_	_	_
10	mononuclear	mononuclear	ADJ	JJ	Degree=Pos	_	_	_	_
11	leukocytes	leukocyte	NOUN	NNS	Number=Plur	_	_	_	_
12	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
13	measured	measure	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	SpaceAfter=No
14	,	,	PUNCT	,	_	_	_	_	_
15	in	in	ADP	IN	_	_	_	_	_
16	both	both	CCONJ	CC	_	_	_	_	_
17	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
18	follicular	follicular	ADJ	JJ	Degree=Pos	_	_	_	_
19	and	and	CCONJ	CC	_	_	_	_	_
20	luteal	luteal	ADJ	JJ	Degree=Pos	_	_	_	_
21	phases	phase	NOUN	NNS	Number=Plur	_	_	_	_
22	of	of	ADP	IN	_	_	_	_	_
23	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
24	menstrual	menstrual	ADJ	JJ	Degree=Pos	_	_	_	_
25	cycle	cycle	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
26	,	,	PUNCT	,	_	_	_	_	_
27	basally	basally	ADV	RB	_	_	_	_	_
28	and	and	CCONJ	CC	_	_	_	_	_
29	after	after	ADP	IN	_	_	_	_	_
30	4	4	NUM	CD	NumType=Card	_	_	_	_
31	months	month	NOUN	NNS	Number=Plur	_	_	_	_
32	of	of	ADP	IN	_	_	_	_	_
33	flutamide	flutamide	ADJ	JJ	Degree=Pos	_	_	_	_
34	treatment	treatment	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
35	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3260
# text = RESULTS:
1	RESULTS	result	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
2	:	:	PUNCT	:	_	_	_	_	_

# sent_id = 3261
# text = Flutamide was well tolerated in all women, with the noticeable exception of one patient who presented increased serum transaminase after 8 months of therapy.
1	Flutamide	Flutamide	PROPN	NNP	Number=Sing	_	_	_	_
2	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
3	well	well	ADV	RB	Degree=Pos	_	_	_	_
4	tolerated	tolerate	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
5	in	in	ADP	IN	_	_	_	_	_
6	all	all	DET	DT	_	_	_	_	_
7	women	woman	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
8	,	,	PUNCT	,	_	_	_	_	_
9	with	with	ADP	IN	_	_	_	_	_
10	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
11	noticeable	noticeable	ADJ	JJ	Degree=Pos	_	_	_	_
12	exception	exception	NOUN	NN	Number=Sing	_	_	_	_
13	of	of	ADP	IN	_	_	_	_	_
14	one	one	NUM	CD	NumType=Card	_	_	_	_
15	patient	patient	NOUN	NN	Number=Sing	_	_	_	_
16	who	who	PRON	WP	PronType=Rel	_	_	_	_
17	presented	present	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
18	increased	increase	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
19	serum	serum	NOUN	NN	Number=Sing	_	_	_	_
20	transaminase	transaminase	NOUN	NN	Number=Sing	_	_	_	_
21	after	after	ADP	IN	_	_	_	_	_
22	8	8	NUM	CD	NumType=Card	_	_	_	_
23	months	month	NOUN	NNS	Number=Plur	_	_	_	_
24	of	of	ADP	IN	_	_	_	_	_
25	therapy	therapy	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
26	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3262
# text = Hirsutism markedly improved in all women during the treatment (Ferriman-Gallwey score after 1 year: 4.1 +/- 0.5 versus 14.1 +/- 0.9).
1	Hirsutism	Hirsutism	INTJ	UH	_	_	_	_	_
2	markedly	markedly	ADV	RB	_	_	_	_	_
3	improved	improve	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
4	in	in	ADP	IN	_	_	_	_	_
5	all	all	DET	DT	_	_	_	_	_
6	women	woman	NOUN	NNS	Number=Plur	_	_	_	_
7	during	during	ADP	IN	_	_	_	_	_
8	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
9	treatment	treatment	NOUN	NN	Number=Sing	_	_	_	_
10	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
11	Ferriman	Ferriman	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
12	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
13	Gallwey	Gallwey	PROPN	NNP	Number=Sing	_	_	_	_
14	score	score	NOUN	NN	Number=Sing	_	_	_	_
15	after	after	ADP	IN	_	_	_	_	_
16	1	1	NUM	CD	NumType=Card	_	_	_	_
17	year	year	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
18	:	:	PUNCT	:	_	_	_	_	_
19	4.1	4.1	NUM	CD	NumType=Card	_	_	_	_
20	+/-	+/-	SYM	SYM	_	_	_	_	_
21	0.5	0.5	NUM	CD	NumType=Card	_	_	_	_
22	versus	versus	ADP	IN	_	_	_	_	_
23	14.1	14.1	NUM	CD	NumType=Card	_	_	_	_
24	+/-	+/-	SYM	SYM	_	_	_	_	_
25	0.9	0.9	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
26	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
27	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3263
# text = A reduction of serum androgens was found, whereas no change was observed in either basal or GnRH-stimulated gonadotropins or in the cortisol and 17 alpha-hydroxyprogesterone response to ACTH.
1	A	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
2	reduction	reduction	NOUN	NN	Number=Sing	_	_	_	_
3	of	of	ADP	IN	_	_	_	_	_
4	serum	serum	NOUN	NN	Number=Sing	_	_	_	_
5	androgens	androgen	NOUN	NNS	Number=Plur	_	_	_	_
6	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
7	found	find	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	SpaceAfter=No
8	,	,	PUNCT	,	_	_	_	_	_
9	whereas	whereas	SCONJ	IN	_	_	_	_	_
10	no	no	DET	DT	_	_	_	_	_
11	change	change	NOUN	NN	Number=Sing	_	_	_	_
12	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
13	observed	observe	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
14	in	in	ADP	IN	_	_	_	_	_
15	either	either	DET	DT	_	_	_	_	_
16	basal	basal	NOUN	NN	Number=Sing	_	_	_	_
17	or	or	CCONJ	CC	_	_	_	_	_
18	GnRH	GnRh	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
19	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
20	stimulated	stimulate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
21	gonadotropins	gonadotropin	NOUN	NNS	Number=Plur	_	_	_	_
22	or	or	CCONJ	CC	_	_	_	_	_
23	in	in	ADP	IN	_	_	_	_	_
24	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
25	cortisol	cortisol	NOUN	NN	Number=Sing	_	_	_	_
26	and	and	CCONJ	CC	_	_	_	_	_
27	17	17	NUM	CD	NumType=Card	_	_	_	_
28	alpha	alpha	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
29	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
30	hydroxyprogesterone	hydroxyprogesterone	NOUN	NN	Number=Sing	_	_	_	_
31	response	response	NOUN	NN	Number=Sing	_	_	_	_
32	to	to	ADP	IN	_	_	_	_	_
33	ACTH	ACTH	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
34	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3264
# text = Cycles remained ovulatory.
1	Cycles	cycle	NOUN	NNS	Number=Plur	_	_	_	_
2	remained	remain	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
3	ovulatory	ovulatory	ADV	RB	_	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3265
# text = Before treatment, the number of androgen receptors was higher in the luteal than in the follicular phase.
1	Before	before	ADP	IN	_	_	_	_	_
2	treatment	treatment	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
3	,	,	PUNCT	,	_	_	_	_	_
4	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
5	number	number	NOUN	NN	Number=Sing	_	_	_	_
6	of	of	ADP	IN	_	_	_	_	_
7	androgen	androgen	ADJ	JJ	Degree=Pos	_	_	_	_
8	receptors	receptor	NOUN	NNS	Number=Plur	_	_	_	_
9	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
10	higher	higher	ADJ	JJR	Degree=Cmp	_	_	_	_
11	in	in	ADP	IN	_	_	_	_	_
12	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
13	luteal	luteal	NOUN	NN	Number=Sing	_	_	_	_
14	than	than	ADP	IN	_	_	_	_	_
15	in	in	ADP	IN	_	_	_	_	_
16	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
17	follicular	follicular	ADJ	JJ	Degree=Pos	_	_	_	_
18	phase	phase	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
19	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3266
# text = This rhythmic differentiation disappeared after the patients had been given the antiandrogen drug.
1	This	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
2	rhythmic	rhythmic	ADJ	JJ	Degree=Pos	_	_	_	_
3	differentiation	differentiation	NOUN	NN	Number=Sing	_	_	_	_
4	disappeared	disappear	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
5	after	after	ADP	IN	_	_	_	_	_
6	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
7	patients	patient	NOUN	NN	Number=Sing	_	_	_	_
8	had	have	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
9	been	be	AUX	VBN	Tense=Past|VerbForm=Part	_	_	_	_
10	given	give	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
11	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
12	antiandrogen	antiandrogen	ADJ	JJ	Degree=Pos	_	_	_	_
13	drug	drug	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
14	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3267
# text = CONCLUSIONS:
1	CONCLUSIONS	conclusion	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
2	:	:	PUNCT	:	_	_	_	_	_

# sent_id = 3268
# text = Flutamide is effective in the treatment of hirsutism but requires constant surveillance of liver function.
1	Flutamide	Flutamide	PROPN	NNP	Number=Sing	_	_	_	_
2	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
3	effective	effective	ADJ	JJ	Degree=Pos	_	_	_	_
4	in	in	ADP	IN	_	_	_	_	_
5	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
6	treatment	treatment	NOUN	NN	Number=Sing	_	_	_	_
7	of	of	ADP	IN	_	_	_	_	_
8	hirsutism	hirsutism	NOUN	NN	Number=Sing	_	_	_	_
9	but	but	CCONJ	CC	_	_	_	_	_
10	requires	require	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
11	constant	constant	ADJ	JJ	Degree=Pos	_	_	_	_
12	surveillance	surveillance	NOUN	NN	Number=Sing	_	_	_	_
13	of	of	ADP	IN	_	_	_	_	_
14	liver	liver	NOUN	NN	Number=Sing	_	_	_	_
15	function	function	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
16	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3269
# text = Androgen receptor blockade might be potentiated by a reduction of serum androgens.
1	Androgen	Androgen	ADJ	JJ	Degree=Pos	_	_	_	_
2	receptor	receptor	NOUN	NN	Number=Sing	_	_	_	_
3	blockade	blockade	NOUN	NN	Number=Sing	_	_	_	_
4	might	might	AUX	MD	VerbForm=Fin	_	_	_	_
5	be	be	AUX	VB	VerbForm=Inf	_	_	_	_
6	potentiated	potentiate	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
7	by	by	ADP	IN	_	_	_	_	_
8	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
9	reduction	reduction	NOUN	NN	Number=Sing	_	_	_	_
10	of	of	ADP	IN	_	_	_	_	_
11	serum	serum	NOUN	NN	Number=Sing	_	_	_	_
12	androgens	androgen	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
13	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3270
# text = Flutamide affects androgen receptor behavior during the menstrual cycle.
1	Flutamide	Flutamide	VERB	VB	Mood=Imp|VerbForm=Fin	_	_	_	_
2	affects	affect	PRON	PRP$	Gender=Neut|Number=Sing|Person=3|Poss=Yes|PronType=Prs	_	_	_	_
3	androgen	androgen	ADJ	JJ	Degree=Pos	_	_	_	_
4	receptor	receptor	NOUN	NN	Number=Sing	_	_	_	_
5	behavior	behavior	NOUN	NN	Number=Sing	_	_	_	_
6	during	during	ADP	IN	_	_	_	_	_
7	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
8	menstrual	menstrual	ADJ	JJ	Degree=Pos	_	_	_	_
9	cycle	cycle	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
10	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3271
# text = The meaning of this finding remains to be elucidated .
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	meaning	meaning	NOUN	NN	Number=Sing	_	_	_	_
3	of	of	ADP	IN	_	_	_	_	_
4	this	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
5	finding	finding	NOUN	NN	Number=Sing	_	_	_	_
6	remains	remain	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
7	to	to	PART	TO	_	_	_	_	_
8	be	be	AUX	VB	VerbForm=Inf	_	_	_	_
9	elucidated	elucidate	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
10	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 3272
# text = Document 003003430 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	003003430	003003430	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 3273
# text = E1A gene expression induces susceptibility to killing by NK cells following immortalization but not adenovirus infection of human cells.
1	E1A	E1a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
2	gene	gene	ADJ	JJ	Degree=Pos	_	_	_	_
3	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
4	induces	induce	NOUN	NNS	Number=Plur	_	_	_	_
5	susceptibility	susceptibility	NOUN	NN	Number=Sing	_	_	_	_
6	to	to	SCONJ	IN	_	_	_	_	_
7	killing	kill	VERB	VBG	VerbForm=Ger	_	_	_	_
8	by	by	ADP	IN	_	_	_	_	_
9	NK	NK	PROPN	NNP	Number=Sing	_	_	_	_
10	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
11	following	follow	VERB	VBG	VerbForm=Ger	_	_	_	_
12	immortalization	immortalization	NOUN	NN	Number=Sing	_	_	_	_
13	but	but	CCONJ	CC	_	_	_	_	_
14	not	not	ADV	RB	_	_	_	_	_
15	adenovirus	adenovirus	ADJ	JJ	Degree=Pos	_	_	_	_
16	infection	infection	NOUN	NN	Number=Sing	_	_	_	_
17	of	of	ADP	IN	_	_	_	_	_
18	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
19	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
20	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 3274
# text = Adenovirus
1	Adenovirus	Adenovirus	PROPN	NNP	Number=Sing	_	_	_	_

# sent_id = 3275
# text = (Ad) infection and E1A transfection were used to model changes in susceptibility to NK cell killing caused by transient vs stable E1A expression in human cells.
1	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
2	Ad	ad	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
3	)	)	PUNCT	-RRB-	_	_	_	_	_
4	infection	infection	NOUN	NN	Number=Sing	_	_	_	_
5	and	and	CCONJ	CC	_	_	_	_	_
6	E1A	E1a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
7	transfection	transfection	NOUN	NN	Number=Sing	_	_	_	_
8	were	be	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
9	used	use	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
10	to	to	ADP	IN	_	_	_	_	_
11	model	model	NOUN	NN	Number=Sing	_	_	_	_
12	changes	change	NOUN	NNS	Number=Plur	_	_	_	_
13	in	in	ADP	IN	_	_	_	_	_
14	susceptibility	susceptibility	NOUN	NN	Number=Sing	_	_	_	_
15	to	to	ADP	IN	_	_	_	_	_
16	NK	Nk	PROPN	NNP	Number=Sing	_	_	_	_
17	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
18	killing	kill	NOUN	NN	Number=Sing	_	_	_	_
19	caused	cause	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
20	by	by	ADP	IN	_	_	_	_	_
21	transient	transient	NOUN	NN	Number=Sing	_	_	_	_
22	vs	versus	ADP	IN	Abbr=Yes	_	_	_	_
23	stable	stable	ADJ	JJ	Degree=Pos	_	_	_	_
24	E1	E1	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
25	A	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
26	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
27	in	in	ADP	IN	_	_	_	_	_
28	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
29	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
30	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3276
# text = Only stably transfected target cells exhibited cytolytic susceptibility, despite expression of equivalent levels of E1A proteins in Ad-infected targets.
1	Only	only	ADV	RB	_	_	_	_	_
2	stably	stably	ADV	RB	_	_	_	_	_
3	transfected	transfect	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
4	target	target	NOUN	NN	Number=Sing	_	_	_	_
5	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
6	exhibited	exhibite	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
7	cytolytic	cytolytic	ADJ	JJ	Degree=Pos	_	_	_	_
8	susceptibility	susceptibility	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
9	,	,	PUNCT	,	_	_	_	_	_
10	despite	despite	ADP	IN	_	_	_	_	_
11	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
12	of	of	ADP	IN	_	_	_	_	_
13	equivalent	equivalent	ADJ	JJ	Degree=Pos	_	_	_	_
14	levels	level	NOUN	NNS	Number=Plur	_	_	_	_
15	of	of	ADP	IN	_	_	_	_	_
16	E1A	E1a	NOUN	NN	Number=Sing	_	_	_	_
17	proteins	protein	NOUN	NNS	Number=Plur	_	_	_	_
18	in	in	ADP	IN	_	_	_	_	_
19	Ad	ad	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
20	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
21	infected	infect	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
22	targets	target	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
23	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3277
# text = The inability of E1A gene products to induce cytolytic susceptibility during infection was not explained by an inhibitory effect of viral infection on otherwise susceptible target cells or by viral gene effects on class I MHC antigen expression on target cells.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	inability	inability	NOUN	NN	Number=Sing	_	_	_	_
3	of	of	ADP	IN	_	_	_	_	_
4	E1	E1	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
5	A	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
6	gene	gene	ADJ	JJ	Degree=Pos	_	_	_	_
7	products	product	NOUN	NNS	Number=Plur	_	_	_	_
8	to	to	PART	TO	_	_	_	_	_
9	induce	induce	VERB	VB	VerbForm=Inf	_	_	_	_
10	cytolytic	cytolytic	ADJ	JJ	Degree=Pos	_	_	_	_
11	susceptibility	susceptibility	NOUN	NN	Number=Sing	_	_	_	_
12	during	during	ADP	IN	_	_	_	_	_
13	infection	infection	NOUN	NN	Number=Sing	_	_	_	_
14	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
15	not	not	PART	RB	_	_	_	_	_
16	explained	explain	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
17	by	by	ADP	IN	_	_	_	_	_
18	an	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
19	inhibitory	inhibitory	ADJ	JJ	Degree=Pos	_	_	_	_
20	effect	effect	NOUN	NN	Number=Sing	_	_	_	_
21	of	of	ADP	IN	_	_	_	_	_
22	viral	viral	ADJ	JJ	Degree=Pos	_	_	_	_
23	infection	infection	NOUN	NN	Number=Sing	_	_	_	_
24	on	on	ADP	IN	_	_	_	_	_
25	otherwise	otherwise	ADV	RB	_	_	_	_	_
26	susceptible	susceptible	ADJ	JJ	Degree=Pos	_	_	_	_
27	target	target	NOUN	NN	Number=Sing	_	_	_	_
28	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
29	or	or	CCONJ	CC	_	_	_	_	_
30	by	by	ADP	IN	_	_	_	_	_
31	viral	viral	ADJ	JJ	Degree=Pos	_	_	_	_
32	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
33	effects	effect	NOUN	NNS	Number=Plur	_	_	_	_
34	on	on	ADP	IN	_	_	_	_	_
35	class	class	NOUN	NN	Number=Sing	_	_	_	_
36	I	I	PRON	PRP	Case=Nom|Number=Sing|Person=1|PronType=Prs	_	_	_	_
37	MHC	MHC	PROPN	NNP	Number=Sing	_	_	_	_
38	antigen	antigen	ADJ	JJ	Degree=Pos	_	_	_	_
39	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
40	on	on	ADP	IN	_	_	_	_	_
41	target	target	NOUN	NN	Number=Sing	_	_	_	_
42	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
43	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3278
# text = This differential effect of E1A expression on the cytolytic phenotypes of infected and stably transfected human cells suggests that human NK cells provide an effective immunologic barrier against the in vivo survival and neoplastic progression of E1A-immortalized cells that may emerge from the reservoir of persistently infected cells in the human host.
1	This	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
2	differential	differential	ADJ	JJ	Degree=Pos	_	_	_	_
3	effect	effect	NOUN	NN	Number=Sing	_	_	_	_
4	of	of	ADP	IN	_	_	_	_	_
5	E1	E1	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
6	A	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
7	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
8	on	on	ADP	IN	_	_	_	_	_
9	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
10	cytolytic	cytolytic	ADJ	JJ	Degree=Pos	_	_	_	_
11	phenotypes	phenotype	NOUN	NNS	Number=Plur	_	_	_	_
12	of	of	ADP	IN	_	_	_	_	_
13	infected	infect	ADJ	JJ	Degree=Pos	_	_	_	_
14	and	and	CCONJ	CC	_	_	_	_	_
15	stably	stably	ADV	RB	_	_	_	_	_
16	transfected	transfect	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
17	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
18	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
19	suggests	suggest	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
20	that	that	SCONJ	IN	_	_	_	_	_
21	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
22	NK	NK	PROPN	NNP	Number=Sing	_	_	_	_
23	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
24	provide	provide	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
25	an	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
26	effective	effective	ADJ	JJ	Degree=Pos	_	_	_	_
27	immunologic	immunologic	ADJ	JJ	Degree=Pos	_	_	_	_
28	barrier	barrier	NOUN	NN	Number=Sing	_	_	_	_
29	against	against	ADP	IN	_	_	_	_	_
30	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
31	in	in	ADP	IN	_	_	_	_	_
32	vivo	vivo	NOUN	NN	Number=Sing	_	_	_	_
33	survival	survival	NOUN	NN	Number=Sing	_	_	_	_
34	and	and	CCONJ	CC	_	_	_	_	_
35	neoplastic	neoplastic	ADJ	JJ	Degree=Pos	_	_	_	_
36	progression	progression	NOUN	NN	Number=Sing	_	_	_	_
37	of	of	ADP	IN	_	_	_	_	_
38	E1A	E1A	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
39	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
40	immortalized	immortalize	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
41	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
42	that	that	PRON	WDT	PronType=Rel	_	_	_	_
43	may	may	AUX	MD	VerbForm=Fin	_	_	_	_
44	emerge	emerge	VERB	VB	VerbForm=Inf	_	_	_	_
45	from	from	ADP	IN	_	_	_	_	_
46	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
47	reservoir	reservoir	NOUN	NN	Number=Sing	_	_	_	_
48	of	of	ADP	IN	_	_	_	_	_
49	persistently	persistently	ADV	RB	_	_	_	_	_
50	infected	infect	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
51	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
52	in	in	ADP	IN	_	_	_	_	_
53	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
54	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
55	host	host	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
56	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 3279
# text = Document 003003434 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	003003434	003003434	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 3280
# text = Inhibition of the differentiation of human myeloid cell lines by redox changes induced through glutathione depletion.
1	Inhibition	Inhibition	NOUN	NN	Number=Sing	_	_	_	_
2	of	of	ADP	IN	_	_	_	_	_
3	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
4	differentiation	differentiation	NOUN	NN	Number=Sing	_	_	_	_
5	of	of	ADP	IN	_	_	_	_	_
6	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
7	myeloid	myeloid	ADJ	JJ	Degree=Pos	_	_	_	_
8	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
9	lines	line	NOUN	NNS	Number=Plur	_	_	_	_
10	by	by	ADP	IN	_	_	_	_	_
11	redox	redox	NOUN	NN	Number=Sing	_	_	_	_
12	changes	change	NOUN	NNS	Number=Plur	_	_	_	_
13	induced	induce	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
14	through	through	ADP	IN	_	_	_	_	_
15	glutathione	glutathione	NOUN	NN	Number=Sing	_	_	_	_
16	depletion	depletion	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
17	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 3281
# text = We have investigated the effect of redox changes in vivo on the differentiation of two human myeloid cell lines, HL-60 and KG-1.
1	We	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
2	have	have	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
3	investigated	investigate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
4	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
5	effect	effect	NOUN	NN	Number=Sing	_	_	_	_
6	of	of	ADP	IN	_	_	_	_	_
7	redox	redox	NOUN	NN	Number=Sing	_	_	_	_
8	changes	change	NOUN	NNS	Number=Plur	_	_	_	_
9	in	in	ADP	IN	_	_	_	_	_
10	vivo	vivo	NOUN	NN	Number=Sing	_	_	_	_
11	on	on	ADP	IN	_	_	_	_	_
12	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
13	differentiation	differentiation	NOUN	NN	Number=Sing	_	_	_	_
14	of	of	ADP	IN	_	_	_	_	_
15	two	two	NUM	CD	NumType=Card	_	_	_	_
16	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
17	myeloid	myeloid	NOUN	NN	Number=Sing	_	_	_	_
18	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
19	lines	line	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
20	,	,	PUNCT	,	_	_	_	_	_
21	HL	HL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
22	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
23	60	60	NUM	CD	NumType=Card	_	_	_	_
24	and	and	CCONJ	CC	_	_	_	_	_
25	KG	kg	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
26	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
27	1	1	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
28	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3282
# text = The glutathione-depleting agent diethyl maleate (DEM) prevented the development of differentiated features in response to phorbol esters, including adherence of the cells to plastic surfaces and repression of the myeloperoxidase and CD34 genes.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	glutathione	glutathione	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
3	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
4	depleting	deplet	NOUN	NN	Number=Sing	_	_	_	_
5	agent	agent	NOUN	NN	Number=Sing	_	_	_	_
6	diethyl	diethyl	NOUN	NN	Number=Sing	_	_	_	_
7	maleate	maleate	NOUN	NN	Number=Sing	_	_	_	_
8	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
9	DEM	DEM	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
10	)	)	PUNCT	-RRB-	_	_	_	_	_
11	prevented	prevent	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
12	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
13	development	development	NOUN	NN	Number=Sing	_	_	_	_
14	of	of	ADP	IN	_	_	_	_	_
15	differentiated	differentiate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
16	features	feature	NOUN	NNS	Number=Plur	_	_	_	_
17	in	in	ADP	IN	_	_	_	_	_
18	response	response	NOUN	NN	Number=Sing	_	_	_	_
19	to	to	PART	TO	_	_	_	_	_
20	phorbol	phorbol	VERB	VB	VerbForm=Inf	_	_	_	_
21	esters	ester	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
22	,	,	PUNCT	,	_	_	_	_	_
23	including	include	VERB	VBG	VerbForm=Ger	_	_	_	_
24	adherence	adherence	NOUN	NN	Number=Sing	_	_	_	_
25	of	of	ADP	IN	_	_	_	_	_
26	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
27	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
28	to	to	ADP	IN	_	_	_	_	_
29	plastic	plastic	ADJ	JJ	Degree=Pos	_	_	_	_
30	surfaces	surface	NOUN	NNS	Number=Plur	_	_	_	_
31	and	and	CCONJ	CC	_	_	_	_	_
32	repression	repression	NOUN	NN	Number=Sing	_	_	_	_
33	of	of	ADP	IN	_	_	_	_	_
34	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
35	myeloperoxidase	myeloperoxidase	NOUN	NN	Number=Sing	_	_	_	_
36	and	and	CCONJ	CC	_	_	_	_	_
37	CD34	Cd34	NOUN	NN	Number=Sing	_	_	_	_
38	genes	gene	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
39	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3283
# text = Moreover, DEM abolished phorbol 12-myristate 13-acetate-induced activation of the transcription factors AP-1 and Egr-1, suggesting that inhibition of differentiation may be due, at least in part, to redox modifications of these proteins.
1	Moreover	moreover	ADV	RB	_	_	_	_	SpaceAfter=No
2	,	,	PUNCT	,	_	_	_	_	_
3	DEM	DEM	PROPN	NNP	Number=Sing	_	_	_	_
4	abolished	abolish	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
5	phorbol	phorbol	NOUN	NN	Number=Sing	_	_	_	_
6	12	12	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
7	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
8	myristate	myristate	NOUN	NN	Number=Sing	_	_	_	_
9	13	13	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
10	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
11	acetate	acetate	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
12	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
13	induced	induce	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
14	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
15	of	of	ADP	IN	_	_	_	_	_
16	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
17	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
18	factors	factor	NOUN	NNS	Number=Plur	_	_	_	_
19	AP	ap	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
20	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
21	1	1	NUM	CD	NumType=Card	_	_	_	_
22	and	and	CCONJ	CC	_	_	_	_	_
23	Egr	Egr	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
24	-1	-1	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
25	,	,	PUNCT	,	_	_	_	_	_
26	suggesting	suggest	VERB	VBG	VerbForm=Ger	_	_	_	_
27	that	that	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
28	inhibition	inhibition	NOUN	NN	Number=Sing	_	_	_	_
29	of	of	ADP	IN	_	_	_	_	_
30	differentiation	differentiation	NOUN	NN	Number=Sing	_	_	_	_
31	may	may	AUX	MD	VerbForm=Fin	_	_	_	_
32	be	be	AUX	VB	VerbForm=Inf	_	_	_	_
33	due	due	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
34	,	,	PUNCT	,	_	_	_	_	_
35	at	at	ADV	RB	_	_	_	_	_
36	least	least	ADV	RBS	Degree=Sup	_	_	_	_
37	in	in	ADP	IN	_	_	_	_	_
38	part	part	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
39	,	,	PUNCT	,	_	_	_	_	_
40	to	to	PART	TO	_	_	_	_	_
41	redox	redox	VERB	VB	VerbForm=Inf	_	_	_	_
42	modifications	modification	NOUN	NNS	Number=Plur	_	_	_	_
43	of	of	ADP	IN	_	_	_	_	_
44	these	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
45	proteins	protein	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
46	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 3284
# text = Document 003003436 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	003003436	003003436	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 3285
# text = A new member of the leucine zipper class of proteins that binds to the HLA DR alpha promoter.
1	A	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
2	new	new	ADJ	JJ	Degree=Pos	_	_	_	_
3	member	member	NOUN	NN	Number=Sing	_	_	_	_
4	of	of	ADP	IN	_	_	_	_	_
5	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
6	leucine	leucine	NOUN	NN	Number=Sing	_	_	_	_
7	zipper	zipper	NOUN	NN	Number=Sing	_	_	_	_
8	class	class	NOUN	NN	Number=Sing	_	_	_	_
9	of	of	ADP	IN	_	_	_	_	_
10	proteins	protein	NOUN	NNS	Number=Plur	_	_	_	_
11	that	that	PRON	WDT	PronType=Rel	_	_	_	_
12	binds	bind	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
13	to	to	ADP	IN	_	_	_	_	_
14	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
15	HLA	HLA	PROPN	NNP	Number=Sing	_	_	_	_
16	DR	Dr	PROPN	NNP	Number=Sing	_	_	_	_
17	alpha	alpha	ADP	IN	_	_	_	_	_
18	promoter	promoter	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
19	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 3286
# text = Several mutants derived from transformed human B cell lines are defective in expressing major histocompatibility complex (MHC) class II genes.
1	Several	several	ADJ	JJ	Degree=Pos	_	_	_	_
2	mutants	mutant	NOUN	NNS	Number=Plur	_	_	_	_
3	derived	derive	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
4	from	from	ADP	IN	_	_	_	_	_
5	transformed	transform	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
6	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
7	B	b	NOUN	NN	Number=Sing	_	_	_	_
8	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
9	lines	line	NOUN	NNS	Number=Plur	_	_	_	_
10	are	be	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
11	defective	defective	ADJ	JJ	Degree=Pos	_	_	_	_
12	in	in	SCONJ	IN	_	_	_	_	_
13	expressing	expresse	VERB	VBG	VerbForm=Ger	_	_	_	_
14	major	major	ADJ	JJ	Degree=Pos	_	_	_	_
15	histocompatibility	histocompatibility	NOUN	NN	Number=Sing	_	_	_	_
16	complex	complex	NOUN	NN	Number=Sing	_	_	_	_
17	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
18	MHC	MHC	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
19	)	)	PUNCT	-RRB-	_	_	_	_	_
20	class	class	NOUN	NN	Number=Sing	_	_	_	_
21	II	ii	NUM	CD	NumType=Card	_	_	_	_
22	genes	gene	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
23	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3287
# text = The failure to express a class II gene in at least one such mutant line has been mapped to the MHC class II X box, a conserved transcriptional element in the promoter region.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	failure	failure	NOUN	NN	Number=Sing	_	_	_	_
3	to	to	PART	TO	_	_	_	_	_
4	express	express	VERB	VB	VerbForm=Inf	_	_	_	_
5	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
6	class	class	NOUN	NN	Number=Sing	_	_	_	_
7	II	ii	NUM	CD	NumType=Card	_	_	_	_
8	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
9	in	in	ADP	IN	_	_	_	_	_
10	at	at	ADV	RB	_	_	_	_	_
11	least	least	ADV	RBS	Degree=Sup	_	_	_	_
12	one	one	NUM	CD	NumType=Card	_	_	_	_
13	such	such	ADJ	JJ	Degree=Pos	_	_	_	_
14	mutant	mutant	ADJ	JJ	Degree=Pos	_	_	_	_
15	line	line	NOUN	NN	Number=Sing	_	_	_	_
16	has	have	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
17	been	be	AUX	VBN	Tense=Past|VerbForm=Part	_	_	_	_
18	mapped	map	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
19	to	to	ADP	IN	_	_	_	_	_
20	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
21	MHC	MHC	PROPN	NNP	Number=Sing	_	_	_	_
22	class	class	NOUN	NN	Number=Sing	_	_	_	_
23	II	ii	NUM	CD	NumType=Card	_	_	_	_
24	X	x	NOUN	NN	Number=Sing	_	_	_	_
25	box	box	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
26	,	,	PUNCT	,	_	_	_	_	_
27	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
28	conserved	conserve	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
29	transcriptional	transcriptional	ADJ	JJ	Degree=Pos	_	_	_	_
30	element	element	NOUN	NN	Number=Sing	_	_	_	_
31	in	in	ADP	IN	_	_	_	_	_
32	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
33	promoter	promoter	NOUN	NN	Number=Sing	_	_	_	_
34	region	region	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
35	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3288
# text = A complementary DNA encoding a DNA-binding protein (human X box binding protein, hXBP-1) whose target is the human DR alpha X box and the 3' flanking region has now been cloned.
1	A	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
2	complementary	complementary	ADJ	JJ	Degree=Pos	_	_	_	_
3	DNA	dna	NOUN	NN	Number=Sing	_	_	_	_
4	encoding	encod	VERB	VBG	VerbForm=Ger	_	_	_	_
5	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
6	DNA	dna	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
7	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
8	binding	bind	VERB	VBG	VerbForm=Ger	_	_	_	_
9	protein	protein	NOUN	NN	Number=Sing	_	_	_	_
10	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
11	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
12	X	x	NOUN	NN	Number=Sing	_	_	_	_
13	box	box	NOUN	NN	Number=Sing	_	_	_	_
14	binding	binding	VERB	VBG	VerbForm=Ger	_	_	_	_
15	protein	protein	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
16	,	,	PUNCT	,	_	_	_	_	_
17	hXBP	hXBP	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
18	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
19	1	1	X	LS	_	_	_	_	SpaceAfter=No
20	)	)	PUNCT	-RRB-	_	_	_	_	_
21	whose	whose	PRON	WP$	Poss=Yes|PronType=Int	_	_	_	_
22	target	target	NOUN	NN	Number=Sing	_	_	_	_
23	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
24	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
25	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
26	DR	Dr	NOUN	NN	Number=Sing	_	_	_	_
27	alpha	alpha	NOUN	NN	Number=Sing	_	_	_	_
28	X	x	SYM	SYM	_	_	_	_	_
29	box	box	NOUN	NN	Number=Sing	_	_	_	_
30	and	and	CCONJ	CC	_	_	_	_	_
31	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
32	3	3	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
33	'	'	PUNCT	``	_	_	_	_	_
34	flanking	flank	NOUN	NN	Number=Sing	_	_	_	_
35	region	region	NOUN	NN	Number=Sing	_	_	_	_
36	has	have	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
37	now	now	ADV	RB	_	_	_	_	_
38	been	be	AUX	VBN	Tense=Past|VerbForm=Part	_	_	_	_
39	cloned	clon	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	SpaceAfter=No
40	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3289
# text = This complementary DNA encoded a protein with structural similarities to the c-jun proto-oncogene product, and its target sequence was closely related to the palindromic target sequence of c-jun.
1	This	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
2	complementary	complementary	ADJ	JJ	Degree=Pos	_	_	_	_
3	DNA	dna	NOUN	NN	Number=Sing	_	_	_	_
4	encoded	encode	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
5	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
6	protein	protein	NOUN	NN	Number=Sing	_	_	_	_
7	with	with	ADP	IN	_	_	_	_	_
8	structural	structural	ADJ	JJ	Degree=Pos	_	_	_	_
9	similarities	similarity	NOUN	NNS	Number=Plur	_	_	_	_
10	to	to	ADP	IN	_	_	_	_	_
11	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
12	c-	c-	SYM	NFP	_	_	_	_	SpaceAfter=No
13	jun	jun	NOUN	NN	Number=Sing	_	_	_	_
14	proto	proto	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
15	-oncogene	-oncogene	NOUN	NN	Number=Sing	_	_	_	_
16	product	product	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
17	,	,	PUNCT	,	_	_	_	_	_
18	and	and	CCONJ	CC	_	_	_	_	_
19	it	it	PRON	PRP	Case=Nom|Gender=Neut|Number=Sing|Person=3|PronType=Prs	_	_	_	SpaceAfter=No
20	s	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
21	target	target	NOUN	NN	Number=Sing	_	_	_	_
22	sequence	sequence	NOUN	NN	Number=Sing	_	_	_	_
23	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
24	closely	closely	ADV	RB	_	_	_	_	_
25	related	related	ADJ	JJ	Degree=Pos	_	_	_	_
26	to	to	ADP	IN	_	_	_	_	_
27	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
28	palindromic	palindromic	ADJ	JJ	Degree=Pos	_	_	_	_
29	target	target	NOUN	NN	Number=Sing	_	_	_	_
30	sequence	sequence	NOUN	NN	Number=Sing	_	_	_	_
31	of	of	ADP	IN	_	_	_	_	_
32	c-	c-	SYM	NFP	_	_	_	_	SpaceAfter=No
33	jun	jun	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
34	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3290
# text = Mutation of the hXBP-1 DNA target sequence decreased DR alpha promoter activity in vivo.
1	Mutation	Mutation	NOUN	NN	Number=Sing	_	_	_	_
2	of	of	ADP	IN	_	_	_	_	_
3	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
4	hXBP	hxbp	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
5	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
6	1	1	NUM	CD	NumType=Card	_	_	_	_
7	DNA	dna	NOUN	NN	Number=Sing	_	_	_	_
8	target	target	NOUN	NN	Number=Sing	_	_	_	_
9	sequence	sequence	NOUN	NN	Number=Sing	_	_	_	_
10	decreased	decrease	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
11	DR	Dr	PROPN	NNP	Number=Sing	_	_	_	_
12	alpha	alpha	ADP	IN	_	_	_	_	_
13	promoter	promoter	NOUN	NN	Number=Sing	_	_	_	_
14	activity	activity	NOUN	NN	Number=Sing	_	_	_	_
15	in	in	ADP	IN	_	_	_	_	_
16	vivo	vivo	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
17	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3291
# text = These studies suggest that the hXBP-1 protein acts as a transcription factor in B cells.
1	These	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
2	studies	study	NOUN	NNS	Number=Plur	_	_	_	_
3	suggest	suggest	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
4	that	that	SCONJ	IN	_	_	_	_	_
5	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
6	hXBP	hxbp	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
7	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
8	1	1	NUM	CD	NumType=Card	_	_	_	_
9	protein	protein	NOUN	NN	Number=Sing	_	_	_	_
10	acts	act	NOUN	NNS	Number=Plur	_	_	_	_
11	as	as	ADP	IN	_	_	_	_	_
12	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
13	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
14	factor	factor	NOUN	NN	Number=Sing	_	_	_	_
15	in	in	ADP	IN	_	_	_	_	_
16	B	b	ADJ	JJ	Degree=Pos	_	_	_	_
17	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
18	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 3292
# text = Document 003003437 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	003003437	003003437	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 3293
# text = Binding characteristics of the glucocorticoid receptor in peripheral blood lymphocytes in multiple sclerosis.
1	Binding	bind	VERB	VBG	VerbForm=Ger	_	_	_	_
2	characteristics	characteristic	NOUN	NNS	Number=Plur	_	_	_	_
3	of	of	ADP	IN	_	_	_	_	_
4	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
5	glucocorticoid	glucocorticoid	ADJ	JJ	Degree=Pos	_	_	_	_
6	receptor	receptor	NOUN	NN	Number=Sing	_	_	_	_
7	in	in	ADP	IN	_	_	_	_	_
8	peripheral	peripheral	ADJ	JJ	Degree=Pos	_	_	_	_
9	blood	blood	NOUN	NN	Number=Sing	_	_	_	_
10	lymphocytes	lymphocyte	NOUN	NNS	Number=Plur	_	_	_	_
11	in	in	ADP	IN	_	_	_	_	_
12	multiple	multiple	ADJ	JJ	Degree=Pos	_	_	_	_
13	sclerosis	sclerosis	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
14	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 3294
# text = Although the exact etiology of multiple sclerosis (MS) remains unresolved, immune reactions are believed to be the central pathogenic mechanisms.
1	Although	although	SCONJ	IN	_	_	_	_	_
2	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
3	exact	exact	ADJ	JJ	Degree=Pos	_	_	_	_
4	etiology	etiology	NOUN	NN	Number=Sing	_	_	_	_
5	of	of	ADP	IN	_	_	_	_	_
6	multiple	multiple	ADJ	JJ	Degree=Pos	_	_	_	_
7	sclerosis	sclerosis	NOUN	NN	Number=Sing	_	_	_	_
8	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
9	MS	MS	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
10	)	)	PUNCT	-RRB-	_	_	_	_	_
11	remains	remain	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
12	unresolved	unresolved	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
13	,	,	PUNCT	,	_	_	_	_	_
14	immune	immune	ADJ	JJ	Degree=Pos	_	_	_	_
15	reactions	reaction	NOUN	NNS	Number=Plur	_	_	_	_
16	are	be	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
17	believed	believe	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
18	to	to	PART	TO	_	_	_	_	_
19	be	be	AUX	VB	VerbForm=Inf	_	_	_	_
20	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
21	central	central	ADJ	JJ	Degree=Pos	_	_	_	_
22	pathogenic	pathogenic	NOUN	NN	Number=Sing	_	_	_	_
23	mechanisms	mechanism	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
24	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3295
# text = Endogenous and therapeutic steroid hormones affect the immune system, and inflammatory diseases are associated with activation of the hypothalamic-pituitary-adrenal axis, providing evidence of an immune-endocrine interplay.
1	Endogenous	Endogenous	ADJ	JJ	Degree=Pos	_	_	_	_
2	and	and	CCONJ	CC	_	_	_	_	_
3	therapeutic	therapeutic	ADJ	JJ	Degree=Pos	_	_	_	_
4	steroid	steroid	ADJ	JJ	Degree=Pos	_	_	_	_
5	hormones	hormone	NOUN	NNS	Number=Plur	_	_	_	_
6	affect	affect	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
7	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
8	immune	immune	ADJ	JJ	Degree=Pos	_	_	_	_
9	system	system	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
10	,	,	PUNCT	,	_	_	_	_	_
11	and	and	CCONJ	CC	_	_	_	_	_
12	inflammatory	inflammatory	ADJ	JJ	Degree=Pos	_	_	_	_
13	diseases	diseasis	NOUN	NNS	Number=Plur	_	_	_	_
14	are	be	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
15	associated	associate	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
16	with	with	ADP	IN	_	_	_	_	_
17	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
18	of	of	ADP	IN	_	_	_	_	_
19	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
20	hypothalamic	hypothalamic	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
21	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
22	pituitary	pituitary	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
23	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
24	adrenal	adrenal	ADJ	JJ	Degree=Pos	_	_	_	_
25	axis	axis	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
26	,	,	PUNCT	,	_	_	_	_	_
27	providing	provid	VERB	VBG	VerbForm=Ger	_	_	_	_
28	evidence	evidence	NOUN	NN	Number=Sing	_	_	_	_
29	of	of	ADP	IN	_	_	_	_	_
30	an	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
31	immune	immune	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
32	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
33	endocrine	endocrine	NOUN	NN	Number=Sing	_	_	_	_
34	interplay	interplay	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
35	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3296
# text = Function tests in MS have revealed dysregulation of the hypothalamic-pituitary-adrenal system in a substantial proportion of patients.
1	Function	function	NOUN	NN	Number=Sing	_	_	_	_
2	tests	test	NOUN	NNS	Number=Plur	_	_	_	_
3	in	in	ADP	IN	_	_	_	_	_
4	MS	MS	NOUN	NNS	Number=Plur	_	_	_	_
5	have	have	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
6	revealed	reveal	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
7	dysregulation	dysregulation	NOUN	NN	Number=Sing	_	_	_	_
8	of	of	ADP	IN	_	_	_	_	_
9	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
10	hypothalamic	hypothalamic	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
11	-pituitary-adrenal	-pituitary-adrenal	ADJ	JJ	Degree=Pos	_	_	_	_
12	system	system	NOUN	NN	Number=Sing	_	_	_	_
13	in	in	ADP	IN	_	_	_	_	_
14	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
15	substantial	substantial	ADJ	JJ	Degree=Pos	_	_	_	_
16	proportion	proportion	NOUN	NN	Number=Sing	_	_	_	_
17	of	of	ADP	IN	_	_	_	_	_
18	patients	patient	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
19	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3297
# text = We characterized glucocorticoid receptor (GR) binding in peripheral blood lymphocytes from 39 MS patients and 14 age- and sex-matched controls with respect to dissociation constant and binding capacity, using a whole-cell binding assay with [3H]dexamethasone as the ligand.
1	We	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
2	characterized	characterize	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
3	glucocorticoid	glucocorticoid	ADJ	JJ	Degree=Pos	_	_	_	_
4	receptor	receptor	NOUN	NN	Number=Sing	_	_	_	_
5	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
6	GR	GR	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
7	)	)	PUNCT	-RRB-	_	_	_	_	_
8	binding	bind	VERB	VBG	VerbForm=Ger	_	_	_	_
9	in	in	ADP	IN	_	_	_	_	_
10	peripheral	peripheral	ADJ	JJ	Degree=Pos	_	_	_	_
11	blood	blood	NOUN	NN	Number=Sing	_	_	_	_
12	lymphocytes	lymphocyte	NOUN	NNS	Number=Plur	_	_	_	_
13	from	from	ADP	IN	_	_	_	_	_
14	39	39	NUM	CD	NumType=Card	_	_	_	_
15	MS	MS	PROPN	NNP	Number=Sing	_	_	_	_
16	patients	patient	NOUN	NNS	Number=Plur	_	_	_	_
17	and	and	CCONJ	CC	_	_	_	_	_
18	14	14	NUM	CD	NumType=Card	_	_	_	_
19	age	age	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
20	-	-	PUNCT	,	_	_	_	_	_
21	and	and	CCONJ	CC	_	_	_	_	_
22	sex	sex	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
23	-matched	-matched	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
24	controls	control	NOUN	NNS	Number=Plur	_	_	_	_
25	with	with	ADP	IN	_	_	_	_	_
26	respect	respect	NOUN	NN	Number=Sing	_	_	_	_
27	to	to	ADP	IN	_	_	_	_	_
28	dissociation	dissociation	NOUN	NN	Number=Sing	_	_	_	_
29	constant	constant	NOUN	NN	Number=Sing	_	_	_	_
30	and	and	CCONJ	CC	_	_	_	_	_
31	binding	binde	VERB	VBG	VerbForm=Ger	_	_	_	_
32	capacity	capacity	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
33	,	,	PUNCT	,	_	_	_	_	_
34	using	use	VERB	VBG	VerbForm=Ger	_	_	_	_
35	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
36	whole	whole	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
37	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
38	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
39	binding	binding	VERB	VBG	VerbForm=Ger	_	_	_	_
40	assay	assay	ADV	RB	_	_	_	_	_
41	with	with	ADP	IN	_	_	_	_	_
42	[	[	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
43	3H	3H	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
44	]	]	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
45	dexamethasone	dexamethasone	NOUN	NN	Number=Sing	_	_	_	_
46	as	as	ADP	IN	_	_	_	_	_
47	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
48	ligand	ligand	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
49	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3298
# text = GR binding parameters did not differ significantly between patients (Kd 8.98 +/- 1.07 nM, Bmax 183 +/- 29.8 fmol/mg) and controls (Kd 9.36 +/- 1.17 nM, Bmax 158 +/- 16 fmol/mg).
1	GR	Gr	VERB	VB	Mood=Imp|VerbForm=Fin	_	_	_	_
2	binding	binding	VERB	VBG	VerbForm=Ger	_	_	_	_
3	parameters	parameter	NOUN	NNS	Number=Plur	_	_	_	_
4	did	do	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
5	not	not	PART	RB	_	_	_	_	_
6	differ	differ	VERB	VB	VerbForm=Inf	_	_	_	_
7	significantly	significantly	ADV	RB	_	_	_	_	_
8	between	between	ADP	IN	_	_	_	_	_
9	patients	patient	NOUN	NNS	Number=Plur	_	_	_	_
10	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
11	Kd	K	PROPN	NNP	Number=Sing	_	_	_	_
12	8.98	8.98	NUM	CD	NumType=Card	_	_	_	_
13	+/-	+/-	SYM	SYM	_	_	_	_	_
14	1.07	1.07	NUM	CD	NumType=Card	_	_	_	_
15	nM	nm	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
16	,	,	PUNCT	,	_	_	_	_	_
17	Bmax	Bmax	PROPN	NNP	Number=Sing	_	_	_	_
18	183	183	NUM	CD	NumType=Card	_	_	_	_
19	+/-	+/-	SYM	SYM	_	_	_	_	_
20	29.8	29.8	NUM	CD	NumType=Card	_	_	_	_
21	fmol	fmol	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
22	/	/	PUNCT	,	_	_	_	_	SpaceAfter=No
23	mg	mg	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
24	)	)	PUNCT	-RRB-	_	_	_	_	_
25	and	and	CCONJ	CC	_	_	_	_	_
26	controls	controls	NOUN	NNS	Number=Plur	_	_	_	_
27	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
28	Kd	K	PROPN	NNP	Number=Sing	_	_	_	_
29	9.36	9.36	NUM	CD	NumType=Card	_	_	_	_
30	+/-	+/-	SYM	SYM	_	_	_	_	_
31	1.17	1.17	NUM	CD	NumType=Card	_	_	_	_
32	nM	nm	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
33	,	,	PUNCT	,	_	_	_	_	_
34	Bmax	Bmax	PROPN	NNP	Number=Sing	_	_	_	_
35	158	158	NUM	CD	NumType=Card	_	_	_	_
36	+/-	+/-	SYM	SYM	_	_	_	_	_
37	16	16	NUM	CD	NumType=Card	_	_	_	_
38	fmol	fmol	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
39	/	/	PUNCT	,	_	_	_	_	SpaceAfter=No
40	mg	mg	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
41	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
42	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3299
# text = No effect of age, sex, course, duration or severity of disease, or prior steroid treatments was detected.
1	No	no	DET	DT	_	_	_	_	_
2	effect	effect	NOUN	NN	Number=Sing	_	_	_	_
3	of	of	ADP	IN	_	_	_	_	_
4	age	age	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
5	,	,	PUNCT	,	_	_	_	_	_
6	sex	sex	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
7	,	,	PUNCT	,	_	_	_	_	_
8	course	course	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
9	,	,	PUNCT	,	_	_	_	_	_
10	duration	duration	NOUN	NN	Number=Sing	_	_	_	_
11	or	or	CCONJ	CC	_	_	_	_	_
12	severity	severity	NOUN	NN	Number=Sing	_	_	_	_
13	of	of	ADP	IN	_	_	_	_	_
14	disease	disease	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
15	,	,	PUNCT	,	_	_	_	_	_
16	or	or	CCONJ	CC	_	_	_	_	_
17	prior	prior	ADJ	JJ	Degree=Pos	_	_	_	_
18	steroid	steroid	ADJ	JJ	Degree=Pos	_	_	_	_
19	treatments	treatment	NOUN	NNS	Number=Plur	_	_	_	_
20	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
21	detected	detect	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	SpaceAfter=No
22	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3300
# text = GR binding parameters were analyzed in relation to the results of the combined dexamethasone-CRH test, which reflects corticosteroid receptor function at the hypothalamus, in 30 patients and 9 controls.
1	GR	Gr	VERB	VB	Mood=Imp|VerbForm=Fin	_	_	_	_
2	binding	binding	VERB	VBG	VerbForm=Ger	_	_	_	_
3	parameters	parameter	NOUN	NNS	Number=Plur	_	_	_	_
4	were	be	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
5	analyzed	analyze	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
6	in	in	ADP	IN	_	_	_	_	_
7	relation	relation	NOUN	NN	Number=Sing	_	_	_	_
8	to	to	ADP	IN	_	_	_	_	_
9	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
10	results	result	NOUN	NNS	Number=Plur	_	_	_	_
11	of	of	ADP	IN	_	_	_	_	_
12	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
13	combined	combine	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
14	dexamethasone	dexamethasone	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
15	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
16	CRH	CRh	NOUN	NN	Number=Sing	_	_	_	_
17	test	test	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
18	,	,	PUNCT	,	_	_	_	_	_
19	which	which	PRON	WDT	PronType=Rel	_	_	_	_
20	reflects	reflect	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
21	corticosteroid	corticosteroid	ADJ	JJ	Degree=Pos	_	_	_	_
22	receptor	receptor	NOUN	NN	Number=Sing	_	_	_	_
23	function	function	NOUN	NN	Number=Sing	_	_	_	_
24	at	at	ADP	IN	_	_	_	_	_
25	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
26	hypothalamus	hypothalamus	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
27	,	,	PUNCT	,	_	_	_	_	_
28	in	in	ADP	IN	_	_	_	_	_
29	30	30	NUM	CD	NumType=Card	_	_	_	_
30	patients	patient	NOUN	NNS	Number=Plur	_	_	_	_
31	and	and	CCONJ	CC	_	_	_	_	_
32	9	9	NUM	CD	NumType=Card	_	_	_	_
33	controls	control	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
34	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3301
# text = While controls showed a moderate correlation between binding affinity of the GR in lymphocytes and regulatory function at the hypothalamic level, the patients did not.
1	While	while	SCONJ	IN	_	_	_	_	_
2	controls	control	NOUN	NNS	Number=Plur	_	_	_	_
3	showed	show	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
4	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
5	moderate	moderate	ADJ	JJ	Degree=Pos	_	_	_	_
6	correlation	correlation	NOUN	NN	Number=Sing	_	_	_	_
7	between	between	ADP	IN	_	_	_	_	_
8	binding	bind	VERB	VBG	VerbForm=Ger	_	_	_	_
9	affinity	affinity	NOUN	NN	Number=Sing	_	_	_	_
10	of	of	ADP	IN	_	_	_	_	_
11	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
12	GR	Gr	NOUN	NN	Number=Sing	_	_	_	_
13	in	in	ADP	IN	_	_	_	_	_
14	lymphocytes	lymphocyte	NOUN	NNS	Number=Plur	_	_	_	_
15	and	and	CCONJ	CC	_	_	_	_	_
16	regulatory	regulatory	ADJ	JJ	Degree=Pos	_	_	_	_
17	function	function	NOUN	NN	Number=Sing	_	_	_	_
18	at	at	ADP	IN	_	_	_	_	_
19	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
20	hypothalamic	hypothalamic	ADJ	JJ	Degree=Pos	_	_	_	_
21	level	level	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
22	,	,	PUNCT	,	_	_	_	_	_
23	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
24	patients	patient	NOUN	NNS	Number=Plur	_	_	_	_
25	did	do	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
26	not	not	PART	RB	_	_	_	_	SpaceAfter=No
27	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3302
# text = These data suggest that the physiological relationship between binding and function of the glucocorticoid receptor is disturbed in MS.
1	These	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
2	data	data	NOUN	NN	Number=Sing	_	_	_	_
3	suggest	suggest	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
4	that	that	SCONJ	IN	_	_	_	_	_
5	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
6	physiological	physiological	ADJ	JJ	Degree=Pos	_	_	_	_
7	relationship	relationship	NOUN	NN	Number=Sing	_	_	_	_
8	between	between	ADP	IN	_	_	_	_	_
9	binding	binding	NOUN	NN	Number=Sing	_	_	_	_
10	and	and	CCONJ	CC	_	_	_	_	_
11	function	function	NOUN	NN	Number=Sing	_	_	_	_
12	of	of	ADP	IN	_	_	_	_	_
13	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
14	glucocorticoid	glucocorticoid	ADJ	JJ	Degree=Pos	_	_	_	_
15	receptor	receptor	NOUN	NN	Number=Sing	_	_	_	_
16	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
17	disturbed	distur	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
18	in	in	ADP	IN	_	_	_	_	_
19	MS	MS	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
20	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 3303
# text = Document 003003438 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	003003438	003003438	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 3304
# text = Molecular mechanisms of steroid action: a novel type of cross-talk between glucocorticoids and NF-kappa B transcription factors.
1	Molecular	Molecular	ADJ	JJ	Degree=Pos	_	_	_	_
2	mechanisms	mechanism	NOUN	NNS	Number=Plur	_	_	_	_
3	of	of	ADP	IN	_	_	_	_	_
4	steroid	steroid	NOUN	NN	Number=Sing	_	_	_	_
5	action	action	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
6	:	:	PUNCT	:	_	_	_	_	_
7	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
8	novel	novel	NOUN	NN	Number=Sing	_	_	_	_
9	type	type	NOUN	NN	Number=Sing	_	_	_	_
10	of	of	ADP	IN	_	_	_	_	_
11	cross-talk	cross-talk	NOUN	NN	Number=Sing	_	_	_	_
12	between	between	ADP	IN	_	_	_	_	_
13	glucocorticoids	glucocorticoid	NOUN	NNS	Number=Plur	_	_	_	_
14	and	and	CCONJ	CC	_	_	_	_	_
15	NF	Nf	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
16	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
17	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_
18	B	b	NOUN	NN	Number=Sing	_	_	_	_
19	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
20	factors	factor	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
21	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 3305
# text = Despite the widespread use of glucocorticoids in the treatment of diseases characterized by inflammation, the molecular mechanism(s) by which these hormones exert this beneficial effect in patients with asthma remains to be elucidated.
1	Despite	despite	ADP	IN	_	_	_	_	_
2	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
3	widespread	widespread	ADJ	JJ	Degree=Pos	_	_	_	_
4	use	use	NOUN	NN	Number=Sing	_	_	_	_
5	of	of	ADP	IN	_	_	_	_	_
6	glucocorticoids	glucocorticoid	NOUN	NNS	Number=Plur	_	_	_	_
7	in	in	ADP	IN	_	_	_	_	_
8	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
9	treatment	treatment	NOUN	NN	Number=Sing	_	_	_	_
10	of	of	ADP	IN	_	_	_	_	_
11	diseases	diseasis	NOUN	NNS	Number=Plur	_	_	_	_
12	characterized	characterize	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
13	by	by	ADP	IN	_	_	_	_	_
14	inflammation	inflammation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
15	,	,	PUNCT	,	_	_	_	_	_
16	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
17	molecular	molecular	ADJ	JJ	Degree=Pos	_	_	_	_
18	mechanism	mechanism	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
19	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
20	s	s	X	AFX	_	_	_	_	SpaceAfter=No
21	)	)	PUNCT	-RRB-	_	_	_	_	_
22	by	by	ADP	IN	_	_	_	_	_
23	which	which	PRON	WDT	PronType=Rel	_	_	_	_
24	these	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
25	hormones	hormone	NOUN	NNS	Number=Plur	_	_	_	_
26	exert	exert	ADP	IN	Typo=Yes	_	_	_	_
27	this	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
28	beneficial	beneficial	ADJ	JJ	Degree=Pos	_	_	_	_
29	effect	effect	NOUN	NN	Number=Sing	_	_	_	_
30	in	in	ADP	IN	_	_	_	_	_
31	patients	patient	NOUN	NNS	Number=Plur	_	_	_	_
32	with	with	ADP	IN	_	_	_	_	_
33	asthma	asthma	NOUN	NN	Number=Sing	_	_	_	_
34	remains	remain	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
35	to	to	PART	TO	_	_	_	_	_
36	be	be	AUX	VB	VerbForm=Inf	_	_	_	_
37	elucidated	elucidate	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	SpaceAfter=No
38	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3306
# text = Therefore, we have studied the transcriptional regulation of intercellular adhesion molecule-1 (ICAM-1) as adhesion molecules are likely to play a causal role in inflammation in promoting cell-cell and cell-matrix interactions.
1	Therefore	therefore	ADV	RB	_	_	_	_	SpaceAfter=No
2	,	,	PUNCT	,	_	_	_	_	_
3	we	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
4	have	have	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
5	studied	studie	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
6	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
7	transcriptional	transcriptional	ADJ	JJ	Degree=Pos	_	_	_	_
8	regulation	regulation	NOUN	NN	Number=Sing	_	_	_	_
9	of	of	ADP	IN	_	_	_	_	_
10	intercellular	intercellular	ADJ	JJ	Degree=Pos	_	_	_	_
11	adhesion	adhesion	NOUN	NN	Number=Sing	_	_	_	_
12	molecule	molecule	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
13	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
14	1	1	NUM	CD	NumType=Card	_	_	_	_
15	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
16	ICAM	ICAm	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
17	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
18	1	1	X	LS	_	_	_	_	SpaceAfter=No
19	)	)	PUNCT	-RRB-	_	_	_	_	_
20	as	as	ADP	IN	_	_	_	_	_
21	adhesion	adhesion	NOUN	NN	Number=Sing	_	_	_	_
22	molecules	molecule	NOUN	NNS	Number=Plur	_	_	_	_
23	are	be	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
24	likely	likely	ADJ	JJ	Degree=Pos	_	_	_	_
25	to	to	PART	TO	_	_	_	_	_
26	play	play	VERB	VB	VerbForm=Inf	_	_	_	_
27	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
28	causal	causal	ADJ	JJ	Degree=Pos	_	_	_	_
29	role	role	NOUN	NN	Number=Sing	_	_	_	_
30	in	in	ADP	IN	_	_	_	_	_
31	inflammation	inflammation	NOUN	NN	Number=Sing	_	_	_	_
32	in	in	SCONJ	IN	_	_	_	_	_
33	promoting	promote	VERB	VBG	VerbForm=Ger	_	_	_	_
34	cell	cell	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
35	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
36	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
37	and	and	CCONJ	CC	_	_	_	_	_
38	cell	cell	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
39	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
40	matrix	matrix	NOUN	NN	Number=Sing	_	_	_	_
41	interactions	interaction	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
42	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3307
# text = We observed that in a monocytic (U937) and a bronchial epithelial (H292) cell-line dexamethasone strongly suppressed basal and induced ICAM-1 expression.
1	We	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
2	observed	observe	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
3	that	that	SCONJ	IN	_	_	_	_	_
4	in	in	ADP	IN	_	_	_	_	_
5	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
6	monocytic	monocytic	NOUN	NN	Number=Sing	_	_	_	_
7	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
8	U937	U937	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
9	)	)	PUNCT	-RRB-	_	_	_	_	_
10	and	and	CCONJ	CC	_	_	_	_	_
11	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
12	bronchial	bronchial	ADJ	JJ	Degree=Pos	_	_	_	_
13	epithelial	epithelial	NOUN	NN	Number=Sing	_	_	_	_
14	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
15	H292	H292	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
16	)	)	PUNCT	-RRB-	_	_	_	_	_
17	cell	cell	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
18	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
19	line	line	NOUN	NN	Number=Sing	_	_	_	_
20	dexamethasone	dexamethasone	NOUN	NN	Number=Sing	_	_	_	_
21	strongly	strongly	ADV	RB	_	_	_	_	_
22	suppressed	suppress	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
23	basal	basal	NOUN	NN	Number=Sing	_	_	_	_
24	and	and	CCONJ	CC	_	_	_	_	_
25	induced	induce	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
26	ICAM	ICAm	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
27	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
28	1	1	NUM	CD	NumType=Card	_	_	_	_
29	expression	expression	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
30	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3308
# text = Subsequent analysis of the human ICAM-1 promoter has revealed that both 12-O-tetradecanoylphorbol 13-acetate (TPA) and tumour necrosis factor-alpha (TNF-alpha) upregulate ICAM-1 expression through the presence of a nuclear factor (NF-kappa B) target sequence (TGGAAATTCC).
1	Subsequent	subsequent	ADJ	JJ	Degree=Pos	_	_	_	_
2	analysis	analysis	NOUN	NN	Number=Sing	_	_	_	_
3	of	of	ADP	IN	_	_	_	_	_
4	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
5	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
6	ICAM	ICAm	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
7	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
8	1	1	NUM	CD	NumType=Card	_	_	_	_
9	promoter	promoter	NOUN	NN	Number=Sing	_	_	_	_
10	has	have	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
11	revealed	reveal	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
12	that	that	SCONJ	IN	_	_	_	_	_
13	both	both	DET	DT	_	_	_	_	_
14	12	12	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
15	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
16	O	of	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
17	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
18	tetradecanoylphorbol	tetradecanoylphorbol	NOUN	NN	Number=Sing	_	_	_	_
19	13	13	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
20	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
21	acetate	acetate	NOUN	NN	Number=Sing	_	_	_	_
22	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
23	TPA	TPA	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
24	)	)	PUNCT	-RRB-	_	_	_	_	_
25	and	and	CCONJ	CC	_	_	_	_	_
26	tumour	tumour	PRON	PRP$	Number=Plur|Person=1|Poss=Yes|PronType=Prs	_	_	_	_
27	necrosis	necrosis	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
28	factor	factor	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
29	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
30	alpha	alpha	NOUN	NN	Number=Sing	_	_	_	_
31	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
32	TNF	Tnf	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
33	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
34	alpha	alpha	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
35	)	)	PUNCT	-RRB-	_	_	_	_	_
36	upregulate	upregulate	ADJ	JJ	Degree=Pos	_	_	_	_
37	ICAM	ICAM	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
38	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
39	1	1	NUM	CD	NumType=Card	_	_	_	_
40	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
41	through	through	ADP	IN	_	_	_	_	_
42	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
43	presence	presence	NOUN	NN	Number=Sing	_	_	_	_
44	of	of	ADP	IN	_	_	_	_	_
45	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
46	nuclear	nuclear	ADJ	JJ	Degree=Pos	_	_	_	_
47	factor	factor	NOUN	NN	Number=Sing	_	_	_	_
48	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
49	NF	Nf	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
50	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
51	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_
52	B	b	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
53	)	)	PUNCT	-RRB-	_	_	_	_	_
54	target	target	NOUN	NN	Number=Sing	_	_	_	_
55	sequence	sequence	NOUN	NN	Number=Sing	_	_	_	_
56	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
57	TGGAAATTCC	TGGAAATTCC	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
58	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
59	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3309
# text = No glucocorticoid recognition sequences are present in this promoter region and dexamethasone is still able to repress transcription when the multimerized NF-kappa B sequence is transactivated by TNF-alpha upon transfection in 293 cells.
1	No	no	DET	DT	_	_	_	_	_
2	glucocorticoid	glucocorticoid	NOUN	NN	Number=Sing	_	_	_	_
3	recognition	recognition	NOUN	NN	Number=Sing	_	_	_	_
4	sequences	sequence	NOUN	NNS	Number=Plur	_	_	_	_
5	are	be	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
6	present	presend	ADJ	JJ	Degree=Pos	_	_	_	_
7	in	in	ADP	IN	_	_	_	_	_
8	this	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
9	promoter	promoter	NOUN	NN	Number=Sing	_	_	_	_
10	region	region	NOUN	NN	Number=Sing	_	_	_	_
11	and	and	CCONJ	CC	_	_	_	_	_
12	dexamethasone	dexamethasone	NOUN	NN	Number=Sing	_	_	_	_
13	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
14	still	still	ADV	RB	_	_	_	_	_
15	able	able	ADJ	JJ	Degree=Pos	_	_	_	_
16	to	to	PART	TO	_	_	_	_	_
17	repress	repress	VERB	VB	VerbForm=Inf	_	_	_	_
18	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
19	when	when	ADV	WRB	PronType=Int	_	_	_	_
20	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
21	multimerized	multimerize	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
22	NF	Nf	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
23	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
24	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_
25	B	b	NOUN	NN	Number=Sing	_	_	_	_
26	sequence	sequence	NOUN	NN	Number=Sing	_	_	_	_
27	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
28	transactivated	transactivate	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
29	by	by	ADP	IN	_	_	_	_	_
30	TNF	TNF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
31	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
32	alpha	alpha	ADV	RB	_	_	_	_	_
33	upon	upon	ADP	IN	_	_	_	_	_
34	transfection	transfection	NOUN	NN	Number=Sing	_	_	_	_
35	in	in	ADP	IN	_	_	_	_	_
36	293	293	NUM	CD	NumType=Card	_	_	_	_
37	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
38	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3310
# text = We propose that direct interaction between the glucocorticoid receptor and nuclear factor-kappa B factors is at least a partial explanation for the effects of this hormone in inflammatory diseases.
1	We	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
2	propose	propose	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
3	that	that	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
4	direct	direct	ADJ	JJ	Degree=Pos	_	_	_	_
5	interaction	interaction	NOUN	NN	Number=Sing	_	_	_	_
6	between	between	ADP	IN	_	_	_	_	_
7	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
8	glucocorticoid	glucocorticoid	ADJ	JJ	Degree=Pos	_	_	_	_
9	receptor	receptor	NOUN	NN	Number=Sing	_	_	_	_
10	and	and	CCONJ	CC	_	_	_	_	_
11	nuclear	nuclear	ADJ	JJ	Degree=Pos	_	_	_	_
12	factor	factor	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
13	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
14	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_
15	B	b	NOUN	NN	Number=Sing	_	_	_	_
16	factors	factor	NOUN	NNS	Number=Plur	_	_	_	_
17	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
18	at	at	ADV	RB	_	_	_	_	_
19	least	least	ADV	RBS	Degree=Sup	_	_	_	_
20	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
21	partial	partial	ADJ	JJ	Degree=Pos	_	_	_	_
22	explanation	explanation	NOUN	NN	Number=Sing	_	_	_	_
23	for	for	ADP	IN	_	_	_	_	_
24	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
25	effects	effect	NOUN	NNS	Number=Plur	_	_	_	_
26	of	of	ADP	IN	_	_	_	_	_
27	this	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
28	hormone	hormone	NOUN	NN	Number=Sing	_	_	_	_
29	in	in	ADP	IN	_	_	_	_	_
30	inflammatory	inflammatory	ADJ	JJ	Degree=Pos	_	_	_	_
31	diseases	diseasis	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
32	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 3311
# text = Document 003003442 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	003003442	003003442	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 3312
# text = Epstein-Barr virus nuclear antigen 2 transactivates latent membrane protein LMP1.
1	Epstein	Epstein	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
2	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
3	Barr	Barr	PROPN	NNP	Number=Sing	_	_	_	_
4	virus	virus	NOUN	NN	Number=Sing	_	_	_	_
5	nuclear	nuclear	ADJ	JJ	Degree=Pos	_	_	_	_
6	antigen	antigen	ADJ	JJ	Degree=Pos	_	_	_	_
7	2	2	NUM	CD	NumType=Card	_	_	_	_
8	transactivates	transactivate	NOUN	NNS	Number=Plur	_	_	_	_
9	latent	latent	ADJ	JJ	Degree=Pos	_	_	_	_
10	membrane	membrane	NOUN	NN	Number=Sing	_	_	_	_
11	protein	protein	NOUN	NN	Number=Sing	_	_	_	_
12	LMP1	Lmp1	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
13	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 3313
# text = Several lines of evidence are compatible with the hypothesis that Epstein-Barr virus (EBV) nuclear antigen 2 (EBNA-2) or leader protein (EBNA-LP) affects expression of the EBV latent infection membrane protein LMP1.
1	Several	several	ADJ	JJ	Degree=Pos	_	_	_	_
2	lines	line	NOUN	NNS	Number=Plur	_	_	_	_
3	of	of	ADP	IN	_	_	_	_	_
4	evidence	evidence	NOUN	NN	Number=Sing	_	_	_	_
5	are	be	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
6	compatible	compatible	ADJ	JJ	Degree=Pos	_	_	_	_
7	with	with	ADP	IN	_	_	_	_	_
8	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
9	hypothesis	hypothesis	NOUN	NN	Number=Sing	_	_	_	_
10	that	that	PRON	WDT	PronType=Rel	_	_	_	_
11	Epstein	Epstein	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
12	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
13	Barr	Barr	PROPN	NNP	Number=Sing	_	_	_	_
14	virus	virus	NOUN	NN	Number=Sing	_	_	_	_
15	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
16	EBV	EBV	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
17	)	)	PUNCT	-RRB-	_	_	_	_	_
18	nuclear	nuclear	ADJ	JJ	Degree=Pos	_	_	_	_
19	antigen	antigen	NOUN	NN	Number=Sing	_	_	_	_
20	2	2	NUM	CD	NumType=Card	_	_	_	_
21	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
22	EBNA	EBNa	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
23	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
24	2	2	X	LS	_	_	_	_	SpaceAfter=No
25	)	)	PUNCT	-RRB-	_	_	_	_	_
26	or	or	CCONJ	CC	_	_	_	_	_
27	leader	leader	NOUN	NN	Number=Sing	_	_	_	_
28	protein	protein	NOUN	NN	Number=Sing	_	_	_	_
29	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
30	EBNA	EBNA	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
31	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
32	LP	LP	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
33	)	)	PUNCT	-RRB-	_	_	_	_	_
34	affects	affect	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
35	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
36	of	of	ADP	IN	_	_	_	_	_
37	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
38	EBV	EBV	PROPN	NNP	Number=Sing	_	_	_	_
39	latent	latent	ADJ	JJ	Degree=Pos	_	_	_	_
40	infection	infection	NOUN	NN	Number=Sing	_	_	_	_
41	membrane	membrane	NOUN	NN	Number=Sing	_	_	_	_
42	protein	protein	NOUN	NN	Number=Sing	_	_	_	_
43	LMP1	LMP1	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
44	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3314
# text = We now demonstrate the following.
1	We	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
2	now	now	ADV	RB	_	_	_	_	_
3	demonstrate	demonstrate	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
4	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
5	following	follow	VERB	VBG	VerbForm=Ger	_	_	_	SpaceAfter=No
6	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3315
# text = (i) Acute transfection and expression of EBNA-2 under control of simian virus 40 or Moloney murine leukemia virus promoters resulted in increased LMP1 expression in P3HR-1-infected Burkitt's lymphoma cells and the P3HR-1 or Daudi cell line.
1	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
2	i	i	X	LS	_	_	_	_	SpaceAfter=No
3	)	)	PUNCT	-RRB-	_	_	_	_	_
4	Acute	Acute	ADJ	JJ	Degree=Pos	_	_	_	_
5	transfection	transfection	NOUN	NN	Number=Sing	_	_	_	_
6	and	and	CCONJ	CC	_	_	_	_	_
7	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
8	of	of	ADP	IN	_	_	_	_	_
9	EBNA	EBNA	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
10	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
11	2	2	NUM	CD	NumType=Card	_	_	_	_
12	under	under	ADP	IN	_	_	_	_	_
13	control	control	NOUN	NN	Number=Sing	_	_	_	_
14	of	of	ADP	IN	_	_	_	_	_
15	simian	simian	ADJ	JJ	Degree=Pos	_	_	_	_
16	virus	virus	NOUN	NN	Number=Sing	_	_	_	_
17	40	40	NUM	CD	NumType=Card	_	_	_	_
18	or	or	CCONJ	CC	_	_	_	_	_
19	Moloney	Moloney	NOUN	NN	Number=Sing	_	_	_	_
20	murine	murine	NOUN	NN	Number=Sing	_	_	_	_
21	leukemia	leukemia	NOUN	NN	Number=Sing	_	_	_	_
22	virus	virus	NOUN	NN	Number=Sing	_	_	_	_
23	promoters	promoter	NOUN	NNS	Number=Plur	_	_	_	_
24	resulted	result	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
25	in	in	ADP	IN	_	_	_	_	_
26	increased	increase	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
27	LMP1	Lmp1	NUM	CD	NumType=Card	_	_	_	_
28	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
29	in	in	ADP	IN	_	_	_	_	_
30	P3HR	P3HR	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
31	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
32	1	1	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
33	-infected	-infect	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
34	Burkitt	Burkitt	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
35	's	's	PART	POS	_	_	_	_	_
36	lymphoma	lymphoma	NOUN	NN	Number=Sing	_	_	_	_
37	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
38	and	and	CCONJ	CC	_	_	_	_	_
39	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
40	P3HR	P3hr	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
41	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
42	1	1	NUM	CD	NumType=Card	_	_	_	_
43	or	or	CCONJ	CC	_	_	_	_	_
44	Daudi	Daudi	PROPN	NNP	Number=Sing	_	_	_	_
45	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
46	line	line	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
47	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3316
# text = (ii) Transfection and expression of EBNA-LP alone had no effect on LMP1 expression and did not act synergistically with EBNA-2 to affect LMP1 expression.
1	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
2	ii	ii	X	LS	_	_	_	_	SpaceAfter=No
3	)	)	PUNCT	-RRB-	_	_	_	_	_
4	Transfection	Transfection	NOUN	NN	Number=Sing	_	_	_	_
5	and	and	CCONJ	CC	_	_	_	_	_
6	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
7	of	of	ADP	IN	_	_	_	_	_
8	EBNA	EBNA	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
9	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
10	LP	LP	PROPN	NNP	Number=Sing	_	_	_	_
11	alone	alone	ADV	RB	_	_	_	_	_
12	had	have	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
13	no	no	DET	DT	_	_	_	_	_
14	effect	effect	NOUN	NN	Number=Sing	_	_	_	_
15	on	on	ADP	IN	_	_	_	_	_
16	LMP1	LMP1	NUM	CD	NumType=Card	_	_	_	_
17	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
18	and	and	CCONJ	CC	_	_	_	_	_
19	did	do	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
20	not	not	PART	RB	_	_	_	_	_
21	act	act	VERB	VB	VerbForm=Inf	_	_	_	_
22	synergistically	synergistically	ADV	RB	_	_	_	_	_
23	with	with	ADP	IN	_	_	_	_	_
24	EBNA	EBNA	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
25	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
26	2	2	NUM	CD	NumType=Card	_	_	_	_
27	to	to	PART	TO	_	_	_	_	_
28	affect	affect	VERB	VB	VerbForm=Inf	_	_	_	_
29	LMP1	LMP1	NUM	CD	NumType=Card	_	_	_	_
30	expression	expression	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
31	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3317
# text = (iii) LMP1 expression in Daudi and P3HR-1-infected cells was controlled at the mRNA level, and EBNA-2 expression in Daudi cells increased LMP1 mRNA.
1	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
2	iii	iii	X	LS	_	_	_	_	SpaceAfter=No
3	)	)	PUNCT	-RRB-	_	_	_	_	_
4	LMP1	Lmp1	NUM	CD	NumType=Card	_	_	_	_
5	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
6	in	in	ADP	IN	_	_	_	_	_
7	Daudi	Daudi	PROPN	NNP	Number=Sing	_	_	_	_
8	and	and	CCONJ	CC	_	_	_	_	_
9	P3HR	P3hr	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
10	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
11	1	1	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
12	-infected	-infected	ADJ	JJ	Degree=Pos	_	_	_	_
13	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
14	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
15	controlled	controll	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
16	at	at	ADP	IN	_	_	_	_	_
17	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
18	mRNA	mRNA	PROPN	NNP	Number=Sing	_	_	_	_
19	level	level	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
20	,	,	PUNCT	,	_	_	_	_	_
21	and	and	CCONJ	CC	_	_	_	_	_
22	EBNA	EBNA	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
23	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
24	2	2	NUM	CD	NumType=Card	_	_	_	_
25	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
26	in	in	ADP	IN	_	_	_	_	_
27	Daudi	Daudi	PROPN	NNP	Number=Sing	_	_	_	_
28	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
29	increased	increase	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
30	LMP1	LMP1	PROPN	NNP	Number=Sing	_	_	_	_
31	mRNA.	mRNA.	PROPN	NNP	Number=Sing	_	_	_	_

# sent_id = 3318
# text = (iv) No other EBV genes were required for EBNA-2 transactivation of LMP1 since cotransfection of recombinant EBNA-2 expression vectors and genomic LMP1 DNA fragments enhanced LMP1 expression in the EBV-negative B-lymphoma cell lines BJAB, Louckes, and BL30.
1	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
2	i	i	PRON	PRP	Case=Nom|Number=Sing|Person=1|PronType=Prs	_	_	_	SpaceAfter=No
3	v	have	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
4	)	)	PUNCT	-RRB-	_	_	_	_	_
5	No	no	DET	DT	_	_	_	_	_
6	other	other	ADJ	JJ	Degree=Pos	_	_	_	_
7	EBV	Ebv	PROPN	NNP	Number=Sing	_	_	_	_
8	genes	gene	NOUN	NNS	Number=Plur	_	_	_	_
9	were	be	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
10	required	require	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
11	for	for	ADP	IN	_	_	_	_	_
12	EBNA	EBNA	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
13	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
14	2	2	NUM	CD	NumType=Card	_	_	_	_
15	transactivation	transactivation	NOUN	NN	Number=Sing	_	_	_	_
16	of	of	ADP	IN	_	_	_	_	_
17	LMP1	LMP1	NUM	CD	NumType=Card	_	_	_	_
18	since	since	ADP	IN	_	_	_	_	_
19	cotransfection	cotransfection	NOUN	NN	Number=Sing	_	_	_	_
20	of	of	ADP	IN	_	_	_	_	_
21	recombinant	recombinant	ADJ	JJ	Degree=Pos	_	_	_	_
22	EBNA	EBNA	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
23	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
24	2	2	NUM	CD	NumType=Card	_	_	_	_
25	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
26	vectors	vector	NOUN	NNS	Number=Plur	_	_	_	_
27	and	and	CCONJ	CC	_	_	_	_	_
28	genomic	genomic	ADJ	JJ	Degree=Pos	_	_	_	_
29	LMP1	LMP1	NUM	CD	NumType=Card	_	_	_	_
30	DNA	dna	NOUN	NN	Number=Sing	_	_	_	_
31	fragments	fragment	NOUN	NNS	Number=Plur	_	_	_	_
32	enhanced	enhance	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
33	LMP1	Lmp1	NUM	CD	NumType=Card	_	_	_	_
34	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
35	in	in	ADP	IN	_	_	_	_	_
36	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
37	EBV	EBV	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
38	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
39	negative	negative	ADJ	JJ	Degree=Pos	_	_	_	_
40	B	b	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
41	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
42	lymphoma	lymphoma	NOUN	NN	Number=Sing	_	_	_	_
43	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
44	lines	line	NOUN	NNS	Number=Plur	_	_	_	_
45	BJAB	BJAB	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
46	,	,	PUNCT	,	_	_	_	_	_
47	Louckes	Louckes	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
48	,	,	PUNCT	,	_	_	_	_	_
49	and	and	CCONJ	CC	_	_	_	_	_
50	BL30	BL30	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
51	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3319
# text = (v) An EBNA-2-responsive element was found within the -512 to +40 LMP1 DNA since this DNA linked to a chloramphenicol acetyltransferase reporter gene was transactivated by cotransfection with an EBNA-2 expression vector.
1	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
2	v	v	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
3	)	)	PUNCT	-RRB-	_	_	_	_	_
4	An	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
5	EBNA	EBNA	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
6	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
7	2	2	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
8	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
9	responsive	responsive	ADJ	JJ	Degree=Pos	_	_	_	_
10	element	element	NOUN	NN	Number=Sing	_	_	_	_
11	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
12	found	find	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
13	within	within	ADP	IN	_	_	_	_	_
14	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
15	-	-	SYM	SYM	_	_	_	_	SpaceAfter=No
16	512	512	NUM	CD	NumType=Card	_	_	_	_
17	to	to	ADP	IN	_	_	_	_	_
18	+40	+40	NUM	CD	NumType=Card	_	_	_	_
19	LMP1	LMP1	NUM	CD	NumType=Card	_	_	_	_
20	DNA	dna	NOUN	NN	Number=Sing	_	_	_	_
21	since	since	ADP	IN	_	_	_	_	_
22	this	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
23	DNA	dna	NOUN	NN	Number=Sing	_	_	_	_
24	linked	link	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
25	to	to	ADP	IN	_	_	_	_	_
26	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
27	chloramphenicol	chloramphenicol	NOUN	NN	Number=Sing	_	_	_	_
28	acetyltransferase	acetyltransferase	NOUN	NN	Number=Sing	_	_	_	_
29	reporter	reporter	NOUN	NN	Number=Sing	_	_	_	_
30	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
31	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
32	transactivated	transactivate	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
33	by	by	ADP	IN	_	_	_	_	_
34	cotransfection	cotransfection	NOUN	NN	Number=Sing	_	_	_	_
35	with	with	ADP	IN	_	_	_	_	_
36	an	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
37	EBNA	EBNA	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
38	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
39	2	2	NUM	CD	NumType=Card	_	_	_	_
40	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
41	vector	vector	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
42	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3320
# text = (vi) The EBV type 2 EBNA-2 transactivated LMP1 as well as the EBV type 1 EBNA-2.
1	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
2	vi	vi	X	LS	_	_	_	_	SpaceAfter=No
3	)	)	PUNCT	-RRB-	_	_	_	_	_
4	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
5	EBV	EBV	PROPN	NNP	Number=Sing	_	_	_	_
6	type	type	NOUN	NN	Number=Sing	_	_	_	_
7	2	2	NUM	CD	NumType=Card	_	_	_	_
8	EBNA	EBNA	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
9	-	-	SYM	SYM	_	_	_	_	SpaceAfter=No
10	2	2	NUM	CD	NumType=Card	_	_	_	_
11	transactivated	transactivate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
12	LMP1	Lmp1	PROPN	NNP	Number=Sing	_	_	_	_
13	as	as	ADV	RB	_	_	_	_	_
14	well	well	ADV	RB	Degree=Pos	_	_	_	_
15	as	as	ADP	IN	_	_	_	_	_
16	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
17	EBV	EBV	PROPN	NNP	Number=Sing	_	_	_	_
18	type	type	NOUN	NN	Number=Sing	_	_	_	_
19	1	1	NUM	CD	NumType=Card	_	_	_	_
20	EBNA	EBNA	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
21	-	-	SYM	SYM	_	_	_	_	SpaceAfter=No
22	2	2	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
23	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3321
# text = (vii) Two deletions within the EBNA-2 gene which rendered EBV transformation incompetent did not transactivate LMP1, whereas a transformation-competent EBNA-2 deletion mutant did transactivate LMP1.
1	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
2	vii	vii	X	LS	_	_	_	_	SpaceAfter=No
3	)	)	PUNCT	-RRB-	_	_	_	_	_
4	Two	two	NUM	CD	NumType=Card	_	_	_	_
5	deletions	deletion	NOUN	NNS	Number=Plur	_	_	_	_
6	within	within	ADP	IN	_	_	_	_	_
7	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
8	EBNA	EBNA	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
9	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
10	2	2	NUM	CD	NumType=Card	_	_	_	_
11	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
12	which	which	PRON	WDT	PronType=Rel	_	_	_	_
13	rendered	render	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
14	EBV	EBV	PROPN	NNP	Number=Sing	_	_	_	_
15	transformation	transformation	NOUN	NN	Number=Sing	_	_	_	_
16	incompetent	incompetent	NOUN	NN	Number=Sing	_	_	_	_
17	did	do	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
18	not	not	PART	RB	_	_	_	_	_
19	transactivate	transactivate	VERB	VB	VerbForm=Inf	_	_	_	_
20	LMP1	LMP1	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
21	,	,	PUNCT	,	_	_	_	_	_
22	whereas	whereas	SCONJ	IN	_	_	_	_	_
23	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
24	transformation	transformation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
25	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
26	competent	competent	NOUN	NN	Number=Sing	_	_	_	_
27	EBNA	EBNa	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
28	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
29	2	2	NUM	CD	NumType=Card	_	_	_	_
30	deletion	deletion	NOUN	NN	Number=Sing	_	_	_	_
31	mutant	mutant	NOUN	NN	Number=Sing	_	_	_	_
32	did	do	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
33	transactivate	transactivate	VERB	VB	VerbForm=Inf	_	_	_	_
34	LMP1	LMP1	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
35	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3322
# text = LMP1 is a potent effector of B-lymphocyte activation and can act synergistically with EBNA-2 to induce cellular CD23 gene expression.
1	LMP1	Lmp1	PROPN	NNP	Number=Sing	_	_	_	_
2	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
3	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
4	potent	potent	NOUN	NN	Number=Sing	_	_	_	_
5	effector	effector	NOUN	NN	Number=Sing	_	_	_	_
6	of	of	ADP	IN	_	_	_	_	_
7	B	B	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
8	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
9	lymphocyte	lymphocyte	NOUN	NN	Number=Sing	_	_	_	_
10	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
11	and	and	CCONJ	CC	_	_	_	_	_
12	can	can	AUX	MD	VerbForm=Fin	_	_	_	_
13	act	act	VERB	VB	VerbForm=Inf	_	_	_	_
14	synergistically	synergistically	ADV	RB	_	_	_	_	_
15	with	with	ADP	IN	_	_	_	_	_
16	EBNA	EBNA	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
17	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
18	2	2	NUM	CD	NumType=Card	_	_	_	_
19	to	to	PART	TO	_	_	_	_	_
20	induce	induce	VERB	VB	VerbForm=Inf	_	_	_	_
21	cellular	celular	ADJ	JJ	Degree=Pos	_	_	_	_
22	CD23	CD23	NOUN	NN	Number=Sing	_	_	_	_
23	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
24	expression	expression	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
25	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3323
# text = Thus, EBNA-2 transactivation of LMP1 amplifies the biological impact of EBNA-2 and underscores its central role in EBV-induced growth transformation.
1	Thus	thus	ADV	RB	_	_	_	_	SpaceAfter=No
2	,	,	PUNCT	,	_	_	_	_	_
3	EBNA	EBNA	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
4	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
5	2	2	NUM	CD	NumType=Card	_	_	_	_
6	transactivation	transactivation	NOUN	NN	Number=Sing	_	_	_	_
7	of	of	ADP	IN	_	_	_	_	_
8	LMP1	LMP1	PROPN	NNP	Number=Sing	_	_	_	_
9	amplifies	amplify	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
10	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
11	biological	biological	ADJ	JJ	Degree=Pos	_	_	_	_
12	impact	impact	NOUN	NN	Number=Sing	_	_	_	_
13	of	of	ADP	IN	_	_	_	_	_
14	EBNA	EBNA	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
15	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
16	2	2	NUM	CD	NumType=Card	_	_	_	_
17	and	and	CCONJ	CC	_	_	_	_	_
18	underscores	underscore	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
19	its	its	PRON	PRP$	Gender=Neut|Number=Sing|Person=3|Poss=Yes|PronType=Prs	_	_	_	_
20	central	central	ADJ	JJ	Degree=Pos	_	_	_	_
21	role	role	NOUN	NN	Number=Sing	_	_	_	_
22	in	in	ADP	IN	_	_	_	_	_
23	EBV	EBV	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
24	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
25	induced	induce	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
26	growth	growth	NOUN	NN	Number=Sing	_	_	_	_
27	transformation	transformation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
28	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 3324
# text = Document 003003446 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	003003446	003003446	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 3325
# text = Microtubules mediate cellular 25-hydroxyvitamin D3 trafficking and the genomic response to 1,25-dihydroxyvitamin D3 in normal human monocytes.
1	Microtubules	Microtubule	NOUN	NNS	Number=Plur	_	_	_	_
2	mediate	mediate	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
3	cellular	celular	ADJ	JJ	Degree=Pos	_	_	_	_
4	25	25	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
5	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
6	hydroxyvitamin	hydroxyvitamin	NOUN	NN	Number=Sing	_	_	_	_
7	D3	D3	NOUN	NN	Number=Sing	_	_	_	_
8	trafficking	trafficking	NOUN	NN	Number=Sing	_	_	_	_
9	and	and	CCONJ	CC	_	_	_	_	_
10	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
11	genomic	genomic	ADJ	JJ	Degree=Pos	_	_	_	_
12	response	response	NOUN	NN	Number=Sing	_	_	_	_
13	to	to	ADP	IN	_	_	_	_	_
14	1,25	1,25	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
15	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
16	dihydroxyvitamin	dihydroxyvitamin	NOUN	NN	Number=Sing	_	_	_	_
17	D3	D3	NOUN	NN	Number=Sing	_	_	_	_
18	in	in	ADP	IN	_	_	_	_	_
19	normal	normal	ADJ	JJ	Degree=Pos	_	_	_	_
20	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
21	monocytes	monocyte	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
22	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 3326
# text = The genomic actions of 1,25-dihydroxyvitamin D3 (1,25(OH)2D3) are mediated by the intracellular vitamin D receptor (VDR).
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	genomic	genomic	ADJ	JJ	Degree=Pos	_	_	_	_
3	actions	action	NOUN	NNS	Number=Plur	_	_	_	_
4	of	of	ADP	IN	_	_	_	_	_
5	1,25	1,25	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
6	-	-	PUNCT	:	_	_	_	_	SpaceAfter=No
7	dihydroxyvitamin	dihydroxyvitamin	NOUN	NN	Number=Sing	_	_	_	_
8	D3	D3	NOUN	NN	Number=Sing	_	_	_	_
9	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
10	1,25	1,25	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
11	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
12	OH	Oh	INTJ	UH	_	_	_	_	SpaceAfter=No
13	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
14	2D3	2D3	X	LS	_	_	_	_	SpaceAfter=No
15	)	)	PUNCT	-RRB-	_	_	_	_	_
16	are	be	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
17	mediated	mediate	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
18	by	by	ADP	IN	_	_	_	_	_
19	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
20	intracellular	intracellular	ADJ	JJ	Degree=Pos	_	_	_	_
21	vitamin	vitamin	NOUN	NN	Number=Sing	_	_	_	_
22	D	d	NOUN	NN	Number=Sing	_	_	_	_
23	receptor	receptor	NOUN	NN	Number=Sing	_	_	_	_
24	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
25	VDR	VDR	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
26	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
27	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3327
# text = Although immunocytochemistry has shown that disruption of microtubular assembly prevents nuclear access of the sterol-VDR complex, the role of microtubules in the response to 1,25(OH)2D3 has not been studied in viable cells.
1	Although	although	SCONJ	IN	_	_	_	_	_
2	immunocytochemistry	immunocytochemistry	PROPN	NNP	Number=Sing	_	_	_	_
3	has	have	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
4	shown	show	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
5	that	that	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
6	disruption	disruption	NOUN	NN	Number=Sing	_	_	_	_
7	of	of	ADP	IN	_	_	_	_	_
8	microtubular	microtubular	ADJ	JJ	Degree=Pos	_	_	_	_
9	assembly	assembly	NOUN	NN	Number=Sing	_	_	_	_
10	prevents	prevent	NOUN	NNS	Number=Plur	_	_	_	_
11	nuclear	nuclear	ADJ	JJ	Degree=Pos	_	_	_	_
12	access	access	NOUN	NN	Number=Sing	_	_	_	_
13	of	of	ADP	IN	_	_	_	_	_
14	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
15	sterol	sterol	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
16	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
17	VDR	Vdr	NOUN	NN	Number=Sing	_	_	_	_
18	complex	complex	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
19	,	,	PUNCT	,	_	_	_	_	_
20	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
21	role	role	NOUN	NN	Number=Sing	_	_	_	_
22	of	of	ADP	IN	_	_	_	_	_
23	microtubules	microtubule	NOUN	NNS	Number=Plur	_	_	_	_
24	in	in	ADP	IN	_	_	_	_	_
25	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
26	response	response	NOUN	NN	Number=Sing	_	_	_	_
27	to	to	ADP	IN	_	_	_	_	_
28	1,25	1,25	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
29	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
30	OH	Oh	INTJ	UH	_	_	_	_	SpaceAfter=No
31	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
32	2D3	2D3	NOUN	NN	Number=Sing	_	_	_	_
33	has	have	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
34	not	not	PART	RB	_	_	_	_	_
35	been	be	AUX	VBN	Tense=Past|VerbForm=Part	_	_	_	_
36	studied	study	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
37	in	in	ADP	IN	_	_	_	_	_
38	viable	viable	ADJ	JJ	Degree=Pos	_	_	_	_
39	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
40	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3328
# text = Our studies examined this interaction in normal human monocytes.
1	Our	we	PRON	PRP$	Number=Plur|Person=1|Poss=Yes|PronType=Prs	_	_	_	_
2	studies	study	NOUN	NNS	Number=Plur	_	_	_	_
3	examined	examin	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
4	this	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
5	interaction	interaction	NOUN	NN	Number=Sing	_	_	_	_
6	in	in	ADP	IN	_	_	_	_	_
7	normal	normal	ADJ	JJ	Degree=Pos	_	_	_	_
8	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
9	monocytes	monocyte	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
10	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3329
# text = Monocytes convert 25(OH)D3 to 1,25(OH)2D3 and to 24-hydroxylated metabolites more polar than 1,25(OH)2D3.
1	Monocytes	Monocytes	PROPN	NNP	Number=Sing	_	_	_	_
2	convert	convert	NOUN	NN	Number=Sing	_	_	_	_
3	25	25	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
4	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
5	OH	Oh	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
6	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
7	D3	D3	NUM	CD	NumType=Card	_	_	_	_
8	to	to	ADP	IN	_	_	_	_	_
9	1,25	1,25	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
10	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
11	OH	Oh	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
12	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
13	2D3	2D3	NUM	CD	NumType=Card	_	_	_	_
14	and	and	CCONJ	CC	_	_	_	_	_
15	to	to	ADP	IN	_	_	_	_	_
16	24	24	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
17	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
18	hydroxylated	hydroxylate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
19	metabolites	metabolite	NOUN	NNS	Number=Plur	_	_	_	_
20	more	more	ADV	RBR	_	_	_	_	_
21	polar	polar	ADJ	JJ	Degree=Pos	_	_	_	_
22	than	than	ADP	IN	_	_	_	_	_
23	1,25	1,25	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
24	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
25	OH	Oh	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
26	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
27	2D3	2D3	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
28	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3330
# text = Microtubule disruption totally abolished the ability of exogenous 1,25(OH)2D3 to suppress its own synthesis and to induce 24-hydroxylase mRNA and activity, without affecting either total 1,25(OH)2D3 uptake or maximal 1,25(OH)2D3-VDR binding.
1	Microtubule	Microtubule	NOUN	NN	Number=Sing	_	_	_	_
2	disruption	disruption	NOUN	NN	Number=Sing	_	_	_	_
3	totally	totally	ADV	RB	_	_	_	_	_
4	abolished	abolish	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
5	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
6	ability	ability	NOUN	NN	Number=Sing	_	_	_	_
7	of	of	ADP	IN	_	_	_	_	_
8	exogenous	exogenous	ADJ	JJ	Degree=Pos	_	_	_	_
9	1,25	1,25	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
10	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
11	OH	oh	INTJ	UH	_	_	_	_	SpaceAfter=No
12	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
13	2D3	2D3	NOUN	NN	Number=Sing	_	_	_	_
14	to	to	PART	TO	_	_	_	_	_
15	suppress	suppress	VERB	VB	VerbForm=Inf	_	_	_	_
16	its	its	PRON	PRP$	Gender=Neut|Number=Sing|Person=3|Poss=Yes|PronType=Prs	_	_	_	_
17	own	own	ADJ	JJ	Degree=Pos	_	_	_	_
18	synthesis	synthesis	NOUN	NN	Number=Sing	_	_	_	_
19	and	and	CCONJ	CC	_	_	_	_	_
20	to	to	PART	TO	_	_	_	_	_
21	induce	induce	VERB	VB	VerbForm=Inf	_	_	_	_
22	24	24	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
23	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
24	hydroxylase	hydroxylase	NOUN	NN	Number=Sing	_	_	_	_
25	mRNA	mRNa	NOUN	NN	Number=Sing	_	_	_	_
26	and	and	CCONJ	CC	_	_	_	_	_
27	activity	activity	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
28	,	,	PUNCT	,	_	_	_	_	_
29	without	without	SCONJ	IN	_	_	_	_	_
30	affecting	affect	VERB	VBG	VerbForm=Ger	_	_	_	_
31	either	either	DET	DT	_	_	_	_	_
32	total	total	ADJ	JJ	Degree=Pos	_	_	_	_
33	1,25	1,25	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
34	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
35	OH	oh	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
36	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
37	2D3	2D3	NUM	CD	NumType=Card	_	_	_	_
38	uptake	uptake	NOUN	NN	Number=Sing	_	_	_	_
39	or	or	CCONJ	CC	_	_	_	_	_
40	maximal	maximal	ADJ	JJ	Degree=Pos	_	_	_	_
41	1,25	1,25	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
42	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
43	OH	Oh	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
44	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
45	2D3	2D3	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
46	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
47	VDR	Vdr	NOUN	NN	Number=Sing	_	_	_	_
48	binding	binding	VERB	VBG	VerbForm=Ger	_	_	_	SpaceAfter=No
49	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3331
# text = Thus, intact microtubules are essential for 1,25(OH)2D3-dependent modulation of gene transcription.
1	Thus	thus	ADV	RB	_	_	_	_	SpaceAfter=No
2	,	,	PUNCT	,	_	_	_	_	_
3	intact	intact	ADJ	JJ	Degree=Pos	_	_	_	_
4	microtubules	microtubule	NOUN	NNS	Number=Plur	_	_	_	_
5	are	be	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
6	essential	essential	ADJ	JJ	Degree=Pos	_	_	_	_
7	for	for	ADP	IN	_	_	_	_	_
8	1,25	1,25	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
9	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
10	OH	Oh	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
11	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
12	2D3	2D3	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
13	-dependent	-dependent	ADJ	JJ	Degree=Pos	_	_	_	_
14	modulation	modulation	NOUN	NN	Number=Sing	_	_	_	_
15	of	of	ADP	IN	_	_	_	_	_
16	gene	gene	ADJ	JJ	Degree=Pos	_	_	_	_
17	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
18	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3332
# text = Interestingly, microtubule disruption also decreased monocyte 1,25(OH)2D3 synthesis, not by decreasing the Vmax of monocyte mitochondrial 1 alpha-hydroxylase but through an increase in the Km for 25(OH)2D3.
1	Interestingly	Interestingly	ADV	RB	_	_	_	_	SpaceAfter=No
2	,	,	PUNCT	,	_	_	_	_	_
3	microtubule	microtubule	ADJ	JJ	Degree=Pos	_	_	_	_
4	disruption	disruption	NOUN	NN	Number=Sing	_	_	_	_
5	also	also	ADV	RB	_	_	_	_	_
6	decreased	decrease	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
7	monocyte	monocyte	NOUN	NN	Number=Sing	_	_	_	_
8	1,25	1,25	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
9	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
10	OH	Oh	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
11	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
12	2D3	2D3	NUM	CD	NumType=Card	_	_	_	_
13	synthesis	synthesis	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
14	,	,	PUNCT	,	_	_	_	_	_
15	not	not	ADV	RB	_	_	_	_	_
16	by	by	SCONJ	IN	_	_	_	_	_
17	decreasing	decrease	VERB	VBG	VerbForm=Ger	_	_	_	_
18	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
19	Vmax	Vmax	NOUN	NN	Number=Sing	_	_	_	_
20	of	of	ADP	IN	_	_	_	_	_
21	monocyte	monocyte	NOUN	NN	Number=Sing	_	_	_	_
22	mitochondrial	mitochondrial	NOUN	NN	Number=Sing	_	_	_	_
23	1	1	NUM	CD	NumType=Card	_	_	_	_
24	alpha	alpha	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
25	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
26	hydroxylase	hydroxylase	NOUN	NN	Number=Sing	_	_	_	_
27	but	but	CCONJ	CC	_	_	_	_	_
28	through	through	ADP	IN	_	_	_	_	_
29	an	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
30	increase	increase	NOUN	NN	Number=Sing	_	_	_	_
31	in	in	ADP	IN	_	_	_	_	_
32	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
33	Km	Km	PROPN	NNP	Number=Sing	_	_	_	_
34	for	for	ADP	IN	_	_	_	_	_
35	25	25	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
36	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
37	OH	oh	INTJ	UH	_	_	_	_	SpaceAfter=No
38	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
39	2D3	2D3	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
40	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3333
# text = We examined 25(OH)D3 transport.
1	We	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
2	examined	examin	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
3	25	25	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
4	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
5	OH	oh	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
6	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
7	D3	D3	NUM	CD	NumType=Card	_	_	_	_
8	transport	transport	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
9	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3334
# text = Microtubule disruption did not affect total cellular 25(OH)D3 uptake but reduced its intracellular trafficking to the mitochondria.
1	Microtubule	Microtubule	NOUN	NN	Number=Sing	_	_	_	_
2	disruption	disruption	NOUN	NN	Number=Sing	_	_	_	_
3	did	do	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
4	not	not	PART	RB	_	_	_	_	_
5	affect	affect	VERB	VB	VerbForm=Inf	_	_	_	_
6	total	total	ADJ	JJ	Degree=Pos	_	_	_	_
7	cellular	celular	NOUN	NN	Number=Sing	_	_	_	_
8	25	25	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
9	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
10	OH	oh	INTJ	UH	_	_	_	_	SpaceAfter=No
11	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
12	D3	D3	NOUN	NN	Number=Sing	_	_	_	_
13	uptake	uptake	NOUN	NN	Number=Sing	_	_	_	_
14	but	but	CCONJ	CC	_	_	_	_	_
15	reduced	reduce	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
16	its	its	PRON	PRP$	Gender=Neut|Number=Sing|Person=3|Poss=Yes|PronType=Prs	_	_	_	_
17	intracellular	intracelular	ADJ	JJ	Degree=Pos	_	_	_	_
18	trafficking	traffick	NOUN	NN	Number=Sing	_	_	_	_
19	to	to	ADP	IN	_	_	_	_	_
20	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
21	mitochondria	mitochondria	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
22	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3335
# text = Thus, microtubules participate in intracellular 25(OH)D3 transport, and their integrity determines normal 1,25(OH)2D3 synthesis.
1	Thus	thus	ADV	RB	_	_	_	_	SpaceAfter=No
2	,	,	PUNCT	,	_	_	_	_	_
3	microtubules	microtubule	NOUN	NNS	Number=Plur	_	_	_	_
4	participate	participate	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
5	in	in	ADP	IN	_	_	_	_	_
6	intracellular	intracellular	ADJ	JJ	Degree=Pos	_	_	_	_
7	25	25	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
8	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
9	OH	oh	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
10	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
11	D3	D3	NUM	CD	NumType=Card	_	_	_	_
12	transport	transport	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
13	,	,	PUNCT	,	_	_	_	_	_
14	and	and	CCONJ	CC	_	_	_	_	_
15	their	they	PRON	PRP$	Number=Plur|Person=3|Poss=Yes|PronType=Prs	_	_	_	_
16	integrity	integrity	NOUN	NN	Number=Sing	_	_	_	_
17	determines	determine	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
18	normal	normal	ADJ	JJ	Degree=Pos	_	_	_	_
19	1,25	1,25	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
20	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
21	OH	oh	INTJ	UH	_	_	_	_	SpaceAfter=No
22	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
23	2D3	2D3	NUM	CD	NumType=Card	_	_	_	_
24	synthesis	synthesis	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
25	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 3336
# text = Document 003003447 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	003003447	003003447	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 3337
# text = Regulation of interferon-gamma gene expression.
1	Regulation	regulation	NOUN	NN	Number=Sing	_	_	_	_
2	of	of	ADP	IN	_	_	_	_	_
3	interferon	interferon	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
4	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
5	gamma	gamma	NOUN	NN	Number=Sing	_	_	_	_
6	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
7	expression	expression	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
8	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 3338
# text = Interferon-gamma ( IFN-gamma ), also known as type II interferon, is an important immunoregulatory gene that has multiple effects on the development, maturation, and function of the immune system.
1	Interferon	Interferon	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
2	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
3	gamma	gamma	NOUN	NN	Number=Sing	_	_	_	_
4	(	(	PUNCT	-LRB-	_	_	_	_	_
5	IFN	Ifn	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
6	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
7	gamma	gamma	NOUN	NN	Number=Sing	_	_	_	_
8	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
9	,	,	PUNCT	,	_	_	_	_	_
10	also	also	ADV	RB	_	_	_	_	_
11	known	know	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
12	as	as	ADP	IN	_	_	_	_	_
13	type	type	NOUN	NN	Number=Sing	_	_	_	_
14	II	ii	PROPN	NNP	Number=Sing	_	_	_	_
15	interferon	interferon	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
16	,	,	PUNCT	,	_	_	_	_	_
17	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
18	an	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
19	important	important	ADJ	JJ	Degree=Pos	_	_	_	_
20	immunoregulatory	immunoregulatory	ADJ	JJ	Degree=Pos	_	_	_	_
21	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
22	that	that	PRON	WDT	PronType=Rel	_	_	_	_
23	has	have	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
24	multiple	multiple	ADJ	JJ	Degree=Pos	_	_	_	_
25	effects	effect	NOUN	NNS	Number=Plur	_	_	_	_
26	on	on	ADP	IN	_	_	_	_	_
27	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
28	development	development	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
29	,	,	PUNCT	,	_	_	_	_	_
30	maturation	maturation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
31	,	,	PUNCT	,	_	_	_	_	_
32	and	and	CCONJ	CC	_	_	_	_	_
33	function	function	NOUN	NN	Number=Sing	_	_	_	_
34	of	of	ADP	IN	_	_	_	_	_
35	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
36	immune	immune	ADJ	JJ	Degree=Pos	_	_	_	_
37	system	system	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
38	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3339
# text = IFN-gamma mRNA and protein are expressed predominantly by T cells and large granular lymphocytes.
1	IFN-	IFN-	SYM	NFP	_	_	_	_	SpaceAfter=No
2	gamma	gamma	NOUN	NN	Number=Sing	_	_	_	_
3	mRNA	mRNa	NOUN	NN	Number=Sing	_	_	_	_
4	and	and	CCONJ	CC	_	_	_	_	_
5	protein	protein	NOUN	NN	Number=Sing	_	_	_	_
6	are	be	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
7	expressed	express	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
8	predominantly	predominantly	ADV	RB	_	_	_	_	_
9	by	by	ADP	IN	_	_	_	_	_
10	T	t	PROPN	NNP	Number=Sing	_	_	_	_
11	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
12	and	and	CCONJ	CC	_	_	_	_	_
13	large	large	ADJ	JJ	Degree=Pos	_	_	_	_
14	granular	granular	ADJ	JJ	Degree=Pos	_	_	_	_
15	lymphocytes	lymphocyte	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
16	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3340
# text = The IFN-gamma mRNA is induced/inhibited in these cell types by a wide variety of extracellular signals, thus implicating a number of diverse, yet convergent signal transduction pathways in its transcriptional control.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	IFN	Ifn	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
3	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
4	gamma	gamma	NOUN	NN	Number=Sing	_	_	_	_
5	mRNA	mRNa	NOUN	NN	Number=Sing	_	_	_	_
6	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
7	induced	induce	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	SpaceAfter=No
8	/	/	PUNCT	,	_	_	_	_	SpaceAfter=No
9	inhibited	inhibit	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
10	in	in	ADP	IN	_	_	_	_	_
11	these	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
12	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
13	types	type	NOUN	NNS	Number=Plur	_	_	_	_
14	by	by	ADP	IN	_	_	_	_	_
15	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
16	wide	wide	ADJ	JJ	Degree=Pos	_	_	_	_
17	variety	variety	NOUN	NN	Number=Sing	_	_	_	_
18	of	of	ADP	IN	_	_	_	_	_
19	extracellular	extracellular	ADJ	JJ	Degree=Pos	_	_	_	_
20	signals	signal	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
21	,	,	PUNCT	,	_	_	_	_	_
22	thus	thus	ADV	RB	_	_	_	_	_
23	implicating	implicate	VERB	VBG	VerbForm=Ger	_	_	_	_
24	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
25	number	number	NOUN	NN	Number=Sing	_	_	_	_
26	of	of	ADP	IN	_	_	_	_	_
27	diverse	diverse	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
28	,	,	PUNCT	,	_	_	_	_	_
29	yet	yet	CCONJ	CC	_	_	_	_	_
30	convergent	convergent	ADJ	JJ	Degree=Pos	_	_	_	_
31	signal	signal	NOUN	NN	Number=Sing	_	_	_	_
32	transduction	transduction	NOUN	NN	Number=Sing	_	_	_	_
33	pathways	pathway	NOUN	NNS	Number=Plur	_	_	_	_
34	in	in	ADP	IN	_	_	_	_	_
35	its	its	PRON	PRP$	Gender=Neut|Number=Sing|Person=3|Poss=Yes|PronType=Prs	_	_	_	_
36	transcriptional	transcriptional	ADJ	JJ	Degree=Pos	_	_	_	_
37	control	control	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
38	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3341
# text = In this review, I describe how DNA methylation and specific DNA binding proteins may regulate transcription of the IFN-gamma gene in response to extracellular signals.
1	In	in	ADP	IN	_	_	_	_	_
2	this	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
3	review	review	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
4	,	,	PUNCT	,	_	_	_	_	_
5	I	I	PRON	PRP	Case=Nom|Number=Sing|Person=1|PronType=Prs	_	_	_	_
6	describe	describe	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
7	how	how	ADV	WRB	PronType=Int	_	_	_	_
8	DNA	dna	NOUN	NN	Number=Sing	_	_	_	_
9	methylation	methylation	NOUN	NN	Number=Sing	_	_	_	_
10	and	and	CCONJ	CC	_	_	_	_	_
11	specific	specific	ADJ	JJ	Degree=Pos	_	_	_	_
12	DNA	dna	NOUN	NN	Number=Sing	_	_	_	_
13	binding	binding	VERB	VBG	VerbForm=Ger	_	_	_	_
14	proteins	protein	NOUN	NNS	Number=Plur	_	_	_	_
15	may	may	AUX	MD	VerbForm=Fin	_	_	_	_
16	regulate	regulate	VERB	VB	VerbForm=Inf	_	_	_	_
17	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
18	of	of	ADP	IN	_	_	_	_	_
19	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
20	IFN	Ifn	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
21	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
22	gamma	gamma	NOUN	NN	Number=Sing	_	_	_	_
23	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
24	in	in	ADP	IN	_	_	_	_	_
25	response	response	NOUN	NN	Number=Sing	_	_	_	_
26	to	to	ADP	IN	_	_	_	_	_
27	extracellular	extracellular	ADJ	JJ	Degree=Pos	_	_	_	_
28	signals	signal	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
29	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 3342
# text = Document 003003449 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	003003449	003003449	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 3343
# text = Signal transduction by DR3, a death domain-containing receptor related to TNFR-1 and CD95.
1	Signal	signal	ADJ	JJ	Degree=Pos	_	_	_	_
2	transduction	transduction	NOUN	NN	Number=Sing	_	_	_	_
3	by	by	ADP	IN	_	_	_	_	_
4	DR3	DR3	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
5	,	,	PUNCT	,	_	_	_	_	_
6	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
7	death	death	NOUN	NN	Number=Sing	_	_	_	_
8	domain	domain	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
9	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
10	containing	containing	VERB	VBG	VerbForm=Ger	_	_	_	_
11	receptor	receptor	NOUN	NN	Number=Sing	_	_	_	_
12	related	related	ADJ	JJ	Degree=Pos	_	_	_	_
13	to	to	ADP	IN	_	_	_	_	_
14	TNFR	TNFR	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
15	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
16	1	1	NUM	CD	NumType=Card	_	_	_	_
17	and	and	CCONJ	CC	_	_	_	_	_
18	CD95	CD95	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
19	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 3344
# text = Tumor necrosis factor receptor-1 (TNFR-1) and CD95 (also called Fas or APO-1) are cytokine receptors that engage the apoptosis pathway through a region of intracellular homology, designated the "death domain."
1	Tumor	tumor	ADP	IN	_	_	_	_	_
2	necrosis	necrosis	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
3	factor	factor	NOUN	NN	Number=Sing	_	_	_	_
4	receptor	receptor	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
5	-	-	PUNCT	:	_	_	_	_	SpaceAfter=No
6	1	1	NUM	CD	NumType=Card	_	_	_	_
7	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
8	TNFR	Tnfr	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
9	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
10	1	1	X	LS	_	_	_	_	SpaceAfter=No
11	)	)	PUNCT	-RRB-	_	_	_	_	_
12	and	and	CCONJ	CC	_	_	_	_	_
13	CD95	CD95	PROPN	NNP	Number=Sing	_	_	_	_
14	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
15	also	also	ADV	RB	_	_	_	_	_
16	called	call	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
17	Fas	Fas	NOUN	NNS	Number=Plur	_	_	_	_
18	or	or	CCONJ	CC	_	_	_	_	_
19	APO	APO	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
20	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
21	1	1	X	LS	_	_	_	_	SpaceAfter=No
22	)	)	PUNCT	-RRB-	_	_	_	_	_
23	are	be	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
24	cytokine	cytokine	ADJ	JJ	Degree=Pos	_	_	_	_
25	receptors	receptor	NOUN	NNS	Number=Plur	_	_	_	_
26	that	that	PRON	WDT	PronType=Rel	_	_	_	_
27	engage	engage	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
28	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
29	apoptosis	apoptosis	NOUN	NN	Number=Sing	_	_	_	_
30	pathway	pathway	NOUN	NN	Number=Sing	_	_	_	_
31	through	through	ADP	IN	_	_	_	_	_
32	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
33	region	region	NOUN	NN	Number=Sing	_	_	_	_
34	of	of	ADP	IN	_	_	_	_	_
35	intracellular	intracellular	ADJ	JJ	Degree=Pos	_	_	_	_
36	homology	homology	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
37	,	,	PUNCT	,	_	_	_	_	_
38	designated	designate	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
39	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
40	"	"	PUNCT	``	_	_	_	_	SpaceAfter=No
41	death	death	NOUN	NN	Number=Sing	_	_	_	_
42	domain	domain	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
43	.	.	PUNCT	.	_	_	_	_	SpaceAfter=No
44	"	"	PUNCT	''	_	_	_	_	_

# sent_id = 3345
# text = Another death domain-containing member of the TNFR family, death receptor 3 (DR3), was identified and was shown to induce both apoptosis and activation of nuclear factor kappaB.
1	Another	another	DET	DT	_	_	_	_	_
2	death	death	NOUN	NN	Number=Sing	_	_	_	_
3	domain	domain	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
4	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
5	containing	contain	VERB	VBG	VerbForm=Ger	_	_	_	_
6	member	member	NOUN	NN	Number=Sing	_	_	_	_
7	of	of	ADP	IN	_	_	_	_	_
8	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
9	TNFR	TNFR	PROPN	NNP	Number=Sing	_	_	_	_
10	family	family	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
11	,	,	PUNCT	,	_	_	_	_	_
12	death	death	NOUN	NN	Number=Sing	_	_	_	_
13	receptor	receptor	NOUN	NN	Number=Sing	_	_	_	_
14	3	3	NUM	CD	NumType=Card	_	_	_	_
15	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
16	DR3	DR3	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
17	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
18	,	,	PUNCT	,	_	_	_	_	_
19	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
20	identified	identify	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
21	and	and	CCONJ	CC	_	_	_	_	_
22	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
23	shown	show	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
24	to	to	PART	TO	_	_	_	_	_
25	induce	induce	VERB	VB	VerbForm=Inf	_	_	_	_
26	both	both	CCONJ	CC	_	_	_	_	_
27	apoptosis	apoptosis	NOUN	NN	Number=Sing	_	_	_	_
28	and	and	CCONJ	CC	_	_	_	_	_
29	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
30	of	of	ADP	IN	_	_	_	_	_
31	nuclear	nuclear	ADJ	JJ	Degree=Pos	_	_	_	_
32	factor	factor	NOUN	NN	Number=Sing	_	_	_	_
33	kappaB	kappab	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
34	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3346
# text = Expression of DR3 appears to be restricted to tissues enriched in lymphocytes.
1	Expression	expression	NOUN	NN	Number=Sing	_	_	_	_
2	of	of	ADP	IN	_	_	_	_	_
3	DR3	DR3	NOUN	NN	Number=Sing	_	_	_	_
4	appears	appear	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
5	to	to	PART	TO	_	_	_	_	_
6	be	be	AUX	VB	VerbForm=Inf	_	_	_	_
7	restricted	restrict	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
8	to	to	ADP	IN	_	_	_	_	_
9	tissues	tissue	NOUN	NNS	Number=Plur	_	_	_	_
10	enriched	enrich	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
11	in	in	ADP	IN	_	_	_	_	_
12	lymphocytes	lymphocyte	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
13	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3347
# text = DR3 signal transduction is mediated by a complex of intracellular signaling molecules including TRADD, TRAF2, FADD, and FLICE.
1	DR3	DR3	NOUN	NN	Number=Sing	_	_	_	_
2	signal	signal	NOUN	NN	Number=Sing	_	_	_	_
3	transduction	transduction	NOUN	NN	Number=Sing	_	_	_	_
4	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
5	mediated	mediate	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
6	by	by	ADP	IN	_	_	_	_	_
7	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
8	complex	complex	NOUN	NN	Number=Sing	_	_	_	_
9	of	of	ADP	IN	_	_	_	_	_
10	intracellular	intracelular	ADJ	JJ	Degree=Pos	_	_	_	_
11	signaling	signal	NOUN	NN	Number=Sing	_	_	_	_
12	molecules	molecule	NOUN	NNS	Number=Plur	_	_	_	_
13	including	include	VERB	VBG	VerbForm=Ger	_	_	_	_
14	TRADD	tRADd	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
15	,	,	PUNCT	,	_	_	_	_	_
16	TRAF2	Traf2	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
17	,	,	PUNCT	,	_	_	_	_	_
18	FADD	fadd	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
19	,	,	PUNCT	,	_	_	_	_	_
20	and	and	CCONJ	CC	_	_	_	_	_
21	FLICE	FLICE	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
22	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3348
# text = Thus, DR3 likely plays a role in regulating lymphocyte homeostasis.
1	Thus	thus	ADV	RB	_	_	_	_	SpaceAfter=No
2	,	,	PUNCT	,	_	_	_	_	_
3	DR3	DR3	NUM	CD	NumType=Card	_	_	_	_
4	likely	likely	ADV	RB	_	_	_	_	_
5	plays	play	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
6	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
7	role	role	NOUN	NN	Number=Sing	_	_	_	_
8	in	in	SCONJ	IN	_	_	_	_	_
9	regulating	regulate	VERB	VBG	VerbForm=Ger	_	_	_	_
10	lymphocyte	lymphocyte	ADJ	JJ	Degree=Pos	_	_	_	_
11	homeostasis	homeostasis	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
12	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 3349
# text = Document 003003452 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	003003452	003003452	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 3350
# text = In vivo modulation of glucocorticoid receptor mRNA by inhaled fluticasone propionate in bronchial mucosa and blood lymphocytes in subjects with mild asthma.
1	In	in	ADP	IN	_	_	_	_	_
2	vivo	vivo	ADJ	JJ	Degree=Pos	_	_	_	_
3	modulation	modulation	NOUN	NN	Number=Sing	_	_	_	_
4	of	of	ADP	IN	_	_	_	_	_
5	glucocorticoid	glucocorticoid	ADJ	JJ	Degree=Pos	_	_	_	_
6	receptor	receptor	NOUN	NN	Number=Sing	_	_	_	_
7	mRNA	mRNa	NOUN	NN	Number=Sing	_	_	_	_
8	by	by	ADP	IN	_	_	_	_	_
9	inhaled	inhal	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
10	fluticasone	fluticasone	NOUN	NN	Number=Sing	_	_	_	_
11	propionate	propionate	NOUN	NN	Number=Sing	_	_	_	_
12	in	in	ADP	IN	_	_	_	_	_
13	bronchial	bronchial	ADJ	JJ	Degree=Pos	_	_	_	_
14	mucosa	mucosa	NOUN	NN	Number=Sing	_	_	_	_
15	and	and	CCONJ	CC	_	_	_	_	_
16	blood	blood	NOUN	NN	Number=Sing	_	_	_	_
17	lymphocytes	lymphocyte	NOUN	NNS	Number=Plur	_	_	_	_
18	in	in	ADP	IN	_	_	_	_	_
19	subjects	subject	NOUN	NNS	Number=Plur	_	_	_	_
20	with	with	ADP	IN	_	_	_	_	_
21	mild	mild	ADJ	JJ	Degree=Pos	_	_	_	_
22	asthma	asthma	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
23	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 3351
# text = BACKGROUND: In vivo regulation of the glucocorticoid receptor (GR) by glucocorticoids provides a means of modulating sensitivity of targeted cells.
1	BACKGROUND	background	ADP	IN	_	_	_	_	SpaceAfter=No
2	:	:	PUNCT	:	_	_	_	_	_
3	In	in	ADP	IN	_	_	_	_	_
4	vivo	vivo	ADJ	JJ	Degree=Pos	_	_	_	_
5	regulation	regulation	NOUN	NN	Number=Sing	_	_	_	_
6	of	of	ADP	IN	_	_	_	_	_
7	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
8	glucocorticoid	glucocorticoid	ADJ	JJ	Degree=Pos	_	_	_	_
9	receptor	receptor	NOUN	NN	Number=Sing	_	_	_	_
10	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
11	GR	GR	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
12	)	)	PUNCT	-RRB-	_	_	_	_	_
13	by	by	ADP	IN	_	_	_	_	_
14	glucocorticoids	glucocorticoid	NOUN	NNS	Number=Plur	_	_	_	_
15	provides	provide	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
16	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
17	means	means	NOUN	NN	Number=Sing	_	_	_	_
18	of	of	SCONJ	IN	_	_	_	_	_
19	modulating	modulat	VERB	VBG	VerbForm=Ger	_	_	_	_
20	sensitivity	sensitivity	NOUN	NN	Number=Sing	_	_	_	_
21	of	of	ADP	IN	_	_	_	_	_
22	targeted	target	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
23	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
24	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3352
# text = OBJECTIVE:
1	OBJECTIVE	objective	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
2	:	:	PUNCT	:	_	_	_	_	_

# sent_id = 3353
# text = We sought to determine the in vivo modulation of GR mRNA expression by fluticasone propionate (FP) in subjects with mild asthma.
1	We	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
2	sought	seek	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
3	to	to	PART	TO	_	_	_	_	_
4	determine	determine	VERB	VB	VerbForm=Inf	_	_	_	_
5	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
6	in	in	ADP	IN	_	_	_	_	_
7	vivo	vivo	NOUN	NN	Number=Sing	_	_	_	_
8	modulation	modulation	NOUN	NN	Number=Sing	_	_	_	_
9	of	of	ADP	IN	_	_	_	_	_
10	GR	GR	PROPN	NNP	Number=Sing	_	_	_	_
11	mRNA	mRNA	PROPN	NNP	Number=Sing	_	_	_	_
12	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
13	by	by	ADP	IN	_	_	_	_	_
14	fluticasone	fluticasone	ADJ	JJ	Degree=Pos	_	_	_	_
15	propionate	propionate	NOUN	NN	Number=Sing	_	_	_	_
16	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
17	FP	Fp	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
18	)	)	PUNCT	-RRB-	_	_	_	_	_
19	in	in	ADP	IN	_	_	_	_	_
20	subjects	subject	NOUN	NNS	Number=Plur	_	_	_	_
21	with	with	ADP	IN	_	_	_	_	_
22	mild	mild	ADJ	JJ	Degree=Pos	_	_	_	_
23	asthma	asthma	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
24	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3354
# text = METHODS: Ten atopic asthmatic subjects were treated with FP 250 microg twice daily for 4 weeks.
1	METHODS	method	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
2	:	:	PUNCT	:	_	_	_	_	_
3	Ten	ten	NUM	CD	NumType=Card	_	_	_	_
4	atopic	atopic	ADJ	JJ	Degree=Pos	_	_	_	_
5	asthmatic	asthmatic	ADJ	JJ	Degree=Pos	_	_	_	_
6	subjects	subject	NOUN	NNS	Number=Plur	_	_	_	_
7	were	be	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
8	treated	treat	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
9	with	with	ADP	IN	_	_	_	_	_
10	FP	Fp	NOUN	NN	Number=Sing	_	_	_	_
11	250	250	NUM	CD	NumType=Card	_	_	_	_
12	microg	microg	NOUN	NN	Number=Sing	_	_	_	_
13	twice	twice	ADV	RB	NumType=Mult	_	_	_	_
14	daily	daily	ADV	RB	_	_	_	_	_
15	for	for	ADP	IN	_	_	_	_	_
16	4	4	NUM	CD	NumType=Card	_	_	_	_
17	weeks	week	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
18	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3355
# text = Before and after treatment, the patients underwent fiberoptic bronchoscopy with endobronchial biopsy and sampling of venous blood for measurements of GR mRNA levels.
1	Before	before	ADP	IN	_	_	_	_	_
2	and	and	CCONJ	CC	_	_	_	_	_
3	after	after	ADP	IN	_	_	_	_	_
4	treatment	treatment	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
5	,	,	PUNCT	,	_	_	_	_	_
6	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
7	patients	patient	NOUN	NNS	Number=Plur	_	_	_	_
8	underwent	underwent	ADJ	JJ	Degree=Pos	_	_	_	_
9	fiberoptic	fiberoptic	ADJ	JJ	Degree=Pos	_	_	_	_
10	bronchoscopy	bronchoscopy	NOUN	NN	Number=Sing	_	_	_	_
11	with	with	ADP	IN	_	_	_	_	_
12	endobronchial	endobronchial	ADJ	JJ	Degree=Pos	_	_	_	_
13	biopsy	biopsy	NOUN	NN	Number=Sing	_	_	_	_
14	and	and	CCONJ	CC	_	_	_	_	_
15	sampling	sampling	NOUN	NN	Number=Sing	_	_	_	_
16	of	of	ADP	IN	_	_	_	_	_
17	venous	venous	ADJ	JJ	Degree=Pos	_	_	_	_
18	blood	blood	NOUN	NN	Number=Sing	_	_	_	_
19	for	for	ADP	IN	_	_	_	_	_
20	measurements	measurement	NOUN	NNS	Number=Plur	_	_	_	_
21	of	of	ADP	IN	_	_	_	_	_
22	GR	GR	PROPN	NNP	Number=Sing	_	_	_	_
23	mRNA	mRNA	PROPN	NNP	Number=Sing	_	_	_	_
24	levels	level	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
25	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3356
# text = A solution hybridization assay was used for quantitative analysis of GR mRNA.
1	A	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
2	solution	solution	NOUN	NN	Number=Sing	_	_	_	_
3	hybridization	hybridization	NOUN	NN	Number=Sing	_	_	_	_
4	assay	assay	NOUN	NN	Number=Sing	_	_	_	_
5	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
6	used	use	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
7	for	for	ADP	IN	_	_	_	_	_
8	quantitative	quantitative	ADJ	JJ	Degree=Pos	_	_	_	_
9	analysis	analysis	NOUN	NN	Number=Sing	_	_	_	_
10	of	of	ADP	IN	_	_	_	_	_
11	GR	GR	PROPN	NNP	Number=Sing	_	_	_	_
12	mRNA	mRNA	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
13	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3357
# text = In addition, a 24-hour urinary cortisol excretion and an adrenocorticotropic hormone test before and after treatment with FP were performed.
1	In	in	ADP	IN	_	_	_	_	_
2	addition	addition	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
3	,	,	PUNCT	,	_	_	_	_	_
4	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
5	24	24	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
6	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
7	hour	hour	NOUN	NN	Number=Sing	_	_	_	_
8	urinary	urinary	ADJ	JJ	Degree=Pos	_	_	_	_
9	cortisol	cortisol	NOUN	NN	Number=Sing	_	_	_	_
10	excretion	excretion	NOUN	NN	Number=Sing	_	_	_	_
11	and	and	CCONJ	CC	_	_	_	_	_
12	an	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
13	adrenocorticotropic	adrenocorticotropic	ADJ	JJ	Degree=Pos	_	_	_	_
14	hormone	hormone	NOUN	NN	Number=Sing	_	_	_	_
15	test	test	NOUN	NN	Number=Sing	_	_	_	_
16	before	before	ADP	IN	_	_	_	_	_
17	and	and	CCONJ	CC	_	_	_	_	_
18	after	after	ADP	IN	_	_	_	_	_
19	treatment	treatment	NOUN	NN	Number=Sing	_	_	_	_
20	with	with	ADP	IN	_	_	_	_	_
21	FP	FP	PROPN	NNP	Number=Sing	_	_	_	_
22	were	be	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
23	performed	perform	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	SpaceAfter=No
24	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3358
# text = RESULTS: A high interindividual variation in GR mRNA expression was seen.
1	RESULTS	result	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
2	:	:	PUNCT	:	_	_	_	_	_
3	A	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
4	high	high	ADJ	JJ	Degree=Pos	_	_	_	_
5	interindividual	interindividual	ADJ	JJ	Degree=Pos	_	_	_	_
6	variation	variation	NOUN	NN	Number=Sing	_	_	_	_
7	in	in	ADP	IN	_	_	_	_	_
8	GR	GR	PROPN	NNP	Number=Sing	_	_	_	_
9	mRNA	mRNA	PROPN	NNP	Number=Sing	_	_	_	_
10	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
11	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
12	seen	see	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	SpaceAfter=No
13	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3359
# text = However, we detected a significant reduction of the GR mRNA levels in the endobronchial biopsy specimens after FP treatment (36.6 +/- 23.1 and 25.0 +/- 10.9 amol GR mRNA/microg RNA, respectively; P <.01).
1	However	however	ADV	RB	_	_	_	_	SpaceAfter=No
2	,	,	PUNCT	,	_	_	_	_	_
3	we	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
4	detected	detect	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
5	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
6	significant	significant	ADJ	JJ	Degree=Pos	_	_	_	_
7	reduction	reduction	NOUN	NN	Number=Sing	_	_	_	_
8	of	of	ADP	IN	_	_	_	_	_
9	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
10	GR	GR	PROPN	NNP	Number=Sing	_	_	_	_
11	mRNA	mRNA	PROPN	NNP	Number=Sing	_	_	_	_
12	levels	level	NOUN	NNS	Number=Plur	_	_	_	_
13	in	in	ADP	IN	_	_	_	_	_
14	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
15	endobronchial	endobronchial	ADJ	JJ	Degree=Pos	_	_	_	_
16	biopsy	biopsy	NOUN	NN	Number=Sing	_	_	_	_
17	specimens	specimen	NOUN	NNS	Number=Plur	_	_	_	_
18	after	after	ADP	IN	_	_	_	_	_
19	FP	Fp	NOUN	NN	Number=Sing	_	_	_	_
20	treatment	treatment	NOUN	NN	Number=Sing	_	_	_	_
21	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
22	36.6	36.6	NUM	CD	NumType=Card	_	_	_	_
23	+/-	+/-	SYM	SYM	_	_	_	_	_
24	23.1	23.1	NUM	CD	NumType=Card	_	_	_	_
25	and	and	CCONJ	CC	_	_	_	_	_
26	25.0	25.0	NUM	CD	NumType=Card	_	_	_	_
27	+/-	+/-	SYM	SYM	_	_	_	_	_
28	10.9	10.9	NUM	CD	NumType=Card	_	_	_	_
29	amol	amol	NOUN	NN	Number=Sing	_	_	_	_
30	GR	GR	PROPN	NNP	Number=Sing	_	_	_	_
31	mRNA	mRNA	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
32	/	/	PUNCT	,	_	_	_	_	SpaceAfter=No
33	microg	microg	PROPN	NNP	Number=Sing	_	_	_	_
34	RNA	RNA	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
35	,	,	PUNCT	,	_	_	_	_	_
36	respectively	respectively	ADV	RB	_	_	_	_	SpaceAfter=No
37	;	;	PUNCT	,	_	_	_	_	_
38	P	p	PROPN	NNP	Number=Sing	_	_	_	_
39	<	<	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
40	.01	.01	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
41	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
42	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3360
# text = In the peripheral blood lymphocytes an even more striking downregulation of the GR by its cognate ligand was documented (30.3 +/- 26.5 and 8.8 +/- 5 amol GR mRNA/microg RNA, respectively; P <.001), possibly reflecting differences in glucocorticoid sensitivity between tissues.
1	In	in	ADP	IN	_	_	_	_	_
2	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
3	peripheral	peripheral	ADJ	JJ	Degree=Pos	_	_	_	_
4	blood	blood	NOUN	NN	Number=Sing	_	_	_	_
5	lymphocytes	lymphocyte	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
6	an	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
7	even	even	ADV	RB	_	_	_	_	_
8	more	more	ADV	RBR	_	_	_	_	_
9	striking	strik	VERB	VBG	VerbForm=Ger	_	_	_	_
10	downregulation	downregulation	NOUN	NN	Number=Sing	_	_	_	_
11	of	of	ADP	IN	_	_	_	_	_
12	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
13	GR	Gr	PROPN	NNP	Number=Sing	_	_	_	_
14	by	by	ADP	IN	_	_	_	_	_
15	its	its	PRON	PRP$	Gender=Neut|Number=Sing|Person=3|Poss=Yes|PronType=Prs	_	_	_	_
16	cognate	cognate	ADJ	JJ	Degree=Pos	_	_	_	_
17	ligand	ligand	NOUN	NN	Number=Sing	_	_	_	_
18	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
19	documented	document	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
20	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
21	30.3	30.3	NUM	CD	NumType=Card	_	_	_	_
22	+/-	+/-	SYM	SYM	_	_	_	_	_
23	26.5	26.5	NUM	CD	NumType=Card	_	_	_	_
24	and	and	CCONJ	CC	_	_	_	_	_
25	8.8	8.8	NUM	CD	NumType=Card	_	_	_	_
26	+/-	+/-	SYM	SYM	_	_	_	_	_
27	5	5	NUM	CD	NumType=Card	_	_	_	_
28	amol	amol	NOUN	NN	Number=Sing	_	_	_	_
29	GR	GR	PROPN	NNP	Number=Sing	_	_	_	_
30	mRNA	mRNA	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
31	/	/	PUNCT	,	_	_	_	_	SpaceAfter=No
32	microg	microg	NOUN	NN	Number=Sing	_	_	_	_
33	RNA	RNa	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
34	,	,	PUNCT	,	_	_	_	_	_
35	respectively	respectively	ADV	RB	_	_	_	_	SpaceAfter=No
36	;	;	PUNCT	,	_	_	_	_	_
37	P	P	PROPN	NNP	Number=Sing	_	_	_	_
38	<	<	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
39	.001	.001	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
40	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
41	,	,	PUNCT	,	_	_	_	_	_
42	possibly	possibly	ADV	RB	_	_	_	_	_
43	reflecting	reflect	VERB	VBG	VerbForm=Ger	_	_	_	_
44	differences	difference	NOUN	NNS	Number=Plur	_	_	_	_
45	in	in	ADP	IN	_	_	_	_	_
46	glucocorticoid	glucocorticoid	ADJ	JJ	Degree=Pos	_	_	_	_
47	sensitivity	sensitivity	NOUN	NN	Number=Sing	_	_	_	_
48	between	between	ADP	IN	_	_	_	_	_
49	tissues	tissue	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
50	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3361
# text = A small but significant reduction of the 24-hour urinary cortisol excretion was observed (233 +/- 109 and 157 +/- 66 nmol/L, respectively; P <.01), whereas the feedback regulation of glucocorticoid synthesis by means of the hypothalamic-pituitary-adrenal axis as assessed by the adrenocorticotropic hormone test remained normal after treatment with FP.
1	A	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
2	small	small	ADJ	JJ	Degree=Pos	_	_	_	_
3	but	but	CCONJ	CC	_	_	_	_	_
4	significant	significant	ADJ	JJ	Degree=Pos	_	_	_	_
5	reduction	reduction	NOUN	NN	Number=Sing	_	_	_	_
6	of	of	ADP	IN	_	_	_	_	_
7	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
8	24	24	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
9	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
10	hour	hour	NOUN	NN	Number=Sing	_	_	_	_
11	urinary	urinary	ADJ	JJ	Degree=Pos	_	_	_	_
12	cortisol	cortisol	NOUN	NN	Number=Sing	_	_	_	_
13	excretion	excretion	NOUN	NN	Number=Sing	_	_	_	_
14	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
15	observed	observe	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
16	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
17	233	233	NUM	CD	NumType=Card	_	_	_	_
18	+/-	+/-	SYM	SYM	_	_	_	_	_
19	109	109	NUM	CD	NumType=Card	_	_	_	_
20	and	and	CCONJ	CC	_	_	_	_	_
21	157	157	NUM	CD	NumType=Card	_	_	_	_
22	+/-	+/-	SYM	SYM	_	_	_	_	_
23	66	66	NUM	CD	NumType=Card	_	_	_	_
24	nmol/L	nmol/l	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
25	,	,	PUNCT	,	_	_	_	_	_
26	respectively	respectively	ADV	RB	_	_	_	_	SpaceAfter=No
27	;	;	PUNCT	,	_	_	_	_	_
28	P	P	PROPN	NNP	Number=Sing	_	_	_	_
29	<	<	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
30	.01	.01	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
31	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
32	,	,	PUNCT	,	_	_	_	_	_
33	whereas	whereas	SCONJ	IN	_	_	_	_	_
34	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
35	feedback	feedback	NOUN	NN	Number=Sing	_	_	_	_
36	regulation	regulation	NOUN	NN	Number=Sing	_	_	_	_
37	of	of	ADP	IN	_	_	_	_	_
38	glucocorticoid	glucocorticoid	ADJ	JJ	Degree=Pos	_	_	_	_
39	synthesis	synthesis	NOUN	NN	Number=Sing	_	_	_	_
40	by	by	ADP	IN	_	_	_	_	_
41	means	means	NOUN	NNS	Number=Plur	_	_	_	_
42	of	of	ADP	IN	_	_	_	_	_
43	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
44	hypothalamic	hypothalamic	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
45	-pituitary	-pituitary	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
46	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
47	adrenal	adrenal	ADJ	JJ	Degree=Pos	_	_	_	_
48	axis	axis	NOUN	NN	Number=Sing	_	_	_	_
49	as	as	SCONJ	IN	_	_	_	_	_
50	assessed	assess	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
51	by	by	ADP	IN	_	_	_	_	_
52	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
53	adrenocorticotropic	adrenocorticotropic	ADJ	JJ	Degree=Pos	_	_	_	_
54	hormone	hormone	NOUN	NN	Number=Sing	_	_	_	_
55	test	test	NOUN	NN	Number=Sing	_	_	_	_
56	remained	remain	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
57	normal	normal	ADJ	JJ	Degree=Pos	_	_	_	_
58	after	after	ADP	IN	_	_	_	_	_
59	treatment	treatment	NOUN	NN	Number=Sing	_	_	_	_
60	with	with	ADP	IN	_	_	_	_	_
61	FP	FP	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
62	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3362
# text = CONCLUSION:
1	CONCLUSION	conclusion	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
2	:	:	PUNCT	:	_	_	_	_	_

# sent_id = 3363
# text = The results in this study confirm the potency of the inhaled corticosteroid FP and provide evidence for a considerable tissue-specific interindividual variation in the expression of the GR.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	results	result	NOUN	NNS	Number=Plur	_	_	_	_
3	in	in	ADP	IN	_	_	_	_	_
4	this	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
5	study	study	NOUN	NN	Number=Sing	_	_	_	_
6	confirm	confirm	VERB	VB	VerbForm=Inf	_	_	_	_
7	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
8	potency	potency	NOUN	NN	Number=Sing	_	_	_	_
9	of	of	ADP	IN	_	_	_	_	_
10	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
11	inhaled	inhal	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
12	corticosteroid	corticosteroid	NOUN	NN	Number=Sing	_	_	_	_
13	FP	Fp	NOUN	NN	Number=Sing	_	_	_	_
14	and	and	CCONJ	CC	_	_	_	_	_
15	provide	provide	VERB	VB	VerbForm=Inf	_	_	_	_
16	evidence	evidence	NOUN	NN	Number=Sing	_	_	_	_
17	for	for	ADP	IN	_	_	_	_	_
18	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
19	considerable	considerable	ADJ	JJ	Degree=Pos	_	_	_	_
20	tissue-	tissue-	PUNCT	,	_	_	_	_	SpaceAfter=No
21	specific	specific	ADJ	JJ	Degree=Pos	_	_	_	_
22	interindividual	interindividual	ADJ	JJ	Degree=Pos	_	_	_	_
23	variation	variation	NOUN	NN	Number=Sing	_	_	_	_
24	in	in	ADP	IN	_	_	_	_	_
25	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
26	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
27	of	of	ADP	IN	_	_	_	_	_
28	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
29	GR.	GR.	PROPN	NNP	Number=Sing	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 3364
# text = Document 003003454 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	003003454	003003454	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 3365
# text = Multiple NF-ATc isoforms with individual transcriptional properties are synthesized in T lymphocytes.
1	Multiple	multiple	PROPN	NNP	Number=Sing	_	_	_	_
2	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
3	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
4	ATc	ATc	PROPN	NNP	Number=Sing	_	_	_	_
5	isoforms	isoform	NOUN	NNS	Number=Plur	_	_	_	_
6	with	with	ADP	IN	_	_	_	_	_
7	individual	individual	ADJ	JJ	Degree=Pos	_	_	_	_
8	transcriptional	transcriptional	ADJ	JJ	Degree=Pos	_	_	_	_
9	properties	property	NOUN	NNS	Number=Plur	_	_	_	_
10	are	be	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
11	synthesized	synthesize	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
12	in	in	ADP	IN	_	_	_	_	_
13	T	t	PROPN	NNP	Number=Sing	_	_	_	_
14	lymphocytes	lymphocyte	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
15	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 3366
# text = The transcription factor NF-ATc that controls gene expression in T lymphocytes and embryonic cardiac cells is expressed in three prominent isoforms.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
3	factor	factor	NOUN	NN	Number=Sing	_	_	_	_
4	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
5	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
6	ATc	ATc	PROPN	NNP	Number=Sing	_	_	_	_
7	that	that	PRON	WDT	PronType=Rel	_	_	_	_
8	controls	control	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
9	gene	gene	ADJ	JJ	Degree=Pos	_	_	_	_
10	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
11	in	in	ADP	IN	_	_	_	_	_
12	T	t	PROPN	NNP	Number=Sing	_	_	_	_
13	lymphocytes	lymphocyte	NOUN	NNS	Number=Plur	_	_	_	_
14	and	and	CCONJ	CC	_	_	_	_	_
15	embryonic	embryonic	ADJ	JJ	Degree=Pos	_	_	_	_
16	cardiac	cardiac	ADJ	JJ	Degree=Pos	_	_	_	_
17	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
18	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
19	expressed	express	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
20	in	in	ADP	IN	_	_	_	_	_
21	three	three	NUM	CD	NumType=Card	_	_	_	_
22	prominent	prominent	ADJ	JJ	Degree=Pos	_	_	_	_
23	isoforms	isoform	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
24	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3367
# text = This is due to alternative splice/polyadenylation events that lead to the predominant synthesis of two long isoforms in naive T cells and a shorter NF-ATc isoform in effector T cells.
1	This	this	PRON	DT	Number=Sing|PronType=Dem	_	_	_	_
2	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
3	due	due	ADP	IN	_	_	_	_	_
4	to	to	ADP	IN	_	_	_	_	_
5	alternative	alternative	ADJ	JJ	Degree=Pos	_	_	_	_
6	splice	splice	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
7	/	/	PUNCT	,	_	_	_	_	SpaceAfter=No
8	polyadenylation	polyadenylation	NOUN	NN	Number=Sing	_	_	_	_
9	events	event	NOUN	NNS	Number=Plur	_	_	_	_
10	that	that	PRON	WDT	PronType=Rel	_	_	_	_
11	lead	lead	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
12	to	to	ADP	IN	_	_	_	_	_
13	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
14	predominant	predominant	ADJ	JJ	Degree=Pos	_	_	_	_
15	synthesis	synthesis	NOUN	NN	Number=Sing	_	_	_	_
16	of	of	ADP	IN	_	_	_	_	_
17	two	two	NUM	CD	NumType=Card	_	_	_	_
18	long	long	ADJ	JJ	Degree=Pos	_	_	_	_
19	isoforms	isoform	NOUN	NNS	Number=Plur	_	_	_	_
20	in	in	ADP	IN	_	_	_	_	_
21	naive	naive	ADJ	JJ	Degree=Pos	_	_	_	_
22	T	t	PROPN	NNP	Number=Sing	_	_	_	_
23	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
24	and	and	CCONJ	CC	_	_	_	_	_
25	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
26	shorter	shorter	NOUN	NN	Number=Sing	_	_	_	_
27	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
28	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
29	ATc	ATc	PROPN	NNP	Number=Sing	_	_	_	_
30	isoform	isoform	NOUN	NN	Number=Sing	_	_	_	_
31	in	in	ADP	IN	_	_	_	_	_
32	effector	effector	NOUN	NN	Number=Sing	_	_	_	_
33	T	t	PROPN	NNP	Number=Sing	_	_	_	_
34	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
35	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3368
# text = Whereas the previously described isoform NF-ATc/A contains a relatively short C terminus, the longer isoforms, B and C, span extra C-terminal peptides of 128 and 246 aa, respectively.
1	Whereas	whereas	SCONJ	IN	_	_	_	_	_
2	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
3	previously	previously	ADV	RB	_	_	_	_	_
4	described	describe	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
5	isoform	isoform	NOUN	NN	Number=Sing	_	_	_	_
6	NF	Nf	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
7	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
8	ATc/	Atc/	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
9	A	a	NOUN	NN	Number=Sing	_	_	_	_
10	contains	contain	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
11	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
12	relatively	relatively	ADV	RB	_	_	_	_	_
13	short	short	ADJ	JJ	Degree=Pos	_	_	_	_
14	C	c	PROPN	NNP	Number=Sing	_	_	_	_
15	terminus	terminus	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
16	,	,	PUNCT	,	_	_	_	_	_
17	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
18	longer	longer	ADJ	JJR	Degree=Cmp	_	_	_	_
19	isoforms	isoform	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
20	,	,	PUNCT	,	_	_	_	_	_
21	B	b	PROPN	NNP	Number=Sing	_	_	_	_
22	and	and	CCONJ	CC	_	_	_	_	_
23	C	c	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
24	,	,	PUNCT	,	_	_	_	_	_
25	span	span	ADJ	JJ	Degree=Pos	_	_	_	_
26	extra	extra	ADJ	JJ	Degree=Pos	_	_	_	_
27	C	c	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
28	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
29	terminal	terminal	ADJ	JJ	Degree=Pos	_	_	_	_
30	peptides	peptide	NOUN	NNS	Number=Plur	_	_	_	_
31	of	of	ADP	IN	_	_	_	_	_
32	128	128	NUM	CD	NumType=Card	_	_	_	_
33	and	and	CCONJ	CC	_	_	_	_	_
34	246	246	NUM	CD	NumType=Card	_	_	_	_
35	aa	aa	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
36	,	,	PUNCT	,	_	_	_	_	_
37	respectively	respectively	ADV	RB	_	_	_	_	SpaceAfter=No
38	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3369
# text = We show here that in addition to the strong N-terminal trans-activation domain, TAD-A, which is common to all three NF-ATc isoforms, NF-ATc/C contains a second trans-activation domain, TAD-B, in its C-terminal peptide.
1	We	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
2	show	show	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
3	here	here	ADV	RB	PronType=Dem	_	_	_	_
4	that	that	SCONJ	IN	_	_	_	_	_
5	in	in	ADP	IN	_	_	_	_	_
6	addition	addition	NOUN	NN	Number=Sing	_	_	_	_
7	to	to	ADP	IN	_	_	_	_	_
8	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
9	strong	strong	ADJ	JJ	Degree=Pos	_	_	_	_
10	N-	n-	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
11	terminal	terminal	NOUN	NN	Number=Sing	_	_	_	_
12	trans-	trans-	SYM	SYM	_	_	_	_	SpaceAfter=No
13	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
14	domain	domain	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
15	,	,	PUNCT	,	_	_	_	_	_
16	TAD	tAd	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
17	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
18	A	a	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
19	,	,	PUNCT	,	_	_	_	_	_
20	which	which	PRON	WDT	PronType=Rel	_	_	_	_
21	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
22	common	common	ADJ	JJ	Degree=Pos	_	_	_	_
23	to	to	ADP	IN	_	_	_	_	_
24	all	all	DET	DT	_	_	_	_	_
25	three	three	NUM	CD	NumType=Card	_	_	_	_
26	NF	NF	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
27	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
28	ATc	ATc	NOUN	NN	Number=Sing	_	_	_	_
29	isoforms	isoform	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
30	,	,	PUNCT	,	_	_	_	_	_
31	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
32	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
33	ATc/	ATcith	ADP	IN	Abbr=Yes	_	_	_	SpaceAfter=No
34	C	C	PROPN	NNP	Number=Sing	_	_	_	_
35	contains	contain	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
36	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
37	second	second	ADJ	JJ	Degree=Pos|NumType=Ord	_	_	_	_
38	trans-	trans-	SYM	NFP	_	_	_	_	SpaceAfter=No
39	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
40	domain	domain	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
41	,	,	PUNCT	,	_	_	_	_	_
42	TAD	tAd	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
43	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
44	B	b	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
45	,	,	PUNCT	,	_	_	_	_	_
46	in	in	ADP	IN	_	_	_	_	_
47	its	its	PRON	PRP$	Gender=Neut|Number=Sing|Person=3|Poss=Yes|PronType=Prs	_	_	_	_
48	C-	C-	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
49	terminal	terminal	ADJ	JJ	Degree=Pos	_	_	_	_
50	peptide	peptide	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
51	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3370
# text = Various stimuli of T cells that induce the activity of TAD-A also enhance the activity of TAD-B, but, unlike TAD-A, TAD-B remains unphosphorylated by protein from 12-O-tetradecanoyl 12-phorbol 13-acetate-stimulated T cells.
1	Various	various	ADJ	JJ	Degree=Pos	_	_	_	_
2	stimuli	stimuli	NOUN	NN	Number=Sing	_	_	_	_
3	of	of	ADP	IN	_	_	_	_	_
4	T	t	PROPN	NNP	Number=Sing	_	_	_	_
5	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
6	that	that	PRON	WDT	PronType=Rel	_	_	_	_
7	induce	induce	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
8	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
9	activity	activity	NOUN	NN	Number=Sing	_	_	_	_
10	of	of	ADP	IN	_	_	_	_	_
11	TAD	TAD	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
12	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
13	A	A	PROPN	NNP	Number=Sing	_	_	_	_
14	also	also	ADV	RB	_	_	_	_	_
15	enhance	enhance	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
16	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
17	activity	activity	NOUN	NN	Number=Sing	_	_	_	_
18	of	of	ADP	IN	_	_	_	_	_
19	TAD	tAd	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
20	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
21	B	b	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
22	,	,	PUNCT	,	_	_	_	_	_
23	but	but	CCONJ	CC	_	_	_	_	SpaceAfter=No
24	,	,	PUNCT	,	_	_	_	_	_
25	unlike	unlike	ADP	IN	_	_	_	_	_
26	TAD	tAd	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
27	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
28	A	a	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
29	,	,	PUNCT	,	_	_	_	_	_
30	TAD	tAd	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
31	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
32	B	b	NOUN	NN	Number=Sing	_	_	_	_
33	remains	remains	NOUN	NNS	Number=Plur	_	_	_	_
34	unphosphorylated	unphosphorylate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
35	by	by	ADP	IN	_	_	_	_	_
36	protein	protein	NOUN	NN	Number=Sing	_	_	_	_
37	from	from	ADP	IN	_	_	_	_	_
38	12	12	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
39	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
40	O	of	ADP	IN	Abbr=Yes	_	_	_	SpaceAfter=No
41	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
42	tetradecanoyl	tetradecanoyl	NOUN	NN	Number=Sing	_	_	_	_
43	12	12	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
44	-	-	PUNCT	:	_	_	_	_	SpaceAfter=No
45	phorbol	phorbol	NOUN	NN	Number=Sing	_	_	_	_
46	13	13	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
47	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
48	acetate	acetate	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
49	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
50	stimulated	stimulate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
51	T	t	PROPN	NNP	Number=Sing	_	_	_	_
52	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
53	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3371
# text = The shorter C-terminal peptide of isoform NF-ATc/B exerts a suppressive transcriptional effect.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	shorter	shorter	NOUN	NN	Number=Sing	_	_	_	_
3	C-	C-	PUNCT	,	_	_	_	_	SpaceAfter=No
4	terminal	terminal	ADJ	JJ	Degree=Pos	_	_	_	_
5	peptide	peptide	NOUN	NN	Number=Sing	_	_	_	_
6	of	of	ADP	IN	_	_	_	_	_
7	isoform	isoform	NOUN	NN	Number=Sing	_	_	_	_
8	NF	NF	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
9	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
10	ATc/	ATc/	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
11	B	b	NOUN	NN	Number=Sing	_	_	_	_
12	exerts	exert	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
13	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
14	suppressive	suppressive	ADJ	JJ	Degree=Pos	_	_	_	_
15	transcriptional	transcriptional	ADJ	JJ	Degree=Pos	_	_	_	_
16	effect	effect	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
17	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3372
# text = These properties of NF-ATc/B and -C might be of importance for gene regulation in naive T lymphocytes in which NF-ATc/B and -C are predominantly synthesized.
1	These	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
2	properties	property	NOUN	NNS	Number=Plur	_	_	_	_
3	of	of	ADP	IN	_	_	_	_	_
4	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
5	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
6	ATc/B	ATc/B	PROPN	NNP	Number=Sing	_	_	_	_
7	and	and	CCONJ	CC	_	_	_	_	_
8	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
9	C	C	PROPN	NNP	Number=Sing	_	_	_	_
10	might	might	AUX	MD	VerbForm=Fin	_	_	_	_
11	be	be	AUX	VB	VerbForm=Inf	_	_	_	_
12	of	of	ADP	IN	_	_	_	_	_
13	importance	importance	NOUN	NN	Number=Sing	_	_	_	_
14	for	for	ADP	IN	_	_	_	_	_
15	gene	gene	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
16	regulation	regulation	NOUN	NN	Number=Sing	_	_	_	_
17	in	in	ADP	IN	_	_	_	_	_
18	naive	naive	ADJ	JJ	Degree=Pos	_	_	_	_
19	T	t	PROPN	NNP	Number=Sing	_	_	_	_
20	lymphocytes	lymphocyte	NOUN	NNS	Number=Plur	_	_	_	_
21	in	in	ADP	IN	_	_	_	_	_
22	which	which	PRON	WDT	PronType=Rel	_	_	_	_
23	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
24	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
25	ATc/B	ATc/B	PROPN	NNP	Number=Sing	_	_	_	_
26	and	and	CCONJ	CC	_	_	_	_	_
27	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
28	C	C	PROPN	NNP	Number=Sing	_	_	_	_
29	are	be	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
30	predominantly	predominantly	ADV	RB	_	_	_	_	_
31	synthesized	synthesize	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	SpaceAfter=No
32	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 3373
# text = Document 003003456 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	003003456	003003456	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 3374
# text = Latent membrane protein-1 induces cyclin D2 expression, pRb hyperphosphorylation, and loss of TGF-beta 1-mediated growth inhibition in EBV-positive B cells.
1	Latent	Latent	ADJ	JJ	Degree=Pos	_	_	_	_
2	membrane	membrane	NOUN	NN	Number=Sing	_	_	_	_
3	protein	protein	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
4	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
5	1	1	NUM	CD	NumType=Card	_	_	_	_
6	induces	induce	NOUN	NNS	Number=Plur	_	_	_	_
7	cyclin	cyclin	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
8	D2	D2	NUM	CD	NumType=Card	_	_	_	_
9	expression	expression	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
10	,	,	PUNCT	,	_	_	_	_	_
11	pRb	pRb	NOUN	NN	Number=Sing	_	_	_	_
12	hyperphosphorylation	hyperphosphorylation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
13	,	,	PUNCT	,	_	_	_	_	_
14	and	and	CCONJ	CC	_	_	_	_	_
15	loss	loss	ADP	IN	_	_	_	_	_
16	of	of	ADP	IN	_	_	_	_	_
17	TGF	TGF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
18	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
19	beta	beta	NOUN	NN	Number=Sing	_	_	_	_
20	1	1	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
21	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
22	mediated	mediate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
23	growth	growth	NOUN	NN	Number=Sing	_	_	_	_
24	inhibition	inhibition	NOUN	NN	Number=Sing	_	_	_	_
25	in	in	ADP	IN	_	_	_	_	_
26	EBV	EBV	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
27	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
28	positive	positive	ADJ	JJ	Degree=Pos	_	_	_	_
29	B	b	ADJ	JJ	Degree=Pos	_	_	_	_
30	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
31	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 3375
# text = The normal cell cycle is regulated by several molecules, such as the tumor-suppressor protein pRb, the G1 cyclins, the cyclin-dependent kinases, and their inhibitors.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	normal	normal	ADJ	JJ	Degree=Pos	_	_	_	_
3	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
4	cycle	cycle	NOUN	NN	Number=Sing	_	_	_	_
5	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
6	regulated	regulate	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
7	by	by	ADP	IN	_	_	_	_	_
8	several	several	ADJ	JJ	Degree=Pos	_	_	_	_
9	molecules	molecule	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
10	,	,	PUNCT	,	_	_	_	_	_
11	such	such	ADJ	JJ	Degree=Pos	_	_	_	_
12	as	as	ADP	IN	_	_	_	_	_
13	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
14	tumor	tumor	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
15	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
16	suppressor	suppressor	NOUN	NN	Number=Sing	_	_	_	_
17	protein	protein	NOUN	NN	Number=Sing	_	_	_	_
18	pRb	pRb	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
19	,	,	PUNCT	,	_	_	_	_	_
20	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
21	G1	g1	NOUN	NN	Number=Sing	_	_	_	_
22	cyclins	cyclin	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
23	,	,	PUNCT	,	_	_	_	_	_
24	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
25	cyclin	cyclin	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
26	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
27	dependent	dependent	ADJ	JJ	Degree=Pos	_	_	_	_
28	kinases	kinase	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
29	,	,	PUNCT	,	_	_	_	_	_
30	and	and	CCONJ	CC	_	_	_	_	_
31	their	they	PRON	PRP$	Number=Plur|Person=3|Poss=Yes|PronType=Prs	_	_	_	_
32	inhibitors	inhibitor	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
33	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3376
# text = These regulators are targeted by negative growth regulatory signals, such as that provided by TGF-beta.
1	These	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
2	regulators	regulator	NOUN	NNS	Number=Plur	_	_	_	_
3	are	be	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
4	targeted	target	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
5	by	by	ADP	IN	_	_	_	_	_
6	negative	negative	ADJ	JJ	Degree=Pos	_	_	_	_
7	growth	growth	NOUN	NN	Number=Sing	_	_	_	_
8	regulatory	regulatory	ADJ	JJ	Degree=Pos	_	_	_	_
9	signals	signal	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
10	,	,	PUNCT	,	_	_	_	_	_
11	such	such	ADJ	JJ	Degree=Pos	_	_	_	_
12	as	as	ADP	IN	_	_	_	_	_
13	that	that	PRON	DT	Number=Sing|PronType=Dem	_	_	_	_
14	provided	provide	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
15	by	by	ADP	IN	_	_	_	_	_
16	TGF	TGF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
17	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
18	beta	beta	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
19	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3377
# text = Here, we show that the presence of either wild-type EBV or its transforming latent membrane protein-1 (LMP-1) results in the loss of TGF-beta 1-mediated growth inhibition in human B cells.
1	Here	here	ADV	RB	PronType=Dem	_	_	_	SpaceAfter=No
2	,	,	PUNCT	,	_	_	_	_	_
3	we	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
4	show	show	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
5	that	that	SCONJ	IN	_	_	_	_	_
6	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
7	presence	presence	NOUN	NN	Number=Sing	_	_	_	_
8	of	of	ADP	IN	_	_	_	_	_
9	either	either	CCONJ	CC	_	_	_	_	_
10	wild	wild	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
11	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
12	type	type	NOUN	NN	Number=Sing	_	_	_	_
13	EBV	Ebv	NOUN	NN	Number=Sing	_	_	_	_
14	or	or	CCONJ	CC	_	_	_	_	_
15	its	its	PRON	PRP$	Gender=Neut|Number=Sing|Person=3|Poss=Yes|PronType=Prs	_	_	_	_
16	transforming	transform	VERB	VBG	VerbForm=Ger	_	_	_	_
17	latent	latent	ADJ	JJ	Degree=Pos	_	_	_	_
18	membrane	membrane	NOUN	NN	Number=Sing	_	_	_	_
19	protein	protein	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
20	-1	-1	NUM	CD	NumType=Card	_	_	_	_
21	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
22	LMP	Lmp	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
23	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
24	1	1	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
25	)	)	PUNCT	-RRB-	_	_	_	_	_
26	results	result	NOUN	NNS	Number=Plur	_	_	_	_
27	in	in	ADP	IN	_	_	_	_	_
28	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
29	loss	loss	NOUN	NN	Number=Sing	_	_	_	_
30	of	of	ADP	IN	_	_	_	_	_
31	TGF	TGF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
32	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
33	beta	beta	NOUN	NN	Number=Sing	_	_	_	_
34	1	1	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
35	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
36	mediated	mediate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
37	growth	growth	NOUN	NN	Number=Sing	_	_	_	_
38	inhibition	inhibition	NOUN	NN	Number=Sing	_	_	_	_
39	in	in	ADP	IN	_	_	_	_	_
40	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
41	B	b	ADJ	JJ	Degree=Pos	_	_	_	_
42	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
43	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3378
# text = Chemical cross-linking with 125I-labeled TGF-beta 1 showed an essentially normal TGF-beta receptor profile in EBV-positive and EBV-negative Burkitt's lymphoma cell lines, and these receptors were shown to be functional in transducing signals, as evidenced by the TGF-beta 1-mediated modulation of junB gene expression.
1	Chemical	Chemical	PROPN	NNP	Number=Sing	_	_	_	_
2	cross	cross	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
3	-linking	-link	VERB	VBG	VerbForm=Ger	_	_	_	_
4	with	with	ADP	IN	_	_	_	_	_
5	125I	125I	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
6	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
7	labeled	label	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
8	TGF	Tgf	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
9	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
10	beta	beta	NOUN	NN	Number=Sing	_	_	_	_
11	1	1	NUM	CD	NumType=Card	_	_	_	_
12	showed	show	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
13	an	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
14	essentially	essentially	ADV	RB	_	_	_	_	_
15	normal	normal	ADJ	JJ	Degree=Pos	_	_	_	_
16	TGF	Tgf	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
17	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
18	beta	beta	NOUN	NN	Number=Sing	_	_	_	_
19	receptor	receptor	NOUN	NN	Number=Sing	_	_	_	_
20	profile	profile	NOUN	NN	Number=Sing	_	_	_	_
21	in	in	ADP	IN	_	_	_	_	_
22	EBV	EBV	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
23	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
24	positive	positive	ADJ	JJ	Degree=Pos	_	_	_	_
25	and	and	CCONJ	CC	_	_	_	_	_
26	EBV	EBV	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
27	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
28	negative	negative	ADJ	JJ	Degree=Pos	_	_	_	_
29	Burkitt	Burkitt	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
30	's	's	PART	POS	_	_	_	_	_
31	lymphoma	lymphoma	NOUN	NN	Number=Sing	_	_	_	_
32	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
33	lines	line	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
34	,	,	PUNCT	,	_	_	_	_	_
35	and	and	CCONJ	CC	_	_	_	_	_
36	these	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
37	receptors	receptor	NOUN	NNS	Number=Plur	_	_	_	_
38	were	be	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
39	shown	show	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
40	to	to	PART	TO	_	_	_	_	_
41	be	be	AUX	VB	VerbForm=Inf	_	_	_	_
42	functional	functional	ADJ	JJ	Degree=Pos	_	_	_	_
43	in	in	SCONJ	IN	_	_	_	_	_
44	transducing	transduce	VERB	VBG	VerbForm=Ger	_	_	_	_
45	signals	signal	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
46	,	,	PUNCT	,	_	_	_	_	_
47	as	as	SCONJ	IN	_	_	_	_	_
48	evidenced	evidence	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
49	by	by	ADP	IN	_	_	_	_	_
50	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
51	TGF	TGF	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
52	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
53	beta	beta	NOUN	NN	Number=Sing	_	_	_	_
54	1	1	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
55	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
56	mediated	mediate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
57	modulation	modulation	NOUN	NN	Number=Sing	_	_	_	_
58	of	of	ADP	IN	_	_	_	_	_
59	junB	junB	PROPN	NNP	Number=Sing	_	_	_	_
60	gene	gene	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
61	expression	expression	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
62	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3379
# text = However, TGF-beta 1 did not induce dephosphorylation of pRb in EBV (or LMP-1)-positive cells as opposed to EBV-negative cells, suggesting a dichotomy in the TGF-beta 1 signaling pathway leading to separable gene regulatory and growth inhibitory responses.
1	However	however	ADV	RB	_	_	_	_	SpaceAfter=No
2	,	,	PUNCT	,	_	_	_	_	_
3	TGF	TGF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
4	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
5	beta	beta	PROPN	NNP	Number=Sing	_	_	_	_
6	1	1	NUM	CD	NumType=Card	_	_	_	_
7	did	do	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
8	not	not	PART	RB	_	_	_	_	_
9	induce	induce	VERB	VB	VerbForm=Inf	_	_	_	_
10	dephosphorylation	dephosphorylation	NOUN	NN	Number=Sing	_	_	_	_
11	of	of	ADP	IN	_	_	_	_	_
12	pRb	pRb	PROPN	NNP	Number=Sing	_	_	_	_
13	in	in	ADP	IN	_	_	_	_	_
14	EBV	EBV	PROPN	NNP	Number=Sing	_	_	_	_
15	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
16	or	or	CCONJ	CC	_	_	_	_	_
17	LMP	Lmp	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
18	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
19	1	1	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
20	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
21	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
22	positive	positive	ADJ	JJ	Degree=Pos	_	_	_	_
23	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
24	as	as	SCONJ	IN	_	_	_	_	_
25	opposed	oppose	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
26	to	to	ADP	IN	_	_	_	_	_
27	EBV	EBV	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
28	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
29	negative	negative	ADJ	JJ	Degree=Pos	_	_	_	_
30	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
31	,	,	PUNCT	,	_	_	_	_	_
32	suggesting	suggest	VERB	VBG	VerbForm=Ger	_	_	_	_
33	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
34	dichotomy	dichotomy	NOUN	NN	Number=Sing	_	_	_	_
35	in	in	ADP	IN	_	_	_	_	_
36	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
37	TGF	Tgf	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
38	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
39	beta	beta	NOUN	NN	Number=Sing	_	_	_	_
40	1	1	NUM	CD	NumType=Card	_	_	_	_
41	signaling	signal	NOUN	NN	Number=Sing	_	_	_	_
42	pathway	pathway	NOUN	NN	Number=Sing	_	_	_	_
43	leading	lead	VERB	VBG	VerbForm=Ger	_	_	_	_
44	to	to	ADP	IN	_	_	_	_	_
45	separable	separable	ADJ	JJ	Degree=Pos	_	_	_	_
46	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
47	regulatory	regulatory	NOUN	NN	Number=Sing	_	_	_	_
48	and	and	CCONJ	CC	_	_	_	_	_
49	growth	growth	NOUN	NN	Number=Sing	_	_	_	_
50	inhibitory	inhibitory	NOUN	NN	Number=Sing	_	_	_	_
51	responses	response	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
52	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3380
# text = Furthermore, LMP-1 was found to induce the expression of cyclin D2; normal B cells or EBV-negative Burkitt's lymphoma cells do not express D-type cyclins.
1	Furthermore	furthermore	ADV	RB	_	_	_	_	SpaceAfter=No
2	,	,	PUNCT	,	_	_	_	_	_
3	LMP	LMP	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
4	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
5	1	1	NUM	CD	NumType=Card	_	_	_	_
6	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
7	found	find	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
8	to	to	PART	TO	_	_	_	_	_
9	induce	induce	VERB	VB	VerbForm=Inf	_	_	_	_
10	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
11	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
12	of	of	ADP	IN	_	_	_	_	_
13	cyclin	cyclin	NOUN	NN	Number=Sing	_	_	_	_
14	D2	d2	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
15	;	;	PUNCT	,	_	_	_	_	_
16	normal	normal	ADJ	JJ	Degree=Pos	_	_	_	_
17	B	b	ADJ	JJ	Degree=Pos	_	_	_	_
18	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
19	or	or	CCONJ	CC	_	_	_	_	_
20	EBV	EBV	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
21	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
22	negative	negative	ADJ	JJ	Degree=Pos	_	_	_	_
23	Burkitt	Burkitt	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
24	's	's	PART	POS	_	_	_	_	_
25	lymphoma	lymphoma	NOUN	NN	Number=Sing	_	_	_	_
26	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
27	do	do	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
28	not	not	PART	RB	_	_	_	_	_
29	express	express	VERB	VB	VerbForm=Inf	_	_	_	_
30	D-	D-	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
31	type	type	NOUN	NN	Number=Sing	_	_	_	_
32	cyclins	cyclin	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
33	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3381
# text = Taken together, these data point to a potential mechanism underlying EBV-mediated B cell transformation whereby constitutive induction of key cell cycle regulators by LMP-1 can lead to pRb hyperphosphorylation and uncontrolled cell proliferation.
1	Taken	take	PROPN	NNP	Number=Sing	_	_	_	_
2	together	together	ADV	RB	_	_	_	_	SpaceAfter=No
3	,	,	PUNCT	,	_	_	_	_	_
4	these	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
5	data	data	NOUN	NN	Number=Sing	_	_	_	_
6	point	point	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
7	to	to	ADP	IN	_	_	_	_	_
8	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
9	potential	potential	NOUN	NN	Number=Sing	_	_	_	_
10	mechanism	mechanism	NOUN	NN	Number=Sing	_	_	_	_
11	underlying	underlying	VERB	VBG	VerbForm=Ger	_	_	_	_
12	EBV	EBV	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
13	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
14	mediated	mediate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
15	B	b	NOUN	NN	Number=Sing	_	_	_	_
16	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
17	transformation	transformation	NOUN	NN	Number=Sing	_	_	_	_
18	whereby	whereby	ADP	IN	_	_	_	_	_
19	constitutive	constitutive	ADJ	JJ	Degree=Pos	_	_	_	_
20	induction	induction	NOUN	NN	Number=Sing	_	_	_	_
21	of	of	ADP	IN	_	_	_	_	_
22	key	key	ADJ	JJ	Degree=Pos	_	_	_	_
23	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
24	cycle	cycle	NOUN	NN	Number=Sing	_	_	_	_
25	regulators	regulator	NOUN	NNS	Number=Plur	_	_	_	_
26	by	by	ADP	IN	_	_	_	_	_
27	LMP	LMP	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
28	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
29	1	1	NUM	CD	NumType=Card	_	_	_	_
30	can	can	AUX	MD	VerbForm=Fin	_	_	_	_
31	lead	lead	VERB	VB	VerbForm=Inf	_	_	_	_
32	to	to	PART	TO	_	_	_	_	_
33	pRb	pRb	VERB	VB	VerbForm=Inf	_	_	_	_
34	hyperphosphorylation	hyperphosphorylation	NOUN	NN	Number=Sing	_	_	_	_
35	and	and	CCONJ	CC	_	_	_	_	_
36	uncontrolled	uncontroll	ADJ	JJ	Degree=Pos	_	_	_	_
37	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
38	proliferation	proliferation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
39	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 3382
# text = Document 003003457 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	003003457	003003457	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 3383
# text = Cellular and molecular mechanisms of IFN-gamma production induced by IL-2 and IL-12 in a human NK cell line.
1	Cellular	cellular	ADJ	JJ	Degree=Pos	_	_	_	_
2	and	and	CCONJ	CC	_	_	_	_	_
3	molecular	molecular	ADJ	JJ	Degree=Pos	_	_	_	_
4	mechanisms	mechanism	NOUN	NNS	Number=Plur	_	_	_	_
5	of	of	ADP	IN	_	_	_	_	_
6	IFN	IFN	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
7	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
8	gamma	gamma	NOUN	NN	Number=Sing	_	_	_	_
9	production	production	NOUN	NN	Number=Sing	_	_	_	_
10	induced	induce	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
11	by	by	ADP	IN	_	_	_	_	_
12	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
13	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
14	2	2	NUM	CD	NumType=Card	_	_	_	_
15	and	and	CCONJ	CC	_	_	_	_	_
16	IL	Il	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
17	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
18	12	12	NUM	CD	NumType=Card	_	_	_	_
19	in	in	ADP	IN	_	_	_	_	_
20	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
21	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
22	NK	NK	PROPN	NNP	Number=Sing	_	_	_	_
23	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
24	line	line	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
25	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 3384
# text = Interferon-gamma (IFN-gamma) is an important immunoregulatory protein produced predominantly by T cells and large granular lymphocytes (LGL) in response to different extracellular signals.
1	Interferon	Interferon	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
2	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
3	gamma	gamma	NOUN	NN	Number=Sing	_	_	_	_
4	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
5	IFN	Ifn	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
6	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
7	gamma	gamma	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
8	)	)	PUNCT	-RRB-	_	_	_	_	_
9	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
10	an	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
11	important	important	ADJ	JJ	Degree=Pos	_	_	_	_
12	immunoregulatory	immunoregulatory	ADJ	JJ	Degree=Pos	_	_	_	_
13	protein	protein	NOUN	NN	Number=Sing	_	_	_	_
14	produced	produce	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
15	predominantly	predominantly	ADV	RB	_	_	_	_	_
16	by	by	ADP	IN	_	_	_	_	_
17	T	T	PROPN	NNP	Number=Sing	_	_	_	_
18	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
19	and	and	CCONJ	CC	_	_	_	_	_
20	large	large	ADJ	JJ	Degree=Pos	_	_	_	_
21	granular	granular	ADJ	JJ	Degree=Pos	_	_	_	_
22	lymphocytes	lymphocyte	NOUN	NNS	Number=Plur	_	_	_	_
23	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
24	LGL	LGL	INTJ	UH	_	_	_	_	SpaceAfter=No
25	)	)	PUNCT	-RRB-	_	_	_	_	_
26	in	in	ADP	IN	_	_	_	_	_
27	response	response	NOUN	NN	Number=Sing	_	_	_	_
28	to	to	ADP	IN	_	_	_	_	_
29	different	different	ADJ	JJ	Degree=Pos	_	_	_	_
30	extracellular	extracellular	ADJ	JJ	Degree=Pos	_	_	_	_
31	signals	signal	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
32	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3385
# text = In particular, two interleukins (ILs), IL-2 and IL-12, have been shown to be potent inducers of IFN-gamma gene expression in both T cells and LGL.
1	In	in	ADP	IN	_	_	_	_	_
2	particular	particular	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
3	,	,	PUNCT	,	_	_	_	_	_
4	two	two	NUM	CD	NumType=Card	_	_	_	_
5	interleukins	interleukin	NOUN	NNS	Number=Plur	_	_	_	_
6	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
7	ILs	ILs	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
8	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
9	,	,	PUNCT	,	_	_	_	_	_
10	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
11	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
12	2	2	NUM	CD	NumType=Card	_	_	_	_
13	and	and	CCONJ	CC	_	_	_	_	_
14	IL	Il	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
15	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
16	12	12	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
17	,	,	PUNCT	,	_	_	_	_	_
18	have	have	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
19	been	be	AUX	VBN	Tense=Past|VerbForm=Part	_	_	_	_
20	shown	show	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
21	to	to	PART	TO	_	_	_	_	_
22	be	be	AUX	VB	VerbForm=Inf	_	_	_	_
23	potent	potent	ADJ	JJ	Degree=Pos	_	_	_	_
24	inducers	inducer	NOUN	NNS	Number=Plur	_	_	_	_
25	of	of	ADP	IN	_	_	_	_	_
26	IFN	IFN	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
27	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
28	gamma	gamma	NOUN	NN	Number=Sing	_	_	_	_
29	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
30	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
31	in	in	ADP	IN	_	_	_	_	_
32	both	both	DET	DT	_	_	_	_	_
33	T	t	PROPN	NNP	Number=Sing	_	_	_	_
34	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
35	and	and	CCONJ	CC	_	_	_	_	_
36	LGL	LGL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
37	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3386
# text = Although it has been reported that there are some T cell lines that produce IFN-gamma in response to IL-2 and IL-12 stimulation, there has as yet been no report of a natural killer (NK) cell line that responds in a similar manner.
1	Although	although	SCONJ	IN	_	_	_	_	_
2	it	it	PRON	PRP	Case=Nom|Gender=Neut|Number=Sing|Person=3|PronType=Prs	_	_	_	_
3	has	have	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
4	been	be	AUX	VBN	Tense=Past|VerbForm=Part	_	_	_	_
5	reported	report	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
6	that	that	SCONJ	IN	_	_	_	_	_
7	there	there	PRON	EX	_	_	_	_	_
8	are	be	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
9	some	some	DET	DT	_	_	_	_	_
10	T	t	PROPN	NNP	Number=Sing	_	_	_	_
11	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
12	lines	line	NOUN	NNS	Number=Plur	_	_	_	_
13	that	that	PRON	WDT	PronType=Rel	_	_	_	_
14	produce	produce	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
15	IFN	Ifn	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
16	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
17	gamma	gamma	NOUN	NN	Number=Sing	_	_	_	_
18	in	in	ADP	IN	_	_	_	_	_
19	response	response	NOUN	NN	Number=Sing	_	_	_	_
20	to	to	ADP	IN	_	_	_	_	_
21	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
22	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
23	2	2	NUM	CD	NumType=Card	_	_	_	_
24	and	and	CCONJ	CC	_	_	_	_	_
25	IL	Il	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
26	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
27	12	12	NUM	CD	NumType=Card	_	_	_	_
28	stimulation	stimulation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
29	,	,	PUNCT	,	_	_	_	_	_
30	there	there	PRON	EX	_	_	_	_	_
31	has	have	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
32	as	as	SCONJ	IN	_	_	_	_	_
33	yet	yet	CCONJ	CC	_	_	_	_	_
34	been	be	AUX	VBN	Tense=Past|VerbForm=Part	_	_	_	_
35	no	no	DET	DT	_	_	_	_	_
36	report	report	NOUN	NN	Number=Sing	_	_	_	_
37	of	of	ADP	IN	_	_	_	_	_
38	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
39	natural	natural	ADJ	JJ	Degree=Pos	_	_	_	_
40	killer	killer	NOUN	NN	Number=Sing	_	_	_	_
41	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
42	NK	NK	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
43	)	)	PUNCT	-RRB-	_	_	_	_	_
44	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
45	line	line	NOUN	NN	Number=Sing	_	_	_	_
46	that	that	PRON	WDT	PronType=Rel	_	_	_	_
47	responds	respond	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
48	in	in	ADP	IN	_	_	_	_	_
49	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
50	similar	similar	ADJ	JJ	Degree=Pos	_	_	_	_
51	manner	manner	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
52	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3387
# text = In this report we present evidence that the cell line NK3.3 derived from human NK cells, responds to both IL-2 and IL-12, as measured by increases in IFN-gamma and granulocyte-macrophage colony-stimulating factor (GM-CSF) cytoplasmic mRNA and protein expression.
1	In	in	ADP	IN	_	_	_	_	_
2	this	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
3	report	report	NOUN	NN	Number=Sing	_	_	_	_
4	we	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
5	present	present	ADJ	JJ	Degree=Pos	_	_	_	_
6	evidence	evidence	NOUN	NN	Number=Sing	_	_	_	_
7	that	that	SCONJ	IN	_	_	_	_	_
8	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
9	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
10	line	line	NOUN	NN	Number=Sing	_	_	_	_
11	NK3.3	NK3.3	NUM	CD	NumType=Card	_	_	_	_
12	derived	derive	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
13	from	from	ADP	IN	_	_	_	_	_
14	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
15	NK	NK	PROPN	NNP	Number=Sing	_	_	_	_
16	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
17	,	,	PUNCT	,	_	_	_	_	_
18	responds	respond	NOUN	NNS	Number=Plur	_	_	_	_
19	to	to	ADP	IN	_	_	_	_	_
20	both	both	CCONJ	CC	_	_	_	_	_
21	IL	Il	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
22	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
23	2	2	NUM	CD	NumType=Card	_	_	_	_
24	and	and	CCONJ	CC	_	_	_	_	_
25	IL	Il	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
26	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
27	12	12	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
28	,	,	PUNCT	,	_	_	_	_	_
29	as	as	SCONJ	IN	_	_	_	_	_
30	measured	measure	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
31	by	by	ADP	IN	_	_	_	_	_
32	increases	increase	NOUN	NNS	Number=Plur	_	_	_	_
33	in	in	ADP	IN	_	_	_	_	_
34	IFN	IFN	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
35	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
36	gamma	gamma	NOUN	NN	Number=Sing	_	_	_	_
37	and	and	CCONJ	CC	_	_	_	_	_
38	granulocyte	granulocyte	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
39	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
40	macrophage	macrophage	NOUN	NN	Number=Sing	_	_	_	_
41	colony	colony	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
42	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
43	stimulating	stimulating	VERB	VBG	VerbForm=Ger	_	_	_	_
44	factor	factor	NOUN	NN	Number=Sing	_	_	_	_
45	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
46	GM	GM	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
47	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
48	CSF	CSF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
49	)	)	PUNCT	-RRB-	_	_	_	_	_
50	cytoplasmic	cytoplasmic	ADJ	JJ	Degree=Pos	_	_	_	_
51	mRNA	mRNa	NOUN	NN	Number=Sing	_	_	_	_
52	and	and	CCONJ	CC	_	_	_	_	_
53	protein	protein	NOUN	NN	Number=Sing	_	_	_	_
54	expression	expression	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
55	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3388
# text = In addition, when used together IL-2 and IL-12 synergized in the induction of IFN-gamma and GM-CSF and this synergy was attributed to an increased accumulation and stability of the IFN-gamma and GM-CSF mRNAs.
1	In	in	ADP	IN	_	_	_	_	_
2	addition	addition	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
3	,	,	PUNCT	,	_	_	_	_	_
4	when	when	ADV	WRB	PronType=Int	_	_	_	_
5	used	use	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
6	together	together	ADV	RB	_	_	_	_	_
7	IL	IL	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
8	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
9	2	2	NUM	CD	NumType=Card	_	_	_	_
10	and	and	CCONJ	CC	_	_	_	_	_
11	IL	Il	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
12	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
13	12	12	NUM	CD	NumType=Card	_	_	_	_
14	synergized	synergize	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
15	in	in	ADP	IN	_	_	_	_	_
16	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
17	induction	induction	NOUN	NN	Number=Sing	_	_	_	_
18	of	of	ADP	IN	_	_	_	_	_
19	IFN	IFN	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
20	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
21	gamma	gamma	PROPN	NNP	Number=Sing	_	_	_	_
22	and	and	CCONJ	CC	_	_	_	_	_
23	GM	GM	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
24	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
25	CSF	CSF	PROPN	NNP	Number=Sing	_	_	_	_
26	and	and	CCONJ	CC	_	_	_	_	_
27	this	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
28	synergy	synergy	NOUN	NN	Number=Sing	_	_	_	_
29	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
30	attributed	attribute	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
31	to	to	ADP	IN	_	_	_	_	_
32	an	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
33	increased	increase	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
34	accumulation	accumulation	NOUN	NN	Number=Sing	_	_	_	_
35	and	and	CCONJ	CC	_	_	_	_	_
36	stability	stability	NOUN	NN	Number=Sing	_	_	_	_
37	of	of	ADP	IN	_	_	_	_	_
38	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
39	IFN	IFN	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
40	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
41	gamma	gamma	PROPN	NNP	Number=Sing	_	_	_	_
42	and	and	CCONJ	CC	_	_	_	_	_
43	GM	GM	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
44	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
45	CSF	CSF	PROPN	NNP	Number=Sing	_	_	_	_
46	mRNAs	mRNA	PROPN	NNPS	Number=Plur	_	_	_	SpaceAfter=No
47	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3389
# text = To investigate the signaling pathways involved in the gene induction, five inhibitors, cyclosporin A (CsA), transforming growth factor-beta, cycloheximide, genistein, and staurosporine A, were used in analyzing the effects of IL-2 and IL-12 on NK3.3 cells.
1	To	to	PART	TO	_	_	_	_	_
2	investigate	investigate	VERB	VB	VerbForm=Inf	_	_	_	_
3	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
4	signaling	signaling	NOUN	NN	Number=Sing	_	_	_	_
5	pathways	pathway	NOUN	NNS	Number=Plur	_	_	_	_
6	involved	involved	ADJ	JJ	Degree=Pos	_	_	_	_
7	in	in	ADP	IN	_	_	_	_	_
8	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
9	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
10	induction	induction	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
11	,	,	PUNCT	,	_	_	_	_	_
12	five	five	NUM	CD	NumType=Card	_	_	_	_
13	inhibitors	inhibitor	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
14	,	,	PUNCT	,	_	_	_	_	_
15	cyclosporin	cyclosporin	NOUN	NN	Number=Sing	_	_	_	_
16	A	a	NOUN	NN	Number=Sing	_	_	_	_
17	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
18	CsA	csa	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
19	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
20	,	,	PUNCT	,	_	_	_	_	_
21	transforming	transforming	VERB	VBG	VerbForm=Ger	_	_	_	_
22	growth	growth	NOUN	NN	Number=Sing	_	_	_	_
23	factor	factor	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
24	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
25	beta	beta	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
26	,	,	PUNCT	,	_	_	_	_	_
27	cycloheximide	cycloheximide	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
28	,	,	PUNCT	,	_	_	_	_	_
29	genistein	genistein	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
30	,	,	PUNCT	,	_	_	_	_	_
31	and	and	CCONJ	CC	_	_	_	_	_
32	staurosporine	staurosporine	NOUN	NN	Number=Sing	_	_	_	_
33	A	a	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
34	,	,	PUNCT	,	_	_	_	_	_
35	were	be	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
36	used	use	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
37	in	in	SCONJ	IN	_	_	_	_	_
38	analyzing	analyze	VERB	VBG	VerbForm=Ger	_	_	_	_
39	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
40	effects	effect	NOUN	NNS	Number=Plur	_	_	_	_
41	of	of	ADP	IN	_	_	_	_	_
42	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
43	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
44	2	2	NUM	CD	NumType=Card	_	_	_	_
45	and	and	CCONJ	CC	_	_	_	_	_
46	IL	Il	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
47	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
48	12	12	NUM	CD	NumType=Card	_	_	_	_
49	on	on	ADP	IN	_	_	_	_	_
50	NK3.3	NK3.3	NUM	CD	NumType=Card	_	_	_	_
51	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
52	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3390
# text = The results suggest that activation of protein kinase C, but not new protein synthesis, is required for IL-2 induction of IFN-gamma and GM-CSF cytoplasmic mRNA.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	results	result	NOUN	NNS	Number=Plur	_	_	_	_
3	suggest	suggest	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
4	that	that	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
5	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
6	of	of	ADP	IN	_	_	_	_	_
7	protein	protein	NOUN	NN	Number=Sing	_	_	_	_
8	kinase	kinase	NOUN	NN	Number=Sing	_	_	_	_
9	C	C	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
10	,	,	PUNCT	,	_	_	_	_	_
11	but	but	CCONJ	CC	_	_	_	_	_
12	not	not	ADV	RB	_	_	_	_	_
13	new	new	ADJ	JJ	Degree=Pos	_	_	_	_
14	protein	protein	NOUN	NN	Number=Sing	_	_	_	_
15	synthesis	synthesis	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
16	,	,	PUNCT	,	_	_	_	_	_
17	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
18	required	require	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
19	for	for	ADP	IN	_	_	_	_	_
20	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
21	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
22	2	2	NUM	CD	NumType=Card	_	_	_	_
23	induction	induction	NOUN	NN	Number=Sing	_	_	_	_
24	of	of	ADP	IN	_	_	_	_	_
25	IFN	IFN	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
26	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
27	gamma	gamma	PROPN	NNP	Number=Sing	_	_	_	_
28	and	and	CCONJ	CC	_	_	_	_	_
29	GM	GM	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
30	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
31	CSF	CSF	PROPN	NNP	Number=Sing	_	_	_	_
32	cytoplasmic	cytoplasmic	PROPN	NNP	Number=Sing	_	_	_	_
33	mRNA	mRNa	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
34	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3391
# text = In contrast, IL-12 induction of IFN-gamma cytoplasmic mRNA appears to only partially depend on activation of protein kinase C. Furthermore, both transforming growth factor-beta and genistein, a tyrosine kinase inhibitor, could suppress IL-2 and IL-12 signaling but CsA was generally inactive.
1	In	in	ADP	IN	_	_	_	_	_
2	contrast	contrast	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
3	,	,	PUNCT	,	_	_	_	_	_
4	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
5	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
6	12	12	NUM	CD	NumType=Card	_	_	_	_
7	induction	induction	NOUN	NN	Number=Sing	_	_	_	_
8	of	of	ADP	IN	_	_	_	_	_
9	IFN	IFN	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
10	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
11	gamma	gamma	X	FW	Foreign=Yes	_	_	_	_
12	cytoplasmic	cytoplasmic	ADJ	JJ	Degree=Pos	_	_	_	_
13	mRNA	mRNa	NOUN	NN	Number=Sing	_	_	_	_
14	appears	appear	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
15	to	to	PART	TO	_	_	_	_	_
16	only	only	ADV	RB	_	_	_	_	_
17	partially	partially	ADV	RB	_	_	_	_	_
18	depend	depend	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
19	on	on	ADP	IN	_	_	_	_	_
20	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
21	of	of	ADP	IN	_	_	_	_	_
22	protein	protein	NOUN	NN	Number=Sing	_	_	_	_
23	kinase	kinase	NOUN	NN	Number=Sing	_	_	_	_
24	C.	c.	PROPN	NNP	Number=Sing	_	_	_	_
25	Furthermore	Furthermore	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
26	,	,	PUNCT	,	_	_	_	_	_
27	both	both	CCONJ	CC	_	_	_	_	_
28	transforming	transform	VERB	VBG	VerbForm=Ger	_	_	_	_
29	growth	growth	NOUN	NN	Number=Sing	_	_	_	_
30	factor	factor	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
31	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
32	beta	beta	NOUN	NN	Number=Sing	_	_	_	_
33	and	and	CCONJ	CC	_	_	_	_	_
34	genistein	genistein	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
35	,	,	PUNCT	,	_	_	_	_	_
36	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
37	tyrosine	tyrosine	NOUN	NN	Number=Sing	_	_	_	_
38	kinase	kinase	NOUN	NN	Number=Sing	_	_	_	_
39	inhibitor	inhibitor	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
40	,	,	PUNCT	,	_	_	_	_	_
41	could	could	AUX	MD	VerbForm=Fin	_	_	_	_
42	suppress	suppress	VERB	VB	VerbForm=Inf	_	_	_	_
43	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
44	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
45	2	2	NUM	CD	NumType=Card	_	_	_	_
46	and	and	CCONJ	CC	_	_	_	_	_
47	IL	Il	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
48	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
49	12	12	NUM	CD	NumType=Card	_	_	_	_
50	signaling	signaling	NOUN	NN	Number=Sing	_	_	_	_
51	but	but	CCONJ	CC	_	_	_	_	_
52	CsA	csa	PROPN	NNP	Number=Sing	_	_	_	_
53	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
54	generally	generally	ADV	RB	_	_	_	_	_
55	inactive	inactive	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
56	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3392
# text = It also was observed that suppression of cytokine gene expression by these agents was independent of the inhibition of proliferation.
1	It	it	PRON	PRP	Case=Nom|Gender=Neut|Number=Sing|Person=3|PronType=Prs	_	_	_	_
2	also	also	ADV	RB	_	_	_	_	_
3	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
4	observed	observe	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
5	that	that	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
6	suppression	suppression	NOUN	NN	Number=Sing	_	_	_	_
7	of	of	ADP	IN	_	_	_	_	_
8	cytokine	cytokine	NOUN	NN	Number=Sing	_	_	_	_
9	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
10	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
11	by	by	ADP	IN	_	_	_	_	_
12	these	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
13	agents	agent	NOUN	NNS	Number=Plur	_	_	_	_
14	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
15	independent	independent	ADJ	JJ	Degree=Pos	_	_	_	_
16	of	of	ADP	IN	_	_	_	_	_
17	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
18	inhibition	inhibition	NOUN	NN	Number=Sing	_	_	_	_
19	of	of	ADP	IN	_	_	_	_	_
20	proliferation	proliferation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
21	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3393
# text = In addition, IL-2 but not IL-12 induced nuclear factors NF-kappa B and AP1, and regulation of the nuclear levels of these two DNA binding protein complexes is correlated with IFN-gamma and GM-CSF gene expression.
1	In	in	ADP	IN	_	_	_	_	_
2	addition	addition	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
3	,	,	PUNCT	,	_	_	_	_	_
4	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
5	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
6	2	2	NUM	CD	NumType=Card	_	_	_	_
7	but	but	CCONJ	CC	_	_	_	_	_
8	not	not	PART	RB	_	_	_	_	_
9	IL	Il	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
10	-	-	SYM	SYM	_	_	_	_	SpaceAfter=No
11	12	12	NUM	CD	NumType=Card	_	_	_	_
12	induced	induce	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
13	nuclear	nuclear	ADJ	JJ	Degree=Pos	_	_	_	_
14	factors	factor	NOUN	NNS	Number=Plur	_	_	_	_
15	NF	Nf	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
16	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
17	kappa	kappa	PROPN	NNP	Number=Sing	_	_	_	_
18	B	b	PROPN	NNP	Number=Sing	_	_	_	_
19	and	and	CCONJ	CC	_	_	_	_	_
20	AP1	Ap1	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
21	,	,	PUNCT	,	_	_	_	_	_
22	and	and	CCONJ	CC	_	_	_	_	_
23	regulation	regulation	NOUN	NN	Number=Sing	_	_	_	_
24	of	of	ADP	IN	_	_	_	_	_
25	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
26	nuclear	nuclear	ADJ	JJ	Degree=Pos	_	_	_	_
27	levels	level	NOUN	NNS	Number=Plur	_	_	_	_
28	of	of	ADP	IN	_	_	_	_	_
29	these	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
30	two	two	NUM	CD	NumType=Card	_	_	_	_
31	DNA	dna	NOUN	NN	Number=Sing	_	_	_	_
32	binding	binde	VERB	VBG	VerbForm=Ger	_	_	_	_
33	protein	protein	NOUN	NN	Number=Sing	_	_	_	_
34	complexes	complex	NOUN	NNS	Number=Plur	_	_	_	_
35	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
36	correlated	correlate	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
37	with	with	ADP	IN	_	_	_	_	_
38	IFN	IFN	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
39	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
40	gamma	gamma	PROPN	NNP	Number=Sing	_	_	_	_
41	and	and	CCONJ	CC	_	_	_	_	_
42	GM	GM	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
43	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
44	CSF	CSF	PROPN	NNP	Number=Sing	_	_	_	_
45	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
46	expression	expression	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
47	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3394
# text = These data indicate that IL-2 and IL-12 may have distinct signaling pathways leading to the induction of IFN-gamma and GM-CSF gene expression, and that the NK3.3 cell line may serve as a novel model for dissecting the biochemical and molecular events involved in these pathways.
1	These	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
2	data	data	NOUN	NN	Number=Sing	_	_	_	_
3	indicate	indicate	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
4	that	that	SCONJ	IN	_	_	_	_	_
5	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
6	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
7	2	2	NUM	CD	NumType=Card	_	_	_	_
8	and	and	CCONJ	CC	_	_	_	_	_
9	IL	Il	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
10	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
11	12	12	NUM	CD	NumType=Card	_	_	_	_
12	may	may	AUX	MD	VerbForm=Fin	_	_	_	_
13	have	have	VERB	VB	VerbForm=Inf	_	_	_	_
14	distinct	distinct	ADJ	JJ	Degree=Pos	_	_	_	_
15	signaling	signaling	NOUN	NN	Number=Sing	_	_	_	_
16	pathways	pathway	NOUN	NNS	Number=Plur	_	_	_	_
17	leading	lead	VERB	VBG	VerbForm=Ger	_	_	_	_
18	to	to	ADP	IN	_	_	_	_	_
19	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
20	induction	induction	NOUN	NN	Number=Sing	_	_	_	_
21	of	of	ADP	IN	_	_	_	_	_
22	IFN	IFN	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
23	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
24	gamma	gamma	PROPN	NNP	Number=Sing	_	_	_	_
25	and	and	CCONJ	CC	_	_	_	_	_
26	GM	GM	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
27	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
28	CSF	CSF	PROPN	NNP	Number=Sing	_	_	_	_
29	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
30	expression	expression	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
31	,	,	PUNCT	,	_	_	_	_	_
32	and	and	CCONJ	CC	_	_	_	_	_
33	that	that	SCONJ	IN	_	_	_	_	_
34	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
35	NK3.3	NK3.3	NOUN	NN	Number=Sing	_	_	_	_
36	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
37	line	line	NOUN	NN	Number=Sing	_	_	_	_
38	may	may	AUX	MD	VerbForm=Fin	_	_	_	_
39	serve	serve	VERB	VB	VerbForm=Inf	_	_	_	_
40	as	as	ADP	IN	_	_	_	_	_
41	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
42	novel	novel	NOUN	NN	Number=Sing	_	_	_	_
43	model	model	NOUN	NN	Number=Sing	_	_	_	_
44	for	for	SCONJ	IN	_	_	_	_	_
45	dissecting	dissect	VERB	VBG	VerbForm=Ger	_	_	_	_
46	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
47	biochemical	biochemical	ADJ	JJ	Degree=Pos	_	_	_	_
48	and	and	CCONJ	CC	_	_	_	_	_
49	molecular	molecular	ADJ	JJ	Degree=Pos	_	_	_	_
50	events	event	NOUN	NNS	Number=Plur	_	_	_	_
51	involved	involved	ADJ	JJ	Degree=Pos	_	_	_	_
52	in	in	ADP	IN	_	_	_	_	_
53	these	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
54	pathways	pathway	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
55	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 3395
# text = Document 003003458 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	003003458	003003458	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 3396
# text = Jeg-3 human choriocarcinoma-induced immunosuppression: downregulation of interleukin-2, interleukin-2 receptor alpha-chain, and its Jak/Stat signaling pathway.
1	Jeg	Jeg	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
2	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
3	3	3	NUM	CD	NumType=Card	_	_	_	_
4	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
5	choriocarcinoma	choriocarcinoma	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
6	-induced	-induce	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
7	immunosuppression	immunosuppression	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
8	:	:	PUNCT	:	_	_	_	_	_
9	downregulation	downregulation	NOUN	NN	Number=Sing	_	_	_	_
10	of	of	ADP	IN	_	_	_	_	_
11	interleukin	interleukin	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
12	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
13	2	2	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
14	,	,	PUNCT	,	_	_	_	_	_
15	interleukin	interleukin	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
16	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
17	2	2	NUM	CD	NumType=Card	_	_	_	_
18	receptor	receptor	NOUN	NN	Number=Sing	_	_	_	_
19	alpha-	alpha-	SYM	SYM	_	_	_	_	SpaceAfter=No
20	chain	chain	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
21	,	,	PUNCT	,	_	_	_	_	_
22	and	and	CCONJ	CC	_	_	_	_	_
23	its	its	PRON	PRP$	Gender=Neut|Number=Sing|Person=3|Poss=Yes|PronType=Prs	_	_	_	_
24	Jak	Jak	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
25	/	/	PUNCT	,	_	_	_	_	SpaceAfter=No
26	Stat	Stat	PROPN	NNP	Number=Sing	_	_	_	_
27	signaling	signale	VERB	VBG	VerbForm=Ger	_	_	_	_
28	pathway	pathway	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
29	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 3397
# text = PROBLEM: The mechanisms of the immunosuppressive and immunosuppression-inducing capacities of Jeg-3 human choriocarcinoma cell line supernatants (HCSs) are not yet completely understood.
1	PROBLEM	problem	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
2	:	:	PUNCT	:	_	_	_	_	_
3	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
4	mechanisms	mechanism	NOUN	NNS	Number=Plur	_	_	_	_
5	of	of	ADP	IN	_	_	_	_	_
6	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
7	immunosuppressive	immunosuppressive	ADJ	JJ	Degree=Pos	_	_	_	_
8	and	and	CCONJ	CC	_	_	_	_	_
9	immunosuppression	immunosuppression	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
10	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
11	inducing	induce	VERB	VBG	VerbForm=Ger	_	_	_	_
12	capacities	capacitie	NOUN	NNS	Number=Plur	_	_	_	_
13	of	of	ADP	IN	_	_	_	_	_
14	Jeg	Jeg	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
15	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
16	3	3	NUM	CD	NumType=Card	_	_	_	_
17	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
18	choriocarcinoma	choriocarcinoma	NOUN	NN	Number=Sing	_	_	_	_
19	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
20	line	line	NOUN	NN	Number=Sing	_	_	_	_
21	supernatants	supernatant	NOUN	NNS	Number=Plur	_	_	_	_
22	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
23	HCSs	HCS	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
24	)	)	PUNCT	-RRB-	_	_	_	_	_
25	are	be	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
26	not	not	PART	RB	_	_	_	_	_
27	yet	yet	ADV	RB	_	_	_	_	_
28	completely	completely	ADV	RB	_	_	_	_	_
29	understood	understand	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	SpaceAfter=No
30	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3398
# text = The influence on interleukin (IL)-2, IL-4 and interferon (IFN)-gamma production; IL-2 receptor (IL-2R) alpha-, beta-, and gamma-chain; and the signaling pathway molecules Janus kinase (Jak)1, Jak3, signal transducers and activators of transcription (Stat)1, Stat3, and Stat5 should be investigated.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	influence	influence	NOUN	NN	Number=Sing	_	_	_	_
3	on	on	ADP	IN	_	_	_	_	_
4	interleukin	interleukin	NOUN	NN	Number=Sing	_	_	_	_
5	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
6	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
7	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
8	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
9	2	2	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
10	,	,	PUNCT	,	_	_	_	_	_
11	IL	IL	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
12	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
13	4	4	NUM	CD	NumType=Card	_	_	_	_
14	and	and	CCONJ	CC	_	_	_	_	_
15	interferon	interferon	NOUN	NN	Number=Sing	_	_	_	_
16	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
17	IFN	IFN	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
18	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
19	-	-	PUNCT	:	_	_	_	_	SpaceAfter=No
20	gamma	gamma	NOUN	NN	Number=Sing	_	_	_	_
21	production	production	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
22	;	;	PUNCT	,	_	_	_	_	_
23	IL	IL	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
24	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
25	2	2	NUM	CD	NumType=Card	_	_	_	_
26	receptor	receptor	NOUN	NN	Number=Sing	_	_	_	_
27	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
28	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
29	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
30	2R	2R	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
31	)	)	PUNCT	-RRB-	_	_	_	_	_
32	alpha	alpha	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
33	-	-	PUNCT	:	_	_	_	_	SpaceAfter=No
34	,	,	PUNCT	,	_	_	_	_	_
35	beta	beta	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
36	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
37	,	,	PUNCT	,	_	_	_	_	_
38	and	and	CCONJ	CC	_	_	_	_	_
39	gamma	gamma	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
40	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
41	chain	chain	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
42	;	;	PUNCT	,	_	_	_	_	_
43	and	and	CCONJ	CC	_	_	_	_	_
44	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
45	signaling	signal	VERB	VBG	VerbForm=Ger	_	_	_	_
46	pathway	pathway	NOUN	NN	Number=Sing	_	_	_	_
47	molecules	molecule	NOUN	NNS	Number=Plur	_	_	_	_
48	Janus	Janus	CCONJ	CC	_	_	_	_	_
49	kinase	kinase	NOUN	NN	Number=Sing	_	_	_	_
50	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
51	Jak	Jak	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
52	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
53	1	1	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
54	,	,	PUNCT	,	_	_	_	_	_
55	Jak3	Jak3	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
56	,	,	PUNCT	,	_	_	_	_	_
57	signal	signal	NOUN	NN	Number=Sing	_	_	_	_
58	transducers	transducer	NOUN	NNS	Number=Plur	_	_	_	_
59	and	and	CCONJ	CC	_	_	_	_	_
60	activators	activator	NOUN	NNS	Number=Plur	_	_	_	_
61	of	of	ADP	IN	_	_	_	_	_
62	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
63	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
64	Stat	Stat	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
65	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
66	1	1	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
67	,	,	PUNCT	,	_	_	_	_	_
68	Stat3	Stat3	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
69	,	,	PUNCT	,	_	_	_	_	_
70	and	and	CCONJ	CC	_	_	_	_	_
71	Stat5	Stat5	PROPN	NNP	Number=Sing	_	_	_	_
72	should	should	AUX	MD	VerbForm=Fin	_	_	_	_
73	be	be	AUX	VB	VerbForm=Inf	_	_	_	_
74	investigated	investigate	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	SpaceAfter=No
75	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3399
# text = METHOD OF STUDY:
1	METHOD	method	NOUN	NN	Number=Sing	_	_	_	_
2	OF	of	ADP	IN	_	_	_	_	_
3	STUDY	study	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
4	:	:	PUNCT	:	_	_	_	_	_

# sent_id = 3400
# text = For assessment of IL production, whole peripheral venous blood from healthy donors was stimulated with phorbol-myristate-acetate and ionomycine.
1	For	for	ADP	IN	_	_	_	_	_
2	assessment	assessment	NOUN	NN	Number=Sing	_	_	_	_
3	of	of	ADP	IN	_	_	_	_	_
4	IL	Il	PROPN	NNP	Number=Sing	_	_	_	_
5	production	production	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
6	,	,	PUNCT	,	_	_	_	_	_
7	whole	whole	ADJ	JJ	Degree=Pos	_	_	_	_
8	peripheral	peripheral	ADJ	JJ	Degree=Pos	_	_	_	_
9	venous	venous	ADJ	JJ	Degree=Pos	_	_	_	_
10	blood	blood	NOUN	NN	Number=Sing	_	_	_	_
11	from	from	ADP	IN	_	_	_	_	_
12	healthy	healthy	ADJ	JJ	Degree=Pos	_	_	_	_
13	donors	donor	NOUN	NNS	Number=Plur	_	_	_	_
14	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
15	stimulated	stimulate	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
16	with	with	ADP	IN	_	_	_	_	_
17	phorbol	phorbol	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
18	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
19	myristate	myristate	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
20	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
21	acetate	acetate	NOUN	NN	Number=Sing	_	_	_	_
22	and	and	CCONJ	CC	_	_	_	_	_
23	ionomycine	ionomycine	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
24	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3401
# text = Secretion of ILs was blocked with monensine.
1	Secretion	Secretion	NOUN	NN	Number=Sing	_	_	_	_
2	of	of	ADP	IN	_	_	_	_	_
3	ILs	ILs	PROPN	NNP	Number=Sing	_	_	_	_
4	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
5	blocked	block	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
6	with	with	ADP	IN	_	_	_	_	_
7	monensine	monensine	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
8	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3402
# text = Intracellular ILs were analyzed by flow cytometry.
1	Intracellular	Intracellular	ADJ	JJ	Degree=Pos	_	_	_	_
2	ILs	IL	NOUN	NNS	Number=Plur	_	_	_	_
3	were	be	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
4	analyzed	analyze	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
5	by	by	ADP	IN	_	_	_	_	_
6	flow	flow	NOUN	NN	Number=Sing	_	_	_	_
7	cytometry	cytometry	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
8	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3403
# text = For IL-2R and signaling pathway molecule analysis, peripheral blood lymphocytes were stimulated with phytohemagglutinin (PHA).
1	For	for	ADP	IN	_	_	_	_	_
2	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
3	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
4	2	2	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
5	R	r	NOUN	NN	Number=Sing	_	_	_	_
6	and	and	CCONJ	CC	_	_	_	_	_
7	signaling	signal	VERB	VBG	VerbForm=Ger	_	_	_	_
8	pathway	pathway	NOUN	NN	Number=Sing	_	_	_	_
9	molecule	molecule	NOUN	NN	Number=Sing	_	_	_	_
10	analysis	analysis	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
11	,	,	PUNCT	,	_	_	_	_	_
12	peripheral	peripheral	ADJ	JJ	Degree=Pos	_	_	_	_
13	blood	blood	NOUN	NN	Number=Sing	_	_	_	_
14	lymphocytes	lymphocyte	NOUN	NNS	Number=Plur	_	_	_	_
15	were	be	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
16	stimulated	stimulate	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
17	with	with	ADP	IN	_	_	_	_	_
18	phytohemagglutinin	phytohemagglutinin	NOUN	NN	Number=Sing	_	_	_	_
19	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
20	PHA	PHA	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
21	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
22	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3404
# text = IL-2R chains were measured by flow cytometry, and Jaks/Stats by sodium dodecyl sulfate polyacrylamide gel electrophoresis (SDS-PAGE) and Western blot.
1	IL	Il	INTJ	UH	_	_	_	_	SpaceAfter=No
2	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
3	2	2	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
4	R	r	ADJ	JJR	Degree=Cmp	_	_	_	_
5	chains	chain	NOUN	NNS	Number=Plur	_	_	_	_
6	were	be	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
7	measured	measure	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
8	by	by	ADP	IN	_	_	_	_	_
9	flow	flow	NOUN	NN	Number=Sing	_	_	_	_
10	cytometry	cytometry	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
11	,	,	PUNCT	,	_	_	_	_	_
12	and	and	CCONJ	CC	_	_	_	_	_
13	Jaks	Jak	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
14	/	/	PUNCT	,	_	_	_	_	SpaceAfter=No
15	Stats	Stat	PROPN	NNPS	Number=Plur	_	_	_	_
16	by	by	ADP	IN	_	_	_	_	_
17	sodium	sodium	NOUN	NN	Number=Sing	_	_	_	_
18	dodecyl	dodecyl	NOUN	NN	Number=Sing	_	_	_	_
19	sulfate	sulfate	NOUN	NN	Number=Sing	_	_	_	_
20	polyacrylamide	polyacrylamide	NOUN	NN	Number=Sing	_	_	_	_
21	gel	gel	NOUN	NN	Number=Sing	_	_	_	_
22	electrophoresis	electrophoresis	NOUN	NN	Number=Sing	_	_	_	_
23	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
24	SDS	sDs	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
25	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
26	PAGE	page	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
27	)	)	PUNCT	-RRB-	_	_	_	_	_
28	and	and	CCONJ	CC	_	_	_	_	_
29	Western	western	ADJ	JJ	Degree=Pos	_	_	_	_
30	blot	blot	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
31	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3405
# text = RESULTS: Phorbol-myristate-acetate and ionomycine strongly increase the percent-age of IL-2+ cells; an additional 50% HCSs significantly suppresses the percentage to, or below the level of unstimulated cells.
1	RESULTS	result	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
2	:	:	PUNCT	:	_	_	_	_	_
3	Phorbol	Phorbol	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
4	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
5	myristate	myristate	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
6	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
7	acetate	acetate	NOUN	NN	Number=Sing	_	_	_	_
8	and	and	CCONJ	CC	_	_	_	_	_
9	ionomycine	ionomycine	PRON	PRP	_	_	_	_	_
10	strongly	strongly	ADV	RB	_	_	_	_	_
11	increase	increase	VERB	VB	VerbForm=Inf	_	_	_	_
12	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
13	percent	percent	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
14	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
15	age	age	NOUN	NN	Number=Sing	_	_	_	_
16	of	of	ADP	IN	_	_	_	_	_
17	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
18	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
19	2	2	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
20	+	+	SYM	SYM	_	_	_	_	_
21	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
22	;	;	PUNCT	,	_	_	_	_	_
23	an	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
24	additional	additional	ADJ	JJ	Degree=Pos	_	_	_	_
25	50	50	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
26	%	%	SYM	NN	Number=Sing	_	_	_	_
27	HCSs	HCSs	PROPN	NNPS	Number=Plur	_	_	_	_
28	significantly	significantly	ADV	RB	_	_	_	_	_
29	suppresses	suppress	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
30	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
31	percentage	percentage	NOUN	NN	Number=Sing	_	_	_	_
32	to	to	ADP	IN	_	_	_	_	SpaceAfter=No
33	,	,	PUNCT	,	_	_	_	_	_
34	or	or	CCONJ	CC	_	_	_	_	_
35	below	below	ADP	IN	_	_	_	_	_
36	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
37	level	level	NOUN	NN	Number=Sing	_	_	_	_
38	of	of	ADP	IN	_	_	_	_	_
39	unstimulated	unstimulated	ADJ	JJ	Degree=Pos	_	_	_	_
40	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
41	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3406
# text = IFN-gamma production is strongly decreased by HCSs in some cases, but not in others.
1	IFN	Ifn	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
2	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
3	gamma	gamma	NOUN	NN	Number=Sing	_	_	_	_
4	production	production	NOUN	NN	Number=Sing	_	_	_	_
5	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
6	strongly	strongly	ADV	RB	_	_	_	_	_
7	decreased	decrease	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
8	by	by	ADP	IN	_	_	_	_	_
9	HCSs	HCS	NOUN	NNS	Number=Plur	_	_	_	_
10	in	in	ADP	IN	_	_	_	_	_
11	some	some	DET	DT	_	_	_	_	_
12	cases	case	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
13	,	,	PUNCT	,	_	_	_	_	_
14	but	but	CCONJ	CC	_	_	_	_	_
15	not	not	ADV	RB	_	_	_	_	_
16	in	in	ADP	IN	_	_	_	_	_
17	others	other	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
18	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3407
# text = PHA stimulates IL-2R alpha-, beta-, and gamma-chain expression and their signaling pathway molecules Jak1, Jak3, Stat1, Stat3, and Stat5.
1	PHA	PHA	PROPN	NNP	Number=Sing	_	_	_	_
2	stimulates	stimulate	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
3	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
4	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
5	2R	2R	PROPN	NNP	Number=Sing	_	_	_	_
6	alpha	alpha	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
7	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
8	,	,	PUNCT	,	_	_	_	_	_
9	beta	beta	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
10	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
11	,	,	PUNCT	,	_	_	_	_	_
12	and	and	CCONJ	CC	_	_	_	_	_
13	gamma	gamma	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
14	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
15	chain	chain	NOUN	NN	Number=Sing	_	_	_	_
16	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
17	and	and	CCONJ	CC	_	_	_	_	_
18	their	they	PRON	PRP$	Number=Plur|Person=3|Poss=Yes|PronType=Prs	_	_	_	_
19	signaling	signaling	NOUN	NN	Number=Sing	_	_	_	_
20	pathway	pathway	NOUN	NN	Number=Sing	_	_	_	_
21	molecules	molecule	NOUN	NNS	Number=Plur	_	_	_	_
22	Jak1	Jak1	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
23	,	,	PUNCT	,	_	_	_	_	_
24	Jak3	Jak3	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
25	,	,	PUNCT	,	_	_	_	_	_
26	Stat1	stat1	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
27	,	,	PUNCT	,	_	_	_	_	_
28	Stat3	Stat3	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
29	,	,	PUNCT	,	_	_	_	_	_
30	and	and	CCONJ	CC	_	_	_	_	_
31	Stat5	Stat5	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
32	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3408
# text = 50% HCS downregulates the alpha-chain and slightly upregulates the beta-chain.
1	50	50	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
2	%	%	SYM	NN	Number=Sing	_	_	_	_
3	HCS	HCS	PROPN	NNP	Number=Sing	_	_	_	_
4	downregulates	downregulate	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
5	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
6	alpha-	alpha-	SYM	NFP	_	_	_	_	SpaceAfter=No
7	chain	chain	NOUN	NN	Number=Sing	_	_	_	_
8	and	and	CCONJ	CC	_	_	_	_	_
9	slightly	slightly	ADV	RB	_	_	_	_	_
10	upregulates	upregulate	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
11	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
12	beta	beta	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
13	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
14	chain	chain	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
15	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3409
# text = Jak1, Jak3, Stat1, Stat3, and Stat5 expression is suppressed approximately to, or below the level of unstimulated cells.
1	Jak1	Jak1	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
2	,	,	PUNCT	,	_	_	_	_	_
3	Jak3	Jak3	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
4	,	,	PUNCT	,	_	_	_	_	_
5	Stat1	stat1	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
6	,	,	PUNCT	,	_	_	_	_	_
7	Stat3	Stat3	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
8	,	,	PUNCT	,	_	_	_	_	_
9	and	and	CCONJ	CC	_	_	_	_	_
10	Stat5	Stat5	NUM	CD	NumType=Card	_	_	_	_
11	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
12	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
13	suppressed	suppress	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
14	approximately	approximately	ADV	RB	_	_	_	_	_
15	to	to	ADP	IN	_	_	_	_	SpaceAfter=No
16	,	,	PUNCT	,	_	_	_	_	_
17	or	or	CCONJ	CC	_	_	_	_	_
18	below	below	ADP	IN	_	_	_	_	_
19	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
20	level	level	NOUN	NN	Number=Sing	_	_	_	_
21	of	of	ADP	IN	_	_	_	_	_
22	unstimulated	unstimulated	ADJ	JJ	Degree=Pos	_	_	_	_
23	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
24	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3410
# text = CONCLUSIONS: HCS forcefully blocks the production of IL-2; the IL-2R alpha-chain; and Jak1, Jak3, Stat1, Stat3, and Stat5 expression.
1	CONCLUSIONS	conclusion	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
2	:	:	PUNCT	:	_	_	_	_	_
3	HCS	Hc	NOUN	NNS	Number=Plur	_	_	_	_
4	forcefully	forcefully	ADV	RB	_	_	_	_	_
5	blocks	block	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
6	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
7	production	production	NOUN	NN	Number=Sing	_	_	_	_
8	of	of	ADP	IN	_	_	_	_	_
9	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
10	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
11	2	2	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
12	;	;	PUNCT	,	_	_	_	_	_
13	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
14	IL	Il	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
15	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
16	2R	2r	NOUN	NN	Number=Sing	_	_	_	_
17	alpha-	alpha-	PUNCT	:	_	_	_	_	SpaceAfter=No
18	chain	chain	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
19	;	;	PUNCT	,	_	_	_	_	_
20	and	and	CCONJ	CC	_	_	_	_	_
21	Jak1	Jak1	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
22	,	,	PUNCT	,	_	_	_	_	_
23	Jak3	Jak3	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
24	,	,	PUNCT	,	_	_	_	_	_
25	Stat1	stat1	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
26	,	,	PUNCT	,	_	_	_	_	_
27	Stat3	Stat3	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
28	,	,	PUNCT	,	_	_	_	_	_
29	and	and	CCONJ	CC	_	_	_	_	_
30	Stat5	Stat5	NUM	CD	NumType=Card	_	_	_	_
31	expression	expression	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
32	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3411
# text = The observed phenomena might be caused by downregulation of an IL-2R regulation gene, and might play a key role in the expansion of choriocarcinoma, and possibly in the survival of the fetal allograft.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	observed	observed	ADJ	JJ	Degree=Pos	_	_	_	_
3	phenomena	phenomena	NOUN	NN	Number=Sing	_	_	_	_
4	might	might	AUX	MD	VerbForm=Fin	_	_	_	_
5	be	be	AUX	VB	VerbForm=Inf	_	_	_	_
6	caused	cause	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
7	by	by	ADP	IN	_	_	_	_	_
8	downregulation	downregulation	NOUN	NN	Number=Sing	_	_	_	_
9	of	of	ADP	IN	_	_	_	_	_
10	an	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
11	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
12	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
13	2R	2R	PROPN	NNP	Number=Sing	_	_	_	_
14	regulation	regulation	NOUN	NN	Number=Sing	_	_	_	_
15	gene	gene	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
16	,	,	PUNCT	,	_	_	_	_	_
17	and	and	CCONJ	CC	_	_	_	_	_
18	might	might	AUX	MD	VerbForm=Fin	_	_	_	_
19	play	play	VERB	VB	VerbForm=Inf	_	_	_	_
20	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
21	key	key	ADJ	JJ	Degree=Pos	_	_	_	_
22	role	role	NOUN	NN	Number=Sing	_	_	_	_
23	in	in	ADP	IN	_	_	_	_	_
24	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
25	expansion	expansion	NOUN	NN	Number=Sing	_	_	_	_
26	of	of	ADP	IN	_	_	_	_	_
27	choriocarcinoma	choriocarcinoma	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
28	,	,	PUNCT	,	_	_	_	_	_
29	and	and	CCONJ	CC	_	_	_	_	_
30	possibly	possibly	ADV	RB	_	_	_	_	_
31	in	in	ADP	IN	_	_	_	_	_
32	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
33	survival	survival	NOUN	NN	Number=Sing	_	_	_	_
34	of	of	ADP	IN	_	_	_	_	_
35	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
36	fetal	fetal	ADJ	JJ	Degree=Pos	_	_	_	_
37	allograft	allograft	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
38	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 3412
# text = Document 003003459 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	003003459	003003459	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 3413
# text = Signal transduction through interferon-gamma receptor on human eosinophils.
1	Signal	signal	ADJ	JJ	Degree=Pos	_	_	_	_
2	transduction	transduction	NOUN	NN	Number=Sing	_	_	_	_
3	through	through	ADP	IN	_	_	_	_	_
4	interferon	interferon	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
5	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
6	gamma	gamma	NOUN	NN	Number=Sing	_	_	_	_
7	receptor	receptor	NOUN	NN	Number=Sing	_	_	_	_
8	on	on	ADP	IN	_	_	_	_	_
9	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
10	eosinophils	eosinophil	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
11	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 3414
# text = BACKGROUND:
1	BACKGROUND	background	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
2	:	:	PUNCT	:	_	_	_	_	_

# sent_id = 3415
# text = We reported on the constitutive interferon-gamma receptor (IFN-gammaR) expression on eosinophils.
1	We	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
2	reported	report	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
3	on	on	ADP	IN	_	_	_	_	_
4	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
5	constitutive	constitutive	ADJ	JJ	Degree=Pos	_	_	_	_
6	interferon	interferon	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
7	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
8	gamma	gamma	NOUN	NN	Number=Sing	_	_	_	_
9	receptor	receptor	NOUN	NN	Number=Sing	_	_	_	_
10	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
11	IFN	Ifn	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
12	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
13	gammaR	gammar	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
14	)	)	PUNCT	-RRB-	_	_	_	_	_
15	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
16	on	on	ADP	IN	_	_	_	_	_
17	eosinophils	eosinophil	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
18	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3416
# text = But signal transduction through IFN-gammaR on eosinophils remains to be elucidated.
1	But	but	CCONJ	CC	_	_	_	_	_
2	signal	signal	VERB	VB	Mood=Imp|VerbForm=Fin	_	_	_	_
3	transduction	transduction	NOUN	NN	Number=Sing	_	_	_	_
4	through	through	ADP	IN	_	_	_	_	_
5	IFN	IFN	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
6	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
7	gammaR	gammar	NOUN	NN	Number=Sing	_	_	_	_
8	on	on	ADP	IN	_	_	_	_	_
9	eosinophils	eosinophil	NOUN	NNS	Number=Plur	_	_	_	_
10	remains	remain	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
11	to	to	PART	TO	_	_	_	_	_
12	be	be	AUX	VB	VerbForm=Inf	_	_	_	_
13	elucidated	elucidate	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	SpaceAfter=No
14	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3417
# text = In this study, we examined the involvement of the Jak/Stat pathway in the signaling of eosinophils after IFN-gammaR conjugation by the ligand binding.
1	In	in	ADP	IN	_	_	_	_	_
2	this	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
3	study	study	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
4	,	,	PUNCT	,	_	_	_	_	_
5	we	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
6	examined	examin	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
7	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
8	involvement	involvement	NOUN	NN	Number=Sing	_	_	_	_
9	of	of	ADP	IN	_	_	_	_	_
10	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
11	Jak	Jak	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
12	/	/	PUNCT	,	_	_	_	_	SpaceAfter=No
13	Stat	Stat	PROPN	NNP	Number=Sing	_	_	_	_
14	pathway	pathway	NOUN	NN	Number=Sing	_	_	_	_
15	in	in	ADP	IN	_	_	_	_	_
16	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
17	signaling	signaling	NOUN	NN	Number=Sing	_	_	_	_
18	of	of	ADP	IN	_	_	_	_	_
19	eosinophils	eosinophil	NOUN	NNS	Number=Plur	_	_	_	_
20	after	after	ADP	IN	_	_	_	_	_
21	IFN	IFN	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
22	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
23	gammaR	gammaR	PROPN	NNP	Number=Sing	_	_	_	_
24	conjugation	conjugation	NOUN	NN	Number=Sing	_	_	_	_
25	by	by	ADP	IN	_	_	_	_	_
26	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
27	ligand	ligand	NOUN	NN	Number=Sing	_	_	_	_
28	binding	binding	VERB	VBG	VerbForm=Ger	_	_	_	SpaceAfter=No
29	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3418
# text = METHODS: Purified peripheral eosinophils were stimulated with IFN-gamma at 37 degrees C for 1-60 min.
1	METHODS	method	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
2	:	:	PUNCT	:	_	_	_	_	_
3	Purified	Purify	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
4	peripheral	peripheral	ADJ	JJ	Degree=Pos	_	_	_	_
5	eosinophils	eosinophil	NOUN	NNS	Number=Plur	_	_	_	_
6	were	be	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
7	stimulated	stimulate	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
8	with	with	ADP	IN	_	_	_	_	_
9	IFN	IFN	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
10	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
11	gamma	gamma	NOUN	NN	Number=Sing	_	_	_	_
12	at	at	ADP	IN	_	_	_	_	_
13	37	37	NUM	CD	NumType=Card	_	_	_	_
14	degrees	degree	NOUN	NNS	Number=Plur	_	_	_	_
15	C	C	PROPN	NNP	Number=Sing	_	_	_	_
16	for	for	ADP	IN	_	_	_	_	_
17	1	1	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
18	-	-	SYM	SYM	_	_	_	_	SpaceAfter=No
19	60	60	NUM	CD	NumType=Card	_	_	_	_
20	min	min	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
21	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3419
# text = Tyrosine phosphorylation of IFN-gammaR, Jak1, Jak2, and Stat1alpha was examined by immunoblotting.
1	Tyrosine	Tyrosine	NOUN	NN	Number=Sing	_	_	_	_
2	phosphorylation	phosphorylation	NOUN	NN	Number=Sing	_	_	_	_
3	of	of	ADP	IN	_	_	_	_	_
4	IFN	IFN	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
5	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
6	gammaR	gammaR	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
7	,	,	PUNCT	,	_	_	_	_	_
8	Jak1	Jak1	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
9	,	,	PUNCT	,	_	_	_	_	_
10	Jak2	jak2	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
11	,	,	PUNCT	,	_	_	_	_	_
12	and	and	CCONJ	CC	_	_	_	_	_
13	Stat1	stat1	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
14	alpha	alpha	PROPN	NNP	Number=Sing	_	_	_	_
15	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
16	examined	examin	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
17	by	by	SCONJ	IN	_	_	_	_	_
18	immunoblotting	immunoblott	VERB	VBG	VerbForm=Ger	_	_	_	SpaceAfter=No
19	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3420
# text = Gel-shift assay was also examined to show the formation of Stat1alpha-DNA complexes.
1	Gel	gel	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
2	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
3	shift	shift	NOUN	NN	Number=Sing	_	_	_	_
4	assay	assay	NOUN	NN	Number=Sing	_	_	_	_
5	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
6	also	also	ADV	RB	_	_	_	_	_
7	examined	examin	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
8	to	to	PART	TO	_	_	_	_	_
9	show	show	VERB	VB	VerbForm=Inf	_	_	_	_
10	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
11	formation	formation	NOUN	NN	Number=Sing	_	_	_	_
12	of	of	ADP	IN	_	_	_	_	_
13	Stat1	Stat1	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
14	alpha	alpha	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
15	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
16	DNA	dna	NOUN	NN	Number=Sing	_	_	_	_
17	complexes	complex	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
18	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3421
# text = RESULTS: We show that binding of IFN-gamma to human eosinophils initiated a series of events that resulted in the rapid tyrosine phosphorylation of not only the IFN-gammaRalpha chain but also Jak1, Jak2, and Stat1alpha.
1	RESULTS	result	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
2	:	:	PUNCT	:	_	_	_	_	_
3	We	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
4	show	show	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
5	that	that	SCONJ	IN	_	_	_	_	_
6	binding	bind	VERB	VBG	VerbForm=Ger	_	_	_	_
7	of	of	ADP	IN	_	_	_	_	_
8	IFN	IFN	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
9	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
10	gamma	gamma	NOUN	NN	Number=Sing	_	_	_	_
11	to	to	ADP	IN	_	_	_	_	_
12	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
13	eosinophils	eosinophil	NOUN	NNS	Number=Plur	_	_	_	_
14	initiated	initiate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
15	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
16	series	series	NOUN	NN	Number=Sing	_	_	_	_
17	of	of	ADP	IN	_	_	_	_	_
18	events	event	NOUN	NNS	Number=Plur	_	_	_	_
19	that	that	PRON	WDT	PronType=Rel	_	_	_	_
20	resulted	result	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
21	in	in	ADP	IN	_	_	_	_	_
22	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
23	rapid	rapid	ADJ	JJ	Degree=Pos	_	_	_	_
24	tyrosine	tyrosine	NOUN	NN	Number=Sing	_	_	_	_
25	phosphorylation	phosphorylation	NOUN	NN	Number=Sing	_	_	_	_
26	of	of	ADP	IN	_	_	_	_	_
27	not	not	ADV	RB	_	_	_	_	_
28	only	only	ADV	RB	_	_	_	_	_
29	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
30	IFN	IFN	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
31	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
32	gammaRalpha	gammaRalpha	PROPN	NNP	Number=Sing	_	_	_	_
33	chain	chain	NOUN	NN	Number=Sing	_	_	_	_
34	but	but	CCONJ	CC	_	_	_	_	_
35	also	also	ADV	RB	_	_	_	_	_
36	Jak1	Jak1	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
37	,	,	PUNCT	,	_	_	_	_	_
38	Jak2	Jak2	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
39	,	,	PUNCT	,	_	_	_	_	_
40	and	and	CCONJ	CC	_	_	_	_	_
41	Stat1	Stat1	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
42	alpha	alpha	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
43	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3422
# text = In addition, IFN-gamma enhanced the DNA-binding activity of Stat1alpha.
1	In	in	ADP	IN	_	_	_	_	_
2	addition	addition	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
3	,	,	PUNCT	,	_	_	_	_	_
4	IFN	IFN	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
5	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
6	gamma	gamma	NOUN	NN	Number=Sing	_	_	_	_
7	enhanced	enhance	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
8	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
9	DNA	dna	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
10	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
11	binding	bind	VERB	VBG	VerbForm=Ger	_	_	_	_
12	activity	activity	NOUN	NN	Number=Sing	_	_	_	_
13	of	of	ADP	IN	_	_	_	_	_
14	Stat1	Stat1	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
15	alpha	alpha	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
16	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3423
# text = CONCLUSION:
1	CONCLUSION	conclusion	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
2	:	:	PUNCT	:	_	_	_	_	_

# sent_id = 3424
# text = These data indicate that IFN-gamma affects eosinophils through its specific receptor and utilizes the Jak/Stat pathway as its mode of signaling.
1	These	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
2	data	data	NOUN	NN	Number=Sing	_	_	_	_
3	indicate	indicate	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
4	that	that	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
5	IFN	Ifn	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
6	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
7	gamma	gamma	NOUN	NN	Number=Sing	_	_	_	_
8	affects	affect	NOUN	NNS	Number=Plur	_	_	_	_
9	eosinophils	eosinophil	NOUN	NNS	Number=Plur	_	_	_	_
10	through	through	ADP	IN	_	_	_	_	_
11	its	its	PRON	PRP$	Gender=Neut|Number=Sing|Person=3|Poss=Yes|PronType=Prs	_	_	_	_
12	specific	specific	ADJ	JJ	Degree=Pos	_	_	_	_
13	receptor	receptor	NOUN	NN	Number=Sing	_	_	_	_
14	and	and	CCONJ	CC	_	_	_	_	_
15	utilizes	utilize	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
16	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
17	Jak	Jak	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
18	/	/	PUNCT	,	_	_	_	_	SpaceAfter=No
19	Stat	Stat	PROPN	NNP	Number=Sing	_	_	_	_
20	pathway	pathway	NOUN	NN	Number=Sing	_	_	_	_
21	as	as	SCONJ	IN	_	_	_	_	_
22	its	its	PRON	PRP$	Gender=Neut|Number=Sing|Person=3|Poss=Yes|PronType=Prs	_	_	_	_
23	mode	mode	NOUN	NN	Number=Sing	_	_	_	_
24	of	of	ADP	IN	_	_	_	_	_
25	signaling	signaling	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
26	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 3425
# text = Document 003003462 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	003003462	003003462	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 3426
# text = Ras oncogene transformation of human B lymphoblasts is associated with lymphocyte activation and with a block of differentiation.
1	Ras	Ras	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
2	oncogene	oncogene	ADJ	JJ	Degree=Pos	_	_	_	_
3	transformation	transformation	NOUN	NN	Number=Sing	_	_	_	_
4	of	of	ADP	IN	_	_	_	_	_
5	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
6	B	b	NOUN	NN	Number=Sing	_	_	_	_
7	lymphoblasts	lymphoblast	NOUN	NNS	Number=Plur	_	_	_	_
8	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
9	associated	associate	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
10	with	with	ADP	IN	_	_	_	_	_
11	lymphocyte	lymphocyte	NOUN	NN	Number=Sing	_	_	_	_
12	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
13	and	and	CCONJ	CC	_	_	_	_	_
14	with	with	ADP	IN	_	_	_	_	_
15	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
16	block	block	NOUN	NN	Number=Sing	_	_	_	_
17	of	of	ADP	IN	_	_	_	_	_
18	differentiation	differentiation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
19	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 3427
# text = The p21ras small GTP binding proteins participate in signal transduction from cell surface receptors and affect neoplastic transformation and development in many different cell types.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	p21ras	p21ra	NOUN	NNS	Number=Plur	_	_	_	_
3	small	small	ADJ	JJ	Degree=Pos	_	_	_	_
4	GTP	Gtp	NOUN	NN	Number=Sing	_	_	_	_
5	binding	bind	VERB	VBG	VerbForm=Ger	_	_	_	_
6	proteins	protein	NOUN	NNS	Number=Plur	_	_	_	_
7	participate	participate	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
8	in	in	ADP	IN	_	_	_	_	_
9	signal	signal	NOUN	NN	Number=Sing	_	_	_	_
10	transduction	transduction	NOUN	NN	Number=Sing	_	_	_	_
11	from	from	ADP	IN	_	_	_	_	_
12	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
13	surface	surface	NOUN	NN	Number=Sing	_	_	_	_
14	receptors	receptor	NOUN	NNS	Number=Plur	_	_	_	_
15	and	and	CCONJ	CC	_	_	_	_	_
16	affect	affect	ADJ	JJ	Degree=Pos	_	_	_	_
17	neoplastic	neoplastic	ADJ	JJ	Degree=Pos	_	_	_	_
18	transformation	transformation	NOUN	NN	Number=Sing	_	_	_	_
19	and	and	CCONJ	CC	_	_	_	_	_
20	development	development	NOUN	NN	Number=Sing	_	_	_	_
21	in	in	ADP	IN	_	_	_	_	_
22	many	many	ADJ	JJ	Degree=Pos	_	_	_	_
23	different	different	ADJ	JJ	Degree=Pos	_	_	_	_
24	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
25	types	type	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
26	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3428
# text = In the present study, we examined the relationship between ras transformation and differentiation of human B lymphocytes.
1	In	in	ADP	IN	_	_	_	_	_
2	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
3	present	present	ADJ	JJ	Degree=Pos	_	_	_	_
4	study	study	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
5	,	,	PUNCT	,	_	_	_	_	_
6	we	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
7	examined	examin	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
8	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
9	relationship	relationship	NOUN	NN	Number=Sing	_	_	_	_
10	between	between	ADP	IN	_	_	_	_	_
11	ras	ras	NOUN	NN	Number=Sing	_	_	_	_
12	transformation	transformation	NOUN	NN	Number=Sing	_	_	_	_
13	and	and	CCONJ	CC	_	_	_	_	_
14	differentiation	differentiation	NOUN	NN	Number=Sing	_	_	_	_
15	of	of	ADP	IN	_	_	_	_	_
16	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
17	B	b	NOUN	NN	Number=Sing	_	_	_	_
18	lymphocytes	lymphocyte	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
19	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3429
# text = We show that the constitutive expression of the T24 Ha-ras oncogene in EBV-immortalized B lymphoblasts was associated with the induction of the interleukin 2 receptor alpha subunit, with an impaired immunoglobulin gene expression, altered adhesion properties and increased survival in serum-free medium.
1	We	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
2	show	show	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
3	that	that	SCONJ	IN	_	_	_	_	_
4	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
5	constitutive	constitutive	ADJ	JJ	Degree=Pos	_	_	_	_
6	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
7	of	of	ADP	IN	_	_	_	_	_
8	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
9	T24	t24	NUM	CD	NumType=Card	_	_	_	_
10	Ha-	Ha-	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
11	ras	ra	NOUN	NNS	Number=Plur	_	_	_	_
12	oncogene	oncogene	ADV	RB	_	_	_	_	_
13	in	in	ADP	IN	_	_	_	_	_
14	EBV	EBV	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
15	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
16	immortalized	immortalize	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
17	B	b	NOUN	NN	Number=Sing	_	_	_	_
18	lymphoblasts	lymphoblast	NOUN	NNS	Number=Plur	_	_	_	_
19	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
20	associated	associate	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
21	with	with	ADP	IN	_	_	_	_	_
22	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
23	induction	induction	NOUN	NN	Number=Sing	_	_	_	_
24	of	of	ADP	IN	_	_	_	_	_
25	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
26	interleukin	interleukin	NOUN	NN	Number=Sing	_	_	_	_
27	2	2	NUM	CD	NumType=Card	_	_	_	_
28	receptor	receptor	NOUN	NN	Number=Sing	_	_	_	_
29	alpha	alpha	ADP	IN	_	_	_	_	_
30	subunit	subunit	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
31	,	,	PUNCT	,	_	_	_	_	_
32	with	with	ADP	IN	_	_	_	_	_
33	an	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
34	impaired	impaire	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
35	immunoglobulin	immunoglobulin	ADJ	JJ	Degree=Pos	_	_	_	_
36	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
37	expression	expression	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
38	,	,	PUNCT	,	_	_	_	_	_
39	altered	alter	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
40	adhesion	adhesion	NOUN	NN	Number=Sing	_	_	_	_
41	properties	property	NOUN	NNS	Number=Plur	_	_	_	_
42	and	and	CCONJ	CC	_	_	_	_	_
43	increased	increase	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
44	survival	survival	NOUN	NN	Number=Sing	_	_	_	_
45	in	in	ADP	IN	_	_	_	_	_
46	serum	serum	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
47	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
48	free	free	ADJ	JJ	Degree=Pos	_	_	_	_
49	medium	medium	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
50	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3430
# text = Since induction of the IL-2 receptor alpha subunit is a hallmark of lymphocyte activation, we suggest that p21ras naturally triggers B cell activation.
1	Since	since	ADP	IN	_	_	_	_	_
2	induction	induction	NOUN	NN	Number=Sing	_	_	_	_
3	of	of	ADP	IN	_	_	_	_	_
4	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
5	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
6	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
7	2	2	NUM	CD	NumType=Card	_	_	_	_
8	receptor	receptor	NOUN	NN	Number=Sing	_	_	_	_
9	alpha	alpha	NOUN	NN	Number=Sing	_	_	_	_
10	subunit	subunit	NOUN	NN	Number=Sing	_	_	_	_
11	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
12	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
13	hallmark	hallmark	NOUN	NN	Number=Sing	_	_	_	_
14	of	of	ADP	IN	_	_	_	_	_
15	lymphocyte	lymphocyte	NOUN	NN	Number=Sing	_	_	_	_
16	activation	activation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
17	,	,	PUNCT	,	_	_	_	_	_
18	we	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
19	suggest	suggest	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
20	that	that	PRON	DT	Number=Sing|PronType=Dem	_	_	_	_
21	p21ras	p21ras	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
22	naturally	naturally	ADV	RB	_	_	_	_	_
23	triggers	trigger	NOUN	NNS	Number=Plur	_	_	_	_
24	B	b	ADJ	JJ	Degree=Pos	_	_	_	_
25	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
26	activation	activation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
27	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3431
# text = The ras-transformed lymphocytes displayed a fully functional IL-2r, as assessed by c-fos induction following treatment with IL-2; nevertheless, they were not growth stimulated by this lymphokine.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	ras	ra	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
3	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
4	transformed	transform	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
5	lymphocytes	lymphocyte	NOUN	NNS	Number=Plur	_	_	_	_
6	displayed	display	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
7	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
8	fully	fully	ADV	RB	_	_	_	_	_
9	functional	functional	ADJ	JJ	Degree=Pos	_	_	_	_
10	IL	Il	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
11	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
12	2r	2r	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
13	,	,	PUNCT	,	_	_	_	_	_
14	as	as	SCONJ	IN	_	_	_	_	_
15	assessed	assess	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
16	by	by	ADP	IN	_	_	_	_	_
17	c	c	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
18	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
19	fos	fos	NOUN	NN	Number=Sing	_	_	_	_
20	induction	induction	NOUN	NN	Number=Sing	_	_	_	_
21	following	follow	VERB	VBG	VerbForm=Ger	_	_	_	_
22	treatment	treatment	NOUN	NN	Number=Sing	_	_	_	_
23	with	with	ADP	IN	_	_	_	_	_
24	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
25	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
26	2	2	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
27	;	;	PUNCT	,	_	_	_	_	_
28	nevertheless	nevertheless	ADV	RB	_	_	_	_	SpaceAfter=No
29	,	,	PUNCT	,	_	_	_	_	_
30	they	they	PRON	PRP	Case=Nom|Number=Plur|Person=3|PronType=Prs	_	_	_	_
31	were	be	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
32	not	not	PART	RB	_	_	_	_	_
33	growth	growth	ADV	RB	_	_	_	_	_
34	stimulated	stimulate	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
35	by	by	ADP	IN	_	_	_	_	_
36	this	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
37	lymphokine	lymphokine	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
38	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3432
# text = The decreased expression of immunoglobulin genes indicates that the ras oncogene blocks terminal differentiation to plasma cells, possibly by inhibiting the activity of lymphocyte-specific transcription factors.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	decreased	decrease	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
3	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
4	of	of	ADP	IN	_	_	_	_	_
5	immunoglobulin	immunoglobulin	ADJ	JJ	Degree=Pos	_	_	_	_
6	genes	gene	NOUN	NNS	Number=Plur	_	_	_	_
7	indicates	indicate	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
8	that	that	SCONJ	IN	_	_	_	_	_
9	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
10	ras	ra	NOUN	NNS	Number=Plur	_	_	_	_
11	oncogene	oncogene	PRON	PRP	_	_	_	_	_
12	blocks	block	NOUN	NNS	Number=Plur	_	_	_	_
13	terminal	terminal	ADJ	JJ	Degree=Pos	_	_	_	_
14	differentiation	differentiation	NOUN	NN	Number=Sing	_	_	_	_
15	to	to	ADP	IN	_	_	_	_	_
16	plasma	plasma	NOUN	NN	Number=Sing	_	_	_	_
17	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
18	,	,	PUNCT	,	_	_	_	_	_
19	possibly	possibly	ADV	RB	_	_	_	_	_
20	by	by	SCONJ	IN	_	_	_	_	_
21	inhibiting	inhibit	VERB	VBG	VerbForm=Ger	_	_	_	_
22	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
23	activity	activity	NOUN	NN	Number=Sing	_	_	_	_
24	of	of	ADP	IN	_	_	_	_	_
25	lymphocyte	lymphocyte	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
26	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
27	specific	specific	ADJ	JJ	Degree=Pos	_	_	_	_
28	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
29	factors	factor	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
30	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3433
# text = Somewhat unexpectedly, the constitutive p21ras activity did not cause an increased DNA binding of transcription factors PEA1 (AP1), PEA3, Oct-2 or NF-kB.
1	Somewhat	somewhat	ADV	RB	_	_	_	_	_
2	unexpectedly	unexpectedly	ADV	RB	_	_	_	_	SpaceAfter=No
3	,	,	PUNCT	,	_	_	_	_	_
4	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
5	constitutive	constitutive	ADJ	JJ	Degree=Pos	_	_	_	_
6	p21ras	p21ras	NOUN	NNS	Number=Plur	_	_	_	_
7	activity	activity	NOUN	NN	Number=Sing	_	_	_	_
8	did	do	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
9	not	not	PART	RB	_	_	_	_	_
10	cause	cause	VERB	VB	VerbForm=Inf	_	_	_	_
11	an	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
12	increased	increase	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
13	DNA	dna	NOUN	NN	Number=Sing	_	_	_	_
14	binding	binding	VERB	VBG	VerbForm=Ger	_	_	_	_
15	of	of	ADP	IN	_	_	_	_	_
16	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
17	factors	factor	NOUN	NNS	Number=Plur	_	_	_	_
18	PEA1	PEA1	PROPN	NNP	Number=Sing	_	_	_	_
19	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
20	AP1	AP1	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
21	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
22	,	,	PUNCT	,	_	_	_	_	_
23	PEA3	PEA3	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
24	,	,	PUNCT	,	_	_	_	_	_
25	Oct	Oct	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
26	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
27	2	2	NUM	CD	NumType=Card	_	_	_	_
28	or	or	CCONJ	CC	_	_	_	_	_
29	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
30	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
31	kB.	kB.	PROPN	NNP	Number=Sing	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 3434
# text = Document 003003463 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	003003463	003003463	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 3435
# text = Inhibition of dexamethasone binding to human glucocorticoid receptor by New World primate cell extracts.
1	Inhibition	Inhibition	NOUN	NN	Number=Sing	_	_	_	_
2	of	of	ADP	IN	_	_	_	_	_
3	dexamethasone	dexamethasone	NOUN	NN	Number=Sing	_	_	_	_
4	binding	bind	VERB	VBG	VerbForm=Ger	_	_	_	_
5	to	to	ADP	IN	_	_	_	_	_
6	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
7	glucocorticoid	glucocorticoid	NOUN	NN	Number=Sing	_	_	_	_
8	receptor	receptor	NOUN	NN	Number=Sing	_	_	_	_
9	by	by	ADP	IN	_	_	_	_	_
10	New	New	PROPN	NNP	Number=Sing	_	_	_	_
11	World	World	PROPN	NNP	Number=Sing	_	_	_	_
12	primate	primate	ADJ	JJ	Degree=Pos	_	_	_	_
13	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
14	extracts	extract	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
15	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 3436
# text = To determine if New World primates express an inhibitor that influences glucocorticoid receptor (GR) binding characteristics, we examined [3H]dexamethasone binding in cytosol prepared from B95-8 lymphoid cells, derived from the cotton top tamarin (Saguinus oedipus), in combination with cytosol prepared from human or rat tissues.
1	To	to	PART	TO	_	_	_	_	_
2	determine	determine	VERB	VB	VerbForm=Inf	_	_	_	_
3	if	if	SCONJ	IN	_	_	_	_	_
4	New	New	PROPN	NNP	Number=Sing	_	_	_	_
5	World	world	PROPN	NNP	Number=Sing	_	_	_	_
6	primates	primate	NOUN	NNS	Number=Plur	_	_	_	_
7	express	express	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
8	an	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
9	inhibitor	inhibitor	NOUN	NN	Number=Sing	_	_	_	_
10	that	that	PRON	WDT	PronType=Rel	_	_	_	_
11	influences	influence	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
12	glucocorticoid	glucocorticoid	ADJ	JJ	Degree=Pos	_	_	_	_
13	receptor	receptor	NOUN	NN	Number=Sing	_	_	_	_
14	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
15	GR	GR	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
16	)	)	PUNCT	-RRB-	_	_	_	_	_
17	binding	binding	VERB	VBG	VerbForm=Ger	_	_	_	_
18	characteristics	characteristic	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
19	,	,	PUNCT	,	_	_	_	_	_
20	we	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
21	examined	examin	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
22	[	[	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
23	3H]	3h]	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
24	dexamethasone	dexamethasone	NOUN	NN	Number=Sing	_	_	_	_
25	binding	bind	VERB	VBG	VerbForm=Ger	_	_	_	_
26	in	in	ADP	IN	_	_	_	_	_
27	cytosol	cytosol	NOUN	NN	Number=Sing	_	_	_	_
28	prepared	prepare	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
29	from	from	ADP	IN	_	_	_	_	_
30	B95	B95	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
31	-	-	SYM	SYM	_	_	_	_	SpaceAfter=No
32	8	8	NUM	CD	NumType=Card	_	_	_	_
33	lymphoid	lymphoid	ADJ	JJ	Degree=Pos	_	_	_	_
34	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
35	,	,	PUNCT	,	_	_	_	_	_
36	derived	derive	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
37	from	from	ADP	IN	_	_	_	_	_
38	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
39	cotton	cotton	NOUN	NN	Number=Sing	_	_	_	_
40	top	top	NOUN	NN	Number=Sing	_	_	_	_
41	tamarin	tamarin	NOUN	NN	Number=Sing	_	_	_	_
42	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
43	Saguinus	Saguinus	ADJ	JJ	Degree=Pos	_	_	_	_
44	oedipus	oedipus	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
45	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
46	,	,	PUNCT	,	_	_	_	_	_
47	in	in	ADP	IN	_	_	_	_	_
48	combination	combination	NOUN	NN	Number=Sing	_	_	_	_
49	with	with	ADP	IN	_	_	_	_	_
50	cytosol	cytosol	NOUN	NN	Number=Sing	_	_	_	_
51	prepared	prepare	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
52	from	from	ADP	IN	_	_	_	_	_
53	human	human	NOUN	NN	Number=Sing	_	_	_	_
54	or	or	CCONJ	CC	_	_	_	_	_
55	rat	rat	NOUN	NN	Number=Sing	_	_	_	_
56	tissues	tissue	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
57	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3437
# text = B95-8 cytosol inhibited specific binding of [3H]dexamethasone (P < 0.01) when mixed with cytosol prepared from either a human lymphoid cell line (HL) or rat thymus.
1	B95	B95	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
2	-	-	SYM	SYM	_	_	_	_	SpaceAfter=No
3	8	8	NUM	CD	NumType=Card	_	_	_	_
4	cytosol	cytosol	NOUN	NN	Number=Sing	_	_	_	_
5	inhibited	inhibit	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
6	specific	specific	ADJ	JJ	Degree=Pos	_	_	_	_
7	binding	binding	NOUN	NN	Number=Sing	_	_	_	_
8	of	of	ADP	IN	_	_	_	_	_
9	[	[	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
10	3H	3H	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
11	]	]	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
12	dexamethasone	dexamethasone	NOUN	NN	Number=Sing	_	_	_	_
13	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
14	P	p	NOUN	NN	Number=Sing	_	_	_	_
15	<	<	PUNCT	-LRB-	_	_	_	_	_
16	0.01	0.01	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
17	)	)	PUNCT	-RRB-	_	_	_	_	_
18	when	when	ADV	WRB	PronType=Int	_	_	_	_
19	mixed	mix	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
20	with	with	ADP	IN	_	_	_	_	_
21	cytosol	cytosol	NOUN	NN	Number=Sing	_	_	_	_
22	prepared	prepare	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
23	from	from	ADP	IN	_	_	_	_	_
24	either	either	CCONJ	CC	_	_	_	_	_
25	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
26	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
27	lymphoid	lymphoid	NOUN	NN	Number=Sing	_	_	_	_
28	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
29	line	line	NOUN	NN	Number=Sing	_	_	_	_
30	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
31	HL	HL	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
32	)	)	PUNCT	-RRB-	_	_	_	_	_
33	or	or	CCONJ	CC	_	_	_	_	_
34	rat	rat	NOUN	NN	Number=Sing	_	_	_	_
35	thymus	thymus	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
36	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3438
# text = The inhibitory activity was heat labile and trypsin sensitive.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	inhibitory	inhibitory	ADJ	JJ	Degree=Pos	_	_	_	_
3	activity	activity	NOUN	NN	Number=Sing	_	_	_	_
4	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
5	heat	heat	NOUN	NN	Number=Sing	_	_	_	_
6	labile	labile	NOUN	NN	Number=Sing	_	_	_	_
7	and	and	CCONJ	CC	_	_	_	_	_
8	trypsin	trypsin	VERB	VB	VerbForm=Inf	_	_	_	_
9	sensitive	sensitive	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
10	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3439
# text = Peak inhibitory activity was found in the 150-200 kd fractions after Sephacryl G-200 ultrafiltration.
1	Peak	peak	PROPN	NNP	Number=Sing	_	_	_	_
2	inhibitory	inhibitory	ADJ	JJ	Degree=Pos	_	_	_	_
3	activity	activity	NOUN	NN	Number=Sing	_	_	_	_
4	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
5	found	find	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
6	in	in	ADP	IN	_	_	_	_	_
7	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
8	150	150	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
9	-	-	SYM	SYM	_	_	_	_	SpaceAfter=No
10	200	200	NUM	CD	NumType=Card	_	_	_	_
11	kd	k	ADJ	JJ	Degree=Pos	_	_	_	_
12	fractions	fraction	NOUN	NNS	Number=Plur	_	_	_	_
13	after	after	ADP	IN	_	_	_	_	_
14	Sephacryl	Sephacryl	PROPN	NNP	Number=Sing	_	_	_	_
15	G	G	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
16	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
17	200	200	NUM	CD	NumType=Card	_	_	_	_
18	ultrafiltration	ultrafiltration	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
19	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3440
# text = Scatchard analysis of [3H]dexamethasone binding using mixed cytosol showed a diminished GR apparent binding affinity when compared to HL cytosol.
1	Scatchard	Scatchard	ADJ	JJ	Degree=Pos	_	_	_	_
2	analysis	analysis	NOUN	NN	Number=Sing	_	_	_	_
3	of	of	ADP	IN	_	_	_	_	_
4	[	[	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
5	3H	3H	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
6	]	]	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
7	dexamethasone	dexamethasone	NOUN	NN	Number=Sing	_	_	_	_
8	binding	binding	VERB	VBG	VerbForm=Ger	_	_	_	_
9	using	use	VERB	VBG	VerbForm=Ger	_	_	_	_
10	mixed	mix	ADJ	JJ	Degree=Pos	_	_	_	_
11	cytosol	cytosol	NOUN	NN	Number=Sing	_	_	_	_
12	showed	show	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
13	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
14	diminished	diminish	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
15	GR	Gr	NOUN	NN	Number=Sing	_	_	_	_
16	apparent	apparent	NOUN	NN	Number=Sing	_	_	_	_
17	binding	binde	VERB	VBG	VerbForm=Ger	_	_	_	_
18	affinity	affinity	NOUN	NN	Number=Sing	_	_	_	_
19	when	when	ADV	WRB	PronType=Int	_	_	_	_
20	compared	compare	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
21	to	to	ADP	IN	_	_	_	_	_
22	HL	Hl	PROPN	NNP	Number=Sing	_	_	_	_
23	cytosol	cytosol	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
24	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3441
# text = Kinetic studies using mixed cytosol indicated that B95-8 cytosol did not affect the apparent dissociation rate of [3H]dexamethasone.
1	Kinetic	Kinetic	ADJ	JJ	Degree=Pos	_	_	_	_
2	studies	study	NOUN	NNS	Number=Plur	_	_	_	_
3	using	use	VERB	VBG	VerbForm=Ger	_	_	_	_
4	mixed	mix	ADJ	JJ	Degree=Pos	_	_	_	_
5	cytosol	cytosol	NOUN	NN	Number=Sing	_	_	_	_
6	indicated	indicate	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
7	that	that	SCONJ	IN	_	_	_	_	_
8	B95	B95	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
9	-	-	SYM	SYM	_	_	_	_	SpaceAfter=No
10	8	8	NUM	CD	NumType=Card	_	_	_	_
11	cytosol	cytosol	NOUN	NN	Number=Sing	_	_	_	_
12	did	do	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
13	not	not	PART	RB	_	_	_	_	_
14	affect	affect	VERB	VB	VerbForm=Inf	_	_	_	_
15	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
16	apparent	apparent	ADJ	JJ	Degree=Pos	_	_	_	_
17	dissociation	dissociation	NOUN	NN	Number=Sing	_	_	_	_
18	rate	rate	NOUN	NN	Number=Sing	_	_	_	_
19	of	of	ADP	IN	_	_	_	_	_
20	[	[	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
21	3H]	3h]	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
22	dexamethasone	dexamethasone	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
23	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3442
# text = These data demonstrate that B95-8 cells contain a competitive inhibitor that prevents binding of dexamethasone to its cognate receptor.
1	These	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
2	data	data	NOUN	NN	Number=Sing	_	_	_	_
3	demonstrate	demonstrate	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
4	that	that	SCONJ	IN	_	_	_	_	_
5	B95	B95	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
6	-	-	SYM	SYM	_	_	_	_	SpaceAfter=No
7	8	8	NUM	CD	NumType=Card	_	_	_	_
8	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
9	contain	contain	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
10	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
11	competitive	competitive	ADJ	JJ	Degree=Pos	_	_	_	_
12	inhibitor	inhibitor	NOUN	NN	Number=Sing	_	_	_	_
13	that	that	SCONJ	IN	_	_	_	_	_
14	prevents	prevent	NOUN	NNS	Number=Plur	_	_	_	_
15	binding	binding	VERB	VBG	VerbForm=Ger	_	_	_	_
16	of	of	ADP	IN	_	_	_	_	_
17	dexamethasone	dexamethasone	NOUN	NN	Number=Sing	_	_	_	_
18	to	to	ADP	IN	_	_	_	_	_
19	its	its	PRON	PRP$	Gender=Neut|Number=Sing|Person=3|Poss=Yes|PronType=Prs	_	_	_	_
20	cognate	cognate	ADJ	JJ	Degree=Pos	_	_	_	_
21	receptor	receptor	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
22	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 3443
# text = Document 003003465 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	003003465	003003465	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 3444
# text = Age-related decreases in IL-2 production by human T cells are associated with impaired activation of nuclear transcriptional factors AP-1 and NF-AT.
1	Age	age	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
2	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
3	related	related	ADJ	JJ	Degree=Pos	_	_	_	_
4	decreases	decrease	NOUN	NNS	Number=Plur	_	_	_	_
5	in	in	ADP	IN	_	_	_	_	_
6	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
7	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
8	2	2	NUM	CD	NumType=Card	_	_	_	_
9	production	production	NOUN	NN	Number=Sing	_	_	_	_
10	by	by	ADP	IN	_	_	_	_	_
11	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
12	T	t	PROPN	NNP	Number=Sing	_	_	_	_
13	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
14	are	be	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
15	associated	associate	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
16	with	with	ADP	IN	_	_	_	_	_
17	impaired	impaire	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
18	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
19	of	of	ADP	IN	_	_	_	_	_
20	nuclear	nuclear	ADJ	JJ	Degree=Pos	_	_	_	_
21	transcriptional	transcriptional	ADJ	JJ	Degree=Pos	_	_	_	_
22	factors	factor	NOUN	NNS	Number=Plur	_	_	_	_
23	AP	ap	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
24	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
25	1	1	NUM	CD	NumType=Card	_	_	_	_
26	and	and	CCONJ	CC	_	_	_	_	_
27	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
28	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
29	AT	AT	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
30	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 3445
# text = Although transcriptional factors AP-1 and nuclear factor of activated T cells (NF-AT) are important for the normal induction of IL-2, it is unknown if the age-related decline in IL-2 production by activated human T cells may be associated with aberrancies in transcriptional regulatory proteins.
1	Although	although	SCONJ	IN	_	_	_	_	_
2	transcriptional	transcriptional	ADJ	JJ	Degree=Pos	_	_	_	_
3	factors	factor	NOUN	NNS	Number=Plur	_	_	_	_
4	AP	ap	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
5	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
6	1	1	NUM	CD	NumType=Card	_	_	_	_
7	and	and	CCONJ	CC	_	_	_	_	_
8	nuclear	nuclear	ADJ	JJ	Degree=Pos	_	_	_	_
9	factor	factor	NOUN	NN	Number=Sing	_	_	_	_
10	of	of	ADP	IN	_	_	_	_	_
11	activated	activated	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
12	T	T	PROPN	NNP	Number=Sing	_	_	_	_
13	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
14	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
15	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
16	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
17	AT	AT	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
18	)	)	PUNCT	-RRB-	_	_	_	_	_
19	are	be	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
20	important	important	ADJ	JJ	Degree=Pos	_	_	_	_
21	for	for	ADP	IN	_	_	_	_	_
22	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
23	normal	normal	ADJ	JJ	Degree=Pos	_	_	_	_
24	induction	induction	NOUN	NN	Number=Sing	_	_	_	_
25	of	of	ADP	IN	_	_	_	_	_
26	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
27	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
28	2	2	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
29	,	,	PUNCT	,	_	_	_	_	_
30	it	it	PRON	PRP	Case=Nom|Gender=Neut|Number=Sing|Person=3|PronType=Prs	_	_	_	_
31	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
32	unknown	unknown	ADJ	JJ	Degree=Pos	_	_	_	_
33	if	if	SCONJ	IN	_	_	_	_	_
34	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
35	age	age	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
36	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
37	related	related	ADJ	JJ	Degree=Pos	_	_	_	_
38	decline	decline	NOUN	NN	Number=Sing	_	_	_	_
39	in	in	ADP	IN	_	_	_	_	_
40	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
41	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
42	2	2	NUM	CD	NumType=Card	_	_	_	_
43	production	production	NOUN	NN	Number=Sing	_	_	_	_
44	by	by	ADP	IN	_	_	_	_	_
45	activated	activate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
46	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
47	T	t	PROPN	NNP	Number=Sing	_	_	_	_
48	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
49	may	may	AUX	MD	VerbForm=Fin	_	_	_	_
50	be	be	AUX	VB	VerbForm=Inf	_	_	_	_
51	associated	associate	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
52	with	with	ADP	IN	_	_	_	_	_
53	aberrancies	aberrancy	NOUN	NNS	Number=Plur	_	_	_	_
54	in	in	ADP	IN	_	_	_	_	_
55	transcriptional	transcriptional	ADJ	JJ	Degree=Pos	_	_	_	_
56	regulatory	regulatory	ADJ	JJ	Degree=Pos	_	_	_	_
57	proteins	protein	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
58	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3446
# text = In the current studies, IL-2 production by T cells from elderly (mean 78 years) and young (mean 37 years) humans was measured in cultures stimulated with PHA, PHA plus PMA, crosslinked anti-CD3 mAB OKT3 plus PMA, or PMA plus ionomycin.
1	In	in	ADP	IN	_	_	_	_	_
2	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
3	current	current	ADJ	JJ	Degree=Pos	_	_	_	_
4	studies	study	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
5	,	,	PUNCT	,	_	_	_	_	_
6	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
7	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
8	2	2	NUM	CD	NumType=Card	_	_	_	_
9	production	production	NOUN	NN	Number=Sing	_	_	_	_
10	by	by	ADP	IN	_	_	_	_	_
11	T	t	PROPN	NNP	Number=Sing	_	_	_	_
12	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
13	from	from	ADP	IN	_	_	_	_	_
14	elderly	elderly	ADV	RB	_	_	_	_	_
15	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
16	mean	mean	VERB	VB	VerbForm=Inf	_	_	_	_
17	78	78	NUM	CD	NumType=Card	_	_	_	_
18	years	year	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
19	)	)	PUNCT	-RRB-	_	_	_	_	_
20	and	and	CCONJ	CC	_	_	_	_	_
21	young	young	ADV	RB	_	_	_	_	_
22	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
23	mean	mean	VERB	VB	VerbForm=Inf	_	_	_	_
24	37	37	NUM	CD	NumType=Card	_	_	_	_
25	years	year	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
26	)	)	PUNCT	-RRB-	_	_	_	_	_
27	humans	human	NOUN	NNS	Number=Plur	_	_	_	_
28	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
29	measured	measure	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
30	in	in	ADP	IN	_	_	_	_	_
31	cultures	culture	NOUN	NNS	Number=Plur	_	_	_	_
32	stimulated	stimulate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
33	with	with	ADP	IN	_	_	_	_	_
34	PHA	PHA	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
35	,	,	PUNCT	,	_	_	_	_	_
36	PHA	PHA	PROPN	NNP	Number=Sing	_	_	_	_
37	plus	plus	CCONJ	CC	_	_	_	_	_
38	PMA	PMA	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
39	,	,	PUNCT	,	_	_	_	_	_
40	crosslinked	crosslink	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
41	anti-CD3	anti-CD3	NUM	CD	NumType=Card	_	_	_	_
42	mAB	mab	NOUN	NN	Number=Sing	_	_	_	_
43	OKT3	OKT3	NUM	CD	NumType=Card	_	_	_	_
44	plus	plus	CCONJ	CC	_	_	_	_	_
45	PMA	PMA	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
46	,	,	PUNCT	,	_	_	_	_	_
47	or	or	CCONJ	CC	_	_	_	_	_
48	PMA	PMA	PROPN	NNP	Number=Sing	_	_	_	_
49	plus	plus	CCONJ	CC	_	_	_	_	_
50	ionomycin	ionomycin	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
51	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3447
# text = Substantial decreases of IL-2 production were observed for cell cultures from 7 of 12 elderly individuals in response to the different stimuli, whereas the levels of IL-2 produced by stimulated T cells from other elderly individuals were equivalent to those observed for stimulated T cells of young subjects.
1	Substantial	substantial	ADJ	JJ	Degree=Pos	_	_	_	_
2	decreases	decrease	NOUN	NNS	Number=Plur	_	_	_	_
3	of	of	ADP	IN	_	_	_	_	_
4	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
5	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
6	2	2	NUM	CD	NumType=Card	_	_	_	_
7	production	production	NOUN	NN	Number=Sing	_	_	_	_
8	were	be	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
9	observed	observe	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
10	for	for	ADP	IN	_	_	_	_	_
11	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
12	cultures	culture	NOUN	NNS	Number=Plur	_	_	_	_
13	from	from	ADP	IN	_	_	_	_	_
14	7	7	NUM	CD	NumType=Card	_	_	_	_
15	of	of	ADP	IN	_	_	_	_	_
16	12	12	NUM	CD	NumType=Card	_	_	_	_
17	elderly	elderly	ADJ	JJ	Degree=Pos	_	_	_	_
18	individuals	individual	NOUN	NNS	Number=Plur	_	_	_	_
19	in	in	ADP	IN	_	_	_	_	_
20	response	response	NOUN	NN	Number=Sing	_	_	_	_
21	to	to	ADP	IN	_	_	_	_	_
22	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
23	different	different	ADJ	JJ	Degree=Pos	_	_	_	_
24	stimuli	stimuli	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
25	,	,	PUNCT	,	_	_	_	_	_
26	whereas	whereas	SCONJ	IN	_	_	_	_	_
27	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
28	levels	level	NOUN	NNS	Number=Plur	_	_	_	_
29	of	of	ADP	IN	_	_	_	_	_
30	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
31	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
32	2	2	NUM	CD	NumType=Card	_	_	_	_
33	produced	produce	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
34	by	by	ADP	IN	_	_	_	_	_
35	stimulated	stimulate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
36	T	t	PROPN	NNP	Number=Sing	_	_	_	_
37	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
38	from	from	ADP	IN	_	_	_	_	_
39	other	other	ADJ	JJ	Degree=Pos	_	_	_	_
40	elderly	elderly	ADJ	JJ	Degree=Pos	_	_	_	_
41	individuals	individual	NOUN	NNS	Number=Plur	_	_	_	_
42	were	be	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
43	equivalent	equivalent	ADJ	JJ	Degree=Pos	_	_	_	_
44	to	to	ADP	IN	_	_	_	_	_
45	those	those	PRON	DT	Number=Plur|PronType=Dem	_	_	_	_
46	observed	observe	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
47	for	for	ADP	IN	_	_	_	_	_
48	stimulated	stimulate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
49	T	t	PROPN	NNP	Number=Sing	_	_	_	_
50	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
51	of	of	ADP	IN	_	_	_	_	_
52	young	young	ADJ	JJ	Degree=Pos	_	_	_	_
53	subjects	subjects	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
54	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3448
# text = Analyses of nuclear extracts by electrophoretic DNA mobility shift assays showed that decreased IL-2 production by stimulated T cells of elderly individuals was closely associated with impairments in the activation of both AP-1 and NF-AT.
1	Analyses	analysis	NOUN	NNS	Number=Plur	_	_	_	_
2	of	of	ADP	IN	_	_	_	_	_
3	nuclear	nuclear	ADJ	JJ	Degree=Pos	_	_	_	_
4	extracts	extract	NOUN	NNS	Number=Plur	_	_	_	_
5	by	by	ADP	IN	_	_	_	_	_
6	electrophoretic	electrophoretic	ADJ	JJ	Degree=Pos	_	_	_	_
7	DNA	dna	NOUN	NN	Number=Sing	_	_	_	_
8	mobility	mobility	NOUN	NN	Number=Sing	_	_	_	_
9	shift	shift	NOUN	NN	Number=Sing	_	_	_	_
10	assays	assays	NOUN	NNS	Number=Plur	_	_	_	_
11	showed	show	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
12	that	that	SCONJ	IN	_	_	_	_	_
13	decreased	decrease	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
14	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
15	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
16	2	2	NUM	CD	NumType=Card	_	_	_	_
17	production	production	NOUN	NN	Number=Sing	_	_	_	_
18	by	by	ADP	IN	_	_	_	_	_
19	stimulated	stimulate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
20	T	t	PROPN	NNP	Number=Sing	_	_	_	_
21	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
22	of	of	ADP	IN	_	_	_	_	_
23	elderly	elderly	ADJ	JJ	Degree=Pos	_	_	_	_
24	individuals	individual	NOUN	NNS	Number=Plur	_	_	_	_
25	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
26	closely	closely	ADV	RB	_	_	_	_	_
27	associated	associate	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
28	with	with	ADP	IN	_	_	_	_	_
29	impairments	impairment	NOUN	NNS	Number=Plur	_	_	_	_
30	in	in	ADP	IN	_	_	_	_	_
31	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
32	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
33	of	of	ADP	IN	_	_	_	_	_
34	both	both	DET	DT	_	_	_	_	_
35	AP	ap	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
36	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
37	1	1	NUM	CD	NumType=Card	_	_	_	_
38	and	and	CCONJ	CC	_	_	_	_	_
39	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
40	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
41	AT	at	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
42	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3449
# text = By contrast, T cells from elderly subjects with normal levels of IL-2 production exhibited normal activation of AP-1 and NF-AT.
1	By	by	ADP	IN	_	_	_	_	_
2	contrast	contrast	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
3	,	,	PUNCT	,	_	_	_	_	_
4	T	t	NUM	CD	NumType=Card	_	_	_	_
5	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
6	from	from	ADP	IN	_	_	_	_	_
7	elderly	elderly	ADJ	JJ	Degree=Pos	_	_	_	_
8	subjects	subject	NOUN	NNS	Number=Plur	_	_	_	_
9	with	with	ADP	IN	_	_	_	_	_
10	normal	normal	ADJ	JJ	Degree=Pos	_	_	_	_
11	levels	level	NOUN	NNS	Number=Plur	_	_	_	_
12	of	of	ADP	IN	_	_	_	_	_
13	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
14	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
15	2	2	NUM	CD	NumType=Card	_	_	_	_
16	production	production	NOUN	NN	Number=Sing	_	_	_	_
17	exhibited	exhibit	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
18	normal	normal	ADJ	JJ	Degree=Pos	_	_	_	_
19	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
20	of	of	ADP	IN	_	_	_	_	_
21	AP	Ap	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
22	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
23	1	1	NUM	CD	NumType=Card	_	_	_	_
24	and	and	CCONJ	CC	_	_	_	_	_
25	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
26	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
27	AT	AT	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
28	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3450
# text = In addition, the results of competition experiments analyzing the normal components of NF-AT showed that the age-related reductions in stimulus-dependent NF-AT complexes corresponded to the slow migrating complexes that were composed of c-Fos/c-Jun AP-1.
1	In	in	ADP	IN	_	_	_	_	_
2	addition	addition	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
3	,	,	PUNCT	,	_	_	_	_	_
4	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
5	results	result	NOUN	NNS	Number=Plur	_	_	_	_
6	of	of	ADP	IN	_	_	_	_	_
7	competition	competition	NOUN	NN	Number=Sing	_	_	_	_
8	experiments	experiment	NOUN	NNS	Number=Plur	_	_	_	_
9	analyzing	analyze	VERB	VBG	VerbForm=Ger	_	_	_	_
10	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
11	normal	normal	ADJ	JJ	Degree=Pos	_	_	_	_
12	components	component	NOUN	NNS	Number=Plur	_	_	_	_
13	of	of	ADP	IN	_	_	_	_	_
14	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
15	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
16	AT	AT	PROPN	NNP	Number=Sing	_	_	_	_
17	showed	show	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
18	that	that	SCONJ	IN	_	_	_	_	_
19	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
20	age	age	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
21	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
22	related	related	ADJ	JJ	Degree=Pos	_	_	_	_
23	reductions	reduction	NOUN	NNS	Number=Plur	_	_	_	_
24	in	in	ADP	IN	_	_	_	_	_
25	stimulus	stimulus	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
26	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
27	dependent	dependent	ADJ	JJ	Degree=Pos	_	_	_	_
28	NF	Nf	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
29	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
30	AT	at	PROPN	NNP	Number=Sing	_	_	_	_
31	complexes	complex	NOUN	NNS	Number=Plur	_	_	_	_
32	corresponded	correspond	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
33	to	to	ADP	IN	_	_	_	_	_
34	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
35	slow	slow	ADJ	JJ	Degree=Pos	_	_	_	_
36	migrating	migrating	NOUN	NN	Number=Sing	_	_	_	_
37	complexes	complex	NOUN	NNS	Number=Plur	_	_	_	_
38	that	that	PRON	WDT	PronType=Rel	_	_	_	_
39	were	be	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
40	composed	compose	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
41	of	of	ADP	IN	_	_	_	_	_
42	c-Fos/c	c-Fos/c	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
43	-Jun	-Jun	PROPN	NNP	Number=Sing	_	_	_	_
44	AP	ap	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
45	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
46	1	1	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
47	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3451
# text = The resting and stimulated levels of NF kappa B were reduced in T cells from certain elderly individuals; however, alterations of NF kappa B did not correlate with changes in IL-2 expression.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	resting	resting	NOUN	NN	Number=Sing	_	_	_	_
3	and	and	CCONJ	CC	_	_	_	_	_
4	stimulated	stimulate	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
5	levels	level	NOUN	NNS	Number=Plur	_	_	_	_
6	of	of	ADP	IN	_	_	_	_	_
7	NF	NF	PROPN	NNP	Number=Sing	_	_	_	_
8	kappa	kappa	PROPN	NNP	Number=Sing	_	_	_	_
9	B	b	PROPN	NNP	Number=Sing	_	_	_	_
10	were	be	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
11	reduced	reduce	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
12	in	in	ADP	IN	_	_	_	_	_
13	T	t	PROPN	NNP	Number=Sing	_	_	_	_
14	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
15	from	from	ADP	IN	_	_	_	_	_
16	certain	certain	ADJ	JJ	Degree=Pos	_	_	_	_
17	elderly	elderly	ADJ	JJ	Degree=Pos	_	_	_	_
18	individuals	individual	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
19	;	;	PUNCT	,	_	_	_	_	_
20	however	however	ADV	RB	_	_	_	_	SpaceAfter=No
21	,	,	PUNCT	,	_	_	_	_	_
22	alterations	alteration	NOUN	NNS	Number=Plur	_	_	_	_
23	of	of	ADP	IN	_	_	_	_	_
24	NF	NF	PROPN	NNP	Number=Sing	_	_	_	_
25	kappa	kappa	PROPN	NNP	Number=Sing	_	_	_	_
26	B	B	PROPN	NNP	Number=Sing	_	_	_	_
27	did	do	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
28	not	not	PART	RB	_	_	_	_	_
29	correlate	correlate	VERB	VB	VerbForm=Inf	_	_	_	_
30	with	with	ADP	IN	_	_	_	_	_
31	changes	change	NOUN	NNS	Number=Plur	_	_	_	_
32	in	in	ADP	IN	_	_	_	_	_
33	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
34	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
35	2	2	NUM	CD	NumType=Card	_	_	_	_
36	expression	expression	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
37	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3452
# text = Thus, these results show that age-related impairments in the activation of AP-1 and NF-AT are closely associated with decreased expression of IL-2 and further suggest that aberrancies in the signaling pathways important for the induction of transcriptionally active c-Fos/c-Jun AP-1 may contribute to the impaired activation of NF-AT.
1	Thus	thus	ADV	RB	_	_	_	_	SpaceAfter=No
2	,	,	PUNCT	,	_	_	_	_	_
3	these	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
4	results	result	NOUN	NNS	Number=Plur	_	_	_	_
5	show	show	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
6	that	that	SCONJ	IN	_	_	_	_	_
7	age	age	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
8	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
9	related	related	ADJ	JJ	Degree=Pos	_	_	_	_
10	impairments	impairment	NOUN	NNS	Number=Plur	_	_	_	_
11	in	in	ADP	IN	_	_	_	_	_
12	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
13	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
14	of	of	ADP	IN	_	_	_	_	_
15	AP	Ap	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
16	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
17	1	1	NUM	CD	NumType=Card	_	_	_	_
18	and	and	CCONJ	CC	_	_	_	_	_
19	NF	Nf	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
20	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
21	AT	at	NOUN	NN	Number=Sing	_	_	_	_
22	are	be	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
23	closely	closely	ADV	RB	_	_	_	_	_
24	associated	associate	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
25	with	with	ADP	IN	_	_	_	_	_
26	decreased	decrease	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
27	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
28	of	of	ADP	IN	_	_	_	_	_
29	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
30	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
31	2	2	NUM	CD	NumType=Card	_	_	_	_
32	and	and	CCONJ	CC	_	_	_	_	_
33	further	further	ADV	RB	_	_	_	_	_
34	suggest	suggest	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
35	that	that	SCONJ	IN	_	_	_	_	_
36	aberrancies	aberrancy	NOUN	NNS	Number=Plur	_	_	_	_
37	in	in	ADP	IN	_	_	_	_	_
38	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
39	signaling	signaling	NOUN	NN	Number=Sing	_	_	_	_
40	pathways	pathways	NOUN	NNS	Number=Plur	_	_	_	_
41	important	important	ADJ	JJ	Degree=Pos	_	_	_	_
42	for	for	ADP	IN	_	_	_	_	_
43	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
44	induction	induction	NOUN	NN	Number=Sing	_	_	_	_
45	of	of	ADP	IN	_	_	_	_	_
46	transcriptionally	transcriptionally	ADV	RB	_	_	_	_	_
47	active	active	ADJ	JJ	Degree=Pos	_	_	_	_
48	c-Fos/c	c-Fos/c	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
49	-Jun	-Jun	NOUN	NN	Number=Sing	_	_	_	_
50	AP	ap	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
51	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
52	1	1	NUM	CD	NumType=Card	_	_	_	_
53	may	may	AUX	MD	VerbForm=Fin	_	_	_	_
54	contribute	contribute	VERB	VB	VerbForm=Inf	_	_	_	_
55	to	to	ADP	IN	_	_	_	_	_
56	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
57	impaired	impaire	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
58	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
59	of	of	ADP	IN	_	_	_	_	_
60	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
61	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
62	AT	AT	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
63	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 3453
# text = Document 003003469 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	003003469	003003469	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 3454
# text = Dimerization of NF-KB2 with RelA(p65) regulates DNA binding, transcriptional activation, and inhibition by an I kappa B-alpha (MAD-3).
1	Dimerization	Dimerization	NOUN	NN	Number=Sing	_	_	_	_
2	of	of	ADP	IN	_	_	_	_	_
3	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
4	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
5	KB2	Kb2	NOUN	NN	Number=Sing	_	_	_	_
6	with	with	ADP	IN	_	_	_	_	_
7	RelA	RelA	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
8	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
9	p65	p65	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
10	)	)	PUNCT	-RRB-	_	_	_	_	_
11	regulates	regulate	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
12	DNA	dna	NOUN	NN	Number=Sing	_	_	_	_
13	binding	binding	VERB	VBG	VerbForm=Ger	_	_	_	SpaceAfter=No
14	,	,	PUNCT	,	_	_	_	_	_
15	transcriptional	transcriptional	ADJ	JJ	Degree=Pos	_	_	_	_
16	activation	activation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
17	,	,	PUNCT	,	_	_	_	_	_
18	and	and	CCONJ	CC	_	_	_	_	_
19	inhibition	inhibition	NOUN	NN	Number=Sing	_	_	_	_
20	by	by	ADP	IN	_	_	_	_	_
21	an	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
22	I	I	PRON	PRP	Case=Nom|Number=Sing|Person=1|PronType=Prs	_	_	_	_
23	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_
24	B-	B-	SYM	SYM	_	_	_	_	SpaceAfter=No
25	alpha	alpha	NOUN	NN	Number=Sing	_	_	_	_
26	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
27	MAD	mad	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
28	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
29	3	3	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
30	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
31	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 3455
# text = Inducible expression of human immunodeficiency virus (HIV) is regulated by a cellular transcription factor, nuclear factor kappa B (NF-kappa B).
1	Inducible	Inducible	ADJ	JJ	Degree=Pos	_	_	_	_
2	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
3	of	of	ADP	IN	_	_	_	_	_
4	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
5	immunodeficiency	immunodeficiency	NOUN	NN	Number=Sing	_	_	_	_
6	virus	virus	NOUN	NN	Number=Sing	_	_	_	_
7	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
8	HIV	HIV	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
9	)	)	PUNCT	-RRB-	_	_	_	_	_
10	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
11	regulated	regulate	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
12	by	by	ADP	IN	_	_	_	_	_
13	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
14	cellular	cellular	ADJ	JJ	Degree=Pos	_	_	_	_
15	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
16	factor	factor	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
17	,	,	PUNCT	,	_	_	_	_	_
18	nuclear	nuclear	ADJ	JJ	Degree=Pos	_	_	_	_
19	factor	factor	NOUN	NN	Number=Sing	_	_	_	_
20	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_
21	B	b	NOUN	NN	Number=Sing	_	_	_	_
22	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
23	NF	Nf	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
24	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
25	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_
26	B	b	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
27	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
28	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3456
# text = NF-kappa B is composed of distinct subunits; five independent genes, NFKB1(p105), NFKB2(p100), RelA(p65), c-rel and relB, that encode related proteins that bind to kappa B DNA elements have been isolated.
1	NF	Nf	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
2	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
3	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_
4	B	b	NOUN	NN	Number=Sing	_	_	_	_
5	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
6	composed	compose	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
7	of	of	ADP	IN	_	_	_	_	_
8	distinct	distinct	ADJ	JJ	Degree=Pos	_	_	_	_
9	subunits	subunit	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
10	;	;	PUNCT	,	_	_	_	_	_
11	five	five	NUM	CD	NumType=Card	_	_	_	_
12	independent	independent	ADJ	JJ	Degree=Pos	_	_	_	_
13	genes	gene	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
14	,	,	PUNCT	,	_	_	_	_	_
15	NFKB1	NFKB1	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
16	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
17	p105	p105	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
18	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
19	,	,	PUNCT	,	_	_	_	_	_
20	NFKB2	NFKB2	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
21	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
22	p100	p100	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
23	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
24	,	,	PUNCT	,	_	_	_	_	_
25	RelA	RelA	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
26	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
27	p65	p65	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
28	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
29	,	,	PUNCT	,	_	_	_	_	_
30	c-	c-	SYM	NFP	_	_	_	_	SpaceAfter=No
31	rel	rel	NOUN	NN	Number=Sing	_	_	_	_
32	and	and	CCONJ	CC	_	_	_	_	_
33	relB	relb	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
34	,	,	PUNCT	,	_	_	_	_	_
35	that	that	PRON	WDT	PronType=Rel	_	_	_	_
36	encode	encode	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
37	related	relate	ADJ	JJ	Degree=Pos	_	_	_	_
38	proteins	protein	NOUN	NNS	Number=Plur	_	_	_	_
39	that	that	PRON	WDT	PronType=Rel	_	_	_	_
40	bind	bind	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
41	to	to	ADP	IN	_	_	_	_	_
42	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_
43	B	b	NOUN	NN	Number=Sing	_	_	_	_
44	DNA	dna	NOUN	NN	Number=Sing	_	_	_	_
45	elements	element	NOUN	NNS	Number=Plur	_	_	_	_
46	have	have	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
47	been	be	AUX	VBN	Tense=Past|VerbForm=Part	_	_	_	_
48	isolated	isolate	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	SpaceAfter=No
49	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3457
# text = We have previously found that NFKB2(p49/p52) acts in concert with RelA(p65) to stimulate the HIV enhancer in Jurkat T-leukemia cells.
1	We	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
2	have	have	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
3	previously	previously	ADV	RB	_	_	_	_	_
4	found	find	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
5	that	that	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
6	NFKB2	Nfkb2	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
7	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
8	p49/	p49/	SYM	SYM	_	_	_	_	SpaceAfter=No
9	p52	p52	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
10	)	)	PUNCT	-RRB-	_	_	_	_	_
11	acts	act	NOUN	NNS	Number=Plur	_	_	_	_
12	in	in	ADP	IN	_	_	_	_	_
13	concert	concert	NOUN	NN	Number=Sing	_	_	_	_
14	with	with	ADP	IN	_	_	_	_	_
15	RelA	RelA	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
16	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
17	p65	p65	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
18	)	)	PUNCT	-RRB-	_	_	_	_	_
19	to	to	PART	TO	_	_	_	_	_
20	stimulate	stimulate	VERB	VB	VerbForm=Inf	_	_	_	_
21	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
22	HIV	Hiv	PROPN	NNP	Number=Sing	_	_	_	_
23	enhancer	enhancer	NOUN	NN	Number=Sing	_	_	_	_
24	in	in	ADP	IN	_	_	_	_	_
25	Jurkat	Jurkat	PROPN	NNP	Number=Sing	_	_	_	_
26	T-	T-	PUNCT	,	_	_	_	_	SpaceAfter=No
27	leukemia	leukemia	NOUN	NN	Number=Sing	_	_	_	_
28	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
29	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3458
# text = Here we examine the biochemical basis for the transcriptional regulation of HIV by NFKB2.
1	Here	here	ADV	RB	PronType=Dem	_	_	_	_
2	we	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
3	examine	examine	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
4	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
5	biochemical	biochemical	ADJ	JJ	Degree=Pos	_	_	_	_
6	basis	basis	NOUN	NN	Number=Sing	_	_	_	_
7	for	for	ADP	IN	_	_	_	_	_
8	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
9	transcriptional	transcriptional	ADJ	JJ	Degree=Pos	_	_	_	_
10	regulation	regulation	NOUN	NN	Number=Sing	_	_	_	_
11	of	of	ADP	IN	_	_	_	_	_
12	HIV	HIV	PROPN	NNP	Number=Sing	_	_	_	_
13	by	by	ADP	IN	_	_	_	_	_
14	NFKB2	NFKB2	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
15	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3459
# text = Using Scatchard analysis, we have determined the dissociation constants of homodimeric p49 and heterodimeric p49/p65 for binding to the HIV kappa B site.
1	Using	use	VERB	VBG	VerbForm=Ger	_	_	_	_
2	Scatchard	Scatchard	PROPN	NNP	Number=Sing	_	_	_	_
3	analysis	analysis	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
4	,	,	PUNCT	,	_	_	_	_	_
5	we	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
6	have	have	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
7	determined	determine	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
8	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
9	dissociation	dissociation	NOUN	NN	Number=Sing	_	_	_	_
10	constants	constant	NOUN	NNS	Number=Plur	_	_	_	_
11	of	of	ADP	IN	_	_	_	_	_
12	homodimeric	homodimeric	ADJ	JJ	Degree=Pos	_	_	_	_
13	p49	p49	NOUN	NN	Number=Sing	_	_	_	_
14	and	and	CCONJ	CC	_	_	_	_	_
15	heterodimeric	heterodimeric	ADJ	JJ	Degree=Pos	_	_	_	_
16	p49	p49	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
17	/	/	PUNCT	,	_	_	_	_	SpaceAfter=No
18	p65	p65	NOUN	NN	Number=Sing	_	_	_	_
19	for	for	SCONJ	IN	_	_	_	_	_
20	binding	bind	VERB	VBG	VerbForm=Ger	_	_	_	_
21	to	to	ADP	IN	_	_	_	_	_
22	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
23	HIV	HIV	PROPN	NNP	Number=Sing	_	_	_	_
24	kappa	kappa	PROPN	NNP	Number=Sing	_	_	_	_
25	B	b	PROPN	NNP	Number=Sing	_	_	_	_
26	site	site	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
27	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3460
# text = p49 has a approximately 18-fold-lower affinity for the HIV kappa B site (KD = 69.1 pM)
1	p49	p49	NOUN	NN	Number=Sing	_	_	_	_
2	has	have	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
3	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
4	approximately	approximately	ADV	RB	_	_	_	_	_
5	18	18	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
6	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
7	fold	fold	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
8	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
9	lower	lower	ADJ	JJ	Degree=Pos	_	_	_	_
10	affinity	affinity	NOUN	NN	Number=Sing	_	_	_	_
11	for	for	ADP	IN	_	_	_	_	_
12	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
13	HIV	Hiv	NOUN	NN	Number=Sing	_	_	_	_
14	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_
15	B	b	NOUN	NN	Number=Sing	_	_	_	_
16	site	site	NOUN	NN	Number=Sing	_	_	_	_
17	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
18	KD	kd	NOUN	NN	Number=Sing	_	_	_	_
19	=	=	SYM	SYM	_	_	_	_	_
20	69.1	69.1	NUM	CD	NumType=Card	_	_	_	_
21	pM	pm	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
22	)	)	PUNCT	-RRB-	_	_	_	_	_

# sent_id = 3461
# text = than does the approximately 50-kDa protein NFKB1(p50) derived from p105 (KD = 3.9 pM).
1	than	than	ADP	IN	_	_	_	_	_
2	does	do	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
3	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
4	approximately	approximately	ADV	RB	_	_	_	_	_
5	50	50	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
6	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
7	kDa	kDa	NOUN	NN	Number=Sing	_	_	_	_
8	protein	protein	NOUN	NN	Number=Sing	_	_	_	_
9	NFKB1	NFKB1	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
10	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
11	p50	p50	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
12	)	)	PUNCT	-RRB-	_	_	_	_	_
13	derived	derive	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
14	from	from	ADP	IN	_	_	_	_	_
15	p105	p105	NOUN	NN	Number=Sing	_	_	_	_
16	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
17	KD	kd	NOUN	NN	Number=Sing	_	_	_	_
18	=	=	SYM	SYM	_	_	_	_	_
19	3.9	3.9	NUM	CD	NumType=Card	_	_	_	_
20	pM	pm	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
21	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
22	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3462
# text = In contrast, the affinity of heterodimeric NFKB2(p49)/RelA(p65) for this site is approximately 6-fold higher (KD = 11.8 pM) than that of p49 alone.
1	In	in	ADP	IN	_	_	_	_	_
2	contrast	contrast	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
3	,	,	PUNCT	,	_	_	_	_	_
4	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
5	affinity	affinity	NOUN	NN	Number=Sing	_	_	_	_
6	of	of	ADP	IN	_	_	_	_	_
7	heterodimeric	heterodimeric	ADJ	JJ	Degree=Pos	_	_	_	_
8	NFKB2	Nfkb2	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
9	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
10	p49	p49	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
11	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
12	/	/	PUNCT	,	_	_	_	_	SpaceAfter=No
13	RelA	RelA	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
14	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
15	p65	p65	X	LS	_	_	_	_	SpaceAfter=No
16	)	)	PUNCT	-RRB-	_	_	_	_	_
17	for	for	ADP	IN	_	_	_	_	_
18	this	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
19	site	site	NOUN	NN	Number=Sing	_	_	_	_
20	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
21	approximately	approximately	ADV	RB	_	_	_	_	_
22	6	6	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
23	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
24	fold	fold	NOUN	NN	Number=Sing	_	_	_	_
25	higher	higher	ADJ	JJR	Degree=Cmp	_	_	_	_
26	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
27	KD	K	VERB	VB	Mood=Imp|VerbForm=Fin	_	_	_	_
28	=	=	SYM	SYM	_	_	_	_	_
29	11.8	11.8	NUM	CD	NumType=Card	_	_	_	_
30	pM	pm	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
31	)	)	PUNCT	-RRB-	_	_	_	_	_
32	than	than	ADP	IN	_	_	_	_	_
33	that	that	PRON	DT	Number=Sing|PronType=Dem	_	_	_	_
34	of	of	ADP	IN	_	_	_	_	_
35	p49	p49	NUM	CD	NumType=Card	_	_	_	_
36	alone	alone	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
37	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3463
# text = Consistent with these findings, in vitro transcription was stimulated 18-fold by the addition of preformed, heterodimeric NFKB2(p49)/RelA(p65) protein.
1	Consistent	consistent	ADJ	JJ	Degree=Pos	_	_	_	_
2	with	with	ADP	IN	_	_	_	_	_
3	these	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
4	findings	finding	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
5	,	,	PUNCT	,	_	_	_	_	_
6	in	in	ADP	IN	_	_	_	_	_
7	vitro	vitro	ADJ	JJ	Degree=Pos	_	_	_	_
8	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
9	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
10	stimulated	stimulate	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
11	18	18	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
12	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
13	fold	fold	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
14	by	by	ADP	IN	_	_	_	_	_
15	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
16	addition	addition	NOUN	NN	Number=Sing	_	_	_	_
17	of	of	ADP	IN	_	_	_	_	_
18	preformed	preformed	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	SpaceAfter=No
19	,	,	PUNCT	,	_	_	_	_	_
20	heterodimeric	heterodimeric	ADJ	JJ	Degree=Pos	_	_	_	_
21	NFKB2	Nfkb2	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
22	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
23	p49	p49	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
24	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
25	/	/	PUNCT	,	_	_	_	_	SpaceAfter=No
26	RelA	RelA	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
27	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
28	p65	p65	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
29	)	)	PUNCT	-RRB-	_	_	_	_	_
30	protein	protein	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
31	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3464
# text = Transcriptional activation of the HIV enhancer was also subject to regulation by recently cloned I kappa B-alpha(MAD-3).
1	Transcriptional	Transcriptional	ADJ	JJ	Degree=Pos	_	_	_	_
2	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
3	of	of	ADP	IN	_	_	_	_	_
4	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
5	HIV	HIV	PROPN	NNP	Number=Sing	_	_	_	_
6	enhancer	enhancer	NOUN	NN	Number=Sing	_	_	_	_
7	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
8	also	also	ADV	RB	_	_	_	_	_
9	subject	subject	ADJ	JJ	Degree=Pos	_	_	_	_
10	to	to	PART	TO	_	_	_	_	_
11	regulation	regulation	VERB	VB	VerbForm=Inf	_	_	_	_
12	by	by	ADP	IN	_	_	_	_	_
13	recently	recently	ADV	RB	_	_	_	_	_
14	cloned	clon	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
15	I	I	PRON	PRP	Case=Nom|Number=Sing|Person=1|PronType=Prs	_	_	_	_
16	kappa	kappa	X	GW	_	_	_	_	_
17	B-	B-	X	GW	_	_	_	_	SpaceAfter=No
18	alpha	alpha	X	GW	_	_	_	_	SpaceAfter=No
19	(	(	X	GW	_	_	_	_	SpaceAfter=No
20	MAD	mad	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
21	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
22	3	3	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
23	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
24	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3465
# text = Recombinant
1	Recombinant	Recombinant	NOUN	NN	Number=Sing	_	_	_	_

# sent_id = 3466
# text = I kappa B-alpha(MAD-3) inhibited the DNA binding activity of p65, p49/p65, and p50/p65 but stimulated the binding of NFKB2(p49) or NFKB1(p50).
1	I	I	PRON	PRP	Case=Nom|Number=Sing|Person=1|PronType=Prs	_	_	_	_
2	kappa	kappa	X	FW	Foreign=Yes	_	_	_	_
3	B	b	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
4	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
5	alpha	alpha	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
6	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
7	MAD	mad	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
8	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
9	3	3	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
10	)	)	PUNCT	-RRB-	_	_	_	_	_
11	inhibited	inhibit	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
12	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
13	DNA	dna	NOUN	NN	Number=Sing	_	_	_	_
14	binding	binde	VERB	VBG	VerbForm=Ger	_	_	_	_
15	activity	activity	NOUN	NN	Number=Sing	_	_	_	_
16	of	of	ADP	IN	_	_	_	_	_
17	p65	p65	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
18	,	,	PUNCT	,	_	_	_	_	_
19	p49/	p49/	ADP	IN	Abbr=Yes	_	_	_	SpaceAfter=No
20	p65	p65	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
21	,	,	PUNCT	,	_	_	_	_	_
22	and	and	CCONJ	CC	_	_	_	_	_
23	p50	p50	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
24	/	/	PUNCT	,	_	_	_	_	SpaceAfter=No
25	p65	p65	NOUN	NN	Number=Sing	_	_	_	_
26	but	but	CCONJ	CC	_	_	_	_	_
27	stimulated	stimulate	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
28	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
29	binding	binding	NOUN	NN	Number=Sing	_	_	_	_
30	of	of	ADP	IN	_	_	_	_	_
31	NFKB2	NFKB2	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
32	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
33	p49	p49	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
34	)	)	PUNCT	-RRB-	_	_	_	_	_
35	or	or	CCONJ	CC	_	_	_	_	_
36	NFKB1	NFKB1	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
37	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
38	p50	p50	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
39	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
40	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3467
# text = Functional activation of an HIV reporter plasmid by p49/p65 in transiently transfected Jurkat T-leukemia cells was also inhibited by coexpression of MAD-3.
1	Functional	functional	ADJ	JJ	Degree=Pos	_	_	_	_
2	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
3	of	of	ADP	IN	_	_	_	_	_
4	an	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
5	HIV	HIV	PROPN	NNP	Number=Sing	_	_	_	_
6	reporter	reporter	NOUN	NN	Number=Sing	_	_	_	_
7	plasmid	plasmid	NOUN	NN	Number=Sing	_	_	_	_
8	by	by	ADP	IN	_	_	_	_	_
9	p49	p49	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
10	/	/	PUNCT	,	_	_	_	_	SpaceAfter=No
11	p65	p65	NOUN	NN	Number=Sing	_	_	_	_
12	in	in	ADP	IN	_	_	_	_	_
13	transiently	transiently	ADV	RB	_	_	_	_	_
14	transfected	transfect	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
15	Jurkat	Jurkat	PROPN	NNP	Number=Sing	_	_	_	_
16	T-	T-	SYM	NFP	_	_	_	_	SpaceAfter=No
17	leukemia	leukemia	NOUN	NN	Number=Sing	_	_	_	_
18	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
19	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
20	also	also	ADV	RB	_	_	_	_	_
21	inhibited	inhibit	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
22	by	by	ADP	IN	_	_	_	_	_
23	coexpression	coexpression	NOUN	NN	Number=Sing	_	_	_	_
24	of	of	ADP	IN	_	_	_	_	_
25	MAD	mad	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
26	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
27	3	3	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
28	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3468
# text = (ABSTRACT TRUNCATED AT 250 WORDS)
1	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
2	ABSTRACT	ABSTRACT	X	GW	_	_	_	_	_
3	TRUNCATED	Truncate	VERB	VB	Mood=Imp|VerbForm=Fin	_	_	_	_
4	AT	at	ADV	RB	_	_	_	_	_
5	250	250	NUM	CD	NumType=Card	_	_	_	_
6	WORDS	words	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
7	)	)	PUNCT	-RRB-	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 3469
# text = Document 003003471 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	003003471	003003471	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 3470
# text = Interferon-alpha induction of STATs1, -3 DNA binding and growth arrest is independent of Lck and active mitogen-activated kinase in T cells.
1	Interferon	Interferon	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
2	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
3	alpha	alpha	X	FW	Foreign=Yes	_	_	_	_
4	induction	induction	NOUN	NN	Number=Sing	_	_	_	_
5	of	of	ADP	IN	_	_	_	_	_
6	STATs1	STATs1	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
7	,	,	PUNCT	,	_	_	_	_	_
8	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
9	3	3	NUM	CD	NumType=Card	_	_	_	_
10	DNA	dna	NOUN	NN	Number=Sing	_	_	_	_
11	binding	binding	VERB	VBG	VerbForm=Ger	_	_	_	_
12	and	and	CCONJ	CC	_	_	_	_	_
13	growth	growth	NOUN	NN	Number=Sing	_	_	_	_
14	arrest	arrest	NOUN	NN	Number=Sing	_	_	_	_
15	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
16	independent	independent	ADJ	JJ	Degree=Pos	_	_	_	_
17	of	of	ADP	IN	_	_	_	_	_
18	Lck	Lck	PROPN	NNP	Number=Sing	_	_	_	_
19	and	and	CCONJ	CC	_	_	_	_	_
20	active	active	ADJ	JJ	Degree=Pos	_	_	_	_
21	mitogen	mitogen	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
22	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
23	activated	activate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
24	kinase	kinase	NOUN	NN	Number=Sing	_	_	_	_
25	in	in	ADP	IN	_	_	_	_	_
26	T	t	PROPN	NNP	Number=Sing	_	_	_	_
27	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
28	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 3471
# text = Type I interferons (IFNs) are a family of cytokines that have antiviral and antiproliferative effects.
1	Type	type	NOUN	NN	Number=Sing	_	_	_	_
2	I	I	PRON	PRP	Case=Nom|Number=Sing|Person=1|PronType=Prs	_	_	_	_
3	interferons	interferon	NOUN	NNS	Number=Plur	_	_	_	_
4	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
5	IFNs	IFN	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
6	)	)	PUNCT	-RRB-	_	_	_	_	_
7	are	be	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
8	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
9	family	family	NOUN	NN	Number=Sing	_	_	_	_
10	of	of	ADP	IN	_	_	_	_	_
11	cytokines	cytokine	NOUN	NNS	Number=Plur	_	_	_	_
12	that	that	PRON	WDT	PronType=Rel	_	_	_	_
13	have	have	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
14	antiviral	antiviral	ADJ	JJ	Degree=Pos	_	_	_	_
15	and	and	CCONJ	CC	_	_	_	_	_
16	antiproliferative	antiproliferative	ADJ	JJ	Degree=Pos	_	_	_	_
17	effects	effect	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
18	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3472
# text = Data regarding the processes by which these cytokines transduce signals from the cell membrane to the nucleus are becoming increasingly complex.
1	Data	data	PROPN	NNP	Number=Sing	_	_	_	_
2	regarding	regard	VERB	VBG	VerbForm=Ger	_	_	_	_
3	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
4	processes	process	NOUN	NNS	Number=Plur	_	_	_	_
5	by	by	ADP	IN	_	_	_	_	_
6	which	which	PRON	WDT	PronType=Rel	_	_	_	_
7	these	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
8	cytokines	cytokine	NOUN	NNS	Number=Plur	_	_	_	_
9	transduce	transduce	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
10	signals	signal	NOUN	NNS	Number=Plur	_	_	_	_
11	from	from	ADP	IN	_	_	_	_	_
12	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
13	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
14	membrane	membrane	NOUN	NN	Number=Sing	_	_	_	_
15	to	to	ADP	IN	_	_	_	_	_
16	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
17	nucleus	nucleus	NOUN	NN	Number=Sing	_	_	_	_
18	are	be	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
19	becoming	become	VERB	VBG	Tense=Pres|VerbForm=Part	_	_	_	_
20	increasingly	increasingly	ADV	RB	_	_	_	_	_
21	complex	complex	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
22	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3473
# text = The most characterized pathway is via JAK-STAT signaling.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	most	most	ADV	RBS	_	_	_	_	_
3	characterized	characterize	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
4	pathway	pathway	NOUN	NN	Number=Sing	_	_	_	_
5	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
6	via	via	ADP	IN	_	_	_	_	_
7	JAK	JAK	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
8	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
9	STAT	Stat	PROPN	NNP	Number=Sing	_	_	_	_
10	signaling	signaling	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
11	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3474
# text = Previous studies established a potential role for the Src-family kinase Lck in JAK-STAT signaling.
1	Previous	previous	ADJ	JJ	Degree=Pos	_	_	_	_
2	studies	study	NOUN	NNS	Number=Plur	_	_	_	_
3	established	establish	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
4	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
5	potential	potential	ADJ	JJ	Degree=Pos	_	_	_	_
6	role	role	NOUN	NN	Number=Sing	_	_	_	_
7	for	for	ADP	IN	_	_	_	_	_
8	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
9	Src-	src-	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
10	family	family	NOUN	NN	Number=Sing	_	_	_	_
11	kinase	kinase	NOUN	NN	Number=Sing	_	_	_	_
12	Lck	Lck	PROPN	NNP	Number=Sing	_	_	_	_
13	in	in	ADP	IN	_	_	_	_	_
14	JAK	JAK	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
15	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
16	STAT	STAT	PROPN	NNP	Number=Sing	_	_	_	_
17	signaling	signaling	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
18	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3475
# text = Therefore, this study was designed to analyze the role of Lck in IFN-alpha signaling by using the Jurkat, JCam (an Lck-defective cell line derived from Jurkat), and JCam/Lck (JCam cells with Lck restored).
1	Therefore	therefore	ADV	RB	_	_	_	_	SpaceAfter=No
2	,	,	PUNCT	,	_	_	_	_	_
3	this	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
4	study	study	NOUN	NN	Number=Sing	_	_	_	_
5	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
6	designed	design	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
7	to	to	PART	TO	_	_	_	_	_
8	analyze	analyze	VERB	VB	VerbForm=Inf	_	_	_	_
9	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
10	role	role	NOUN	NN	Number=Sing	_	_	_	_
11	of	of	ADP	IN	_	_	_	_	_
12	Lck	Lck	PROPN	NNP	Number=Sing	_	_	_	_
13	in	in	ADP	IN	_	_	_	_	_
14	IFN	IFN	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
15	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
16	alpha	alpha	NOUN	NN	Number=Sing	_	_	_	_
17	signaling	signal	VERB	VBG	VerbForm=Ger	_	_	_	_
18	by	by	SCONJ	IN	_	_	_	_	_
19	using	use	VERB	VBG	VerbForm=Ger	_	_	_	_
20	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
21	Jurkat	Jurkat	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
22	,	,	PUNCT	,	_	_	_	_	_
23	JCam	JCam	PROPN	NNP	Number=Sing	_	_	_	_
24	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
25	an	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
26	Lck-defective	Lck-defective	ADJ	JJ	Degree=Pos	_	_	_	_
27	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
28	line	line	NOUN	NN	Number=Sing	_	_	_	_
29	derived	derive	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
30	from	from	ADP	IN	_	_	_	_	_
31	Jurkat	Jurkat	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
32	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
33	,	,	PUNCT	,	_	_	_	_	_
34	and	and	CCONJ	CC	_	_	_	_	_
35	JC	JC	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
36	am	be	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
37	/	/	PUNCT	,	_	_	_	_	SpaceAfter=No
38	Lck	Lck	PROPN	NNP	Number=Sing	_	_	_	_
39	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
40	JCam	JCam	PROPN	NNP	Number=Sing	_	_	_	_
41	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
42	with	with	ADP	IN	_	_	_	_	_
43	Lck	Lck	PROPN	NNP	Number=Sing	_	_	_	_
44	restored	restore	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	SpaceAfter=No
45	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
46	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3476
# text = The results show that IFN-alpha can induce MAPK activity, but only in cells containing Lck. Furthermore, STATs1 and -3 are effectively phosphorylated and activated to bind DNA in the absence of Lck expression in IFN-alpha-treated cells.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	results	result	NOUN	NNS	Number=Plur	_	_	_	_
3	show	show	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
4	that	that	SCONJ	IN	_	_	_	_	_
5	IFN	IFN	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
6	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
7	alpha	alpha	NOUN	NN	Number=Sing	_	_	_	_
8	can	can	AUX	MD	VerbForm=Fin	_	_	_	_
9	induce	induce	VERB	VB	VerbForm=Inf	_	_	_	_
10	MAPK	MAPK	PROPN	NNP	Number=Sing	_	_	_	_
11	activity	activity	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
12	,	,	PUNCT	,	_	_	_	_	_
13	but	but	CCONJ	CC	_	_	_	_	_
14	only	only	ADV	RB	_	_	_	_	_
15	in	in	ADP	IN	_	_	_	_	_
16	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
17	containing	contain	VERB	VBG	VerbForm=Ger	_	_	_	_
18	Lck.	Lck.	PROPN	NNP	Number=Sing	_	_	_	_
19	Furthermore	Furthermore	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
20	,	,	PUNCT	,	_	_	_	_	_
21	STATs1	STATs1	PROPN	NNP	Number=Sing	_	_	_	_
22	and	and	CCONJ	CC	_	_	_	_	_
23	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
24	3	3	X	LS	_	_	_	_	_
25	are	be	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
26	effectively	effectively	ADV	RB	_	_	_	_	_
27	phosphorylated	phosphorylated	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
28	and	and	CCONJ	CC	_	_	_	_	_
29	activated	activate	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
30	to	to	PART	TO	_	_	_	_	_
31	bind	bind	VERB	VB	VerbForm=Inf	_	_	_	_
32	DNA	dna	NOUN	NN	Number=Sing	_	_	_	_
33	in	in	ADP	IN	_	_	_	_	_
34	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
35	absence	absence	NOUN	NN	Number=Sing	_	_	_	_
36	of	of	ADP	IN	_	_	_	_	_
37	Lck	Lck	PROPN	NNP	Number=Sing	_	_	_	_
38	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
39	in	in	ADP	IN	_	_	_	_	_
40	IFN	IFN	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
41	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
42	alpha	alpha	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
43	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
44	treated	treat	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
45	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
46	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3477
# text = Finally, the results demonstrate that IFN-alpha exerts an antiproliferative effect in all three cell lines.
1	Finally	finally	ADV	RB	_	_	_	_	SpaceAfter=No
2	,	,	PUNCT	,	_	_	_	_	_
3	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
4	results	result	NOUN	NNS	Number=Plur	_	_	_	_
5	demonstrate	demonstrate	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
6	that	that	SCONJ	IN	_	_	_	_	_
7	IFN	Ifn	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
8	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
9	alpha	alpha	NOUN	NN	Number=Sing	_	_	_	_
10	exerts	exert	NOUN	NNS	Number=Plur	_	_	_	_
11	an	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
12	antiproliferative	antiproliferative	ADJ	JJ	Degree=Pos	_	_	_	_
13	effect	effect	NOUN	NN	Number=Sing	_	_	_	_
14	in	in	ADP	IN	_	_	_	_	_
15	all	all	DET	DT	_	_	_	_	_
16	three	three	NUM	CD	NumType=Card	_	_	_	_
17	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
18	lines	line	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
19	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3478
# text = These data indicate that Lck and active MAPK do not affect IFN-alpha-induced growth arrest or induction of STAT1s1 and -3 DNA binding ability.
1	These	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
2	data	data	NOUN	NN	Number=Sing	_	_	_	_
3	indicate	indicate	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
4	that	that	SCONJ	IN	_	_	_	_	_
5	Lck	Lck	PROPN	NNP	Number=Sing	_	_	_	_
6	and	and	CCONJ	CC	_	_	_	_	_
7	active	active	ADJ	JJ	Degree=Pos	_	_	_	_
8	MAPK	Mapk	PROPN	NNP	Number=Sing	_	_	_	_
9	do	do	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
10	not	not	PART	RB	_	_	_	_	_
11	affect	affect	VERB	VB	VerbForm=Inf	_	_	_	_
12	IFN	Ifn	ADV	RB	_	_	_	_	SpaceAfter=No
13	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
14	alpha-induced	alpha-induced	ADJ	JJ	Degree=Pos	_	_	_	_
15	growth	growth	NOUN	NN	Number=Sing	_	_	_	_
16	arrest	arrest	NOUN	NN	Number=Sing	_	_	_	_
17	or	or	CCONJ	CC	_	_	_	_	_
18	induction	induction	NOUN	NN	Number=Sing	_	_	_	_
19	of	of	ADP	IN	_	_	_	_	_
20	STAT1s1	STAT1s1	NOUN	NN	Number=Sing	_	_	_	_
21	and	and	CCONJ	CC	_	_	_	_	_
22	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
23	3	3	NUM	CD	NumType=Card	_	_	_	_
24	DNA	dna	NOUN	NN	Number=Sing	_	_	_	_
25	binding	binding	VERB	VBG	VerbForm=Ger	_	_	_	_
26	ability	ability	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
27	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3479
# text = Copyright 1999 Academic Press.
1	Copyright	copyright	NOUN	NN	Number=Sing	_	_	_	_
2	1999	1999	NUM	CD	NumType=Card	_	_	_	_
3	Academic	academic	PROPN	NNP	Number=Sing	_	_	_	_
4	Press.	Press.	PROPN	NNP	Number=Sing	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 3480
# text = Document 003003473 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	003003473	003003473	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 3481
# text = Evidence for a polyclonal etiology of palmar fibromatosis.
1	Evidence	evidence	NOUN	NN	Number=Sing	_	_	_	_
2	for	for	ADP	IN	_	_	_	_	_
3	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
4	polyclonal	polyclonal	ADJ	JJ	Degree=Pos	_	_	_	_
5	etiology	etiology	NOUN	NN	Number=Sing	_	_	_	_
6	of	of	ADP	IN	_	_	_	_	_
7	palmar	palmar	NOUN	NN	Number=Sing	_	_	_	_
8	fibromatosis	fibromatosis	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
9	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 3482
# text = X chromosome inactivation patterns at the androgen receptor locus were evaluated to determine clonality in microdissected lesional tissue and in leukocytes from 2 women with Dupuytren's disease.
1	X	x	ADP	IN	_	_	_	_	_
2	chromosome	chromosome	DET	DT	_	_	_	_	_
3	inactivation	inactivation	NOUN	NN	Number=Sing	_	_	_	_
4	patterns	pattern	NOUN	NNS	Number=Plur	_	_	_	_
5	at	at	ADP	IN	_	_	_	_	_
6	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
7	androgen	androgen	ADJ	JJ	Degree=Pos	_	_	_	_
8	receptor	receptor	NOUN	NN	Number=Sing	_	_	_	_
9	locus	locus	NOUN	NN	Number=Sing	_	_	_	_
10	were	be	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
11	evaluated	evaluate	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
12	to	to	PART	TO	_	_	_	_	_
13	determine	determine	VERB	VB	VerbForm=Inf	_	_	_	_
14	clonality	clonality	NOUN	NN	Number=Sing	_	_	_	_
15	in	in	ADP	IN	_	_	_	_	_
16	microdissected	microdissect	ADJ	JJ	Degree=Pos	_	_	_	_
17	lesional	lesional	ADJ	JJ	Degree=Pos	_	_	_	_
18	tissue	tissue	NOUN	NN	Number=Sing	_	_	_	_
19	and	and	CCONJ	CC	_	_	_	_	_
20	in	in	ADP	IN	_	_	_	_	_
21	leukocytes	leukocyte	NOUN	NNS	Number=Plur	_	_	_	_
22	from	from	ADP	IN	_	_	_	_	_
23	2	2	NUM	CD	NumType=Card	_	_	_	_
24	women	woman	NOUN	NNS	Number=Plur	_	_	_	_
25	with	with	ADP	IN	_	_	_	_	_
26	Dupuytren	Dupuytren	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
27	's	's	PART	POS	_	_	_	_	_
28	disease	disease	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
29	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3483
# text = The tissue from both patients generated a polyclonal pattern of X chromosome inactivation of the human androgen receptor gene.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	tissue	tissue	NOUN	NN	Number=Sing	_	_	_	_
3	from	from	ADP	IN	_	_	_	_	_
4	both	both	DET	DT	_	_	_	_	_
5	patients	patient	NOUN	NN	Number=Sing	_	_	_	_
6	generated	generate	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
7	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
8	polyclonal	polyclonal	ADJ	JJ	Degree=Pos	_	_	_	_
9	pattern	pattern	NOUN	NN	Number=Sing	_	_	_	_
10	of	of	ADP	IN	_	_	_	_	_
11	X	x	ADJ	JJ	Degree=Pos	_	_	_	_
12	chromosome	chromosome	NOUN	NN	Number=Sing	_	_	_	_
13	inactivation	inactivation	NOUN	NN	Number=Sing	_	_	_	_
14	of	of	ADP	IN	_	_	_	_	_
15	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
16	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
17	androgen	androgen	NOUN	NN	Number=Sing	_	_	_	_
18	receptor	receptor	NOUN	NN	Number=Sing	_	_	_	_
19	gene	gene	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
20	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3484
# text = This finding supports a polyclonal reactive process as the underlying etiology for palmar fibromatosis.
1	This	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
2	finding	finding	NOUN	NN	Number=Sing	_	_	_	_
3	supports	support	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
4	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
5	polyclonal	polyclonal	ADJ	JJ	Degree=Pos	_	_	_	_
6	reactive	reactive	ADJ	JJ	Degree=Pos	_	_	_	_
7	process	process	NOUN	NN	Number=Sing	_	_	_	_
8	as	as	SCONJ	IN	_	_	_	_	_
9	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
10	underlying	underly	ADJ	JJ	Degree=Pos	_	_	_	_
11	etiology	etiology	NOUN	NN	Number=Sing	_	_	_	_
12	for	for	ADP	IN	_	_	_	_	_
13	palmar	palmar	NOUN	NN	Number=Sing	_	_	_	_
14	fibromatosis	fibromatosis	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
15	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 3485
# text = Document 003003476 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	003003476	003003476	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 3486
# text = Comparative analysis identifies conserved tumor necrosis factor receptor-associated factor 3 binding sites in the human and simian Epstein-Barr virus oncogene LMP1.
1	Comparative	Comparative	ADJ	JJ	Degree=Pos	_	_	_	_
2	analysis	analysis	NOUN	NN	Number=Sing	_	_	_	_
3	identifies	identify	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
4	conserved	conserve	ADJ	JJ	Degree=Pos	_	_	_	_
5	tumor	tumor	NOUN	NN	Number=Sing	_	_	_	_
6	necrosis	necrosis	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
7	factor	factor	NOUN	NN	Number=Sing	_	_	_	_
8	receptor	receptor	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
9	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
10	associated	associate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
11	factor	factor	NOUN	NN	Number=Sing	_	_	_	_
12	3	3	NUM	CD	NumType=Card	_	_	_	_
13	binding	binding	VERB	VBG	VerbForm=Ger	_	_	_	_
14	sites	site	NOUN	NNS	Number=Plur	_	_	_	_
15	in	in	ADP	IN	_	_	_	_	_
16	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
17	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
18	and	and	CCONJ	CC	_	_	_	_	_
19	simian	simian	ADJ	JJ	Degree=Pos	_	_	_	_
20	Epstein	Epstein	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
21	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
22	Barr	Barr	PROPN	NNP	Number=Sing	_	_	_	_
23	virus	virus	NOUN	NN	Number=Sing	_	_	_	_
24	oncogene	oncogene	PROPN	NNP	Number=Sing	_	_	_	_
25	LMP1	Lmp1	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
26	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 3487
# text = Nonhuman primates are naturally infected with a B-lymphotropic herpesvirus closely related to Epstein-Barr virus (EBV).
1	Nonhuman	Nonhuman	ADJ	JJ	Degree=Pos	_	_	_	_
2	primates	primate	NOUN	NNS	Number=Plur	_	_	_	_
3	are	be	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
4	naturally	naturally	ADV	RB	_	_	_	_	_
5	infected	infect	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
6	with	with	ADP	IN	_	_	_	_	_
7	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
8	B	b	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
9	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
10	lymphotropic	lymphotropic	NOUN	NN	Number=Sing	_	_	_	_
11	herpesvirus	herpesvirus	NOUN	NN	Number=Sing	_	_	_	_
12	closely	closely	ADV	RB	_	_	_	_	_
13	related	related	ADJ	JJ	Degree=Pos	_	_	_	_
14	to	to	ADP	IN	_	_	_	_	_
15	Epstein	Epstein	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
16	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
17	Barr	Barr	PROPN	NNP	Number=Sing	_	_	_	_
18	virus	virus	NOUN	NN	Number=Sing	_	_	_	_
19	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
20	EBV	EBV	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
21	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
22	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3488
# text = These simian EBV share considerable genetic, biologic, and epidemiologic features with human EBV, including virus-induced tumorigenesis.
1	These	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
2	simian	simian	ADJ	JJ	Degree=Pos	_	_	_	_
3	EBV	EBV	PROPN	NNP	Number=Sing	_	_	_	_
4	share	share	NOUN	NN	Number=Sing	_	_	_	_
5	considerable	considerable	ADJ	JJ	Degree=Pos	_	_	_	_
6	genetic	genetic	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
7	,	,	PUNCT	,	_	_	_	_	_
8	biologic	biologic	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
9	,	,	PUNCT	,	_	_	_	_	_
10	and	and	CCONJ	CC	_	_	_	_	_
11	epidemiologic	epidemiologic	ADJ	JJ	Degree=Pos	_	_	_	_
12	features	feature	NOUN	NNS	Number=Plur	_	_	_	_
13	with	with	ADP	IN	_	_	_	_	_
14	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
15	EBV	EBV	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
16	,	,	PUNCT	,	_	_	_	_	_
17	including	include	VERB	VBG	VerbForm=Ger	_	_	_	_
18	virus	virus	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
19	-induced	-induced	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
20	tumorigenesis	tumorigenesis	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
21	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3489
# text = However, latent, transformation-associated viral genes demonstrate marked sequence divergence among species despite the conserved functions.
1	However	however	ADV	RB	_	_	_	_	SpaceAfter=No
2	,	,	PUNCT	,	_	_	_	_	_
3	latent	latent	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
4	,	,	PUNCT	,	_	_	_	_	_
5	transformation	transformation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
6	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
7	associated	associate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
8	viral	viral	ADJ	JJ	Degree=Pos	_	_	_	_
9	genes	gene	NOUN	NNS	Number=Plur	_	_	_	_
10	demonstrate	demonstrate	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
11	marked	mark	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
12	sequence	sequence	NOUN	NN	Number=Sing	_	_	_	_
13	divergence	divergence	NOUN	NN	Number=Sing	_	_	_	_
14	among	among	ADP	IN	_	_	_	_	_
15	species	species	NOUN	NNS	Number=Plur	_	_	_	_
16	despite	despite	ADP	IN	_	_	_	_	_
17	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
18	conserved	conserve	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
19	functions	function	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
20	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3490
# text = We have cloned the latent membrane protein 1 (LMP1) homologs from the simian EBV naturally infecting baboons (cercopithicine herpesvirus 12, herpesvirus papio) and rhesus monkeys (cercopithicine herpesvirus 15) for a comparative study with the human EBV oncogene.
1	We	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
2	have	have	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
3	cloned	clon	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
4	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
5	latent	latent	ADJ	JJ	Degree=Pos	_	_	_	_
6	membrane	membrane	NOUN	NN	Number=Sing	_	_	_	_
7	protein	protein	NOUN	NN	Number=Sing	_	_	_	_
8	1	1	NUM	CD	NumType=Card	_	_	_	_
9	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
10	LMP1	Lmp1	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
11	)	)	PUNCT	-RRB-	_	_	_	_	_
12	homologs	homolog	NOUN	NNS	Number=Plur	_	_	_	_
13	from	from	ADP	IN	_	_	_	_	_
14	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
15	simian	simian	ADJ	JJ	Degree=Pos	_	_	_	_
16	EBV	EBV	PROPN	NNP	Number=Sing	_	_	_	_
17	naturally	naturally	ADV	RB	_	_	_	_	_
18	infecting	infecte	VERB	VBG	VerbForm=Ger	_	_	_	_
19	baboons	baboon	NOUN	NNS	Number=Plur	_	_	_	_
20	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
21	cercopithicine	cercopithicine	NOUN	NN	Number=Sing	_	_	_	_
22	herpesvirus	herpesvirus	NOUN	NN	Number=Sing	_	_	_	_
23	12	12	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
24	,	,	PUNCT	,	_	_	_	_	_
25	herpesvirus	herpesvirus	NOUN	NN	Number=Sing	_	_	_	_
26	papio	papio	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
27	)	)	PUNCT	-RRB-	_	_	_	_	_
28	and	and	CCONJ	CC	_	_	_	_	_
29	rhesus	rhesus	ADJ	JJ	Degree=Pos	_	_	_	_
30	monkeys	monkey	NOUN	NNS	Number=Plur	_	_	_	_
31	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
32	cercopithicine	cercopithicine	NOUN	NN	Number=Sing	_	_	_	_
33	herpesvirus	herpesvirus	NOUN	NN	Number=Sing	_	_	_	_
34	15	15	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
35	)	)	PUNCT	-RRB-	_	_	_	_	_
36	for	for	ADP	IN	_	_	_	_	_
37	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
38	comparative	comparative	ADJ	JJ	Degree=Pos	_	_	_	_
39	study	study	NOUN	NN	Number=Sing	_	_	_	_
40	with	with	ADP	IN	_	_	_	_	_
41	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
42	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
43	EBV	EBV	PROPN	NNP	Number=Sing	_	_	_	_
44	oncogene	oncogene	ADV	RB	_	_	_	_	SpaceAfter=No
45	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3491
# text = The transmembrane domains are well conserved, but there is striking sequence divergence of the carboxy-terminal cytoplasmic domain essential for B-cell immortalization and interaction with the tumor necrosis factor receptor signaling pathway.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	transmembrane	transmembrane	NOUN	NN	Number=Sing	_	_	_	_
3	domains	domain	NOUN	NNS	Number=Plur	_	_	_	_
4	are	be	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
5	well	well	ADV	RB	Degree=Pos	_	_	_	_
6	conserved	conserve	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	SpaceAfter=No
7	,	,	PUNCT	,	_	_	_	_	_
8	but	but	CCONJ	CC	_	_	_	_	_
9	there	there	PRON	EX	_	_	_	_	_
10	is	be	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
11	striking	strik	VERB	VBG	VerbForm=Ger	_	_	_	_
12	sequence	sequence	NOUN	NN	Number=Sing	_	_	_	_
13	divergence	divergence	NOUN	NN	Number=Sing	_	_	_	_
14	of	of	ADP	IN	_	_	_	_	_
15	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
16	carboxy	carboxy	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
17	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
18	terminal	terminal	ADJ	JJ	Degree=Pos	_	_	_	_
19	cytoplasmic	cytoplasmic	ADJ	JJ	Degree=Pos	_	_	_	_
20	domain	domain	NOUN	NN	Number=Sing	_	_	_	_
21	essential	essential	ADJ	JJ	Degree=Pos	_	_	_	_
22	for	for	ADP	IN	_	_	_	_	_
23	B	b	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
24	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
25	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
26	immortalization	immortalization	NOUN	NN	Number=Sing	_	_	_	_
27	and	and	CCONJ	CC	_	_	_	_	_
28	interaction	interaction	NOUN	NN	Number=Sing	_	_	_	_
29	with	with	ADP	IN	_	_	_	_	_
30	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
31	tumor	tumor	NOUN	NN	Number=Sing	_	_	_	_
32	necrosis	necrosis	NOUN	NN	Number=Sing	_	_	_	_
33	factor	factor	NOUN	NN	Number=Sing	_	_	_	_
34	receptor	receptor	NOUN	NN	Number=Sing	_	_	_	_
35	signaling	signale	VERB	VBG	VerbForm=Ger	_	_	_	_
36	pathway	pathway	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
37	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3492
# text = Nevertheless, the simian EBV LMP1s retain most functions in common with EBV LMP1, including the ability to induce NF-(kappa)B activity in human cells, to bind the tumor necrosis factor-associated factor 3 (TRAF3) in vitro, and to induce expression of tumor necrosis factor-responsive genes, such as ICAM1, in human B lymphocytes.
1	Nevertheless	nevertheless	ADV	RB	_	_	_	_	SpaceAfter=No
2	,	,	PUNCT	,	_	_	_	_	_
3	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
4	simian	simian	ADJ	JJ	Degree=Pos	_	_	_	_
5	EBV	EBV	PROPN	NNP	Number=Sing	_	_	_	_
6	LMP	LMP	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
7	1s	1	NOUN	NNS	Number=Plur	_	_	_	_
8	retain	retain	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
9	most	most	ADJ	JJS	Degree=Sup	_	_	_	_
10	functions	function	NOUN	NNS	Number=Plur	_	_	_	_
11	in	in	ADP	IN	_	_	_	_	_
12	common	common	ADJ	JJ	Degree=Pos	_	_	_	_
13	with	with	ADP	IN	_	_	_	_	_
14	EBV	EBV	PROPN	NNP	Number=Sing	_	_	_	_
15	LMP1	LMP1	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
16	,	,	PUNCT	,	_	_	_	_	_
17	including	include	VERB	VBG	VerbForm=Ger	_	_	_	_
18	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
19	ability	ability	NOUN	NN	Number=Sing	_	_	_	_
20	to	to	PART	TO	_	_	_	_	_
21	induce	induce	VERB	VB	VerbForm=Inf	_	_	_	_
22	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
23	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
24	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
25	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
26	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
27	B	b	ADJ	JJ	Degree=Pos	_	_	_	_
28	activity	activity	NOUN	NN	Number=Sing	_	_	_	_
29	in	in	ADP	IN	_	_	_	_	_
30	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
31	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
32	,	,	PUNCT	,	_	_	_	_	_
33	to	to	PART	TO	_	_	_	_	_
34	bind	bind	VERB	VB	VerbForm=Inf	_	_	_	_
35	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
36	tumor	tumor	NOUN	NN	Number=Sing	_	_	_	_
37	necrosis	necrosis	NOUN	NN	Number=Sing	_	_	_	_
38	factor	factor	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
39	-associated	-associate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
40	factor	factor	NOUN	NN	Number=Sing	_	_	_	_
41	3	3	NUM	CD	NumType=Card	_	_	_	_
42	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
43	TRAF3	TRAF3	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
44	)	)	PUNCT	-RRB-	_	_	_	_	_
45	in	in	ADP	IN	_	_	_	_	_
46	vitro	vitro	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
47	,	,	PUNCT	,	_	_	_	_	_
48	and	and	CCONJ	CC	_	_	_	_	_
49	to	to	PART	TO	_	_	_	_	_
50	induce	induce	VERB	VB	VerbForm=Inf	_	_	_	_
51	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
52	of	of	ADP	IN	_	_	_	_	_
53	tumor	tumor	NOUN	NN	Number=Sing	_	_	_	_
54	necrosis	necrosis	NOUN	NN	Number=Sing	_	_	_	_
55	factor	factor	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
56	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
57	responsive	responsive	ADJ	JJ	Degree=Pos	_	_	_	_
58	genes	gene	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
59	,	,	PUNCT	,	_	_	_	_	_
60	such	such	ADJ	JJ	Degree=Pos	_	_	_	_
61	as	as	ADP	IN	_	_	_	_	_
62	ICAM1	ICAM1	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
63	,	,	PUNCT	,	_	_	_	_	_
64	in	in	ADP	IN	_	_	_	_	_
65	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
66	B	b	NOUN	NN	Number=Sing	_	_	_	_
67	lymphocytes	lymphocyte	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
68	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3493
# text = Multiple TRAF3 binding sites containing a PXQXT/S core sequence can be identified in the simian EBV LMP1s by an in vitro binding assay.
1	Multiple	multiple	ADJ	JJ	Degree=Pos	_	_	_	_
2	TRAF3	TRAF3	NOUN	NN	Number=Sing	_	_	_	_
3	binding	bind	VERB	VBG	VerbForm=Ger	_	_	_	_
4	sites	site	NOUN	NNS	Number=Plur	_	_	_	_
5	containing	contain	VERB	VBG	VerbForm=Ger	_	_	_	_
6	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
7	PXQXT/	Pxqxt/	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
8	S	's	PART	POS	_	_	_	_	_
9	core	core	NOUN	NN	Number=Sing	_	_	_	_
10	sequence	sequence	NOUN	NN	Number=Sing	_	_	_	_
11	can	can	AUX	MD	VerbForm=Fin	_	_	_	_
12	be	be	AUX	VB	VerbForm=Inf	_	_	_	_
13	identified	identify	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
14	in	in	ADP	IN	_	_	_	_	_
15	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
16	simian	simian	ADJ	JJ	Degree=Pos	_	_	_	_
17	EBV	EBV	PROPN	NNP	Number=Sing	_	_	_	_
18	LMP	LMP	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
19	1s	1	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
20	by	by	ADP	IN	_	_	_	_	_
21	an	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
22	in	in	ADP	IN	_	_	_	_	_
23	vitro	vitro	NOUN	NN	Number=Sing	_	_	_	_
24	binding	binding	VERB	VBG	VerbForm=Ger	_	_	_	_
25	assay	assay	ADV	RB	_	_	_	_	SpaceAfter=No
26	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3494
# text = A PXQXT/S-containing sequence is also present in the cytoplasmic domain of the Hodgkin's disease marker, CD30, and binds TRAF3 in vitro.
1	A	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
2	PXQXT/S	pxqxt/s	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
3	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
4	containing	containing	VERB	VBG	VerbForm=Ger	_	_	_	_
5	sequence	sequence	NOUN	NN	Number=Sing	_	_	_	_
6	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
7	also	also	ADV	RB	_	_	_	_	_
8	present	present	ADJ	JJ	Degree=Pos	_	_	_	_
9	in	in	ADP	IN	_	_	_	_	_
10	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
11	cytoplasmic	cytoplasmic	ADJ	JJ	Degree=Pos	_	_	_	_
12	domain	domain	NOUN	NN	Number=Sing	_	_	_	_
13	of	of	ADP	IN	_	_	_	_	_
14	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
15	Hodgkin	Hodgkin	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
16	's	's	PART	POS	_	_	_	_	_
17	disease	disease	NOUN	NN	Number=Sing	_	_	_	_
18	marker	marker	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
19	,	,	PUNCT	,	_	_	_	_	_
20	CD30	CD30	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
21	,	,	PUNCT	,	_	_	_	_	_
22	and	and	CCONJ	CC	_	_	_	_	_
23	binds	bind	NOUN	NNS	Number=Plur	_	_	_	_
24	TRAF3	TRAF3	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
25	in	in	ADP	IN	_	_	_	_	_
26	vitro	vitro	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
27	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3495
# text = The last 13 amino acids containing a PXQXT/S sequence are highly conserved in human and simian EBV LMP1 but do not bind TRAF3, suggesting a distinct role for this conserved region of LMP1.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	last	last	ADJ	JJ	Degree=Pos	_	_	_	_
3	13	13	NUM	CD	NumType=Card	_	_	_	_
4	amino	amino	NOUN	NN	Number=Sing	_	_	_	_
5	acids	acid	SCONJ	IN	_	_	_	_	_
6	containing	contain	VERB	VBG	VerbForm=Ger	_	_	_	_
7	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
8	PXQXT/	Pxqxt/	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
9	S	's	PART	POS	_	_	_	_	_
10	sequence	sequence	NOUN	NN	Number=Sing	_	_	_	_
11	are	be	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
12	highly	highly	ADV	RB	_	_	_	_	_
13	conserved	conserve	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
14	in	in	ADP	IN	_	_	_	_	_
15	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
16	and	and	CCONJ	CC	_	_	_	_	_
17	simian	simian	ADJ	JJ	Degree=Pos	_	_	_	_
18	EBV	EBV	PROPN	NNP	Number=Sing	_	_	_	_
19	LMP1	LMP1	PROPN	NNP	Number=Sing	_	_	_	_
20	but	but	CCONJ	CC	_	_	_	_	_
21	do	do	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
22	not	not	PART	RB	_	_	_	_	_
23	bind	bind	VERB	VB	VerbForm=Inf	_	_	_	_
24	TRAF3	TRAF3	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
25	,	,	PUNCT	,	_	_	_	_	_
26	suggesting	suggest	VERB	VBG	VerbForm=Ger	_	_	_	_
27	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
28	distinct	distinct	ADJ	JJ	Degree=Pos	_	_	_	_
29	role	role	NOUN	NN	Number=Sing	_	_	_	_
30	for	for	ADP	IN	_	_	_	_	_
31	this	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
32	conserved	conserved	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
33	region	region	NOUN	NN	Number=Sing	_	_	_	_
34	of	of	ADP	IN	_	_	_	_	_
35	LMP1	LMP1	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
36	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3496
# text = The conserved TRAF3 binding sites in LMP1 and the CD30 Hodgkin's disease marker provides further evidence that a TRAF3-mediated signal transduction pathway may be important in malignant transformation.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	conserved	conserve	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
3	TRAF3	TRAF3	NOUN	NN	Number=Sing	_	_	_	_
4	binding	binding	VERB	VBG	VerbForm=Ger	_	_	_	_
5	sites	site	NOUN	NNS	Number=Plur	_	_	_	_
6	in	in	ADP	IN	_	_	_	_	_
7	LMP1	LMP1	PROPN	NNP	Number=Sing	_	_	_	_
8	and	and	CCONJ	CC	_	_	_	_	_
9	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
10	CD30	CD30	PROPN	NNP	Number=Sing	_	_	_	_
11	Hodgkin	Hodgkin	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
12	's	's	PART	POS	_	_	_	_	_
13	disease	disease	NOUN	NN	Number=Sing	_	_	_	_
14	marker	marker	NOUN	NN	Number=Sing	_	_	_	_
15	provides	provide	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
16	further	further	ADJ	JJ	Degree=Pos	_	_	_	_
17	evidence	evidence	NOUN	NN	Number=Sing	_	_	_	_
18	that	that	PRON	WDT	PronType=Rel	_	_	_	_
19	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
20	TRAF3	TRAF3	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
21	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
22	mediated	mediate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
23	signal	signal	NOUN	NN	Number=Sing	_	_	_	_
24	transduction	transduction	NOUN	NN	Number=Sing	_	_	_	_
25	pathway	pathway	NOUN	NN	Number=Sing	_	_	_	_
26	may	may	AUX	MD	VerbForm=Fin	_	_	_	_
27	be	be	AUX	VB	VerbForm=Inf	_	_	_	_
28	important	important	ADJ	JJ	Degree=Pos	_	_	_	_
29	in	in	ADP	IN	_	_	_	_	_
30	malignant	malignant	ADJ	JJ	Degree=Pos	_	_	_	_
31	transformation	transformation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
32	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 3497
# text = Document 003003478 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	003003478	003003478	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 3498
# text = Overexpression of DR-nm23, a protein encoded by a member of the nm23 gene family, inhibits granulocyte differentiation and induces apoptosis in 32Dc13 myeloid cells.
1	Overexpression	Overexpression	NOUN	NN	Number=Sing	_	_	_	_
2	of	of	ADP	IN	_	_	_	_	_
3	DR-	dr-	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
4	nm23	nm23	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
5	,	,	PUNCT	,	_	_	_	_	_
6	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
7	protein	protein	NOUN	NN	Number=Sing	_	_	_	_
8	encoded	encod	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
9	by	by	ADP	IN	_	_	_	_	_
10	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
11	member	member	NOUN	NN	Number=Sing	_	_	_	_
12	of	of	ADP	IN	_	_	_	_	_
13	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
14	nm23	nm23	NOUN	NN	Number=Sing	_	_	_	_
15	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
16	family	family	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
17	,	,	PUNCT	,	_	_	_	_	_
18	inhibits	inhibits	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
19	granulocyte	granulocyte	ADJ	JJ	Degree=Pos	_	_	_	_
20	differentiation	differentiation	NOUN	NN	Number=Sing	_	_	_	_
21	and	and	CCONJ	CC	_	_	_	_	_
22	induces	induce	NOUN	NNS	Number=Plur	_	_	_	_
23	apoptosis	apoptosis	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
24	in	in	ADP	IN	_	_	_	_	_
25	32Dc13	32Dc13	NUM	CD	NumType=Card	_	_	_	_
26	myeloid	myeloid	ADJ	JJ	Degree=Pos	_	_	_	_
27	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
28	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 3499
# text = Chronic myelogenous leukemia evolves in two clinically distinct stages: a chronic and a blast crisis phase.
1	Chronic	Chronic	ADJ	JJ	Degree=Pos	_	_	_	_
2	myelogenous	myelogenous	ADJ	JJ	Degree=Pos	_	_	_	_
3	leukemia	leukemia	NOUN	NN	Number=Sing	_	_	_	_
4	evolves	evolve	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
5	in	in	ADP	IN	_	_	_	_	_
6	two	two	NUM	CD	NumType=Card	_	_	_	_
7	clinically	clinically	ADV	RB	_	_	_	_	_
8	distinct	distinct	ADJ	JJ	Degree=Pos	_	_	_	_
9	stages	stage	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
10	:	:	PUNCT	:	_	_	_	_	_
11	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
12	chronic	chronic	NOUN	NN	Number=Sing	_	_	_	_
13	and	and	CCONJ	CC	_	_	_	_	_
14	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
15	blast	blast	ADJ	JJ	Degree=Pos	_	_	_	_
16	crisis	crisis	NOUN	NN	Number=Sing	_	_	_	_
17	phase	phase	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
18	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3500
# text = The molecular changes associated with chronic phase to blast crisis transition are largely unknown.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	molecular	molecular	ADJ	JJ	Degree=Pos	_	_	_	_
3	changes	change	NOUN	NNS	Number=Plur	_	_	_	_
4	associated	associate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
5	with	with	ADP	IN	_	_	_	_	_
6	chronic	chronic	ADJ	JJ	Degree=Pos	_	_	_	_
7	phase	phase	NOUN	NN	Number=Sing	_	_	_	_
8	to	to	PART	TO	_	_	_	_	_
9	blast	blast	VERB	VB	VerbForm=Inf	_	_	_	_
10	crisis	crisis	NOUN	NN	Number=Sing	_	_	_	_
11	transition	transition	NOUN	NN	Number=Sing	_	_	_	_
12	are	be	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
13	largely	largely	ADV	RB	_	_	_	_	_
14	unknown	unknown	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
15	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3501
# text = We have identified a cDNA clone, DR-nm23, differentially expressed in a blast-crisis cDNA library, which has approximately 70% sequence similarity to the putative metastatic suppressor genes, nm23-H1 and nm23-H2.
1	We	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
2	have	have	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
3	identified	identify	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
4	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
5	cDNA	cDNa	NOUN	NN	Number=Sing	_	_	_	_
6	clone	clone	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
7	,	,	PUNCT	,	_	_	_	_	_
8	DR-	dr-	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
9	nm23	nm23	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
10	,	,	PUNCT	,	_	_	_	_	_
11	differentially	differentially	ADV	RB	_	_	_	_	_
12	expressed	express	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
13	in	in	ADP	IN	_	_	_	_	_
14	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
15	blast	blast	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
16	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
17	crisis	crisis	NOUN	NN	Number=Sing	_	_	_	_
18	cDNA	cDNa	NOUN	NN	Number=Sing	_	_	_	_
19	library	library	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
20	,	,	PUNCT	,	_	_	_	_	_
21	which	which	PRON	WDT	PronType=Rel	_	_	_	_
22	has	have	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
23	approximately	approximately	ADV	RB	_	_	_	_	_
24	70	70	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
25	%	%	SYM	NN	Number=Sing	_	_	_	_
26	sequence	sequence	NOUN	NN	Number=Sing	_	_	_	_
27	similarity	similarity	NOUN	NN	Number=Sing	_	_	_	_
28	to	to	ADP	IN	_	_	_	_	_
29	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
30	putative	putative	ADJ	JJ	Degree=Pos	_	_	_	_
31	metastatic	metastatic	ADJ	JJ	Degree=Pos	_	_	_	_
32	suppressor	suppressor	NOUN	NN	Number=Sing	_	_	_	_
33	genes	gene	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
34	,	,	PUNCT	,	_	_	_	_	_
35	nm23	nm23	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
36	-	-	SYM	SYM	_	_	_	_	SpaceAfter=No
37	H1	H1	NUM	CD	NumType=Card	_	_	_	_
38	and	and	CCONJ	CC	_	_	_	_	_
39	nm23	nm23	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
40	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
41	H2	H2	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
42	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3502
# text = The deduced amino acid sequence similarity to the proteins encoded by these two latter genes is approximately 65% and includes domains and amino acid residues (the leucine zipper-like and the RGD domain, a serine and a histidine residue in the NH2- and in the COOH-terminal portion of the protein, respectively) postulated to be important for nm23 function.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	deduced	deduce	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
3	amino	amino	DET	DT	_	_	_	_	_
4	acid	acid	ADJ	JJ	Degree=Pos	_	_	_	_
5	sequence	sequence	NOUN	NN	Number=Sing	_	_	_	_
6	similarity	similarity	NOUN	NN	Number=Sing	_	_	_	_
7	to	to	ADP	IN	_	_	_	_	_
8	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
9	proteins	protein	NOUN	NNS	Number=Plur	_	_	_	_
10	encoded	encod	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
11	by	by	ADP	IN	_	_	_	_	_
12	these	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
13	two	two	NUM	CD	NumType=Card	_	_	_	_
14	latter	latter	ADJ	JJ	Degree=Pos	_	_	_	_
15	genes	gene	NOUN	NNS	Number=Plur	_	_	_	_
16	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
17	approximately	approximately	ADV	RB	_	_	_	_	_
18	65	65	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
19	%	%	SYM	NN	Number=Sing	_	_	_	_
20	and	and	CCONJ	CC	_	_	_	_	_
21	includes	include	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
22	domains	domain	NOUN	NNS	Number=Plur	_	_	_	_
23	and	and	CCONJ	CC	_	_	_	_	_
24	amino	amino	DET	DT	_	_	_	_	_
25	acid	acid	ADJ	JJ	Degree=Pos	_	_	_	_
26	residues	residue	NOUN	NNS	Number=Plur	_	_	_	_
27	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
28	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
29	leucine	leucine	NOUN	NN	Number=Sing	_	_	_	_
30	zipper	zipper	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
31	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
32	like	like	ADJ	JJ	Degree=Pos	_	_	_	_
33	and	and	CCONJ	CC	_	_	_	_	_
34	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
35	RGD	RGD	ADJ	JJ	Degree=Pos	_	_	_	_
36	domain	domain	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
37	,	,	PUNCT	,	_	_	_	_	_
38	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
39	serine	serine	NOUN	NN	Number=Sing	_	_	_	_
40	and	and	CCONJ	CC	_	_	_	_	_
41	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
42	histidine	histidine	NOUN	NN	Number=Sing	_	_	_	_
43	residue	residue	NOUN	NN	Number=Sing	_	_	_	_
44	in	in	ADP	IN	_	_	_	_	_
45	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
46	NH2	Nh2	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
47	-	-	PUNCT	,	_	_	_	_	_
48	and	and	CCONJ	CC	_	_	_	_	_
49	in	in	ADP	IN	_	_	_	_	_
50	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
51	COOH	COOh	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
52	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
53	terminal	terminal	ADJ	JJ	Degree=Pos	_	_	_	_
54	portion	portion	NOUN	NN	Number=Sing	_	_	_	_
55	of	of	ADP	IN	_	_	_	_	_
56	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
57	protein	protein	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
58	,	,	PUNCT	,	_	_	_	_	_
59	respectively	respectively	ADV	RB	_	_	_	_	SpaceAfter=No
60	)	)	PUNCT	-RRB-	_	_	_	_	_
61	postulated	postulate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
62	to	to	PART	TO	_	_	_	_	_
63	be	be	AUX	VB	VerbForm=Inf	_	_	_	_
64	important	important	ADJ	JJ	Degree=Pos	_	_	_	_
65	for	for	ADP	IN	_	_	_	_	_
66	nm23	nm23	NUM	CD	NumType=Card	_	_	_	_
67	function	function	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
68	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3503
# text = DR-nm23 mRNA is preferentially expressed at early stages of myeloid differentiation of highly purified CD34+ cells.
1	DR-	DR-	SYM	NFP	_	_	_	_	SpaceAfter=No
2	nm23	nm23	NUM	CD	NumType=Card	_	_	_	_
3	mRNA	mRNa	PROPN	NNP	Number=Sing	_	_	_	_
4	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
5	preferentially	preferentially	ADV	RB	_	_	_	_	_
6	expressed	express	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
7	at	at	ADP	IN	_	_	_	_	_
8	early	early	ADJ	JJ	Degree=Pos	_	_	_	_
9	stages	stage	NOUN	NNS	Number=Plur	_	_	_	_
10	of	of	ADP	IN	_	_	_	_	_
11	myeloid	myeloid	ADJ	JJ	Degree=Pos	_	_	_	_
12	differentiation	differentiation	NOUN	NN	Number=Sing	_	_	_	_
13	of	of	ADP	IN	_	_	_	_	_
14	highly	highly	ADV	RB	_	_	_	_	_
15	purified	purified	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
16	CD34	CD34	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
17	+	+	SYM	SYM	_	_	_	_	_
18	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
19	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3504
# text = Its constitutive expression in the myeloid precursor 32Dc13 cell line, which is growth-factor dependent for both proliferation and differentiation, results in inhibition of granulocytic differentiation induced by granulocyte colony-stimulating factor and causes apoptotic cell death.
1	Its	its	PRON	PRP$	Gender=Neut|Number=Sing|Person=3|Poss=Yes|PronType=Prs	_	_	_	_
2	constitutive	constitutive	ADJ	JJ	Degree=Pos	_	_	_	_
3	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
4	in	in	ADP	IN	_	_	_	_	_
5	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
6	myeloid	myeloid	ADJ	JJ	Degree=Pos	_	_	_	_
7	precursor	precursor	NOUN	NN	Number=Sing	_	_	_	_
8	32Dc13	32Dc13	NUM	CD	NumType=Card	_	_	_	_
9	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
10	line	line	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
11	,	,	PUNCT	,	_	_	_	_	_
12	which	which	PRON	WDT	PronType=Rel	_	_	_	_
13	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
14	growth	growth	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
15	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
16	factor	factor	NOUN	NN	Number=Sing	_	_	_	_
17	dependent	dependent	ADJ	JJ	Degree=Pos	_	_	_	_
18	for	for	ADP	IN	_	_	_	_	_
19	both	both	DET	DT	_	_	_	_	_
20	proliferation	proliferation	NOUN	NN	Number=Sing	_	_	_	_
21	and	and	CCONJ	CC	_	_	_	_	_
22	differentiation	differentiation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
23	,	,	PUNCT	,	_	_	_	_	_
24	results	result	NOUN	NNS	Number=Plur	_	_	_	_
25	in	in	ADP	IN	_	_	_	_	_
26	inhibition	inhibition	NOUN	NN	Number=Sing	_	_	_	_
27	of	of	ADP	IN	_	_	_	_	_
28	granulocytic	granulocytic	ADJ	JJ	Degree=Pos	_	_	_	_
29	differentiation	differentiation	NOUN	NN	Number=Sing	_	_	_	_
30	induced	induce	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
31	by	by	ADP	IN	_	_	_	_	_
32	granulocyte	granulocyte	NOUN	NN	Number=Sing	_	_	_	_
33	colony	colony	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
34	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
35	stimulating	stimulating	NOUN	NN	Number=Sing	_	_	_	_
36	factor	factor	NOUN	NN	Number=Sing	_	_	_	_
37	and	and	CCONJ	CC	_	_	_	_	_
38	causes	cause	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
39	apoptotic	apoptotic	ADJ	JJ	Degree=Pos	_	_	_	_
40	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
41	death	death	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
42	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3505
# text = These results are consistent with a role for DR-nm23 in normal hematopoiesis and raise the possibility that its overexpression contributes to differentiation arrest, a feature of blastic transformation in chronic myelogenous leukemia.
1	These	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
2	results	result	NOUN	NNS	Number=Plur	_	_	_	_
3	are	be	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
4	consistent	consistent	ADJ	JJ	Degree=Pos	_	_	_	_
5	with	with	ADP	IN	_	_	_	_	_
6	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
7	role	role	NOUN	NN	Number=Sing	_	_	_	_
8	for	for	ADP	IN	_	_	_	_	_
9	DR-	DR-	SYM	NFP	_	_	_	_	SpaceAfter=No
10	nm23	nm23	NUM	CD	NumType=Card	_	_	_	_
11	in	in	ADP	IN	_	_	_	_	_
12	normal	normal	ADJ	JJ	Degree=Pos	_	_	_	_
13	hematopoiesis	hematopoiesis	NOUN	NN	Number=Sing	_	_	_	_
14	and	and	CCONJ	CC	_	_	_	_	_
15	raise	raise	VERB	VB	VerbForm=Inf	_	_	_	_
16	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
17	possibility	possibility	NOUN	NN	Number=Sing	_	_	_	_
18	that	that	SCONJ	IN	_	_	_	_	_
19	its	its	PRON	PRP$	Gender=Neut|Number=Sing|Person=3|Poss=Yes|PronType=Prs	_	_	_	_
20	overexpression	overexpression	NOUN	NN	Number=Sing	_	_	_	_
21	contributes	contribute	NOUN	NNS	Number=Plur	_	_	_	_
22	to	to	ADP	IN	_	_	_	_	_
23	differentiation	differentiation	NOUN	NN	Number=Sing	_	_	_	_
24	arrest	arrest	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
25	,	,	PUNCT	,	_	_	_	_	_
26	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
27	feature	feature	NOUN	NN	Number=Sing	_	_	_	_
28	of	of	ADP	IN	_	_	_	_	_
29	blastic	blastic	ADJ	JJ	Degree=Pos	_	_	_	_
30	transformation	transformation	NOUN	NN	Number=Sing	_	_	_	_
31	in	in	ADP	IN	_	_	_	_	_
32	chronic	chronic	ADJ	JJ	Degree=Pos	_	_	_	_
33	myelogenous	myelogenous	ADJ	JJ	Degree=Pos	_	_	_	_
34	leukemia	leukemia	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
35	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 3506
# text = Document 003003481 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	003003481	003003481	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 3507
# text = Induction of ICAM-1 and LFA-3 by Tax1 of human T-cell leukemia virus type 1 and mechanism of down-regulation of ICAM-1 or LFA-1 in adult-T-cell-leukemia cell lines.
1	Induction	Induction	NOUN	NN	Number=Sing	_	_	_	_
2	of	of	ADP	IN	_	_	_	_	_
3	ICAM	ICAM	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
4	-	-	SYM	SYM	_	_	_	_	SpaceAfter=No
5	1	1	NUM	CD	NumType=Card	_	_	_	_
6	and	and	CCONJ	CC	_	_	_	_	_
7	LFA	LFa	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
8	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
9	3	3	NUM	CD	NumType=Card	_	_	_	_
10	by	by	ADP	IN	_	_	_	_	_
11	Tax1	Tax1	NUM	CD	NumType=Card	_	_	_	_
12	of	of	ADP	IN	_	_	_	_	_
13	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
14	T-	t-	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
15	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
16	leukemia	leukemia	NOUN	NN	Number=Sing	_	_	_	_
17	virus	virus	NOUN	NN	Number=Sing	_	_	_	_
18	type	type	NOUN	NN	Number=Sing	_	_	_	_
19	1	1	NUM	CD	NumType=Card	_	_	_	_
20	and	and	CCONJ	CC	_	_	_	_	_
21	mechanism	mechanism	NOUN	NN	Number=Sing	_	_	_	_
22	of	of	ADP	IN	_	_	_	_	_
23	down	down	ADV	RB	_	_	_	_	SpaceAfter=No
24	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
25	regulation	regulation	NOUN	NN	Number=Sing	_	_	_	_
26	of	of	ADP	IN	_	_	_	_	_
27	ICAM	ICAm	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
28	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
29	1	1	NUM	CD	NumType=Card	_	_	_	_
30	or	or	CCONJ	CC	_	_	_	_	_
31	LFA	LFa	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
32	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
33	1	1	NUM	CD	NumType=Card	_	_	_	_
34	in	in	ADP	IN	_	_	_	_	_
35	adult	adult	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
36	-T-cell	-T-cell	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
37	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
38	leukemia	leukemia	NOUN	NN	Number=Sing	_	_	_	_
39	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
40	lines	line	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
41	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 3508
# text = The present study was undertaken to determine the role of HTLV-I TaxI in the up-regulation of ICAM-I and LFA-3 in human T cells transformed with HTLV-I and the mechanism of down-regulation of ICAM-I and LFA-I in ATL-derived cell lines.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	present	present	ADJ	JJ	Degree=Pos	_	_	_	_
3	study	study	NOUN	NN	Number=Sing	_	_	_	_
4	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
5	undertaken	undertaken	ADJ	JJ	Degree=Pos	_	_	_	_
6	to	to	PART	TO	_	_	_	_	_
7	determine	determine	VERB	VB	VerbForm=Inf	_	_	_	_
8	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
9	role	role	NOUN	NN	Number=Sing	_	_	_	_
10	of	of	ADP	IN	_	_	_	_	_
11	HTLV	HTLV	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
12	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
13	I	I	PRON	PRP	Case=Nom|Number=Sing|Person=1|PronType=Prs	_	_	_	_
14	TaxI	taxi	PROPN	NNP	Number=Sing	_	_	_	_
15	in	in	ADP	IN	_	_	_	_	_
16	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
17	up	up	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
18	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
19	regulation	regulation	NOUN	NN	Number=Sing	_	_	_	_
20	of	of	ADP	IN	_	_	_	_	_
21	ICAM	ICAm	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
22	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
23	I	I	PRON	PRP	Case=Nom|Number=Sing|Person=1|PronType=Prs	_	_	_	_
24	and	and	CCONJ	CC	_	_	_	_	_
25	LFA	LFA	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
26	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
27	3	3	NUM	CD	NumType=Card	_	_	_	_
28	in	in	ADP	IN	_	_	_	_	_
29	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
30	T	t	PROPN	NNP	Number=Sing	_	_	_	_
31	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
32	transformed	transform	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
33	with	with	ADP	IN	_	_	_	_	_
34	HTLV	HTLV	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
35	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
36	I	I	PRON	PRP	Case=Nom|Number=Sing|Person=1|PronType=Prs	_	_	_	_
37	and	and	CCONJ	CC	_	_	_	_	_
38	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
39	mechanism	mechanism	NOUN	NN	Number=Sing	_	_	_	_
40	of	of	ADP	IN	_	_	_	_	_
41	down	down	ADV	RB	_	_	_	_	SpaceAfter=No
42	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
43	regulation	regulation	NOUN	NN	Number=Sing	_	_	_	_
44	of	of	ADP	IN	_	_	_	_	_
45	ICAM	ICAM	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
46	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
47	I	I	PRON	PRP	Case=Nom|Number=Sing|Person=1|PronType=Prs	_	_	_	_
48	and	and	CCONJ	CC	_	_	_	_	_
49	LFA	LFA	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
50	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
51	I	I	PRON	PRP	Case=Nom|Number=Sing|Person=1|PronType=Prs	_	_	_	_
52	in	in	ADP	IN	_	_	_	_	_
53	ATL	ATL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
54	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
55	derived	derive	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
56	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
57	lines	line	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
58	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3509
# text = Induction of TaxI in a human T-cell line Jurkat carrying the TaxI gene under the metallothionein promoter led to increases in mRNA and surface expression of ICAM-I.
1	Induction	Induction	NOUN	NN	Number=Sing	_	_	_	_
2	of	of	ADP	IN	_	_	_	_	_
3	TaxI	taxi	PROPN	NNP	Number=Sing	_	_	_	_
4	in	in	ADP	IN	_	_	_	_	_
5	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
6	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
7	T-	t-	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
8	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
9	line	line	NOUN	NN	Number=Sing	_	_	_	_
10	Jurkat	Jurkat	SCONJ	IN	_	_	_	_	_
11	carrying	carry	VERB	VBG	VerbForm=Ger	_	_	_	_
12	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
13	TaxI	taxi	PROPN	NNP	Number=Sing	_	_	_	_
14	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
15	under	under	ADP	IN	_	_	_	_	_
16	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
17	metallothionein	metallothionein	NOUN	NN	Number=Sing	_	_	_	_
18	promoter	promoter	NOUN	NN	Number=Sing	_	_	_	_
19	led	lead	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
20	to	to	ADP	IN	_	_	_	_	_
21	increases	increase	NOUN	NNS	Number=Plur	_	_	_	_
22	in	in	ADP	IN	_	_	_	_	_
23	mRNA	mRNa	NOUN	NN	Number=Sing	_	_	_	_
24	and	and	CCONJ	CC	_	_	_	_	_
25	surface	surface	NOUN	NN	Number=Sing	_	_	_	_
26	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
27	of	of	ADP	IN	_	_	_	_	_
28	ICAM	ICAm	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
29	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
30	I	I	PRON	PRP	Case=Nom|Number=Sing|Person=1|PronType=Prs	_	_	_	SpaceAfter=No
31	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3510
# text = The response of LFA-3 to TaxI induction was, on the other hand, relatively slow and weak, and might be indirect.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	response	response	NOUN	NN	Number=Sing	_	_	_	_
3	of	of	ADP	IN	_	_	_	_	_
4	LFA	LFA	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
5	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
6	3	3	NUM	CD	NumType=Card	_	_	_	_
7	to	to	ADP	IN	_	_	_	_	_
8	TaxI	taxi	PROPN	NNP	Number=Sing	_	_	_	_
9	induction	induction	NOUN	NN	Number=Sing	_	_	_	_
10	was	be	VERB	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	SpaceAfter=No
11	,	,	PUNCT	,	_	_	_	_	_
12	on	on	ADP	IN	_	_	_	_	_
13	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
14	other	other	ADJ	JJ	Degree=Pos	_	_	_	_
15	hand	hand	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
16	,	,	PUNCT	,	_	_	_	_	_
17	relatively	relatively	ADV	RB	_	_	_	_	_
18	slow	slow	ADJ	JJ	Degree=Pos	_	_	_	_
19	and	and	CCONJ	CC	_	_	_	_	_
20	weak	weak	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
21	,	,	PUNCT	,	_	_	_	_	_
22	and	and	CCONJ	CC	_	_	_	_	_
23	might	might	AUX	MD	VerbForm=Fin	_	_	_	_
24	be	be	AUX	VB	VerbForm=Inf	_	_	_	_
25	indirect	indirect	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
26	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3511
# text = Transactivation of the ICAM-I promoter by TaxI was further shown by co-transfection of a CAT reporter construct with the ICAM-I promoter and a plasmid expressing TaxI.
1	Transactivation	Transactivation	NOUN	NN	Number=Sing	_	_	_	_
2	of	of	ADP	IN	_	_	_	_	_
3	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
4	ICAM	ICAm	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
5	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
6	I	I	PRON	PRP	Case=Nom|Number=Sing|Person=1|PronType=Prs	_	_	_	_
7	promoter	promoter	VERB	VB	VerbForm=Inf	_	_	_	_
8	by	by	ADP	IN	_	_	_	_	_
9	TaxI	taxi	PROPN	NNP	Number=Sing	_	_	_	_
10	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
11	further	further	ADV	RB	_	_	_	_	_
12	shown	show	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
13	by	by	ADP	IN	_	_	_	_	_
14	co-transfection	co-transfection	NOUN	NN	Number=Sing	_	_	_	_
15	of	of	ADP	IN	_	_	_	_	_
16	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
17	CAT	cat	ADJ	JJ	Degree=Pos	_	_	_	_
18	reporter	reporter	NOUN	NN	Number=Sing	_	_	_	_
19	construct	construct	NOUN	NN	Number=Sing	_	_	_	_
20	with	with	ADP	IN	_	_	_	_	_
21	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
22	ICAM	ICAm	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
23	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
24	I	I	PRON	PRP	Case=Nom|Number=Sing|Person=1|PronType=Prs	_	_	_	_
25	promoter	promoter	VERB	VB	VerbForm=Inf	_	_	_	_
26	and	and	CCONJ	CC	_	_	_	_	_
27	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
28	plasmid	plasmid	NOUN	NN	Number=Sing	_	_	_	_
29	expressing	expresse	VERB	VBG	VerbForm=Ger	_	_	_	_
30	TaxI	taxi	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
31	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3512
# text = The mechanism of down-regulation of ICAM-I or LFA-I in 4 ATL cell lines was next examined.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	mechanism	mechanism	NOUN	NN	Number=Sing	_	_	_	_
3	of	of	ADP	IN	_	_	_	_	_
4	down	down	ADV	RB	_	_	_	_	SpaceAfter=No
5	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
6	regulation	regulation	NOUN	NN	Number=Sing	_	_	_	_
7	of	of	ADP	IN	_	_	_	_	_
8	ICAM	ICAm	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
9	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
10	I	I	PRON	PRP	Case=Nom|Number=Sing|Person=1|PronType=Prs	_	_	_	_
11	or	or	CCONJ	CC	_	_	_	_	_
12	LFA	LFA	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
13	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
14	I	I	PRON	PRP	Case=Nom|Number=Sing|Person=1|PronType=Prs	_	_	_	_
15	in	in	ADP	IN	_	_	_	_	_
16	4	4	NUM	CD	NumType=Card	_	_	_	_
17	ATL	Atl	ADJ	JJ	Degree=Pos	_	_	_	_
18	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
19	lines	line	NOUN	NNS	Number=Plur	_	_	_	_
20	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
21	next	next	ADV	RB	_	_	_	_	_
22	examined	examin	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	SpaceAfter=No
23	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3513
# text = ICAM-I mRNA was quite low in MT-I, but no genomic changes were found.
1	ICAM	ICAm	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
2	-	-	PUNCT	:	_	_	_	_	SpaceAfter=No
3	I	I	PRON	PRP	Case=Nom|Number=Sing|Person=1|PronType=Prs	_	_	_	_
4	mRNA	mRNA	PROPN	NNP	Number=Sing	_	_	_	_
5	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
6	quite	quite	ADV	RB	_	_	_	_	_
7	low	low	ADJ	JJ	Degree=Pos	_	_	_	_
8	in	in	ADP	IN	_	_	_	_	_
9	MT	Mt	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
10	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
11	I	I	PRON	PRP	Case=Nom|Number=Sing|Person=1|PronType=Prs	_	_	_	SpaceAfter=No
12	,	,	PUNCT	,	_	_	_	_	_
13	but	but	CCONJ	CC	_	_	_	_	_
14	no	no	DET	DT	_	_	_	_	_
15	genomic	genomic	ADJ	JJ	Degree=Pos	_	_	_	_
16	changes	change	NOUN	NNS	Number=Plur	_	_	_	_
17	were	be	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
18	found	find	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	SpaceAfter=No
19	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3514
# text = The CAT reporter with the ICAM-I promoter was inactive in MT-I.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	CAT	cat	ADJ	JJ	Degree=Pos	_	_	_	_
3	reporter	reporter	NOUN	NN	Number=Sing	_	_	_	_
4	with	with	ADP	IN	_	_	_	_	_
5	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
6	ICAM	ICAm	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
7	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
8	I	I	PRON	PRP	Case=Nom|Number=Sing|Person=1|PronType=Prs	_	_	_	_
9	promoter	promoter	NOUN	NN	Number=Sing	_	_	_	_
10	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
11	inactive	inactive	ADJ	JJ	Degree=Pos	_	_	_	_
12	in	in	ADP	IN	_	_	_	_	_
13	MT	mt	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
14	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
15	I	I	PRON	PRP	Case=Nom|Number=Sing|Person=1|PronType=Prs	_	_	_	SpaceAfter=No
16	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3515
# text = Finally, combined treatment of MT-I with 5-azacytidine and IFN-gamma induced re-expression of ICAM-I.
1	Finally	finally	ADV	RB	_	_	_	_	SpaceAfter=No
2	,	,	PUNCT	,	_	_	_	_	_
3	combined	combine	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
4	treatment	treatment	NOUN	NN	Number=Sing	_	_	_	_
5	of	of	ADP	IN	_	_	_	_	_
6	MT	mt	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
7	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
8	I	I	PRON	PRP	Case=Nom|Number=Sing|Person=1|PronType=Prs	_	_	_	_
9	with	with	ADP	IN	_	_	_	_	_
10	5	5	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
11	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
12	azacytidine	azacytidine	NOUN	NN	Number=Sing	_	_	_	_
13	and	and	CCONJ	CC	_	_	_	_	_
14	IFN	Ifn	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
15	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
16	gamma	gamma	NOUN	NN	Number=Sing	_	_	_	_
17	induced	induce	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
18	re-expression	re-expression	NOUN	NN	Number=Sing	_	_	_	_
19	of	of	ADP	IN	_	_	_	_	_
20	ICAM	ICAM	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
21	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
22	I	I	PRON	PRP	Case=Nom|Number=Sing|Person=1|PronType=Prs	_	_	_	SpaceAfter=No
23	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3516
# text = Collectively, (a) transcriptional factor(s) necessary for expression of ICAM-I gene may be repressed in MT-I through DNA methylation.
1	Collectively	collectively	ADV	RB	_	_	_	_	SpaceAfter=No
2	,	,	PUNCT	,	_	_	_	_	_
3	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
4	a	a	X	LS	_	_	_	_	SpaceAfter=No
5	)	)	PUNCT	-RRB-	_	_	_	_	_
6	transcriptional	transcriptional	ADJ	JJ	Degree=Pos	_	_	_	_
7	factor	factor	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
8	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
9	s	s	X	AFX	_	_	_	_	SpaceAfter=No
10	)	)	PUNCT	-RRB-	_	_	_	_	_
11	necessary	necessary	ADJ	JJ	Degree=Pos	_	_	_	_
12	for	for	ADP	IN	_	_	_	_	_
13	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
14	of	of	ADP	IN	_	_	_	_	_
15	ICAM	ICAM	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
16	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
17	I	I	PRON	PRP	Case=Nom|Number=Sing|Person=1|PronType=Prs	_	_	_	_
18	gene	gene	PRON	NN	Number=Sing	_	_	_	_
19	may	may	AUX	MD	VerbForm=Fin	_	_	_	_
20	be	be	AUX	VB	VerbForm=Inf	_	_	_	_
21	repressed	repress	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
22	in	in	ADP	IN	_	_	_	_	_
23	MT	mt	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
24	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
25	I	I	PRON	PRP	Case=Nom|Number=Sing|Person=1|PronType=Prs	_	_	_	_
26	through	through	ADP	IN	_	_	_	_	_
27	DNA	dna	NOUN	NN	Number=Sing	_	_	_	_
28	methylation	methylation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
29	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3517
# text = Three other ATL cell lines (TL-OmI, H582, HuT102) were found to have little mRNA for the LFA-I beta chain (CD18).
1	Three	Three	NUM	CD	NumType=Card	_	_	_	_
2	other	other	ADJ	JJ	Degree=Pos	_	_	_	_
3	ATL	Atl	ADJ	JJ	Degree=Pos	_	_	_	_
4	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
5	lines	line	NOUN	NNS	Number=Plur	_	_	_	_
6	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
7	TL	TL	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
8	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
9	OmI	OmI	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
10	,	,	PUNCT	,	_	_	_	_	_
11	H582	H582	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
12	,	,	PUNCT	,	_	_	_	_	_
13	HuT102	HuT102	X	LS	_	_	_	_	SpaceAfter=No
14	)	)	PUNCT	-RRB-	_	_	_	_	_
15	were	be	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
16	found	find	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
17	to	to	PART	TO	_	_	_	_	_
18	have	have	VERB	VB	VerbForm=Inf	_	_	_	_
19	little	little	ADJ	JJ	Degree=Pos	_	_	_	_
20	mRNA	mRNa	NOUN	NN	Number=Sing	_	_	_	_
21	for	for	ADP	IN	_	_	_	_	_
22	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
23	LFA	LFa	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
24	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
25	I	I	PRON	PRP	Case=Nom|Number=Sing|Person=1|PronType=Prs	_	_	_	_
26	beta	beof	ADP	IN	Abbr=Yes	_	_	_	_
27	chain	chain	NOUN	NN	Number=Sing	_	_	_	_
28	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
29	CD	cd	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
30	18	18	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
31	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
32	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3518
# text = H582 and HuT102 were also negative for the LFA-I alpha chain (CDIIa) mRNA.
1	H582	H582	NOUN	NN	Number=Sing	_	_	_	_
2	and	and	CCONJ	CC	_	_	_	_	_
3	HuT102	HuT102	NOUN	NN	Number=Sing	_	_	_	_
4	were	be	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
5	also	also	ADV	RB	_	_	_	_	_
6	negative	negative	ADJ	JJ	Degree=Pos	_	_	_	_
7	for	for	ADP	IN	_	_	_	_	_
8	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
9	LFA	LFa	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
10	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
11	I	I	PRON	PRP	Case=Nom|Number=Sing|Person=1|PronType=Prs	_	_	_	_
12	alpha	alpha	X	FW	Foreign=Yes	_	_	_	_
13	chain	chain	NOUN	NN	Number=Sing	_	_	_	_
14	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
15	CDIIa	CDIIa	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
16	)	)	PUNCT	-RRB-	_	_	_	_	_
17	mRNA	mRNa	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
18	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3519
# text = No genomic changes were found, and a CAT reporter gene with the CD18 promoter was inactive in the 3 of them, again suggesting lack of (a) transcriptional factor(s) necessary for CD18 expression.
1	No	no	DET	DT	_	_	_	_	_
2	genomic	genomic	ADJ	JJ	Degree=Pos	_	_	_	_
3	changes	change	NOUN	NNS	Number=Plur	_	_	_	_
4	were	be	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
5	found	find	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	SpaceAfter=No
6	,	,	PUNCT	,	_	_	_	_	_
7	and	and	CCONJ	CC	_	_	_	_	_
8	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
9	CAT	cat	ADJ	JJ	Degree=Pos	_	_	_	_
10	reporter	reporter	NOUN	NN	Number=Sing	_	_	_	_
11	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
12	with	with	ADP	IN	_	_	_	_	_
13	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
14	CD	cd	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
15	18	18	NUM	CD	NumType=Card	_	_	_	_
16	promoter	promoter	NOUN	NN	Number=Sing	_	_	_	_
17	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
18	inactive	inactive	ADJ	JJ	Degree=Pos	_	_	_	_
19	in	in	ADP	IN	_	_	_	_	_
20	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
21	3	3	NUM	CD	NumType=Card	_	_	_	_
22	of	of	ADP	IN	_	_	_	_	_
23	them	they	PRON	PRP	Case=Acc|Number=Plur|Person=3|PronType=Prs	_	_	_	SpaceAfter=No
24	,	,	PUNCT	,	_	_	_	_	_
25	again	again	ADV	RB	_	_	_	_	_
26	suggesting	suggest	VERB	VBG	VerbForm=Ger	_	_	_	_
27	lack	lack	NOUN	NN	Number=Sing	_	_	_	_
28	of	of	ADP	IN	_	_	_	_	_
29	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
30	a	a	X	LS	_	_	_	_	SpaceAfter=No
31	)	)	PUNCT	-RRB-	_	_	_	_	_
32	transcriptional	transcriptional	ADJ	JJ	Degree=Pos	_	_	_	_
33	factor	factor	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
34	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
35	s	s	X	AFX	_	_	_	_	SpaceAfter=No
36	)	)	PUNCT	-RRB-	_	_	_	_	_
37	necessary	necessary	ADJ	JJ	Degree=Pos	_	_	_	_
38	for	for	ADP	IN	_	_	_	_	_
39	CD	cd	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
40	18	18	NUM	CD	NumType=Card	_	_	_	_
41	expression	expression	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
42	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 3520
# text = Document 003003484 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	003003484	003003484	NUM	CD	NumType=Card	_	_	_	_
3	ends.	ends.	NOUN	NN	Number=Sing	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 3521
# text = SOCS-3 is tyrosine phosphorylated in response to interleukin-2 and suppresses STAT5 phosphorylation and lymphocyte proliferation.
1	SOCS	sOCs	ADV	RB	_	_	_	_	SpaceAfter=No
2	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
3	3	3	NUM	CD	NumType=Card	_	_	_	_
4	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
5	tyrosine	tyrosine	PRON	PRP	_	_	_	_	_
6	phosphorylated	phosphorylate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
7	in	in	ADP	IN	_	_	_	_	_
8	response	response	NOUN	NN	Number=Sing	_	_	_	_
9	to	to	PART	TO	_	_	_	_	_
10	interleukin	interleukin	VERB	VB	VerbForm=Inf	_	_	_	SpaceAfter=No
11	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
12	2	2	NUM	CD	NumType=Card	_	_	_	_
13	and	and	CCONJ	CC	_	_	_	_	_
14	suppresses	suppress	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
15	STAT5	STAT5	NUM	CD	NumType=Card	_	_	_	_
16	phosphorylation	phosphorylation	NOUN	NN	Number=Sing	_	_	_	_
17	and	and	CCONJ	CC	_	_	_	_	_
18	lymphocyte	lymphocyte	NOUN	NN	Number=Sing	_	_	_	_
19	proliferation	proliferation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
20	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 3522
# text = Members of the recently discovered SOCS/CIS/SSI family have been proposed as regulators of cytokine signaling, and while targets and mechanisms have been suggested for some family members, the precise role of these proteins remains to be defined.
1	Members	member	NOUN	NNS	Number=Plur	_	_	_	_
2	of	of	ADP	IN	_	_	_	_	_
3	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
4	recently	recently	ADV	RB	_	_	_	_	_
5	discovered	discovered	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
6	SOCS/CIS	sOCS/CIs	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
7	/	/	PUNCT	,	_	_	_	_	SpaceAfter=No
8	SSI	Ssi	PROPN	NNP	Number=Sing	_	_	_	_
9	family	family	NOUN	NN	Number=Sing	_	_	_	_
10	have	have	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
11	been	be	AUX	VBN	Tense=Past|VerbForm=Part	_	_	_	_
12	proposed	propose	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
13	as	as	ADP	IN	_	_	_	_	_
14	regulators	regulator	NOUN	NNS	Number=Plur	_	_	_	_
15	of	of	ADP	IN	_	_	_	_	_
16	cytokine	cytokine	NOUN	NN	Number=Sing	_	_	_	_
17	signaling	signaling	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
18	,	,	PUNCT	,	_	_	_	_	_
19	and	and	CCONJ	CC	_	_	_	_	_
20	while	while	SCONJ	IN	_	_	_	_	_
21	targets	target	NOUN	NNS	Number=Plur	_	_	_	_
22	and	and	CCONJ	CC	_	_	_	_	_
23	mechanisms	mechanism	NOUN	NNS	Number=Plur	_	_	_	_
24	have	have	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
25	been	be	AUX	VBN	Tense=Past|VerbForm=Part	_	_	_	_
26	suggested	suggest	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
27	for	for	ADP	IN	_	_	_	_	_
28	some	some	DET	DT	_	_	_	_	_
29	family	family	NOUN	NN	Number=Sing	_	_	_	_
30	members	member	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
31	,	,	PUNCT	,	_	_	_	_	_
32	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
33	precise	precise	ADJ	JJ	Degree=Pos	_	_	_	_
34	role	role	NOUN	NN	Number=Sing	_	_	_	_
35	of	of	ADP	IN	_	_	_	_	_
36	these	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
37	proteins	protein	NOUN	NNS	Number=Plur	_	_	_	_
38	remains	remain	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
39	to	to	PART	TO	_	_	_	_	_
40	be	be	AUX	VB	VerbForm=Inf	_	_	_	_
41	defined	define	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	SpaceAfter=No
42	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3523
# text = To date no SOCS proteins have been specifically implicated in interleukin-2 (IL-2) signaling in T cells.
1	To	to	ADP	IN	_	_	_	_	_
2	date	date	NOUN	NN	Number=Sing	_	_	_	_
3	no	no	DET	DT	_	_	_	_	_
4	SOCS	sOCs	NOUN	NN	Number=Sing	_	_	_	_
5	proteins	protein	NOUN	NNS	Number=Plur	_	_	_	_
6	have	have	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
7	been	be	AUX	VBN	Tense=Past|VerbForm=Part	_	_	_	_
8	specifically	specifically	ADV	RB	_	_	_	_	_
9	implicated	implicate	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
10	in	in	ADP	IN	_	_	_	_	_
11	interleukin	interleukin	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
12	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
13	2	2	NUM	CD	NumType=Card	_	_	_	_
14	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
15	IL	Il	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
16	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
17	2	2	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
18	)	)	PUNCT	-RRB-	_	_	_	_	_
19	signaling	signaling	VERB	VBG	VerbForm=Ger	_	_	_	_
20	in	in	ADP	IN	_	_	_	_	_
21	T	t	PROPN	NNP	Number=Sing	_	_	_	_
22	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
23	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3524
# text = Here we report SOCS-3 expression in response to IL-2 in both T-cell lines and human peripheral blood lymphocytes.
1	Here	here	ADV	RB	PronType=Dem	_	_	_	_
2	we	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
3	report	report	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
4	SOCS	SOCS	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
5	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
6	3	3	NUM	CD	NumType=Card	_	_	_	_
7	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
8	in	in	ADP	IN	_	_	_	_	_
9	response	response	NOUN	NN	Number=Sing	_	_	_	_
10	to	to	ADP	IN	_	_	_	_	_
11	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
12	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
13	2	2	NUM	CD	NumType=Card	_	_	_	_
14	in	in	ADP	IN	_	_	_	_	_
15	both	both	DET	DT	_	_	_	_	_
16	T-	t-	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
17	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
18	lines	line	NOUN	NNS	Number=Plur	_	_	_	_
19	and	and	CCONJ	CC	_	_	_	_	_
20	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
21	peripheral	peripheral	ADJ	JJ	Degree=Pos	_	_	_	_
22	blood	blood	NOUN	NN	Number=Sing	_	_	_	_
23	lymphocytes	lymphocyte	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
24	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3525
# text = SOCS-3 protein was detectable as early as 30 min following IL-2 stimulation, while CIS was seen only at low levels after 2 h.
1	SOCS	sOCs	ADV	RB	_	_	_	_	SpaceAfter=No
2	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
3	3	3	NUM	CD	NumType=Card	_	_	_	_
4	protein	protein	NOUN	NN	Number=Sing	_	_	_	_
5	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
6	detectable	detectable	ADJ	JJ	Degree=Pos	_	_	_	_
7	as	as	ADV	RB	_	_	_	_	_
8	early	early	ADV	RB	Degree=Pos	_	_	_	_
9	as	as	ADP	IN	_	_	_	_	_
10	30	30	NUM	CD	NumType=Card	_	_	_	_
11	min	min	NOUN	NNS	Number=Plur	_	_	_	_
12	following	follow	VERB	VBG	VerbForm=Ger	_	_	_	_
13	IL	Il	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
14	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
15	2	2	NUM	CD	NumType=Card	_	_	_	_
16	stimulation	stimulation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
17	,	,	PUNCT	,	_	_	_	_	_
18	while	while	SCONJ	IN	_	_	_	_	_
19	CIS	CIS	PRON	DT	Number=Sing|PronType=Dem	_	_	_	_
20	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
21	seen	see	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
22	only	only	ADV	RB	_	_	_	_	_
23	at	at	ADP	IN	_	_	_	_	_
24	low	low	ADJ	JJ	Degree=Pos	_	_	_	_
25	levels	level	NOUN	NNS	Number=Plur	_	_	_	_
26	after	after	ADP	IN	_	_	_	_	_
27	2	2	NUM	CD	NumType=Card	_	_	_	_
28	h	h	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
29	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3526
# text = Unlike CIS, SOCS-3 was rapidly tyrosine phosphorylated in response to IL-2.
1	Unlike	unlike	ADP	IN	_	_	_	_	_
2	CIS	CIS	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
3	,	,	PUNCT	,	_	_	_	_	_
4	SOCS	SOCS	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
5	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
6	3	3	NUM	CD	NumType=Card	_	_	_	_
7	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
8	rapidly	rapidly	ADV	RB	_	_	_	_	_
9	tyrosine	tyrosine	NOUN	NN	Number=Sing	_	_	_	_
10	phosphorylated	phosphorylate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
11	in	in	ADP	IN	_	_	_	_	_
12	response	response	NOUN	NN	Number=Sing	_	_	_	_
13	to	to	ADP	IN	_	_	_	_	_
14	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
15	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
16	2	2	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
17	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3527
# text = Tyrosine phosphorylation of SOCS-3 was observed upon coexpression with Jak1 and Jak2 but only weakly with Jak3.
1	Tyrosine	Tyrosine	NOUN	NN	Number=Sing	_	_	_	_
2	phosphorylation	phosphorylation	NOUN	NN	Number=Sing	_	_	_	_
3	of	of	ADP	IN	_	_	_	_	_
4	SOCS	SOCS	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
5	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
6	3	3	NUM	CD	NumType=Card	_	_	_	_
7	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
8	observed	observe	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
9	upon	upon	ADP	IN	_	_	_	_	_
10	coexpression	coexpression	NOUN	NN	Number=Sing	_	_	_	_
11	with	with	ADP	IN	_	_	_	_	_
12	Jak1	Jak1	NUM	CD	NumType=Card	_	_	_	_
13	and	and	CCONJ	CC	_	_	_	_	_
14	Jak2	Jak2	NUM	CD	NumType=Card	_	_	_	_
15	but	but	CCONJ	CC	_	_	_	_	_
16	only	only	ADV	RB	_	_	_	_	_
17	weakly	weakly	ADV	RB	_	_	_	_	_
18	with	with	ADP	IN	_	_	_	_	_
19	Jak3	Jak3	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
20	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3528
# text = In these experiments, SOCS-3 associated with Jak1 and inhibited Jak1 phosphorylation, and this inhibition was markedly enhanced by the presence of IL-2 receptor beta chain (IL-2Rbeta).
1	In	in	ADP	IN	_	_	_	_	_
2	these	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
3	experiments	experiment	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	,	,	PUNCT	,	_	_	_	_	_
5	SOCS	SOCS	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
6	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
7	3	3	NUM	CD	NumType=Card	_	_	_	_
8	associated	associate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
9	with	with	ADP	IN	_	_	_	_	_
10	Jak1	Jak1	PROPN	NNP	Number=Sing	_	_	_	_
11	and	and	CCONJ	CC	_	_	_	_	_
12	inhibited	inhibit	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
13	Jak1	Jak1	PROPN	NNP	Number=Sing	_	_	_	_
14	phosphorylation	phosphorylation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
15	,	,	PUNCT	,	_	_	_	_	_
16	and	and	CCONJ	CC	_	_	_	_	_
17	this	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
18	inhibition	inhibition	NOUN	NN	Number=Sing	_	_	_	_
19	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
20	markedly	markedly	ADV	RB	_	_	_	_	_
21	enhanced	enhance	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
22	by	by	ADP	IN	_	_	_	_	_
23	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
24	presence	presence	NOUN	NN	Number=Sing	_	_	_	_
25	of	of	ADP	IN	_	_	_	_	_
26	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
27	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
28	2	2	NUM	CD	NumType=Card	_	_	_	_
29	receptor	receptor	NOUN	NN	Number=Sing	_	_	_	_
30	beta	beta	NOUN	NN	Number=Sing	_	_	_	_
31	chain	chain	NOUN	NN	Number=Sing	_	_	_	_
32	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
33	IL	il	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
34	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
35	2	2	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
36	Rbeta	Rbeta	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
37	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
38	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3529
# text = Moreover, following IL-2 stimulation of T cells, SOCS-3 was able to interact with the IL-2 receptor complex, and in particular tyrosine phosphorylated Jak1 and IL-2Rbeta.
1	Moreover	moreover	ADV	RB	_	_	_	_	SpaceAfter=No
2	,	,	PUNCT	,	_	_	_	_	_
3	following	follow	VERB	VBG	VerbForm=Ger	_	_	_	_
4	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
5	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
6	2	2	NUM	CD	NumType=Card	_	_	_	_
7	stimulation	stimulation	NOUN	NN	Number=Sing	_	_	_	_
8	of	of	ADP	IN	_	_	_	_	_
9	T	t	PROPN	NNP	Number=Sing	_	_	_	_
10	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
11	,	,	PUNCT	,	_	_	_	_	_
12	SOCS	SOCS	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
13	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
14	3	3	NUM	CD	NumType=Card	_	_	_	_
15	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
16	able	able	ADJ	JJ	Degree=Pos	_	_	_	_
17	to	to	PART	TO	_	_	_	_	_
18	interact	interact	VERB	VB	VerbForm=Inf	_	_	_	_
19	with	with	ADP	IN	_	_	_	_	_
20	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
21	IL	Il	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
22	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
23	2	2	NUM	CD	NumType=Card	_	_	_	_
24	receptor	receptor	NOUN	NN	Number=Sing	_	_	_	_
25	complex	complex	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
26	,	,	PUNCT	,	_	_	_	_	_
27	and	and	CCONJ	CC	_	_	_	_	_
28	in	in	ADP	IN	_	_	_	_	_
29	particular	particular	ADJ	JJ	Degree=Pos	_	_	_	_
30	tyrosine	tyrosine	NOUN	NN	Number=Sing	_	_	_	_
31	phosphorylated	phosphorylate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
32	Jak1	Jak1	PROPN	NNP	Number=Sing	_	_	_	_
33	and	and	CCONJ	CC	_	_	_	_	_
34	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
35	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
36	2	2	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
37	Rbeta	Rbeta	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
38	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3530
# text = Additionally, in lymphocytes expressing SOCS-3 but not CIS, IL-2-induced tyrosine phosphorylation of STAT5b was markedly reduced, while there was only a weak effect on IL-3-mediated STAT5b tyrosine phosphorylation.
1	Additionally	additionally	ADV	RB	_	_	_	_	SpaceAfter=No
2	,	,	PUNCT	,	_	_	_	_	_
3	in	in	ADP	IN	_	_	_	_	_
4	lymphocytes	lymphocyte	NOUN	NNS	Number=Plur	_	_	_	_
5	expressing	express	VERB	VBG	VerbForm=Ger	_	_	_	_
6	SOCS	SOCS	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
7	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
8	3	3	NUM	CD	NumType=Card	_	_	_	_
9	but	but	CCONJ	CC	_	_	_	_	_
10	not	not	PART	RB	_	_	_	_	_
11	CIS	Cis	PROPN	NNPS	Number=Plur	_	_	_	SpaceAfter=No
12	,	,	PUNCT	,	_	_	_	_	_
13	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
14	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
15	2	2	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
16	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
17	induced	induce	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
18	tyrosine	tyrosine	NOUN	NN	Number=Sing	_	_	_	_
19	phosphorylation	phosphorylation	NOUN	NN	Number=Sing	_	_	_	_
20	of	of	ADP	IN	_	_	_	_	_
21	STAT5	stat5	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
22	b	b	NOUN	NN	Number=Sing	_	_	_	_
23	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
24	markedly	markedly	ADV	RB	_	_	_	_	_
25	reduced	reduce	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	SpaceAfter=No
26	,	,	PUNCT	,	_	_	_	_	_
27	while	while	SCONJ	IN	_	_	_	_	_
28	there	there	PRON	EX	_	_	_	_	_
29	was	be	VERB	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
30	only	only	ADV	RB	_	_	_	_	_
31	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
32	weak	weak	ADJ	JJ	Degree=Pos	_	_	_	_
33	effect	effect	NOUN	NN	Number=Sing	_	_	_	_
34	on	on	ADP	IN	_	_	_	_	_
35	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
36	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
37	3	3	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
38	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
39	mediated	mediate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
40	STAT5	stat5	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
41	b	b	NOUN	NN	Number=Sing	_	_	_	_
42	tyrosine	tyrosine	NOUN	NN	Number=Sing	_	_	_	_
43	phosphorylation	phosphorylation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
44	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3531
# text = Finally, proliferation induced by both IL-2- and IL-3 was significantly inhibited in the presence of SOCS-3.
1	Finally	finally	ADV	RB	_	_	_	_	SpaceAfter=No
2	,	,	PUNCT	,	_	_	_	_	_
3	proliferation	proliferation	NOUN	NN	Number=Sing	_	_	_	_
4	induced	induce	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
5	by	by	ADP	IN	_	_	_	_	_
6	both	both	DET	DT	_	_	_	_	_
7	IL	Il	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
8	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
9	2	2	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
10	-	-	PUNCT	HYPH	_	_	_	_	_
11	and	and	CCONJ	CC	_	_	_	_	_
12	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
13	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
14	3	3	NUM	CD	NumType=Card	_	_	_	_
15	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
16	significantly	significantly	ADV	RB	_	_	_	_	_
17	inhibited	inhibit	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
18	in	in	ADP	IN	_	_	_	_	_
19	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
20	presence	presence	NOUN	NN	Number=Sing	_	_	_	_
21	of	of	ADP	IN	_	_	_	_	_
22	SOCS	SOCS	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
23	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
24	3	3	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
25	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3532
# text = The findings suggest that when SOCS-3 is rapidly induced by IL-2 in T cells, it acts to inhibit IL-2 responses in a classical negative feedback loop.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	findings	finding	NOUN	NNS	Number=Plur	_	_	_	_
3	suggest	suggest	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
4	that	that	SCONJ	IN	_	_	_	_	_
5	when	when	ADV	WRB	PronType=Int	_	_	_	_
6	SOCS	SOCS	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
7	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
8	3	3	NUM	CD	NumType=Card	_	_	_	_
9	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
10	rapidly	rapidly	ADV	RB	_	_	_	_	_
11	induced	induce	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
12	by	by	ADP	IN	_	_	_	_	_
13	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
14	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
15	2	2	NUM	CD	NumType=Card	_	_	_	_
16	in	in	ADP	IN	_	_	_	_	_
17	T	t	PROPN	NNP	Number=Sing	_	_	_	_
18	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
19	,	,	PUNCT	,	_	_	_	_	_
20	it	it	PRON	PRP	Case=Nom|Gender=Neut|Number=Sing|Person=3|PronType=Prs	_	_	_	_
21	acts	act	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
22	to	to	PART	TO	_	_	_	_	_
23	inhibit	inhibit	VERB	VB	VerbForm=Inf	_	_	_	_
24	IL	Il	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
25	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
26	2	2	NUM	CD	NumType=Card	_	_	_	_
27	responses	response	NOUN	NNS	Number=Plur	_	_	_	_
28	in	in	ADP	IN	_	_	_	_	_
29	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
30	classical	classical	ADJ	JJ	Degree=Pos	_	_	_	_
31	negative	negative	ADJ	JJ	Degree=Pos	_	_	_	_
32	feedback	feedback	NOUN	NN	Number=Sing	_	_	_	_
33	loop	loop	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
34	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 3533
# text = Document 003003490 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	003003490	003003490	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 3534
# text = HIV-1 LTR activity in human CD40-activated B lymphocytes is dependent on NF-kappaB.
1	HIV	Hiv	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
2	-	-	PUNCT	:	_	_	_	_	SpaceAfter=No
3	1	1	NUM	CD	NumType=Card	_	_	_	_
4	LTR	Ltr	NOUN	NN	Number=Sing	_	_	_	_
5	activity	activity	NOUN	NN	Number=Sing	_	_	_	_
6	in	in	ADP	IN	_	_	_	_	_
7	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
8	CD40	CD40	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
9	-activated	-activate	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
10	B	b	ADJ	JJ	Degree=Pos	_	_	_	_
11	lymphocytes	lymphocyte	NOUN	NNS	Number=Plur	_	_	_	_
12	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
13	dependent	dependent	ADJ	JJ	Degree=Pos	_	_	_	_
14	on	on	ADP	IN	_	_	_	_	_
15	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
16	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
17	kappaB.	kappaB.	PROPN	NNP	Number=Sing	_	_	_	SpacesAfter=\s\n

# sent_id = 3535
# text = CD40-stimulated human B lymphocytes are highly permissive to a productive infection by the human immunodeficiency virus type 1.
1	CD40	CD40	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
2	-stimulated	-stimulated	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
3	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
4	B	b	NOUN	NN	Number=Sing	_	_	_	_
5	lymphocytes	lymphocyte	NOUN	NNS	Number=Plur	_	_	_	_
6	are	be	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
7	highly	highly	ADV	RB	_	_	_	_	_
8	permissive	permissive	ADJ	JJ	Degree=Pos	_	_	_	_
9	to	to	ADP	IN	_	_	_	_	_
10	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
11	productive	productive	ADJ	JJ	Degree=Pos	_	_	_	_
12	infection	infection	NOUN	NN	Number=Sing	_	_	_	_
13	by	by	ADP	IN	_	_	_	_	_
14	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
15	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
16	immunodeficiency	immunodeficiency	NOUN	NN	Number=Sing	_	_	_	_
17	virus	virus	NOUN	NN	Number=Sing	_	_	_	_
18	type	type	NOUN	NN	Number=Sing	_	_	_	_
19	1	1	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
20	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3536
# text = In these cells, nuclear factors involved in activation of the HIV-1 LTR, which contains the transcriptional control elements of the virus, are unknown.
1	In	in	ADP	IN	_	_	_	_	_
2	these	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
3	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	,	,	PUNCT	,	_	_	_	_	_
5	nuclear	nuclear	ADJ	JJ	Degree=Pos	_	_	_	_
6	factors	factor	NOUN	NNS	Number=Plur	_	_	_	_
7	involved	involve	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
8	in	in	ADP	IN	_	_	_	_	_
9	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
10	of	of	ADP	IN	_	_	_	_	_
11	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
12	HIV	Hiv	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
13	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
14	1	1	NUM	CD	NumType=Card	_	_	_	_
15	LTR	Ltr	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
16	,	,	PUNCT	,	_	_	_	_	_
17	which	which	PRON	WDT	PronType=Rel	_	_	_	_
18	contains	contain	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
19	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
20	transcriptional	transcriptional	ADJ	JJ	Degree=Pos	_	_	_	_
21	control	control	NOUN	NN	Number=Sing	_	_	_	_
22	elements	element	NOUN	NNS	Number=Plur	_	_	_	_
23	of	of	ADP	IN	_	_	_	_	_
24	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
25	virus	virus	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
26	,	,	PUNCT	,	_	_	_	_	_
27	are	be	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
28	unknown	unknown	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
29	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3537
# text = Transient expression assays with plasmids containing deleted parts of the LTR region linked to a reporter gene showed that the NF-kappaB binding site was essential for HIV-1 LTR activity in CD40-stimulated B lymphocytes.
1	Transient	Transient	ADJ	JJ	Degree=Pos	_	_	_	_
2	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
3	assays	assay	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
4	with	with	ADP	IN	_	_	_	_	_
5	plasmids	plasmid	NOUN	NNS	Number=Plur	_	_	_	_
6	containing	contain	VERB	VBG	VerbForm=Ger	_	_	_	_
7	deleted	delet	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
8	parts	part	NOUN	NNS	Number=Plur	_	_	_	_
9	of	of	ADP	IN	_	_	_	_	_
10	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
11	LTR	LTR	PROPN	NNP	Number=Sing	_	_	_	_
12	region	region	NOUN	NN	Number=Sing	_	_	_	_
13	linked	link	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
14	to	to	ADP	IN	_	_	_	_	_
15	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
16	reporter	reporter	NOUN	NN	Number=Sing	_	_	_	_
17	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
18	showed	show	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
19	that	that	SCONJ	IN	_	_	_	_	_
20	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
21	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
22	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
23	kappaB	kappaB	PROPN	NNP	Number=Sing	_	_	_	_
24	binding	binding	VERB	VBG	VerbForm=Ger	_	_	_	_
25	site	site	NOUN	NN	Number=Sing	_	_	_	_
26	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
27	essential	essential	ADJ	JJ	Degree=Pos	_	_	_	_
28	for	for	ADP	IN	_	_	_	_	_
29	HIV	HIV	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
30	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
31	1	1	NUM	CD	NumType=Card	_	_	_	_
32	LTR	Ltr	NOUN	NN	Number=Sing	_	_	_	_
33	activity	activity	NOUN	NN	Number=Sing	_	_	_	_
34	in	in	ADP	IN	_	_	_	_	_
35	CD40	CD40	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
36	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
37	stimulated	stimulate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
38	B	b	NOUN	NN	Number=Sing	_	_	_	_
39	lymphocytes	lymphocyte	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
40	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3538
# text = In addition, electrophoretic mobility shift and supershift assays revealed that important NF-kappaB binding activity composed of at least p50, p65, and c-Rel NF-kappaB subunits was present in nuclei of CD40-stimulated B cells.
1	In	in	ADP	IN	_	_	_	_	_
2	addition	addition	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
3	,	,	PUNCT	,	_	_	_	_	_
4	electrophoretic	electrophoretic	ADJ	JJ	Degree=Pos	_	_	_	_
5	mobility	mobility	NOUN	NN	Number=Sing	_	_	_	_
6	shift	shift	NOUN	NN	Number=Sing	_	_	_	_
7	and	and	CCONJ	CC	_	_	_	_	_
8	supershift	supershift	ADJ	JJ	Degree=Pos	_	_	_	_
9	assays	assay	NOUN	NNS	Number=Plur	_	_	_	_
10	revealed	reveal	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
11	that	that	SCONJ	IN	_	_	_	_	_
12	important	important	ADJ	JJ	Degree=Pos	_	_	_	_
13	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
14	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
15	kappaB	kappaB	PROPN	NNP	Number=Sing	_	_	_	_
16	binding	bind	VERB	VBG	VerbForm=Ger	_	_	_	_
17	activity	activity	NOUN	NN	Number=Sing	_	_	_	_
18	composed	compose	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
19	of	of	ADP	IN	_	_	_	_	_
20	at	at	ADV	RB	_	_	_	_	_
21	least	least	ADV	RBS	Degree=Sup	_	_	_	_
22	p50	p50	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
23	,	,	PUNCT	,	_	_	_	_	_
24	p65	p65	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
25	,	,	PUNCT	,	_	_	_	_	_
26	and	and	CCONJ	CC	_	_	_	_	_
27	c	c	NOUN	NN	Abbr=Yes|Number=Sing	_	_	_	SpaceAfter=No
28	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
29	Rel	Rel	PROPN	NNP	Number=Sing	_	_	_	_
30	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
31	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
32	kappaB	kappaB	PROPN	NNP	Number=Sing	_	_	_	_
33	subunits	subunit	NOUN	NNS	Number=Plur	_	_	_	_
34	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
35	present	present	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
36	in	in	ADP	IN	_	_	_	_	_
37	nuclei	nuclei	NOUN	NN	Number=Sing	_	_	_	_
38	of	of	ADP	IN	_	_	_	_	_
39	CD40	CD40	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
40	-	-	PUNCT	:	_	_	_	_	SpaceAfter=No
41	stimulated	stimulate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
42	B	b	ADJ	JJ	Degree=Pos	_	_	_	_
43	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
44	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3539
# text = These results confirm at a molecular level the ability of HIV-1 to replicate in B cells and that this activity is strongly associated with NF-kappaB.
1	These	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
2	results	result	NOUN	NNS	Number=Plur	_	_	_	_
3	confirm	confirm	VERB	VB	VerbForm=Inf	_	_	_	_
4	at	at	ADP	IN	_	_	_	_	_
5	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
6	molecular	molecular	ADJ	JJ	Degree=Pos	_	_	_	_
7	level	level	NOUN	NN	Number=Sing	_	_	_	_
8	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
9	ability	ability	NOUN	NN	Number=Sing	_	_	_	_
10	of	of	ADP	IN	_	_	_	_	_
11	HIV	HIV	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
12	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
13	1	1	NUM	CD	NumType=Card	_	_	_	_
14	to	to	PART	TO	_	_	_	_	_
15	replicate	replicate	VERB	VB	VerbForm=Inf	_	_	_	_
16	in	in	ADP	IN	_	_	_	_	_
17	B	b	ADJ	JJ	Degree=Pos	_	_	_	_
18	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
19	and	and	CCONJ	CC	_	_	_	_	_
20	that	that	SCONJ	IN	_	_	_	_	_
21	this	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
22	activity	activity	NOUN	NN	Number=Sing	_	_	_	_
23	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
24	strongly	strongly	ADV	RB	_	_	_	_	_
25	associated	associate	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
26	with	with	ADP	IN	_	_	_	_	_
27	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
28	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
29	kappaB.	kappaB.	PROPN	NNP	Number=Sing	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 3540
# text = Document 003003493 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	003003493	003003493	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 3541
# text = Oxidative stress triggers STAT3 tyrosine phosphorylation and nuclear translocation in human lymphocytes.
1	Oxidative	Oxidative	ADJ	JJ	Degree=Pos	_	_	_	_
2	stress	stress	NOUN	NN	Number=Sing	_	_	_	_
3	triggers	trigger	NOUN	NNS	Number=Plur	_	_	_	_
4	STAT3	STAT3	NUM	CD	NumType=Card	_	_	_	_
5	tyrosine	tyrosine	NOUN	NN	Number=Sing	_	_	_	_
6	phosphorylation	phosphorylation	NOUN	NN	Number=Sing	_	_	_	_
7	and	and	CCONJ	CC	_	_	_	_	_
8	nuclear	nuclear	ADJ	JJ	Degree=Pos	_	_	_	_
9	translocation	translocation	NOUN	NN	Number=Sing	_	_	_	_
10	in	in	ADP	IN	_	_	_	_	_
11	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
12	lymphocytes	lymphocyte	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
13	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 3542
# text = Oxidizing agents are powerful activators of factors responsible for the transcriptional activation of cytokine-encoding genes involved in tissue injury.
1	Oxidizing	Oxidizing	ADJ	JJ	Degree=Pos	_	_	_	_
2	agents	agent	NOUN	NNS	Number=Plur	_	_	_	_
3	are	be	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
4	powerful	powerful	ADJ	JJ	Degree=Pos	_	_	_	_
5	activators	activator	NOUN	NNS	Number=Plur	_	_	_	_
6	of	of	ADP	IN	_	_	_	_	_
7	factors	factor	NOUN	NNS	Number=Plur	_	_	_	_
8	responsible	responsible	ADJ	JJ	Degree=Pos	_	_	_	_
9	for	for	ADP	IN	_	_	_	_	_
10	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
11	transcriptional	transcriptional	ADJ	JJ	Degree=Pos	_	_	_	_
12	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
13	of	of	ADP	IN	_	_	_	_	_
14	cytokine	cytokine	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
15	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
16	encoding	encoding	VERB	VBG	VerbForm=Ger	_	_	_	_
17	genes	gene	NOUN	NNS	Number=Plur	_	_	_	_
18	involved	involved	ADJ	JJ	Degree=Pos	_	_	_	_
19	in	in	ADP	IN	_	_	_	_	_
20	tissue	tissue	ADJ	JJ	Degree=Pos	_	_	_	_
21	injury	injury	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
22	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3543
# text = In this study we show evidence that STAT3 is a transcription factor whose activity is modulated by H2O2 in human lymphocytes, in which endogenous catalase had previously been inhibited.
1	In	in	ADP	IN	_	_	_	_	_
2	this	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
3	study	study	NOUN	NN	Number=Sing	_	_	_	_
4	we	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
5	show	show	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
6	evidence	evidence	SCONJ	IN	_	_	_	_	_
7	that	that	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
8	STAT3	STAT3	NOUN	NN	Number=Sing	_	_	_	_
9	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
10	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
11	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
12	factor	factor	NOUN	NN	Number=Sing	_	_	_	_
13	whose	whose	PRON	WP$	Poss=Yes|PronType=Int	_	_	_	_
14	activity	activity	NOUN	NN	Number=Sing	_	_	_	_
15	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
16	modulated	modulate	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
17	by	by	ADP	IN	_	_	_	_	_
18	H2O2	H2O2	NUM	CD	NumType=Card	_	_	_	_
19	in	in	ADP	IN	_	_	_	_	_
20	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
21	lymphocytes	lymphocyte	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
22	,	,	PUNCT	,	_	_	_	_	_
23	in	in	ADP	IN	_	_	_	_	_
24	which	which	PRON	WDT	PronType=Rel	_	_	_	_
25	endogenous	endogenous	ADJ	JJ	Degree=Pos	_	_	_	_
26	catalase	catalase	NOUN	NN	Number=Sing	_	_	_	_
27	had	have	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
28	previously	previously	ADV	RB	_	_	_	_	_
29	been	be	AUX	VBN	Tense=Past|VerbForm=Part	_	_	_	_
30	inhibited	inhibit	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	SpaceAfter=No
31	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3544
# text = H2O2-induced nuclear translocation of STAT3 to form sequence-specific DNA-bound complexes was evidenced by immunoblotting of nuclear fractions and electrophoretic mobility shift assays, and vanadate was found to strongly synergize with H2O2.
1	H2O2	H2O2	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
2	-	-	PUNCT	:	_	_	_	_	SpaceAfter=No
3	induced	induce	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
4	nuclear	nuclear	ADJ	JJ	Degree=Pos	_	_	_	_
5	translocation	translocation	NOUN	NN	Number=Sing	_	_	_	_
6	of	of	ADP	IN	_	_	_	_	_
7	STAT3	STAT3	NOUN	NN	Number=Sing	_	_	_	_
8	to	to	PART	TO	_	_	_	_	_
9	form	form	VERB	VB	VerbForm=Inf	_	_	_	_
10	sequence	sequence	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
11	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
12	specific	specific	ADJ	JJ	Degree=Pos	_	_	_	_
13	DNA	dna	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
14	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
15	bound	bound	ADJ	JJ	Degree=Pos	_	_	_	_
16	complexes	complex	NOUN	NNS	Number=Plur	_	_	_	_
17	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
18	evidenced	evidence	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
19	by	by	SCONJ	IN	_	_	_	_	_
20	immunoblotting	immunoblott	VERB	VBG	VerbForm=Ger	_	_	_	_
21	of	of	ADP	IN	_	_	_	_	_
22	nuclear	nuclear	ADJ	JJ	Degree=Pos	_	_	_	_
23	fractions	fraction	NOUN	NNS	Number=Plur	_	_	_	_
24	and	and	CCONJ	CC	_	_	_	_	_
25	electrophoretic	electrophoretic	ADJ	JJ	Degree=Pos	_	_	_	_
26	mobility	mobility	NOUN	NN	Number=Sing	_	_	_	_
27	shift	shift	NOUN	NN	Number=Sing	_	_	_	_
28	assays	assay	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
29	,	,	PUNCT	,	_	_	_	_	_
30	and	and	CCONJ	CC	_	_	_	_	_
31	vanadate	vanadate	NOUN	NN	Number=Sing	_	_	_	_
32	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
33	found	find	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
34	to	to	PART	TO	_	_	_	_	_
35	strongly	strongly	ADV	RB	_	_	_	_	_
36	synergize	synergize	VERB	VB	VerbForm=Inf	_	_	_	_
37	with	with	ADP	IN	_	_	_	_	_
38	H2	H2	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
39	O2	O2	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
40	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3545
# text = Moreover, anti-STAT3 antibodies specifically precipitated a protein of 92 kDa that becomes phosphorylated on tyrosine upon lymphocyte treatment with H2O2.
1	Moreover	moreover	ADV	RB	_	_	_	_	SpaceAfter=No
2	,	,	PUNCT	,	_	_	_	_	_
3	anti-STAT3	anti-STAT3	NUM	CD	NumType=Card	_	_	_	_
4	antibodies	antibody	NOUN	NNS	Number=Plur	_	_	_	_
5	specifically	specifically	ADV	RB	_	_	_	_	_
6	precipitated	precipitate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
7	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
8	protein	protein	NOUN	NN	Number=Sing	_	_	_	_
9	of	of	ADP	IN	_	_	_	_	_
10	92	92	NUM	CD	NumType=Card	_	_	_	_
11	kDa	kDa	PROPN	NNP	Number=Sing	_	_	_	_
12	that	that	PRON	WDT	PronType=Rel	_	_	_	_
13	becomes	become	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
14	phosphorylated	phosphorylate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
15	on	on	ADP	IN	_	_	_	_	_
16	tyrosine	tyrosine	NOUN	NN	Number=Sing	_	_	_	_
17	upon	upon	ADP	IN	_	_	_	_	_
18	lymphocyte	lymphocyte	ADJ	JJ	Degree=Pos	_	_	_	_
19	treatment	treatment	NOUN	NN	Number=Sing	_	_	_	_
20	with	with	ADP	IN	_	_	_	_	_
21	H2	H2	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
22	O2	O2	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
23	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3546
# text = Phenylarsine oxide, a tyrosine phosphatase inhibitor, and genistein, a tyrosine kinase inhibitor, cooperated and cancelled, respectively, the H2O2-promoted STAT3 nuclear translocation.
1	Phenylarsine	Phenylarsine	VERB	VB	Mood=Imp|VerbForm=Fin	_	_	_	_
2	oxide	oxide	ADV	RB	_	_	_	_	SpaceAfter=No
3	,	,	PUNCT	,	_	_	_	_	_
4	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
5	tyrosine	tyrosine	NOUN	NN	Number=Sing	_	_	_	_
6	phosphatase	phosphatase	NOUN	NN	Number=Sing	_	_	_	_
7	inhibitor	inhibitor	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
8	,	,	PUNCT	,	_	_	_	_	_
9	and	and	CCONJ	CC	_	_	_	_	_
10	genistein	genistein	VERB	VB	Mood=Imp|VerbForm=Fin	_	_	_	SpaceAfter=No
11	,	,	PUNCT	,	_	_	_	_	_
12	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
13	tyrosine	tyrosine	NOUN	NN	Number=Sing	_	_	_	_
14	kinase	kinase	NOUN	NN	Number=Sing	_	_	_	_
15	inhibitor	inhibitor	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
16	,	,	PUNCT	,	_	_	_	_	_
17	cooperated	cooperate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
18	and	and	CCONJ	CC	_	_	_	_	_
19	cancelled	cancell	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	SpaceAfter=No
20	,	,	PUNCT	,	_	_	_	_	_
21	respectively	respectively	ADV	RB	_	_	_	_	SpaceAfter=No
22	,	,	PUNCT	,	_	_	_	_	_
23	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
24	H2O2	h2o2	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
25	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
26	promoted	promote	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
27	STAT3	STAT3	NUM	CD	NumType=Card	_	_	_	_
28	nuclear	nuclear	ADJ	JJ	Degree=Pos	_	_	_	_
29	translocation	translocation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
30	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3547
# text = Evidence is also presented, using Fe2+/Cu2+ ions, that.OH generated from H2O2 through Fenton reactions could be a candidate oxygen reactive species to directly activate STAT3.
1	Evidence	evidence	NOUN	NN	Number=Sing	_	_	_	_
2	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
3	also	also	ADV	RB	_	_	_	_	_
4	presented	present	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	SpaceAfter=No
5	,	,	PUNCT	,	_	_	_	_	_
6	using	use	VERB	VBG	VerbForm=Ger	_	_	_	_
7	Fe2+/Cu2	Fe2+/Cu2	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
8	+	+	SYM	SYM	_	_	_	_	_
9	ions	ion	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
10	,	,	PUNCT	,	_	_	_	_	_
11	that.OH	that.Oh	PROPN	NNP	Number=Sing	_	_	_	_
12	generated	generate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
13	from	from	ADP	IN	_	_	_	_	_
14	H2O2	H2O2	NOUN	NN	Number=Sing	_	_	_	_
15	through	through	ADP	IN	_	_	_	_	_
16	Fenton	Fenton	PROPN	NNP	Number=Sing	_	_	_	_
17	reactions	reaction	NOUN	NNS	Number=Plur	_	_	_	_
18	could	could	AUX	MD	VerbForm=Fin	_	_	_	_
19	be	be	AUX	VB	VerbForm=Inf	_	_	_	_
20	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
21	candidate	candidate	NOUN	NN	Number=Sing	_	_	_	_
22	oxygen	oxygen	ADJ	JJ	Degree=Pos	_	_	_	_
23	reactive	reactive	ADJ	JJ	Degree=Pos	_	_	_	_
24	species	species	NOUN	NNS	Number=Plur	_	_	_	_
25	to	to	PART	TO	_	_	_	_	_
26	directly	directly	ADV	RB	_	_	_	_	_
27	activate	activate	VERB	VB	VerbForm=Inf	_	_	_	_
28	STAT3	STAT3	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
29	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3548
# text = Present data suggest that H2O2 and vanadate are likely to inhibit the activity of intracellular tyrosine phosphatase(s), leading to enhanced STAT3 tyrosine phosphorylation and hence its translocation to the nucleus.
1	Present	present	ADJ	JJ	Degree=Pos	_	_	_	_
2	data	data	NOUN	NN	Number=Sing	_	_	_	_
3	suggest	suggest	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
4	that	that	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
5	H2O2	h2o2	NOUN	NN	Number=Sing	_	_	_	_
6	and	and	CCONJ	CC	_	_	_	_	_
7	vanadate	vanadate	NOUN	NN	Number=Sing	_	_	_	_
8	are	be	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
9	likely	likely	ADJ	JJ	Degree=Pos	_	_	_	_
10	to	to	PART	TO	_	_	_	_	_
11	inhibit	inhibit	VERB	VB	VerbForm=Inf	_	_	_	_
12	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
13	activity	activity	NOUN	NN	Number=Sing	_	_	_	_
14	of	of	ADP	IN	_	_	_	_	_
15	intracellular	intracellular	ADJ	JJ	Degree=Pos	_	_	_	_
16	tyrosine	tyrosine	NOUN	NN	Number=Sing	_	_	_	_
17	phosphatase	phosphatase	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
18	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
19	s	s	X	AFX	_	_	_	_	SpaceAfter=No
20	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
21	,	,	PUNCT	,	_	_	_	_	_
22	leading	lead	VERB	VBG	VerbForm=Ger	_	_	_	_
23	to	to	PART	TO	_	_	_	_	_
24	enhanced	enhance	VERB	VB	VerbForm=Inf	_	_	_	_
25	STAT3	STAT3	NUM	CD	NumType=Card	_	_	_	_
26	tyrosine	tyrosine	NOUN	NN	Number=Sing	_	_	_	_
27	phosphorylation	phosphorylation	NOUN	NN	Number=Sing	_	_	_	_
28	and	and	CCONJ	CC	_	_	_	_	_
29	hence	hence	ADV	RB	_	_	_	_	_
30	its	its	PRON	PRP$	Gender=Neut|Number=Sing|Person=3|Poss=Yes|PronType=Prs	_	_	_	_
31	translocation	translocation	NOUN	NN	Number=Sing	_	_	_	_
32	to	to	ADP	IN	_	_	_	_	_
33	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
34	nucleus	nucleus	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
35	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3549
# text = These results demonstrate that the DNA binding activity of STAT3 can be modulated by oxidizing agents and provide a framework to understand the effects of oxidative stress on the JAK-STAT signaling pathway.
1	These	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
2	results	result	NOUN	NNS	Number=Plur	_	_	_	_
3	demonstrate	demonstrate	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
4	that	that	SCONJ	IN	_	_	_	_	_
5	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
6	DNA	dna	NOUN	NN	Number=Sing	_	_	_	_
7	binding	binding	VERB	VBG	VerbForm=Ger	_	_	_	_
8	activity	activity	NOUN	NN	Number=Sing	_	_	_	_
9	of	of	ADP	IN	_	_	_	_	_
10	STAT3	STAT3	NOUN	NN	Number=Sing	_	_	_	_
11	can	can	AUX	MD	VerbForm=Fin	_	_	_	_
12	be	be	AUX	VB	VerbForm=Inf	_	_	_	_
13	modulated	modulate	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
14	by	by	SCONJ	IN	_	_	_	_	_
15	oxidizing	oxidize	VERB	VBG	VerbForm=Ger	_	_	_	_
16	agents	agent	NOUN	NNS	Number=Plur	_	_	_	_
17	and	and	CCONJ	CC	_	_	_	_	_
18	provide	provide	VERB	VB	VerbForm=Inf	_	_	_	_
19	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
20	framework	framework	NOUN	NN	Number=Sing	_	_	_	_
21	to	to	PART	TO	_	_	_	_	_
22	understand	understand	VERB	VB	VerbForm=Inf	_	_	_	_
23	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
24	effects	effect	NOUN	NNS	Number=Plur	_	_	_	_
25	of	of	ADP	IN	_	_	_	_	_
26	oxidative	oxidative	ADJ	JJ	Degree=Pos	_	_	_	_
27	stress	stress	NOUN	NN	Number=Sing	_	_	_	_
28	on	on	ADP	IN	_	_	_	_	_
29	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
30	JAK	JAK	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
31	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
32	STAT	STAT	NOUN	NN	Number=Sing	_	_	_	_
33	signaling	signaling	NOUN	NN	Number=Sing	_	_	_	_
34	pathway	pathway	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
35	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 3550
# text = Document 003003494 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	003003494	003003494	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 3551
# text = 20-Epi analogues of 1,25-dihydroxyvitamin D3 are highly potent inducers of DRIP coactivator complex binding to the vitamin D3 receptor.
1	20	20	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
2	-	-	PUNCT	:	_	_	_	_	SpaceAfter=No
3	Epi	Epi	NOUN	NN	Number=Sing	_	_	_	_
4	analogues	analogue	NOUN	NNS	Number=Plur	_	_	_	_
5	of	of	ADP	IN	_	_	_	_	_
6	1,25	1,25	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
7	-	-	PUNCT	:	_	_	_	_	SpaceAfter=No
8	dihydroxyvitamin	dihydroxyvitamin	NOUN	NN	Number=Sing	_	_	_	_
9	D3	D3	NOUN	NN	Number=Sing	_	_	_	_
10	are	be	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
11	highly	highly	ADV	RB	_	_	_	_	_
12	potent	potent	ADJ	JJ	Degree=Pos	_	_	_	_
13	inducers	inducer	NOUN	NNS	Number=Plur	_	_	_	_
14	of	of	ADP	IN	_	_	_	_	_
15	DRIP	drip	NOUN	NN	Number=Sing	_	_	_	_
16	coactivator	coactivator	NOUN	NN	Number=Sing	_	_	_	_
17	complex	complex	NOUN	NN	Number=Sing	_	_	_	_
18	binding	bind	VERB	VBG	VerbForm=Ger	_	_	_	_
19	to	to	ADP	IN	_	_	_	_	_
20	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
21	vitamin	vitamin	NOUN	NN	Number=Sing	_	_	_	_
22	D3	D3	NOUN	NN	Number=Sing	_	_	_	_
23	receptor	receptor	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
24	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 3552
# text = 1,25-Dihydroxyvitamin D3 (1,25(OH)2D3) plays a major role in the stimulation of bone growth, mineralization, and intestinal calcium and phosphate absorption; it also acts as a general inhibitor of cellular proliferation.
1	1,25	1,25	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
2	-	-	PUNCT	:	_	_	_	_	SpaceAfter=No
3	Dihydroxyvitamin	Dihydroxyvitamin	NOUN	NN	Number=Sing	_	_	_	_
4	D3	D3	NOUN	NN	Number=Sing	_	_	_	_
5	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
6	1,25	1,25	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
7	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
8	OH	Oh	INTJ	UH	_	_	_	_	SpaceAfter=No
9	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
10	2D3	2D3	X	LS	_	_	_	_	SpaceAfter=No
11	)	)	PUNCT	-RRB-	_	_	_	_	_
12	plays	play	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
13	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
14	major	major	ADJ	JJ	Degree=Pos	_	_	_	_
15	role	role	NOUN	NN	Number=Sing	_	_	_	_
16	in	in	ADP	IN	_	_	_	_	_
17	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
18	stimulation	stimulation	NOUN	NN	Number=Sing	_	_	_	_
19	of	of	ADP	IN	_	_	_	_	_
20	bone	bone	NOUN	NN	Number=Sing	_	_	_	_
21	growth	growth	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
22	,	,	PUNCT	,	_	_	_	_	_
23	mineralization	mineralization	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
24	,	,	PUNCT	,	_	_	_	_	_
25	and	and	CCONJ	CC	_	_	_	_	_
26	intestinal	intestinal	ADJ	JJ	Degree=Pos	_	_	_	_
27	calcium	calcium	NOUN	NN	Number=Sing	_	_	_	_
28	and	and	CCONJ	CC	_	_	_	_	_
29	phosphate	phosphate	NOUN	NN	Number=Sing	_	_	_	_
30	absorption	absorption	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
31	;	;	PUNCT	,	_	_	_	_	_
32	it	it	PRON	PRP	Case=Nom|Gender=Neut|Number=Sing|Person=3|PronType=Prs	_	_	_	_
33	also	also	ADV	RB	_	_	_	_	_
34	acts	act	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
35	as	as	ADP	IN	_	_	_	_	_
36	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
37	general	general	ADJ	JJ	Degree=Pos	_	_	_	_
38	inhibitor	inhibitor	NOUN	NN	Number=Sing	_	_	_	_
39	of	of	ADP	IN	_	_	_	_	_
40	cellular	cellular	ADJ	JJ	Degree=Pos	_	_	_	_
41	proliferation	proliferation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
42	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3553
# text = Several new, clinically relevant compounds dissociate antiproliferative and calcemic activities of 1,25(OH)2D3, but the molecular basis for this has not been clearly elucidated.
1	Several	several	ADJ	JJ	Degree=Pos	_	_	_	_
2	new	new	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
3	,	,	PUNCT	,	_	_	_	_	_
4	clinically	clinically	ADV	RB	_	_	_	_	_
5	relevant	relevant	ADJ	JJ	Degree=Pos	_	_	_	_
6	compounds	compound	NOUN	NNS	Number=Plur	_	_	_	_
7	dissociate	dissociate	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
8	antiproliferative	antiproliferative	ADJ	JJ	Degree=Pos	_	_	_	_
9	and	and	CCONJ	CC	_	_	_	_	_
10	calcemic	calcemic	ADJ	JJ	Degree=Pos	_	_	_	_
11	activities	activity	NOUN	NNS	Number=Plur	_	_	_	_
12	of	of	ADP	IN	_	_	_	_	_
13	1,25	1,25	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
14	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
15	OH	oh	INTJ	UH	_	_	_	_	SpaceAfter=No
16	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
17	2D3	2D3	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
18	,	,	PUNCT	,	_	_	_	_	_
19	but	but	CCONJ	CC	_	_	_	_	_
20	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
21	molecular	molecular	ADJ	JJ	Degree=Pos	_	_	_	_
22	basis	basis	NOUN	NN	Number=Sing	_	_	_	_
23	for	for	ADP	IN	_	_	_	_	_
24	this	this	PRON	DT	Number=Sing|PronType=Dem	_	_	_	_
25	has	have	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
26	not	not	PART	RB	_	_	_	_	_
27	been	be	AUX	VBN	Tense=Past|VerbForm=Part	_	_	_	_
28	clearly	clearly	ADV	RB	_	_	_	_	_
29	elucidated	elucidate	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	SpaceAfter=No
30	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3554
# text = Here, we tested whether the potency of one class of compounds, 20-epi analogues, to induce myeloid cell differentiation, is because of direct molecular effects on vitamin D receptor (VDR).
1	Here	here	ADV	RB	PronType=Dem	_	_	_	SpaceAfter=No
2	,	,	PUNCT	,	_	_	_	_	_
3	we	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
4	tested	test	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
5	whether	whether	SCONJ	IN	_	_	_	_	_
6	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
7	potency	potency	NOUN	NN	Number=Sing	_	_	_	_
8	of	of	ADP	IN	_	_	_	_	_
9	one	one	NUM	CD	NumType=Card	_	_	_	_
10	class	class	NOUN	NN	Number=Sing	_	_	_	_
11	of	of	ADP	IN	_	_	_	_	_
12	compounds	compound	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
13	,	,	PUNCT	,	_	_	_	_	_
14	20	20	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
15	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
16	epi	epi	NOUN	NN	Number=Sing	_	_	_	_
17	analogues	analogue	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
18	,	,	PUNCT	,	_	_	_	_	_
19	to	to	PART	TO	_	_	_	_	_
20	induce	induce	VERB	VB	VerbForm=Inf	_	_	_	_
21	myeloid	myeloid	ADJ	JJ	Degree=Pos	_	_	_	_
22	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
23	differentiation	differentiation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
24	,	,	PUNCT	,	_	_	_	_	_
25	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
26	because	because	ADP	IN	_	_	_	_	_
27	of	of	ADP	IN	_	_	_	_	_
28	direct	direct	ADJ	JJ	Degree=Pos	_	_	_	_
29	molecular	molecular	ADJ	JJ	Degree=Pos	_	_	_	_
30	effects	effect	NOUN	NNS	Number=Plur	_	_	_	_
31	on	on	ADP	IN	_	_	_	_	_
32	vitamin	vitamin	NOUN	NN	Number=Sing	_	_	_	_
33	D	d	NOUN	NN	Number=Sing	_	_	_	_
34	receptor	receptor	NOUN	NN	Number=Sing	_	_	_	_
35	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
36	VDR	VDR	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
37	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
38	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3555
# text = We report that two 20-epi analogues, MC1627 and MC1288, induced differentiation and transcription of p21(Waf1,Cip1), a key VDR target gene involved in growth inhibition, at a concentration 100-fold lower than that of 1,25(OH)2D3.
1	We	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
2	report	report	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
3	that	that	SCONJ	IN	_	_	_	_	_
4	two	two	NUM	CD	NumType=Card	_	_	_	_
5	20	20	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
6	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
7	epi	epi	NOUN	NN	Number=Sing	_	_	_	_
8	analogues	analogue	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
9	,	,	PUNCT	,	_	_	_	_	_
10	MC	Mc	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
11	1627	1627	NUM	CD	NumType=Card	_	_	_	_
12	and	and	CCONJ	CC	_	_	_	_	_
13	MC1288	MC1288	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
14	,	,	PUNCT	,	_	_	_	_	_
15	induced	induce	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
16	differentiation	differentiation	NOUN	NN	Number=Sing	_	_	_	_
17	and	and	CCONJ	CC	_	_	_	_	_
18	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
19	of	of	ADP	IN	_	_	_	_	_
20	p21	p21	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
21	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
22	Waf1	Waf1	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
23	,	,	PUNCT	,	_	_	_	_	SpaceAfter=No
24	Cip1	Cip1	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
25	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
26	,	,	PUNCT	,	_	_	_	_	_
27	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
28	key	key	ADJ	JJ	Degree=Pos	_	_	_	_
29	VDR	VDR	PROPN	NNP	Number=Sing	_	_	_	_
30	target	target	NOUN	NN	Number=Sing	_	_	_	_
31	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
32	involved	involved	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
33	in	in	ADP	IN	_	_	_	_	_
34	growth	growth	NOUN	NN	Number=Sing	_	_	_	_
35	inhibition	inhibition	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
36	,	,	PUNCT	,	_	_	_	_	_
37	at	at	ADP	IN	_	_	_	_	_
38	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
39	concentration	concentration	NOUN	NN	Number=Sing	_	_	_	_
40	100	100	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
41	-	-	PUNCT	:	_	_	_	_	SpaceAfter=No
42	fold	fold	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
43	lower	lower	ADJ	JJR	Degree=Cmp	_	_	_	_
44	than	than	ADP	IN	_	_	_	_	_
45	that	that	PRON	DT	Number=Sing|PronType=Dem	_	_	_	_
46	of	of	ADP	IN	_	_	_	_	_
47	1,25	1,25	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
48	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
49	OH	oh	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
50	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
51	2D3	2D3	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
52	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3556
# text = We compared this sensitivity to analogue effects on VDR interacting proteins: RXR, GRIP-1, and DRIP205, a subunit of the DRIP coactivator complex.
1	We	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
2	compared	compare	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
3	this	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
4	sensitivity	sensitivity	NOUN	NN	Number=Sing	_	_	_	_
5	to	to	PART	TO	_	_	_	_	_
6	analogue	analogue	VERB	VB	VerbForm=Inf	_	_	_	_
7	effects	effect	NOUN	NNS	Number=Plur	_	_	_	_
8	on	on	ADP	IN	_	_	_	_	_
9	VDR	Vdr	NOUN	NN	Number=Sing	_	_	_	_
10	interacting	interacting	VERB	VBG	VerbForm=Ger	_	_	_	_
11	proteins	protein	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
12	:	:	PUNCT	:	_	_	_	_	_
13	RXR	Rxr	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
14	,	,	PUNCT	,	_	_	_	_	_
15	GRIP	grip	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
16	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
17	1	1	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
18	,	,	PUNCT	,	_	_	_	_	_
19	and	and	CCONJ	CC	_	_	_	_	_
20	DRIP205	DRIP205	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
21	,	,	PUNCT	,	_	_	_	_	_
22	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
23	subunit	subunit	NOUN	NN	Number=Sing	_	_	_	_
24	of	of	ADP	IN	_	_	_	_	_
25	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
26	DRIP	drip	PROPN	NNP	Number=Sing	_	_	_	_
27	coactivator	coactivator	NOUN	NN	Number=Sing	_	_	_	_
28	complex	complex	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
29	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3557
# text = Compared with the interaction of VDR with RXR or GRIP-1, the differentiation dose-response most closely correlated to the ligand-dependent recruitment of the DRIP coactivator complex to VDR and to the ability of the receptor to activate transcription in a cell-free system.
1	Compared	compare	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
2	with	with	ADP	IN	_	_	_	_	_
3	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
4	interaction	interaction	NOUN	NN	Number=Sing	_	_	_	_
5	of	of	ADP	IN	_	_	_	_	_
6	VDR	VDR	PROPN	NNP	Number=Sing	_	_	_	_
7	with	with	ADP	IN	_	_	_	_	_
8	RXR	RXR	PROPN	NNP	Number=Sing	_	_	_	_
9	or	or	CCONJ	CC	_	_	_	_	_
10	GRIP	grip	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
11	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
12	1	1	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
13	,	,	PUNCT	,	_	_	_	_	_
14	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
15	differentiation	differentiation	NOUN	NN	Number=Sing	_	_	_	_
16	dose	dose	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
17	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
18	response	response	NOUN	NN	Number=Sing	_	_	_	_
19	most	most	ADV	RBS	_	_	_	_	_
20	closely	closely	ADV	RB	_	_	_	_	_
21	correlated	correlate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
22	to	to	ADP	IN	_	_	_	_	_
23	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
24	ligand	ligand	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
25	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
26	dependent	dependent	ADJ	JJ	Degree=Pos	_	_	_	_
27	recruitment	recruitment	NOUN	NN	Number=Sing	_	_	_	_
28	of	of	ADP	IN	_	_	_	_	_
29	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
30	DRIP	drip	PROPN	NNP	Number=Sing	_	_	_	_
31	coactivator	coactivator	NOUN	NN	Number=Sing	_	_	_	_
32	complex	complex	NOUN	NN	Number=Sing	_	_	_	_
33	to	to	ADP	IN	_	_	_	_	_
34	VDR	VDR	PROPN	NNP	Number=Sing	_	_	_	_
35	and	and	CCONJ	CC	_	_	_	_	_
36	to	to	ADP	IN	_	_	_	_	_
37	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
38	ability	ability	NOUN	NN	Number=Sing	_	_	_	_
39	of	of	ADP	IN	_	_	_	_	_
40	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
41	receptor	receptor	NOUN	NN	Number=Sing	_	_	_	_
42	to	to	PART	TO	_	_	_	_	_
43	activate	activate	VERB	VB	VerbForm=Inf	_	_	_	_
44	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
45	in	in	ADP	IN	_	_	_	_	_
46	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
47	cell	cell	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
48	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
49	free	free	ADJ	JJ	Degree=Pos	_	_	_	_
50	system	system	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
51	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3558
# text = These results provide compelling links between the efficiency of the 20-epi analogue in inducing VDR/DRIP interactions, transactivation in vitro, and its enhanced ability to induce cellular differentiation.
1	These	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
2	results	result	NOUN	NNS	Number=Plur	_	_	_	_
3	provide	provide	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
4	compelling	compelling	ADJ	JJ	Degree=Pos	_	_	_	_
5	links	link	NOUN	NNS	Number=Plur	_	_	_	_
6	between	between	ADP	IN	_	_	_	_	_
7	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
8	efficiency	efficiency	NOUN	NN	Number=Sing	_	_	_	_
9	of	of	ADP	IN	_	_	_	_	_
10	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
11	20	20	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
12	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
13	epi	epi	NOUN	NN	Number=Sing	_	_	_	_
14	analogue	analogue	NOUN	NN	Number=Sing	_	_	_	_
15	in	in	SCONJ	IN	_	_	_	_	_
16	inducing	induce	VERB	VBG	VerbForm=Ger	_	_	_	_
17	VDR	VDR	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
18	/	/	PUNCT	,	_	_	_	_	SpaceAfter=No
19	DRIP	drip	NOUN	NN	Number=Sing	_	_	_	_
20	interactions	interaction	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
21	,	,	PUNCT	,	_	_	_	_	_
22	transactivation	transactivation	NOUN	NN	Number=Sing	_	_	_	_
23	in	in	ADP	IN	_	_	_	_	_
24	vitro	vitro	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
25	,	,	PUNCT	,	_	_	_	_	_
26	and	and	CCONJ	CC	_	_	_	_	_
27	it	it	PRON	PRP	Case=Nom|Gender=Neut|Number=Sing|Person=3|PronType=Prs	_	_	_	SpaceAfter=No
28	s	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
29	enhanced	enhance	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
30	ability	ability	NOUN	NN	Number=Sing	_	_	_	_
31	to	to	PART	TO	_	_	_	_	_
32	induce	induce	VERB	VB	VerbForm=Inf	_	_	_	_
33	cellular	cellular	ADJ	JJ	Degree=Pos	_	_	_	_
34	differentiation	differentiation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
35	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 3559
# text = Document 003003495 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	003003495	003003495	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 3560
# text = Expression of Th1 and Th2 type cytokines responding to HBsAg and HBxAg in chronic hepatitis B patients.
1	Expression	expression	NOUN	NN	Number=Sing	_	_	_	_
2	of	of	ADP	IN	_	_	_	_	_
3	Th1	Th1	NUM	CD	NumType=Card	_	_	_	_
4	and	and	CCONJ	CC	_	_	_	_	_
5	Th2	Th2	NUM	CD	NumType=Card	_	_	_	_
6	type	type	NOUN	NN	Number=Sing	_	_	_	_
7	cytokines	cytokine	NOUN	NNS	Number=Plur	_	_	_	_
8	responding	respond	VERB	VBG	VerbForm=Ger	_	_	_	_
9	to	to	ADP	IN	_	_	_	_	_
10	HBsAg	HBsAg	PROPN	NNP	Number=Sing	_	_	_	_
11	and	and	CCONJ	CC	_	_	_	_	_
12	HBxAg	HBxAg	PROPN	NNP	Number=Sing	_	_	_	_
13	in	in	ADP	IN	_	_	_	_	_
14	chronic	chronic	ADJ	JJ	Degree=Pos	_	_	_	_
15	hepatitis	hepatitis	NOUN	NN	Number=Sing	_	_	_	_
16	B	b	NOUN	NN	Number=Sing	_	_	_	_
17	patients	patient	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
18	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 3561
# text = The cytokine pattern on viral antigen recognition is believed to exert a profound influence on the resolution of viral infections and viral clearance.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	cytokine	cytokine	NOUN	NN	Number=Sing	_	_	_	_
3	pattern	pattern	NOUN	NN	Number=Sing	_	_	_	_
4	on	on	ADP	IN	_	_	_	_	_
5	viral	viral	ADJ	JJ	Degree=Pos	_	_	_	_
6	antigen	antigen	ADJ	JJ	Degree=Pos	_	_	_	_
7	recognition	recognition	NOUN	NN	Number=Sing	_	_	_	_
8	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
9	believed	believe	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
10	to	to	PART	TO	_	_	_	_	_
11	exert	exert	VERB	VB	VerbForm=Inf	_	_	_	_
12	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
13	profound	profound	ADJ	JJ	Degree=Pos	_	_	_	_
14	influence	influence	NOUN	NN	Number=Sing	_	_	_	_
15	on	on	ADP	IN	_	_	_	_	_
16	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
17	resolution	resolution	NOUN	NN	Number=Sing	_	_	_	_
18	of	of	ADP	IN	_	_	_	_	_
19	viral	viral	ADJ	JJ	Degree=Pos	_	_	_	_
20	infections	infection	NOUN	NNS	Number=Plur	_	_	_	_
21	and	and	CCONJ	CC	_	_	_	_	_
22	viral	viral	ADJ	JJ	Degree=Pos	_	_	_	_
23	clearance	clearance	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
24	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3562
# text = This study was initiated to investigate whether a cytokine imbalance oriented toward Th2 type response plays a role in chronic hepatitis B. Cytokine profiles of peripheral blood mononuclear cells associated with chronic hepatitis
1	This	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
2	study	study	NOUN	NN	Number=Sing	_	_	_	_
3	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
4	initiated	initiate	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
5	to	to	PART	TO	_	_	_	_	_
6	investigate	investigate	VERB	VB	VerbForm=Inf	_	_	_	_
7	whether	whether	SCONJ	IN	_	_	_	_	_
8	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
9	cytokine	cytokine	NOUN	NN	Number=Sing	_	_	_	_
10	imbalance	imbalance	NOUN	NN	Number=Sing	_	_	_	_
11	oriented	orient	ADJ	JJ	Degree=Pos	_	_	_	_
12	toward	toward	ADP	IN	_	_	_	_	_
13	Th2	Th2	NUM	CD	NumType=Card	_	_	_	_
14	type	type	NOUN	NN	Number=Sing	_	_	_	_
15	response	response	NOUN	NN	Number=Sing	_	_	_	_
16	plays	play	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
17	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
18	role	role	NOUN	NN	Number=Sing	_	_	_	_
19	in	in	ADP	IN	_	_	_	_	_
20	chronic	chronic	ADJ	JJ	Degree=Pos	_	_	_	_
21	hepatitis	hepatitis	NOUN	NN	Number=Sing	_	_	_	_
22	B.	B.	PROPN	NNP	Number=Sing	_	_	_	_
23	Cytokine	Cytokine	PROPN	NNP	Number=Sing	_	_	_	_
24	profiles	profile	NOUN	NNS	Number=Plur	_	_	_	_
25	of	of	ADP	IN	_	_	_	_	_
26	peripheral	peripheral	ADJ	JJ	Degree=Pos	_	_	_	_
27	blood	blood	NOUN	NN	Number=Sing	_	_	_	_
28	mononuclear	mononuclear	ADJ	JJ	Degree=Pos	_	_	_	_
29	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
30	associated	associate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
31	with	with	ADP	IN	_	_	_	_	_
32	chronic	chronic	NOUN	NN	Number=Sing	_	_	_	_
33	hepatitis	hepatitis	NOUN	NN	Number=Sing	_	_	_	_

# sent_id = 3563
# text = B were analysed by RT-PCR.
1	B	benefit	NOUN	NN	Number=Sing	_	_	_	_
2	were	be	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
3	analysed	analyse	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
4	by	by	ADP	IN	_	_	_	_	_
5	RT	Rt	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
6	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
7	PCR	PCR	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
8	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3564
# text = Upon HBsAg stimulation, expression of IFN-gamma, IL-2, IL-4, and IL-10 was detected in 41%, 8%, 41%, and 50% of the patients, respectively.
1	Upon	upon	ADP	IN	_	_	_	_	_
2	HBsAg	HBsAg	ADJ	JJ	Degree=Pos	_	_	_	_
3	stimulation	stimulation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
4	,	,	PUNCT	,	_	_	_	_	_
5	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
6	of	of	ADP	IN	_	_	_	_	_
7	IFN	IFN	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
8	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
9	gamma	gamma	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
10	,	,	PUNCT	,	_	_	_	_	_
11	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
12	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
13	2	2	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
14	,	,	PUNCT	,	_	_	_	_	_
15	IL	IL	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
16	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
17	4	4	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
18	,	,	PUNCT	,	_	_	_	_	_
19	and	and	CCONJ	CC	_	_	_	_	_
20	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
21	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
22	10	10	NUM	CD	NumType=Card	_	_	_	_
23	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
24	detected	detect	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
25	in	in	ADP	IN	_	_	_	_	_
26	41	41	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
27	%	%	SYM	NN	Number=Sing	_	_	_	SpaceAfter=No
28	,	,	PUNCT	,	_	_	_	_	_
29	8	8	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
30	%	%	SYM	NN	Number=Sing	_	_	_	SpaceAfter=No
31	,	,	PUNCT	,	_	_	_	_	_
32	41	41	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
33	%	%	SYM	NN	Number=Sing	_	_	_	SpaceAfter=No
34	,	,	PUNCT	,	_	_	_	_	_
35	and	and	CCONJ	CC	_	_	_	_	_
36	50	50	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
37	%	%	SYM	NN	Number=Sing	_	_	_	_
38	of	of	ADP	IN	_	_	_	_	_
39	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
40	patients	patient	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
41	,	,	PUNCT	,	_	_	_	_	_
42	respectively	respectively	ADV	RB	_	_	_	_	SpaceAfter=No
43	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3565
# text = Among these cytokines, the expression of IFN-gamma was associated with high levels of serum AST/ALT.
1	Among	among	ADP	IN	_	_	_	_	_
2	these	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
3	cytokines	cytokine	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	,	,	PUNCT	,	_	_	_	_	_
5	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
6	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
7	of	of	ADP	IN	_	_	_	_	_
8	IFN	IFN	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
9	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
10	gamma	gamma	NOUN	NN	Number=Sing	_	_	_	_
11	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
12	associated	associate	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
13	with	with	ADP	IN	_	_	_	_	_
14	high	high	ADJ	JJ	Degree=Pos	_	_	_	_
15	levels	level	NOUN	NNS	Number=Plur	_	_	_	_
16	of	of	ADP	IN	_	_	_	_	_
17	serum	serum	NOUN	NN	Number=Sing	_	_	_	_
18	AST	AST	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
19	/	/	PUNCT	,	_	_	_	_	SpaceAfter=No
20	ALT	ALT	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
21	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3566
# text = However, we could not prove that Th2 type cytokines had a protective effect on hepatocytes.
1	However	however	ADV	RB	_	_	_	_	SpaceAfter=No
2	,	,	PUNCT	,	_	_	_	_	_
3	we	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
4	could	could	AUX	MD	VerbForm=Fin	_	_	_	_
5	not	not	PART	RB	_	_	_	_	_
6	prove	prove	VERB	VB	VerbForm=Inf	_	_	_	_
7	that	that	SCONJ	IN	_	_	_	_	_
8	Th2	Th2	NUM	CD	NumType=Card	_	_	_	_
9	type	type	NOUN	NN	Number=Sing	_	_	_	_
10	cytokines	cytokine	NOUN	NNS	Number=Plur	_	_	_	_
11	had	have	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
12	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
13	protective	protective	ADJ	JJ	Degree=Pos	_	_	_	_
14	effect	effect	NOUN	NN	Number=Sing	_	_	_	_
15	on	on	ADP	IN	_	_	_	_	_
16	hepatocytes	hepatocyte	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
17	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3567
# text = Upon HBxAg stimulation, there was no recognizable association of cytokine patterns with AST/ALT levels.
1	Upon	upon	ADP	IN	_	_	_	_	_
2	HBxAg	HBxAg	ADJ	JJ	Degree=Pos	_	_	_	_
3	stimulation	stimulation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
4	,	,	PUNCT	,	_	_	_	_	_
5	there	there	PRON	EX	_	_	_	_	_
6	was	be	VERB	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
7	no	no	DET	DT	_	_	_	_	_
8	recognizable	recognizable	ADJ	JJ	Degree=Pos	_	_	_	_
9	association	association	NOUN	NN	Number=Sing	_	_	_	_
10	of	of	ADP	IN	_	_	_	_	_
11	cytokine	cytokine	NOUN	NN	Number=Sing	_	_	_	_
12	patterns	pattern	NOUN	NNS	Number=Plur	_	_	_	_
13	with	with	ADP	IN	_	_	_	_	_
14	AST	Ast	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
15	/	/	PUNCT	,	_	_	_	_	SpaceAfter=No
16	ALT	al	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
17	levels	level	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
18	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3568
# text = In conclusion, production of a Th1 cytokine, IFN-gamma, by HBsAg-reactive cells was associated with hepatocyte damage in chronic hepatitis B, while no counteracting effect of Th2 cytokines produced by those cells was observed.
1	In	in	ADP	IN	_	_	_	_	_
2	conclusion	conclusion	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
3	,	,	PUNCT	,	_	_	_	_	_
4	production	production	NOUN	NN	Number=Sing	_	_	_	_
5	of	of	ADP	IN	_	_	_	_	_
6	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
7	Th1	Th1	NUM	CD	NumType=Card	_	_	_	_
8	cytokine	cytokine	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
9	,	,	PUNCT	,	_	_	_	_	_
10	IFN	Ifn	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
11	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
12	gamma	gamma	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
13	,	,	PUNCT	,	_	_	_	_	_
14	by	by	ADP	IN	_	_	_	_	_
15	HBsAg	HBsAg	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
16	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
17	reactive	reactive	ADJ	JJ	Degree=Pos	_	_	_	_
18	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
19	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
20	associated	associate	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
21	with	with	ADP	IN	_	_	_	_	_
22	hepatocyte	hepatocyte	NOUN	NN	Number=Sing	_	_	_	_
23	damage	damage	NOUN	NN	Number=Sing	_	_	_	_
24	in	in	ADP	IN	_	_	_	_	_
25	chronic	chronic	ADJ	JJ	Degree=Pos	_	_	_	_
26	hepatitis	hepatitis	NOUN	NN	Number=Sing	_	_	_	_
27	B	b	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
28	,	,	PUNCT	,	_	_	_	_	_
29	while	while	SCONJ	IN	_	_	_	_	_
30	no	no	DET	DT	_	_	_	_	_
31	counteracting	counteract	NOUN	NN	Number=Sing	_	_	_	_
32	effect	effect	NOUN	NN	Number=Sing	_	_	_	_
33	of	of	ADP	IN	_	_	_	_	_
34	Th2	Th2	NUM	CD	NumType=Card	_	_	_	_
35	cytokines	cytokine	NOUN	NNS	Number=Plur	_	_	_	_
36	produced	produce	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
37	by	by	ADP	IN	_	_	_	_	_
38	those	those	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
39	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
40	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
41	observed	observe	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	SpaceAfter=No
42	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 3569
# text = Document 003003501 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	003003501	003003501	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 3570
# text = Expression of the chemokine receptor BLR2/EBI1 is specifically transactivated by Epstein-Barr virus nuclear antigen 2.
1	Expression	expression	NOUN	NN	Number=Sing	_	_	_	_
2	of	of	ADP	IN	_	_	_	_	_
3	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
4	chemokine	chemokine	NOUN	NN	Number=Sing	_	_	_	_
5	receptor	receptor	NOUN	NN	Number=Sing	_	_	_	_
6	BLR2/EBI1	Blr2/ebi1	NOUN	NN	Number=Sing	_	_	_	_
7	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
8	specifically	specifically	ADV	RB	_	_	_	_	_
9	transactivated	transactivate	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
10	by	by	ADP	IN	_	_	_	_	_
11	Epstein	Epstein	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
12	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
13	Barr	Barr	PROPN	NNP	Number=Sing	_	_	_	_
14	virus	virus	NOUN	NN	Number=Sing	_	_	_	_
15	nuclear	nuclear	ADJ	JJ	Degree=Pos	_	_	_	_
16	antigen	antigen	NOUN	NN	Number=Sing	_	_	_	_
17	2	2	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
18	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 3571
# text = In our attempt to identify chemokine receptors that are related to Burkitt's lymphoma receptor 1 (BLR1) and are expressed in activated lymphocytes we used RT-PCR resulting in the isolation of a cDNA encoding a seven transmembrane receptor termed BLR2.
1	In	in	ADP	IN	_	_	_	_	_
2	our	we	PRON	PRP$	Number=Plur|Person=1|Poss=Yes|PronType=Prs	_	_	_	_
3	attempt	attempt	NOUN	NN	Number=Sing	_	_	_	_
4	to	to	PART	TO	_	_	_	_	_
5	identify	identify	VERB	VB	VerbForm=Inf	_	_	_	_
6	chemokine	chemokine	NOUN	NN	Number=Sing	_	_	_	_
7	receptors	receptor	NOUN	NNS	Number=Plur	_	_	_	_
8	that	that	PRON	WDT	PronType=Rel	_	_	_	_
9	are	be	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
10	related	related	ADJ	JJ	Degree=Pos	_	_	_	_
11	to	to	ADP	IN	_	_	_	_	_
12	Burkitt	Burkitt	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
13	's	's	PART	POS	_	_	_	_	_
14	lymphoma	lymphoma	NOUN	NN	Number=Sing	_	_	_	_
15	receptor	receptor	NOUN	NN	Number=Sing	_	_	_	_
16	1	1	NUM	CD	NumType=Card	_	_	_	_
17	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
18	BLR1	Blr1	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
19	)	)	PUNCT	-RRB-	_	_	_	_	_
20	and	and	CCONJ	CC	_	_	_	_	_
21	are	be	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
22	expressed	express	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
23	in	in	ADP	IN	_	_	_	_	_
24	activated	activated	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
25	lymphocytes	lymphocyte	NOUN	NNS	Number=Plur	_	_	_	_
26	we	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
27	used	use	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
28	RT	Rt	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
29	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
30	PCR	PCR	PROPN	NNP	Number=Sing	_	_	_	_
31	resulting	result	VERB	VBG	VerbForm=Ger	_	_	_	_
32	in	in	ADP	IN	_	_	_	_	_
33	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
34	isolation	isolation	NOUN	NN	Number=Sing	_	_	_	_
35	of	of	ADP	IN	_	_	_	_	_
36	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
37	cDNA	cDNa	NOUN	NN	Number=Sing	_	_	_	_
38	encoding	encod	VERB	VBG	VerbForm=Ger	_	_	_	_
39	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
40	seven	seven	NUM	CD	NumType=Card	_	_	_	_
41	transmembrane	transmembrane	NOUN	NN	Number=Sing	_	_	_	_
42	receptor	receptor	NOUN	NN	Number=Sing	_	_	_	_
43	termed	term	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
44	BLR2	Blr2	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
45	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3572
# text = The protein shows significant sequence similarities to the family of G-protein coupled chemokine receptors and turned out to be identical to the recently described receptor EBI1.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	protein	protein	NOUN	NN	Number=Sing	_	_	_	_
3	shows	show	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
4	significant	significant	ADJ	JJ	Degree=Pos	_	_	_	_
5	sequence	sequence	NOUN	NN	Number=Sing	_	_	_	_
6	similarities	similarity	NOUN	NNS	Number=Plur	_	_	_	_
7	to	to	ADP	IN	_	_	_	_	_
8	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
9	family	family	NOUN	NN	Number=Sing	_	_	_	_
10	of	of	ADP	IN	_	_	_	_	_
11	G-	G-	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
12	protein	protein	NOUN	NN	Number=Sing	_	_	_	_
13	coupled	coupl	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
14	chemokine	chemokine	NOUN	NN	Number=Sing	_	_	_	_
15	receptors	receptor	NOUN	NNS	Number=Plur	_	_	_	_
16	and	and	CCONJ	CC	_	_	_	_	_
17	turned	turn	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
18	out	out	ADP	RP	_	_	_	_	_
19	to	to	PART	TO	_	_	_	_	_
20	be	be	AUX	VB	VerbForm=Inf	_	_	_	_
21	identical	identical	ADJ	JJ	Degree=Pos	_	_	_	_
22	to	to	ADP	IN	_	_	_	_	_
23	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
24	recently	recently	ADV	RB	_	_	_	_	_
25	described	describe	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
26	receptor	receptor	NOUN	NN	Number=Sing	_	_	_	_
27	EBI1	Ebi1	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
28	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3573
# text = Northern blot analysis revealed that BLR2 mRNA could be highly stimulated in mitogen- and anti-CD3-treated peripheral blood lymphocytes.
1	Northern	Northern	ADJ	JJ	Degree=Pos	_	_	_	_
2	blot	blot	NOUN	NN	Number=Sing	_	_	_	_
3	analysis	analysis	NOUN	NN	Number=Sing	_	_	_	_
4	revealed	reveal	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
5	that	that	SCONJ	IN	_	_	_	_	_
6	BLR2	Blr2	NUM	CD	NumType=Card	_	_	_	_
7	mRNA	mRNa	NOUN	NN	Number=Sing	_	_	_	_
8	could	could	AUX	MD	VerbForm=Fin	_	_	_	_
9	be	be	AUX	VB	VerbForm=Inf	_	_	_	_
10	highly	highly	ADV	RB	_	_	_	_	_
11	stimulated	stimulate	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
12	in	in	ADP	IN	_	_	_	_	_
13	mitogen	mitogen	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
14	-	-	PUNCT	,	_	_	_	_	_
15	and	and	CCONJ	CC	_	_	_	_	_
16	anti-CD3	anti-CD3	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
17	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
18	treated	treat	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
19	peripheral	peripheral	ADJ	JJ	Degree=Pos	_	_	_	_
20	blood	blood	NOUN	NN	Number=Sing	_	_	_	_
21	lymphocytes	lymphocyte	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
22	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3574
# text = BLR2-specific mRNA could be detected in all Epstein-Barr virus positive B cell lines.
1	BLR2	Blr2	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
2	-	-	PUNCT	:	_	_	_	_	SpaceAfter=No
3	specific	specific	ADJ	JJ	Degree=Pos	_	_	_	_
4	mRNA	mRNa	NOUN	NN	Number=Sing	_	_	_	_
5	could	could	AUX	MD	VerbForm=Fin	_	_	_	_
6	be	be	AUX	VB	VerbForm=Inf	_	_	_	_
7	detected	detect	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
8	in	in	ADP	IN	_	_	_	_	_
9	all	all	DET	DT	_	_	_	_	_
10	Epstein	Epstein	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
11	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
12	Barr	Barr	PROPN	NNP	Number=Sing	_	_	_	_
13	virus	virus	NOUN	NN	Number=Sing	_	_	_	_
14	positive	positive	ADJ	JJ	Degree=Pos	_	_	_	_
15	B	b	ADJ	JJ	Degree=Pos	_	_	_	_
16	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
17	lines	line	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
18	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3575
# text = We show that transcription of the BLR2 gene could be specifically induced in Epstein-Barr virus negative BL 41 cells via estrogen-mediated activation of Epstein-Barr virus nuclear antigen 2, a key regulator of viral and cellular genes in immortalized B cells.
1	We	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
2	show	show	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
3	that	that	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
4	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
5	of	of	ADP	IN	_	_	_	_	_
6	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
7	BLR2	Blr2	NOUN	NN	Number=Sing	_	_	_	_
8	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
9	could	could	AUX	MD	VerbForm=Fin	_	_	_	_
10	be	be	AUX	VB	VerbForm=Inf	_	_	_	_
11	specifically	specifically	ADV	RB	_	_	_	_	_
12	induced	induce	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
13	in	in	ADP	IN	_	_	_	_	_
14	Epstein	Epstein	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
15	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
16	Barr	Barr	PROPN	NNP	Number=Sing	_	_	_	_
17	virus	virus	NOUN	NN	Number=Sing	_	_	_	_
18	negative	negative	ADJ	JJ	Degree=Pos	_	_	_	_
19	BL	BL	PROPN	NNP	Number=Sing	_	_	_	_
20	41	41	NUM	CD	NumType=Card	_	_	_	_
21	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
22	via	via	ADP	IN	_	_	_	_	_
23	estrogen	estrogen	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
24	-mediated	-mediate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
25	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
26	of	of	ADP	IN	_	_	_	_	_
27	Epstein	Epstein	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
28	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
29	Barr	Barr	PROPN	NNP	Number=Sing	_	_	_	_
30	virus	virus	NOUN	NN	Number=Sing	_	_	_	_
31	nuclear	nuclear	ADJ	JJ	Degree=Pos	_	_	_	_
32	antigen	antigen	NOUN	NN	Number=Sing	_	_	_	_
33	2	2	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
34	,	,	PUNCT	,	_	_	_	_	_
35	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
36	key	key	ADJ	JJ	Degree=Pos	_	_	_	_
37	regulator	regulator	NOUN	NN	Number=Sing	_	_	_	_
38	of	of	ADP	IN	_	_	_	_	_
39	viral	viral	ADJ	JJ	Degree=Pos	_	_	_	_
40	and	and	CCONJ	CC	_	_	_	_	_
41	cellular	cellular	ADJ	JJ	Degree=Pos	_	_	_	_
42	genes	gene	NOUN	NNS	Number=Plur	_	_	_	_
43	in	in	ADP	IN	_	_	_	_	_
44	immortalized	immortalized	ADJ	JJ	Degree=Pos	_	_	_	_
45	B	b	ADJ	JJ	Degree=Pos	_	_	_	_
46	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
47	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3576
# text = Our data suggest an involvement of BLR2 in the regulation of migration in activated lymphocytes and in viral pathogenesis.
1	Our	we	PRON	PRP$	Number=Plur|Person=1|Poss=Yes|PronType=Prs	_	_	_	_
2	data	data	NOUN	NN	Number=Sing	_	_	_	_
3	suggest	suggest	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
4	an	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
5	involvement	involvement	NOUN	NN	Number=Sing	_	_	_	_
6	of	of	ADP	IN	_	_	_	_	_
7	BLR2	BLR2	NUM	CD	NumType=Card	_	_	_	_
8	in	in	ADP	IN	_	_	_	_	_
9	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
10	regulation	regulation	NOUN	NN	Number=Sing	_	_	_	_
11	of	of	ADP	IN	_	_	_	_	_
12	migration	migration	NOUN	NN	Number=Sing	_	_	_	_
13	in	in	ADP	IN	_	_	_	_	_
14	activated	activated	ADJ	JJ	Degree=Pos	_	_	_	_
15	lymphocytes	lymphocyte	NOUN	NNS	Number=Plur	_	_	_	_
16	and	and	CCONJ	CC	_	_	_	_	_
17	in	in	ADP	IN	_	_	_	_	_
18	viral	viral	ADJ	JJ	Degree=Pos	_	_	_	_
19	pathogenesis	pathogenesis	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
20	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 3577
# text = Document 003003502 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	003003502	003003502	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 3578
# text = Functional roles of in vivo footprinted DNA motifs within an alpha-globin enhancer.
1	Functional	functional	ADJ	JJ	Degree=Pos	_	_	_	_
2	roles	role	NOUN	NNS	Number=Plur	_	_	_	_
3	of	of	ADP	IN	_	_	_	_	_
4	in	in	ADP	IN	_	_	_	_	_
5	vivo	vivo	NOUN	NN	Number=Sing	_	_	_	_
6	footprinted	footprint	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
7	DNA	dna	NOUN	NN	Number=Sing	_	_	_	_
8	motifs	motif	NOUN	NNS	Number=Plur	_	_	_	_
9	within	within	ADP	IN	_	_	_	_	_
10	an	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
11	alpha	alpha	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
12	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
13	globin	globin	NOUN	NN	Number=Sing	_	_	_	_
14	enhancer	enhancer	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
15	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3579
# text = Erythroid lineage and developmental stage specificities.
1	Erythroid	Erythroid	ADJ	JJ	Degree=Pos	_	_	_	_
2	lineage	lineage	NOUN	NN	Number=Sing	_	_	_	_
3	and	and	CCONJ	CC	_	_	_	_	_
4	developmental	developmental	ADJ	JJ	Degree=Pos	_	_	_	_
5	stage	stage	NOUN	NN	Number=Sing	_	_	_	_
6	specificities	specificity	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
7	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 3580
# text = Transcriptional regulation of the human alpha-like globin genes, embryonic zeta 2 and adult alpha, during erythroid development is mediated by a distal enhancer, HS-40.
1	Transcriptional	Transcriptional	ADJ	JJ	Degree=Pos	_	_	_	_
2	regulation	regulation	NOUN	NN	Number=Sing	_	_	_	_
3	of	of	ADP	IN	_	_	_	_	_
4	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
5	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
6	alpha	alpha	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
7	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
8	like	like	ADJ	JJ	Degree=Pos	_	_	_	_
9	globin	globin	NOUN	NN	Number=Sing	_	_	_	_
10	genes	gene	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
11	,	,	PUNCT	,	_	_	_	_	_
12	embryonic	embryonic	ADJ	JJ	Degree=Pos	_	_	_	_
13	zeta	zeta	NOUN	NN	Number=Sing	_	_	_	_
14	2	2	NUM	CD	NumType=Card	_	_	_	_
15	and	and	CCONJ	CC	_	_	_	_	_
16	adult	adult	NOUN	NN	Number=Sing	_	_	_	_
17	alpha	alpha	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
18	,	,	PUNCT	,	_	_	_	_	_
19	during	during	ADP	IN	_	_	_	_	_
20	erythroid	erythroid	ADJ	JJ	Degree=Pos	_	_	_	_
21	development	development	NOUN	NN	Number=Sing	_	_	_	_
22	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
23	mediated	mediate	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
24	by	by	ADP	IN	_	_	_	_	_
25	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
26	distal	distal	ADJ	JJ	Degree=Pos	_	_	_	_
27	enhancer	enhancer	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
28	,	,	PUNCT	,	_	_	_	_	_
29	HS	HS	ADV	RB	_	_	_	_	SpaceAfter=No
30	-	-	SYM	SYM	_	_	_	_	SpaceAfter=No
31	40	40	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
32	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3581
# text = Previous protein-DNA binding studies have shown that HS-40 consists of multiple nuclear factor binding motifs that are occupied in vivo in an erythroid lineage- and developmental stage-specific manner.
1	Previous	previous	ADJ	JJ	Degree=Pos	_	_	_	_
2	protein	protein	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
3	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
4	DNA	dna	NOUN	NN	Number=Sing	_	_	_	_
5	binding	binding	VERB	VBG	VerbForm=Ger	_	_	_	_
6	studies	study	NOUN	NNS	Number=Plur	_	_	_	_
7	have	have	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
8	shown	show	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
9	that	that	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
10	HS	HS	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
11	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
12	40	40	NUM	CD	NumType=Card	_	_	_	_
13	consists	consist	NOUN	NNS	Number=Plur	_	_	_	_
14	of	of	ADP	IN	_	_	_	_	_
15	multiple	multiple	ADJ	JJ	Degree=Pos	_	_	_	_
16	nuclear	nuclear	ADJ	JJ	Degree=Pos	_	_	_	_
17	factor	factor	NOUN	NN	Number=Sing	_	_	_	_
18	binding	bind	VERB	VBG	VerbForm=Ger	_	_	_	_
19	motifs	motif	NOUN	NNS	Number=Plur	_	_	_	_
20	that	that	PRON	WDT	PronType=Rel	_	_	_	_
21	are	be	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
22	occupied	occupy	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
23	in	in	ADP	IN	_	_	_	_	_
24	vivo	vivo	NOUN	NN	Number=Sing	_	_	_	_
25	in	in	ADP	IN	_	_	_	_	_
26	an	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
27	erythroid	erythroid	ADJ	JJ	Degree=Pos	_	_	_	_
28	lineage	lineage	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
29	-	-	PUNCT	,	_	_	_	_	_
30	and	and	CCONJ	CC	_	_	_	_	_
31	developmental	developmental	ADJ	JJ	Degree=Pos	_	_	_	_
32	stage	stage	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
33	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
34	specific	specific	ADJ	JJ	Degree=Pos	_	_	_	_
35	manner	manner	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
36	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3582
# text = We have systematically analyzed the functional roles of these factor binding motifs of HS-40 by site-directed mutagenesis and transient expression assay in erythroid cell cultures.
1	We	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
2	have	have	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
3	systematically	systematically	ADV	RB	_	_	_	_	_
4	analyzed	analyze	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
5	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
6	functional	functional	ADJ	JJ	Degree=Pos	_	_	_	_
7	roles	role	NOUN	NNS	Number=Plur	_	_	_	_
8	of	of	ADP	IN	_	_	_	_	_
9	these	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
10	factor	factor	NOUN	NN	Number=Sing	_	_	_	_
11	binding	bind	VERB	VBG	VerbForm=Ger	_	_	_	_
12	motifs	motif	NOUN	NNS	Number=Plur	_	_	_	_
13	of	of	ADP	IN	_	_	_	_	_
14	HS	HS	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
15	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
16	40	40	NUM	CD	NumType=Card	_	_	_	_
17	by	by	ADP	IN	_	_	_	_	_
18	site	site	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
19	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
20	directed	direct	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
21	mutagenesis	mutagenesis	NOUN	NN	Number=Sing	_	_	_	_
22	and	and	CCONJ	CC	_	_	_	_	_
23	transient	transient	ADJ	JJ	Degree=Pos	_	_	_	_
24	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
25	assay	assay	NOUN	NN	Number=Sing	_	_	_	_
26	in	in	ADP	IN	_	_	_	_	_
27	erythroid	erythroid	ADJ	JJ	Degree=Pos	_	_	_	_
28	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
29	cultures	culture	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
30	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3583
# text = Three of these HS-40 enhancer motifs, 5'NF-E2/AP1, GT II, and GATA-1(c), positively regulate the zeta 2-globin promoter activity in embryonic/fetal erythroid K562 cells and the adult alpha-globin promoter activity in adult erythroid MEL cells.
1	Three	three	NUM	CD	NumType=Card	_	_	_	_
2	of	of	ADP	IN	_	_	_	_	_
3	these	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
4	HS	H	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
5	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
6	40	40	NUM	CD	NumType=Card	_	_	_	_
7	enhancer	enhancer	NOUN	NN	Number=Sing	_	_	_	_
8	motifs	motif	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
9	,	,	PUNCT	,	_	_	_	_	_
10	5'NF-	5'NF-	SYM	NFP	_	_	_	_	SpaceAfter=No
11	E2/AP1	E2/AP1	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
12	,	,	PUNCT	,	_	_	_	_	_
13	GT	GT	PROPN	NNP	Number=Sing	_	_	_	_
14	II	II	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
15	,	,	PUNCT	,	_	_	_	_	_
16	and	and	CCONJ	CC	_	_	_	_	_
17	GATA	GATA	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
18	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
19	1	1	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
20	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
21	c	c	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
22	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
23	,	,	PUNCT	,	_	_	_	_	_
24	positively	positively	ADV	RB	_	_	_	_	_
25	regulate	regulate	VERB	VB	VerbForm=Inf	_	_	_	_
26	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
27	zeta	zeta	NOUN	NN	Number=Sing	_	_	_	_
28	2	2	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
29	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
30	globin	globin	NOUN	NN	Number=Sing	_	_	_	_
31	promoter	promoter	NOUN	NN	Number=Sing	_	_	_	_
32	activity	activity	NOUN	NN	Number=Sing	_	_	_	_
33	in	in	ADP	IN	_	_	_	_	_
34	embryonic	embryonic	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
35	/	/	PUNCT	,	_	_	_	_	SpaceAfter=No
36	fetal	fetal	ADJ	JJ	Degree=Pos	_	_	_	_
37	erythroid	erythroid	ADJ	JJ	Degree=Pos	_	_	_	_
38	K562	k562	NUM	CD	NumType=Card	_	_	_	_
39	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
40	and	and	CCONJ	CC	_	_	_	_	_
41	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
42	adult	adult	NOUN	NN	Number=Sing	_	_	_	_
43	alpha	alpha	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
44	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
45	globin	globin	NOUN	NN	Number=Sing	_	_	_	_
46	promoter	promoter	NOUN	NN	Number=Sing	_	_	_	_
47	activity	activity	NOUN	NN	Number=Sing	_	_	_	_
48	in	in	ADP	IN	_	_	_	_	_
49	adult	adult	ADJ	JJ	Degree=Pos	_	_	_	_
50	erythroid	erythroid	ADJ	JJ	Degree=Pos	_	_	_	_
51	MEL	Mel	NOUN	NN	Number=Sing	_	_	_	_
52	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
53	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3584
# text = On the other hand, the 3'NF-E2/AP1 motif is able to exert both positive and negative regulatory effects on the zeta 2-globin promoter activity in K562 cells, and this dual function appears to be modulated through differential binding of the ubiquitous AP1 factors and the erythroid-enriched NF-E2 factor.
1	On	on	ADP	IN	_	_	_	_	_
2	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
3	other	other	ADJ	JJ	Degree=Pos	_	_	_	_
4	hand	hand	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
5	,	,	PUNCT	,	_	_	_	_	_
6	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
7	3'NF	3'nf	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
8	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
9	E2	e2	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
10	/	/	PUNCT	,	_	_	_	_	SpaceAfter=No
11	AP1	Ap1	NUM	CD	NumType=Card	_	_	_	_
12	motif	motif	NOUN	NN	Number=Sing	_	_	_	_
13	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
14	able	able	ADJ	JJ	Degree=Pos	_	_	_	_
15	to	to	PART	TO	_	_	_	_	_
16	exert	exert	VERB	VB	VerbForm=Inf	_	_	_	_
17	both	both	CCONJ	CC	_	_	_	_	_
18	positive	positive	ADJ	JJ	Degree=Pos	_	_	_	_
19	and	and	CCONJ	CC	_	_	_	_	_
20	negative	negative	ADJ	JJ	Degree=Pos	_	_	_	_
21	regulatory	regulatory	ADJ	JJ	Degree=Pos	_	_	_	_
22	effects	effect	NOUN	NNS	Number=Plur	_	_	_	_
23	on	on	ADP	IN	_	_	_	_	_
24	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
25	zeta	zeta	NOUN	NN	Number=Sing	_	_	_	_
26	2	2	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
27	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
28	globin	globin	NOUN	NN	Number=Sing	_	_	_	_
29	promoter	promoter	NOUN	NN	Number=Sing	_	_	_	_
30	activity	activity	NOUN	NN	Number=Sing	_	_	_	_
31	in	in	ADP	IN	_	_	_	_	_
32	K562	K562	NUM	CD	NumType=Card	_	_	_	_
33	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
34	,	,	PUNCT	,	_	_	_	_	_
35	and	and	CCONJ	CC	_	_	_	_	_
36	this	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
37	dual	dual	ADJ	JJ	Degree=Pos	_	_	_	_
38	function	function	NOUN	NN	Number=Sing	_	_	_	_
39	appears	appear	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
40	to	to	PART	TO	_	_	_	_	_
41	be	be	AUX	VB	VerbForm=Inf	_	_	_	_
42	modulated	modulate	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
43	through	through	ADP	IN	_	_	_	_	_
44	differential	differential	ADJ	JJ	Degree=Pos	_	_	_	_
45	binding	binding	NOUN	NN	Number=Sing	_	_	_	_
46	of	of	ADP	IN	_	_	_	_	_
47	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
48	ubiquitous	ubiquitous	ADJ	JJ	Degree=Pos	_	_	_	_
49	AP1	Ap1	NUM	CD	NumType=Card	_	_	_	_
50	factors	factor	NOUN	NNS	Number=Plur	_	_	_	_
51	and	and	CCONJ	CC	_	_	_	_	_
52	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
53	erythroid	erythroid	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
54	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
55	enriched	enrich	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
56	NF	Nf	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
57	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
58	E2	e2	NUM	CD	NumType=Card	_	_	_	_
59	factor	factor	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
60	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3585
# text = Mutation in the GATA-1(d) motif, which exhibits an adult erythroid-specific genomic footprint, decreases the HS-40 enhancer function in dimethyl sulfoxide-induced MEL cells but not in K562 cells.
1	Mutation	Mutation	NOUN	NN	Number=Sing	_	_	_	_
2	in	in	ADP	IN	_	_	_	_	_
3	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
4	GATA	GATA	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
5	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
6	1	1	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
7	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
8	d	would	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
9	)	)	PUNCT	-RRB-	_	_	_	_	_
10	motif	motif	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
11	,	,	PUNCT	,	_	_	_	_	_
12	which	which	PRON	WDT	PronType=Rel	_	_	_	_
13	exhibits	exhibit	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
14	an	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
15	adult	adult	ADJ	JJ	Degree=Pos	_	_	_	_
16	erythroid	erythroid	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
17	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
18	specific	specific	ADJ	JJ	Degree=Pos	_	_	_	_
19	genomic	genomic	ADJ	JJ	Degree=Pos	_	_	_	_
20	footprint	footprint	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
21	,	,	PUNCT	,	_	_	_	_	_
22	decreases	decrease	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
23	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
24	HS	HS	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
25	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
26	40	40	NUM	CD	NumType=Card	_	_	_	_
27	enhancer	enhancer	NOUN	NN	Number=Sing	_	_	_	_
28	function	function	NOUN	NN	Number=Sing	_	_	_	_
29	in	in	ADP	IN	_	_	_	_	_
30	dimethyl	dimethyl	ADJ	JJ	Degree=Pos	_	_	_	_
31	sulfoxide	sulfoxide	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
32	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
33	induced	induce	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
34	MEL	MEL	PROPN	NNP	Number=Sing	_	_	_	_
35	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
36	but	but	CCONJ	CC	_	_	_	_	_
37	not	not	PART	RB	_	_	_	_	_
38	in	in	ADP	IN	_	_	_	_	_
39	K562	K562	NUM	CD	NumType=Card	_	_	_	_
40	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
41	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3586
# text = These studies have defined the regulatory roles of the different HS-40 motifs.
1	These	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
2	studies	study	NOUN	NNS	Number=Plur	_	_	_	_
3	have	have	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
4	defined	define	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
5	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
6	regulatory	regulatory	ADJ	JJ	Degree=Pos	_	_	_	_
7	roles	role	NOUN	NNS	Number=Plur	_	_	_	_
8	of	of	ADP	IN	_	_	_	_	_
9	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
10	different	different	ADJ	JJ	Degree=Pos	_	_	_	_
11	HS	H	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
12	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
13	40	40	NUM	CD	NumType=Card	_	_	_	_
14	motifs	motif	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
15	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3587
# text = The remarkable correlation between genomic footprinting data and the mutagenesis results also suggests that the erythroid lineage- and developmental stage-specific regulation of human alpha-like globin promoters is indeed modulated by stable binding of specific nuclear factors in vivo.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	remarkable	remarkable	ADJ	JJ	Degree=Pos	_	_	_	_
3	correlation	correlation	NOUN	NN	Number=Sing	_	_	_	_
4	between	between	ADP	IN	_	_	_	_	_
5	genomic	genomic	ADJ	JJ	Degree=Pos	_	_	_	_
6	footprinting	footprinting	NOUN	NN	Number=Sing	_	_	_	_
7	data	data	NOUN	NN	Number=Sing	_	_	_	_
8	and	and	CCONJ	CC	_	_	_	_	_
9	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
10	mutagenesis	mutagenesis	ADJ	JJ	Degree=Pos	_	_	_	_
11	results	result	NOUN	NNS	Number=Plur	_	_	_	_
12	also	also	ADV	RB	_	_	_	_	_
13	suggests	suggest	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
14	that	that	SCONJ	IN	_	_	_	_	_
15	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
16	erythroid	erythroid	ADJ	JJ	Degree=Pos	_	_	_	_
17	lineage	lineage	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
18	-	-	PUNCT	,	_	_	_	_	_
19	and	and	CCONJ	CC	_	_	_	_	_
20	developmental	developmental	ADJ	JJ	Degree=Pos	_	_	_	_
21	stage	stage	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
22	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
23	specific	specific	ADJ	JJ	Degree=Pos	_	_	_	_
24	regulation	regulation	NOUN	NN	Number=Sing	_	_	_	_
25	of	of	ADP	IN	_	_	_	_	_
26	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
27	alpha	alpha	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
28	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
29	like	like	ADJ	JJ	Degree=Pos	_	_	_	_
30	globin	globin	NOUN	NN	Number=Sing	_	_	_	_
31	promoters	promoter	NOUN	NNS	Number=Plur	_	_	_	_
32	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
33	indeed	indeed	ADV	RB	_	_	_	_	_
34	modulated	modulate	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
35	by	by	ADP	IN	_	_	_	_	_
36	stable	stable	ADJ	JJ	Degree=Pos	_	_	_	_
37	binding	binding	NOUN	NN	Number=Sing	_	_	_	_
38	of	of	ADP	IN	_	_	_	_	_
39	specific	specific	ADJ	JJ	Degree=Pos	_	_	_	_
40	nuclear	nuclear	ADJ	JJ	Degree=Pos	_	_	_	_
41	factors	factor	NOUN	NNS	Number=Plur	_	_	_	_
42	in	in	ADP	IN	_	_	_	_	_
43	vivo.	vivo.	NOUN	NN	Number=Sing	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 3588
# text = Document 003003503 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	003003503	003003503	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 3589
# text = Expression of c-fos, c-jun and jun B in peripheral blood lymphocytes from young and elderly adults.
1	Expression	expression	NOUN	NN	Number=Sing	_	_	_	_
2	of	of	ADP	IN	_	_	_	_	_
3	c-	c-	PUNCT	:	_	_	_	_	SpaceAfter=No
4	fos	fo	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
5	,	,	PUNCT	,	_	_	_	_	_
6	c-	c-	SYM	NFP	_	_	_	_	SpaceAfter=No
7	jun	jun	NOUN	NN	Number=Sing	_	_	_	_
8	and	and	CCONJ	CC	_	_	_	_	_
9	jun	jun	NOUN	NN	Number=Sing	_	_	_	_
10	B	b	NOUN	NN	Number=Sing	_	_	_	_
11	in	in	ADP	IN	_	_	_	_	_
12	peripheral	peripheral	ADJ	JJ	Degree=Pos	_	_	_	_
13	blood	blood	NOUN	NN	Number=Sing	_	_	_	_
14	lymphocytes	lymphocyte	NOUN	NNS	Number=Plur	_	_	_	_
15	from	from	ADP	IN	_	_	_	_	_
16	young	young	ADJ	JJ	Degree=Pos	_	_	_	_
17	and	and	CCONJ	CC	_	_	_	_	_
18	elderly	elderly	ADJ	JJ	Degree=Pos	_	_	_	_
19	adults	adult	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
20	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 3590
# text = The expression of c-fos, c-jun and jun B proto-oncogenes was studied in phytohemagglutinin (PHA) activated peripheral blood lymphocytes (PBL) from young and aged humans.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
3	of	of	ADP	IN	_	_	_	_	_
4	c-	c-	PUNCT	:	_	_	_	_	SpaceAfter=No
5	fos	fo	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
6	,	,	PUNCT	,	_	_	_	_	_
7	c-	c-	SYM	NFP	_	_	_	_	SpaceAfter=No
8	jun	jun	NOUN	NN	Number=Sing	_	_	_	_
9	and	and	CCONJ	CC	_	_	_	_	_
10	jun	jun	NOUN	NN	Number=Sing	_	_	_	_
11	B	b	NOUN	NN	Number=Sing	_	_	_	_
12	proto	proto	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
13	-oncogenes	-oncogene	NOUN	NNS	Number=Plur	_	_	_	_
14	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
15	studied	study	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
16	in	in	ADP	IN	_	_	_	_	_
17	phytohemagglutinin	phytohemagglutinin	NOUN	NN	Number=Sing	_	_	_	_
18	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
19	PHA	PHA	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
20	)	)	PUNCT	-RRB-	_	_	_	_	_
21	activated	activate	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
22	peripheral	peripheral	ADJ	JJ	Degree=Pos	_	_	_	_
23	blood	blood	NOUN	NN	Number=Sing	_	_	_	_
24	lymphocytes	lymphocyte	NOUN	NNS	Number=Plur	_	_	_	_
25	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
26	PBL	PBL	INTJ	UH	_	_	_	_	SpaceAfter=No
27	)	)	PUNCT	-RRB-	_	_	_	_	_
28	from	from	ADP	IN	_	_	_	_	_
29	young	young	ADJ	JJ	Degree=Pos	_	_	_	_
30	and	and	CCONJ	CC	_	_	_	_	_
31	aged	aged	ADJ	JJ	Degree=Pos	_	_	_	_
32	humans	human	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
33	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3591
# text = Specific mRNAs for c-fos and c-jun were detectable within 30 min after cell activation and reached maximal levels within 2 h.
1	Specific	specific	ADJ	JJ	Degree=Pos	_	_	_	_
2	mRNAs	mRNA	NOUN	NNS	Number=Plur	_	_	_	_
3	for	for	ADP	IN	_	_	_	_	_
4	c	c	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
5	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
6	fos	fo	NOUN	NNS	Number=Plur	_	_	_	_
7	and	and	CCONJ	CC	_	_	_	_	_
8	c-	c-	SYM	NFP	_	_	_	_	SpaceAfter=No
9	jun	jun	NOUN	NN	Number=Sing	_	_	_	_
10	were	be	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
11	detectable	detectable	ADJ	JJ	Degree=Pos	_	_	_	_
12	within	within	ADP	IN	_	_	_	_	_
13	30	30	NUM	CD	NumType=Card	_	_	_	_
14	min	min	NOUN	NNS	Number=Plur	_	_	_	_
15	after	after	ADP	IN	_	_	_	_	_
16	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
17	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
18	and	and	CCONJ	CC	_	_	_	_	_
19	reached	reach	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
20	maximal	maximal	ADJ	JJ	Degree=Pos	_	_	_	_
21	levels	level	NOUN	NNS	Number=Plur	_	_	_	_
22	within	within	ADP	IN	_	_	_	_	_
23	2	2	NUM	CD	NumType=Card	_	_	_	_
24	h	h	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
25	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3592
# text = Both c-fos and jun B mRNAs decreased to pre-activation levels within 6 h, while c-jun mRNA remained elevated.
1	Both	both	DET	DT	_	_	_	_	_
2	c-	c-	SYM	NFP	_	_	_	_	SpaceAfter=No
3	fos	fo	NOUN	NNS	Number=Plur	_	_	_	_
4	and	and	CCONJ	CC	_	_	_	_	_
5	jun	jun	NOUN	NN	Number=Sing	_	_	_	_
6	B	b	NOUN	NN	Number=Sing	_	_	_	_
7	mRNAs	mRNA	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
8	decreased	decrease	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
9	to	to	ADP	IN	_	_	_	_	_
10	pre-activation	pre-activation	NOUN	NN	Number=Sing	_	_	_	_
11	levels	level	NOUN	NNS	Number=Plur	_	_	_	_
12	within	within	ADP	IN	_	_	_	_	_
13	6	6	NUM	CD	NumType=Card	_	_	_	_
14	h	h	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
15	,	,	PUNCT	,	_	_	_	_	_
16	while	while	SCONJ	IN	_	_	_	_	_
17	c-	c-	SYM	NFP	_	_	_	_	SpaceAfter=No
18	jun	jun	PROPN	NNP	Number=Sing	_	_	_	_
19	mRNA	mRNa	PROPN	NNP	Number=Sing	_	_	_	_
20	remained	remain	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
21	elevated	elevate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	SpaceAfter=No
22	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3593
# text = In PHA-activated PBL, no age-related differences were observed in c-fos or jun B mRNA expression.
1	In	in	ADP	IN	_	_	_	_	_
2	PHA	PHA	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
3	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
4	activated	activate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
5	PBL	pBl	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
6	,	,	PUNCT	,	_	_	_	_	_
7	no	no	DET	DT	_	_	_	_	_
8	age	age	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
9	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
10	related	related	ADJ	JJ	Degree=Pos	_	_	_	_
11	differences	difference	NOUN	NNS	Number=Plur	_	_	_	_
12	were	be	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
13	observed	observe	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
14	in	in	ADP	IN	_	_	_	_	_
15	c	c	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
16	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
17	fos	fo	NOUN	NNS	Number=Plur	_	_	_	_
18	or	or	CCONJ	CC	_	_	_	_	_
19	jun	jun	VERB	VB	VerbForm=Inf	_	_	_	_
20	B	b	PROPN	NNP	Number=Sing	_	_	_	_
21	mRNA	mRNa	PROPN	NNP	Number=Sing	_	_	_	_
22	expression	expression	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
23	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3594
# text = However, c-jun mRNA levels decreased significantly (1.73 +/- 0.08 vs. 1.16 +/- 0.09 arbitrary units, P < 0.01, young vs. old) in PBL from elderly individuals activated with PHA.
1	However	however	ADV	RB	_	_	_	_	SpaceAfter=No
2	,	,	PUNCT	,	_	_	_	_	_
3	c-	c-	SYM	NFP	_	_	_	_	SpaceAfter=No
4	jun	jun	ADJ	JJ	Degree=Pos	_	_	_	_
5	mRNA	mRNa	NOUN	NN	Number=Sing	_	_	_	_
6	levels	level	NOUN	NNS	Number=Plur	_	_	_	_
7	decreased	decrease	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
8	significantly	significantly	ADV	RB	_	_	_	_	_
9	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
10	1.73	1.73	NUM	CD	NumType=Card	_	_	_	_
11	+/-	+/-	SYM	SYM	_	_	_	_	_
12	0.08	0.08	NUM	CD	NumType=Card	_	_	_	_
13	vs.	versus	ADP	IN	_	_	_	_	_
14	1.16	1.16	NUM	CD	NumType=Card	_	_	_	_
15	+/-	+/-	SYM	SYM	_	_	_	_	_
16	0.09	0.09	NUM	CD	NumType=Card	_	_	_	_
17	arbitrary	arbitrary	ADJ	JJ	Degree=Pos	_	_	_	_
18	units	unit	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
19	,	,	PUNCT	,	_	_	_	_	_
20	P	P	PROPN	NNP	Number=Sing	_	_	_	_
21	<	<	PUNCT	-LRB-	_	_	_	_	_
22	0.01	0.01	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
23	,	,	PUNCT	,	_	_	_	_	_
24	young	young	ADJ	JJ	Degree=Pos	_	_	_	_
25	vs.	vs.	CCONJ	CC	_	_	_	_	_
26	old	old	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
27	)	)	PUNCT	-RRB-	_	_	_	_	_
28	in	in	ADP	IN	_	_	_	_	_
29	PBL	PBL	PROPN	NNP	Number=Sing	_	_	_	_
30	from	from	ADP	IN	_	_	_	_	_
31	elderly	elderly	ADJ	JJ	Degree=Pos	_	_	_	_
32	individuals	individual	NOUN	NNS	Number=Plur	_	_	_	_
33	activated	activate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
34	with	with	ADP	IN	_	_	_	_	_
35	PHA	PHa	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
36	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3595
# text = Because previous work has demonstrated that T cells from elderly individuals may display normal proliferative responses when activated via the anti-CD2 pathway, c-jun and jun B mRNA expression was also studied in anti-CD2-activated purified T cells.
1	Because	because	SCONJ	IN	_	_	_	_	_
2	previous	previous	ADJ	JJ	Degree=Pos	_	_	_	_
3	work	work	NOUN	NN	Number=Sing	_	_	_	_
4	has	have	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
5	demonstrated	demonstrate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
6	that	that	SCONJ	IN	_	_	_	_	_
7	T	t	PROPN	NNP	Number=Sing	_	_	_	_
8	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
9	from	from	ADP	IN	_	_	_	_	_
10	elderly	elderly	ADJ	JJ	Degree=Pos	_	_	_	_
11	individuals	individual	NOUN	NNS	Number=Plur	_	_	_	_
12	may	may	AUX	MD	VerbForm=Fin	_	_	_	_
13	display	display	VERB	VB	VerbForm=Inf	_	_	_	_
14	normal	normal	ADJ	JJ	Degree=Pos	_	_	_	_
15	proliferative	proliferative	ADJ	JJ	Degree=Pos	_	_	_	_
16	responses	response	NOUN	NNS	Number=Plur	_	_	_	_
17	when	when	ADV	WRB	PronType=Int	_	_	_	_
18	activated	activate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
19	via	via	ADP	IN	_	_	_	_	_
20	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
21	anti-CD2	anti-cd2	NOUN	NN	Number=Sing	_	_	_	_
22	pathway	pathway	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
23	,	,	PUNCT	,	_	_	_	_	_
24	c-	c-	SYM	NFP	_	_	_	_	SpaceAfter=No
25	jun	jun	NOUN	NN	Number=Sing	_	_	_	_
26	and	and	CCONJ	CC	_	_	_	_	_
27	jun	jun	NOUN	NN	Number=Sing	_	_	_	_
28	B	b	PROPN	NNP	Number=Sing	_	_	_	_
29	mRNA	mRNa	PROPN	NNP	Number=Sing	_	_	_	_
30	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
31	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
32	also	also	ADV	RB	_	_	_	_	_
33	studied	study	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
34	in	in	ADP	IN	_	_	_	_	_
35	anti-CD2	anti-CD2	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
36	-activated	-activate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
37	purified	purify	ADJ	JJ	Degree=Pos	_	_	_	_
38	T	t	PROPN	NNP	Number=Sing	_	_	_	_
39	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
40	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3596
# text = No age-related differences were found in the expression of either of these two proto-oncogenes by anti-CD2 activated T cells.
1	No	no	DET	DT	_	_	_	_	_
2	age	age	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
3	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
4	related	related	ADJ	JJ	Degree=Pos	_	_	_	_
5	differences	difference	NOUN	NNS	Number=Plur	_	_	_	_
6	were	be	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
7	found	find	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
8	in	in	ADP	IN	_	_	_	_	_
9	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
10	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
11	of	of	ADP	IN	_	_	_	_	_
12	either	either	DET	DT	_	_	_	_	_
13	of	of	ADP	IN	_	_	_	_	_
14	these	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
15	two	two	NUM	CD	NumType=Card	_	_	_	_
16	proto	proto	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
17	-oncogenes	-oncogene	NOUN	NNS	Number=Plur	_	_	_	_
18	by	by	ADP	IN	_	_	_	_	_
19	anti-CD2	anti-CD2	NUM	CD	NumType=Card	_	_	_	_
20	activated	activate	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
21	T	t	NUM	CD	NumType=Card	_	_	_	_
22	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
23	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3597
# text = These results suggest that the decreased IL-2 production and proliferative response displayed by PHA-activated PBL from elderly adults may be related to age-related changes in c-jun mRNA expression and in the ratio of c-fos to c-jun mRNA.
1	These	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
2	results	result	NOUN	NNS	Number=Plur	_	_	_	_
3	suggest	suggest	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
4	that	that	SCONJ	IN	_	_	_	_	_
5	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
6	decreased	decrease	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
7	IL	Il	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
8	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
9	2	2	NUM	CD	NumType=Card	_	_	_	_
10	production	production	NOUN	NN	Number=Sing	_	_	_	_
11	and	and	CCONJ	CC	_	_	_	_	_
12	proliferative	proliferative	ADJ	JJ	Degree=Pos	_	_	_	_
13	response	response	NOUN	NN	Number=Sing	_	_	_	_
14	displayed	display	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
15	by	by	ADP	IN	_	_	_	_	_
16	PHA	PHA	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
17	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
18	activated	activate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
19	PBL	pBl	NOUN	NN	Number=Sing	_	_	_	_
20	from	from	ADP	IN	_	_	_	_	_
21	elderly	elderly	ADJ	JJ	Degree=Pos	_	_	_	_
22	adults	adult	NOUN	NNS	Number=Plur	_	_	_	_
23	may	may	AUX	MD	VerbForm=Fin	_	_	_	_
24	be	be	AUX	VB	VerbForm=Inf	_	_	_	_
25	related	related	ADJ	JJ	Degree=Pos	_	_	_	_
26	to	to	ADP	IN	_	_	_	_	_
27	age	age	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
28	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
29	related	related	ADJ	JJ	Degree=Pos	_	_	_	_
30	changes	change	NOUN	NNS	Number=Plur	_	_	_	_
31	in	in	ADP	IN	_	_	_	_	_
32	c-	c-	SYM	NFP	_	_	_	_	SpaceAfter=No
33	jun	jun	NOUN	NN	Number=Sing	_	_	_	_
34	mRNA	mRNa	NOUN	NN	Number=Sing	_	_	_	_
35	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
36	and	and	CCONJ	CC	_	_	_	_	_
37	in	in	ADP	IN	_	_	_	_	_
38	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
39	ratio	ratio	NOUN	NN	Number=Sing	_	_	_	_
40	of	of	ADP	IN	_	_	_	_	_
41	c	c	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
42	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
43	fos	fo	NOUN	NNS	Number=Plur	_	_	_	_
44	to	to	ADP	IN	_	_	_	_	_
45	c-	c-	SYM	NFP	_	_	_	_	SpaceAfter=No
46	jun	jun	PROPN	NNP	Number=Sing	_	_	_	_
47	mRNA.	mRNA.	PROPN	NNP	Number=Sing	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 3598
# text = Document 003003506 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	003003506	003003506	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 3599
# text = Lineage-specific activation of STAT3 by interferon-gamma in human neutrophils.
1	Lineage	Lineage	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
2	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
3	specific	specific	ADJ	JJ	Degree=Pos	_	_	_	_
4	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
5	of	of	ADP	IN	_	_	_	_	_
6	STAT3	STAT3	NUM	CD	NumType=Card	_	_	_	_
7	by	by	ADP	IN	_	_	_	_	_
8	interferon	interferon	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
9	-	-	PUNCT	:	_	_	_	_	SpaceAfter=No
10	gamma	gamma	NOUN	NN	Number=Sing	_	_	_	_
11	in	in	ADP	IN	_	_	_	_	_
12	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
13	neutrophils	neutrophil	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
14	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 3600
# text = Binding of interferon-gamma (IFN-gamma) to its heterodimeric receptor induces activation of the tyrosine kinases JAK1 and JAK2 followed by tyrosine phosphorylation of STAT1alpha.
1	Binding	binding	NOUN	NN	Number=Sing	_	_	_	_
2	of	of	ADP	IN	_	_	_	_	_
3	interferon	interferon	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
4	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
5	gamma	gamma	NOUN	NN	Number=Sing	_	_	_	_
6	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
7	IFN	Ifn	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
8	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
9	gamma	gamma	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
10	)	)	PUNCT	-RRB-	_	_	_	_	_
11	to	to	ADP	IN	_	_	_	_	_
12	its	its	PRON	PRP$	Gender=Neut|Number=Sing|Person=3|Poss=Yes|PronType=Prs	_	_	_	_
13	heterodimeric	heterodimeric	ADJ	JJ	Degree=Pos	_	_	_	_
14	receptor	receptor	NOUN	NN	Number=Sing	_	_	_	_
15	induces	induce	NOUN	NNS	Number=Plur	_	_	_	_
16	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
17	of	of	ADP	IN	_	_	_	_	_
18	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
19	tyrosine	tyrosine	NOUN	NN	Number=Sing	_	_	_	_
20	kinases	kinase	NOUN	NNS	Number=Plur	_	_	_	_
21	JAK1	JAK1	NUM	CD	NumType=Card	_	_	_	_
22	and	and	CCONJ	CC	_	_	_	_	_
23	JAK2	JAK2	NUM	CD	NumType=Card	_	_	_	_
24	followed	follow	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
25	by	by	ADP	IN	_	_	_	_	_
26	tyrosine	tyrosine	NOUN	NN	Number=Sing	_	_	_	_
27	phosphorylation	phosphorylation	NOUN	NN	Number=Sing	_	_	_	_
28	of	of	ADP	IN	_	_	_	_	_
29	STAT1	STAT1	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
30	alpha	alpha	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
31	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3601
# text = Selective activation of STAT1alpha at the IFN-gamma receptor is achieved by specific interaction between a cytosolic tyrosine motif including Y440 in the IFN-gamma receptor alpha-chain and the SH2 domain of STAT1alpha.
1	Selective	selective	ADJ	JJ	Degree=Pos	_	_	_	_
2	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
3	of	of	ADP	IN	_	_	_	_	_
4	STAT1	STAT1	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
5	alpha	alpha	NOUN	NN	Number=Sing	_	_	_	_
6	at	at	ADP	IN	_	_	_	_	_
7	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
8	IFN	Ifn	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
9	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
10	gamma	gamma	NOUN	NN	Number=Sing	_	_	_	_
11	receptor	receptor	NOUN	NN	Number=Sing	_	_	_	_
12	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
13	achieved	achieve	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
14	by	by	ADP	IN	_	_	_	_	_
15	specific	specific	ADJ	JJ	Degree=Pos	_	_	_	_
16	interaction	interaction	NOUN	NN	Number=Sing	_	_	_	_
17	between	between	ADP	IN	_	_	_	_	_
18	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
19	cytosolic	cytosolic	ADJ	JJ	Degree=Pos	_	_	_	_
20	tyrosine	tyrosine	NOUN	NN	Number=Sing	_	_	_	_
21	motif	motif	SCONJ	IN	_	_	_	_	_
22	including	include	VERB	VBG	VerbForm=Ger	_	_	_	_
23	Y440	Y440	NUM	CD	NumType=Card	_	_	_	_
24	in	in	ADP	IN	_	_	_	_	_
25	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
26	IFN	Ifn	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
27	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
28	gamma	gamma	NOUN	NN	Number=Sing	_	_	_	_
29	receptor	receptor	NOUN	NN	Number=Sing	_	_	_	_
30	alpha-	alpha-	SYM	NFP	_	_	_	_	SpaceAfter=No
31	chain	chain	NOUN	NN	Number=Sing	_	_	_	_
32	and	and	CCONJ	CC	_	_	_	_	_
33	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
34	SH2	Sh2	NOUN	NN	Number=Sing	_	_	_	_
35	domain	domain	NOUN	NN	Number=Sing	_	_	_	_
36	of	of	ADP	IN	_	_	_	_	_
37	STAT1	STAT1	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
38	alpha	alpha	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
39	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3602
# text = We demonstrate that, in addition to STAT1alpha, STAT3 is also activated by IFN-gamma in human neutrophils.
1	We	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
2	demonstrate	demonstrate	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
3	that	that	PRON	DT	Number=Sing|PronType=Dem	_	_	_	SpaceAfter=No
4	,	,	PUNCT	,	_	_	_	_	_
5	in	in	ADP	IN	_	_	_	_	_
6	addition	addition	NOUN	NN	Number=Sing	_	_	_	_
7	to	to	ADP	IN	_	_	_	_	_
8	STAT1	STAT1	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
9	alpha	alpha	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
10	,	,	PUNCT	,	_	_	_	_	_
11	STAT3	STAT3	NOUN	NN	Number=Sing	_	_	_	_
12	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
13	also	also	ADV	RB	_	_	_	_	_
14	activated	activate	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
15	by	by	ADP	IN	_	_	_	_	_
16	IFN	IFN	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
17	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
18	gamma	gamma	NOUN	NN	Number=Sing	_	_	_	_
19	in	in	ADP	IN	_	_	_	_	_
20	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
21	neutrophils	neutrophil	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
22	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3603
# text = The activation of STAT3 was not found in human eosinophils, monocytes, and HL-60 cells, although the STAT3 protein was expressed in these cells.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
3	of	of	ADP	IN	_	_	_	_	_
4	STAT3	STAT3	NOUN	NN	Number=Sing	_	_	_	_
5	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
6	not	not	PART	RB	_	_	_	_	_
7	found	find	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
8	in	in	ADP	IN	_	_	_	_	_
9	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
10	eosinophils	eosinophil	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
11	,	,	PUNCT	,	_	_	_	_	_
12	monocytes	monocyte	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
13	,	,	PUNCT	,	_	_	_	_	_
14	and	and	CCONJ	CC	_	_	_	_	_
15	HL	HL	ADV	RB	_	_	_	_	SpaceAfter=No
16	-	-	SYM	SYM	_	_	_	_	SpaceAfter=No
17	60	60	NUM	CD	NumType=Card	_	_	_	_
18	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
19	,	,	PUNCT	,	_	_	_	_	_
20	although	although	SCONJ	IN	_	_	_	_	_
21	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
22	STAT3	STAT3	NOUN	NN	Number=Sing	_	_	_	_
23	protein	protein	NOUN	NN	Number=Sing	_	_	_	_
24	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
25	expressed	express	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
26	in	in	ADP	IN	_	_	_	_	_
27	these	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
28	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
29	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3604
# text = The cell type-specific activation of STAT3 by IFN-gamma was also observed in neutrophils that are differentiated in vitro from human CD34+ hematopoietic stem cells.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
3	type	type	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
4	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
5	specific	specific	ADJ	JJ	Degree=Pos	_	_	_	_
6	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
7	of	of	ADP	IN	_	_	_	_	_
8	STAT3	STAT3	NUM	CD	NumType=Card	_	_	_	_
9	by	by	ADP	IN	_	_	_	_	_
10	IFN	IFN	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
11	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
12	gamma	gamma	NOUN	NN	Number=Sing	_	_	_	_
13	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
14	also	also	ADV	RB	_	_	_	_	_
15	observed	observe	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
16	in	in	ADP	IN	_	_	_	_	_
17	neutrophils	neutrophil	NOUN	NNS	Number=Plur	_	_	_	_
18	that	that	PRON	WDT	PronType=Rel	_	_	_	_
19	are	be	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
20	differentiated	differentiate	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
21	in	in	ADP	IN	_	_	_	_	_
22	vitro	vitro	NOUN	NN	Number=Sing	_	_	_	_
23	from	from	ADP	IN	_	_	_	_	_
24	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
25	CD34	CD34	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
26	+	+	SYM	SYM	_	_	_	_	_
27	hematopoietic	hematopoietic	ADJ	JJ	Degree=Pos	_	_	_	_
28	stem	stem	NOUN	NN	Number=Sing	_	_	_	_
29	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
30	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3605
# text = These results indicate that a single cytokine receptor can activate different
1	These	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
2	results	result	NOUN	NNS	Number=Plur	_	_	_	_
3	indicate	indicate	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
4	that	that	SCONJ	IN	_	_	_	_	_
5	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
6	single	single	ADJ	JJ	Degree=Pos	_	_	_	_
7	cytokine	cytokine	NOUN	NN	Number=Sing	_	_	_	_
8	receptor	receptor	NOUN	NN	Number=Sing	_	_	_	_
9	can	can	AUX	MD	VerbForm=Fin	_	_	_	_
10	activate	activate	VERB	VB	VerbForm=Inf	_	_	_	_
11	different	different	ADJ	JJ	Degree=Pos	_	_	_	_

# sent_id = 3606
# text = STAT family members in a cell-specific manner, which might result in cell-specific gene transcription.
1	STAT	Stat	ADJ	JJ	Degree=Pos	_	_	_	_
2	family	family	NOUN	NN	Number=Sing	_	_	_	_
3	members	member	NOUN	NNS	Number=Plur	_	_	_	_
4	in	in	ADP	IN	_	_	_	_	_
5	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
6	cell	cell	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
7	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
8	specific	specific	ADJ	JJ	Degree=Pos	_	_	_	_
9	manner	manner	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
10	,	,	PUNCT	,	_	_	_	_	_
11	which	which	PRON	WDT	PronType=Rel	_	_	_	_
12	might	might	AUX	MD	VerbForm=Fin	_	_	_	_
13	result	result	VERB	VB	VerbForm=Inf	_	_	_	_
14	in	in	ADP	IN	_	_	_	_	_
15	cell	cell	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
16	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
17	specific	specific	ADJ	JJ	Degree=Pos	_	_	_	_
18	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
19	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
20	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 3607
# text = Document 003003508 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	003003508	003003508	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 3608
# text = Identification and purification of human Stat proteins activated in response to interleukin-2.
1	Identification	identification	NOUN	NN	Number=Sing	_	_	_	_
2	and	and	CCONJ	CC	_	_	_	_	_
3	purification	purification	NOUN	NN	Number=Sing	_	_	_	_
4	of	of	ADP	IN	_	_	_	_	_
5	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
6	Stat	Stat	PROPN	NNP	Number=Sing	_	_	_	_
7	proteins	protein	NOUN	NNS	Number=Plur	_	_	_	_
8	activated	activate	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
9	in	in	ADP	IN	_	_	_	_	_
10	response	response	NOUN	NN	Number=Sing	_	_	_	_
11	to	to	PART	TO	_	_	_	_	_
12	interleukin	interleukin	VERB	VB	VerbForm=Inf	_	_	_	SpaceAfter=No
13	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
14	2	2	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
15	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 3609
# text = A key cytokine induced during the immune response is IL-2.
1	A	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
2	key	key	ADJ	JJ	Degree=Pos	_	_	_	_
3	cytokine	cytokine	NOUN	NN	Number=Sing	_	_	_	_
4	induced	induce	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
5	during	during	ADP	IN	_	_	_	_	_
6	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
7	immune	immune	ADJ	JJ	Degree=Pos	_	_	_	_
8	response	response	NOUN	NN	Number=Sing	_	_	_	_
9	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
10	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
11	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
12	2	2	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
13	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3610
# text = Following T cell activation, the genes encoding IL-2 and the various chains of its receptor are transcriptionally induced.
1	Following	follow	VERB	VBG	VerbForm=Ger	_	_	_	_
2	T	t	PROPN	NNP	Number=Sing	_	_	_	_
3	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
4	activation	activation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
5	,	,	PUNCT	,	_	_	_	_	_
6	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
7	genes	gene	NOUN	NNS	Number=Plur	_	_	_	_
8	encoding	encod	VERB	VBG	VerbForm=Ger	_	_	_	_
9	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
10	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
11	2	2	NUM	CD	NumType=Card	_	_	_	_
12	and	and	CCONJ	CC	_	_	_	_	_
13	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
14	various	various	ADJ	JJ	Degree=Pos	_	_	_	_
15	chains	chain	NOUN	NNS	Number=Plur	_	_	_	_
16	of	of	ADP	IN	_	_	_	_	_
17	its	its	PRON	PRP$	Gender=Neut|Number=Sing|Person=3|Poss=Yes|PronType=Prs	_	_	_	_
18	receptor	receptor	NOUN	NN	Number=Sing	_	_	_	_
19	are	be	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
20	transcriptionally	transcriptionally	ADV	RB	_	_	_	_	_
21	induced	induce	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	SpaceAfter=No
22	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3611
# text = In turn, secreted IL-2 serves to stimulate the proliferation and differentiation of T lymphocytes.
1	In	in	ADP	IN	_	_	_	_	_
2	turn	turn	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
3	,	,	PUNCT	,	_	_	_	_	_
4	secreted	secret	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
5	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
6	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
7	2	2	NUM	CD	NumType=Card	_	_	_	_
8	serves	serf	NOUN	NNS	Number=Plur	_	_	_	_
9	to	to	PART	TO	_	_	_	_	_
10	stimulate	stimulate	VERB	VB	VerbForm=Inf	_	_	_	_
11	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
12	proliferation	proliferation	NOUN	NN	Number=Sing	_	_	_	_
13	and	and	CCONJ	CC	_	_	_	_	_
14	differentiation	differentiation	NOUN	NN	Number=Sing	_	_	_	_
15	of	of	ADP	IN	_	_	_	_	_
16	T	t	PROPN	NNP	Number=Sing	_	_	_	_
17	lymphocytes	lymphocyte	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
18	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3612
# text = Several recent studies have implicated Jak kinases in the signaling pathway induced by IL-2.
1	Several	several	ADJ	JJ	Degree=Pos	_	_	_	_
2	recent	recent	ADJ	JJ	Degree=Pos	_	_	_	_
3	studies	study	NOUN	NNS	Number=Plur	_	_	_	_
4	have	have	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
5	implicated	implicate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
6	Jak	Jak	PROPN	NNP	Number=Sing	_	_	_	_
7	kinases	kinase	NOUN	NNS	Number=Plur	_	_	_	_
8	in	in	ADP	IN	_	_	_	_	_
9	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
10	signaling	signaling	NOUN	NN	Number=Sing	_	_	_	_
11	pathway	pathway	NOUN	NN	Number=Sing	_	_	_	_
12	induced	induce	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
13	by	by	ADP	IN	_	_	_	_	_
14	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
15	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
16	2	2	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
17	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3613
# text = Following this lead, we set out to identify transcription factors induced in response to IL-2.
1	Following	follow	VERB	VBG	VerbForm=Ger	_	_	_	_
2	this	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
3	lead	lead	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
4	,	,	PUNCT	,	_	_	_	_	_
5	we	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
6	set	set	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
7	out	out	ADP	RP	_	_	_	_	_
8	to	to	PART	TO	_	_	_	_	_
9	identify	identify	VERB	VB	VerbForm=Inf	_	_	_	_
10	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
11	factors	factor	NOUN	NNS	Number=Plur	_	_	_	_
12	induced	induce	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
13	in	in	ADP	IN	_	_	_	_	_
14	response	response	NOUN	NN	Number=Sing	_	_	_	_
15	to	to	ADP	IN	_	_	_	_	_
16	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
17	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
18	2	2	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
19	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3614
# text = Human peripheral blood lymphocytes were observed to contain several IL-2-inducible DNA binding activities.
1	Human	human	ADJ	JJ	Degree=Pos	_	_	_	_
2	peripheral	peripheral	ADJ	JJ	Degree=Pos	_	_	_	_
3	blood	blood	NOUN	NN	Number=Sing	_	_	_	_
4	lymphocytes	lymphocyte	NOUN	NNS	Number=Plur	_	_	_	_
5	were	be	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
6	observed	observe	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
7	to	to	PART	TO	_	_	_	_	_
8	contain	contain	VERB	VB	VerbForm=Inf	_	_	_	_
9	several	several	ADJ	JJ	Degree=Pos	_	_	_	_
10	IL	Il	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
11	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
12	2	2	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
13	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
14	inducible	inducible	ADJ	JJ	Degree=Pos	_	_	_	_
15	DNA	dna	NOUN	NN	Number=Sing	_	_	_	_
16	binding	bind	VERB	VBG	VerbForm=Ger	_	_	_	_
17	activities	activity	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
18	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3615
# text = Similar activities were also observed in a transformed human lymphocyte line, termed YT.
1	Similar	similar	ADJ	JJ	Degree=Pos	_	_	_	_
2	activities	activity	NOUN	NNS	Number=Plur	_	_	_	_
3	were	be	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
4	also	also	ADV	RB	_	_	_	_	_
5	observed	observe	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
6	in	in	ADP	IN	_	_	_	_	_
7	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
8	transformed	transform	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
9	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
10	lymphocyte	lymphocyte	NOUN	NN	Number=Sing	_	_	_	_
11	line	line	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
12	,	,	PUNCT	,	_	_	_	_	_
13	termed	term	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
14	YT	YT	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
15	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3616
# text = We have purified these activities and found that the principal IL-2-inducible component bears significant relatedness to a prolactin-induced transcription factor first identified in sheep mammary gland tissue.
1	We	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
2	have	have	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
3	purified	purify	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
4	these	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
5	activities	activity	NOUN	NNS	Number=Plur	_	_	_	_
6	and	and	CCONJ	CC	_	_	_	_	_
7	found	find	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
8	that	that	SCONJ	IN	_	_	_	_	_
9	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
10	principal	principal	NOUN	NN	Number=Sing	_	_	_	_
11	IL	Il	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
12	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
13	2	2	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
14	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
15	inducible	inducible	ADJ	JJ	Degree=Pos	_	_	_	_
16	component	component	ADJ	JJ	Degree=Pos	_	_	_	_
17	bears	bear	NOUN	NNS	Number=Plur	_	_	_	_
18	significant	significant	ADJ	JJ	Degree=Pos	_	_	_	_
19	relatedness	relatedness	NOUN	NN	Number=Sing	_	_	_	_
20	to	to	ADP	IN	_	_	_	_	_
21	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
22	prolactin-	prolactin-	SYM	SYM	_	_	_	_	SpaceAfter=No
23	induced	induce	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
24	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
25	factor	factor	NOUN	NN	Number=Sing	_	_	_	_
26	first	first	ADV	RB	_	_	_	_	_
27	identified	identify	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
28	in	in	ADP	IN	_	_	_	_	_
29	sheep	sheep	ADJ	JJ	Degree=Pos	_	_	_	_
30	mammary	mammary	ADJ	JJ	Degree=Pos	_	_	_	_
31	gland	gland	NOUN	NN	Number=Sing	_	_	_	_
32	tissue	tissue	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
33	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3617
# text = We hypothesize that activation of this protein, designated hStat5, helps govern the biological effects of IL-2 during the immune response.
1	We	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
2	hypothesize	hypothesize	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
3	that	that	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
4	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
5	of	of	ADP	IN	_	_	_	_	_
6	this	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
7	protein	protein	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
8	,	,	PUNCT	,	_	_	_	_	_
9	designated	designate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
10	hStat5	hstat5	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
11	,	,	PUNCT	,	_	_	_	_	_
12	helps	help	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
13	govern	govern	ADJ	JJ	Degree=Pos	_	_	_	_
14	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
15	biological	biological	ADJ	JJ	Degree=Pos	_	_	_	_
16	effects	effect	NOUN	NNS	Number=Plur	_	_	_	_
17	of	of	ADP	IN	_	_	_	_	_
18	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
19	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
20	2	2	NUM	CD	NumType=Card	_	_	_	_
21	during	during	ADP	IN	_	_	_	_	_
22	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
23	immune	immune	ADJ	JJ	Degree=Pos	_	_	_	_
24	response	response	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
25	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 3618
# text = Document 003003514 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	003003514	003003514	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 3619
# text = Retinoic acid activates interferon regulatory factor-1 gene expression in myeloid cells.
1	Retinoic	Retinoic	ADJ	JJ	Degree=Pos	_	_	_	_
2	acid	acid	ADJ	JJ	Degree=Pos	_	_	_	_
3	activates	activate	NOUN	NNS	Number=Plur	_	_	_	_
4	interferon	interferon	ADP	IN	_	_	_	_	_
5	regulatory	regulatory	ADJ	JJ	Degree=Pos	_	_	_	_
6	factor	factor	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
7	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
8	1	1	NUM	CD	NumType=Card	_	_	_	_
9	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
10	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
11	in	in	ADP	IN	_	_	_	_	_
12	myeloid	myeloid	ADJ	JJ	Degree=Pos	_	_	_	_
13	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
14	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 3620
# text = All-trans-retinoic acid (ATRA) is the drug of choice in the treatment of acute promyelocytic leukemia (APL).
1	All	all	DET	DT	_	_	_	_	SpaceAfter=No
2	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
3	trans	tran	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
5	retinoic	retinoic	ADJ	JJ	Degree=Pos	_	_	_	_
6	acid	acid	NOUN	NN	Number=Sing	_	_	_	_
7	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
8	ATRA	ATRA	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
9	)	)	PUNCT	-RRB-	_	_	_	_	_
10	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
11	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
12	drug	drug	NOUN	NN	Number=Sing	_	_	_	_
13	of	of	ADP	IN	_	_	_	_	_
14	choice	choice	NOUN	NN	Number=Sing	_	_	_	_
15	in	in	ADP	IN	_	_	_	_	_
16	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
17	treatment	treatment	NOUN	NN	Number=Sing	_	_	_	_
18	of	of	ADP	IN	_	_	_	_	_
19	acute	acute	ADJ	JJ	Degree=Pos	_	_	_	_
20	promyelocytic	promyelocytic	ADJ	JJ	Degree=Pos	_	_	_	_
21	leukemia	leukemia	NOUN	NN	Number=Sing	_	_	_	_
22	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
23	APL	APL	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
24	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
25	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3621
# text = ATRA induces both in vitro and in vivo differentiation of APL cells into mature granulocytes.
1	ATRA	Atra	PROPN	NNP	Number=Sing	_	_	_	_
2	induces	induce	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
3	both	both	CCONJ	CC	_	_	_	_	_
4	in	in	ADP	IN	_	_	_	_	_
5	vitro	vitro	NOUN	NN	Number=Sing	_	_	_	_
6	and	and	CCONJ	CC	_	_	_	_	_
7	in	in	ADP	IN	_	_	_	_	_
8	vivo	vivo	NOUN	NN	Number=Sing	_	_	_	_
9	differentiation	differentiation	NOUN	NN	Number=Sing	_	_	_	_
10	of	of	ADP	IN	_	_	_	_	_
11	APL	Apl	ADJ	JJ	Degree=Pos	_	_	_	_
12	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
13	into	into	ADP	IN	_	_	_	_	_
14	mature	mature	ADJ	JJ	Degree=Pos	_	_	_	_
15	granulocytes	granulocyte	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
16	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3622
# text = However, the molecular mechanisms involved in ATRA-dependent growth inhibition and cellular differentiation are not presently understood.
1	However	however	ADV	RB	_	_	_	_	SpaceAfter=No
2	,	,	PUNCT	,	_	_	_	_	_
3	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
4	molecular	molecular	ADJ	JJ	Degree=Pos	_	_	_	_
5	mechanisms	mechanism	NOUN	NNS	Number=Plur	_	_	_	_
6	involved	involve	ADJ	JJ	Degree=Pos	_	_	_	_
7	in	in	ADP	IN	_	_	_	_	_
8	ATRA	ATRA	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
9	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
10	dependent	dependent	ADJ	JJ	Degree=Pos	_	_	_	_
11	growth	growth	NOUN	NN	Number=Sing	_	_	_	_
12	inhibition	inhibition	NOUN	NN	Number=Sing	_	_	_	_
13	and	and	CCONJ	CC	_	_	_	_	_
14	cellular	cellular	ADJ	JJ	Degree=Pos	_	_	_	_
15	differentiation	differentiation	NOUN	NN	Number=Sing	_	_	_	_
16	are	be	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
17	not	not	PART	RB	_	_	_	_	_
18	presently	presently	ADV	RB	_	_	_	_	_
19	understood	understand	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
20	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3623
# text = The NB4 cell line, which is derived from the bone marrow of a patient with APL during relapse, can be used as a model system to study the growth and differentiation of APL cells.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	NB4	NB4	NUM	CD	NumType=Card	_	_	_	_
3	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
4	line	line	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
5	,	,	PUNCT	,	_	_	_	_	_
6	which	which	PRON	WDT	PronType=Rel	_	_	_	_
7	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
8	derived	derive	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
9	from	from	ADP	IN	_	_	_	_	_
10	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
11	bone	bone	NOUN	NN	Number=Sing	_	_	_	_
12	marrow	marrow	NOUN	NN	Number=Sing	_	_	_	_
13	of	of	ADP	IN	_	_	_	_	_
14	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
15	patient	patient	NOUN	NN	Number=Sing	_	_	_	_
16	with	with	ADP	IN	_	_	_	_	_
17	APL	Apl	NOUN	NNS	Number=Plur	_	_	_	_
18	during	during	ADP	IN	_	_	_	_	_
19	relapse	relapse	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
20	,	,	PUNCT	,	_	_	_	_	_
21	can	can	AUX	MD	VerbForm=Fin	_	_	_	_
22	be	be	AUX	VB	VerbForm=Inf	_	_	_	_
23	used	use	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
24	as	as	ADP	IN	_	_	_	_	_
25	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
26	model	model	NOUN	NN	Number=Sing	_	_	_	_
27	system	system	NOUN	NN	Number=Sing	_	_	_	_
28	to	to	PART	TO	_	_	_	_	_
29	study	study	VERB	VB	VerbForm=Inf	_	_	_	_
30	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
31	growth	growth	NOUN	NN	Number=Sing	_	_	_	_
32	and	and	CCONJ	CC	_	_	_	_	_
33	differentiation	differentiation	NOUN	NN	Number=Sing	_	_	_	_
34	of	of	ADP	IN	_	_	_	_	_
35	APL	Apl	ADJ	JJ	Degree=Pos	_	_	_	_
36	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
37	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3624
# text = Because interferon (IFN) regulatory factors (IRF-1 and IRF-2) and other IFN-inducible gene products regulate cell growth, we analyzed the effects of ATRA on the expression of these genes.
1	Because	because	SCONJ	IN	_	_	_	_	_
2	interferon	interferon	PROPN	NNP	Number=Sing	_	_	_	_
3	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
4	IFN	IFN	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
5	)	)	PUNCT	-RRB-	_	_	_	_	_
6	regulatory	regulatory	ADJ	JJ	Degree=Pos	_	_	_	_
7	factors	factor	NOUN	NNS	Number=Plur	_	_	_	_
8	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
9	IRF	IRF	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
10	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
11	1	1	NUM	CD	NumType=Card	_	_	_	_
12	and	and	CCONJ	CC	_	_	_	_	_
13	IRF	IRF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
14	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
15	2	2	X	LS	_	_	_	_	SpaceAfter=No
16	)	)	PUNCT	-RRB-	_	_	_	_	_
17	and	and	CCONJ	CC	_	_	_	_	_
18	other	other	ADJ	JJ	Degree=Pos	_	_	_	_
19	IFN	Ifn	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
20	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
21	inducible	inducible	ADJ	JJ	Degree=Pos	_	_	_	_
22	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
23	products	product	NOUN	NNS	Number=Plur	_	_	_	_
24	regulate	regulate	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
25	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
26	growth	growth	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
27	,	,	PUNCT	,	_	_	_	_	_
28	we	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
29	analyzed	analyze	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
30	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
31	effects	effect	NOUN	NNS	Number=Plur	_	_	_	_
32	of	of	ADP	IN	_	_	_	_	_
33	ATRA	ATRA	PROPN	NNP	Number=Sing	_	_	_	_
34	on	on	ADP	IN	_	_	_	_	_
35	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
36	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
37	of	of	ADP	IN	_	_	_	_	_
38	these	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
39	genes	gene	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
40	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3625
# text = We show that ATRA directly activates IRF-1 gene expression, followed by activation of IRF-2 and 2'-5' oligoadenylate synthetase (OAS) gene expression with slower kinetics.
1	We	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
2	show	show	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
3	that	that	SCONJ	IN	_	_	_	_	_
4	ATRA	ATRA	PROPN	NNP	Number=Sing	_	_	_	_
5	directly	directly	ADV	RB	_	_	_	_	_
6	activates	activate	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
7	IRF	IRF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
8	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
9	1	1	NUM	CD	NumType=Card	_	_	_	_
10	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
11	expression	expression	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
12	,	,	PUNCT	,	_	_	_	_	_
13	followed	follow	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
14	by	by	ADP	IN	_	_	_	_	_
15	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
16	of	of	ADP	IN	_	_	_	_	_
17	IRF	IRF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
18	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
19	2	2	NUM	CD	NumType=Card	_	_	_	_
20	and	and	CCONJ	CC	_	_	_	_	_
21	2	2	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
22	'	'	PUNCT	``	_	_	_	_	SpaceAfter=No
23	-	-	SYM	SYM	_	_	_	_	SpaceAfter=No
24	5	5	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
25	'	'	PUNCT	``	_	_	_	_	_
26	oligoadenylate	oligoadenylate	ADJ	JJ	Degree=Pos	_	_	_	_
27	synthetase	synthetase	NOUN	NN	Number=Sing	_	_	_	_
28	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
29	OAS	OAS	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
30	)	)	PUNCT	-RRB-	_	_	_	_	_
31	gene	gene	ADJ	JJ	Degree=Pos	_	_	_	_
32	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
33	with	with	ADP	IN	_	_	_	_	_
34	slower	slower	NOUN	NN	Number=Sing	_	_	_	_
35	kinetics	kinetic	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
36	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3626
# text = In addition to NB4 cells, ATRA also activated IRF-1 gene expression in HL-60, U937, and THP-1 cells, which all respond to ATRA by growth inhibition.
1	In	in	ADP	IN	_	_	_	_	_
2	addition	addition	NOUN	NN	Number=Sing	_	_	_	_
3	to	to	ADP	IN	_	_	_	_	_
4	NB4	NB4	NUM	CD	NumType=Card	_	_	_	_
5	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
6	,	,	PUNCT	,	_	_	_	_	_
7	ATRA	ATRA	PROPN	NNP	Number=Sing	_	_	_	_
8	also	also	ADV	RB	_	_	_	_	_
9	activated	activate	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
10	IRF	IRF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
11	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
12	1	1	NUM	CD	NumType=Card	_	_	_	_
13	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
14	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
15	in	in	ADP	IN	_	_	_	_	_
16	HL	HL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
17	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
18	60	60	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
19	,	,	PUNCT	,	_	_	_	_	_
20	U937	U937	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
21	,	,	PUNCT	,	_	_	_	_	_
22	and	and	CCONJ	CC	_	_	_	_	_
23	THP	Thp	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
24	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
25	1	1	NUM	CD	NumType=Card	_	_	_	_
26	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
27	,	,	PUNCT	,	_	_	_	_	_
28	which	which	PRON	WDT	PronType=Rel	_	_	_	_
29	all	all	DET	DT	_	_	_	_	_
30	respond	respond	NOUN	NN	Number=Sing	_	_	_	_
31	to	to	ADP	IN	_	_	_	_	_
32	ATRA	ATRA	PROPN	NNP	Number=Sing	_	_	_	_
33	by	by	ADP	IN	_	_	_	_	_
34	growth	growth	NOUN	NN	Number=Sing	_	_	_	_
35	inhibition	inhibition	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
36	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3627
# text = A more than additive increase in IRF-1 gene expression was seen with ATRA and IFN-gamma in NB4 cells.
1	A	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
2	more	more	ADJ	JJR	Degree=Cmp	_	_	_	_
3	than	than	ADP	IN	_	_	_	_	_
4	additive	additive	ADJ	JJ	Degree=Pos	_	_	_	_
5	increase	increase	NOUN	NN	Number=Sing	_	_	_	_
6	in	in	ADP	IN	_	_	_	_	_
7	IRF	IRF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
8	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
9	1	1	NUM	CD	NumType=Card	_	_	_	_
10	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
11	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
12	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
13	seen	see	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
14	with	with	ADP	IN	_	_	_	_	_
15	ATRA	ATRA	PROPN	NNP	Number=Sing	_	_	_	_
16	and	and	CCONJ	CC	_	_	_	_	_
17	IFN	IFN	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
18	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
19	gamma	gamma	NOUN	NN	Number=Sing	_	_	_	_
20	in	in	ADP	IN	_	_	_	_	_
21	NB4	NB4	NUM	CD	NumType=Card	_	_	_	_
22	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
23	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3628
# text = ATRA did not activate nuclear factor kappa B or signal transducer and activator of transcription (STAT) activation pathways, suggesting that an alternate mechanism is involved in IRF-1 gene activation.
1	ATRA	ATRA	ADV	RB	_	_	_	_	_
2	did	do	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
3	not	not	PART	RB	_	_	_	_	_
4	activate	activate	VERB	VB	VerbForm=Inf	_	_	_	_
5	nuclear	nuclear	ADJ	JJ	Degree=Pos	_	_	_	_
6	factor	factor	NOUN	NN	Number=Sing	_	_	_	_
7	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_
8	B	b	NOUN	NN	Number=Sing	_	_	_	_
9	or	or	CCONJ	CC	_	_	_	_	_
10	signal	signal	NOUN	NN	Number=Sing	_	_	_	_
11	transducer	transducer	NOUN	NN	Number=Sing	_	_	_	_
12	and	and	CCONJ	CC	_	_	_	_	_
13	activator	activator	NOUN	NN	Number=Sing	_	_	_	_
14	of	of	ADP	IN	_	_	_	_	_
15	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
16	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
17	STAT	STAT	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
18	)	)	PUNCT	-RRB-	_	_	_	_	_
19	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
20	pathways	pathway	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
21	,	,	PUNCT	,	_	_	_	_	_
22	suggesting	suggest	VERB	VBG	VerbForm=Ger	_	_	_	_
23	that	that	SCONJ	IN	_	_	_	_	_
24	an	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
25	alternate	alternate	ADJ	JJ	Degree=Pos	_	_	_	_
26	mechanism	mechanism	NOUN	NN	Number=Sing	_	_	_	_
27	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
28	involved	involved	ADJ	JJ	Degree=Pos	_	_	_	_
29	in	in	ADP	IN	_	_	_	_	_
30	IRF	IRF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
31	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
32	1	1	NUM	CD	NumType=Card	_	_	_	_
33	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
34	activation	activation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
35	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3629
# text = The ATRA-induced expression of IRF-1, an activator of transcription and repressor of transformation, may be one of the molecular mechanisms of ATRA-induced growth inhibition, and the basis for the synergistic actions of ATRA and IFNs in myeloid leukemia cells.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	ATRA	ATRa	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
3	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
4	induced	induce	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
5	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
6	of	of	ADP	IN	_	_	_	_	_
7	IRF	IRF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
8	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
9	1	1	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
10	,	,	PUNCT	,	_	_	_	_	_
11	an	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
12	activator	activator	NOUN	NN	Number=Sing	_	_	_	_
13	of	of	ADP	IN	_	_	_	_	_
14	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
15	and	and	CCONJ	CC	_	_	_	_	_
16	repressor	repressor	NOUN	NN	Number=Sing	_	_	_	_
17	of	of	ADP	IN	_	_	_	_	_
18	transformation	transformation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
19	,	,	PUNCT	,	_	_	_	_	_
20	may	may	AUX	MD	VerbForm=Fin	_	_	_	_
21	be	be	AUX	VB	VerbForm=Inf	_	_	_	_
22	one	one	NUM	CD	NumType=Card	_	_	_	_
23	of	of	ADP	IN	_	_	_	_	_
24	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
25	molecular	molecular	ADJ	JJ	Degree=Pos	_	_	_	_
26	mechanisms	mechanism	NOUN	NNS	Number=Plur	_	_	_	_
27	of	of	ADP	IN	_	_	_	_	_
28	ATRA	ATRA	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
29	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
30	induced	induce	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
31	growth	growth	NOUN	NN	Number=Sing	_	_	_	_
32	inhibition	inhibition	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
33	,	,	PUNCT	,	_	_	_	_	_
34	and	and	CCONJ	CC	_	_	_	_	_
35	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
36	basis	basis	NOUN	NN	Number=Sing	_	_	_	_
37	for	for	ADP	IN	_	_	_	_	_
38	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
39	synergistic	synergistic	ADJ	JJ	Degree=Pos	_	_	_	_
40	actions	action	NOUN	NNS	Number=Plur	_	_	_	_
41	of	of	ADP	IN	_	_	_	_	_
42	ATRA	ATRa	PROPN	NNP	Number=Sing	_	_	_	_
43	and	and	CCONJ	CC	_	_	_	_	_
44	IFNs	IFN	PROPN	NNP	Number=Sing	_	_	_	_
45	in	in	ADP	IN	_	_	_	_	_
46	myeloid	myeloid	ADJ	JJ	Degree=Pos	_	_	_	_
47	leukemia	leukemia	NOUN	NN	Number=Sing	_	_	_	_
48	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
49	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 3630
# text = Document 003003516 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	003003516	003003516	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 3631
# text = Differential nuclear localization of p50, p52, and RelB proteins in human accessory cells of the immune response in situ.
1	Differential	differential	ADJ	JJ	Degree=Pos	_	_	_	_
2	nuclear	nuclear	ADJ	JJ	Degree=Pos	_	_	_	_
3	localization	localization	NOUN	NN	Number=Sing	_	_	_	_
4	of	of	ADP	IN	_	_	_	_	_
5	p50	p50	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
6	,	,	PUNCT	,	_	_	_	_	_
7	p52	p52	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
8	,	,	PUNCT	,	_	_	_	_	_
9	and	and	CCONJ	CC	_	_	_	_	_
10	RelB	Relb	VERB	VB	Mood=Imp|VerbForm=Fin	_	_	_	_
11	proteins	protein	NOUN	NNS	Number=Plur	_	_	_	_
12	in	in	ADP	IN	_	_	_	_	_
13	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
14	accessory	accessory	ADJ	JJ	Degree=Pos	_	_	_	_
15	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
16	of	of	ADP	IN	_	_	_	_	_
17	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
18	immune	immune	ADJ	JJ	Degree=Pos	_	_	_	_
19	response	response	NOUN	NN	Number=Sing	_	_	_	_
20	in	in	ADP	IN	_	_	_	_	_
21	situ	situ	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
22	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 3632
# text = The Rel/NF-kappa B proteins, p50, p52, p65, c-Rel, and RelB, constitute a family of transcription factors involved in the positive regulation of a variety of genes during the immune response.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	Rel/	rel/	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
3	NF	Nf	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
4	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
5	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_
6	B	b	NOUN	NN	Number=Sing	_	_	_	_
7	proteins	protein	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
8	,	,	PUNCT	,	_	_	_	_	_
9	p50	p50	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
10	,	,	PUNCT	,	_	_	_	_	_
11	p52	p52	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
12	,	,	PUNCT	,	_	_	_	_	_
13	p65	p65	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
14	,	,	PUNCT	,	_	_	_	_	_
15	c	c	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
16	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
17	Rel	Rel	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
18	,	,	PUNCT	,	_	_	_	_	_
19	and	and	CCONJ	CC	_	_	_	_	_
20	RelB	RelB	VERB	VB	Mood=Imp|VerbForm=Fin	_	_	_	SpaceAfter=No
21	,	,	PUNCT	,	_	_	_	_	_
22	constitute	constitute	VERB	VB	Mood=Imp|VerbForm=Fin	_	_	_	_
23	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
24	family	family	NOUN	NN	Number=Sing	_	_	_	_
25	of	of	ADP	IN	_	_	_	_	_
26	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
27	factors	factor	NOUN	NNS	Number=Plur	_	_	_	_
28	involved	involved	ADJ	JJ	Degree=Pos	_	_	_	_
29	in	in	ADP	IN	_	_	_	_	_
30	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
31	positive	positive	ADJ	JJ	Degree=Pos	_	_	_	_
32	regulation	regulation	NOUN	NN	Number=Sing	_	_	_	_
33	of	of	ADP	IN	_	_	_	_	_
34	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
35	variety	variety	NOUN	NN	Number=Sing	_	_	_	_
36	of	of	ADP	IN	_	_	_	_	_
37	genes	gene	NOUN	NNS	Number=Plur	_	_	_	_
38	during	during	ADP	IN	_	_	_	_	_
39	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
40	immune	immune	ADJ	JJ	Degree=Pos	_	_	_	_
41	response	response	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
42	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3633
# text = Recently, it has been shown that RelB knockout mice have no dendritic cells (DC).
1	Recently	recently	ADV	RB	_	_	_	_	SpaceAfter=No
2	,	,	PUNCT	,	_	_	_	_	_
3	it	it	PRON	PRP	Case=Nom|Gender=Neut|Number=Sing|Person=3|PronType=Prs	_	_	_	_
4	has	have	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
5	been	be	AUX	VBN	Tense=Past|VerbForm=Part	_	_	_	_
6	shown	show	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
7	that	that	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
8	RelB	Relb	NOUN	NN	Number=Sing	_	_	_	_
9	knockout	knockout	ADP	IN	_	_	_	_	_
10	mice	mouse	NOUN	NNS	Number=Plur	_	_	_	_
11	have	have	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
12	no	no	DET	DT	_	_	_	_	_
13	dendritic	dendritic	ADJ	JJ	Degree=Pos	_	_	_	_
14	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
15	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
16	DC	DC	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
17	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
18	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3634
# text = An overexpression of p50 has been described in follicular dendritic cells (FDC).
1	An	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
2	overexpression	overexpression	NOUN	NN	Number=Sing	_	_	_	_
3	of	of	ADP	IN	_	_	_	_	_
4	p50	p50	NUM	CD	NumType=Card	_	_	_	_
5	has	have	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
6	been	be	AUX	VBN	Tense=Past|VerbForm=Part	_	_	_	_
7	described	describe	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
8	in	in	ADP	IN	_	_	_	_	_
9	follicular	follicular	ADJ	JJ	Degree=Pos	_	_	_	_
10	dendritic	dendritic	ADJ	JJ	Degree=Pos	_	_	_	_
11	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
12	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
13	FDC	FDC	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
14	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
15	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3635
# text = A constitutive NF-kappa B activity has been reported in mature macrophages.
1	A	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
2	constitutive	constitutive	ADJ	JJ	Degree=Pos	_	_	_	_
3	NF	Nf	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
4	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
5	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_
6	B	b	NOUN	NN	Number=Sing	_	_	_	_
7	activity	activity	NOUN	NN	Number=Sing	_	_	_	_
8	has	have	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
9	been	be	AUX	VBN	Tense=Past|VerbForm=Part	_	_	_	_
10	reported	report	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
11	in	in	ADP	IN	_	_	_	_	_
12	mature	mature	ADJ	JJ	Degree=Pos	_	_	_	_
13	macrophages	macrophage	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
14	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3636
# text = This led to the hypothesis that some of the Rel/NF-kappa B proteins were key nuclear factors in functions of accessory cells of the immune response.
1	This	this	PRON	DT	Number=Sing|PronType=Dem	_	_	_	_
2	led	lead	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
3	to	to	ADP	IN	_	_	_	_	_
4	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
5	hypothesis	hypothesis	NOUN	NN	Number=Sing	_	_	_	_
6	that	that	SCONJ	IN	_	_	_	_	_
7	some	some	DET	DT	_	_	_	_	_
8	of	of	ADP	IN	_	_	_	_	_
9	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
10	Rel	Rel	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
11	/	/	PUNCT	,	_	_	_	_	SpaceAfter=No
12	NF	NF	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
13	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
14	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_
15	B	b	NOUN	NN	Number=Sing	_	_	_	_
16	proteins	protein	NOUN	NNS	Number=Plur	_	_	_	_
17	were	be	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
18	key	key	ADJ	JJ	Degree=Pos	_	_	_	_
19	nuclear	nuclear	ADJ	JJ	Degree=Pos	_	_	_	_
20	factors	factor	NOUN	NNS	Number=Plur	_	_	_	_
21	in	in	ADP	IN	_	_	_	_	_
22	functions	function	NOUN	NNS	Number=Plur	_	_	_	_
23	of	of	ADP	IN	_	_	_	_	_
24	accessory	accessory	ADJ	JJ	Degree=Pos	_	_	_	_
25	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
26	of	of	ADP	IN	_	_	_	_	_
27	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
28	immune	immune	ADJ	JJ	Degree=Pos	_	_	_	_
29	response	response	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
30	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3637
# text = Therefore, we investigated in situ the nuclear localization of Rel/NF-kappa B proteins in accessory cells of the immune system by immunohistochemistry and double labeling by immunofluorescence from five normal human tonsils and five lymph nodes with follicular hyperplasia.
1	Therefore	therefore	ADV	RB	_	_	_	_	SpaceAfter=No
2	,	,	PUNCT	,	_	_	_	_	_
3	we	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
4	investigated	investigate	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
5	in	in	ADP	IN	_	_	_	_	_
6	situ	situ	PRON	PRP	Case=Acc|Person=2|PronType=Prs	_	_	_	_
7	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
8	nuclear	nuclear	ADJ	JJ	Degree=Pos	_	_	_	_
9	localization	localization	NOUN	NN	Number=Sing	_	_	_	_
10	of	of	ADP	IN	_	_	_	_	_
11	Rel	Rel	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
12	/	/	PUNCT	,	_	_	_	_	SpaceAfter=No
13	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
14	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
15	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_
16	B	b	NOUN	NN	Number=Sing	_	_	_	_
17	proteins	protein	NOUN	NNS	Number=Plur	_	_	_	_
18	in	in	ADP	IN	_	_	_	_	_
19	accessory	accessory	ADJ	JJ	Degree=Pos	_	_	_	_
20	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
21	of	of	ADP	IN	_	_	_	_	_
22	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
23	immune	immune	ADJ	JJ	Degree=Pos	_	_	_	_
24	system	system	NOUN	NN	Number=Sing	_	_	_	_
25	by	by	ADP	IN	_	_	_	_	_
26	immunohistochemistry	immunohistochemistry	ADJ	JJ	Degree=Pos	_	_	_	_
27	and	and	CCONJ	CC	_	_	_	_	_
28	double	double	ADJ	JJ	Degree=Pos	_	_	_	_
29	labeling	labele	NOUN	NN	Number=Sing	_	_	_	_
30	by	by	ADP	IN	_	_	_	_	_
31	immunofluorescence	immunofluorescence	NOUN	NN	Number=Sing	_	_	_	_
32	from	from	ADP	IN	_	_	_	_	_
33	five	five	NUM	CD	NumType=Card	_	_	_	_
34	normal	normal	ADJ	JJ	Degree=Pos	_	_	_	_
35	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
36	tonsils	tonsil	NOUN	NNS	Number=Plur	_	_	_	_
37	and	and	CCONJ	CC	_	_	_	_	_
38	five	five	NUM	CD	NumType=Card	_	_	_	_
39	lymph	lymph	NOUN	NN	Number=Sing	_	_	_	_
40	nodes	node	NOUN	NNS	Number=Plur	_	_	_	_
41	with	with	ADP	IN	_	_	_	_	_
42	follicular	follicular	ADJ	JJ	Degree=Pos	_	_	_	_
43	hyperplasia	hyperplasia	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
44	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3638
# text = Nuclear p65 and c-Rel proteins were found in all cell types including lymphocytes.
1	Nuclear	nuclear	ADJ	JJ	Degree=Pos	_	_	_	_
2	p65	p65	NOUN	NN	Number=Sing	_	_	_	_
3	and	and	CCONJ	CC	_	_	_	_	_
4	c	c	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
5	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
6	Rel	Rel	NOUN	NN	Number=Sing	_	_	_	_
7	proteins	protein	NOUN	NNS	Number=Plur	_	_	_	_
8	were	be	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
9	found	find	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
10	in	in	ADP	IN	_	_	_	_	_
11	all	all	DET	DT	_	_	_	_	_
12	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
13	types	type	NOUN	NNS	Number=Plur	_	_	_	_
14	including	include	VERB	VBG	VerbForm=Ger	_	_	_	_
15	lymphocytes	lymphocyte	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
16	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3639
# text = In germinal centers GC, p50, p52, and RelB were found in the nuclei of FDC only and were not detected in the nuclei of CD68+ cells.
1	In	in	ADP	IN	_	_	_	_	_
2	germinal	germinal	ADJ	JJ	Degree=Pos	_	_	_	_
3	centers	center	NOUN	NNS	Number=Plur	_	_	_	_
4	GC	GC	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
5	,	,	PUNCT	,	_	_	_	_	_
6	p50	p50	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
7	,	,	PUNCT	,	_	_	_	_	_
8	p52	p52	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
9	,	,	PUNCT	,	_	_	_	_	_
10	and	and	CCONJ	CC	_	_	_	_	_
11	RelB	RelB	PROPN	NNP	Number=Sing	_	_	_	_
12	were	be	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
13	found	find	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
14	in	in	ADP	IN	_	_	_	_	_
15	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
16	nuclei	nuclei	NOUN	NN	Number=Sing	_	_	_	_
17	of	of	ADP	IN	_	_	_	_	_
18	FDC	FDC	PROPN	NNP	Number=Sing	_	_	_	_
19	only	only	ADV	RB	_	_	_	_	_
20	and	and	CCONJ	CC	_	_	_	_	_
21	were	be	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
22	not	not	PART	RB	_	_	_	_	_
23	detected	detect	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
24	in	in	ADP	IN	_	_	_	_	_
25	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
26	nuclei	nuclei	NOUN	NN	Number=Sing	_	_	_	_
27	of	of	ADP	IN	_	_	_	_	_
28	CD68	CD68	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
29	+	+	SYM	SYM	_	_	_	_	_
30	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
31	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3640
# text = In T cell areas, p50, p52, and RelB were found in the nuclei of HLA-DR+ cells with an antigen-presenting cell (APC) morphology.
1	In	in	ADP	IN	_	_	_	_	_
2	T	t	PROPN	NNP	Number=Sing	_	_	_	_
3	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
4	areas	area	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
5	,	,	PUNCT	,	_	_	_	_	_
6	p50	p50	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
7	,	,	PUNCT	,	_	_	_	_	_
8	p52	p52	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
9	,	,	PUNCT	,	_	_	_	_	_
10	and	and	CCONJ	CC	_	_	_	_	_
11	RelB	RelB	PROPN	NNP	Number=Sing	_	_	_	_
12	were	be	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
13	found	find	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
14	in	in	ADP	IN	_	_	_	_	_
15	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
16	nuclei	nuclei	NOUN	NN	Number=Sing	_	_	_	_
17	of	of	ADP	IN	_	_	_	_	_
18	HLA	HLA	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
19	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
20	DR	dr	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
21	+	+	SYM	SYM	_	_	_	_	_
22	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
23	with	with	ADP	IN	_	_	_	_	_
24	an	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
25	antigen	antigen	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
26	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
27	presenting	present	VERB	VBG	VerbForm=Ger	_	_	_	_
28	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
29	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
30	APC	APC	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
31	)	)	PUNCT	-RRB-	_	_	_	_	_
32	morphology	morphology	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
33	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3641
# text = p52 and RelB were detected in the nuclei in both CD1a+ and CD68+ cells from the T cell area, whereas p50 was found only in CD68- and CD1a- cells.
1	p52	p52	NOUN	NN	Number=Sing	_	_	_	_
2	and	and	CCONJ	CC	_	_	_	_	_
3	RelB	Relb	NOUN	NN	Number=Sing	_	_	_	_
4	were	be	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
5	detected	detect	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
6	in	in	ADP	IN	_	_	_	_	_
7	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
8	nuclei	nuclei	NOUN	NN	Number=Sing	_	_	_	_
9	in	in	ADP	IN	_	_	_	_	_
10	both	both	DET	DT	_	_	_	_	_
11	CD1a	CD1a	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
12	+	+	SYM	SYM	_	_	_	_	_
13	and	and	CCONJ	CC	_	_	_	_	_
14	CD68	CD68	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
15	+	+	SYM	SYM	_	_	_	_	_
16	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
17	from	from	ADP	IN	_	_	_	_	_
18	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
19	T	T	PROPN	NNP	Number=Sing	_	_	_	_
20	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
21	area	area	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
22	,	,	PUNCT	,	_	_	_	_	_
23	whereas	whereas	SCONJ	IN	_	_	_	_	_
24	p50	p50	NOUN	NN	Number=Sing	_	_	_	_
25	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
26	found	find	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
27	only	only	ADV	RB	_	_	_	_	_
28	in	in	ADP	IN	_	_	_	_	_
29	CD68	CD68	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
30	-	-	PUNCT	,	_	_	_	_	_
31	and	and	CCONJ	CC	_	_	_	_	_
32	CD1a	CD1a	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
33	-	-	PUNCT	,	_	_	_	_	_
34	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
35	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3642
# text = Cells with nuclear p50 were negative for the CD38, CD20 and CD2 markers.
1	Cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
2	with	with	ADP	IN	_	_	_	_	_
3	nuclear	nuclear	ADJ	JJ	Degree=Pos	_	_	_	_
4	p50	p50	NOUN	NN	Number=Sing	_	_	_	_
5	were	be	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
6	negative	negative	ADJ	JJ	Degree=Pos	_	_	_	_
7	for	for	ADP	IN	_	_	_	_	_
8	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
9	CD38	Cd38	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
10	,	,	PUNCT	,	_	_	_	_	_
11	CD20	CD20	NUM	CD	NumType=Card	_	_	_	_
12	and	and	CCONJ	CC	_	_	_	_	_
13	CD2	CD2	NUM	CD	NumType=Card	_	_	_	_
14	markers	marker	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
15	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3643
# text = These results show that, physiologically, high levels of nuclear of p50, p52 and RelB are restricted to accessory cells of the immune system, which include FDC in GC, and DC and macrophages in the T cell zone, that specialized scavenger macrophages from GC do not have detectable levels of p52 and RelB, whereas macrophages from the T cell area, known to present the antigen to T cells, do have both nuclear p52 and RelB, and that in the T cell zone, p52 and RelB are located in nuclei of both CD1a+, CD68+ or both, cells APC, whereas p50 is restricted to CD1a- and CD68- APC.
1	These	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
2	results	result	NOUN	NNS	Number=Plur	_	_	_	_
3	show	show	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
4	that	that	SCONJ	IN	_	_	_	_	SpaceAfter=No
5	,	,	PUNCT	,	_	_	_	_	_
6	physiologically	physiologically	ADV	RB	_	_	_	_	SpaceAfter=No
7	,	,	PUNCT	,	_	_	_	_	_
8	high	high	ADJ	JJ	Degree=Pos	_	_	_	_
9	levels	level	NOUN	NNS	Number=Plur	_	_	_	_
10	of	of	ADP	IN	_	_	_	_	_
11	nuclear	nuclear	NOUN	NN	Number=Sing	_	_	_	_
12	of	of	ADP	IN	_	_	_	_	_
13	p50	p50	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
14	,	,	PUNCT	,	_	_	_	_	_
15	p52	p52	NOUN	NN	Number=Sing	_	_	_	_
16	and	and	CCONJ	CC	_	_	_	_	_
17	RelB	Relb	NOUN	NN	Number=Sing	_	_	_	_
18	are	be	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
19	restricted	restrict	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
20	to	to	PART	TO	_	_	_	_	_
21	accessory	accessory	VERB	VB	VerbForm=Inf	_	_	_	_
22	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
23	of	of	ADP	IN	_	_	_	_	_
24	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
25	immune	immune	ADJ	JJ	Degree=Pos	_	_	_	_
26	system	system	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
27	,	,	PUNCT	,	_	_	_	_	_
28	which	which	PRON	WDT	PronType=Rel	_	_	_	_
29	include	include	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
30	FDC	FDC	PROPN	NNP	Number=Sing	_	_	_	_
31	in	in	ADP	IN	_	_	_	_	_
32	GC	GC	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
33	,	,	PUNCT	,	_	_	_	_	_
34	and	and	CCONJ	CC	_	_	_	_	_
35	DC	DC	PROPN	NNP	Number=Sing	_	_	_	_
36	and	and	CCONJ	CC	_	_	_	_	_
37	macrophages	macrophage	NOUN	NNS	Number=Plur	_	_	_	_
38	in	in	ADP	IN	_	_	_	_	_
39	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
40	T	T	PROPN	NNP	Number=Sing	_	_	_	_
41	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
42	zone	zone	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
43	,	,	PUNCT	,	_	_	_	_	_
44	that	that	PRON	WDT	PronType=Rel	_	_	_	_
45	specialized	specialized	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
46	scavenger	scavenger	NOUN	NN	Number=Sing	_	_	_	_
47	macrophages	macrophage	NOUN	NNS	Number=Plur	_	_	_	_
48	from	from	ADP	IN	_	_	_	_	_
49	GC	GC	PROPN	NNPS	Number=Plur	_	_	_	_
50	do	do	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
51	not	not	PART	RB	_	_	_	_	_
52	have	have	VERB	VB	VerbForm=Inf	_	_	_	_
53	detectable	detectable	ADJ	JJ	Degree=Pos	_	_	_	_
54	levels	level	NOUN	NNS	Number=Plur	_	_	_	_
55	of	of	ADP	IN	_	_	_	_	_
56	p52	p52	NOUN	NN	Number=Sing	_	_	_	_
57	and	and	CCONJ	CC	_	_	_	_	_
58	RelB	Relb	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
59	,	,	PUNCT	,	_	_	_	_	_
60	whereas	whereas	SCONJ	IN	_	_	_	_	_
61	macrophages	macrophage	NOUN	NNS	Number=Plur	_	_	_	_
62	from	from	ADP	IN	_	_	_	_	_
63	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
64	T	T	PROPN	NNP	Number=Sing	_	_	_	_
65	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
66	area	area	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
67	,	,	PUNCT	,	_	_	_	_	_
68	known	known	ADJ	JJ	Degree=Pos	_	_	_	_
69	to	to	PART	TO	_	_	_	_	_
70	present	present	VERB	VB	VerbForm=Inf	_	_	_	_
71	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
72	antigen	antigen	NOUN	NNS	Number=Plur	_	_	_	_
73	to	to	PART	TO	_	_	_	_	_
74	T	t	VERB	VB	VerbForm=Inf	_	_	_	_
75	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
76	,	,	PUNCT	,	_	_	_	_	_
77	do	do	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
78	have	have	VERB	VB	VerbForm=Inf	_	_	_	_
79	both	both	DET	DT	_	_	_	_	_
80	nuclear	nuclear	ADJ	JJ	Degree=Pos	_	_	_	_
81	p52	p52	NOUN	NN	Number=Sing	_	_	_	_
82	and	and	CCONJ	CC	_	_	_	_	_
83	RelB	Relb	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
84	,	,	PUNCT	,	_	_	_	_	_
85	and	and	CCONJ	CC	_	_	_	_	_
86	that	that	PRON	DT	Number=Sing|PronType=Dem	_	_	_	_
87	in	in	ADP	IN	_	_	_	_	_
88	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
89	T	T	PROPN	NNP	Number=Sing	_	_	_	_
90	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
91	zone	zone	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
92	,	,	PUNCT	,	_	_	_	_	_
93	p52	p52	NOUN	NN	Number=Sing	_	_	_	_
94	and	and	CCONJ	CC	_	_	_	_	_
95	RelB	Relb	NOUN	NN	Number=Sing	_	_	_	_
96	are	be	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
97	located	locate	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
98	in	in	ADP	IN	_	_	_	_	_
99	nuclei	nuclei	NOUN	NN	Number=Sing	_	_	_	_
100	of	of	ADP	IN	_	_	_	_	_
101	both	both	DET	DT	_	_	_	_	_
102	CD1a	CD1a	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
103	+	+	SYM	SYM	_	_	_	_	SpaceAfter=No
104	,	,	PUNCT	,	_	_	_	_	_
105	CD68	CD68	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
106	+	+	SYM	SYM	_	_	_	_	_
107	or	or	CCONJ	CC	_	_	_	_	_
108	both	both	DET	DT	_	_	_	_	SpaceAfter=No
109	,	,	PUNCT	,	_	_	_	_	_
110	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
111	APC	Apc	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
112	,	,	PUNCT	,	_	_	_	_	_
113	whereas	whereas	SCONJ	IN	_	_	_	_	_
114	p50	p50	NOUN	NN	Number=Sing	_	_	_	_
115	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
116	restricted	restrict	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
117	to	to	ADP	IN	_	_	_	_	_
118	CD1a	CD1a	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
119	-	-	PUNCT	,	_	_	_	_	_
120	and	and	CCONJ	CC	_	_	_	_	_
121	CD68	CD68	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
122	-	-	PUNCT	HYPH	_	_	_	_	_
123	APC	APC	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
124	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3644
# text = The different patterns of p50, p52 and RelB protein nuclear localization may provide insight into their different roles during the immune response in vivo.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	different	different	ADJ	JJ	Degree=Pos	_	_	_	_
3	patterns	pattern	NOUN	NNS	Number=Plur	_	_	_	_
4	of	of	ADP	IN	_	_	_	_	_
5	p50	p50	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
6	,	,	PUNCT	,	_	_	_	_	_
7	p52	p52	NUM	CD	NumType=Card	_	_	_	_
8	and	and	CCONJ	CC	_	_	_	_	_
9	RelB	Relb	PROPN	NNP	Number=Sing	_	_	_	_
10	protein	protein	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
11	nuclear	nuclear	ADJ	JJ	Degree=Pos	_	_	_	_
12	localization	localization	NOUN	NN	Number=Sing	_	_	_	_
13	may	may	AUX	MD	VerbForm=Fin	_	_	_	_
14	provide	provide	VERB	VB	VerbForm=Inf	_	_	_	_
15	insight	insight	ADV	RB	_	_	_	_	_
16	into	into	ADP	IN	_	_	_	_	_
17	their	they	PRON	PRP$	Number=Plur|Person=3|Poss=Yes|PronType=Prs	_	_	_	_
18	different	different	ADJ	JJ	Degree=Pos	_	_	_	_
19	roles	role	NOUN	NNS	Number=Plur	_	_	_	_
20	during	during	ADP	IN	_	_	_	_	_
21	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
22	immune	immune	ADJ	JJ	Degree=Pos	_	_	_	_
23	response	response	NOUN	NN	Number=Sing	_	_	_	_
24	in	in	ADP	IN	_	_	_	_	_
25	vivo	vivo	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
26	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 3645
# text = Document 003003523 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	003003523	003003523	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 3646
# text = Glucocorticoid-mediated inhibition of interleukin-2 receptor alpha and -beta subunit expression by human T cells.
1	Glucocorticoid	Glucocorticoid	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
2	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
3	mediated	mediate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
4	inhibition	inhibition	NOUN	NN	Number=Sing	_	_	_	_
5	of	of	ADP	IN	_	_	_	_	_
6	interleukin	interleukin	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
7	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
8	2	2	NUM	CD	NumType=Card	_	_	_	_
9	receptor	receptor	NOUN	NN	Number=Sing	_	_	_	_
10	alpha	alpha	NOUN	NN	Number=Sing	_	_	_	_
11	and	and	CCONJ	CC	_	_	_	_	_
12	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
13	beta	beta	NOUN	NN	Number=Sing	_	_	_	_
14	subunit	subunit	NOUN	NN	Number=Sing	_	_	_	_
15	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
16	by	by	ADP	IN	_	_	_	_	_
17	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
18	T	t	PROPN	NNP	Number=Sing	_	_	_	_
19	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
20	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 3647
# text = To determine the mechanism of glucocorticoid (GC)-mediated inhibition of T cell functions, the effect of dexamethasone (DM) on T cell proliferation and interleukin-2 receptor (IL-2R) generation were studied.
1	To	to	PART	TO	_	_	_	_	_
2	determine	determine	VERB	VB	VerbForm=Inf	_	_	_	_
3	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
4	mechanism	mechanism	NOUN	NN	Number=Sing	_	_	_	_
5	of	of	ADP	IN	_	_	_	_	_
6	glucocorticoid	glucocorticoid	NOUN	NN	Number=Sing	_	_	_	_
7	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
8	GC	GC	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
9	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
10	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
11	mediated	mediate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
12	inhibition	inhibition	NOUN	NN	Number=Sing	_	_	_	_
13	of	of	ADP	IN	_	_	_	_	_
14	T	t	PROPN	NNP	Number=Sing	_	_	_	_
15	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
16	functions	function	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
17	,	,	PUNCT	,	_	_	_	_	_
18	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
19	effect	effect	NOUN	NN	Number=Sing	_	_	_	_
20	of	of	ADP	IN	_	_	_	_	_
21	dexamethasone	dexamethasone	NOUN	NN	Number=Sing	_	_	_	_
22	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
23	DM	DM	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
24	)	)	PUNCT	-RRB-	_	_	_	_	_
25	on	on	ADP	IN	_	_	_	_	_
26	T	T	PROPN	NNP	Number=Sing	_	_	_	_
27	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
28	proliferation	proliferation	NOUN	NN	Number=Sing	_	_	_	_
29	and	and	CCONJ	CC	_	_	_	_	_
30	interleukin	interleukin	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
31	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
32	2	2	NUM	CD	NumType=Card	_	_	_	_
33	receptor	receptor	NOUN	NN	Number=Sing	_	_	_	_
34	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
35	IL	Il	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
36	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
37	2	2	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
38	R	r	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
39	)	)	PUNCT	-RRB-	_	_	_	_	_
40	generation	generation	NOUN	NN	Number=Sing	_	_	_	_
41	were	be	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
42	studied	study	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	SpaceAfter=No
43	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3648
# text = Dexamethasone inhibited IL-2-induced T cell proliferation by 30%-88%, relative to its concentration within the cultures.
1	Dexamethasone	Dexamethasone	PROPN	NNP	Number=Sing	_	_	_	_
2	inhibited	inhibit	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
3	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
4	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
5	2	2	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
6	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
7	induced	induce	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
8	T	t	PROPN	NNP	Number=Sing	_	_	_	_
9	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
10	proliferation	proliferation	NOUN	NN	Number=Sing	_	_	_	_
11	by	by	ADP	IN	_	_	_	_	_
12	30%	30%	SYM	NN	Number=Sing	_	_	_	SpaceAfter=No
13	-	-	SYM	SYM	_	_	_	_	SpaceAfter=No
14	88	88	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
15	%	%	SYM	NN	Number=Sing	_	_	_	SpaceAfter=No
16	,	,	PUNCT	,	_	_	_	_	_
17	relative	relative	ADV	RB	_	_	_	_	_
18	to	to	ADP	IN	_	_	_	_	_
19	its	its	PRON	PRP$	Gender=Neut|Number=Sing|Person=3|Poss=Yes|PronType=Prs	_	_	_	_
20	concentration	concentration	NOUN	NN	Number=Sing	_	_	_	_
21	within	within	ADP	IN	_	_	_	_	_
22	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
23	cultures	culture	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
24	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3649
# text = The effect of DM on expression of IL-2R alpha (Tac, p55, CD25) and beta (p75) genes in activated T cells was examined next.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	effect	effect	NOUN	NN	Number=Sing	_	_	_	_
3	of	of	ADP	IN	_	_	_	_	_
4	DM	DM	NOUN	NN	Number=Sing	_	_	_	_
5	on	on	ADP	IN	_	_	_	_	_
6	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
7	of	of	ADP	IN	_	_	_	_	_
8	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
9	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
10	2R	2R	PROPN	NNP	Number=Sing	_	_	_	_
11	alpha	alpha	PROPN	NNP	Number=Sing	_	_	_	_
12	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
13	Tac	Tac	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
14	,	,	PUNCT	,	_	_	_	_	_
15	p55	p55	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
16	,	,	PUNCT	,	_	_	_	_	_
17	CD25	CD25	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
18	)	)	PUNCT	-RRB-	_	_	_	_	_
19	and	and	CCONJ	CC	_	_	_	_	_
20	beta	beta	NOUN	NN	Number=Sing	_	_	_	_
21	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
22	p75	p75	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
23	)	)	PUNCT	-RRB-	_	_	_	_	_
24	genes	gene	NOUN	NNS	Number=Plur	_	_	_	_
25	in	in	ADP	IN	_	_	_	_	_
26	activated	activate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
27	T	t	PROPN	NNP	Number=Sing	_	_	_	_
28	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
29	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
30	examined	examin	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
31	next	next	ADV	RB	_	_	_	_	SpaceAfter=No
32	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3650
# text = In T cells stimulated with purified phytohemagglutinin (PHA-p) and 4 beta-phorbol 12-myristate 13-acetate (PMA) addition of DM to the cultures resulted in a 60% reduction in IL-2R alpha and a 30% reduction in IL-2R beta membrane expression compared to T cells cultured in the absence of DM (p < 0.01).
1	In	in	ADP	IN	_	_	_	_	_
2	T	t	PROPN	NNP	Number=Sing	_	_	_	_
3	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
4	stimulated	stimulate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
5	with	with	ADP	IN	_	_	_	_	_
6	purified	purify	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
7	phytohemagglutinin	phytohemagglutinin	NOUN	NN	Number=Sing	_	_	_	_
8	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
9	PHA	PHa	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
10	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
11	p	p	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
12	)	)	PUNCT	-RRB-	_	_	_	_	_
13	and	and	CCONJ	CC	_	_	_	_	_
14	4	4	NUM	CD	NumType=Card	_	_	_	_
15	beta	beta	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
16	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
17	phorbol	phorbol	NOUN	NN	Number=Sing	_	_	_	_
18	12	12	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
19	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
20	myristate	myristate	NOUN	NN	Number=Sing	_	_	_	_
21	13	13	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
22	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
23	acetate	acetate	NOUN	NN	Number=Sing	_	_	_	_
24	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
25	PMA	PMA	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
26	)	)	PUNCT	-RRB-	_	_	_	_	_
27	addition	addition	NOUN	NN	Number=Sing	_	_	_	_
28	of	of	ADP	IN	_	_	_	_	_
29	DM	Dm	PROPN	NNP	Number=Sing	_	_	_	_
30	to	to	ADP	IN	_	_	_	_	_
31	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
32	cultures	culture	NOUN	NNS	Number=Plur	_	_	_	_
33	resulted	result	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
34	in	in	ADP	IN	_	_	_	_	_
35	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
36	60	60	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
37	%	%	SYM	NN	Number=Sing	_	_	_	_
38	reduction	reduction	NOUN	NN	Number=Sing	_	_	_	_
39	in	in	ADP	IN	_	_	_	_	_
40	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
41	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
42	2R	2R	PROPN	NNP	Number=Sing	_	_	_	_
43	alpha	alpha	PROPN	NNP	Number=Sing	_	_	_	_
44	and	and	CCONJ	CC	_	_	_	_	_
45	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
46	30	30	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
47	%	%	SYM	NN	Number=Sing	_	_	_	_
48	reduction	reduction	NOUN	NN	Number=Sing	_	_	_	_
49	in	in	ADP	IN	_	_	_	_	_
50	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
51	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
52	2R	2R	PROPN	NNP	Number=Sing	_	_	_	_
53	beta	beta	NOUN	NN	Number=Sing	_	_	_	_
54	membrane	membrane	NOUN	NN	Number=Sing	_	_	_	_
55	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
56	compared	compare	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
57	to	to	ADP	IN	_	_	_	_	_
58	T	t	PROPN	NNP	Number=Sing	_	_	_	_
59	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
60	cultured	culture	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
61	in	in	ADP	IN	_	_	_	_	_
62	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
63	absence	absence	NOUN	NN	Number=Sing	_	_	_	_
64	of	of	ADP	IN	_	_	_	_	_
65	DM	DM	PROPN	NNP	Number=Sing	_	_	_	_
66	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
67	p	p	NOUN	NN	Number=Sing	_	_	_	_
68	<	<	PUNCT	-LRB-	_	_	_	_	_
69	0.01	0.01	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
70	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
71	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3651
# text = Inhibition of membrane IL-2R alpha and IL-2R beta expression by 10(-6)
1	Inhibition	Inhibition	NOUN	NN	Number=Sing	_	_	_	_
2	of	of	ADP	IN	_	_	_	_	_
3	membrane	membrane	NOUN	NN	Number=Sing	_	_	_	_
4	IL	Il	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
5	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
6	2R	2r	PROPN	NNP	Number=Sing	_	_	_	_
7	alpha	alpha	PROPN	NNP	Number=Sing	_	_	_	_
8	and	and	CCONJ	CC	_	_	_	_	_
9	IL	Il	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
10	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
11	2R	2r	PROPN	NNP	Number=Sing	_	_	_	_
12	beta	beta	NOUN	NN	Number=Sing	_	_	_	_
13	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
14	by	by	ADP	IN	_	_	_	_	_
15	10	10	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
16	(-	(-	PUNCT	.	_	_	_	_	SpaceAfter=No
17	6	6	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
18	)	)	PUNCT	-RRB-	_	_	_	_	_

# sent_id = 3652
# text = M DM was partially reversible by recombinant human IL-2 (rhIL-2).
1	M	m	NOUN	NN	Number=Sing	_	_	_	_
2	DM	Dm	PROPN	NNP	Number=Sing	_	_	_	_
3	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
4	partially	partially	ADV	RB	_	_	_	_	_
5	reversible	reversible	ADJ	JJ	Degree=Pos	_	_	_	_
6	by	by	ADP	IN	_	_	_	_	_
7	recombinant	recombinant	ADJ	JJ	Degree=Pos	_	_	_	_
8	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
9	IL	Il	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
10	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
11	2	2	NUM	CD	NumType=Card	_	_	_	_
12	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
13	rhIL	rhil	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
14	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
15	2	2	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
16	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
17	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3653
# text = By Northern blot analysis, DM caused a comparable decrease in IL-2R alpha and in IL-2R beta mRNA levels to membrane receptor expression in mitogen-stimulated T cells.
1	By	by	ADP	IN	_	_	_	_	_
2	Northern	Northern	ADJ	JJ	Degree=Pos	_	_	_	_
3	blot	blot	NOUN	NN	Number=Sing	_	_	_	_
4	analysis	analysis	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
5	,	,	PUNCT	,	_	_	_	_	_
6	DM	DM	PROPN	NNP	Number=Sing	_	_	_	_
7	caused	cause	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
8	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
9	comparable	comparable	ADJ	JJ	Degree=Pos	_	_	_	_
10	decrease	decrease	NOUN	NN	Number=Sing	_	_	_	_
11	in	in	ADP	IN	_	_	_	_	_
12	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
13	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
14	2R	2R	PROPN	NNP	Number=Sing	_	_	_	_
15	alpha	alpha	PROPN	NNP	Number=Sing	_	_	_	_
16	and	and	CCONJ	CC	_	_	_	_	_
17	in	in	ADP	IN	_	_	_	_	_
18	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
19	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
20	2R	2R	PROPN	NNP	Number=Sing	_	_	_	_
21	beta	beta	PROPN	NNP	Number=Sing	_	_	_	_
22	mRNA	mRNA	PROPN	NNP	Number=Sing	_	_	_	_
23	levels	level	NOUN	NNS	Number=Plur	_	_	_	_
24	to	to	PART	TO	_	_	_	_	_
25	membrane	membrane	VERB	VB	VerbForm=Inf	_	_	_	_
26	receptor	receptor	NOUN	NN	Number=Sing	_	_	_	_
27	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
28	in	in	ADP	IN	_	_	_	_	_
29	mitogen	mitogen	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
30	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
31	stimulated	stimulate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
32	T	t	PROPN	NNP	Number=Sing	_	_	_	_
33	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
34	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3654
# text = By in vitro transcription assays, DM regulated IL-2R alpha gene expression at a transcriptional level while transcription of IL-2R beta gene was unaffected by DM.
1	By	by	ADP	IN	_	_	_	_	_
2	in	in	ADP	IN	_	_	_	_	_
3	vitro	vitro	NUM	CD	NumType=Card	_	_	_	_
4	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
5	assays	assay	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
6	,	,	PUNCT	,	_	_	_	_	_
7	DM	Dm	PROPN	NNP	Number=Sing	_	_	_	_
8	regulated	regulate	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
9	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
10	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
11	2	2	X	LS	_	_	_	_	SpaceAfter=No
12	R	r	X	GW	_	_	_	_	_
13	alpha	alpha	X	GW	_	_	_	_	_
14	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
15	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
16	at	at	ADP	IN	_	_	_	_	_
17	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
18	transcriptional	transcriptional	ADJ	JJ	Degree=Pos	_	_	_	_
19	level	level	NOUN	NN	Number=Sing	_	_	_	_
20	while	while	SCONJ	IN	_	_	_	_	_
21	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
22	of	of	ADP	IN	_	_	_	_	_
23	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
24	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
25	2R	2R	PROPN	NNP	Number=Sing	_	_	_	_
26	beta	beta	NOUN	NN	Number=Sing	_	_	_	_
27	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
28	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
29	unaffected	unaffected	ADJ	JJ	Degree=Pos	_	_	_	_
30	by	by	ADP	IN	_	_	_	_	_
31	DM	DM	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
32	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3655
# text = The mechanism of action of DM on IL-2R alpha transcription was examined by determining the mRNA levels of the p50 subunit of nuclear factor kappa B (NF-kappa B), a transcription factor that stimulates IL-2R alpha gene expression.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	mechanism	mechanism	NOUN	NN	Number=Sing	_	_	_	_
3	of	of	ADP	IN	_	_	_	_	_
4	action	action	NOUN	NN	Number=Sing	_	_	_	_
5	of	of	ADP	IN	_	_	_	_	_
6	DM	DM	PROPN	NNP	Number=Sing	_	_	_	_
7	on	on	ADP	IN	_	_	_	_	_
8	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
9	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
10	2R	2R	PROPN	NNP	Number=Sing	_	_	_	_
11	alpha	alpha	NOUN	NN	Number=Sing	_	_	_	_
12	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
13	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
14	examined	examin	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
15	by	by	SCONJ	IN	_	_	_	_	_
16	determining	determine	VERB	VBG	VerbForm=Ger	_	_	_	_
17	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
18	mRNA	mRNA	NOUN	NN	Number=Sing	_	_	_	_
19	levels	level	NOUN	NNS	Number=Plur	_	_	_	_
20	of	of	ADP	IN	_	_	_	_	_
21	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
22	p50	p50	NOUN	NN	Number=Sing	_	_	_	_
23	subunit	subunit	NOUN	NN	Number=Sing	_	_	_	_
24	of	of	ADP	IN	_	_	_	_	_
25	nuclear	nuclear	ADJ	JJ	Degree=Pos	_	_	_	_
26	factor	factor	NOUN	NN	Number=Sing	_	_	_	_
27	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_
28	B	b	PROPN	NNP	Number=Sing	_	_	_	_
29	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
30	NF	Nf	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
31	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
32	kappa	kappa	PROPN	NNP	Number=Sing	_	_	_	_
33	B	b	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
34	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
35	,	,	PUNCT	,	_	_	_	_	_
36	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
37	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
38	factor	factor	NOUN	NN	Number=Sing	_	_	_	_
39	that	that	PRON	WDT	PronType=Rel	_	_	_	_
40	stimulates	stimulate	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
41	IL	Il	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
42	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
43	2	2	X	LS	_	_	_	_	SpaceAfter=No
44	R	r	X	GW	_	_	_	_	_
45	alpha	alpha	X	FW	Foreign=Yes	_	_	_	_
46	gene	gene	ADJ	JJ	Degree=Pos	_	_	_	_
47	expression	expression	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
48	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3656
# text = The data indicate that 10(-6) M DM increased T cell p50 NF-kappa B mRNA levels by four-fold compared to the levels obtained in the absence of DM.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	data	data	NOUN	NN	Number=Sing	_	_	_	_
3	indicate	indicate	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
4	that	that	SCONJ	IN	_	_	_	_	_
5	10	10	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
6	(-	(-	PUNCT	.	_	_	_	_	SpaceAfter=No
7	6	6	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
8	)	)	PUNCT	-RRB-	_	_	_	_	_
9	M	m	NOUN	NN	Number=Sing	_	_	_	_
10	DM	Dm	NOUN	NN	Number=Sing	_	_	_	_
11	increased	increase	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
12	T	t	PROPN	NNP	Number=Sing	_	_	_	_
13	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
14	p50	p50	NUM	CD	NumType=Card	_	_	_	_
15	NF	Nf	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
16	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
17	kappa	kappa	PROPN	NNP	Number=Sing	_	_	_	_
18	B	b	PROPN	NNP	Number=Sing	_	_	_	_
19	mRNA	mRNa	PROPN	NNP	Number=Sing	_	_	_	_
20	levels	level	NOUN	NNS	Number=Plur	_	_	_	_
21	by	by	ADP	IN	_	_	_	_	_
22	four	four	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
23	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
24	fold	fold	NOUN	NN	Number=Sing	_	_	_	_
25	compared	compare	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
26	to	to	ADP	IN	_	_	_	_	_
27	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
28	levels	level	NOUN	NNS	Number=Plur	_	_	_	_
29	obtained	obtaine	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
30	in	in	ADP	IN	_	_	_	_	_
31	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
32	absence	absence	NOUN	NN	Number=Sing	_	_	_	_
33	of	of	ADP	IN	_	_	_	_	_
34	DM	DM	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
35	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3657
# text = Further, the level of nuclear proteins capable of binding to the NF-kappa B sites in activated T cells increased in response to DM.
1	Further	further	ADV	RB	_	_	_	_	SpaceAfter=No
2	,	,	PUNCT	,	_	_	_	_	_
3	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
4	level	level	NOUN	NN	Number=Sing	_	_	_	_
5	of	of	ADP	IN	_	_	_	_	_
6	nuclear	nuclear	ADJ	JJ	Degree=Pos	_	_	_	_
7	proteins	protein	NOUN	NNS	Number=Plur	_	_	_	_
8	capable	capable	ADJ	JJ	Degree=Pos	_	_	_	_
9	of	of	SCONJ	IN	_	_	_	_	_
10	binding	bind	VERB	VBG	VerbForm=Ger	_	_	_	_
11	to	to	ADP	IN	_	_	_	_	_
12	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
13	NF	Nf	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
14	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
15	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_
16	B	b	NOUN	NN	Number=Sing	_	_	_	_
17	sites	site	NOUN	NNS	Number=Plur	_	_	_	_
18	in	in	ADP	IN	_	_	_	_	_
19	activated	activated	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
20	T	t	PROPN	NNP	Number=Sing	_	_	_	_
21	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
22	increased	increase	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
23	in	in	ADP	IN	_	_	_	_	_
24	response	response	NOUN	NN	Number=Sing	_	_	_	_
25	to	to	ADP	IN	_	_	_	_	_
26	DM	DM	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
27	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3658
# text = In sum, DM regulates T cell membrane expression of IL-2R by more than one molecular mechanism.
1	In	in	ADP	IN	_	_	_	_	_
2	sum	sum	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
3	,	,	PUNCT	,	_	_	_	_	_
4	DM	DM	PROPN	NNP	Number=Sing	_	_	_	_
5	regulates	regulate	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
6	T	t	NUM	CD	NumType=Card	_	_	_	_
7	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
8	membrane	membrane	NOUN	NN	Number=Sing	_	_	_	_
9	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
10	of	of	ADP	IN	_	_	_	_	_
11	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
12	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
13	2R	2R	PROPN	NNP	Number=Sing	_	_	_	_
14	by	by	ADP	IN	_	_	_	_	_
15	more	more	ADJ	JJR	Degree=Cmp	_	_	_	_
16	than	than	ADP	IN	_	_	_	_	_
17	one	one	NUM	CD	NumType=Card	_	_	_	_
18	molecular	molecular	ADJ	JJ	Degree=Pos	_	_	_	_
19	mechanism	mechanism	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
20	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 3659
# text = Document 003003528 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	003003528	003003528	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 3660
# text = Glucocorticoid receptor in patients with lupus nephritis: relationship between receptor levels in mononuclear leukocytes and effect of glucocorticoid therapy.
1	Glucocorticoid	Glucocorticoid	ADJ	JJ	Degree=Pos	_	_	_	_
2	receptor	receptor	NOUN	NN	Number=Sing	_	_	_	_
3	in	in	ADP	IN	_	_	_	_	_
4	patients	patient	NOUN	NNS	Number=Plur	_	_	_	_
5	with	with	ADP	IN	_	_	_	_	_
6	lupus	lupus	NOUN	NN	Number=Sing	_	_	_	_
7	nephritis	nephritis	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
8	:	:	PUNCT	:	_	_	_	_	_
9	relationship	relationship	NOUN	NN	Number=Sing	_	_	_	_
10	between	between	ADP	IN	_	_	_	_	_
11	receptor	receptor	NOUN	NN	Number=Sing	_	_	_	_
12	levels	level	NOUN	NNS	Number=Plur	_	_	_	_
13	in	in	ADP	IN	_	_	_	_	_
14	mononuclear	mononuclear	ADJ	JJ	Degree=Pos	_	_	_	_
15	leukocytes	leukocyte	NOUN	NNS	Number=Plur	_	_	_	_
16	and	and	CCONJ	CC	_	_	_	_	_
17	effect	effect	NOUN	NN	Number=Sing	_	_	_	_
18	of	of	ADP	IN	_	_	_	_	_
19	glucocorticoid	glucocorticoid	ADJ	JJ	Degree=Pos	_	_	_	_
20	therapy	therapy	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
21	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 3661
# text = We investigated the clinical significance of glucocorticoid receptor determination in 20 patients with systemic lupus erythematosus (SLE) who afterwards developed nephrotic syndrome.
1	We	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
2	investigated	investigate	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
3	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
4	clinical	clinical	ADJ	JJ	Degree=Pos	_	_	_	_
5	significance	significance	NOUN	NN	Number=Sing	_	_	_	_
6	of	of	ADP	IN	_	_	_	_	_
7	glucocorticoid	glucocorticoid	ADJ	JJ	Degree=Pos	_	_	_	_
8	receptor	receptor	NOUN	NN	Number=Sing	_	_	_	_
9	determination	determination	NOUN	NN	Number=Sing	_	_	_	_
10	in	in	ADP	IN	_	_	_	_	_
11	20	20	NUM	CD	NumType=Card	_	_	_	_
12	patients	patient	NOUN	NNS	Number=Plur	_	_	_	_
13	with	with	ADP	IN	_	_	_	_	_
14	systemic	systemic	ADJ	JJ	Degree=Pos	_	_	_	_
15	lupus	lupus	NOUN	NN	Number=Sing	_	_	_	_
16	erythematosus	erythematosus	NOUN	NN	Number=Sing	_	_	_	_
17	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
18	SLE	SLE	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
19	)	)	PUNCT	-RRB-	_	_	_	_	_
20	who	who	PRON	WP	PronType=Rel	_	_	_	_
21	afterwards	afterwards	ADV	RB	_	_	_	_	_
22	developed	develop	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
23	nephrotic	nephrotic	ADJ	JJ	Degree=Pos	_	_	_	_
24	syndrome	syndrome	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
25	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3662
# text = Glucocorticoid receptor concentrations in mononuclear leukocytes (MNL) in these patients were comparable with those in both other patients with SLE and healthy persons.
1	Glucocorticoid	Glucocorticoid	ADJ	JJ	Degree=Pos	_	_	_	_
2	receptor	receptor	NOUN	NN	Number=Sing	_	_	_	_
3	concentrations	concentration	NOUN	NNS	Number=Plur	_	_	_	_
4	in	in	ADP	IN	_	_	_	_	_
5	mononuclear	mononuclear	ADJ	JJ	Degree=Pos	_	_	_	_
6	leukocytes	leukocyte	NOUN	NNS	Number=Plur	_	_	_	_
7	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
8	MNL	MNL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
9	)	)	PUNCT	-RRB-	_	_	_	_	_
10	in	in	ADP	IN	_	_	_	_	_
11	these	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
12	patients	patient	NOUN	NNS	Number=Plur	_	_	_	_
13	were	be	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
14	comparable	comparable	ADJ	JJ	Degree=Pos	_	_	_	_
15	with	with	ADP	IN	_	_	_	_	_
16	those	those	PRON	DT	Number=Plur|PronType=Dem	_	_	_	_
17	in	in	ADP	IN	_	_	_	_	_
18	both	both	DET	DT	_	_	_	_	_
19	other	other	ADJ	JJ	Degree=Pos	_	_	_	_
20	patients	patient	NOUN	NNS	Number=Plur	_	_	_	_
21	with	with	ADP	IN	_	_	_	_	_
22	SLE	Sle	NOUN	NN	Number=Sing	_	_	_	_
23	and	and	CCONJ	CC	_	_	_	_	_
24	healthy	healthy	ADJ	JJ	Degree=Pos	_	_	_	_
25	persons	person	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
26	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3663
# text = Improvement in urinary protein excretion and in disease activity, which was scored according to the SLE Disease Activity Index system of the University of Toronto, closely related to the glucocorticoid receptor concentrations in MNL isolated from the corresponding patients.
1	Improvement	improvement	NOUN	NN	Number=Sing	_	_	_	_
2	in	in	ADP	IN	_	_	_	_	_
3	urinary	urinary	ADJ	JJ	Degree=Pos	_	_	_	_
4	protein	protein	NOUN	NN	Number=Sing	_	_	_	_
5	excretion	excretion	NOUN	NN	Number=Sing	_	_	_	_
6	and	and	CCONJ	CC	_	_	_	_	_
7	in	in	ADP	IN	_	_	_	_	_
8	disease	disease	NOUN	NN	Number=Sing	_	_	_	_
9	activity	activity	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
10	,	,	PUNCT	,	_	_	_	_	_
11	which	which	PRON	WDT	PronType=Rel	_	_	_	_
12	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
13	scored	score	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
14	according	accord	VERB	VBG	VerbForm=Ger	_	_	_	_
15	to	to	ADP	IN	_	_	_	_	_
16	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
17	SLE	SLE	PROPN	NNP	Number=Sing	_	_	_	_
18	Disease	disease	NOUN	NN	Number=Sing	_	_	_	_
19	Activity	activity	NOUN	NN	Number=Sing	_	_	_	_
20	Index	index	NOUN	NN	Number=Sing	_	_	_	_
21	system	system	NOUN	NN	Number=Sing	_	_	_	_
22	of	of	ADP	IN	_	_	_	_	_
23	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
24	University	University	PROPN	NNP	Number=Sing	_	_	_	_
25	of	of	ADP	IN	_	_	_	_	_
26	Toronto	Toronto	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
27	,	,	PUNCT	,	_	_	_	_	_
28	closely	closely	ADV	RB	_	_	_	_	_
29	related	related	ADJ	JJ	Degree=Pos	_	_	_	_
30	to	to	ADP	IN	_	_	_	_	_
31	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
32	glucocorticoid	glucocorticoid	ADJ	JJ	Degree=Pos	_	_	_	_
33	receptor	receptor	NOUN	NN	Number=Sing	_	_	_	_
34	concentrations	concentration	NOUN	NNS	Number=Plur	_	_	_	_
35	in	in	ADP	IN	_	_	_	_	_
36	MNL	MNL	PROPN	NNP	Number=Sing	_	_	_	_
37	isolated	isolate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
38	from	from	ADP	IN	_	_	_	_	_
39	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
40	corresponding	corresponding	NOUN	NN	Number=Sing	_	_	_	_
41	patients	patient	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
42	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3664
# text = In summary, glucocorticoid receptor determination in patients with lupus nephritis may be a predictive clue for assessing responsiveness to glucocorticoid therapy.
1	In	in	ADP	IN	_	_	_	_	_
2	summary	summary	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
3	,	,	PUNCT	,	_	_	_	_	_
4	glucocorticoid	glucocorticoid	ADJ	JJ	Degree=Pos	_	_	_	_
5	receptor	receptor	NOUN	NN	Number=Sing	_	_	_	_
6	determination	determination	NOUN	NN	Number=Sing	_	_	_	_
7	in	in	ADP	IN	_	_	_	_	_
8	patients	patient	NOUN	NNS	Number=Plur	_	_	_	_
9	with	with	ADP	IN	_	_	_	_	_
10	lupus	lupus	NOUN	NN	Number=Sing	_	_	_	_
11	nephritis	nephritis	NOUN	NN	Number=Sing	_	_	_	_
12	may	may	AUX	MD	VerbForm=Fin	_	_	_	_
13	be	be	AUX	VB	VerbForm=Inf	_	_	_	_
14	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
15	predictive	predictive	ADJ	JJ	Degree=Pos	_	_	_	_
16	clue	clue	NOUN	NN	Number=Sing	_	_	_	_
17	for	for	SCONJ	IN	_	_	_	_	_
18	assessing	assess	VERB	VBG	VerbForm=Ger	_	_	_	_
19	responsiveness	responsiveness	NOUN	NN	Number=Sing	_	_	_	_
20	to	to	PART	TO	_	_	_	_	_
21	glucocorticoid	glucocorticoid	VERB	VB	VerbForm=Inf	_	_	_	_
22	therapy	therapy	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
23	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 3665
# text = Document 003003533 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	003003533	003003533	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 3666
# text = rel
1	rel	rel	NOUN	NN	Number=Sing	_	_	_	_

# sent_id = 3667
# text = Is rapidly tyrosine-phosphorylated following granulocyte-colony stimulating factor treatment of human neutrophils.
1	Is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
2	rapidly	rapidly	ADV	RB	_	_	_	_	_
3	tyrosine	tyrosine	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
4	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
5	phosphorylated	phosphorylate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
6	following	follow	VERB	VBG	VerbForm=Ger	_	_	_	_
7	granulocyte	granulocyte	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
8	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
9	colony	colony	NOUN	NN	Number=Sing	_	_	_	_
10	stimulating	stimulating	VERB	VBG	VerbForm=Ger	_	_	_	_
11	factor	factor	NOUN	NN	Number=Sing	_	_	_	_
12	treatment	treatment	NOUN	NN	Number=Sing	_	_	_	_
13	of	of	ADP	IN	_	_	_	_	_
14	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
15	neutrophils	neutrophil	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
16	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 3668
# text = Stimulation of neutrophils with granulocyte-colony stimulating factor (G-CSF) results in an enhanced respiratory burst, prolonged survival, and increased tumor cell killing.
1	Stimulation	Stimulation	NOUN	NN	Number=Sing	_	_	_	_
2	of	of	ADP	IN	_	_	_	_	_
3	neutrophils	neutrophil	NOUN	NNS	Number=Plur	_	_	_	_
4	with	with	ADP	IN	_	_	_	_	_
5	granulocyte	granulocyte	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
6	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
7	colony	colony	NOUN	NN	Number=Sing	_	_	_	_
8	stimulating	stimulating	NOUN	NN	Number=Sing	_	_	_	_
9	factor	factor	NOUN	NN	Number=Sing	_	_	_	_
10	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
11	G-	G-	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
12	CSF	Csf	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
13	)	)	PUNCT	-RRB-	_	_	_	_	_
14	results	result	NOUN	NNS	Number=Plur	_	_	_	_
15	in	in	ADP	IN	_	_	_	_	_
16	an	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
17	enhanced	enhance	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
18	respiratory	respiratory	NOUN	NN	Number=Sing	_	_	_	_
19	burst	burst	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
20	,	,	PUNCT	,	_	_	_	_	_
21	prolonged	prolonge	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
22	survival	survival	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
23	,	,	PUNCT	,	_	_	_	_	_
24	and	and	CCONJ	CC	_	_	_	_	_
25	increased	increase	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
26	tumor	tumor	NOUN	NN	Number=Sing	_	_	_	_
27	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
28	killing	killing	VERB	VBG	VerbForm=Ger	_	_	_	SpaceAfter=No
29	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3669
# text = The effects of G-CSF are mediated by binding to specific, high affinity receptors.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	effects	effect	NOUN	NNS	Number=Plur	_	_	_	_
3	of	of	ADP	IN	_	_	_	_	_
4	G-	g-	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
5	CSF	Csf	NOUN	NN	Number=Sing	_	_	_	_
6	are	be	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
7	mediated	mediate	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
8	by	by	SCONJ	IN	_	_	_	_	_
9	binding	bind	VERB	VBG	VerbForm=Ger	_	_	_	_
10	to	to	ADP	IN	_	_	_	_	_
11	specific	specific	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
12	,	,	PUNCT	,	_	_	_	_	_
13	high	high	ADJ	JJ	Degree=Pos	_	_	_	_
14	affinity	affinity	NOUN	NN	Number=Sing	_	_	_	_
15	receptors	receptor	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
16	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3670
# text = G-CSF receptors lack intrinsic tyrosine kinase activity, but activation of the receptor results in the rapid induction of tyrosine kinase activity.
1	G-	G-	SYM	NFP	_	_	_	_	SpaceAfter=No
2	CSF	CSF	PROPN	NNP	Number=Sing	_	_	_	_
3	receptors	receptor	NOUN	NNS	Number=Plur	_	_	_	_
4	lack	lack	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
5	intrinsic	intrinsic	ADJ	JJ	Degree=Pos	_	_	_	_
6	tyrosine	tyrosine	NOUN	NN	Number=Sing	_	_	_	_
7	kinase	kinase	NOUN	NN	Number=Sing	_	_	_	_
8	activity	activity	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
9	,	,	PUNCT	,	_	_	_	_	_
10	but	but	CCONJ	CC	_	_	_	_	_
11	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
12	of	of	ADP	IN	_	_	_	_	_
13	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
14	receptor	receptor	NOUN	NN	Number=Sing	_	_	_	_
15	results	result	NOUN	NNS	Number=Plur	_	_	_	_
16	in	in	ADP	IN	_	_	_	_	_
17	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
18	rapid	rapid	ADJ	JJ	Degree=Pos	_	_	_	_
19	induction	induction	NOUN	NN	Number=Sing	_	_	_	_
20	of	of	ADP	IN	_	_	_	_	_
21	tyrosine	tyrosine	NOUN	NN	Number=Sing	_	_	_	_
22	kinase	kinase	NOUN	NN	Number=Sing	_	_	_	_
23	activity	activity	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
24	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3671
# text = Antiphosphotyrosine immunoblots of whole cell lysates prepared from neutrophils show that the G-CSF rapidly induces prominent tyrosine phosphorylation of a protein of a relative molecular mass of 80 kDa.
1	Antiphosphotyrosine	Antiphosphotyrosine	ADJ	JJ	Degree=Pos	_	_	_	_
2	immunoblots	immunoblot	NOUN	NNS	Number=Plur	_	_	_	_
3	of	of	ADP	IN	_	_	_	_	_
4	whole	whole	ADJ	JJ	Degree=Pos	_	_	_	_
5	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
6	lysates	lysate	NOUN	NNS	Number=Plur	_	_	_	_
7	prepared	prepare	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
8	from	from	ADP	IN	_	_	_	_	_
9	neutrophils	neutrophil	NOUN	NNS	Number=Plur	_	_	_	_
10	show	show	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
11	that	that	SCONJ	IN	_	_	_	_	_
12	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
13	G-	g-	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
14	CSF	CSF	PROPN	NNP	Number=Sing	_	_	_	_
15	rapidly	rapidly	ADV	RB	_	_	_	_	_
16	induces	induce	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
17	prominent	prominent	ADJ	JJ	Degree=Pos	_	_	_	_
18	tyrosine	tyrosine	NOUN	NN	Number=Sing	_	_	_	_
19	phosphorylation	phosphorylation	NOUN	NN	Number=Sing	_	_	_	_
20	of	of	ADP	IN	_	_	_	_	_
21	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
22	protein	protein	NOUN	NN	Number=Sing	_	_	_	_
23	of	of	ADP	IN	_	_	_	_	_
24	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
25	relative	relative	ADV	RB	_	_	_	_	_
26	molecular	molecular	ADJ	JJ	Degree=Pos	_	_	_	_
27	mass	mass	NOUN	NN	Number=Sing	_	_	_	_
28	of	of	ADP	IN	_	_	_	_	_
29	80	80	NUM	CD	NumType=Card	_	_	_	_
30	kDa	kDa	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
31	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3672
# text = Using monospecific antibodies, the 80-kDa tyrosine-phosphorylated protein has been shown to be p80c-rel, a proto-oncogene belonging to a family of transcriptional regulators which include NF-kB.
1	Using	use	VERB	VBG	VerbForm=Ger	_	_	_	_
2	monospecific	monospecific	ADJ	JJ	Degree=Pos	_	_	_	_
3	antibodies	antibody	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	,	,	PUNCT	,	_	_	_	_	_
5	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
6	80	80	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
7	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
8	kDa	kDa	NOUN	NN	Number=Sing	_	_	_	_
9	tyrosine	tyrosine	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
10	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
11	phosphorylated	phosphorylate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
12	protein	protein	NOUN	NN	Number=Sing	_	_	_	_
13	has	have	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
14	been	be	AUX	VBN	Tense=Past|VerbForm=Part	_	_	_	_
15	shown	show	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
16	to	to	PART	TO	_	_	_	_	_
17	be	be	AUX	VB	VerbForm=Inf	_	_	_	_
18	p80c	p80c	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
19	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
20	rel	rel	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
21	,	,	PUNCT	,	_	_	_	_	_
22	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
23	proto	proto	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
24	-oncogene	-oncogene	NOUN	NN	Number=Sing	_	_	_	_
25	belonging	belong	VERB	VBG	VerbForm=Ger	_	_	_	_
26	to	to	ADP	IN	_	_	_	_	_
27	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
28	family	family	NOUN	NN	Number=Sing	_	_	_	_
29	of	of	ADP	IN	_	_	_	_	_
30	transcriptional	transcriptional	ADJ	JJ	Degree=Pos	_	_	_	_
31	regulators	regulator	NOUN	NNS	Number=Plur	_	_	_	_
32	which	which	PRON	WDT	PronType=Rel	_	_	_	_
33	include	include	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
34	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
35	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
36	kB	kb	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
37	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3673
# text = The induction of tyrosine phosphorylation of p80c-rel was unique to G-CSF in that granulocyte-macrophage colony stimulating factor which also stimulates neutrophils and induces tyrosine phosphorylation does not result in tyrosine phosphorylation of p80c-rel.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	induction	induction	NOUN	NN	Number=Sing	_	_	_	_
3	of	of	ADP	IN	_	_	_	_	_
4	tyrosine	tyrosine	NOUN	NN	Number=Sing	_	_	_	_
5	phosphorylation	phosphorylation	NOUN	NN	Number=Sing	_	_	_	_
6	of	of	ADP	IN	_	_	_	_	_
7	p80c	p80c	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
8	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
9	rel	rel	NOUN	NN	Number=Sing	_	_	_	_
10	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
11	unique	unique	ADJ	JJ	Degree=Pos	_	_	_	_
12	to	to	ADP	IN	_	_	_	_	_
13	G-	G-	PUNCT	:	_	_	_	_	SpaceAfter=No
14	CSF	CSF	PROPN	NNP	Number=Sing	_	_	_	_
15	in	in	ADP	IN	_	_	_	_	_
16	that	that	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
17	granulocyte	granulocyte	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
18	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
19	macrophage	macrophage	NOUN	NN	Number=Sing	_	_	_	_
20	colony	colony	NOUN	NN	Number=Sing	_	_	_	_
21	stimulating	stimulate	VERB	VBG	VerbForm=Ger	_	_	_	_
22	factor	factor	NOUN	NN	Number=Sing	_	_	_	_
23	which	which	PRON	WDT	PronType=Rel	_	_	_	_
24	also	also	ADV	RB	_	_	_	_	_
25	stimulates	stimulate	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
26	neutrophils	neutrophil	NOUN	NNS	Number=Plur	_	_	_	_
27	and	and	CCONJ	CC	_	_	_	_	_
28	induces	induce	NOUN	NNS	Number=Plur	_	_	_	_
29	tyrosine	tyrosine	NOUN	NN	Number=Sing	_	_	_	_
30	phosphorylation	phosphorylation	NOUN	NN	Number=Sing	_	_	_	_
31	does	do	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
32	not	not	PART	RB	_	_	_	_	_
33	result	result	VERB	VB	VerbForm=Inf	_	_	_	_
34	in	in	ADP	IN	_	_	_	_	_
35	tyrosine	tyrosine	NOUN	NN	Number=Sing	_	_	_	_
36	phosphorylation	phosphorylation	NOUN	NN	Number=Sing	_	_	_	_
37	of	of	ADP	IN	_	_	_	_	_
38	p80c	p80c	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
39	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
40	rel	rel	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
41	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3674
# text = The consequences of p80c-rel tyrosine phosphorylation are not yet known; however, tyrosine-phosphorylated p80c-rel is capable of binding to DNA, and G-CSF stimulation results in an increase in the amount of p80c-rel which binds to DNA.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	consequences	consequence	NOUN	NNS	Number=Plur	_	_	_	_
3	of	of	ADP	IN	_	_	_	_	_
4	p80c	p80c	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
5	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
6	rel	rel	NOUN	NN	Number=Sing	_	_	_	_
7	tyrosine	tyrosine	NOUN	NN	Number=Sing	_	_	_	_
8	phosphorylation	phosphorylation	NOUN	NN	Number=Sing	_	_	_	_
9	are	be	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
10	not	not	PART	RB	_	_	_	_	_
11	yet	yet	ADV	RB	_	_	_	_	_
12	known	known	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	SpaceAfter=No
13	;	;	PUNCT	,	_	_	_	_	_
14	however	however	ADV	RB	_	_	_	_	SpaceAfter=No
15	,	,	PUNCT	,	_	_	_	_	_
16	tyrosine	tyrosine	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
17	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
18	phosphorylated	phosphorylate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
19	p80c	p80c	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
20	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
21	rel	rel	NOUN	NN	Number=Sing	_	_	_	_
22	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
23	capable	capable	ADJ	JJ	Degree=Pos	_	_	_	_
24	of	of	SCONJ	IN	_	_	_	_	_
25	binding	bind	VERB	VBG	VerbForm=Ger	_	_	_	_
26	to	to	ADP	IN	_	_	_	_	_
27	DNA	Dna	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
28	,	,	PUNCT	,	_	_	_	_	_
29	and	and	CCONJ	CC	_	_	_	_	_
30	G-	G-	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
31	CSF	Csf	NOUN	NN	Number=Sing	_	_	_	_
32	stimulation	stimulation	NOUN	NN	Number=Sing	_	_	_	_
33	results	result	NOUN	NNS	Number=Plur	_	_	_	_
34	in	in	ADP	IN	_	_	_	_	_
35	an	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
36	increase	increase	NOUN	NN	Number=Sing	_	_	_	_
37	in	in	ADP	IN	_	_	_	_	_
38	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
39	amount	amount	NOUN	NN	Number=Sing	_	_	_	_
40	of	of	ADP	IN	_	_	_	_	_
41	p80c	p80c	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
42	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
43	rel	rel	NOUN	NN	Number=Sing	_	_	_	_
44	which	which	PRON	WDT	PronType=Rel	_	_	_	_
45	binds	bind	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
46	to	to	ADP	IN	_	_	_	_	_
47	DNA	Dna	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
48	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3675
# text = These results demonstrate that one of the first biochemical events which occurs in neutrophils following G-CSF stimulation, activation of a tyrosine kinase, leads directly to the tyrosine phosphorylation of p80c-rel.
1	These	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
2	results	result	NOUN	NNS	Number=Plur	_	_	_	_
3	demonstrate	demonstrate	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
4	that	that	SCONJ	IN	_	_	_	_	_
5	one	one	NUM	CD	NumType=Card	_	_	_	_
6	of	of	ADP	IN	_	_	_	_	_
7	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
8	first	first	ADJ	JJ	Degree=Pos|NumType=Ord	_	_	_	_
9	biochemical	biochemical	ADJ	JJ	Degree=Pos	_	_	_	_
10	events	event	NOUN	NNS	Number=Plur	_	_	_	_
11	which	which	PRON	WDT	PronType=Rel	_	_	_	_
12	occurs	occur	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
13	in	in	ADP	IN	_	_	_	_	_
14	neutrophils	neutrophil	NOUN	NNS	Number=Plur	_	_	_	_
15	following	follow	VERB	VBG	VerbForm=Ger	_	_	_	_
16	G-	G-	PUNCT	,	_	_	_	_	SpaceAfter=No
17	CSF	CSF	PROPN	NNP	Number=Sing	_	_	_	_
18	stimulation	stimulation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
19	,	,	PUNCT	,	_	_	_	_	_
20	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
21	of	of	ADP	IN	_	_	_	_	_
22	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
23	tyrosine	tyrosine	NOUN	NN	Number=Sing	_	_	_	_
24	kinase	kinase	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
25	,	,	PUNCT	,	_	_	_	_	_
26	leads	lead	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
27	directly	directly	ADV	RB	_	_	_	_	_
28	to	to	ADP	IN	_	_	_	_	_
29	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
30	tyrosine	tyrosine	NOUN	NN	Number=Sing	_	_	_	_
31	phosphorylation	phosphorylation	NOUN	NN	Number=Sing	_	_	_	_
32	of	of	ADP	IN	_	_	_	_	_
33	p80c	p80c	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
34	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
35	rel	rel	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
36	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3676
# text = Thus, the tyrosine kinase activated by G-CSF appears to directly transduce a signal to a protein which functions as a transcriptional regulator.
1	Thus	thus	ADV	RB	_	_	_	_	SpaceAfter=No
2	,	,	PUNCT	,	_	_	_	_	_
3	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
4	tyrosine	tyrosine	ADJ	JJ	Degree=Pos	_	_	_	_
5	kinase	kinase	NOUN	NN	Number=Sing	_	_	_	_
6	activated	activate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
7	by	by	ADP	IN	_	_	_	_	_
8	G	G	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
9	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
10	CSF	CSF	PROPN	NNP	Number=Sing	_	_	_	_
11	appears	appear	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
12	to	to	PART	TO	_	_	_	_	_
13	directly	directly	ADV	RB	_	_	_	_	_
14	transduce	transduce	VERB	VB	VerbForm=Inf	_	_	_	_
15	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
16	signal	signal	NOUN	NN	Number=Sing	_	_	_	_
17	to	to	ADP	IN	_	_	_	_	_
18	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
19	protein	protein	NOUN	NN	Number=Sing	_	_	_	_
20	which	which	PRON	WDT	PronType=Rel	_	_	_	_
21	functions	function	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
22	as	as	ADP	IN	_	_	_	_	_
23	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
24	transcriptional	transcriptional	ADJ	JJ	Degree=Pos	_	_	_	_
25	regulator	regulator	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
26	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 3677
# text = Document 003003538 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	003003538	003003538	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 3678
# text = Activation of STAT5 by IL-4 relies on Janus kinase function but not on receptor tyrosine phosphorylation, and can contribute to both cell proliferation and gene regulation.
1	Activation	Activation	NOUN	NN	Number=Sing	_	_	_	_
2	of	of	ADP	IN	_	_	_	_	_
3	STAT5	STAT5	PROPN	NNP	Number=Sing	_	_	_	_
4	by	by	ADP	IN	_	_	_	_	_
5	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
6	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
7	4	4	NUM	CD	NumType=Card	_	_	_	_
8	relies	rely	NOUN	NNS	Number=Plur	_	_	_	_
9	on	on	ADP	IN	_	_	_	_	_
10	Janus	Janus	PROPN	NNP	Number=Sing	_	_	_	_
11	kinase	kinase	NOUN	NN	Number=Sing	_	_	_	_
12	function	function	NOUN	NN	Number=Sing	_	_	_	_
13	but	but	CCONJ	CC	_	_	_	_	_
14	not	not	PART	RB	_	_	_	_	_
15	on	on	ADP	IN	_	_	_	_	_
16	receptor	receptor	NOUN	NN	Number=Sing	_	_	_	_
17	tyrosine	tyrosine	NOUN	NN	Number=Sing	_	_	_	_
18	phosphorylation	phosphorylation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
19	,	,	PUNCT	,	_	_	_	_	_
20	and	and	CCONJ	CC	_	_	_	_	_
21	can	can	AUX	MD	VerbForm=Fin	_	_	_	_
22	contribute	contribute	VERB	VB	VerbForm=Inf	_	_	_	_
23	to	to	ADP	IN	_	_	_	_	_
24	both	both	DET	DT	_	_	_	_	_
25	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
26	proliferation	proliferation	NOUN	NN	Number=Sing	_	_	_	_
27	and	and	CCONJ	CC	_	_	_	_	_
28	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
29	regulation	regulation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
30	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 3679
# text = We have investigated mechanisms and consequences of STAT5 activation through the human IL-4 receptor (IL-4R).
1	We	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
2	have	have	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
3	investigated	investigate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
4	mechanisms	mechanism	NOUN	NNS	Number=Plur	_	_	_	_
5	and	and	CCONJ	CC	_	_	_	_	_
6	consequences	consequences	NOUN	NNS	Number=Plur	_	_	_	_
7	of	of	ADP	IN	_	_	_	_	_
8	STAT5	stat5	NUM	CD	NumType=Card	_	_	_	_
9	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
10	through	through	ADP	IN	_	_	_	_	_
11	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
12	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
13	IL	Il	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
14	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
15	4	4	NUM	CD	NumType=Card	_	_	_	_
16	receptor	receptor	NOUN	NN	Number=Sing	_	_	_	_
17	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
18	IL	Il	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
19	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
20	4R	4r	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
21	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
22	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3680
# text = By functionally expressing receptor mutants in the murine pro-B cell line Ba/F3, we could show that phosphorylated tyrosine residues within the IL-4R alpha chain are dispensable for IL-4-induced STAT5 activity.
1	By	by	ADP	IN	_	_	_	_	_
2	functionally	functionally	ADV	RB	_	_	_	_	_
3	expressing	express	ADJ	JJ	Degree=Pos	_	_	_	_
4	receptor	receptor	NOUN	NN	Number=Sing	_	_	_	_
5	mutants	mutant	NOUN	NNS	Number=Plur	_	_	_	_
6	in	in	ADP	IN	_	_	_	_	_
7	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
8	murine	murine	NOUN	NN	Number=Sing	_	_	_	_
9	pro-B	pro-b	NOUN	NN	Number=Sing	_	_	_	_
10	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
11	line	line	NOUN	NN	Number=Sing	_	_	_	_
12	Ba/F3	Ba/F3	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
13	,	,	PUNCT	,	_	_	_	_	_
14	we	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
15	could	could	AUX	MD	VerbForm=Fin	_	_	_	_
16	show	show	VERB	VB	VerbForm=Inf	_	_	_	_
17	that	that	SCONJ	IN	_	_	_	_	_
18	phosphorylated	phosphorylate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
19	tyrosine	tyrosine	NOUN	NN	Number=Sing	_	_	_	_
20	residues	residue	NOUN	NNS	Number=Plur	_	_	_	_
21	within	within	ADP	IN	_	_	_	_	_
22	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
23	IL	Il	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
24	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
25	4R	4r	PROPN	NNP	Number=Sing	_	_	_	_
26	alpha	alpha	NOUN	NN	Number=Sing	_	_	_	_
27	chain	chain	NOUN	NN	Number=Sing	_	_	_	_
28	are	be	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
29	dispensable	dispensable	ADJ	JJ	Degree=Pos	_	_	_	_
30	for	for	ADP	IN	_	_	_	_	_
31	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
32	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
33	4	4	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
34	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
35	induced	induce	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
36	STAT5	stat5	NUM	CD	NumType=Card	_	_	_	_
37	activity	activity	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
38	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3681
# text = However, disruption of a membrane-proximal proline-rich sequence motif ('box1') in either subunit of the bipartite IL-4R abolished not only ligand-induced tyrosine phosphorylation of Janus kinases JAK1 and JAK3, but also IL-4-triggered activation of STAT5 and concomitant cell proliferation.
1	However	however	ADV	RB	_	_	_	_	SpaceAfter=No
2	,	,	PUNCT	,	_	_	_	_	_
3	disruption	disruption	NOUN	NN	Number=Sing	_	_	_	_
4	of	of	ADP	IN	_	_	_	_	_
5	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
6	membrane	membrane	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
7	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
8	proximal	proximal	ADJ	JJ	Degree=Pos	_	_	_	_
9	proline	proline	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
10	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
11	rich	rich	ADJ	JJ	Degree=Pos	_	_	_	_
12	sequence	sequence	NOUN	NN	Number=Sing	_	_	_	_
13	motif	motif	NOUN	NN	Number=Sing	_	_	_	_
14	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
15	'	'	PUNCT	``	_	_	_	_	SpaceAfter=No
16	box1	box1	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
17	'	'	PUNCT	''	_	_	_	_	SpaceAfter=No
18	)	)	PUNCT	-RRB-	_	_	_	_	_
19	in	in	ADP	IN	_	_	_	_	_
20	either	either	DET	DT	_	_	_	_	_
21	subunit	subunit	NOUN	NN	Number=Sing	_	_	_	_
22	of	of	ADP	IN	_	_	_	_	_
23	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
24	bipartite	bipartite	ADJ	JJ	Degree=Pos	_	_	_	_
25	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
26	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
27	4R	4R	PROPN	NNP	Number=Sing	_	_	_	_
28	abolished	abolish	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
29	not	not	ADV	RB	_	_	_	_	_
30	only	only	ADV	RB	_	_	_	_	_
31	ligand	ligand	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
32	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
33	induced	induce	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
34	tyrosine	tyrosine	NOUN	NN	Number=Sing	_	_	_	_
35	phosphorylation	phosphorylation	NOUN	NN	Number=Sing	_	_	_	_
36	of	of	ADP	IN	_	_	_	_	_
37	Janus	Janus	PROPN	NNP	Number=Sing	_	_	_	_
38	kinases	kinase	NOUN	NNS	Number=Plur	_	_	_	_
39	JAK1	JAK1	NUM	CD	NumType=Card	_	_	_	_
40	and	and	CCONJ	CC	_	_	_	_	_
41	JAK3	JAK3	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
42	,	,	PUNCT	,	_	_	_	_	_
43	but	but	CCONJ	CC	_	_	_	_	_
44	also	also	ADV	RB	_	_	_	_	_
45	IL	Il	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
46	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
47	4	4	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
48	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
49	triggered	trigger	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
50	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
51	of	of	ADP	IN	_	_	_	_	_
52	STAT5	stat5	PROPN	NNP	Number=Sing	_	_	_	_
53	and	and	CCONJ	CC	_	_	_	_	_
54	concomitant	concomitant	ADJ	JJ	Degree=Pos	_	_	_	_
55	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
56	proliferation	proliferation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
57	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3682
# text = A dominant-negative version of STAT5b, but not of STAT5a, interfered with IL-4-induced DNA synthesis in Ba/F3 cells, suggesting an involvement of STAT5b in the control of cell proliferation through IL-4R.
1	A	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
2	dominant	dominant	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
3	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
4	negative	negative	ADJ	JJ	Degree=Pos	_	_	_	_
5	version	version	NOUN	NN	Number=Sing	_	_	_	_
6	of	of	ADP	IN	_	_	_	_	_
7	STAT5	STAT5	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
8	b	b	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
9	,	,	PUNCT	,	_	_	_	_	_
10	but	but	CCONJ	CC	_	_	_	_	_
11	not	not	ADV	RB	_	_	_	_	_
12	of	of	ADP	IN	_	_	_	_	_
13	STAT5a	STAT5a	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
14	,	,	PUNCT	,	_	_	_	_	_
15	interfered	interfer	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
16	with	with	ADP	IN	_	_	_	_	_
17	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
18	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
19	4	4	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
20	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
21	induced	induce	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
22	DNA	dna	NOUN	NN	Number=Sing	_	_	_	_
23	synthesis	synthesis	NOUN	NN	Number=Sing	_	_	_	_
24	in	in	ADP	IN	_	_	_	_	_
25	Ba/F3	Ba/F3	NUM	CD	NumType=Card	_	_	_	_
26	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
27	,	,	PUNCT	,	_	_	_	_	_
28	suggesting	suggest	VERB	VBG	VerbForm=Ger	_	_	_	_
29	an	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
30	involvement	involvement	NOUN	NN	Number=Sing	_	_	_	_
31	of	of	ADP	IN	_	_	_	_	_
32	STAT5	STAT5	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
33	b	b	NOUN	NN	Number=Sing	_	_	_	_
34	in	in	ADP	IN	_	_	_	_	_
35	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
36	control	control	NOUN	NN	Number=Sing	_	_	_	_
37	of	of	ADP	IN	_	_	_	_	_
38	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
39	proliferation	proliferation	NOUN	NN	Number=Sing	_	_	_	_
40	through	through	ADP	IN	_	_	_	_	_
41	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
42	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
43	4R	4R	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
44	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3683
# text = Reporter gene experiments finally showed that transcription from promoters of STAT5 target genes can be specifically induced by challenging cells with IL-4, and that both STAT5a and STAT5b can contribute to IL-4-triggered transcriptional control.
1	Reporter	reporter	NOUN	NN	Number=Sing	_	_	_	_
2	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
3	experiments	experiment	NOUN	NNS	Number=Plur	_	_	_	_
4	finally	finally	ADV	RB	_	_	_	_	_
5	showed	show	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
6	that	that	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
7	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
8	from	from	ADP	IN	_	_	_	_	_
9	promoters	promoter	NOUN	NNS	Number=Plur	_	_	_	_
10	of	of	ADP	IN	_	_	_	_	_
11	STAT5	STAT5	NUM	CD	NumType=Card	_	_	_	_
12	target	target	NOUN	NN	Number=Sing	_	_	_	_
13	genes	gene	NOUN	NNS	Number=Plur	_	_	_	_
14	can	can	AUX	MD	VerbForm=Fin	_	_	_	_
15	be	be	AUX	VB	VerbForm=Inf	_	_	_	_
16	specifically	specifically	ADV	RB	_	_	_	_	_
17	induced	induce	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
18	by	by	ADP	IN	_	_	_	_	_
19	challenging	challenging	ADJ	JJ	Degree=Pos	_	_	_	_
20	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
21	with	with	ADP	IN	_	_	_	_	_
22	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
23	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
24	4	4	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
25	,	,	PUNCT	,	_	_	_	_	_
26	and	and	CCONJ	CC	_	_	_	_	_
27	that	that	SCONJ	IN	_	_	_	_	_
28	both	both	DET	DT	_	_	_	_	_
29	STAT5	STAT5	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
30	a	a	NOUN	NN	Number=Sing	_	_	_	_
31	and	and	CCONJ	CC	_	_	_	_	_
32	STAT5	stat5	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
33	b	b	NOUN	NN	Number=Sing	_	_	_	_
34	can	can	AUX	MD	VerbForm=Fin	_	_	_	_
35	contribute	contribute	VERB	VB	VerbForm=Inf	_	_	_	_
36	to	to	ADP	IN	_	_	_	_	_
37	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
38	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
39	4	4	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
40	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
41	triggered	trigger	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
42	transcriptional	transcriptional	ADJ	JJ	Degree=Pos	_	_	_	_
43	control	control	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
44	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 3684
# text = Document 003003539 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	003003539	003003539	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 3685
# text = HTLV-1 Tax induces expression of various immediate early serum responsive genes.
1	HTLV	HTLV	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
2	-	-	PUNCT	:	_	_	_	_	SpaceAfter=No
3	1	1	NUM	CD	NumType=Card	_	_	_	_
4	Tax	tax	NOUN	NN	Number=Sing	_	_	_	_
5	induces	induce	NOUN	NNS	Number=Plur	_	_	_	_
6	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
7	of	of	ADP	IN	_	_	_	_	_
8	various	various	ADJ	JJ	Degree=Pos	_	_	_	_
9	immediate	immediate	ADJ	JJ	Degree=Pos	_	_	_	_
10	early	early	ADJ	JJ	Degree=Pos	_	_	_	_
11	serum	serum	NOUN	NN	Number=Sing	_	_	_	_
12	responsive	responsive	ADJ	JJ	Degree=Pos	_	_	_	_
13	genes	gene	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
14	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 3686
# text = Human T-cell leukemia virus type 1 (HTLV-1) is an etiological agent of adult T-cell leukemia (ATL).
1	Human	human	ADJ	JJ	Degree=Pos	_	_	_	_
2	T-	t-	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
3	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
4	leukemia	leukemia	NOUN	NN	Number=Sing	_	_	_	_
5	virus	virus	NOUN	NN	Number=Sing	_	_	_	_
6	type	type	NOUN	NN	Number=Sing	_	_	_	_
7	1	1	NUM	CD	NumType=Card	_	_	_	_
8	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
9	HTLV	HTLV	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
10	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
11	1	1	X	LS	_	_	_	_	SpaceAfter=No
12	)	)	PUNCT	-RRB-	_	_	_	_	_
13	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
14	an	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
15	etiological	etiological	ADJ	JJ	Degree=Pos	_	_	_	_
16	agent	agent	NOUN	NN	Number=Sing	_	_	_	_
17	of	of	ADP	IN	_	_	_	_	_
18	adult	adult	NOUN	NN	Number=Sing	_	_	_	_
19	T-	T-	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
20	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
21	leukemia	leukemia	NOUN	NN	Number=Sing	_	_	_	_
22	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
23	ATL	ATL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
24	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
25	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3687
# text = We showed here by mobility-shift assay that T-cell lines transformed with the virus contained high levels of AP-1 activities.
1	We	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
2	showed	show	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
3	here	here	ADV	RB	PronType=Dem	_	_	_	_
4	by	by	ADP	IN	_	_	_	_	_
5	mobility	mobility	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
6	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
7	shift	shift	NOUN	NN	Number=Sing	_	_	_	_
8	assay	assay	NOUN	NN	Number=Sing	_	_	_	_
9	that	that	PRON	WDT	PronType=Rel	_	_	_	_
10	T-	T-	SYM	NFP	_	_	_	_	SpaceAfter=No
11	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
12	lines	line	NOUN	NNS	Number=Plur	_	_	_	_
13	transformed	transform	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
14	with	with	ADP	IN	_	_	_	_	_
15	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
16	virus	virus	NOUN	NN	Number=Sing	_	_	_	_
17	contained	contain	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
18	high	high	ADJ	JJ	Degree=Pos	_	_	_	_
19	levels	level	NOUN	NNS	Number=Plur	_	_	_	_
20	of	of	ADP	IN	_	_	_	_	_
21	AP	ap	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
22	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
23	1	1	NUM	CD	NumType=Card	_	_	_	_
24	activities	activity	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
25	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3688
# text = Consistent with this result, these cell lines expressed increased levels of mRNAs encoding the AP-1 proteins, c-Fos, Fra-1, c-Jun, JunB, and JunD.
1	Consistent	consistent	ADJ	JJ	Degree=Pos	_	_	_	_
2	with	with	ADP	IN	_	_	_	_	_
3	this	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
4	result	result	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
5	,	,	PUNCT	,	_	_	_	_	_
6	these	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
7	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
8	lines	line	NOUN	NNS	Number=Plur	_	_	_	_
9	expressed	express	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
10	increased	increase	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
11	levels	level	NOUN	NNS	Number=Plur	_	_	_	_
12	of	of	ADP	IN	_	_	_	_	_
13	mRNAs	mRNA	SCONJ	IN	_	_	_	_	_
14	encoding	encod	VERB	VBG	VerbForm=Ger	_	_	_	_
15	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
16	AP	ap	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
17	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
18	1	1	NUM	CD	NumType=Card	_	_	_	_
19	proteins	protein	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
20	,	,	PUNCT	,	_	_	_	_	_
21	c-	c-	SYM	NFP	_	_	_	_	SpaceAfter=No
22	Fos	Fos	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
23	,	,	PUNCT	,	_	_	_	_	_
24	Fra	Fra	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
25	-1	-1	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
26	,	,	PUNCT	,	_	_	_	_	_
27	c	c	NOUN	NN	Abbr=Yes|Number=Sing	_	_	_	SpaceAfter=No
28	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
29	Jun	Jun	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
30	,	,	PUNCT	,	_	_	_	_	_
31	JunB	JunB	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
32	,	,	PUNCT	,	_	_	_	_	_
33	and	and	CCONJ	CC	_	_	_	_	_
34	JunD	JunD	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
35	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3689
# text = Previously, transcription of the c-fos gene has been reported to be transactivated by the viral transcription factor, Tax1.
1	Previously	previously	ADV	RB	_	_	_	_	SpaceAfter=No
2	,	,	PUNCT	,	_	_	_	_	_
3	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
4	of	of	ADP	IN	_	_	_	_	_
5	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
6	c	c	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
7	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
8	fos	fo	NOUN	NNS	Number=Plur	_	_	_	_
9	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
10	has	have	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
11	been	be	AUX	VBN	Tense=Past|VerbForm=Part	_	_	_	_
12	reported	report	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
13	to	to	PART	TO	_	_	_	_	_
14	be	be	AUX	VB	VerbForm=Inf	_	_	_	_
15	transactivated	transactivate	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
16	by	by	ADP	IN	_	_	_	_	_
17	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
18	viral	viral	ADJ	JJ	Degree=Pos	_	_	_	_
19	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
20	factor	factor	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
21	,	,	PUNCT	,	_	_	_	_	_
22	Tax1	Tax1	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
23	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3690
# text = By using the human T-cell line (JPX-9), in which expression of the Tax1 is inducible, we showed that expression of mRNAs for Fra-1, c-Jun, and JunD was also transactivated by Tax1.
1	By	by	SCONJ	IN	_	_	_	_	_
2	using	use	VERB	VBG	VerbForm=Ger	_	_	_	_
3	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
4	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
5	T-	t-	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
6	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
7	line	line	NOUN	NN	Number=Sing	_	_	_	_
8	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
9	JPX	JPX	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
10	-	-	SYM	SYM	_	_	_	_	SpaceAfter=No
11	9	9	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
12	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
13	,	,	PUNCT	,	_	_	_	_	_
14	in	in	ADP	IN	_	_	_	_	_
15	which	which	DET	WDT	PronType=Int	_	_	_	_
16	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
17	of	of	ADP	IN	_	_	_	_	_
18	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
19	Tax1	tax1	NOUN	NN	Number=Sing	_	_	_	_
20	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
21	inducible	inducible	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
22	,	,	PUNCT	,	_	_	_	_	_
23	we	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
24	showed	show	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
25	that	that	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
26	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
27	of	of	ADP	IN	_	_	_	_	_
28	mRNAs	mRNAs	NOUN	NNS	Number=Plur	_	_	_	_
29	for	for	ADP	IN	_	_	_	_	_
30	Fra	Fra	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
31	-1	-1	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
32	,	,	PUNCT	,	_	_	_	_	_
33	c	c	NOUN	NN	Abbr=Yes|Number=Sing	_	_	_	SpaceAfter=No
34	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
35	Jun	Jun	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
36	,	,	PUNCT	,	_	_	_	_	_
37	and	and	CCONJ	CC	_	_	_	_	_
38	JunD	JunD	PROPN	NNP	Number=Sing	_	_	_	_
39	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
40	also	also	ADV	RB	_	_	_	_	_
41	transactivated	transactivate	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
42	by	by	ADP	IN	_	_	_	_	_
43	Tax1	Tax1	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
44	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3691
# text = Moreover, Tax1 activated expression of two other transcription factors having zinc finger motifs, Egr-1 and Egr-2, in the same cells.
1	Moreover	moreover	ADV	RB	_	_	_	_	SpaceAfter=No
2	,	,	PUNCT	,	_	_	_	_	_
3	Tax1	Tax1	PROPN	NNP	Number=Sing	_	_	_	_
4	activated	activate	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
5	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
6	of	of	ADP	IN	_	_	_	_	_
7	two	two	NUM	CD	NumType=Card	_	_	_	_
8	other	other	ADJ	JJ	Degree=Pos	_	_	_	_
9	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
10	factors	factor	NOUN	NNS	Number=Plur	_	_	_	_
11	having	have	VERB	VBG	VerbForm=Ger	_	_	_	_
12	zinc	zinc	NOUN	NN	Number=Sing	_	_	_	_
13	finger	finger	NOUN	NN	Number=Sing	_	_	_	_
14	motifs	motif	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
15	,	,	PUNCT	,	_	_	_	_	_
16	Egr	Egr	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
17	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
18	1	1	NUM	CD	NumType=Card	_	_	_	_
19	and	and	CCONJ	CC	_	_	_	_	_
20	Egr	Egr	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
21	-2	-2	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
22	,	,	PUNCT	,	_	_	_	_	_
23	in	in	ADP	IN	_	_	_	_	_
24	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
25	same	same	ADJ	JJ	Degree=Pos	_	_	_	_
26	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
27	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3692
# text = The Tax1-inducible transcription factors identified here are encoded by the members of immediate early genes under the control of growth signals.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	Tax1	tax1	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
3	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
4	inducible	inducible	ADJ	JJ	Degree=Pos	_	_	_	_
5	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
6	factors	factor	NOUN	NNS	Number=Plur	_	_	_	_
7	identified	identify	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
8	here	here	ADV	RB	PronType=Dem	_	_	_	_
9	are	be	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
10	encoded	encod	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
11	by	by	ADP	IN	_	_	_	_	_
12	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
13	members	member	NOUN	NNS	Number=Plur	_	_	_	_
14	of	of	ADP	IN	_	_	_	_	_
15	immediate	immediate	ADJ	JJ	Degree=Pos	_	_	_	_
16	early	early	ADJ	JJ	Degree=Pos	_	_	_	_
17	genes	gene	NOUN	NNS	Number=Plur	_	_	_	_
18	under	under	ADP	IN	_	_	_	_	_
19	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
20	control	control	NOUN	NN	Number=Sing	_	_	_	_
21	of	of	ADP	IN	_	_	_	_	_
22	growth	growth	NOUN	NN	Number=Sing	_	_	_	_
23	signals	signal	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
24	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3693
# text = Thus, Tax1 was suggested to replace growth signals, at least in part, by this mechanism.
1	Thus	thus	ADV	RB	_	_	_	_	SpaceAfter=No
2	,	,	PUNCT	,	_	_	_	_	_
3	Tax1	Tax1	PROPN	NNP	Number=Sing	_	_	_	_
4	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
5	suggested	suggest	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
6	to	to	PART	TO	_	_	_	_	_
7	replace	replace	VERB	VB	VerbForm=Inf	_	_	_	_
8	growth	growth	NOUN	NN	Number=Sing	_	_	_	_
9	signals	signal	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
10	,	,	PUNCT	,	_	_	_	_	_
11	at	at	ADV	RB	_	_	_	_	_
12	least	least	ADV	RBS	Degree=Sup	_	_	_	_
13	in	in	ADP	IN	_	_	_	_	_
14	part	part	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
15	,	,	PUNCT	,	_	_	_	_	_
16	by	by	ADP	IN	_	_	_	_	_
17	this	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
18	mechanism	mechanism	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
19	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 3694
# text = Document 003003541 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	003003541	003003541	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 3695
# text = Monoallelic expression of Pax5: a paradigm for the haploinsufficiency of mammalian Pax genes?
1	Monoallelic	Monoallelic	ADJ	JJ	Degree=Pos	_	_	_	_
2	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
3	of	of	ADP	IN	_	_	_	_	_
4	Pax5	Pax5	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
5	:	:	PUNCT	:	_	_	_	_	_
6	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
7	paradigm	paradigm	NOUN	NN	Number=Sing	_	_	_	_
8	for	for	ADP	IN	_	_	_	_	_
9	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
10	haploinsufficiency	haploinsufficiency	NOUN	NN	Number=Sing	_	_	_	_
11	of	of	ADP	IN	_	_	_	_	_
12	mammalian	mammalian	ADJ	JJ	Degree=Pos	_	_	_	_
13	Pax	Pax	NOUN	NN	Number=Sing	_	_	_	_
14	genes	gene	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
15	?	?	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 3696
# text = It is generally assumed that most mammalian genes are transcribed from both alleles.
1	It	it	PRON	PRP	Case=Nom|Gender=Neut|Number=Sing|Person=3|PronType=Prs	_	_	_	_
2	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
3	generally	generally	ADV	RB	_	_	_	_	_
4	assumed	assume	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
5	that	that	SCONJ	IN	_	_	_	_	_
6	most	most	ADJ	JJS	Degree=Sup	_	_	_	_
7	mammalian	mammalian	ADJ	JJ	Degree=Pos	_	_	_	_
8	genes	gene	NOUN	NNS	Number=Plur	_	_	_	_
9	are	be	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
10	transcribed	transcribe	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
11	from	from	ADP	IN	_	_	_	_	_
12	both	both	DET	DT	_	_	_	_	_
13	alleles	allele	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
14	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3697
# text = Hence, the diploid state of the genome offers the advantage that a loss-of-function mutation in one allele can be compensated for by the remaining wild-type allele of the same gene.
1	Hence	hence	ADV	RB	_	_	_	_	SpaceAfter=No
2	,	,	PUNCT	,	_	_	_	_	_
3	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
4	diploid	diploid	ADJ	JJ	Degree=Pos	_	_	_	_
5	state	state	NOUN	NN	Number=Sing	_	_	_	_
6	of	of	ADP	IN	_	_	_	_	_
7	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
8	genome	genome	NOUN	NN	Number=Sing	_	_	_	_
9	offers	offer	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
10	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
11	advantage	advantage	NOUN	NN	Number=Sing	_	_	_	_
12	that	that	PRON	WDT	PronType=Rel	_	_	_	_
13	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
14	loss	loss	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
15	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
16	of	of	ADP	IN	_	_	_	_	SpaceAfter=No
17	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
18	function	function	NOUN	NN	Number=Sing	_	_	_	_
19	mutation	mutation	NOUN	NN	Number=Sing	_	_	_	_
20	in	in	ADP	IN	_	_	_	_	_
21	one	one	NUM	CD	NumType=Card	_	_	_	_
22	allele	allele	NOUN	NN	Number=Sing	_	_	_	_
23	can	can	AUX	MD	VerbForm=Fin	_	_	_	_
24	be	be	AUX	VB	VerbForm=Inf	_	_	_	_
25	compensated	compensate	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
26	for	for	ADP	IN	_	_	_	_	_
27	by	by	ADP	IN	_	_	_	_	_
28	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
29	remaining	remain	VERB	VBG	VerbForm=Ger	_	_	_	_
30	wild	wild	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
31	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
32	type	type	NOUN	NN	Number=Sing	_	_	_	_
33	allele	allele	NOUN	NN	Number=Sing	_	_	_	_
34	of	of	ADP	IN	_	_	_	_	_
35	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
36	same	same	ADJ	JJ	Degree=Pos	_	_	_	_
37	gene	gene	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
38	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3698
# text = Indeed, the vast majority of human disease syndromes and engineered mutations in the mouse genome are recessive, indicating that recessiveness is the 'default' state.
1	Indeed	indeed	ADV	RB	_	_	_	_	SpaceAfter=No
2	,	,	PUNCT	,	_	_	_	_	_
3	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
4	vast	vast	ADJ	JJ	Degree=Pos	_	_	_	_
5	majority	majority	NOUN	NN	Number=Sing	_	_	_	_
6	of	of	ADP	IN	_	_	_	_	_
7	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
8	disease	disease	NOUN	NN	Number=Sing	_	_	_	_
9	syndromes	syndrome	NOUN	NNS	Number=Plur	_	_	_	_
10	and	and	CCONJ	CC	_	_	_	_	_
11	engineered	engineer	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
12	mutations	mutation	NOUN	NNS	Number=Plur	_	_	_	_
13	in	in	ADP	IN	_	_	_	_	_
14	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
15	mouse	mouse	NOUN	NN	Number=Sing	_	_	_	_
16	genome	genome	NOUN	NN	Number=Sing	_	_	_	_
17	are	be	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
18	recessive	recessive	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
19	,	,	PUNCT	,	_	_	_	_	_
20	indicating	indicate	VERB	VBG	VerbForm=Ger	_	_	_	_
21	that	that	SCONJ	IN	_	_	_	_	_
22	recessiveness	recessiveness	NOUN	NN	Number=Sing	_	_	_	_
23	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
24	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
25	'	'	PUNCT	``	_	_	_	_	SpaceAfter=No
26	default	default	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
27	'	'	PUNCT	''	_	_	_	_	_
28	state	state	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
29	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3699
# text = However, a minority of genes are semi-dominant, as heterozygous loss-of-function mutation in these genes leads to phenotypic abnormalities.
1	However	however	ADV	RB	_	_	_	_	SpaceAfter=No
2	,	,	PUNCT	,	_	_	_	_	_
3	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
4	minority	minority	NOUN	NN	Number=Sing	_	_	_	_
5	of	of	ADP	IN	_	_	_	_	_
6	genes	gene	NOUN	NNS	Number=Plur	_	_	_	_
7	are	be	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
8	semi-dominant	semi-dominant	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
9	,	,	PUNCT	,	_	_	_	_	_
10	as	as	SCONJ	IN	_	_	_	_	_
11	heterozygous	heterozygous	ADJ	JJ	Degree=Pos	_	_	_	_
12	loss	lose	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
13	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
14	of	of	ADP	IN	_	_	_	_	SpaceAfter=No
15	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
16	function	function	NOUN	NN	Number=Sing	_	_	_	_
17	mutation	mutation	NOUN	NN	Number=Sing	_	_	_	_
18	in	in	ADP	IN	_	_	_	_	_
19	these	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
20	genes	gene	NOUN	NNS	Number=Plur	_	_	_	_
21	leads	lead	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
22	to	to	ADP	IN	_	_	_	_	_
23	phenotypic	phenotypic	ADJ	JJ	Degree=Pos	_	_	_	_
24	abnormalities	abnormality	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
25	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3700
# text = This condition, known as haploinsufficiency, has been described for five of the nine mammalian Pax genes, which are associated with mouse developmental mutants and human disease syndromes.
1	This	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
2	condition	condition	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
3	,	,	PUNCT	,	_	_	_	_	_
4	known	know	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
5	as	as	ADP	IN	_	_	_	_	_
6	haploinsufficiency	haploinsufficiency	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
7	,	,	PUNCT	,	_	_	_	_	_
8	has	have	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
9	been	be	AUX	VBN	Tense=Past|VerbForm=Part	_	_	_	_
10	described	describe	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
11	for	for	ADP	IN	_	_	_	_	_
12	five	five	NUM	CD	NumType=Card	_	_	_	_
13	of	of	ADP	IN	_	_	_	_	_
14	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
15	nine	nine	NUM	CD	NumType=Card	_	_	_	_
16	mammalian	mammalian	ADJ	JJ	Degree=Pos	_	_	_	_
17	Pax	Pax	NOUN	NN	Number=Sing	_	_	_	_
18	genes	gene	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
19	,	,	PUNCT	,	_	_	_	_	_
20	which	which	PRON	WDT	PronType=Rel	_	_	_	_
21	are	be	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
22	associated	associate	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
23	with	with	ADP	IN	_	_	_	_	_
24	mouse	mouse	NOUN	NN	Number=Sing	_	_	_	_
25	developmental	developmental	ADJ	JJ	Degree=Pos	_	_	_	_
26	mutants	mutant	NOUN	NNS	Number=Plur	_	_	_	_
27	and	and	CCONJ	CC	_	_	_	_	_
28	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
29	disease	disease	NOUN	NN	Number=Sing	_	_	_	_
30	syndromes	syndrome	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
31	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3701
# text = Recently we have reported that the Pax5 gene is subject to allele-specific regulation during B cell development.
1	Recently	recently	ADV	RB	_	_	_	_	_
2	we	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
3	have	have	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
4	reported	report	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
5	that	that	SCONJ	IN	_	_	_	_	_
6	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
7	Pax5	pax5	NOUN	NN	Number=Sing	_	_	_	_
8	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
9	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
10	subject	subject	ADJ	JJ	Degree=Pos	_	_	_	_
11	to	to	ADP	IN	_	_	_	_	_
12	allele	allele	ADV	RB	_	_	_	_	SpaceAfter=No
13	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
14	specific	specific	ADJ	JJ	Degree=Pos	_	_	_	_
15	regulation	regulation	NOUN	NN	Number=Sing	_	_	_	_
16	during	during	ADP	IN	_	_	_	_	_
17	B	b	ADJ	JJ	Degree=Pos	_	_	_	_
18	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
19	development	development	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
20	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3702
# text = Pax5 is predominantly transcribed from only one of its two alleles in early B-lymphoid progenitors and mature B cells, while it transiently switches to a biallelic mode of transcription in pre-B and immature B cells.
1	Pax5	pax5	NOUN	NN	Number=Sing	_	_	_	_
2	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
3	predominantly	predominantly	ADV	RB	_	_	_	_	_
4	transcribed	transcribe	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
5	from	from	ADP	IN	_	_	_	_	_
6	only	only	ADV	RB	_	_	_	_	_
7	one	one	NUM	CD	NumType=Card	_	_	_	_
8	of	of	ADP	IN	_	_	_	_	_
9	its	its	PRON	PRP$	Gender=Neut|Number=Sing|Person=3|Poss=Yes|PronType=Prs	_	_	_	_
10	two	two	NUM	CD	NumType=Card	_	_	_	_
11	alleles	allele	NOUN	NNS	Number=Plur	_	_	_	_
12	in	in	ADP	IN	_	_	_	_	_
13	early	early	ADJ	JJ	Degree=Pos	_	_	_	_
14	B	b	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
15	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
16	lymphoid	lymphoid	NOUN	NN	Number=Sing	_	_	_	_
17	progenitors	progenitor	NOUN	NNS	Number=Plur	_	_	_	_
18	and	and	CCONJ	CC	_	_	_	_	_
19	mature	mature	ADJ	JJ	Degree=Pos	_	_	_	_
20	B	b	ADJ	JJ	Degree=Pos	_	_	_	_
21	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
22	,	,	PUNCT	,	_	_	_	_	_
23	while	while	SCONJ	IN	_	_	_	_	_
24	it	it	PRON	PRP	Case=Nom|Gender=Neut|Number=Sing|Person=3|PronType=Prs	_	_	_	_
25	transiently	transiently	ADV	RB	_	_	_	_	_
26	switches	switch	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
27	to	to	ADP	IN	_	_	_	_	_
28	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
29	biallelic	biallelic	ADJ	JJ	Degree=Pos	_	_	_	_
30	mode	mode	NOUN	NN	Number=Sing	_	_	_	_
31	of	of	ADP	IN	_	_	_	_	_
32	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
33	in	in	ADP	IN	_	_	_	_	_
34	pre	pre	X	AFX	_	_	_	_	SpaceAfter=No
35	-B	-b	ADJ	JJ	Degree=Pos	_	_	_	_
36	and	and	CCONJ	CC	_	_	_	_	_
37	immature	immature	ADJ	JJ	Degree=Pos	_	_	_	_
38	B	b	ADJ	JJ	Degree=Pos	_	_	_	_
39	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
40	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3703
# text = As a consequence, B-lymphoid tissues are mosaic with regard to the transcribed allele, and heterozygous mutation of Pax5 therefore results in deletion of B lymphocytes expressing only the mutant allele.
1	As	as	ADP	IN	_	_	_	_	_
2	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
3	consequence	consequence	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
4	,	,	PUNCT	,	_	_	_	_	_
5	B	b	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
6	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
7	lymphoid	lymphoid	NOUN	NN	Number=Sing	_	_	_	_
8	tissues	tissue	NOUN	NNS	Number=Plur	_	_	_	_
9	are	be	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
10	mosaic	mosaic	ADJ	JJ	Degree=Pos	_	_	_	_
11	with	with	ADP	IN	_	_	_	_	_
12	regard	regard	NOUN	NN	Number=Sing	_	_	_	_
13	to	to	ADP	IN	_	_	_	_	_
14	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
15	transcribed	transcribe	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
16	allele	allele	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
17	,	,	PUNCT	,	_	_	_	_	_
18	and	and	CCONJ	CC	_	_	_	_	_
19	heterozygous	heterozygous	ADJ	JJ	Degree=Pos	_	_	_	_
20	mutation	mutation	NOUN	NN	Number=Sing	_	_	_	_
21	of	of	ADP	IN	_	_	_	_	_
22	Pax5	pax5	PROPN	NNP	Number=Sing	_	_	_	_
23	therefore	therefore	ADV	RB	_	_	_	_	_
24	results	result	NOUN	NNS	Number=Plur	_	_	_	_
25	in	in	ADP	IN	_	_	_	_	_
26	deletion	deletion	NOUN	NN	Number=Sing	_	_	_	_
27	of	of	ADP	IN	_	_	_	_	_
28	B	b	ADJ	JJ	Degree=Pos	_	_	_	_
29	lymphocytes	lymphocyte	NOUN	NNS	Number=Plur	_	_	_	_
30	expressing	expresse	VERB	VBG	VerbForm=Ger	_	_	_	_
31	only	only	ADV	RB	_	_	_	_	_
32	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
33	mutant	mutant	ADJ	JJ	Degree=Pos	_	_	_	_
34	allele	allele	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
35	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3704
# text = The allele-specific regulation of Pax5 raises the intriguing possibility that monoallelic expression may also be the mechanism causing the haploinsufficiency of other Pax genes.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	allele	allele	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
3	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
4	specific	specific	ADJ	JJ	Degree=Pos	_	_	_	_
5	regulation	regulation	NOUN	NN	Number=Sing	_	_	_	_
6	of	of	ADP	IN	_	_	_	_	_
7	Pax5	Pax5	NUM	CD	NumType=Card	_	_	_	_
8	raises	rais	NOUN	NNS	Number=Plur	_	_	_	_
9	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
10	intriguing	intrigue	VERB	VBG	VerbForm=Ger	_	_	_	_
11	possibility	possibility	NOUN	NN	Number=Sing	_	_	_	_
12	that	that	SCONJ	IN	_	_	_	_	_
13	monoallelic	monoallelic	ADJ	JJ	Degree=Pos	_	_	_	_
14	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
15	may	may	AUX	MD	VerbForm=Fin	_	_	_	_
16	also	also	ADV	RB	_	_	_	_	_
17	be	be	AUX	VB	VerbForm=Inf	_	_	_	_
18	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
19	mechanism	mechanism	NOUN	NN	Number=Sing	_	_	_	_
20	causing	cause	VERB	VBG	VerbForm=Ger	_	_	_	_
21	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
22	haploinsufficiency	haploinsufficiency	NOUN	NN	Number=Sing	_	_	_	_
23	of	of	ADP	IN	_	_	_	_	_
24	other	other	ADJ	JJ	Degree=Pos	_	_	_	_
25	Pax	Pax	NOUN	NN	Number=Sing	_	_	_	_
26	genes	gene	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
27	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3705
# text = In this review, we discuss different models accounting for the haploinsufficiency of mammalian Pax genes, provide further evidence in support of the allele-specific regulation of Pax5 and discuss the implication of these findings in the context of the recent literature describing the stochastic and monoallelic activation of other hematopoietic genes.
1	In	in	ADP	IN	_	_	_	_	_
2	this	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
3	review	review	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
4	,	,	PUNCT	,	_	_	_	_	_
5	we	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
6	discuss	discuss	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
7	different	different	ADJ	JJ	Degree=Pos	_	_	_	_
8	models	model	NOUN	NNS	Number=Plur	_	_	_	_
9	accounting	accounte	NOUN	NN	Number=Sing	_	_	_	_
10	for	for	ADP	IN	_	_	_	_	_
11	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
12	haploinsufficiency	haploinsufficiency	NOUN	NN	Number=Sing	_	_	_	_
13	of	of	ADP	IN	_	_	_	_	_
14	mammalian	mammalian	ADJ	JJ	Degree=Pos	_	_	_	_
15	Pax	Pax	NOUN	NN	Number=Sing	_	_	_	_
16	genes	gene	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
17	,	,	PUNCT	,	_	_	_	_	_
18	provide	provide	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
19	further	further	ADJ	JJ	Degree=Pos	_	_	_	_
20	evidence	evidence	NOUN	NN	Number=Sing	_	_	_	_
21	in	in	ADP	IN	_	_	_	_	_
22	support	support	NOUN	NN	Number=Sing	_	_	_	_
23	of	of	ADP	IN	_	_	_	_	_
24	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
25	allele	allele	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
26	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
27	specific	specific	ADJ	JJ	Degree=Pos	_	_	_	_
28	regulation	regulation	NOUN	NN	Number=Sing	_	_	_	_
29	of	of	ADP	IN	_	_	_	_	_
30	Pax5	Pax5	NUM	CD	NumType=Card	_	_	_	_
31	and	and	CCONJ	CC	_	_	_	_	_
32	discuss	discuss	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
33	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
34	implication	implication	NOUN	NN	Number=Sing	_	_	_	_
35	of	of	ADP	IN	_	_	_	_	_
36	these	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
37	findings	finding	NOUN	NNS	Number=Plur	_	_	_	_
38	in	in	ADP	IN	_	_	_	_	_
39	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
40	context	context	NOUN	NN	Number=Sing	_	_	_	_
41	of	of	ADP	IN	_	_	_	_	_
42	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
43	recent	recent	ADJ	JJ	Degree=Pos	_	_	_	_
44	literature	literature	NOUN	NN	Number=Sing	_	_	_	_
45	describing	describe	VERB	VBG	VerbForm=Ger	_	_	_	_
46	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
47	stochastic	stochastic	ADJ	JJ	Degree=Pos	_	_	_	_
48	and	and	CCONJ	CC	_	_	_	_	_
49	monoallelic	monoallelic	ADJ	JJ	Degree=Pos	_	_	_	_
50	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
51	of	of	ADP	IN	_	_	_	_	_
52	other	other	ADJ	JJ	Degree=Pos	_	_	_	_
53	hematopoietic	hematopoietic	ADJ	JJ	Degree=Pos	_	_	_	_
54	genes	gene	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
55	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 3706
# text = Document 003003546 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	003003546	003003546	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 3707
# text = [The effect of 24,25-dihydroxyvitamin D3 (dioxyvit) on Ca metabolism and immune status during chronic kidney failure]
1	[	[	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
2	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
3	effect	effect	NOUN	NN	Number=Sing	_	_	_	_
4	of	of	ADP	IN	_	_	_	_	_
5	24,25	24,25	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
6	-	-	PUNCT	:	_	_	_	_	SpaceAfter=No
7	dihydroxyvitamin	dihydroxyvitamin	NOUN	NN	Number=Sing	_	_	_	_
8	D3	D3	NOUN	NN	Number=Sing	_	_	_	_
9	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
10	dioxyvit	dioxyvit	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
11	)	)	PUNCT	-RRB-	_	_	_	_	_
12	on	on	ADP	IN	_	_	_	_	_
13	Ca	ca	NOUN	NN	Number=Sing	_	_	_	_
14	metabolism	metabolism	NOUN	NN	Number=Sing	_	_	_	_
15	and	and	CCONJ	CC	_	_	_	_	_
16	immune	immune	ADJ	JJ	Degree=Pos	_	_	_	_
17	status	status	NOUN	NN	Number=Sing	_	_	_	_
18	during	during	ADP	IN	_	_	_	_	_
19	chronic	chronic	ADJ	JJ	Degree=Pos	_	_	_	_
20	kidney	kidney	NOUN	NN	Number=Sing	_	_	_	_
21	failure	failure	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
22	]	]	PUNCT	-RRB-	_	_	_	_	SpacesAfter=\s\n

# sent_id = 3708
# text = Active metabolite of vitamin D3, 24R,25 (OH)2D3 (dioxyvit) was used at a daily dose of 100 micrograms in treatment of children affected with tubulointerstitial disease of kidney and with chronic glomerulonephritis under conditions of kidney insufficiency.
1	Active	active	ADJ	JJ	Degree=Pos	_	_	_	_
2	metabolite	metabolite	NOUN	NN	Number=Sing	_	_	_	_
3	of	of	ADP	IN	_	_	_	_	_
4	vitamin	vitamin	ADJ	JJ	Degree=Pos	_	_	_	_
5	D3	D3	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
6	,	,	PUNCT	,	_	_	_	_	_
7	24R,25	24R,25	NUM	CD	NumType=Card	_	_	_	_
8	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
9	OH	Oh	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
10	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
11	2D3	2D3	NUM	CD	NumType=Card	_	_	_	_
12	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
13	dioxyvit	dioxyvit	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
14	)	)	PUNCT	-RRB-	_	_	_	_	_
15	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
16	used	use	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
17	at	at	ADP	IN	_	_	_	_	_
18	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
19	daily	daily	ADJ	JJ	Degree=Pos	_	_	_	_
20	dose	dose	NOUN	NN	Number=Sing	_	_	_	_
21	of	of	ADP	IN	_	_	_	_	_
22	100	100	NUM	CD	NumType=Card	_	_	_	_
23	micrograms	microgram	NOUN	NNS	Number=Plur	_	_	_	_
24	in	in	ADP	IN	_	_	_	_	_
25	treatment	treatment	NOUN	NN	Number=Sing	_	_	_	_
26	of	of	ADP	IN	_	_	_	_	_
27	children	child	NOUN	NNS	Number=Plur	_	_	_	_
28	affected	affect	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
29	with	with	ADP	IN	_	_	_	_	_
30	tubulointerstitial	tubulointerstitial	ADJ	JJ	Degree=Pos	_	_	_	_
31	disease	disease	NOUN	NN	Number=Sing	_	_	_	_
32	of	of	ADP	IN	_	_	_	_	_
33	kidney	kidney	NOUN	NN	Number=Sing	_	_	_	_
34	and	and	CCONJ	CC	_	_	_	_	_
35	with	with	ADP	IN	_	_	_	_	_
36	chronic	chronic	ADJ	JJ	Degree=Pos	_	_	_	_
37	glomerulonephritis	glomerulonephritis	NOUN	NN	Number=Sing	_	_	_	_
38	under	under	ADP	IN	_	_	_	_	_
39	conditions	condition	NOUN	NNS	Number=Plur	_	_	_	_
40	of	of	ADP	IN	_	_	_	_	_
41	kidney	kidney	NOUN	NN	Number=Sing	_	_	_	_
42	insufficiency	insufficiency	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
43	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3709
# text = The drug exhibited distinct normalizing effect on patterns of calcium metabolism: increase of total and ionized Ca2+ and of 25-OHD, decrease in concentration of parath hormone and osteocalcine in blood serum as well as on immunological parameters: restoration of decreased content of T- and 0-lymphocytes.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	drug	drug	NOUN	NN	Number=Sing	_	_	_	_
3	exhibited	exhibit	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
4	distinct	distinct	ADJ	JJ	Degree=Pos	_	_	_	_
5	normalizing	normalizing	NOUN	NN	Number=Sing	_	_	_	_
6	effect	effect	NOUN	NN	Number=Sing	_	_	_	_
7	on	on	ADP	IN	_	_	_	_	_
8	patterns	pattern	NOUN	NNS	Number=Plur	_	_	_	_
9	of	of	ADP	IN	_	_	_	_	_
10	calcium	calcium	NOUN	NN	Number=Sing	_	_	_	_
11	metabolism	metabolism	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
12	:	:	PUNCT	:	_	_	_	_	_
13	increase	increase	NOUN	NN	Number=Sing	_	_	_	_
14	of	of	ADP	IN	_	_	_	_	_
15	total	total	ADJ	JJ	Degree=Pos	_	_	_	_
16	and	and	CCONJ	CC	_	_	_	_	_
17	ionized	ionize	ADJ	JJ	Degree=Pos	_	_	_	_
18	Ca2	Ca2	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
19	+	+	SYM	SYM	_	_	_	_	_
20	and	and	CCONJ	CC	_	_	_	_	_
21	of	of	ADP	IN	_	_	_	_	_
22	25	25	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
23	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
24	OHD	Ohd	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
25	,	,	PUNCT	,	_	_	_	_	_
26	decrease	decrease	NOUN	NN	Number=Sing	_	_	_	_
27	in	in	ADP	IN	_	_	_	_	_
28	concentration	concentration	NOUN	NN	Number=Sing	_	_	_	_
29	of	of	ADP	IN	_	_	_	_	_
30	parath	parath	NOUN	NN	Number=Sing	_	_	_	_
31	hormone	hormone	NOUN	NN	Number=Sing	_	_	_	_
32	and	and	CCONJ	CC	_	_	_	_	_
33	osteocalcine	osteocalcine	NOUN	NN	Number=Sing	_	_	_	_
34	in	in	ADP	IN	_	_	_	_	_
35	blood	blood	NOUN	NN	Number=Sing	_	_	_	_
36	serum	serum	NOUN	NN	Number=Sing	_	_	_	_
37	as	as	ADV	RB	_	_	_	_	_
38	well	well	ADV	RB	Degree=Pos	_	_	_	_
39	as	as	ADP	IN	_	_	_	_	_
40	on	on	ADP	IN	_	_	_	_	_
41	immunological	immunological	ADJ	JJ	Degree=Pos	_	_	_	_
42	parameters	parameter	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
43	:	:	PUNCT	:	_	_	_	_	_
44	restoration	restoration	NOUN	NN	Number=Sing	_	_	_	_
45	of	of	ADP	IN	_	_	_	_	_
46	decreased	decrease	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
47	content	content	NOUN	NN	Number=Sing	_	_	_	_
48	of	of	ADP	IN	_	_	_	_	_
49	T	t	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
50	-	-	PUNCT	,	_	_	_	_	_
51	and	and	CCONJ	CC	_	_	_	_	_
52	0	0	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
53	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
54	lymphocytes	lymphocyte	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
55	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3710
# text = Concentration of receptors of hormonal form of 1,25(OH)2D3 was found to be minimal in lymphocytes under conditions of chronic kidney insufficiency, while their expression, after the dioxyvit action, was detected only in patients with glomerulonephritis.
1	Concentration	concentration	NOUN	NN	Number=Sing	_	_	_	_
2	of	of	ADP	IN	_	_	_	_	_
3	receptors	receptor	NOUN	NNS	Number=Plur	_	_	_	_
4	of	of	ADP	IN	_	_	_	_	_
5	hormonal	hormonal	ADJ	JJ	Degree=Pos	_	_	_	_
6	form	form	NOUN	NN	Number=Sing	_	_	_	_
7	of	of	ADP	IN	_	_	_	_	_
8	1,25	1,25	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
9	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
10	OH	Oh	INTJ	UH	_	_	_	_	SpaceAfter=No
11	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
12	2D3	2D3	NOUN	NN	Number=Sing	_	_	_	_
13	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
14	found	find	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
15	to	to	PART	TO	_	_	_	_	_
16	be	be	AUX	VB	VerbForm=Inf	_	_	_	_
17	minimal	minimal	ADJ	JJ	Degree=Pos	_	_	_	_
18	in	in	ADP	IN	_	_	_	_	_
19	lymphocytes	lymphocyte	NOUN	NNS	Number=Plur	_	_	_	_
20	under	under	ADP	IN	_	_	_	_	_
21	conditions	condition	NOUN	NNS	Number=Plur	_	_	_	_
22	of	of	ADP	IN	_	_	_	_	_
23	chronic	chronic	ADJ	JJ	Degree=Pos	_	_	_	_
24	kidney	kidney	NOUN	NN	Number=Sing	_	_	_	_
25	insufficiency	insufficiency	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
26	,	,	PUNCT	,	_	_	_	_	_
27	while	while	SCONJ	IN	_	_	_	_	_
28	their	they	PRON	PRP$	Number=Plur|Person=3|Poss=Yes|PronType=Prs	_	_	_	_
29	expression	expression	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
30	,	,	PUNCT	,	_	_	_	_	_
31	after	after	ADP	IN	_	_	_	_	_
32	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
33	dioxyvit	dioxyvit	NOUN	NN	Number=Sing	_	_	_	_
34	action	action	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
35	,	,	PUNCT	,	_	_	_	_	_
36	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
37	detected	detect	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
38	only	only	ADV	RB	_	_	_	_	_
39	in	in	ADP	IN	_	_	_	_	_
40	patients	patient	NOUN	NN	Number=Sing	_	_	_	_
41	with	with	ADP	IN	_	_	_	_	_
42	glomerulonephritis	glomerulonephritis	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
43	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3711
# text = Specific calcitropic effect of dioxyvit with simultaneous correction of vitamin D deficiency were apparently responsible for high efficacy of the drug in treatment of calcium metabolism and immunity impairments in children with renal deteriorations at the step of chronic kidney insufficiency.
1	Specific	specific	ADJ	JJ	Degree=Pos	_	_	_	_
2	calcitropic	calcitropic	ADJ	JJ	Degree=Pos	_	_	_	_
3	effect	effect	NOUN	NN	Number=Sing	_	_	_	_
4	of	of	ADP	IN	_	_	_	_	_
5	dioxyvit	dioxyvit	NOUN	NN	Number=Sing	_	_	_	_
6	with	with	ADP	IN	_	_	_	_	_
7	simultaneous	simultaneous	ADJ	JJ	Degree=Pos	_	_	_	_
8	correction	correction	NOUN	NN	Number=Sing	_	_	_	_
9	of	of	ADP	IN	_	_	_	_	_
10	vitamin	vitamin	ADJ	JJ	Degree=Pos	_	_	_	_
11	D	would	NOUN	NN	Number=Sing	_	_	_	_
12	deficiency	deficiency	NOUN	NN	Number=Sing	_	_	_	_
13	were	be	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
14	apparently	apparently	ADV	RB	_	_	_	_	_
15	responsible	responsible	ADJ	JJ	Degree=Pos	_	_	_	_
16	for	for	ADP	IN	_	_	_	_	_
17	high	high	ADJ	JJ	Degree=Pos	_	_	_	_
18	efficacy	efficacy	NOUN	NN	Number=Sing	_	_	_	_
19	of	of	ADP	IN	_	_	_	_	_
20	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
21	drug	drug	NOUN	NN	Number=Sing	_	_	_	_
22	in	in	ADP	IN	_	_	_	_	_
23	treatment	treatment	NOUN	NN	Number=Sing	_	_	_	_
24	of	of	ADP	IN	_	_	_	_	_
25	calcium	calcium	NOUN	NN	Number=Sing	_	_	_	_
26	metabolism	metabolism	NOUN	NN	Number=Sing	_	_	_	_
27	and	and	CCONJ	CC	_	_	_	_	_
28	immunity	immunity	NOUN	NN	Number=Sing	_	_	_	_
29	impairments	impairment	NOUN	NNS	Number=Plur	_	_	_	_
30	in	in	ADP	IN	_	_	_	_	_
31	children	child	NOUN	NNS	Number=Plur	_	_	_	_
32	with	with	ADP	IN	_	_	_	_	_
33	renal	renal	ADJ	JJ	Degree=Pos	_	_	_	_
34	deteriorations	deterioration	NOUN	NNS	Number=Plur	_	_	_	_
35	at	at	ADP	IN	_	_	_	_	_
36	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
37	step	step	NOUN	NN	Number=Sing	_	_	_	_
38	of	of	ADP	IN	_	_	_	_	_
39	chronic	chronic	ADJ	JJ	Degree=Pos	_	_	_	_
40	kidney	kidney	NOUN	NN	Number=Sing	_	_	_	_
41	insufficiency	insufficiency	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
42	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 3712
# text = Document 003003547 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	003003547	003003547	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 3713
# text = Detection of intracellular phosphorylated STAT-1 by flow cytometry.
1	Detection	detection	NOUN	NN	Number=Sing	_	_	_	_
2	of	of	ADP	IN	_	_	_	_	_
3	intracellular	intracelular	ADJ	JJ	Degree=Pos	_	_	_	_
4	phosphorylated	phosphorylate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
5	STAT	Stat	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
6	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
7	1	1	NUM	CD	NumType=Card	_	_	_	_
8	by	by	ADP	IN	_	_	_	_	_
9	flow	flow	ADJ	JJ	Degree=Pos	_	_	_	_
10	cytometry	cytometry	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
11	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 3714
# text = We have applied flow cytometry to the investigation of interferon-gamma activation of human monocytes.
1	We	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
2	have	have	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
3	applied	apply	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
4	flow	flow	ADJ	JJ	Degree=Pos	_	_	_	_
5	cytometry	cytometry	NOUN	NN	Number=Sing	_	_	_	_
6	to	to	ADP	IN	_	_	_	_	_
7	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
8	investigation	investigation	NOUN	NN	Number=Sing	_	_	_	_
9	of	of	ADP	IN	_	_	_	_	_
10	interferon	interferon	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
11	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
12	gamma	gamma	NOUN	NN	Number=Sing	_	_	_	_
13	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
14	of	of	ADP	IN	_	_	_	_	_
15	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
16	monocytes	monocyte	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
17	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3715
# text = This approach uses monoclonal antibodies that distinguish between the native and phosphorylated forms of STAT-1.
1	This	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
2	approach	approach	NOUN	NN	Number=Sing	_	_	_	_
3	uses	use	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
4	monoclonal	monoclonal	ADJ	JJ	Degree=Pos	_	_	_	_
5	antibodies	antibody	NOUN	NNS	Number=Plur	_	_	_	_
6	that	that	PRON	WDT	PronType=Rel	_	_	_	_
7	distinguish	distinguish	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
8	between	between	ADP	IN	_	_	_	_	_
9	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
10	native	native	NOUN	NN	Number=Sing	_	_	_	_
11	and	and	CCONJ	CC	_	_	_	_	_
12	phosphorylated	phosphorylate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
13	forms	form	NOUN	NNS	Number=Plur	_	_	_	_
14	of	of	ADP	IN	_	_	_	_	_
15	STAT	STAT	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
16	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
17	1	1	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
18	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3716
# text = It enables rapid and quantitative assessment of STAT-1 phosphorylation on a discrete cell basis and is both more sensitive and less time consuming than immunoblotting.
1	It	it	PRON	PRP	Case=Nom|Gender=Neut|Number=Sing|Person=3|PronType=Prs	_	_	_	_
2	enables	enable	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
3	rapid	rapid	ADJ	JJ	Degree=Pos	_	_	_	_
4	and	and	CCONJ	CC	_	_	_	_	_
5	quantitative	quantitative	ADJ	JJ	Degree=Pos	_	_	_	_
6	assessment	assessment	NOUN	NN	Number=Sing	_	_	_	_
7	of	of	ADP	IN	_	_	_	_	_
8	STAT	STAT	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
9	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
10	1	1	NUM	CD	NumType=Card	_	_	_	_
11	phosphorylation	phosphorylation	NOUN	NN	Number=Sing	_	_	_	_
12	on	on	ADP	IN	_	_	_	_	_
13	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
14	discrete	discrete	NOUN	NN	Number=Sing	_	_	_	_
15	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
16	basis	basis	NOUN	NN	Number=Sing	_	_	_	_
17	and	and	CCONJ	CC	_	_	_	_	_
18	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
19	both	both	ADV	RB	_	_	_	_	_
20	more	more	ADV	RBR	_	_	_	_	_
21	sensitive	sensitive	ADJ	JJ	Degree=Pos	_	_	_	_
22	and	and	CCONJ	CC	_	_	_	_	_
23	less	less	ADJ	JJR	Degree=Cmp	_	_	_	_
24	time	time	NOUN	NN	Number=Sing	_	_	_	_
25	consuming	consume	VERB	VBG	VerbForm=Ger	_	_	_	_
26	than	than	SCONJ	IN	_	_	_	_	_
27	immunoblotting	immunoblott	VERB	VBG	VerbForm=Ger	_	_	_	SpaceAfter=No
28	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3717
# text = Furthermore, it allows for discrimination between a mixture of cells that differ in their response to interferon-gamma.
1	Furthermore	furthermore	ADV	RB	_	_	_	_	SpaceAfter=No
2	,	,	PUNCT	,	_	_	_	_	_
3	it	it	PRON	PRP	Case=Nom|Gender=Neut|Number=Sing|Person=3|PronType=Prs	_	_	_	_
4	allows	allow	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
5	for	for	ADP	IN	_	_	_	_	_
6	discrimination	discrimination	NOUN	NN	Number=Sing	_	_	_	_
7	between	between	ADP	IN	_	_	_	_	_
8	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
9	mixture	mixture	NOUN	NN	Number=Sing	_	_	_	_
10	of	of	ADP	IN	_	_	_	_	_
11	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
12	that	that	PRON	WDT	PronType=Rel	_	_	_	_
13	differ	differ	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
14	in	in	ADP	IN	_	_	_	_	_
15	their	they	PRON	PRP$	Number=Plur|Person=3|Poss=Yes|PronType=Prs	_	_	_	_
16	response	response	NOUN	NN	Number=Sing	_	_	_	_
17	to	to	ADP	IN	_	_	_	_	_
18	interferon	interferon	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
19	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
20	gamma	gamma	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
21	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3718
# text = This approach should allow for the evaluation of different intracellular signaling pathways using a combination of monoclonal reagents that are specific for native and activation modified proteins.
1	This	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
2	approach	approach	NOUN	NN	Number=Sing	_	_	_	_
3	should	should	AUX	MD	VerbForm=Fin	_	_	_	_
4	allow	allow	VERB	VB	VerbForm=Inf	_	_	_	_
5	for	for	ADP	IN	_	_	_	_	_
6	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
7	evaluation	evaluation	NOUN	NN	Number=Sing	_	_	_	_
8	of	of	ADP	IN	_	_	_	_	_
9	different	different	ADJ	JJ	Degree=Pos	_	_	_	_
10	intracellular	intracellular	ADJ	JJ	Degree=Pos	_	_	_	_
11	signaling	signaling	NOUN	NN	Number=Sing	_	_	_	_
12	pathways	pathway	NOUN	NNS	Number=Plur	_	_	_	_
13	using	use	VERB	VBG	VerbForm=Ger	_	_	_	_
14	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
15	combination	combination	NOUN	NN	Number=Sing	_	_	_	_
16	of	of	ADP	IN	_	_	_	_	_
17	monoclonal	monoclonal	ADJ	JJ	Degree=Pos	_	_	_	_
18	reagents	reagent	NOUN	NNS	Number=Plur	_	_	_	_
19	that	that	PRON	WDT	PronType=Rel	_	_	_	_
20	are	be	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
21	specific	specific	ADJ	JJ	Degree=Pos	_	_	_	_
22	for	for	ADP	IN	_	_	_	_	_
23	native	native	NOUN	NN	Number=Sing	_	_	_	_
24	and	and	CCONJ	CC	_	_	_	_	_
25	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
26	modified	modify	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
27	proteins	protein	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
28	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3719
# text = Application of this form of testing should prove valuable in screening for signaling defects in selected patients with recurrent infections.
1	Application	application	NOUN	NN	Number=Sing	_	_	_	_
2	of	of	ADP	IN	_	_	_	_	_
3	this	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
4	form	form	NOUN	NN	Number=Sing	_	_	_	_
5	of	of	ADP	IN	_	_	_	_	_
6	testing	testing	NOUN	NN	Number=Sing	_	_	_	_
7	should	should	AUX	MD	VerbForm=Fin	_	_	_	_
8	prove	prove	VERB	VB	VerbForm=Inf	_	_	_	_
9	valuable	valuable	ADJ	JJ	Degree=Pos	_	_	_	_
10	in	in	SCONJ	IN	_	_	_	_	_
11	screening	screen	VERB	VBG	VerbForm=Ger	_	_	_	_
12	for	for	SCONJ	IN	_	_	_	_	_
13	signaling	signal	VERB	VBG	VerbForm=Ger	_	_	_	_
14	defects	defect	NOUN	NNS	Number=Plur	_	_	_	_
15	in	in	ADP	IN	_	_	_	_	_
16	selected	selected	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
17	patients	patient	NOUN	NNS	Number=Plur	_	_	_	_
18	with	with	ADP	IN	_	_	_	_	_
19	recurrent	recurrent	ADJ	JJ	Degree=Pos	_	_	_	_
20	infections	infection	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
21	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3720
# text = In addition, this technique should permit dissection of a full range of cellular signaling pathways at the protein level.
1	In	in	ADP	IN	_	_	_	_	_
2	addition	addition	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
3	,	,	PUNCT	,	_	_	_	_	_
4	this	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
5	technique	technique	NOUN	NN	Number=Sing	_	_	_	_
6	should	should	AUX	MD	VerbForm=Fin	_	_	_	_
7	permit	permit	VERB	VB	VerbForm=Inf	_	_	_	_
8	dissection	dissection	NOUN	NN	Number=Sing	_	_	_	_
9	of	of	ADP	IN	_	_	_	_	_
10	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
11	full	full	ADJ	JJ	Degree=Pos	_	_	_	_
12	range	range	NOUN	NN	Number=Sing	_	_	_	_
13	of	of	ADP	IN	_	_	_	_	_
14	cellular	cellular	ADJ	JJ	Degree=Pos	_	_	_	_
15	signaling	signaling	NOUN	NN	Number=Sing	_	_	_	_
16	pathways	pathway	NOUN	NNS	Number=Plur	_	_	_	_
17	at	at	ADP	IN	_	_	_	_	_
18	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
19	protein	protein	NOUN	NN	Number=Sing	_	_	_	_
20	level	level	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
21	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 3721
# text = Document 003003552 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	003003552	003003552	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 3722
# text = Two glucocorticoid binding sites on the human glucocorticoid receptor.
1	Two	two	NUM	CD	NumType=Card	_	_	_	_
2	glucocorticoid	glucocorticoid	NOUN	NN	Number=Sing	_	_	_	_
3	binding	bind	VERB	VBG	VerbForm=Ger	_	_	_	_
4	sites	site	NOUN	NNS	Number=Plur	_	_	_	_
5	on	on	ADP	IN	_	_	_	_	_
6	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
7	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
8	glucocorticoid	glucocorticoid	NOUN	NN	Number=Sing	_	_	_	_
9	receptor	receptor	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
10	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 3723
# text = Glucocorticoids are known to have a lytic effect in leukemic cells via interactions with the glucocorticoid receptor (GR).
1	Glucocorticoids	Glucocorticoid	NOUN	NNS	Number=Plur	_	_	_	_
2	are	be	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
3	known	know	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
4	to	to	PART	TO	_	_	_	_	_
5	have	have	VERB	VB	VerbForm=Inf	_	_	_	_
6	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
7	lytic	lytic	ADJ	JJ	Degree=Pos	_	_	_	_
8	effect	effect	NOUN	NN	Number=Sing	_	_	_	_
9	in	in	ADP	IN	_	_	_	_	_
10	leukemic	leukemic	ADJ	JJ	Degree=Pos	_	_	_	_
11	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
12	via	via	ADP	IN	_	_	_	_	_
13	interactions	interaction	NOUN	NNS	Number=Plur	_	_	_	_
14	with	with	ADP	IN	_	_	_	_	_
15	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
16	glucocorticoid	glucocorticoid	ADJ	JJ	Degree=Pos	_	_	_	_
17	receptor	receptor	NOUN	NN	Number=Sing	_	_	_	_
18	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
19	GR	GR	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
20	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
21	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3724
# text = Cortisol and various synthetic glucocorticoids bind to the GR with one-site kinetics.
1	Cortisol	Cortisol	PROPN	NNP	Number=Sing	_	_	_	_
2	and	and	CCONJ	CC	_	_	_	_	_
3	various	various	ADJ	JJ	Degree=Pos	_	_	_	_
4	synthetic	synthetic	ADJ	JJ	Degree=Pos	_	_	_	_
5	glucocorticoids	glucocorticoid	NOUN	NNS	Number=Plur	_	_	_	_
6	bind	bind	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
7	to	to	ADP	IN	_	_	_	_	_
8	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
9	GR	Gr	NOUN	NN	Number=Sing	_	_	_	_
10	with	with	ADP	IN	_	_	_	_	_
11	one	one	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
12	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
13	site	site	NOUN	NN	Number=Sing	_	_	_	_
14	kinetics	kinetic	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
15	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3725
# text = Cortivazol (CVZ) is a unique, high potency synthetic glucocorticoid, which has a phenylpyrazol fused to the A-ring of the steroid nucleus and displays binding consistent with two or more sites in the cytosol from CEM C7 cells (a human acute lymphoblastic T-cell line).
1	Cortivazol	Cortivazol	PROPN	NNP	Number=Sing	_	_	_	_
2	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
3	CVZ	CVZ	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
4	)	)	PUNCT	-RRB-	_	_	_	_	_
5	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
6	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
7	unique	unique	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
8	,	,	PUNCT	,	_	_	_	_	_
9	high	high	ADJ	JJ	Degree=Pos	_	_	_	_
10	potency	potency	NOUN	NN	Number=Sing	_	_	_	_
11	synthetic	synthetic	ADJ	JJ	Degree=Pos	_	_	_	_
12	glucocorticoid	glucocorticoid	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
13	,	,	PUNCT	,	_	_	_	_	_
14	which	which	PRON	WDT	PronType=Rel	_	_	_	_
15	has	have	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
16	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
17	phenylpyrazol	phenylpyrazol	NOUN	NN	Number=Sing	_	_	_	_
18	fused	fused	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
19	to	to	ADP	IN	_	_	_	_	_
20	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
21	A	a	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
22	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
23	ring	ring	NOUN	NN	Number=Sing	_	_	_	_
24	of	of	ADP	IN	_	_	_	_	_
25	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
26	steroid	steroid	ADJ	JJ	Degree=Pos	_	_	_	_
27	nucleus	nucleus	NOUN	NN	Number=Sing	_	_	_	_
28	and	and	CCONJ	CC	_	_	_	_	_
29	displays	display	NOUN	NNS	Number=Plur	_	_	_	_
30	binding	bind	VERB	VBG	VerbForm=Ger	_	_	_	_
31	consistent	consistent	ADJ	JJ	Degree=Pos	_	_	_	_
32	with	with	ADP	IN	_	_	_	_	_
33	two	two	NUM	CD	NumType=Card	_	_	_	_
34	or	or	CCONJ	CC	_	_	_	_	_
35	more	more	ADJ	JJR	Degree=Cmp	_	_	_	_
36	sites	site	NOUN	NNS	Number=Plur	_	_	_	_
37	in	in	ADP	IN	_	_	_	_	_
38	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
39	cytosol	cytosol	NOUN	NN	Number=Sing	_	_	_	_
40	from	from	ADP	IN	_	_	_	_	_
41	CEM	CEM	PROPN	NNP	Number=Sing	_	_	_	_
42	C7	C7	NUM	CD	NumType=Card	_	_	_	_
43	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
44	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
45	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
46	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
47	acute	acute	NOUN	NN	Number=Sing	_	_	_	_
48	lymphoblastic	lymphoblastic	ADJ	JJ	Degree=Pos	_	_	_	_
49	T-	t-	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
50	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
51	line	line	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
52	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
53	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3726
# text = It has previously been shown that the lower affinity class of sites are similar in affinity and site molarity to those recognized by dexamethasone.
1	It	it	PRON	PRP	Case=Nom|Gender=Neut|Number=Sing|Person=3|PronType=Prs	_	_	_	_
2	has	have	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
3	previously	previously	ADV	RB	_	_	_	_	_
4	been	be	AUX	VBN	Tense=Past|VerbForm=Part	_	_	_	_
5	shown	show	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
6	that	that	SCONJ	IN	_	_	_	_	_
7	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
8	lower	lower	ADJ	JJR	Degree=Cmp	_	_	_	_
9	affinity	affinity	NOUN	NN	Number=Sing	_	_	_	_
10	class	class	NOUN	NN	Number=Sing	_	_	_	_
11	of	of	ADP	IN	_	_	_	_	_
12	sites	site	NOUN	NNS	Number=Plur	_	_	_	_
13	are	be	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
14	similar	similar	ADJ	JJ	Degree=Pos	_	_	_	_
15	in	in	ADP	IN	_	_	_	_	_
16	affinity	affinity	NOUN	NN	Number=Sing	_	_	_	_
17	and	and	CCONJ	CC	_	_	_	_	_
18	site	site	NOUN	NN	Number=Sing	_	_	_	_
19	molarity	molarity	NOUN	NN	Number=Sing	_	_	_	_
20	to	to	ADP	IN	_	_	_	_	_
21	those	those	PRON	DT	Number=Plur|PronType=Dem	_	_	_	_
22	recognized	recognize	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
23	by	by	ADP	IN	_	_	_	_	_
24	dexamethasone	dexamethasone	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
25	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3727
# text = The higher affinity sites bind CVZ with 20- to 50-fold greater affinity, consistent with CVZ's enhanced biological effects.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	higher	higher	ADJ	JJR	Degree=Cmp	_	_	_	_
3	affinity	affinity	NOUN	NN	Number=Sing	_	_	_	_
4	sites	site	NOUN	NNS	Number=Plur	_	_	_	_
5	bind	bind	ADP	IN	_	_	_	_	_
6	CVZ	CVZ	PROPN	NNP	Number=Sing	_	_	_	_
7	with	with	ADP	IN	_	_	_	_	_
8	20	20	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
9	-	-	PUNCT	:	_	_	_	_	_
10	to	to	ADP	IN	_	_	_	_	_
11	50	50	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
12	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
13	fold	fold	VERB	VB	Mood=Imp|VerbForm=Fin	_	_	_	_
14	greater	greater	ADJ	JJR	Degree=Cmp	_	_	_	_
15	affinity	affinity	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
16	,	,	PUNCT	,	_	_	_	_	_
17	consistent	consistent	VERB	VB	Mood=Imp|VerbForm=Fin	_	_	_	_
18	with	with	ADP	IN	_	_	_	_	_
19	CVZ	CVZ	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
20	's	's	PART	POS	_	_	_	_	_
21	enhanced	enhance	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
22	biological	biological	ADJ	JJ	Degree=Pos	_	_	_	_
23	effects	effect	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
24	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3728
# text = In mutant leukemic cells resistant to the lytic effects of dexamethasone, CVZ both lyses the cells and recognizes a single class of sites similar to the high affinity site in CEM C7 cells.
1	In	in	ADP	IN	_	_	_	_	_
2	mutant	mutant	ADJ	JJ	Degree=Pos	_	_	_	_
3	leukemic	leukemic	ADJ	JJ	Degree=Pos	_	_	_	_
4	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
5	resistant	resistant	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
6	to	to	ADP	IN	_	_	_	_	_
7	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
8	lytic	lytic	ADJ	JJ	Degree=Pos	_	_	_	_
9	effects	effect	NOUN	NNS	Number=Plur	_	_	_	_
10	of	of	ADP	IN	_	_	_	_	_
11	dexamethasone	dexamethasone	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
12	,	,	PUNCT	,	_	_	_	_	_
13	CVZ	CVZ	PROPN	NNP	Number=Sing	_	_	_	_
14	both	both	CCONJ	CC	_	_	_	_	_
15	lyses	lysis	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
16	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
17	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
18	and	and	CCONJ	CC	_	_	_	_	_
19	recognizes	recognize	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
20	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
21	single	single	ADJ	JJ	Degree=Pos	_	_	_	_
22	class	class	NOUN	NN	Number=Sing	_	_	_	_
23	of	of	ADP	IN	_	_	_	_	_
24	sites	site	NOUN	NNS	Number=Plur	_	_	_	_
25	similar	similar	ADJ	JJ	Degree=Pos	_	_	_	_
26	to	to	ADP	IN	_	_	_	_	_
27	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
28	high	high	ADJ	JJ	Degree=Pos	_	_	_	_
29	affinity	affinity	NOUN	NN	Number=Sing	_	_	_	_
30	site	site	NOUN	NN	Number=Sing	_	_	_	_
31	in	in	ADP	IN	_	_	_	_	_
32	CEM	CEM	PROPN	NNP	Number=Sing	_	_	_	_
33	C7	C7	NUM	CD	NumType=Card	_	_	_	_
34	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
35	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3729
# text = We have carried out experiments to define the nature of the higher affinity CVZ binding site.
1	We	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
2	have	have	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
3	carried	carry	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
4	out	out	ADP	RP	_	_	_	_	_
5	experiments	experiment	NOUN	NNS	Number=Plur	_	_	_	_
6	to	to	PART	TO	_	_	_	_	_
7	define	define	VERB	VB	VerbForm=Inf	_	_	_	_
8	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
9	nature	nature	NOUN	NN	Number=Sing	_	_	_	_
10	of	of	ADP	IN	_	_	_	_	_
11	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
12	higher	higher	ADJ	JJR	Degree=Cmp	_	_	_	_
13	affinity	affinity	NOUN	NN	Number=Sing	_	_	_	_
14	CVZ	CVZ	SCONJ	IN	Abbr=Yes	_	_	_	_
15	binding	bind	VERB	VBG	VerbForm=Ger	_	_	_	_
16	site	site	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
17	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3730
# text = We now show that: 1) CVZ has more than one binding site in a second, independent, B-cell line, IM-9; 2) the antiglucocorticoid RU 38486 is able to block both CVZ's higher and lower affinity sites; 3) all of CVZ's binding sites are on a protein immunologically indistinguishable from the human GR; and 4) freshly isolated clones of CVZ-resistant cells have lost all binding sites for CVZ.
1	We	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
2	now	now	ADV	RB	_	_	_	_	_
3	show	show	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
4	that	that	SCONJ	IN	_	_	_	_	SpaceAfter=No
5	:	:	PUNCT	:	_	_	_	_	_
6	1	1	X	LS	_	_	_	_	SpaceAfter=No
7	)	)	PUNCT	-RRB-	_	_	_	_	_
8	CVZ	Cvz	NOUN	NN	Number=Sing	_	_	_	_
9	has	have	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
10	more	more	ADJ	JJR	Degree=Cmp	_	_	_	_
11	than	than	ADP	IN	_	_	_	_	_
12	one	one	NUM	CD	NumType=Card	_	_	_	_
13	binding	bind	VERB	VBG	VerbForm=Ger	_	_	_	_
14	site	site	NOUN	NN	Number=Sing	_	_	_	_
15	in	in	ADP	IN	_	_	_	_	_
16	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
17	second	second	ADJ	JJ	Degree=Pos|NumType=Ord	_	_	_	SpaceAfter=No
18	,	,	PUNCT	,	_	_	_	_	_
19	independent	independent	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
20	,	,	PUNCT	,	_	_	_	_	_
21	B	b	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
22	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
23	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
24	line	line	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
25	,	,	PUNCT	,	_	_	_	_	_
26	IM	Im	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
27	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
28	9	9	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
29	;	;	PUNCT	,	_	_	_	_	_
30	2	2	X	LS	_	_	_	_	SpaceAfter=No
31	)	)	PUNCT	-RRB-	_	_	_	_	_
32	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
33	antiglucocorticoid	antiglucocorticoid	ADJ	JJ	Degree=Pos	_	_	_	_
34	RU	RU	PROPN	NNP	Number=Sing	_	_	_	_
35	38486	38486	NUM	CD	NumType=Card	_	_	_	_
36	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
37	able	able	ADJ	JJ	Degree=Pos	_	_	_	_
38	to	to	PART	TO	_	_	_	_	_
39	block	block	VERB	VB	VerbForm=Inf	_	_	_	_
40	both	both	CCONJ	CC	_	_	_	_	_
41	CVZ	Cvz	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
42	's	's	PART	POS	_	_	_	_	_
43	higher	higher	ADJ	JJR	Degree=Cmp	_	_	_	_
44	and	and	CCONJ	CC	_	_	_	_	_
45	lower	lower	ADJ	JJR	Degree=Cmp	_	_	_	_
46	affinity	affinity	NOUN	NN	Number=Sing	_	_	_	_
47	sites	site	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
48	;	;	PUNCT	,	_	_	_	_	_
49	3	3	X	LS	_	_	_	_	SpaceAfter=No
50	)	)	PUNCT	-RRB-	_	_	_	_	_
51	all	all	DET	DT	_	_	_	_	_
52	of	of	ADP	IN	_	_	_	_	_
53	CVZ	CVZ	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
54	's	's	PART	POS	_	_	_	_	_
55	binding	binding	NOUN	NN	Number=Sing	_	_	_	_
56	sites	site	NOUN	NNS	Number=Plur	_	_	_	_
57	are	be	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
58	on	on	ADP	IN	_	_	_	_	_
59	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
60	protein	protein	NOUN	NN	Number=Sing	_	_	_	_
61	immunologically	immunologically	ADV	RB	_	_	_	_	_
62	indistinguishable	indistinguishable	ADJ	JJ	Degree=Pos	_	_	_	_
63	from	from	ADP	IN	_	_	_	_	_
64	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
65	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
66	GR	Gr	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
67	;	;	PUNCT	,	_	_	_	_	_
68	and	and	CCONJ	CC	_	_	_	_	_
69	4	4	X	LS	_	_	_	_	SpaceAfter=No
70	)	)	PUNCT	-RRB-	_	_	_	_	_
71	freshly	freshly	ADV	RB	_	_	_	_	_
72	isolated	isolate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
73	clones	clone	NOUN	NNS	Number=Plur	_	_	_	_
74	of	of	ADP	IN	_	_	_	_	_
75	CVZ	CVZ	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
76	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
77	resistant	resistant	ADJ	JJ	Degree=Pos	_	_	_	_
78	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
79	have	have	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
80	lost	lose	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
81	all	all	DET	PDT	_	_	_	_	_
82	binding	binding	VERB	VBG	VerbForm=Ger	_	_	_	_
83	sites	site	NOUN	NNS	Number=Plur	_	_	_	_
84	for	for	ADP	IN	_	_	_	_	_
85	CVZ	CVZ	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
86	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3731
# text = These data indicate that CVZ is recognizing two glucocorticoid binding sites on the human GR or a protein very similar to it.
1	These	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
2	data	data	NOUN	NN	Number=Sing	_	_	_	_
3	indicate	indicate	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
4	that	that	SCONJ	IN	_	_	_	_	_
5	CVZ	CVZ	PROPN	NNP	Number=Sing	_	_	_	_
6	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
7	recognizing	recognize	VERB	VBG	Tense=Pres|VerbForm=Part	_	_	_	_
8	two	two	NUM	CD	NumType=Card	_	_	_	_
9	glucocorticoid	glucocorticoid	NOUN	NN	Number=Sing	_	_	_	_
10	binding	bind	VERB	VBG	VerbForm=Ger	_	_	_	_
11	sites	site	NOUN	NNS	Number=Plur	_	_	_	_
12	on	on	ADP	IN	_	_	_	_	_
13	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
14	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
15	GR	Gr	NOUN	NN	Number=Sing	_	_	_	_
16	or	or	CCONJ	CC	_	_	_	_	_
17	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
18	protein	protein	NOUN	NN	Number=Sing	_	_	_	_
19	very	very	ADV	RB	_	_	_	_	_
20	similar	similar	ADJ	JJ	Degree=Pos	_	_	_	_
21	to	to	ADP	IN	_	_	_	_	_
22	it	it	PRON	PRP	Case=Acc|Gender=Neut|Number=Sing|Person=3|PronType=Prs	_	_	_	SpaceAfter=No
23	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 3732
# text = Document 003003553 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	003003553	003003553	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 3733
# text = Transcriptional activation of the macrophage colony-stimulating factor gene by IL-2 is associated with secretion of bioactive macrophage colony-stimulating factor protein by monocytes and involves activation of the transcription factor NF-kappa B. Human peripheral blood monocytes (Mo) constitutively display the beta-chain of the receptor for IL-2, whereas expression of the IL-2R alpha-chain is not constitutive but inducible with IL-2.
1	Transcriptional	Transcriptional	ADJ	JJ	Degree=Pos	_	_	_	_
2	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
3	of	of	ADP	IN	_	_	_	_	_
4	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
5	macrophage	macrophage	NOUN	NN	Number=Sing	_	_	_	_
6	colony	colony	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
7	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
8	stimulating	stimulating	VERB	VBG	VerbForm=Ger	_	_	_	_
9	factor	factor	NOUN	NN	Number=Sing	_	_	_	_
10	gene	gene	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
11	by	by	ADP	IN	_	_	_	_	_
12	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
13	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
14	2	2	NUM	CD	NumType=Card	_	_	_	_
15	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
16	associated	associate	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
17	with	with	ADP	IN	_	_	_	_	_
18	secretion	secretion	NOUN	NN	Number=Sing	_	_	_	_
19	of	of	ADP	IN	_	_	_	_	_
20	bioactive	bioactive	ADJ	JJ	Degree=Pos	_	_	_	_
21	macrophage	macrophage	NOUN	NN	Number=Sing	_	_	_	_
22	colony	colony	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
23	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
24	stimulating	stimulate	VERB	VBG	VerbForm=Ger	_	_	_	_
25	factor	factor	NOUN	NN	Number=Sing	_	_	_	_
26	protein	protein	NOUN	NN	Number=Sing	_	_	_	_
27	by	by	ADP	IN	_	_	_	_	_
28	monocytes	monocyte	NOUN	NNS	Number=Plur	_	_	_	_
29	and	and	CCONJ	CC	_	_	_	_	_
30	involves	involve	NOUN	NNS	Number=Plur	_	_	_	_
31	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
32	of	of	ADP	IN	_	_	_	_	_
33	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
34	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
35	factor	factor	NOUN	NN	Number=Sing	_	_	_	_
36	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
37	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
38	kappa	kappa	PROPN	NNP	Number=Sing	_	_	_	_
39	B.	B.	PROPN	NNP	Number=Sing	_	_	_	SpacesAfter=\s\n
40	Human	Human	PROPN	NNP	Number=Sing	_	_	_	_
41	peripheral	peripheral	ADJ	JJ	Degree=Pos	_	_	_	_
42	blood	blood	NOUN	NN	Number=Sing	_	_	_	_
43	monocytes	monocyte	NOUN	NNS	Number=Plur	_	_	_	_
44	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
45	Mo	mo	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
46	)	)	PUNCT	-RRB-	_	_	_	_	_
47	constitutively	constitutively	ADV	RB	_	_	_	_	_
48	display	display	VERB	VB	Mood=Imp|VerbForm=Fin	_	_	_	_
49	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
50	beta	beta	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
51	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
52	chain	chain	NOUN	NN	Number=Sing	_	_	_	_
53	of	of	ADP	IN	_	_	_	_	_
54	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
55	receptor	receptor	NOUN	NN	Number=Sing	_	_	_	_
56	for	for	ADP	IN	_	_	_	_	_
57	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
58	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
59	2	2	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
60	,	,	PUNCT	,	_	_	_	_	_
61	whereas	whereas	SCONJ	IN	_	_	_	_	_
62	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
63	of	of	ADP	IN	_	_	_	_	_
64	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
65	IL	Il	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
66	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
67	2R	2r	PROPN	NNP	Number=Sing	_	_	_	_
68	alpha	alpha	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
69	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
70	chain	chain	NOUN	NN	Number=Sing	_	_	_	_
71	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
72	not	not	PART	RB	_	_	_	_	_
73	constitutive	constitutive	ADJ	JJ	Degree=Pos	_	_	_	_
74	but	but	CCONJ	CC	_	_	_	_	_
75	inducible	inducible	ADJ	JJ	Degree=Pos	_	_	_	_
76	with	with	ADP	IN	_	_	_	_	_
77	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
78	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
79	2	2	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
80	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3734
# text = Here we report that binding of human IL-2 to its binding site leads to transcriptional activation of the macrophage CSF (M-CSF) gene in Mo resulting in accumulation of M-CSF mRNA and subsequent release of bioactive M-CSF protein as demonstrated by ELISA and inhibition of IL-2 induced release of an activity-stimulating growth of monocyte-type colonies by a neutralizing anti-M-CSF antibody.
1	Here	here	ADV	RB	PronType=Dem	_	_	_	_
2	we	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
3	report	report	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
4	that	that	SCONJ	IN	_	_	_	_	_
5	binding	bind	VERB	VBG	VerbForm=Ger	_	_	_	_
6	of	of	ADP	IN	_	_	_	_	_
7	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
8	IL	IL	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
9	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
10	2	2	NUM	CD	NumType=Card	_	_	_	_
11	to	to	ADP	IN	_	_	_	_	_
12	its	its	PRON	PRP$	Gender=Neut|Number=Sing|Person=3|Poss=Yes|PronType=Prs	_	_	_	_
13	binding	binding	VERB	VBG	VerbForm=Ger	_	_	_	_
14	site	site	NOUN	NN	Number=Sing	_	_	_	_
15	leads	lead	NOUN	NNS	Number=Plur	_	_	_	_
16	to	to	ADP	IN	_	_	_	_	_
17	transcriptional	transcriptional	ADJ	JJ	Degree=Pos	_	_	_	_
18	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
19	of	of	ADP	IN	_	_	_	_	_
20	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
21	macrophage	macrophage	NOUN	NN	Number=Sing	_	_	_	_
22	CSF	CSF	NOUN	NN	Number=Sing	_	_	_	_
23	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
24	M	m	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
25	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
26	CSF	CSF	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
27	)	)	PUNCT	-RRB-	_	_	_	_	_
28	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
29	in	in	ADP	IN	_	_	_	_	_
30	Mo	mo	PROPN	NNP	Number=Sing	_	_	_	_
31	resulting	result	VERB	VBG	VerbForm=Ger	_	_	_	_
32	in	in	ADP	IN	_	_	_	_	_
33	accumulation	accumulation	NOUN	NN	Number=Sing	_	_	_	_
34	of	of	ADP	IN	_	_	_	_	_
35	M	m	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
36	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
37	CSF	CSF	PROPN	NNP	Number=Sing	_	_	_	_
38	mRNA	mRNA	PROPN	NNP	Number=Sing	_	_	_	_
39	and	and	CCONJ	CC	_	_	_	_	_
40	subsequent	subsequent	ADJ	JJ	Degree=Pos	_	_	_	_
41	release	release	NOUN	NN	Number=Sing	_	_	_	_
42	of	of	ADP	IN	_	_	_	_	_
43	bioactive	bioactive	ADJ	JJ	Degree=Pos	_	_	_	_
44	M	m	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
45	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
46	CSF	CSF	NOUN	NN	Number=Sing	_	_	_	_
47	protein	protein	NOUN	NN	Number=Sing	_	_	_	_
48	as	as	SCONJ	IN	_	_	_	_	_
49	demonstrated	demonstrate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
50	by	by	ADP	IN	_	_	_	_	_
51	ELISA	ELISA	PROPN	NNP	Number=Sing	_	_	_	_
52	and	and	CCONJ	CC	_	_	_	_	_
53	inhibition	inhibition	NOUN	NN	Number=Sing	_	_	_	_
54	of	of	ADP	IN	_	_	_	_	_
55	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
56	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
57	2	2	NUM	CD	NumType=Card	_	_	_	_
58	induced	induce	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
59	release	release	NOUN	NN	Number=Sing	_	_	_	_
60	of	of	ADP	IN	_	_	_	_	_
61	an	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
62	activity	activity	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
63	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
64	stimulating	stimulating	VERB	VBG	VerbForm=Ger	_	_	_	_
65	growth	growth	NOUN	NN	Number=Sing	_	_	_	_
66	of	of	ADP	IN	_	_	_	_	_
67	monocyte	monocyte	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
68	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
69	type	type	NOUN	NN	Number=Sing	_	_	_	_
70	colonies	colony	NOUN	NNS	Number=Plur	_	_	_	_
71	by	by	ADP	IN	_	_	_	_	_
72	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
73	neutralizing	neutralizing	VERB	VBG	VerbForm=Ger	_	_	_	_
74	anti-M	anti-M	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
75	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
76	CSF	CSF	NOUN	NN	Number=Sing	_	_	_	_
77	antibody	antibody	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
78	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3735
# text = Transcriptional activation of the M-CSF gene by IL-2 is preceded by enhanced binding activity of the transcription factor NF-kappa B to its recognition sequence in the 5' regulatory enhancer region of the M-CSF gene.
1	Transcriptional	Transcriptional	ADJ	JJ	Degree=Pos	_	_	_	_
2	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
3	of	of	ADP	IN	_	_	_	_	_
4	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
5	M	m	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
6	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
7	CSF	CSF	PROPN	NNP	Number=Sing	_	_	_	_
8	gene	gene	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
9	by	by	ADP	IN	_	_	_	_	_
10	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
11	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
12	2	2	NUM	CD	NumType=Card	_	_	_	_
13	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
14	preceded	preced	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
15	by	by	ADP	IN	_	_	_	_	_
16	enhanced	enhance	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
17	binding	bind	VERB	VBG	VerbForm=Ger	_	_	_	_
18	activity	activity	NOUN	NN	Number=Sing	_	_	_	_
19	of	of	ADP	IN	_	_	_	_	_
20	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
21	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
22	factor	factor	NOUN	NN	Number=Sing	_	_	_	_
23	NF	Nf	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
24	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
25	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_
26	B	b	NOUN	NN	Number=Sing	_	_	_	_
27	to	to	ADP	IN	_	_	_	_	_
28	its	its	PRON	PRP$	Gender=Neut|Number=Sing|Person=3|Poss=Yes|PronType=Prs	_	_	_	_
29	recognition	recognition	NOUN	NN	Number=Sing	_	_	_	_
30	sequence	sequence	NOUN	NN	Number=Sing	_	_	_	_
31	in	in	ADP	IN	_	_	_	_	_
32	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
33	5	5	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
34	'	's	PUNCT	``	_	_	_	_	_
35	regulatory	regulatory	ADJ	JJ	Degree=Pos	_	_	_	_
36	enhancer	enhancer	NOUN	NN	Number=Sing	_	_	_	_
37	region	region	NOUN	NN	Number=Sing	_	_	_	_
38	of	of	ADP	IN	_	_	_	_	_
39	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
40	M	m	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
41	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
42	CSF	Csf	NOUN	NN	Number=Sing	_	_	_	_
43	gene	gene	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
44	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3736
# text = Moreover, using a heterologous promoter (herpes thymidine kinase) construct containing the NF-kappa B consensus sequence, it is shown that NF-kappa B binding by an IL-2-induced monocyte-derived nuclear protein confers reporter gene (human growth hormone) activity.
1	Moreover	moreover	ADV	RB	_	_	_	_	SpaceAfter=No
2	,	,	PUNCT	,	_	_	_	_	_
3	using	use	VERB	VBG	VerbForm=Ger	_	_	_	_
4	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
5	heterologous	heterologous	ADJ	JJ	Degree=Pos	_	_	_	_
6	promoter	promoter	NOUN	NN	Number=Sing	_	_	_	_
7	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
8	herpes	herpes	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
9	thymidine	thymidine	PRON	PRP	_	_	_	_	_
10	kinase	kinase	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
11	)	)	PUNCT	-RRB-	_	_	_	_	_
12	construct	construct	NOUN	NN	Number=Sing	_	_	_	_
13	containing	contain	VERB	VBG	VerbForm=Ger	_	_	_	_
14	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
15	NF	NF	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
16	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
17	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_
18	B	b	NOUN	NN	Number=Sing	_	_	_	_
19	consensus	consensus	NOUN	NN	Number=Sing	_	_	_	_
20	sequence	sequence	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
21	,	,	PUNCT	,	_	_	_	_	_
22	it	it	PRON	PRP	Case=Nom|Gender=Neut|Number=Sing|Person=3|PronType=Prs	_	_	_	_
23	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
24	shown	show	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
25	that	that	SCONJ	IN	_	_	_	_	_
26	NF	Nf	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
27	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
28	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_
29	B	b	NOUN	NN	Number=Sing	_	_	_	_
30	binding	bind	VERB	VBG	VerbForm=Ger	_	_	_	_
31	by	by	ADP	IN	_	_	_	_	_
32	an	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
33	IL	Il	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
34	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
35	2	2	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
36	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
37	induced	induce	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
38	monocyte	monocyte	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
39	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
40	derived	derive	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
41	nuclear	nuclear	ADJ	JJ	Degree=Pos	_	_	_	_
42	protein	protein	NOUN	NN	Number=Sing	_	_	_	_
43	confers	confer	NOUN	NNS	Number=Plur	_	_	_	_
44	reporter	reporter	NOUN	NN	Number=Sing	_	_	_	_
45	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
46	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
47	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
48	growth	growth	NOUN	NN	Number=Sing	_	_	_	_
49	hormone	hormone	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
50	)	)	PUNCT	-RRB-	_	_	_	_	_
51	activity	activity	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
52	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3737
# text = Taken together, our findings indicate that IL-2 induces gene expression of M-CSF in human blood-derived Mo and provide evidence for involvement of NF-kappa B in transcriptional regulation of this gene.
1	Taken	take	PROPN	NNP	Number=Sing	_	_	_	_
2	together	together	ADV	RB	_	_	_	_	SpaceAfter=No
3	,	,	PUNCT	,	_	_	_	_	_
4	our	we	PRON	PRP$	Number=Plur|Person=1|Poss=Yes|PronType=Prs	_	_	_	_
5	findings	finding	NOUN	NNS	Number=Plur	_	_	_	_
6	indicate	indicate	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
7	that	that	SCONJ	IN	_	_	_	_	_
8	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
9	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
10	2	2	NUM	CD	NumType=Card	_	_	_	_
11	induces	induces	NOUN	NNS	Number=Plur	_	_	_	_
12	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
13	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
14	of	of	ADP	IN	_	_	_	_	_
15	M-	m-	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
16	CSF	Csf	NOUN	NN	Number=Sing	_	_	_	_
17	in	in	ADP	IN	_	_	_	_	_
18	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
19	blood	blood	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
20	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
21	derived	derive	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
22	Mo	mo	PROPN	NNP	Number=Sing	_	_	_	_
23	and	and	CCONJ	CC	_	_	_	_	_
24	provide	provide	VERB	VB	VerbForm=Inf	_	_	_	_
25	evidence	evidence	NOUN	NN	Number=Sing	_	_	_	_
26	for	for	ADP	IN	_	_	_	_	_
27	involvement	involvement	NOUN	NN	Number=Sing	_	_	_	_
28	of	of	ADP	IN	_	_	_	_	_
29	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
30	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
31	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	_
32	B	b	NOUN	NN	Number=Sing	_	_	_	_
33	in	in	ADP	IN	_	_	_	_	_
34	transcriptional	transcriptional	ADJ	JJ	Degree=Pos	_	_	_	_
35	regulation	regulation	NOUN	NN	Number=Sing	_	_	_	_
36	of	of	ADP	IN	_	_	_	_	_
37	this	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
38	gene	gene	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
39	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 3738
# text = Document 003003557 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	003003557	003003557	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 3739
# text = Human T-cell leukemia virus type 1 Tax protein induces the expression of STAT1 and STAT5 genes in T-cells.
1	Human	human	ADJ	JJ	Degree=Pos	_	_	_	_
2	T-	t-	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
3	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
4	leukemia	leukemia	NOUN	NN	Number=Sing	_	_	_	_
5	virus	virus	NOUN	NN	Number=Sing	_	_	_	_
6	type	type	NOUN	NN	Number=Sing	_	_	_	_
7	1	1	NUM	CD	NumType=Card	_	_	_	_
8	Tax	tax	NOUN	NN	Number=Sing	_	_	_	_
9	protein	protein	NOUN	NN	Number=Sing	_	_	_	_
10	induces	induce	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
11	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
12	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
13	of	of	ADP	IN	_	_	_	_	_
14	STAT1	STAT1	NUM	CD	NumType=Card	_	_	_	_
15	and	and	CCONJ	CC	_	_	_	_	_
16	STAT5	STAT5	NUM	CD	NumType=Card	_	_	_	_
17	genes	gene	NOUN	NNS	Number=Plur	_	_	_	_
18	in	in	ADP	IN	_	_	_	_	_
19	T-	t-	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
20	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
21	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 3740
# text = Human T-cell leukemia virus type 1 (HTLV-1) Tax transforms normal T-cells in the presence of interleukin (IL)-2 in vitro.
1	Human	human	ADJ	JJ	Degree=Pos	_	_	_	_
2	T-	t-	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
3	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
4	leukemia	leukemia	NOUN	NN	Number=Sing	_	_	_	_
5	virus	virus	NOUN	NN	Number=Sing	_	_	_	_
6	type	type	NOUN	NN	Number=Sing	_	_	_	_
7	1	1	NUM	CD	NumType=Card	_	_	_	_
8	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
9	HTLV	HTLV	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
10	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
11	1	1	X	LS	_	_	_	_	SpaceAfter=No
12	)	)	PUNCT	-RRB-	_	_	_	_	_
13	Tax	tax	NOUN	NN	Number=Sing	_	_	_	_
14	transforms	transform	NOUN	NNS	Number=Plur	_	_	_	_
15	normal	normal	ADJ	JJ	Degree=Pos	_	_	_	_
16	T-	t-	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
17	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
18	in	in	ADP	IN	_	_	_	_	_
19	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
20	presence	presence	NOUN	NN	Number=Sing	_	_	_	_
21	of	of	ADP	IN	_	_	_	_	_
22	interleukin	interleukin	NOUN	NN	Number=Sing	_	_	_	_
23	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
24	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
25	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
26	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
27	2	2	NUM	CD	NumType=Card	_	_	_	_
28	in	in	ADP	IN	_	_	_	_	_
29	vitro	vitro	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
30	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3741
# text = STAT is a family of transcription factors that play a pivotal role in cytokine-induced functions of a various type of cells.
1	STAT	Stat	PRON	DT	Number=Sing|PronType=Dem	_	_	_	_
2	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
3	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
4	family	family	NOUN	NN	Number=Sing	_	_	_	_
5	of	of	ADP	IN	_	_	_	_	_
6	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
7	factors	factor	NOUN	NNS	Number=Plur	_	_	_	_
8	that	that	PRON	WDT	PronType=Rel	_	_	_	_
9	play	play	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
10	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
11	pivotal	pivotal	ADJ	JJ	Degree=Pos	_	_	_	_
12	role	role	NOUN	NN	Number=Sing	_	_	_	_
13	in	in	ADP	IN	_	_	_	_	_
14	cytokine	cytokine	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
15	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
16	induced	induce	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
17	functions	function	NOUN	NNS	Number=Plur	_	_	_	_
18	of	of	ADP	IN	_	_	_	_	_
19	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
20	various	various	ADJ	JJ	Degree=Pos	_	_	_	_
21	type	type	NOUN	NN	Number=Sing	_	_	_	_
22	of	of	ADP	IN	_	_	_	_	_
23	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
24	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3742
# text = We investigated the involvement of STATs in the transformation of T-cells by HTLV-1.
1	We	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
2	investigated	investigate	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
3	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
4	involvement	involvement	NOUN	NN	Number=Sing	_	_	_	_
5	of	of	ADP	IN	_	_	_	_	_
6	STATs	STATs	PROPN	NNPS	Number=Plur	_	_	_	_
7	in	in	ADP	IN	_	_	_	_	_
8	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
9	transformation	transformation	NOUN	NN	Number=Sing	_	_	_	_
10	of	of	ADP	IN	_	_	_	_	_
11	T-	T-	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
12	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
13	by	by	ADP	IN	_	_	_	_	_
14	HTLV	HTLV	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
15	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
16	1	1	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
17	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3743
# text = HTLV-1-transformed T-cell lines expressed higher amounts of STAT1, STAT3 and STAT5 RNA and proteins than virus-negative T cells.
1	HTLV	haHtlve	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
2	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
3	1	1	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
4	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
5	transformed	transform	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
6	T-	t-	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
7	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
8	lines	line	NOUN	NNS	Number=Plur	_	_	_	_
9	expressed	express	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
10	higher	higher	ADJ	JJR	Degree=Cmp	_	_	_	_
11	amounts	amount	NOUN	NNS	Number=Plur	_	_	_	_
12	of	of	ADP	IN	_	_	_	_	_
13	STAT1	stat1	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
14	,	,	PUNCT	,	_	_	_	_	_
15	STAT3	STAT3	NUM	CD	NumType=Card	_	_	_	_
16	and	and	CCONJ	CC	_	_	_	_	_
17	STAT5	STAT5	PROPN	NNP	Number=Sing	_	_	_	_
18	RNA	RNA	PROPN	NNP	Number=Sing	_	_	_	_
19	and	and	CCONJ	CC	_	_	_	_	_
20	proteins	protein	NOUN	NNS	Number=Plur	_	_	_	_
21	than	than	ADP	IN	_	_	_	_	_
22	virus	virus	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
23	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
24	negative	negative	ADJ	JJ	Degree=Pos	_	_	_	_
25	T	t	PROPN	NNP	Number=Sing	_	_	_	_
26	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
27	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3744
# text = The expression of STAT1 and STAT5 in a human T-cell line was induced by Tax.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
3	of	of	ADP	IN	_	_	_	_	_
4	STAT1	stat1	NUM	CD	NumType=Card	_	_	_	_
5	and	and	CCONJ	CC	_	_	_	_	_
6	STAT5	stat5	NUM	CD	NumType=Card	_	_	_	_
7	in	in	ADP	IN	_	_	_	_	_
8	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
9	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
10	T-	t-	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
11	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
12	line	line	NOUN	NN	Number=Sing	_	_	_	_
13	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
14	induced	induce	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
15	by	by	ADP	IN	_	_	_	_	_
16	Tax	tax	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
17	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3745
# text = IL-2 induced the DNA binding activity of STAT3 and STAT5 of a HTLV-1-transformed cell line and then stimulated its proliferation.
1	IL	Il	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
2	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
3	2	2	NUM	CD	NumType=Card	_	_	_	_
4	induced	induce	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
5	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
6	DNA	dna	NOUN	NN	Number=Sing	_	_	_	_
7	binding	binde	VERB	VBG	VerbForm=Ger	_	_	_	_
8	activity	activity	NOUN	NN	Number=Sing	_	_	_	_
9	of	of	ADP	IN	_	_	_	_	_
10	STAT3	STAT3	NUM	CD	NumType=Card	_	_	_	_
11	and	and	CCONJ	CC	_	_	_	_	_
12	STAT5	STAT5	NUM	CD	NumType=Card	_	_	_	_
13	of	of	ADP	IN	_	_	_	_	_
14	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
15	HTLV	HTLV	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
16	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
17	1	1	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
18	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
19	transformed	transform	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
20	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
21	line	line	NOUN	NN	Number=Sing	_	_	_	_
22	and	and	CCONJ	CC	_	_	_	_	_
23	then	then	ADV	RB	PronType=Dem	_	_	_	_
24	stimulated	stimulate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
25	its	its	PRON	PRP$	Gender=Neut|Number=Sing|Person=3|Poss=Yes|PronType=Prs	_	_	_	_
26	proliferation	proliferation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
27	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3746
# text = In contrast, IL-2 did neither in a cell line lacking STAT3 and STAT5.
1	In	in	ADP	IN	_	_	_	_	_
2	contrast	contrast	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
3	,	,	PUNCT	,	_	_	_	_	_
4	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
5	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
6	2	2	NUM	CD	NumType=Card	_	_	_	_
7	did	do	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
8	neither	neither	VERB	VB	VerbForm=Inf	_	_	_	_
9	in	in	ADP	IN	_	_	_	_	_
10	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
11	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
12	line	line	NOUN	NN	Number=Sing	_	_	_	_
13	lacking	lack	VERB	VBG	VerbForm=Ger	_	_	_	_
14	STAT3	STAT3	NUM	CD	NumType=Card	_	_	_	_
15	and	and	CCONJ	CC	_	_	_	_	_
16	STAT5	stat5	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
17	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3747
# text = The expression of STAT1, STAT3 and STAT5 mRNAs were also induced by a T-cell mitogen in normal human peripheral blood mononuclear cells.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
3	of	of	ADP	IN	_	_	_	_	_
4	STAT1	stat1	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
5	,	,	PUNCT	,	_	_	_	_	_
6	STAT3	STAT3	NUM	CD	NumType=Card	_	_	_	_
7	and	and	CCONJ	CC	_	_	_	_	_
8	STAT5	STAT5	NUM	CD	NumType=Card	_	_	_	_
9	mRNAs	mRNA	NOUN	NNS	Number=Plur	_	_	_	_
10	were	be	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
11	also	also	ADV	RB	_	_	_	_	_
12	induced	induce	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
13	by	by	ADP	IN	_	_	_	_	_
14	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
15	T-	t-	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
16	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
17	mitogen	mitogen	NOUN	NNS	Number=Plur	_	_	_	_
18	in	in	ADP	IN	_	_	_	_	_
19	normal	normal	ADJ	JJ	Degree=Pos	_	_	_	_
20	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
21	peripheral	peripheral	ADJ	JJ	Degree=Pos	_	_	_	_
22	blood	blood	NOUN	NN	Number=Sing	_	_	_	_
23	mononuclear	mononuclear	ADJ	JJ	Degree=Pos	_	_	_	_
24	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
25	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3748
# text = Our results suggest that the induction of STAT1 and STAT5 by Tax enhances cytokine-induced functions of virus-infected T-cells, hence the induction may play a role in IL-2-dependent transformation steps of T-cells by HTLV-1.
1	Our	we	PRON	PRP$	Number=Plur|Person=1|Poss=Yes|PronType=Prs	_	_	_	_
2	results	result	NOUN	NNS	Number=Plur	_	_	_	_
3	suggest	suggest	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
4	that	that	SCONJ	IN	_	_	_	_	_
5	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
6	induction	induction	NOUN	NN	Number=Sing	_	_	_	_
7	of	of	ADP	IN	_	_	_	_	_
8	STAT1	stat1	NUM	CD	NumType=Card	_	_	_	_
9	and	and	CCONJ	CC	_	_	_	_	_
10	STAT5	stat5	NUM	CD	NumType=Card	_	_	_	_
11	by	by	ADP	IN	_	_	_	_	_
12	Tax	tax	NOUN	NN	Number=Sing	_	_	_	_
13	enhances	enhance	NOUN	NNS	Number=Plur	_	_	_	_
14	cytokine	cytokine	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
15	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
16	induced	induce	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
17	functions	function	NOUN	NNS	Number=Plur	_	_	_	_
18	of	of	ADP	IN	_	_	_	_	_
19	virus-infected	virus-infected	ADJ	JJ	Degree=Pos	_	_	_	_
20	T-	t-	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
21	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
22	,	,	PUNCT	,	_	_	_	_	_
23	hence	hence	ADV	RB	_	_	_	_	_
24	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
25	induction	induction	NOUN	NN	Number=Sing	_	_	_	_
26	may	may	AUX	MD	VerbForm=Fin	_	_	_	_
27	play	play	VERB	VB	VerbForm=Inf	_	_	_	_
28	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
29	role	role	NOUN	NN	Number=Sing	_	_	_	_
30	in	in	ADP	IN	_	_	_	_	_
31	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
32	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
33	2	2	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
34	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
35	dependent	dependent	ADJ	JJ	Degree=Pos	_	_	_	_
36	transformation	transformation	NOUN	NN	Number=Sing	_	_	_	_
37	steps	step	NOUN	NNS	Number=Plur	_	_	_	_
38	of	of	ADP	IN	_	_	_	_	_
39	T-	T-	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
40	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
41	by	by	ADP	IN	_	_	_	_	_
42	HTLV	HTLV	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
43	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
44	1	1	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
45	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 3749
# text = Document 003003559 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	003003559	003003559	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 3750
# text = A microtitre assay system for glucocorticoid receptors:
1	A	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
2	microtitre	microtitre	ADJ	JJ	Degree=Pos	_	_	_	_
3	assay	assay	NOUN	NN	Number=Sing	_	_	_	_
4	system	system	NOUN	NN	Number=Sing	_	_	_	_
5	for	for	ADP	IN	_	_	_	_	_
6	glucocorticoid	glucocorticoid	ADJ	JJ	Degree=Pos	_	_	_	_
7	receptors	receptor	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
8	:	:	PUNCT	:	_	_	_	_	_

# sent_id = 3751
# text = decreased receptor concentration in myocardial infarction.
1	decreased	decrease	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
2	receptor	receptor	NOUN	NN	Number=Sing	_	_	_	_
3	concentration	concentration	NOUN	NN	Number=Sing	_	_	_	_
4	in	in	ADP	IN	_	_	_	_	_
5	myocardial	myocardial	ADJ	JJ	Degree=Pos	_	_	_	_
6	infarction	infarction	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
7	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 3752
# text = A major difficulty in determination of glucocorticoid receptor sites is the very complicated assay procedure.
1	A	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
2	major	major	ADJ	JJ	Degree=Pos	_	_	_	_
3	difficulty	difficulty	NOUN	NN	Number=Sing	_	_	_	_
4	in	in	ADP	IN	_	_	_	_	_
5	determination	determination	NOUN	NN	Number=Sing	_	_	_	_
6	of	of	ADP	IN	_	_	_	_	_
7	glucocorticoid	glucocorticoid	ADJ	JJ	Degree=Pos	_	_	_	_
8	receptor	receptor	NOUN	NN	Number=Sing	_	_	_	_
9	sites	site	NOUN	NNS	Number=Plur	_	_	_	_
10	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
11	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
12	very	very	ADJ	JJ	Degree=Pos	_	_	_	_
13	complicated	complicated	ADJ	JJ	Degree=Pos	_	_	_	_
14	assay	assay	NOUN	NN	Number=Sing	_	_	_	_
15	procedure	procedure	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
16	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3753
# text = Therefore, we describe a microtitre assay system for glucocorticoid receptors which is a whole-cell competitive binding radioassay using [3H]-dexamethasone as radioligand.
1	Therefore	therefore	ADV	RB	_	_	_	_	SpaceAfter=No
2	,	,	PUNCT	,	_	_	_	_	_
3	we	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
4	describe	describe	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
5	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
6	microtitre	microtitre	NOUN	NN	Number=Sing	_	_	_	_
7	assay	assay	NOUN	NN	Number=Sing	_	_	_	_
8	system	system	NOUN	NN	Number=Sing	_	_	_	_
9	for	for	ADP	IN	_	_	_	_	_
10	glucocorticoid	glucocorticoid	ADJ	JJ	Degree=Pos	_	_	_	_
11	receptors	receptor	NOUN	NNS	Number=Plur	_	_	_	_
12	which	which	PRON	WDT	PronType=Rel	_	_	_	_
13	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
14	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
15	whole	whole	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
16	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
17	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
18	competitive	competitive	ADJ	JJ	Degree=Pos	_	_	_	_
19	binding	bind	VERB	VBG	VerbForm=Ger	_	_	_	_
20	radioassay	radioassay	NOUN	NN	Number=Sing	_	_	_	_
21	using	use	VERB	VBG	VerbForm=Ger	_	_	_	_
22	[	[	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
23	3	3	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
24	H	h	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
25	]	]	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
26	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
27	dexamethasone	dexamethasone	NOUN	NN	Number=Sing	_	_	_	_
28	as	as	ADP	IN	_	_	_	_	_
29	radioligand	radioligand	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
30	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3754
# text = This modification of a previously described protocol simplifies and reduces laboratory work and allows assay reproducibility to be controlled more reliably.
1	This	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
2	modification	modification	NOUN	NN	Number=Sing	_	_	_	_
3	of	of	ADP	IN	_	_	_	_	_
4	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
5	previously	previously	ADV	RB	_	_	_	_	_
6	described	describe	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
7	protocol	protocol	NOUN	NN	Number=Sing	_	_	_	_
8	simplifies	simplify	NOUN	NNS	Number=Plur	_	_	_	_
9	and	and	CCONJ	CC	_	_	_	_	_
10	reduces	reduce	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
11	laboratory	laboratory	ADJ	JJ	Degree=Pos	_	_	_	_
12	work	work	NOUN	NN	Number=Sing	_	_	_	_
13	and	and	CCONJ	CC	_	_	_	_	_
14	allows	allow	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
15	assay	assay	ADJ	JJ	Degree=Pos	_	_	_	_
16	reproducibility	reproducibility	NOUN	NN	Number=Sing	_	_	_	_
17	to	to	PART	TO	_	_	_	_	_
18	be	be	AUX	VB	VerbForm=Inf	_	_	_	_
19	controlled	controll	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
20	more	more	ADV	RBR	_	_	_	_	_
21	reliably	reliably	ADV	RB	_	_	_	_	SpaceAfter=No
22	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3755
# text = Thus enabled to perform the test on multiple blood samples in parallel, we investigated cardiac infarction patients over a 12-day period to test if glucocorticoid receptor binding is altered in this 'stressful' disease.
1	Thus	thus	ADV	RB	_	_	_	_	_
2	enabled	enable	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
3	to	to	PART	TO	_	_	_	_	_
4	perform	perform	VERB	VB	VerbForm=Inf	_	_	_	_
5	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
6	test	test	NOUN	NN	Number=Sing	_	_	_	_
7	on	on	ADP	IN	_	_	_	_	_
8	multiple	multiple	ADJ	JJ	Degree=Pos	_	_	_	_
9	blood	blood	NOUN	NN	Number=Sing	_	_	_	_
10	samples	sample	NOUN	NNS	Number=Plur	_	_	_	_
11	in	in	ADP	IN	_	_	_	_	_
12	parallel	parallel	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
13	,	,	PUNCT	,	_	_	_	_	_
14	we	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
15	investigated	investigate	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
16	cardiac	cardiac	ADJ	JJ	Degree=Pos	_	_	_	_
17	infarction	infarction	NOUN	NN	Number=Sing	_	_	_	_
18	patients	patient	NOUN	NN	Number=Sing	_	_	_	_
19	over	over	ADP	IN	_	_	_	_	_
20	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
21	12	12	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
22	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
23	day	day	NOUN	NN	Number=Sing	_	_	_	_
24	period	period	NOUN	NN	Number=Sing	_	_	_	_
25	to	to	PART	TO	_	_	_	_	_
26	test	test	VERB	VB	VerbForm=Inf	_	_	_	_
27	if	if	SCONJ	IN	_	_	_	_	_
28	glucocorticoid	glucocorticoid	NOUN	NN	Number=Sing	_	_	_	_
29	receptor	receptor	NOUN	NN	Number=Sing	_	_	_	_
30	binding	binding	VERB	VBG	VerbForm=Ger	_	_	_	_
31	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
32	altered	alter	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
33	in	in	ADP	IN	_	_	_	_	_
34	this	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
35	'	'	PUNCT	``	_	_	_	_	SpaceAfter=No
36	stressful	stressful	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
37	'	'	PUNCT	''	_	_	_	_	_
38	disease	disease	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
39	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3756
# text = On the first day of the disease, glucocorticoid receptor capacity was significantly decreased without alteration of the receptor-ligand affinity, whereas on days 4 and 12 the number of receptor sites was normal again.
1	On	on	ADP	IN	_	_	_	_	_
2	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
3	first	first	ADJ	JJ	Degree=Pos|NumType=Ord	_	_	_	_
4	day	day	NOUN	NN	Number=Sing	_	_	_	_
5	of	of	ADP	IN	_	_	_	_	_
6	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
7	disease	disease	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
8	,	,	PUNCT	,	_	_	_	_	_
9	glucocorticoid	glucocorticoid	ADJ	JJ	Degree=Pos	_	_	_	_
10	receptor	receptor	NOUN	NN	Number=Sing	_	_	_	_
11	capacity	capacity	NOUN	NN	Number=Sing	_	_	_	_
12	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
13	significantly	significantly	ADV	RB	_	_	_	_	_
14	decreased	decrease	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
15	without	without	ADP	IN	_	_	_	_	_
16	alteration	alteration	NOUN	NN	Number=Sing	_	_	_	_
17	of	of	ADP	IN	_	_	_	_	_
18	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
19	receptor	receptor	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
20	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
21	ligand	ligand	NOUN	NN	Number=Sing	_	_	_	_
22	affinity	affinity	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
23	,	,	PUNCT	,	_	_	_	_	_
24	whereas	whereas	SCONJ	IN	_	_	_	_	_
25	on	on	ADP	IN	_	_	_	_	_
26	days	day	NOUN	NNS	Number=Plur	_	_	_	_
27	4	4	NUM	CD	NumType=Card	_	_	_	_
28	and	and	CCONJ	CC	_	_	_	_	_
29	12	12	NUM	CD	NumType=Card	_	_	_	_
30	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
31	number	number	NOUN	NN	Number=Sing	_	_	_	_
32	of	of	ADP	IN	_	_	_	_	_
33	receptor	receptor	NOUN	NN	Number=Sing	_	_	_	_
34	sites	site	NOUN	NNS	Number=Plur	_	_	_	_
35	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
36	normal	normal	ADJ	JJ	Degree=Pos	_	_	_	_
37	again	again	ADV	RB	_	_	_	_	SpaceAfter=No
38	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3757
# text = This result fits well into the general observation of stress-induced down-regulation of immune responses.
1	This	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
2	result	result	NOUN	NN	Number=Sing	_	_	_	_
3	fits	fit	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
4	well	well	ADV	RB	Degree=Pos	_	_	_	_
5	into	into	ADP	IN	_	_	_	_	_
6	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
7	general	general	ADJ	JJ	Degree=Pos	_	_	_	_
8	observation	observation	NOUN	NN	Number=Sing	_	_	_	_
9	of	of	ADP	IN	_	_	_	_	_
10	stress	stress	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
11	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
12	induced	induce	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
13	down	down	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
14	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
15	regulation	regulation	NOUN	NN	Number=Sing	_	_	_	_
16	of	of	ADP	IN	_	_	_	_	_
17	immune	immune	ADJ	JJ	Degree=Pos	_	_	_	_
18	responses	response	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
19	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 3758
# text = Document 003003563 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	003003563	003003563	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 3759
# text = The suppression of T cell function and NF(kappa)B expression by serine protease inhibitors is blocked by N-acetylcysteine.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	suppression	suppression	NOUN	NN	Number=Sing	_	_	_	_
3	of	of	ADP	IN	_	_	_	_	_
4	T	t	PROPN	NNP	Number=Sing	_	_	_	_
5	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
6	function	function	NOUN	NN	Number=Sing	_	_	_	_
7	and	and	CCONJ	CC	_	_	_	_	_
8	NF	Nf	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
9	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
10	kappa	kappa	X	FW	Foreign=Yes	_	_	_	SpaceAfter=No
11	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
12	B	b	ADJ	JJ	Degree=Pos	_	_	_	_
13	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
14	by	by	ADP	IN	_	_	_	_	_
15	serine	serine	NOUN	NN	Number=Sing	_	_	_	_
16	protease	protease	NOUN	NN	Number=Sing	_	_	_	_
17	inhibitors	inhibitor	NOUN	NNS	Number=Plur	_	_	_	_
18	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
19	blocked	block	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
20	by	by	ADP	IN	_	_	_	_	_
21	N-	n-	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
22	acetylcysteine	acetylcysteine	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
23	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 3760
# text = Direct evidence that N-acetylcysteine (NAC) enhances the immune response of peripheral blood T cells at the level of NF(kappa)B is presented.
1	Direct	direct	ADJ	JJ	Degree=Pos	_	_	_	_
2	evidence	evidence	NOUN	NN	Number=Sing	_	_	_	_
3	that	that	PRON	WDT	PronType=Rel	_	_	_	_
4	N-	N-	SYM	NFP	_	_	_	_	SpaceAfter=No
5	acetylcysteine	acetylcysteine	NOUN	NN	Number=Sing	_	_	_	_
6	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
7	NAC	NAC	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
8	)	)	PUNCT	-RRB-	_	_	_	_	_
9	enhances	enhance	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
10	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
11	immune	immune	ADJ	JJ	Degree=Pos	_	_	_	_
12	response	response	NOUN	NN	Number=Sing	_	_	_	_
13	of	of	ADP	IN	_	_	_	_	_
14	peripheral	peripheral	ADJ	JJ	Degree=Pos	_	_	_	_
15	blood	blood	NOUN	NN	Number=Sing	_	_	_	_
16	T	t	PROPN	NNP	Number=Sing	_	_	_	_
17	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
18	at	at	ADP	IN	_	_	_	_	_
19	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
20	level	level	NOUN	NN	Number=Sing	_	_	_	_
21	of	of	ADP	IN	_	_	_	_	_
22	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
23	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
24	kappa	kappa	X	FW	Foreign=Yes	_	_	_	SpaceAfter=No
25	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
26	B	b	NOUN	NN	Number=Sing	_	_	_	_
27	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
28	presented	presented	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	SpaceAfter=No
29	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3761
# text = In addition, NAC blocks the suppression of T cell mitogenesis and cytokine production by protease inhibitors such as N-tosylphenylalanine chloromethyl ketone (TPCK).
1	In	in	ADP	IN	_	_	_	_	_
2	addition	addition	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
3	,	,	PUNCT	,	_	_	_	_	_
4	NAC	NAC	PROPN	NNP	Number=Sing	_	_	_	_
5	blocks	block	NOUN	NNS	Number=Plur	_	_	_	_
6	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
7	suppression	suppression	NOUN	NN	Number=Sing	_	_	_	_
8	of	of	ADP	IN	_	_	_	_	_
9	T	t	PROPN	NNP	Number=Sing	_	_	_	_
10	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
11	mitogenesis	mitogenesis	NOUN	NN	Number=Sing	_	_	_	_
12	and	and	CCONJ	CC	_	_	_	_	_
13	cytokine	cytokine	NOUN	NN	Number=Sing	_	_	_	_
14	production	production	NOUN	NN	Number=Sing	_	_	_	_
15	by	by	ADP	IN	_	_	_	_	_
16	protease	protease	NOUN	NN	Number=Sing	_	_	_	_
17	inhibitors	inhibitor	NOUN	NNS	Number=Plur	_	_	_	_
18	such	such	ADJ	JJ	Degree=Pos	_	_	_	_
19	as	as	ADP	IN	_	_	_	_	_
20	N	N	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
21	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
22	tosylphenylalanine	tosylphenylalanine	NUM	CD	NumType=Card	_	_	_	_
23	chloromethyl	chloromethyl	NOUN	NN	Number=Sing	_	_	_	_
24	ketone	ketone	NOUN	NN	Number=Sing	_	_	_	_
25	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
26	TPCK	TPCK	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
27	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
28	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3762
# text = The proliferative responses of purified CD4+ or CD8+ T cells are suppressed more strongly by TPCK when anti-CD28 rather than the phorbol ester PMA is used as the mitogenic coactivator.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	proliferative	proliferative	ADJ	JJ	Degree=Pos	_	_	_	_
3	responses	response	NOUN	NNS	Number=Plur	_	_	_	_
4	of	of	ADP	IN	_	_	_	_	_
5	purified	purified	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
6	CD4	CD4	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
7	+	+	SYM	SYM	_	_	_	_	_
8	or	or	CCONJ	CC	_	_	_	_	_
9	CD8	CD8	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
10	+	+	SYM	SYM	_	_	_	_	_
11	T	t	NUM	CD	NumType=Card	_	_	_	_
12	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
13	are	be	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
14	suppressed	suppress	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
15	more	more	ADV	RBR	_	_	_	_	_
16	strongly	strongly	ADV	RB	_	_	_	_	_
17	by	by	ADP	IN	_	_	_	_	_
18	TPCK	TPCK	NUM	CD	NumType=Card	_	_	_	_
19	when	when	ADV	WRB	PronType=Int	_	_	_	_
20	anti-CD28	anti-CD28	NUM	CD	NumType=Card	_	_	_	_
21	rather	rather	ADV	RB	_	_	_	_	_
22	than	than	ADP	IN	_	_	_	_	_
23	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
24	phorbol	phorbol	NOUN	NN	Number=Sing	_	_	_	_
25	ester	ester	NOUN	NN	Number=Sing	_	_	_	_
26	PMA	PMA	PROPN	NNP	Number=Sing	_	_	_	_
27	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
28	used	use	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
29	as	as	ADP	IN	_	_	_	_	_
30	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
31	mitogenic	mitogenic	ADJ	JJ	Degree=Pos	_	_	_	_
32	coactivator	coactivator	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
33	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3763
# text = Cytokine (IL-2, IL-6, INF-gamma) production is inhibited 95-100% by concentrations of TPCK that totally suppress the mitogenesis of CD4+ or CD8+ cells.
1	Cytokine	Cytokine	PROPN	NNP	Number=Sing	_	_	_	_
2	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
3	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
4	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
5	2	2	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
6	,	,	PUNCT	,	_	_	_	_	_
7	IL	IL	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
8	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
9	6	6	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
10	,	,	PUNCT	,	_	_	_	_	_
11	INF	Inf	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
12	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
13	gamma	gamma	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
14	)	)	PUNCT	-RRB-	_	_	_	_	_
15	production	production	NOUN	NN	Number=Sing	_	_	_	_
16	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
17	inhibited	inhibit	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
18	95	95	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
19	-	-	SYM	SYM	_	_	_	_	SpaceAfter=No
20	100	100	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
21	%	%	SYM	NN	Number=Sing	_	_	_	_
22	by	by	ADP	IN	_	_	_	_	_
23	concentrations	concentration	NOUN	NNS	Number=Plur	_	_	_	_
24	of	of	ADP	IN	_	_	_	_	_
25	TPCK	TPCK	NOUN	NN	Number=Sing	_	_	_	_
26	that	that	PRON	WDT	PronType=Rel	_	_	_	_
27	totally	totally	ADV	RB	_	_	_	_	_
28	suppress	suppress	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
29	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
30	mitogenesis	mitogenesis	NOUN	NN	Number=Sing	_	_	_	_
31	of	of	ADP	IN	_	_	_	_	_
32	CD4	CD4	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
33	+	+	SYM	SYM	_	_	_	_	_
34	or	or	CCONJ	CC	_	_	_	_	_
35	CD8	CD8	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
36	+	+	SYM	SYM	_	_	_	_	_
37	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
38	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3764
# text = Using electrophoretic mobility shift assays, we find that TPCK virtually abolishes (to less than 1%) the levels of NF(kappa)B (but not Oct-1) found in nuclear and whole cell extracts of activated T cells.
1	Using	use	VERB	VBG	VerbForm=Ger	_	_	_	_
2	electrophoretic	electrophoretic	ADJ	JJ	Degree=Pos	_	_	_	_
3	mobility	mobility	NOUN	NN	Number=Sing	_	_	_	_
4	shift	shift	NOUN	NN	Number=Sing	_	_	_	_
5	assays	assay	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	SpaceAfter=No
6	,	,	PUNCT	,	_	_	_	_	_
7	we	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
8	find	find	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
9	that	that	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
10	TPCK	Tpck	NOUN	NN	Number=Sing	_	_	_	_
11	virtually	virtually	ADV	RB	_	_	_	_	_
12	abolishes	abolish	ADV	RB	_	_	_	_	_
13	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
14	to	to	ADP	IN	_	_	_	_	_
15	less	less	ADJ	JJR	Degree=Cmp	_	_	_	_
16	than	than	ADP	IN	_	_	_	_	_
17	1	1	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
18	%	%	SYM	NN	Number=Sing	_	_	_	SpaceAfter=No
19	)	)	PUNCT	-RRB-	_	_	_	_	_
20	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
21	levels	level	NOUN	NNS	Number=Plur	_	_	_	_
22	of	of	ADP	IN	_	_	_	_	_
23	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
24	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
25	kappa	kappa	X	FW	Foreign=Yes	_	_	_	SpaceAfter=No
26	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
27	B	b	NOUN	NN	Number=Sing	_	_	_	_
28	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
29	but	but	CCONJ	CC	_	_	_	_	_
30	not	not	ADV	RB	_	_	_	_	_
31	Oct	Oct	ADV	RB	_	_	_	_	SpaceAfter=No
32	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
33	1	1	X	LS	_	_	_	_	SpaceAfter=No
34	)	)	PUNCT	-RRB-	_	_	_	_	_
35	found	find	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
36	in	in	ADP	IN	_	_	_	_	_
37	nuclear	nuclear	ADJ	JJ	Degree=Pos	_	_	_	_
38	and	and	CCONJ	CC	_	_	_	_	_
39	whole	whole	ADJ	JJ	Degree=Pos	_	_	_	_
40	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
41	extracts	extract	NOUN	NNS	Number=Plur	_	_	_	_
42	of	of	ADP	IN	_	_	_	_	_
43	activated	activated	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
44	T	T	PROPN	NNP	Number=Sing	_	_	_	_
45	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
46	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3765
# text = Strikingly, the immunosuppressive effects of TPCK are blocked when T cells are pretreated for 15 min with 5 mM NAC.
1	Strikingly	strikingly	ADV	RB	_	_	_	_	SpaceAfter=No
2	,	,	PUNCT	,	_	_	_	_	_
3	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
4	immunosuppressive	immunosuppressive	ADJ	JJ	Degree=Pos	_	_	_	_
5	effects	effect	NOUN	NNS	Number=Plur	_	_	_	_
6	of	of	ADP	IN	_	_	_	_	_
7	TPCK	Tpck	NOUN	NN	Number=Sing	_	_	_	_
8	are	be	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
9	blocked	block	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
10	when	when	ADV	WRB	PronType=Int	_	_	_	_
11	T	t	NUM	CD	NumType=Card	_	_	_	_
12	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
13	are	be	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
14	pretreated	pretreate	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
15	for	for	ADP	IN	_	_	_	_	_
16	15	15	NUM	CD	NumType=Card	_	_	_	_
17	min	min	NOUN	NNS	Number=Plur	_	_	_	_
18	with	with	ADP	IN	_	_	_	_	_
19	5	5	NUM	CD	NumType=Card	_	_	_	_
20	mM	mm	PROPN	NNP	Number=Sing	_	_	_	_
21	NAC	Nac	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
22	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3766
# text = NAC not only blocks the effect of TPCK but enhances mitogenesis and cytokine production (>2.5-fold in some cases) upon activation of unsuppressed T cells.
1	NAC	Nac	NOUN	NN	Number=Sing	_	_	_	_
2	not	not	ADV	RB	_	_	_	_	_
3	only	only	ADV	RB	_	_	_	_	_
4	blocks	block	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
5	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
6	effect	effect	NOUN	NN	Number=Sing	_	_	_	_
7	of	of	ADP	IN	_	_	_	_	_
8	TPCK	TPCK	NOUN	NN	Number=Sing	_	_	_	_
9	but	but	CCONJ	CC	_	_	_	_	_
10	enhances	enhance	NOUN	NNS	Number=Plur	_	_	_	_
11	mitogenesis	mitogenesis	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
12	and	and	CCONJ	CC	_	_	_	_	_
13	cytokine	cytokine	VERB	VB	VerbForm=Inf	_	_	_	_
14	production	production	NOUN	NN	Number=Sing	_	_	_	_
15	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
16	>	>	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
17	2.5	2.5	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
18	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
19	fold	fold	NOUN	NN	Number=Sing	_	_	_	_
20	in	in	ADP	IN	_	_	_	_	_
21	some	some	DET	DT	_	_	_	_	_
22	cases	case	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
23	)	)	PUNCT	-RRB-	_	_	_	_	_
24	upon	upon	ADP	IN	_	_	_	_	_
25	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
26	of	of	ADP	IN	_	_	_	_	_
27	unsuppressed	unsuppressed	ADJ	JJ	Degree=Pos	_	_	_	_
28	T	t	PROPN	NNP	Number=Sing	_	_	_	_
29	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
30	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3767
# text = Our data support the notion that NF(kappa)B and I(kappa)B proteases play obligate roles in T cell activation and mitogenesis, roles that are enhanced significantly by NAC.
1	Our	we	PRON	PRP$	Number=Plur|Person=1|Poss=Yes|PronType=Prs	_	_	_	_
2	data	data	NOUN	NN	Number=Sing	_	_	_	_
3	support	support	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
4	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
5	notion	notion	NOUN	NN	Number=Sing	_	_	_	_
6	that	that	PRON	WDT	PronType=Rel	_	_	_	_
7	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
8	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
9	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
10	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
11	B	b	NOUN	NN	Number=Sing	_	_	_	_
12	and	and	CCONJ	CC	_	_	_	_	_
13	I	I	PRON	PRP	Case=Nom|Number=Sing|Person=1|PronType=Prs	_	_	_	SpaceAfter=No
14	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
15	kappa	kappa	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
16	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
17	B	b	NOUN	NN	Number=Sing	_	_	_	_
18	proteases	protease	NOUN	NNS	Number=Plur	_	_	_	_
19	play	play	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
20	obligate	obligate	ADJ	JJ	Degree=Pos	_	_	_	_
21	roles	role	NOUN	NNS	Number=Plur	_	_	_	_
22	in	in	ADP	IN	_	_	_	_	_
23	T	t	PROPN	NNP	Number=Sing	_	_	_	_
24	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
25	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
26	and	and	CCONJ	CC	_	_	_	_	_
27	mitogenesis	mitogenesis	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
28	,	,	PUNCT	,	_	_	_	_	_
29	roles	role	NOUN	NNS	Number=Plur	_	_	_	_
30	that	that	PRON	WDT	PronType=Rel	_	_	_	_
31	are	be	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
32	enhanced	enhance	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
33	significantly	significantly	ADV	RB	_	_	_	_	_
34	by	by	ADP	IN	_	_	_	_	_
35	NAC	NAC	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
36	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 3768
# text = Document 003003571 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	003003571	003003571	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 3769
# text = Detection in non-erythroid cells of a factor with the binding characteristics of the erythroid cell transcription factor EF1.
1	Detection	detection	NOUN	NN	Number=Sing	_	_	_	_
2	in	in	ADP	IN	_	_	_	_	_
3	non-erythroid	non-erythroid	ADJ	JJ	Degree=Pos	_	_	_	_
4	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
5	of	of	ADP	IN	_	_	_	_	_
6	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
7	factor	factor	NOUN	NN	Number=Sing	_	_	_	_
8	with	with	ADP	IN	_	_	_	_	_
9	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
10	binding	binding	VERB	VBG	VerbForm=Ger	_	_	_	_
11	characteristics	characteristic	NOUN	NNS	Number=Plur	_	_	_	_
12	of	of	ADP	IN	_	_	_	_	_
13	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
14	erythroid	erythroid	ADJ	JJ	Degree=Pos	_	_	_	_
15	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
16	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
17	factor	factor	NOUN	NN	Number=Sing	_	_	_	_
18	EF1	Ef1	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
19	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 3770
# text = The erythroid transcription factor erythroid factor-1 (EF1) plays a critical role in the transcription of erythroid-specific genes.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	erythroid	erythroid	ADJ	JJ	Degree=Pos	_	_	_	_
3	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
4	factor	factor	NOUN	NN	Number=Sing	_	_	_	_
5	erythroid	erythroid	NOUN	NN	Number=Sing	_	_	_	_
6	factor	factor	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
7	-1	-1	NUM	CD	NumType=Card	_	_	_	_
8	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
9	EF1	Ef1	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
10	)	)	PUNCT	-RRB-	_	_	_	_	_
11	plays	play	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
12	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
13	critical	critical	ADJ	JJ	Degree=Pos	_	_	_	_
14	role	role	NOUN	NN	Number=Sing	_	_	_	_
15	in	in	ADP	IN	_	_	_	_	_
16	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
17	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
18	of	of	ADP	IN	_	_	_	_	_
19	erythroid	erythroid	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
20	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
21	specific	specific	ADJ	JJ	Degree=Pos	_	_	_	_
22	genes	gene	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
23	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3771
# text = Here we report the presence of a factor with the mobility and sequence-specific DNA-binding characteristics of EF1 at low abundance in a wide variety of non-erythroid cell types.
1	Here	here	ADV	RB	PronType=Dem	_	_	_	_
2	we	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
3	report	report	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
4	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
5	presence	presence	NOUN	NN	Number=Sing	_	_	_	_
6	of	of	ADP	IN	_	_	_	_	_
7	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
8	factor	factor	NOUN	NN	Number=Sing	_	_	_	_
9	with	with	ADP	IN	_	_	_	_	_
10	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
11	mobility	mobility	NOUN	NN	Number=Sing	_	_	_	_
12	and	and	CCONJ	CC	_	_	_	_	_
13	sequence	sequence	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
14	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
15	specific	specific	ADJ	JJ	Degree=Pos	_	_	_	_
16	DNA	dna	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
17	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
18	binding	bind	VERB	VBG	VerbForm=Ger	_	_	_	_
19	characteristics	characteristic	NOUN	NNS	Number=Plur	_	_	_	_
20	of	of	ADP	IN	_	_	_	_	_
21	EF1	Ef1	NOUN	NN	Number=Sing	_	_	_	_
22	at	at	ADP	IN	_	_	_	_	_
23	low	low	ADJ	JJ	Degree=Pos	_	_	_	_
24	abundance	abundance	NOUN	NN	Number=Sing	_	_	_	_
25	in	in	ADP	IN	_	_	_	_	_
26	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
27	wide	wide	ADJ	JJ	Degree=Pos	_	_	_	_
28	variety	variety	NOUN	NN	Number=Sing	_	_	_	_
29	of	of	ADP	IN	_	_	_	_	_
30	non-erythroid	non-erythroid	ADJ	JJ	Degree=Pos	_	_	_	_
31	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
32	types	type	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
33	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3772
# text = This is the first report of an EF1-like activity in non-erythroid cells and indicates that this factor may play a role in the regulation of genes expressed in such cells.
1	This	this	PRON	DT	Number=Sing|PronType=Dem	_	_	_	_
2	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
3	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
4	first	first	ADJ	JJ	Degree=Pos|NumType=Ord	_	_	_	_
5	report	report	NOUN	NN	Number=Sing	_	_	_	_
6	of	of	ADP	IN	_	_	_	_	_
7	an	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
8	EF	EF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
9	1	1	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
10	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
11	like	like	ADJ	JJ	Degree=Pos	_	_	_	_
12	activity	activity	NOUN	NN	Number=Sing	_	_	_	_
13	in	in	ADP	IN	_	_	_	_	_
14	non-erythroid	non-erythroid	ADJ	JJ	Degree=Pos	_	_	_	_
15	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
16	and	and	CCONJ	CC	_	_	_	_	_
17	indicates	indicate	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
18	that	that	SCONJ	IN	_	_	_	_	_
19	this	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
20	factor	factor	NOUN	NN	Number=Sing	_	_	_	_
21	may	may	AUX	MD	VerbForm=Fin	_	_	_	_
22	play	play	VERB	VB	VerbForm=Inf	_	_	_	_
23	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
24	role	role	NOUN	NN	Number=Sing	_	_	_	_
25	in	in	ADP	IN	_	_	_	_	_
26	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
27	regulation	regulation	NOUN	NN	Number=Sing	_	_	_	_
28	of	of	ADP	IN	_	_	_	_	_
29	genes	gene	NOUN	NNS	Number=Plur	_	_	_	_
30	expressed	express	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
31	in	in	ADP	IN	_	_	_	_	_
32	such	such	ADJ	JJ	Degree=Pos	_	_	_	_
33	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
34	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 3773
# text = Document 003003578 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	003003578	003003578	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 3774
# text = A newly established megakaryoblastic/erythroid cell line that differentiates to red cells in the presence of erythropoietin and produces platelet-like particles.
1	A	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
2	newly	newly	ADV	RB	_	_	_	_	_
3	established	establish	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
4	megakaryoblastic	megakaryoblastic	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
5	/	/	PUNCT	,	_	_	_	_	SpaceAfter=No
6	erythroid	erythroid	ADJ	JJ	Degree=Pos	_	_	_	_
7	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
8	line	line	NOUN	NN	Number=Sing	_	_	_	_
9	that	that	PRON	WDT	PronType=Rel	_	_	_	_
10	differentiates	differentiate	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
11	to	to	ADP	IN	_	_	_	_	_
12	red	red	ADJ	JJ	Degree=Pos	_	_	_	_
13	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
14	in	in	ADP	IN	_	_	_	_	_
15	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
16	presence	presence	NOUN	NN	Number=Sing	_	_	_	_
17	of	of	ADP	IN	_	_	_	_	_
18	erythropoietin	erythropoietin	NOUN	NN	Number=Sing	_	_	_	_
19	and	and	CCONJ	CC	_	_	_	_	_
20	produces	produce	NOUN	NNS	Number=Plur	_	_	_	_
21	platelet	platelet	ADV	RB	_	_	_	_	SpaceAfter=No
22	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
23	like	like	ADJ	JJ	Degree=Pos	_	_	_	_
24	particles	particle	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
25	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 3775
# text = In August, 1992, we established a leukemic cell line (NS-Meg) from a patient in megakaryoblastic transformation of Philadelphia chromosome-positive chronic myeloid leukemia.
1	In	in	ADP	IN	_	_	_	_	_
2	August	August	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
3	,	,	PUNCT	,	_	_	_	_	_
4	1992	1992	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
5	,	,	PUNCT	,	_	_	_	_	_
6	we	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
7	established	establish	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
8	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
9	leukemic	leukemic	ADJ	JJ	Degree=Pos	_	_	_	_
10	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
11	line	line	NOUN	NN	Number=Sing	_	_	_	_
12	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
13	NS	NS	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
14	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
15	Meg	Meg	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
16	)	)	PUNCT	-RRB-	_	_	_	_	_
17	from	from	ADP	IN	_	_	_	_	_
18	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
19	patient	patient	NOUN	NN	Number=Sing	_	_	_	_
20	in	in	ADP	IN	_	_	_	_	_
21	megakaryoblastic	megakaryoblastic	ADJ	JJ	Degree=Pos	_	_	_	_
22	transformation	transformation	NOUN	NN	Number=Sing	_	_	_	_
23	of	of	ADP	IN	_	_	_	_	_
24	Philadelphia	Philadelphia	PROPN	NNP	Number=Sing	_	_	_	_
25	chromosome	chromosome	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
26	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
27	positive	positive	ADJ	JJ	Degree=Pos	_	_	_	_
28	chronic	chronic	ADJ	JJ	Degree=Pos	_	_	_	_
29	myeloid	myeloid	NOUN	NN	Number=Sing	_	_	_	_
30	leukemia	leukemia	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
31	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3776
# text = The NS-Meg cells were positive for alpha-naphthyl acetate esterase and periodic acid-Schiff (PAS) staining and for surface CD4, CD7, CD13, CD34, CD41a, and glycophorin A antigens.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	NS	N	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
3	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
4	Meg	Meg	PROPN	NNP	Number=Sing	_	_	_	_
5	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
6	were	be	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
7	positive	positive	ADJ	JJ	Degree=Pos	_	_	_	_
8	for	for	ADP	IN	_	_	_	_	_
9	alpha	alpha	ADV	RB	_	_	_	_	SpaceAfter=No
10	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
11	naphthyl	naphthyl	ADJ	JJ	Degree=Pos	_	_	_	_
12	acetate	acetate	NOUN	NN	Number=Sing	_	_	_	_
13	esterase	esterase	NOUN	NN	Number=Sing	_	_	_	_
14	and	and	CCONJ	CC	_	_	_	_	_
15	periodic	periodic	ADJ	JJ	Degree=Pos	_	_	_	_
16	acid	acid	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
17	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
18	Schiff	Schiff	NOUN	NN	Number=Sing	_	_	_	_
19	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
20	PAS	PAS	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
21	)	)	PUNCT	-RRB-	_	_	_	_	_
22	staining	stai	VERB	VBG	VerbForm=Ger	_	_	_	_
23	and	and	CCONJ	CC	_	_	_	_	_
24	for	for	ADP	IN	_	_	_	_	_
25	surface	surface	NOUN	NN	Number=Sing	_	_	_	_
26	CD4	CD4	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
27	,	,	PUNCT	,	_	_	_	_	_
28	CD7	CD7	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
29	,	,	PUNCT	,	_	_	_	_	_
30	CD13	CD13	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
31	,	,	PUNCT	,	_	_	_	_	_
32	CD34	CD34	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
33	,	,	PUNCT	,	_	_	_	_	_
34	CD41a	CD41a	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
35	,	,	PUNCT	,	_	_	_	_	_
36	and	and	CCONJ	CC	_	_	_	_	_
37	glycophorin	glycophorin	VERB	VB	Mood=Imp|VerbForm=Fin	_	_	_	_
38	A	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
39	antigens	antigen	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
40	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3777
# text = Ultrastructurally, the cells had alpha-granules, demarcation membranes, and platelet peroxidase activity.
1	Ultrastructurally	Ultrastructurally	ADV	RB	_	_	_	_	SpaceAfter=No
2	,	,	PUNCT	,	_	_	_	_	_
3	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
4	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
5	had	have	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
6	alpha	alpha	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
7	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
8	granules	granule	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
9	,	,	PUNCT	,	_	_	_	_	_
10	demarcation	demarcation	NOUN	NN	Number=Sing	_	_	_	_
11	membranes	membrane	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
12	,	,	PUNCT	,	_	_	_	_	_
13	and	and	CCONJ	CC	_	_	_	_	_
14	platelet	platelet	NOUN	NN	Number=Sing	_	_	_	_
15	peroxidase	peroxidase	NOUN	NN	Number=Sing	_	_	_	_
16	activity	activity	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
17	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3778
# text = The NS-Meg cells spontaneously produced platelet-like particles which contained alpha-granules, mitochondria and dense bodies, strongly suggesting platelet production.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	NS	N	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
3	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
4	Meg	Meg	PROPN	NNP	Number=Sing	_	_	_	_
5	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
6	spontaneously	spontaneously	ADV	RB	_	_	_	_	_
7	produced	produce	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
8	platelet	platelet	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
9	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
10	like	like	ADJ	JJ	Degree=Pos	_	_	_	_
11	particles	particle	NOUN	NNS	Number=Plur	_	_	_	_
12	which	which	PRON	WDT	PronType=Rel	_	_	_	_
13	contained	contain	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
14	alpha	alpha	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
15	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
16	granules	granule	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
17	,	,	PUNCT	,	_	_	_	_	_
18	mitochondria	mitochondria	NOUN	NN	Number=Sing	_	_	_	_
19	and	and	CCONJ	CC	_	_	_	_	_
20	dense	dense	NOUN	NN	Number=Sing	_	_	_	_
21	bodies	bodie	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
22	,	,	PUNCT	,	_	_	_	_	_
23	strongly	strongly	ADV	RB	_	_	_	_	_
24	suggesting	suggest	VERB	VBG	VerbForm=Ger	_	_	_	_
25	platelet	platelet	NOUN	NN	Number=Sing	_	_	_	_
26	production	production	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
27	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3779
# text = Erythropoietin (Epo), granulocyte/macrophage colony stimulating factor(GM-CSF), and interleukin 3 (IL-3) promoted the growth of NS-Meg cells.
1	Erythropoietin	Erythropoietin	PROPN	NNP	Number=Sing	_	_	_	_
2	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
3	Epo	Epo	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
4	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
5	,	,	PUNCT	,	_	_	_	_	_
6	granulocyte	granulocyte	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
7	/	/	PUNCT	,	_	_	_	_	SpaceAfter=No
8	macrophage	macrophage	NOUN	NN	Number=Sing	_	_	_	_
9	colony	colony	NOUN	NN	Number=Sing	_	_	_	_
10	stimulating	stimulating	VERB	VBG	VerbForm=Ger	_	_	_	_
11	factor	factor	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
12	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
13	GM	GM	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
14	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
15	CSF	CSF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
16	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
17	,	,	PUNCT	,	_	_	_	_	_
18	and	and	CCONJ	CC	_	_	_	_	_
19	interleukin	interleukin	ADJ	JJ	Degree=Pos	_	_	_	_
20	3	3	NUM	CD	NumType=Card	_	_	_	_
21	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
22	IL	Il	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
23	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
24	3	3	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
25	)	)	PUNCT	-RRB-	_	_	_	_	_
26	promoted	promote	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
27	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
28	growth	growth	NOUN	NN	Number=Sing	_	_	_	_
29	of	of	ADP	IN	_	_	_	_	_
30	NS	NS	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
31	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
32	Meg	Meg	PROPN	NNP	Number=Sing	_	_	_	_
33	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
34	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3780
# text = Phorbol-12-myristate-13-acetate increased the expression of both CD41a and CD61 antigens.
1	Phorbol	Phorbol	INTJ	UH	_	_	_	_	SpaceAfter=No
2	-12-myristate	-12-myristate	VERB	VB	Mood=Imp|VerbForm=Fin	_	_	_	SpaceAfter=No
3	-13	-13	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
4	-acetate	-acetate	NOUN	NN	Number=Sing	_	_	_	_
5	increased	increase	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
6	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
7	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
8	of	of	ADP	IN	_	_	_	_	_
9	both	both	CCONJ	CC	_	_	_	_	_
10	CD41	CD41	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
11	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
12	and	and	CCONJ	CC	_	_	_	_	_
13	CD61	Cd61	NOUN	NN	Number=Sing	_	_	_	_
14	antigens	antigen	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
15	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3781
# text = Ten-day exposure to Epo induced mature erythroblasts and red cells.
1	Ten	ten	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
2	-day	-day	NOUN	NN	Number=Sing	_	_	_	_
3	exposure	exposure	NOUN	NN	Number=Sing	_	_	_	_
4	to	to	ADP	IN	_	_	_	_	_
5	Epo	Epo	PROPN	NNP	Number=Sing	_	_	_	_
6	induced	induce	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
7	mature	mature	ADJ	JJ	Degree=Pos	_	_	_	_
8	erythroblasts	erythroblast	NOUN	NNS	Number=Plur	_	_	_	_
9	and	and	CCONJ	CC	_	_	_	_	_
10	red	red	ADJ	JJ	Degree=Pos	_	_	_	_
11	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
12	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3782
# text = These benzidine-positive cells were positive for hemoglobin F staining.
1	These	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
2	benzidine	benzidine	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
3	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
4	positive	positive	ADJ	JJ	Degree=Pos	_	_	_	_
5	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
6	were	be	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
7	positive	positive	ADJ	JJ	Degree=Pos	_	_	_	_
8	for	for	ADP	IN	_	_	_	_	_
9	hemoglobin	hemoglobin	NOUN	NN	Number=Sing	_	_	_	_
10	F	f	SCONJ	IN	_	_	_	_	_
11	staining	staining	VERB	VBG	VerbForm=Ger	_	_	_	SpaceAfter=No
12	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3783
# text = Untreated NS-Meg cells expressed mRNA for the Epo receptor (EpoR), for GATA-1, and for alpha 1, alpha 2 and gamma globin genes.
1	Untreated	untreate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
2	NS	N	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
3	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
4	Meg	Meg	PROPN	NNP	Number=Sing	_	_	_	_
5	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
6	expressed	express	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
7	mRNA	mRNa	PROPN	NNP	Number=Sing	_	_	_	_
8	for	for	ADP	IN	_	_	_	_	_
9	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
10	Epo	Epo	PROPN	NNP	Number=Sing	_	_	_	_
11	receptor	receptor	NOUN	NN	Number=Sing	_	_	_	_
12	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
13	EpoR	EpoR	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
14	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
15	,	,	PUNCT	,	_	_	_	_	_
16	for	for	ADP	IN	_	_	_	_	_
17	GATA	GATA	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
18	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
19	1	1	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
20	,	,	PUNCT	,	_	_	_	_	_
21	and	and	CCONJ	CC	_	_	_	_	_
22	for	for	ADP	IN	_	_	_	_	_
23	alpha	alpha	NOUN	NN	Number=Sing	_	_	_	_
24	1	1	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
25	,	,	PUNCT	,	_	_	_	_	_
26	alpha	alpha	NOUN	NN	Number=Sing	_	_	_	_
27	2	2	NUM	CD	NumType=Card	_	_	_	_
28	and	and	CCONJ	CC	_	_	_	_	_
29	gamma	gamma	NOUN	NN	Number=Sing	_	_	_	_
30	globin	globin	NOUN	NN	Number=Sing	_	_	_	_
31	genes	gene	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
32	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3784
# text = These results indicate that NS-Meg cells undergo terminal differentiation of both megakaryocytic and erythroid lineages.
1	These	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
2	results	result	NOUN	NNS	Number=Plur	_	_	_	_
3	indicate	indicate	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
4	that	that	SCONJ	IN	_	_	_	_	_
5	NS	NS	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
6	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
7	Meg	Meg	PROPN	NNP	Number=Sing	_	_	_	_
8	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
9	undergo	undergo	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
10	terminal	terminal	ADJ	JJ	Degree=Pos	_	_	_	_
11	differentiation	differentiation	NOUN	NN	Number=Sing	_	_	_	_
12	of	of	ADP	IN	_	_	_	_	_
13	both	both	CCONJ	CC	_	_	_	_	_
14	megakaryocytic	megakaryocytic	ADJ	JJ	Degree=Pos	_	_	_	_
15	and	and	CCONJ	CC	_	_	_	_	_
16	erythroid	erythroid	ADJ	JJ	Degree=Pos	_	_	_	_
17	lineages	lineage	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
18	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3785
# text = This cell line should be a very useful tool for the investigation of both megakaryocytic and erythroid maturation.
1	This	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
2	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
3	line	line	NOUN	NN	Number=Sing	_	_	_	_
4	should	should	AUX	MD	VerbForm=Fin	_	_	_	_
5	be	be	AUX	VB	VerbForm=Inf	_	_	_	_
6	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
7	very	very	ADV	RB	_	_	_	_	_
8	useful	useful	ADJ	JJ	Degree=Pos	_	_	_	_
9	tool	tool	NOUN	NN	Number=Sing	_	_	_	_
10	for	for	ADP	IN	_	_	_	_	_
11	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
12	investigation	investigation	NOUN	NN	Number=Sing	_	_	_	_
13	of	of	ADP	IN	_	_	_	_	_
14	both	both	CCONJ	CC	_	_	_	_	_
15	megakaryocytic	megakaryocytic	ADJ	JJ	Degree=Pos	_	_	_	_
16	and	and	CCONJ	CC	_	_	_	_	_
17	erythroid	erythroid	ADJ	JJ	Degree=Pos	_	_	_	_
18	maturation	maturation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
19	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 3786
# text = Document 003003583 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	003003583	003003583	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 3787
# text = Cytomegalovirus modulates interleukin-6 gene expression.
1	Cytomegalovirus	Cytomegalovirus	PROPN	NNP	Number=Sing	_	_	_	_
2	modulates	modulate	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
3	interleukin	interleukin	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
4	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
5	6	6	NUM	CD	NumType=Card	_	_	_	_
6	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
7	expression	expression	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
8	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 3788
# text = Complications after lung transplantation include the development of rejection and an increased incidence of infection, particularly with cytomegalovirus (CMV).
1	Complications	complication	NOUN	NNS	Number=Plur	_	_	_	_
2	after	after	ADP	IN	_	_	_	_	_
3	lung	lung	NOUN	NN	Number=Sing	_	_	_	_
4	transplantation	transplantation	NOUN	NN	Number=Sing	_	_	_	_
5	include	include	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
6	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
7	development	development	NOUN	NN	Number=Sing	_	_	_	_
8	of	of	ADP	IN	_	_	_	_	_
9	rejection	rejection	NOUN	NN	Number=Sing	_	_	_	_
10	and	and	CCONJ	CC	_	_	_	_	_
11	an	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
12	increased	increased	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
13	incidence	incidence	NOUN	NN	Number=Sing	_	_	_	_
14	of	of	ADP	IN	_	_	_	_	_
15	infection	infection	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
16	,	,	PUNCT	,	_	_	_	_	_
17	particularly	particularly	ADV	RB	_	_	_	_	_
18	with	with	ADP	IN	_	_	_	_	_
19	cytomegalovirus	cytomegalovirus	NOUN	NN	Number=Sing	_	_	_	_
20	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
21	CMV	CMV	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
22	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
23	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3789
# text = Several recent studies have suggested that interleukin (IL)-6 may be used to detect both infection and rejection after lung transplantation.
1	Several	several	ADJ	JJ	Degree=Pos	_	_	_	_
2	recent	recent	ADJ	JJ	Degree=Pos	_	_	_	_
3	studies	study	NOUN	NNS	Number=Plur	_	_	_	_
4	have	have	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
5	suggested	suggest	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
6	that	that	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
7	interleukin	interleukin	NOUN	NN	Number=Sing	_	_	_	_
8	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
9	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
10	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
11	-	-	SYM	SYM	_	_	_	_	SpaceAfter=No
12	6	6	NUM	CD	NumType=Card	_	_	_	_
13	may	may	AUX	MD	VerbForm=Fin	_	_	_	_
14	be	be	AUX	VB	VerbForm=Inf	_	_	_	_
15	used	use	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
16	to	to	PART	TO	_	_	_	_	_
17	detect	detect	VERB	VB	VerbForm=Inf	_	_	_	_
18	both	both	CCONJ	CC	_	_	_	_	_
19	infection	infection	NOUN	NN	Number=Sing	_	_	_	_
20	and	and	CCONJ	CC	_	_	_	_	_
21	rejection	rejection	NOUN	NN	Number=Sing	_	_	_	_
22	after	after	ADP	IN	_	_	_	_	_
23	lung	lung	NOUN	NN	Number=Sing	_	_	_	_
24	transplantation	transplantation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
25	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3790
# text = In addition, IL-6 may play a role in the development of bronchiolitis obliterans after transplantation.
1	In	in	ADP	IN	_	_	_	_	_
2	addition	addition	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
3	,	,	PUNCT	,	_	_	_	_	_
4	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
5	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
6	6	6	NUM	CD	NumType=Card	_	_	_	_
7	may	may	AUX	MD	VerbForm=Fin	_	_	_	_
8	play	play	VERB	VB	VerbForm=Inf	_	_	_	_
9	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
10	role	role	NOUN	NN	Number=Sing	_	_	_	_
11	in	in	ADP	IN	_	_	_	_	_
12	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
13	development	development	NOUN	NN	Number=Sing	_	_	_	_
14	of	of	ADP	IN	_	_	_	_	_
15	bronchiolitis	bronchiolitis	NOUN	NN	Number=Sing	_	_	_	_
16	obliterans	obliteran	NOUN	NNS	Number=Plur	_	_	_	_
17	after	after	ADP	IN	_	_	_	_	_
18	transplantation	transplantation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
19	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3791
# text = Because CMV is also associated with the development of bronchiolitis obliterans after transplantation, we determined whether CMV induces IL-6 gene expression.
1	Because	because	SCONJ	IN	_	_	_	_	_
2	CMV	CMV	PROPN	NNP	Number=Sing	_	_	_	_
3	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
4	also	also	ADV	RB	_	_	_	_	_
5	associated	associate	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
6	with	with	ADP	IN	_	_	_	_	_
7	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
8	development	development	NOUN	NN	Number=Sing	_	_	_	_
9	of	of	ADP	IN	_	_	_	_	_
10	bronchiolitis	bronchiolitis	NOUN	NN	Number=Sing	_	_	_	_
11	obliterans	obliteran	NOUN	NNS	Number=Plur	_	_	_	_
12	after	after	ADP	IN	_	_	_	_	_
13	transplantation	transplantation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
14	,	,	PUNCT	,	_	_	_	_	_
15	we	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
16	determined	determine	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
17	whether	whether	SCONJ	IN	_	_	_	_	_
18	CMV	CMV	PROPN	NNP	Number=Sing	_	_	_	_
19	induces	induce	PROPN	NNPS	Number=Plur	_	_	_	_
20	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
21	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
22	6	6	NUM	CD	NumType=Card	_	_	_	_
23	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
24	expression	expression	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
25	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3792
# text = We demonstrated that CMV infection increased both IL-6 protein and mRNA in peripheral blood mononuclear cells.
1	We	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
2	demonstrated	demonstrate	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
3	that	that	SCONJ	IN	_	_	_	_	_
4	CMV	CMV	PROPN	NNP	Number=Sing	_	_	_	_
5	infection	infection	NOUN	NN	Number=Sing	_	_	_	_
6	increased	increase	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
7	both	both	CCONJ	CC	_	_	_	_	_
8	IL	Il	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
9	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
10	6	6	NUM	CD	NumType=Card	_	_	_	_
11	protein	protein	NOUN	NN	Number=Sing	_	_	_	_
12	and	and	CCONJ	CC	_	_	_	_	_
13	mRNA	mRNa	NOUN	NN	Number=Sing	_	_	_	_
14	in	in	ADP	IN	_	_	_	_	_
15	peripheral	peripheral	ADJ	JJ	Degree=Pos	_	_	_	_
16	blood	blood	NOUN	NN	Number=Sing	_	_	_	_
17	mononuclear	mononuclear	ADJ	JJ	Degree=Pos	_	_	_	_
18	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
19	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3793
# text = We also demonstrated that the CMV immediate early 1 gene product increased expression of the IL-6 promoter.
1	We	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
2	also	also	ADV	RB	_	_	_	_	_
3	demonstrated	demonstrate	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
4	that	that	SCONJ	IN	_	_	_	_	_
5	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
6	CMV	Cmv	NOUN	NN	Number=Sing	_	_	_	_
7	immediate	immediate	ADJ	JJ	Degree=Pos	_	_	_	_
8	early	early	ADV	RB	Degree=Pos	_	_	_	_
9	1	1	NUM	CD	NumType=Card	_	_	_	_
10	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
11	product	product	NOUN	NN	Number=Sing	_	_	_	_
12	increased	increase	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
13	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
14	of	of	ADP	IN	_	_	_	_	_
15	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
16	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
17	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
18	6	6	NUM	CD	NumType=Card	_	_	_	_
19	promoter	promoter	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
20	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3794
# text = This effect of the CMV immediate early 1 gene product was dependent upon the presence of specific transcription factor binding sites in the IL-6 promoter.
1	This	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
2	effect	effect	NOUN	NN	Number=Sing	_	_	_	_
3	of	of	ADP	IN	_	_	_	_	_
4	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
5	CMV	CMV	PROPN	NNP	Number=Sing	_	_	_	_
6	immediate	immediate	ADJ	JJ	Degree=Pos	_	_	_	_
7	early	early	ADJ	JJ	Degree=Pos	_	_	_	_
8	1	1	NUM	CD	NumType=Card	_	_	_	_
9	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
10	product	product	NOUN	NN	Number=Sing	_	_	_	_
11	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
12	dependent	dependent	ADJ	JJ	Degree=Pos	_	_	_	_
13	upon	upon	ADP	IN	_	_	_	_	_
14	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
15	presence	presence	NOUN	NN	Number=Sing	_	_	_	_
16	of	of	ADP	IN	_	_	_	_	_
17	specific	specific	ADJ	JJ	Degree=Pos	_	_	_	_
18	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
19	factor	factor	NOUN	NN	Number=Sing	_	_	_	_
20	binding	bind	VERB	VBG	VerbForm=Ger	_	_	_	_
21	sites	site	NOUN	NNS	Number=Plur	_	_	_	_
22	in	in	ADP	IN	_	_	_	_	_
23	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
24	IL	IL	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
25	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
26	6	6	NUM	CD	NumType=Card	_	_	_	_
27	promoter	promoter	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
28	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3795
# text = These studies demonstrate that CMV may be an important cofactor in the development of rejection and infection after transplantation through its effects on IL-6.
1	These	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
2	studies	study	NOUN	NNS	Number=Plur	_	_	_	_
3	demonstrate	demonstrate	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
4	that	that	SCONJ	IN	_	_	_	_	_
5	CMV	CMV	PROPN	NNP	Number=Sing	_	_	_	_
6	may	may	AUX	MD	VerbForm=Fin	_	_	_	_
7	be	be	AUX	VB	VerbForm=Inf	_	_	_	_
8	an	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
9	important	important	ADJ	JJ	Degree=Pos	_	_	_	_
10	cofactor	cofactor	NOUN	NN	Number=Sing	_	_	_	_
11	in	in	ADP	IN	_	_	_	_	_
12	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
13	development	development	NOUN	NN	Number=Sing	_	_	_	_
14	of	of	ADP	IN	_	_	_	_	_
15	rejection	rejection	NOUN	NN	Number=Sing	_	_	_	_
16	and	and	CCONJ	CC	_	_	_	_	_
17	infection	infection	NOUN	NN	Number=Sing	_	_	_	_
18	after	after	ADP	IN	_	_	_	_	_
19	transplantation	transplantation	NOUN	NN	Number=Sing	_	_	_	_
20	through	through	ADP	IN	_	_	_	_	_
21	its	its	PRON	PRP$	Gender=Neut|Number=Sing|Person=3|Poss=Yes|PronType=Prs	_	_	_	_
22	effects	effect	NOUN	NNS	Number=Plur	_	_	_	_
23	on	on	ADP	IN	_	_	_	_	_
24	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
25	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
26	6	6	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
27	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 3796
# text = Document 003003585 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	003003585	003003585	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 3797
# text = Signal transduction pathways in normal human monocytes stimulated by cytokines and mediators: comparative study with normal human neutrophils or transformed cells and the putative roles in functionality and cell biology.
1	Signal	signal	ADJ	JJ	Degree=Pos	_	_	_	_
2	transduction	transduction	NOUN	NN	Number=Sing	_	_	_	_
3	pathways	pathway	NOUN	NNS	Number=Plur	_	_	_	_
4	in	in	ADP	IN	_	_	_	_	_
5	normal	normal	ADJ	JJ	Degree=Pos	_	_	_	_
6	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
7	monocytes	monocyte	NOUN	NNS	Number=Plur	_	_	_	_
8	stimulated	stimulate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
9	by	by	ADP	IN	_	_	_	_	_
10	cytokines	cytokine	NOUN	NNS	Number=Plur	_	_	_	_
11	and	and	CCONJ	CC	_	_	_	_	_
12	mediators	mediator	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
13	:	:	PUNCT	:	_	_	_	_	_
14	comparative	comparative	ADJ	JJ	Degree=Pos	_	_	_	_
15	study	study	NOUN	NN	Number=Sing	_	_	_	_
16	with	with	ADP	IN	_	_	_	_	_
17	normal	normal	ADJ	JJ	Degree=Pos	_	_	_	_
18	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
19	neutrophils	neutrophil	NOUN	NNS	Number=Plur	_	_	_	_
20	or	or	CCONJ	CC	_	_	_	_	_
21	transformed	transform	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
22	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
23	and	and	CCONJ	CC	_	_	_	_	_
24	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
25	putative	putative	ADJ	JJ	Degree=Pos	_	_	_	_
26	roles	role	NOUN	NNS	Number=Plur	_	_	_	_
27	in	in	ADP	IN	_	_	_	_	_
28	functionality	functionality	NOUN	NN	Number=Sing	_	_	_	_
29	and	and	CCONJ	CC	_	_	_	_	_
30	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
31	biology	biology	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
32	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 3798
# text = Granulocyte-macrophage colony-stimulating factor (GM-CSF) and interleukin (IL) -3 induced tyrosine phosphorylation of 92-kDa protein in normal human monocytes.
1	Granulocyte	Granulocyte	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
2	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
3	macrophage	macrophage	NOUN	NN	Number=Sing	_	_	_	_
4	colony	colony	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
5	-stimulating	-stimulating	VERB	VBG	VerbForm=Ger	_	_	_	_
6	factor	factor	NOUN	NN	Number=Sing	_	_	_	_
7	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
8	GM	GM	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
9	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
10	CSF	CSF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
11	)	)	PUNCT	-RRB-	_	_	_	_	_
12	and	and	CCONJ	CC	_	_	_	_	_
13	interleukin	interleukin	NOUN	NN	Number=Sing	_	_	_	_
14	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
15	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
16	)	)	PUNCT	-RRB-	_	_	_	_	_
17	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
18	3	3	X	LS	_	_	_	_	_
19	induced	induce	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
20	tyrosine	tyrosine	NOUN	NN	Number=Sing	_	_	_	_
21	phosphorylation	phosphorylation	NOUN	NN	Number=Sing	_	_	_	_
22	of	of	ADP	IN	_	_	_	_	_
23	92	92	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
24	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
25	kDa	kDa	NOUN	NN	Number=Sing	_	_	_	_
26	protein	protein	NOUN	NN	Number=Sing	_	_	_	_
27	in	in	ADP	IN	_	_	_	_	_
28	normal	normal	ADJ	JJ	Degree=Pos	_	_	_	_
29	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
30	monocytes	monocyte	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
31	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3799
# text = We identified this 92-kDa protein as STAT5, but not as STATs1, 3, and 6 nor c-fes and vav protooncogene products, and demonstrated its translocation to the nucleus, enhancement of specific DNA binding capacity, and potentiation of trancriptional activity by GM-CSF.
1	We	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
2	identified	identify	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
3	this	this	PRON	DT	Number=Sing|PronType=Dem	_	_	_	_
4	92	92	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
5	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
6	kDa	kDa	NOUN	NN	Number=Sing	_	_	_	_
7	protein	protein	NOUN	NN	Number=Sing	_	_	_	_
8	as	as	ADP	IN	_	_	_	_	_
9	STAT5	STAT5	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
10	,	,	PUNCT	,	_	_	_	_	_
11	but	but	CCONJ	CC	_	_	_	_	_
12	not	not	ADV	RB	_	_	_	_	_
13	as	as	ADP	IN	_	_	_	_	_
14	STATs1	STATs1	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
15	,	,	PUNCT	,	_	_	_	_	_
16	3	3	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
17	,	,	PUNCT	,	_	_	_	_	_
18	and	and	CCONJ	CC	_	_	_	_	_
19	6	6	NUM	CD	NumType=Card	_	_	_	_
20	nor	nor	CCONJ	CC	_	_	_	_	_
21	c	c	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
22	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
23	fes	fe	NOUN	NNS	Number=Plur	_	_	_	_
24	and	and	CCONJ	CC	_	_	_	_	_
25	vav	vave	NOUN	NN	Number=Sing	_	_	_	_
26	protooncogene	protooncogene	NOUN	NN	Number=Sing	_	_	_	_
27	products	product	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
28	,	,	PUNCT	,	_	_	_	_	_
29	and	and	CCONJ	CC	_	_	_	_	_
30	demonstrated	demonstrate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
31	its	its	PRON	PRP$	Gender=Neut|Number=Sing|Person=3|Poss=Yes|PronType=Prs	_	_	_	_
32	translocation	translocation	NOUN	NN	Number=Sing	_	_	_	_
33	to	to	ADP	IN	_	_	_	_	_
34	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
35	nucleus	nucleus	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
36	,	,	PUNCT	,	_	_	_	_	_
37	enhancement	enhancement	NOUN	NN	Number=Sing	_	_	_	_
38	of	of	ADP	IN	_	_	_	_	_
39	specific	specific	ADJ	JJ	Degree=Pos	_	_	_	_
40	DNA	dna	NOUN	NN	Number=Sing	_	_	_	_
41	binding	binding	VERB	VBG	VerbForm=Ger	_	_	_	_
42	capacity	capacity	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
43	,	,	PUNCT	,	_	_	_	_	_
44	and	and	CCONJ	CC	_	_	_	_	_
45	potentiation	potentiation	NOUN	NN	Number=Sing	_	_	_	_
46	of	of	ADP	IN	_	_	_	_	_
47	trancriptional	trancriptional	ADJ	JJ	Degree=Pos	_	_	_	_
48	activity	activity	NOUN	NN	Number=Sing	_	_	_	_
49	by	by	ADP	IN	_	_	_	_	_
50	GM	GM	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
51	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
52	CSF	CSF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
53	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3800
# text = N-formyl-methionyl-leucyl-phenylalanine (FMLP) and phorbol myristate acetate (PMA) induced tyrosine phosphorylation of 42- and 44-kDa proteins, which were identified as extracellular signal-regulated kinase (ERK), in human monocytes.
1	N-formyl-methionyl-leucyl-phenylalanine	N-formyl-methionyl-leucyl-phenylalanine	PROPN	NNP	Number=Sing	_	_	_	_
2	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
3	FMLP	FMLP	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
4	)	)	PUNCT	-RRB-	_	_	_	_	_
5	and	and	CCONJ	CC	_	_	_	_	_
6	phorbol	phorbol	NOUN	NN	Number=Sing	_	_	_	_
7	myristate	myristate	NOUN	NN	Number=Sing	_	_	_	_
8	acetate	acetate	NOUN	NN	Number=Sing	_	_	_	_
9	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
10	PMA	PMA	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
11	)	)	PUNCT	-RRB-	_	_	_	_	_
12	induced	induce	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
13	tyrosine	tyrosine	NOUN	NN	Number=Sing	_	_	_	_
14	phosphorylation	phosphorylation	NOUN	NN	Number=Sing	_	_	_	_
15	of	of	ADP	IN	_	_	_	_	_
16	42	42	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
17	-	-	PUNCT	,	_	_	_	_	_
18	and	and	CCONJ	CC	_	_	_	_	_
19	44	44	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
20	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
21	kDa	kDa	NOUN	NN	Number=Sing	_	_	_	_
22	proteins	protein	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
23	,	,	PUNCT	,	_	_	_	_	_
24	which	which	PRON	WDT	PronType=Rel	_	_	_	_
25	were	be	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
26	identified	identify	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
27	as	as	ADP	IN	_	_	_	_	_
28	extracellular	extracellular	ADJ	JJ	Degree=Pos	_	_	_	_
29	signal	signal	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
30	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
31	regulated	regulate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
32	kinase	kinase	NOUN	NN	Number=Sing	_	_	_	_
33	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
34	ERK	ERK	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
35	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
36	,	,	PUNCT	,	_	_	_	_	_
37	in	in	ADP	IN	_	_	_	_	_
38	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
39	monocytes	monocyte	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
40	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3801
# text = In marked contrast to neutrophils and MO7e cells, GM-CSF did not induce tyrosine phosphorylation and activation of ERK in monocytes.
1	In	in	ADP	IN	_	_	_	_	_
2	marked	mark	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
3	contrast	contrast	NOUN	NN	Number=Sing	_	_	_	_
4	to	to	ADP	IN	_	_	_	_	_
5	neutrophils	neutrophil	NOUN	NNS	Number=Plur	_	_	_	_
6	and	and	CCONJ	CC	_	_	_	_	_
7	MO7e	MO7e	NOUN	NN	Number=Sing	_	_	_	_
8	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
9	,	,	PUNCT	,	_	_	_	_	_
10	GM	GM	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
11	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
12	CSF	CSF	PROPN	NNP	Number=Sing	_	_	_	_
13	did	do	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
14	not	not	PART	RB	_	_	_	_	_
15	induce	induce	VERB	VB	VerbForm=Inf	_	_	_	_
16	tyrosine	tyrosine	NOUN	NN	Number=Sing	_	_	_	_
17	phosphorylation	phosphorylation	NOUN	NN	Number=Sing	_	_	_	_
18	and	and	CCONJ	CC	_	_	_	_	_
19	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
20	of	of	ADP	IN	_	_	_	_	_
21	ERK	ERK	PROPN	NNP	Number=Sing	_	_	_	_
22	in	in	ADP	IN	_	_	_	_	_
23	monocytes	monocyte	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
24	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3802
# text = Among upstream signaling molecules of ERK, Shc was constitutively associated with Grb2 and was not tyrosine-phosphorylated by GM-CSF and FMLP, and Sos1 and c-Raf-1 were not phosphorylated by GM-CSF, IL-3, TNF, and FMLP in monocytes, whereas all these signaling molecules were affected and/or utilized by GM-CSF in MO7e cells.
1	Among	among	ADP	IN	_	_	_	_	_
2	upstream	upstream	ADJ	JJ	Degree=Pos	_	_	_	_
3	signaling	signaling	NOUN	NN	Number=Sing	_	_	_	_
4	molecules	molecule	NOUN	NNS	Number=Plur	_	_	_	_
5	of	of	ADP	IN	_	_	_	_	_
6	ERK	ERK	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
7	,	,	PUNCT	,	_	_	_	_	_
8	Shc	Shc	PROPN	NNP	Number=Sing	_	_	_	_
9	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
10	constitutively	constitutively	ADV	RB	_	_	_	_	_
11	associated	associate	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
12	with	with	ADP	IN	_	_	_	_	_
13	Grb2	Grb2	NOUN	NN	Number=Sing	_	_	_	_
14	and	and	CCONJ	CC	_	_	_	_	_
15	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
16	not	not	PART	RB	_	_	_	_	_
17	tyrosine	tyrosine	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
18	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
19	phosphorylated	phosphorylate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
20	by	by	ADP	IN	_	_	_	_	_
21	GM	GM	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
22	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
23	CSF	CSF	PROPN	NNP	Number=Sing	_	_	_	_
24	and	and	CCONJ	CC	_	_	_	_	_
25	FMLP	FMLP	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
26	,	,	PUNCT	,	_	_	_	_	_
27	and	and	CCONJ	CC	_	_	_	_	_
28	Sos1	Sos1	PROPN	NNP	Number=Sing	_	_	_	_
29	and	and	CCONJ	CC	_	_	_	_	_
30	c-	c-	SYM	NFP	_	_	_	_	SpaceAfter=No
31	Raf	Raf	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
32	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
33	1	1	NUM	CD	NumType=Card	_	_	_	_
34	were	be	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
35	not	not	PART	RB	_	_	_	_	_
36	phosphorylated	phosphorylate	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
37	by	by	ADP	IN	_	_	_	_	_
38	GM	GM	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
39	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
40	CSF	CSF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
41	,	,	PUNCT	,	_	_	_	_	_
42	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
43	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
44	3	3	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
45	,	,	PUNCT	,	_	_	_	_	_
46	TNF	TNF	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
47	,	,	PUNCT	,	_	_	_	_	_
48	and	and	CCONJ	CC	_	_	_	_	_
49	FMLP	FMLP	NOUN	NN	Number=Sing	_	_	_	_
50	in	in	ADP	IN	_	_	_	_	_
51	monocytes	monocytes	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
52	,	,	PUNCT	,	_	_	_	_	_
53	whereas	whereas	SCONJ	IN	_	_	_	_	_
54	all	all	DET	DT	_	_	_	_	_
55	these	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
56	signaling	signaling	NOUN	NN	Number=Sing	_	_	_	_
57	molecules	molecule	NOUN	NNS	Number=Plur	_	_	_	_
58	were	be	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
59	affected	affect	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
60	and	and	CCONJ	CC	_	_	_	_	SpaceAfter=No
61	/	/	PUNCT	,	_	_	_	_	SpaceAfter=No
62	or	or	CCONJ	CC	_	_	_	_	_
63	utilized	utilize	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
64	by	by	ADP	IN	_	_	_	_	_
65	GM	GM	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
66	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
67	CSF	CSF	PROPN	NNP	Number=Sing	_	_	_	_
68	in	in	ADP	IN	_	_	_	_	_
69	MO7e	MO7e	PROPN	NNP	Number=Sing	_	_	_	_
70	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
71	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3803
# text = In contrast to neutrophils, p38 was constitutively phosphorylated and agonist-dependent phosphorylation and activation was not detected in human monocytes.
1	In	in	ADP	IN	_	_	_	_	_
2	contrast	contrast	NOUN	NN	Number=Sing	_	_	_	_
3	to	to	ADP	IN	_	_	_	_	_
4	neutrophils	neutrophil	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
5	,	,	PUNCT	,	_	_	_	_	_
6	p38	p38	NUM	CD	NumType=Card	_	_	_	_
7	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
8	constitutively	constitutively	ADV	RB	_	_	_	_	_
9	phosphorylated	phosphorylate	ADJ	JJ	Degree=Pos	_	_	_	_
10	and	and	CCONJ	CC	_	_	_	_	_
11	agonist	agonist	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
12	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
13	dependent	dependent	ADJ	JJ	Degree=Pos	_	_	_	_
14	phosphorylation	phosphorylation	NOUN	NN	Number=Sing	_	_	_	_
15	and	and	CCONJ	CC	_	_	_	_	_
16	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
17	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
18	not	not	PART	RB	_	_	_	_	_
19	detected	detect	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
20	in	in	ADP	IN	_	_	_	_	_
21	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
22	monocytes	monocyte	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
23	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3804
# text = Superoxide release stimulated by FMLP was inhibited partially by PD98059 or SB203580, a specific inhibitor of ERK or p38 pathway, and was almost completely inhibited by the combination of both inhibitors, whereas PMA-induced superoxide release was resistant to these two inhibitors in monocytes.
1	Superoxide	Superoxide	ADJ	JJ	Degree=Pos	_	_	_	_
2	release	release	NOUN	NN	Number=Sing	_	_	_	_
3	stimulated	stimulate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
4	by	by	ADP	IN	_	_	_	_	_
5	FMLP	FMLP	PROPN	NNP	Number=Sing	_	_	_	_
6	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
7	inhibited	inhibit	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
8	partially	partially	ADV	RB	_	_	_	_	_
9	by	by	ADP	IN	_	_	_	_	_
10	PD98059	PD98059	PROPN	NNP	Number=Sing	_	_	_	_
11	or	or	CCONJ	CC	_	_	_	_	_
12	SB	Sb	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
13	203580	203580	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
14	,	,	PUNCT	,	_	_	_	_	_
15	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
16	specific	specific	ADJ	JJ	Degree=Pos	_	_	_	_
17	inhibitor	inhibitor	NOUN	NN	Number=Sing	_	_	_	_
18	of	of	ADP	IN	_	_	_	_	_
19	ERK	ERK	PROPN	NNP	Number=Sing	_	_	_	_
20	or	or	CCONJ	CC	_	_	_	_	_
21	p38	p38	NUM	CD	NumType=Card	_	_	_	_
22	pathway	pathway	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
23	,	,	PUNCT	,	_	_	_	_	_
24	and	and	CCONJ	CC	_	_	_	_	_
25	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
26	almost	almost	ADV	RB	_	_	_	_	_
27	completely	completely	ADV	RB	_	_	_	_	_
28	inhibited	inhibit	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
29	by	by	ADP	IN	_	_	_	_	_
30	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
31	combination	combination	NOUN	NN	Number=Sing	_	_	_	_
32	of	of	ADP	IN	_	_	_	_	_
33	both	both	DET	DT	_	_	_	_	_
34	inhibitors	inhibitor	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
35	,	,	PUNCT	,	_	_	_	_	_
36	whereas	whereas	SCONJ	IN	_	_	_	_	_
37	PMA	PMA	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
38	-induced	-induce	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
39	superoxide	superoxide	ADJ	JJ	Degree=Pos	_	_	_	_
40	release	release	NOUN	NN	Number=Sing	_	_	_	_
41	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
42	resistant	resistant	ADJ	JJ	Degree=Pos	_	_	_	_
43	to	to	ADP	IN	_	_	_	_	_
44	these	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
45	two	two	NUM	CD	NumType=Card	_	_	_	_
46	inhibitors	inhibitor	NOUN	NNS	Number=Plur	_	_	_	_
47	in	in	ADP	IN	_	_	_	_	_
48	monocytes	monocyte	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
49	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3805
# text = PD98059 inhibited GM-CSF-dependent proliferation of MO7e cells.
1	PD98059	Pd98059	NOUN	NN	Number=Sing	_	_	_	_
2	inhibited	inhibit	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
3	GM-	GM-	PUNCT	,	_	_	_	_	SpaceAfter=No
4	CSF	CSF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
5	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
6	dependent	dependent	ADJ	JJ	Degree=Pos	_	_	_	_
7	proliferation	proliferation	NOUN	NN	Number=Sing	_	_	_	_
8	of	of	ADP	IN	_	_	_	_	_
9	MO7e	MO7e	ADJ	JJ	Degree=Pos	_	_	_	_
10	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
11	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3806
# text = Present results indicate trancriptional roles of STAT5 and functional roles of ERK and/or p38 in normal human monocytes stimulated by physiological receptor-mediated agonists GM-CSF and FMLP.
1	Present	present	ADJ	JJ	Degree=Pos	_	_	_	_
2	results	result	NOUN	NNS	Number=Plur	_	_	_	_
3	indicate	indicate	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
4	trancriptional	trancriptional	ADJ	JJ	Degree=Pos	_	_	_	_
5	roles	role	NOUN	NNS	Number=Plur	_	_	_	_
6	of	of	ADP	IN	_	_	_	_	_
7	STAT5	stat5	PROPN	NNP	Number=Sing	_	_	_	_
8	and	and	CCONJ	CC	_	_	_	_	_
9	functional	functional	ADJ	JJ	Degree=Pos	_	_	_	_
10	roles	role	NOUN	NNS	Number=Plur	_	_	_	_
11	of	of	ADP	IN	_	_	_	_	_
12	ERK	ERK	PROPN	NNP	Number=Sing	_	_	_	_
13	and	and	CCONJ	CC	_	_	_	_	SpaceAfter=No
14	/	/	PUNCT	,	_	_	_	_	SpaceAfter=No
15	or	or	CCONJ	CC	_	_	_	_	_
16	p38	p38	NUM	CD	NumType=Card	_	_	_	_
17	in	in	ADP	IN	_	_	_	_	_
18	normal	normal	ADJ	JJ	Degree=Pos	_	_	_	_
19	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
20	monocytes	monocyte	NOUN	NNS	Number=Plur	_	_	_	_
21	stimulated	stimulate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
22	by	by	ADP	IN	_	_	_	_	_
23	physiological	physiological	ADJ	JJ	Degree=Pos	_	_	_	_
24	receptor	receptor	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
25	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
26	mediated	mediate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
27	agonists	agonist	NOUN	NNS	Number=Plur	_	_	_	_
28	GM	GM	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
29	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
30	CSF	CSF	PROPN	NNP	Number=Sing	_	_	_	_
31	and	and	CCONJ	CC	_	_	_	_	_
32	FMLP	FMLP	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
33	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3807
# text = Possible roles of ERK in proliferation of transformed cells were also suggested.
1	Possible	possible	ADJ	JJ	Degree=Pos	_	_	_	_
2	roles	role	NOUN	NNS	Number=Plur	_	_	_	_
3	of	of	ADP	IN	_	_	_	_	_
4	ERK	ERK	PROPN	NNP	Number=Sing	_	_	_	_
5	in	in	ADP	IN	_	_	_	_	_
6	proliferation	proliferation	NOUN	NN	Number=Sing	_	_	_	_
7	of	of	ADP	IN	_	_	_	_	_
8	transformed	transformed	ADJ	JJ	Degree=Pos	_	_	_	_
9	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
10	were	be	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
11	also	also	ADV	RB	_	_	_	_	_
12	suggested	suggest	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	SpaceAfter=No
13	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 3808
# text = Document 003003587 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	003003587	003003587	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 3809
# text = Elevated cyclic AMP inhibits NF-kappaB-mediated transcription in human monocytic cells and endothelial cells.
1	Elevated	elevate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
2	cyclic	cyclic	ADJ	JJ	Degree=Pos	_	_	_	_
3	AMP	Amp	NOUN	NN	Number=Sing	_	_	_	_
4	inhibits	inhibit	NOUN	NNS	Number=Plur	_	_	_	_
5	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
6	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
7	kappaB-	kappaB-	SYM	SYM	_	_	_	_	SpaceAfter=No
8	mediated	mediate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
9	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
10	in	in	ADP	IN	_	_	_	_	_
11	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
12	monocytic	monocytic	ADJ	JJ	Degree=Pos	_	_	_	_
13	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
14	and	and	CCONJ	CC	_	_	_	_	_
15	endothelial	endothelial	ADJ	JJ	Degree=Pos	_	_	_	_
16	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
17	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 3810
# text = The NF-kappaB/Rel family of transcription factors regulates the inducible expression of many genes in activated human monocytes and endothelial cells.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
3	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
4	kappaB	kappaB	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
5	/	/	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
6	Rel	Rel	PROPN	NNP	Number=Sing	_	_	_	_
7	family	family	NOUN	NN	Number=Sing	_	_	_	_
8	of	of	ADP	IN	_	_	_	_	_
9	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
10	factors	factor	NOUN	NNS	Number=Plur	_	_	_	_
11	regulates	regulate	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
12	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
13	inducible	inducible	ADJ	JJ	Degree=Pos	_	_	_	_
14	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
15	of	of	ADP	IN	_	_	_	_	_
16	many	many	ADJ	JJ	Degree=Pos	_	_	_	_
17	genes	gene	NOUN	NNS	Number=Plur	_	_	_	_
18	in	in	ADP	IN	_	_	_	_	_
19	activated	activated	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
20	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
21	monocytes	monocyte	NOUN	NNS	Number=Plur	_	_	_	_
22	and	and	CCONJ	CC	_	_	_	_	_
23	endothelial	endothelial	ADJ	JJ	Degree=Pos	_	_	_	_
24	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
25	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3811
# text = In this study, we examined the molecular mechanism by which agents that elevate intracellular cAMP inhibit the expression of the tumor necrosis factor alpha (TNFalpha), tissue factor, endothelial leukocyte adhesion molecule-1, and vascular cell adhesion molecule-1 genes.
1	In	in	ADP	IN	_	_	_	_	_
2	this	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
3	study	study	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
4	,	,	PUNCT	,	_	_	_	_	_
5	we	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
6	examined	examin	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
7	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
8	molecular	molecular	ADJ	JJ	Degree=Pos	_	_	_	_
9	mechanism	mechanism	NOUN	NN	Number=Sing	_	_	_	_
10	by	by	ADP	IN	_	_	_	_	_
11	which	which	DET	WDT	PronType=Int	_	_	_	_
12	agents	agent	NOUN	NNS	Number=Plur	_	_	_	_
13	that	that	PRON	WDT	PronType=Rel	_	_	_	_
14	elevate	elevate	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
15	intracellular	intracellular	ADJ	JJ	Degree=Pos	_	_	_	_
16	cAMP	camp	NOUN	NNS	Number=Plur	_	_	_	_
17	inhibit	inhibit	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
18	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
19	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
20	of	of	ADP	IN	_	_	_	_	_
21	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
22	tumor	tumor	NOUN	NN	Number=Sing	_	_	_	_
23	necrosis	necrosis	NOUN	NN	Number=Sing	_	_	_	_
24	factor	factor	NOUN	NN	Number=Sing	_	_	_	_
25	alpha	alpha	NOUN	NN	Number=Sing	_	_	_	_
26	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
27	TNFalpha	TNFalpha	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
28	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
29	,	,	PUNCT	,	_	_	_	_	_
30	tissue	tissue	ADP	IN	_	_	_	_	_
31	factor	factor	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
32	,	,	PUNCT	,	_	_	_	_	_
33	endothelial	endothelial	ADJ	JJ	Degree=Pos	_	_	_	_
34	leukocyte	leukocyte	NOUN	NN	Number=Sing	_	_	_	_
35	adhesion	adhesion	NOUN	NN	Number=Sing	_	_	_	_
36	molecule	molecule	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
37	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
38	1	1	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
39	,	,	PUNCT	,	_	_	_	_	_
40	and	and	CCONJ	CC	_	_	_	_	_
41	vascular	vascular	ADJ	JJ	Degree=Pos	_	_	_	_
42	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
43	adhesion	adhesion	NOUN	NN	Number=Sing	_	_	_	_
44	molecule	molecule	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
45	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
46	1	1	NUM	CD	NumType=Card	_	_	_	_
47	genes	gene	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
48	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3812
# text = Both forskolin and dibutyryl cAMP, which elevate intracellular cAMP by independent mechanisms, inhibited TNFalpha and tissue factor expression at the level of transcription.
1	Both	both	DET	DT	_	_	_	_	_
2	forskolin	forskolin	NOUN	NN	Number=Sing	_	_	_	_
3	and	and	CCONJ	CC	_	_	_	_	_
4	dibutyryl	dibutyryl	NOUN	NN	Number=Sing	_	_	_	_
5	cAMP	camp	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
6	,	,	PUNCT	,	_	_	_	_	_
7	which	which	PRON	WDT	PronType=Rel	_	_	_	_
8	elevate	elevate	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
9	intracellular	intracellular	ADJ	JJ	Degree=Pos	_	_	_	_
10	cAMP	camp	NOUN	NNS	Number=Plur	_	_	_	_
11	by	by	ADP	IN	_	_	_	_	_
12	independent	independent	ADJ	JJ	Degree=Pos	_	_	_	_
13	mechanisms	mechanism	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
14	,	,	PUNCT	,	_	_	_	_	_
15	inhibited	inhibit	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
16	TNFalpha	TNFalpha	PROPN	NNP	Number=Sing	_	_	_	_
17	and	and	CCONJ	CC	_	_	_	_	_
18	tissue	tissue	ADJ	JJ	Degree=Pos	_	_	_	_
19	factor	factor	NOUN	NN	Number=Sing	_	_	_	_
20	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
21	at	at	ADP	IN	_	_	_	_	_
22	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
23	level	level	NOUN	NN	Number=Sing	_	_	_	_
24	of	of	ADP	IN	_	_	_	_	_
25	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
26	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3813
# text = Induction of NF-kappaB-dependent gene expression in transiently transfected human monocytic THP-1 cells and human umbilical vein endothelial cells was inhibited by elevated cAMP and by overexpression of the catalytic subunit of protein kinase A (PKA).
1	Induction	Induction	NOUN	NN	Number=Sing	_	_	_	_
2	of	of	ADP	IN	_	_	_	_	_
3	NF-kappaB	Nf-kappab	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
4	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
5	dependent	dependent	ADJ	JJ	Degree=Pos	_	_	_	_
6	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
7	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
8	in	in	ADP	IN	_	_	_	_	_
9	transiently	transiently	ADV	RB	_	_	_	_	_
10	transfected	transfect	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
11	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
12	monocytic	monocytic	ADJ	JJ	Degree=Pos	_	_	_	_
13	THP	Thp	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
14	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
15	1	1	NUM	CD	NumType=Card	_	_	_	_
16	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
17	and	and	CCONJ	CC	_	_	_	_	_
18	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
19	umbilical	umbilical	ADJ	JJ	Degree=Pos	_	_	_	_
20	vein	vein	NOUN	NN	Number=Sing	_	_	_	_
21	endothelial	endothelial	ADJ	JJ	Degree=Pos	_	_	_	_
22	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
23	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
24	inhibited	inhibit	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
25	by	by	ADP	IN	_	_	_	_	_
26	elevated	elevate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
27	cAMP	camp	NOUN	NN	Number=Sing	_	_	_	_
28	and	and	CCONJ	CC	_	_	_	_	_
29	by	by	ADP	IN	_	_	_	_	_
30	overexpression	overexpression	NOUN	NN	Number=Sing	_	_	_	_
31	of	of	ADP	IN	_	_	_	_	_
32	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
33	catalytic	catalytic	ADJ	JJ	Degree=Pos	_	_	_	_
34	subunit	subunit	NOUN	NN	Number=Sing	_	_	_	_
35	of	of	ADP	IN	_	_	_	_	_
36	protein	protein	NOUN	NN	Number=Sing	_	_	_	_
37	kinase	kinase	NOUN	NN	Number=Sing	_	_	_	_
38	A	A	PROPN	NNP	Number=Sing	_	_	_	_
39	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
40	PKA	PKA	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
41	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
42	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3814
# text = Elevated cAMP did not prevent nuclear translocation of p50/p65 and c-Rel/p65 heterodimers, decrease nuclear translocation of p65, or significantly modify TNFalpha-induced phosphorylation of p65.
1	Elevated	elevated	PROPN	NNP	Number=Sing	_	_	_	_
2	cAMP	camp	PROPN	NNP	Number=Sing	_	_	_	_
3	did	do	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
4	not	not	PART	RB	_	_	_	_	_
5	prevent	prevent	VERB	VB	VerbForm=Inf	_	_	_	_
6	nuclear	nuclear	ADJ	JJ	Degree=Pos	_	_	_	_
7	translocation	translocation	NOUN	NN	Number=Sing	_	_	_	_
8	of	of	ADP	IN	_	_	_	_	_
9	p50/	p50/	SYM	SYM	_	_	_	_	SpaceAfter=No
10	p65	p65	NUM	CD	NumType=Card	_	_	_	_
11	and	and	CCONJ	CC	_	_	_	_	_
12	c-	c-	SYM	NFP	_	_	_	_	SpaceAfter=No
13	Rel	Rel	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
14	/	/	PUNCT	,	_	_	_	_	SpaceAfter=No
15	p65	p65	NOUN	NN	Number=Sing	_	_	_	_
16	heterodimers	heterodimer	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
17	,	,	PUNCT	,	_	_	_	_	_
18	decrease	decrease	NOUN	NN	Number=Sing	_	_	_	_
19	nuclear	nuclear	ADJ	JJ	Degree=Pos	_	_	_	_
20	translocation	translocation	NOUN	NN	Number=Sing	_	_	_	_
21	of	of	ADP	IN	_	_	_	_	_
22	p65	p65	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
23	,	,	PUNCT	,	_	_	_	_	_
24	or	or	CCONJ	CC	_	_	_	_	_
25	significantly	significantly	ADV	RB	_	_	_	_	_
26	modify	modify	VERB	VB	VerbForm=Inf	_	_	_	_
27	TNFalpha	TNFalpha	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
28	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
29	induced	induce	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
30	phosphorylation	phosphorylation	NOUN	NN	Number=Sing	_	_	_	_
31	of	of	ADP	IN	_	_	_	_	_
32	p65	p65	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
33	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3815
# text = Functional studies demonstrated that transcriptional activation of a plasmid containing multimerized kappaB sites by p65 was inhibited by agents that elevate cAMP and by overexpression of the catalytic subunit of PKA.
1	Functional	functional	ADJ	JJ	Degree=Pos	_	_	_	_
2	studies	study	NOUN	NNS	Number=Plur	_	_	_	_
3	demonstrated	demonstrate	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
4	that	that	SCONJ	IN	_	_	_	_	_
5	transcriptional	transcriptional	ADJ	JJ	Degree=Pos	_	_	_	_
6	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
7	of	of	ADP	IN	_	_	_	_	_
8	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
9	plasmid	plasmid	NOUN	NN	Number=Sing	_	_	_	_
10	containing	contain	VERB	VBG	VerbForm=Ger	_	_	_	_
11	multimerized	multimerize	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
12	kappaB	kappaB	NOUN	NN	Number=Sing	_	_	_	_
13	sites	site	NOUN	NNS	Number=Plur	_	_	_	_
14	by	by	ADP	IN	_	_	_	_	_
15	p65	p65	NOUN	NN	Number=Sing	_	_	_	_
16	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
17	inhibited	inhibit	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
18	by	by	ADP	IN	_	_	_	_	_
19	agents	agent	NOUN	NNS	Number=Plur	_	_	_	_
20	that	that	PRON	WDT	PronType=Rel	_	_	_	_
21	elevate	elevate	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
22	cAMP	camp	NOUN	NN	Number=Sing	_	_	_	_
23	and	and	CCONJ	CC	_	_	_	_	_
24	by	by	ADP	IN	_	_	_	_	_
25	overexpression	overexpression	NOUN	NN	Number=Sing	_	_	_	_
26	of	of	ADP	IN	_	_	_	_	_
27	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
28	catalytic	catalytic	ADJ	JJ	Degree=Pos	_	_	_	_
29	subunit	subunit	NOUN	NN	Number=Sing	_	_	_	_
30	of	of	ADP	IN	_	_	_	_	_
31	PKA	PKA	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
32	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3816
# text = This study indicates that activation of PKA reduces the induction of a distinct set of genes in monocytes and endothelial cells by inhibiting NF-kappaB-mediated transcription.
1	This	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
2	study	study	NOUN	NN	Number=Sing	_	_	_	_
3	indicates	indicate	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
4	that	that	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
5	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
6	of	of	ADP	IN	_	_	_	_	_
7	PKA	PKA	PROPN	NNP	Number=Sing	_	_	_	_
8	reduces	reduce	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
9	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
10	induction	induction	NOUN	NN	Number=Sing	_	_	_	_
11	of	of	ADP	IN	_	_	_	_	_
12	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
13	distinct	distinct	ADJ	JJ	Degree=Pos	_	_	_	_
14	set	set	NOUN	NN	Number=Sing	_	_	_	_
15	of	of	ADP	IN	_	_	_	_	_
16	genes	gene	NOUN	NNS	Number=Plur	_	_	_	_
17	in	in	ADP	IN	_	_	_	_	_
18	monocytes	monocyte	NOUN	NNS	Number=Plur	_	_	_	_
19	and	and	CCONJ	CC	_	_	_	_	_
20	endothelial	endothelial	ADJ	JJ	Degree=Pos	_	_	_	_
21	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
22	by	by	SCONJ	IN	_	_	_	_	_
23	inhibiting	inhibit	VERB	VBG	VerbForm=Ger	_	_	_	_
24	NF	NF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
25	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
26	kappaB	kappaB	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
27	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
28	mediated	mediate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
29	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
30	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 3817
# text = Document 003003588 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	003003588	003003588	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 3818
# text = The Epstein-Barr virus (EBV) BMRF1 promoter for early antigen (EA-D) is regulated by the EBV transactivators, BRLF1 and BZLF1, in a cell-specific manner.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	Epstein	Epstein	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
3	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
4	Barr	Barr	PROPN	NNP	Number=Sing	_	_	_	_
5	virus	virus	NOUN	NN	Number=Sing	_	_	_	_
6	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
7	EBV	EBV	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
8	)	)	PUNCT	-RRB-	_	_	_	_	_
9	BMRF1	BMRF1	NUM	CD	NumType=Card	_	_	_	_
10	promoter	promoter	NOUN	NN	Number=Sing	_	_	_	_
11	for	for	ADP	IN	_	_	_	_	_
12	early	early	ADJ	JJ	Degree=Pos	_	_	_	_
13	antigen	antigen	NOUN	NNS	Number=Plur	_	_	_	_
14	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
15	EA	Ea	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
16	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
17	D	d	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
18	)	)	PUNCT	-RRB-	_	_	_	_	_
19	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
20	regulated	regulate	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
21	by	by	ADP	IN	_	_	_	_	_
22	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
23	EBV	EBV	PROPN	NNP	Number=Sing	_	_	_	_
24	transactivators	transactivator	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
25	,	,	PUNCT	,	_	_	_	_	_
26	BRLF1	BRLF1	PROPN	NNP	Number=Sing	_	_	_	_
27	and	and	CCONJ	CC	_	_	_	_	_
28	BZLF1	BZLF1	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
29	,	,	PUNCT	,	_	_	_	_	_
30	in	in	ADP	IN	_	_	_	_	_
31	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
32	cell	cell	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
33	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
34	specific	specific	ADJ	JJ	Degree=Pos	_	_	_	_
35	manner	manner	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
36	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 3819
# text = The Epstein-Barr virus early antigen diffuse component (EA-D) is essential for Epstein-Barr virus DNA polymerase activity, and its activity is suppressed during latent infection.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	Epstein	Epstein	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
3	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
4	Barr	Barr	PROPN	NNP	Number=Sing	_	_	_	_
5	virus	virus	NOUN	NN	Number=Sing	_	_	_	_
6	early	early	ADJ	JJ	Degree=Pos	_	_	_	_
7	antigen	antigen	ADJ	JJ	Degree=Pos	_	_	_	_
8	diffuse	diffuse	NOUN	NN	Number=Sing	_	_	_	_
9	component	component	NOUN	NN	Number=Sing	_	_	_	_
10	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
11	EA	Ea	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
12	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
13	D	d	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
14	)	)	PUNCT	-RRB-	_	_	_	_	_
15	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
16	essential	essential	ADJ	JJ	Degree=Pos	_	_	_	_
17	for	for	ADP	IN	_	_	_	_	_
18	Epstein	Epstein	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
19	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
20	Barr	Barr	PROPN	NNP	Number=Sing	_	_	_	_
21	virus	virus	NOUN	NN	Number=Sing	_	_	_	_
22	DNA	dna	NOUN	NN	Number=Sing	_	_	_	_
23	polymerase	polymerase	NOUN	NN	Number=Sing	_	_	_	_
24	activity	activity	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
25	,	,	PUNCT	,	_	_	_	_	_
26	and	and	CCONJ	CC	_	_	_	_	_
27	it	it	PRON	PRP	Case=Nom|Gender=Neut|Number=Sing|Person=3|PronType=Prs	_	_	_	SpaceAfter=No
28	s	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
29	activity	activity	NOUN	NN	Number=Sing	_	_	_	_
30	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
31	suppressed	suppress	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
32	during	during	ADP	IN	_	_	_	_	_
33	latent	latent	ADJ	JJ	Degree=Pos	_	_	_	_
34	infection	infection	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
35	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3820
# text = We investigated the regulation of the promoter (BMRF1) for this early gene by studying its responsiveness in vitro to two immediate-early viral transactivators, BZLF1 (Z) and BRLF1 (R), focusing on the differences in response in lymphoid cells and epithelial cells.
1	We	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
2	investigated	investigate	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
3	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
4	regulation	regulation	NOUN	NN	Number=Sing	_	_	_	_
5	of	of	ADP	IN	_	_	_	_	_
6	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
7	promoter	promoter	NOUN	NN	Number=Sing	_	_	_	_
8	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
9	BMRF1	BMRF1	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
10	)	)	PUNCT	-RRB-	_	_	_	_	_
11	for	for	ADP	IN	_	_	_	_	_
12	this	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
13	early	early	ADJ	JJ	Degree=Pos	_	_	_	_
14	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
15	by	by	SCONJ	IN	_	_	_	_	_
16	studying	study	VERB	VBG	VerbForm=Ger	_	_	_	_
17	its	its	PRON	PRP$	Gender=Neut|Number=Sing|Person=3|Poss=Yes|PronType=Prs	_	_	_	_
18	responsiveness	responsiveness	NOUN	NN	Number=Sing	_	_	_	_
19	in	in	ADP	IN	_	_	_	_	_
20	vitro	vitro	NUM	CD	NumType=Card	_	_	_	_
21	to	to	ADP	IN	_	_	_	_	_
22	two	two	NUM	CD	NumType=Card	_	_	_	_
23	immediate	immediate	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
24	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
25	early	early	ADJ	JJ	Degree=Pos	_	_	_	_
26	viral	viral	ADJ	JJ	Degree=Pos	_	_	_	_
27	transactivators	transactivator	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
28	,	,	PUNCT	,	_	_	_	_	_
29	BZLF	BZLF	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
30	1	1	NUM	CD	NumType=Card	_	_	_	_
31	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
32	Z	Z	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
33	)	)	PUNCT	-RRB-	_	_	_	_	_
34	and	and	CCONJ	CC	_	_	_	_	_
35	BRLF1	BRLF1	PROPN	NNP	Number=Sing	_	_	_	_
36	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
37	R	R	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
38	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
39	,	,	PUNCT	,	_	_	_	_	_
40	focusing	focus	VERB	VBG	VerbForm=Ger	_	_	_	_
41	on	on	ADP	IN	_	_	_	_	_
42	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
43	differences	difference	NOUN	NNS	Number=Plur	_	_	_	_
44	in	in	ADP	IN	_	_	_	_	_
45	response	response	NOUN	NN	Number=Sing	_	_	_	_
46	in	in	ADP	IN	_	_	_	_	_
47	lymphoid	lymphoid	ADJ	JJ	Degree=Pos	_	_	_	_
48	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
49	and	and	CCONJ	CC	_	_	_	_	_
50	epithelial	epithelial	ADJ	JJ	Degree=Pos	_	_	_	_
51	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
52	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3821
# text = In lymphoid cells, Z or R alone produced only small increases in EA-D promoter activity, whereas both transactivators together produced a large stimulatory effect.
1	In	in	ADP	IN	_	_	_	_	_
2	lymphoid	lymphoid	ADJ	JJ	Degree=Pos	_	_	_	_
3	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	,	,	PUNCT	,	_	_	_	_	_
5	Z	Z	PROPN	NNP	Number=Sing	_	_	_	_
6	or	or	CCONJ	CC	_	_	_	_	_
7	R	be	PROPN	NNP	Number=Sing	_	_	_	_
8	alone	alone	ADV	RB	_	_	_	_	_
9	produced	produce	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
10	only	only	ADV	RB	_	_	_	_	_
11	small	small	ADJ	JJ	Degree=Pos	_	_	_	_
12	increases	increase	NOUN	NNS	Number=Plur	_	_	_	_
13	in	in	ADP	IN	_	_	_	_	_
14	EA	EA	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
15	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
16	D	D	PROPN	NNP	Number=Sing	_	_	_	_
17	promoter	promoter	NOUN	NN	Number=Sing	_	_	_	_
18	activity	activity	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
19	,	,	PUNCT	,	_	_	_	_	_
20	whereas	whereas	SCONJ	IN	_	_	_	_	_
21	both	both	DET	DT	_	_	_	_	_
22	transactivators	transactivator	NOUN	NNS	Number=Plur	_	_	_	_
23	together	together	ADV	RB	_	_	_	_	_
24	produced	produce	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
25	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
26	large	large	ADJ	JJ	Degree=Pos	_	_	_	_
27	stimulatory	stimulatory	ADJ	JJ	Degree=Pos	_	_	_	_
28	effect	effect	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
29	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3822
# text = In epithelial cells, the Z transactivator alone produced maximal stimulation of the EA-D promoter; the effect of R and Z together was no greater than that of Z alone.
1	In	in	ADP	IN	_	_	_	_	_
2	epithelial	epithelial	ADJ	JJ	Degree=Pos	_	_	_	_
3	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	,	,	PUNCT	,	_	_	_	_	_
5	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
6	Z	Z	PROPN	NNP	Number=Sing	_	_	_	_
7	transactivator	transactivator	NOUN	NN	Number=Sing	_	_	_	_
8	alone	alone	ADV	RB	_	_	_	_	_
9	produced	produce	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
10	maximal	maximal	ADJ	JJ	Degree=Pos	_	_	_	_
11	stimulation	stimulation	NOUN	NN	Number=Sing	_	_	_	_
12	of	of	ADP	IN	_	_	_	_	_
13	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
14	EA	EA	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
15	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
16	D	D	PROPN	NNP	Number=Sing	_	_	_	_
17	promoter	promoter	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
18	;	;	PUNCT	,	_	_	_	_	_
19	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
20	effect	effect	NOUN	NN	Number=Sing	_	_	_	_
21	of	of	ADP	IN	_	_	_	_	_
22	R	R	PROPN	NNP	Number=Sing	_	_	_	_
23	and	and	CCONJ	CC	_	_	_	_	_
24	Z	Z	PROPN	NNP	Number=Sing	_	_	_	_
25	together	together	ADV	RB	_	_	_	_	_
26	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
27	no	no	ADV	RB	_	_	_	_	_
28	greater	greater	ADJ	JJR	Degree=Cmp	_	_	_	_
29	than	than	ADP	IN	_	_	_	_	_
30	that	that	PRON	DT	Number=Sing|PronType=Dem	_	_	_	_
31	of	of	ADP	IN	_	_	_	_	_
32	Z	Z	PROPN	NNP	Number=Sing	_	_	_	_
33	alone	alone	ADV	RB	_	_	_	_	SpaceAfter=No
34	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3823
# text = Deletional analysis and site-directed mutagenesis of the EA-D promoter demonstrated that in epithelial cells the potential AP-1 binding site plays an essential role in Z responsiveness, although sequences further upstream are also important.
1	Deletional	Deletional	ADJ	JJ	Degree=Pos	_	_	_	_
2	analysis	analysis	NOUN	NN	Number=Sing	_	_	_	_
3	and	and	CCONJ	CC	_	_	_	_	_
4	site	site	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
5	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
6	directed	direct	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
7	mutagenesis	mutagenesis	NOUN	NN	Number=Sing	_	_	_	_
8	of	of	ADP	IN	_	_	_	_	_
9	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
10	EA	Ea	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
11	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
12	D	d	PROPN	NNP	Number=Sing	_	_	_	_
13	promoter	promoter	NOUN	NN	Number=Sing	_	_	_	_
14	demonstrated	demonstrate	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
15	that	that	PRON	DT	Number=Sing|PronType=Dem	_	_	_	_
16	in	in	ADP	IN	_	_	_	_	_
17	epithelial	epithelial	ADJ	JJ	Degree=Pos	_	_	_	_
18	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
19	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
20	potential	potential	ADJ	JJ	Degree=Pos	_	_	_	_
21	AP	ap	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
22	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
23	1	1	NUM	CD	NumType=Card	_	_	_	_
24	binding	binding	VERB	VBG	VerbForm=Ger	_	_	_	_
25	site	site	NOUN	NN	Number=Sing	_	_	_	_
26	plays	play	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
27	an	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
28	essential	essential	ADJ	JJ	Degree=Pos	_	_	_	_
29	role	role	NOUN	NN	Number=Sing	_	_	_	_
30	in	in	ADP	IN	_	_	_	_	_
31	Z	Z	PROPN	NNP	Number=Sing	_	_	_	_
32	responsiveness	responsiveness	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
33	,	,	PUNCT	,	_	_	_	_	_
34	although	although	SCONJ	IN	_	_	_	_	_
35	sequences	sequence	NOUN	NNS	Number=Plur	_	_	_	_
36	further	further	ADV	RB	_	_	_	_	_
37	upstream	upstream	ADJ	JJ	Degree=Pos	_	_	_	_
38	are	be	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
39	also	also	ADV	RB	_	_	_	_	_
40	important	important	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
41	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3824
# text = In lymphoid cells, only the upstream sequences are required for transactivation by the Z/R combination, and the AP-1 site is dispensable.
1	In	in	ADP	IN	_	_	_	_	_
2	lymphoid	lymphoid	ADJ	JJ	Degree=Pos	_	_	_	_
3	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	,	,	PUNCT	,	_	_	_	_	_
5	only	only	ADV	RB	_	_	_	_	_
6	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
7	upstream	upstream	ADJ	JJ	Degree=Pos	_	_	_	_
8	sequences	sequence	NOUN	NNS	Number=Plur	_	_	_	_
9	are	be	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
10	required	require	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
11	for	for	ADP	IN	_	_	_	_	_
12	transactivation	transactivation	NOUN	NN	Number=Sing	_	_	_	_
13	by	by	ADP	IN	_	_	_	_	_
14	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
15	Z/R	Z/R	PROPN	NNP	Number=Sing	_	_	_	_
16	combination	combination	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
17	,	,	PUNCT	,	_	_	_	_	_
18	and	and	CCONJ	CC	_	_	_	_	_
19	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
20	AP	ap	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
21	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
22	1	1	NUM	CD	NumType=Card	_	_	_	_
23	site	site	NOUN	NN	Number=Sing	_	_	_	_
24	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
25	dispensable	dispensable	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
26	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3825
# text = These data suggest that EA-D (BMRF1) promoter regulation by Z and R is cell type specific and appears to involve different mechanisms in each cell type.
1	These	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
2	data	data	NOUN	NN	Number=Sing	_	_	_	_
3	suggest	suggest	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
4	that	that	SCONJ	IN	_	_	_	_	_
5	EA	Ea	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
6	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
7	D	d	PROPN	NNP	Number=Sing	_	_	_	_
8	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
9	BMRF1	BMRF1	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
10	)	)	PUNCT	-RRB-	_	_	_	_	_
11	promoter	promoter	NOUN	NN	Number=Sing	_	_	_	_
12	regulation	regulation	NOUN	NN	Number=Sing	_	_	_	_
13	by	by	ADP	IN	_	_	_	_	_
14	Z	Z	PROPN	NNP	Number=Sing	_	_	_	_
15	and	and	CCONJ	CC	_	_	_	_	_
16	R	R	PROPN	NNP	Number=Sing	_	_	_	_
17	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
18	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
19	type	type	NOUN	NN	Number=Sing	_	_	_	_
20	specific	specific	ADJ	JJ	Degree=Pos	_	_	_	_
21	and	and	CCONJ	CC	_	_	_	_	_
22	appears	appear	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
23	to	to	PART	TO	_	_	_	_	_
24	involve	involve	VERB	VB	VerbForm=Inf	_	_	_	_
25	different	different	ADJ	JJ	Degree=Pos	_	_	_	_
26	mechanisms	mechanism	NOUN	NNS	Number=Plur	_	_	_	_
27	in	in	ADP	IN	_	_	_	_	_
28	each	each	DET	DT	_	_	_	_	_
29	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
30	type	type	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
31	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 3826
# text = Document 003003589 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	003003589	003003589	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 3827
# text = Bcl-6 expression in reactive follicular hyperplasia, follicular lymphoma, and angioimmunoblastic T-cell lymphoma with hyperplastic germinal centers: heterogeneity of intrafollicular T-cells and their altered distribution in the pathogenesis of angioimmunoblastic T-cell lymphoma.
1	Bcl	Bcl	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
2	-6	-6	NUM	CD	NumType=Card	_	_	_	_
3	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
4	in	in	ADP	IN	_	_	_	_	_
5	reactive	reactive	ADJ	JJ	Degree=Pos	_	_	_	_
6	follicular	follicular	ADJ	JJ	Degree=Pos	_	_	_	_
7	hyperplasia	hyperplasia	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
8	,	,	PUNCT	,	_	_	_	_	_
9	follicular	follicular	ADJ	JJ	Degree=Pos	_	_	_	_
10	lymphoma	lymphoma	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
11	,	,	PUNCT	,	_	_	_	_	_
12	and	and	CCONJ	CC	_	_	_	_	_
13	angioimmunoblastic	angioimmunoblastic	ADJ	JJ	Degree=Pos	_	_	_	_
14	T-	t-	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
15	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
16	lymphoma	lymphoma	NOUN	NN	Number=Sing	_	_	_	_
17	with	with	ADP	IN	_	_	_	_	_
18	hyperplastic	hyperplastic	ADJ	JJ	Degree=Pos	_	_	_	_
19	germinal	germinal	ADJ	JJ	Degree=Pos	_	_	_	_
20	centers	center	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
21	:	:	PUNCT	:	_	_	_	_	_
22	heterogeneity	heterogeneity	NOUN	NN	Number=Sing	_	_	_	_
23	of	of	ADP	IN	_	_	_	_	_
24	intrafollicular	intrafollicular	ADJ	JJ	Degree=Pos	_	_	_	_
25	T-	t-	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
26	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
27	and	and	CCONJ	CC	_	_	_	_	_
28	their	they	PRON	PRP$	Number=Plur|Person=3|Poss=Yes|PronType=Prs	_	_	_	_
29	altered	alter	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
30	distribution	distribution	NOUN	NN	Number=Sing	_	_	_	_
31	in	in	ADP	IN	_	_	_	_	_
32	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
33	pathogenesis	pathogenesis	NOUN	NN	Number=Sing	_	_	_	_
34	of	of	ADP	IN	_	_	_	_	_
35	angioimmunoblastic	angioimmunoblastic	ADJ	JJ	Degree=Pos	_	_	_	_
36	T-	t-	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
37	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
38	lymphoma	lymphoma	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
39	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 3828
# text = BACKGROUND: The Bcl-6 gene product, a nuclear phosphoprotein, is expressed independently of Bcl-6 gene rearrangement.
1	BACKGROUND	background	ADP	IN	_	_	_	_	SpaceAfter=No
2	:	:	PUNCT	:	_	_	_	_	_
3	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
4	Bcl	Bcl	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
5	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
6	6	6	NUM	CD	NumType=Card	_	_	_	_
7	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
8	product	product	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
9	,	,	PUNCT	,	_	_	_	_	_
10	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
11	nuclear	nuclear	ADJ	JJ	Degree=Pos	_	_	_	_
12	phosphoprotein	phosphoprotein	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
13	,	,	PUNCT	,	_	_	_	_	_
14	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
15	expressed	express	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
16	independently	independently	ADV	RB	_	_	_	_	_
17	of	of	ADP	IN	_	_	_	_	_
18	Bcl	Bcl	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
19	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
20	6	6	NUM	CD	NumType=Card	_	_	_	_
21	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
22	rearrangement	rearrangement	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
23	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3829
# text = In lymph nodes, expression of Bcl-6 protein is restricted to germinal center (GC) B-cells and 10% to 15% of CD3/CD4+ intrafollicular
1	In	in	ADP	IN	_	_	_	_	_
2	lymph	lymph	ADJ	JJ	Degree=Pos	_	_	_	_
3	nodes	node	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	,	,	PUNCT	,	_	_	_	_	_
5	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
6	of	of	ADP	IN	_	_	_	_	_
7	Bcl	Bcl	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
8	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
9	6	6	NUM	CD	NumType=Card	_	_	_	_
10	protein	protein	NOUN	NN	Number=Sing	_	_	_	_
11	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
12	restricted	restrict	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
13	to	to	PART	TO	_	_	_	_	_
14	germinal	germinal	VERB	VB	VerbForm=Inf	_	_	_	_
15	center	center	NOUN	NN	Number=Sing	_	_	_	_
16	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
17	GC	GC	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
18	)	)	PUNCT	-RRB-	_	_	_	_	_
19	B	b	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
20	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
21	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
22	and	and	CCONJ	CC	_	_	_	_	_
23	10	10	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
24	%	%	SYM	NN	Number=Sing	_	_	_	_
25	to	to	ADP	IN	_	_	_	_	_
26	15	15	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
27	%	%	SYM	NN	Number=Sing	_	_	_	_
28	of	of	ADP	IN	_	_	_	_	_
29	CD3/CD4	CD3/CD4	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
30	+	+	SYM	SYM	_	_	_	_	_
31	intrafollicular	intrafollicular	ADJ	JJ	Degree=Pos	_	_	_	_

# sent_id = 3830
# text = T cells.
1	T	t	PROPN	NNP	Number=Sing	_	_	_	_
2	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
3	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3831
# text = Interfollicular cells are negative for Bcl-6 protein, except for rare CD3+/CD4+ T cells.
1	Interfollicular	Interfollicular	ADJ	JJ	Degree=Pos	_	_	_	_
2	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
3	are	be	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
4	negative	negative	ADJ	JJ	Degree=Pos	_	_	_	_
5	for	for	ADP	IN	_	_	_	_	_
6	Bcl	Bcl	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
7	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
8	6	6	NUM	CD	NumType=Card	_	_	_	_
9	protein	protein	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
10	,	,	PUNCT	,	_	_	_	_	_
11	except	except	ADP	IN	_	_	_	_	_
12	for	for	ADP	IN	_	_	_	_	_
13	rare	rare	ADJ	JJ	Degree=Pos	_	_	_	_
14	CD3+/CD4	CD3+/CD4	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
15	+	+	SYM	SYM	_	_	_	_	_
16	T	t	NUM	CD	NumType=Card	_	_	_	_
17	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
18	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3832
# text = Recently, we reported cases of angioimmunoblastic T-cell lymphoma (AITL) with hyperplastic GCs (AITL/GC), and observed that borders of enlarged GCs were ill defined, with features suggestive of an outward migration of GC cells to surrounding interfollicular zones.
1	Recently	recently	ADV	RB	_	_	_	_	SpaceAfter=No
2	,	,	PUNCT	,	_	_	_	_	_
3	we	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
4	reported	report	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
5	cases	casis	NOUN	NNS	Number=Plur	_	_	_	_
6	of	of	ADP	IN	_	_	_	_	_
7	angioimmunoblastic	angioimmunoblastic	ADJ	JJ	Degree=Pos	_	_	_	_
8	T-	t-	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
9	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
10	lymphoma	lymphoma	NOUN	NN	Number=Sing	_	_	_	_
11	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
12	AITL	AITL	INTJ	UH	_	_	_	_	SpaceAfter=No
13	)	)	PUNCT	-RRB-	_	_	_	_	_
14	with	with	ADP	IN	_	_	_	_	_
15	hyperplastic	hyperplastic	ADJ	JJ	Degree=Pos	_	_	_	_
16	GCs	GC	NOUN	NNS	Number=Plur	_	_	_	_
17	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
18	AITL/	AITL/	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
19	GC	GC	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
20	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
21	,	,	PUNCT	,	_	_	_	_	_
22	and	and	CCONJ	CC	_	_	_	_	_
23	observed	observe	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
24	that	that	SCONJ	IN	_	_	_	_	_
25	borders	border	NOUN	NNS	Number=Plur	_	_	_	_
26	of	of	ADP	IN	_	_	_	_	_
27	enlarged	enlarge	ADJ	JJ	Degree=Pos	_	_	_	_
28	GCs	Gcs	NOUN	NNS	Number=Plur	_	_	_	_
29	were	be	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
30	ill	ill	ADV	RB	_	_	_	_	_
31	defined	define	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	SpaceAfter=No
32	,	,	PUNCT	,	_	_	_	_	_
33	with	with	SCONJ	IN	_	_	_	_	_
34	features	feature	NOUN	NNS	Number=Plur	_	_	_	_
35	suggestive	suggestive	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
36	of	of	ADP	IN	_	_	_	_	_
37	an	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
38	outward	outward	ADJ	JJ	Degree=Pos	_	_	_	_
39	migration	migration	NOUN	NN	Number=Sing	_	_	_	_
40	of	of	ADP	IN	_	_	_	_	_
41	GC	Gc	PROPN	NNP	Number=Sing	_	_	_	_
42	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
43	to	to	SCONJ	IN	_	_	_	_	_
44	surrounding	surround	VERB	VBG	VerbForm=Ger	_	_	_	_
45	interfollicular	interfollicular	ADJ	JJ	Degree=Pos	_	_	_	_
46	zones	zone	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
47	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3833
# text = This prompted a study of follicular borders with Bcl-6 staining in reactive follicular hyperplasias and follicular lymphomas to compare with AITL/GC.
1	This	this	PRON	DT	Number=Sing|PronType=Dem	_	_	_	_
2	prompted	prompt	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
3	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
4	study	study	NOUN	NN	Number=Sing	_	_	_	_
5	of	of	ADP	IN	_	_	_	_	_
6	follicular	follicular	ADJ	JJ	Degree=Pos	_	_	_	_
7	borders	border	NOUN	NNS	Number=Plur	_	_	_	_
8	with	with	ADP	IN	_	_	_	_	_
9	Bcl	Bcl	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
10	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
11	6	6	NUM	CD	NumType=Card	_	_	_	_
12	staining	staining	VERB	VBG	VerbForm=Ger	_	_	_	_
13	in	in	ADP	IN	_	_	_	_	_
14	reactive	reactive	ADJ	JJ	Degree=Pos	_	_	_	_
15	follicular	follicular	ADJ	JJ	Degree=Pos	_	_	_	_
16	hyperplasias	hyperplasia	NOUN	NNS	Number=Plur	_	_	_	_
17	and	and	CCONJ	CC	_	_	_	_	_
18	follicular	follicular	ADJ	JJ	Degree=Pos	_	_	_	_
19	lymphomas	lymphoma	NOUN	NNS	Number=Plur	_	_	_	_
20	to	to	PART	TO	_	_	_	_	_
21	compare	compare	VERB	VB	VerbForm=Inf	_	_	_	_
22	with	with	ADP	IN	_	_	_	_	_
23	AITL	AITL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
24	/	/	PUNCT	,	_	_	_	_	SpaceAfter=No
25	GC	GC	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
26	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3834
# text = MATERIALS AND METHODS: Formalin-fixed paraffin sections were used for immunostaining of Bcl-6.
1	MATERIALS	material	NOUN	NNS	Number=Plur	_	_	_	_
2	AND	and	CCONJ	CC	_	_	_	_	_
3	METHODS	method	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	:	:	PUNCT	:	_	_	_	_	_
5	Formalin	Formalin	ADP	IN	_	_	_	_	SpaceAfter=No
6	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
7	fixed	fix	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
8	paraffin	paraffin	NOUN	NN	Number=Sing	_	_	_	_
9	sections	section	NOUN	NNS	Number=Plur	_	_	_	_
10	were	be	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
11	used	use	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
12	for	for	SCONJ	IN	_	_	_	_	_
13	immunostaining	immunostaining	VERB	VBG	VerbForm=Ger	_	_	_	_
14	of	of	ADP	IN	_	_	_	_	_
15	Bcl	Bcl	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
16	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
17	6	6	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
18	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3835
# text = Six cases of AITL/GC, 12 nonspecific reactive follicular hyperplasia (FH), 7 HIV adenopathy, 10 follicular lymphoma (FL), and 8 typical AITL (ie, AITL without GC) were studied.
1	Six	six	NUM	CD	NumType=Card	_	_	_	_
2	cases	case	NOUN	NNS	Number=Plur	_	_	_	_
3	of	of	ADP	IN	_	_	_	_	_
4	AITL/GC	AITL/GC	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
5	,	,	PUNCT	,	_	_	_	_	_
6	12	12	NUM	CD	NumType=Card	_	_	_	_
7	nonspecific	nonspecific	ADJ	JJ	Degree=Pos	_	_	_	_
8	reactive	reactive	ADJ	JJ	Degree=Pos	_	_	_	_
9	follicular	follicular	ADJ	JJ	Degree=Pos	_	_	_	_
10	hyperplasia	hyperplasia	NOUN	NN	Number=Sing	_	_	_	_
11	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
12	FH	FH	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
13	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
14	,	,	PUNCT	,	_	_	_	_	_
15	7	7	NUM	CD	NumType=Card	_	_	_	_
16	HIV	Hiv	NOUN	NN	Number=Sing	_	_	_	_
17	adenopathy	adenopathy	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
18	,	,	PUNCT	,	_	_	_	_	_
19	10	10	NUM	CD	NumType=Card	_	_	_	_
20	follicular	follicular	ADJ	JJ	Degree=Pos	_	_	_	_
21	lymphoma	lymphoma	NOUN	NN	Number=Sing	_	_	_	_
22	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
23	FL	FL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
24	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
25	,	,	PUNCT	,	_	_	_	_	_
26	and	and	CCONJ	CC	_	_	_	_	_
27	8	8	NUM	CD	NumType=Card	_	_	_	_
28	typical	typical	ADJ	JJ	Degree=Pos	_	_	_	_
29	AITL	Aitl	NOUN	NN	Number=Sing	_	_	_	_
30	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
31	ie	ie	X	FW	_	_	_	_	SpaceAfter=No
32	,	,	PUNCT	,	_	_	_	_	_
33	AITL	AITL	ADV	RB	_	_	_	_	_
34	without	without	ADP	IN	_	_	_	_	_
35	GC	GC	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
36	)	)	PUNCT	-RRB-	_	_	_	_	_
37	were	be	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
38	studied	study	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	SpaceAfter=No
39	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3836
# text = Double staining for Bcl-6/CD20, Bcl-6/CD3, and Bcl-6/CD57 was performed in selected cases.
1	Double	double	ADJ	JJ	Degree=Pos	_	_	_	_
2	staining	stai	VERB	VBG	VerbForm=Ger	_	_	_	_
3	for	for	ADP	IN	_	_	_	_	_
4	Bcl-6/CD20	Bcl-6/CD20	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
5	,	,	PUNCT	,	_	_	_	_	_
6	Bcl-6/CD3	Bcl-6/CD3	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
7	,	,	PUNCT	,	_	_	_	_	_
8	and	and	CCONJ	CC	_	_	_	_	_
9	Bcl-6/CD57	Bcl-6/CD57	NOUN	NN	Number=Sing	_	_	_	_
10	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
11	performed	perform	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
12	in	in	ADP	IN	_	_	_	_	_
13	selected	select	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
14	cases	casis	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
15	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3837
# text = RESULTS: In FH and HIV adenopathy, staining for Bcl-6 revealed densely populated GCs with well-defined and regular GC borders, whereas Bcl-6+ cells were rare in the interfollicular areas.
1	RESULTS	result	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
2	:	:	PUNCT	:	_	_	_	_	_
3	In	in	ADP	IN	_	_	_	_	_
4	FH	FH	PROPN	NNP	Number=Sing	_	_	_	_
5	and	and	CCONJ	CC	_	_	_	_	_
6	HIV	HIV	PROPN	NNP	Number=Sing	_	_	_	_
7	adenopathy	adenopathy	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
8	,	,	PUNCT	,	_	_	_	_	_
9	staining	stain	VERB	VBG	VerbForm=Ger	_	_	_	_
10	for	for	ADP	IN	_	_	_	_	_
11	Bcl	Bcl	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
12	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
13	6	6	NUM	CD	NumType=Card	_	_	_	_
14	revealed	reveal	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
15	densely	densely	ADV	RB	_	_	_	_	_
16	populated	populate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
17	GCs	GC	NOUN	NNS	Number=Plur	_	_	_	_
18	with	with	ADP	IN	_	_	_	_	_
19	well	well	ADV	RB	Degree=Pos	_	_	_	SpaceAfter=No
20	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
21	defined	define	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
22	and	and	CCONJ	CC	_	_	_	_	_
23	regular	regular	ADJ	JJ	Degree=Pos	_	_	_	_
24	GC	Gc	NOUN	NN	Number=Sing	_	_	_	_
25	borders	border	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
26	,	,	PUNCT	,	_	_	_	_	_
27	whereas	whereas	SCONJ	IN	_	_	_	_	_
28	Bcl	Bcl	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
29	-	-	SYM	SYM	_	_	_	_	SpaceAfter=No
30	6	6	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
31	+	+	SYM	SYM	_	_	_	_	_
32	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
33	were	be	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
34	rare	rare	ADJ	JJ	Degree=Pos	_	_	_	_
35	in	in	ADP	IN	_	_	_	_	_
36	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
37	interfollicular	interfollicular	ADJ	JJ	Degree=Pos	_	_	_	_
38	areas	area	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
39	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3838
# text = An occasional GC with an ill-defined border was invariably surrounded by a broad mantle zone; those with indistinct mantle zones had well-defined, regular borders.
1	An	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
2	occasional	occasional	ADJ	JJ	Degree=Pos	_	_	_	_
3	GC	Gc	NOUN	NN	Number=Sing	_	_	_	_
4	with	with	ADP	IN	_	_	_	_	_
5	an	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
6	ill	ill	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
7	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
8	defined	define	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
9	border	border	NOUN	NN	Number=Sing	_	_	_	_
10	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
11	invariably	invariably	ADV	RB	_	_	_	_	_
12	surrounded	surround	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
13	by	by	ADP	IN	_	_	_	_	_
14	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
15	broad	broad	ADJ	JJ	Degree=Pos	_	_	_	_
16	mantle	mantle	NOUN	NN	Number=Sing	_	_	_	_
17	zone	zone	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
18	;	;	PUNCT	,	_	_	_	_	_
19	those	those	PRON	DT	Number=Plur|PronType=Dem	_	_	_	_
20	with	with	ADP	IN	_	_	_	_	_
21	indistinct	indistinct	ADJ	JJ	Degree=Pos	_	_	_	_
22	mantle	mantle	NOUN	NN	Number=Sing	_	_	_	_
23	zones	zone	NOUN	NNS	Number=Plur	_	_	_	_
24	had	have	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
25	well	well	ADV	RB	Degree=Pos	_	_	_	SpaceAfter=No
26	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
27	defined	define	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	SpaceAfter=No
28	,	,	PUNCT	,	_	_	_	_	_
29	regular	regular	ADJ	JJ	Degree=Pos	_	_	_	_
30	borders	border	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
31	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3839
# text = In FL, follicles were densely populated, and their borders were irregular, with some Bcl-6+ cells in the interfollicular zones.
1	In	in	ADP	IN	_	_	_	_	_
2	FL	FL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
3	,	,	PUNCT	,	_	_	_	_	_
4	follicles	follicle	NOUN	NNS	Number=Plur	_	_	_	_
5	were	be	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
6	densely	densely	ADV	RB	_	_	_	_	_
7	populated	populate	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	SpaceAfter=No
8	,	,	PUNCT	,	_	_	_	_	_
9	and	and	CCONJ	CC	_	_	_	_	_
10	their	they	PRON	PRP$	Number=Plur|Person=3|Poss=Yes|PronType=Prs	_	_	_	_
11	borders	border	NOUN	NNS	Number=Plur	_	_	_	_
12	were	be	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
13	irregular	irregular	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
14	,	,	PUNCT	,	_	_	_	_	_
15	with	with	ADP	IN	_	_	_	_	_
16	some	some	DET	DT	_	_	_	_	_
17	Bcl	Bcl	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
18	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
19	6	6	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
20	+	+	SYM	SYM	_	_	_	_	_
21	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
22	in	in	ADP	IN	_	_	_	_	_
23	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
24	interfollicular	interfollicular	ADJ	JJ	Degree=Pos	_	_	_	_
25	zones	zone	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
26	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3840
# text = In AITL/GC, GCs were less dense, GC borders were ill defined and irregular, and the number of interfollicular Bcl-6+ cells was markedly increased.
1	In	in	ADP	IN	_	_	_	_	_
2	AITL/GC	AITL/GC	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
3	,	,	PUNCT	,	_	_	_	_	_
4	GCs	Gcs	PROPN	NNP	Number=Sing	_	_	_	_
5	were	be	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
6	less	less	ADV	RBR	Degree=Cmp	_	_	_	_
7	dense	dense	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
8	,	,	PUNCT	,	_	_	_	_	_
9	GC	Gc	ADJ	JJ	Degree=Pos	_	_	_	_
10	borders	border	NOUN	NNS	Number=Plur	_	_	_	_
11	were	be	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
12	ill	ill	AUX	MD	VerbForm=Fin	_	_	_	_
13	defined	define	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
14	and	and	CCONJ	CC	_	_	_	_	_
15	irregular	irregular	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
16	,	,	PUNCT	,	_	_	_	_	_
17	and	and	CCONJ	CC	_	_	_	_	_
18	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
19	number	number	NOUN	NN	Number=Sing	_	_	_	_
20	of	of	ADP	IN	_	_	_	_	_
21	interfollicular	interfollicular	ADJ	JJ	Degree=Pos	_	_	_	_
22	Bcl	Bcl	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
23	-	-	SYM	SYM	_	_	_	_	SpaceAfter=No
24	6	6	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
25	+	+	SYM	SYM	_	_	_	_	_
26	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
27	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
28	markedly	markedly	ADV	RB	_	_	_	_	_
29	increased	increase	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	SpaceAfter=No
30	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3841
# text = Double staining revealed that these interfollicular Bcl-6+ cells in AITL/GC were Bcl6+/CD3+/CD20-/CD57-
1	Double	double	ADJ	JJ	Degree=Pos	_	_	_	_
2	staining	stai	NOUN	NN	Number=Sing	_	_	_	_
3	revealed	reveal	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
4	that	that	SCONJ	IN	_	_	_	_	_
5	these	these	DET	DT	Number=Plur|PronType=Dem	_	_	_	_
6	interfollicular	interfollicular	ADJ	JJ	Degree=Pos	_	_	_	_
7	Bcl	Bcl	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
8	-	-	SYM	SYM	_	_	_	_	SpaceAfter=No
9	6	6	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
10	+	+	SYM	SYM	_	_	_	_	_
11	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
12	in	in	ADP	IN	_	_	_	_	_
13	AITL/	AITLith	ADP	IN	Abbr=Yes	_	_	_	SpaceAfter=No
14	GC	GC	PROPN	NNP	Number=Sing	_	_	_	_
15	were	be	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
16	Bcl6+/CD3+/CD20-/CD57-	Bcl6+/CD3+/CD20-/CD57-	SYM	NFP	_	_	_	_	_

# sent_id = 3842
# text = T cells.
1	T	t	PROPN	NNP	Number=Sing	_	_	_	_
2	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
3	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3843
# text = Moreover, CD3+ intrafollicular
1	Moreover	moreover	ADV	RB	_	_	_	_	SpaceAfter=No
2	,	,	PUNCT	,	_	_	_	_	_
3	CD3	CD3	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
4	+	+	SYM	SYM	_	_	_	_	_
5	intrafollicular	intrafollicular	ADJ	JJ	Degree=Pos	_	_	_	_

# sent_id = 3844
# text = T cells were depleted in AITL/GC, whereas they were abundant in FH.
1	T	t	PROPN	NNP	Number=Sing	_	_	_	_
2	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
3	were	be	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
4	depleted	deplet	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
5	in	in	ADP	IN	_	_	_	_	_
6	AITL/GC	AITL/GC	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
7	,	,	PUNCT	,	_	_	_	_	_
8	whereas	whereas	SCONJ	IN	_	_	_	_	_
9	they	they	PRON	PRP	Case=Nom|Number=Plur|Person=3|PronType=Prs	_	_	_	_
10	were	be	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
11	abundant	abundant	ADV	RB	_	_	_	_	_
12	in	in	ADP	IN	_	_	_	_	_
13	FH	FH	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
14	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3845
# text = Intrafollicular CD57+ cells did not stain for Bcl-6, and were also depleted in AITL/GC.
1	Intrafollicular	Intrafollicular	ADJ	JJ	Degree=Pos	_	_	_	_
2	CD57	CD57	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
3	+	+	SYM	SYM	_	_	_	_	_
4	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
5	did	do	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
6	not	not	PART	RB	_	_	_	_	_
7	stain	stain	VERB	VB	VerbForm=Inf	_	_	_	_
8	for	for	ADP	IN	_	_	_	_	_
9	Bcl	Bcl	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
10	-6	-6	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
11	,	,	PUNCT	,	_	_	_	_	_
12	and	and	CCONJ	CC	_	_	_	_	_
13	were	be	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
14	also	also	ADV	RB	_	_	_	_	_
15	depleted	deplet	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
16	in	in	ADP	IN	_	_	_	_	_
17	AITL	AITL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
18	/GC	/GC	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
19	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3846
# text = In typical AITL, some neoplastic cells were positive for Bcl-6, showing variable degrees of staining.
1	In	in	ADP	IN	_	_	_	_	_
2	typical	typical	ADJ	JJ	Degree=Pos	_	_	_	_
3	AITL	Aitl	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
4	,	,	PUNCT	,	_	_	_	_	_
5	some	some	DET	DT	_	_	_	_	_
6	neoplastic	neoplastic	ADJ	JJ	Degree=Pos	_	_	_	_
7	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
8	were	be	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
9	positive	positive	ADJ	JJ	Degree=Pos	_	_	_	_
10	for	for	ADP	IN	_	_	_	_	_
11	Bcl	Bcl	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
12	-6	-6	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
13	,	,	PUNCT	,	_	_	_	_	_
14	showing	show	VERB	VBG	VerbForm=Ger	_	_	_	_
15	variable	variable	ADJ	JJ	Degree=Pos	_	_	_	_
16	degrees	degree	NOUN	NNS	Number=Plur	_	_	_	_
17	of	of	ADP	IN	_	_	_	_	_
18	staining	staining	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
19	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3847
# text = CONCLUSIONS: (1) GCs of AITL/GC differed from those of other reactive follicular hyperplasias and follicular lymphomas, and staining for Bcl-6 was useful to discern them.
1	CONCLUSIONS	conclusion	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
2	:	:	PUNCT	:	_	_	_	_	_
3	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
4	1	1	X	LS	_	_	_	_	SpaceAfter=No
5	)	)	PUNCT	-RRB-	_	_	_	_	_
6	GCs	Gcs	NOUN	NNS	Number=Plur	_	_	_	_
7	of	of	ADP	IN	_	_	_	_	_
8	AITL	AITL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
9	/	/	PUNCT	,	_	_	_	_	SpaceAfter=No
10	GC	GC	PROPN	NNP	Number=Sing	_	_	_	_
11	differed	differ	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
12	from	from	ADP	IN	_	_	_	_	_
13	those	those	PRON	DT	Number=Plur|PronType=Dem	_	_	_	_
14	of	of	ADP	IN	_	_	_	_	_
15	other	other	ADJ	JJ	Degree=Pos	_	_	_	_
16	reactive	reactive	ADJ	JJ	Degree=Pos	_	_	_	_
17	follicular	follicular	ADJ	JJ	Degree=Pos	_	_	_	_
18	hyperplasias	hyperplasia	NOUN	NNS	Number=Plur	_	_	_	_
19	and	and	CCONJ	CC	_	_	_	_	_
20	follicular	follicular	ADJ	JJ	Degree=Pos	_	_	_	_
21	lymphomas	lymphoma	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
22	,	,	PUNCT	,	_	_	_	_	_
23	and	and	CCONJ	CC	_	_	_	_	_
24	staining	stai	VERB	VBG	VerbForm=Ger	_	_	_	_
25	for	for	ADP	IN	_	_	_	_	_
26	Bcl	Bcl	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
27	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
28	6	6	NUM	CD	NumType=Card	_	_	_	_
29	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
30	useful	useful	ADJ	JJ	Degree=Pos	_	_	_	_
31	to	to	PART	TO	_	_	_	_	_
32	discern	discern	VERB	VB	VerbForm=Inf	_	_	_	_
33	them	they	PRON	PRP	Case=Acc|Number=Plur|Person=3|PronType=Prs	_	_	_	SpaceAfter=No
34	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3848
# text = (2)
1	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
2	2	2	X	LS	_	_	_	_	SpaceAfter=No
3	)	)	PUNCT	-RRB-	_	_	_	_	_

# sent_id = 3849
# text = Intrafollicular CD3+ T cells, many of which were also positive for Bcl-6, were markedly depleted in AITL/GC, with increased interfollicular Bcl-6+/CD3+ cells, suggesting an outward migration of intrafollicular
1	Intrafollicular	Intrafollicular	ADJ	JJ	Degree=Pos	_	_	_	_
2	CD3	CD3	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
3	+	+	SYM	SYM	_	_	_	_	_
4	T	t	NUM	CD	NumType=Card	_	_	_	_
5	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
6	,	,	PUNCT	,	_	_	_	_	_
7	many	many	ADJ	JJ	Degree=Pos	_	_	_	_
8	of	of	ADP	IN	_	_	_	_	_
9	which	which	PRON	WDT	PronType=Int	_	_	_	_
10	were	be	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
11	also	also	ADV	RB	_	_	_	_	_
12	positive	positive	ADJ	JJ	Degree=Pos	_	_	_	_
13	for	for	ADP	IN	_	_	_	_	_
14	Bcl	Bcl	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
15	-6	-6	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
16	,	,	PUNCT	,	_	_	_	_	_
17	were	be	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
18	markedly	markedly	ADV	RB	_	_	_	_	_
19	depleted	deplet	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
20	in	in	ADP	IN	_	_	_	_	_
21	AITL	AITL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
22	/	/	PUNCT	,	_	_	_	_	SpaceAfter=No
23	GC	GC	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
24	,	,	PUNCT	,	_	_	_	_	_
25	with	with	ADP	IN	_	_	_	_	_
26	increased	increase	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
27	interfollicular	interfollicular	ADJ	JJ	Degree=Pos	_	_	_	_
28	Bcl-6+/CD3	Bcl-6+/CD3	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
29	+	+	SYM	SYM	_	_	_	_	_
30	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
31	,	,	PUNCT	,	_	_	_	_	_
32	suggesting	suggest	VERB	VBG	VerbForm=Ger	_	_	_	_
33	an	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
34	outward	outward	ADJ	JJ	Degree=Pos	_	_	_	_
35	migration	migration	NOUN	NN	Number=Sing	_	_	_	_
36	of	of	ADP	IN	_	_	_	_	_
37	intrafollicular	intrafollicular	ADJ	JJ	Degree=Pos	_	_	_	_

# sent_id = 3850
# text = T cells in this condition.
1	T	t	ADJ	JJ	Degree=Pos	_	_	_	_
2	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
3	in	in	ADP	IN	_	_	_	_	_
4	this	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
5	condition	condition	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
6	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3851
# text = (3) Interfollicular Bcl-6+/CD3+ cells in AITL/GC were too numerous to be accounted for by migration alone, suggesting local proliferation.
1	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
2	3	3	X	LS	_	_	_	_	SpaceAfter=No
3	)	)	PUNCT	-RRB-	_	_	_	_	_
4	Interfollicular	Interfollicular	ADJ	JJ	Degree=Pos	_	_	_	_
5	Bcl-6+/CD3	Bcl-6+/CD3	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
6	+	+	SYM	SYM	_	_	_	_	_
7	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
8	in	in	ADP	IN	_	_	_	_	_
9	AITL	AITL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
10	/	/	PUNCT	,	_	_	_	_	SpaceAfter=No
11	GC	GC	PROPN	NNP	Number=Sing	_	_	_	_
12	were	be	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
13	too	too	ADV	RB	_	_	_	_	_
14	numerous	numerous	ADJ	JJ	Degree=Pos	_	_	_	_
15	to	to	PART	TO	_	_	_	_	_
16	be	be	AUX	VB	VerbForm=Inf	_	_	_	_
17	accounted	account	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
18	for	for	ADP	IN	_	_	_	_	_
19	by	by	ADP	IN	_	_	_	_	_
20	migration	migration	NOUN	NN	Number=Sing	_	_	_	_
21	alone	alone	ADV	RB	_	_	_	_	SpaceAfter=No
22	,	,	PUNCT	,	_	_	_	_	_
23	suggesting	suggest	VERB	VBG	VerbForm=Ger	_	_	_	_
24	local	local	ADJ	JJ	Degree=Pos	_	_	_	_
25	proliferation	proliferation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
26	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3852
# text = (4) Intrafollicular CD57+ cells were negative for Bcl-6, indicating heterogeneity of the intrafollicular T-cell population.
1	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
2	4	4	X	LS	_	_	_	_	SpaceAfter=No
3	)	)	PUNCT	-RRB-	_	_	_	_	_
4	Intrafollicular	Intrafollicular	ADJ	JJ	Degree=Pos	_	_	_	_
5	CD57	CD57	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
6	+	+	SYM	SYM	_	_	_	_	_
7	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
8	were	be	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
9	negative	negative	ADJ	JJ	Degree=Pos	_	_	_	_
10	for	for	ADP	IN	_	_	_	_	_
11	Bcl	Bcl	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
12	-6	-6	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
13	,	,	PUNCT	,	_	_	_	_	_
14	indicating	indicate	VERB	VBG	VerbForm=Ger	_	_	_	_
15	heterogeneity	heterogeneity	NOUN	NN	Number=Sing	_	_	_	_
16	of	of	ADP	IN	_	_	_	_	_
17	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
18	intrafollicular	intrafollicular	ADJ	JJ	Degree=Pos	_	_	_	_
19	T-	t-	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
20	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
21	population	population	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
22	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3853
# text = (5) Some neoplastic cells in AITL stained for Bcl-6, suggesting up-regulation of Bcl-6 expression in this tumor.
1	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
2	5	5	X	LS	_	_	_	_	SpaceAfter=No
3	)	)	PUNCT	-RRB-	_	_	_	_	_
4	Some	some	DET	DT	_	_	_	_	_
5	neoplastic	neoplastic	ADJ	JJ	Degree=Pos	_	_	_	_
6	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
7	in	in	ADP	IN	_	_	_	_	_
8	AITL	AITL	PROPN	NNP	Number=Sing	_	_	_	_
9	stained	stain	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
10	for	for	ADP	IN	_	_	_	_	_
11	Bcl	Bcl	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
12	-6	-6	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
13	,	,	PUNCT	,	_	_	_	_	_
14	suggesting	suggest	VERB	VBG	VerbForm=Ger	_	_	_	_
15	up	up	ADV	RB	_	_	_	_	SpaceAfter=No
16	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
17	regulation	regulation	NOUN	NN	Number=Sing	_	_	_	_
18	of	of	ADP	IN	_	_	_	_	_
19	Bcl	Bcl	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
20	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
21	6	6	NUM	CD	NumType=Card	_	_	_	_
22	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
23	in	in	ADP	IN	_	_	_	_	_
24	this	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
25	tumor.	tumor.	NOUN	NN	Number=Sing	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 3854
# text = Document 003003593 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	003003593	003003593	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 3855
# text = Staphylococcal enterotoxins modulate interleukin 2 receptor expression and ligand-induced tyrosine phosphorylation of the Janus protein-tyrosine kinase 3 (Jak3) and signal transducers and activators of transcription
1	Staphylococcal	Staphylococcal	ADJ	JJ	Degree=Pos	_	_	_	_
2	enterotoxins	enterotoxin	NOUN	NNS	Number=Plur	_	_	_	_
3	modulate	modulate	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
4	interleukin	interleukin	ADJ	JJ	Degree=Pos	_	_	_	_
5	2	2	NUM	CD	NumType=Card	_	_	_	_
6	receptor	receptor	NOUN	NN	Number=Sing	_	_	_	_
7	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
8	and	and	CCONJ	CC	_	_	_	_	_
9	ligand	ligand	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
10	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
11	induced	induce	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
12	tyrosine	tyrosine	NOUN	NN	Number=Sing	_	_	_	_
13	phosphorylation	phosphorylation	NOUN	NN	Number=Sing	_	_	_	_
14	of	of	ADP	IN	_	_	_	_	_
15	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
16	Janus	Janus	PROPN	NNP	Number=Sing	_	_	_	_
17	protein	protein	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
18	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
19	tyrosine	tyrosine	NOUN	NN	Number=Sing	_	_	_	_
20	kinase	kinase	NOUN	NN	Number=Sing	_	_	_	_
21	3	3	NUM	CD	NumType=Card	_	_	_	_
22	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
23	Jak3	Jak3	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
24	)	)	PUNCT	-RRB-	_	_	_	_	_
25	and	and	CCONJ	CC	_	_	_	_	_
26	signal	signal	ADJ	JJ	Degree=Pos	_	_	_	_
27	transducers	transducer	NOUN	NNS	Number=Plur	_	_	_	_
28	and	and	CCONJ	CC	_	_	_	_	_
29	activators	activator	NOUN	NNS	Number=Plur	_	_	_	_
30	of	of	ADP	IN	_	_	_	_	_
31	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_

# sent_id = 3856
# text = (Stat proteins).
1	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
2	Stat	Stat	VERB	VB	Mood=Imp|VerbForm=Fin	_	_	_	_
3	proteins	protein	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
5	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 3857
# text = Staphylococcal enterotoxins (SE) stimulate T cells expressing the appropriate variable region beta chain of (V beta) T-cell receptors and have been implicated in the pathogenesis of several autoimmune diseases.
1	Staphylococcal	Staphylococcal	ADJ	JJ	Degree=Pos	_	_	_	_
2	enterotoxins	enterotoxin	NOUN	NNS	Number=Plur	_	_	_	_
3	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
4	SE	SE	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
5	)	)	PUNCT	-RRB-	_	_	_	_	_
6	stimulate	stimulate	VERB	VB	VerbForm=Inf	_	_	_	_
7	T	t	PROPN	NNP	Number=Sing	_	_	_	_
8	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
9	expressing	expresse	VERB	VBG	VerbForm=Ger	_	_	_	_
10	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
11	appropriate	appropriate	ADJ	JJ	Degree=Pos	_	_	_	_
12	variable	variable	ADJ	JJ	Degree=Pos	_	_	_	_
13	region	region	NOUN	NN	Number=Sing	_	_	_	_
14	beta	beta	NOUN	NN	Number=Sing	_	_	_	_
15	chain	chain	NOUN	NN	Number=Sing	_	_	_	_
16	of	of	ADP	IN	_	_	_	_	_
17	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
18	V	V	PROPN	NNP	Number=Sing	_	_	_	_
19	beta	beta	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
20	)	)	PUNCT	-RRB-	_	_	_	_	_
21	T-	T-	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
22	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
23	receptors	receptor	NOUN	NNS	Number=Plur	_	_	_	_
24	and	and	CCONJ	CC	_	_	_	_	_
25	have	have	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
26	been	be	AUX	VBN	Tense=Past|VerbForm=Part	_	_	_	_
27	implicated	implicate	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
28	in	in	ADP	IN	_	_	_	_	_
29	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
30	pathogenesis	pathogenesis	NOUN	NN	Number=Sing	_	_	_	_
31	of	of	ADP	IN	_	_	_	_	_
32	several	several	ADJ	JJ	Degree=Pos	_	_	_	_
33	autoimmune	autoimmune	NOUN	NN	Number=Sing	_	_	_	_
34	diseases	diseasis	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
35	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3858
# text = Depending on costimulatory signals, SE induce either proliferation or anergy in T cells.
1	Depending	depend	VERB	VBG	VerbForm=Ger	_	_	_	_
2	on	on	ADP	IN	_	_	_	_	_
3	costimulatory	costimulatory	ADJ	JJ	Degree=Pos	_	_	_	_
4	signals	signal	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
5	,	,	PUNCT	,	_	_	_	_	_
6	SE	Se	PROPN	NNP	Number=Sing	_	_	_	_
7	induce	induce	NOUN	NN	Number=Sing	_	_	_	_
8	either	either	CCONJ	CC	_	_	_	_	_
9	proliferation	proliferation	NOUN	NN	Number=Sing	_	_	_	_
10	or	or	CCONJ	CC	_	_	_	_	_
11	anergy	anergy	NOUN	NN	Number=Sing	_	_	_	_
12	in	in	ADP	IN	_	_	_	_	_
13	T	t	PROPN	NNP	Number=Sing	_	_	_	_
14	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
15	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3859
# text = In addition, SE can induce an interleukin-2 (IL-2) nonresponsive state and apoptosis.
1	In	in	ADP	IN	_	_	_	_	_
2	addition	addition	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
3	,	,	PUNCT	,	_	_	_	_	_
4	SE	SE	PROPN	NNP	Number=Sing	_	_	_	_
5	can	can	AUX	MD	VerbForm=Fin	_	_	_	_
6	induce	induce	VERB	VB	VerbForm=Inf	_	_	_	_
7	an	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
8	interleukin	interleukin	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
9	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
10	2	2	NUM	CD	NumType=Card	_	_	_	_
11	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
12	IL	Il	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
13	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
14	2	2	X	LS	_	_	_	_	SpaceAfter=No
15	)	)	PUNCT	-RRB-	_	_	_	_	_
16	nonresponsive	nonresponsive	ADJ	JJ	Degree=Pos	_	_	_	_
17	state	state	NOUN	NN	Number=Sing	_	_	_	_
18	and	and	CCONJ	CC	_	_	_	_	_
19	apoptosis	apoptosis	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
20	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3860
# text = Here, we show that SE induce dynamic changes in the expression of and signal transduction through the IL-2 receptor (IL-2R) beta and gamma chains (IL-2R beta and IL-2R gamma) in human antigen-specific CD4+ T-cell lines.
1	Here	here	ADV	RB	PronType=Dem	_	_	_	SpaceAfter=No
2	,	,	PUNCT	,	_	_	_	_	_
3	we	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
4	show	show	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
5	that	that	SCONJ	IN	_	_	_	_	_
6	SE	SE	PROPN	NNP	Number=Sing	_	_	_	_
7	induce	induce	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
8	dynamic	dynamic	ADJ	JJ	Degree=Pos	_	_	_	_
9	changes	change	NOUN	NNS	Number=Plur	_	_	_	_
10	in	in	ADP	IN	_	_	_	_	_
11	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
12	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
13	of	of	ADP	IN	_	_	_	_	_
14	and	and	CCONJ	CC	_	_	_	_	_
15	signal	signal	NOUN	NN	Number=Sing	_	_	_	_
16	transduction	transduction	NOUN	NN	Number=Sing	_	_	_	_
17	through	through	ADP	IN	_	_	_	_	_
18	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
19	IL	Il	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
20	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
21	2	2	NUM	CD	NumType=Card	_	_	_	_
22	receptor	receptor	NOUN	NN	Number=Sing	_	_	_	_
23	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
24	IL	Il	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
25	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
26	2R	2r	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
27	)	)	PUNCT	-RRB-	_	_	_	_	_
28	beta	beta	NOUN	NN	Number=Sing	_	_	_	_
29	and	and	CCONJ	CC	_	_	_	_	_
30	gamma	gamma	NOUN	NN	Number=Sing	_	_	_	_
31	chains	chain	NOUN	NNS	Number=Plur	_	_	_	_
32	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
33	IL	Il	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
34	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
35	2R	2r	NOUN	NN	Number=Sing	_	_	_	_
36	beta	beta	NOUN	NN	Number=Sing	_	_	_	_
37	and	and	CCONJ	CC	_	_	_	_	_
38	IL	Il	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
39	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
40	2R	2r	NOUN	NN	Number=Sing	_	_	_	_
41	gamma	gamma	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
42	)	)	PUNCT	-RRB-	_	_	_	_	_
43	in	in	ADP	IN	_	_	_	_	_
44	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
45	antigen	antigen	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
46	-specific	-specific	ADJ	JJ	Degree=Pos	_	_	_	_
47	CD4	Cd4	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
48	+	+	SYM	SYM	_	_	_	_	_
49	T-	t-	SYM	SYM	_	_	_	_	SpaceAfter=No
50	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
51	lines	line	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
52	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3861
# text = Thus, after 4 hr of exposure to SEA and SEB, the expression of IL-2R beta was down-regulated, IL-2R gamma was slightly up-regulated, while IL-2R alpha remained largely unaffected.
1	Thus	thus	ADV	RB	_	_	_	_	SpaceAfter=No
2	,	,	PUNCT	,	_	_	_	_	_
3	after	after	ADP	IN	_	_	_	_	_
4	4	4	NUM	CD	NumType=Card	_	_	_	_
5	hr	hr	NOUN	NN	Number=Sing	_	_	_	_
6	of	of	ADP	IN	_	_	_	_	_
7	exposure	exposure	NOUN	NN	Number=Sing	_	_	_	_
8	to	to	ADP	IN	_	_	_	_	_
9	SEA	sea	NOUN	NN	Number=Sing	_	_	_	_
10	and	and	CCONJ	CC	_	_	_	_	_
11	SEB	SEB	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
12	,	,	PUNCT	,	_	_	_	_	_
13	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
14	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
15	of	of	ADP	IN	_	_	_	_	_
16	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
17	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
18	2R	2R	PROPN	NNP	Number=Sing	_	_	_	_
19	beta	beta	PROPN	NNP	Number=Sing	_	_	_	_
20	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
21	down	down	ADV	RB	_	_	_	_	SpaceAfter=No
22	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
23	regulated	regulate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	SpaceAfter=No
24	,	,	PUNCT	,	_	_	_	_	_
25	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
26	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
27	2	2	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
28	R	r	PROPN	NNP	Number=Sing	_	_	_	_
29	gamma	gamma	PROPN	NNP	Number=Sing	_	_	_	_
30	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
31	slightly	slightly	ADV	RB	_	_	_	_	_
32	up	up	ADV	RB	_	_	_	_	SpaceAfter=No
33	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
34	regulated	regulate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	SpaceAfter=No
35	,	,	PUNCT	,	_	_	_	_	_
36	while	while	SCONJ	IN	_	_	_	_	_
37	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
38	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
39	2R	2R	PROPN	NNP	Number=Sing	_	_	_	_
40	alpha	alpha	NOUN	NN	Number=Sing	_	_	_	_
41	remained	remain	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
42	largely	largely	ADV	RB	_	_	_	_	_
43	unaffected	unaffected	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
44	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3862
# text = The changes in the composition of IL-2Rs were accompanied by inhibition of IL-2-induced tyrosine phosphorylation of the Janus protein-tyrosine kinase 3 (Jak3) and signal transducers and activators of transcription called Stat3 and Stat5.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	changes	change	NOUN	NNS	Number=Plur	_	_	_	_
3	in	in	ADP	IN	_	_	_	_	_
4	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
5	composition	composition	NOUN	NN	Number=Sing	_	_	_	_
6	of	of	ADP	IN	_	_	_	_	_
7	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
8	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
9	2	2	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
10	Rs	R	NOUN	NNS	Number=Plur	_	_	_	_
11	were	be	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
12	accompanied	accompany	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
13	by	by	ADP	IN	_	_	_	_	_
14	inhibition	inhibition	NOUN	NN	Number=Sing	_	_	_	_
15	of	of	ADP	IN	_	_	_	_	_
16	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
17	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
18	2	2	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
19	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
20	induced	induce	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
21	tyrosine	tyrosine	NOUN	NN	Number=Sing	_	_	_	_
22	phosphorylation	phosphorylation	NOUN	NN	Number=Sing	_	_	_	_
23	of	of	ADP	IN	_	_	_	_	_
24	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
25	Janus	Janus	PROPN	NNP	Number=Sing	_	_	_	_
26	protein	protein	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
27	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
28	tyrosine	tyrosine	NOUN	NN	Number=Sing	_	_	_	_
29	kinase	kinase	NOUN	NN	Number=Sing	_	_	_	_
30	3	3	NUM	CD	NumType=Card	_	_	_	_
31	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
32	Jak3	Jak3	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
33	)	)	PUNCT	-RRB-	_	_	_	_	_
34	and	and	CCONJ	CC	_	_	_	_	_
35	signal	signal	ADJ	JJ	Degree=Pos	_	_	_	_
36	transducers	transducer	NOUN	NNS	Number=Plur	_	_	_	_
37	and	and	CCONJ	CC	_	_	_	_	_
38	activators	activator	NOUN	NNS	Number=Plur	_	_	_	_
39	of	of	ADP	IN	_	_	_	_	_
40	transcription	transcription	NOUN	NN	Number=Sing	_	_	_	_
41	called	call	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
42	Stat3	Stat3	NUM	CD	NumType=Card	_	_	_	_
43	and	and	CCONJ	CC	_	_	_	_	_
44	Stat5	stat5	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
45	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3863
# text = In parallel experiments, IL-2-driven proliferation was inhibited significantly.
1	In	in	ADP	IN	_	_	_	_	_
2	parallel	parallel	ADJ	JJ	Degree=Pos	_	_	_	_
3	experiments	experiment	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	,	,	PUNCT	,	_	_	_	_	_
5	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
6	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
7	2	2	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
8	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
9	driven	driven	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
10	proliferation	proliferation	NOUN	NN	Number=Sing	_	_	_	_
11	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
12	inhibited	inhibit	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
13	significantly	significantly	ADV	RB	_	_	_	_	SpaceAfter=No
14	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3864
# text = After 16 hr of exposure to SE, the expression of IL-2R beta remained low, while that of IL2R alpha and IL2R gamma was further up-regulated, and ligand-induced tyrosine phosphorylation of Jak3 and Stat proteins was partly normalized.
1	After	after	ADP	IN	_	_	_	_	_
2	16	16	NUM	CD	NumType=Card	_	_	_	_
3	hr	hr	NOUN	NN	Number=Sing	_	_	_	_
4	of	of	ADP	IN	_	_	_	_	_
5	exposure	exposure	NOUN	NN	Number=Sing	_	_	_	_
6	to	to	ADP	IN	_	_	_	_	_
7	SE	SE	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
8	,	,	PUNCT	,	_	_	_	_	_
9	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
10	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
11	of	of	ADP	IN	_	_	_	_	_
12	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
13	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
14	2R	2R	PROPN	NNP	Number=Sing	_	_	_	_
15	beta	beta	NOUN	NN	Number=Sing	_	_	_	_
16	remained	remain	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
17	low	low	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
18	,	,	PUNCT	,	_	_	_	_	_
19	while	while	SCONJ	IN	_	_	_	_	_
20	that	that	PRON	DT	Number=Sing|PronType=Dem	_	_	_	_
21	of	of	ADP	IN	_	_	_	_	_
22	IL2R	IL2R	PROPN	NNP	Number=Sing	_	_	_	_
23	alpha	alpha	PROPN	NNP	Number=Sing	_	_	_	_
24	and	and	CCONJ	CC	_	_	_	_	_
25	IL2R	IL2R	PROPN	NNP	Number=Sing	_	_	_	_
26	gamma	gamma	PROPN	NNP	Number=Sing	_	_	_	_
27	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
28	further	further	ADV	RB	_	_	_	_	_
29	up	up	ADV	RB	_	_	_	_	SpaceAfter=No
30	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
31	regulated	regulate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	SpaceAfter=No
32	,	,	PUNCT	,	_	_	_	_	_
33	and	and	CCONJ	CC	_	_	_	_	_
34	ligand	ligand	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
35	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
36	induced	induce	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
37	tyrosine	tyrosine	NOUN	NN	Number=Sing	_	_	_	_
38	phosphorylation	phosphorylation	NOUN	NN	Number=Sing	_	_	_	_
39	of	of	ADP	IN	_	_	_	_	_
40	Jak3	Jak3	NOUN	NN	Number=Sing	_	_	_	_
41	and	and	CCONJ	CC	_	_	_	_	_
42	Stat	Stat	NOUN	NN	Number=Sing	_	_	_	_
43	proteins	protein	NOUN	NNS	Number=Plur	_	_	_	_
44	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
45	partly	partly	ADV	RB	_	_	_	_	_
46	normalized	normalize	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	SpaceAfter=No
47	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3865
# text = Yet, IL-2-driven proliferation remained profoundly inhibited, suggesting that signaling events other than Jak3/Stat activation had also been changed following SE stimulation.
1	Yet	yet	CCONJ	CC	_	_	_	_	SpaceAfter=No
2	,	,	PUNCT	,	_	_	_	_	_
3	IL	IL	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
4	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
5	2	2	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
6	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
7	driven	driven	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
8	proliferation	proliferation	NOUN	NN	Number=Sing	_	_	_	_
9	remained	remain	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
10	profoundly	profoundly	ADV	RB	_	_	_	_	_
11	inhibited	inhibit	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	SpaceAfter=No
12	,	,	PUNCT	,	_	_	_	_	_
13	suggesting	suggest	VERB	VBG	VerbForm=Ger	_	_	_	_
14	that	that	SCONJ	IN	_	_	_	_	_
15	signaling	signal	VERB	VBG	VerbForm=Ger	_	_	_	_
16	events	event	NOUN	NNS	Number=Plur	_	_	_	_
17	other	other	ADJ	JJ	Degree=Pos	_	_	_	_
18	than	than	ADP	IN	_	_	_	_	_
19	Jak3	Jak3	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
20	/	/	PUNCT	,	_	_	_	_	SpaceAfter=No
21	Stat	Stat	PROPN	NNP	Number=Sing	_	_	_	_
22	activation	activation	NOUN	NN	Number=Sing	_	_	_	_
23	had	have	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
24	also	also	ADV	RB	_	_	_	_	_
25	been	be	AUX	VBN	Tense=Past|VerbForm=Part	_	_	_	_
26	changed	change	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
27	following	follow	VERB	VBG	VerbForm=Ger	_	_	_	_
28	SE	Se	ADJ	JJ	Degree=Pos	_	_	_	_
29	stimulation	stimulation	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
30	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3866
# text = In conclusion, our data suggest that SE can modulate IL-2R expression and signal transduction involving the Jak/Stat pathway in CD4+ T-cell lines.
1	In	in	ADP	IN	_	_	_	_	_
2	conclusion	conclusion	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
3	,	,	PUNCT	,	_	_	_	_	_
4	our	we	PRON	PRP$	Number=Plur|Person=1|Poss=Yes|PronType=Prs	_	_	_	_
5	data	data	NOUN	NN	Number=Sing	_	_	_	_
6	suggest	suggest	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
7	that	that	SCONJ	IN	_	_	_	_	_
8	SE	SE	PROPN	NNP	Number=Sing	_	_	_	_
9	can	can	AUX	MD	VerbForm=Fin	_	_	_	_
10	modulate	modulate	VERB	VB	VerbForm=Inf	_	_	_	_
11	IL	Il	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
12	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
13	2R	2r	PROPN	NNP	Number=Sing	_	_	_	_
14	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
15	and	and	CCONJ	CC	_	_	_	_	_
16	signal	signal	NOUN	NN	Number=Sing	_	_	_	_
17	transduction	transduction	NOUN	NN	Number=Sing	_	_	_	_
18	involving	involve	VERB	VBG	VerbForm=Ger	_	_	_	_
19	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
20	Jak	Jak	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
21	/	/	PUNCT	,	_	_	_	_	SpaceAfter=No
22	Stat	Stat	PROPN	NNP	Number=Sing	_	_	_	_
23	pathway	pathway	NOUN	NN	Number=Sing	_	_	_	_
24	in	in	ADP	IN	_	_	_	_	_
25	CD4	CD4	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
26	+	+	SYM	SYM	_	_	_	_	_
27	T-	T-	SYM	NFP	_	_	_	_	SpaceAfter=No
28	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
29	lines	line	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
30	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 3867
# text = Document 003003595 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	003003595	003003595	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 3868
# text = The 56-59-kilodalton protein identified in untransformed steroid receptor complexes is a unique protein that exists in cytosol in a complex with both the 70- and 90-kilodalton heat shock proteins.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	56	56	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
3	-	-	SYM	SYM	_	_	_	_	SpaceAfter=No
4	59	59	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
5	-kilodalton	-kilodalton	NUM	CD	NumType=Card	_	_	_	_
6	protein	protein	NOUN	NN	Number=Sing	_	_	_	_
7	identified	identify	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
8	in	in	ADP	IN	_	_	_	_	_
9	untransformed	untransformed	ADJ	JJ	Degree=Pos	_	_	_	_
10	steroid	steroid	ADJ	JJ	Degree=Pos	_	_	_	_
11	receptor	receptor	NOUN	NN	Number=Sing	_	_	_	_
12	complexes	complex	NOUN	NNS	Number=Plur	_	_	_	_
13	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
14	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
15	unique	unique	ADJ	JJ	Degree=Pos	_	_	_	_
16	protein	protein	NOUN	NN	Number=Sing	_	_	_	_
17	that	that	PRON	WDT	PronType=Rel	_	_	_	_
18	exists	exist	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
19	in	in	ADP	IN	_	_	_	_	_
20	cytosol	cytosol	NOUN	NN	Number=Sing	_	_	_	_
21	in	in	ADP	IN	_	_	_	_	_
22	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
23	complex	complex	NOUN	NN	Number=Sing	_	_	_	_
24	with	with	ADP	IN	_	_	_	_	_
25	both	both	CCONJ	CC	_	_	_	_	_
26	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
27	70	70	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
28	-	-	PUNCT	HYPH	_	_	_	_	_
29	and	and	CCONJ	CC	_	_	_	_	_
30	90	90	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
31	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
32	kilodalton	kilodalton	NOUN	NN	Number=Sing	_	_	_	_
33	heat	heat	NOUN	NN	Number=Sing	_	_	_	_
34	shock	shock	NOUN	NN	Number=Sing	_	_	_	_
35	proteins	protein	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
36	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 3869
# text = It has previously been shown that 9S, untransformed progestin, estrogen, androgen, and glucocorticoid receptor complexes in rabbit uterine and liver cytosols contain a 59-kDa protein [Tai, P.K., Maeda, Y., Nakao, K., Wakim, N.G., Duhring, J.L., & Faber, L.E.(1986) Biochemistry 25, 5269-5275].
1	It	it	PRON	PRP	Case=Nom|Gender=Neut|Number=Sing|Person=3|PronType=Prs	_	_	_	_
2	has	have	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
3	previously	previously	ADV	RB	_	_	_	_	_
4	been	be	AUX	VBN	Tense=Past|VerbForm=Part	_	_	_	_
5	shown	show	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
6	that	that	SCONJ	IN	_	_	_	_	_
7	9	9	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
8	S	s	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
9	,	,	PUNCT	,	_	_	_	_	_
10	untransformed	untransformed	ADJ	JJ	Degree=Pos	_	_	_	_
11	progestin	progestin	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
12	,	,	PUNCT	,	_	_	_	_	_
13	estrogen	estrogen	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
14	,	,	PUNCT	,	_	_	_	_	_
15	androgen	androgen	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
16	,	,	PUNCT	,	_	_	_	_	_
17	and	and	CCONJ	CC	_	_	_	_	_
18	glucocorticoid	glucocorticoid	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
19	receptor	receptor	NOUN	NN	Number=Sing	_	_	_	_
20	complexes	complex	NOUN	NNS	Number=Plur	_	_	_	_
21	in	in	ADP	IN	_	_	_	_	_
22	rabbit	rabbit	NOUN	NN	Number=Sing	_	_	_	_
23	uterine	uterine	NOUN	NN	Number=Sing	_	_	_	_
24	and	and	CCONJ	CC	_	_	_	_	_
25	liver	liver	NOUN	NN	Number=Sing	_	_	_	_
26	cytosols	cytosol	NOUN	NNS	Number=Plur	_	_	_	_
27	contain	contain	VERB	VB	VerbForm=Inf	_	_	_	_
28	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
29	59	59	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
30	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
31	kDa	kDa	NOUN	NN	Number=Sing	_	_	_	_
32	protein	protein	NOUN	NN	Number=Sing	_	_	_	_
33	[	[	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
34	Tai	Tai	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
35	,	,	PUNCT	,	_	_	_	_	_
36	P.K.	P.K.	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
37	,	,	PUNCT	,	_	_	_	_	_
38	Maeda	Maeda	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
39	,	,	PUNCT	,	_	_	_	_	_
40	Y.	Y.	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
41	,	,	PUNCT	,	_	_	_	_	_
42	Nakao	Nakao	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
43	,	,	PUNCT	,	_	_	_	_	_
44	K.	K.	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
45	,	,	PUNCT	,	_	_	_	_	_
46	Wakim	Wakim	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
47	,	,	PUNCT	,	_	_	_	_	_
48	N.G.	N.G.	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
49	,	,	PUNCT	,	_	_	_	_	_
50	Duhring	Duhr	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
51	,	,	PUNCT	,	_	_	_	_	_
52	J.L.	J.L.	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
53	,	,	PUNCT	,	_	_	_	_	_
54	&	&	CCONJ	CC	_	_	_	_	_
55	Faber	Faber	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
56	,	,	PUNCT	,	_	_	_	_	_
57	L.E.	L.E.	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
58	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
59	1986	1986	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
60	)	)	PUNCT	-RRB-	_	_	_	_	_
61	Biochemistry	Biochemistry	NOUN	NN	Number=Sing	_	_	_	_
62	25	25	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
63	,	,	PUNCT	,	_	_	_	_	_
64	5269	5269	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
65	-	-	SYM	SYM	_	_	_	_	SpaceAfter=No
66	5275	5275	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
67	]	]	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
68	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3870
# text = In this work we show that the monoclonal antibody KN 382/EC1 raised against the rabbit 59-kDa protein reacts with 9S, untransformed glucocorticoid receptor complexes in cytosol prepared from human IM-9 lymphocytes but not with 4S salt-transformed receptors.
1	In	in	ADP	IN	_	_	_	_	_
2	this	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
3	work	work	NOUN	NN	Number=Sing	_	_	_	_
4	we	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
5	show	show	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
6	that	that	SCONJ	IN	_	_	_	_	_
7	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
8	monoclonal	monoclonal	ADJ	JJ	Degree=Pos	_	_	_	_
9	antibody	antibody	NOUN	NN	Number=Sing	_	_	_	_
10	KN	KN	NOUN	NN	Number=Sing	_	_	_	_
11	382/	382/	ADP	IN	Abbr=Yes	_	_	_	SpaceAfter=No
12	EC1	Ec1	PROPN	NNP	Number=Sing	_	_	_	_
13	raised	raise	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
14	against	against	ADP	IN	_	_	_	_	_
15	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
16	rabbit	rabbit	NOUN	NN	Number=Sing	_	_	_	_
17	59	59	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
18	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
19	kDa	kDa	NOUN	NN	Number=Sing	_	_	_	_
20	protein	protein	NOUN	NN	Number=Sing	_	_	_	_
21	reacts	react	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
22	with	with	ADP	IN	_	_	_	_	_
23	9	9	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
24	S	s	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
25	,	,	PUNCT	,	_	_	_	_	_
26	untransformed	untransformed	ADJ	JJ	Degree=Pos	_	_	_	_
27	glucocorticoid	glucocorticoid	ADJ	JJ	Degree=Pos	_	_	_	_
28	receptor	receptor	NOUN	NN	Number=Sing	_	_	_	_
29	complexes	complex	NOUN	NNS	Number=Plur	_	_	_	_
30	in	in	ADP	IN	_	_	_	_	_
31	cytosol	cytosol	NOUN	NN	Number=Sing	_	_	_	_
32	prepared	prepare	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
33	from	from	ADP	IN	_	_	_	_	_
34	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
35	IM	Im	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
36	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
37	9	9	NUM	CD	NumType=Card	_	_	_	_
38	lymphocytes	lymphocyte	NOUN	NNS	Number=Plur	_	_	_	_
39	but	but	CCONJ	CC	_	_	_	_	_
40	not	not	ADV	RB	_	_	_	_	_
41	with	with	ADP	IN	_	_	_	_	_
42	4	4	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
43	S	S	PROPN	NNP	Number=Sing	_	_	_	_
44	salt	salt	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
45	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
46	transformed	transform	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
47	receptors	receptor	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
48	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3871
# text = The human protein recognized by the EC1 antibody is a 56-kDa protein (p56) of moderate abundance located predominantly in the cytoplasm by indirect immunofluorescence.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
3	protein	protein	NOUN	NN	Number=Sing	_	_	_	_
4	recognized	recognize	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
5	by	by	ADP	IN	_	_	_	_	_
6	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
7	EC1	EC1	PROPN	NNP	Number=Sing	_	_	_	_
8	antibody	antibody	NOUN	NN	Number=Sing	_	_	_	_
9	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
10	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
11	56	56	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
12	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
13	kDa	kDa	NOUN	NN	Number=Sing	_	_	_	_
14	protein	protein	NOUN	NN	Number=Sing	_	_	_	_
15	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
16	p56	p56	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
17	)	)	PUNCT	-RRB-	_	_	_	_	_
18	of	of	ADP	IN	_	_	_	_	_
19	moderate	moderate	ADJ	JJ	Degree=Pos	_	_	_	_
20	abundance	abundance	NOUN	NN	Number=Sing	_	_	_	_
21	located	locate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
22	predominantly	predominantly	ADV	RB	_	_	_	_	_
23	in	in	ADP	IN	_	_	_	_	_
24	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
25	cytoplasm	cytoplasm	NOUN	NN	Number=Sing	_	_	_	_
26	by	by	ADP	IN	_	_	_	_	_
27	indirect	indirect	ADJ	JJ	Degree=Pos	_	_	_	_
28	immunofluorescence	immunofluorescence	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
29	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3872
# text = There are at least six isomorphs of p56 by two-dimensional gel analysis.
1	There	there	PRON	EX	_	_	_	_	_
2	are	be	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
3	at	at	ADV	RB	_	_	_	_	_
4	least	least	ADV	RBS	Degree=Sup	_	_	_	_
5	six	six	NUM	CD	NumType=Card	_	_	_	_
6	isomorphs	isomorph	NOUN	NNS	Number=Plur	_	_	_	_
7	of	of	ADP	IN	_	_	_	_	_
8	p56	p56	NUM	CD	NumType=Card	_	_	_	_
9	by	by	ADP	IN	_	_	_	_	_
10	two	two	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
11	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
12	dimensional	dimensional	ADJ	JJ	Degree=Pos	_	_	_	_
13	gel	gel	NOUN	NN	Number=Sing	_	_	_	_
14	analysis	analysis	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
15	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3873
# text = N-Terminal sequencing (20 amino acids) shows that p56 is a unique human protein.
1	N-	N-	SYM	NFP	_	_	_	_	SpaceAfter=No
2	Terminal	Terminal	NOUN	NN	Number=Sing	_	_	_	_
3	sequencing	sequencing	NOUN	NN	Number=Sing	_	_	_	_
4	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
5	20	20	NUM	CD	NumType=Card	_	_	_	_
6	amino	amino	NOUN	NN	Number=Sing	_	_	_	_
7	acids	acid	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
8	)	)	PUNCT	-RRB-	_	_	_	_	_
9	shows	show	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
10	that	that	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
11	p56	p56	NOUN	NN	Number=Sing	_	_	_	_
12	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
13	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
14	unique	unique	ADJ	JJ	Degree=Pos	_	_	_	_
15	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
16	protein	protein	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
17	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3874
# text = When p56 is immunoadsorbed from IM-9 cell cytosol, both the 70- and 90-kDa heat shock proteins are coadsorbed in an immune-specific manner.
1	When	when	ADV	WRB	PronType=Int	_	_	_	_
2	p56	p56	NUM	CD	NumType=Card	_	_	_	_
3	is	be	AUX	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
4	immunoadsorbed	immunoadsor	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
5	from	from	ADP	IN	_	_	_	_	_
6	IM	Im	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
7	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
8	9	9	NUM	CD	NumType=Card	_	_	_	_
9	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
10	cytosol	cytosol	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
11	,	,	PUNCT	,	_	_	_	_	_
12	both	both	CCONJ	CC	_	_	_	_	_
13	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
14	70	70	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
15	-	-	PUNCT	,	_	_	_	_	_
16	and	and	CCONJ	CC	_	_	_	_	_
17	90	90	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
18	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
19	kDa	kDa	NOUN	NN	Number=Sing	_	_	_	_
20	heat	heat	NOUN	NN	Number=Sing	_	_	_	_
21	shock	shock	NOUN	NN	Number=Sing	_	_	_	_
22	proteins	protein	NOUN	NNS	Number=Plur	_	_	_	_
23	are	be	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
24	coadsorbed	coadsor	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
25	in	in	ADP	IN	_	_	_	_	_
26	an	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
27	immune-specific	immune-specific	ADJ	JJ	Degree=Pos	_	_	_	_
28	manner	manner	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
29	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3875
# text = Neither heat shock protein reacts directly with the EC1 antibody.
1	Neither	neither	DET	DT	_	_	_	_	_
2	heat	heat	NOUN	NN	Number=Sing	_	_	_	_
3	shock	shock	NOUN	NN	Number=Sing	_	_	_	_
4	protein	protein	NOUN	NN	Number=Sing	_	_	_	_
5	reacts	react	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
6	directly	directly	ADV	RB	_	_	_	_	_
7	with	with	ADP	IN	_	_	_	_	_
8	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
9	EC1	ec1	PROPN	NNP	Number=Sing	_	_	_	_
10	antibody	antibody	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
11	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3876
# text = We conclude that p56 exists in cytosol in a higher order complex containing hsp70 and hsp90, both of which in turn have been found to be associated with untransformed steroid receptors.
1	We	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
2	conclude	conclude	VERB	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
3	that	that	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
4	p56	p56	NOUN	NN	Number=Sing	_	_	_	_
5	exists	exist	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
6	in	in	ADP	IN	_	_	_	_	_
7	cytosol	cytosol	NOUN	NN	Number=Sing	_	_	_	_
8	in	in	ADP	IN	_	_	_	_	_
9	a	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
10	higher	higher	ADJ	JJR	Degree=Cmp	_	_	_	_
11	order	order	NOUN	NN	Number=Sing	_	_	_	_
12	complex	complex	NOUN	NN	Number=Sing	_	_	_	_
13	containing	contain	VERB	VBG	VerbForm=Ger	_	_	_	_
14	hsp70	hsp70	NUM	CD	NumType=Card	_	_	_	_
15	and	and	CCONJ	CC	_	_	_	_	_
16	hsp90	hsp90	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
17	,	,	PUNCT	,	_	_	_	_	_
18	both	both	DET	DT	_	_	_	_	_
19	of	of	ADP	IN	_	_	_	_	_
20	which	which	PRON	WDT	PronType=Rel	_	_	_	_
21	in	in	ADP	IN	_	_	_	_	_
22	turn	turn	NOUN	NN	Number=Sing	_	_	_	_
23	have	have	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
24	been	be	AUX	VBN	Tense=Past|VerbForm=Part	_	_	_	_
25	found	find	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
26	to	to	PART	TO	_	_	_	_	_
27	be	be	AUX	VB	VerbForm=Inf	_	_	_	_
28	associated	associate	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
29	with	with	ADP	IN	_	_	_	_	_
30	untransformed	untransform	ADJ	JJ	Degree=Pos	_	_	_	_
31	steroid	steroid	NOUN	NN	Number=Sing	_	_	_	_
32	receptors	receptor	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
33	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n\n\n

# newpar
# sent_id = 3877
# text = Document 003003596 ends.
1	Document	document	NOUN	NN	Number=Sing	_	_	_	_
2	003003596	003003596	NUM	CD	NumType=Card	_	_	_	_
3	ends	end	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
4	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\n\n\n

# newpar
# sent_id = 3878
# text = Oncogenicity of human papillomavirus- or adenovirus-transformed cells correlates with resistance to lysis by natural killer cells.
1	Oncogenicity	Oncogenicity	NOUN	NN	Number=Sing	_	_	_	_
2	of	of	ADP	IN	_	_	_	_	_
3	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
4	papillomavirus	papillomavirus	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
5	-	-	PUNCT	,	_	_	_	_	_
6	or	or	CCONJ	CC	_	_	_	_	_
7	adenovirus	adenovirus	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
8	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
9	transformed	transform	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
10	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
11	correlates	correlate	NOUN	NNS	Number=Plur	_	_	_	_
12	with	with	ADP	IN	_	_	_	_	_
13	resistance	resistance	NOUN	NN	Number=Sing	_	_	_	_
14	to	to	ADP	IN	_	_	_	_	_
15	lysis	lysis	PRON	DT	Number=Sing|PronType=Dem	_	_	_	_
16	by	by	ADP	IN	_	_	_	_	_
17	natural	natural	ADJ	JJ	Degree=Pos	_	_	_	_
18	killer	killer	NOUN	NN	Number=Sing	_	_	_	_
19	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
20	.	.	PUNCT	.	_	_	_	_	SpacesAfter=\s\n

# sent_id = 3879
# text = The reasons for the dissimilar oncogenicities of human adenoviruses and human papillomaviruses (HPV) in humans are unknown but may relate to differences in the capacities of the E1A and E7 proteins to target cells for rejection by the host natural killer (NK) cell response.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	reasons	reason	NOUN	NNS	Number=Plur	_	_	_	_
3	for	for	ADP	IN	_	_	_	_	_
4	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
5	dissimilar	dissimilar	ADJ	JJ	Degree=Pos	_	_	_	_
6	oncogenicities	oncogenicity	NOUN	NNS	Number=Plur	_	_	_	_
7	of	of	ADP	IN	_	_	_	_	_
8	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
9	adenoviruses	adenoviruse	NOUN	NNS	Number=Plur	_	_	_	_
10	and	and	CCONJ	CC	_	_	_	_	_
11	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
12	papillomaviruses	papillomaviruse	NOUN	NNS	Number=Plur	_	_	_	_
13	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
14	HPV	HPV	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
15	)	)	PUNCT	-RRB-	_	_	_	_	_
16	in	in	ADP	IN	_	_	_	_	_
17	humans	human	NOUN	NNS	Number=Plur	_	_	_	_
18	are	be	AUX	VBP	Mood=Ind|Tense=Pres|VerbForm=Fin	_	_	_	_
19	unknown	unknown	ADJ	JJ	Degree=Pos	_	_	_	_
20	but	but	CCONJ	CC	_	_	_	_	_
21	may	may	AUX	MD	VerbForm=Fin	_	_	_	_
22	relate	relate	VERB	VB	VerbForm=Inf	_	_	_	_
23	to	to	ADP	IN	_	_	_	_	_
24	differences	difference	NOUN	NNS	Number=Plur	_	_	_	_
25	in	in	ADP	IN	_	_	_	_	_
26	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
27	capacities	capacity	NOUN	NNS	Number=Plur	_	_	_	_
28	of	of	ADP	IN	_	_	_	_	_
29	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
30	E1A	E1a	PROPN	NNP	Number=Sing	_	_	_	_
31	and	and	CCONJ	CC	_	_	_	_	_
32	E7	E7	NUM	CD	NumType=Card	_	_	_	_
33	proteins	protein	NOUN	NNS	Number=Plur	_	_	_	_
34	to	to	PART	TO	_	_	_	_	_
35	target	target	VERB	VB	VerbForm=Inf	_	_	_	_
36	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
37	for	for	ADP	IN	_	_	_	_	_
38	rejection	rejection	NOUN	NN	Number=Sing	_	_	_	_
39	by	by	ADP	IN	_	_	_	_	_
40	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
41	host	host	ADV	RBS	_	_	_	_	_
42	natural	natural	ADJ	JJ	Degree=Pos	_	_	_	_
43	killer	killer	NOUN	NN	Number=Sing	_	_	_	_
44	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
45	NK	NK	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
46	)	)	PUNCT	-RRB-	_	_	_	_	_
47	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
48	response	response	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
49	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3880
# text = As one test of this hypothesis, we compared the abilities of E1A- and E7-expressing human fibroblastic or keratinocyte-derived human cells to be selectively killed by either unstimulated or interferon (IFN)-activated NK cells.
1	As	as	SCONJ	IN	_	_	_	_	_
2	one	one	NUM	CD	NumType=Card	_	_	_	_
3	test	test	NOUN	NN	Number=Sing	_	_	_	_
4	of	of	ADP	IN	_	_	_	_	_
5	this	this	DET	DT	Number=Sing|PronType=Dem	_	_	_	_
6	hypothesis	hypothesis	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
7	,	,	PUNCT	,	_	_	_	_	_
8	we	we	PRON	PRP	Case=Nom|Number=Plur|Person=1|PronType=Prs	_	_	_	_
9	compared	compare	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
10	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
11	abilities	abilitie	NOUN	NNS	Number=Plur	_	_	_	_
12	of	of	ADP	IN	_	_	_	_	_
13	E1A	E1A	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
14	-	-	PUNCT	,	_	_	_	_	_
15	and	and	CCONJ	CC	_	_	_	_	_
16	E7	E7	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
17	-expressing	-expresse	VERB	VBG	VerbForm=Ger	_	_	_	_
18	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
19	fibroblastic	fibroblastic	NOUN	NN	Number=Sing	_	_	_	_
20	or	or	CCONJ	CC	_	_	_	_	_
21	keratinocyte	keratinocyte	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
22	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
23	derived	derive	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
24	human	human	ADJ	JJ	Degree=Pos	_	_	_	_
25	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
26	to	to	PART	TO	_	_	_	_	_
27	be	be	AUX	VB	VerbForm=Inf	_	_	_	_
28	selectively	selectively	ADV	RB	_	_	_	_	_
29	killed	kill	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
30	by	by	ADP	IN	_	_	_	_	_
31	either	either	CCONJ	CC	_	_	_	_	_
32	unstimulated	unstimulate	ADJ	JJ	Degree=Pos	_	_	_	_
33	or	or	CCONJ	CC	_	_	_	_	_
34	interferon	interferon	NOUN	NN	Number=Sing	_	_	_	_
35	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
36	IFN	IFN	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
37	)	)	PUNCT	-RRB-	_	_	_	_	SpaceAfter=No
38	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
39	activated	activated	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
40	NK	Nk	PROPN	NNP	Number=Sing	_	_	_	_
41	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
42	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3881
# text = Cells expressing the E1A oncoprotein were selectively killed by unstimulated NK cells, while the same parental cells but expressing the HPV type 16 (HPV-16) or HPV-18 E7 oncoprotein were resistant to NK cell lysis.
1	Cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
2	expressing	express	VERB	VBG	VerbForm=Ger	_	_	_	_
3	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
4	E1A	E1a	NOUN	NN	Number=Sing	_	_	_	_
5	oncoprotein	oncoprotein	ADV	WRB	PronType=Rel	_	_	_	_
6	were	be	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
7	selectively	selectively	ADV	RB	_	_	_	_	_
8	killed	kill	VERB	VBN	Tense=Past|VerbForm=Part|Voice=Pass	_	_	_	_
9	by	by	ADP	IN	_	_	_	_	_
10	unstimulated	unstimulate	ADJ	JJ	Degree=Pos	_	_	_	_
11	NK	Nk	PROPN	NNP	Number=Sing	_	_	_	_
12	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
13	,	,	PUNCT	,	_	_	_	_	_
14	while	while	SCONJ	IN	_	_	_	_	_
15	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
16	same	same	ADJ	JJ	Degree=Pos	_	_	_	_
17	parental	parental	ADJ	JJ	Degree=Pos	_	_	_	_
18	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
19	but	but	CCONJ	CC	_	_	_	_	_
20	expressing	expresse	VERB	VBG	VerbForm=Ger	_	_	_	_
21	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
22	HPV	HPV	PROPN	NNP	Number=Sing	_	_	_	_
23	type	type	NOUN	NN	Number=Sing	_	_	_	_
24	16	16	NUM	CD	NumType=Card	_	_	_	_
25	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
26	HPV	Hpv	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
27	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
28	16	16	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
29	)	)	PUNCT	-RRB-	_	_	_	_	_
30	or	or	CCONJ	CC	_	_	_	_	_
31	HPV	HPV	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
32	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
33	18	18	NUM	CD	NumType=Card	_	_	_	_
34	E7	E7	NUM	CD	NumType=Card	_	_	_	_
35	oncoprotein	oncoprotein	NOUN	NN	Number=Sing	_	_	_	_
36	were	be	AUX	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
37	resistant	resistant	ADJ	JJ	Degree=Pos	_	_	_	_
38	to	to	ADP	IN	_	_	_	_	_
39	NK	Nk	PROPN	NNP	Number=Sing	_	_	_	_
40	cell	cell	PROPN	NNP	Number=Sing	_	_	_	_
41	lysis	lysis	PROPN	NNPS	Number=Plur	_	_	_	SpaceAfter=No
42	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3882
# text = The ability of IFN-activated NK cells to selectively kill virally transformed cells depends on IFN's ability to induce resistance to NK cell lysis in normal (i.e., non-viral oncogene-expressing) but not virally transformed cells.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	ability	ability	NOUN	NN	Number=Sing	_	_	_	_
3	of	of	ADP	IN	_	_	_	_	_
4	IFN	IFN	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
5	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
6	activated	activate	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
7	NK	Nk	PROPN	NNP	Number=Sing	_	_	_	_
8	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
9	to	to	PART	TO	_	_	_	_	_
10	selectively	selectively	ADV	RB	_	_	_	_	_
11	kill	kill	VERB	VB	VerbForm=Inf	_	_	_	_
12	virally	virally	ADV	RB	_	_	_	_	_
13	transformed	transform	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
14	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
15	depends	depend	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
16	on	on	ADP	IN	_	_	_	_	_
17	IFN	IFN	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
18	's	's	PART	POS	_	_	_	_	_
19	ability	ability	NOUN	NN	Number=Sing	_	_	_	_
20	to	to	PART	TO	_	_	_	_	_
21	induce	induce	VERB	VB	VerbForm=Inf	_	_	_	_
22	resistance	resistance	NOUN	NN	Number=Sing	_	_	_	_
23	to	to	ADP	IN	_	_	_	_	_
24	NK	Nk	PROPN	NNP	Number=Sing	_	_	_	_
25	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
26	lysis	lysis	NOUN	NN	Number=Sing	_	_	_	_
27	in	in	ADP	IN	_	_	_	_	_
28	normal	normal	ADJ	JJ	Degree=Pos	_	_	_	_
29	(	(	PUNCT	-LRB-	_	_	_	_	SpaceAfter=No
30	i.e.	i.e.	X	FW	_	_	_	_	SpaceAfter=No
31	,	,	PUNCT	,	_	_	_	_	_
32	non-viral	non-viral	ADJ	JJ	Degree=Pos	_	_	_	_
33	oncogene	oncogene	ADJ	JJ	Degree=Pos	_	_	_	SpaceAfter=No
34	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
35	expressing	expressing	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
36	)	)	PUNCT	-RRB-	_	_	_	_	_
37	but	but	CCONJ	CC	_	_	_	_	_
38	not	not	ADV	RB	_	_	_	_	_
39	virally	virally	ADV	RB	_	_	_	_	_
40	transformed	transform	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
41	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
42	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3883
# text = E1A blocked IFN's induction of cytolytic resistance, resulting in the selective lysis of adenovirus-transformed cells by IFN-activated NK cells.
1	E1A	E1A	PROPN	NNP	Number=Sing	_	_	_	_
2	blocked	block	VERB	VBD	Mood=Ind|Tense=Past|VerbForm=Fin	_	_	_	_
3	IFN	IFN	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
4	's	's	PART	POS	_	_	_	_	_
5	induction	induction	NOUN	NN	Number=Sing	_	_	_	_
6	of	of	ADP	IN	_	_	_	_	_
7	cytolytic	cytolytic	ADJ	JJ	Degree=Pos	_	_	_	_
8	resistance	resistance	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
9	,	,	PUNCT	,	_	_	_	_	_
10	resulting	result	VERB	VBG	VerbForm=Ger	_	_	_	_
11	in	in	ADP	IN	_	_	_	_	_
12	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
13	selective	selective	ADJ	JJ	Degree=Pos	_	_	_	_
14	lysis	lysis	NOUN	NN	Number=Sing	_	_	_	_
15	of	of	ADP	IN	_	_	_	_	_
16	adenovirus	adenovirus	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
17	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
18	transformed	transform	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
19	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
20	by	by	ADP	IN	_	_	_	_	_
21	IFN	IFN	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
22	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
23	activated	activate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
24	NK	Nk	PROPN	NNP	Number=Sing	_	_	_	_
25	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
26	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3884
# text = The extent of IFN-induced NK cell killing of E1A-expressing cells was proportional to the level of E1A expression and correlated with the ability of E1A to block IFN-stimulated gene expression in target cells.
1	The	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
2	extent	extent	NOUN	NN	Number=Sing	_	_	_	_
3	of	of	ADP	IN	_	_	_	_	_
4	IFN	IFN	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
5	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
6	induced	induce	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
7	NK	Nk	PROPN	NNP	Number=Sing	_	_	_	_
8	cell	cell	NOUN	NN	Number=Sing	_	_	_	_
9	killing	killing	NOUN	NN	Number=Sing	_	_	_	_
10	of	of	ADP	IN	_	_	_	_	_
11	E1A	E1A	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
12	-	-	PUNCT	,	_	_	_	_	SpaceAfter=No
13	expressing	expresse	VERB	VBG	VerbForm=Ger	_	_	_	_
14	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
15	was	be	AUX	VBD	Mood=Ind|Number=Sing|Person=3|Tense=Past|VerbForm=Fin	_	_	_	_
16	proportional	proportional	ADJ	JJ	Degree=Pos	_	_	_	_
17	to	to	ADP	IN	_	_	_	_	_
18	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
19	level	level	NOUN	NN	Number=Sing	_	_	_	_
20	of	of	ADP	IN	_	_	_	_	_
21	E1	E1	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
22	A	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
23	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
24	and	and	CCONJ	CC	_	_	_	_	_
25	correlated	correlate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
26	with	with	ADP	IN	_	_	_	_	_
27	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
28	ability	ability	NOUN	NN	Number=Sing	_	_	_	_
29	of	of	ADP	IN	_	_	_	_	_
30	E1A	E1A	PROPN	NNP	Number=Sing	_	_	_	_
31	to	to	PART	TO	_	_	_	_	_
32	block	block	VERB	VB	VerbForm=Inf	_	_	_	_
33	IFN	Ifn	ADV	RB	_	_	_	_	SpaceAfter=No
34	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
35	stimulated	stimulate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
36	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
37	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
38	in	in	ADP	IN	_	_	_	_	_
39	target	target	NOUN	NN	Number=Sing	_	_	_	_
40	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
41	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3885
# text = In contrast, E7 blocked neither IFN-stimulated gene expression nor IFN's induction of cytolytic resistance, thereby precluding the selective lysis of HPV-transformed cells by IFN-activated NK cells.
1	In	in	ADP	IN	_	_	_	_	_
2	contrast	contrast	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
3	,	,	PUNCT	,	_	_	_	_	_
4	E7	E7	NUM	CD	NumType=Card	_	_	_	_
5	blocked	block	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
6	neither	neither	DET	DT	_	_	_	_	_
7	IFN	IFN	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
8	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
9	stimulated	stimulate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
10	gene	gene	NOUN	NN	Number=Sing	_	_	_	_
11	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
12	nor	nor	CCONJ	CC	_	_	_	_	_
13	IFN	IFN	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
14	's	's	PART	POS	_	_	_	_	_
15	induction	induction	NOUN	NN	Number=Sing	_	_	_	_
16	of	of	ADP	IN	_	_	_	_	_
17	cytolytic	cytolytic	ADJ	JJ	Degree=Pos	_	_	_	_
18	resistance	resistance	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
19	,	,	PUNCT	,	_	_	_	_	_
20	thereby	thereby	ADV	RB	_	_	_	_	_
21	precluding	preclud	VERB	VBG	VerbForm=Ger	_	_	_	_
22	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
23	selective	selective	ADJ	JJ	Degree=Pos	_	_	_	_
24	lysis	lysis	NOUN	NN	Number=Sing	_	_	_	_
25	of	of	ADP	IN	_	_	_	_	_
26	HPV	HPV	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
27	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
28	transformed	transform	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
29	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
30	by	by	ADP	IN	_	_	_	_	_
31	IFN	IFN	PROPN	NNP	Number=Sing	_	_	_	SpaceAfter=No
32	-	-	PUNCT	HYPH	_	_	_	_	SpaceAfter=No
33	activated	activate	VERB	VBN	Tense=Past|VerbForm=Part	_	_	_	_
34	NK	Nk	PROPN	NNP	Number=Sing	_	_	_	_
35	cells	cell	NOUN	NNS	Number=Plur	_	_	_	SpaceAfter=No
36	.	.	PUNCT	.	_	_	_	_	_

# sent_id = 3886
# text = In conclusion, E1A expression marks cells for destruction by the host NK cell response, whereas the E7 oncoprotein lacks this activity.
1	In	in	ADP	IN	_	_	_	_	_
2	conclusion	conclusion	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
3	,	,	PUNCT	,	_	_	_	_	_
4	E1	E1	NUM	CD	NumType=Card	_	_	_	SpaceAfter=No
5	A	a	DET	DT	Definite=Ind|PronType=Art	_	_	_	_
6	expression	expression	NOUN	NN	Number=Sing	_	_	_	_
7	marks	mark	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
8	cells	cell	NOUN	NNS	Number=Plur	_	_	_	_
9	for	for	ADP	IN	_	_	_	_	_
10	destruction	destruction	NOUN	NN	Number=Sing	_	_	_	_
11	by	by	ADP	IN	_	_	_	_	_
12	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
13	host	host	NOUN	NN	Number=Sing	_	_	_	_
14	NK	NK	PROPN	NNP	Number=Sing	_	_	_	_
15	cell	cell	PROPN	NNP	Number=Sing	_	_	_	_
16	response	response	NOUN	NN	Number=Sing	_	_	_	SpaceAfter=No
17	,	,	PUNCT	,	_	_	_	_	_
18	whereas	whereas	SCONJ	IN	_	_	_	_	_
19	the	the	DET	DT	Definite=Def|PronType=Art	_	_	_	_
20	E7	E7	NOUN	NN	Number=Sing	_	_	_	_
21	oncoprotein	oncoprotein	ADV	WRB	PronType=Rel	_	_	_	_
22	lacks	lack	VERB	VBZ	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	_	_	_	_
23	this	this	DET